US Patent No. 10,071,992

DIACYLGLYCEROL ACYL TRANSFERASE 2 INHIBITORS


Patent No. 10,071,992
Issue Date September 11, 2018
Title Diacylglycerol Acyl Transferase 2 Inhibitors
Inventorship Markus Boehm, Mansfield, MA (US)
Shawn Cabral, Groton, CT (US)
Matthew S. Dowling, Old Lyme, CT (US)
Kentaro Futatsugi, Quincy, MA (US)
Kim Huard, Medford, MA (US)
Esther Cheng Yin Lee, Brookline, MA (US)
Allyn T. Londregan, Barrington, RI (US)
Jana Polivkova, Mystic, CT (US)
David A. Price, Concord, MA (US)
Qifang Li, Stonington, CT (US)
Assignee Pfizer Inc., New York, NY (US)

Claim of US Patent No. 10,071,992

1. A compound of Formula (I)whereinD1 and D2 are each independently N or CH;
R1 is H, or (C1-C2)alkyl optionally substituted with one or two substituents each independently selected from fluoro and (C3-C6)cycloalkyl;
R2 is H or fluoro;
R3 is,

R4 is H, cyano, or (C1-C4)alkyl optionally substituted with one or two substituents each independently selected from OH and —S(O)2R6;
R5 is H or —OH; and
R6 is (C1-C4)alkyl; or a pharmaceutically acceptable salt thereof.