US Patent No. 10,125,358

METHODS AND COMPOUNDS FOR INCREASING THREONYL-TRNA SYNTHETASE ACTIVITY


Patent No. 10,125,358
Issue Date November 13, 2018
Title Methods And Compounds For Increasing Threonyl-trna Synthetase Activity
Inventorship Christopher Francklyn, Burlington, VT (US)
Karen M. Lounsbury, Essex Junction, VT (US)
Jason Botten, Williston, VT (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US)

Claim of US Patent No. 10,125,358

1. A method of increasing angiogenesis in at least one cell, the method comprising, contacting a plurality of cells with a pharmaceutical composition comprising an effective amount of a TARS-activity-enhancing compound to increase angiogenesis at least one cell of the plurality of cells, wherein the TARS-activity-enhancing compound comprises:(a) a threonyl-tRNA synthetase (TARS) nucleic acid molecule having the sequence of: (i) SEQ ID NO: 1, (ii) a modified SEQ ID NO: 1 that has at least 99% sequence identity to SEQ ID NO: 1, wherein each of (i) and (ii) encodes a TARS-activity-enhancing polypeptide; or
(b) a TARS polypeptide having the sequence of (iv) SEQ ID NO: 2, (v) a modified SEQ ID NO: 2 that has at least 99% sequence identity to SEQ ID NO: 2, wherein each of (iv) and (v), is a TARS activity enhancing polypeptide.