US Pat. No. 10,391,985

ELECTRIC BRAKE CONTROL APPARATUS

TOYOTA JIDOSHA KABUSHIKI ...

1. An electric brake control apparatus comprising:a first clamping force acquisition unit that is configured to acquire a clamping force, the clamping force being a force generated by moving a piston toward a pad through rotation of a motor in a first rotational direction to press the pad against a rotor;
a lower-limit clamping force acquisition unit that is configured to acquire a lower-limit clamping force, the lower-limit clamping force being a minimum value of the clamping force required to maintain a stopped state of the rotor;
an upper-limit clamping force acquisition unit that is configured to acquire, based on a state of a power supply, an upper-limit clamping force, the upper-limit clamping force being a maximum value of the clamping force that is enough to move the piston away from the pad through a power of the power supply while maintaining the stopped state of the rotor; and
a clamping force control unit that is configured to control the motor such that the clamping force acquired by the first clamping force acquisition unit is confined between the lower-limit clamping force and the upper-limit clamping force.

US Pat. No. 10,391,982

LIGHTED VEHICLE WASH CONVEYOR ASSEMBLY

WashMe Properties, LLC, ...

1. A conveyor assembly for conveying a vehicle through a vehicle wash facility comprising:a pair of opposed sidewalls, with each sidewall topped by a guide rail, each of said guide rails secured to its sidewall and capable of engaging a sidewall of a vehicle tire being conveyed in said conveyor assembly;
at least one of said guide rails further including a protective sheath having an indentation therein and covering at least a portion of said guide rail; and
a strip light received in said indentation of said protective sheath and connected to a controller, said controller sending signals to said strip light to switch said strip light between an on mode and an off mode and said controller determining a color emitted by said strip light when said strip light is in said on mode.

US Pat. No. 10,391,981

WASHING APPARATUS FOR A SENSOR ENCLOSURE

Ford Global Technologies,...

1. An apparatus comprising:a sensor enclosure;
a wiper assembly, including a wiper blade;
a guideway wherein said guideway includes a first track below said sensor enclosure and a second track above said sensor enclosure; and
a control module configured to displace said wiper blade between a stowed position free of said sensor enclosure and a deployed position engaging said sensor enclosure, said control module including a controller and an actuator controlled by said controller.

US Pat. No. 10,391,978

WIPER DEVICE FOR MOTOR VEHICLES

1. A wiper device comprising:a driving arm configured to transmit a wiping movement and having a longitudinal end;
a windscreen wiper; and
a fixing device disposed between the longitudinal end of the arm and the windscreen wiper,
wherein the windscreen wiper is equipped with at least one electrical element,
wherein the longitudinal end of the driving arm is equipped with a sending coil and the windscreen wiper is equipped, at a level of the fixing device, with a receiving coil, the cooperation of the sending coil with the receiving coil, when making a mechanical connection between the driving arm and the windscreen wiper, enabling supply of power to said electrical element by magnetic induction between the coils.

US Pat. No. 10,391,948

SELECTABLE PITCH CROSSBAR-TO-VEHICLE COUPLER

Yakima Products, Inc., L...

1. A rack for carrying, cargo on top of a vehicle, the rack comprising:an aerodynamically shaped crossbar having a long axis and an elongate cross-sectional shape perpendicular to the long axis of the crossbar; and
a coupler configured to mount an end portion of the crossbar on top of a vehicle, the coupler including a crossbar clamp configured to selectively secure the crossbar to the coupler;
a first mating surface of the crossbar clamp being receivable on a second mating surface of the coupler in a plurality of discrete orientations, the first mating surface being adjustable relative to the second mating surface along an arc having a central axis perpendicular to the direction of vehicle travel and parallel to the long axis of the crossbar.

US Pat. No. 10,391,941

VEHICULAR VISUAL RECOGNITION DEVICE

KABUSHIKI KAISHA TOKAI-RI...

1. A vehicular visual recognition device comprising:a support body supported by a vehicle body side;
a pivoting member pivotably supported by the support body;
a drive means having an output shaft supported by the pivoting member and configured so as to be capable of generating a drive force;
a limit gear directly supported in a radial direction only by the pivoting member, and indirectly engaging the output shaft, rotation of the limit gear being limited, and the drive force generated by the drive means being transmitted to the limit gear whereby the pivoting member is pivoted; and
a visual recognition means provided so as to be capable of pivoting integrally with the pivoting member, the visual recognition means assisting visual recognition of an occupant of a vehicle, and the visual recognition means being retracted or deployed by the pivoting member being pivoted.

US Pat. No. 10,391,929

LIGHTED PATH SYSTEM FOR VEHICLE

Ficosa North America Corp...

1. A vehicle illumination system for illuminating a path to a vehicle, comprising:a light mechanism arranged on the vehicle;
at least one antenna configured to detect a unique device of an approaching user; and
at least one controller configured to:
determine a user location based on the detected unique device,
predict the path based at least in part on the user location, and
instruct the light mechanism to illuminate an area along the path.

US Pat. No. 10,391,908

HEADREST

GRAMMER AG, Amberg (DE)

1. A headrest comprising:a head box;
a support rod securing the head box to a vehicle seat and rod having one end;
a bearing receiving the one end and carried on the head box or the vehicle seat;
a latch releasably securing the support rod to the bearing and movable between a latching position and a release position and comprised of at least one notch extending angularly on an outer surface of the support rod and a latch element carried by the bearing and movably mounted so that in the latching position, in the event of a relative rotation between the support rod and the bearing, the latch element is movable out of a starting position into at least one crash position; and
a pivot or guide constraining movement of the latch element to a circular path.

US Pat. No. 10,391,900

VENTILATED VEHICLE SEAT

Faurecia Automotive Seati...

1. An occupant support comprisinga cushion having an outer surface arranged to face an occupant of the occupant support, an inner surface spaced apart from the outer surface, and an intermediate surface located between the outer surface and the inner surface and the cushion formed to define a cooling passage that extends between the outer surface and the intermediate surface,
an air-permeable cushion cover arranged around the outer surface of the cushion, and
a ventilation unit located between the intermediate surface and the inner surface of the cushion, the ventilation unit including a flexible support panel and a piezoelectric fan coupled to the support panel, the piezoelectric fan aligned with the cooling passage and including a deformable membrane and a piezoelectric motor configured to undulate the deformable membrane in response to receiving electric energy so that the ventilation unit provides a flow of air through the cooling passage and air-permeable cushion cover to provide convective cooling to the occupant of the occupant support.

US Pat. No. 10,391,855

AIR CONTROL SYSTEM FOR VEHICLES AND ASSEMBLY METHOD

HBPO GMBH, (DE)

1. A device for controlling an air stream to a radiator device of a vehicle, wherein the air stream is guidable through at least one opening to the radiator device comprising:at least one cover element for at least partially closing the opening in at least a closed position, each of the at least one cover element comprising:
a bearing element extending outward from the cover element from a first end of the cover element, wherein the bearing element has a smaller cross-section than the cover element; and
a carrier for installation and operation of the at least one cover element, the carrier comprising a bearing acceptance disposed to align with the bearing element of a corresponding cover element, the bearing acceptance comprising:
a free space and a restriction, wherein the free space is adjusted to the form of the cover element and the restriction is adjusted to the form of the bearing element, such that the bearing element is introduced into the restriction and the cover element is introduced into the free space when the cover element is in an assembly position and such that the bearing element is supported by the restriction and the cover element is outside of the free space upon movement of the cover element along its longitudinal axis into an operating position.

US Pat. No. 10,391,847

LOCKING DEVICE HAVING A LOCKING HOOK AND A MOVABLE SLIDE

WEBASTO SE, Stockdorf (D...

1. A locking device of a top of a convertible vehicle, comprising a locking support, a locking hook, which can be shifted in a translational and rotational manner so as to be displaced between a release position and a locked position and which is engaged with a locking counterpart when in the locked position, and a driving mechanism for the locking hook, the driving mechanism comprising a driving wheel, which is driven by a driving motor and which drives a slide movable on the locking support, the slide being connected to the locking hook in such a manner that the locking hook undergoes a displacing movement when the slide is moved, wherein a securing pin is arranged on a first component, the securing pin engaging into a corresponding recess of a second component when the locking hook is in the locked position, the second component moving relative to the first component when the locking hook is being displaced, the securing pin thus securing the locking hook against being displaced in the direction of the release position when the locking hook is in the locked position.

US Pat. No. 10,391,846

LIFTGATE HANDLE WITH ADJUSTABLE HEIGHT TO IMPROVE REACH AND CLEARANCE REQUIREMENT

Ford Global Technologies ...

1. An adjustable-length handle assembly for a vehicle, comprising:a retractor carried by a vertically articulating closure panel of a vehicle;
a flexible web disposed to deploy from and retract into the retractor;
a flexible web guide roller including a flexible web brake; and
a gripping portion disposed at a distal end of the flexible web.

US Pat. No. 10,391,840

ADAPTABLE ROOF-MOUNTED AIR CONDITIONING SYSTEM FOR VEHICLES

TRANSARCTIC CANADA, INC.,...

1. An air conditioning system for mounting on a vehicle roof, comprising:a condenser module including a condensing fluid path defined by (i) a condenser inlet for receiving a compressed fluid, (ii) a condenser heat exchanger for condensing the fluid and transferring heat from the fluid, and (iii) a condenser outlet for releasing the condensed fluid;
an evaporator module including:
a base for placement on an outer surface of the roof; the base including a plurality of longitudinal segments articulable relative to each other such that the base is deformable to conform to a curvature of the roof prior to installation of the air conditioning system;
an evaporating fluid path supported by the base and defined by (i) an evaporator inlet receiving the cooled condensed fluid from the condensing fluid path outlet, (ii) an expansion valve for vaporizing the fluid, (iii) an evaporator heat exchanger for transferring heat to the vaporized fluid, and (iv) an evaporator outlet for returning the heated vaporized fluid to the condenser module via a compressor; and
an interchangeable end plate connected to an end of each of the longitudinal segments of the base; the end plate configured to prevent further articulation of the longitudinal segments and maintain the deformable base in a shape that conforms to the curvature of the roof.

US Pat. No. 10,391,836

VEHICLE AIR-CONDITIONING DEVICE

Sanden Holdings Corporati...

1. A vehicle air-conditioning device comprising:a compressor which compresses a refrigerant;
an air flow passage through which air to be supplied to a vehicle interior flows;
a radiator disposed in the air flow passage to let the refrigerant radiate heat;
a heat absorber disposed in the air flow passage to let the refrigerant absorb heat;
an indoor blower which blows air through the air flow passage; and
control means comprising a controller for controlling operations of the compressor and the indoor blower,
the vehicle air-conditioning device heating the air to be supplied to the vehicle interior by heat radiated from the radiator to heat the vehicle interior,
the vehicle air-conditioning device comprising:
heat generating means disposed in the air flow passage to heat the air to be supplied to the vehicle interior,
wherein the control means controls timing to start the compressor, the indoor blower and the heat generating means on a basis of an outdoor air temperature,
wherein in a case of a first low outdoor air temperature environment in which the outdoor air temperature is low, the control means starts the compressor prior to the indoor blower, and
the control means starts the heat generating means simultaneously with the indoor blower, immediately after the start of the indoor blower, or after the start of the indoor blower.

US Pat. No. 10,391,828

AXLE COMPONENT FOR A MOTOR VEHICLE AXLE

BENTELER AUTOMOBILTECHNIK...

1. An axle component for a motor vehicle axle, comprising:an upper wall and a lower wall forming a hollow interior space;
at least one bearing receptacle formed by a pair of opposing rim holes through the upper and lower walls;
each rim hole having a respective collar formed by an edge of the wall and to accommodate a rubber-metal bearing to be received therewithin;
wherein the collars of the rim holes are oriented in a same direction as an insertion direction of the rubber-metal bearing; and
wherein the lower collar is oriented outward with respect to the interior space of the axle component and includes an inclined portion being partially set back into the interior space of the axle component in relation to an outer wall of the axle component.

US Pat. No. 10,391,801

INKJET RECORDING METHOD AND INKJET RECORDING APPARATUS

Canon Kabushiki Kaisha, ...

1. An inkjet recording method comprising:forming an ink image by ejecting ink on an ejection receiving medium by an inkjet head comprising a recording element substrate having an element which generates energy that is utilized for ejecting ink, a pressure chamber which has the element in the inside, and an ejection port which ejects ink, wherein the ink is circulated between the inside of the pressure chamber and the outside of the pressure chamber; and
removing at least a portion of a liquid component from the ink image by bringing a liquid absorbing member into contact with the ink image,
wherein the ink contains 5% by mass or more to 30% by mass or less of a water-soluble organic solvent having a boiling point of 110° C. or more, and
50% by mass or more of the water-soluble organic solvent contained in the ink image and having a boiling point of 110° C. or more is removed from the ink image in the removal of at least a portion of a liquid component from the ink image.

US Pat. No. 10,391,783

METHOD FOR OPERATING AN INKJET PRINTING MACHINE

Heidelberger Druckmaschin...

1. A method for operating an inkjet printing machine, which comprises the steps of:providing a refractometer;
determining a condition of a pigmented ink by performing the further steps of:
measuring a value of a refractive index of the pigmented ink with the refractometer;
determining a sedimentation and/or agglomeration of the pigmented ink based on a deviation of the value of the refractive index from a reference value of the refractive index of the pigmented ink by comparing the value of the refractive index with a stored reference value with a computer;
initiating a corrective measure in the printing machine for reducing the refractive index when the deviation exceeds a selected deviation;
comparing a measured, sedimentation-dependent and/or agglomeration-dependent refractive index with at least one stored type-specific refractive index for determining a type of ink;
starting a print job by applying ink with a print head of the printing machine when the deviation is below an acceptable level.

US Pat. No. 10,391,781

PRINTHEAD THAT EVACUATES AIR FROM A SUPPLY MANIFOLD

Ricoh Company, Ltd., Tok...

1. A printhead comprising:a main body comprising an elongated member made from a rigid material; and
a stack of plates affixed to an interface surface of the main body, wherein the stack of plates forms a row of jetting channels configured to jet droplets of a print fluid;
wherein the main body includes:
an inlet surface that is opposite the interface surface;
a first supply port and a second supply port on the inlet surface configured to connect to a fluid reservoir via hoses to receive the print fluid from the fluid reservoir, wherein the first supply port and the second supply port are separated by a distance along a length of the main body;
a supply manifold configured to provide a fluid path for the print fluid to the row of jetting channels, wherein the supply manifold is formed by:
a manifold duct cut along a length of the interface surface of the main body from a first end to a second end, wherein a length of the manifold duct is at least as long as the row of jetting channels;
a first fluid passage that fluidly couples the first supply port to the first end of the manifold duct; and
a second fluid passage that fluidly couples the second supply port to the second end of the manifold duct;
a cavity that runs the length of the manifold duct; and
a semi-permeable membrane disposed between the cavity and the manifold duct along the length of the manifold duct.

US Pat. No. 10,391,763

INKJET PRINTING SYSTEM AND METHOD FOR PROCESSING SUBSTRATES

MEYER BURGER (NETHERLANDS...

1. An inkjet printing system configured to inkjet patterns of liquid material on substrates that each have a length and a width or, alternatively, a diameter, wherein each substrate includes at least two substrate reference marks that are spaced from each other at a distance which is larger than at least half of the length, the width or the diameter of the substrate, the inkjet printing system including:at least one chuck on which a substrate can be placed, each chuck having a length and a width or, alternatively, a diameter and including at least two visual chuck reference marks that are spaced apart from each other at a distance which is larger than at least half of the length, the width or the diameter of the chuck;
at least one inkjet printing head that includes at least one nozzle that is configured to discharge liquid when the nozzle is fired by a control signal;
a printing motion assembly that supports at least one of the at least one chuck and the at least one inkjet printing head so that a two dimensional printing area on the at least one chuck can be covered with liquid discharged by the at least one printing head; and
an electronic controller assembly configured to produce control signals to fire the at least one nozzle and configured to control the printing motion assembly for positioning the at least one printing head relative to the at least one chuck so that the positioning variation with which the liquid is deposited relative to the chuck is less than a first threshold value,wherein:each reference mark of the at least one chuck is associated with an associated camera that is directed to the associated chuck reference mark, each camera having a two dimensional matrix of camera pixels, each pixel having a pixel coordinate;
each chuck includes a placement area extending within a boundary; and
when a substrate has been placed in or on the placement area of a said chuck, each camera that is associated with a chuck reference mark is also associated with an associated substrate reference mark in that an image taken with a said camera includes an associated chuck reference mark and an associated substrate reference mark, and
the controller assembly is configured:
to control the at least two cameras to take a set of images each instance a substrate has been placed on that chuck, wherein each camera takes a single image of the set of images, wherein each single image of the set of images includes an associated chuck reference mark and an associated substrate reference mark;
to determine, for each set of images, the position of the chuck relative to the at least two cameras by detecting, for each image of the set of images, the position of a said chuck reference mark with respect to the camera pixel coordinates of a said associated camera;
to determine, for each set of images, the position of the substrate relative to the at least two cameras by detecting, for each image of the set of images, the position of a said substrate reference mark with respect to the camera pixel coordinates of a said associated camera; and
to use these two position determinations to calculate, for each set of images, the substrate position relative to the chuck reference marks and thus relative to the chuck with an accuracy of less than a second threshold value and, based on that relative position, subsequently time the firing of the at least one nozzle of the at least one printing head and control the movement of the printing motion assembly so that the liquid discharged by the inkjet printing head is positioned on the substrate with a positioning variation which is less than the sum of the first and the second threshold values.

US Pat. No. 10,391,759

ROTOGRAVURE PRINTING SYSTEM AND THE PREPARATION AND USE THEREOF

Paramount International S...

1. A method of operating a rotogravure printing system comprising a machine provided with at least one rotatable shaft and an end plate for transfer of shaft rotation to a cylinder sleeve,which system further comprises a first rotogravure cylinder sleeve having a first base and a first gravure at a printing surface comprising a first outside layer package deposited over the first base and a second rotogravure cylinder sleeve having a second base and a second gravure at a printing surface comprising a second outside layer package deposited over the second base,
said first base and second base being of the same size while said first printing surface and said second printing surface are of different outside diameter sizes,
each first and second base contains aluminum or aluminum alloy,
each first and second outside layer package comprises at least one high-velocity thermally sprayed copper or copper alloy layer, and each layer of the first layer package and the second layer package has a hardness greater than the base, and
said rotogravure cylinder sleeves are to be rotated by means of the at least one shaft and an end plate coupled thereto,
which method comprises:
(a) assembling the end plate and the first rotogravure cylinder sleeve, which end plate is provided with at least one contact surface that is designed for contact with a mating contact surface defined at an inner side of each of the cylinder sleeves,
(b) mounting the end plate and the first rotogravure cylinder sleeve onto the shaft;
(c) carrying out a first printing operation, comprising the step of rotating the at least one shaft, and therewith the first rotogravure cylinder, so as to print the substrate in accordance with the gravure of the first rotogravure cylinder sleeve, and thereafter,
(d) disassembling the end plate and the first rotogravure cylinder sleeve,
(e) assembling the end plate with the second rotogravure cylinder sleeve, and
(f) carrying out a second printing operation with the gravure of the second rotogravure cylinder sleeve.

US Pat. No. 10,391,728

ROTARY FAN PRESS WITH AUGER

Prime Solution Inc., Ost...

1. A liquid extraction assembly for extracting liquid from a mass comprising:a housing having an inlet and an outlet;
the housing further including a path between the inlet and the outlet;
the housing being configured to have the mass forced into the inlet to move the mass from the inlet to the outlet;
the housing including a pair of rotating screens adjacent the path, the path being defined in an area between the rotating screens;
each of the rotating screens including a plurality of openings located at the path;
wherein pressure from mass forced into the inlet presses the mass against the openings of the rotating screens to thereby force at least a portion of liquid in the mass to pass through the openings of the rotating screens;
the housing having at least one stirring arm extending into the path between the inlet and the outlet, the at least one stirring arm stirring the mass in the path; and
wherein at least a majority of the at least one stirring arm is located in the path between the rotating screens.

US Pat. No. 10,391,721

DEVICE AND METHOD FOR POSITIONING A PLY OF MATERIAL OF A COMPOSITE COMPONENT ALONG AN ARCUATE SURFACE

BOMBARDIER INC., Dorval ...

1. A device for positioning a ply of material of a composite component along an arcuate surface, the ply comprising two end portions and a plurality of fiber tows extending longitudinally between the two end portions, the arcuate surface having a curved edge and a planar surface extending from the curved edge, the device comprising:two curving units, each curving unit being disposed at opposed ends of the arcuate surface and including:
a clamp adapted to clamp an end portion of the ply when a first longitudinal edge portion of the ply is placed along the curved edge; and
a base supporting the clamp, the base being rotatable about a pivot axis normal to the base between a first position and a second position, wherein rotation about the pivot axis is operative to cause:
rotating of the two opposed end portions of the ply, each about the corresponding pivot axis normal to the ply;
sliding of at least some of the plurality of fiber tows relative to each other; and
substantial aligning of the plurality of fiber tows in a curved direction along the arcuate surface.

US Pat. No. 10,391,720

METHOD FOR MAKING A SLIP RESISTANT MAT

Cintas Corporate Services...

1. A method of making a slip resistant mat having a slip resistant pattern on a backing of the mat, the method comprising the steps of:forming a model platen with a replica of the slip resistant pattern;
forming a screen mold with the model platen in which the screen mold has a negative of the slip resistant pattern formed by the replica of the slip resistant pattern; and
forming the slip resistant mat with the screen mold in which the negative of the slip resistant pattern forms the slip resistant pattern on the backing of the mat.

US Pat. No. 10,391,716

ARTICULATING VACUUM PLATE SYSTEM AND RELATED METHOD

Grotown VI, LLC, Grand R...

1. A method of forming a three dimensional article comprising:providing a first vacuum plate and a second vacuum plate arranged in a first mode in which the first vacuum plate and the second vacuum plate are configured to cooperatively form a generally planar, two dimensional surface, each vacuum plate including a plurality of vacuum ports and an internal vacuum chamber, each vacuum chamber of each vacuum plate being separate and independent from the other vacuum chamber, each vacuum plate being in fluid communication with a vacuum source;
loading a film on the first and second vacuum plates with the first and second vacuum plates in the first mode, so that the film is adjacent the two dimensional surface and so that the film is in a generally planar, two dimensional form;
applying a vacuum through the plurality of vacuum ports to draw the film toward the two dimensional surface;
articulating the first and second vacuum plates so that the plates cooperatively transition to a second mode in which the film transitions from the generally planar, two dimensional form to a three dimensional form;
moving the film on the first and second vacuum plates relative to a contoured mold having a three dimensional net shape; and
engaging the film against the contoured mold to configure the film into the three dimensional net shape,
wherein the contoured mold is in the form of a hood disposed adjacent the first and second vacuum plates when in the first mode,
wherein the first and second vacuum plates move into at least a portion of the hood during the moving step.

US Pat. No. 10,391,702

PERSONAL WATERCRAFT FABRICATION USING THERMOFORMING

Free Form Factory, Inc., ...

1. A method of forming a jet-pump powered personal watercraft, the method comprising:producing a top deck mold for a first component of the personal watercraft, the top deck mold including a plurality of features for assimilation into the first component, the plurality of features of the top deck mold including a foot tray feature, a bulkhead/firewall feature, a gunwales feature, an engine bay opening feature, and a first bond rail feature;
inserting a first thermoplastic material into a heater;
draping the heated first thermoplastic material over the top deck mold;
drawing the heated first thermoplastic material into or over the top deck mold using a vacuum, the heated first thermoplastic material assimilating the features of the top deck mold to produce the first component;
allowing the first component to cool;
extracting the first component from the top deck mold;
producing a bottom hull mold for a second component of the personal watercraft, the bottom hull mold including a plurality of features for assimilation into the second component, the plurality of features of the bottom hull mold including a mid-rocker feature, a convex groove feature running longitudinally along the bottom hull mold and parallel to a center line of the bottom hull mold, a pump cavity feature, and a second bond rail feature having a shape complementary of the first bond rail;
inserting a second thermoplastic material into the heater;
draping the heated second thermoplastic material over the bottom hull mold;
drawing the heated second thermoplastic material into or over the bottom hull mold using a vacuum to produce the second component;
allowing the second component to cool;
extracting the second component from the bottom hull mold;
trimming excess material from the first component;
trimming excess material from the second component; and
coupling the first bond rail of the first component to the second bond rail of the second component to form the personal watercraft.

US Pat. No. 10,391,701

MOLD BOTTOM WITH WIDE AIR VENTS FOR THE FORMING OF A CONTAINER

SIDEL PARTICIPATIONS, Oc...

1. A mold bottom (20) for a mold (1) for manufacture, by blow molding or stretch blow molding of a parison (3) made of plastic material, of a container (2) that has a bottom (8) with a peripheral seat (9), the mold bottom (20) comprising:a bottom unit (21) that has a molding face (22) in relief bearing the impression of at least a part of the bottom (8) of the container (2), a pressure-release air vent (26) being formed within the unit (21) and emptying out, via an inner opening (27), on the molding face (22) and, via an outer opening (28), into a pipe (29, 30) for exposure to air; and
an insert (34) that is provided with a projection (35) housed in the air vent (26) and that has a terminal face (36) bearing the impression of at least one part of the seat (9) of the container (2),
wherein the insert (34) is provided with an inner circuit (37) for heat regulation of the projection (35),
wherein the insert (34) is mounted to move, in relation to the bottom unit (21), between:
a retracted position in which the terminal face (36) of the projection (35) is separated from the inner opening (27) and permits the inner opening to communicate with the pipe (29, 30) for exposure to air, and
a deployed position in which the terminal face (36) extends in the vicinity of the inner opening (27),
and wherein in the deployed position, the terminal face (36) of the projection (35) extends into the extension of the molding face (22).

US Pat. No. 10,391,681

MOULDING PROCESS

PIXSWEET B.V., (NL)

1. A method of forming a molded item, said method comprising the steps of:(a) providing a mold former comprising an indentation having an inner surface and a bottom face and made of plastics and manufactured by a 3-dimensional printing process, said mold former being shaped to form a mold having:
a series of holes extending between the inner surface and the bottom face of the mold former indentation,
(b) forming the mold in said mold former from a plastics material, wherein the mold has an indentation corresponding to a desired shape of said molded item;
(c) positioning an elongate member in and extending out of said mold such that a first end of the elongate member is received within said mold indentation and a second opposite end of said member is located outside said indentation;
(d) introducing a volume of liquid into said indentation receiving said first end of said elongate member;
(e) positioning a cover over said mold including said mold indentation receiving said first end of said elongate member and sealing the cover to the mold; and
(f) causing said liquid in said covered mold indentation receiving said first end of said elongate member to solidify about said first end of said elongate member.

US Pat. No. 10,391,668

FIREWOOD PROCESSORS

LAITILAN RAUTARAKENNE OY,...

1. A firewood processor, comprisinga saw, arranged to cut and separate a log from wood,
means for feeding wood for the saw,
a splitting chute, arranged to receive at least a part of the log,
a splitting wedge arranged to split the log, of which at least part is arranged in the splitting chute, into pieces,
a pressure plate arranged to support the log while splitting the log, and
a press for moving the pressure plate relative to the splitting wedge in such a way that the log or another log arranged in between the pressure plate and the splitting wedge is configured to be split by said movement, wherein
the splitting wedge is arranged to split the log, of which at least part is arranged in the splitting chute, into at least one intermediate split log and at least one firewood-ready piece, the firewood processor further comprising:
a returning plate configured to return the intermediate split log back to the splitting chute for further splitting,
a protector configured to be in an open position and a closed position, and
a protector position sensor configured to detect a position of the protector, wherein
in the closed position, the protector is arranged to limit an interior of the firewood processor and arranged to protect a user from moving parts of the firewood processor; and
in the open position, the protector is arranged to allow the user to handle at least one of the wood, the log, and the intermediate split log, and
the firewood processor is, after splitting the log, without a user-given control signal or user-given control signals from a controller, and only when the protector is in the closed position, configured to automatically return the intermediate split log, using the returning plate, to the splitting chute.

US Pat. No. 10,391,666

MACHINING DEVICE FOR MACHINING A WORKPIECE BY MEANS OF AT LEAST ONE FLUID JET

MICROWATERJET AG, Aarwan...

1. A machining device for machining a workpiece by means of at least one fluid jet, comprisinga workpiece support for supporting the workpiece, and
a catch basin for dissipating the energy of the at least one fluid jet after its penetration of the workpiece, wherein
the catch basin is arranged in a self-supporting manner in relation to the workpiece support in order to avoid the transmission of vibrations from the catch basin to the workpiece support, and
wherein the catch basin includes side walls, which extend vertically from a bottom of the catch basin beyond a level at which the workpiece support is located such that the workpiece is located within the catch basin, below an uppermost surface of said side walls, thereby allowing the catch basin to be filled with water up to the workpiece.

US Pat. No. 10,391,658

APPARATUS AND METHOD FOR SPIRALLY SLICING MEAT

SF Investments, Inc., Wi...

1. A method for spirally slicing a meat product, comprising:rotating the meat product about a first axis on a turntable with a support apparatus;
stabilizing the rotating the meat product along an outer surface of the meat product with a stabilizer apparatus comprising a paddle constructed of a flexible material coupled with and extending from an arm; and
spirally slicing the meat product in a direction generally transverse to the first axis with a cutting assembly having a knife blade configured transverse to the first axis,
wherein the paddle is placed adjacent to the knife blade on the same side of the product.

US Pat. No. 10,391,637

SELF-PROPELLED ROBOT

MIRAIKIKAI, INC., Kurash...

1. A self-propelled robot that self-travels on a structure having a flat surface to perform operation on the flat surface of the structure, the self-propelled robot, comprising:a robot main body in which a moving unit for the self-travel is provided; and
a controller that controls movement of the robot main body,
wherein the moving unit includes:
one of a wheel and a crawler, the one of the wheel and the crawler running on the flat surface; and
a driving unit that drives the one of the wheel and the crawler, and
the controller has a function of controlling activation of the moving unit such that a rotation plane direction of the one of the wheel and the crawler is substantially orthogonal to an inclination direction of the flat surface when the self-propelled robot is caused to stand still on the flat surface.

US Pat. No. 10,391,619

ACCESSORY FOR A FASTENING GUN

QUICK GRIP STAPLES (HK) L...

1. An accessory for a fastening gun for discharging staples and wherein each staple comprises a crown and a leg on each side of the crown, the accessory comprising:a magazine assembly with a feed end and a discharge end and configured to support a series of staples in a pre-discharge orientation and with a feed mechanism for feeding the staples from the feed end to the discharge end;
a staple drive member, the staple drive member defining first and second opposed generally flat surfaces wherein said first generally flat surface is directed toward said magazine assembly, said staple drive member further having a head with a crown-engaging surface, the head including beveled edges opposite the crown-engaging surface and wherein said beveled edges connect said first and second opposed generally flat surfaces in a direction that is aligned with the legs of each staple in said magazine assembly and wherein an acute angle is formed between said beveled edges and said second opposed generally flat surface, and a shank extending from the head so that the staple driver member has a generally T-shaped appearance, said shank having a longitudinal axis in the direction of movement of said staple drive member and wherein said head is perpendicular to said longitudinal axis; and
a drive member guide assembly including a guide plate, the guide plate fastened to an elongate outer guide member of the magazine assembly and a cover plate that is fastened to the guide plate, an inner surface of the cover plate and the guide plate defining an internal passage in which the head of the drive member can be displaced towards and away from a workpiece and the cover plate and guide plate being configured so that the internal passage also defines a guide path for the staples, once they are fed from a staple guide assembly;
wherein the drive member guide assembly is mounted on the magazine assembly and configured so that a staple drive member is mounted in the drive member guide assembly to be driven and retracted along a predetermined path with respect to the magazine assembly, so that, when driven, the staple drive member can engage a staple to drive legs of the staple into respective components, the drive member guide assembly being configured for mounting on the fastening gun with the staple drive member connected to a piston of the fastening gun.

US Pat. No. 10,391,611

DEVICE AND METHOD FOR CUTTING A GOOD TO BE CUT BY MEANS OF A FLUID

UHDE HIGH PRESSURE TECHNO...

1. A device for cutting a cuttable material with the aid of a fluid, the device comprising:an outlet nozzle;
a pressure-generating unit, wherein the outlet nozzle is fluidically connected to the pressure-generating unit via a fluid line, wherein the pressure-generating unit pressurizes the fluid in the fluid line;
a switching valve; and
a pulsation damper for damping pressure fluctuations from the fluid line, wherein depending on a switching position of the switching valve the pulsation damper is couplable to the fluid line and uncouplable from the fluid line.

US Pat. No. 10,391,609

MODULAR CONTACT ASSEMBLY FOR ROTATING MACHINE TOOL

OptiPro Systems, LLC, On...

1. For a machine tool comprising a housing, a rotating spindle mounted in the housing, and an electrical device mounted in the rotating spindle, a contact assembly comprising:a) a mounting plate joinable to the housing by movement of the plate into an attached position on the housing;
b) a first brush assembly joined to the mounting plate and comprising a first conductive brush movable with respect to the mounting plate and a second conductive brush movable with respect to the mounting plate;
c) a first electrical contact disposed in the mounting plate and in electrical communication with the first conductive brush;
d) a second electrical contact disposed in the mounting plate and in electrical communication with the second conductive brush;
e) an actuator joined to the mounting plate and operable to move the first conductive brush into electrical contact with a first rotating electrical contact ring in electrical communication with the electrical device, and operable to move the second conductive brush into electrical contact with a second rotating electrical contact ring in electrical communication with the electrical device, when the mounting plate is in the attached position; and
f) a first energy supply connection disposed in the mounting plate and in communication with the actuator;
wherein when the mounting plate is moved from a detached position to the attached position and is joined to the housing of the machine tool, the first electrical contact disposed in the mounting plate is electrically connected with a first mating electrical contact disposed in the housing of the machine tool, the second electrical contact disposed in the mounting plate is electrically connected with a second mating electrical contact disposed in the housing of the machine tool, and the first energy supply connection disposed in the mounting plate is connected to a first mating energy supply connection disposed in the housing of the machine tool.

US Pat. No. 10,391,600

FLEXIBLE FIXTURING

MAGNA INTERNATIONAL INC.,...

1. A method for orienting a workpiece on an assembly line to prepare the workpiece for an operation, said method comprising:positioning a flexible fixture on the assembly line, wherein the flexible fixture has a base and at least one adjustable component being moveable relative to the base;
positioning a workpiece on the flexible fixture;
detecting a first orientation of the workpiece relative to the flexible fixture with a detection device and transmitting the detected first orientation from the detection device to a calibrator;
determining a difference between the detected first orientation of the workpiece and a predetermined fixture orientation with the calibrator and transmitting instructions from the calibrator to the flexible fixture to move the workpiece from the detected first orientation to the predetermined fixture orientation with the at least one adjustable component of the flexible fixture based on the determined difference; and
moving the workpiece with the at least one adjustable component from the detected first orientation to the predetermined fixture orientation and fixedly holding the workpiece in the predetermined fixture orientation with the adjustable component;
wherein the detection device is an image capturing device, and wherein detecting the first orientation of the workpiece includes recording at least one image of the workpiece and the flexible fixture with the image capturing device;
wherein detecting the first orientation of the workpiece further includes identifying at least one first angle between the workpiece and the base of the flexible fixture when the workpiece is positioned in the first position, and wherein determining a difference between the detected first orientation of the workpiece and the predetermined fixture orientation includes determining a difference between the at least one identified first angle and at least one fixture angle defined between the workpiece and the base when the workpiece is positioned in the fixture orientation; and
further including calculating movements of the at least one adjustable component of the flexible fixture with the calibrator that will position the workpiece in the predetermined fixture orientation based on the determined differences between the orientation and location of the workpiece in the first orientation and the fixture orientation.

US Pat. No. 10,391,589

FLUX APPLYING DEVICE

Senju Metal Industry Co.,...

1. A flux applying device for applying flux to a surface of solder, the flux applying device comprising:a flux tank where the flux is applied to the surface of the solder by dipping the solder into the flux;
a load applying member being provided at a upstream side of the flux tank, when a side into which the solder enters is set to be the upstream side and a side out of which the solder is discharged is set to be a downstream side;
a constant speed conveyor system that conveys the solder at a predetermined speed, the constant speed conveyor system being provided at a downstream side of the flux tank, the solder to which the flux is applied by the flux tank being pulled up vertically in relation to a liquid surface of the flux, wherein the constant speed conveyor system includes a winder, and further an interlayer paper sheet supplying roller that supplies an interlayer paper sheet when winding the solder by the winder;
a dryer that dries the solder to which the flux is applied, the dryer being provided at the downstream side of the flux tank;
a cooler that cools the dried solder;
a conveying speed measurement sensor that measures a conveying speed of the solder; and
a control system that controls the conveying speed of the solder,
wherein the load applying member acts together with the constant speed conveyor system to apply tension to the solder.

US Pat. No. 10,391,586

METHOD FOR LASER-MARKING OF ANODIZED ALUMINUM

Coherent, Inc., , CA (US)...

1. A method of marking a workpiece of aluminum covered by an anodically formed, corrosion resistant aluminum oxide layer, comprising:irradiating the aluminum, through the oxide-layer, with repeated bursts of two or more optical pulses while scanning the bursts of pulses over the workpiece surface, each location on the workpiece that is irradiated receiving at least one burst of consecutive optical pulses, the temporal separation of consecutive pulses in the bursts thereof being less than about 25 nanoseconds, the repetition frequency of the bursts being at least about 400 kilohertz, and the fluence level of an individual pulse in a burst on the workpiece surface is less than about 0.1 Joules per square centimeter in order to mark the workpiece without compromising the corrosion resistance of the aluminum oxide layer.

US Pat. No. 10,391,579

VENTILATED VIBRATING ELECTRODE HOLDER

HUYS INDUSTRIES LIMITED, ...

1. An electrode holder for a consumable welding material electrode, said electrode holder comprising:a handle by which an operator grasps said electrode holder;
said handle being made of an electrical insulator;
an electrode seat for a consumable welding material electrode rod, said electrode seat being mounted to said handle;
said electrode holder has a housing, said housing having a shape defining said handle;
an electrically conductive member mounted to said handle, said electrically conductive member having a first end at which to receive power from an electrical power source, and a second end in electrically conductive connection with said electrode seat, in use, said electrically conductive member being operable to carry electrical current from said power source to melt the electrode rod;
a vibration source mounted to said handle, said vibration source being operable to vibrate said electrode seat relative to said handle;
said vibration source being mounted within said housing, said vibration source includes an exciter; and said exciter includes a rotating eccentric;
said electrically conductive member is a beam;
said rotating eccentric is mounted to a shaft beside said beam; and
said beam conducts both electricity and vibration to said electrode seat.

US Pat. No. 10,391,568

POWER TOOL SYSTEM

Robert Bosch GmbH, Stutt...

1. A machine-tool system comprising:at least one machine tool including at least one workpiece-bearing unit configured to support a workpiece during machining, and a drive unit operably coupled to at least one movably mounted tool-guide unit, the tool-guide unit having a transmission unit arranged at least partially within a tool-guide rod of the tool-guide unit, the tool-guide rod slidably received within a tool-guide bearing block, the movably mounted tool-guide unit pivotably attached to the at least one workpiece-bearing unit and pivotable about a pivot axis which is perpendicular to a bearing surface of the at least one workpiece-bearing unit; and
at least one machine-tool severing device removably arranged on the tool-guide unit, wherein the machine-tool severing device includes at least one cutting strand and at least one guide unit configured to guide the at least one cutting strand, the cutting strand having an internal circumference smaller than an external circumference of the at least one guide unit, such that the at least one cutting strand is retained on the at least one guide unit when the machine-tool severing device is removed from the tool-guide unit, wherein the at least one machine-tool severing device, in at least one operating state, is mounted such that the at least one machine-tool severing device is displaceably guided by the tool-guide unit at least essentially parallel to a bearing surface of the at least one workpiece-bearing unit.

US Pat. No. 10,391,536

TOOL KIT FOR BENDING A METAL TRAY

1. A tool kit for bending a metal tray comprising:a middle bending tool further comprising:
a solid cylindrical middle lower handle having a bottom end, a top end, and a middle gripping member disposed over the bottom end; and
a C-shaped middle top clamping member having a rectangular middle top plate, a rectangular middle bottom plate, a middle rear portion disposed between the middle top plate and the middle bottom plate, and a middle opening disposed between the middle top plate and the middle bottom plate, wherein the middle bottom plate is substantially medially welded to the top end of the middle lower handle;
wherein the middle lower handle is perpendicularly extended from the middle bottom plate of the middle top clamping member;
a right bending tool further comprising:
a solid cylindrical right lower handle having a lower end, an upper end, and a right gripping member disposed over the lower end; and
a C-shaped right top clamping member having a right surface, a left surface, a square-shaped right top plate, a square-shaped right bottom plate, a middle rear section disposed between the right top plate and the right bottom plate, and a right opening disposed between the right top plate and the right bottom plate, wherein the right bottom plate is substantially medially welded to the upper end of the right lower handle;
wherein the right lower handle is extended at a forty-five degree angle from the right bottom plate of the right top clamping member toward the right surface;
a left bending tool further comprising:
a solid cylindrical left lower handle having a bottom side, a top side, and a left gripping member disposed over the bottom side; and
a C-shaped left top clamping member having a right area, a left area, a square-shaped left top plate, a square-shaped left bottom plate, a left rear section disposed between the left top plate and the left bottom plate, and a left opening disposed between the left top plate and the left bottom plate, wherein the left bottom plate is substantially medially welded to the top side of the left lower handle;
wherein the left lower handle is extended at a forty-five degree angle from the left bottom plate of the left top clamping member toward the left area;
wherein each of the right opening of the right top clamping member of the right bending tool, the middle opening of the middle top clamping member of the middle bending tool, and the left opening of the left top clamping member of the left bending tool removably and slidably engages an edge of a metal tray;
wherein each of the right top clamping member of the right bending tool, the middle top clamping member of the middle bending tool, and the left top clamping member of the left bending tool is configured to bend the metal tray to a shape desired by a user.

US Pat. No. 10,391,533

METHOD FOR PRODUCING A MOTOR VEHICLE COMPONENT FROM AN EXTRUDED LIGHT METAL PROFILE

BENTLER AUTOMOBILTECHNIK ...

1. Method for producing a motor vehicle component, the method comprising:extruding a 5000 series, 6000 series, or 7000 series aluminum alloy as an extruded profile having, in cross section, at least two mutually different wall thicknesses and at least one closed hollow chamber and an extrusion width,
at least partially flattening and/or widening the cross section to a processing width, wherein the processing width is at least 10% greater than the extrusion width,
after the flattening and/or widening, performing separation of the extruded profile to obtain a blank,
processing the blank by deformation of the blank to form the motor vehicle component.

US Pat. No. 10,391,523

SENSOR WASHING DEVICE

Methode Electronics, Inc....

1. A sensor washing device, comprising:a washer housing including a ring portion and a fluid source attachment, said fluid source attachment being configured to receive fluid, and said ring portion having,
a main opening for receiving a detecting head of the sensor,
an attachment side configured for mounting said washer housing, and
a washing side configured to frame the detecting head of the sensor, said washing side being in fluid communication with said fluid source attachment, and
a plurality of nozzles being disposed in a transition portion of said washer housing between said ring portion and said fluid source attachment of said washer housing, said plurality of nozzles being configured to discharge fluid to said washer side radially inwardly towards said main opening for cleaning the detecting head of the sensor, and said plurality of nozzles being defined by a plurality of tabs extending from said transition portion toward said main opening of said ring portion, thereby forming fluid path slots of said plurality of nozzles therebetween,
wherein said washer housing, said ring portion, and said transition portion are stationary with respect to one another.

US Pat. No. 10,391,495

DEFORMABLE WELL AND METHOD

Wisconsin Alumni Research...

1. A deformable well structure for a microtiter plate, comprising:a sample container including a generally cylindrical wall at least partially defining a well for receiving a sample therein; and
a deformation tool including a fixture having:
a support bar; and
a recessed surface in the support bar defining a recess and being engageable with the wall of the sample container, the recessed surface having a position fixed relative to the support bar;wherein:one of the sample container and the fixture being moveable between a first disengaged position wherein the sample container is spaced from the recessed surface in the support bar and a second engaged position wherein the sample container is received in the recess in the support bar and engages the recessed surface in the support bar;
the recessed surface defining the recess in the support bar deforms at least a portion of the sample container with the sample container received in the recess such that the meniscus of the sample in the well is convex;
the sample container has a first cross-sectional dimension greater than a cross-sectional dimension of the recess in the first disengaged position and in the second engaged position such that the recessed surface deforms the sample container as the sample container and the fixture are relatively moved from the first disengaged position to the second engaged position.

US Pat. No. 10,391,469

SORBENT SYSTEMS AND METHODS

HAMILTON SUNDSTRAND CORPO...

1. A sorbent bed, comprising:a sorbent support comprising at least one of a carbon material, a polymeric material, or alumina, wherein the sorbent support comprises a plurality of pores; and
an impregnant configured to absorb ammonia disposed within the plurality of pores in the sorbent support, wherein the sorbent bed comprises greater than 50% and up to 60% by weight impregnant, and wherein the impregnant comprises at least one of phosphoric acid or zinc chloride.

US Pat. No. 10,391,468

HALOGENATION OF HYDROCARBONS

RELIANCE INDUSTRIES LIMIT...

1. A process for halogenation of a hydrocarbon; said process comprising the following steps:i. introducing the hydrocarbon in a reaction vessel;
ii. initially agitating the hydrocarbon in said reaction vessel at a speed of 200 rpm with a centrally mounted stirrer in said reaction vessel for an initial time period of 5 minutes;
iii. increasing said speed of 200 rpm to a speed of 650 rpm and stirring the hydrocarbon at said speed of 650 rpm with said centrally mounted stirrer in said reaction vessel for a time period of 40 minutes;
iv. introducing a halogen in the reaction vessel while stirring the hydrocarbon at said speed of 650 rpm with said centrally mounted stirrer in said reaction vessel for said time period of 40 minutes; and
v. passing light of wavelength in the range of 390 to 780 nm emitted by a plurality of solid state light emitting devices placed outside said reaction vessel at a distance of 0.5 to 4 cm from the exterior wall of said reaction vessel, into said reaction vessel for a period of time to obtain a halogenated hydrocarbon,
wherein, said process steps of (ii) and (iii) are carried out in an inert atmosphere.

US Pat. No. 10,391,467

FABRICATION OF PATTERNED ARRAYS

CENTRILLION TECHNOLOGY HO...

1. A method for generating an array comprising:providing a template array comprising at least 1,000 different oligonucleotides coupled thereto,
coupling the template array to a recipient array having a plurality of oligonucleotides complementary to portions of the at least 1,000 different oligonucleotides, and
performing an enzymatic reaction while each of the at least 1,000 different oligonucleotides of the template array hybridizes with a member of the plurality of oligonucleotides of the recipient array, thereby generating a recipient array comprising recipient oligonucleotides, wherein at least 40% of the recipient oligonucleotides are complementary to a full-length oligonucleotide from the at least 1,000 different oligonucleotides, wherein each of the at least 1,000 different oligonucleotides comprises a barcode, and wherein the barcode identifies the spatial position of each of the at least 1,000 different oligonucleotides.

US Pat. No. 10,391,463

SYSTEM FOR MIXING A CHEMICAL PRODUCT WITH WATER

EXEL INDUSTRIES, Epernay...

1. Phytosanitary product mixing system for mixing a phytosanitary chemical product with water, comprising a water inlet port designed to be connected to a pressurized water supply pipe, a chemical product inlet port designed to be connected to a chemical product reservoir, and a mixture outlet port, wherein it comprises a main chamber in which a piston is movable and delimits an upstream part of the main chamber that is fluidically connected to the water inlet port and a downstream part of the main chamber that is connected to the chemical product inlet port, wherein the piston is provided with a rod extending into the downstream part of the main chamber, wherein the water inlet port is also connected to the mixture outlet port, wherein the downstream part of the main chamber is also connected to the mixture outlet port, wherein a water flow regulating device is interposed between the upstream part of the main chamber and the water inlet port, and wherein the piston is movable in the main chamber under the action of water entering the upstream part of the main chamber and the pressure difference created by the rod of the piston in the downstream part of the main chamber, so that the chemical product contained in the downstream part of the main chamber is directed towards the outlet port, wherein the mixing system is arranged for operation in a plurality of operating modes and comprises a control member operable by a user to select a desired one of the operating modes of the system by controlling at least one valve arranged for regulating flows in the system of at least one of phytosanitary chemical product, water and a mixture of the phytosanitary chemical product and water; andwherein the plurality of operating modes comprise:
a first mode for filling the main chamber with the phytosanitary chemical product;
a second mode for mixing the phytosanitary product with water for output via the mixture outlet port; and
a third mode for cleaning the system.

US Pat. No. 10,391,457

POROUS FILTER

SUMITOMO ELECTRIC FINE PO...

1. A porous filter comprising a porous laminate in which a plurality of biaxially stretched porous sheets made of PTFE are stacked,wherein the porous laminate includes a pair of support layers and a retention layer disposed between the pair of support layers,
the average thickness of the retention layer is from 8 ?m to 25 ?m,
the mean pore diameter of the retention layer is from 0.01 ?m to 0.45 ?m,
the porosity of the retention layer is from 50% to 90%,
the average thickness of each support layer is from 2 ?m to 20 ?m,
the mean pore diameter of each support layer is from two times to ten times the mean pore diameter of the retention layer,
the porosity of each support layer is from one time to two times the porosity of the retention layer,
the porous laminate is formed by stacking the support layers on opposite sides of the retention layer such that the retention layer is sandwiched between the support layers, and heating the resulting laminate such that the individual layers are fusion bonded to one another at the boundaries thereof, wherein the laminate is heated at a temperature of 327° C. to 400° C. for a period of 0.5 minute to 3.0 minutes to form an integrated structure, and
wherein G is the coefficient of the Gurley number of the porous laminate, B is the coefficient of the bubble point of the porous laminate, and the coefficients of the Gurley number and the bubble point satisfy the following expressions (1) and (2):
log G>3.7×10?3×B?0.8  (1)
log G<4.9×10?3×B+0.45  (2)wherein, the Gurley number is measured in seconds (s) and the bubble point is measured in kilopascal (kPa).

US Pat. No. 10,391,455

FILTRATION AND EMULSIFICATION DEVICE

MST MICROSIEVE TECHNOLOGI...

1. A device for treatment of substances, comprising:at least one membrane medium comprising a first side configured to face an unfiltered phase of a substance and a second side configured to face a filtered phase of the substance; and
a housing in which the at least one membrane medium is stationary or adapted to be rotated, the housing comprising:
at least one feed inlet for the unfiltered phase of the substance,
at least one overflow outlet for the unfiltered phase of the substance,
at least one rotatable channel for drainage of the filtered phase of the substance, and
a suction device configured to produce vacuum on regions of the at least one membrane medium on the side facing the unfiltered phase of the substance, the suction device comprising at least one suction slot arranged parallel to the at least one membrane medium at a distance of 0.1 mm to 0.5 mm from the membrane medium,
wherein the at least one membrane medium is a plurality of membrane media each associated with a respective membrane support element and the suction device comprises a plurality of suction elements each associated with a respective membrane medium, and
wherein the membrane support elements and the suction elements are alternately stacked on top of each other onto a sleeve shaft.

US Pat. No. 10,391,449

NANOFIBER AUGMENTED DIESEL PARTICULATE FILTERS

Cummins Emission Solution...

1. A particulate filter for use in an exhaust aftertreatment system, the particulate filter comprising:a porous ceramic substrate comprising pores; and
a plurality of ceramic nanofibers that are distinct from the porous ceramic substrate and that are associated with the pores of the porous ceramic substrate.

US Pat. No. 10,391,438

FILTER ASSEMBLY AND CLEANER HAVING THE SAME

Midea Group Co., Ltd., F...

1. A filter assembly, comprising:a tank configured to accommodate a liquid therein and having an air inlet and an air outlet; and
an air intake pipe connected to the air inlet, having an air output end located in the tank and extending towards the liquid or submerged in the liquid, and having a cross sectional area gradually increased along a fluid flow direction inside the air intake pipe.

US Pat. No. 10,391,422

CHROMATOGRAPHY COLUMN

GE HEALTHCARE BIO-SCIENCE...

1. A chromatography column, having a longitudinal axis, comprising:a column wall with an upper first end and a lower second end;
a first end plate assembly removably connectable to the first end of the column wall;
a second end plate assembly removably connectable to the second end of the column wall;
extendable legs provided with a lifting means; and
a movable adapter, movable along the longitudinal axis from a position inside the column wall to a position outside the column wall,
wherein the first end plate assembly, the column wall, and the second end plate assembly are arranged along the longitudinal axis, and wherein the column wall is rotatable about an axis of rotation that is parallel to the longitudinal axis of the column and positioned outside the column and wherein at least the first end plate assembly and the movable adapter are raiseable by the lifting means at least until the lowest part of the movable adapter is above a top of the column wall.

US Pat. No. 10,391,402

APPARATUS FOR ADAPTING VIRTUAL GAMING WITH REAL WORLD INFORMATION

STEELSERIES ApS, Frederi...

1. A machine-readable storage medium, comprising executable instructions that, when executed by a communication device including a processor, facilitate performance of operations, comprising:receiving first information representative of a computer-controlled avatar generated by a gaming application, wherein the computer-controlled avatar is mapped by the gaming application to a first position at a physical region;
determining a second position of the communication device at the physical region;
presenting the computer-controlled avatar superimposed onto a depiction of at least a portion of the physical region at a display associated with the communication device according to the first information representative of the computer-controlled avatar, wherein the first position of the computer-controlled avatar is depicted relative to the second position of the communication device;
receiving, from a user interface, a first user input;
generating a first input stimulation according to the first user input;
detecting an association between the first input stimulation and a gaming application action associated with the gaming application, wherein the gaming application action comprises targeting of the computer-controlled avatar;
retrieving a substitute stimulation for the first input stimulation according to a single input macro defined for the gaming application, wherein the single input macro defines an association between the gaming application action and the substitute stimulation, wherein the substitute stimulation is provided to the gaming application as second information associated with the gaming application action, wherein the substitute stimulation is associated with the single input macro according to a recommendation generated by the communication device based on monitoring of user inputs during use of the gaming application;
detecting according to third information provided by the gaming application responsive to the second information an occurrence of a virtual hit of the computer-controlled avatar based on the targeting of the computer-controlled avatar; and
responsive to detection of the virtual hit of the computer-controlled avatar, presenting the virtual hit at the display.

US Pat. No. 10,391,386

VIDEO GAME PROCESSING APPARATUS AND VIDEO GAME PROCESSING PROGRAM

KABUSHIKI KAISHA SQUARE E...

1. A video game processing apparatus for controlling progress of a video game in response to an input received from a player, the video game processing apparatus comprising:a memory configured to store operational correspondence information, the operational correspondence information including a relationship of a plurality of inputs arranged on one input device with a plurality of gameplay operations, each of the gameplay operations corresponding to an input of the one input device, and at least one of the inputs of the one input device corresponding to two or more gameplay operations;
a display controller configured
to control an image display device to simultaneously display, on a display screen of the image display device, a plurality of virtual image sets including at least a first virtual image set and a second virtual image set, the plurality of virtual image sets corresponding to the one input device, each virtual image set having a plurality of virtual images each corresponding to a gameplay operation executable by an input of the one input device, the first virtual image set corresponding to a first set of gameplay operations and the second virtual image set corresponding to a second set of gameplay operations, such that an input of the one input device executes, at a time, one of a gameplay operation of the first set of gameplay operations or a gameplay operation of the second set of gameplay operations, and
to control the image display device to distinguishably display an active set of the virtual images among at least the first virtual image set and the second virtual image set to allow identification of active gameplay operations associated with the corresponding input, wherein only one of the plurality of virtual image sets being activated at a time according to a selection by the player;
an input receiver configured to receive, from the player, a selection of the input of the one input device; and
a processor configured to execute a gameplay operation corresponding to the one input device selected by the player, the gameplay operation being executed corresponding to the active set of the virtual images but not an inactive set of virtual images,
wherein only one of the plurality of virtual image sets is set as the active set of virtual images at a time using a switching operation executed by the one input device, and
wherein the switching operation is executed during the gameplay.

US Pat. No. 10,391,365

TOSSING BALLS

Acorn Products, LLC, Mon...

1. A tossing ball, comprising;a plurality of interconnected resilient ribs forming a resilient skeletal body of the tossing ball; wherein the resilient skeletal body defines an open internal volume of the tossing ball and a plurality of passages between adjacent resilient ribs of the plurality of interconnected resilient ribs; wherein the resilient skeletal body has an outwardly facing body portion and an inwardly facing body portion; and further wherein each of the plurality of passages extends from the outwardly facing body portion of the resilient skeletal body to the open internal volume; and
an array of force-absorbing resilient fingers extending from the plurality of interconnected resilient ribs; wherein the tossing ball has a nominal configuration in which the array of force-absorbing resilient fingers extend away from the open internal volume of the tossing ball; wherein each force-absorbing resilient finger of the array of force-absorbing resilient fingers has a length, and each force-absorbing resilient finger of the array of force-absorbing resilient fingers has a longitudinal axis projecting transversely from a corresponding resilient rib of the plurality of interconnected resilient ribs; wherein at least 75% of the length of each force-absorbing resilient finger extends along the longitudinal axis.

US Pat. No. 10,391,360

METHOD AND DEVICE FOR OPTIMIZING THE TRAINING OF ATHLETES

Myotest SA, Scion (CH)

1. A method for optimizing training of athletes, comprising the steps of:during an initial test, automatically measuring with an three-axis accelerometer of a single portable device, a series of acceleration values during a series of N short movements performed by an athlete, said single portable device being arranged to generate a signal for initiating the initial test and a signal for ending the initial test;
operating said single portable device so that it:
calculates a plurality of muscular parameters based on said series of acceleration values, wherein said plurality of muscular parameters include at least four different muscular parameters, wherein said plurality of muscular parameters comprise extension, reactivity, muscular stiffness, and coordination,
determines among said plurality of muscular parameters, M weakest muscular parameters of the athlete, each of the M weakest muscular parameters being different, and wherein M is a positive integer greater than one, and
automatically selects, on the basis of said initial test and said M weakest muscular parameters, a set of training exercises personalized for said athlete, said set of training exercises comprising a personalized session of interval running, said personalized session including periods of runs at various particular paces and short gymnastic exercises between said periods,
presenting, by a display of said single portable device, said set of training exercises to said athlete;
executing, by the athlete, said set of training exercises;
operating said single portable device to
measure acceleration values during execution of the set of training exercises, so as to directly measure said plurality of muscular parameters of the athlete during the execution of said set of training exercises,
check, during and/or after the execution of the set of training exercises, if the athlete has improved the M weakest muscular parameters, and
use the measured acceleration values to automatically verify correct execution of said set of training exercises, by computing results after each exercise of said set of training exercises, and/or by indicating incorrect execution of an exercise of set of training exercises by audio and/or text signals,
wherein said three-axis accelerometer comprises one or more preferential axes, offering greater precision, resolution and/or measurement range than in the other axes, and
wherein one of the one or more preferential axes is aligned vertically when the single portable device is in its normal use position, so as to improve the measurements in the vertical direction.

US Pat. No. 10,391,345

LASER MATERIAL PROCESSING SYSTEMS CONFIGURED TO SUPPRESS SELF-SUSTAINED COMBUSTION, AND ASSOCIATED APPARATUSES AND METHODS

UNIVERSAL LASER SYSTEMS, ...

1. A laser material processing system, comprising:a laser material processing region including a processing chamber and a laser beam delivery apparatus within the processing chamber;
one or more sensors disposed in the laser material processing region and configured to detect self-sustained combustion in the laser material processing region;
an air inlet positioned to draw a flow of air through the laser material processing region;
an exhaust outlet for exhausting the air from the laser material processing region;
and two or more suppressant delivery ports positioned in or adjacent to the laser material processing region,
wherein the suppressant delivery ports include a first suppressant delivery port at a first wall of the processing chamber and a second suppressant delivery port at a second wall of the processing chamber, and wherein the first and second walls are at opposite sides of the processing chamber,
wherein the laser material processing system is configured to distinguish between non-self-sustained combustion and self-sustained combustion, and
wherein the first and second suppressant delivery ports are configured to deliver a suppressant to the laser material processing region when at least one of the one or more sensors detects the presence of self-sustained combustion.

US Pat. No. 10,391,343

FLEXIBLE DRY SPRINKLERS

The Reliable Automatic Sp...

1. A flexible dry fire protection sprinkler comprising:(A) an inlet having an inlet orifice;
(B) an inlet seal assembly configured to seal the inlet orifice;
(C) an inlet release unit configured to release the inlet seal assembly, the inlet release unit including a spacer having an inner annular flange, and a collar provided on a side of the inner annular flange that faces the inlet, the collar interfering with the inner annular flange;
(D) a flexible tube having an inlet end connected to the inlet release unit, and an outlet end;
(E) a flexible linkage extending through the flexible tube, and having an inlet end connected to the collar of the inlet release unit by crimping, and an outlet end;
(F) an outlet biasing portion connected to the outlet end of the flexible tube and to the outlet end of the flexible linkage, and configured to displace the outlet end of the flexible linkage upon activation of the flexible dry fire protection sprinkler;
(G) a sprinkler body connected to the outlet biasing portion, the sprinkler body having an outlet orifice; and
(H) an outlet seal assembly configured to seal the outlet orifice of the sprinkler body until ambient temperature reaches a predetermined temperature,
wherein, when the ambient temperature reaches the predetermined temperature, the outlet seal assembly is released from the outlet orifice of the sprinkler body, and the outlet biasing portion displaces the flexible linkage in an outlet direction from a first position to a second position, causing the inlet end of the flexible linkage to operate the inlet release unit, thereby releasing the inlet seal assembly from the inlet orifice of the inlet.

US Pat. No. 10,391,329

METHODS FOR IMPROVING NEURAL COMMUNICATION BETWEEN TISSUE REGIONS

KOSIVANA HOLDINGS LIMITED...

1. A method of improving neural communication through an interface between a first distinct region of tissue and a second distinct region of tissue in the body of a person, the method comprising administering repetitive magnetic field pulses synchronously at a magnetic pulse frequency to both regions of tissue, wherein the magnetic pulse frequency changes periodically about an average target frequency that is 30 Hz or less.

US Pat. No. 10,391,319

TRANS SEPTAL IMPLANTABLE MEDICAL DEVICE

CARDIAC PACEMAKERS, INC.,...

1. An implantable medical device (IMD) configured for deployment at a ventricular septum of a patient's heart, the ventricular septum of the patient's heart having a right ventricle (RV) facing side and a left ventricle (LV) facing side, the IMD comprising:a housing having a proximal end and a distal end, the housing configured to fit within the right ventricle (RV) of the patient's heart with the distal end of the housing proximate the RV facing side of the ventricular septum once the IMD is implanted in the patient's heart;
a power source disposed within the housing;
circuitry disposed within the housing and operatively coupled to the power source;
a first RV electrode adjacent the distal end of the housing and positioned to be facing the RV facing side of the ventricular septum once the IMD is implanted, the first RV electrode operatively coupled with the circuitry in the housing;
a second RV electrode spaced proximally of the first RV electrode, the second RV electrode operatively coupled with the circuitry in the housing;
an LV electrode positioned distally of the first RV electrode and extends at least partially through the ventricular septum once the IMD is implanted, the LV electrode operatively coupled with the circuitry in the housing; and
an LV electrode position adjustment assembly for adjusting a distance that the LV electrode is positioned distally of the first RV electrode, wherein the LV electrode position adjustment assembly comprises a coupling secured relative to the housing, wherein the coupling is configured to mate with a separate adjustment tool that can move the coupling relative to the housing to adjust the distance that the LV electrode is positioned distally of the first RV electrode.

US Pat. No. 10,391,314

SYSTEMS AND RELATED METHODS FOR OPTIMIZATION OF MULTI-ELECTRODE NERVE PACING

Lungpacer Medical Inc., ...

1. A method for determining a relationship between charge and diaphragm response for an electrode combination, comprising:inserting a plurality of electrodes into one or more blood vessels of a patient, wherein the plurality of electrodes include the electrode combination;
using the electrode combination, stimulating a phrenic nerve with a plurality of stimulation pulses, wherein each stimulation pulse includes a corresponding charge, and the corresponding charges differ among the plurality of stimulation pulses;
determining a recruitment curve relating the corresponding charges to diaphragm responses resulting from the corresponding charges, wherein the recruitment curve also relates undelivered charges to diaphragm responses expected from the undelivered charges; and
after determining the recruitment curve: a) stimulating the phrenic nerve with the electrode combination, b) using the recruitment curve, determining an expected diaphragm response, to the stimulation, and c) comparing an actual diaphragm response to the expected diaphragm response.

US Pat. No. 10,391,310

FLEXIBLE AND STRETCHABLE ELECTRODES FOR GASTROINTESTINAL IMPLANTS

THE REGENTS OF THE UNIVER...

1. An apparatus for controlling peristalsis of a section of gastrointestinal tract, comprising:(a) a first segment of a resilient electrode array of one or more stimulation electrodes, one or more recording electrodes and one or more adhesion nodes coupled together with flexible spring structures, said first segment configured for adhesion to an upper section of normal gastrointestinal tract;
(b) a second segment of a resilient electrode array of one or more stimulation electrodes, one or more recording electrodes and one or more adhesion nodes coupled together with flexible spring structures, said second segment configured for adhesion to a section of incapable gastrointestinal tract;
(c) a third segment of a resilient electrode array of one or more stimulation electrodes, one or more recording electrodes and one or more adhesion nodes coupled together with flexible spring structures, said third segment configured for adhesion to a lower section of normal gastrointestinal tract; and
(d) a controller coupled to the stimulation electrodes and recording electrodes, said controller configured to produce electrical pulses to the stimulation electrodes and to sense peristaltic activity with the recording electrodes and produce sensed signals;
(e) wherein said recording electrodes of said first segment sense normal peristalsis;
(f) wherein said recording electrodes of said second and third segments sense electrostimulation contractions; and
(g) wherein electric stimulation pulses sent from the controller to the incapable intestine section to produce the contraction are based on recording and analysis of the sensed signals from the recording electrodes of the segments.

US Pat. No. 10,391,305

TELESCOPING CATHETER DELIVERY SYSTEM FOR LEFT HEART ENDOCARDIAL DEVICE PLACEMENT

Medtronic, Inc., Minneap...

1. A method of transseptal delivery of an instrument into a heart, comprising:employing an elongate first tubular member defining a first lumen extending between a proximal end and a distal end of the first tubular member, the first tubular member having an adjustable portion adjacent its distal end and an elongate second tubular member received within the first tubular member, the second tubular member defining a second lumen extending between a proximal end and a distal end of the second tubular member, the second lumen adapted to receive a puncturing tool and an instrument to be placed in the heart, the second tubular member having a curved portion adjacent its distal end in a relaxed state; by:
a) advancing the first tubular member such that it extends through a superior entry point into a right atrium of the heart;
b) deflecting the adjustable portion of the first tubular member toward an atrial septum of the heart;
c) guiding the puncturing tool through the second tubular member and creating a septal puncture;
d) inserting the second tubular member through the septal puncture into a left atrium of the heart;
e) with the first tubular member remaining in the right atrium and with the second tubular member extending through the septal puncture into the left atrium, orienting the curved portion of the second tubular member toward a left ventricle of the heart;
f) advancing a guide through the second tubular member into the left ventricle;
g) with the first tubular member remaining in the right atrium, advancing the second tubular member along the guide into the left ventricle;
and
h) with the first tubular member remaining in the right atrium and the second tubular member extending into the left ventricle, advancing the instrument into the left ventricle.

US Pat. No. 10,391,303

TOOLS AND METHODS FOR IMPLANTATION OF IMPLANTABLE MEDICAL LEAD EXTENSIONS OR CATHETERS

MEDTRONIC, INC., Minneap...

1. A tool for pulling an implantable medical lead extension through a subcutaneous tunnel, comprising:a handle;
a shaft having a first end and a second end, the first end being coupled to the handle;
a tip coupled to the second end of the shaft, the tip comprising a pin having a first end that is sized to be inserted into a bore of a connector body located on a distal end of the implantable lead extension and the tip comprising a second end, the tip further comprising a barb positioned on the pin and spaced axially from the first end of the pin, the barb being sized to create an interference fit within a compliant distal portion of the connector body, the barb having a first barb portion that slopes from a largest barb diameter to a smallest barb diameter where the smallest diameter of the barb is closer to the first end of the tip than the largest diameter of the barb, and the barb has a second portion that extends axially from the first portion towards the second end of the tip that is opposite the first end the second end of the tip being attached to the shaft, and with the second barb portion being the largest barb diameter, the second end of the tip having a diameter at the attachment to the shaft equal to the largest diameter of the barb, wherein the tip further comprises a first pin section and a second pin section, the second pin section comprising a first section end that is blunt and the first section end that is blunt has a larger diameter than an entire axial length of the first pin section, and the second pin section further comprising a second section end where the second section end provides the second end of the pin, the second pin section having a constant diameter from the first section end to the second section end, the first pin section interconnecting the second portion of the barb and the first section end of the second pin section where the first pin section has a diameter larger than the smallest diameter of the barb and smaller than the largest diameter of the barb.

US Pat. No. 10,391,299

INTERVENTIONAL MEDICAL SYSTEMS FOR THERAPY DELIVERY IN EXTRACARDIOVASCULAR SPACES AND ASSOCIATED TOOLS AND METHODS

Medtronic, Inc., Minneap...

1. A tool for inserting an elongate medical device into a body of a patient, the tool comprising:a handle;
a guide including:
a proximal end coupled to the handle,
a distal terminal end, and
an elongate track extending along a longitudinal axis of the tool from the proximal end to the distal terminal end of the guide, the track being formed from a base wall and a pair of opposing sidewalls of the guide, the base wall extending between the sidewalls such that inner surfaces thereof define the track, the track including a track proximal segment extending distally from the proximal end of the guide, a track distal segment extending from the track proximal segment to the distal terminal end of the guide, and a stop feature located at an intersection of the track proximal segment and the track distal segment; and
a deployment assembly configured to receive the device therein and to move the device along the track of the guide, the deployment assembly comprising:
a retainer including:
a proximal end;
a distal end;
a pair of opposing sidewalls,
a joining wall extending between the retainer sidewalls such that inner surfaces of the retainer side walls and the retainer joining wall define an open channel that extends from the retainer proximal end to the retainer distal end, the open channel being configured to receive and grip the device therein, the retainer fitting in sliding engagement within the track of the guide such that the inner surface of the joining wall faces away from the inner surface of the guide base wall, and
a projecting member configured to engage with the stop feature of the track; and
a slider detachably joined to the retainer, the slider including:
a proximal end;
a distal end;
a pair of opposing sidewalls; and
a joining wall extending between the slider sidewalls such that inner surfaces thereof define an open channel of the slider that extends from the slider proximal end to the slider distal end, the slider open channel being sized to receive the device therein and being continuous with the retainer open channel, the slider fitting in sliding engagement within the track of the guide such that the inner surface of the slider joining wall faces toward the track.

US Pat. No. 10,391,298

METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE USING ELECTRICAL ENERGY

Ethicon LLC, Guaynabo, P...

1. A medical apparatus, comprising:a device configured to be positioned in contact with tissue of a patient and configured to be activated, when so positioned, to deliver an electrical signal to the patient using an electrode of the device and thereby activate a first type of neurons in brown adipose tissue (BAT) of the patient without activating a second, different type of neurons in the BAT.

US Pat. No. 10,391,293

MEDICAL CONNECTORS AND METHODS OF USE

ICU Medical, Inc., San C...

1. A medical connector configured to be removably attached to a medical implement having a male luer tip, the medical connector comprising:a housing comprising a proximal body member and a base member;
the proximal body member comprising a proximal opening, a distal end, and an internal abutment surface that is located distal from the proximal opening of the body member, but closer to the proximal opening of the body member than to the distal end of the body member, the abutment surface comprising a proximal end, a distal end, and a slanting wall extending between the proximal and distal ends such that the distal end of the abutment surface is wider than the proximal end of the abutment surface;
a base member coupled to the proximal body member, the base member comprising a distally extending male end;
an internal cavity formed between the proximal body member and the base member;
an elastomeric seal member located within the internal cavity, the seal member comprising a proximal end with a septum having a vertical thickness and a slit biased to a closed position, a distal end, an interior region, and an elastomeric collar located distal from the proximal end of the seal member but closer to the proximal end of the seal member than to the distal end of the seal member, a vertical thickness of the collar being greater than the vertical thickness of the septum, the seal member being configured to move between a closed position and a compressed open position when the male luer tip of the medical implement is inserted into the proximal opening of the proximal body member, such that the proximal end of the seal member moves distally in transitioning from the closed position to the open position; and
a rigid, hollow elongated portion located within the seal member, the elongated portion comprising a closed, non-sharp proximal tip with a proximally facing top surface with a transverse width positioned within the interior region of the seal member distally below the septum of the seal member in the closed position, such that an open space is provided in the interior region of the seal member between the proximal tip of the elongated portion and a distal side of the septum, the open space not being narrower than the transverse width of the proximally facing top surface of the proximal tip of the elongated portion, permitting the compressing seal member to advance unimpeded distally with respect to the elongated portion from the closed to the open position to expose the elongated portion proximally outside of the seal member, one or more side openings spaced distally from the proximal tip, and an internal fluid passageway in fluid communication with the one or more side openings, each of the side openings comprising a proximal end and a distal end, the proximal end of at least one of the side openings being located more proximal than the distal end of the abutment surface of the proximal body, the elongated portion extending proximally from the base member, the proximal tip of the elongated portion being located further in the proximal direction than the proximal end of the abutment surface;
wherein, in the closed position, the elastomeric collar of the seal member contacts the abutment surface of the body member, thereby limiting proximal axial movement of the seal member, but not distal axial movement of the seal member, such that the proximal end of the seal member is at or near the proximal opening of the body member in the closed position; and wherein, in the open position, the elastomeric collar is separated from the abutment surface and the proximal opening of the proximal body member and the one or more side openings of the elongated portion are sized and positioned to permit the male luer tip of the medical implement to be advanced into the proximal body member a sufficient distance to permit the one or more side openings of the elongated portion to be positioned inside of the male luer tip of the medical implement and outside of the interior region of the seal member after the proximal tip of the elongated portion penetrates the proximal end of the seal member such that the proximal end of the seal member is distal from the proximal tip of the elongated portion and fluid in the medical implement is permitted to pass directly from within the male luer tip to the interior of the fluid passageway of the elongated portion without passing through the seal member.

US Pat. No. 10,391,292

HEMOSTASIS SEALING DEVICE WITH CONSTRICTION RING

Surmodics, Inc., Eden Pr...

1. A device for vascular access hemostasis, the device comprising:an enclosure configured to at least partially receive a medical device, the enclosure defining a cavity and having
a distal end;
a proximal end;
a first seal portion;
a second seal portion, the cavity disposed between the first seal portion and the second seal portion; and
a plurality of support ribs operably connected to the second seal portion;
a barrel in structural communication with the second seal portion; and
a constriction ring disposed around the barrel, the constriction ring interfacing with the second seal portion to limit movement of the second seal portion;
wherein the constriction ring is disposed around the barrel between the support ribs and the distal end.

US Pat. No. 10,391,288

IMPLANTABLE DEVICE FOR LONG-TERM DELIVERY OF DRUGS

Delpor, Inc., Brisbane, ...

1. A method for delivering a sparingly water soluble drug into an environment of use, comprising:providing a device comprising a porous partition with pores having a pore size and with a porosity, a reservoir and a formulation contained in the reservoir, the formulation comprising a sparingly water soluble drug having a soluble form and an insoluble form and a solubility-modifying excipient that generates acidic groups for a period of between about 2-12 months to provide, when the formulation is hydrated, a concentration of drug in the soluble form that is released across the porous partition and a concentration of drug in the insoluble form that is retained by the porous partition, and
delivering a therapeutic dose of the drug for the period, wherein delivering the therapeutic dose is dependent on pH of the drug formulation and independent of pore size of the porous partition with said porosity.

US Pat. No. 10,391,280

EXPANDABLE SHEATH

Edwards Lifesciences Corp...

1. A method of inserting an implant into a blood vessel of a patient, the method comprising:inserting a sheath at least partially into the blood vessel of the patient, the sheath comprising:
an expandable outer member including a lumen extending therethrough,
an inner member extending longitudinally within the lumen of the outer member, the inner member defining a central lumen of the sheath and including a folded portion comprising one or more folds, each of the one or more folds comprising portions of the inner member arranged in an overlapping configuration that moves to a less overlapping configuration when the inner and the outer members are expanded, thereby increasing a diameter of the central lumen of the sheath to allow passage of the implant therethrough;
a second folded portion circumferentially spaced around the inner member from the folded portion;
a third folded portion circumferentially spaced around the inner member from the folded portion and the second folded portion, wherein the folded portion, second folded portion and third folded portion are equally spaced circumferentially around the inner member; and
at least two reinforcing members extending longitudinally along a length of the sheath and located radially outward of the folded portion and the second folded portion;
advancing the implant through the central lumen of the inner member into the blood vessel;
expanding the inner and the outer members using an outwardly directed radial force of the implant, where expansion of the inner member causes a circumferential distance between the at least two reinforcing members to increase from a first circumferential distance to a second circumferential distance.

US Pat. No. 10,391,276

CATHETER

ASAHI INTECC CO., LTD., ...

1. A catheter, comprising:a tubular body including an inner layer and an outer layer; and
a radiopaque marker disposed in the tubular body such that a first gap including an empty space is provided between a radially inner side of the radiopaque marker and an outer surface of the inner layer of the tubular body in a radial direction of the tubular body,
wherein the inner layer has a tubular form with a lumen, the outer layer covers the radiopaque marker and the inner layer, the radially inner side of the radiopaque marker, the outer surface of the inner layer, and the outer layer abut the empty space, and
the empty space is formed by the radiopaque marker, the inner layer, and the outer layer.

US Pat. No. 10,391,263

INJECTION DEVICE WITH RETAINING MEANS ACTUATED BY NEEDLE SHIELD

Becton Dickinson France, ...

1. An injection device, comprising:a container holding a fluid;
a housing receiving the container;
a first shield removably connectable to a portion of the container; and
a retaining element transitionable between a first position in which movement of the container relative to the housing is prevented and a second position in which distal movement of the container relative to the housing is allowed,
wherein, with the first shield connected to the container, a portion of the first shield forces the retaining element into the first position,
wherein, with the first shield removed from the container, the retaining element is in the second position, and
wherein, when the retaining element transitions from the first position to the second position, the retaining element moves in order to allow distal movement of the container relative to the housing.

US Pat. No. 10,391,257

APPARATUS AND KITS FOR FLUID INFUSION

410 Medical, Inc., Durha...

1. An infusion device, comprising:a tubing set including:
a valve body having a first end, a second end opposite to and axially aligned with the first end and in selective fluid communication with the first end, and an inlet projecting laterally from the valve body between the first end and the second end and in selective fluid communication with the second end,
a syringe having an axially extending syringe body with a first end and an opposite second end, and a plunger disposed in the syringe body and extending from the second end, the first end of the syringe coupled to the second end of the valve body with the syringe body axially aligned with the first end and the second end of the valve body, and
inlet tubing having a first end coupled to the inlet of the valve and a second end coupleable to a source of liquid; and
a housing sized and configured to receive the syringe and the valve body, the housing having an upper surface defining a first receiving aperture and a second receiving aperture, the first receiving aperture configured to receive at least one of the inlet of the valve body or the inlet tubing such that the inlet is at least partially disposed within the first receiving aperture and such that the inlet extends laterally from the housing, the second receiving aperture configured to receive the first end of the valve body such that the first end extends axially from the housing; and
a lid defining a first receiving aperture and a second receiving aperture, the lid coupled to the housing and configured to transition relative to the housing between an open position and a closed position, the first receiving aperture of the lid configured to cooperate with the first receiving aperture of the housing to retain the at least one of the inlet tubing or the inlet of the valve body between the lid and the housing and the second receiving aperture of the lid configured to cooperate with the second receiving aperture of the housing to retain the first end of the valve body between the lid and the housing when the lid is in the closed position.

US Pat. No. 10,391,254

INNER HOUSING FOR A DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A dose setting mechanism for a drug delivery device, said dose setting mechanism comprising:an outer housing;
an inner housing having an external groove, the inner housing having an inner surface comprising a mechanical configuration;
a driver;
a dial sleeve disposed between said outer housing and said inner housing, said dial sleeve being rotatably engaged with said external groove of said inner housing; and
a dose dial grip rotatably coupled to said dial sleeve, said dose dial grip being non-rotatably coupled to a dose button,
wherein, when a dose is set by rotating said dose dial grip of said dose setting mechanism, said dial sleeve and said driver are both rotated with respect to both said outer housing and said inner housing and said dial sleeve and said driver are both translated away from both said outer housing and said inner housing, and
wherein the mechanical configuration of the inner surface of the inner housing is configured to prevent rotation of said driver relative to said inner housing during dispensing of said dose set by said dose setting mechanism to guide said driver to dispense said dose.

US Pat. No. 10,391,252

SUPPLEMENTAL DEVICE FOR ATTACHMENT TO AN INJECTION DEVICE

Sanofi-Aventis Deutschlan...

1. A supplemental device for releasable attachment to an injection device,the supplemental device comprising:
a housing;
an electromechanical switch arrangement coupled to the housing and having an open state and a closed state, the electromechanical switch arrangement comprising a protrusion configured to contact a surface of the injection device while the supplemental device is attached to the injection device;
a dose dialled detector operable to detect a dose of medicament dialled into the attached injection device;
a processor arrangement configured to:
monitor the detected dose of medicament dialled into the attached injection device;
determine a mode of operation of the injection device, wherein the injection device is operable in a plurality of modes of operation including a first mode of operation during which the detected dose is decreasing and no change in the state of the electromechanical switch arrangement is initially detected followed by detection of a change in the state of the electromechanical switch arrangement as the detected dose reaches zero; and
change a display output of the supplemental device when the processor determines that the injection device switches to the first mode of operation;
wherein the processor is configured to change the display output of the supplemental device from a dose delivery display to a dispense-end display when the processor determines that the injection device switches to the mode of operation;
a first spring configured to bias the electromechanical switch arrangement against the injection device such that the protrusion maintains contact with the surface of the injection device; and
a second spring disposed within the electromechanical switch arrangement and configured to bias the electromechanical switch arrangement in the open state.

US Pat. No. 10,391,237

ACTUATOR AND ACTUATION METHOD

CELLNOVO LIMITED, Swanse...

1. An actuator, comprising:a cavity containing a working medium that reversibly expands as it undergoes a phase change from a solid to a liquid state;
a diaphragm disposed adjacent the cavity such that expansion and contraction of the expandable working medium causes the diaphragm to deflect;
a semiconductor element disposed in the cavity, wherein the semiconductor element is operable in a first mode to heat the working medium to cause it to undergo the phase change into the liquid state, and is operable in a second mode to measure the temperature at the semiconductor element, wherein in the first mode, a first constant current is applied across the semiconductor element to heat the working medium, and in the second mode, a second constant current lower than the first constant current is applied across the semiconductor element, a voltage drop across the semiconductor element is measured, and the voltage drop is used to infer the temperature at the semiconductor element.

US Pat. No. 10,391,232

CANNULA INGRESS SYSTEM

KATALYST SURGICAL, LLC, ...

1. An instrument comprising:a hypodermic tube having a hypodermic tube distal end and a hypodermic tube proximal end wherein the hypodermic tube has dimensions configured for performing ophthalmic surgery;
a tip having a tip distal end and a tip proximal end wherein the tip proximal end is disposed in the hypodermic tube and wherein the tip distal end extends out from the hypodermic tube distal end;
a tip stabilization mechanism having a tip stabilization mechanism distal end, a tip stabilization mechanism proximal end, a tip stabilization mechanism outer diameter, a channel, and a tip stabilization mechanism inner diameter wherein the tip stabilization mechanism inner diameter is configured to prevent the tip from deforming when the tip is inserted into a valved cannula; and
a fixation mechanism configured to contact a segment of the hypodermic tube through the channel of the tip stabilization mechanism with a static friction force to temporarily fix the tip stabilization mechanism in a position relative to the hypodermic tube.

US Pat. No. 10,391,227

MEDICO-TECHNICAL MEASURING DEVICE AND MEASURING METHOD

Novalung GmbH, Heilbronn...

1. A medico-technical measuring device for measuring a pressure of blood, comprising:a flexible and pliable hose line which extends along a central longitudinal axis and is configured to guide blood within a longitudinal cavity delimited by a wall, the wall having an external sleeve surface and an internal sleeve surface; and
a sensor unit having a radial section with a sensor in the radial section, the sensor configured to measure the pressure of the blood guided in the longitudinal cavity;
wherein the hose line has a radial cavity defined in the wall in a radial direction, the radial cavity extending through the wall from the internal sleeve surface to the external sleeve surface;
the radial section of the sensor unit being at least partially arranged in the radial cavity in a radial position between the external sleeve surface and the internal sleeve surface of the wall and is integrated in the wall, such that the sensor is in communication with the blood;
wherein a diameter or an extent of a cross section of the radial cavity is smaller than the radial section that is at least partially arranged in the radial cavity such that the radial section of the sensor unit forms an oversize fit to which the radial cavity in the wall is sealed in a fluid-tight manner.

US Pat. No. 10,391,220

VIRTUAL KIDNEY DONATION

FRESNIUS MEDICAL CARE HOL...

1. A system comprising:a dialyzer having a blood side and a dialysate side;
a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the dialyzer to the vascular system of a kidney patient;
a second extracorporeal circuit including one or more second fluid connectors for connecting the dialysate side of the dialyzer to the vascular system of a healthy animal;
a first pump in fluid communication with at least one of the first and second extracorporeal circuits; and
a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source.

US Pat. No. 10,391,216

SUPPORTING A HEART

AdjuCor GmbH, Munich (DE...

1. A heart support system comprising:a heart-shaped cup comprising
a self-expanding sheath sized to fit about at least a portion of a heart in a living body, the self-expanding sheath having an internal contour that corresponds to an outer contour of the heart,
a plurality of expandable chambers each disposed at least in part on the self-expanding sheath so as to apply pressure against the heart when expanded, and
at least one sensor to be held in contact with a surface of the heart;
a conduit comprising
at least one pressurized fluid line for communicating pressurized fluid to the plurality of expandable chambers, and
at least one electrical connection port for communicating signals from the at least one sensor;
a supply unit comprising
a fluid reservoir for delivering the pressurized fluid to the plurality of expandable chambers,
processing circuitry for receiving signals from the at least one sensor, and
a supply unit connector for connecting the conduit to the supply unit;
wherein the conduit fluidically and electrically connects the heart-shaped cup to the supply unit such that all inputs and outputs to the heart-shaped cup are communicated via the conduit; and
wherein, in an expanded state, the heart-shaped cup has an internal contour that corresponds to an outer contour of the living heart such that a gap between the outer contour and the internal contour is at all points less than 8 mm.

US Pat. No. 10,391,207

IRRIGATION FLUID CONTAINMENT SYSTEMS

Dilip Tapadiya, M.D., Inc...

1. A medical basin for collecting fluid during an irrigation procedure of a wound on a human extremity, the medical basin comprising:a base on which the medical basin is configured to rest;
a peripheral wall connected to the base, the peripheral wall and the base together bounding a cavity that is configured to receive irrigation fluid during the irrigation procedure, wherein the peripheral wall comprises:
an interior surface;
an exterior surface comprising a top end and a bottom end, the exterior surface being inclined such that the bottom end of the exterior surface is closer to a center of the medical basin than the top end of the exterior surface when the medical basin is resting on the base;
a first side and a second side, wherein the first side and second side are opposed to each other, the first side including a first recess configured to receive the extremity and the second side including a second recess configured to receive the extremity, wherein the first recess is deflectable and biased laterally outwardly away from the cavity; and
a third side and a fourth side, wherein the third side and fourth side are opposed to each other; and
a clip configured to couple to the peripheral wall of the medical basin, the clip configured to engage and disengage with a suction hose to hold the hose in place relative to the peripheral wall to facilitate draining of irrigation fluid from the cavity.

US Pat. No. 10,391,189

PRE-DOFFING DISINFECTION SYSTEMS AND METHODS

Xenex Disinfection Servic...

2. The system of claim 1, wherein the program instructions for determining the operating parameters of the disinfection apparatus are further based on information regarding a target microorganism suspected of contaminating clothing and/or personal protective equipment worn by the individual.

US Pat. No. 10,391,188

DECONTAMINATION DEVICE AND METHOD USING ULTRASONIC CAVITATION

TOMI ENVIRONMENTAL SOLUTI...

1. A method for decontaminating an article or substantially enclosed space, comprising the steps of:shearing a cleaning fluid into a mist at substantially one atmosphere ambient pressure comprising aerosol droplets accumulating in a top chamber portion of a substantially closed chamber comprising a funnel shaped top chamber portion, a bottom chamber portion, a side chamber portion and an interior chamber portion, wherein the cleaning fluid is sheared by ultrasonic cavitation, wherein the cleaning fluid comprises a source of an active species for decontamination of an article or substantially enclosed space, wherein the active species is hydroxyl ions and wherein the source is hydrogen peroxide and the cleaning fluid is silver-free chlorine-free and peracetic-acid free;
subjecting the mist to a nonthermal plasma actuator to form plasma activated ionic particles carried by the aerosol droplets of the mist, wherein the plasma activated ionic particles are hydroxyl ions;
dispersing the mist by high voltage actuation; and
contacting the article or substantially enclosed space to the plasma activated ionic particles.

US Pat. No. 10,391,182

BIFUNCTIONAL CYTOTOXIC AGENTS

Pfizer Inc., New York, N...

1. A compound of Formula (IIA):L-P  (IIA)
or a pharmaceutically acceptable salt or solvate thereof, wherein:
P is:
F1-L1-T-L2-F2  (I)
or a pharmaceutically acceptable salt or solvate thereof, wherein:
F1 and F2 are each independently selected from ring systems A, and B:

wherein:
each V1 is independently a bond, O, N(R) or S, for each ring system A in which V1 appears;
each V2 is independently O, N(R) or S, for each ring system B in which V2 appears;
W1 and W2 are each independently H, —C1-C5 alkyl or -phenyl, for each ring system A and ring system B in which W1 and W2 appear;
each X is independently —OH, —O-acyl, azido, halo, cyanate, thiocyanate, isocyanate, thioisocyanate, or
for each ring system A in which X appears;each Y is independently selected from a bond, H, —C(O)RA, —C(S)RA, —C(O)ORA, —S(O)2ORA, —C(O)N(RA)2, —C(S)N(RA)2, glycosyl, —NO2 and —P(O)(ORA)2 for each ring system in which Y appears, wherein each RA is independently selected from H, —C1-C20 alkyl, —C1-C8 heteroalkyl, —C6-C14 aryl, aralkyl, —C1-C10 heterocyclyl, —C3-C8 carbocyclyl, —C1-C20 alkylN(R)2, —C1-C20 alkylene, —C1-C8 heteroalkylene, —C6-C14 arylene, aralkylene, —C1-C10 heterocyclo, —C3-C8 carbocyclo and —C1-C20 alkylN(R)—, and RF where said RA is optionally substituted with 1 to 3 substituents independently selected from R, and wherein one Y is divalent and is bonded to L,
RF is —N(R6)QN(R5)C(O)— and is bonded to L at the carbonyl adjacent N(R5), wherein R5 and R6 are each independently selected from the group consisting of H, —C1-C8 alkyl, —C1-C8 heteroalkyl, —C6-C14 aryl, -aralkyl, —C1-C10 heterocyclyl and —C3-C8 carbocyclyl, or R5 or R6 joins with a substituted carbon on Q to form a —C1-C10 heterocyclic or —C6-C14 heteroaryl ring, or R5 and R6 join together to form a —C1-C10 heterocyclic or —C6-C14 heteroaryl ring system, and where Q is —C1-C8 alkylene-, —C1-C8 heteroalkylene-, —C6-C14 arylene-, -aralkylene-, —C1-C10 heterocyclo- or —C3-C8 carbocyclo-, wherein Q, R5 and R6 are each independently optionally substituted with 1 to 3 substituents independently selected from R;
each Z is independently selected from the group consisting of H, —C1-C8 alkyl, —C1-C8 heteroalkyl, —C6-C14 aryl, -aralkyl, —C1-C10 heterocyclyl and —C3-C8 carbocyclyl, and wherein said C1-C8 alkyl, —C1-C8 heteroalkyl, —C6-C14 aryl, -aralkyl, —C1-C10 heterocyclyl and —C3-C8 carbocyclyl, are each optionally substituted with 1 to 3 substitutents independently selected from R, for each ring system A and ring system B in which Z appears;
L1 and L2 are each independently a direct bond;
T is selected from:
—C(A1)X1-T2-X1C(B1)—, where T2 is:

wherein each X1 is independently a bond, —NRE—, —O— or —S—, wherein A1 and B1 are each independently ?O or ?S,
wherein R1, R2, R3, and R4 are each independently RE, or R1 and R2 form a ring system, or R3 and R4 form a ring system, or both R1 and R2, and R3 and R4, each independently form ring systems, or R1 and R3 form a ring system, or R2 and R4 form a ring system, or both R1 and R3, and R2 and R4, each independently form ring systems, where said ring systems are independently selected from —C3-C8 carbocyclycl, or R1, R2, R3 and R4 are each bonds to different carbons on D, wherein g and j are each independently an integer from 0 to 50 and m is an integer from 1 to 50, and wherein D is —C3-C8 carbocyclo optionally substituted with —RE, —C(O)RE, —C(O)ORE, —N(RE)2, —N(R)C(O)RE or —N(R)C(O)ORE, and D is additionally optionally substituted by 1 to 2 R, and
wherein each RE is independently selected from the group consisting of H, —C1-C8 alkyl, —C1-C8 heteroalkyl, —C6-C14 aryl, -aralkyl, —C1-C10 heterocyclyl, —C3-C8 carbocyclyl, —C(O)OC1-C8 alkyl, —C(O)N(C1-C8 alkyl)2, and —C(O)-halo, and wherein each RE is optionally substituted with 1 to 3 substitutents independently selected from R,
and wherein each R is independently selected from the group consisting of H, —C1-C20 alkyl, —C2-C6 alkenyl, —C2-C6 alkynyl, halo, hydroxyl, alkoxy, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —NO2, —C6-C14 aryl and —C6-C14 heteroaryl, wherein two or more R optionally join to form a ring or rings, and wherein said —C6-C14 aryl and —C6-C14 heteroaryl are optionally substituted with 1 to 5 substituents independently selected from —C1-C10 alkyl, —C1-C10 alkoxy, -halo, —C1-C10 alkylthio, -trifluoromethyl, —NH2, —NH(C1-C8 alkyl), —N(C1-C8 alkyl)2, —C1-C10 alkyl-N(C1-C8 alkyl)2, —C1-C3 alkylthio, —NO2 or —C1-C10 heterocyclyl, for each ring system in which R appears;
L is LA-LB-(LC)1-3, wherein LA is selected from the group consisting of -halo, —N(R)2, —CON(R)2, —S-aryl optionally substituted with —NO2 or —CON(R)2, —S-heteroaryl optionally substituted with —NO2, alkyl-SO2-heteroaryl, arylSO2-heteroaryl-,

LB is LB1-LB2-LB3 wherein LB1 is absent or is one or more components selected from the group consisting of —C(O)—, —C(S)—, —C(O)NR—, —C(O)C1-C6alkyl-, —C(O)NRC1-C6alkyl-, —C1-C6alkyl(OCH2CH2)1-6—, —C(O)C1-C6alkylNRC(O)—, —C(O)C1-C6alkyl(OCH2CH2)1-6—, —C1-C6alkyl(OCH2CH2)1-6—C(O)—, —C1-C6alkyl-S—S—C1-C6alkylNRC(O)CH2—, —C1-C6alkyl(OCH2CH2)1-6NRC(O)CH2—, —C(O)C1-C6alkyl-NRC(O)C1-6alkyl-, —N?CR-phenyl-O—C1-C6alkyl-, —N?CR-phenyl-O—C1-C6alkyl-C(O)—, —C(O)—C1-C6alkyl(OCH2CH2)1-6NRC(O)—, —C(O)C1-C6alkyl-phenyl(NR—C(O)C1-C6alkyl)1-4-, —C(O)C1-C6alkyl(OCH2CH2)1-6—NRC(O)C1-C6alkyl-, —C1-C6alkyl-, —S—, —C(O)—CH(NR—C(O)C1-C6alkyl)-C1-C6alkyl- and (—CH2—CH2—O—)1-20,
wherein LB2 is AA0-12, wherein AA is a natural amino acid, a non-natural amino acid or —(CR15)o—S—S—(CR15)p where o and p are each independently an integer from 1 to 20,
LB3 is -PABA-, -PABC- or absent;
LC is absent or independently selected from the group consisting of —C1-C6alkylene-, —NRC3-C8-heterocyclylNR—, —NRC3-C8-carbocyclylNR—, —NRC1-C6alkylNR—, —NRC1-C6alkylene-, —S—, —NR—, —NRNR—, —O(CR2)1-4S—S(CR2)1-4N(R)—, —NRC1-C6-alkylenephenyleneNR—, —NRC1-C6alkylenephenyleneSO2NR—, —OC1-C6alkylS-SC1-C6alkylC(COOR)NR—, —NRC(COOR)C1-C6alkylS-SC1-C6alkylO—,

wherein
XA is CR or N,
XB is CH, CR(C(R)2)1-3NR, CR(C(R)2)1-3O, CR(C(R)2)1-3C(O)NR, CR—(C(R)2)1-3C(O)NRNR, CR(C(R)2)1-3SO2NR, CR(C(R)2)1-3NRNR, CR(C(R)2)1-3NRC(O) or N,
each XC is R,
each XD is —(CH2)1-5—, or is absent;
XE is O, S, C(R)2, C(R)(C(R)2)1-3—NR2 or NR and
each XF is (C(R)2)1-3—NR or C(R)2—(C(R)2)1-3—O.

US Pat. No. 10,391,174

METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF

NANOBIOTIX, Paris (FR)

1. A method for inducing in vitro, ex vivo or in vivo the perturbation, lysis or destruction of target human cells selected from the group consisting of benign cells, pre-malignant cells and malignant cells, comprising i) contacting said target cells with a population of metallic nanoparticles during a period of time sufficient to allow the nanoparticles to interact with said cells, each nanoparticle of the population being made of a metal having an atomic number (Z) of at least 25, each metallic nanoparticle of the population being covered with a biocompatible coating, and the mean largest size of the nanoparticles of the population being between 80 and 105 nm, and, ii) exposing the cells to ionizing electromagnetic radiation, said exposure inducing or causing the perturbation, lysis or destruction of said cells.

US Pat. No. 10,391,141

COMPOSITION COMPRISING HYDROLYSED PROTEINS AND OLIGOSACCHARIDES FOR TREATING SKIN DISEASES

Societe des Produits Nest...

1. A method for treatment of atopic dermatitis by promoting metabolic activity and growth of lactic acid bacteria comprising Bifidobacterium longum subsp. infantis, the method comprising administering orally to an individual in need of same an effective amount of a composition consisting of carbohydrates, proteins comprising hydrolysed proteins in which 15% to 95% of the hydrolysed proteins have a molecular weight less than 1,000 Dalton, lipids, minerals, and vitamins, the carbohydrates comprising oligosaccharides consisting of (i) lacto-N-tetraose, 3?-sialyllactose, 6?-sialyllactose, 2?-fucosyllactose, and difucosyllactose, and the lacto-N-tetraose, the 3?-sialyllactose, the 6?-sialyllactose, the 2?-fucosyllactose, and the difucosyllactose are the only human oligosaccharides in the composition; or (ii) lacto-N-tetraose, lacto-N-neotetraose, 3?-sialyllactose, 6?-sialyllactose, 2?-fucosyllactose, and difucosyllactose, and the lacto-N-tetraose, the lacto-N-neotetraose, the 3?-sialyllactose, the 6?-sialyllactose, the 2?-fucosyllactose, and the difucosyllactose are the only human oligosaccharides in the composition, the individual is an infant with a food allergy or a young child with a food allergy.

US Pat. No. 10,391,120

METHODS OF USING INHALED NITRIC OXIDE GAS FOR TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN CHILDREN

Mallinckrodt Hospital Pro...

1. A method of treating acute respiratory distress syndrome (ARDS) in children comprising administering a gas comprising nitric oxide (NO) to a child in need thereof at a dose in the range from about 2 ppm to about 8 ppm NO for a treatment period of at least 24 hours, wherein the child is determined to have an oxygenation index of greater than or equal to 12 cm H2O/mmHg.

US Pat. No. 10,391,119

LACRIMAL OILY LAYER STABILIZER AND EYE DROPS COMPRISING SAME

NOF Corporation, Tokyo (...

1. A method of effecting tear lipid layer stabilization on a corneal surface of a mammal:administering, to a mammal, a tear lipid layer stabilizer containing a copolymer that has a weight-average molecular weight of from 10,000 to 5,000,000, and contains 10 mol % to 90 mol % of a constituent unit (A) based on 2-(meth)acryloyloxyethyl phosphorylcholine and 90 mol % to 10 mol % of a constituent unit (B) based on an alkyl group-containing (meth)acrylic monomer, or an ophthalmic solution containing the stabilizer:

R1 represents a hydrogen atom or a methyl group; and

R2 represents a hydrogen atom or a methyl group, and R3 represents an alkyl group having 4 to 18 carbon atoms in an amount effective to reduce evaporation of a tear aqueous layer, wherein the ophthalmic solution does not contain hydroxypropyl methylcellulose.

US Pat. No. 10,391,118

PROTON-BINDING POLYMERS FOR ORAL ADMINISTRATION

TRICIDA, INC, South San ...

1. A method of treating metabolic acidosis in an animal, the method comprising oral administration to the animal of a pharmaceutical composition comprising a proton-binding, crosslinked amine polymer comprising the residue of an amine corresponding to Formula 2:whereinm and n are independently non-negative integers;
R10, R20, R30, and R40 are independently hydrogen, hydrocarbyl, or substituted hydrocarbyl;
X1 is

X2 is hydrocarbyl or substituted hydrocarbyl;
each X11 is independently hydrogen, hydrocarbyl, substituted hydrocarbyl, hydroxy, or amino;
z is a non-negative number;
the crosslinked amine polymer has an equilibrium swelling ratio in deionized water of 2 or less; and
the crosslinked amine polymer binds a molar ratio of chloride ions to interfering ions of at least 0.35:1, respectively, in an interfering ion buffer at 37° C. wherein the interfering ions are phosphate ions and the interfering ion buffer is a buffered solution at pH 5.5 of 36 mM chloride and 20 mM phosphate.

US Pat. No. 10,391,092

METHODS FOR TREATING CANCER USING DIHYDROPYRAZINO-PYRAZINE COMPOUND COMBINATION THERAPY

Signal Pharmaceuticals, L...

1. A method for achieving complete response, partial response or stable disease, as determined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1), in a patient having castration-resistant prostate cancer, comprising administering to a patient having castration-resistant prostate cancer an effective amount of a Dihydropyrazino-Pyrazine Compound in combination with an effective amount of MDV3100, wherein the Dihydropyrazino-Pyrazine Compound is a compound having the structure:
or a pharmaceutically acceptable salt, clathrate, solvate, stereoisomer, tautomer or isotopologue thereof.

US Pat. No. 10,391,091

METHOD OF MANUFACTURING BUPRENORPHINE AND ANALOGUES THEREOF FROM ORIPAVINE

Siegfried AG, Zofingen (...

1. A method of preparing a compound of Formula II, or a salt thereof, from a compound of Formula I, wherein in Formula II, R? represents a linear, branched and/or cyclic alkyl group having 1 to 10 carbon atoms, R? represents a linear or branched alkyl group having 1 to 10 carbon atoms, and R?? represents H or CH3, comprising:
(i) optionally replacing the group R in the compound of Formula I, wherein R is H or methyl, by a group R? being a linear, branched and/or cyclic alkyl group having 1 to 10 carbon atoms;
(ii) adding methyl vinyl ketone to obtain 1-[(5?,7?)-17-alkyl-4,5-epoxy-3-hydroxy-6-methoxy-6,14-ethenomorphinan-7-yl]ethanone or 1-[(5?,7?)-17-alkyl-4,5-epoxy-3-alkoxy-6-methoxy-6,14-ethenomorphinan-7-yl]ethanone;
(iii-a) converting the acetyl group in position 7 into a tertiary alkyl alcohol having a general structure —C—(OH)—(CH3)-R?, wherein R? represents a linear or branched alkyl group with 1 to 10 carbon atoms; and
(iv-a) reducing the etheno group in position 18,19 to form the compound of Formula II; and
(v) optionally converting the product from step (iv-a) into an addition salt, preferably a pharmaceutically acceptable salt,
wherein the protection of a side chain is avoided.

US Pat. No. 10,391,088

ANALGESIC COMPOSITIONS

Lohocla Research Corporat...

1. A pharmaceutical composition comprising an aminoquinoline compound of Formula
in free acid form, free base form, or as a pharmacologically acceptable addition salt wherein:
R7 is alkyl (preferably a 3 to 6 carbon alky), or phenyl;
R8 is alkyl (preferably a 3 to 6 carbon alkyl), or phenyl;
E1 is —C(?O)R9;
each R9 is H or C1-C4 alkyl;
each X2 and X3 independently is an electron withdrawing group (preferably halogen or nitro);
together with an analgesic agent different from the aminoquinoline compound and selected from the group consisting of a NSAID, an opioid, a NE/5-HT reuptake inhibitor, and mixtures thereof.

US Pat. No. 10,391,083

TRIAZOLONE COMPOUNDS AS MPGES-1 INHIBITORS

GLENMARK PHARMACEUTICALS ...

1. A process for preparing a compound of formulaor a pharmaceutically acceptable salt thereof, the process comprising:Step 1: reacting a compound of the formula

 with a compound of the formula

 to obtain a compound of the formula

Step 2: converting the compound of formula

 and
Step 3: converting the compound of formula

US Pat. No. 10,391,066

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON'S DISEASE

Texas Tech University Sys...

1. A composition for treating, alleviating or delaying progression of the symptoms of Parkinson's Disease comprising:a pharmaceutical carrier containing
an amount effective to ameliorate at least one symptom of Parkinson's Disease of one or more compositions having the formula

US Pat. No. 10,391,058

PHARMACEUTICAL COMPOSITION COMBINING AT LEAST TWO DISTINCT NANOPARTICLES AND A PHARMACEUTICAL COMPOUND, PREPARATION AND USES THEREOF

NANOBIOTIX, Paris (FR)

1. A method for treating cancer comprising a step of administering at least one pharmaceutical anti-cancer compound to a subject in need thereof and a distinct step of administering at least two distinct biocompatible lipid-based nanoparticles to said subject, wherein the longest dimension of each of the at least two biocompatible nanoparticles is between about 4 nm and about 500 nm, the surface charge value of a first biocompatible nanoparticle is a negative charge below ?10 mV, the surface charge value of a second biocompatible nanoparticle, or of any additional biocompatible nanoparticle, is negative and has a difference of at least 10 mV to the negative surface charge value of the first biocompatible nanoparticle, each of the at least two biocompatible nanoparticles is not used as the at least, one pharmaceutical compound, and said at least two distinct biocompatible nanoparticles are administered to the subject separately from the at least one pharmaceutical compound between 4 hours and about 24 hours before said at least one pharmaceutical compound.

US Pat. No. 10,391,031

ADAPTER FOR VIAL ACCESS DEVICE

Becton Diskinson and Comp...

1. A system selectively attachable to a first vial defining a first vial size and a second vial defining a second vial size, the second vial size different than the first vial size, the system comprising:a vial access device including a spike, the vial access device directly attachable to the first vial, the vial access device having a first connection element attachable to the first vial to secure the vial access device to the first vial; and
an adapter movable relative to the vial access device between a shield position in which the adapter is attachable to the vial access device such that the adapter shields the spike of the vial access device and a vial position in which the adapter is attachable to the second vial.

US Pat. No. 10,391,021

MASSAGE HEAD AND MASSAGE APPARATUS USING SUCH A HEAD

LPG Systems, Valence (FR...

1. A massage head comprising a casing defining an internal chamber configured to have a skinfold formed therein when the massage head is applied to a patient's skin, said fold configured to come into contact with the lower edges of the chamber, said chamber being defined by two lateral walls and by two transverse walls, at least one of said transverse walls being formed of a flap capable of having a pivoting motion, to induce the coming closer and the drawing away from each other of the lower edges of said transverse walls configured to be in contact with the skinfold:wherein said at least one flap is hinged in the vicinity of its upper end on the lateral walls; and
wherein the pivoting of the flap is obtained by means of a geared motor fixedly assembled within said flap, an output shaft of said geared-motor rotating a cam, received in a cam race rigidly attached to one of the lateral walls of the internal chamber.

US Pat. No. 10,391,020

ARM THERAPY DEVICE

Bymers and Johnson Therap...

1. An arm therapy device, comprising:a housing comprising an upper end, a lower end, a first side, a second side, and an upper opening;
a first slot extending across the first side of the housing;
a second slot extending across the second side of the housing;
a first roller movably positioned within the first slot and the second slot such that the first roller extends between the first side and the second side of the housing;
a first collar connected to the first roller, the first collar being positioned externally with respect to the housing, wherein the first collar comprises a first threaded connector, the first threaded connector being threadably and removably connected to the first roller;
a second roller movably positioned within the first slot and the second slot such that the second roller extends between the first side and the second side of the housing;
a second collar connected to the second roller, the second collar being positioned externally with respect to the housing, wherein the second collar comprises a second threaded connector, the second threaded connector being threadably and removably connected to the second roller; and
a bias member connected between the first collar and the second roller collar such that the first roller and the second roller are each biased toward each other.

US Pat. No. 10,391,012

SYSTEM, METHOD, AND COMPUTER ALGORITHM AND CHARACTERIZATION AND CLASSIFICATION OF ELECTROPHYSIOLOGICAL EVOKED POTENTIALS

SafeOp Surgical Inc., St...

1. When somatosensory EP waveforms are acquired, a method of automatically identifying potential injury to peripheral nerve structures comprising:causing, by an automated EP analysis apparatus with an electrical pulse via electrodes, stimulation of a peripheral nerve structure, the automated EP analysis apparatus having a processor and memory;
recording, by the automated EP analysis apparatus via electrodes placed at the neck or head, signals forming a resultant electrical (EP) waveform generated by the nervous system;
measuring, by the automated EP analysis apparatus, a change in the recorded EP waveform relative to a baseline response, the change comprising Euclidean distance between the recorded EP waveform and the baseline response;
comparing, by the automated EP analysis apparatus, the change with one or more threshold change values to classify the recorded EP waveform; and
determining, by the automated EP analysis apparatus, whether a current state of the peripheral nerve structure has changed based on the classification of the recorded EP waveform by determining whether a count of EP waveforms in a classification exceeds a threshold count value.

US Pat. No. 10,391,011

ADJUSTABLE SUPPORT POLE HANDLE

Stander Inc., Logan, UT ...

1. A support pole, comprising:a support member comprising a longitudinal axis, a first support portion, and a second support portion, wherein the first support portion and the second support portion comprise an external groove that extends along the longitudinal axis and aligns when the support portions are assembled to inhibit rotational displacement of each support portion relative to each other;
a floor mount coupled to a first end of the support member;
a ceiling mount coupled to a second end opposite the first end of the support member;
a height adjustment component coupled to support member, wherein the height adjustment component is configured to adjust a length of the support member between the first end and the second end, wherein the height adjustment component is disposed between the first support portion and the second support portion, wherein the height adjustment component comprises a first threaded portion and a second threaded portion, wherein the first threaded portion is coupled to the first support portion and the second threaded portion is coupled to the second support portion; and
a handle coupled to the support member, wherein the handle is positionable 360 degrees about the support member and along the longitudinal axis between the first end and the second end.

US Pat. No. 10,390,991

MEDICAL DEVICES INCORPORATING THERMOELECTRIC TRANSDUCER AND CONTROLLER

SCION NEUROSTIM, LLC, Ra...

1. A temperature control system comprising:a thermoelectric device;
a controller electrically coupled to the thermoelectric device and configured to sense an electrical characteristic of the thermoelectric device;
a heat transfer structure thermally coupled to a first side of the thermoelectric device;
a temperature controlled medium thermally coupled to a second side of the thermoelectric device so that the thermoelectric device is thermally coupled between the heat transfer structure and the temperature controlled medium, wherein said temperature controlled medium comprises a medical instrument configured to contact living tissue; and
a temperature feedback sensor, wherein said controller is configured to generate a first electrical control signal to activate said thermoelectric device and said first electrical control signal is generated in response to a first value of the electrical characteristic of the thermoelectric device, wherein the electrical characteristic of the thermoelectric device comprises an electrical characteristic of the thermoelectric device indicating one of a temperature gradient across the thermoelectric device and a temperature of the temperature controlled medium.

US Pat. No. 10,390,971

CYLINDER HEAD, ELEMENT AND FLANGE OF A PISTON ENGINE

MECACHROME FRANCE, Amboi...

1. A longitudinal piston-engine cylinder head, comprising:a cylinder head body and a base plate, the base plate comprising at least one element that extends entirely within a plane, the base plate being interposed between a combustion chamber and the cylinder head body,
wherein the base plate comprising an upper face facing the cylinder head body and an opposing lower face arranged to face the combustion chamber, the base plate being attached to the cylinder head body, the cylinder head body being made of a material with mass density and hardness values that are lower than the mass density and hardness values of a material used to make the base plate,
wherein the base plate and the cylinder head body are assembled with screws used to fasten the base plate to the cylinder head body that are located towards the periphery of the base plate and of the cylinder head body and at least one part used to fasten the cylinder head body to the base plate comprising a threaded end engaged in a corresponding orifice of the base plate, said corresponding orifice being located closer to a center of the base plate than the screws,
wherein the base plate or each of at least one element of the base plate includes an internal cooling circuit to circulate a heat-transfer fluid, said internal cooling circuit having at least one fluid inlet, a fluid circulation channel and several fluid drainage channels, the several fluid drainage channels forming an angle greater than 20° with the plane of the base plate passing around gas exhaust ducts of the cylinder head body and wherein the fluid circulation channel, extending along a path, has an average width that is less than 20% of a transverse dimension of the base plate and includes, along said path, at least one narrowing of the path extending over at least 2.5% of a length of the path and an average width of at least one narrowing of the path parallel to the plane of the base plate is less than 10% of a width of the base plate.

US Pat. No. 10,390,956

DEVICE FOR COVERING AND/OR RECONSTRUCTING A BONE DEFECT SITE, METHOD FOR PRODUCING A CAP FOR A COVER FOR A BONE DEFECT SITE

ReOss GmbH, Filderstadt ...

1. Device for a bone defect site, the device comprising:a cap comprising a rim and a first side configured to face away from the bone defect and a second side configured to face toward the bone defect,
wherein the cap comprises a dimensionally stable material, and the second side of the cap or the first side of the cap is configured to correspond to the shape of a regenerated bone,
wherein
the device has at least one positioning portion having a continuous wall configured to face a healthy bone that borders on the bone defect, the at least one positioning portion being disposed at the rim of the cap,
or
the device has at least one connector for fixation of the cap within the region of the bone defect, and the device has at least one positioning portion having a wall configured to face a healthy bone that borders on the bone defect, the at least one positioning portion being disposed at the rim of the cap.

US Pat. No. 10,390,954

METHOD TO INTRODUCE AN IMPLANTABLE DEVICE TO FILL A BONE VOID WHILST MINIMISING PRESSURISATION

BIOCOMPOSITES LIMITED, K...

1. A method of reconstructing a bone void in a patient, the method comprising introducing into a bone void of one or more implantable devices, each of which one or more implantable devices are substantially cylindrical, having a convex, domed or semi-spherical shaped ends; contain one or more longitudinal channels where the one or more longitudinal channels create a venting path allowing for depressurisation of any contents of the bone void, the one or more longitudinal channels each intersecting a surface of the device and extending towards an axial centerline thereof, and being tapered such that the width of the one or more longitudinal channels opening on an outer, circumferential edge of the implantable device is greater than its width at a base thereof; and have a flat surface on an opposing longitudinal side to the one or more longitudinal channels;whereby introduction of the one or more implantable devices reconstructs bone in the bone void in the patient.

US Pat. No. 10,390,931

DEVICES AND METHODS FOR ANATOMIC MAPPING FOR PROSTHETIC IMPLANTS

Aortica Corporation, Bel...

1. A method, comprising:receiving a digital representation of a portion of a patient's blood vessel, the digital representation including data representative of a first location of an anatomic feature of the patient's blood vessel;
modifying the data representative of the first location based on predicted deformation of the portion of the patient's blood vessel to determine a second location of the anatomic feature of the patient's blood vessel, the second location different than the first location; and
generating a patient-specific prosthesis having a fenestration at the second location.

US Pat. No. 10,390,909

PROSTHESIS SYSTEM

DENTALPOINT AG, Zurich (...

1. A dental prosthesis system comprising: a ceramic implant for osseointegration in a jaw bone; a connection screw, wherein the ceramic implant comprises a receiving opening adapted to receive the connection screw; an abutment securable in the receiving opening of the implant (1) by the connection screw (7, 7?, 7?, 7??), wherein the connection screw is made of fibre reinforced thermoplastic; and a screw lock, which includes a first interlocking means and a second interlocking means, wherein the first interlocking means is arranged on the connection screw (7, 7?, 7?, 7??) and the second interlocking means arranged at the receiving opening of the implant, and when tightening or releasing the connection screw (7, 7?, 7?, 7??) in the implant, the first interlocking means is elastically deformable in conjunction with the second interlocking means; and wherein the first interlocking means is formed as a multi-edged outer profile on the connection screw (7, 7?, 7?, 7??) and the second interlocking means is formed as a multi-edged inner profile (13) in the receiving opening of the implant, wherein the multi-edged inner profile is preferably formed as a triangular profile.

US Pat. No. 10,390,905

SURGICAL GUIDING TOOL, METHOD AND KIT FOR PLACING DENTAL IMPLANTS

Drs. Bettens-De Pooter BV...

12. A method for guiding a drilling system, using a device suitable for the subsequent positioning of a pterygoid dental implant, comprising:a. a handle extending along a longitudinal axis and having a proximal and a distal end;
b. and a bifurcated abutment at the distal end and at the proximal end of the handle, each comprising two legs, whereby a first of the bifurcated abutment is adapted to encircle the left maxilla at the processus pyramidalis ossis palatini and/or the processus pterygoideus ossis sphenoidalis and/or the tuberosity of the left maxilla, and is adapted to fit over a relief in the bone structure at the sutura pterygomaxillaris of the left maxilla; and whereby a second of the bifurcated abutment is adapted to encircle the right maxilla at the processus pyramidalis ossis palatini and/or the processus pterygoideus ossis sphenoidalis and/or the tuberosity of the right maxilla, and is adapted to fit over a relief in the bone structure at the sutura pterygomaxillaris of the right maxilla; and
whereby the second leg of at least one abutment is generally straight or slightly bent;
said method comprising the following steps:
a. administering an anesthetic to a patient;
b. making an incision, between 4 to 20 mm long in the mucosa, muscles and periosteum down to the bone;
c. partially introducing the device in the mouth of a patient, so that the appropriate abutment is introduced in the mouth of the patient;
d. mounting the device onto the upper jaw of the patient;
e. positioning the device so that:
a. an angulation of the longitudinal axis of the handle relative to the Frankfort plane of the patient from a sagittal view is reached either comprised between 30° and 90°, either between 40° and 50° or 67.5° and 77.5°, or either about 45° or 72.5°;
b. and a buccopalatal angulation of the longitudinal axis of the handle relative to the Frankfort plane is reached comprised between 65° and 110° from a frontal view, or about 81.3°;
f. drilling into the upper jaw along the longitudinal axis of the handle;
wherein mounting the device onto the upper jaw of the patient is executed by encircling the processus pyramidalis ossis palatini and/or the tuberosity of the maxilla and/or the processus pterygoideus ossis sphenoidalis with the introduced abutment.

US Pat. No. 10,390,871

CRYONEEDLE

Galil Medical Inc., Arde...

1. A cryoneedle comprising:an outer tube having a distal section and a longitudinal axis;
a gas supply line positioned within the outer tube, the gas supply line configured to supply a cryogas for forming an ice ball on an outer surface of the outer tube over the distal section, the gas supply line having a cryogas outlet;
an expansion chamber located within the distal section such that the gas supply line terminates in the expansion chamber, the cryogas outlet being positioned in the expansion chamber;
an electrical resistance heater configured to heat tissue, when current is supplied thereto, the electrical resistance heater comprising a wire wound around the gas supply line into helical coils, the electrical resistance heater being located within the distal section of the outer tube;
a heat exchange helix contacting an inner surface of the outer tube, the heat exchange helix extending longitudinally in a distal direction past the cryogas outlet in the distal section; and
a return gas flow lumen defined annularly between the heat exchange helix and the gas supply line adapted to carry the cryogas from the expansion chamber along a return flow path,
the heat exchange helix adapted to provide generally uniform rate of heat transfer in the distal section such that the ice ball formed on the outer surface of the outer tube is generally symmetric in shape along the longitudinal axis of the outer tube.

US Pat. No. 10,390,864

INTERSPINOUS IMPLANT

Zimmer Biomet Spine, Inc....

1. An interspinous implant having a longitudinal superior-inferior axis, the interspinous implant comprising:a body having a medial-lateral width and an anterior-posterior depth;
a first bracket connected to the body and extending in the superior direction, the first bracket comprising a first pair of legs that define a first opening extending along a first bracket axis, the first bracket axis extending parallel to the longitudinal superior-inferior axis;
a second bracket connected to the body and extending in the inferior direction, the second bracket comprising a second pair of legs that define a second opening extending along a second bracket axis, the second bracket axis extending parallel to the longitudinal superior-inferior axis;
a first channel defined by the interspinous implant between the first pair of legs; and
a second channel defined by the interspinous implant between the second pair of legs, the first and second channels extend parallel to one another in an anterior-posterior direction and oblique to the longitudinal superior-inferior axis along at least portions of respective lengths thereof;
wherein the second pair of legs are spaced to directly engage a spinous process of a vertebra by having a spacing that approximates a width of the spinous process;
wherein the second bracket includes flanges extending laterally from the second pair of legs to directly engage a lamina of the vertebra adjacent the spinous process, the flanges having a length sufficient to support the lamina;
wherein the first bracket and the second bracket are offset in the anterior-posterior direction such that the first bracket axis and the second bracket axis are not coaxial; and
wherein the second pair of legs is configured to engage an anterior portion of the spinous process of the vertebra and the first pair of legs is configured to support a posterior portion of an additional spinous process of an additional vertebra superior of the vertebra engaged by the second pair of legs when the second bracket is engaged with the lamina of the vertebra adjacent the spinous process.

US Pat. No. 10,390,860

INTERNAL PEDICLE INSULATOR

CHAP-MED, INC., Destin, ...

1. A method for stabilizing a surgical fixture comprising:inserting an implant into tissue, the implant comprising:
a non-continuous cylindrical wall defining an interior cavity and having a first end and a second end;
a first segment of the cylindrical wall comprising a smooth exterior surface;
and
a second segment of the cylindrical wall comprising a rough exterior surface, wherein:
the first segment of the cylindrical wall is of a greater thickness than the second segment of the cylindrical wall; and
a portion of the second segment of the cylindrical wall overlaps a portion of the first segment of the cylindrical wall, extending into the interior cavity; and
driving a distal end of a fixture into tissue into which the implant is inserted.

US Pat. No. 10,390,830

SURGICAL CLIP APPLICATOR

Aesculap AG, (DE)

1. A surgical clip applicator comprising:an individual clip magazine being formed as a separate unit; and
a universal handgrip to which the individual clip magazine being arbitrarily selected from a number of different types of clip magazines, can be detachably mounted or fastened,
wherein the individual clip magazine comprises:
a crimping head or crimping tool at a distal end portion;
a clip receiving portion provided proximal to the crimping head or crimping tool;
a clip advancing device for conveying individual clips from the clip receiving portion via an individual feed path toward the crimping head or crimping tool;
a magazine-integrated coding comprising two limiting stops defining the individual feed path thereby limiting the clip advancing device in its conveying movement, which limiting stops are formed and positioned depending on the clip type to be applied; and
a proximal end portion on the individual clip magazine, the proximal end portion on the individual clip magazine being adapted to detachably lock or arrest the individual clip magazine in the universal hand grip, and
wherein the universal handgrip comprises:
an integrated force transmission gearing comprising:
at least one manually graspable handle as an actuation-/input part; and
a coupling element as an actuation-/delivery part to the individual clip magazine, for which the coupling element is adapted to become interconnected with the clip advancing device when the individual clip magazine is mounted and locked/arrested in the universal handgrip by said proximal end portion on the individual clip magazine; and
an overload protection clutch in form of a sliding clutch for interrupting the force transmission in the gearing between the at least one manually graspable handle and the coupling element when the clip advancing device is limited in its conveying movement by one of said two limiting stops.

US Pat. No. 10,390,804

SAMPLE COLLECTION

NEPESMO LIMITED, London ...

1. A sample collection apparatus comprising a filter assembly to filter samples of saliva collected therein, the filter assembly comprising:a first filter element arranged to separate relatively large particulate matter from a sample, by action of gravity drawing the relatively smaller particulate matter and liquid components through the first filter element,
the first filter element comprises an upwardly angled conical or frustoconical first filter surface, arranged with a wall, to pool the sample in a corner region between the first filter surface and the wall;
wherein the filter assembly comprises a second filter element; and
wherein the first and second filter elements are arranged in the filter assembly such that the output side of the first filter element is in fluid communication with the input side of the second filter element, and wherein the second filter element is arranged to separate relatively small particulate matter from a sample, by action of gravity drawing the liquid component through the second filter element such that only particulate matter below a predetermined threshold remains with the filtered liquid component.

US Pat. No. 10,390,803

FECES SAMPLING AND DETECTING DEVICE AND METHOD FOR DETECTING FECES BASED ON THE DEVICE

W.H.P.M. BIORESEARCH AND ...

1. A feces sampling and detecting device comprising:a detector, wherein a plurality of detecting strips are provided in the detector;
a collector accommodated in the detector detachably;
a feces sampler for sealing the collector detachably; and
at least one puncturing part arranged at a bottom of the detector and facing the collector,
wherein the feces sampling and detecting device further comprises a notch provided at a top of a sidewall of the detector, the sidewall having a top and an opposite bottom, the notch extending downwardly from the top of the sidewall;
wherein the notch has a length extending downwardly from the top of the sidewall and the puncturing part has a height extending upwardly from the bottom of the detector, the length being substantially equal to the height;
wherein the notch has a width substantially perpendicular to the length, the width being adapted to allow a user to place a finger for pressing the collector or allow an automatic machine to press the collector to puncture the collector by the puncturing part; and
wherein the sum of the combined height of the feces sampler and the collector and the height of the puncturing part is less than or equal to the height of the detector, such that the top surface of the collector is below or in flush with the top surface of the detector prior to the puncturing of the collector by the puncturing part,
wherein:
the puncturing part comprises a plurality of identical right triangles attached to one another;
relatively long right-angle sides of the plurality of identical right triangles are attached to one another to form a central post, such that the plurality of identical right triangles are attached to one another through the central post, wherein the plurality of identical right triangles are disposed radially equal-distantly with respect to the central post;
a relatively short right-angle side of each of the right triangles is attached to the bottom of the detector; and
a diameter of the puncturing part decreases gradually towards the collector from the bottom of the detector.

US Pat. No. 10,390,773

X-RAY COMPUTED TOMOGRAPHY APPARATUS, A TOP-PLATE CONTROL APPARATUS, AND A TOP-PLATE CONTROL METHOD

Canon Medical Systems Cor...

1. An X ray computed tomography apparatus, comprising:a gantry including an X ray tube configured to generate X rays and an X ray detector configured to detect the X rays transmitted through a subject;
a bed arranged at a front surface side of the gantry and including a top plate configured to move toward an opening of the gantry;
input interface circuitry configured to receive input of an imaging plan concerning imaging of the subject; and
control circuitry configured to control the bed so that the top plate does not move to a back surface side of the gantry when the input interface circuitry receives the input of the imaging plan indicative of imaging a part of the subject inserted from the back surface side into the opening.

US Pat. No. 10,390,769

PERSONALIZED AVATAR RESPONSIVE TO USER PHYSICAL STATE AND CONTEXT

KC Holding I, Mayfield V...

1. A system, comprising:a memory having stored thereon computer executable components;
a processor that executes at least the following computer executable components:
an avatar rendering component configured to generate an instructor avatar and present the instructor avatar to two or more users during concurrent performance of a group fitness routine, wherein the instructor avatar is configured to facilitate performance of the group fitness routine by the two or more users;
a reception component configured to receive first biofeedback from a first user of the two or more users and second biofeedback from a second user of the two or more users during the concurrent performance of the group fitness routine;
an analysis component configured to evaluate first user performance of the group fitness routine by the first user based on comparison of the first biofeedback and the second biofeedback; and
a reaction component configured to determine an avatar reaction based on an aspect of the first user performance determined based on the comparison, and cause the instructor avatar to perform the avatar reaction.

US Pat. No. 10,390,767

HEMODYNAMIC RISK SEVERITY BASED UPON DETECTION AND QUANTIFICATION OF CARDIAC DYSRHYTHMIA BEHAVIOR USING A PULSE VOLUME WAVEFORM

Intelomed Inc., Wexford,...

1. A method for identifying a cardiac dysrhythmia condition, the method comprising:receiving, by a computing device, a biological signal emulating an arterial pulse wave from a sensor in data communication with a human body;
identifying, by the computing device, a plurality of signal peaks within the biological signal;
identifying, by the computing device, a peak amplitude for each of the plurality of signal peaks;
identifying, by the computing device, a time occurrence for each of the plurality of signal peaks;
calculating, by the computing device, a plurality of amplitude differences, wherein each amplitude difference of the plurality of amplitude differences is calculated from a first peak amplitude of a first peak and a second peak amplitude of a second peak;
calculating, by the computing device, a plurality of time differences, wherein each time difference of the plurality of time differences is calculated from a first time occurrence of the first peak and a second time occurrence of the second peak;
composing, with the computing device, a histogram reflective of at least the plurality of time differences, the histogram including at least one peak around a primary time difference of the plurality of time differences;
comparing, with the computing device, a plurality of amplitude differences with an amplitude threshold and a plurality of time differences with a time threshold to find at least one an anomalous amplitude difference that exceeds an amplitude threshold and at least one anomalous time difference that exceeds a time threshold;
determining at least one time difference dispersion metric associated with the time difference histogram, the time difference dispersion metric including at least one of a peak width of the primary time difference peak, a secondary time difference peak in addition to the primary time difference peak, or an asymmetric primary time difference peak; and
identifying a cardiac dysrhythmia condition based upon at least one of the time difference dispersion metrics associated with the time difference histogram during the occurrence of the at least one anomalous amplitude difference and the at least one anomalous time difference.

US Pat. No. 10,390,753

BLISTER STRIP

ALLTEST GmbH, Linz (AT)

1. A blister strip which can be stuck onto skin and is formed from at least two films and comprises at least one applicator for applying a medium contained in a blister and the substances contained in the medium onto or into the skin, wherein the blister strip comprises an upper film which has at least one protuberance, wherein the lower side of the upper film, which lower side surrounds each protuberance, is designed so as to be adhesive, and the blister strip comprises a lower film which covers the lower surface of the blister strip and can be pulled off from the adhesive lower side of the upper film,wherein:
in at least one protuberance of the upper film one applicator is located, said applicator is located between first and second partial volumes of the protuberance,
the first partial volume of the protuberance is located between the applicator and the lower film,
the second partial volume of the protuberance is located between the top surface of the protuberance and the applicator and contains the medium,
each applicator has at least one opening which connects the first and the second partial volumes, and
said opening is sealed in the unopened state of the blister strip to separate said first partial volume and said second partial volume of the protuberance from each other in a sealed manner.

US Pat. No. 10,390,742

NON-INVASIVE MONITOR FOR MEASURING REGIONAL SATURATION OF OXYGEN

KOHKEN MEDICAL CO., LTD.,...

1. A non-invasive monitor for measuring regional saturation of oxygen for measuring an oxygen saturation of a brain blood stream continuously in a non-invasive manner by mounting the monitor on a person's head, comprising:a sensor unit including a printed circuit board on which a light emitting unit for irradiating a surface of the forehead of the head with light of 650 to 1000 nm and a light receiving unit for receiving light which has been emitted by the light emitting unit and has propagated inside the head are mounted, wherein the sensor unit is a board-shaped member that is bent according to the shape of the forehead;
a main body unit disposed in front of the forehead when being mounted on the head, including a computation processing unit for calculating a mixed oxygen saturation of the brain blood based on a detection signal detected by the sensor unit, a display unit for displaying a computation processing result by the computation processing unit, and a power source unit for supplying power to the sensor unit, the computation processing unit, and the display unit;
a sensor holder for holding the sensor unit while the light emitting unit and the light receiving unit are disposed in an aperture portion, having a board shape abutting on the forehead and including the aperture portion penetrating in a board thickness direction thereof, wherein the sensor holder is a board-shaped member that is bent according to the shape of the forehead;
a sensor pressing board for holding the sensor unit toward the sensor holder, disposed between the sensor unit and the main body unit, wherein the sensor pressing board is a board-shaped member that is bent according to the shape of the forehead;
a connecting unit for electrically connecting the sensor unit and the main body unit; and
a headband for mounting the main body unit on the head detachably,
wherein the sensor holder, the sensor unit, the sensor pressing board, and the main body unit are integrated by being stacked in this order from the forehead-side,
wherein the light emitting unit and the light receiving unit are disposed such that a light emitting surface of the light emitting unit and a light receiving surface of the light receiving unit face the forehead-side, and a part or the whole of the forehead-side surface of the sensor unit is on the same surface as the forehead-side surface of the sensor holder or protrudes from the forehead-side surface of the sensor holder toward the forehead-side,
wherein the sensor unit includes a right light emitting unit and a left light emitting unit as the light emitting unit and includes a right light receiving unit and a left light receiving unit as the light receiving unit, and the left light receiving unit, the left light emitting unit, the right light emitting unit, and the right light receiving unit are disposed in this order in a lateral direction of the forehead,
wherein the left light emitting unit and the right light emitting unit are disposed in linear symmetry with a virtual straight line between the left light emitting unit and the right light emitting unit as a symmetric axis,
wherein the left light receiving unit and the right light emitting unit are disposed in linear symmetry with the virtual straight line as a symmetric axis,
wherein the right light emitting unit and the right light receiving unit is for measuring the oxygen saturation of the right brain, and the left light emitting unit and the left light receiving unit is for measuring the oxygen saturation of the left brain, and
wherein the main body unit has a center mark, and the position of the center mark in a lateral direction of the forehead is on the virtual straight line.

US Pat. No. 10,390,714

DEVICES FOR FIXING A SENSOR IN A LUMEN

Remon Medical Technologie...

1. A method of implanting a sensing device within an anatomical vessel network having a main anatomical vessel and an anatomical vessel branch of the main anatomical vessel, the method comprising:expanding a fixation element coupled to a sensing element of the device, at a first end of the sensing element, into firm contact with the wall of the main anatomical vessel at a longitudinal location proximal to and spaced apart from an ostium of the anatomical vessel branch; and
expanding a stabilization element coupled to the sensing element, at a second end of the sensing element, into firm contact with the wall of the main anatomical vessel at a longitudinal location distal to and spaced apart from the ostium of the anatomical vessel branch, wherein the stabilization element is a flange that consists of a single wire loop coupled, at a first end of the single wire loop, to the second end of the sensing element, extending away from the second end of the sensing element, curving back toward the second end of the sensing element, and coupled, at a second end of the single wire loop, to the second end of the sensing element; and wherein only the sensing element is positioned at the ostium of the anatomical vessel branch.

US Pat. No. 10,390,696

DYNAMIC COMPUTER IMAGES FOR IMPROVING VISUAL PERCEPTION

EYEKON E.R.D. LTD., Rama...

1. A method for presenting dynamic-images to a user, the method comprising processor implemented steps of:displaying, at a given time-step (n=k), one or more dynamic-images to the user, wherein a dynamic-image is an image initially displayed at a specific location and moving to another location, during the given time-step (n=k);
receiving, at the given time-step (n=k), the user's response to the displayed dynamic-image/s;
analyzing, one or more of the user's responses, received at the given time-step (n=k) and/or at former time-step/s (n adjusting, for at least one of the following time-steps (n>k), one or more parameters of at least one of the dynamic-images, responsively to a predetermined threshold for—or a state of—the change.

US Pat. No. 10,390,683

DISHWASHER

Electrolux Appliances Akt...

1. A dishwasher comprising:(a) a basket for accommodating articles to be cleaned;
(b) tubing located at the bottom of the basket, said tubing being adapted for connection to a supply of washing liquid;
(c) a plurality of utensil holders independently rotatably connected to the tubing, each of said plurality of utensil holders being adapted to be rotated between an operating position in which an article to be cleaned can be held at said utensil holder, and a resting position in which said utensil holder is configured to be stowed away, wherein the plurality of utensil holders are each independently rotatable relative to each other; and
(d) a plurality of nozzles configured to communicate with said tubing and located to direct a jet of washing liquid towards an article held at the utensil holder;
wherein each utensil holder comprises a clamping portion adapted to engage an article to be cleaned, wherein said nozzle is located in proximity of the clamping portion; and
wherein each utensil holder comprises a valve which provides for fluid communication between the tubing and a respective one of the plurality of nozzles when the respective utensil holder rotated into the operating position, and which blocks the fluid communication between the tubing and the respective one of the plurality of nozzles when the respective utensil holder is rotated into the resting position.

US Pat. No. 10,390,661

UTENSIL RETAINING DEVICE

F.N. Sharp, LLC

1. A utensil holder comprising:a main body having a void therein, the main body comprising an outer surface, an interior surface, an upper base, a lower base, the outer surface of the main body forming a plurality of elongated wings, each of the plurality of elongated wings having a plurality of outer faces, at least one of the plurality of outer faces adapted to receive at least one utensil thereon;
at least one magnet positioned within the void on an interior surface of at least one of the plurality of elongated wings, each of the at least one magnet imparting a magnetic field radially outward, the magnetic field of sufficient strength to be adapted to removably secure at least one utensil against the at least one of the plurality of the outer faces of at least one of the plurality of elongated wings in a use position; and
support material within the void of the main body, the support material configured to removably secure the at least one utensil within the void in a storage position when not in use.

US Pat. No. 10,390,657

GRID FOR COOKING FOOD

SMEG S.p.A., (IT)

1. A grid for cooking food, in particular for equipping a barbecue, the grid comprising:a plate comprising an upper face configured for being set in contact with food and a lower face configured for facing a heat source;
the upper face comprising a plurality of channels parallel to one another and configured for conveying liquids, each channel being separated from an adjacent channel by a substantially vertical partition;
the plate comprising a plurality of openings for enabling hot air and combustion smoke produced by the heat source to lap the food;
wherein the openings are provided in the form of slits parallel to the channels at portions of connection of two adjacent channels with the corresponding partition so that the partitions form bridges that are parallel to the channels and overlie the slits, the openings defining paths for the hot air and combustion smoke;
wherein each of the openings comprises an inlet on the lower face and two lateral outlets provided in a bottom vertical portion of the partition that provides a passageway from the inlet to two adjacent channels; and
wherein the plate is made of a single piece of cast iron.

US Pat. No. 10,390,653

BEVERAGE PREPARATION MODULE HAVING ADDITIONAL MODULES FOR SELF-SERVICE BEVERAGE VENDING MACHINES

SCHAERER A.G., Zuchwil (...

1. A self-service beverage vending machine, comprising:a beverage cabinet defining an interior of said self-service beverage vending machine,
a beverage preparation module disposed within the beverage cabinet,
a holder for mounting the beverage preparation module,
one or more additional modules disposed within the beverage cabinet,
one or more holders for mounting the one or more additional modules,
an outflow module disposed within the beverage cabinet;
wherein the beverage preparation module is a self-contained beverage preparation module comprising:
a module housing configured to be removably disposed within said interior of said self-service beverage vending machine;
a water connection attached to the module housing to provide a water supply thereto;
a preparation device disposed within the module housing for preparing a beverage using water supplied to the water connection,
a communication interface and a control unit, provided to the module housing, to which beverage preparation parameters are transmittable via the communication interface, and which is configured for controlling the preparation device within the module housing in order to prepare a beverage based on the beverage preparation parameters,
a beverage outlet provided to the module housing for discharging the beverage prepared by the preparation device into a cup intended to be removed from said self-service beverage vending machine,
at least one module interface for connecting the control unit to the one or more additional modules, and
at least one fluid interface for connecting the water connection and the preparation device to the one or more additional modules, wherein the at least one fluid interface is configured for providing a fluid connection between the preparation device and the one or more additional modules, such that water, hot water, steam, or cleaning fluid can be exchanged between the preparation device and the one or more additional modules via the at least one fluid interface,
wherein the water connection, the preparation device, the communication interface, the control unit, the beverage outlet, the at least one module interface and the at least one fluid interface are provided in and/or on the module housing to form a unitary unit;
wherein the one or more additional modules includes one of the following: a milk module, a powder module, a syrup module, and a cleaning module, and wherein the one or more additional modules comprises: an additional module interface for connection to the at least one module interface of the beverage preparation module, the additional module interface being configured for transmitting electrical power and/or electrical control signals, and a water interface and/or steam interface for connection to the at least one fluid interface of the beverage preparation module; and
wherein the outflow module includes at least one of the following features: milk duct, steam duct, milk-steam mixing chamber, powdered beverage duct, coffee duct, and
wherein the at least one module interface and the at least one fluid interface are disposed on the beverage preparation module.

US Pat. No. 10,390,652

MULTIPLE DOSING DEVICE AND MAGAZINE

EKBERG EMBALLAGE AB, S-V...

1. A multiple dosing device for releasing one or more doses of an additive, comprising:a magazine having a number of through openings each receiving a tube, wherein the tubes are open at both ends and each contains a dose of the additive, the through openings and tubes extending axially between two opposite ends of the magazine, the tubes are arranged and moveable in an axial direction inside respective through openings;
an upper foil and a lower foil placed and adhered to the opposite ends of the magazine, wherein the ends of the tubes are placed abutting or adjacent the upper and lower foils, respectively; and
an activation part, wherein each of the tubes has a pointed lower end for penetrating the lower foil, the activation part has push buttons, the push buttons are placed for controlling the axial position of one of the tubes each, and each push button has a pointed lower end for penetrating the upper foil, and
wherein each push button is arranged to move one of the tubes of the magazine from a non-activated position to an activated position releasing the dose of additive of the one of the tubes and each push button continues its movement inside the corresponding one of the tubes.

US Pat. No. 10,390,620

ERGONOMIC SEATING SYSTEM, TILT-LOCK CONTROL AND REMOTE POWERING METHOD AND APPARATUS

Steelcase Inc., Grand Ra...

1. A work environment adjustment system for supporting a user in a plurality of ergonomic positions, the system comprising:a first assembly having at least first and second components that are adjustable between at least first and second relative positions to support the user in first and second different postures, the first assembly further including a processor, an actuator and a wireless receiver;
a second assembly separate from the first assembly and including a furniture assembly, the furniture assembly including at least first and second components that are adjustable between at least first and second relative positions to support the user in the first and second different postures, the second assembly further including a processor and a wireless transmitter;
wherein, upon the relative position of the second assembly first and second components being changed from the first position to the second position, the second assembly processor transmits a wireless signal to the receiver;
wherein, upon receiving the wireless signal at the receiver, the first assembly processor controls the actuator to adjust the position of the first assembly first and second components from the first position to the second position.

US Pat. No. 10,390,604

FLEXIBLE CONTAINER

Hydrapak LLC, Oakland, C...

1. An assembly for making a flexible container device comprising:a container top;
a container bottom;
a flexible reservoir panel having a first open end and a second open end,
wherein the flexible reservoir panel is attached at the first open end to the container top,
wherein the flexible reservoir panel is attached at the second open end to the container bottom,
wherein the flexible reservoir panel is attached to itself at a seam and forms an internal volume of the flexible container device,
wherein the seam has a seam gap and the flexible reservoir panel is not attached to itself at the seam gap; and
an anvil extending into the internal volume through an opening in the flexible container device,
wherein the anvil contacts at least one of the container top and the container bottom.

US Pat. No. 10,390,601

SYSTEM AND METHOD FOR APPLYING COSMETICS

Je Matadi, Inc, Stafford...

1. A system for applying cosmetics, comprising:a lower housing, having an outlet member near a bottom edge thereof;
a compressor module contained in said lower housing, said compressor module having a compressed air outlet in fluid connection with said outlet member;
an upper housing covering said compressor module in said lower housing and being affixed to said lower housing, said upper housing being comprised of a mount on an exterior of said upper housing;
a control module being comprised of a view screen, printed circuit board connected to said compressor module, an interactive control board connected to said printed circuit board, and a speaker, said control module being contained in said upper housing, said upper housing being between said compressor module and said control module;
a cover fitted over said control module in said upper housing and affixed to said upper housing, forming an integral unit of said lower housing, said upper housing and said cover; and
a cosmetics applicator in fluid connection with said compressor module through said outlet member, wherein said cosmetics applicator is comprised of an air hose and an airbrush stylus, said air hose connected to said outlet member, wherein said compressor module supplies compressed air to said airbrush stylus, and wherein said control module regulates compressed air to said airbrush stylus.

US Pat. No. 10,390,586

VENTILATION OF FOOTWEAR

1. A method for ventilating a footwear, comprising:providing a ventilation apparatus comprising a set of parts attached to said footwear, said set of parts comprising:
an electric pump disposed on an ankle section of said footwear;
a switching unit in electrical communication with said electric pump, said switching unit disposed on said ankle section of said footwear, wherein said switching unit selectively changes modes of operation of said electric pump, said modes of operation comprising:
a pump mode for pumping an ambient fluid from an ambient environment external to said footwear into a cavity of said footwear; and
an exhaust mode for exhausting an exhaust fluid from said cavity of said footwear to said ambient environment external to said footwear;
a fluid diffuser comprising:
a diffusing member positioned within said cavity of said footwear and operably connected to said electric pump in said ankle section through a feed pipe; and
said feed pipe connected to and extending from said electric pump in said ankle section into said diffusing member, said feed pipe positioned within said footwear proximal to an inner surface of said footwear;
switching said electric pump to said pump mode using said switching unit and pumping said ambient fluid from said ambient environment external to said footwear into said cavity of said footwear via said feed pipe and said diffusing member; and
switching said electric pump to said exhaust mode using said switching unit and suctioning and transferring said exhaust fluid in said cavity of said footwear to said ambient environment external to said footwear via said feed pipe and said diffusing member.

US Pat. No. 10,390,579

HELMET WITH AUTOMATIC EMERGENCY PROCESSING

Harman Becker Automotive ...

1. A helmet comprising:a rigid shell configured to spatially divide a shell interior from a shell ambience;
an acoustic front-end comprising at least one loudspeaker disposed in the shell interior, at least one interior microphone configured to pick up sound in the shell interior when the helmet is worn by a user, and at least one exterior microphone, the at least one interior microphone having a sensitivity that is higher in the shell interior than in the shell ambience, and the at least one exterior microphone having a sensitivity that is higher in the shell ambience than in the shell interior when the helmet is worn by the user;
a controllable transceiver operatively coupled to the acoustic front-end, the controllable transceiver being configured to establish a speech link with a counterpart transceiver via at least one wireless communication channel; and
a controller configured to receive an emergency indication signal and to control the controllable transceiver to automatically establish via the at least one wireless communication channel the speech link between the acoustic front-end and the counterpart transceiver when the emergency indication signal is received.

US Pat. No. 10,390,575

MEDICAL GLOVE FOR USE WHEN TAKING A PULSE

Summit Glove Inc., Miner...

1. A glove comprising:a wrist region;
a palm region extending outwardly from the wrist region;
a digit region extending outwardly from the palm region;
a hand-receiving cavity defined by the wrist region, palm region and digit region, and an opening to said cavity being defined by the wrist region, said cavity being adapted to receive a hand of a user inserted through the opening; and
wherein the wrist region, palm region and digit region are comprised of a first layer of nitrile rubber that is free of or essentially free of elements, components or compounds that cause hypersensitivity or allergic reaction in persons who wear the glove, and wherein the nitrile rubber is free of or essentially free of zinc and/or sulfur and/or accelerators; and
wherein the wrist region, palm region, and digit region further include at least one additional layer that is located adjacent one or the other of an inner surface or an outer surface of the first layer of nitrile rubber; and wherein the additional layer is comprised of an elastomeric polymer.

US Pat. No. 10,390,557

ORAL SMOKELESS TOBACCO COMPOSITION COMPRISING LIBERATED, DELIGNIFIED TOBACCO FIBRES AND A METHOD FOR ITS MANUFACTURE

Swedish Match North Europ...

1. An oral smokeless tobacco composition comprising liberated, delignified tobacco fibres, wherein the liberated, delignified tobacco fibres are 1 to 75 weight percent of the dry weight of the oral smokeless tobacco composition, wherein the liberated, delignified tobacco fibres have an average length-to-width ratio equal to or greater than 4:1 and equal to or lower than 100:1, and wherein the liberated, delignified tobacco fibres have a number-weighted average width equal to or greater than about 34 ?m to equal to or less than about 42 ?m.

US Pat. No. 10,390,550

METHOD FOR PROCESSING BIOMATERIALS

HBC Holding Company, LLC,...

1. A system comprising:a first applicator comprising an end portion, a waveguide, a material entry port, and a material exit port;
an electromagnetic generator connected to the first applicator so as to provide electromagnetic energy to the first applicator; and
a conduit comprising an interior and configured to carry heterogeneous materials comprising liquid and solid materials,
wherein the conduit is attached to the first applicator so that the heterogeneous materials passes through the material entry port and the material exit port, and
wherein the conduit interior comprises a top portion, a bottom portion and a center portion, wherein the conduit is aligned along the longitudinal length of the first applicator so that a higher concentration of the electromagnetic energy is applied to the bottom portion relative to the center and top portions of the conduit's interior thereby causing materials in the bottom portion of the conduit's interior to heat faster than materials in the center and top portions of the conduit's interior.

US Pat. No. 10,390,539

DEVICE FOR SEPARATING INDIVIDUAL SAUSAGES SEPARATED FROM ONE ANOTHER BY TWIST POINTS

INOTEC GMBH MASCHINENENTW...

1. A device for separating individual sausages (12), which are separated from one another by twist points (15), at a cutting point (5), wherein a sensor (6) for detecting the twist point (15) is connected upstream of the cutting point (5), wherein, upstream of the cutting point (5), there is positioned at least one further sensor (7) which runs parallel to the sensor (6) and which is located closer to the cutting point (5) than the sensor (6), wherein the sensors (6, 7) each generate an infrared light shell.

US Pat. No. 10,390,537

STRUCTURE OF DOUGH PREPARATION MACHINE

ANKO FOOD MACHINE CO., LT...

1. A dough preparation machine, comprising a power unit, which drives, via a rotational speed mechanism, a helical screw shaft, the helical screw shaft being arranged to extend into a dough chamber, a jet nozzle being arranged on an end of the dough chamber such that the dough is positionable into the dough chamber and driven and compressed through rotation of the helical screw shaft to be discharged through the jet nozzle, the dough chamber being provided with a bearing that is set at a location above the helical screw shaft, the bearing receiving and coupled to an auxiliary dough driver, which is driven by the power unit and the rotational speed mechanism,wherein the auxiliary dough driver comprises, at least, a rotary axle, the rotary axle comprising a shaft hole extending therethrough in an axial direction, the rotary axle being provided with at least one side opening that extends therethrough in a radial direction, the rotary axle being provided, in an outer circumference thereof, two side slots extending in a longitudinal direction and on two sides of the side opening;
two movable blades, which each comprise a driving plate in the form of an elongated plate and a retention ring, the two movable blades being respectively insertable into the rotary axle from two opposite sides thereof such that the retention rings are received in the side opening and the two driving plates are respectively received in the two side slots, a central shaft being received in and extending through the shaft hole of the rotary axle and also extending through the retention holes of the two movable blades, the central shaft being arranged to drive the rotary axle to rotate, a fastening assembly fixing the auxiliary dough driver to the bearing of the dough chamber; and
the dough chamber comprises a sidewall at a location adjacent to the auxiliary dough driver and forms a circular arc, wherein when the auxiliary dough driver is in rotation, one of the movable blades that is moving to pass through the circular arc sidewall of the dough chamber is compressed inward thereby so as to have the driving plate thereof retracted inward and received in a corresponding one of the side slots of the rotary axle, and wherein the one of the movable blades, when retracted inward, drives another one of the movable blades outward through the retention rings so that the driving plate of said another one of the movable blades is caused to project out to drive and poke the dough until being further rotated to reach the circular arc sidewall of the dough chamber to be compressed inward thereby to thereby complete a cycle of extension-retraction based operation of dough kneading and poking.

US Pat. No. 10,390,527

WEIGHTED RODENT BAIT STATIONS AND RELATED METHODS

VM PRODUCTS INC., Bedfor...

1. A rodent bait station packaged bundle comprising:a pallet;
multiple rodent bait station assemblies positioned on the pallet, where the multiple rodent bait station assemblies are stacked such that the top of one of the multiple rodent bait station assemblies supports the bottom of another of the multiple rodent bait station assemblies, each of the multiple rodent bait station assemblies comprising:
a base comprising plastic;
a lid comprising plastic and including an inner surface and internal wall portions extending away from the inner surface, the lid being lockable in a closed position relative to the base;
an anchoring base comprising concrete that is pre-molded to correspond to at least one feature of the bait station assembly, the anchoring base including a bottom surface with multiple indentions in the bottom surface;
a tray configured to be coupled to the base such that the base and tray cooperate to enclose a majority of the anchoring base; and
multiple vertically-oriented bait-holding rods enclosed by the lid and the base when the lid and the base are locked together;
a packaging container comprising a film wrapped around a portion of the multiple rodent bait station assemblies.

US Pat. No. 10,390,524

RECIPROCATING MECHANISM OF SPINNING REEL AND SPINNING REEL COMPRISING THE SAME

Shimaon Inc., Osaka (JP)...

1. A reciprocating mechanism for a fishing reel for evenly winding a fishing line onto a spool mounted on a reel body, comprising:a worm shaft having a shaft portion with intersecting spiral grooves formed on an outer surface thereof, a first shaft supporting portion supporting the shaft portion with respect to the reel body at a first end of the shaft portion and having a spherical portion at a distal end formed in a convex spherical shape, and a second shaft supporting portion supporting the shaft portion with respect to the reel body at a second end of the shaft portion;
a first supporting member with a bottomed tubular shape, having a first bottom portion abutting the spherical portion of the first shaft supporting portion of the worm shaft, and being disposed on the reel body to support the first shaft supporting portion of the worm shaft;
a second supporting member with a bottomed tubular shape, having a second bottom portion abutting the second shaft supporting, portion of the worm shaft, and being disposed on the reel body to support the second shaft supporting portion of the worm shaft; and,
a biasing member biasing at least one of the first supporting member and the second supporting member in an axial direction.

US Pat. No. 10,390,519

ANIMAL RESTRAINT DEVICE

Tim Farrar, Salt Lake Ci...

1. An animal restraint device comprising:an elongated member that extends from a first end to a second end, includes an interior surface and an exterior surface, and includes a posterior length that includes a portion of the elongated member having the first end and a remaining length that includes a portion of the elongated member having the second end;
a first connector that is positioned at the first end;
a second connector that is attached to the elongated member and positioned at a first distance from the first end;
a collar loop formed from the posterior length through attachment of the first connector to the second connector;
a first strip of hook-and-loop fasteners that is affixed to a portion of the interior surface of the elongated member; and
a second strip of hook-and-loop fasteners that is affixed to a portion of the exterior surface of the elongated member,
a third connector that is positioned at the second end; and
a fourth connector that is attached to the elongated member and is positioned at a second distance from the second end, the fourth connector being configured to be releasably attached to the third connector,
wherein the elongated member is configurable in an on-animal storage configuration in which:
one or more concentric loops are formed from the remaining length of the elongated member,
the first strip is affixed to the second strip,
the concentric loops are wrapped around the collar loop in a single rotational direction,
portions of the interior surface of the remaining length are affixed to portions of the exterior surface of the collar loop or to the exterior surface of one concentric loop of the concentric loops, and
the second end is connected to the exterior surface of an outer-most concentric loop of the concentric loops.

US Pat. No. 10,390,516

PET TOY

Cosmic Pet LLC, Wichita,...

1. A pet toy comprising:a hollow compressible body having a mouth about an opening leading to an interior of the body;
a tab having a head and a neck extending from the head, wherein the neck extends through the opening, wherein the head is larger than the opening and wherein the neck is slidable through the opening to move the head between a silent position in which the head is spaced from the mouth to allow air flow from the interior of the body through the opening between the neck and the body without producing audible sound and a squeaking position in which the head is sufficiently close to the mouth such that airflow from the interior of the body through the opening between the neck and the body and between the mouth and the head produces an audible squeaking sound.

US Pat. No. 10,390,501

SPRINKLER CONTROL SYSTEM

Technology West, LLC, Sa...

1. An apparatus, comprising:a housing containing a Wi-Fi enabled microcontroller and a relay switch disposed in the housing and in operable communication with the microcontroller;
a pair of wires extending from the housing to receive operational power for the microcontroller from a commercially available sprinkler controller;
a first control wire extending from the housing to connect to a first electrical terminal on the sprinkler controller for purpose of modifying an output of the sprinkler controller;
a second control wire extending from the housing to connect to a second electrical terminal on the sprinkler controller for purpose of modifying an output of the sprinkler controller, the first control wire and the second control wire to place the housing in-circuit with the sprinkler controller independent from electrical communication through any sprinkler valve; and
means to communicate information from the world wide web to the microcontroller to provide information upon which the decision made by the microcontroller to water or not to water may be based; wherein:
the microcontroller is programmable to operate the relay switch and thereby interrupt any valve-operating electrical output from the sprinkler controller caused by a watering schedule of the sprinkler controller, electrical communication through the first control wire and second control wire being interruptible by the relay switch responsive to a plurality of input parameters comprising forecast rainfall, temperature, and wind speed.

US Pat. No. 10,390,500

DESALINATION MEMBRANES FOR SUBSURFACE IRRIGATION

KC HARVEY ENVIRONMENTAL, ...

1. A subsurface irrigation system using saline or tainted water for irrigating crops, comprising:a source of saline water;
a plurality of spaced membrane tubes buried within soil of an irrigation field, wherein said plurality of spaced membrane tubes are fluidly connected with said source of saline water, each of said plurality of spaced membrane tubes including:
a non-porous tubular active layer formed of:
a hydrophilic material, said hydrophilic material having a thickness of between 10 nm and 200 nm between a first inside surface and a second outside surface; and
nanoparticles disposed within said hydrophilic material, wherein said non-porous tubular active layer permits diffusion of water between said inside surface and said outside surface substantially free of salts within said saline water; and
a macro-porous tubular support layer disposed about said outside surface of said non-porous tubular active layer, wherein said macro-porous support layer is formed of a hydrophobic material having pores with a nominal pore size of less than 0.8 microns; and
a pump for circulating said saline water through said plurality of spaced membrane tubes.

US Pat. No. 10,390,489

GRAIN CART WITH AIR NOZZLE

Optimal Agricultural Equi...

1. An agricultural cart for transporting particulate material comprising:a frame mounted on ground wheels for transport across agricultural land;
a transport container including one or more hoppers for containing particulate material for transportation of the particulate material across the agricultural land to a required location;
a conveyor receiving the particulate material from said one or more hoppers of the container for discharge of the particulate material from the container;
wherein the conveyor comprises a tube having a first end and a discharge end;
said one or more hoppers having a discharge opening for connection to the tube at one or more locations from the first end to the discharge end so that the particulate material from said one or more hoppers enters the tube;
a transport device in the tube which carries the particulate material along the tube from said one or more locations to the discharge end of the tube;
an air blower mounted on the cart for generating a stream of air;
and at least one nozzle mounted at or adjacent the first end of the tube directing the stream of air into the tube so as to travel from said at least one nozzle at or adjacent the first end along the tube to the discharge end so as to clean out the tube through the discharge end.

US Pat. No. 10,390,488

TRIPLEX GREENSMOWER LIFT SYSTEM

1. A triplex greensmower lift system, comprising:a lower lift arm pivotably mounted on a first horizontal axis to a frame member of a triplex greensmower;
an upper lift arm pivotably mounted to the lower lift arm on a second horizontal axis that is perpendicular to the first horizontal axis;
a yoke mount connected to the upper lift arm on a vertical pivot axis, and having a pair of yoke arms connected to a reel cutting unit;
a lifter support pivotably mounted to the lower lift arm on a third horizontal axis that is parallel to the first horizontal axis, and also connected to the reel cutting unit; and
a lift cylinder extending between the frame member and the lifter support that is retractable to pivot up the lifter support to hold the reel cutting unit approximately level as the reel cutting unit is raised from a mowing position to a transport position.
US Pat. No. 10,392,280

FIBER BUNDLE FOR BEARING MICROORGANISMS

SHANGHAI FANQING ENVIRONM...

1. A fiber bundle for bearing microorganisms comprisingfiber filaments wound into a ring shape or having two ends of fiber filaments bound into a bundle;
wherein the cross section of the fiber filaments is in a non-circular shape selected from oval shape, cashew shape, triangular shape, pentagonal shape, square shape, prismatic shape, Y shape, plum shape, cruciform shape, or Union Jack shape; and
wherein the fiber filaments have an outer surface that is smooth; and
wherein the fiber bundle has a specific surface area of from 6,600 m2/m3 to 12,000 m2/m3 and a bearing capacity of from 108 kg/m3 to 135 kg/m3.
US Pat. No. 10,390,506

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH190690

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH190690, produced by crossing a first plant of variety CV749310 with a second plant of variety CV692417, wherein representative seeds of said varieties CV749310 and CV692417 are deposited under ATCC Accession Nos. PTA-124502 and PTA-125242, respectively.
US Pat. No. 10,395,633

SOUND INSULATING SHEET MATERIAL WITH A CELLULAR STRUCTURE INCLUDING GELATINE AND/OR A PROCESS FOR PRODUCING THE SAME

ACOUSTIC SPACE PTY LTD, ...

1. A composition for producing a sheet material with a cellular structure, the composition including the following components:(a) about 5 to about 25 weight % gelatine,
(b) about 25 to about 60 weight % filler material, wherein the density of the filler material is about 2.0 to about 5.0 g/cm3,
(c) about 15 to about 40 weight % water,
(d) a cellular structure promoting agent, wherein the cellular structure promoting agent is selected from a composition including a peroxide group or a persulfate group, and
(e) an alkaline earth metal chloride.
US Pat. No. 10,391,538

METHOD OF MANUFACTURING HOT DEEP DRAWN STEEL PARTS OF SHEET METAL

Zapadoceska Univerzita V ...

1. A hot deep drawing method of manufacturing steel parts comprising:(a) heating a sheet metal blank to bring the sheet metal blank into austenitic condition;
(b) subsequently cooling critical-deformation locations of the sheet metal blank to a temperature below an austenite temperature, wherein the critical-deformation locations comprise undercooled austenite regions of the sheet metal blank and/or regions of mixed microstructures; and
(c) subjecting the sheet metal blank to a forming process comprising a forming tool.
US Pat. No. 10,392,570

METHOD FOR THE HYDROTREATMENT OF DISTILLATE CUTS USING A CATALYST MADE FROM AN AMORPHOUS MESOPOROUS ALUMINA HAVING HIGH CONNECTIVITY

IFP Energies Nouvelles, ...

1. A process for hydrotreatment of at least one liquid hydrocarbon feedstock having a weighted average temperature of more than 380° C., said process comprising:hydrotreating said liquid hydrocarbon feedstock at a temperature of between 250° C. and 430° C., at a total pressure of between 4 MPa and 20 MPa, with a ratio of volume of hydrogen to volume of liquid hydrocarbon feedstock of between 200 and 2,000 liters per liter and at an Hourly Volume Velocity, defined by the ratio of the volume flow of liquid hydrocarbon feedstock to the volume of catalyst fed into the reactor, of between 0.5 and 5 h?1,
wherein said hydrotreating is performed in the presence of at least one catalyst containing at least one metal from Group VIB and/or at least one metal from Group VIII of the periodic table and a support containing an amorphous mesoporous alumina,
wherein said amorphous mesoporous alumina is prepared by a method comprising the following steps:
a) in a first alumina precipitation step a), precipitating alumina in an aqueous reaction medium containing at least one basic precursor selected from sodium aluminate, potassium aluminate, ammonia, sodium hydroxide and potassium hydroxide and at least one acid precursor selected from aluminum sulphate, aluminum chloride, aluminum nitrate, sulphuric acid, hydrochloric acid, and nitric acid, wherein at least one of the basic or acid precursors comprises aluminum, the relative flows of the acid and basic precursors is selected to obtain a pH of the reaction medium of between 8.5 and 10.5 and the flow of the acid and basic precursor(s) containing aluminum is adjusted to obtain a rate of progress of the first alumina precipitation step a) of between 45 and 90%, the rate of progress being defined as being the alumina formed as equivalent Al2O3 in said first alumina precipitation step a) as a proportion of the total quantity of alumina formed in the method, said first alumina precipitation step a) operating at a temperature of between 20 and 40° C., and for a period of between 2 minutes and 30 minutes, wherein said first alumina precipitation step a) produces a suspension,
aa) a first heating step wherein the suspension from step a) is heated at a temperature of between 20 and 90° C. for a period of between 7 and 45 minutes,
a?) in a second alumina precipitation step a?), precipitating alumina in an aqueous reaction medium containing at least one basic precursor selected from sodium aluminate, potassium aluminate, ammonia, sodium hydroxide and potassium hydroxide and at least one acid precursor selected from aluminum sulphate, aluminum chloride, aluminum nitrate, sulphuric acid, hydrochloric acid, and nitric acid, wherein at least one of the basic or acid precursors comprises aluminum, the relative flow of the acid and basic precursors is selected to obtain a pH of the reaction medium of between 8.5 and 10.5 and the flow of the acid and basic precursor(s) containing aluminum is adjusted to obtain a rate of progress of the second alumina precipitation step a?) of between 10 and 55%, the rate of progress being defined as being the alumina formed as equivalent Al2O3 in said second alumina precipitation step a?) as a proportion of the total quantity of alumina formed in the method, said step a?) operating at a temperature of between 40 and 90° C., and for a period of between 2 minutes and 30 minutes, wherein the step a?) produces a suspension,
a?a?) a second heating step wherein the suspension from step a?) is heated at a temperature of between 50 and 95° C.,
b) in a thermal treatment step, heating the suspension obtained in step a?a?) at a temperature of between 50 and 200° C. for a period of between 30 minutes and 5 hours,
c) in a filtration step, filtering the suspension obtained from thermal treatment step b) wherein an alumina gel is obtained, followed by at least one washing of the gel obtained,
d) in a drying step, drying the alumina gel obtained in step c) to obtain a powder,
e) in a shaping step, shaping the powder obtained in step d) to obtain a raw material, and
f) in a further thermal treatment step, heating the raw material obtained in step e) at a temperature of between 500 and 1000° C., in the presence or not of an air flow containing up to 60 vol. % of water.
US Pat. No. 10,396,416

PASSIVE INSULATION MATERIALS

Thermal Ceramics, Inc., ...

1. An energy storage device housing for an energy storage device, comprising(a) a plurality of electrical cells;
(b) a material for limiting thermal runaway in the device, the cells having an upper normal operating temperature and a higher threshold temperature above which the cells are liable to thermal runaway, the material comprising a ceramic matrix that incorporates an inorganic gas-generating endothermic material, and in which:
the ceramic matrix is capable of providing thermal insulation properties at and above the upper normal operating temperature;
the gas-generating endothermic material is selected to undergo one or more endothermic reactions between the upper normal operating temperature and the higher threshold temperature;
one or more of said reactions results in the evolution of gases;
the ceramic matrix has sufficient porosity to permit said gases to vent from the material and thereby remove heat from the material; and
(c) a venting system forcibly openable by the generation of the gases, wherein the venting system forms part of the housing, with evolution of gases from an incident cell being releasable through the vent so as to prevent neighboring cells from reaching a critical ignition temperature,
wherein the material for limiting thermal runaway in the device comprises a formulation of:
Ceramic Oxide: 0-60 wt %
Opacifier: 0-30 wt %
Endothermic material: 10-90 wt %
Dry Binder: 0-10 wt %
Liquid Binder: 0-60 wt %
Fibre: 0-60 wt %
with the above formulation amounting to greater than 60%, greater than 70%, greater than 80%, or greater than 90% of the composition.
US Pat. No. 10,390,533

SURFACES WITH OLIGOMERIC OR POLYMERIC ANTIMICROBIALS

ORTHOBOND CORPORATION, N...

1. An article comprising:a surface having an antimicrobial layer disposed thereon, the antimicrobial layer comprising:
an organophosphorus layer and antimicrobial oligomers or polymers bonded to the organophosphorus layer,
wherein the surface comprises a metal selected from a group consisting of titanium, a titanium alloy, stainless steel, a cobalt chrome alloy, nickel, molybdenum, tantalum, zirconium, magnesium, and an alloy containing at least one of nickel, molybdenum, tantalum, zirconium and magnesium,
wherein the antimicrobial oligomers or polymers comprise about 3 to about 50,000 repeating antimicrobial monomer units, and
wherein the antimicrobial monomer units comprise ammonium salts or pyridinium salts.
US Pat. No. 10,391,045

COMPOSITION CONTAINING P-MENTHANE-3, 8-DIOL AND ITS USE AS INSECT REPELLANT

1. A moderately viscous liquid suitable for being used as an insect repellent, said liquid comprising from 5 to 12% w/w of PMD-citronellal acetal, from 7 to 14% w/w isopulegol and the remainder being p-menthane-3,8-diol, which approximates to a ternary eutectic and is liquid at ambient temperatures.
US Pat. No. 10,391,048

RECOMBINANT HIGH-STABILITY SUPEROXIDE DISMUTASE AND APPLICATION THEREOF

Hangzhou Redox Pharmatech...

1. A superoxide dismutase comprising the amino acid sequence of SEQ ID NO:4.
US Pat. No. 10,392,589

METHOD FOR EXTRACTION AND DISSOLUTION OF HOP ACIDS IN AQUEOUS MEDIA

IFAST NV, Roosdaal (BE)

1. A method for preparing a brewed beverage, comprising:adding at least one type of complexes of hop acids, with at least one type of carbon-containing chemical substance(s), with at least one functional group containing a nitrogen atom with a lone electron pair and at least one other polar and/or hydrophilic functional group; wherein said adding is during the brewing process, wherein said adding is to a wort; and wherein said hop acids are selected from the group consisting of alpha-acids, oxidized alpha-acids, beta-acids, and oxidized beta-acids.
US Pat. No. 10,391,051

ORAL CARE COMPOSITION COMPRISING CUTTLEFISH BONE POWDER AND USES THEREOF

VISIONATUROLAB INC., Bla...

1. A method for preparing a demineralized cuttlefish bone powder, the method comprising:(a) grinding a cuttlefish bone to obtain a coarse cuttlefish bone powder;
(b) sieving the coarse bone powder to obtain a first cuttlefish bone powder having particle size from 60 microns to 61 microns;
(c) mildly demineralizing the first cuttlefish bone powder in a solution of ammonium chloride or ammonium acetate having a pH of about 4.5 to about 5.5, at a temperature and for a period of time sufficient to obtain a demineralized cuttlefish bone powder having more than 95% (w/w) calcium carbonate content;
(d) washing the demineralized cuttlefish bone powder until a neutral pH is reached; and
(e) drying the demineralized cuttlefish bone powder.
US Pat. No. 10,390,544

MUNG BEAN PROTEIN GEL COMPOSITION AND CHEESE-LIKE FOOD

FUJI OIL COMPANY LIMITED,...

1. A gelled composition of mung bean protein comprising a mung bean protein and an alkali metal ion,wherein the gelled composition of mung bean protein comprises the alkali metal ion being at least 50 mM and no greater than 3M based on the total amount of the gelled composition of mung bean protein,
wherein the alkali metal ion is at least one of sodium ion and potassium ion, and
wherein the gelled composition of mung bean protein does not comprise soybean protein.
US Pat. No. 10,391,059

ORAL RAPAMYCIN NANOPARTICLE PREPARATIONS AND USE

Rapamycin Holdings, Inc.,...

1. A method of orally administering a rapamycin to an animal subject, including a human animal subject, comprising:a. preparing or otherwise obtaining a microparticle pharmaceutical preparation, comprising:
i. a solid excipient matrix comprising a polymer composition that remains intact when exposed to acidic conditions of the alimentary canal of an animal of the type of said subject animal and that disintegrates when exposed to basic conditions of targeted portions of said alimentary canal, said polymer composition comprising a copolymer of methacrylic acid; and
ii. nanoparticles dispersed within said solid excipient matrix, said nanoparticles comprising a micelle-inducing compound comprising sodium cholate and a pharmaceutically active core;
iii. said pharmaceutically active core comprising a rapamycin;
iv. said micelle-inducing compound naturally inducing formation of micelles within a solution of said micelle-inducing compound, said micelles having properties that promote stability of said rapamycin when said nanoparticles are dispersed within said matrix; and
b. orally administering said preparation to said animal subject multiple times per week over a multi-week duration, in efficacious amounts, wherein said animal subject is in need of or treatment, or delayed progression, of one or more oncologic, neurologic or autoimmune maladies.
US Pat. No. 10,392,601

IN VITRO MATURATION OF A MAMMALIAN CUMULUS OOCYTE COMPLEX

Vrije Universiteit Brusse...

1. A capacitation medium for in vitro maturation of an immature mammalian cumulus oocyte complex, the medium comprising 0.1-50 nM C-type natriuretic peptide (CNP), estradiol and Follicle Stimulating Hormone (FSH).
US Pat. No. 10,392,604

ATTENUATED INFLUENZA VECTORS FOR THE PREVENTION AND/OR TREATMENT OF INFECTIOUS DISEASES AND FOR THE TREATMENT OF ONCOLOGICAL DISEASES

PHARMENTERPRISES BIOTECH ...

1. An attenuated influenza A virus inducing a cross-protective response against influenza A and B viruses, comprising a chimeric NS fragment including a truncated reading frame of an NS1 protein and a Nep gene heterologous sequence, wherein said truncated reading frame of the NS1 protein is derived from H1N1 influenza virus subtype, and the Nep gene heterologous sequence is derived from H2N2 influenza virus subtype and wherein said truncated reading frame encodes the NS1 protein consisting of 124 amino acid residues corresponding to SEQ ID NO: 4.
US Pat. No. 10,392,605

P97-IDS FUSION PROTEINS

Bioasis Technologies Inc....

1. A p97 (melanotransferrin) fusion protein, comprising an iduronate-2-sulfatase (IDS) polypeptide fused to the N-terminus of a p97 polypeptide fragment and an optional heterologous peptide linker (L) in between, wherein the p97 polypeptide fragment consists of the amino acid sequence having at least 80% sequence identity to DSSHAFTLDELR (SEQ ID NO: 14) and having transport activity.
US Pat. No. 10,393,374

PROCESS FOR THE INCINERATION OF ACTIVATED COAL-SUPPORTED PGM CATALYSTS

HERAEUS PRECIOUS METALS N...

1. A process for the incineration of activated coal-supported PGM catalysts, the process comprising a joint incineration of a multilayer arrangement,wherein the multilayer arrangement comprises (i) a top layer of particulate activated coal-supported PGM catalyst, (ii) a layer of coarse charcoal located beneath said top layer and, optionally, (iii) a layer of particulate coke located beneath the charcoal layer, and
wherein an upward flow of oxidizing gas is homogeneously passed through said multilayer arrangement during the incineration.
US Pat. No. 10,393,633

SAMPLE FIXATION AND STABILISATION

RNASSIST LTD., Cambridge...

1. A method of inhibiting the degradation of a sample, comprising (a) mixing said sample with or immersing said sample in a eutectic solvent comprising a first component and a second component, wherein said first component is trimethylglycine and said second component is trifluoroacetamide; wherein said first component and said second component are in a molar ratio of between about 1:1.5 and about 1:2.5; and wherein said first component and said second component together comprise at least about 50% by weight of the combined eutectic solvent and sample; (b) incubating said sample and eutectic solvent of (a) for at least 5 minutes; and (c) processing said sample, wherein said processing comprises: microscopic examination of said sample; staining said sample; performing flow cytometry on said sample; embedding said sample; sectioning said sample; performing in situ hybridisation on said sample; performing an immunohistochemical method on said sample; detecting a protein in said sample; detecting a phosphoprotein in said sample; detecting DNA or RNA in said sample; or performing an immunocytochemical method on said sample.
US Pat. No. 10,391,074

TOPICAL PREPARATION FOR PAIN RELIEF

Sambria Pharmaceuticals, ...

1. A method of reducing a sensation of pain in a subject, comprising:applying topically directly to skin of the subject over an area of pain a therapeutic amount of a composition comprising
(a) lidocaine in an amount of about 1% to about 20%; and
(b) a penetration enhancer comprising a penetration-enhancing amount of a methylsulfonylmethane (MSM) component, and an ethoxydiglycol component, wherein the amount of the MSM component is about 1% to about 10%, and the amount of the ethoxydiglycol component is about 0.10% to about 5%,wherein the composition is effective(i) to deeply penetrate the skin of the subject,
(ii) to remain in the skin and block nerve signals affecting sensation of pain, and
(iii) to provide pain relief.
US Pat. No. 10,391,079

METHODS OF DIAGNOSING AND TREATING ALZHEIMER'S DISEASE WITH S-EQUOL

AUSIO PHARMACEUTICALS, LL...

1. A method for improving a cognitive measurement in a patient at risk of or diagnosed with Alzheimer's disease comprising administering a pharmaceutically effective amount of a formulation comprising S-equol to said patient, wherein there is an absence of genistein, daidzein, and/or IBS003569 in said formulation, and wherein said administration results in an increased ratio of platelet mitochondria cytochrome oxidase (COX) to citrate synthase (CS) in a blood sample obtained from said patient.
US Pat. No. 10,394,154

ELECTROPHOTOGRAPHIC COMPOSITION

HP Indigo B.V., Amstelve...

1. An electrophotographic composition comprising toner particles dispersed in a liquid carrier, wherein the toner particles comprise a polymer resin and porous silica particles infused with a fragrance.
US Pat. No. 10,391,080

KETOROLAC FOR THE TREATMENT OF CANCER

Cipla Limited, Mumbai (I...

1. A method for the treatment of renal cell carcinoma in a patient, the method comprising administering to said patient ketorolac, or a pharmaceutically acceptable salt or ester thereof, in an amount effective to treat renal cell carcinoma.
US Pat. No. 10,392,363

METHODS FOR TREATING PROTOZOAN INFECTIONS

Neoculi Pty Ltd., Victor...


US Pat. No. 10,392,624

GENE ENGINEERING YEAST HAVING SACCHARIFICATION FUNCTION, METHOD OF PREPARING SAME, AND APPLICATION OF SAME

ANGEL YEAST CO., LTD, Yi...

1. A yeast host cell, comprising an exogenous nucleic acid having a nucleotide sequence encoding a glucoamylase,wherein the nucleotide sequence is selected from the group consisting of:
(a) a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 16; and
(b) a nucleotide sequence comprising SEQ ID NO:15 and encodes the glucoamylase, and
wherein the yeast host cell is the Saccharomyces cerevisiae strain deposited with the China Center for Type Culture Collection as Deposit Accession No. CCTCC M 2014657.
US Pat. No. 10,391,090

METHODS FOR SOLID TUMOR TREATMENT

Crititech, Inc., Lawrenc...

1. A method for treating a solid tumor, comprising administering to a subject with a solid prostate tumor an amount effective of a composition comprising chemotherapeutic particles to treat the prostate tumor, wherein the composition is directly injected into the prostate tumor, wherein the chemotherapeutic particles comprise at least 95% paclitaxel or a pharmaceutically acceptable salt thereof, and wherein the chemotherapeutic particles have a specific surface area (SSA) of at least 10 m2/g, wherein the chemotherapeutic particles include both agglomerated chemotherapeutic particles and non-agglomerated chemotherapeutic particles.
US Pat. No. 10,391,347

PROCESS FOR BIOCHEMICAL DENATURATION OF AN ASBESTOS-CONTAINING MATERIAL

LEBSC S.R.L, Bologna (IT...

1. A process for treating an asbestos-containing material, which comprises:subjecting a food industry waste material to mixed bacterial and fungal growth and/or fermentation to produce an acidic solution/suspension; and
treating an asbestos-containing material with the acidic solution/suspension at a temperature of 120-170° C. and pressure of 2-10 bar in order to produce an asbestos-containing material that is at least partially inert;
wherein said mixed bacterial and fungal growth and/or fermentation is carried out by using bacteria of the species Acetobacter aceti and yeast of the species Saccharomyces cerevisiae.
US Pat. No. 10,392,631

FUSARIUM CHITIN SYNTHASE GENE CHS3B AND THE USE THEREOF

Huazhong Agricultural Uni...

1. An RNAi construct comprising a fragment of Fusarium chitin synthase gene Chs3b selected from the group consisting of: Chs3b-1 having the nucleotide sequence of SEQ ID NO: 2, Chs3b-2 having the nucleotide sequence of SEQ ID NO: 3, Chs3b-3 having the nucleotide sequence of SEQ ID NO: 4, Chs3b-4 having the nucleotide sequence of SEQ ID NO: 5, and Chs3b-5 having the nucleotide sequence of SEQ ID NO:6.
US Pat. No. 10,391,096

METHOD FOR TREATING THROMBOTIC DISORDERS USING QUERCETIN-CONTAINING COMPOSITIONS

Quercegen Pharmaceuticals...

1. A method for treating a thrombotic disorder, the method comprising administering to a subject in need thereof an effective amount of a composition that includes isoquercetin, vitamin B3, vitamin C, and folic acid, wherein the thrombotic disorder is venous thrombosis.
US Pat. No. 10,391,101

DERIVATIVES OF 7-FLUORO-8-CHLORO-5H-DIBENZO [B,E,] [1,4] DIAZEPINE AND USE THEREOF

VALENTEK LLC, Moscow (RU...

1. A method of treating a treatment-resistant form of schizophrenia, comprising:administering a therapeutically effective amount of a pharmaceutical composition to a subject in need thereof, wherein the pharmaceutical composition comprises an active ingredient selected from the group consisting of: (a) 11-(piperazine-1-yl)-7-fluoro-8-chloro-5H-dibenzo[b,e][1,4]diazepine; (b) 11-(4-methyl piperazine-1-yl)-7-fluoro-8-chloro-5H-dibenzo[b,e][1,4]diazepine; and (c) a pharmaceutically acceptable salt, hydrate, or solvate of (a) or (b); and
reducing one or more symptoms associated with schizophrenia, wherein said symptoms comprise symptoms of a cognitive disorder;
wherein the therapeutically effective amount comprises a daily dosage of 50 to 300 mg of the active ingredient.
US Pat. No. 10,392,640

METHOD FOR MODIFYING STARCH TO SLOW DOWN THE DIGESTION RATE

Jiangnan University, Wux...

1. A method to modify starch to slow down the digestion rate of the starch, comprising the sequential steps of:a) heating a starch slurry sample at 50 to 60° C. for 10 to 15 minutes and then adding 20 to 50 U/g starch branching enzyme (GBE) to the starch slurry sample, wherein the GBE is encoded by a GBE gene having the DNA sequence of SEQ ID NO:1;
b) incubating the starch slurry sample with the GBE at 50 to 60° C. for 4 to 20 hours;
c) heating the starch slurry sample in boiling water to obtain a gelatinized starch and inactivate the GBE;
d) incubating the gelatinized starch at 50 to 60° C. for 10 to 15 minutes and then adding 20 to 50 U/g of the GBE to the gelatinized starch;
e) incubating the gelatinized starch with the GBE at 50 to 60° C. for 4 to 20 hours;
f) heating the gelatinized starch in boiling water to terminate the enzymatic reaction; and
g) obtaining final product of modified starch after freeze-drying.
US Pat. No. 10,391,105

METHODS OF TREATING CERTAIN DEPRESSIVE DISORDERS AND DELIRIUM TREMENS

MARINUS PHARMACEUTICALS I...

1. A method of treating postpartum depression, premenstrual dysphoric disorder, menopausal depression, or delirium tremens comprising administering an effective amount of an neurosteroid formulation to a patient in need thereof; wherein the neurosteroid formulation is an ganaxolone formulation comprisinga) water;
b) sulfobutyl ether-?-cyclodextrin (CAPTISOL) and ganaxalone, wherein the ratio of sulfobutyl ether-?-cyclodextrin to ganaxolone wherein weight to weight (w/w) ratio of sulfobutyl ether-?-cyclodextrin is about 52:1 or greater; and
c) a buffer, the formulation having a pH of 6.8 to 7.6.
US Pat. No. 10,391,108

PHARMACEUTICAL TETRACYCLINE COMPOSITION FOR DERMATOLOGICAL USE

BioPharmX, Inc., San Jos...

1. A topical composition, comprising:minocycline,
a divalent cation,
a sulfite compound, and
a solvent;whereinthe minocycline is dissolved in the composition; and
the relative concentration of 4-epi-minocycline in the composition is less than 5.0% after storage at 40° C. in a sealed glass vial for 4 weeks.