US Patent No. 10,189,961

CREEP RESISTANT, HIGHLY LUBRICIOUS, TOUGH, AND IONIC HYDROGELS INCLUDING PVA-PAAMPS HYDROGELS


Patent No. 10,189,961
Issue Date January 29, 2019
Title Creep Resistant, Highly Lubricious, Tough, And Ionic Hydrogels Including Pva-paamps Hydrogels
Inventorship Orhun K. Muratoglu, Cambridge, MA (US)
Hatice Bodugoz-Senturk, Boston, MA (US)
Assignee The General Hospital Corporation, Boston, MA (US)

Claim of US Patent No. 10,189,961

1. A method of making a creep resistant, highly lubricious, tough and ionic hydrogel comprising:a) mixing an aqueous solution of a polymer with an aqueous solution of an ionic monomeric compound in presence of an initiator, thereby forming an ionic hydrogel solution, wherein the aqueous solution of the polymer comprises 1% w/w to 25% w/w of the polymer, and wherein the aqueous solution of the ionic monomeric compound comprises 5% w/w to 25% w/w of the ionic monomeric compound;
b) heating and/or irradiating the ionic hydrogel solution, thereby forming an inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution; and
c) subjecting the inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution to one or more freeze-thaw cycles to physically-crosslink the polymer, thereby forming a creep resistant, highly lubricious, tough and ionic hydrogel, and
d) annealing the ionic hydrogel,
wherein the polymer is poly(vinyl alcohol) (PVA), and the ionic monomeric compound is a acrylamido-methylpropane sulfonic acid (AAMPS) solution, and the inter-penetrating network (IPN) structure of polymerized ionic hydrogel is an inter-penetrating network (IPN) structure of polymerized PAAMPS, and the creep resistant, highly lubricious, tough and ionic hydrogel is a creep resistant, highly lubricious, tough and ionic PVA-PAAMPS-hydrogel.