US Patent No. 10,363,272

RAR SELECTIVE AGONISTS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER IMMUNOTHERAPY


Patent No. 10,363,272
Issue Date July 30, 2019
Title Rar Selective Agonists In Combination With Immune Modulators For Cancer Immunotherapy
Inventorship Roshantha A. Chandraratna, San Juan Capistrano, CA (US)
Martin E. Sanders, Seattle, WA (US)
Assignee Io Therapeutics, Inc., Almeda, TX (US)

Claim of US Patent No. 10,363,272

1. A method of potentiating chimeric antigen receptor-modified immune cells (CAR-MIC) cancer immunotherapy comprising administering at least one differentiating retinoic acid receptor (RAR) active agent, wherein the differentiating RAR active agent is a RAR? agonist, to a cancer patient who is receiving, has received, or is scheduled to receive, CAR-MIC, wherein the RAR? agonist is a CYP26 metabolism-resistant, RAR? selective agonist having a structure of general formula (I)
wherein R1 is H or C1-6 alky, R2 and R3 are independently H or F, and R4 is a halogen.