US Patent No. 10,188,600
STABLE LIQUID ANTIBODY FORMULATION
| Patent No. | 10,188,600 |
|---|---|
| Issue Date | January 29, 2019 |
| Title | Stable Liquid Antibody Formulation |
| Inventorship | Advait Vijay Badkar, Chesterfield, MO (US) Leigh Kristen Bohack, Chesterfield, MO (US) Kevin Roger King, Chesterfield, MO (US) Alanta Lea Lary, Chesterfield, MO (US) |
| Assignee | Pfizer Inc., New York, NY (US) |
Claim of US Patent No. 10,188,600
1. A liquid composition comprising;about 2.5 mg/ml to about 20 mg/ml of an anti-NGF antibody,
about 80 mg/ml to 85 mg/ml trehalose dihydrate,
about 9.0 mM to 10.0 mM histidine buffer,
about 0.05 mg/ml to 0.1 mg/ml disodium EDTA, and
about 0.01 mg/ml to 0.15 mg/ml polysorbate 20 (PS20),
wherein the pH of said composition is from 5.8 to 6.8, wherein the antibody comprises a heavy chain variable region amino acid sequence shown in SEQ ID NO: 1, and a light chain variable region amino acid sequence shown in SEQ ID NO: 2.
about 80 mg/ml to 85 mg/ml trehalose dihydrate,
about 9.0 mM to 10.0 mM histidine buffer,
about 0.05 mg/ml to 0.1 mg/ml disodium EDTA, and
about 0.01 mg/ml to 0.15 mg/ml polysorbate 20 (PS20),
wherein the pH of said composition is from 5.8 to 6.8, wherein the antibody comprises a heavy chain variable region amino acid sequence shown in SEQ ID NO: 1, and a light chain variable region amino acid sequence shown in SEQ ID NO: 2.