US Patent No. 10,363,041

IMPLANTABLE NERVE GUIDANCE CONDUITS HAVING POLYMER FIBER GUIDANCE CHANNEL


Patent No. 10,363,041
Issue Date July 30, 2019
Title Implantable Nerve Guidance Conduits Having Polymer Fiber Guidance Channel
Inventorship Xiaojun Yu, Fishers, IN (US)
Munish B. Shah, Galloway, NJ (US)
Wei Chang, New York, NY (US)
Assignee THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY, Hoboken, NJ (US)

Claim of US Patent No. 10,363,041

1. A nerve guidance conduit for promoting regeneration of a severed nerve, comprising:a fibrous tube, said fibrous tube defining a lumen within said fibrous tube, and said fibrous tube having a longitudinal axis, an inner surface, an outer surface, a first end, a second end opposite said first end along said longitudinal axis, and a first length from said first end of said fibrous tube to said second end of said fibrous tube;
a plurality of individual tubular members of a spiral cross-sectional shape positioned entirely within said lumen of said fibrous tube, each tubular member of said plurality of tubular members being porous and having a respective outer wall, a respective inner wall, a respective internal guidance channel defined by said respective inner wall, a respective longitudinal axis in substantially parallel alignment with said longitudinal axis of said fibrous tube, a respective first end, a respective second end opposite said respective first end along said respective longitudinal axis, and a respective second length from said respective first end to said respective second end, said respective second length being less than said first length of said fibrous tube, a first one of said plurality of tubular members bordering a first portion of said inner surface of said fibrous tube and a second one of said plurality of tubular members bordering a second portion of said inner surface of said fibrous tube in close proximity to said first tubular member such that said first and second tubular members cooperate with each other and with said inner surface of said fibrous tube to define at least one peripheral guidance channel external of said first and second tubular members but internal of said fibrous tube;
a first plurality of nanofibers randomly distributed on said outer surface of said fibrous tube;
a second plurality of nanofibers arranged on said inner surface of said fibrous tube substantially parallel to said longitudinal axis of said fibrous tube;
a third plurality of nanofibers arranged on said respective inner wall of at least one of said plurality of tubular members substantially parallel to said longitudinal axis of said fibrous tube; and
a fourth plurality of nanofibers arranged on said respective outer wall of at least one of said plurality of tubular members substantially parallel to said longitudinal axis of said fibrous tube, wherein at least some of said fourth plurality of nanofibers are situated in said at least one peripheral guidance channel.