US Patent No. 10,189,896

ANTIBODY TO GDF8 AND USES THEREOF


Patent No. 10,189,896
Issue Date January 29, 2019
Title Antibody To Gdf8 And Uses Thereof
Inventorship Edward Roland LaVallie, Harvard, MA (US)
Lisa Anne Collins-Racie, Acton, MA (US)
Christopher John Corcoran, Arlington, MA (US)
Lioudmila Gennadievna Tchistiakova, Andover, MA (US)
John Adam Nowak, Stratham, NH (US)
Riyez Karim, North Andover, MA (US)
Xiang-Yang Tan, Reading, MA (US)
Kimberly Ann Marquette, Somerville, MA (US)
Geertruida Machteld Veldman, Sudbury, MA (US)
Assignee PFIZER INC., New York, NY (US)

Claim of US Patent No. 10,189,896

1. A method of detecting GDF-8 in a sample, comprising contacting a sample suspected of containing GDF-8 with a capture reagent and detecting GDF-8 in said sample, wherein the capture reagent is an antibody or antigen-binding fragment thereof that specifically binds GDF-8 comprising an antibody variable heavy (VH) region comprising the first, second and third complementarity determining regions (CDRs) from the VH region defined by the amino acid sequence of SEQ ID NO:14 or SEQ ID NO:17, and an antibody variable light (VL) region comprising the first, second and third CDRs from the VL region defined by the amino acid sequence of SEQ ID NO:16 or SEQ ID NO:18.