US Pat. No. 10,363,029

NEEDLE FOR DELIVERY OF DERMAL FILLER THREADS

Allergan Holdings France ...

1. A needle for delivering a dermal filler, the needle comprising:a dermal filler thread;
a tubular body having a proximal portion, a distal portion, and a longitudinal axis;
a coupler in the proximal portion for attaching the dermal filler thread to the needle, the coupler comprising a plurality of segments extending along a longitudinal axis of the coupler, a plurality of slits aligned relative to one another and extending along the longitudinal axis of the coupler between the plurality of segments, a plurality of struts spaced apart and staggered along the longitudinal axis of the coupler, wherein each of the struts is connected to a pairing of the plurality of segments and extends across a slit of the plurality of slits; and
a trocar in the distal portion of the tubular body;
wherein the coupler in the proximal portion is attached to the dermal filler thread.

US Pat. No. 10,363,028

METHOD FOR COUPLING SOFT TISSUE TO A BONE

Biomet Sports Medicine, L...

1. A method for forming a flexible member for coupling tissue, the method comprising:forming a first loop of a self-locking construct of the flexible member by passing a second end of the construct through a first sleeve defined by the self-locking construct proximate to a first end of the self-locking construct;
forming a second loop of the self-locking construct of the flexible member by passing the second end of the self-locking construct through a second sleeve defined proximate to an end of a flexible tail, thereby coupling the self-locking construct to the tail, and then passing the second end through a third sleeve defined by the self-locking construct proximate to the first loop;
wherein the self-locking construct is configured such that passing the tail through the first loop so that the second loop extends into the first loop and forms a tissue capture region defined by the self-locking construct; and
wherein the flexible tail defines a locking member at the second sleeve that is configured to secure the second loop to the first loop.

US Pat. No. 10,363,027

SUTURE ASSEMBLY INCLUDING A SUTURE ATTACHED TO A LEADER

1. A suture assembly engageable with a needle of a tissue suturing tool, the suture assembly comprising:a leader including a band, a clasp extending from a distal edge of the band, and at least two prongs extending from a proximal edge of the band, where the band is curved to provide the leader with an exterior surface that defines an outermost perimeter of the leader and an interior surface opposite of the exterior surface; and
a suture, with the clasp crimped onto the suture such that the suture is captured within the outermost perimeter of the leader;
wherein each of the at least two prongs is formed to have:
a curved section that forms a proximal-most end of the leader, and
a prong end coupled to the curved section, where the prong end is located closer to band than the curved section that forms the proximal-most end of the leader;
wherein the suture is one of a resorbable tissue suture and a bioabsorbable tissue suture.

US Pat. No. 10,363,024

SYSTEM FOR MENISCAL REPAIR USING SUTURE IMPLANT CINCH CONSTRUCT

Arthrex, Inc., Naples, F...

1. A system for repairing tears in soft tissue, comprising:a first implant;
a second implant;
a flexible strand connecting the first implant and the second implant;
a sliding knot in the flexible strand that is adjustable for reducing a length of the flexible strand that is located between the first implant and the second implant; and
a delivery system for implanting the first implant and the second implant into the soft tissue, wherein the delivery system includes:
a handle;
an elongated shaft connected to the handle;
a trocar assembly movable within the elongated shaft, wherein the first implant and the second implant are carried through the elongated shaft by the trocar assembly; and
a depth stop adjustable between a first position that corresponds to a first insertion distance the trocar assembly extends beyond a tip of the elongated shaft and a second position that corresponds to a second, different insertion distance the trocar assembly extends beyond the tip,
wherein the trocar assembly includes a first trocar that is slidable within a lower slot of a first hole formed in the handle and a second trocar that is removably received within an upper slot of the first hole of the handle,
wherein a first trocar handle of the first trocar abuts the depth stop when the depth stop is in the second position to limit movement of the first trocar beyond the second insertion distance.

US Pat. No. 10,363,023

LATERAL RETRACTOR SYSTEM FOR MINIMIZING MUSCLE DAMAGE IN SPINAL SURGERY

1. A lateral retractor system for forming a surgical pathway to a patient's intervertebral disc space, comprising:a dilator having a narrow body defined by opposing flat surfaces that extend between a proximal end and a distal end, the distal end tapering to a distal edge configured for insertion at an insertion orientation in which the opposing flat surfaces are parallel to a plurality of psoas muscle fibers and angled relative to the intervertebral disc space; and
a retractable dual-blade assembly consisting of two opposing blade subassemblies, each of the blade subassemblies comprising:
a blade having a planar inner surface, an outer surface, a proximal blade portion, a distal blade portion, and opposing longitudinal edges extending from a proximal end of the proximal blade portion to a distal end of the distal blade portion; and
an adjustable wing hingedly coupled with each of the opposing longitudinal edges of the blade, each adjustable wing configured to move between an open position parallel to the planar inner surface of the blade and a closed position perpendicular to the planar inner surface of the blade, the retractable dual-blade assembly configured to pass over the dilator at the insertion orientation such that the planar inner surfaces of the blades contact the opposing flat surfaces of the dilator.

US Pat. No. 10,363,022

SCREW BASED RETRACTOR WITH EXPANDABLE BLADES

SPINE WAVE, INC., Shelto...

1. A screw-based retractor, comprising:an elongate rack having a rack axis;
a plurality of arms slidably supported for translational movement on said rack toward and away from each other, each arm having an arm axis and comprising a proximal portion slidably supported by said rack and a distal portion, each said arm axis extending generally transversely relative to said rack axis, at least one of said arms including at its distal portion a curved track and a blade receptacle slidable within said curved track in a manner to provide articulation of said blade receptacle in a curved path relative to said at least one arm about an articulation point spaced from and not located on said at least one arm;
a plurality of blades, one each supported by a respective arm at the distal portion thereof, said blades projecting generally transversely relative to said rack axis and to said arm axis of said respective arms;
at least one of said blades having a proximal end defining an arm attachment and an opposing distal end defining a screw attachment, and a blade extent extending between said proximal end and said distal end, said arm attachment being releasably attached to said blade receptacle such that said blade articulates with said blade receptacle.

US Pat. No. 10,363,021

VASCULAR CLOSURE DEVICES AND METHODS PROVIDING HEMOSTATIC ENHANCEMENT

Cardiva Medical, Inc., S...

1. A device for closing a blood vessel puncture site disposed at a distal end of a tissue tract, the device comprising:a tubular shaft having a proximal end and a distal end, the tubular shaft being configured to advance through the tissue tract;
a hemostasis promoting agent deposited in hemostasis promoting region disposed on the tubular shaft near its distal end;
an expansible member disposed on the tubular shaft distal to the hemostasis promoting region, said expansible member being deployable within the blood vessel;
a tubular sealing member slidably disposed over the tubular shaft and having a distally advanced position which provides a barrier over the hemostasis promoting region and a proximally retracted position which exposes the hemostasis promoting region, and wherein the tubular sealing member has a proximal end and a distal end; and
a tensioning element disposed coaxially over the tubular shaft, under the tubular sealing member and proximal the expansible member, wherein the tensioning element has a proximal end attached to the proximal end of the tubular sealing member and a distal end attached to the tubular shaft so that proximal retraction of the tubular sealing member relative to the distal end of the tubular shaft both exposes the hemostasis promoting region and applies tension to the tubular shaft in a proximal direction to seat the expansible member against the puncture site.

US Pat. No. 10,363,014

STEERABLE ULTRASOUND ATTACHMENT FOR ENDOSCOPE

ENDOSOUND, LLC, Boca Rat...

1. A method of adding elements to an endoscope, to create an ultrasound capable endoscope, comprising:a. providing an endoscope, having a distal end and an elongate body defining one or more lumens;
b. providing an ultrasound assembly that includes:
i. a multiconductor electrical connector,
ii. a first multiconductor cable, including a multiplicity of coaxial cables, connected to said multiconductor electrical connector, and having a distal end;
iii. an endoscope attachment element, attached to said first multiconductor cable, and sized to attach to said distal end of said endoscope;
iv. a neck, connected and extending in a distal manner from said distal end of said first multiconductor cable, and having a distal end, said neck being resiliently deformable;
v. a second multiconductor cable, having a proximal end connected to said distal end of said first multiconductor cable, and having a distal end;
vi. an ultrasound transducer head, including a protective covering, supported by said distal end of said neck, and an ultrasound transducer, inside said protective covering and electrically connected to said distal end of said second multiconductor cable; and
vii. a tension member, connected to said ultrasound transducer head, and extending to said proximal end of said endoscope;
c. attaching said endoscope attachment element to said distal end of said endoscope and arranging said tension member so that it extends from a proximal point of said endoscope to said transducer head;
d. whereby said ultrasound transducer head can be introduced into a patient body cavity, with said endoscope, and may be angle adjusted by said tension member by pulling on said tension member to bend said neck thereby adjusting position of said ultrasound transducer head, and may communicate with an imaging station by means of said first and second multiconductor cables, thereby permitting a user to more accurately aim the imaging head at a feature of interest; and
e. further wherein said neck defines an aperture, permitting a needle to be extended from a lumen of said endoscope, through said aperture, to perform a medical procedure, when said neck is flexed by said tension member.

US Pat. No. 10,363,011

AUTOMATIC DOSE CONTROL FOR IMAGING MEDICAL DEVICES

Siemens Healthcare GmbH, ...

1. A method for automatically calculating at least one target acquisition parameter to control a radiation dose of ionizing radiation of a region to be irradiated by an imaging device, the method comprising:acquiring patient-specific parameters, device-specific parameters, or both the patient-specific parameters and the device-specific parameters;
determining at least one anatomical target region in which the ionizing radiation is to be applied;
accessing a data store via a network, wherein a dose-protocol index for a plurality of images is stored in the data store together with associated radiation dose data for selecting at least one reference image that relates to the at least one anatomical target region or completely encompasses the at least one anatomical target region; and
automatically evaluating the at least one reference image selected with respect to the image quality and the radiation dose used, taking into account the acquired patient-specific and/or the device-specific parameters for calculating the at least one target acquisition parameter, wherein the evaluating of the image quality includes a delimitation algorithm in order to automatically analyze how adequately a respective anatomical structure is configured to be delimited from surrounding structures in the reference image.

US Pat. No. 10,363,009

METHOD AND APPARATUS FOR CORRECTION OF A SYNTHETIC ELECTRON DENSITY MAP

Siemens Healthcare GmbH, ...

1. A method for determining a corrected synthetic electron density map, the method comprising:acquiring, using a magnetic resonance (MR) device, at least one magnetic resonance image dataset taken of a patient;
determining, by a processor, a first synthetic electron density map of the patient based on the at least one magnetic resonance image dataset taken of the patient;
determining, by the processor, at least one first soft tissue image structure of the patient, at least one first bone image structure of the patient, or at least one first soft tissue image structure and at least one first bone image structure of the patient based on the first synthetic electron density map;
comparing, by the processor, the first soft tissue image structure, the first bone image structure, or the first soft tissue image structure and the first bone image structure from the first synthetic electron density map with corresponding image structures in the [ [MR]] at least one magnetic resonance image dataset taken of the patient;
determining, by the processor, a corrected synthetic electron density map, the determining of the corrected synthetic electron density map comprising correcting the first soft tissue image structure, the first bone image structure, or the first soft tissue image structure and the first bone image structure, based on the comparison; and
creating, by the processor, a plan for a radiation based treatment of a target volume of the patient based on the corrected synthetic electron density map.

US Pat. No. 10,363,008

COMPUTED TOMOGRAPHY PERFUSION (CTP) METHOD AND APPARATUS USING BLOOD FLOW FOR DISCRIMINATING TYPES OF CANCER

Canon Medical Systems USA...

1. A method of using computed tomography perfusion to determine a treatment of a pulmonary lesion, the method comprising:obtaining a computed tomography perfusion (CTP) image representing blood flow in a region of a lung that includes the pulmonary lesion;
identifying, using the CTP image, a region of interest (ROI) of the pulmonary lesion,
determining, using the ROI and the CTP image, CTP values representing perfusion in the ROI of the lesion; and
classifying the pulmonary lesion according to whether the pulmonary lesion has a genetic mutation based on the CTP values and using one or more predefined thresholds corresponding respectively to one or more of the CTP values.

US Pat. No. 10,363,006

MOBILE IMAGING SYSTEM AND METHOD

1. An alignment control system, comprising:an alignment computer comprising a central processing unit and software, the software when executed by the central processing unit cause the central processing unit to:
receive a first set of alignment data from a plurality of sensors associated to a radiation source;
receive a second set of alignment data from a plurality of sensors associated to a portable detector;
if an alignment condition between the first set of alignment data and the second set of alignment data has achieved one or more predetermined alignment conditions, send an activation signal to the radiation source to indicate that radiation may be emitted;
continuously monitor alignment conditions to prevent emission of radiation, by the radiation source, if the first set of alignment data and the second set of alignment data have not achieved the one or more alignment conditions.

US Pat. No. 10,363,001

MAGNETIC RESONANCE IMAGING APPARATUS

SAMSUNG ELECTRONICS CO., ...

1. A magnetic resonance imaging apparatus comprising:a table disposed in a cavity which is formed in a bore;
a head support having a support hole where a face of an object disposed on the table is positioned;
an abdomen support having a slope to support an abdomen of the object;
a display configured to display a graphical user interface (GUI) image, the display being disposed between the table and the head support, the display comprising a projector configured to project the GUI image and a screen on which the GUI image projected by the projector is displayed; and
a guide configured to facilitate a vertical movement of the projector;
wherein an upper surface of the table is visible to the object through the support hole,
wherein the guide has a curved shape to form the GUI image projected by the projector while vertically moving on the screen, and
wherein the screen is configured to vertically move between the head support and the upper surface of the table, in accordance with a changing position of the projector.

US Pat. No. 10,363,000

AUTOMATIC REAL-TIME CHANGES TO THE SIZE OF A PATIENTS DATA DISPLAY

KONINKLIJKE PHILIPS N.V.,...

1. A medical monitoring system comprising:one or more electronic processors configured to:
receive vital signs of each of a plurality of patients; and
dynamically configure in real-time a display of the received vital signs which includes for each patient an individually assigned patient sector display sized from available space for the display based on a priority order; and
one or more display devices which display the configured display of the plurality of patient sector displays;
wherein the priority order is based on a set of rules, the set of rules including the assignment of space to sectors based on specified minimum size, specified data elements, space assigned to all sourced vital signs, a specified maximum sector size, and an absence of sourced vital signs, the set of rules including the assignment of space:
first to sectors with a user-specified minimum size,
second to sectors with one or more user-specified data elements,
third to sectors smaller than a predetermined minimum sector size,
fourth to smaller sectors,
fifth to sectors with space assigned to all sourced vital signs,
sixth to sectors with a user-specified maximum sector size with the maximum size assigned, and
seventh to sectors with no sourced vital signs.

US Pat. No. 10,362,995

OUTDOOR GROUP EXERCISE INFORMATION ADMINISTERING SYSTEM

Bion Inc., New Taipei (T...

1. An outdoor group exercise information administering system comprising a team leader and a plurality of exercising members forming an outdoor exercising group in an outdoor environment, the team leader being configured with a master controller and each of the exercising members being configured with a member controller, wherein each of the member controllers including:a member processor;
at least one outdoor exercising signal sensor connected to the member processor for sensing at least one outdoor exercising signal of the exercising member when the exercising member is doing exercising in the outdoor environment;
an identification preset unit connected to the member processor, preset with an identification code for identifying the exercising member;
a member transceiver connected to the member processor for transmitting the outdoor exercising signal and the identification code;
the master controller including:
a leader processor;
a master transceiver connected to the leader processor and wirelessly communicated with the member transceiver of each member controller, for receiving the outdoor exercising signal and the identification code from the member transceiver of each member controller;
a team exercising data storage connected to the leader processor for storing and organizing the outdoor exercising signal and the identification code transmitted from the member transceiver of each of the member controllers based on the identification code respectively; and
a data transmission interface connected to the leader processor for transmitting the outdoor exercising signal and the identification code received through the master transceiver;
a communication connection device communicated with the data transmission interface of the master controller for transmitting the outdoor exercising signal and the identification code from each exercising member to a remote data collection center;
the exercising member including at least one outdoor location sensor connected to the member processor of the exercising member for sensing at least one outdoor location signal of the exercising member; and
the outdoor location sensor including:
a satellite positioning signal receiver connected to the member processor for receiving a satellite positioning signal corresponding to the location of the exercising member;
a latitude and longitude signal sensor connected to the member processor for receiving at least one latitude and longitude signal of the exercising member; and
an altitude measurement sensor connected to the member processor for detecting at least one altitude signal of the exercising member.

US Pat. No. 10,362,992

SYSTEM AND METHOD FOR DETECTION OF MOTION IN DYNAMIC MEDICAL IMAGES

General Electric Company,...

1. A method for automated detection of motion, the method comprising:identifying a region of interest in each of a plurality of images corresponding to a subject of interest;
determining signal characteristics corresponding to the region of interest in each of the plurality of images;
generating a cumulative aggregate signal which includes an aggregate of the signal characteristics corresponding to the region of interest in each of the plurality of images; and
analyzing the cumulative aggregate signal to detect motion in the region of interest.

US Pat. No. 10,362,987

APPARATUSES AND METHODS FOR MONITORING MEDICATION-TAKING STATUS

Ziqiang Hong, Irving, TX...

1. An apparatus for monitoring a medication-taking status, configured as a part of orcoupled with a medication container, comprising:
a first sensor that is disposed inside the apparatus, activated upon a detection by a second sensor of a motion of the medication container, or a non-motion of the medication container for a predefined time period, and configured to measure medication pills stored in the medication container;
a control module configured
to determine the medication-taking status based on the measurement of the medication pills; and
a communication module that is disposed inside the apparatus and configured to transmit at least one of a report and a warning message based at least in part on the medication-taking status to at least one remote subscriber,
wherein the first sensor is deactivated after a predetermined period of inactivity and the apparatus is activated when an activation button is pressed, the activation button being disposed on an outer surface of the apparatus; and wherein the second sensor comprises a gyro sensor configured to detect the motion or non-motion of the medication container, the gyro sensor being disposed inside the apparatus.

US Pat. No. 10,362,986

SLEEP MONITORING SYSTEM

University College Dublin...

1. A sleep monitoring method performed by a system comprising a sensor interface and one or more processors, the method comprising the steps of:receiving, at the sensor interface, signals from a first sensor monitoring a cardiac activity of a patient;
deriving, by the one or more processors, heart beat interval data from the signals received from the first sensor;
extracting, by the one or more processors, one or more first time domain features and one or more first frequency domain features from the heart beat interval data;
deriving, by the one or more processors, amplitude modulation data, caused by respiratory motion, from the signals received from the first sensor;
extracting, by the one or more processors, one or more second time domain features and one or more second frequency domain features from the amplitude modulation data;
combining, by the one or more processors operating as a classifier, one or more of the first extracted time domain features, one or more of the first extracted frequency domain features, one or more of the second extracted time domain features, and one or more of the second extracted frequency domain features;
determining, by the one or more processors operating as the classifier, a plurality of sleep or wake stages of the patient based on the combined features, wherein the plurality of sleep or wake stages include one or more of (a) Wake stages, (b) Rapid Eye Movement (REM) Sleep stages, and (c) Non-REM Sleep stages; and
generating, by the one or more processors, a plot indicating periods of the determined plurality of sleep or wake stages.

US Pat. No. 10,362,983

NEAR INFRARED PHOTONIC PROSTATOSCOPY ANALYZER

1. An infrared (IR) Photonic Analyzer System comprises an IR Scanning polarization unit for generating an illumination beam and receiving an image beam;an elongate generally cylindrical optical probe dimensioned and configured for insertion into a rectum, said optical probe defining an optical path and having a transparent optical window for transmitting an illumination beam towards a tissue of an internal organ and for receiving the image beam from the internal organ;
an illumination optical fiber transmitting said illumination beam along said optical path from said IR scanning polarization unit to said optical probe;
an image optical fiber transmitting said image beam along said optical path from said optical probe to said IR scanning polarization unit;
a first polarizer within said optical probe between said illumination optical fiber and said transparent optical window for polarizing said illumination beam with a first polarization prior to transmission along said optical path onto the internal organ;
a second polarizer within said optical probe between said transparent optical window and said image optical fiber for polarizing with a second polarization said image beam received from the internal organ along said optical path prior to transmission to said image optical fiber,
said first and second polarizations being perpendicular to each other to reduce front surface scattering and increase depth of imaging,
said IR scanning polarization unit using said illumination beam having a wavelength anywhere within at least one of the following IR tissue optical windows: Window #1 (650 nm-950 nm); Window #2 (1,100 nm-1,350 nm); Window #3 (1,600 nm-1,870 nn) and Window #4 (2,100 nm-2300 nm),
said first and second polarizers being arranged to prevent transmission of said illumination beam with said first polarization from entering said image optical fiber while enabling transmission of said image beam with said second polarization into said image optical fiber;
and means for establishing and comparing the total attenuation lengths of said image beam for non-cancerous and cancerous tissues and determining that the tissue is likely to be cancerous when its total attenuation length is equal to or less than 50% of the attenuation length of non-cancerous tissue in a corresponding one of said at least one of said IR tissue optical windows.

US Pat. No. 10,362,981

DIAGNOSTIC METHODS AND SYSTEMS BASED ON URINE ANALYSIS

FLOWSENSE LTD., M.P. Mis...

1. A computer-implemented method for diagnosing a body malfunction, the method comprising:monitoring and detecting at least one change in urinary parameter values, the at least one change being indicative of the body malfunction, wherein one of the urinary parameter values comprises an oxygen level in the urine;
monitoring a volumetric urinary output of kidneys using a urine flow monitoring apparatus having a low flow metering device with a microprocessor, wherein the urine flow monitoring device further comprises a negative pressure tube which provides a continuous flow of urine through at least a portion of the urine flow monitoring apparatus;
determining, using the microprocessor, whether a change exists in a volume value of the volumetric urinary output and a trend of the corresponding urinary parameter value during a predetermined period;
receiving signals from a plurality of electrodes connected to the urine flow monitoring apparatus, the signals representing the urinary parameter values;
comparing, using the microprocessor, at least two occurrences of the trend of the received signals at an identical iteration during the predetermined period;
measuring, using the microprocessor, whether the change of the trend in at least two consecutive time periods exceeds a predetermined threshold in the urinary parameter values received from at least one of the plurality of electrodes; and
detecting, using the microprocessor, the body malfunction based on the determination of the change in the volume value of the volumetric urinary output, and the compared trend change of the corresponding urinary parameter value detected by the received signals during the predetermined period,
wherein the oxygen level is detected with an electrode from the plurality of electrodes.

US Pat. No. 10,362,979

APPARATUS FOR RECOGNIZING AND LOCATING EMOTIONS AND THOUGHTS BY MEASURING THE INFRARED PULSE RADIATION

1. A measuring device for recognizing and locating of feelings and thoughts by measuring an infrared pulse radiation comprising:a locating tube;
an infrared detector;
an amplifier;
an analogous/digital conversion;
an analysis program;
a display;
the locating tube receiving infrared pulses, caused by body heat changes of a living creature and radiated from a small body surface, and partly reflected several times on an inner wall and focused on the infrared detector;
the infrared detector which is designed so that it only can receive AC signals and no DC voltage signals, converts infrared radiation into electrical signals;
the amplifier amplifying the signals;
at the analogous/digital conversion the signals being digitized;
the analysis program creating time signals, amount spectra and difference spectra for an entire measurement time or time sections in various mental dispositions of the living creature and creating a characteristic spectrum in a mental pulse frequency range of about 0.01 to 10 Hz; and
on the display results being capable of being seen in different mental states of the living creature and being compared so that various emotions including joy and sadness are visible and so that thoughts are visible.

US Pat. No. 10,362,978

COMPUTATIONAL MODEL FOR MOOD

Comcast Cable Communicati...

1. A method comprising:receiving, by a first computing device, a first plurality of natural language inputs comprising a first natural language input and a second natural language input;
determining, based on a correlation between one or more terms in the first natural language input and one or more terms in the second natural language input, that the second natural language input comprises a repetition of a portion of the first natural language input;
associating, based on the second natural language input comprising the repetition of the portion of the first natural language input, a first mood state with the first plurality of natural language inputs;
determining, based on the first mood state, a first content service; and
causing, by the first computing device, output of the first content service.

US Pat. No. 10,362,977

SYSTEM AND METHOD FOR MEASURING REACTION TIME OF A SUBJECT

SWAY OPERATIONS, LLC, Al...

1. A method of measuring a reaction time in a subject, comprising the steps of:a. providing a handheld device to the subject, said handheld device having a motion sensor and a CPU integral thereto, wherein said CPU is in electronic communication with the motion sensor;
b. presenting a stimulus to the subject at a stimulus time after a selected random period of delay;
c. within the handheld device,
(c1) using said CPU to continuously read values from the motion sensor at least from said stimulus time until one or more of said continuously read motion values corresponds to an acceleration value greater than or equal to 0.1 g, thereby determining a time of a first substantial movement;
(c2) using said stimulus time, said time of said first substantial movement, and said continuously read motion values from said motion sensor to determine a time of a first significant movement that is earlier than said time of said first substantial movement, thereby determining the reaction time in the subject, wherein said time of said first significant movement is determined by:
(i) searching through said continuously read motion values in reverse order from said substantial movement time toward said stimulus time to find a first instance where, as between two adjacent continuously read motion values, an earlier measured one of said two adjacent continuously read motion values is greater than a later one of said two adjacent continuously read motion values, thereby determining a first significant movement, and
(ii) determining the reaction time of the subject to be a time of the first significant movement, and
(c3) using said CPU to report said reaction time of the subject.

US Pat. No. 10,362,976

STERILE FLUID COLLECTION TUBE PACKAGE

Boca Dental Supply, LLC, ...

1. A sterile fluid collection tube package, comprising:a fluid collection tube having first end and a second end;
a thermoformed tray formed from a first sterile material, the thermoformed tray comprising a flange having an upper surface, and a central region, wherein the central region defines a cavity surrounded by the flange, the cavity comprising:
a recessed portion comprising a rectangular section having a base wall, a first sidewall, a second sidewall, a third sidewall, and a fourth sidewall, the first sidewall and second sidewall are opposite, and the third sidewall and the fourth sidewall are opposite, the base wall is recessed with respect to the upper surface of the flange, and the first sidewall, the second sidewall, the third sidewall, and the fourth sidewall join the base wall to the flange;
a first support recess and a second support recess, the first support recess and the second support recess are aligned along a first common axis and are respectively located about the recessed portion to form a first compartment, wherein the first support recess is located at a first junction between the flange and the third sidewall, and the second support recess is located at a second junction between the flange and the fourth sidewall, a first interior surface of the first support recess is convex with respect to a plane formed by the upper surface of the flange and a second interior surface of the second support recess is convex with respect to the plane formed by the upper surface of the flange, wherein the fluid collection tube is located in the cavity, the first end of the fluid collection tube is located in the first support recess and the second end of the fluid collection tube is located in the second support recess; and
a cover formed from a second sterile material, the cover is attached to the upper surface of the flange, wherein the cover is sized to cover an entirety of the cavity and the fluid collection tube located therein.

US Pat. No. 10,362,973

SYSTEMS AND METHODS FOR MONITORING AND MANAGING LIFE OF A BATTERY IN AN ANALYTE SENSOR SYSTEM WORN BY A USER

DexCom, Inc., San Diego,...

1. A method for prolonging life of a battery installed in an analyte sensor system configured to be worn by a user comprising:measuring a first analyte value at a first time;
causing a transmission of the measured first analyte value along with a predicted second analyte value;
measuring a second analyte value at a second time;
calculating a difference between the measured second analyte value and the predicted second analyte value;
determining whether the calculated difference between the measured second analyte value and the predicted second analyte value is within a predefined range;
determining that a remaining power level of the battery is less than a predetermined power level; and
responsive to the determining that the remaining power level of the battery is less than the predetermined power level and determining that the calculated difference is within the predefined range,
skipping a transmission of the measured second analyte value,
wherein the predefined range is a variable predefined range that is determined based at least partly on a clinical error grid.

US Pat. No. 10,362,967

SYSTEMS AND METHODS FOR MISSED BREATH DETECTION AND INDICATION

Covidien LP, Mansfield, ...

1. A method implemented by a ventilator for determining missed breaths, the method comprising:ventilating a patient with the ventilator, wherein the ventilator includes a pneumatic system and at least one sensor;
monitoring respiratory data of the patient with the at least one sensor;
analyzing the respiratory data with a background trigger detection application and an active trigger detection application, wherein the background trigger detection application and the active trigger detection application are different and running at the same time;
detecting a first patient inspiratory effort with the active trigger application;
detecting a second patient inspiratory effort with the background trigger application;
comparing a first timing of the first patient inspiratory effort to a second timing of the second patient inspiratory effort;
determining a timing difference between the first patient inspiratory effort and the second inspiratory effort;
comparing the timing difference to a time delay threshold;
determining that the timing difference does not meet the time delay threshold to form a missed breath determination;
calculating a missed breaths metric based on the missed breath determination;
displaying a missed breath indicator based on the missed breaths metric; and
delivering inspiratory gas to the patient with the ventilator based on patient inspiratory efforts detected by the active trigger detection application and not based on patient inspiratory efforts detected by the background trigger detection application.

US Pat. No. 10,362,965

SYSTEM AND METHOD TO MAP STRUCTURES OF NASAL CAVITY

Acclarent, Inc., Irvine,...

1. An apparatus comprising:(a) a handle assembly, wherein the handle assembly comprises
(i) a body,
(ii) a cable configured to communicate an electrical signal to a navigation system, and
(iii) a first portion of an adapter coupled with a distal end of the cable;
(b) a guide tube extending distally from the handle assembly, wherein the guide tube has a distal end; and
(c) a cartridge assembly configured to be removably coupled with the handle assembly, wherein the cartridge assembly includes:
(i) an actuator, wherein the actuator is movable relative to the body to move the wire relative to the guide tube, and
(ii) a wire coupled with the actuator and configured to communicate an electrical signal to the cable, wherein the wire is slidably disposed in the guide tube, wherein the wire includes:
(A) a distal end including a sensor, wherein the distal end of the wire is configured to translate relative to the body,
(B) a proximal end that terminates at a second portion of the adapter, wherein the second portion of the adapter is configured to be removably coupled with the first portion of the adapter, wherein the proximal end is fixed relative to the body, and
(C) an intermediate portion configured to gather within the body as a service loop to provide freedom of movement of the distal end of the wire relative to the body as the distal end of the wire translates proximally relative to the body,
wherein the sensor is configured to cooperate with the navigation system to generate a map of anatomical structures within a patient.

US Pat. No. 10,362,963

CORRECTION OF SHIFT AND DRIFT IN IMPEDANCE-BASED MEDICAL DEVICE NAVIGATION USING MAGNETIC FIELD INFORMATION

ST. JUDE MEDICAL, ATRIAL ...

1. A system for navigating a medical device within a body, comprising:an electronic control unit configured to:
determine an operating position for a first electrical position sensor on said medical device within a first coordinate system, said first coordinate system defined by an electric field based positioning system;
determine an operating position for a first magnetic position sensor on said medical device within a second coordinate system, said second coordinate system defined by a magnetic field based positioning system, said first magnetic position sensor disposed proximate said first electrical position sensor;
apply a first mapping function correlating said operating positions of said first electrical position sensor and said first magnetic position sensor, said first mapping function generating a mapped position for said first magnetic position sensor in said first coordinate system responsive to said operating position of said first magnetic position sensor in said second coordinate system wherein said first mapping function describes a three-dimensional input and a three-dimensional output that generates said mapped position;
determine a first difference between said operating position for said first electrical position sensor and said mapped position for said first magnetic position sensor; and
modify said operating position for said first electrical position sensor by said first difference to obtain a first adjusted operating position;
wherein said electronic control unit is further configured to:
determine a planning position for said first electrical position sensor within said first coordinate system;
determine a planning position for said first magnetic position sensor within said second coordinate system;
compute said first mapping function responsive to said planning positions for said first electrical position sensor and said first magnetic position sensor; and,
responsive to the first adjusted operating position, displaying on a graphical user interface the first adjusted operating position of the first electrical position sensor of the medical device.

US Pat. No. 10,362,962

ACCOUNTING FOR SKIPPED IMAGING LOCATIONS DURING MOVEMENT OF AN ENDOLUMINAL IMAGING PROBE

SYNX-RX, LTD., Netanya (...

15. A method for use with an endoluminal data-acquisition device configured to acquire endoluminal data points while moving through a lumen of a subject's body, comprising:while the endoluminal data-acquisition device is being moved through the lumen, acquiring a plurality of endoluminal data points of the lumen using the endoluminal data-acquisition device, wherein the plurality of endoluminal data points comprise at least one of endoluminal imaging data or endoluminal functional data;
acquiring one or more extraluminal images of the lumen, using an extraluminal imaging device; and
using at least one processor:
coregistering the plurality of endoluminal data points to the one or more extraluminal images of the lumen, by determining, with respect to the one or more extraluminal images of the lumen, locations along the lumen at which respective endoluminal data points were acquired,
determining, with respect to the one or more extraluminal images of the lumen, that there is a given location within the lumen, at which no endoluminal data point was determined to have been acquired, based upon the coregistering of the plurality of endoluminal data points to the one or more extraluminal images of the lumen; and
generating an output, upon a display, using at least a portion of the plurality of endoluminal data points of the lumen acquired using the endoluminal data-acquisition device, the output including an indication that no endoluminal data point was determined to have been acquired at the location.

US Pat. No. 10,362,961

SYSTEM AND METHOD FOR NEUTRAL CONTRAST MAGNETIC RESONANCE IMAGING OF CALCIFICATIONS

NORTHSHORE UNIVERSITY HEA...

1. A method for producing an image of a subject using a magnetic resonance imaging (MRI) system, the steps of the method comprising:a) directing the MRI system to generate a radio frequency (RF) excitation field to excite spins in an imaging volume, the RF excitation field having a flip angle in a range from an Ernst angle for blood to an Ernst angle for muscle;
b) directing the MRI system to acquire data at an echo time at which spins associated with water are substantially in-phase with spins associated with fat;
c) reconstructing an image from the acquired data, the image in which water, fat, blood, and muscle tissues have substantially similar image intensity values and calcifications have image intensity values that are significantly different from the image intensity values of the water, fat, blood, and muscle tissues in the image.

US Pat. No. 10,362,957

SYSTEM AND METHODS FOR PERFORMING NEUROPHYSIOLOGIC ASSESSMENTS DURING SPINE SURGERY

NuVasive, Inc., San Dieg...

1. A system for performing neurophysiologic assessments during surgery, comprising:a first stimulator configured to deliver a first set of electrical stimulation signals to the motor cortex of a patient;
a first sensor configured to detect at least one motor evoked potential response evoked by the first set of electrical stimulation signals of the first stimulator;
a second stimulator configured to deliver a second set of electrical stimulation signals to a peripheral nerve of a patient;
a second sensor configured to detect at least one somatosensory evoked potential response evoked by the second set of electrical stimulation signals of the second stimulator; and
a control unit in communication with the first and second stimulators and the first and second sensors, the control unit being configured to (a) selectively operate in either trans-cranial electrical motor evoked potential (“MEP”) monitoring mode or somatosensory evoked potential (“SSEP”) monitoring mode; (b) accept user input to toggle between MEP monitoring mode and SSEP monitoring mode; (c) accept user input to initiate stimulation in the MEP monitoring mode or SSEP monitoring mode; and (d) communicate an onscreen assessment of a spinal cord health status to be displayed to a user in response to the potential response evoked by said first or second set of electrical stimulation signals.

US Pat. No. 10,362,955

GRAPHICALLY MAPPING ROTORS IN A HEART

Regents of the University...

1. A method, comprising:receiving, using a processor, an electrogram for each of a plurality of spatial locations in a heart, each electrogram comprising time series data including a plurality of electrical potential readings over time;
generating, from the time series data, a dataset, the dataset including a plurality of values using a mathematical approach, wherein the mathematical approach is either a multi-scale frequency (MSF) approach, a kurtosis approach, an empirical mode decomposition (EMD) approach, or a multi-scale entropy (MSE) approach; and
graphically indicating pivot points of rotors associated with atrial or ventricular fibrillation according to the dataset;
wherein the dataset is a first dataset, the plurality of values is a first plurality of values, and the mathematical approach is a first mathematical approach, and wherein the method further comprises:
generating, from the time series data, a second dataset, the second dataset including a second plurality of values using a second mathematical approach that is different from the first mathematical approach, wherein the second mathematical approach is either a multi-scale frequency (MSF) approach, a kurtosis approach, an empirical mode decomposition (EMD) approach, or a multi-scale entropy (MSE) approach depending on the first mathematical approach used; and
graphically indicating pivot points of rotors associated with atrial or ventricular fibrillation according to the second dataset.

US Pat. No. 10,362,951

NON-INVASIVE METHOD AND SYSTEM FOR CHARACTERIZING CARDIOVASCULAR SYSTEMS

Analytics For Life Inc., ...

1. A method of pre-processing data to extract variables for use in a machine learning operation to diagnose a pathology, the method comprising:receiving a biopotential signal data set associated with a subject, said biopotential signal data set being associated with a biopotential signal collected from one or more electrical leads;
generating, via a processor, an estimated noiseless model of the received biopotential signal data set, wherein generation comprises iterative selection of member atoms of a pre-defined dictionary of member atoms to form a sparse approximation of the received biopotential signal data set;
extracting, via the processor, a plurality of features from a low-energy complex sub-harmonic subspace derived from the estimated noiseless model, wherein one or more of the plurality of extracted features includes one or more fractional derivative derived features of the low-energy complex sub-harmonic subspace; and
linking, via the processor, the one or more of the plurality of extracted features to a genetic algorithm to generate outputs that correlate with clinical parameters describing tissue architecture, structure and/or function.

US Pat. No. 10,362,950

NON-INVASIVE METHOD AND SYSTEM FOR MEASURING MYOCARDIAL ISCHEMIA, STENOSIS IDENTIFICATION, LOCALIZATION AND FRACTIONAL FLOW RESERVE ESTIMATION

Analytics For Life Inc., ...

1. A method for non-invasively identifying and/or measuring or estimating a degree of myocardial ischemia, identifying one or more stenoses, and/or localizing and/or estimating fractional flow reserve, the method comprising:obtaining, by one or more processors, a data set associated with a plurality of wide-band gradient signals simultaneously from the subject via at least one electrode;
generating, by the one or more processors, a residue subspace data set and a noise subspace data set from the data set associated with the plurality of wide-band gradient signals;
determining, via the one or more processors, one or more coronary physiological parameters of the subject selected from the group consisting of a fractional flow reserve estimation, a stenosis value, and a myocardial ischemia estimation, based on the residue subspace data set and the noise subspace data set; and
output, via one or more of an output data set in a report and/or a display, the one or more coronary physiological parameters, wherein the output is used in the diagnosis of cardiac disease.

US Pat. No. 10,362,949

AUTOMATIC EXTRACTION OF DISEASE-SPECIFIC FEATURES FROM DOPPLER IMAGES

International Business Ma...

1. A method for automatic extraction of disease-specific features from Doppler images, comprising:obtaining a raw Doppler image from a series of images of an echocardiogram;
isolating a region of interest from the raw Doppler image, the region of interest (i) including a Doppler image and an electrocardiogram (ECG) signal, and (ii) depicting at least one heart cycle;
determining a velocity envelope of the Doppler image in the region of interest;extracting the electrocardiogram (ECG) signal by detecting the electrocardiogram (ECG) signal using an energy maximization equation:E(i,j)=?1Econtinuity(i,j)+?2Ecolor(i,j)+?3Egradient(i,j)+?4Enotgray(i,j)
wherein E(i,j) is an energy value, Econtinuity(i,j) is a continuity of the electrocardiogram (ECG) signal, Ecolor(i,j) is a color profile of the electrocardiogram (ECG) signal, Egradient(i,j) is a gradient between the color profile of the electrocardiogram (ECG) signal and a background of the image, Enotgray(i,j) is RGB value of the electrocardiogram (ECG) signal that is not gray, and each of, ?1, ?2, ?3, and ?4 is a weighting factor, and
synchronizing the extracted the electrocardiogram (ECG) signal with the Doppler image over the at least one heart cycle, within the region of interest;
calculating a value of a clinical feature based on the extracted the electrocardiogram (ECG) signal synchronized with the velocity envelope; and
comparing the value of the clinical feature with clinical guidelines associated with the clinical feature to determine a diagnosis of a disease.

US Pat. No. 10,362,946

MEASUREMENT OF CARDIAC CYCLE LENGTH AND PRESSURE METRICS FROM PULMONARY ARTERIAL PRESSURE

Medtronic, Inc., Minneap...

21. A computer readable medium comprising computer executable instructions that, when executed, cause a processor of an implantable medical device to:control sensing of the cardiovascular pressure signal;
compare the sensed cardiovascular pressure signal to a first threshold;
identify a first sense in response to the sensed cardiovascular pressure signal exceeding the first threshold;
in response to and as a result of identifying the first sense, compare the sensed cardiovascular pressure signal to a second threshold not equal to the first threshold;
identify a second sense subsequent to the first sense if the sensed cardiovascular pressure signal exceeds the second threshold;
identify a third sense subsequent to the first sense and in response to the sensed cardiovascular pressure signal exceeding the first threshold; and
determine a cardiac cycle length based on one of the first sense and the third sense or the second sense and the third sense.

US Pat. No. 10,362,945

METHOD AND DEVICE FOR ASCERTAINING A BLOOD PRESSURE CURVE

CIS FORSCHUNGSINSTITUT FU...

1. A method for ascertaining the time-dependent curve of the blood pressure including the following steps:noninvasive detection of time-dependent and volume-dependent blood flow values, in the form of photoplethysmographic values P(t), in a section of tissue with blood circulation by means of a photoplethysmographically functioning sensor;
transformation of the photoplethysmographic values P(t) into blood pressure values B(t) through the use of the following transformation formula by means of a data processing unit:

determining the time interval between the occurrences of the first two peaks in the curve of the transformed blood pressure values B(t) within a signal period by means of the data processing unit;
outputting of the transformed blood pressure values B(t) as time-dependent blood pressure values to a display and/or memory unit; and
generating a warning signal if the time interval falls below a predetermined minimum time interval in order to signal a critical blood pressure by means of a signal output unit.

US Pat. No. 10,362,944

OPTICAL DETECTION AND ANALYSIS OF INTERNAL BODY TISSUES

Samsung Electronics Compa...

1. An electronic device comprising:a band;
one or more light sources coupled to the band and configured to emit light in a first direction that penetrates into a portion of a user's body;
a plurality of light sensors coupled to the band and configured to detect a pattern of diffusion of the emitted light, wherein:
at least one first light sensor is located near the light source and configured to detect light travelling in a second direction that is between 90 degrees and 270 degrees from the first direction;
at least one second light sensor located between 90 degrees and 270 degrees from the light source and configured to detect light travelling between 90 degrees and ?90 degrees from the first direction; and
the one or more light sources and the plurality of light sensors are positioned in a matrix configuration comprising a plurality of rows of light sensors with the one or more light sources interspersed within the matrix configuration; and
a controller configured to detect a gesture made by the user based on the detected pattern of diffusion of the emitted light by cycling through different configurations of active light sources of the one or more light sources of the matrix configuration.

US Pat. No. 10,362,943

DYNAMIC OVERLAY OF ANATOMY FROM ANGIOGRAPHY TO FLUOROSCOPY

Siemens Healthcare GmbH, ...

1. A method for generating an overlay of anatomy in a fluoroscopy image, the method comprising:acquiring, with an angiograph, an angiograph image representing the anatomy of a patient at a first phase of a first cardiac cycle of the patient;
acquiring, with a fluoroscope, a fluoroscopic image representing the anatomy of the patient at a first phase of a second cardiac cycle of the patient;
determining, by a processor, a shape of the anatomy in the fluoroscopic image from the angiograph image; and
generating the overlay of the anatomy as a graphic on the fluoroscopic image, the overlay being a function of the shape determined from the angiograph image.

US Pat. No. 10,362,942

MICROMETER SIZE MULTI-FUNCTIONAL PROBE FOR OCT AND ELECTRO-PHYSIOLOGICAL RECORDING

1. A probe for tissue recording in a medical procedure, comprising:a flexible optical fiber for optical coherence tomography imaging, having an optical fiber distal end, an optical fiber proximal end and an optical fiber length extending from the optical fiber distal end to the optical fiber proximal end;
a metal coating surrounding the optical fiber length for recording electrical signals, having a metal coating distal end and a metal coating proximal end;
an electrophysiological recording system connected to the metal coating proximal end; and
an outer insulation coating surrounding the metal coating, wherein the insulation coating is discontinuous in proximity to the metal coating distal end, thereby providing contact between the metal coating and the tissue for receiving an electrical signal from the tissue.

US Pat. No. 10,362,938

FUNDUS IMAGE FORMING DEVICE

NIKON CORPORATION, Tokyo...

1. A fundus imaging system configured to scan a retina of a subject with a light beam, the system comprising:a reflection mirror configured to reflect a light beam incident on the reflection mirror after passing through a first focus so as to cause the light beam to pass through a second focus;
a two-dimensional scanning unit that is disposed at a position that coincides with a position of the first focus of the reflection mirror and configured to reflect a light beam incident on the two-dimensional scanning unit so as to perform scanning with the light beam in two-dimensional directions;
a detecting unit configured to detect a light beam reflected off the retina; and
a compensating unit configured to correct a detection result of an intensity of the light beam detected by the detecting unit, based on at least one of a scan angle or a scan timing at which the two-dimensional scanning unit performs scanning, so as to compensate for illuminance non-uniformity of the light beam illuminating the retina, the illuminance non-uniformity resulting from an unevenness of a ratio of an angular change of a light beam emitted from the first focus during scanning of the two-dimensional scanning unit to an angular change of a light beam incident on the second focus after being reflected by the reflection mirror.

US Pat. No. 10,362,936

METHODS OF PERFORMING SURGERY USING OPTICAL COHERENCE TOMOGRAPHY (OCT)

Bioptigen, Inc., Morrisv...

1. A method for performing a surgical procedure using an optical coherence tomography (OCT) imaging system, the method comprising:imaging a surgical region of the subject that contains a structure having a known orientational asymmetry to obtain an OCT image using the OCT imaging system;
testing the OCT image for presence and location of the structure;
confirming correct orientation of the subject using the OCT image of the structure having the known orientational asymmetry;
obtaining at least one image of the surgical region of the subject using OCT and constructing an initial structural view of the surgical region;
computing at least one clinical parameter relevant as an end point for assessing an outcome of the surgical procedure using data derived from the OCT image;
periodically assessing the surgical procedure progression and monitoring clinical outcomes related to the surgical procedure using changes to an OCT-derived structural view of the surgical region and changes to the computed clinical parameters derived from the at least one OCT image;
determining if a surgical plan for the surgical procedure needs modification based on at least one of the periodically assessing and monitoring;
modifying the surgical plan for the surgical procedure in real time if it is determined modification is needed; and
repeatedly assessing and monitoring, determining and modifying until it is determined that further modification is not needed,
wherein computing clinical parameters for the surgical procedure comprises computing at least one of a cornea thickness, a cornea curvature, a lens thickness, a lens curvature, a cornea refractive power, a lens refractive power, an iridocorneal angle, a sclera thickness, a conjunctival thickness, a direction of an optical axis, an orientation of a refractive astigmatism, a thickness of a an edema, a length of a tissue membrane or tear, a width of a surgical incision, a map or a count of surgical debris within a surgical field, a map or measure of degree of contact between an implanted device and surrounding tissue, and orientation of an implanted device relative to a neighboring structure or an optical or physical axis; and,
wherein the computing includes computing from measurements derived from the at least one image.

US Pat. No. 10,362,934

SYSTEM AND METHOD FOR THE RAPID MEASUREMENT OF THE VISUAL CONTRAST SENSITIVITY FUNCTION

1. A method for implementing a tilted-grating, forced choice contrast sensitivity function test, the method comprising the steps of:presenting a patient with a first series of randomized test chart sets having patterns with two or more choices per set on a high resolution display of 10 bit depth or greater as a video and covering a first range of frequencies and contrasts, the high resolution display being shielded from ambient light that interferes with the test and connected to a processor and associated memory for implementing an algorithm for the contrast sensitivity function test, and wherein the algorithm ensures that the test charts are sized to maintain a predetermined viewing distance between the patient and the display;
having the patient select a response from the two or more choices, automatically recording if the response is correct or incorrect and the time for the patient to make the selection, and providing the patient with additional choices until the first series of test charts are complete and a contrast sensitivity function is generated to a desired precision based upon an analysis of the responses;
analyzing the responses utilizing statistical methods;
providing the patient with an ophthalmic solution to increase visual performance based upon the analyzed results;
repeating the method until a desired ophthalmic resolution is obtained as determined by an adaptive algorithm; and
storing and plotting the contrast sensitivity function to provide an accurate quantitative result for the contrast sensitivity function.

US Pat. No. 10,362,930

ENDOSCOPE APPARATUS

OLYMPUS CORPORATION, Tok...

1. An endoscope apparatus comprising:a light source configured to emit one of white illumination light and narrow band illumination light, the white illumination light including red wavelength band light, green wavelength band light, and blue wavelength band light, and the narrow band illumination light having a narrow wavelength band included in each of the blue wavelength band light and the green wavelength band light;
an image sensor having a plurality of pixels, wherein each pixel is configured to receive light, the plurality of pixels being arranged in a lattice pattern, and the image sensor being configured to perform photoelectric conversion on the light received by each of the plurality of pixels to generate an electric signal;
a color filter comprising a filter unit arranged corresponding to the plurality of pixels, the filter unit including a plurality of filters having at least a filter for passing the blue wavelength band light, and a filter for passing the blue wavelength band light and at least one of the green wavelength band light and the red wavelength band light, the number of the filters for passing the green wavelength band light being equal to or greater than half of the number of all the filters of the filter unit, and the number of the filters for passing the blue wavelength band light being equal to or greater than the number of the filters for passing the green wavelength band light; and
a hardware processor configured to:
select, from the plurality of pixels, a luminance component pixel for receiving light of a luminance component, wherein the luminance component is among a plurality of color components, and the selection of the luminance component pixel is based on a control signal indicating a type of illumination light emitted by the light source;
generate a luminance component value based on a pixel value of the selected luminance component pixel;
generate at least one color component value based on the generated luminance component value, wherein the at least one color component value correspond to color components different from the luminance component; and
generate a color image signal, based on the generated luminance component value and the generated color component values, wherein the color image signal corresponds to an image comprising pixels that includes the luminance component.

US Pat. No. 10,362,927

ENDOSCOPE WITH PANNABLE CAMERA

DEKA Products Limited Par...

1. An endoscope having a proximal handle assembly and a distal insertion shaft; the insertion shaft having a distal portion that includes a camera assembly; the insertion shaft comprising a liquid carrying conduit;the camera assembly comprising an electronic image sensor;
the proximal handle assembly comprising a proximal housing and a distal housing;
the distal housing and the insertion shaft connected together and rotatable together relative to the proximal housing;
the liquid carrying conduit including a wired connection extending from the camera assembly to a printed circuit board attached to the distal housing, the wired connection being exposed to any liquids carried by the conduit; wherein
the proximal housing of the handle assembly comprises a liquid passageway in fluid communication with the liquid carrying conduit of the insertion shaft.

US Pat. No. 10,362,926

LOW-COST INSTRUMENT FOR ENDOSCOPICALLY GUIDED OPERATIVE PROCEDURES

CooperSurgical, Inc., Tr...

1. An endoscopic device, comprising:a single-use portion, comprising:
an elongate conduit comprising a proximal portion and comprising a distal portion configured for insertion into a uterus of a patient, the distal portion defining a distal opening through which fluid can be delivered to the uterus,
an imaging system disposed along the distal portion of the elongate conduit for imaging the uterus,
an electrical cable extending from the proximal portion of the elongate conduit to the imaging system,
a fluid hub connected to the proximal portion of the elongate conduit, the fluid hub comprising a fluid connection port and a gasket at which a first seal is provided, and
a sliding connector attached to a proximal end of the fluid hub that isolates fluid to the single-use portion, the sliding connector comprising:
an outer shell, and
a fluid barrier disposed within the outer shell and surrounding the electrical cable, wherein the fluid barrier and the electrical cable together form a second seal at a distal end of the fluid barrier, and wherein the fluid barrier and the electrical cable together form a third seal located proximal to the second seal and along a radial projection of the electrical cable that seats within a radial recess of the fluid barrier; and
a multiple-use portion configured to be attached to and detached from the single-use portion, the multiple-use portion comprising:
a handle coupled to the proximal end of the outer shell of the sliding connector and being located proximal to the sliding connector and to the fluid hub such that the handle, the sliding connector, the fluid hub, and the elongate conduit are arranged in an in-line configuration, and
an integral image display located proximal to the handle and electrically coupled to the imaging system by the electrical cable.

US Pat. No. 10,362,925

DOSING DEVICE FOR DISPENSING A WASHING AGENT IN A WASHING MACHINE, IN PARTICULAR A DISH WASHING MACHINE

BITRON S.P.A., Turin (IT...

1. A dosing device for dispensing doses of a washing agent, towards a washing chamber of a washing machine, comprising:a hollow body oscillatable between a loading position and a vertical, operating position, and in which there are defined:
a main chamber adapted to contain an amount of said washing agent corresponding to a plurality of doses, and
a dosing chamber adapted to contain a volume of washing agent substantially corresponding to one dose, coming from the main chamber; and
an electrically controlled valve obturator driven in each cycle of operation of the machine by a first short pulse for the actuation of another function, and thereafter with a subsequent second long pulse in order to put the dosing chamber in communication with the main chamber and thereafter cause the dispensing of a dose of washing agent from the dosing chamber towards the washing chamber,
wherein in the hollow body there are further defined:
an auxiliary chamber adapted to contain an amount of said washing agent corresponding to a multiplicity of doses, and
an intermediate chamber comprising an upper end and a lower end, the intermediate chamber being disposed between the auxiliary chamber and the dosing chamber, and communicating permanently with the auxiliary chamber at the lower end of the intermediate chamber,
wherein a communication passage is defined between the intermediate chamber and the dosing chamber, wherein the dosing chamber comprises a dispensing opening, and wherein said valve obturator is movable in the dosing chamber between a position opening, and a second position in which the valve obturator opens said communication passage and closes said dispensing opening,
wherein the communication passage is located at the upper end of the intermediate chamber, under a top wall delimiting the upper end of the intermediate chamber,
wherein the intermediate chamber is adapted to:
trap an air bubble when said hollow body oscillates from the loading position to the vertical, operating position, and
discharge a washing agent contained therein towards said auxiliary chamber when the hollow body oscillates from the vertical, operating position to the loading position, and
wherein said valve obturator controls the communication between the intermediate chamber and the dosing chamber such that said first pulse causes the intermediate chamber to be put in communication with the dosing chamber for a short time, causing a partial discharge of said air bubble from the intermediate chamber to the dosing chamber and a corresponding increase of the amount of washing agent contained in the intermediate chamber, and said second pulse causes the intermediate chamber to be put in communication with the dosing chamber for a relatively longer time, sufficient to allow the storing of a dose of washing agent in the dosing chamber and, when said second pulse is over, the dispensing of said dose of washing agent stored in the dosing chamber.

US Pat. No. 10,362,924

JET UNIT, JET NOZZLE AND MANUFACTURING METHOD THEREOF, AND DISH WASHING MACHINE HAVING THE SAME

SAMSUNG ELECTRONICS CO., ...

1. A dish washing machine comprising:a cabinet configured to form an exterior;
a washing tub provided in the cabinet to wash dishes; and
a jet nozzle configured to jet washing water to the washing tub,
wherein the jet nozzle comprises a plurality of inner walls of a passage through which the washing water passes, and at least one of the plurality of inner walls has a cross sectional area formed in an arc shape that is convex in an outer circumferential direction of the jet nozzle, and
wherein the plurality of nozzle inner walls extends to the end of the jet nozzle for linearity of the washing water sprayed from the jet nozzle.

US Pat. No. 10,362,923

VALVE FOR A SPRAY ARM OF A DISHWASHER APPLIANCE

Haier US Appliance Soluti...

1. A dishwasher appliance defining a lateral direction, a transverse direction, and a vertical direction, the lateral, transverse, and directions mutually perpendicular to one another, the dishwasher appliance comprising:a cabinet defining a wash chamber for receipt of articles for washing;
a spray arm disposed within the wash chamber, the spray arm defining an interior and an aperture providing selective fluid communication between the interior and the wash chamber;
a valve positioned within the interior of the spray arm;
a sensor operable to detect a pressure of a fluid flowing from a pump of the dishwasher appliance to the interior of the spray arm; and
a controller communicatively coupled to the sensor, the controller configured to determine a rotational speed of the spray arm based, at least in part, on the detected pressure of the fluid,
wherein the spray arm is rotatable between a first position wherein the valve allows fluid communication between the interior and the wash chamber through the aperture, and a second position wherein the valve obstructs fluid communication between the interior and the wash chamber through the aperture.

US Pat. No. 10,362,921

CLEANER

LG ELECTRONICS INC., Seo...

1. A cleaner, comprising:a cleaner body having a controller;
a wheel cover mounted to the cleaner body;
a motor that is connected to the wheel cover and generates a driving force;
a wheel that is coupled to the motor and rotates based on receiving the driving force from the motor;
a guide bar coupled to the wheel cover and extending vertically, the guide bar being connected to the motor to guide a vertical movement of the motor;
a spring surrounding the guide bar and connected to the wheel cover and the motor to absorb impacts during the vertical motion of the motor;
a case having a through-hole into which the guide bar is inserted, the motor being mounted on the case such that a movement of the case along the guide bar guides the vertical movement of the motor; and
a planetary gear train that connects the motor and the wheel, the planetary gear train receiving the driving force from the motor and transferring the driving force to the wheel,
wherein a rotating shaft of the motor and the wheel are coaxially arranged.

US Pat. No. 10,362,919

CLEANING ROBOT AND METHOD FOR CONTROLLING THE SAME

SAMSUNG ELECTRONICS CO., ...

1. A cleaning robot comprising:a main body;
a moving assembly mounted on a bottom surface of the main body to perform forward movement to move the main body in a first direction that is a traveling direction of the main body, backward movement to move the main body in a second direction opposite to the first direction, and rotation to rotate the main body within a predetermined range to change the traveling direction of the main body;
a cleaning tool assembly mounted on the bottom surface of the main body to clean a floor;
a detector to detect an obstacle around the main body; and
a controller to determine whether an obstacle is present in front of the main body in the traveling direction based on a detection signal of the detector, control the rotation of the main body to determine whether the main body rotates by an angle equal to or greater than a predetermined angle upon determining that the obstacle is present, and determine that the main body is in a stuck state to control the backward movement of the main body when the main body rotates by an angle less than the predetermined angle.

US Pat. No. 10,362,918

SELF-PROPELLED AND SELF-STEERING FLOOR CLEANER AND METHOD FOR CLEANING A FLOOR SURFACE

robart GmbH, Linz (AT)

1. A self-propelled and self-steering floor cleaner comprising a cleaning device with at least one cleaning unit for cleaning a floor surface of a room, at least a section or sections of an obstacle located inside the room not being in contact with the floor surface, the obstacle being of such low height that the floor cleaner cannot move under the obstacle, the floor cleaner further comprising a transmission unit for emitting radiation directed at the obstacle and the floor surface, in order to spatially scan these, a detection unit for detecting reflected radiation and providing a detection signal relating thereto, a control unit coupled to the detection unit, and a chassis for movement on the floor surface comprising a drive unit coupled to the control unit, it being determinable by the control unit from the detection signal whether a space is present between the obstacle and the floor surface, if so, a floor surface section located underneath the obstacle being regarded as cleanable, and the drive unit being actuatable to move the floor cleaner for cleaning the floor surface section, with at least one cleaning unit reaching into the space,wherein the drive unit is actuatable to move the floor cleaner during cleaning of the floor surface section at a predetermined or predeterminable distance from the obstacle.

US Pat. No. 10,362,915

VACUUM CLEANER

LG Electronics Inc., Seo...

1. A vacuum cleaner comprising:a cleaner body;
a pair of wheels provided at both side surfaces of the cleaner body and configured to rotate about a rotating center; and
a rear wheel unit provided at a bottom surface of the cleaner body and configured to provide an upward elastic force at a position rearward of the rotating center of the pair of wheels,
wherein the cleaner body is configured to pivot about the rotating center and has a center of gravity that is located closer to a rear end of the cleaner body than the rotating center,
wherein the rear wheel unit includes:
a supporting part that is rotatably coupled to the bottom surface of the cleaner body and configured to rotate in a pivoting direction of the cleaner body,
an elastic portion that is coupled to the supporting part and that is configured to be elastically deformed based on the supporting part being rotated,
a rotating member that is rotatably coupled to the supporting part and configured to rotate in a direction that is transverse to the rotating direction of the supporting part, and
a rear wheel that is provided at the rotating member and configured to roll on ground.

US Pat. No. 10,362,913

CLEANING APPARATUS DATA MANAGEMENT SYSTEM AND METHOD

Diversey, Inc., Fort Mil...

1. A mobile cleaning machine comprising:a chassis;
a communications module configured to communicate with a device remote from the mobile cleaning machine;
a sensor operable to sense one or more characteristics of the mobile cleaning machine; and
a controller including a processor and memory, the processor programmed to perform instructions stored in the memory, the instructions including
receiving the one or more characteristics of the mobile cleaning machine sensed by the sensor,
receiving a non-mobile cleaning machine data set from the remote device, and
transmitting, via the communications module, at least one of the one or more characteristics of the mobile cleaning machine and the non-mobile cleaning machine data set to a central location.

US Pat. No. 10,362,904

FOOD PROCESSOR SYSTEM

SHARKNINJA OPERATING LLC,...

1. A base for a food processing system, comprising: a housing configured to couple with a complementary container, the housing including a bottom surface;at least one suction device mounted to the bottom surface, the at least one suction device being configured to adhere the base to an adjacent surface; and
at least one release mechanism operably coupled to the at least one suction device, the at least one release mechanism being movable between a first position and a second position to apply a vertical force to an outer periphery of the at least one suction device to release the at least one suction device from the adjacent surface, wherein an exterior surface of the at least one release mechanism arranged generally flush with an outer surface of the housing in both the first position and the second position, wherein the at least one release mechanism includes a first release mechanism and a second release mechanism disposed at opposing sides of the base, respectively.

US Pat. No. 10,362,899

BARBECUE GRILL ACCESSORY AND METHOD FOR PREPARING FOOD

Adrenaline Barbecue Compa...

1. A grilling insert adapted for use in a barbecue grill having a recessed cooking chamber, said grilling insert comprising:a double-wall thermal barrier adapted for extending across the recessed cooking chamber of the barbecue grill, and dividing the cooking chamber into direct-heating and indirect-heating cooking sections, and said thermal barrier comprising a chordal water reservoir designed to extend from one point on a circular interior of the recessed cooking chamber to an opposite point, and wherein said thermal barrier has an asymmetrical V-shaped vertical cross-section with a first vertical wall of said thermal barrier being longer than a second vertical wall of said thermal barrier; and
a radiant heat chamber adjacent said double-wall thermal barrier, and designed for holding loose combustible material within the direct-heating cooking section of the barbecue grill, such that cooking temperature in the direct-heating cooking section is relatively high, and is reduced in the indirect-heating cooking section by said double-wall thermal barrier, and said radiant heat chamber comprising a vertical downwardly tapered peripheral wall curving between opposite ends of said thermal barrier and designed to reside proximate an interior surface of the barbecue grill, and said peripheral wall cooperating with said thermal barrier to define a relatively large open top of said heat chamber and a comparatively small bottom of said heat chamber.

US Pat. No. 10,362,892

SYSTEM AND APPARATUS FOR REGULATING FLOW RATE IN AN ESPRESSO MACHINE

Seattle Espresso Machine ...

1. A brew flow rate regulation assembly for regulating a brew flow rate of pressurized water within an espresso machine while brewing a coffee beverage having coffee grounds using the pressurized water, comprising:an assembly body;
a brew regulation assembly input configured and arranged to allow flow of the pressurized water into the assembly body;
a brew regulation assembly output configured and arranged to allow flow of the pressurized water out of the assembly body;
a first flow path disposed in the assembly body and in fluid communication with the brew regulation assembly input and the brew regulation assembly output, wherein the first flow path is configured and arranged to receive at least a portion of the pressurized water;
a second flow path disposed in the assembly body and in fluid communication with the brew regulation assembly input and the brew regulation assembly output, wherein the second flow path is configured and arranged to receive at least another portion of the pressurized water;
a first adjustable valve configured and arranged to regulate the brew flow rate of the pressurized water within the espresso machine by restricting a first flow rate through the first flow path, the first adjustable valve configured to regulate the pressurized water to pre-wet the coffee grounds at the first flow rate within a first time interval and with a first volume of pressurized water, the combination of the first flow rate, the first time interval, and the first volume of pressurized water insufficient to extract the pressurized water through the coffee grounds to produce the coffee beverage;
a second adjustable valve configured and arranged to regulate the brew flow rate of the pressurized water within the espresso machine by restricting a second flow rate though the second flow path, the second adjustable valve configured to regulate the brew flow rate of the pressurized water to the first flow rate during pre-wetting of the coffee grounds and configured to regulate a second volume of pressurized water at a second flow rate within a second time interval to extract the pressurized water through the coffee grounds to produce the coffee beverage;
wherein the brew flow rate of the pressurized water is equal to at least a sum of the first flow rate and the second flow rate; and
controls for the brew regulation assembly configured to adjustably control the first valve and/or the second valve to vary continuously and transition between two or more positions such that the brew flow rate of the pressurized water is adjustable during the espresso brewing process to vary pressure of pressurized water along the respective first flow path and/or the second flow path, the controls for the brew regulation assembly comprising a rotatable handle or adjustment knob.

US Pat. No. 10,362,891

PRESSURE-COOKING UTENSIL PROVIDED WITH A LOCKING/UNLOCKING CONTROL MEMBER THAT OPERATES ASYMMETRICALLY

SEB S.A, Ecully (FR)

1. A food-cooking utensil comprising:a vessel and a lid;
locking/unlocking means mounted to move between a locked position in which the locking/unlocking means lock the lid to the vessel and an unlocked position in which the lid is free relative to the vessel; and
a control member for controlling the movement of the locking/unlocking means, the control member being mounted to enable a user to move the control member back and forth between (i) a locking position, which causes the locking/unlocking means to move to the locked position in which the locking/unlocking means lock the lid to the vessel, and (ii) an unlocking position, which causes the locking/unlocking means to move to the unlocked position in which the lid is free relative to the vessel, the unlocking position of the control member being a stable position in which the control member remains in the stable position without the user interacting with the control member and until force is applied manually to move the control member out of said stable position,
wherein while the control member is being moved from its locking position towards its unlocking position, the control member and the locking/unlocking means co-operate so that the instantaneous position of the locking/unlocking means varies as a function of the instantaneous position of the control member in a first relationship,
wherein while the control member is being moved from its unlocking position towards its locking position, the control member and the locking/unlocking means co-operate so that the instantaneous position of the locking/unlocking means varies as a function of the instantaneous position of the control member in a second relationship that is different from the first relationship, and
wherein in the second relationship in which the control member is being moved from its unlocking position towards its locking position, the locking/unlocking means remains stationary in its unlocked position until the control member reaches its locking position and, upon the control member reaching its locking position from its unlocking position, the control member causes the locking/unlocking means to move into its locked position from its stationary unlocked position to lock the lid to the vessel.

US Pat. No. 10,362,890

METHOD FOR SIMULTANEOUSLY PEELING AND CUTTING COOKED VEGETABLES

Hosam Khalil Smiley, New...

1. A method for peeling, and cutting a cooked root vegetable comprising providing a cooked root vegetable having flesh and skin wherein same has been cut in half to provide cut surfaces; placing said cut in half and cooked root vegetable on a movable surface with the cut surface facing upward, said surface existing within a frame, said frame having front, rear and side surfaces so as to receive the cut in half and cooked root vegetable, said surface associated with the frame to enable said surface to move within the frame linearly and reciprocally along at least a portion of the height of the frame; fixing a mesh plate to the frame above said surface, the mesh plate oriented perpendicular to the movement of said surface; and providing power to enable said surface to move toward the mesh plate, whereby said surface moves the cut in half and cooked root vegetable through the mesh plate, such that said flesh of the cut in half and cooked vegetable is cut and the skin remains behind the mesh plate after all of said flesh has been fed through said mesh plate.

US Pat. No. 10,362,889

RECEPTACLE FOR RECEIVING AND SECURING PACKAGES AND OTHER ITEMS

BENCHSENTRY INC., Little...

1. A receptacle that is positionable on a porch or other area of a home and that is configured for securing a package, the receptacle comprising:a bottom panel;
four side panels that are coupled with the bottom panel and that are coupled together to form an exterior wall that extends upward from the bottom panel and that defines an interior space within which the package is positionable, wherein opposing ends of each panel of said four side panels include at least one interfacing member having a through hole, the interfacing members being arranged so that as the ends of the four side panels are assembled, the through holes of adjacent interfacing members are axially offset, and wherein said four side panels are coupled together via insertion of a rigid rod member through the through holes of the adjacent interfacing members, wherein said insertion of said rigid rod member axially aligns the through holes of the adjacent interfacing members and thereby increases a mating engagement of adjacent side panels and increases a rigidity of the receptacle;
a lid that is pivotably coupled with a back panel of said four side panels via a hinge mechanism, the lid being configured to cover an opening at a top end of the receptacle to enclose the package within the interior space, wherein the lid is configured to be pivoted open to enable the package to be removed from the interior space, and wherein the hinge mechanism is positioned relative to said four side panels so that a pivot point of the hinge mechanism is positioned above a top surface of the lid and is positioned forward of a rear surface of the back panel; and
a lock mechanism that is operably coupled with the lid and the exterior wall of the receptacle, the lock mechanism having a locked state in which the lid is locked and secured about the top end of the receptacle to prevent user access to the interior space and the lock mechanism having an unlocked state in which the lid is pivotable open to allow user access to the interior space; wherein:
a seam between each adjacent panel is covered and concealed by a component of the exterior wall so that the seam is not readily user accessible;
a vertical lip of the lid overlaps at least three sides of the top end of the exterior wall so that a seam between the lid and the top end of the exterior wall is covered by the lip.

US Pat. No. 10,362,887

APPARATUSES AND METHODS FOR PLACING A COVERING ABOUT A MATTRESS

Russo Inventions, LLC, G...

1. A tool for manipulating a bed covering, comprising:a proximal handle portion;
a distal end portion comprising a plurality of spaced-apart protrusions extending outwardly therefrom, wherein the spaced-apart protrusions are configured to engage and extend through a plurality of openings in said bed covering to manipulate said bed covering; and
end stop portions disposed directly adjacent to the spaced-apart protrusions sized and configured for abutting with said bed covering adjacent to the openings of said bed covering to limit how far the protrusions can extend through the openings.

US Pat. No. 10,362,883

UNITARY, CONTINUOUS AND LINEAR APPARATUS HAVING DUAL FUNCTIONALITY FOR TRANSPORTING AND SECURING COVER TO A SEATING OR RESTING DEVICE

Leann L. Bellini, Dixon,...

1. An apparatus for transporting a cover and for securing said cover to a seating or resting device comprising:a) a linear strap, wherein said linear strap further comprising:
i) a left strap,
ii) a stabilizing pad, wherein said stabilizing pad further comprises a first quilt stitching and a second quilt stitching, and
iii) a right strap,
b) a first fastening means for engaging a first end of said linear strap to said linear strap to form a first closed-loop of variable size to secure towel during transportation,
c) a second fastening means for engaging a second end of said linear strap to said linear strap to form a second closed-loop of variable size for use as a transportation sling, and
d) a variable coupling means for configuring said linear strap into a third closed-loop of variable size for securing said cover disposed on said seating or resting device.

US Pat. No. 10,362,881

COLLAPSIBLE, FOLDING MATTRESS SUPPORT WITH A HEADBOARD AND A FOOTBOARD THAT FOLD OUT

Best Price Mattress Inc.,...

1. A foldable mattress support comprising:a bedboard frame with a first portion and a second portion;
a central hinge portion that is pivotally attached to the first portion and the second portion;
a headboard frame; and
means for rotating the headboard frame from a collapsed state that is parallel and adjacent to the first portion to an unfolded state that is perpendicular to the first portion without pivoting the headboard frame about any axis whose position is fixed with respect to the first portion.

US Pat. No. 10,362,879

BED FRAME ASSEMBLED BY SLIDING THE ENDS OF HOLLOW METAL BARS INTO NARROW SLOTS CUT INTO OTHER METAL BARS

Zinus Inc., Tracy, CA (U...

1. A mattress support comprising:a first hollow bar with a rectangular cross section, a first end and a first slot, wherein the first hollow bar is made from metal having a first thickness;
a second hollow bar with a rectangular cross section, wherein a second slot is disposed in two adjacent sides of the second hollow bar, wherein the second slot has a first width that is greater than the first thickness but less than twice the first thickness, wherein a third slot is disposed in the two adjacent sides of the second hollow bar, and wherein the first end of the first hollow bar is adapted to be inserted into the second slot; and
a third hollow bar with a rectangular cross section and a top end, wherein the third hollow bar is made from metal having a second thickness, wherein the third slot has a second width that is greater than the second thickness but less than twice the second thickness, and wherein the top end of the third hollow bar is adapted to be inserted into the first slot and the third slot.

US Pat. No. 10,362,878

FOLDABLE SOFA-BED

Ultra-Mek, Inc., Denton,...

1. A seating unit that includes a foldable bed, the seating unit comprising:a base with an internal cavity;
a foldable bed that includes separate and distinct head, intermediate and seat sections, wherein in a folded position, the intermediate and seat sections are generally horizontally disposed and positioned in vertically stacked relationship, and the head section is generally vertically disposed and positioned adjacent a rear portion of the base, with an outer surface of a cushion of the head section facing rearwardly to form a rear surface of the seating unit, and in an unfolded position, the head, intermediate and seat sections are generally horizontally disposed and in serial alignment with each other, with the outer surface of the cushion of the head section facing upwardly; and
a bed folding mechanism that is attached to the base and the head, intermediate and seat sections that controls the movement of the bed between the folded and unfolded positions.

US Pat. No. 10,362,876

CHAIR

OKAMURA CORPORATION, Kan...

1. A chair comprising:an installation base which is mounted on or fixed to an installation surface and includes a tilting allowance hole;
a leg column which stands upward from the installation base and is supported by the installation base in a tiltable manner;
a seat body which is supported on an upper part of the leg column to receive a seating load of an occupant;
an elastic member which is interposed between the leg column and the installation base and urges the leg column to take a vertical posture which is an initial tilted posture;
a support wall which supports the elastic member on the installation base and has an insertion hole; and
a coming-off restriction portion which penetrates the support wall from below to restrict coming-off of the leg column from the installation base,
wherein, in the support wall of the installation base, part of the coming-off restriction portion is inserted through the insertion hole, and a slide guide coming into slidable contact with a lower surface of a peripheral edge portion of the insertion hole of the coming-off restriction portion is provided, and
the coming-off restriction portion has a spherical guide surface which upwardly protrudes and comes into slidable contact with the slide guide below the insertion hole.

US Pat. No. 10,362,875

EASY FOLDING CROSS BRACE DESIGN

GCI OUTDOOR, INC., Higga...

1. An apparatus comprising:first and second U-shaped cross-members, each of said cross-members including a front portion, a rear portion, and a cross bar perpendicularly connecting the front portion to the rear portion, wherein the respective front portions of the first and second cross-members are pivotally connected with each other at central portions thereof and the respective rear portions of said cross-members are pivotally connected with each other at central portions thereof,
wherein the cross-members are mutually movable from a generally X-shaped set-up condition in which the cross bars of the first and second cross-members are transversely spaced apart, to a generally flat collapsed condition in which the cross bars of the first and second cross-members are generally adjacent one another; and
right and left frame side assemblies are pivotally connected to each of the first and second cross-members, wherein at least one of the right and left frame side assemblies is pivotally connected to one of the first and second cross-members by a lost motion linkage;
wherein said lost motion linkage comprises a longitudinal link having a first end pivotally connected to one of the first and second cross-members via a first pivot pin and a second end pivotally connected to the at least one of the right and left frame side assemblies via a second pivot pin, said longitudinal link further comprising a slot extending partially along a length of the link proximate at least one of the first end and the second end and in which the first pivot pin or the second pivot pin is received for sliding movement within said slot with movement of the cross-members between the set-up condition and the collapsed condition.

US Pat. No. 10,362,872

FOLDING DRAWER FOR CABINET

E-MAKE CO., LTD., Taichu...

1. A folding drawer for cabinet, comprising:a bottom board including a plurality of holes in a front end;
two side panels each including a plurality of holes in a front end, a slide on an outer surface, and an L-shaped positioning member on a top of a rear end;
a rear panel including two U-shaped grooves on two sides respectively, and two flexible projections each adjacent to the U-shaped groove wherein the L-shaped positioning member is configured to dispose in the U-shaped groove;
a front panel including a plurality of holes in a lower portion of a rear surface;
a plurality of pins each having two ends fitted in either the hole of the front panel and the hole of the bottom board respectively or the hole of the front panel and the hole of either side panel respectively; and
first, second and third hinges wherein the first hinge is disposed on a joining portion of a rear surface of the rear panel and a bottom of the bottom board, the second hinge is disposed on a joining portion of an inner surface of one side panel and a top of the bottom board, and the third hinge is disposed on a joining portion of an inner surface of the other side panel and the top of the bottom board.

US Pat. No. 10,362,871

DEVICE AND METHOD FOR FIXING A PUSH ELEMENT

1. A device for fixing a push element to a rail (5) of a pull-out guide (3), comprising:a clamping mechanism with a receptacle (20);
a holding part (12) securable in the receptacle,
a device for depth adjustment for the push element (4), and
a self-locking clamping element (25) provided on the receptacle (20), by means of which the holding part (12) is frictionally secured against being pulled out,
wherein the device (11) for depth adjustment has a stop (100) which can be adjusted on or in the receptacle (20).

US Pat. No. 10,362,866

METHODS FOR CONTROLLED DISPENSING

Cubex LLC, Phoenix, AZ (...

1. A method for selective actuation, comprising: translating an index plate in a first direction in proximity to a plurality of bins arranged relative to one another in a plurality of columns of bins and each having a corresponding trigger release arm, wherein the index plate defines a plane having a perimeter border and a plurality of protrusions extending from a surface of the plate entirely within the perimeter border of the plane such that the plurality of protrusions are non-planar relative to the index plate and where the plurality of protrusions define a plurality of rows arranged upon the plate in a collinear arrangement; aligning a single protrusion to a single trigger release arm along the first direction; and translating the index plate in a second direction transverse to the first direction such that the single protrusion engages with the single trigger release arm and actuates a preselected bin which corresponds to the single trigger release arm, wherein the plurality of protrusions further define a plurality of columns which are arranged upon the plate at an angle relative to a proximal or distal edge of the plate such that each protrusion is off-set relative to an adjacent protrusion along the plurality of columns of protrusions which are further arranged to actuate alternating columns from the plurality of columns of bins for dispensing.

US Pat. No. 10,362,862

RAILING SUPPORTED BUFFET

1. A rail-mounted buffet mountable to a railing having a top rail and one or more vertical balusters, the rail-mounted buffet comprising:a main bar buffet section having a flat surface area for supporting items on the main bar buffet section;
a U-shaped channel located on an underside of the main bar buffet formed between a back-side member and a front side member, wherein the back-side member and front side member are movable in relation to one another such that a width of the U-shaped channel is adjustable, and wherein a position of the front side member relative to the backside member may be fixed in varying locations such that a width of the U-shaped channel is adjustably fixed;
a trust support having a first end and a second end, the trust support attached to the underside of the main bar buffet at the first end of the trust support;
a baluster support comprising a clamshell formed of a first clam shell portion engaged with a second clam shell such that the baluster support fits around one of the one or more balusters, the baluster support attached to the second end of the trust support.

US Pat. No. 10,362,858

METHOD OF MANUFACTURING A BRUSH AND BRUSH

BRAUN GMBH, Kronberg (DE...

1. A method of manufacturing a toothbrush, comprising the steps of:providing a carrier having at least a first through hole extending from a front side to a backside of the carrier and at least a first wall element being integral with the carrier and extending from the backside in a vicinity of the first through hole;
introducing a first cleaning element into the first through hole such that an end portion of the first cleaning element is exposed on the backside of the carrier;
treating the end portion of the first cleaning element such that it deforms and becomes wider than the first through hole; and thereafter
deforming the first wall element until it at least partially extends over the deformed end portion of the first cleaning element such that the first cleaning element is effectively retained in its axial position, wherein the step of deforming the first wall element is performed after the step of treating the end portion of the first cleaning element.

US Pat. No. 10,362,853

SWIVEL LIP APPLICATOR

CONCEPT WORKSHOP WORLDWID...

1. An applicator comprising:a body having a first top surface including an opening, a channel extending through the body away from the opening of the first top surface, and a first side and a second side including a first slot and a second slot respectively cut through the first and second sides;
a cover having a second top surface, a first arm and a second arm extending away from the second top surface, and a first and second hinges installed on the first and second arms respectively;
a support cup having a side wall, an inner-body opening configured to receive a product, and first and second recesses inscribed on opposite sides of the side wall; and
an indentation or hole on at least one of the first and second sides of the body and a peg on at least one of the corresponding first and second arms of the cover such that when the indentation or hole engages with the peg, the cover is prevented from moving longitudinally with respect to the body,
wherein the support cup is slidably fitted inside the channel of the body and the cover is hingedly coupled to the body via the first and second hinges of the cover,
wherein the first and second hinges protrude through the first and second slots of the body and engage with the first and second recesses of the support cup, respectively, and the cover and the support cup are slidable together in a longitudinal direction along the channel of the body, and
wherein the body is configured to allow the cover and support cup to slide in the longitudinal direction only after the cover is rotated away from a position in which the opening is covered.

US Pat. No. 10,362,852

ERGONOMIC MANICURING SUPPORT

Lori Ellen Halloway, Sal...

1. An ergonomic manicuring support apparatus comprising:an angled ramp including a top edge, a bottom edge wider in length than the top edge and opposing side edges extending between the bottom edge and the top edge, wherein the angled ramp is configured to receive and support at least one forearm and at least one wrist of a user;
a platform including a top edge, a bottom edge wider in length than the top edge and connected to the top edge of the angled ramp and opposing side edges extending between the bottom edge and the top edge, wherein the platform is configured to receive and support at least one hand of the user;
at least one contoured convex hand support disposed proximate at least one opposing side edge of the platform, wherein the at least one contoured convex hand support is configured to support and prevent movement of the at least one hand of the user;
a pair of legs connected to and supporting the angled ramp and the platform, wherein the pair of legs are connected to a portion of the platform to allow the top edge of the platform to extend from the legs; and
support brackets extending between the pair of legs to structurally reinforce the angled ramp and the platform,
wherein the at least one forearm, wrist and hand of the user are positioned and supported by the angled ramp and at least one contoured convex hand support on the platform to elevate the at least one wrist and the at least one hand of the user and position one or more fingers of the user in a hanging downward position relative to the top edge of the platform to receive manicuring services.

US Pat. No. 10,362,847

LENS FOR PROTECTIVE CASE

Otter Products, LLC, For...

1. A protective case for an electronic device having a camera and a microphone, the protective case including a lens assembly comprising:a transparent lens having a first side configured to face the electronic device and at least partially cover the camera when the electronic device is installed in the protective case and a second side opposite the first side; wherein a first portion of the first side and a second portion of the second side are each coated with a light-blocking material and a first optically transparent portion of the first side and a second optically transparent portion of the second side are uncoated; the second optically transparent portion having an area greater than an area of the first optically transparent portion; and
a water-resistant membrane attached to the transparent lens and configured to cover the microphone of the installed electronic device.

US Pat. No. 10,362,844

MOVABLE DECORATIVE ELEMENTS

CHOPARD TECHNOLOGIES SA, ...

1. A decorative article comprising a movable decorative element which is freely mounted in rotation and translation between two walls (5, 6) whose inner faces are parallel to each other, at least one of which is transparent, the decorative element including a precious or semi-precious stone (2) mounted in a socket (1), the socket (1) including:a closed bottom (4), having an outer face (7) which is applied in contact against the inner face of one of said walls, with one of the contacting faces bulged to promote the rotation of the decorative element, and
an open outer face (7) opposite to the bottom (4) which is flush with or protrudes relative to the stone (2) to form a bearing surface against the other of said walls (5, 6),
characterized in that the precious or semi-precious stone (2) is held in said socket (1) by a plurality of arms (3) integral with the socket (1) and extend above a body (8) of the socket (1) terminating at a free end, crimp the stone (2), the body (8) of the socket with said plurality of integral arms (3) being closed by said closed bottom whose outer face in contact with said inner face of the other of said walls promotes the rotation of the decorative element, said arms (3) leaving, therebetween and above the body (8) of the socket (1), lateral openings (9) which are rotatable with the socket (1) and which let appear flanks of the stone (2) between the arms (3) during rotation of the decorative element, and said bearing surface is constituted by free ends of said arms (3) in the form of separate contact areas spaced from each other around the open outer face (7) of the socket (1) about a periphery thereof, the free ends of said plurality of arms (3) being able to come to bear against the other of said walls when the decorative element rotates and translates between the two walls.

US Pat. No. 10,362,841

ORNAMENT

MARIND CO., LTD., Osaka-...

1. An ornament comprising:an ornament body which is provided with a receiving portion;
a pivot shaft provided in erect fashion, and engaging the receiving portion in such manner that only a bottom end portion of the pivot shaft makes contact with said receiving portion;
a rigid suspending arm portion that protrudes from a top end portion of said pivot shaft; and
a jewelry member supported by a lower portion of said suspending arm portion;
wherein said pivot shaft, said suspending arm portion, and the jewelry member supported in pendant fashion by the lower portion of said suspending arm portion are formed in integral fashion; and
said pivot shaft is capable of swinging about a contact point of said receiving portion.

US Pat. No. 10,362,837

CLOSURE APPARATUS

Fastech Asia Worldwide, L...

1. A closure comprising:a male closure member comprising:
a first loop;
an arm fixedly attached to the first loop;
a bar fixedly attached to the arm, the bar having an upper portion extending orthogonally from the arm in a first direction and a lower portion extending orthogonally from the arm in a second direction opposite the first direction; and
a first loop extension fixedly attached to the first loop and extending orthogonally from the first loop in the second direction; and
a female closure member comprising:
a second loop; and
a base portion fixedly attached to the second loop, the base portion comprising:
a top edge;
a bottom edge;
a blind hole extending from the top edge toward the bottom edge into which the bar of the male closure member is insertable at the top edge and moveable along and configured for rotational pivoting of the bar in the blind hole;
a resilient protrusion disposed in and extending from the base portion at a position proximal to the bottom edge and configured to secure the first loop extension upon insertion and rotation of the bar in the blind hole; and
a recess configured to receive the arm attached to the bar inserted in the blind hole and positioned such that the upper portion of the bar and the lower portion of the bar are disposed between the top edge and the bottom edge.

US Pat. No. 10,362,831

CYCLING SHOE

SELLE ROYAL S.P.A., Pozz...

1. A cycling shoe, comprising a sole provided with an upper face and a lower face, as well as an upper that rises up from said sole, wherein the surface of said upper comprises a plurality of recesses suitable for decreasing the form drag of said upper hit by air, wherein said sole comprises a heelpiece comprising a channeling, for conveying the air that hits the shoe through a predetermined path, in order to reduce the form drag, wherein said channeling comprises a first branch and a second branch which are not open at the upper face of the sole and which are open, respectively, at a first air inlet opening and at a second air inlet opening provided for in the lower face of the sole and on the opposite sides of the heelpiece, and wherein the first branch and the second branch communicate with a single rear discharge of the heelpiece, and wherein the heelpiece does not project with respect to the lower face of the sole, so as to define a continuous surface alongside the lower face of the sole.

US Pat. No. 10,362,827

HEADGEAR ACCESSORY ATTACHMENT APPARATUS

Bryan Family Enterprises ...

1. A helmet accessory attachment apparatus adapted to be secured to the helmet, the helmet accessory attachment apparatus comprising:a band member comprising a central opening for receiving the helmet and at least one size adjustment member for adjusting the size of the flexible band member from a resting configuration, to an active configuration when the band member is fitted onto the helmet and the size adjustment feature is locked;
an accessory connector located on the band member for mounting a helmet accessory to the band member;
wherein the band member is sufficiently flexible to be manipulated from a floppy state in the resting configuration to a taut state in which the band member forms a secure clamp around a front edge of the helmet when the band member is fitted about the helmet and the size adjustment feature is locked, thereby prohibiting the apparatus from rising or rotating upwards on the helmet.

US Pat. No. 10,362,823

EYELASH EXTENSION CASE

Jessica Hill, Philadelph...

1. An eyelash extension case, comprising:an enclosure body defining a first internal region for storage of one or more eyelash extensions; and
a lid operative to cover the first internal region in a closed state and open to allow access to the first internal region in an open state;
wherein internal wall surfaces of the first internal region form a floor, and one or more eyelash extension retaining features,
each eyelash extension retaining feature including a protrusion that extends outward from the floor toward the lid along an axis,
each protrusion having curved wall surfaces that transition into the floor, and each protrusion having curved wall surfaces that define an outer profile of the protrusion surrounding the axis, and
wherein at least a portion of each protrusion is formed from a self-adhesive super-gel material to retain the one or more eyelash extensions
wherein the enclosure body is formed from two enclosure body halves that collectively define a second internal region.

US Pat. No. 10,362,821

OPENABLE GIFT PACKAGING DEVICE

Imprint Diamond Corp., S...

1. A gift packaging device comprising:a support device including a support member, a bore formed in said support member;
a stem slidably received and engaged through said bore of said support member and moveable up and down relative to said support member, said stem including an upper portion located above said support member,
a carrier member disposed on said stem for supporting a gift,
a plurality of flaps pivotally attached to said support member and rotateable relative to said support member between a folded position where the gift is covered and shielded with said flaps, and an opened position where the gift is viewable, and
a plurality of links coupled between said stem and said flaps for allowing said flaps to be rotated relative to said support member between said folded position and said opened position when said stem is moved relative to said support member of said support device, wherein
said support member includes a plurality of protrusions extended from said support member, and said flaps each include a stud pivotally attached to said protrusions of said support member.

US Pat. No. 10,362,818

UTILITY GLOVE

MADGRIP HOLDINGS, LLC, E...

1. A method of manufacturing a utility glove having a thumb, four fingers and a main body, said glove comprising a three dimensional molded portion, the molded portion comprising an elastomeric material bonded to a fabric material in a three dimensional configuration substantially conforming to three dimensional contours of at least a portion of a hand exclusive of any variations in thickness or features on the surface of the molded portion, comprising the steps of:a. placing a glove blank comprising a fabric material over a first mold part in the form of at least a portion of a hand;
b. bringing a second mold part into molding engagement with the first mold part to create a cavity with only a portion of the glove blank on the first mold part; and
c. injecting an elastomeric material into the cavity to form a molded portion, said molded portion having a thickness of from about 0.8 mm to about 10.8 mm with the elastomeric material on the fabric of the molded portion having a thickness of from about 0.4 mm to about 10.0 mm, wherein the elastomeric material of the molded portion is integrally formed to continuously extend up to and including 360° about the main body of the glove while leaving a portion of the fabric material of the glove blank without elastomeric material entirely surrounded by the molded portion.

US Pat. No. 10,362,817

MULTI-USE GARMENT

1. A multi-use garment comprising:a torsal portion configured to be worn over a torso having a bottom edge configured to be adjacent a waist of a wearer when worn;
a pair of sleeve portions attached to the torsal portion, wherein each sleeve portion is configured to accommodate at least a part of an arm;
a pair of separate leg portions attached to the torsal portion, wherein each leg portion is configured to accommodate at least a part of a leg, wherein each leg portion has a first end adjacent the torsal portion and a second end remote from the torsal portion;
a pair of fasteners attached to the second end of each of the pair of leg portions,
wherein each fastener is configured to create a completely closed bottom edge of the torsal portion;
wherein each fastener of the pair of fasteners is at least one of the following: a zipper, a snap button fastener, a hook and loop fastener, a drawstring, a pair of drawstrings; and
wherein each fastener of the pair of fasteners is configured to create a completely closed bottom edge of the torsal portion so that, in one configuration of the multi-use garment, each leg portion is entirely drawn into an inner space of the torsal portion thus closing off the entire bottom edge of the multi-use garment wherein nothing projects from the bottom edge of the multi-use garment and the multi-use garment is capable of being used as a storage bag or a sleeping bag.

US Pat. No. 10,362,815

ANTI-GRIP KIMONO

Lime Enterprises Limited,...

1. A reinforced martial arts kimono containing anti-grip reinforced panels which pop-off or release from the grip of an opponent grabbing the reinforced martial arts kimono, the reinforced martial arts kimono comprising:a kimono jacket that is formed from a first material;
the kimono jacket including right sleeve and right body portions;
the kimono further including left sleeve and left body portions and a collar;
the collar extending upwardly from upper ends of each of the left and right sleeves;
the right body portion includes an inner flap and the left body portion includes an outer flap;
each body portion includes a lapel which is contiguous with the collar;
the lapels extending downwardly from the collar toward the bottom of the kimono jacket;
wherein the lapel and inner flap of the right body portion extends under the lapel of the left body portion toward a left side of the wearer of the kimono jacket and the lapel and the outer flap of the left body portion extends over the inner flap of the right body portion and extends toward a right side of the wearer of the kimono jacket;
and the lapels and body portions are configured to be kept in place by a martial arts belt;
at least two anti-grip reinforcement panels affixed to an inside surface of the interior of the reinforced martial arts kimono;
the at least two reinforcement panels being located on the inside of the kimono form annular-shaped anti-grip reinforcement panels and the at least two reinforced panels are affixed to the inside of the sleeves of the reinforced anti-grip martial arts kimono jacket, adjacent to the cuffs of the each of the sleeves;
the at least two anti-grip reinforcement panels being of a second material which is different material than the first material forming the kimono jacket, the two reinforcement panels providing a sufficient popping-off tactile sensation or release of grip of an opponent grabbing the reinforced anti-grip martial arts kimono during the practice of martial arts;
and
wherein the second material adjacent to the cuff of each of the left and right sleeves extends from the cuff upwardly toward the collar of the anti-grip martial arts kimono jacket.

US Pat. No. 10,362,811

SOCK WITH SUPPORT ASSEMBLAGE

SOKSYSTEM, LLC, Beverly ...

1. A sock, comprising:a sock body defined by a toe section, a heel flap, a sole extending between the toe section and the heel flap on a bottom portion of the sock, and an instep extending between the toe section and the heel flap on a top portion of the sock, the toe section and the instep having a first elasticity coefficient;
an arch support assemblage, situated below the instep, in front of the heel flap, and behind the toe, the arch support assemblage adapted to cover an arch region of the sole of the sock excluding the toe section of the sock, the arch support assemblage having a second elasticity coefficient, wherein the second elasticity coefficient is lower than the first elasticity coefficient such that the arch support assemblage is stiffer than the toe, the heel flap, the instep, and the leg of the sock; and
an Achilles support assemblage, adapted to cover an Achilles tendon of a wearer of the sock when worn, the Achilles support assemblage running from a top edge of the heel flap to a top portion of a leg of the sock.

US Pat. No. 10,362,805

WICKLESS CARTOMIZER

Intrepid Brands, LLC, Lo...

1. A wickless cartomizer comprising:(a) a base;
(b) an outer wall extending from the base;
(c) an inner wall extending from the base;
(d) a vapor exit opening defined by the inner wall;
(e) a heating element disposed in the inner wall; and
an electrical connector disposed in the base, wherein the electrical connector is electrically coupled with the heating element.

US Pat. No. 10,362,795

COLLAPSIBLE FOOD PREPARATION DEVICE

Alan Backus, Los Angeles...

1. A food preparation device using heated air, comprising:a heat source configured to heat air to food preparation temperatures;
a base enclosure configured to contain the heat source;
a first tray, stacked above the base enclosure, and including a generally flat floor configured to support foods to be processed, the floor being perforated to allow air passage from one side of the floor to the other side of the floor;
the floor being generally rectangular and comprising four generally straight edges;
the floor includes four generally planar hinged side walls, one each hinged to each of the four generally straight edges;
each of the four hinged side walls configured to rotate about its associated hinge axes from a generally horizontal disposition to a generally vertical disposition;
a second tray having substantially the same construction as the first tray,
the second tray configured to stack above the first tray when the four hinged side walls on the first tray are in their generally vertical dispositions;
wherein, when the heat source is activated during food preparation, the four hinged side walls on the first tray and the four hinged side walls on the second tray which is stacked above the first tray, are each in their vertical dispositions; and
wherein, when the heat source is not activated, and the device is not preparing food the four hinged side walls on the first tray and the four hinged side walls on the second tray are each oriented in their horizontal dispositions.

US Pat. No. 10,362,780

OXYGEN SUPPLY FOR ORGAN PERFUSION SYSTEMS

Organox Limited, Oxford ...

1. A perfusion system for the perfusion of an organ, the system comprising:a perfusion fluid circuit for circulating perfusion fluid through the organ;
an oxygenator for adding oxygen into the perfusion fluid, the oxygenator comprising a duct to carry the perfusion fluid, an oxygen chamber, and a permeable membrane between the duct and the oxygen chamber;
an oxygen supply arranged to supply oxygen to the oxygenator, wherein the oxygen supply comprises an oxygen concentrator, the oxygen concentrator comprising an inlet arranged to receive gas in the form of air, a compressor arranged in the inlet, and a nitrogen extractor arranged to extract nitrogen from the gas thereby to increase the oxygen concentration of the gas;
an air supply arranged to supply air to the oxygenator;
a carbon dioxide sensor arranged to measure a carbon dioxide content of the perfusion fluid;
an air control valve arranged to control the flow rate of air from an air supply to the oxygen chamber;
an oxygen control valve arranged to control the flow rate of oxygen from the oxygen concentrator to the oxygen chamber;
an oxygen sensor arranged to measure an oxygen content of the perfusion fluid; and
a controller arranged to define a first target range for said oxygen content, monitor the measured oxygen content and to control the oxygen control valve and the compressor in response to the measured oxygen content thereby to maintain the oxygen content within the first target range, and to define a second target range for said carbon dioxide content, to monitor the measured carbon dioxide content and to control the air control valve in response to the measured carbon dioxide content thereby to maintain the carbon dioxide content within the second target range.

US Pat. No. 10,362,773

AUTOMATIC RETRACTABLE FLOAT

RETRACT A FLOAT PTY LTD.,...

1. An automatic retractable float comprising:a body which floats in water;
the body comprising two halves connected to a central portion;
the central portion having a top handle, a pair of side handles and a line housing disposed about the outer surface, with a depression located under each side handle,
wherein about the outer surface of the central portion the line housing is positioned substantially opposite the top handle and the side handles are positioned substantially opposite each other such that each side handle is approximately midway between the top handle and the line housing and
wherein the line housing includes a conduit that passes through the outer surface of the central portion and provides access to an interior of the body;
each of the two halves having a pair of depressions positioned such that when each half is attached to the central portion, the pair of depressions are joined with the corresponding depression under each side handle;
an automatic retraction and extension mechanism contained within the interior of the body, the automatic retraction and extension mechanism including a spring mechanism for automatically extending and retracting a line from the body; and
at least one electronic device in communication with a mobile device such that the electronic device shares information or data with the mobile device.

US Pat. No. 10,362,765

PET TOY WITH SQUEAKER MECHANISM

Otomik Products, Inc., C...

1. An animal toy, comprising:a body member defining a cavity and including a sidewall, the sidewall defining a first opening in fluid communication with the cavity, the sidewall defining a second opening in fluid communication with the cavity, the first and second openings being disposed on an outer periphery of the body member, the first opening being different than the second opening; and
a squeaker member defining a lumen and configured to produce a sound in response to air passing through the lumen, the squeaker member being coupled to the body member such that at least a portion of the squeaker member is disposed within the cavity defined by the body member, the squeaker member including a switch configured to be moved from a first position to a second position, the switch being configured to prevent passing of air through the lumen when the switch is in the first position.

US Pat. No. 10,362,735

HARVESTING ATTACHMENT FOR A HARVESTER

BISO Schrattenecker GmbH,...

1. A harvesting attachment having a frame comprising:an elongated rear wall formed as an extrusion profile;
an elongated base wall formed as an extrusion profile;
an elongated curved connection wall curved in cross section formed as an extrusion profile;
wherein each of said rear wall, base wall and curved connection wall have a front wall and a back wall.

US Pat. No. 10,362,722

SOIL PROCESSING DEVICE

REDEXIM HANDEL-EN EXPLOIT...

1. A mobile soil working device comprising:a machine frame,
a drive,
at least one support arm configured to be movable up and down by the drive and pivotably supported by the machine frame,
at least one insertion tool configured to be pivotable relative to the support arm about a first pivot axis and movable in an upward direction and a downward direction by the support arm, the insertion tool adapted to be inserted into the soil and pulled from the soil,
wherein, prior to insertion into the soil, the insertion tool is configured to be disposed in an initial position under a predefined insertion angle, and is configured to carry out a pivot movement from the initial position, the pivot movement being superposed over up-and-down movement of the insertion tool, about the first pivot axis in a first pivoting direction in the soil on the basis of movement of the machine frame in a direction of travel,
at least one returning mechanism which is coupled to the machine frame at a first end and to the insertion tool at a second end, the returning mechanism having a first biasing element and a second biasing element, wherein the first biasing element is a returning element configured to move the insertion tool back into the initial position by pivoting the insertion tool in a second pivoting direction opposite the first pivoting direction after the insertion tool exits the soil,
wherein the second biasing element is an independent spring device in addition to the returning element, said spring device allowing the insertion tool to be pivoted in the second pivoting direction beyond the initial position such that the insertion tool is pivoted in the second pivoting direction beyond the initial position upon hitting a hard object in the soil.

US Pat. No. 10,362,721

TILLAGE DEVICE FOR AGRICULTURAL MACHINERY OR IMPLEMENTS TO REDUCE COMPACTION CAUSED BY WHEELS IN A FIELD

AGRICULTURE CONCEPTS, LLC...

1. A system for tilling compression marks formed in soil of a field by agricultural machinery or equipment having a plurality of compaction forming members, the system comprising:a plurality of roller assemblies;
each of the plurality of roller assemblies having a plurality of blade assemblies positioned in spaced relation to one another;
each of the plurality of roller assemblies operatively connected to a frame member;
a plurality of row units;
wherein the plurality of row units are configured to plant seeds in the soil of the field;
wherein each of the plurality of roller assemblies are positioned between a pair of adjacent row units configured to plant seeds in the soil of the field;
wherein the plurality of roller assemblies are configured to rotate;
a movement device connected to each of the plurality of roller assemblies wherein when activated the movement device moves the associated roller assembly between a disengaged position, where the roller assembly does not penetrate the soil, and an engaged position, where the roller assembly does penetrate and till the soil;
each of the plurality of roller assemblies each having at least one guard positioned in spaced relation to the associated roller assembly;
wherein each guard is configured to deflect dirt that is kicked up during the tilling process;
wherein the plurality of roller assemblies are positioned behind and in alignment with a plurality of compaction forming members of the agricultural machinery or equipment;
wherein when the agricultural machinery or equipment moves through the field the compaction forming members form compression marks in the soil of the field;
wherein when in an engaged position, when the agricultural machinery or equipment moves through the field, the plurality of roller assemblies till the compression marks formed by the compaction forming members;
wherein when in an engaged position, when the agricultural machinery or equipment moves through the field, the plurality of roller assemblies till the compression marks formed by the compaction forming members the at least one guard associated with each roller assembly deflects dirt that is kicked up during the tilling process;
wherein positioning each of the plurality of roller assemblies behind and in alignment with a compaction forming member of the agricultural machinery or equipment facilitates tilling of the area behind and in alignment with the aligned compaction forming member while leaving the area between the compaction forming members untilled;
wherein the at least one guard associated with each roller assembly is configured to prevent dirt kicked up during the tilling process from landing outside of the tilled area which is behind and in alignment with the aligned compaction forming member.
US Pat. No. 10,363,300

FMDV AND E2 FUSION PROTEINS AND USES THEREOF

BOEHRINGER INGELHEIM ANIM...

1. A method of vaccinating a host susceptible to ovine, bovine, caprine, or swine Foot-and-Mouth Disease Virus (FMDV), or protecting or preventing the host against FMDV infection, or eliciting a protective immune response in a host, comprising at least one administration of a composition or vaccine comprising an FMDV antigen or polypeptide; wherein the FMDV antigen or polypeptide has at least 90% sequence identity to a polypeptide having the sequence as set forth in SEQ ID NO:2, 4, 6, 8, 10, 12 or 14.
US Pat. No. 10,362,789

METHOD FOR CONTROLLING PESTS

SUMITOMO CHEMICAL COMPANY...

1. A method for controlling a weed in a field of soybean, corn or cotton, comprising applying at least one PPO-inhibiting compound selected from the group consisting of sulfentrazone, saflufenacil, and fomesafen-sodium to a field before, at or after seeding with a seed of soybean, corn or cotton treated with one or more nematicides selected from the group consisting of abamectin and Bacillus firmus.
US Pat. No. 10,363,303

MICRONEEDLE COMPOSITIONS AND METHODS OF USING SAME

VERNDARI, INC., Sacramen...

1. A microneedle device for administering a polypeptide, comprising:(a) a dehydrated composition comprising the polypeptide; and
(b) a substrate comprising a sheet and a plurality of microneedles extending therefrom, each microneedle of the plurality of microneedles comprising a tip, a base, a hinge at the base connecting the microneedle to the sheet, and a well comprising the dehydrated composition.
US Pat. No. 10,363,308

SELECTIVELY ALTERING MICROBIOTA FOR IMMUNE MODULATION

SNIPR Technologies Limite...

1. A method for treating a cancer in a patient, wherein the method comprises(a) exposing a microbiota in the patient to a guided nuclease to selectively target the genome of cells of a first species in the microbiota using the guided nuclease, wherein the first species is a bacterial or archaeal species; and simultaneously or sequentially administering to the patient an effective amount of an immunotherapy; and
(b) allowing the guided nuclease to cut one or more target nucleotide sequences comprised by first cells of a first strain of the first species, thereby killing the first cells or reducing the growth thereof, whereby the proportion of the first cells comprised by the microbiota is reduced;wherein(c) the selective targeting avoids targeting second cells comprised by the microbiota, wherein the second cells are of a different strain or a different species from the first cells; and
(d) the reducing of the proportion of the first cells modulates immune cells in the patient, whereby the efficacy of the immunotherapy is enhanced for treatment of the cancer in the patient.
US Pat. No. 10,364,332

HIGH TG EPOXY FORMULATION WITH GOOD THERMAL PROPERTIES

ISOLA USA CORP., Chandle...

1. A prepreg comprising a b-staged varnish composition including:a multi-functional epoxy wherein the multi-functional resin is not an eight-functional bisphenol-A novolac epoxy resin;
an eight-functional bisphenol-A novolac epoxy resin;
a bifunctional epoxy resin;
a hardener selected from 4,4?-diaminodiphenylsulfone, 3,3?-diaminodiphenylsulfone and mixtures thereof; and
decabromodiphenylethane wherein the prepreg is capable of being c-staged to a composite having a DMA Tg in excess of 280° C. and a T288 time in excess of 20 minutes.
US Pat. No. 10,363,314

SPRAYABLE TOPICAL CARRIER AND COMPOSITION COMPRISING PHOSPHATIDYLCHOLINE

LIPIDOR AB, Stockholm (S...

1. Pharmaceutical or cosmetic carrier for topical administration, said carrier comprisingfrom 2%-40% by weight of phosphatidylcholine;
from 2%-25% by weight of monoglyceride;
from 2% to 30% by weight of fatty acid ester of C1-C3 alcohol; and
volatile solvent selected from the group consisting of:
ethanol; ethanol and C3-C4 alcohol; ethanol and volatile silicone oil; and ethanol, C3-C4 alcohol and volatile silicone oil.
US Pat. No. 10,363,316

PHARMACEUTICAL FORMULATION COMPRISING NSAID AND CYCLODEXTRIN

RECKITT BENCKISER HEALTHC...

1. A liquid throat spray composition for topical application to a sore throat consisting essentially of an aqueous solution of at least 1% w/v of flurbiprofen, a cyclodextrin, and a pharmaceutically acceptable buffer,wherein the molar ratio of the NSAID to the cyclodextrin is between 1:0.5 and 1:1.5; and
wherein the composition is provided in a unit volume of up to about 2 ml.
US Pat. No. 10,363,572

METHOD FOR PRODUCING A MULTICOAT PAINT SYSTEM ON PLASTICS SUBSTRATES

BASF Coatings GmbH, Muen...

1. A method for producing a paint system on a plastics substrate, the method comprising:(1) producing a basecoat film or a plurality of directly successive basecoat films on the plastics substrate by applying an aqueous basecoat material to the substrate or directly successively applying a plurality of basecoat materials to the substrate;
(2) producing a clearcoat film directly on the basecoat film or a topmost basecoat film by applying a clearcoat material directly to the basecoat film or the topmost basecoat film; and
(3) jointly curing the basecoat film and the clearcoat film or the basecoat films and the clearcoat film,
wherein:
the aqueous basecoat material or at least one of the basecoat materials comprises at least one aqueous polyurethane-polyurea dispersion comprising polyurethane-polyurea particles;
the polyurethane-polyurea particles in the dispersion comprise anionic groups, groups which can be converted into anionic groups, or both;
the polyurethane-polyurea particles comprise, in each case in reacted form:
at least one polyurethane prepolymer containing isocyanate groups and comprising the anionic groups, the groups which can be converted into anionic groups, or both; and
at least one polyamine comprising two primary amino groups and one or two secondary amino groups;
the polyurethane prepolymer does not contain subunits formed from a monoalcohol;
the polyurethane-polyurea particles present in the dispersion have an average particle size of 40 to 2000 nm; and
a gel fraction of the polyurethane-polyurea particles present in the dispersion is at least 50%.
US Pat. No. 10,364,342

TIRE HAVING TREAD FOR LOW TEMPERATURE PERFORMANCE AND WET TRACTION

1. A pneumatic tire having a circumferential rubber tread of a rubber composition comprised of, based on parts by weight per 100 parts by weight elastomer (phr):(A) 100 parts by weight of a combination of conjugated diene-based elastomers comprised of:
(1) about 10 to about 50 phr of an organic solvent polymerization prepared high Tg styrene/butadiene elastomer having a Tg in a range of from about ?40° C. to about ?30° C. with a styrene content in a range of from about 30 to about 35 weight percent wherein said high Tg S-SBR is extended with from about 10 to about 38 parts by weight per 100 parts of said high Tg styrene/butadiene elastomer of triglyceride vegetable oil,
(2) about 10 to about 50 phr of aqueous emulsion polymerization prepared styrene/butadiene elastomer having a Tg in a range of from about ?65° C. to about ?45° C. with a styrene content in a range of from about 15 to about 30 weight percent, and
(3) about 20 to about 60 phr of cis 1,4-polybutadiene rubber having a cis 1,4-isomeric content of at least about 95 percent and having a Tg in a range of from about ?100° C. to about ?108° C.,
(B) about 50 to about 250 phr of rubber reinforcing filler comprised of a combination of precipitated silica derived from silicon dioxide based inorganic sand or from silicon dioxide containing rice husks and rubber reinforcing carbon black where said reinforcing filler is comprised of from about 2 to about 10 phr of said rubber reinforcing carbon black, wherein said precipitated silica of said reinforcing filler is comprised of at least one of:
(1) pre-hydrophobated precipitated silica comprised of precipitated silica pre-hydrophobated with an alkoxyorganomercaptosilane or bis(3-triethoxysilylpropyl) polysulfide containing an average of from about 2 about 4 connecting sulfur atoms in its polysulfidic bridge to form a composite thereof,
(2) precipitated silica having a nitrogen surface area in a range of from about 140 to about 220 m2/g together with a silica coupler having a moiety reactive with hydroxyl groups on said precipitated silica and another different moiety interactive with said diene-based elastomers, and
(3) precipitated silica having a nitrogen surface area in a range of from about 90 to about 130 m2/g together with a silica coupler having a moiety reactive with hydroxyl groups on said precipitated silica and another different moiety interactive with said diene-based elastomers,
(C) about 5 to about 45 phr of traction promoting resin comprised of at least one of terpene, coumarone indene and styrene-alphamethylstyrene resins having a softening point within a range of from about 60° C. to about 150° C.
US Pat. No. 10,363,319

GLYCOCONJUGATES AND METHODS FOR THEIR USE

THE BOARD OF REGENTS OF T...

1. A neoglycoconjugate comprising a trisaccharide coupled to a carrier, wherein the trisaccharide is Gal?(1,3)Gal?(1,4)GlcNAc?.
US Pat. No. 10,364,343

RUBBER COMPOSITION FOR VIBRATION PROOF RUBBERS

TOYO TIRE CORPORATION, I...

1. A rubber composition for vibration proof rubbers, comprising a rubber component comprising one or more diene based rubbers, a multiple zinc flower, sulfur in an amount of 0.05 parts by weight or more and 0.5 parts by weight or less, and a mixed resin, wherein the mixed resin comprises an aromatic hydrocarbon resin and an aliphatic hydrocarbon resin.
US Pat. No. 10,367,160

LIGHT-EMITTING ELEMENT

Semiconductor Energy Labo...

1. A light-emitting element comprising:a light-emitting layer comprising a first compound, a second compound, and a guest material,
wherein the first compound and the second compound are capable of forming an exciplex, and
wherein an emission peak wavelength of the exciplex is longer than or equal to a peak wavelength of an absorption band located on the longest wavelength side of an absorption spectrum of the guest material.
US Pat. No. 10,363,320

CONJUGATE COMPRISING OXYNTOMODULIN AND AN IMMUNOGLOBULIN FRAGMENT, AND USE THEREOF

Hanmi Science Co., Ltd., ...

1. A conjugate comprising:an oxyntomodulin derivative comprising the amino acid sequence of SEQ ID NO: 33;
an immunoglobulin Fc region; and
a non-peptidyl polymer, wherein the non-peptidyl polymer links the oxyntomodulin derivative and the immunoglobulin Fc region via covalent bonds.
US Pat. No. 10,363,322

NON-ALCOHOLIC FATTY LIVER REGULATOR 14-3-3 PROTEIN

Korea University Research...

1. A method of treating non-alcoholic fatty liver, the method comprising administering an inhibitor against a 14-3-3? gene to a subject to decrease transcriptional activity of PPAR?2,wherein the inhibitor comprises an antisense oligonucleotide, siRNA, shRNA or miRNA against the 14-3-3? gene, or a vector comprising the same.
US Pat. No. 10,364,346

ABS-BASED RESIN COMPOSITION AND METHOD ARTICLE MANUFACTURED THEREFROM

LG CHEM, LTD., Seoul (KR...

1. A method of preparing an ABS-based resin composition, the method comprising: a step of feeding (a) 22.5 to 50% by weight of a vinyl cyan compound-conjugated diene-based rubber-like polymer-aromatic vinyl compound copolymer resin, wherein (a) the vinyl cyan compound-conjugated diene-based rubber-like polymer-aromatic vinyl compound copolymer resin is prepared by graft-polymerizing 40 to 70% by weight of a conjugated diene-based rubber-like polymer having an average particle diameter of 2500 to 3500 ? with 8 to 48% by weight of an aromatic vinyl compound and 6 to 24% by weight of a vinyl cyan compound; (b) 47.5 to 75% by weight of an aromatic vinyl compound-vinyl cyan compound copolymer resin; (c) 1 to 6% by weight of a polyether ester amide resin; and (d) 1.5 to 3% by weight of an ethoxylated alkylamine-based antistatic agent into an extruder, followed by mixing and extruding in a 180 to 220° C. barrel.
US Pat. No. 10,364,357

HIGH QUALITY ANTIMICROBIAL PAINT COMPOSITION

THE SHERWIN-WILLIAMS COMP...

1. A paint composition comprising:(a) a binder polymer having a compatibility score of 0.5 or lower;
(b) a quaternary ammonium compound;
(c) at least about 20% by weight titanium dioxide pigment; and
(d) water;
wherein the paint composition has a total solids content of less than 60% by weight and a viscosity of under 120 KU,
wherein the paint composition has a pigment volume concentration (PVC) of about 5 to about 60;
wherein the quaternary ammonium compound is present in a suitable amount to provide one or more of (1) gram negative bacterial reduction by greater than 3 logs within 2 hours of application of the gram negative bacteria to a dried surface of the paint composition; (2) gram positive bacterial reduction by greater than 3 logs within 2 hours of application of the gram positive bacteria to a dried surface of the paint composition; or (3) viral reduction by greater than 3 logs within 2 hours of application of the virus to a dried surface of the paint composition.
US Pat. No. 10,364,361

WEATHERPROOF AQUEOUS WOOD COATINGS

AKZO NOBEL CHEMICALS INTE...

1. An aqueous coating composition comprising:an aqueous solvent,
a fatty amine quaternary having the following structure:
R1R2R3R4N+X?
 wherein R1, R2, R3, and R4 are independently chosen from saturated or unsaturated, linear or branched, substituted or unsubstituted, alkyl, aralkyl, or alkenyl groups, comprising from 1 to 30 carbon atoms, wherein at least one of R1, R2, R3, and R4 includes both a C12-C30 group and ethoxy and/or propoxy groups, wherein X? is an anion from an inorganic or organic acid, and wherein the number average molecular weight of the fatty amine quaternary is between about 100 g/mol and about 1500 g/mol, and
binder in an amount of between 40% to 90% by weight of the aqueous coating composition.
US Pat. No. 10,363,339

WATER ABSORBENT AGENT COMPOSITION AND METHOD FOR PRODUCING SAME, AS WELL AS STORAGE AND STOCKING METHOD FOR SAME

NIPPON SHOKUBAI CO., LTD....

1. A water absorbent agent composition comprising: a polycarboxylic acid (salt)-based water absorbent resin as a main component; a natural ingredient produced by a living organism; and a temporal deterioration preventing agent in an amount of 0.05 ppm to 120 ppm, wherein said temporal deterioration preventing agent is at least one of (a) a water-soluble reducing agent selected from the group consisting of erythorbic acid, L-ascorbic acid, and sulfites, (b) water-soluble oxidants selected from the group consisting of hypochlorous acids and hypochlorites, (c) phenylphenols, (d) benzoic acid or esters thereof, and (e) hydroxybenzoic acid or esters thereof, where the polycarboxylic acid (salt)-based water absorbent resin is a crosslinked polymer of unsaturated monomers, and the unsaturated monomers contain iron (Fe) in an amount of not more than 2 ppm based on the water absorbent agent composition.
US Pat. No. 10,364,365

CURABLE COLORED INKS FOR MAKING COLORED SILICONE HYDROGEL LENSES

Novartis AG, Basel (CH)

1. An ink for making colored silicone hydrogel contact lenses, comprising at least a pigment, a polymeric dispersant, a synergist, a solvent and an actinically or thermally curable silicone-containing binder polymer including ethylenically unsaturated groups and segments derived from at least one silicone-containing vinylic monomer or macromer, wherein the synergist is selected from a group consisting of sulfonated Cu-phthalocyanine, copper phthalocyaninesulfonic acid and combinations thereof, wherein the ink is substantially free of water and has capability to be cured actinically or thermally to form a colored coat on a contact lens, wherein the ink is characterized by having a longer print life using a pad-printing system by at least 30% comparing to the ink which has the same composition except with no polymeric dispersant, wherein ink life is a number of printed parts that can be achieved in a print cycle.
US Pat. No. 10,364,367

NON-NEWTONIAN INKJET INKS

Hewett-Packard Developmen...

1. A non-Newtonian inkjet ink, comprising:a first metal oxide nanoparticle selected from the group consisting of substantially spherical or non-spherical silica particles, alumina particles, zinc oxide particles, iron oxide particles, titanium oxide particles, and combinations thereof, the first metal oxide nanoparticle having a particle size of 10 nm or less, and the first metal oxide nanoparticle present in an amount ranging from about 5% to about 15% by weight based on a total weight of the non-Newtonian inkjet ink;
a second metal oxide nanoparticle selected from the group consisting of alumina, titanium oxide, substantially spherical silica, anisotropic silica, and combinations thereof, the second metal oxide nanoparticle having at least one dimension greater than 10 nm, and the second metal oxide nanoparticle present in an amount ranging from 0.25% to 10% by weight based on the total weight of the non-Newtonian inkjet ink;
a colorant in an amount ranging from about 0.5% to about 10% by weight based on the total weight of the non-Newtonian inkjet ink;
an organic solvent in an amount ranging from about 5% to about 50% by weight based on the total weight of the non-Newtonian inkjet ink; and
a balance of water.
US Pat. No. 10,367,190

CYLINDRICAL SINGLE-PIECE LITHIUM-ION BATTERY OF 400AH AND ITS PREPARATION METHOD

Tianjin University, Tian...

1. A method of making a cylindrical single-piece lithium-ion battery, comprising steps as follows:(1) mixing evenly LiFePO4, conductive carbon black, graphite, polyvinylidene fluoride as adhesive, and N-methylpyrrolidone as solvent in a weight percentage ratio of 42.0-43.0:1.3-1.7:0.8-1.2:2.5-3.5:51.0-53.0 to form a first slurry and mixing evenly lithium titanate, conductive carbon black, graphite, polyvinylidene fluoride as adhesive and N-methylpyrrolidone as solvent in a weight percentage of 49.0-50.0:0.8-1.2:0.8-1.2:3.0-4.0:44.0-46.0 to form a second slurry;
(2) coating and rolling the first slurry and the second slurry to form a positive electrode sheet and a negative electrode sheet, respectively, wherein each of the positive and negative electrode sheets is of a length of 33.81m, has an aluminum foil as current-collector and exposes a foil edge, and the aluminum foil has a thickness between 28 ?m and 32 ?m and a width between 319 mm and 321 mm;
(3) baking the positive electrode sheet and the negative electrode sheet for 48 hours at 100° C.;
(4) aligning and stacking up the positive electrode sheet and the negative electrode sheet with a separating membrane in-between, which are then mounted to an automatic winding machine to form a cylindrical shape;
(5) welding a plurality of aluminium tabs onto the foil edge of the positive electrode sheet and a plurality of aluminium tabs onto the foil edge of the negative electrode sheet, wherein each of the aluminium tabs has a length between 69 mm and 71 mm, a width between 9.9 mm and 10.1 mm and thickness between 0.135 mm and 0.165 mm;
(6) securing each of the aluminium tabs in a space defined by wiring terminal 6 and sliding ring 7 using tab clamping nut 8 to form a cell pack;
(7) inserting the cell pack into an enclosure with two ends each being wrapped by a supporting bracket;
(8) connecting sequentially wiring terminal 6, O-ring 10, insulation cushion 9 and cover 11 together, which are then fixed with clamping nut 12 and locating screw 13; and
(9) sealing cover 11 to the enclosure using a laser welder.
US Pat. No. 10,364,377

ADHESIVE COMPOSITIONS MADE FROM PROPYLENE-BASED POLYMERS AND CRYSTALLINE C2/C3 HOMOPOLYMER

ExxonMobil Chemical Paten...

1. An adhesive composition comprising:a polymer blend comprising a first propylene-based polymer, wherein the first propylene-based polymer is a homopolymer of propylene or a copolymer of propylene and ethylene or a C4 to C10 alpha-olefin, and a second propylene-based polymer, wherein the second propylene-based polymer is a homopolymer of propylene or a copolymer of propylene and ethylene or a C4 to C10 alpha-olefin; wherein the second propylene-based polymer is different than the first propylene-based polymer; wherein the polymer blend has a melt viscosity, measured at 190° C. and determined according to ASTM D-3236, of about 1,000 cP to about 5,000 cP;
a propylene polymer, wherein the propylene polymer is a homopolymer of propylene or a copolymer of propylene units with from about 0.5 to about 4 wt. % ethylene of C4 to C10 alpha-olefin comonomer derived units, and wherein the propylene polymer has a melt flow rate, measured according to ASTM D-1238 at 230° C. and 2.16 kg. of less than about 1,000 g/10 min; and
wherein the adhesive composition is substantially free of a functionalized polyolefin, wherein the functionalized polyolefin is selected from at least one of a maleic anhydride-modified polypropylene and a maleic anhydride-modified polypropylene wax.
US Pat. No. 10,364,378

POLARIZING STRUCTURE COMPRISING A GLYOXAL ADHESIVE SYSTEM AND POLARIZED LENS COMPRISING IT

ESSILOR INTERNATIONAL, C...

1. A polarizing structure comprising:a polarizing film having faces; and
a protective film provided on both faces of the polarizing film with an adhesive layer;
wherein the adhesive layer is a glyoxal-based adhesive obtained from a glyoxal water solution comprising:
about 5% by weight of glyoxal; and
about 5% by weight of polyvinyl alcohol (PVOH) polymer
at least one of the protective films comprises PC or PMMA; and
wherein a first face of the at least one protective film is oriented towards the polarizing film and further comprises an adhesion primer structure.
US Pat. No. 10,367,199

CATHODE ACTIVE MATERIAL, LITHIUM SECONDARY BATTERY HAVING SAME, AND METHOD FOR PREPARING SAME

Korea Electronics Technol...

1. A cathode active material for lithium secondary batteries which is represented by Chemical Formula 1 below and is obtained by coating a dissimilar metal (M) on a surface of a transition metal precursor comprising Ni, Co and Mn and then heat-treating the transition metal precursor together with a lithium source so that a portion of Ni, Co and Mn is substituted with the dissimilar metal (M):LiNiaCobMncMdO2  [Chemical Formula 1 ]
wherein 0.65?a ?0.7, 0
US Pat. No. 10,364,403

MARINE DIESEL CYLINDER LUBRICANT OIL COMPOSITIONS

Chevron Oronite Technolog...

1. A marine diesel cylinder lubricating oil composition which comprises:(a) a major amount of one or more Group I basestocks, and
(b) a detergent composition comprising:
(i) about 5 to about 15 wt. % on an actives basis, based on the total weight of the marine diesel cylinder lubricating oil composition, of one or more alkaline earth metal salts of an alkyl-substituted hydroxyaromatic carboxylic acid having a total base number (TBN) of about 100 to about 250, wherein the alkyl-substituted moiety of the alkaline earth metal salt of an alkyl-substituted hydroxyaromatic carboxylic acid is a C12 to C28 alkyl group; and
(ii) about 5 to about 16 wt. % on an actives basis, based on the total weight of the marine diesel cylinder lubricating oil composition, of one or more high overbased calcium alkyl toluene sulfonic acids or salts thereof having a TBN of greater than 250 to about 550; wherein the toluene moiety of the calcium alkyl toluene sulfonic acids or salts thereof contains no hydroxyl groups, and further wherein the alkyl moiety of the calcium alkyl toluene sulfonic acids or salts thereof is a C12 to C40 alkyl group; and
wherein the marine diesel cylinder lubricating oil composition has a TBN of about 55 to about 80.
US Pat. No. 10,364,415

1,4-DIOXANE-DEGRADING BACTERIA CULTURE METHOD, MEDIUM, AND 1,4-DIOXANE TREATMENT METHOD USING 1,4-DIOXANE-DEGRADING BACTERIA

TAISEI CORPORATION, Toky...

1. A 1,4-dioxane-degrading bacteria culture method comprising culturing/incubating 1,4-dioxane-degrading bacteria with a medium containing diethylene glycol at a concentration of 1.0 wt % or more and 10.0 wt % or less, thereby multiplying the 1,4-dioxane-degrading bacteria, wherein the 1,4-dioxane-degrading bacteria are at least one of Mycobacterium sp. D11 (Accession Number: NITE BP-01926) or Pseudonocardia sp. D17 (Accession Number: NITE BP-01927).
US Pat. No. 10,364,426

PROCESS FOR REDUCING CELL DEATH AND INCREASING GROWTH OF AN ALGAL CULTURE

MISSING LINK TECHNOLOGY, ...

1. A process for reducing cell death and increasing growth of an algal culture, the process comprising:mixing the algal culture with water in a first reactor, the first reactor being a continuously stirred reactor, the step of mixing comprising:
continually circulating nutrients and the algal culture in a toroidal pattern and in a bottom-to-top pattern within said first reactor;
strobing light onto the mixture of algal culture and water for a period of time at a frequency of between 10 Hz and 40 Hz and between twenty flashes per second and eighty flashes per second;
flowing the strobed mixture of the algal culture and water from said first reactor for a period of time to a second reactor, the second reactor being a plug flow reactor, the step of flowing further comprising:
discharging the strobed mixture through a central drain of the first reactor to decrease fluid velocity of the strobed mixture and obtain a Reynolds Number (NRE) of less than 2000 is the second reactor;
discharging the strobed mixture from the second reactor; and
reducing cell death and increasing growth of said algal culture at a growth rate exceeding 120 grams/m2/day.
US Pat. No. 10,364,434

COMPOSITIONS AND METHODS OF BIOSYNTHESIZING CAROTENOIDS AND THEIR DERIVATIVES

ARCH INNOTEK, LLC, St. L...

1. A recombinant microorganism comprising a nucleic acid construct comprising:a) a nucleic acid sequence encoding a lycopene s-cyclase enzyme encoded by LCYe from Lactuca sativa; and
b) a nucleic acid sequence encoding a carotenoid cleavage dioxygenase enzyme encoded by CCD1 from Daucus carota:
wherein the nucleic add sequences are operably linked to one or more expression control sequences, and wherein the microorganism further comprises lycopene.
US Pat. No. 10,364,438

METHODS AND COMPOSITIONS FOR OBTAINING USEFUL PLANT TRAITS

NUTECH VENTURES, Lincoln...

1. A plant or plant cell comprising a mutation in a MutS Homolog 1 (MSH1) gene polynucleotide sequence encoding the FYE amino acid sequence of the DNA binding domain 1 of the MSH1 polypeptide, wherein the mutation encodes the amino acid sequence FYZ in the DNA binding domain 1 wherein Z is any amino acid other than E, wherein such mutation is not present in control plants of the same species, wherein MSH1 function is suppressed in plastids of the plant or plant cell, and wherein MSH1 function is maintained in mitochondria of the plant or plant cell.
US Pat. No. 10,364,187

JAMB SPRAY MIXES INCLUDING FUSED SILICA AND METHODS OF UTILIZING THE MIXES

Resco Products, Inc., Pi...

1. A jamb spray mix comprising:0.1% to 10% phosphate by weight based on total weight of dry ingredients in the mix;
5% to 15% plasticizer based on total weight of dry ingredients in the mix;
the balance of dry ingredients including fused silica particles and impurities; and
at least 20% water by weight based on total weight of the mix.
US Pat. No. 10,364,446

STREPTOMYCES PSAMMOTICUS AND METHODS OF USING THE SAME FOR VANILLIN PRODUCTION

XIAMEN OAMIC BIOTECHNOLOG...

1. A method for producing vanillin using Streptomyces psammoticus strain OMK-4 having preservation number CCTCC M 2015329, wherein the method comprises the steps of:1) strain activation;
2) seed culture; and
3) fermentation of ferulic acid to produce vanillinwherein strain activation step 1 comprises:under aseptic conditions, a full inoculation loop of strain OMK-4 from a glycerin stock tube is spread evenly over an agar slant and cultured in a biochemical incubator at 26-30° C. for 24-48 hours, and wherein by percentage of weight, the agar slant comprises the following components:soluble starch 1.0-3.5%, KH2PO4 0.1-1.0%, NaCl 0.05-0.3% and yeast extract powder 0.1-1.0%, andwherein seed culture step 2 comprises:under aseptic conditions, a full inoculation loop of well-grown OMK-4 cells from the ager slant in step 1 is inoculated into a seed culture medium having an initial pH value of 5-8 and cultured at 28-35° C. with 200-500 rpm shaking until exponential growth phase, wherein the said seed culture medium by weight percentage comprises the following components:soluble starch 1.0-3.5%, KH2PO4 0.1-0.5%, urea 0.1-0.3%, MgSO4 0.05-0.1%, CaCO3 0.1-0.3%, yeast extract powder 0.1-1.0%, corn syrup 0.1-1.0%, (NH4)2SO4 0.1-0.6% and ferulic acid 0.1-0.3%, andwherein fermentation step 3 comprises:the OMK-4 cells from step 2 in exponential growth phase are inoculated into a fermentation medium with the volume ratio of 5-15% under aseptic conditions wherein the initial pH of the fermentation medium is 7.2 to 7.8 at 30-40° C. and 200-500 rpm shaking and 1:0.5 ventilation, to ferment the cells for 70-120 hours, wherein the fermentation medium by weight percentage comprises the following components: soluble starch 2.0-5.0%, KH2PO4 0.1-0.3%, urea 0.1-0.5%, MgSO4 0.05-0.1%, CaCO3 0.5-2.0%, yeast extract powder 0.1-1.0%, (NH4)2SO4 0.1-0.5% and ferulic acid 0.1-3.0%.
US Pat. No. 10,364,447

PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA

Universitat Des Saarlande...

1. A method for the production of omega-3 polyunsaturated fatty acids which comprises:(a) preparing a vegetative inoculum of cells of an Aetherobacter strain that produces one or more omega-3 polyunsaturated fatty acids, wherein the Aetherobacter strain has a 16s rDNA sequence that is at least 97% identical to the 16s rDNA sequence set forth in SEQ ID NO: 1, 2 or 4;
(b) transferring the inoculum of step (a) to an aqueous nutrient medium and culturing the cells of said Aetherobacter strain under submerged aerobic conditions; and
(c) isolating one or more omega-3 polyunsaturated fatty acids from the cells cultured in step (b), wherein isolating comprises the steps of drying the cells, extracting the dried cells and purifying the one or more omega-3 polyunsaturated fatty acids.
US Pat. No. 10,364,458

ISOTHERMAL METHODS FOR AMPLIFYING NUCLEIC ACID SAMPLES

Tangen Biosciences, Inc.,...

1. A two-stage nucleic acid amplification and real-time detection method comprising a providing a composition comprising a target nucleic acid template and at least one primer that anneals to the target nucleic acid template near a region of interest to be amplified; b. performing a first nucleic acid amplification reaction to amplify the region of interest, thereby forming a primary amplicon; c. dividing (b) into at least two secondary reactions, and including in at least one of the reactions a site-specific secondary primer that is complementary to a site-specific primer binding site that may be present within the primary amplicon and defines a site of interest within the region of interest; d. performing a second nucleic acid amplification reaction (second-stage reaction) thereby accelerating the amplification of the region of interest only if the site-specific primer binding site is complementary to the site-specific primer; and e. detecting and comparing in real-time the amplification rates of the at least two secondary reactions, wherein an enhanced relative rate of amplification in the reaction with the secondary primer indicates the presence of the site of interest that is complementary to the secondary primer.
US Pat. No. 10,364,203

METHOD FOR PREPARING PHENOLICS USING A CATALYST

1. Method for preparing a phenolic compound comprising reacting a furanic compound with a dienophile in the presence of a catalyst comprising yttrium.
US Pat. No. 10,364,459

METHOD OF QUANTITATIVELY AND QUALITATIVELY ANALYZING BIOMATERIAL IN REAL-TIME

SUGENTECH, Inc., Daejeon...

1. A method of quantitatively and qualitatively analyzing a biomaterial in real-time, the method comprising:preparing a device for detecting a biomaterial, wherein the device comprises a reaction container comprising an opening at an upper part thereof; and an element part separately connected to the reaction container via the opening, wherein the element part comprises a cap coupled to the opening of the reaction container; and a rod extended from a lower part of the cap, wherein the rod comprises a biochip having a third probe fixed to a surface of the biochip;
feeding a complex of first and second probes, a forward primer, a reverse primer, a sample comprising deoxynucleotide triphosphate (dNTP), a polymerase having exonuclease activity, and a sample comprising target genes, and a reaction solution comprising a buffer into the reaction container, wherein the first probe comprises oligonucleotide sequences complementary to nucleic acid sequences of the target genes in the sample, a first phosphor for generating a first fluorescence signal, and a first quencher for quenching the first phosphor, the second probe does not comprise oligonucleotide sequences complementary to the nucleic acid sequences of the target genes in the sample, but comprises oligonucleotide sequences complementary to the third probe, and the forward and reverse primers comprise oligonucleotide sequences complementary to the nucleic acid sequences of the target genes to amplify the target genes in the sample;
performing polymerase chain reaction comprising denaturation of the target genes in the sample, hybridization of the target genes, the complex, and the forward and reverse primers in the sample, and elongation of the primers through the polymerase having exonuclease activity, wherein the hybridization is only performed between the target genes and the first probe of the complex, and when the polymerase reaches the complex hybridized with the target genes during the elongation by the polymerase having the exonuclease activity, the second probe and the first phosphor are disassembled and released from the complex hybridized with the target genes by the exonuclease activity of the polymerase, and a first fluorescence signal is generated by the first phosphor;
allowing for DNA microarray in which elongation of the second probe on the third probe by the polymerase after hybridizing the released second probe and the third probe fixed to the biochip are performed, wherein the third probe comprises a second phosphor for generating a second fluorescence signal and a second quencher for quenching the second phosphor, and as the second probe is elongated on the third probe, the secondary structure of the third probe is disassembled, and the second quencher is spaced from the second phosphor, and a second fluorescence signal is generated by the second phosphor; and
detecting a first fluorescence signal by the first phosphor and a second fluorescence signal by the second phosphor.
US Pat. No. 10,364,204

PROCESS FOR MANUFACTURING METHYL TERTIARY-BUTYL ETHER (MTBE) AND OTHER HYDROCARBONS

Lyondell Chemical Techno...

1. A process for manufacturing methyl t-butyl ether (MTBE) comprising:a first step comprising cracking raw material comprising ethane or propane to form ethylene; and recovering residual uncracked raw material;
a second step comprising dimerizing ethylene to form a n-butylene feed stream, wherein the n-butylene feed stream comprises:
(i) about 30 to 50 wt. % of 2-butene, based on the total weight of the feed stream,
(ii) about 25 to 45 wt. % of 1-butene, based on the total weight of the feed stream, and
(iii) a higher molecular weight ethylene oligomer
wherein the dimerizing step is performed at a temperature of about 10-100° C., wherein the dimerizing step takes place in the presence of a dimerization catalyst, wherein the dimerization catalyst comprises a nickel compound and an aluminum compound, and wherein the catalyst has a Ni:Al ratio from 0.9:10 to 1:2.5;
a third step comprising isomerizing the n-butylene feed stream to form an isobutylene stream using a isomerization catalyst at a weight hourly space velocity (WHSV) of 0.2-4 kg feedstock per kg catalyst per hour at a pressure of about 345-3450 kPa and a temperature of about 40-200° C., wherein the isomerization catalyst is an acidic isomerization catalyst;
recovering unconverted n-butylene;
alkylating isobutylene with isobutane at a pressure of at least 600 kPa to form gasoline alkylate;
recovering gasoline alkylate;
isomerizing the higher molecular weight ethylene oligomer; and
recovering the isomerized higher molecular weight ethylene oligomer;
a fourth step comprising oxidizing methane to form methanol;
a fifth step comprising etherifying the isobutylene stream with methanol to form methyl t-butyl ether;
etherifying the higher molecular weight ethylene oligomer contained in the isobutylene stream with methanol to form a higher-molecular-weight-ethylene-oligomer-based methyl ether;
recovering the higher-molecular-weight-ethylene-oligomer-based methyl ether;
etherifying an isomerized higher molecular weight ethylene oligomer contained in the isobutylene stream with methanol to form an isomerized-higher-molecular-weight-ethylene-oligomer-based methyl ether; and
recovering the isomerized-higher-molecular-weight-ethylene-oligomer-based methyl ether; and
a sixth step comprising collecting the methyl t-butyl ether.
US Pat. No. 10,364,466

BIOLOGICAL MARKERS FOR IDENTIFYING PATIENTS FOR TREATMENT WITH VEGF ANTAGONISTS

Genentech, Inc., South S...

1. A method of optimizing therapeutic efficacy of a VEGF antagonist for a patient, the method comprising:(a) detecting expression of at least three genes set forth in Table 2 in a sample obtained from the patient prior to any administration of a VEGF antagonist to the patient;
(b) comparing the expression level of the at least three genes to a reference expression level of the at least three genes, wherein a change in the level of expression of the at least three genes in the patient sample relative to the reference expression level identifies a patient who is likely to respond to treatment with a VEGF antagonist; and
(c) administering a VEGF antagonist to the patient identified in step (b) as likely to respond to treatment with a VEGF antagonist,
wherein the VEGF antagonist is an anti-VEGF antibody and the change in the level of expression of the at least three genes in the patient sample is an increase relative to the reference expression level.
US Pat. No. 10,364,474

MICROBIAL MARKERS AND USES THEREFOR

IMMUNEXPRESS PTY LTD, Bo...

1. A method of treating a sepsis-associated bacterial infection in a mammalian subject, the method comprising:1) determining that a subject has an infection with a sepsis-associated Gram positive or Gram negative bacterium by detecting a single nucleotide polymorphism (SNP) in a 16S rRNA gene in nucleic acid from a blood sample from the subject, wherein the SNP is at a position corresponding to position 396 of the 16S rRNA gene set forth in SEQ ID NO:1, and wherein
the bacterium is determined to be a Gram-negative bacterium only when there is a C at position 396 and the bacterium is determined to be a Gram-positive bacterium only when there is an A, T or G at position 396; wherein the bacterium is selected from among Salmonella enterica, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Enterococcus faecalis, Enterococcus faecium, Clostridium perfringens, Streptococcus anginosus, Streptococcus constellatus, Streptococcus intermedius, Streptococcus mitis, Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus bovis, Streptococcus sanguinis, Streptococcus dysgalactiae, Streptococcus mutans, Streptococcus pyogenes, Escherichia coli, Acinetobacter baumannii, Bacteroides fragilis, Burkholderia cepacia, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Enterobacter aerogenes, Enterobacter cloacae, Serratia marcescens, Proteus mirabilis, Citrobacter freundii, Morganella morganii, Haemophilus influenzae, Neisseria meningitidis, Stenotrophomonas maltophila, Prevotella buccae, Prevotella intermedia, Prevotella melaninogenica, Mycobacterium tuberculosis, Streptomyces somaliensis and Streptomyces anulatus; and
2) administering to the subject a therapy when the subject is determined in step 1) to have an infection with a sepsis-associated Gram positive or Gram negative bacterium, wherein the therapy comprises administration of an antibiotic and/or an antibody to endotoxin.
US Pat. No. 10,366,782

METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS, AND THERAPEUTICS FOR CARDIOVASCULAR DISEASE CONDITIONS

uBiome, Inc., San Franci...

1. A method for at least one of characterizing and treating a cardiovascular condition for a subject, the method comprising:providing a sampling kit to the subject associated with the cardiovascular condition, the sampling kit comprising a sample container and a pre-process reagent component, wherein the sample container is operable to receive a sample;
receiving the sample from the sampling kit, the sample comprising a microorganism component;
selecting a primer set for a nucleic acid sequence set associated with the microorganism component;
with a next generation sequencing platform, determining a set of microorganism nucleic acid sequences based on the sample and the primer set;
generating a microbiome feature dataset for the subject based on the set of microorganism nucleic acid sequences;
generating a characterization of the cardiovascular condition based on the microbiome feature dataset;
determining a therapy for the subject based on the characterization, wherein the therapy is operable to improve a state of the cardiovascular condition; and
providing the therapy to the subject associated with the cardiovascular condition, wherein the therapy is operable to modulate microbiome composition to improve the state of the cardiovascular condition.
US Pat. No. 10,364,478

BAINITE-CONTAINING-TYPE HIGH-STRENGTH HOT-ROLLED STEEL SHEET HAVING EXCELLENT ISOTROPIC WORKABILITY AND MANUFACTURING METHOD THEREOF

NIPPON STEEL CORPORATION,...

1. A bainite-containing high-strength hot-rolled steel sheet, comprising: in mass %,C: greater than 0.07 to 0.2%;
Si: 0.001 to 2.5%:
Mn: 0.01 to 4%;
P: 0.15% or less (not including 0%);
S: 0.03% or less (not including 0%);
N: 0.01% or less (not including 0%);
Al: 0.001 to 2%; and
a balance being composed of Fe and inevitable impurities, wherein an average value of pole densities of the {100}<011> to {223}<110> orientation group represented by respective crystal orientations of {100}<011>, {116}<110>, {114}<110>, {113}<110>, {112}<110>,{335}<110>, and {223}<110> at a sheet thickness center portion being a range of ? to ? in sheet thickness from the surface of the steel sheet is 4.0 or less, and a pole density of the {332}<113>crystal orientation is 4.8 or less, an average crystal grain diameter is 10 ?m or less and a Charpy fracture appearance transition temperature vTrs is ?20° C. or lower, and a microstructure is composed of 35% or less in a structural fraction of pro-eutectoid ferrite and a balance of a low-temperature transformation generating phase.
US Pat. No. 10,363,202

DENTAL MATERIAL INCLUDING PROPYLBARBITURIC ACID POLYMERIZATION CATALYST

SHOFU INC., Kyoto (JP)

1. A dental material comprising a polymerizable monomer, 1-cyclohexyl-5-propylbarbituric acid and trioctylmethylammonium chloride, wherein the polymerizable monomer comprises a (meth)acrylic acid group-containing monomer.
US Pat. No. 10,363,203

METHOD OF USE, AND COMPOSITION OF, FIRST RESPONDER WET WIPES

DIAMOND WIPES INTERNATION...

1. A method for decontaminating a skin surface by use of a wet wipe, wherein the wet wipe has a composition consisting essentially of:water, by wt. %, within a range of 90.00 to 98.00;
propanediol, by wt. %, within a range of 0.10 to 5.00;
a first blend, by wt. %, within a range of 0.001 to 1.00;
a second blend, by wt. %, within a range of 0.10 to 5.00;
polysorbate 20, by wt. %, within a range of 0.10 to 5.00;
a third blend, by wt. %, within a range of 0.001 to 1.00;
trisodium phosphate, by wt. %, within a range of 0.001 to 1.00;
citric acid, by wt. %, within a range of 0.001 to 1.00;
caprylyl glycol, by wt. %, within a range of 0.001 to 1.00;
benzalkonium chloride, by wt. %, within a range of 0.001 to 1.00;
phenoxyethanol, by wt. %, within a range of 0.001 to 1.00;
sodium benzoate, by wt. %, within a range of 0.001 to 1.00; and
potassium sorbate, by wt. %, within a range of 0.001 to 1.00;
wherein the first blend consists of the first group consisting essentially of chamomilla recutita (Matricaria) flower extract, cucumis sativus (cucumber) fruit extract, althaea officinalis root extract and avena sativa (oat) kernel extract;
wherein the second blend consists of the second group consisting essentially of decyl glucoside, polyglyceryl-10 caprylate/caprate, coco glucoside, and glyceryl oleata; and
wherein the third blend consists of tetrasodium glutamate diacetate and sodium hydroxide.
US Pat. No. 10,363,204

ZINC OXIDE WHICH IS COATED WITH SILICON OXIDE, METHOD FOR MANUFACTURING THE SAME, COMPOSITION WHICH INCLUDES THE ZINC OXIDE COATED WITH SILICON OXIDE, AND COSMETIC

SUMITOMO OSAKA CEMENT CO....

1. Zinc oxide which is coated with silicon oxide, whereinthe surfaces of zinc oxide particles are coated with silicon oxide coatings,
the silicon oxide coatings include at least one element selected from the group consisting of Mg, Ca, and Ba,
a total mass percentage of the at least one element included in the silicon oxide coating is greater than a mass percentage of an alkali metal included in the silicon oxide coatings; and
a total mass percentage of the at least one element included in the silicon oxide coating is 0.01 to 1% by mass and wherein said at least one element selected from a group consisting of Mg, Ca, and Ba in the silicon oxide coatings is present in a form of magnesium silicate, calcium silicate or barium silicate.
US Pat. No. 10,366,789

METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR NEUROLOGICAL HEALTH ISSUES

uBiome, Inc., San Franci...

1. A method for characterizing a pernicious anemia condition for a subject, the method comprising:for each sample of an aggregate set of samples comprising at least one sample comprising microorganisms associated with the pernicious anemia condition:
determining a microorganism nucleic acid sequence upon fragmenting nucleic acid material from the sample, and amplifying the fragmented nucleic acid material using a primer; and
determining an alignment of the microorganism nucleic acid sequence to a reference nucleic acid sequence, thereby determining alignments;
generating a microbiome feature dataset based on the alignments;
generating a characterization of the pernicious anemia condition based on the microbiome feature dataset;
determining a therapy for the subject based on the characterization and a subject sample from the subject; and
providing the therapy to the subject, wherein the therapy is operable to modulate microbiome composition to improve a state of the pernicious anemia condition.
US Pat. No. 10,364,485

ALUMINUM ALLOY SHEET THAT EXHIBITS EXCELLENT SURFACE QUALITY AFTER ANODIZING AND METHOD FOR PRODUCING THE SAME

UACJ CORPORATION, Chiyod...

1. An aluminum alloy sheet comprising a 5000 series aluminum alloy sheet containing 1.0-6.0 mass % of Mg, the Mg concentration in a solid-solution state that is present in an outermost surface area of the aluminum alloy sheet varying in a widthwise direction of the aluminum alloy sheet in the form of a band having a width of a least 0.05 mm and a difference in the concentration of Mg between adjacent bands is no more than 0.20 mass %, and an oxide coating provided thereon.
US Pat. No. 10,363,207

ALL-IN-ONE SKIN-BRIGHTENING FORMULATIONS

1. An all-in-one skin treatment formulation comprising a base composition of ingredients of:from 91.78 to 96% by weight of water;
from 0.0001 to 2% by weight of Kojic Acid;
from 0.05 to 0.15% by weight of Niacinamide;
from 0.8 to 1.2% by weight of Sodium Hyaluronate;
from 0.008 to 0.012% by weight of Licorice Extract; and
from 0.08 to 0.12% by weight of Tocopherol;
up to 5% by weight of a biomimetic encapsulated whitening peptide, wherein said biomimetic encapsulated whitening peptide component comprises water, butylene glycol, hydrogenated lecithin, sodium oleate, oligopeptide-68, and sodium ethylene diamine-tetraacetic acid (EDTA);
up to 0.01% by weight of Retinol;
from 0 to 1.1% by weight of preservatives;
from 0 to 2.5% of lactic acid;
from 0 to 2.5% of glycolic acid; and
from 0 to 2% by weight of Hydroquinone; wherein said biomimetic encapsulated whitening peptide and said Retinol are both present.
US Pat. No. 10,363,719

MONOAXIALLY ORIENTED MULTILAYER CAST FILM

Borealis AG, Vienna (AT)...

1. A multilayer cast film oriented in machine direction, the multilayer cast film comprises at least three layers A, B and C, whereina) layer A is an outer layer comprising a heterophasic propylene copolymer, wherein the heterophasic propylene copolymer of layer A comprises
a-a) 75 to 95 wt % of a polypropylene matrix (PP-M) with an MFR2 (ISO 1133, 230° C., 2.16 kg) of 0.5 to 30.0 g/10 min being a homopolymer or a copolymer which has a comonomer content of less than 10.0 wt %,
a-b) 5 to 25 wt % of a propylene/alpha-olefin rubber (EPR) with at least 50 wt % propylene having an intrinsic viscosity (IV) of 0.8 to 2.5 dl/g, and
a-c) 0.0001 to 1 wt % of an alpha-nucleating agent (NA);
b) layer B is a core layer comprising a high isotacticity polypropylene homopolymer, wherein the high isotacticity polypropylene homopolymer of layer B is characterized by
(b-i) an isotacticity expressed in mmmm pentads of at least 96 mol %, measured by means of 13 C-NMR,
(b-ii) a decaline soluble content of 2.0 wt % or below, and
(b-iii) polydispersity index (PI) of at least 5.5;
and
c) layer C is a sealing layer comprising a propylene based random copolymer or a propylene based terpolymer, optionally in combination with a heterophasic propylene copolymer, wherein the propylene based random copolymer or terpolymer of layer C comprises
(c-i) 80.0 to 98.0 wt % of propylene,
(c-ii) up to 5.0 wt % of ethylene, and
(c-iii) 1.5 to 20.0 wt % of an alpha-olefin having 4 to 20 carbon atoms,
wherein the sum of (c-i), (c-ii), (c-iii) is 100 wt % and the amount of ethylene (c-ii), if present, is lower than the amount of alpha-olefin (c-iii),
wherein the machine direction oriented multilayer cast film has
(i) a tensile modulus measured according to ISO 527-3 on a 50 ?m film in machine direction of at least 2600 MPa and in transverse direction of at least 1200 MPa,
(ii) a haze value measured according to ASTM D1003 on a 50 ?m film of at most 5.5%, and
(iii) a shrinkage measured according to the method as described in the experimental parton a 50 ?m film after 10 minutes at 100° C. in machine direction of at most ?3.0%.
US Pat. No. 10,364,231

METHOD FOR PRODUCING 2,3,5-TRIMETHYL BENZOQUINONE BY OXIDATION OF 2,3,6-TRIMETHYLPHENOL

BASF SE, (DE)

1. A mixture consisting essentially of 2,3,5-trimethylbenzoquinone, the mixture being prepared by a process consisting essentially of the following step:(i) oxidizing 2,3,6-trimethylphenol to 2,3,5-trimethylbenzoquinone with oxygen or an oxygen-containing gas in a two-phase or multiphase reaction medium in the presence of a catalyst or catalyst system at least comprising a copper(II) halide, to give a mixture comprising 2,3,5-trimethylbenzoquinone,wherein the reaction medium comprises water and at least one secondary aliphatic acyclic alcohol having 6 or more carbon atoms.
US Pat. No. 10,363,211

HAIR CONDITIONING COMPOSITIONS COMPRISING LOW VISCOSITY EMULSIFIED SILICONE POLYMERS

The Procter and Gamble Co...

1. A hair conditioning composition comprising:a) a silicone polymer comprising:
i. one or more quaternary groups;
ii. at least one silicone block comprising greater than 200 siloxane units;
iii. at least one polyalkylene oxide structural unit; and
iv. at least one terminal ester group;
wherein said silicone polymer has a viscosity of 500 mPa·s to 100,000 mPa·s at 20° C. at 100% concentration of said silicone polymer with no additional solvents and a shear rate of 0.1 s?1,
wherein said silicone polymer is added to create a pre-emulsified dispersion with a particle size of less than about 1 micron, and
b) a gel matrix comprising:
i. a cationic surfactant;
ii. a high melting point fatty compound, wherein the high melting point fatty compound has a melting point of about 25° C. or higher; and
iii. an aqueous carrier;
wherein said silicone polymer is mixed with said gel matrix.
US Pat. No. 10,363,212

AESCULUS HIPPOCASTANUM EXTRACT

1. A method of improving an appearance of a skin and/or a mucosa, to improve cutaneous strength and/or elasticity, to treat or prevent skin aging, wrinkles, or skin slackening, the method comprising:administering an extract for a cosmetic treatment of the skin and/or mucosa,
said extract being an Aesculus hippocastanum extract obtained by an extraction method comprising:
a solid/liquid extraction step of a flower of Aesculus hippocastanum with a solvent, followed by
a second solid/liquid separation step, and
a third step for recovering the liquid phase,
wherein the solvent consists of a mixture of fructose and glycerin and water.
US Pat. No. 10,365,262

METHOD OF MONITORING A PARAMETER OF A HYDROCARBON WELL, PIPELINE OR FORMATION

Johnson Matthey Public Li...

1. A method of monitoring a parameter of a hydrocarbon well, pipeline or formation, the method comprising:introducing a tracer into the hydrocarbon well, pipeline or formation;
producing a fluid from the hydrocarbon well, pipeline or formation; and
analysing the fluid to determine if the tracer is present in the fluid;
wherein the tracer comprises a halogenated alkoxylated-benzoic acid, an alkoxylated benzene sulfonic acid, a salt of a halogenated alkoxylated-benzoic acid, or a salt of an alkoxylated benzene sulfonic acid.
US Pat. No. 10,363,217

NANO-LIPOSOME CARRIER COMPOSITION CONTAINING HYBRID OF CAS9 PROTEIN AND GUIDE RNA

Moogene Medi Co., Ltd., ...

19. A method for producing a nano-liposome carrier composition, the method comprising:mixing a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) protein and a guide RNA that specifically binds to a target DNA of a human dipeptidyl peptidase-4 (DPP4) gene to produce a hybrid CRISPR complex;
mixing a lecithin, a metal chelating lipid, and a cholesterol in chloroform to produce a lipid film composition;
mixing the hybrid CRISPR complex with the lipid film composition to produce a lipid/CRISPR mixture and applying ultrasonic waves to the lipid/CRISPR mixture;
freezing and thawing the lipid/CRISPR mixture;
re-applying ultrasonic waves to the lipid/CRISPR mixture for a time sufficient to form nano-liposomes encapsulating the hybrid CRISPR complex; and
centrifuging the lipid/CRISPR mixture for a time sufficient to precipitate nano-liposomes encapsulating the hybrid CRISPR complex; and
collecting precipitated nano-liposomes encapsulating the hybrid CRISPR complex.
US Pat. No. 10,363,218

SYNTHESIS OF PROBIOTIC NANOPARTICLES

King Saud University, Ri...

1. An method of fabricating a probiotic nanoparticle, comprising:(a) dissolving a probiotic in methanol to form a first solution;
(b) spraying the first solution into boiling water at a controlled flow rate under ultrasonic conditions to form a sonicated solution; and
(c) stirring the sonicated solution to provide the probiotic nanoparticle.
US Pat. No. 10,363,221

MANUFACTURING SOLID PHARMACEUTICAL DOSAGE FORMS WITH VISIBLE MICRO- AND NANOSTRUCTURED SURFACES AND MICRO- AND NANOSTRUCTURED PHARMACEUTICAL DOSAGE FORM

I-Property Holding Corp.,...

1. A method of forming a pharmaceutical dosage form comprising:impressing, on at least one of a surface and an interface of the dosage form, an area with at least one micro- and/or nanostructure;
the dosage form comprising a quantity and distribution of ingredients so as to enhance an optical contrast effect caused by the impressed micro and/or nanostructure, so that the micro- and/or nanostructure is observable by the human eye,
wherein the impressing is defined by only direct compression of a mixture of selected ingredients with a punching tool to create the solid pharmaceutical dosage form, with the direct compression performed at room temperature without heating and without modifying the physical nature of the material in the mixture, the punching tool having a micro and/or nano-structured surface formed in a tool surface geometry, and wherein particles of the mixture of selected ingredients are sized such that at least some of the particles are reconfigured or deformed by the compressing, these particles thereby taking the shape of the micro and/or nano-structured surface of the punching tool.
US Pat. No. 10,364,246

SMALL MOLECULE INHIBITORS OF THE JAK FAMILY OF KINASES

Janssen Pharmaceutica NV,...

1. A compound selected from the group consisting of2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-(2-hydroxy-2-methylpropyl)acetamide;
2-((1r,4r)-4-(2-(1H-Imidazol-4-yl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile;
2-(1-((1r,4r)-4-(Cyanomethyl)cyclohexyl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-N-((1-hydroxycyclopropyl)methyl)acetamide; and
pharmaceutically acceptable salts, and combinations thereof.
US Pat. No. 10,363,223

DELAYED-RELEASE ENCAPSULATION OF DEER VELVET POWDER TO PROTECT THE DEER VELVET POWDER UNTIL MICELLIZATION AND ABSORPTION WITHIN THE TERMINAL ILLIUM

1. A capsule of deer velvet powder for ensuring delivery of unaltered molecules of the deer velvet powder systemically to organs of a body, the body having a stomach and a small intestine, the small intestine having a terminal ileum, the capsule of deer velvet powder comprising:a delayed release capsule; and
a quantity of deer velvet powder contained within the delayed release capsule,
the delayed release capsule made using hydroxypropyl methylcellulose, and
the delayed release capsule configured to resist digestive processes in the stomach so as to release the quantity of deer velvet powder substantially along the small intestine, thereby ensuring micellization and absorption of various components of the deer velvet powder along the terminal ileum.
US Pat. No. 10,363,224

EXTENDED-RELEASE TOPIRAMATE CAPSULES

UPSHER-SMITH LABORATORIES...

1. A method of dosing a subject for the treatment of convulsions, the method comprising:administering an extended-release topiramate capsule once daily to the subject, wherein the extended-release topiramate capsule comprises:
a capsule shell comprising a single population of coated particles;
wherein each coated particle comprises a core and a coating thereon;
wherein each particle core comprises a homogeneous mixture comprising topiramate throughout its core; and
wherein the coating comprises one or more release controlling agent(s);
wherein the extended-release topiramate capsule, when given as a single-dose to a healthy human subject, achieves an AUC0-inf of 170 to 210 h??g/mL within a 95% confidence interval, and a Cmax of 2 to 4 ?g/mL within a 95% confidence interval.
US Pat. No. 10,365,272

HIGHLY SENSITIVE IMMUNOASSAY FOR RAPID QUANTIFICATION OF MENINGOCOCCAL CAPSULAR POLYSACCHARIDE ANTIGENS

SERUM INSTITUTE OF INDIA ...

1. A method for quantification of conjugated N. meningitidis serogroup X capsular polysaccharide in a sample using an immunological assay, the method comprising:providing a solid support coated with a capture polyclonal antibody;
providing a sample including N. meningitidis serogroup X capsular polysaccharide-TT conjugate and unconjugated N. meningtitidis serogroup X capsular polysaccharide, wherein the sample is lyophilized and resuspended in phosphate buffer saline having pH 7.2±0.2 comprising KCl at a concentration from 75 mM to 140 mM followed by further dilution or the sample is liquid and directly diluted with phosphate buffer saline having pH 7.2±0.2 comprising KCl at a concentration from 75 mM to 140 mM;
applying the sample to the solid support coated with capture polyclonal antibody;
removing unbound sample;
providing a detection monoclonal antibody;
applying the detection monoclonal antibody to the solid support;
removing unbound detection monoclonal antibody;
applying labeled secondary antibody with a label; and
detecting the label;
wherein the assay does not show any interference due to presence of sucrose and glucose excipients.
US Pat. No. 10,364,251

POLYESTERS FROM ASSYMETRICAL MONOMERS BASED UPON BISANHYDROHEXITOLS

New Jersey Institute of T...

1. An AB monomer comprising bisanhydrohexitol derivatives capable of self-polymerization directly to form a sterioregular or regioregular condensation polymer, wherein the AB monomer has the structure:A—X—C—Y—B
wherein:
a. A is a carboxylic acid, an ester, or an acid chloride,
b. Y is a bisanhydrohexitol unit derived from isosorbide, isoidide or isomannide;
c. X is selected from the group consisting of:
i. aromatic rings, including 1,4-phenylene, 1,3-phenylene, 2,6-naphthalene, 2,7-naphthalene or substituted derivatives thereof;
ii. substituted or unsubstituted heterocycles, and
iii. saturated or unsaturated aliphatic chains;
d. B is —OH; and
e. C is an ester carbonyl link with the carbon attached to X and the oxygen attached to Y, and wherein the AB monomer is at least about 98% pure endo-substituted bisanhydrohexitol derivative or an at least about 98% pure exo-substituted bisanhydrohexitol derivative.
US Pat. No. 10,365,275

IMMUNOLOGICALLY ACTIVE POLYPEPTIDE

Institute of Arthritis Re...

1. A method for treating, reducing severity of, or reducing likelihood of occurrence of either or both of TLR2-mediated sepsis and TLR4-mediated sepsis in a subject, comprising administering to the subject a therapeutically effective amount of an immunomodulatory polypeptide of no more than 31, 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13 or 12 amino acids that comprises the amino acid sequence KSIAYLQMNSLK as set forth in SEQ ID NO:2.
US Pat. No. 10,365,277

METHOD FOR MEASURING HEMAGGLUTININ FROM INFLUENZA VIRUS

DENKA SEIKEN CO., LTD., ...

1. A method for measuring haemagglutinin of an influenza virus by a sandwich immunoassay method, said method comprising:extracting haemagglutinin from a sample containing the influenza virus by adding a cationic or anionic surfactant;
combining the extracted haemagglutinin with at least one lectin immobilized on a solid support and with a labeled anti-haemagglutinin antibody that undergoes antigen-antibody reaction with the haemagglutinin; and
measuring the haemagglutinin by sandwich immunoassay, wherein detection of the presence of haemagglutinin indicates the presence of influenza virus,
wherein the at least one lectin binds the haemagglutinin, but does not bind the anti-haemagglutinin antibody, and wherein the at least one lectin is Datura stramonium lectin, and
wherein the cationic and anionic surfactant is at least one selected from the group consisting of sodium dodecyl sulfate, lithium dodecyl sulfate, hexadecyltrimethylammonium bromide, hecadecyltrimethylammonium chloride and hexadecylpyridinium chloride.
US Pat. No. 10,363,232

COMPOSITIONS AND METHODS FOR TREATING SEVERE PAIN

Infirst Healthcare Limite...

1. A method of treating an individual with an inflammatory pain, the method comprising the step of: administering to the individual in need thereof a pharmaceutical composition, wherein the pharmaceutical composition comprises:a) a propionic acid derivative non-steroidal anti-pain drug (NSAID), or a pharmaceutically acceptable salt, solvate, or solvate of a salt thereof, in an amount of about 15% to about 30% of the total weight of the composition; and
b) a pharmaceutically-acceptable lipid in an amount of at least 50% of the total weight of the composition, the pharmaceutically-acceptable lipid comprising a pharmaceutically-acceptable triglyceride in an amount of at least 30% of the total weight of the composition, and a pharmaceutically-acceptable glyceride mixture including a monoglyceride, the pharmaceutically-acceptable glyceride mixture in an amount of at least 20% of the total weight of the composition,
wherein the pharmaceutical composition is formulated to be a solid at a temperature of about 15° C. or lower and have a melting point temperature of about 25° C. or higher.
US Pat. No. 10,365,280

COMPOSITIONS AND METHODS FOR TREATING MALIGNANCIES

DANA-FARBER CANCER INSTIT...

1. A method for identifying a therapeutic agent for treating multiple myeloma (MM), the method comprising:(a) providing a first polypeptide comprising a CD147 polypeptide and a second polypeptide comprising an extracellular cyclophilin A (eCyPA) polypeptide sequence under conditions that allow for binding of the CD147 polypeptide and the eCyPA sequence;
(b) contacting the complex with a test agent;
(c) determining whether the test agent disrupts binding of the first and second polypeptide,wherein disruption of the binding of the first polypeptide and second polypeptide by the test agent indicates the test agent is a putative therapeutic agent for treating MM;(d) contacting the putative therapeutic agent with a multiple myeloma (MM) cell population expressing CD147; and
(e) determining whether the putative therapeutic agent inhibits migration of MM cells from the MM cell population into bone marrow,
wherein inhibition of MM cell migration indicates the test agent is a therapeutic agent for treating MM.
US Pat. No. 10,363,233

GRANULAR FEED SUPPLEMENT

14. A method of supplementing the diet of a ruminant with lysine, the method comprising:providing the ruminant with a ruminant feed composition comprising:
a granulated core comprising lysine sulfate; and
a coating material of two or more layers surrounding the core, the coating material comprising;
oleic acid,
stearic acid, and
palmitic acid;
wherein the total amount of stearic and palmitic acids is at least 90 wt % of the total weight of the coating,
wherein the lysine exhibits a rumen bypass rate greater than 75%, and an intestinal digestibility rate greater than 70%, and
wherein the weight % ratio of core material to coating material is from 50:50 to 70:30.
US Pat. No. 10,365,281

BIOMARKERS OF RAPID PROGRESSION IN ADVANCED NON-SMALL CELL LUNG CANCER

Rush University Medical C...

1. A method for measuring a panel of biomarkers in a subject suspected of having rapidly progressing lung cancer the method comprising:obtaining a biological sample from the subject;
determining whether the subject is treatment naïve or has received at least one treatment;
assaying a level of each biomarker in a first biomarker panel or a second biomarker panel in the biological sample, the first biomarker panel comprising sTNFRI, sTNFRII, CA 19-9, Follistatin, Total PSA, TNF-? and IL-6 for treatment naïve subjects and the second biomarker panel comprising TRAIL, sTNFRI, IGFBP-1, sEGFR, IGF-1, TGF-?, HGF, MMP-7, MMP-2, ?-fetoprotein, Osteopontin, sVEGFR2 and IL-6 for subjects having received at least one treatment.
US Pat. No. 10,365,282

METHOD AND BIOMARKER FOR DETECTING METASTASIS OF SARCOMA

SHANGHAI KEXIN BIOTECH CO...

1. A method for diagnosing a subject suspect of having sarcoma metastasis, the method comprising:obtaining a biological sample of the subject, wherein the biological sample is serum or plasma;
detecting a level of a N-terminal segment of moesin in the biological sample;
comparing the level of the N-terminal segment of moesin detected in the biological sample of the subject to a reference level of the N-terminal segment of moesin detected from a reference sample; and
administering to the subject a treatment for metastasis of a sarcoma when the level of the N-terminal segment of moesin detected in the biological sample is higher than the reference level.
US Pat. No. 10,363,235

COMPOSITIONS COMPRISING 15-HEPE AND METHODS OF TREATING OR PREVENTING FIBROSIS USING SAME

Afimmune Limited, (IE)

1. A method of reducing or preventing fibrosis in a subject in need thereof, the method comprising;identifying the subject as having or as having an increased risk for developing fibrosis associated with an organ or tissue selected from the group consisting of: liver, heart, mediastinum, bone marrow, retroperitoneaum, skin, intestine, joint, and a reproductive organ, or a combination thereof; and, based on the identification,
administering to the subject a composition comprising 15-HEPE wherein the 15-HEPE represents at least 80% by weight of all fatty acids in the pharmaceutical composition.
US Pat. No. 10,364,515

HIGH MODULUS NYLON 6.6 CORDS

KORDSA TEKNIK TEKSTIL ANO...

1. A two or three-ply dipped and heat-set polyamide 6.6 cord comprising: a plurality of polyamide 6.6 raw yarns;wherein the plurality of polyamide 6.6 raw yarns have a tensile stress value greater than 1.30 cN/dtex;
wherein a stress value at 4% elongation of the polyamide 6.6 cord is higher than 1.2 cN/dtex and less than 2.0 cN/dtex,
wherein a heat shrinkage of the polyamide 6.6 cord is higher than 4.0% and less than 7.0% determined at 177° C. under 0.045 g/dtex pretension with 2 minutes exposure time;
wherein the tensile stress value is determined with a tensile tester according to ASTM D885-16.
US Pat. No. 10,365,283

ACTIVATED HER3 AS A MARKER FOR PREDICTING THERAPEUTIC EFFICACY

Daiichi Sankyo Europe Gmb...

1. A method for treating patients responsive to a target specific therapy comprising an inhibitory anti-HER3 antibody, comprising(a) obtaining at least one sample from a subject having a tumor disease, prior to treatment with an inhibitory anti-HER3 antibody, wherein the sample is a normal hair follicle biopsy,
(b) obtaining at least one sample from said subject having said tumor disease after treatment with the inhibitory anti-HER3 antibody, wherein the sample is a normal hair follicle biopsy,
(c) examining the phosphorylation level of a HER3 receptor in said samples,
(d) determining that the phosphorylation level of the HER3 receptor is reduced after treatment with the inhibitory anti-HER3 antibody as compared to the phosphorylation level of the HER3 receptor before treatment with the inhibitory anti-HER3 antibody, and
(e) administering to the subject with said tumor disease, who has been determined in step (d) to have a reduced phosphorylation level of the HER3 receptor, a therapeutically effective amount of said inhibitory anti-HER3 antibody,
wherein the tumor disease is selected from the group consisting of NSCLC, breast, colon, gastric, pancreas and prostate cancer, and
wherein said inhibitory anti-HER3 antibody is selected from the group consisting of antibody U3-1287, 105.5, SGP-1, H3 90.6, 1B4C3, and 2D1 D12.
US Pat. No. 10,363,236

ISOTHIOCYANATE FUNCTIONAL SURFACTANTS, FORMULATIONS INCORPORATING THE SAME, AND ASSOCIATED METHODS OF USE

The William M. Yarbrough ...

1. A surfactant formulation, comprising:a lysine derivative, wherein the lysine derivative comprises an ?-nitrogen and a ?-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least 8 carbon atoms is bound to the ?-nitrogen, and further wherein the ?-nitrogen forms part of an isothiocyanate functional group.
US Pat. No. 10,364,260

PROCESS FOR PREPARING TRIS[3-(ALKOXYSILYL)PROPYL] ISOCYANURATES

Evonik Degussa GmbH, Ess...

1. A process for preparing at least one tris[3-(alkoxysilyl)propyl] isocyanurate selected from the group consisting of tris[3-(trialkoxysilyl)propyl] isocyanurate, tris[3-(alkyldialkoxysilyl)propyl] isocyanurate and tris[3-(dialkylalkoxysilyl)propyl] isocyanurate by hydrosilylation, the process comprising:(A) initially charging a mixture comprising at least one H-silane selected from the group consisting of hydrotrialkoxysilane, hydroalkyldialkoxysilane, and hydrodialkylalkoxysilane, with at least one carboxylic acid and a Pt catalyst, and heating the mixture to a temperature of 50 to 140° C.,
(B) adding a mixture of 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione and at least one alcohol to the mixture obtained in (A) while mixing,
(C) leaving the mixture obtained in (B) to react while mixing and
(D) working up the product mixture thus obtained.
US Pat. No. 10,364,262

METHOD FOR THE SYNTHESIS OF N-PHOSPHONOMETHYLIMINODIACETIC ACID

Monsanto Technology LLC, ...

1. A method for synthesis of N-phosphonomethyliminodiacetic acid or derivatives thereof selected from the group consisting of phosphonate esters of N-phosphonomethyliminodiacetic acid, carboxylate esters of N-phosphonomethyliminodiacetic acid, phosphonate and carboxylate esters of N-phosphonomethyliminodiacetic acid, N-phosphonomethyliminodiacetic acid salts, phosphonate esters of N-phosphonomethyliminodiacetic acid salts, carboxylate esters of N-phosphonomethyliminodiacetic acid salts and phosphonate-carboxylate esters of N-phosphonomethyliminodiacetic acid salts, wherein a cation of the salt is selected from the group consisting of ammonium, isopropylammonium, ethanolammonium, dimethylammonium, trimethylsulfonium, sodium and potassium,comprising the steps of:
a) forming an anhydrous reaction mixture comprising an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties, to form a compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2), wherein in the compound of the formula R1—CH2—NX—CH2—R2:
X is —CH2—COOH and R1 and R2 are each independently nitrile or C1-C4 alkyl carboxylate, or R1 and R2 are both carbonyl groups linked by means of a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; or
X is —CH2—OH and R1 and R2 are each independently nitrile, C1-C4 carboxylate, or carboxylic acid, or R1 and R2 are both carbonyl groups linked by means of a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom;
and wherein in the compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2), R3 is H, an alkyl group; and
the P—O—P anhydride moieties comprising compound is a compound wherein at least one of the one or more P—O—P anhydride moieties comprises one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V) and is selected from the group consisting of tetraphosphorus hexaoxide, P4O7, P4O8, P4O9, pyrophosphites of general formula (RO)2P—O—P(OR)2 wherein R is an alkyl or aryl group, and combinations thereof, and
b) hydrolyzing the compound having the general formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) to form N-phosphonomethyliminodiacetic acid or one of its derivatives.
US Pat. No. 10,365,288

CITRULLINATED BRAIN AND NEUROLOGICAL PROTEINS AS BIOMARKERS OF BRAIN INJURY OR NEURODEGENERATION

THE JOHNS HOPKINS UNIVERS...

1. A method for detecting citrullinated brain injury biomarker proteins in a sample from a subject having or suspected of having brain injury, the method comprising:detecting in the subject's sample citrullinated arginine residues in citrullinated brain injury biomarker protein glial fibrillary acidic protein (GFAP) and/or citrullinated brain injury biomarker protein myelin basic protein (MBP) by detecting the citrullinated arginine residues in said citrullinated biomarker proteins using a detection method selected from mass spectrometry, immunoassay, electrochemical luminescent assay, electrochemical voltametry, electrochemical amperometry, atomic force microscopy, radio frequency multipolar resonance spectroscopy, confocal microscopy, non-confocal microscopy, fluorescence optical detection, luminescence optical detection, chemiluminescence optical detection, absorbance optical detection, reflectance optical detection, transmittance optical detection, birefringence optical detection, refractive index detection, surface plasmon resonance, ellipsometry, resonant mirror detection, grating coupler waveguide detection, or interferometry; thereby detecting citrullinated brain injury biomarker proteins in the subject's sample.
US Pat. No. 10,364,265

ANHYDROSUGAR SYNTHESIS

William Marsh Rice Univer...

1. A method of making an anhydrosugar, comprising:a) dissolving a carbohydrate substrate in a solvent;
b) performing a Fischer glycosidation on the C1 carbon of said carbohydrate substrate by reacting said dissolved sugar substrate with an alcohol in the presence of a solid acid catalyst, wherein said Fischer glycosidation adds the alcohol on said C1 carbon as an ether;
c) removing said solid acid catalyst and said solvent to form a solid sample; and,
d) performing heat treatment on said solid sample to produce a desired anhydrosugar.
US Pat. No. 10,363,242

METHODS OF INHIBITING CATARACTS AND PRESBYOPIA

UNIVERSITY OF MASSACHUSET...

1. An ophthalmic composition comprisingat least one ?-crystallin charge masking agent, wherein the at least one ?-crystallin charge masking agent is a bifunctional molecule consisting of
two different end groups selected from NH2, methyl, a succinimide, a carboxylic acid, isocyanate, an isothiocyanate, a sulfonyl chloride, an aldehyde, a carbodiimide, an acyl azide, an anhydride, a fluorobenzene, a carbonate, an N-hydroxysuccinimide ester, an imidoester, an epoxide and a fluorophenyl ester,
covalently linked to a molecular bristle that is a polyethylene glycol having 4 to 200 oxyethylene groups, an alkoxy-polyethylene glycol having 4 to 200 alkoxyethylene groups, an aryloxypolyethylene glycol having 4 to 200 aryloxyethylene groups, poly(2-hydroxypropyl)methacrylamide (HPMA), poly(2-hydroxyethyl)methacrylate (HEMA), a poly(2-oxaziline), poly(m-phosphocholine, poly lysine, or poly glutamic acid, the molecular bristle having a number average molecular weight of 150 to 8000, and
an ophthalmically acceptable excipient.
US Pat. No. 10,364,268

ION EXCHANGE MEMBRANE CHROMATOGRAPHY

Genentech, Inc., South S...

1. A method of enhancing efficiency of downstream chromatography steps for purification of antibodies consisting of:a. passing a harvested cell culture fluid composition comprising an antibody of interest and various contaminants through a cation exchange membrane, wherein the antibody and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH of about 1 to about 5 pH units below the pl of the antibody and a conductivity of ?about 40 mS/cm, which cause the membrane to bind the antibody and at least one ionic polymer contaminant, where in the ionic polymer contaminant is one or more of polyethyleneimine (PEI), polyvinylamine, polyarginine, polyvinylsulfonic acid, or polyacrylic acid;
b. overloading the cation exchange membrane to promote competitive adsorption such that at least one ionic polymer contaminant remains bound to the membrane while the antibody of interest is primarily in the effluent;
c. collecting the effluent from the cation exchange membrane comprising the antibody of interest;
d. subjecting the membrane effluent comprising the antibody of interest to a cation exchange chromatography purification step, wherein the dynamic binding capacity of the cation exchange chromatography purification step is significantly improved as a result of steps (a) through (c);
e. recovering the purified antibody from the effluent of the cation exchange chromatography purification step;
f. subjecting the cation exchange chromatography purified pool to a final polishing step; and
g. recovering the purified antibody of interest.
US Pat. No. 10,363,246

METHODS AND COMPOSITIONS FOR TREATMENT OF EPILEPTIC DISORDERS

Ovid Therapeutics Inc., ...

1. A method of treating essential tremor comprising administering to a patient in need thereof a pharmaceutical composition comprising gaboxadol or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,364,273

CYTOMEGALOVIRUS ANTIGENS

GLAXOSMITHKLINE BIOLOGICA...

1. A recombinant cytomegalovirus (CMV) gB protein, or an immunogenic fragment thereof, wherein(i) said gB protein, or immunogenic fragment thereof, does not comprise a transmembrane (TM) domain;
(ii) said gB protein, or immunogenic fragment thereof, comprises a hydrophobic surface 1 that corresponds to amino acid residues 154-160 and 236-243 of SEQ ID NO: 1 which comprises a mutation that results in a glycosylation site within said hydrophobic surface 1, but wherein the mutation is not a substitution of one amino acid in fusion loop 1 (FL1) which corresponds to amino acid residues 155-157 of SEQ ID NO: 1.
US Pat. No. 10,364,274

EXPRESSION OF CHIMERIC KSAC PROTEIN AND METHOD OF PRODUCING SOLUBLE PROTEINS BY HIGH PRESSURE

BOEHRINGER INGELHEIM ANIM...

1. A composition comprising (i) a refolded and solubilized fusion protein and (ii) dithiothreitol (DTT), wherein the fusion protein consists of leishmania antigens Kinetoplastid Membrane Protein 11 (KMP11), Sterol MethylTransferase (SMT), A2 and Cysteine Proteinase (CP), and wherein the fusion protein comprises the sequence as set forth in SEQ ID NO:2.
US Pat. No. 10,365,555

MASK BLANK, TRANSFER MASK AND METHODS OF MANUFACTURING THE SAME

HOYA CORPORATION, Tokyo ...

1. A mask blank comprising a light-semitransmissive film and a light-shielding film on a main surface of a transparent substrate, wherein:the light-semitransmissive film is made of a material that is capable of being dry-etched with an etching gas containing a fluorine-based gas,
the light-shielding film, except for a surface layer thereof, is made of a material that consists of tantalum, one or more elements selected from hafnium and zirconium, and one or more elements selected from nitrogen, carbon, hydrogen, boron and inert gases,
the surface layer of the light-shielding film is made of a material that consists of tantalum, oxygen, one or more elements selected from hafnium and zirconium, and one or more elements selected from nitrogen, carbon, hydrogen, boron and inert gases,
a ratio, given in percent, obtained by dividing the total content [at %] of hafnium and zirconium in the light-shielding film by the total content [at %] of tantalum, hafnium and zirconium in the light-shielding film is 10% or more and 50% or less,
an etching stopper film is provided between the light-semitransmissive film and the light-shielding film, and
the etching stopper film is made of a material that contains chromium and has an oxygen content of 20 at % or less.
US Pat. No. 10,365,556

MASK BLANK, PHASE SHIFT MASK, METHOD FOR MANUFACTURING PHASE SHIFT MASK, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

HOYA CORPORATION, Shinju...

1. A mask blank, comprising a phase shift film on a transparent substrate,the phase shift film having a function of transmitting exposure light of an ArF excimer laser with a transmittance of 2% or more, and a function of generating a phase difference of 150 degrees or more between the exposure light that has been transmitted through the phase shift film and the exposure light that has passed through air by a distance that is the same as a thickness of the phase shift film,
the phase shift film having a structure in which a silicon layer and a phase shift layer are laminated in the stated order from the substrate side,
the phase shift layer being formed, except for a surface layer portion thereof, of a material made of silicon and nitrogen, or a material containing, in addition to the material made of silicon and nitrogen, one or more elements selected from non-metallic elements other than oxygen, and metalloid elements,
the phase shift layer having a thickness that is larger than that of the silicon layer,
wherein the silicon layer has a thickness of 3 nm or more and less than 12 nm.