US Patent No. 10,363,559

APPARATUS FOR THE SEPARATION OF PLASMA


Patent No. 10,363,559
Issue Date July 30, 2019
Title Apparatus For The Separation Of Plasma
Inventorship Gert Blankenstein, Dortmund (DE)
Holger Bartos, Dortmund (DE)
Ralf-Peter Peters, Bergisch-Gladbach (DE)
Christian Schoen, Dresden (DE)
Assignee Boehringer Ingelheim International GmbH, Ingelheim am Rhein (DE)

Claim of US Patent No. 10,363,559

1. An apparatus (1) for absorbing blood (19) and separating blood components as a sample liquid (2), comprising:a carrier (6) defining a base of the apparatus and having a lower boundary surface,
a feed device (13) spaced away from the lower boundary surface of the carrier (6) in a direction opposite to an input direction for receiving the blood (19) into the feed device (13),
a separating device (15) for separating the blood components as the sample liquid (2), the separating device (15) being spaced away from the carrier (6) in the direction opposite to the input direction, the separating device (15) including a first surface facing the blood (19) as the blood (19) is received into the feed device (13) and a second surface opposite to the first surface and facing towards the lower boundary surface, where a volume is defined between the second surface of the separating device (15) and the lower boundary surface of the carrier (6),
a channel (3), in fluid communication with the volume, which takes up the sample liquid (2) exclusively by capillary forces,
a filling device for filling the channel (3) with the sample liquid (2) in an inlet or feed region (18) of the channel (3), and
an insert (35) disposed in the volume between the second surface of the separating device (15) and the lower boundary surface of the carrier (6), where the insert (35): (i) is at least partially annular about an axis defined by the input direction, (ii) includes respective inner and outer cylindrical surfaces about the axis, and (iii) includes longitudinally disposed notches running on at least one of the inner and outer surfaces of the cylinder in directions parallel to the input direction of introducing the blood.