US Patent No. 10,172,930

VIRUS LIKE PARTICLE PURIFICATION


Patent No. 10,172,930
Issue Date January 08, 2019
Title Virus Like Particle Purification
Inventorship Thomas S. Vedvick, Cambridge, MA (US)
Bryan Steadman, Cambridge, MA (US)
Charles Richardson, Cambridge, MA (US)
Thomas R. Foubert, Cambridge, MA (US)
Charles R. Petrie, Cambridge, MA (US)
Assignee TAKEDA VACCINES, INC., Cambridge, MA (US)

Claim of US Patent No. 10,172,930

1. A composition comprising Norovirus genogroup II, genotype 4 (GII.4) virus-like particles (VLPs), wherein the composition is prepared by a method comprising contacting a solution containing said VLPs with at least one chromatographic material, wherein the at least one chromatographic material is an anion exchange chromatographic material, wherein the chromatographic materials used in the method do not comprise hydroxyapatite, and wherein the VLPs are present in the composition at a purity level of greater than about 90%.