US Patent No. 10,364,295

RECOMBINANT MONOCLONAL ANTIBODIES AND CORRESPONDING ANTIGENS FOR COLON AND PANCREATIC CANCERS


Patent No. 10,364,295
Issue Date July 30, 2019
Title Recombinant Monoclonal Antibodies And Corresponding Antigens For Colon And Pancreatic Cancers
Inventorship Myron Arlen, Great Neck, NY (US)
J. Andrew Bristol, Rockville, MD (US)
Ariel Hollinshead, Rockville, MD (US)
Kwong Tsang, Bethesda, MD (US)
Assignee PRECISION BIOLOGICS, INC., Rockville, MD (US)

Claim of US Patent No. 10,364,295

1. An isolated nucleic acid encoding at least one of the light or heavy chain of an a monoclonal antibody or antigen-binding fragment thereof that binds to the human colorectal and pancreatic carcinoma-associated antigen (CPAA) expressed by LS174T colorectal cancer cells and bound by the NPC-1 antibody consisting of the light chain variable region of SEQ ID NO: 1 and the heavy chain variable region of SEQ ID NO: 4, wherein said monoclonal antibody or antigen-binding fragment thereof comprises the light chain CDR1 amino acid sequence of SEQ ID NO:7, light chain CDR2 amino acid sequence of SEQ ID NO:8, and light chain CDR3 amino acid sequence of SEQ ID NO:9, and wherein said monoclonal antibody or antigen-binding region thereof comprises the heavy chain CDR1 amino acid sequence of SEQ ID NO:10, heavy chain CDR2 amino acid sequence of SEQ ID NO:11, and heavy chain CDR3 amino acid sequence of SEQ ID NO:12.