US Patent No. 10,010,600

COMPOSITIONS AND METHODS FOR ADMINISTRATION OF VACCINES AGAINST DENGUE VIRUS


Patent No. 10,010,600
Issue Date July 03, 2018
Title Compositions And Methods For Administration Of Vaccines Against Dengue Virus
Inventorship Dan T. Stinchcomb, Fort Collins, CO (US)
Jorge E. Osorio, Mount Horeb, WI (US)
Charalambos D. Partidos, Chicago, IL (US)
Joseph N. Brewoo, Madison, WI (US)
Assignee TAKEDA VACCINES, INC., Cambridge, MD (US)

Claim of US Patent No. 10,010,600

1. A method for inducing an immune response in a subject against all four dengue virus serotypes, comprising,administering to the subject by at least a first introduction, an immunogenic composition of a mixture comprising components of all four dengue virus serotypes, the composition comprising at least one live, attenuated dengue chimera comprising dengue-2/1, dengue-2/3 and dengue-2/4; and at least a non-chimera live, attenuated dengue-2 virus, and administering at least a second introduction of the immunogenic composition within 30 days of but not on the same day as, the first introduction to the subject and inducing an immune response in the subject against all four dengue virus serotypes.