US Patent No. 10,228,378

DIAGNOSTIC AND THERAPEUTIC METHODS AND PRODUCTS RELATED TO ANXIETY DISORDERS


Patent No. 10,228,378
Issue Date March 12, 2019
Title Diagnostic And Therapeutic Methods And Products Related To Anxiety Disorders
Inventorship Victor May, Essex, VT (US)
Kerry J. Ressler, Atlanta, GA (US)
Sayamwong E. Hammack, Essex Junction, VT (US)
Donna Toufexis, So. Burlington, VT (US)
Karen M. Braas, Essex, VT (US)
Assignee The University of Vermont and State Agricultural College, Burlington, VT (...

Claim of US Patent No. 10,228,378

1. A method for diagnosing an anxiety disorder in a subject, comprising:a. collecting a DNA sample from the subject;
b. analyzing the DNA sample for the presence of a SNP in a PAC1 receptor gene and/or for epigenetic methylation at a first site within a ADCYAP1R1 CpG island;
c. diagnosing the anxiety disorder in the subject having the SNP in the PAC1 receptor gene and/or having elevated levels of epigenetic methylation; and
d. administering a therapeutically effective amount of a PACAP inhibitor or PACAP receptor antagonist.