US Patent No. 10,175,237

METHODS AND COMPOUNDS FOR DIAGNOSING THREONYL-TRNA SYNTHETASE-ASSOCIATED DISEASES AND CONDITIONS


Patent No. 10,175,237
Issue Date January 08, 2019
Title Methods And Compounds For Diagnosing Threonyl-trna Synthetase-associated Diseases And Conditions
Inventorship Christopher Francklyn, Burlington, VT (US)
Karen M. Lounsbury, Essex Junction, VT (US)
Tamara Williams, South Burlington, VT (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US)

Claim of US Patent No. 10,175,237

1. A method for determining a prognosis in a subject diagnosed with a disorder associated with increased threonyl-tRNA synthetase (TARS) activity, the method comprising:(a) obtaining a biological sample from the subject;
(b) measuring a TARS molecule level in the subject's biological sample;
(c) comparing the TARS molecule level of the subject's sample with a control level of the TARS molecule;
(d) correlating levels of the TARS molecule at least 25% greater than the control level with an indication of unfavorable prognosis and levels of the TARS molecule at or below the control level with a favorable prognosis; and
(e) administering to the subject with an indication of unfavorable prognosis a treatment selected from the group consisting of one or more of a medicament, surgery, radiation and chemotherapy
(f) wherein, the disorder is selected from prostate cancer and ovarian cancer.