US Patent No. 10,362,950

NON-INVASIVE METHOD AND SYSTEM FOR MEASURING MYOCARDIAL ISCHEMIA, STENOSIS IDENTIFICATION, LOCALIZATION AND FRACTIONAL FLOW RESERVE ESTIMATION


Patent No. 10,362,950
Issue Date July 30, 2019
Title Non-invasive Method And System For Measuring Myocardial Ischemia, Stenosis Identification, Localization And Fractional Flow Reserve Estimation
Inventorship Sunny Gupta, Amherstview (CA)
Shyamlal Ramchandani, Kingston (CA)
Timothy Burton, Ottawa (CA)
William Sanders, Bethesda, MD (US)
Ian Shadforth, Morrisville, NC (US)
Assignee Analytics For Life Inc., Toronto (CA)

Claim of US Patent No. 10,362,950

1. A method for non-invasively identifying and/or measuring or estimating a degree of myocardial ischemia, identifying one or more stenoses, and/or localizing and/or estimating fractional flow reserve, the method comprising:obtaining, by one or more processors, a data set associated with a plurality of wide-band gradient signals simultaneously from the subject via at least one electrode;
generating, by the one or more processors, a residue subspace data set and a noise subspace data set from the data set associated with the plurality of wide-band gradient signals;
determining, via the one or more processors, one or more coronary physiological parameters of the subject selected from the group consisting of a fractional flow reserve estimation, a stenosis value, and a myocardial ischemia estimation, based on the residue subspace data set and the noise subspace data set; and
output, via one or more of an output data set in a report and/or a display, the one or more coronary physiological parameters, wherein the output is used in the diagnosis of cardiac disease.