US Patent No. 10,087,435

METHODS AND COMPOUNDS FOR REDUCING THREONYL-TRNA SYNTHETASE ACTIVITY


Patent No. 10,087,435
Issue Date October 02, 2018
Title Methods And Compounds For Reducing Threonyl-trna Synthetase Activity
Inventorship Christopher Francklyn, Burlington, VT (US)
Karen M. Lounsbury, Essex Junction, VT (US)
Jason Botten, Williston, VT (US)
Assignee University of Vermont and State Agricultural College, Burlington, VT (US)

Claim of US Patent No. 10,087,435

1. A composition comprising a fusion protein that comprises a threonyl-tRNA synthetase (TARS)-activity-inhibiting polypeptide fragment with TARS inhibiting activity wherein the amino acid sequence of the TARS polypeptide fragment is: (1) a TARS N1 domain sequence consisting of amino acids 82-143 of SEQ ID NO: 2, (2) a modified sequence of (1) with at least 98% identity to the amino acid sequence of the TARS N1 domain sequence and capable of binding a Von Hippel Lindau factor (VHL) polypeptide; or (3) the polypeptide set forth as SEQ ID NO: 7.