US Patent No. 10,010,599

NOROVIRUS VACCINE FORMULATIONS


Patent No. 10,010,599
Issue Date July 03, 2018
Title Norovirus Vaccine Formulations
Inventorship Charles Richardson, Bozeman, MT (US)
Thomas S. Vedvick, Federal Way, WA (US)
Thomas R. Foubert, Bozeman, MT (US)
William T. Tino, Belgrade, MT (US)
Assignee TAKEDA VACCINES, INC., Cambridge, MA (US)

Claim of US Patent No. 10,010,599

1. A method of generating an immune response to at least two Norovirus strains by administering to a patient an antigenic formulation comprising a combination of two or more monovalent Norovirus VLPs of different Norovirus genotypes, or an antigenic formulation comprising multivalent VLPs containing capsid proteins from two or more different Norovirus genotypes, wherein at least one of the two or more Norovirus genotypes is a genogroup I genotype I.1 and at least one of the two or more Norovirus genotypes is a genogroup II genotype II.4, such that the combination of VLPs within the formulation does not block the immunogenicity of each VLP type, and wherein immunity is generated against at least one Norovirus strain having a genotype that is different than the genotypes of said VLPs in said formulation.