US Patent No. 10,113,169

METHODS AND COMPOSITIONS FOR TREATING CANCER USING PEPTIDE NUCLEIC ACID-BASED AGENTS


Patent No. 10,113,169
Issue Date October 30, 2018
Title Methods And Compositions For Treating Cancer Using Peptide Nucleic Acid-based Agents
Inventorship Jeffrey H. Rothman, Greenwich, CT (US)
Gary K. Schwartz, Briarcliff Manor, NY (US)
Assignee Memorial Sloan-Kettering Cancer Center, New York, NY (US)

Claim of US Patent No. 10,113,169

1. A PNA agent comprising:a PNA moiety; and
a first cationic and hydrophobic peptide at the N-terminus of the PNA moiety, wherein the first peptide comprises lysine residues, and at least one of the lysine residues comprises a palmitoyl side chain moiety; and
a second cationic and hydrophobic peptide at the C-terminus of the PNA moiety, wherein the second peptide comprises lysine residues, and at least one of the lysine residues comprises a palmitoyl side chain moiety.