US Patent No. 10,188,600

STABLE LIQUID ANTIBODY FORMULATION


Patent No. 10,188,600
Issue Date January 29, 2019
Title Stable Liquid Antibody Formulation
Inventorship Advait Vijay Badkar, Chesterfield, MO (US)
Leigh Kristen Bohack, Chesterfield, MO (US)
Kevin Roger King, Chesterfield, MO (US)
Alanta Lea Lary, Chesterfield, MO (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 10,188,600

1. A liquid composition comprising;about 2.5 mg/ml to about 20 mg/ml of an anti-NGF antibody,
about 80 mg/ml to 85 mg/ml trehalose dihydrate,
about 9.0 mM to 10.0 mM histidine buffer,
about 0.05 mg/ml to 0.1 mg/ml disodium EDTA, and
about 0.01 mg/ml to 0.15 mg/ml polysorbate 20 (PS20),
wherein the pH of said composition is from 5.8 to 6.8, wherein the antibody comprises a heavy chain variable region amino acid sequence shown in SEQ ID NO: 1, and a light chain variable region amino acid sequence shown in SEQ ID NO: 2.