US Patent No. 10,047,063

METHOD FOR IMPROVING THE OXYGEN-RELEASING ABILITY OF HEMOGLOBIN TO ORGANS OR PERIPHERAL TISSUES IN HUMAN BODIES AND A MEDICATION THEREOF


Patent No. 10,047,063
Issue Date August 14, 2018
Title Method For Improving The Oxygen-releasing Ability Of Hemoglobin To Organs Or Peripheral Tissues In Human Bodies And A Medication Thereof
Inventorship Chia-Chen Wang, Kaohsiung (TW)
Muhammad Zulfajri, Kaohsiung (TW)
You-Qing Yu, Kaohsiung (TW)
Assignee NATIONAL SUN YAT-SEN UNIVERSITY, Kaohsiung (TW)

Claim of US Patent No. 10,047,063

1. A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes to organs or peripheral tissues in human bodies, by administering a compound of Formula I to a subject in need thereof, wherein the compound of Formula I forms at least one hydrogen bond with ?Arg141 of hemoglobin, strengthening the ?1/?2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin in the low oxygen affinity “T” state and facilitating the oxygen release to the organs or the peripheral tissues,
wherein R1 is C2-C6 alkyl, C2-C6 alkenyl or C2-C6 alkenol group;
R2 is one or more H or OH; and
R3 and R4 are each independent H or OH or both of them combine together to form a epoxy group.