US Patent No. 10,016,362

APIXABAN LIQUID FORMULATIONS


Patent No. 10,016,362
Issue Date July 10, 2018
Title Apixaban Liquid Formulations
Inventorship Sherif Ibrahim Farag Badawy, Dayton, NJ (US)
Susan Lum, Toronto (CA)
Assignee BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US) PFIZER INC., New York, N...

Claim of US Patent No. 10,016,362

1. A liquid formulation comprising apixaban and a vehicle,wherein:
water content of the vehicle is about 20% to about 30% w/w of the vehicle;
non-ionic surfactant content of the vehicle is about 11% to about 14% w/w of the vehicle;
hydrophilic polymer content of the vehicle is about 1% to about 7% w/w of the vehicle;
polyhydric alcohol content of the vehicle is about 31% to about 54% w/w of the vehicle;
polyethylene glycol content of the vehicle is about 4% to about 6% w/w of the vehicle;
carbohydrate content of the vehicle is 0% to about 25% w/w of the vehicle,
wherein the vehicle comprises at least one ionic surfactant such that ionic surfactant content of the vehicle is up to about 2% w/w of the vehicle, and
wherein a solubility of apixaban in the vehicle is at least 0.50 mg/mL.