US Pat. No. 10,245,417

PACKAGE FOR EXTENDED SHELF LIFE OF LIQUID CORE CATHETERS

RA MEDICAL SYSTEMS, INC.,...

1. A package assembly to extend a shelf life of a liquid core catheter, comprising:a liquid core catheter comprising a core liquid;
a polymer spiral tube which includes an inner lumen filled with a storage liquid that is soluble in or miscible with the core liquid of the liquid core catheter and which is sealed at both ends to contain the storage liquid in the inner lumen of the polymer spiral tube; and
a sealed pouch which is made of either metallized plastic or polychlorotrifluoroethylene that acts as a hermetic seal for liquids disposed within the sealed pouch and which includes a hermetically sealed inner volume with the polymer spiral tube and liquid core catheter being disposed within the hermetically sealed inner volume.

US Pat. No. 10,245,409

PACKAGING AND ORGANIZING COILS OF MEDICAL TUBING

Fresenius Medical Care Ho...

1. A device for holding medical tubing, comprising:a semi-rigid sheet having a circular shape with an edge region and an interior region disposed radially inward from the edge region on the semi-rigid sheet;
a plurality of adjustable tabs disposed on the semi-rigid sheet; and
a plurality of locking slits that receive the plurality of adjustable tabs in a configuration to secure coils of medical tubing to the semi-rigid sheet, wherein the plurality of adjustable tabs and the plurality of locking slits are disposed on the semi-rigid sheet in:
(i) a front and reverse configuration in which at least one of the plurality of adjustable tabs and at least one of the plurality of locking slits are disposed on a front side of the semi-rigid sheet, and at least another one of the plurality of adjustable tabs and at least another one of the plurality of locking slits are disposed on a reverse side of the semi-rigid sheet, and
(ii) an inverted configuration in which at least one of the plurality of locking slits is disposed in the edge region of the semi-rigid sheet and at least one of the plurality of adjustable tabs is flexible towards the edge region, and at least another one of the plurality of locking slits is disposed in the interior region of the semi-rigid sheet and at least another one of the plurality of adjustable tabs is flexible towards the interior region,
wherein each side of the semi-rigid sheet is configured to hold at least two coils of tubing, including a first coil of tubing at the edge region and a second coil of tubing at the interior region radially within the first coil of tubing, using the plurality of adjustable tabs and locking slits in the front and reverse configuration and the plurality of adjustable tabs and the plurality of locking slits in the inverted configuration.

US Pat. No. 10,245,406

VENTILATOR WITH INTEGRATED OXYGEN PRODUCTION

Ventec Life Systems, Inc....

1. A method of providing a breath to a human patient using a ventilator device, a patient circuit having a first end coupled to the ventilator device and a second end spaced apart from the ventilator device, and a patent connection configured to be coupled to the human patient, the breath having an inspiratory phase with a beginning and an end, the method comprising:detecting the beginning of the inspiratory phase of the breath has been initiated by the patient, and in response intiating delivery of a bolus of oxygen to the patient circuit, the patient circuit delivering the bolus of oxygen to the patient connection;
terminating the delivery of the bolus of oxygen before the end of the inspiratory phase of the breath; and
delivering breathing gases comprising air to the patient circuit before the end of the inspiratory phase of the breath, the patient circuit delivering the breathing gases to the patient connection; wherein
delivering the breathing gases to the patient circuit comprises providing the breathing gases to the patient circuit at a first input location of the patient circuit, and
delivering the bolus of oxygen to the patient circuit comprises providing the bolus of oxygen to the patient circuit at a second input location of the patient circuit closer than the first input location to the patient connection.

US Pat. No. 10,245,388

INJECTION DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF

Global Bio Therapeutics, ...

1. An injection device, comprising:a) a syringe barrel, wherein the syringe barrel provides a fluid reservoir;
b) a plunger configured to be controlled by the operator of the device and to move within the syringe barrel for loading and releasing fluid from the fluid reservoir in the syringe barrel;
c) an injection needle that is fixed and operably coupled to the syringe barrel providing a fluid pathway for fluid contained in the syringe barrel to be injected into a target tissue when the plunger is depressed, wherein extraction or retraction of the needle is independent of movement of the plunger;
d) an elongate sheath, comprising an internal lumen that contains the injection needle and having a distal tip that contains an opening for the injection needle, wherein:
the sheath is movable around the injection needle; and
control of the sheath is independent from movement of the plunger; and
e) a controller for positioning the sheath, comprising:
a housing, comprising at least a first and second stop to control exposure of the injection needle and that are provided within the housing at a predetermined distance from each other, wherein the stops can be locked;
a central lumen in the housing comprising a connection member, wherein the connection member is configured to be movable in the central lumen in the housing and is coupled to the sheath, wherein the proximal end of the sheath is coupled to the distal end of the connection member so that movement of the connection member controls movement of the sheath; and
a positioner mounted within the housing configured to move forward towards the distal end of the controller and rearward towards the proximal end of the controller, between the stops in the housing, wherein the positioner comprises a lock and release element that is configured in the positioner to engage the positioner with the stops, and is operatively connected to the connection member to guide movement of the connection member in the same direction, whereby movement of the positioner forward towards the distal end engages the first stop and moves the sheath to enclose the injection needle inside the lumen of the sheath, and movement of the positioner rearward towards the proximal end engages the second stop and moves the sheath to expose no more than a predetermined length of the distal tip of the injection needle through the opening for the injection needle for injection into the tissue.

US Pat. No. 10,245,387

MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. A multi-dose medicament delivery device comprising:a device front end;
a device back end;
a central longitudinal axis;
a housing having a housing front end and a housing back end;
a medicament container assembly, the medicament container assembly being configured for accommodating a medicament container with a stopper;
a dose drum that is supported in the housing via a first threaded connection;
wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered; and
wherein the dose drum is axially movable with respect to the housing in a forward direction from the dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set;
a plunger rod that is operationally associated with the stopper and supported in the housing via a second threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction, where the plunger rod has an inner surface with an inwardly radial protruding tooth corresponding to a predetermined dosing position; and
an activation assembly comprising:
a plunger rod rotator that is coupled to the dose drum and has at least one first deflecting member comprising an outwardly radial protruding tooth;
an activator rod that is axially movable with respect to the plunger rod rotator from an uncoupling position to a coupling position, wherein, when the activator rod is in the coupling position and the dose drum is rotated in the second direction from the dosing position the plunger rod does not rotate until the outwardly radial protruding tooth of the at least one first deflecting member engages the inwardly radial protrusion; and
at least one second deflecting member that is configured to lock the activator rod with respect to the plunger rod rotator in the coupling position until the dose drum reaches the initial position again.

US Pat. No. 10,245,386

FORCE AMPLIFIER

Niswey, L.L.C., Atlantic...

1. A linear force amplifier, comprising:a housing having a length;
a force multiplier having an input screw substantially non-rotating relative to said housing and having an axis, to which an input force to be amplified is applied relative to said housing, an output screw substantially non-rotating relative to said input screw, providing a resulting output force relative to said housing, and a rotating nut rotatable about said input screw axis and disposed to receive and engage each of said input screw and said output screw and disposed to engage said housing and provide a force to said housing opposite to said resulting output force, wherein said output screw is movable in a first direction when said input force is applied and is retractable opposite said first direction upon relief of said input force;
an advancement ratchet disposed to engage said output screw and receive said output force relative to said housing having an output member providing an increasing ratchet output member displacement in said first direction in response to a plurality of cycles of force multiplier output screw motion in said first direction advancement and retraction therefrom.

US Pat. No. 10,245,381

TWO-STEP AUTO-INJECTION DEVICE

Chalbourne Brasington, G...

1. An auto-injection device defining a longitudinal direction, the auto-injection device comprising:an ampoule, the ampoule comprising a fluid medicament contained between a first stopper located towards a proximal end of the ampoule and a second stopper located towards a distal end of the ampoule, wherein the first stopper includes a first recess located at a proximal edge of the first stopper and a second recess located at a distal edge of the first stopper, wherein the second recess is disposed between the first recess and the second stopper;
a first sleeve movable along the longitudinal direction relative to the ampoule;
a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule, wherein the second sleeve is movable from a proximal end of the auto-injection device towards a distal end of the auto-injection device; and
a needle located at the proximal end of the auto-injection device;
wherein the first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position, wherein in the first position the needle is unexposed along the longitudinal direction and in the second position the needle is exposed along the longitudinal direction, further wherein a proximal end of the first sleeve is in direct contact with a proximal end of the second sleeve in the second position, and
wherein the second sleeve is movable along the longitudinal direction relative to the ampoule between a first position and a second position, wherein in the first position the needle is fluidly isolated from the fluid medicament and in the second position the needle is in fluid communication with the fluid medicament.

US Pat. No. 10,245,379

CANNULATED DOSE DELIVERY DEVICE, SYSTEM AND METHOD OF USE

Med Dose Solutions, LLC, ...

1. An apparatus comprising:a plunger housed in a barrel, wherein the plunger comprises;
a plunger proximal end connector configured to receive a washing agent;
a plunger end cap configured to facilitate the washing of a delivery chamber of the barrel;
an elongated cylinder having an internal chamber defining a fluid pathway between the plunger proximal end connector and the plunger end cap; wherein the plunger end cap comprises a plurality of slits in the distal end of the plunger end cap, wherein the slits are spaced apart.

US Pat. No. 10,245,375

SELF-ORIENTING SYRINGE AND SYRINGE INTERFACE

BAYER HEALTHCARE LLC, Wh...

1. A medical injector comprising at least one syringe port for engaging a syringe, the at least one syringe port comprising a locking mechanism comprising: a housing; a first retaining ring at a distal end of the housing, the first retaining ring having a central opening and a sidewall, wherein the sidewall has one or more first recesses extending radially outward into the sidewall and lateral surfaces of each first recess defining a travel path for guiding movement of one or more retaining lugs of the syringe; anda second retaining ring that is rotatable relative to the first retaining ring and the housing,
wherein the second retaining ring comprising one or more locking elements extending radially inward from an inner sidewall of the second retaining ring and are separated by one or more second recesses for receiving the one or more retaining lugs when an insertion section of the syringe is inserted through the central opening of the first retaining ring, wherein the one or more locking elements comprise a first inclined surface for engaging a corresponding inclined surface of the one or more retaining lugs for axially ejecting the syringe upon disengagement of the syringe from the at least one syringe port.

US Pat. No. 10,245,367

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

HeartWare, Inc., Miami L...

1. A portable lung assist system, comprising:an implantable blood pump having a pump outlet and a pump inlet configured for communication with a circulatory system of a patient at an inlet location; and
an external and portable blood oxygenator having a blood inlet releasably connectable to the pump outlet and a blood outlet releasably connectable to the circulatory system of the patient at a return location; and
a bypass conduit connectable to the blood pump, wherein the oxygenator and the bypass conduit are in continuous fluid communication with the blood pump when the blood inlet is connected to the pump outlet.

US Pat. No. 10,245,363

CATHETER-BASED PUMP FOR IMPROVING ORGAN FUNCTION

Stanton J. Rowe, Newport...

1. A method for improving renal function of a patient, comprising:mechanically occluding an inferior vena cava downstream of a renal vein ostium to form an upstream region and a downstream region of the inferior vena cava; and
mechanically pumping blood through the inferior vena cava from the upstream region to a discharge location in the downstream region while the inferior vena cava is occluded, wherein the blood remains in the inferior vena cava while being mechanically pumped.

US Pat. No. 10,245,362

BLOOD PUMP FOR TREATMENT OF BRADYCARDIA

HeartWare, Inc., Miami L...

1. A ventricular assist device comprising:a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery;
a pump drive circuit for applying power to the pump;
a pump drive circuit to control the speed of the pump;
one or more sensors for sensing one or more electrogram signals in a patient;
a signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being configured to receive the electrogram signals and:
determine an impending onset or absence of a bradycardia arrhythmia based on the electrogram signals from the sensors;
during the impeding onset of a bradycardia arrhythmia, determine the impending onset of sinus bradycardia or heart block;
control power supplied to the pump from the pump drive circuit so as to control the speed of the pump and:
operate the pump in a normal sinus rhythm mode in the absence of an arrhythmia;
operate the pump in a first modified mode of operation during the impending onset of heart block or sinus bradycardia.

US Pat. No. 10,245,357

SYSTEM AND KIT FOR THE COLLECTION AND PROCESSING OF AMNIOTIC FLUID AND PLACENTAL ASPIRATE

PENSARA, INC, Richmond, ...

6. A kit for collection, separation and reuse of cellular material from amniotic fluid and placental aspirate comprising:a canister having a coil, wherein the coil is hollow and has a tear drop shaped cross-section, and a cellular accumulation chamber, said cellular accumulation chamber having a port, said canister having an inlet and an outlet, said coil connected to said inlet and to said outlet, said canister suitable for attachment to a vacuum line;
a syringe having a needle suitable for insertion into said port of said cellular accumulation chamber; and
a dual-chambered applicator suitable for receiving cellular material from said syringe.

US Pat. No. 10,245,338

ULTRAVIOLET DIFFUSIVE ILLUMINATION

Sensor Electronic Technol...

1. A system comprising:an illuminator including:
a reflective cavity comprising a plurality of surfaces, wherein at least one of the plurality of surfaces is formed of a first material configured to reflect at least 70% of ultraviolet radiation, wherein the first material is patterned to include a plurality of diffusive elements, and wherein at least one of the plurality of surfaces is formed of a second material configured to transmit at least 30% of the ultraviolet radiation through the second material and out of the reflective cavity and reflect at least 10% of the ultraviolet radiation;
a plurality of ultraviolet radiation sources located within the reflective cavity; and
a set of optical elements located within the reflective cavity and configured to distribute the ultraviolet radiation within the cavity before the ultraviolet radiation exits the reflective cavity through the second material, wherein each optical element is located a distance away from an ultraviolet radiation source, and wherein the distance is approximately equal to a diameter of the corresponding ultraviolet radiation source and is configured to increase uniformity of the ultraviolet radiation exiting the reflective cavity;
a feedback component including a sensor configured to acquire fluorescence data corresponding to fluorescent visible radiation emitted from a surface radiated by the illuminator; and
a computer system for operating the plurality of ultraviolet radiation sources based on the fluorescence data.

US Pat. No. 10,245,334

REFRACTION TECHNOLOGY SYSTEM

Richard J. Barrett, Roth...

1. A method for modifying the monoatomic oxygen level in a fluid, comprising:(a) providing a first electrode defining a first conductive surface spaced from a second electrode defining a second conductive surface;
(b) providing a porous divider positioned intermediate the first electrode and second electrode and defining a first fluid treatment chamber with the first conductive surface and a second fluid treatment chamber with the second conductive surface;
(c) providing a positive charge to the first electrode and a negative charge to the second electrode;
(d) flowing an initial fluid having an initial oxidation reduction potential (ORP) value from an inlet to the first chamber and the second chamber via an end cap defining a first fluid inlet to the first chamber and a second fluid inlet to the second chamber, wherein the first fluid inlet is configured to allow a greater volume of fluid per unit time to the first chamber than the second fluid inlet allows to the second chamber, thereby modifying the monoatomic oxygen level of the initial fluid in both chambers; and
(e) collecting positive oxygen fluid having a positive ORP value greater than the initial ORP value from the first chamber and negative oxygen fluid having a negative ORP value lower than the initial ORP value from the second chamber.

US Pat. No. 10,245,325

METHODS AND COMPOSITIONS FOR THE SUSTAINED RELEASE OF CHROMIUM

JDS Therapeutics, LLC, P...

1. A composition comprising:a chromium complex comprising:
an amount of a fast-acting chromium complex; and
an amount of a slow-acting chromium complex; wherein the fast-acting chromium complex is absorbed more quickly by an individual to whom it is administered than the slow-acting chromium complex;
wherein the amount of a fast acting chromium complex and the amount of the slow-reacting chromium complex are formulated to have a molar ratio of chromium between 1:10 and 10:1.

US Pat. No. 10,245,285

BLOOD PLASMA AND PLASMA FRACTIONS AS THERAPY FOR TUMOR GROWTH AND PROGRESSION

Alkahest, Inc., San Carl...

1. A method of treating a subject for thymic cancer, the method comprising:administering an effective amount of a blood plasma product to the subject diagnosed with thymic cancer to treat the subject for thymic cancer.

US Pat. No. 10,245,263

TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE AND METHODS OF USE THEREOF

ArQule, Inc., Burlington...

1. A method of treating chronic lymphoid leukemia, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (I):or a pharmaceutically acceptable salt, tautomer, prodrug, or solvate thereof.

US Pat. No. 10,245,256

NITROXIDES FOR USE IN TREATING OR PREVENTING DIABETES AND OBESITY

Mitos Pharmaceuticals, In...

1. A method of treatment comprising:identifying a subject having elevated TNFa levels, and
administering to the subject an amount of a nitroxide antioxidant effective to reduce said levels in the subject, wherein the nitroxide antioxidant is selected from the following formulas:

wherein X is selected from O— and OH, and R is selected from COOH, CONH2, CN, and CH2NH2;

wherein X is selected from O— and OH, and R1 is CH3, R2 is C2H5, or R1 and R2 taken together are spirocyclohexyl;

wherein X is selected from O— and OH and R is selected from CONH2; and

wherein X is selected from O— and OH and R is selected from H, OH, and NH2, or wherein the nitroxide antioxidant is selected from the group consisting of 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-bromoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(ethoxyfluorophosphonyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-isothiocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(4-nitrobenzoyloxyl)-2,2,6,6-tetramethylpiperidine-1-oxyl, and 4-phosphonooxy-2,2,6,6-tetramethylpiperidine-1-oxyl.

US Pat. No. 10,245,249

PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS

Cardioxyl Pharmaceuticals...

1. A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1)andwherein the composition has a pH of from about 5 to about 6.5.

US Pat. No. 10,245,248

FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO

BACH BIOSCIENCES, LLC, C...

1. A prodrug represented by the general formula
or a pharmaceutically acceptable salt thereof, wherein:R1 represents (C1-C10)alkyl, (C1-C10)alkoxy, (C1-C10)alkyl-C(O)—(C1-C10)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, aryl, aryl(C1-C10)alkyl, heteroaryl, or heteroaryl(C1-C10)alkyl, wherein any R1 is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, carboxylate, cyano, amino, nitro, and thio (—SH); or —C(?X)R1 represents an N-terminally blocked alpha amino acid residue and X is O;R2 represents H or a (C1-C6)alkyl;R3 represents a (C1-C6)alkyl;R4 is absent or represents one, two or three substituents, each independently selected from a (C1-C6)alkyl, —OH, —NH2, or halogen;X represents O or S;Cyt?, or Cyt?L-NH, represents a cytotoxic compound or cytostatic compound, less a hydrogen atom; andL represents a 4- to 8-membered ring which is part of the cytotoxic compound or cytostatic compound and is recognized by FAP as a P?1 residue; or L is a self-immolative linker which is metabolized after FAP cleavage to release Cyt?,wherein the prodrug is selectively converted to the cytotoxic compound or cytostatic compound by FAP+ stromal cells.

US Pat. No. 10,245,247

OMEGA-3 FATTY ACID ARTICLES OF MANUFACTURE, AND METHODS AND APPARATUS FOR MAKING SAME

AMBO INNOVATIONS, LLC, O...

1. An article of manufacture comprising a lipid resulting from a source of omega-3 fatty acids co-processed with a hydrophilic flavonoid, a lipophilic anti-oxidant, and melatonin in a concentration effective to inhibit lipid destroying enzymes.

US Pat. No. 10,245,240

TREATMENT OF PROSTATE CARCINOMA

PELLFICURE PHARMACEUTICAL...

1. A method of inhibiting or delaying the growth of prostate cancer, comprising administering to a human having prostate cancer a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt of Formula (I):
wherein:
R1 is methyl;
R2 is hydrogen;
R3 is —OH;
R4 is hydrogen;
R5 is hydrogen;
R6 is hydrogen; and
wherein the compound of Formula (I) is administered to the human in combination with, subsequent to, or concomitantly with, an androgen deprivation therapy that reduces production of dihydrotestosterone (DHT), androsterone, androstenediol, androstenedione, dehydroepiandrosterone (DHEA), or dehydroepiandrosterone sulfate (DHEA-S); and wherein the growth of prostate cancer is inhibited or delayed.

US Pat. No. 10,245,233

CONTROLLED RELEASE FROM PARTICLES ENCAPSULATED BY MOLECULAR LAYER DEPOSITION

Technische Universiteit D...

8. A method for the production of a slow-release material (1) according to claim 1, the method comprising:fluidizing particles (100) comprising an active component (10) in a reactor (1000), wherein the active component comprises one or more of a pharmaceutical compound and a nutraceutical compound;
applying molecular multi-layer deposition with self-terminating reactions on said fluidized particles (100) in said reactor (1000), wherein sequentially compounds (II) and (III) are reacted:
wherein R1, R2, R3, and R4 are independently selected from the group consisting of a carbon comprising group, wherein R2 is optionally present, wherein A1 and A2 are independently selected from OH, Cl, and —OR5, wherein R5 is selected from the group consisting of a carbon comprising group and a silicon comprising group, wherein Z11 and Z12 are each independently selected from an OH comprising group, an NH comprising group and an NH2 comprising group;removing the thus obtained particles from said reactor (1000), to provide said slow-release material (1).

US Pat. No. 10,245,228

SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN

AcelRx Pharmaceuticals, I...

1. A dosage form for oral transmucosal administration to a subject, comprising: from 5.0 micrograms to 100 micrograms sufentanil, wherein said dosage form is bioadhesive and has a volume of less than 30 microliters or a mass of less than 30 mg, wherein the administration of the dosage form to the subject provides a Tmax with a coefficient of variation less than 40%.

US Pat. No. 10,245,215

PILL CUTTING AND STORAGE DEVICE

Tyson Triplett, Provo, U...

1. An apparatus, the apparatus comprising:a base;
a fixed member attached to the base, the fixed member comprising a first cutting wedge;
a lever arm pivotably attached to one or more of the base and the fixed member at a pivot point, the lever arm comprising a second cutting wedge, the lever arm positionable between an open position and a closed position, wherein the lever arm rotates to move the second cutting wedge to contact the first cutting wedge where a cutting surface of the first cutting wedge aligns with a cutting surface of the second cutting wedge when the lever arm is in the closed position, wherein the cutting surface of the first cutting wedge and the cutting surface of the second cutting wedge are oriented parallel to an axis of rotation of the pivot point, and wherein the base, the fixed member, and the lever arm form, in a closed position, a first compartment on a first side of the first and second cutting wedges and form a second compartment, separate from the first compartment, on a second side of the first and second cutting wedges, the first side opposite the second side, wherein the base forms a bottom to the first and second compartments; and
a cover positionable over only one side of the first and second compartments formed by the base, the fixed member, and the lever arm, wherein the first and second compartments are enclosed when the cover is positioned over the first and second compartments and the lever arm is in the closed position, wherein the cover is separately pivotable from the lever arm.

US Pat. No. 10,245,208

THERAPEUTIC DEVICE

HORSEWARE PRODUCTS LTD., ...

1. A therapeutic device for treating a limb of a human or a non-human animal, the therapeutic device comprising:a wrap having a pocket;
an elongate, flexible panel;
a plurality of recesses formed in the elongate, flexible panel;
a top covering on a top surface of the elongate, flexible panel and a bottom covering on a bottom surface of the elongate, flexible panel;
at least one vibrating source retained in a first recess of the plurality of recesses;
a battery retained in a second recess of the plurality of recesses; and
wires extending between the battery and the at least one vibrating source,
wherein the wrap is configured to be wrapped around a limb, and
wherein the elongate, flexible panel is located within the pocket, the wrap being dimensioned to fit around a part of the limb to be treated.

US Pat. No. 10,245,180

OPHTHALMOLOGICAL DEVICE FOR TREATING EYE TISSUE

Ziemer Ophthalmic Systems...

1. An ophthalmological device for treating eye tissue with laser pulses, comprising:a scanner system for dynamically deflecting the laser pulses;
a projection optical unit for focused projection of the laser pulses in a projection direction;
a zoom system, which is arranged downstream of the scanner system and upstream of the projection optical unit, between the scanner system and the projection optical unit, and which is configured to adjust the focused projection of the laser pulses in the projection direction in different zoom settings, whereby the zoom system has an optical axis and a virtual entry pupil which moves along the optical axis with the different zoom settings; and
a displacement device, which is configured to displace the scanner system along the optical axis of the zoom system depending on the zoom setting of the zoom system, the displacement device comprising a drive coupled to the scanner system and configured to displace the scanner system along the optical axis of the zoom system, and one or more circuits configured to control the drive to displace the scanner system along the optical axis of the zoom system using a current zoom setting of the zoom system, wherein the displacement device is configured to adapt a position of the scanner system, with respect to a current position of the virtual entry pupil of the zoom system, for continuously maintaining a value of distance of the scanner system from the virtual entry pupil of the zoom system.

US Pat. No. 10,245,162

PROSTHESIS INSTALLATION SYSTEMS AND METHODS

Kambiz Behzadi, Pleasant...

1. A vibratory device for installation of a prosthesis into a cavity prepared in a portion of a bone, comprising:an engine producing a motion;
a shaft coupled to the prosthesis;
a converter, coupled to said engine and to said shaft, producing a series of longitudinal vibrations in said shaft and the prosthesis responsive to said motion;
wherein said converter includes a cam having a cam surface responsive to said rotary motion and wherein said shaft is coupled to said cam surface; and
wherein said converter includes a rocker arm coupled between said cam surface and said shaft with a first end of said rocker arm coupled to said cam surface and a second end of said rocker arm coupled to said shaft and wherein a biasing structure is coupled to said second end.

US Pat. No. 10,245,161

ASSEMBLY FOR IMPLANTING AN ACETABULAR CUP IN A COTYLOID CAVITY

Dedienne Sante, Maugio (...

1. An assembly for implanting an acetabular cup in a cotyloid cavity, the assembly comprising:the acetabular cup, intended to be implanted in a cotyloid cavity of a patient's pelvis, and
a gripping and impacting instrument for the acetabular cup, the instrument comprising:
a gripper having a surface to come into contact with the acetabular cup, the gripper includes reversible retaining members for reversibly retaining the acetabular cup, and a gripping/impacting handle;
the acetabular cup has at least two snapping rims;
the gripper is separated from the handle and capable to be assembled to said handle, the gripper comprising a connecting device to the handle;
the handle is a separate subassembly from the gripper and capable to be assembled to the gripper, the handle comprising a connecting piece for connecting to the gripper, capable to cooperate with the connecting device of the gripper to connect said handle to said gripper;
the reversible retaining members are in the form of snapping teeth suitable for engaging with the snapping rims comprised by the acetabular cup and releasing the acetabular cup following a thrust exerted on the acetabular cup along an axis of revolution of that acetabular cup;
the gripper comprises a movable pusher, movable from a withdrawn position not hindering the assembly of the acetabular cup to the gripper, toward an extension position, the pusher exerting, during the movement, thrust on the acetabular cup along the axis of revolution of said acetabular cup, so as to disengage the snapping rims comprised by the acetabular cup from the engagement with the snapping teeth comprised by the gripper;
the assembly comprises actuating devices for actuating the movable pusher, making it possible to move that pusher from said withdrawn position to said extension position;wherein:the connecting device for connecting the gripper to the handle comprises:
an assembly cavity arranged in the gripper and an assembly head secured to the handle, the assembly head forming an extension capable to be received in an adjusted manner in the assembly cavity;
first locking recesses arranged in walls defining said assembly cavity and second locking recesses arranged in side walls of said extension, the first and second recesses coming opposite one another in the assembly position of the gripper to the handle;
a movable locking/thrust part, capable to be moved in said extension, that forms third recesses capable to come opposite said second recesses, and that has flats situated near the third recesses, on the proximal side relative thereto;
an elastically deformable shank or other similar expansive element, engaged and retained in said first recesses or in said second recesses, the shank being deformable between a contracted state, in which does not hinder the engagement and sliding of said extension in said assembly cavity, and a not deformed state, in which extends both in said first recesses and in said second recesses, thus performing a reversible retention of said extension in said assembly cavity and therefore a reversible assembly of the gripper to the handle;
wherein said locking/thrust part being movable between a position not locking the assembly of the gripper to the handle, in which said third recesses are opposite the shank and allow the deformation of said shank in said contracted state, therefore allowing said reversible assembly of the gripper to the handle, and a position locking the assembly of the gripper to the handle, in which said flats comprised by a locking/thrust part are opposite the shank and prohibit the deformation of said shank in said contracted state, therefore locking the assembly of the gripper to the handle;
said movable pusher is situated opposite said assembly cavity; and
the actuating device of the pusher include said locking/thrust part, which is movable between said locking position and a bearing position in which bears against the movable pusher so as to move said pusher toward said extension position.

US Pat. No. 10,245,139

APPARATUS AND METHOD FOR CLAMPING AND TRIMMING THE BONE TENDON OF A GRAFT TO A DESIRED SIZE

KOCO CLAMP, LLP, St. Pet...

1. A method for clamping and trimming a bone tendon portion of a graft to a desired size, comprising the steps of:clamping a pair of jaws the jaws defining a generally U-shaped receptacle about the bone tendon portion of the graft to be trimmed, wherein the jaws comprise respective upstanding, inwardly-sloping sidewalls sloping from a narrower width at a top portion to a wider width at a bottom portion of the jaws to define the generally U-shaped trapezoidal receptacle when the jaws are closed; and
trimming an excess portion of the bone tendon portion protruding from an upper guide surface of the jaws by moving a cutting instrument along the upper guide surface to trim the excess portion of the bone tendon portion protruding outside the upper guide surface.

US Pat. No. 10,245,127

METHOD OF MANUFACTURING MULTILAYER ZIRCONIA BLOCK FOR ARTIFICIAL TEETH

DENTAL MAX CO., LTD., Se...

1. A method of manufacturing a multilayer zirconia block for artificial teeth, comprising:a first material mixing step of mixing a 3 mol % yttrium oxide-tetragonal zirconia polycrystal and an organic binder;
a third material mixing step of mixing a 5 mol % yttrium oxide-tetragonal zirconia polycrystal and the organic binder;
a second material mixing step of mixing the 3 mol % yttrium oxide-tetragonal zirconia polycrystal, the 5 mol % yttrium oxide-tetragonal zirconia polycrystal, and the organic binder, wherein the 3 mol % yttrium oxide-tetragonal zirconia polycrystal and the 5 mol % yttrium oxide-tetragonal zirconia polycrystal are mixed to a predetermined concentration between 3 mol % and 5 mol %;
a compression molding step of sequentially placing mixtures, obtained in the first material mixing step, the second material mixing step, and the third material mixing step, in a mold for compression molding and performing compression molding; and
a calcination step of calcining a compression molded product obtained in the compression molding step.

US Pat. No. 10,245,119

SIGNAL TAG DETECTION COMPONENTS, DEVICES, AND SYSTEMS

Elucent Medical, Inc., E...

1. A system comprising:a) a tag, said tag comprising a radio-frequency identification (RFID) chip and an antenna, wherein said tag emits a sideband at a defined frequency, upon activation by a magnetic field;
b) a remote activation device that generates a magnetic field within a region of the tag;
c) a plurality of witness stations, each said witness station comprising an antenna configured to detect said sideband; and
d) a component that is attachable to a medical device, wherein said component comprises:
i) at least two medical device location emitters, and
ii) an indicator comprising a visual display that presents distance to tag information, and spatial orientation, for said medical device.

US Pat. No. 10,245,118

SIGNAL TAG DETECTION COMPONENTS, DEVICES, AND SYSTEMS

Elucent Medical, Inc., E...

1. A method for localizing a tissue region of a patient, comprising:a) placing a remote activating device and a patient in proximity to each other,
wherein said remote activating device generates a magnetic field, and
wherein said patient comprises a tag at a location in, on, or proximal to a tissue of said patient; and
b) localizing said tag in said patient by generating a magnetic field with said remote activating device and detecting a signal from said tag using a detector component,
wherein said detector component comprises an electronics component and at least one sense coil and is attached to, or integrated with, a surgical device, wherein said electronics component comprises a signal processor, and
wherein said detector component and said remote activating device are separate.

US Pat. No. 10,245,110

DYNAMIC PLANNING METHOD FOR NEEDLE INSERTION

XACT ROBOTICS LTD., Caes...

1. A method of pre-operatively planning an image-guided insertion procedure for inserting a tool into a tissue in a region of interest of a subject, comprising:(a) obtaining a plurality of time-separated images of the region of interest, each image of said plurality of time-separated images derived at a different time during the breathing cycle of said subject;
(b) defining on a first image of said plurality of time-separated images a tissue entry point for entry of said tool into said tissue, a target point and one or more forbidden regions into which entry is forbidden by said insertion procedure;
(c) calculating on said first image a first trajectory for said insertion procedure between said tissue entry point and said target point, which avoids entry into all of said one or more forbidden regions;
(d) determining the positions of said tissue entry point, said target point and said one or more forbidden regions in one or more other images of said plurality of time-separated images;
(e) calculating, for said insertion procedure, on at least one of said one or more other images, at least one new trajectory between said tissue entry point and said target point, which avoids entry into all of said one or more forbidden regions, based on the positions of said tissue entry point, said target point and said one or more forbidden regions in said at least one of said one or more other images, as determined in step (d);
(f) determining if at least one of the entry angle at said tissue entry point and the curvature of any of the calculated first and at least one new trajectories exceeds one or more predetermined levels; and
(g) if said one or more predetermined levels are not exceeded, determining pre-operatively that said calculated first and at least one new trajectories are suitable trajectories for said insertion procedure.

US Pat. No. 10,245,108

APPARATUS AND METHOD FOR PRODUCING VERY SMALL MICROCHANNELS IN TISSUE

LUMENIS LTD., (IL)

1. A method of producing small microchannels on a skin tissue surface while maintaining a 50 mm standoff distance from the skin tissue surface comprising:providing a lens system having:
a plurality of aligned lenses;
one or more scanning mirrors in line with and upstream of the plurality of aligned lenses and a source of laser energy upstream of the one or more scanning mirrors, wherein laser light beam from the laser source is transmitted from the source of laser energy, deflected by the one or more scanning mirrors and then transmitted through the aligned lenses;
a first diverging beam lens of the plurality of aligned lenses downstream of the one or more scanning mirrors having negative refractive power;
a second converging beam lens of the plurality of aligned lenses downstream of the first lens having positive refractive power;
a third converging beam lens of the plurality of aligned lenses downstream of the second lens having positive refractive power; and,
a fourth converging beam lens of the plurality of aligned lenses downstream of the third lens with positive refractive power;
wherein the laser light beam exiting from the laser source is 7 mm in diameter, diverges to 12 mm after being transmitted through the first and the second lenses, enters the third lens with a 12 mm diameter, and converges to 70 microns on the focal plane after being transmitted through the third and fourth lenses;
the method comprising:
transmitting a laser light beam of 7 mm in diameter from the source of laser energy to impinge on the first lens;
transmitting the laser light beam through the first and second lenses, whereby the light beam diverges to 12 mm;
transmitting the diverged light beam to the third lens, the third lens collimating the light beam; and,
transmitting the light beam from the third lens to the fourth lens, the fourth lens converging the light beam to produce 70 micron microchannel spots at a standoff distance of 50 mm from the vertex of the fourth lens at the skin tissue surface.

US Pat. No. 10,245,105

ELECTROPORATION WITH COOLING TO TREAT TISSUE

VIRGINIA TECH INTELLECTUA...

1. A method of treating tissue with electrical energy, the method comprising:performing electroporation of target tissue using one or more electroporation devices comprising one or more electrodes and one or more hollow chambers with a fluid disposed therein; and
flowing the fluid disposed in one or more of the hollow chambers to provide cooling during the electroporation to cause non-thermal cell death of the target tissue.

US Pat. No. 10,245,091

DIP FUSION SPIKE SCREW

ExsoMed Holding Company, ...

1. A bone fusion screw comprising:(a) a first threaded portion having a uniform first diameter, first threads having a first thread pitch and a uniform first thread height, and a driver head; and
(b) a second threaded portion with second threads having a second thread pitch and a second thread height, wherein the second threaded portion tapers from a second diameter to a smaller, third, diameter, wherein the second thread pitch is greater than the first thread pitch and the second thread height is greater than the first thread height; and
(c) a central portion between the first threaded portion and the second threaded portion, wherein the central portion has a uniform diameter.

US Pat. No. 10,245,090

BLADE ANCHOR SYSTEMS FOR BONE FUSION

Engage Medical Holdings, ...

1. A fusion device comprising:a central portion comprising a biconcave leading edge, a blunt trailing end opposite the leading edge, a first lateral end, and a second lateral end opposite the first lateral end;
a first lateral blade transversely mounted to the first lateral end of the central portion, wherein the first lateral blade comprises a tapered first leading point and a first trailing portion opposite the first leading point; and
a second lateral blade transversely mounted to the second lateral end of the central portion, wherein the second lateral blade comprises a tapered second leading point and a second trailing portion opposite the second leading point;
wherein the leading edge and the first and second leading points all face the same way, wherein the trailing end and the first and second trailing portions all face the same way;
wherein the first lateral blade extends outwardly from the leading edge and the trailing end of the central portion so that the leading edge and the trailing end are between the first leading point and the first trailing portion and;
wherein the first lateral blade comprises a first exterior surface and a first interior surface opposite the first exterior surface, wherein the first exterior surface faces away from the central portion, wherein the first interior surface is sloped and intersects the first exterior surface at the first leading point.

US Pat. No. 10,245,088

BONE PLATING SYSTEM AND METHOD

Treace Medical Concepts, ...

1. A bone plate comprising:a body having a length defining a central longitudinal axis extending from a proximal region of the body to a distal region of the body and a width defining an extent of the bone plate transverse to the central longitudinal axis, wherein the body includes a top surface and a bone facing surface opposite the top surface;
a helical curvature between the proximal and distal regions of the body comprising both a bend of the body along the central longitudinal axis and a twist of the body about the central longitudinal axis, wherein the distal region lies in a first plane corresponding to a plantar region of a first bone to which the bone plate is configured to be attached and the proximal region lies in a second plane offset from the first plane both along and about the longitudinal axis such that the helical curvature provides a transition from the first plane to the second plane, the second plane corresponding to a medial region of a second bone to which the bone plate is configured to be attached; and
a first fixation hole in the proximal region and a second fixation hole in the distal region, wherein the first fixation hole and second fixation hole each extend through the body from the top surface to the bone facing surface.

US Pat. No. 10,245,086

BONE PLATING KIT FOR FOOT AND ANKLE APPLICATIONS

Treace Medical Concepts, ...

1. A disposable single-use surgical kit for a foot or ankle orthopedic procedure comprising:a sterile container;
a plurality of unicortical bone plate fasteners included in the sterile container; and
at least one bone plate but no more than four bone plates included in the sterile container, each bone plate comprising:
a body having a top surface and a bone facing surface opposite the top surface; and
a first fixation hole extending through the body from the top surface to the bone facing surface and configured for receiving one of the plurality of unicortical bone plate fasteners included in the sterile container,
wherein at least one bone plate of the at least one but no more than four bone plates comprises the body extending from a proximal region to a distal region and having a helical curvature between the proximal region and the distal region.

US Pat. No. 10,245,084

RESILIANT SPINAL PLATE SYSTEM

Genesys Spine, Austin, T...

1. An orthopedic fusion system comprising:a plate that includes a first aperture;
a single-piece monolithic resilient member; and
a screw including a lip;
wherein:
the plate includes a first cavity, the first cavity directly interfacing the first aperture;
at least a portion of the resilient member is included in the first cavity;
the resilient member includes an arcuate portion, a first resilient member projection, and a second resilient member projection;
the arcuate portion couples the first resilient member projection to the second resilient member projection;
the first resilient member projection projects into the first aperture and towards a center of the first aperture;
the second resilient member projection projects into the first aperture and towards the center of the first aperture;
the screw includes a shoulder, the shoulder being coupled to the lip;
the screw includes a first screw projection and a second screw projection;
the lip is between the first screw projection and the shoulder;
the lip is between the second screw projection and the shoulder;
the system is configured such that in a partially implanted position the screw is included in the first aperture and the shoulder actively deflects the first resilient member projection medially;
the system is configured such that in the partially implanted position the screw is included in the first aperture and the shoulder actively deflects the second resilient member projection laterally;
the system is configured such that in a fully implanted position the screw is included in the first aperture such that the screw is prevented from backing out of the first aperture by the first resilient member projection that has snapped back towards the center of the first aperture to intercept the lip;
the system is configured such that in the fully implanted position the screw is included in the first aperture such that the screw is prevented from backing out of the first aperture by the second resilient member projection that has snapped back towards the center of the first aperture to intercept the lip; and
the system is configured such that in the fully implanted position the screw is allowed to rotate but is prevented from counter-rotating because the first screw projection is lodged against the first resilient member projection.

US Pat. No. 10,245,081

RATCHETED SPINAL DEVICE

Apifix Ltd., Carmiel (IL...

1. A ratcheted spinal device comprising:a length member disposed in a housing, said length member comprising all portions having a length that protrudes out of said housing a variable amount, said length member and said housing comprising a ratchet mechanism that has an operative configuration that allows a change in the length that said length member protrudes out of said housing in one direction, wherein each of said housing and said length member comprises a polyaxial-joint attachment member for attachment to bone, each of said polyaxial-joint attachment members permitting pivoting movement about more than one pivoting axis, and comprising pedicle screws that pass through said polyaxial-joint attachment members, and wherein for each of said pedicle screws a nut firmly holds said pedicle screw in place while still enabling polyaxial rotation of said pedicle screw even after the nut has been fully tightened, wherein teeth of said ratchet mechanism comprise teeth on said length member which are positioned within said housing such that a change in length of said length member does not necessarily cause the teeth on said length member to protrude out of said housing.

US Pat. No. 10,245,074

APPARATUS AND METHODS FOR ACCESSING AND SEALING BODILY VESSELS AND CAVITIES

CrossBay Medical, Inc., ...

1. A method for treating a biological lumen comprising:positioning a balloon adjacent to an opening of the biological lumen, wherein the balloon has a closed distal terminal end, and wherein the balloon is attached to a base comprising a leader;
delivering a pressurized media into the balloon with an inflation device, wherein the delivering comprises everting the balloon into the biological lumen, and wherein the everting comprises occluding the biological lumen;
detaching the inflation device from the balloon; and
pulling the balloon from the biological lumen after the detaching of the inflation device, and wherein pulling the balloon comprises pulling the leader.

US Pat. No. 10,245,059

TOOL AND GRIP DEVICE PROVIDED WITH SAID TOOL

Servocad Microtronics S.L...

1. A tool comprising a pair of jaws interacting with one another by means of actuating means, characterized in that said actuating means comprise a central stationary part and two cam plates arranged such that said plates are facing both sides of the central stationary part, the cam plates being slidable on said central stationary part, the two cam plates being associated with a shaft for driving linear movement, and wherein the jaws are coupled to the central stationary part and the two cam plates, such that during a forward movement of the cam plates, said plates cause a linear movement away from one jaw respective to the other, during a backward movement thereof, said cam plates cause a linear movement for moving one of the jaws closer to the other, wherein each of the cam plates has a pair of linear upper slots and a pair of linear lower slots that converge respectively at a point near a central longitudinal axis of the cam plates, and wherein protuberances projecting from each of the jaws are slidable in the upper and lower slots.

US Pat. No. 10,245,055

DEVICES THAT ALLOW FOR RAPID CHANGE OUT OF ENDOTRACHEAL (ET) TUBES AND RELATED METHODS

Michael A. Olympio, Wins...

1. A tracheal tube device, comprising:a mouthpiece comprising an external port merging into an open internal channel sized and configured to allow an endotracheal tube to extend therethrough into a trachea of a subject, the external port having a perimeter, wherein the mouthpiece also comprises at least one short tube with a cavity residing above the external port; and
a handle holding a cutting member and comprising at least one interlock member that interlocks to the mouthpiece,
wherein the mouthpiece has a monolithic molded body with a rim that allows the handle interlock member to interlock to the mouthpiece to be able to selectively extend in either a right or left laterally extending direction.

US Pat. No. 10,245,054

DEVICES FOR RETRIEVING AN OBSTRUCTION IN A BODILY DUCT OF A PATIENT

HIGHWAY 1 MEDICAL, INC., ...

1. A device for capturing an obstruction in a bodily duct of a patient, the device comprising:a cylindrical body having a circumference and a longitudinal axis and including a plurality of cell structures formed by struts, the plurality of cell structures being of the same size and shape and arranged in diagonal rows around the longitudinal axis, the plurality of cell structures including first, second, third, fourth and fifth cell structures, the first cell structure being surrounded by the second, third, fourth and fifth cell structures and sharing at least one strut with each of the second, third, fourth and fifth cell structures, the plurality of cell structures each includes first, second, third, fourth, fifth and sixth struts, each of the first, second, third, fourth, fifth and sixth struts having a proximal end and a distal end, when the device is cut longitudinally and laid flat on a surface the entirety of at least one of the fifth and sixth struts is straight, the proximal end of the first strut being coupled to the proximal end of the second strut, the distal end of the third strut being coupled to the distal end of the fourth strut, the distal end of the first strut being coupled to the proximal end of the fifth strut, the proximal end of the third strut being coupled to the distal end of the fifth strut, the distal end of the second strut being coupled to the proximal end of the sixth strut, the proximal end of the fourth strut being coupled to the distal end of the sixth strut, the proximal and distal ends of the fifth strut being longitudinally aligned with one another and residing at a first circumferential location, the proximal and distal ends of the sixth strut being longitudinally aligned with one another and residing at a second circumferential location, the second circumferential location being spaced apart from the first circumferential location, when the device is cut longitudinally and laid flat on a surface at least a first portion of each of the first, second, third and fourth struts is curved and at least a second portion of each of the first, second, third and fourth struts is straight; and
a first antenna having a proximal end and a distal end, the cylindrical body coupled to the distal end of the first antenna, when the device is cut longitudinally and laid flat on a surface at least a portion of the first antenna is straight, the at least a portion being longitudinally aligned with the proximal and distal ends of at least one of the fifth struts and/or with the proximal and distal ends of at least one of the sixth struts.

US Pat. No. 10,245,047

UNICOMPARTMENTAL CUSTOMIZED ARTHROPLASTY CUTTING JIGS

Howmedica Osteonics Corpo...

1. A femoral arthroplasty jig for assisting in the performance of a femoral arthroplasty procedure on a femoral arthroplasty target region of a femur of a patient, the femur including an intercondylar notch, an articular condyle surface, an articular trochlear groove surface, and an area between an articularis genu and a patellar facet boarder on an anterior side of a femoral shaft, the articular condyle surface including a medial articular condyle surface and a lateral articular condyle surface, the articular trochlear groove surface including an anterior-proximal trochlear groove surface with an anterior-proximal edge, the jig comprising:a mating surface including a customized surface contour that is a negative of certain surfaces of the femoral arthroplasty target region, the mating surface configured to matingly receive and contact the certain surfaces of the femoral arthroplasty target region, the certain surfaces including the articular condyle surface, the articular trochlear groove surface, and at least one contact point on the anterior-proximal edge of the anterior-proximal trochlear groove surface, the certain surfaces not including the intercondylar notch,
wherein a portion of the mating surface configured to matingly receive and contact the at least one contact point comprises at least one hooking point configured to contact a proximal portion of the anterior-proximal edge of the anterior-proximal trochlear groove surface.

US Pat. No. 10,245,042

CHECK VALVE VENTED STERILIZABLE POWERED SURGICAL HANDPIECE

Medtronic Xomed, Inc., J...

1. A surgical handpiece comprising:a housing defining an interior cavity and defining a handle configured to be grasped by a user;
a motor assembly disposed within the handle, the motor assembly including a motor not rated for steam sterilization;
a drive shaft disposed through the housing;
an adapter coupled to the drive shaft and the housing, the adapter configured to couple a surgical tool to the handpiece; and
a check valve assembly including a check valve cartridge and a check valve, the check valve cartridge having walls extending into the interior cavity and defining a valve cavity, the check valve cartridge coupled to the housing and disposed internal to the housing, the check valve cartridge sealed to the housing via a press fit and including a seal disposed circumferentially about the check valve cartridge, the check valve disposed within the check valve cartridge, the check valve having an open state and a closed state, the check valve configured to provide fluid communication between the interior cavity and ambient air outside of the housing in the open state and prevent fluid communication between the interior cavity and ambient air outside of the housing in the closed state,
wherein the housing defines an open channel extending between the valve cavity and an exterior surface of the housing, and
wherein the housing, the motor assembly, the drive shaft adapter, and the sterilization check valve assembly are configured to be sterilizable and withstand steam sterilization in an assembled state of the surgical handpiece, and the sterilization check valve assembly is configured to be in an open state during steam sterilization.

US Pat. No. 10,245,020

METHODS AND SYSTEMS FOR KNOTLESS SUTURE ANCHORING

MEDOS INTERNATIONAL SARL,...

1. A method of performing a surgical repair, comprising:distally driving an anchor assembly comprising a proximal anchor body mated to a proximal end of a distal anchor body of the anchor assembly into a hole in a bone, the proximal anchor body having at least one suture passed through at least one opening formed through at least one side wall of the proximal anchor body, the suture being passed through the opening such that terminal end portions of the suture pass alongside a driver shaft removably attached to the anchor assembly, the suture having a portion thereof that is attached to soft tissue;
and rotating the distal anchor body to cause the distal anchor body to move proximally towards the proximal anchor body such that a proximal portion of the distal anchor body is received within the proximal anchor body so as to occlude the opening and thereby cause the suture to be secured between an inner wall of the proximal anchor body and an outer wall of the distal anchor body.

US Pat. No. 10,245,018

METHOD AND APPARATUS FOR CLOSING FISSURES IN THE ANNULUS FIBROSUS

Suture Concepts Inc., Ba...

1. A method for closing a fissure in a region of tissue having an inner surface and an outer surface, the method comprising:providing a first transverse anchor having a first surface, a second surface and a hole extending from the first surface to the second surface, and a first flexible longitudinal fixation component having a first end and a second end, wherein the first flexible longitudinal fixation component is passed through the hole in the first transverse anchor and secured to the first transverse anchor with a first knot tied on the second surface of the first transverse anchor;
providing a second transverse anchor having a first surface, a second surface and a hole extending from the first surface to the second surface, and a second flexible longitudinal fixation component having a first end and a second end, wherein the second flexible longitudinal fixation component is passed through the hole in the second transverse anchor and secured to the second transverse anchor with a second knot tied on the second surface of the second transverse anchor;
positioning the first surface of the first transverse anchor on one side of the fissure and against the inner surface of the tissue, with the second end of the first flexible longitudinal fixation component extending to the outer surface of the tissue on the first side of the fissure;
positioning the first surface of the second transverse anchor on the second side of the fissure and against the inner surface of the tissue, with the second end of the second flexible longitudinal fixation component extending to the outer surface of the tissue on the second side of the fissure;
tensioning the first flexible longitudinal fixation component and second flexible longitudinal fixation component so as to reduce the size of the fissure; and
securing the first flexible longitudinal fixation component to the second flexible longitudinal fixation component.

US Pat. No. 10,245,016

ADJUSTABLE SELF-LOCKING LOOP CONSTRUCTS FOR TISSUE REPAIRS AND RECONSTRUCTIONS

ARTHREX, INC., Naples, F...

1. A fixation system for tissue reconstruction, comprising: a fixation device;a knotless tensionable loop construct attached to the fixation device and having two flexible loops and two splices, at least one of the two flexible loops having an adjustable length, wherein the two flexible loops are interlinked such that a first loop of the two flexible loops passes through an opening established by a second loop of the two flexible loops and the second loop passes through an opening established by the first loop wherein the two flexible loops and the two splices are formed from a same flexible strand; and
a graft connected to the tensionable loop construct, wherein at least one of the two flexible loops is passed through a bone block of the graft wherein a region where the two flexible loops are interlinked is located within a hole of the bone block.

US Pat. No. 10,245,015

RETRACTOR WITH MODULAR TAP ASSEMBLIES

Life Spine, Inc., Huntle...

1. A retractor assembly, comprising;an elongated base having a first side including a first plurality of teeth and a first elongated through slot extending along a first direction, and a second side including a second plurality of teeth and a second elongated through slot extending along the first direction;
a first side arm assembly coupled to the first side of the base and configured to translate along the base in the first direction, the first side arm assembly including:
a first arm portion including a cavity receiving the first side of the base therethrough, and including a first ratchet mechanism configured to engage the first plurality of teeth;
a second arm portion coupled to the first arm portion of the first arm assembly and extending along a first longitudinal axis perpendicular to the first direction such that the second arm portion is rotatable about the first longitudinal axis relative to the first arm portion, wherein the second arm portion of the first side arm assembly includes a first recess having a closed superior end closed by a top side of the second arm portion of the first side arm assembly and an inferior open end opening through a bottom side of the second arm portion of the first side arm assembly; and
a first locking knob extending through the closed superior end of the second arm portion;
a first side blade assembly having a first attachment arm configured to be received in the first recess of the first side arm assembly only from the bottom side of the second arm portion of the first side arm assembly of the retractor assembly such that the first locking knob threadingly engages a locking aperture of the first attachment arm of the first side blade assembly, the first side blade assembly further includes a first tap assembly including a first threaded screw configured to threadingly engage bone;
a second side arm assembly coupled to the second side of the base and configured to translate along the base in the first direction independent from the first side assembly, the second side arm assembly including:
a first arm portion including a cavity receiving the second side of the base therethrough, and including a second ratchet mechanism configured to engage the second plurality of teeth;
a second arm portion coupled to the first arm portion of the second side arm assembly and extending along a second longitudinal axis perpendicular to the first direction such that the second arm portion of the second side arm assembly is rotatable about the second longitudinal axis relative to the first arm portion of the second side arm assembly, wherein the second arm portion of the second side arm assembly includes a second recess having a closed superior end closed by a top side of the second arm portion of the second side arm assembly; and an inferior open end opening through a bottom side of the second arm portion of the second side arm assembly; and
a second locking knob extending through the closed superior end of the second arm portion of the second side arm assembly;
a second side blade assembly having a second attachment arm configured to be received in the second recess of the second side arm assembly only from the bottom side of the second arm portion of the second side arm assembly of the retractor assembly such that the second locking knob threadingly engages a locking aperture of the second attachment arm of the second side blade assembly, the second side blade assembly further includes a second tap assembly including a second threaded screw configured to threadingly engage bone;
a center arm assembly having a first portion removably coupled to a center portion of the base between the first and second sides of the base, and a second portion of the center arm assembly is configured to translate relative to the base and through the first portion of the center arm assembly along a second direction different from the first direction, the second portion of the center arm assembly includes a center recess opening through a top side of the second portion of the center arm assembly;
a center blade assembly having a center attachment arm configured to be removably coupled into the center recess of the second portion of the center arm assembly only from the top side of the second portion of the center arm assembly of the retractor assembly, wherein the center blade assembly includes a second blade received by a first blade coupled to the center arm assembly; and
a locking screw configured to threadingly engage the top side of the second portion of the center arm assembly and having a head including a cutout configured for rotation to be aligned with the center recess to allow coupling the center attachment arm in the center recess of the center arm assembly and configured for rotation to be unaligned with the recess to retain the center attachment arm in the center recess of the center arm assembly.

US Pat. No. 10,245,010

ASSEMBLY FOR COUPLING POWERED DRIVER WITH INTRAOSSEOUS DEVICE

TELEFLEX MEDICAL DEVICES ...

1. A coupler assembly operable to releasably engage one end of a drive shaft extending from a powered driver with an intraosseous (IO) device having a first end operable to penetrate a bone and associated bone marrow, the coupler assembly having a first end and a second end, the coupler assembly comprising:an elongated core having a first end operable to be releasably engaged with a second end of the IO device;
the elongated core having a second end operable to be releasably engaged with the one end of the drive shaft extending from the powered driver;
a housing assembly having a first end and a second end with respective openings formed in the first end and the second end of the housing assembly;
the openings in the first end and the second end of the housing assembly each having dimensions and configurations selected to be compatible with exterior portions of the elongated core disposed within the housing assembly;
a biasing mechanism disposed between an interior shoulder of the housing assembly and an exterior shoulder of the elongated core, where the biasing mechanism is operable to bias a first portion of the housing assembly and a second portion of the housing assembly to a first position, where the first end of the housing assembly is closer to the first end of the elongated core when the first portion of the housing assembly is in the first position than in a second position, and where the second end of the housing assembly is closer to the second end of the elongated core when the second portion of the housing assembly is in the first position than in the second position;
a first receptacle disposed in the first end of the elongated core at a location corresponding with the first end of the coupler assembly; and
a second receptacle disposed in the second end of the elongated core at a location corresponding with the second end of the coupler assembly,
where the first portion of the housing assembly is configured to slide along a longitudinal length of the core between the first position and the second position,
where the second portion of the housing assembly is configured to slide along a longitudinal length of the core between the first position and the second position,
where the second portion of the housing assembly is configured to slide over the elongated core relative to the first portion of the housing assembly, and
where the first end of the elongated core has an outer diameter that is greater than an outer diameter of the second end of the elongated core.

US Pat. No. 10,245,008

BODILY FLUIDS SPECIMEN COLLECTION DEVICE

Susan D. Paige, Harrison...

1. A bodily fluids sample collection device, comprising:(a) An elastic elongated frame member comprising: a first end and an opposing second end, the first end and the opposing second end each having a handle, the elastic elongated frame member being planar from the first end to the opposing second end;
(b) The elastic elongated frame member further comprising: a top edge, a first frame side and an opposing second frame side, the first frame side and the opposing second frame side concurrently angling inward from the first end and the opposing second end, respectively, from each handle toward a cup securing region centrally located in the elastic elongated frame member, and the elastic elongated frame member thereby having an increasingly narrowing frame width between the first frame side and the opposing second frame side toward the cup securing region, and a bodily fluids sample cup disposed in an upright position between the first frame side and the opposing second frame side of the elastic elongated frame member for receiving a bodily fluids sample from a patient;
(c) the first frame side and the opposing second frame side at the cup securing region each having an opposing, flexibly adjustable semi-circular cup holding portion, comprised of a pair of opposing semi-circular cup holding portions, defining the cup securing region of the elastic elongated frame member, the first frame side and the opposing second frame side being flexibly adapted to securely and removably engage, receive and support the bodily fluids sample cup;
(d) the first frame side and the opposing second frame side at the cup securing region being flexibly adapted for easy placement and release of the bodily fluids sample cup by the patient;
(e) a toilet bowl;
(f) the elastic elongated frame member having a frame length extending beyond an edge of the toilet bowl;
(g) the toilet bowl having a major axis and a minor axis; and
(h) whereby the handles enable the patient to grasp the bodily fluids sample collection device.

US Pat. No. 10,245,007

HIGH RESOLUTION INTRAVASCULAR ULTRASOUND IMAGING SYSTEMS AND METHODS

InfraReDx, Inc., Burling...

8. A method for obtaining a high resolution intravascular ultrasound image using a high resolution intravascular ultrasound imaging system having an image processor and a catheter configured for percutaneous insertion into a target blood vessel, said method comprising:a. energizing, by a pulser of said image processor, said ultrasonic transducer with a multi-frequency waveform signal,
b. emitting, by said ultrasound transducer, ultrasound energy towards said target blood vessel based on said multi-frequency waveform signal,
c. receiving, by said ultrasound transducer, ultrasound energy reflected from said target blood vessel,
d. decomposing, by a receiver of said image processor, received ultrasound energy into a plurality of individual subband signals,
e. individually processing, by said receiver of said image processor, said plurality of subband signals, and
f. composing, by said receiver of said image processor, said high resolution intravascular ultrasound image by non-linearly combining said individually processed plurality of subband signals.

US Pat. No. 10,244,996

FLUOROSCOPY OPERATOR PROTECTION DEVICE

Radiaction Ltd, (IL)

1. A method for performing fluoroscopy with radiation protection, said method comprising:providing an X-ray source and an X-ray detector/image intensifier mounted on a C-arm adjacent a procedure table;
positioning a first end of a first radiation shield around the X-ray source and conforming a second end of the first radiation shield to the procedure table and/or a body of a patient on the procedure table;
positioning a first end of a second radiation shield around the X-ray detector/image intensifier and conforming a second end of the second radiation shield to the procedure table and/or a body of a patient on the procedure table; and
directing x-rays from the x-ray source through the body of the patient to the X-ray detector/image intensifier while the patient lies on the procedure table within the C-arm, wherein the first radiation shield and the second radiation shield block stray radiation being emitted beyond the patient's body.

US Pat. No. 10,244,989

METHOD AND SYSTEM FOR DETECTING CARDIAC TAMPONADE IN A PATIENT

Egbert Jan Constant Ottev...

14. A method of indicating an occurrence probability for cardiac tamponade in a patient, the method comprising:determining a measured transmural pressure difference between a right atrium pressure measured in a right atrium of the patient, and an intra-pericardial pressure measured in a portion of an intra-pericardial space of the patient,
determining a measured right atrium pressure difference between the measured right atrium pressure and a reference pressure measured at a reference location outside the right atrium and the intra-pericardial space,
comparing the measured transmural pressure difference with a predetermined statistical distribution of predetermined transmural pressure differences versus occurrence probabilities for cardiac tamponade, wherein the predetermined transmural pressure differences are predetermined differences between the right atrium pressure and the intra-pericardial pressure,
determining the occurrence probability for cardiac tamponade, based on said comparing the measured trans-mural pressure difference with a predetermined statistical distribution, and refined by differentiating between a first type of tamponade if the measured right atrium pressure difference is above a predetermined right atrium pressure threshold, and a second type of tamponade if the measured right atrium pressure difference is below the right atrium pressure threshold, and
indicating the determined occurrence probability for cardiac tamponade on an output device configured for outputting the determined occurrence probability for cardiac tamponade to a user.

US Pat. No. 10,244,982

DETECTION OF HARD AND SOFT TISSUE MASS/DENSITY

Achaemenid, LLC, Stratfo...

1. An apparatus for measuring hard and/or soft tissue abnormalities incidental to dental and/or systemic disease, comprising:a stent selected to overlay a patient's hard and/or soft tissue, wherein the stent comprises a plurality of detection ports positioned along the stent, the plurality of ports being selected for positioning adjacent differing density found in the hard and/or soft tissue of the patient; and
a diagnostic device configured for transmitting and receiving non-ionizing electromagnetic waves to measure the patient's hard and/or soft tissue abnormalities associated with the underlying hard and/or soft tissue adjacent the plurality of detection ports, wherein
the diagnostic device comprises wires connected to at least a portion of the plurality of ports at a first end and the wires being connected to a computer at a second end, the wires being configured for transmitting the electromagnetic waves and receiving data associated therewith, and the computer configured for calculating, from the received data, the bone density and/or bone vascular perfusion adjacent and across each of the plurality of ports,
the computer is configured to produce three-dimensional images for mapping surgical procedures, and
at least a pair of the plurality of detection ports comprising a buccal-side detection port and a lingual-side detection port, the lingual-side detection port being positioned opposite the buccal-side detection port, the pairs of detection ports being positioned along an edge of the stent.

US Pat. No. 10,244,981

SKIN TEST IMAGE ANALYSIS APPARATUSES AND METHODS THEREOF

SENSIVIDA MEDICAL TECHNOL...

1. An apparatus for skin testing comprising:a housing with an opening configured to define a field of view of a skin testing region during use;
a test cartridge configured to be removably inserted into the housing, the test cartridge comprising a plurality of microneedles, wherein each of the plurality of microneedles is spaced one millimeter to fifteen millimeters apart from at least one other microneedle in the plurality of microneedles to generate a corresponding plurality of allergy test sample sites spaced one millimeter to fifteen millimeters apart in the field of view of the skin testing region, wherein the housing has an actuator apparatus integrated within the housing to manage actuation of the test cartridge within the opening of the housing when the test cartridge is removably inserted into the housing;
an image sensing apparatus positioned with respect to the housing to capture one or more images in the field of view provided by the opening in the housing;
an illumination apparatus positioned with respect to the housing to direct light towards at least a portion of the field of view provided by the opening in the housing;
a binding apparatus having one or more straps configured to detachably secure the housing to a body area having a circumference with the opening over the skin testing region and a band extending from the one or more straps and around the housing and the image sensing apparatus configured to apply pressure around the circumference of the body area and to a skin surface proximate the skin testing region to constrain movement of the opening over the skin testing region and to maintain a substantially fixed optical distance and spatial registration between the image sensing apparatus and the skin testing region; and
an image processing controller configured to execute one or more programmed instructions comprising:
obtaining, from the image sensing apparatus, a baseline image of the skin testing region prior to an assessment image of the skin testing region including the two or more allergy test sample sites of the corresponding plurality of allergy test sample sites generated by the plurality of microneedles of the test cartridge;
generating a difference image between the baseline image and the assessment image; and
analyzing the two or more allergy test sample sites of the corresponding plurality of allergy test sample sites generated by the plurality of microneedles of the test cartridge based on the difference image to provide a skin test result for each of the two or more allergy test sample sites based on the analysis.

US Pat. No. 10,244,980

LARGE INTESTINE CONTENTS' DIAGNOSIS AND ACOUSTIC CHARACTERIZATION

HYGIEACARE, INC, Austin,...

1. A method comprising:introducing water controllably into a large intestine of a patient,
sensing, by at least one acoustic sensor, acoustic signals at an abdomen of the patient, and
deriving, from the sensed acoustic signals and by a data processing unit, large intestine diagnostic characteristics relating to the patient's large intestine by analyzing the sensed acoustic signals associated with the water introduction
wherein the derived large intestine diagnostic characteristics provide gastrointestinal diagnosis of the patient.

US Pat. No. 10,244,978

METHOD FOR ASSESSMENT OF CEREBROVASCULAR REGULATION

Brain Check Medical, LLC,...

1. A system for detecting and diagnosing potential dysfunction of cerebral autoregulation (CAR) comprising:a headset, the headset containing:
an oximetry sensor, the oximetry sensor configured to detect and measure cerebral oxygen concentration and provide cerebral oxygen concentration measurements over a period of time in the form of cerebral oxygen concentration signals; and
a pressure sensor, the pressure sensor configured to detect and measure arterial blood pressure and provide arterial blood pressure measurements over the period of time in the form of arterial blood pressure signals,
the headset is configured such that when placed on a patient's head the oximetry sensor is positioned over the patient's forehead and the pressure sensor is positioned over a region of the patient's head corresponding to the location of the patient's superficial temporal artery;
the headset in communication with:
a signal processor, the signal processor configured to receive cerebral oxygen concentration signals and arterial blood pressure signals and generate a cross-correlation result representative of lead time between the cerebral oxygen concentration signals and the arterial blood pressure signals; to identify and define a cerebral oxygen concentration waveform based on the cerebral oxygen concentration signals and an arterial blood pressure waveform based on the arterial blood pressure signals, wherein each waveform comprises a beginning minimum value, a rising segment, a maximum value and a decreasing segment, the rising segment being an episode of interest; and to determine a dysfunction of CAR when the cross-correlation result indicates a similarity of pattern between episodes of interest in the waveforms; and
a display, the display configured to display the cerebral oxygen concentration waveform and the arterial blood pressure waveform, the display also configured to display the cross-correlation result and the dysfunction of CAR.

US Pat. No. 10,244,976

DEVICE FOR MEASURING MUSCLE SIGNALS

FIBRUX OY, Vimpeli (FI)

1. A system for guiding a user in an exercise, the system comprising at least one processor, memory including computer program code, and at least one sensor configured to detect a signal from a muscle of the user, the memory and the computer program code configured to, with the at least one processor, cause the system to perform at least the following:measure the signal from the muscle provided by the sensor to obtain a muscle activation signal during at least one contraction of said muscle;
convert said muscle activation signal from the time domain to the frequency domain to obtain a muscle activation spectrum;
determine a first band and a second band from the muscle activation spectrum measured during a maximum voluntary contraction of the muscle;
determine first reference power values for said first band and said second band from the muscle activation spectrum that is measured during the maximum voluntary contraction;
use said first reference power values in determining a ratio of signal characteristics from said first band and said second band of said muscle activation spectrum;
determine a muscle state indicator from said muscle activation spectrum by using said ratio of signal characteristics from the first band and the second band of said muscle activation spectrum; and
guide the exercise using the determined muscle state indicator.

US Pat. No. 10,244,973

SYSTEMS, DEVICES, AND METHODS FOR BODILY FLUID SAMPLE TRANSPORT

Theranos IP Company, LLC,...

1. A method comprising:collecting a bodily fluid sample on a surface of a subject, wherein the collected sample is stored in one or more sample vessels each having an information storage unit on a bottom surface of each of the sample vessels;
providing a transport container to house at least two or more sample vessels, wherein the vessels are arranged in a two-dimensional array configuration in the transport container and wherein the transport container further comprises a tray sized to fit inside the transport container and hold the sample vessels therein in the two-dimensional array configuration;
arranging to have the sample vessels shipped in the transport container from a first location to a second location,
wherein each of the sample vessels arrives at the second location holding a majority of its bodily fluid sample in a non-wicked, non-matrixed form that is removable from the sample vessels in liquid form and wherein the amount of sample in each of the sample vessels does not exceed about 2 ml;
removing the tray from the transport container; and
scanning information storage units on substantially all of the sample vessels, wherein the scanning occurs while the sample vessels remain in the tray in the two-dimensional array configuration at the second location;
wherein the sample vessels held in slots in the tray, wherein said slots have open bottoms that allow said information storage units to be scanned from below after the tray is removed from the transport container.

US Pat. No. 10,244,966

BLOOD VESSEL SIZING DEVICE

SIZER LLLC, St. Charles,...

1. A blood vessel sizing device, comprising:a planar base structure having a front surface and a back surface, wherein the base structure is:
configured to remain substantially rigid and planar when placed on a user's skin to capture a target area of a patient having a vessel; and
substantially transparent to light having a wavelength in the visible spectrum;
a plurality of radiopaque, concentric-circle elements positioned on the base structure;
a plurality of radiopaque and machine-readable symbols positioned on the front surface of the base structure, wherein each symbol of the plurality of symbols represents a dimensional property of at least one of the concentric-circle elements, wherein the concentric-circle elements are configured to be detected by radiological imaging equipment to enable a determination of a size of the vessel without errors of parallax; and
an adhesive layer on the back surface of the planar base structure, configured to adhere the device to an area of skin of the patient.

US Pat. No. 10,244,956

STIMULATION NEEDLE APPARATUS AND METHOD

NUVECTRA CORPORATION, Pl...

1. A stimulation needle apparatus for selectively administering a trial stimulation to body tissue of a patient, the stimulation needle apparatus comprising:a cannula assembly including:
a cannula including a cannula lumen extending along a longitudinal axis from a proximal cannula end to a distal cannula end; and
a cannula hub disposed at the proximal cannula end, wherein the cannula lumen is accessible through the cannula hub; and
a stylet assembly including:
a stylet sized and shaped to fit within the cannula lumen, the stylet including a proximal stylet end and a distal stylet end;
a stylet hub disposed at the proximal stylet end, the stylet hub being configured to engage with the cannula hub, wherein, with the stylet hub engaged with the cannula hub, the distal stylet end extends distally from the distal cannula end; and
a stylet connection electrically coupled with the stylet, the stylet connection extending from a proximal portion of the stylet hub along the longitudinal axis and is fixed onto, and in direct physical contact with, the stylet hub, wherein the stylet connection includes a conductive loop that is configured to electrically and mechanically couple with a test clip of a stimulator device, wherein, with the stimulator device electrically coupled to the stylet connection, a stimulation pulse delivered by the stimulator device is conducted from the stylet connection through the stylet to the distal stylet end to administer the trial stimulation.

US Pat. No. 10,244,954

IMPLANTABLE BIO-PRESSURE TRANSPONDER

Arkis Biosciences Inc., ...

27. An implantable pressure sensor system for the measurement of fluid pressures within a body, the system comprising:a pressure sensor configured to produce a calibrated inlet pressure signal proportionate to a sensed inlet pressure, the pressure sensor being configured to sense the inlet pressure via an inlet pressure port, and to sense a reference pressure of a reference chamber via a reference pressure port, wherein the pressure sensor is configured to selectively sense the inlet pressure and the reference pressure so as to compare the reference pressure to the inlet pressure to generate the calibrated inlet pressure signal;
encoding circuitry configured to receive the calibrated inlet pressure signal from the pressure sensor and to modulate a communications alternating current frequency to produce a sensor information signal;
a sweep generator unit, an oscillator, and a signal delay unit, the sweep generator unit outputs a ramp signal to be compared to the calibrated inlet pressure signal, and the signal delay unit is connected to the sweep generator and the oscillator to delay starting of the oscillator and the sweep generator for a sufficient amount of time to facilitate settling of the pressure sensor; and
a telemetry unit configured to receive electromagnetic transcutaneous powering and to transmit the sensor information signal to a receiver unit external to the body;
wherein the pressure sensor, encoding circuitry, sweep generator unit, oscillator, signal delay unit, and telemetry unit are configured to be implanted in a subcutaneous manner in the body.

US Pat. No. 10,244,949

HEALTH MONITORING SYSTEMS AND METHODS

RHYTHM DIAGNOSTIC SYSTEMS...

1. A method for determining a health parameter including one or more of detecting heart beats or determining pulse oxygenation; the method comprising one or more of:a) detecting heart beats;
using ECG,
using green or another wavelength, or
using a weighted combination of wavelengths;
b) determining pulse oxygenation through generating one or more of a first pulse shape template or a dataset representing a first pulse shape, including using:
green wavelengths,
an ensemble average of green over approximately the same amount of time as for either red or IR,
an ensemble average of multiple wavelengths over approximately the same amount of time as for either red or IR, or
an ensemble average of multiple wavelengths over significantly longer than the amount of time as for either red or IR; or
a long time average of a single wavelength of any color;
c) obtaining a red pulse shape template or dataset representing same and an IR pulse shape template or dataset representing same, and comparing these or one or the other or each of these to the first pulse shape template; and,
d) correlating via linear regression between a red ensemble average with a first pulse shape template or dataset to an IR ensemble average with the first pulse shape template or dataset, where the ratio of these correlations is then used as the AC ratio for oxygen saturation.

US Pat. No. 10,244,948

STATISTICAL HEART RATE MONITORING FOR ESTIMATING CALORIE EXPENDITURE

1. A method of calibrating a fitness tracking device for calorie estimation for a specific exercise session, the method comprising:determining, by a wearable computing device, a start of an exercise session associated with a user of the wearable computing device, the wearable computing device including a processor, a memory, a heart rate sensor, and at least one of a motion sensing module, a display module, and an interface module;
in response to determining the start of the exercise session, measuring, by the heart rate sensor of the wearable computing device, heart rate data (HR) for a first period of time, the first period of time following the start of the exercise session;
determining, by the processor of the wearable computing device, an onset heart rate value of the user based on the measured heart rate data, the onset heart rate value associated with a lowest valid heart rate measured during the first period of time, the onset heart rate value being different from a calibrated resting heart rate (RHR) for the user stored in the memory;
associating, by the processor of the wearable computing device, an RHR parameter of a calorimetry model to the onset heart rate value to calibrate the wearable computing device for the exercise session; and
estimating, by the processor of the wearable computing device, energy expenditure of the user during a second period of time based on the calorimetry model and a plurality of heart rate measurements (HR) obtained by the wearable computing device during the second period of time, the second period of time associated with a portion of time after the first period of time and prior to an end of the exercise session.

US Pat. No. 10,244,945

SYSTEM FOR RECONSTRUCTING SURFACE MOTION IN AN OPTICAL ELASTOGRAPHY SYSTEM

Tiro Medical Limited, Ch...

1. A system for analyzing surface motion of body tissue of a subject with optical elastography comprising:a controller device that controls a vibration unit capable of stimulating a body tissue of a subject by an actuator that vibrates the body tissue, a plurality of cameras, a strobe light, and a computational device which processes image data from the plurality of cameras, wherein surface motion of body tissue is analyzed by capturing a set of images at a plurality of time-steps of a surface of a region of stimulated tissue with the plurality of cameras distributed about the tissue;
developing a 3D surface model of the tissue region from the set of images captured at the plurality of time-steps;
estimating the surface motion of the vibrating body tissue region between time-step images;
estimating a 3D surface motion of the vibrating body tissue region by combining the 3D surface model with the estimated tissue surface motion between time-step images; and
analyzing the 3D surface motion to identify abnormalities in the motion of the vibrating body tissue region.

US Pat. No. 10,244,933

OTOSCOPE AND OTOSCOPIC METHOD BASED ON SPECTRAL ANALYSIS

Helen of Troy Limited, B...

1. A method of automatically identifying or locating an eardrum in a subject's outer ear, by means of an otoscope device, comprising the steps:providing an otoscope including:
a head portion configured to be introduced in an ear canal of the subject's outer ear, the head portion including an electronic imaging unit operable to capture at least one image of the subject's outer ear including the eardrum;
an electronic and/or optic processing unit operable to determine spectral information; and
at least one source of radiation connected to and controlled by the electronic and/or optic processing unit, the at least one source of radiation configured for emitting blue light and/or UV radiation;
introducing the head portion including the electronic imaging unit into the ear canal of the subject's outer ear;
introducing the at least one source of radiation into the ear canal and radiating the ear canal by means of the at least one source of radiation;
capturing at least one image of the subject's outer ear including the eardrum, by means of the electronic imaging unit, based on reflected radiation of radiation emitted by the at least one source of radiation;
determining and analyzing spatially resolved spectral information by means of the electronic and/or optic processing unit; and
automatically identifying or locating the eardrum by means of the electronic and/or optic processing unit in the at least one image by distinguishing the eardrum from surrounding tissue based on a specific amount of blue components and/or UV components within the at least one image of the subject's outer ear.

US Pat. No. 10,244,929

IN VIVO CAMERA WITH MULTIPLE SOURCES TO ILLUMINATE TISSUE AT DIFFERENT DISTANCES

Capso Vision, Inc., Sara...

1. A device comprising:a plurality of emitters of electromagnetic radiation enclosed within a housing, the housing comprising a tubular wall, said plurality of emitters being located in a ring around a camera;
an optical element enclosed within said housing, the optical element being located in a path of a portion of electromagnetic radiation emitted by at least one emitter in the plurality of emitters so as to direct at least a first fraction of said portion of electromagnetic radiation out through the housing, at least a portion of the optical element being on a first side of a lateral plane and said at least one emitter being on a second side of the lateral plane, wherein the optical element comprises a concentrator shaped to reduce angular divergence of at least said portion of electromagnetic radiation;
wherein all electromagnetic radiation from said at least one emitter is emitted on the second side of the lateral plane;
wherein the lateral plane is perpendicular to a longitudinal axis of the housing, the housing having a dimension along the longitudinal axis larger than any dimension within the lateral plane;
wherein the camera is positioned within the housing such that at least a portion of an image is formed in said camera by at least a second fraction of said portion of electromagnetic radiation entering through the tubular wall on the first side of the lateral plane after reflection outside the housing.

US Pat. No. 10,244,928

COMPACT ENDOSCOPE TIP AND METHOD FOR CONSTRUCTING SAME

Cogentix Medical, Inc., ...

1. An endoscope tip comprising:an external housing defining a lens mounting portion at a distal end, said lens mounting portion configured as a first lumen having an internal surface therewithin, wherein the internal surface defines an obstructive feature defining a narrowest diameter of the lens mounting portion, the external housing further defining at least a second lumen separate from the lens mounting portion, the second lumen suitable for one of a working channel, a fluid channel or carrying a light guiding fiberoptic bundle; and
an optical element assembly positioned within said lens mounting portion comprising a first component, a final component and one or more intermediate components, said components comprising at least one light-transmissive element and at least one spacer in direct contact with the internal surface of the lens mounting portion,
wherein said final component is a spacer that is not a lens and the spacer abuts the obstructive feature defined by the internal surface of the lens mounting portion,
wherein at least said first component is glued directly on said internal surface of said first lumen and prevents distal movement of the intermediate components,
wherein said first component and obstructive feature are configured to maintain said intermediate components fixed in position within said lens mounting portion without a lens tube configured to hold, organize or contain said optical element assembly; and
wherein the endoscope tip has a diameter between 2 mm and 4 mm.

US Pat. No. 10,244,914

POLISHING OR GRINDING PAD ASSEMBLY

Husqvarna Construction Pr...

1. A pad assembly comprising:(a) a fibrous and flexible pad including an upper surface, a floor-facing lower surface and a circular peripheral surface, the floor-facing lower surface being entirely flat, and the pad including diamond particles;
(b) a reinforcement layer attached to the floor-facing surface of the pad, the reinforcement layer including an internal edge defining a hole therethough, and the reinforcement layer being flexible but stiffer than the pad;
(c) abrasive tools attached to a floor-facing surface of the reinforcement layer, the abrasive tools including diamond particles, and the abrasive tools being spaced apart from each other; and
(d) a central, porous and fibrous area of the floor-facing lower surface of the pad being exposed through the hole of the reinforcement layer such that a linear dimension X of the central area within the hole is greater than a linear dimension Y of one side of the reinforcement layer between the hole and a periphery thereof, and the upper surface of the pad at the central area being attachable to a free-standing powered floor polishing or grinding machine.

US Pat. No. 10,244,905

TOILET SEAT APPARATUS

TOTO LTD., Kitakyushu-Sh...

1. A toilet seat apparatus, comprising:a main part mounted at a rear upper part of a toilet;
a toilet seat provided rotatably with respect to the main part, a rear end part of the toilet seat being positioned at a rear part of the main part; and
a radio wave sensor being provided in an interior of the main part and using a radio wave to sense a human body, the rear end part of the toilet seat being positioned rearward of the radio wave sensor,
in a state in which the toilet seat is lowered, the toilet seat covering the radio wave sensor in a vertical direction, and the radio wave passing through the toilet seat and being radiated frontward of the radio wave sensor.

US Pat. No. 10,244,904

CONTROLLER FOR RAISING AND LOWERING A TOILET SEAT AND COVER

SHENZHEN MEGMEET ELECTRIC...

1. A control system applied to a toilet, the toilet comprising:a toilet seat and a seat cover;
the control system comprising a toilet seat actuation device which comprises a toilet seat motor which drives said toilet seat to pivotally move,
a seat cover actuation device which comprises a seat cover motor which drives said seat cover to pivotally move, and
a control circuit, which comprises a user detector configured to detect whether a user is present in a detecting range of the user detector, and a micro-controller, wherein said toilet seat motor and said seat cover motor are configured to be actuated by the micro-controller of said control circuit in a male operation mode, a female operation mode or a closed mode, wherein said toilet seat motor and said seat cover motor are configured to be actuated in said male operation mode by said micro-controller to lift up said toilet seat and said seat cover, wherein said seat cover motor is further configured to be actuated in said female operation mode by said micro-controller to lift up said seat cover, wherein said toilet seat motor and said seat cover motor are further configured to be actuated in said closed mode by said micro-controller to overlap said seat cover with said toilet seat for closing the toilet, wherein said control circuit is configured to preset, for each of said toilet seat and said seat cover, angular velocities for multiple angle ranges during lifting or dropping of said toilet seat and said seat cover, wherein the angular velocity of said toilet seat motor corresponding to each angle range of said toilet seat is constant, and the angular velocity of said seat cover motor corresponding to each angle range of said seat cover is constant, wherein said angular velocities of said toilet seat motor corresponding to different angle ranges of said toilet seat are different, and said angular velocities of said seat cover motor corresponding to different angles of said seat cover are different, wherein said toilet seat motor is further configured to be actuated such that an initial angular velocity of the toilet seat has a highest value when said toilet seat starts to lift up, and said seat cover motor is further configured to be actuated such that an initial angular velocity of the seat cover has a highest value when said seat cover starts to lift up, wherein said toilet seat motor is further configured to be actuated such that a final angular velocity of the toilet seat has a lowest value when lifting of said toilet seat is completed, and said seat cover motor is further configured to be actuated such that a final angular velocity of the seat cover has a lowest value when lifting of said seat cover is completed, wherein said toilet seat motor is further configured to be actuated such that an initial angular velocity of the toilet seat has a highest value when said toilet seat starts to drop down, and said seat cover motor is further configured to be actuated such that an initial angular velocity of the seat cover has a highest value when said seat cover starts to drop down, wherein said toilet seat motor is further configured to be actuated such that a final angular velocity of the toilet seat has a lowest value when dropping of said toilet seat is completed, and said seat cover motor is further configured to be actuated such that a final angular velocity of the seat cover has a lowest value when dropping of said seat cover is completed,
wherein said user detector comprises two microwave detectors located on top of the toilet and configured for detecting and analyzing a gesture of a user, and said toilet seat motor and said seat cover motor are each further configured to be automatically actuated in said male operation mode, said female operation mode or said closed mode, with said male operation mode corresponding to a situation that said microwave detectors detect the gesture of the user from left to right, said female operation mode corresponding to a situation that said microwave detectors detect the gesture of the user from right to left, and said closed mode corresponding to the situation that said microwave detectors detect no gesture of the user.

US Pat. No. 10,244,903

SCISSOR-STYLE TOILET BRUSH

The Libman Company, Arco...

1. A cleaning implement comprising:A cleaning attachment comprising a head with a non-circular cross section connected to a first side of a substantially planar support, and further comprising a cleaning pad secured to a second opposite side of the substantially planar support;
a first elongated member comprising a first handle, a first jaw, and a first shaft connecting the first handle and the first jaw; and
a second elongated member comprising a second handle, a second jaw, and a second shaft connecting the second handle and the second jaw,
wherein the second elongated member is configured to be affixed to the first elongated member at a pivot point such that the second elongated member may rotate about the pivot point, relative to the first elongated member, from a closed position, where the elongated members are essentially aligned with each other and where the first jaw and the second jaw are in contact with each other, to an open position, where the first jaw and the second jaw are not in contact with each other; and
wherein the first jaw and second jaw are configured to, when in the closed position, define a cavity shaped and sized to receive the head of the cleaning attachment and grasp the head of the cleaning attachment between them in a fixed position; and
wherein the head has one or more flat, outer surfaces, and wherein the first and second jaw collectively have one or more flat, inner surfaces defining at least part of the cavity, and wherein the inner and outer flat surfaces are adjacent to each other when the head is in the fixed position such that the flat surfaces prevent relative movement between the head and the jaws.

US Pat. No. 10,244,901

LEVITATION FLUID DISPENSER

OP-Hygiene IP GmbH, Nied...

13. A method of dispensing a fluid characterized by:sensing when a user is proximate to a levitator device, and
on sensing a user to be proximate to the levitator device, aerodynamically levitating in air a first drop of the fluid with an upwardly directed flow of air for a period of time at a height above the levitator device within a range of positions where the drop is accessible to be taken by a user's hand,
wherein the range of positions where the drop is accessible to be taken by the user's hand permits the drop to be grasped by the user's hand without the user's hand engaging anything other than the drop and the air within which the drop is levitated.

US Pat. No. 10,244,899

DISPOSABLE COVERS FOR HOT HANDLES

Spellbound Development Gr...

1. A flat sheet of material having a length, a width, and a thickness defined by a distance between a top surface and a bottom surface, the sheet comprising:each of at least first, second and third perforated tear lines disposed at least part way across the width of the sheet, wherein the first tear line is distanced from the second tear line by between 2 and 8 inches, inclusive, and the second tear line is distanced from the third tear line by between 2 and 8 inches, inclusive; and
wherein the length, width, and thickness selected such that tearing the sheet along the first, second, and third tear lines will produce at least a first section suitable to be rolled into a tube sized and dimensioned to fit around a handle of a cooking pot or pan, the thickness is at least 3 mm;
a first pattern of first connectors on at least a first side of the first section and
a second pattern of second connectors on at least a second side of the first section, wherein the first pattern interlocks with the second pattern.

US Pat. No. 10,244,897

SPATULA FOR CULINARY USE

TECHFOOD SNC DI IORI ANGE...

1. A food preparation method comprising the steps of:spreading a food product in liquid or creamy state on a cooling plane to form a layer of food product that changes to solid or pasty state through the effect of cooling; and
subsequently scraping said cooling plane using a spatula to detach at least one portion of said layer, wherein said spatula includes at least three parts that can be separated from each other and that are a spatula body made of plastics for foodstuffs, an insert made of metal removably fixed to a lower side of said spatula body, and an element made of metal removably fixed to an upper side of said spatula body, a scraping edge of said spatula being arranged on said insert, said insert including an upper surface that is bounded at the front by said scraping edge and behind by a rear edge, said rear edge being contiguous to an upper surface of said upper side of said spatula body, said element including a protrusion that emerges from said upper surface of said upper side of said spatula body at a distance from said rear edge, a portion of said spatula body being interposed between said element and said insert, said element being connected to said insert by means of at least one stem inserted into a hole obtained in said portion of said spatula body;wherein, during said scraping step, said protrusion meets said detached layer portion and deflects the portion to promote rolling up thereof.

US Pat. No. 10,244,896

FRYING MACHINE

FOODS TEC LTD., Tochigi ...

1. A frying machine comprising: a frying tank with an open top; a frying tank cover adapted to openably close the open top of the frying tank; and a frying basket put in and out of the frying tank, the frying machine being configured to heat oil contained in the frying tank, the frying basket containing frying ingredients is placed in the frying tank and the open top of the frying tank is closed with the frying tank cover, and fry the frying ingredients in the oil in the frying tank,the frying machine further comprising a first transfer mechanism adapted to move the frying basket in a vertical direction together with the frying tank cover, and
a second transfer mechanism adapted to horizontally move the frying basket and frying tank cover moved upward by the first transfer mechanism,
wherein when the frying basket and the frying tank cover are moved downward by the first transfer mechanism from above the frying tank, the top of the frying tank is closed with the frying tank cover with the frying basket placed in the frying tank, and
ingredients are carried into the frying basket and fried food is carried out of the frying basket by moving the frying basket and the frying tank cover to above the frying tank using the first transfer mechanism, moving the frying basket and the frying tank cover to a predetermined position in a horizontal direction using the second transfer mechanism, and causing the frying basket to descend to a predetermined ingredient input position or fried food output position using the first transfer mechanism.

US Pat. No. 10,244,895

AUTOMATED GRILL CLEANING SYSTEM

1. An automated grill cleaning system comprising:a cooking unit being configured to cook, said cooking unit having a housing and a grill being positioned in said housing, said housing having an outer wall, said outer wall of said housing having an exposed edge, said outer wall having a first lateral side, said grill being substantially aligned with said exposed edge; and
a cleaning unit being coupled to said cooking unit, said cleaning unit being positioned on said outer wall, said cleaning unit selectively engaging said grill, said cleaning unit urging itself to travel along said grill wherein said cleaning unit is configured to abrade debris from said grill, said cleaning unit comprises a mount being removably coupled to said housing, said mount comprising:
a first arm having a first end, a second end and an exterior surface extending between said first end and said second end, said exterior surface having a first side, a second side and a third side, said second side coextensively abutting said exposed edge of said outer wall, said first arm being positioned on said first lateral side of said outer wall having said third side facing said grill, said first arm being substantially hollow, said third side having a slot extending therethrough, said slot being substantially coextensive with said first arm.

US Pat. No. 10,244,894

RADIANT EMBERS COOKING SYSTEM

The Boltz Group, LLC, Ad...

1. A method for making a heat tent for a cooking grill comprising a burner, the method comprising:a. cutting a sheet metal according to a predetermined profile;
b. preparing a plurality of openings at predetermined intervals on the sheet metal;
c. bending the sheet to a predetermined angle along the central line to form a central ridge portion, a first sloped surface and a second sloped surface of the heat tent, wherein first sloped surface and a second sloped surface meet along the ridge;
e. fixing a bracket to the sloped surfaces, wherein the bracket is designed to create a space between the bracket and the sloped surface; and
f. removably placing a screen into the space between the bracket and the sloped surface to cover the openings, the screen for protecting the burner from grease or other food drippings.

US Pat. No. 10,244,882

COOKING VESSEL AND METHOD FOR MANUFACTURING THE SAME

KIMS HOLDING CO., LTD., ...

1. A method for manufacturing a non-stick cooking vessel, the method comprising the steps of: applying a photosensitive paint to a surface of a stainless steel plate to form a photosensitive paint layer; applying a film to a surface of the photosensitive paint layer, the film composed of black portions and transparent portions interspersed to create dotted patterns of the transparent portions surrounded by the black portions; irradiating the film with ultraviolet rays to only cure the photosensitive paint disposed underneath the dotted patterns of the transparent portions; removing the film, uncured portions of the photosensitive paint layer disposed underneath the black portions of the film, and a portion of the stainless steel plate disposed underneath the uncured portions of the photosensitive paint layer; followed by removing any remaining cured photosensitive paint layer to form a plurality of recessed portions in the stainless steel plate at locations underneath where the black portions of the film were prior to being removed, and to form raised portions in the dotted patterns in the stainless steel plate at locations underneath where the dotted patterns of the transparent portions of the film were prior to being removed, and thus forming a plurality of hexagonal structures on the stainless steel plate defined by a plurality of lines of dots, the dots having a diameter of 0.5 mm and comprising the raised portions; and forming a coating layer having a non-stick function only on the recessed portions of the stainless steel plate, thereby providing the non-stick cooking vessel, wherein the recessed portions have a depth of from 0.06-0.08 mm.

US Pat. No. 10,244,875

ADJUSTABLE MEDIA FRAME

Sean Lydon, Methuen, MA ...

1. A media frame comprising:an adjustable upper rail;
wherein the adjustable upper rail includes a first upper rail member and a second upper rail member;
wherein the first upper rail member slides in or over the second upper rail member to adjust the upper rail;
a center media fastener that is removable and repositionable along the adjustable upper rail;
a hanging pendant member; and
wherein the first upper rail member and the second upper rail member each contain at least one hanging connection point connecting the hanging pendant member to the adjustable upper rail of the media frame.

US Pat. No. 10,244,869

STADIUM CHAIR

Stadium Holding, Inc., S...

1. A stadium chair, comprising:a seat frame; having;
a first tab; and
a second tab;
a backrest frame pivotally coupled to the seat frame between the first tab and the second tab for rotation about an axis, the backrest frame being capable of forward rotation about the axis toward the seat frame and rearward rotation about the axis away from the seat frame; and
a biasing element coupled to at least one of the seat frame and backrest frame for forward biasing the backrest frame toward a neutral position relative to the seat frame, the biasing element allowing for limited rearward rotation of the backrest frame from the neutral position and allowing for forward rotation of the backrest frame from the neutral position;
wherein the biasing element contacts the backrest frame; and
wherein the biasing element is located between the first tab and the second tab.

US Pat. No. 10,244,850

AUTOMATIC OPENING FOR A COMPARTMENT IN A PACK

The North Face Apparel Co...

1. A wearable pack having at least one shoulder strap, comprising:a front surface and an opposing back surface, opposing side surfaces, and opposing top and bottom surfaces, the surfaces being arranged to define a compartment of a backpack;
the front surface having upper and lower portions, the upper portion comprising a hingeable section hingeably coupled to the lower portion, the hingeable section having a first condition providing an opening to the compartment in the pack and a second condition closing the opening to the compartment, wherein the front portion is movable relative to the back portion by the front portion's hinging along a joint that is defined by (1) a lower end of the hingeable section and (2) the top end of the lower portion of the front surface;
a closure system for locking the hingeable section in the closed condition; and the hingeable section being coupled to a spring system that is unloaded when the
hingeable section is in the first condition and relatively loaded when in the second condition so that the compartment automatically opens when the closure system is released.

US Pat. No. 10,244,845

CONTAINER AND APPLICATOR FOR POWDERS AND LIQUIDS

Presto Packaging Solution...

1. A combined container cap and applicator, for the transfer of a powdered or liquid material from the container and for application of the material to a substrate, comprising an applicator sponge mounted to the interior of the cap via a rotating holder, and a wiper mounted to the container, wherein(a) the cap is a threaded cap, the threads being a first set of threads which are complimentary to threads on the container;
(b) the holder moves helically with respect to the cap; and
(c) the wiper reversibly holds the sponge by friction in a fixed position relative to the container when the container is closed by the cap; such that
(d) when the cap is unscrewed from the container, the wiper holds the sponge and the holder fixed relative to the container, causing the holder and sponge to move helically outward relative to the cap, and
(e) when the cap is screwed onto the container, the wiper holds the sponge and the holder fixed relative to the container, causing the holder and sponge to move helically inward relative to the cap;whereby the helically outward and helically inward motions, respectively, result in a telescopic motion of the holder outward and inward with respect to the cap.

US Pat. No. 10,244,844

COSMETIC CONTAINER HAVING APPLICATION MEMBER DETACHABLY ATTACHED TO SIDE OF BUTTON MEMBER

PUM-TECH KOREA CO., LTD.,...

1. A cosmetic container having an application member detachably attached to a side of a button member, the cosmetic container comprising:a container body (10) having a storage space (13);
a pump (20) for discharging contents of the container body (10);
a cap (30) for fixing the pump (20) to the container body (10);
the button member (40) coupled to an upper part of the pump (20) and formed to protrude upward of the cap (30); and
the application member (50) detachably attached to the side of the button member (40),
wherein the button member (40) comprises:
a first outlet (41) through which discharging contents from the pump (20) passes; and
a push protrusion (42) on an upper surface of the button member (40), and
wherein the application member (50) comprises a second outlet (55) through which discharging contents from the first outlet (41) passes.

US Pat. No. 10,244,841

STRUCTURE OF HAND-CARRYING PORTION OF BAG AND METHOD FOR ATTACHING THE SAME

HAYASHIGO CO., LTD., Osa...

1. A structure of a hand-carrying portion attached to a bag main body, comprising:an outer side hand-carrying member; and
an inner side hand-carrying member partially overlapped with an inner side of the outer side hand-carrying member,
wherein the inner side hand-carrying member is a long, band-shaped body, and the outer side hand-carrying member is a long, band-shaped body having a wider width than the inner side hand-carrying member,
the outer side hand-carrying member and the inner side hand-carrying member have different lengths, the outer side hand-carrying member being longer than the inner side hand-carrying member,
the inner side hand-carrying member is joined with the outer side hand-carrying member on an outer surface covered by the outer side hand-carrying member in a joining region including a hand-carrying region,
the inner side hand-carrying member has a non-joining region, which is not sewn to the outer side hand-carrying member, the non-joining region being a flat, band-shaped portion of the long, band-shaped body that makes up the inner side hand-carrying member,
the outer side hand-carrying member is joined to an outer side of the inner side hand-carrying member in the joining region including the hand-carrying region, and the outer side hand-carrying member is curved to a U-shape with the inner side hand-carrying member in the hand-carrying region in a front view,
the outer side hand-carrying member is folded around the inner side hand-carrying member to form an overlapped region centered between one end of the inner side hand-carrying member and another end of the inner side hand-carrying member, and centered between one end of the outer side hand-carrying member and another end of the outer side hand-carrying member,
the outer side hand-carrying member and the inner side hand-carrying member are sewn together in a vicinity of a longitudinal end edge of the outer side hand-carrying member and a vicinity of a longitudinal end edge of the inner side hand-carrying member to form a sewing portion in the overlapped region so as to form the joining region including the hand-carrying region,
the one end of the inner side hand-carrying member is attached to the outer surface of the main bag body at one attachment portion, and the another end of the inner side hand-carrying member is attached to the outer surface of the main bag body at another attachment portion,
the sewing portion extends to a vicinity of the one end of the inner side hand-carrying member and a vicinity of the another end of the inner side hand-carrying member, such that a space exists between the sewing portion and the one attachment portion, and a space exists between the sewing portion and the another attachment portion,
the outer side hand-carrying member includes a flat-shaped extended region that extends in a top-to-bottom direction of the bag main body from the joining region including the hand-carrying region overlapped with the inner side hand-carrying member,
in the extended region of the outer side hand-carrying member, the outer side hand-carrying member has a non-joining region where the outer side hand-carrying member is not sewn to the inner side hand-carrying member,
the non-joining region includes a sandwiching portion for sandwiching an article in a space between the inner side of the outer side hand-carrying member and the outer surface of the bag main body,
the outer side hand-carrying member is attached, at one end, to the outer side of the bag main body at a first lower attachment portion in the extended region of the outer side hand-carrying member, and, at another end, to the outer side of the bag main body at a second lower attachment portion, the first and second lower attachment portions spaced apart from each other, such that an interval exists between the one attachment portion of the inner side hand-carrying member and the first lower attachment portion of the outer side hand-carrying member and between the another attachment portion of the inner side hand-carrying member and the second lower attachment portion, and
the lower attachment portion includes a flat portion of the outer side hand-carrying member brought into contact with, and sewn to, the outer surface of the bag main body.

US Pat. No. 10,244,835

UMBRELLAS WITH INFLATABLE PORTIONS

The Handwerker Umbrella C...

1. An umbrella comprising:a support assembly having a first end and a second end, the support assembly comprising an air pump; and
a canopy assembly comprising:
a hub fixed to the second end of the support assembly;
a plurality of support ribs attached to the hub;
a sheet coupled to the hub;
a toroidal air bladder coupled to the air pump, the air bladder disposed about a handle between the hub and the first end of the support assembly; and
a plurality of support straps, each support strap extending from an upper surface of the hub to a lower surface of the toroidal air bladder when the umbrella is positioned for use.

US Pat. No. 10,244,832

DOUBLE LOCK MECHANISM

Patdiam Jewellery Limited...

1. A double lock mechanism comprising:a post section comprising a locking post and a plurality of post slots recessed into the locking post; and
a locking section configured to engage the post section, the locking section comprising:
an insertion cavity configured to receive the locking post;
a plurality of locking bars, each locking bar comprising an outwardly facing side and an inwardly facing side,
wherein each of the outwardly facing sides comprises a grip surface, and
wherein each of the inwardly facing sides comprises a first end having a locking tip configured to engage one of the plurality of post slots, a second end having a spring tip, and an attachment point between the first end and second end at which each of the locking bars are pivotally coupled to the locking section, wherein the attachment point of each of the inwardly facing sides share a common pivoting axis comprising a pin to which the locking bars are attached to each other and about which the locking bars pivot,
wherein a distance from each of the locking tips to the attachment points on the respective locking bars are of different lengths such that the locking tips are offset along the locking post from each other, and
a spring having two ends, each end attached to each of the spring tips, the spring configured to spread the spring tips away from each other and bias the locking bars in an engaged orientation relative to the post slots, such that the locking tips engage the post slots;
wherein the plurality of locking bars are configured to disengage the post section when an external pressing force is applied to the grip surfaces, causing the spring to compress, causing a first rotational movement of the locking bars around the attachment point, causing a second rotational movement of the locking tips in the opposite direction of the first rotational movement, and causing each of the locking tips to disengage the one of the plurality of post slots.

US Pat. No. 10,244,828

WIDE TOP NARROW BOTTOM TYPE DOUBLE-LAYER ZIPPER FOR LUGGAGE AND ZIPPER SLIDER FOR SAME

GENMORE ZIPPER CORPORATIO...

1. A wide top narrow bottom type double-layer zipper, comprising a top and bottom zipper set, and a zipper slider coupled to said top and bottom zipper set and movable in one of two opposite directions to close or open said top and bottom zipper set, said top and bottom zipper set comprising left and right zipper tapes, top and bottom interlocking coils stitched to opposing top and bottom surfaces of said left and right zipper tapes to form two left series of interlocking teeth and two right series of interlocking teeth, said top and bottom interlocking coils each comprising a filler cord and a polyester coil spirally extended around said filler cord, wherein:the combined width of the interlocked said bottom interlocking coils is smaller than the combined width of the interlocked said top interlocking coils; said top interlocking coils and said bottom interlocking coils have the same spiral pitch; the top and bottom layers of the wide top narrow bottom type double-layer zipper are vertically aligned and sewed;
said zipper slider comprises a top cover panel, an opposing bottom cover panel, opposing left and right guard flanges respectively and perpendicularly located at respective opposite lateral sides of said top cover panel and said bottom cover panel, an upright base center connected between said top cover panel and said bottom cover panel on the middle, a top chamber defined by said top cover panel for accommodating said top interlocking coils and a bottom chamber defined by said bottom cover panel for accommodating said bottom interlocking coils, the width of said bottom cover panel being smaller than the width of said top cover panel, said bottom chamber being relatively narrower and shorter than said top chamber.

US Pat. No. 10,244,812

APPARATUS FOR DISPERSING IMPACT FORCES

Newtonoid Technologies, L...

1. A system for mitigating an impact force, the system comprising a helmet having a face mask attached thereto, the face mask comprising a face mask bar extending from a first side of the helmet to a second side of the helmet defining a length, the face mask bar comprising first and second bar portions each extending along the entirety of the length;wherein:
the first portion and the second portion are separated by a gap and held together via a biasing member; and
a force received by the first portion is at least partially transferred to the second portion via the biasing member;
a fraction of the transferred force is returned to the first portion, the fraction being less than the force received.

US Pat. No. 10,244,809

HELMET FOR ATTENUATING IMPACT EVENT

Linares Medical Devices, ...

1. A helmet, comprising:a rigid shell adapted to be supported over a wearer's head;
at least one deflecting and force absorbing portion extending from and along a lower rim edge of said rigid shell, each of said deflecting and force absorbing portion having, in cross section, a cupped interior, coiled springs extending from said cupped interior and securing to said rigid shell so that that an extending bottom rim edge of said rigid shell is positioned within the cupped interior and each of said deflecting and force absorbing portion projecting both interiorly and exteriorly of said rigid shell;
an array of interior head supporting and force absorbing portions secured to interior locations of said rigid shell and including an upper most collapsible portion adapted to support a top of the user's head, a cushioning ring array extending around an intermediate perimeter of said rigid shell and adapted to support a crown of the wearer's head, and a semi-circular support adapted to support a base of the wearer's head along a lower rear of said rigid shell and to provide a rear neck support; and
upon the wearer experiencing a head impact force exerted on said rigid shell from any direction, bending of a neck of the wearer adapted to being limited by contact between each of said deflecting and force absorbing portion projecting exteriorly and any of a shoulder or upper back of the wearer, concurrent with said array of interior head supporting and force absorbing portions each providing individual and varied controlled collapsing as determined by an angle and direction of the head impact force.

US Pat. No. 10,244,807

AIRWAY OPENING DEVICE FOR HELMETS AND A HELMET COMPRISING THE SAME

INOVYTEC MEDICAL SOLUTION...

1. A helmet mounted safety device for ensuring an open airway, comprising right and left mandible engaging sections,wherein each of said mandible engaging sections comprises:
i) an adjustable and angled airway opening member having a first element configured to contact a bottom of a corresponding mandible angle of a helmet wearer, and a second element which is angularly spaced from said first element and which is configured to contact the corresponding mandible angle proximate to a junction with a ramus and to assure opening of the airway of the helmet wearer;
ii) an element configured with an anteroposteriorly extending groove;
iii) means connected to said airway opening member and passing through said groove, to urge anteroposterior displacement of said airway opening member; and
iv) a connecting element for connection to an area of an interior face of a corresponding inferior region side portion of a helmet that is sufficiently spaced from a corresponding mandible of the helmet wearer to facilitate engagement between said airway opening member and the corresponding mandible angle only following selective anterior displacement of said airway opening member that applies a force to the corresponding mandible angle to cause jaw opening and ensure an open airway.

US Pat. No. 10,244,804

GARMENT VENT

BERGHAUS LIMITED, London...

1. A garment comprising:a vent path extending from an outside of the garment to an interior of the garment,
an upper outer panel having a lower end portion,
a lower inner panel having an upper end portion,
the lower end portion of the upper outer panel overlapping the upper end portion of the lower inner panel so as to form a vent opening between the lower end portion and the upper end portion,
a gutter formed as a downward fold from one of the panels, the gutter extending from the fold into the vent opening,
the vent opening being opened above the upper end portion of the lower inner panel,
an access opening from the vent opening into the interior of the garment, and
wherein the vent path is unobstructed from the outside of the garment, through the vent opening, around the gutter and through the entire access opening into the interior of the garment, wherein the upper outer panel and the lower inner panel are operatively engaged with each other at opposite ends of the access opening, such that an air flow with a continuous width equal to an entire width of the access opening between the opposite ends of the access opening can pass through the access opening into the interior of the garment.

US Pat. No. 10,244,779

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

Senomyx, Inc., San Diego...

1. A liquid composition comprising a sweet enhancer having structural formula (Ia) or (I?a), or a salt or solvate thereof:
and
a phenol-based antioxidant, or a salt or solvate thereof, as a photostabilizer,
wherein:
A is —OR1, —NR1C(O)R2, —NHOR1, —NR1R2, —NR1CO2R2, —NR1C(O)NR2R3, —NR1C(S)NR2R3 or —NR1C(?NH)NR2R3;
B is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl,
C is —OR7, —S(O)bR7, —SO3R7, —C(O)NR7R8, —CO2R7, —NR7CO2R8, —NR7C(O)NR8R9, —NR7C(?NH)NR8R9, —SO2NR7R8, —NR7SO2R8, —NR7SO2NR8R9, —B(OR7)(OR8), —P(O)(OR7)(OR8), —P(O)(R7)(OR8), or heteroaryl;
b are independently 0, 1 or 2;
R1, R2, R3, R7, R8, and R9 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; or alternatively, R1 and R2, R2 and R3, R7 and R8, or R8 and R9, together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring;
R21 is hydrogen, alkyl, substituted alkyl, halo, —CN, —OR25;
R22 is hydrogen, alkyl, substituted alkyl, halo, —CN, —OR27;
R23 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —CN, —OR29, —S(O)fR29, —OC(O)R29, —NR29R30, —C(O)NR29R30, C(O)R29, —CO2R29, —SO2NR29R30, —NR29SO2R30, —B(OR29)(OR30), —P(O)(OR29)(OR30) or —P(O)(R29)(OR30);
R24 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —CN, —OR31, —S(O)gR31, —OC(O)R31, —NR31R32, —C(O)NR31R32, —C(O)R31, —CO2R31, —SO2NR31R32, —NR31SO2R32, —B(OR31)(OR32), —P(O)(OR31)(OR32) or —P(O)(R31)(OR32); or alternatively R23 and R24, taken together with the atom to which they are attached, form a cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, or substituted cycloheteroalkyl ring;
f and g are independently 0, 1 or 2; and
R25, R27, R29, R30, R31, and R32 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; or alternatively R25 and R27, R27 and R29, R29 and R30, R29 and R31, or R31 and R32, together with the atoms to which they are attached, form a cycloheteroalkyl or substituted cycloheteroalkyl ring.

US Pat. No. 10,244,767

FORMATIVE STRUCTURAL CAKE SYSTEM

Cake Effects LLC, Lake W...

1. A mold system comprising:a first mold portion comprising a dimensional feature formed in a wall of the first mold portion, the first mold portion having a periphery and at least one aperture through the wall;
a second mold portion having a periphery, the second mold portion being alignable to the first mold portion so that the periphery of the first mold portion aligns with the periphery of the second mold portion and an interior space is formed between the first mold portion and the second mold portion;
a fill opening in an upper portion of the mold system and connected to the interior space;
an opening in a bottom portion of the mold system and connected to the interior space;
a base plate connected to the bottom portion for sealably connecting the first mold portion and the second mold portion to the base plate; and
an inner portion of an edible composition, the edible composition having an inner portion having a dimensional mass and an outer portion, the inner portion positioned on the base plate and within the interior space so that a cavity is formed between the inner portion and at least a portion of the wall of the mold system forming the interior space, wherein the cavity extends to the base plate.

US Pat. No. 10,244,741

LURE

Hard and Soft Fishing, In...

9. A lure comprising:a head with a bore formed therein, wherein the bore extends from a first side of the head to a second side of the head;
a hook with a first end embedded in the head;
a sealed tube located within the bore and affixed to the head, the sealed tube made from a material that permits at least some light through the material; and
at least two noise making elements located within the sealed tube;
wherein when at least one of the at least two noise making elements contacts a first end of the sealed tube, the at least one of the at least two noise making elements make a noise;
wherein when at least one of the at least two noise making elements is positioned near the first end of the sealed tube, the at least one of the at least two noise making elements is observable through the first end; and
wherein when at least one of the at least two noise making elements is positioned near a second end of the sealed tube, the at least one of the at least two noise making elements is observable through the second end.

US Pat. No. 10,244,738

TEMPERATURE CONTROLLING AQUARIUM CLEANING DEVICE

Bernard Ruiz, Ridgewood,...

1. A temperature controlling aquarium cleaning device comprising:(1) a diverter body comprising:
(a) a diverter first end configured to removably couple to the water source,
(b) a diverter second end configured to allow a flow of dirty water through said water diverter member into a sink, and
(c) diverter connector configured to removably couple with a first end of a hose;
(2) a siphoning member comprising:
(a) a siphoning body with
(i) a first end configured to removably couple with a second end of the hose, and
(ii) a second end opposite the first end of the siphoning member,
wherein the siphoning member is configured to allow the flow of water therethrough; and
(3) an end cap is configured to be moveable between a filling position and a removing position at the water diverter second end, the filling position blocking flow of fresh water through the water diverter second end into the sink, thereby allowing the flow of fresh water into the aquarium, and the removing position allowing dirty water to flow from the aquarium through the water diverter second end into the sink;
wherein dirty water is removed from the aquarium by siphoning the dirty water through said siphoning second end, the dirty water then passes through the siphoning member, the hose, the diverter member, and exits said water diverter member second end into the sink, with the end cap in the removing position;
wherein fresh water is added to the aquarium by turning on the water source, as a result, the fresh water passes through said diverter body, the hose, and through said siphoning member into the aquarium, with the end cap in the filling position;
and
(4) a temperature gauge comprising:
(1) a sensor attached to a back surface of the gauge, the sensor configured to contact and sense a temperature of the fresh water entering said diverter body;
(2) a display member configured to display the measured temperature of the fresh water; and
(3) a power source configured to provide energy to said display member;
wherein said temperature gauge is fixedly attached to said diverter body.

US Pat. No. 10,244,730

DIGESTATE COMPOSITION COMPRISING LIGNOCELLULOSIC FIBROUS MATERIALS AND METHOD

CCD Holdings LLC, Hollan...

1. Digestate composition, comprising:at least one solvent;
a lignocellulosic fiber processed by ruminant digestion and anaerobic digestion; and
wherein a density fiber of the digestate composition ranges from between approximately 0.400 grams per cubic centimeter to approximately 1.40 grams per cubic centimeter.

US Pat. No. 10,244,689

SOILLESS PLANT CULTIVATING CONTAINER

E-SMARTS GLOBAL LICENSING...

1. A soilless plant cultivating container comprising:an elongate body of wave shaped form and having a flow channel defined therethrough;
a receptacle defined in a sidewall of the body in fluid communication with the flow channel to receive and support a plant therein, and
the elongate body further including an air passage arranged separate from the flow channel and extending longitudinally therealong, the air passage being in fluid communication with the receptacle for introducing temperature and oxygen regulated air to the receptacle.

US Pat. No. 10,244,687

LED GROW LIGHT SYSTEM

Spectrum King LLC, Canog...

1. An LED grow light system, comprising:an LED coupled to a circuit board;
a phosphor layer generally positioned at least partially over the LED coupled to the circuit board;
a filter positioned in light receiving relation relative to the LED coupled to the circuit board and in light reflective relation relative to the phosphor layer, the filter comprising a material at least partially reflective of at least a first light output wavelength emitted from the LED for redirection back into the phosphor layer where the reflected first light output wavelength converts to a second light output wavelength for recycled emission out from the LED grow light system as a composite light output component comprising a mixture of the first light output wavelength and the second light output wavelength; and
an adhesive selectively securing the filter to the phosphor layer, wherein the filter comprises a filter substrate having a filter coating on an external surface area of the LED grow light system.

US Pat. No. 10,244,682

CONVEYOR BELT AND AGRICULTURAL HARVESTER WITH A CONVEYOR BELT

Maschinenfabrik Krone Bet...

1. A conveyor belt comprising:conveyor belt segments comprising an elastomeric material layer and a reinforcement layer of steel ropes disposed in the elastomeric material layer and arranged so as to be oriented in a longitudinal direction of the conveyor belt segments, wherein the conveyor belt segments each have a first segment end provided with a first transverse lock bar and a second segment end provided with a second transverse lock bar, wherein ends of the steel ropes are locked frictionally or with form fit in the first and second transverse lock bars, respectively;
detachable closure members coupling the first and second transverse lock bars of adjacently positioned ones of the conveyor belt segments to each other in a rigid correlation relative to each other;
wherein the conveyor belt segments are arranged to form a first belt and a second belt extending parallel to each other;
rod elements oriented at least approximately transversely to a running direction of the conveyor belt, wherein the rod elements each comprise a first end disposed at the first belt and a second end disposed at the second belt, respectively;
wherein the detachable closure members comprise fastening means fastening the first end to the first belt or the second end to the second belt, respectively.

US Pat. No. 10,244,672

METERING SYSTEM FOR AN AGRICULTURAL MACHINE

Horsch Maschinen GmbH, S...

1. A metering system for a row unit of an agricultural machine for an individual dispensing of grains, comprisingat least two metering devices, whereby the at least two metering devices include at least one chamber for carrying a quantity of the grains that are to be dispensed,
at least two metering elements that establish a border to the at least one chamber, whereby the at least two metering elements are rotatably mounted within the housing of the at least two metering devices and each of the metering elements includes openings, which are arranged along a curved path at regular intervals for picking up grains, and
at least one grain dispensing area, which is defined by the at least one chamber and by the at least two metering elements, wherein the at least one grain dispensing area is adjacent a seed inlet element for a seed metering pipe through which the separated grains are dispensed into a seed furrow in the soil, and
whereby a pressure application device, in communication with the at least one chamber or to a pipe of the air supply of the at least one chamber or in communication with both the at least one chamber and to the pipe of the air supply of the last least one chamber, operably produces a stream of air in the grain dispensing area having a pressure that is sufficiently greater than ambient pressure such that the grains released from a selected metering element are accelerated by the stream of air into the seed metering pipe.
US Pat. No. 10,246,705

LINKING SEQUENCE READS USING PAIRED CODE TAGS

Ilumina, Inc., San Diego...

1. An artificial transposon, comprising:a first transposase recognition site,
a second transposase recognition site,
a barcode disposed therebetween, wherein the barcode comprises a double-stranded nucleic acid sequence comprising
a first strand barcode and
a second strand barcode, wherein the first strand barcode and the second strand barcode comprise non-complementary sequences; and
a fragmentation site disposed within the first strand barcode and the second strand barcode.
US Pat. No. 10,246,706

METHODS AND COMPOSITIONS FOR PREVENTING CONCATEMERIZATION DURING TEMPLATE-SWITCHING

New England Biolabs, Inc....

10. A composition comprising:(a) a reverse transcriptase;
(b) an oligonucleotide for template switching, wherein the oligonucleotide comprises a 3? end having at least one nucleotide that can hybridize to one or more non-templated nucleotides added to a templated cDNA strand by the reverse transcriptase; and
(c) polyethylene glycol having an average molecular weight in the range of about 3350 to about 8000.
US Pat. No. 10,247,730

METHOD FOR DETERMINING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) RELATED BIOMARKERS, A METHOD TO MONITOR THE DEVELOPMENT AND TREATMENT OF ARDS IN A PATIENT

FARON PHARMACEUTICALS OY,...

1. A method for the treatment of a patient suffering from acute respiratory distress syndrome (ARDS), the method comprising:obtaining a serum sample from the patient at a first point in time before administering interferon beta;
treating the patient with interferon beta during a treatment period;obtaining a serum sample from the patient at a later point in time during the treatment period; anddetermining a change in the levels and/or activities of three biomarkers and optionally an additional one to five biomarkers in the serum sample obtained at the first point in time compared to the levels and/or activities of the biomarkers in the serum sample obtained at the later point in time; andwherein the treatment of the patient with interferon beta is continued when the biomarkers each discontinue showing a favorable change, or start to show an unfavorable change;wherein the three biomarkers are CD73, IL-6 and human eotaxin-1 (CCL11) and whereinthe one to five additional biomarkers are selected from the group consisting of interleukin-1 receptor antagonist (IL-1 ra), interleukin-8 (IL-8), interleukin-15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein (MIP-1a).
US Pat. No. 10,246,707

METHOD FOR EFFICIENT EXON (44) SKIPPING IN DUCHENNE MUSCULAR DYSTROPHY AND ASSOCIATED MEANS

Biomarin Technologies B.V...

1. A single stranded antisense oligonucleotide 16 to 25 nucleotides in length that comprises a base sequence of the sequence selected from the group consisting of SEQ ID NO: 5 to SEQ ID NO: 16, SEQ ID NO: 20 to SEQ ID NO: 28, SEQ ID NO: 30 to SEQ ID NO: 34, SEQ ID NO: 41, and SEQ ID NO: 46, wherein the antisense oligonucleotide induces skipping of exon 44 of human dystrophin pre-mRNA, and comprises a modification.
US Pat. No. 10,246,712

GENETIC OR PHARMACOLOGICAL REDUCTION OF PERK ENHANCES CORTICAL- AND HIPPOCAMPUS-DEPENDENT COGNITIVE FUNCTION

Carmel-Haifa University E...

1. A method for improving a cognitive function in a subject having age-related cognitive dysfunction, said method comprising administering to said subject an active agent reducing PKR-like endoplasmic reticulum kinase (PERK) activity.
US Pat. No. 10,247,738

DIAGNOSING AND TREATING ALZHEIMERS DISEASE

DIGNITY HEALTH, San Fran...

1. A method of diagnosing late onset Alzheimer's disease (LOAD) in an individual, comprising:obtaining a cerebrospinal fluid sample from the individual;
preparing the sample to be assayed by a serological test to determine the presence or absence of low PACAP expression levels;
diagnosing LOAD based on the presence of low PACAP protein levels relative to those levels found in a healthy subject; and
administering a composition comprising PACAP to the individual when the PACAP protein expression level in the individual's cerebrospinal fluid is below levels found in the healthy subject.
US Pat. No. 10,246,717

WHEAT WITH INCREASED RESISTANT STARCH LEVELS

ARCADIA BIOSCIENCES, INC....

1. A wheat plant of the species Triticum turgidum L. ssp durum comprising one or more homozygous severe mutations in both SBEIIa alleles of each SBEIIa gene of the A and B genomes, wherein said wheat plant produces grain that germinates, and wherein the grain from said wheat plant has an increased amylose level as compared to grain from a wild type wheat plant.
US Pat. No. 10,246,473

PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE

Dow Corning Corporation, ...

1. A process for purifying an acryloyloxysilane, the process comprising:subjecting a mixture comprising an acryloyloxysilane, a haloorganoalkoxysilane, and a non-polar solvent, wherein the non-polar solvent comprises a mixture of 0.5 to 15% (w/w) of a branched-chain alkane having from 5 to 20 carbon atoms and 85 to 99.5% (w/w) of a straight-chain alkane having from 5 to 14 carbon atoms, based on the weight of the branched-chain and straight-chain alkane in the non-polar solvent, and wherein the non-polar solvent comprises less than 5% (w/w), based on the weight of the non-polar solvent, of an aromatic compound, to a temperature and pressure sufficient to vaporize a portion of the non-polar solvent, the haloorganoalkoxysilane, or the non-polar solvent and the haloorganoalkoxysilane from the mixture to produce a purified mixture comprising the acryloyloxysilane.
US Pat. No. 10,246,729

PROCESS FOR THE RECOVERY OF BETAINE FROM MOLASSES

TIENSE SUIKERRAFFIINADERI...

1. A process for the recovery of betaine from a sugar beet molasses said method comprising the steps of:providing a starting material containing between 45 and 65 wt. % sucrose, between 3 and 8 wt. % betaine, between 6 and 10 wt. % amino acids, as well as fructose, glucose and inorganic salts, wherein the starting material comprises a sugar beet molasses by-product formed in a process for preparation of sucrose,
a conversion step, in which the sugar beet molasses starting material is first subjected to the action of a fructan-forming enzyme, having endo-inulinase activity and/or fructosyltransferase activity, whereby at least 80 wt % of the sucrose contained in the sugar beet molasses is converted to form a fructo-oligosaccharide- containing molasses (FOS-molasses); and
a separation step, in which the FOS-molasses from the conversion step is subjected to a chromatographic separation, thereby obtaining a betaine-containing fraction having a ratio of betaine to other dry-matter constituents of the FOS-molasses of at least 70:30, wherein:
prior to the separation step the FOS-molasses from the conversion step is heated to a temperature of between 80-90° C. and held at such temperature for between 5 and 30 minutes to deactivate the enzyme and reduce any bacteria that may be present in the FOS-molasses,
the separation step is accomplished by ion-exchange chromatography in a simulated moving bed chromatography system,
a cation exchange resin is used in the ion-exchange chromatographic separation step, and
prior to the separation step the molasses or the fructan-molasses is subjected to an ion-exchange step, whereby the concentration of those cations in the molasses or in the fructan-molasses that are different from the cation exchange resin, is reduced by at least 90%.
US Pat. No. 10,245,451

AMINOFUNCTIONAL ORGANOSILOXANES

Dow Silicones Corporation...

1. A method of treating a surface of a fiber, the method comprising applying an aqueous emulsion to the surface of the fiber, wherein the aqueous emulsion comprises:A) an aminofunctional silicone composition comprising an organopolysiloxane having an average formula:
(CH3)3SiO[(CH3)2SiO]x[(CH3)RNSiO]ySi(CH3)3
with less than 1 weight % of nitrogen in its formula,
where RN is an aminofunctional group, x is ?100, and y is ?1, with the proviso that the sum of x+y is from 250 to 350; and
B) a quaternary ammonium surfactant having a formula:
R1R2R3R4N+X?,
where R1 is a radical containing at least 10 carbon atoms, R2 is R1 or a hydrocarbyl containing 1 to 12 carbon atoms, R3 is R1, R2, or an alcohol group containing 2 to 10 carbon atoms, R4 is R1, R2, or R3, and X? is a halide, sulfate, sulfonate, methosulfate, or ethosulfate;
wherein the viscosity of A) the aminofunctional silicone composition ranges from 1000 to 2500 cP at 25° C. as measured by a Brookfield RV DV viscometer equipped with Pro CP 52 spindle at 20 RPM;
wherein A) the aminofunctional silicone composition contains less than 0.1 weight % of octamethylcyclotetrasiloxanes (D4) and less than 0.1 weight % decamethylcyclopentasiloxanes (D5) cyclic siloxanes; and
wherein B) the quaternary ammonium surfactant is present in the aqueous emulsion in an amount of at least 0.5 weight %.
US Pat. No. 10,246,476

METHOD FOR PREPARING D-PSICOSE CRYSTAL

CJ CHEILJEDANG CORPORATIO...

1. A method for producing D-psicose crystals having a grain size of MA200 ?m or larger, comprising:removing impurities from a D-psicose solution to obtain a purified D-psicose solution;
concentrating the purified D-psicose solution to provide a concentrated D-psicose solution having a concentration of 80 Brix (%) to 85 Brix (%);
performing rapid cooling of the concentrated D-psicose solution to 30° C. to 40° C. in a heat exchanger to provide a copied D-psicose solution having a temperature between 3° C. and 4° C., wherein the rapid cooling is performed at a cooling rate of 5° C. to 20° C. per hour;
placing the cooled D-psicose solution at a temperature between 30° C. and 40° C. to a crystallizer and adding D-psicose seed crystals to the crystallizer;
performing seeded crystallization of D-psicose in the crystallizer while controlling temperature to stay between 30° C. and 40° C., which provides a D-psicose massecuite having a temperature between 30° C. and 40° C.; and
performing full-scale crystallization of D-psicose using the D-psicose massecuite while controlling temperature to stay between 30° C. and 40° C., which provides D-psicose crystals having a grain size of MA200 ?m or larger.
US Pat. No. 10,246,732

STABILIZED TEST STRIP FOR THE DETECTION OF HYDROGEN PEROXIDE

PRECISION LABORATORIES, I...

1. A colorimetric dry-reagent test strip for direct detection of the presence of hydrogen peroxide in strongly acidic solutions without the necessity of a neutralization step, consisting essentially of a chromogen responsive to hydrogen peroxide, an enzyme peroxidase catalyst and at least one complexing agent at a concentration that effectively protects an active site of the catalyst for an amount of time sufficient to allow for the catalytic oxidation of the chromogen when contacted with hydrogen peroxide-containing solutions having a pH in the range of 0 to 1, wherein the components are in a dry form on a carrier.
US Pat. No. 10,246,733

ASSAY AND METHOD FOR QUANTITATING CARBONIC ANHYDRASE ACTIVITY AND ASSESSING RED BLOOD HEMOLYSIS

CASE WESTERN UNIVERSITY, ...

1. A method of measuring the amount or activity of carbonic anhydrase enzyme, in a bodily sample, the method comprising:mixing a bodily sample including RBC lysate with a first physiological CO2/HCO3? solution, the first physiological CO2/HCO3? solution having a pH of about 7;
mixing the first physiological CO2/HCO3? solution, which includes the bodily sample, with a second CO2/HCO3? solution, which includes NaHCO3, having a basic dissimilar pH; and
measuring the rate at which the pH of the newly mixed solution equilibrates under the influence of the enzyme to determine carbonic anhydrase activity.
US Pat. No. 10,245,456

PROCESS FOR DECONTAMINATION AND DETOXIFICATION WITH ZIRCONIUM HYDROXIDE-BASED SLURRY

The United States of Amer...

1. A process for decontaminating surfaces contaminated with at least one toxic agent, comprising applying onto said contaminated surfaces a decontamination composition comprising an aqueous or non-aqueous carrier liquid and at least two types of Zr(OH)4 including a first type Zr(OH)4 and a second type Zr(OH)4, wherein said first type Zr(OH)4 has an average particle size of up to 100 nm and said second type Zr(OH)4 has an average particle size of at least 10 ?m, and wherein said decontamination composition has a weight ratio of said first type Zr(OH)4 to said second type Zr(OH)4 in the range of about 5:1 to 2:1.
US Pat. No. 10,246,488

USE OF INHIBITORY PEPTIDES FOR THE TREATMENT OF INFLAMMATORY DISEASES

Yeda Research and Develop...

1. An isolated peptide comprising an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1(PERYQNLSPV), the isolated peptide comprising a nuclear targeting activity, the peptide being no longer than 20 amino acids.
US Pat. No. 10,246,747

METHODS OF USING MIRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD)

DiamiR, LLC, Princeton, ...

1. A method for identifying a compound useful for slowing down the progression of or treating pre-MCI or MCI, which method comprises:a. measuring the level of at least one synapse or neurite miRNA in one or more bodily fluid samples collected from a subject having pre-MCI or MCI, wherein the synapse or neurite miRNA is selected from the group consisting of miR-7, miR-125b, miR-128, miR-132, miR-874, miR-134, miR-323-3p, and miR-382, wherein said bodily fluid sample(s) is collected prior to test compound administration and wherein the bodily fluid is selected from the group consisting of blood plasma, serum, urine, and saliva;
b. measuring the level of a normalizer miRNA in the same bodily fluid sample(s) as in step (a), wherein the normalizer miRNA is selected from the group consisting of miR-9, miR-181a, miR-127-3p, miR-370, miR-141, and miR-491-5p;
c. calculating the ratio of the level of the synapse or neurite miRNA measured in step (a) to the level of the normalizer miRNA measured in step (b) for each of the bodily fluid samples collected from the subject prior to a test compound administration;
d. measuring the level of the same synapse or neurite miRNA(s) as in step (a) in one or more bodily fluid samples collected from the subject following administration of the test compound, wherein the bodily fluid is selected from the group consisting of blood plasma, serum, urine, and saliva;
e. measuring the level of the same normalizer miRNA as in step (b) in the same bodily fluid sample(s) as in step (d);
f. calculating the ratio of the level of the synapse or neurite miRNA measured in step (d) to the level of the normalizer miRNA measured in step (e) for each of the bodily fluid samples collected from the subject following administration of the test compound;
g. comparing the ratios of the levels of the miRNAs calculated in steps (c) and (f), and
h. (i) identifying the test compound as a candidate compound for slowing down the progression of or treating pre-MCI or MCI if the ratio of the levels of the miRNAs calculated in step (f) is lower than the ratio of the levels of the miRNAs calculated in step (c); (ii) identifying the test compound as not a candidate compound for slowing down the progression of or treating pre-MCI or MCI if the ratio of the levels of the miRNAs calculated in step (f) is not lower than the ratio of the levels of the miRNAs calculated in step (c).
US Pat. No. 10,246,748

BIOMARKER COMBINATIONS FOR COLORECTAL TUMORS

NOVIGENIX SA, Epalinges ...

1. A method for detecting IL1B, PTGS2 and at least one of S100A8, LTF, CXCL10, and CACNB4, the method comprising:(a) extracting RNA from blood cells in peripheral blood from a selected subject to produce extracted RNA; and
(b) measuring in the extracted RNA the amount of mRNA for each biomarker in one biomarker panel, wherein the biomarker panel consists of from 3 to 29 biomarkers, wherein the 3 to 29 biomarkers comprise IL1B, PTGS2, and at least one of S100A8, LTF, CXCL10, and CACNB4,
wherein said method does not comprise measuring more than 29 biomarkers.
US Pat. No. 10,246,493

DE NOVO STRUCTURAL PROTEIN DESIGN FOR MANUFACTURING HIGH STRENGTH MATERIALS

The Penn State Research F...

1. A method of making a synthetic or recombinant polypeptide capable of forming at least a first crystal-forming domain block and at least a first amorphous domain block, the method comprising selecting an amino acid sequence that is capable of forming the first crystal domain block, wherein the crystal domain block is from about 2 nm to about 5 nm long and comprises from 10 to 30 amino acids, and selecting an amino acid sequence that is capable of forming a first amorphous domain block, wherein the first amorphous domain block is about 3 nm long and comprises about 15 amino acids, and forming the synthetic or recombinant polypeptide by incorporating [i] the amino acid sequence comprising AA[XXXXXX]HH (SEQ ID NO: 313), wherein the XXXXXX comprises histidine, threonine, valine, alanine, serine, or a combination thereof that is capable of forming the first crystal-forming domain block and [ii] the amino acid sequence comprising a glycine rich sequence according to Table 6 that is capable of forming the first amorphous domain block into the synthetic or recombinant polypeptide.
US Pat. No. 10,246,749

METHOD FOR DIAGNOSING BREAST CANCER

Albert-Ludwigs-Universita...

1. A method of diagnosing a subject with breast cancer, said method comprising the steps of:a. detecting and measuring the levels of the following four miR gene products: miR-21, miR125b, miR-451, and miR-155 in a cell-free test sample isolated from a whole urine sample obtained from said subject;
b. comparing the respective levels of each of said four miR gene products in the subject test sample detected and measured in step (a) with its corresponding miR gene product control level in a control sample; and
c. diagnosing with breast cancer the subject for whom the comparison of step (b) reveals a decrease in the respective levels of miR-21, miR-125b, and miR-451, and an increase in the level of miR-155 in the subject test sample measured in step (a) as compared to each corresponding control level,
wherein said cell-free test sample is a supernatant isolated from the whole urine sample, wherein the whole urine sample has been processed to eradicate contamination with any urothelial or microbiological cell material.
US Pat. No. 10,244,702

HYBRID CORN VARIETY 15711553

Agrigenetics, Inc., Indi...

1. A seed of the hybrid corn variety 15711553, produced by crossing a first plant of variety 3EESL0003 with a second plant of variety XHE06, wherein representative seed of said varieties 3EESL0003 and XHE06 have been deposited under ATCC Accession numbers PTA-123410 and PTA-12583, respectively.
US Pat. No. 10,246,503

METHOD OF IMPROVING THE PHARMACOKINETIC PROFILE OF A THERAPEUTIC POLYPEPTIDE AND THE USE THEREOF

BEIJING ANXINHUAIDE BIOTE...

1. A fusion protein comprising a therapeutic polypeptide (TP) fused to one or more pCloud sequences and a scaffold protein,wherein TP is human glucagon-like peptide or a functional variant thereof,
the scaffold protein forms a homo-trimer in solution and is selected from the group consisting of human collagen noncollagenous (NC) domains which form stable homo-trimers in solution, and
the pCloud sequence is a flexible un-structured polypeptide comprising some or all of the fragments of the human fibrinogen alpha chain; and
wherein the pCloud polypeptide sequence:
(a) comprises at least 100 to about 3000 amino acid residues;
(b) comprises some or all of the fragments derived from human fibrinogen alpha chain; wherein the fibrinogen alpha chain fragments are flanked by flexible loops with various lengths from 1 to 100 amino acid residues; wherein the flexible loops are rich in glycine (G) and serine (S), the flexible loops may also contain glutamate (E), alanine (A), proline (P) and threonine (T), the flexible loops have greater than 95% unstructured random coil formation as determined by GOR algorithm;
(c) is rich in glycine (G), serine (S) and glutamate (E), and optionally further comprising alanine (A), proline (P), arginine (R) and threonine (T), and wherein the sum of G, S, E, A, P and T amino acid residues constitutes more than 90% of the pCloud amino acid sequence;
(d) has greater than 90% unstructured random coil formation as determined by GOR algorithm; and
(e) does not contain a T-cell epitope as predicted by TEPITOPE algorithm;
wherein the pCloud sequence can be at either or both of the N-terminal and the C-terminal end of the therapeutic polypeptide, and the pCloud sequences can optionally be placed at either or both of the N-terminal and the C-terminal end of the scaffold protein; and
wherein the pCloud polypeptides can be identical or different to each other;
wherein the fusion protein is configured, from N-terminus to C-terminus, using the following formula:
(pCloud)m-TP-(pCloud)n-Scaffold-(pCloud)k, or
(pCloud)m-Scaffold-(pCloud)n-TP-(pCloud)k
wherein m is either 0 or 1, n is either 0 or 1, k is either 0 or 1, and m+n+k>=1, the digits indicate the number of presence of the designated polypeptides;
wherein m is either 0 or 1, n is either 0 or 1, k is either 0 or 1, and m+n+k>=1, the digits indicate the number of presence of the designated polypeptides; and
wherein the fusion protein exhibits an improved pharmacokinetic profile when administered to a subject compared with the TP by itself.
US Pat. No. 10,245,224

TOPICALLY APPLIED COSMETIC REDUCTIVE COMPOSITION CONTAINING KERATIN AND SULPHUR

Patricio Alfredo Rodrigue...

1. A topical, reductive cosmetic composition, comprising up to 15% by weight of hydrolyzed keratin and micrometer-sized Sulphur, and a remainder of the composition comprising water, compatibilizers, surfactants, thickeners, preservatives and/or flavoring agents.
US Pat. No. 10,245,226

METHOD FOR PREVENTING NASOLACRIMAL DUCT OBSTRUCTION

KEM PATENT HOLDINGS, LLC,...

1. A method for reducing formation of fibrosis in at least one nasolacrimal duct of a patient that may occur upon the patient receiving radioactive iodine, the method comprising administering to the patient a therapeutically effective amount of perchlorate anion, wherein the administering is topically administering perchlorate anion to at least one eye of the patient, or instilling the perchlorate anion directly into the at least one nasolacrimal duct or at least one lacrimal sac of the patient.
US Pat. No. 10,245,232

CRYSTALLINE MICROSPHERES AND THE PROCESS OF MANUFACTURING THE SAME

SPI PHARMA, INC., Wilmin...

1. A microsphere comprising a core material, wherein the microsphere has a circularity greater than 0.95 and an aspect ratio of shortest diameter to longest diameter that is greater than 0.95, wherein the microsphere has a skeletal density from about 1.4595 g/cc to about 1.4651 g/cc, and wherein the microsphere has a moisture gain of less than 1.0% at 90% relative humidity.
US Pat. No. 10,246,516

ANTI-LA ANTIBODIES AND THEIR USE FOR IMMUNOTARGETING

GEMoaB Monoclonals GmbH, ...

and(b) a binding unit comprising:
a second antibody which binds specifically to an effector cell or
a ligand which binds specifically to an effector cell.
US Pat. No. 10,246,517

ANTIBODY BINDING TO CARBONIC ANHYDRASE AND USE THEREOF

APROGEN KIC INC., Seongn...

1. An antibody or an antigen-binding fragment thereof, binding to carbonic anhydrase, wherein the antibody or antigen-binding fragment thereof comprises a CDR-H1 comprising SEQ ID NO: 14; a CDR-H2 comprising SEQ ID NO: 15; a CDR-H3 comprising SEQ ID NO: 16; a CDR-L1 comprising SEQ ID NO: 17; a CDR-L2 comprising SEQ ID NO: 18; and a CDR-L3 comprising SEQ ID NO: 19.
US Pat. No. 10,245,238

COMPOSITION FOR ORAL INTAKE

THERAVALUES CORPORATION, ...

1. A method for producing a complex of (A) curcumin and/or an analog thereof and (B) a water-soluble cellulose derivative selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, and a mixture thereof, wherein a weight ratio (A/B) is in a range of 0.02 to 10, the method comprising:dissolving the curcumin and/or the analog thereof and the water-soluble cellulose derivative in a water-organic solvent mixed solvent, to obtain a solution; and
removing water and the organic solvent from the solution.
US Pat. No. 10,245,239

ASTAXANTHIN ANTI-INFLAMMATORY SYNERGISTIC COMBINATIONS

LYCORED LTD., Beer Sheva...

1. A composition comprising: lycopene, astaxanthin and carnosic acid, wherein the molar concentration ratio of astaxanthin to carnosic acid is from 1:1 to 1:10.
US Pat. No. 10,246,520

ANTIBODY AGAINST ALOPECIA-INDUCING SUBSTANCE AS ANTIGEN, COMPOSITION AND PRODUCTION METHOD

OSTRICH PHARMA KK, Kyoto...

1. A haircare product comprising an ostrich antibody against a hair loss-inducing substance as an antigen, wherein the hair loss-inducing substance is an enzyme or hormone which is the cause of alopecia, and wherein the hair loss-inducing substance comprises 5?-reductase, dihydrotestosterone, or 5?-reductase and dihydrotestosterone.
US Pat. No. 10,246,521

COMPOUND TARGETING IL-23A AND B-CELL ACTIVATING FACTOR (BAFF) AND USES THEREOF

Boehringer Ingelheim Inte...

1. A compound comprising a first polypeptide and a second polypeptide, wherein:(A) said first polypeptide comprises:
(i) a light chain variable domain of a first immunoglobulin (VL1) specific for a first target protein;
(ii) a heavy chain variable domain of a second immunoglobulin (VH2) specific for a second target protein; and
(iii) a hinge region, a heavy chain constant region 2 (CH2) and a heavy chain constant region 3 (CH3); and
(B) said second polypeptide comprises:
(i) a light chain variable domain of the second immunoglobulin (VL2) specific for said second target protein;
(ii) a heavy chain variable domain of the first immunoglobulin (VH1) specific for said first target protein;
wherein:
a) said VL1 and VH1 associate to form a binding site that binds said first target protein;
b) said VL2 and VH2 associate to form a binding site that binds said second target protein;
c) said heavy chain constant region 2 (CH2) comprises a tyrosine at position 252, a threonine at position 254 and a glutamic acid a position 256, numbered according to the EU index as in Kabat for the CH2 of a conventional antibody; and
d) said first target protein is B-cell activating factor (“BAFF”) and said second target protein is Interleukin-23A (“IL-23A”) or said first target protein is IL-23A and said second target protein is BAFF,
and wherein:
(i) said VL1 comprises the amino acid sequence of SEQ ID NO:2, said VH1 comprises the amino acid sequence of SEQ ID NO:1, said VL2 comprises the amino acid sequence of SEQ ID NO:4 and said VH2 comprises the amino acid sequence of SEQ ID NO:3; or
(ii) said VL1 comprises the amino acid sequence of SEQ ID NO:4, said VH1 comprises the amino acid sequence of SEQ ID NO:3, said VL2 comprises the amino acid sequence of SEQ ID NO:2 and said VH2 comprises the amino acid sequence of SEQ ID NO:1; or
(iii) said VL1 comprises the amino acid sequence of SEQ ID NO:89, said VH1 comprises the amino acid sequence of SEQ ID NO:88, said VL2 comprises the amino acid sequence of SEQ ID NO:4 and said VH2 comprises the amino acid sequence of SEQ ID NO:3; or
(iv) said VL1 comprises the amino acid sequence of SEQ ID NO:4, said VH1 comprises the amino acid sequence of SEQ ID NO:3, said VL2 comprises the amino acid sequence of SEQ ID NO:89 and said VH2 comprises the amino acid sequence of SEQ ID NO:88; or
(v) said VL1 comprises the amino acid sequence of SEQ ID NO:91, said VH1 comprises the amino acid sequence of SEQ ID NO:90, said VL2 comprises the amino acid sequence of SEQ ID NO:4 and said VH2 comprises the amino acid sequence of SEQ ID NO:3; or
(vi) said VL1 comprises the amino acid sequence of SEQ ID NO:4, said VH1 comprises the amino acid sequence of SEQ ID NO:3, said VL2 comprises the amino acid sequence of SEQ ID NO:91 and said VH2 comprises the amino acid sequence of SEQ ID NO:90.
US Pat. No. 10,245,242

NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE R-ENANTIOMER AND METHODS OF USE

AXCESS GLOBAL SCIENCES, L...

1. A composition for increasing ketone body level in a subject, comprising:a non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate,
wherein the non-racemic mixture contains from 55% to 98% by enantiomeric equivalents of the R-beta-hydroxybutyrate and 45% to 2% by enantiomeric equivalents of the S-beta-hydroxybutyrate,
wherein the non-racemic mixture comprises one or more salts of R-beta-hydroxybutyrate.
US Pat. No. 10,246,778

ELECTROLESS NICKEL PLATING SOLUTION AND METHOD

MacDermid Acumen, Inc., ...

17. A process of plating a substrate to provide a bright electroless nickel deposit thereon, the method comprising the steps of:a) preparing a substrate to accept electroless nickel plating thereon; and
b) plating the substrate with an electroless nickel plating solution, the electroless nickel plating solution comprising;
1) a source of nickel ions;
2) a reducing agent;
3) one or more complexing agents, the one or more complexing agents in a concentration of about 15 to about 75 g/L;
4) one or more bath stabilizers, the one or more bath stabilizers comprising a source of bismuth ions;
5) a brightener selected from the group consisting of alkyl or aryl substituted sulfonamides, alkyl or aryl substituted sulfonic acids, alkyl or aryl substituted sulfosuccinates, and alkyl or aryl substituted sulfonates, the sulfonated compound in a concentration of about 0.1-3.0 mg/L; and
6) 2-aminothiazole;wherein the deposited electroless nickel layer has a measured gloss unit value above about 170.
US Pat. No. 10,245,243

NON-RACEMIC BETA-HYDROXYBUTYRATE COMPOUNDS AND COMPOSITIONS ENRICHED WITH THE S-ENANTIOMER AND METHODS OF USE

AXCESS GLOBAL SCIENCES, L...

1. A composition for administering ketone bodies and ketone body precursors to a subject, comprising:a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate,
wherein the non-racemic mixture comprises from 52% to 85% by enantiomeric equivalents of the S-beta-hydroxybutyrate and 48% to 15% by enantiomeric equivalents of the R-beta-hydroxybutyrate.
US Pat. No. 10,245,246

?-SUBSTITUTED ?-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS

QUADRIGA BIOSCIENCES, INC...

1. A method of treating cancer in a patient comprising administering to a patient in need of such treatment a therapeutically effective amount of (3S)-3-amino-4-[5-[bis(2-chloroethyl)amino]-2-methyl-phenyl]butanoic acid (5), or a pharmaceutically acceptable salt thereof, wherein the cancer comprises glioblastoma, triple negative breast cancer, melanoma, prostate cancer, or multiple myeloma.
US Pat. No. 10,246,530

METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION AND A PROCESS FOR PROPYLENE POLYMERIZATION

TOHO TITANIUM CO., LTD., ...

1. A method for producing an olefin polymerization catalyst component, the method comprising:bringing a magnesium compound, a tetravalent titanium halide compound, an organic compound represented the following general formula (1)
R1k(C6H4-k)(COOR2)(COOR3)  (1) andan organic compound represented the following general formula (2)R4R5C?C(COOR6)(COOR7)  (2)into contact with each other at the same step,wherein R1 is a halogen atom or an alkyl group having 1 to 8 carbon atoms, R2 and R3 are a linear alkyl group having 1 to 6 carbon atoms, provided that R2 and R3 are either identical or different, and k is an integer from 0 to 4, provided that a plurality of R1 are either identical or different when k is an integer from 2 to 4, andwherein R4 and R5 are independently an atom or group selected from a hydrogen atom, halogen, a linear alkyl group having 1 to 20 carbon atoms, a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, a linear or branched alkenyl group having 3 to 20 atoms, a cycloalkenyl group having 3 to 20 carbon atoms, an aromatic hydrocarbon group having 6 to 20 carbon atoms, provided that R4 and R5 optionally bond to each other to form a ring, and the number of carbon atoms of R5 is 2 or more when R4 is a hydrogen atom or a methyl group; andwherein R6 and R7 are independently a linear alkyl group having 1 to 20 carbon atoms, a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, a linear or branched alkenyl group having 3 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a cycloalkenyl group having 3 to 20 carbon atoms, or an aromatic hydrocarbon group having 6 to 20 atoms.
US Pat. No. 10,245,257

ANTI-INFECTIVE METHODS, COMPOSITIONS, AND DEVICES

Dow Pharmaceutical Scienc...

1. A method of treating onychomycosis comprising applying a pharmaceutically acceptable efinaconazole formulation once a day for a treatment period of at least 36 weeks to the treatment area of an onychomycosis patient (a) without debriding the nail or nail-associated tissue in the treatment area initially or during the treatment period and/or (b) without removing the formulation from the treatment area during the treatment period,wherein the efinaconazole formulation comprises 10% w/w efinaconazole, water, cyclomethicone, diisopropyl adipate, alcohol, C12-15 alkyl lactate, butylated hydroxytoluene, citric acid anhydrous, and disodium edetate,
wherein the amounts of butylated hydroxytoluene and disodium edetate are sufficient to ensure the formulation is (i) colorless upon initial manufacturing of the formulation and (ii) colorless or pale yellow after storage for three weeks at a temperature of about 40° C.,
wherein the average amount of efinaconazole delivered to each cm2 of the treatment area is about 0.15 mg/cm2 to about 0.45 mg/cm2,
and wherein applying the formulation results in a mean plasma Cmax in a population of at least 15 adult onychomycosis patients after 28 days of once daily treatment that is less than 0.8 ng/mL.
US Pat. No. 10,246,538

PHOTOCURABLE RESIN COMPOSITION, CURED PRODUCT OF SAME AND METHOD FOR PRODUCING CURED PRODUCT

THREE BOND CO., LTD., Ha...

1. A photocurable resin composition comprising the following component (A) to component (D):component (A): a leuco dye;
component (B): a photoacid generating agent;
component (C): a radical polymerizable compound; and
component (D): an ?-hydroxy acetophenone-based radical initiator having thermal decomposition temperature of 200° C. or higher.
US Pat. No. 10,244,758

COMPOSITIONS COMPRISING A GERMINANT AND AN ANTIMICROBIAL AGENT

Insight Health Limited, ...

1. A method of sterilising or disinfecting an abiotic surface such that it is essentially free of pathogens, the method comprising: contacting the abiotic surface with an antiseptic composition comprising a germinant and an antimicrobial agent, wherein the germinant comprises sodium taurocholate and at least two amino acids selected from the group consisting of histidine, arginine, aspartic acid, glycine and valine, and wherein the antimicrobial agent comprises benzalkonium chloride and benzyl alcohol;wherein the abiotic surface is contacted for a sufficient time for the pathogens to germinate and be killed;
wherein the antimicrobial agent is provided in an amount of from 0.01% to 2%;
wherein the amino acids are in an amount of from about 10 to about 100 mM based on the final composition;
wherein the antiseptic composition prevents sporulation of vegetative cells.
US Pat. No. 10,246,806

ECONOMICAL FIRE BARRIER NONWOVEN

TINTORIA PIANA US, INC., ...

1. A fire barrier nonwoven, comprising:10-80 wt % of at least one flame retardant (FR) cellulosic fiber, wherein said at least one FR cellulosic fiber contains or is treated with FR chemicals or FR compounds having a melting point or decomposition temperature at 400° C. (752° F.) or below; and
10-80 wt % of at least one untreated cellulosic fiber, said at least one untreated cellulosic fiber being the same or different cellulosic fiber used to make said FR cellulosic fiber,
wherein said at least one untreated cellulosic fiber is selected from the group consisting of cotton, kapok, flax, ramie, kenaf, abaca, coir, hemp, jute, sisal, pineapple, rayon, lyocell, and bamboo, and
wherein said at least one FR cellulosic fiber and said at least one untreated cellulosic fiber are assembled together as a fiber barrier nonwoven material.
US Pat. No. 10,244,759

USE OF FORCHLORFENURON FOR PROMOTING PLANT GROWTH

KIM-C1, LLC, Fresno, CA ...

1. A method of promoting root growth of a plant, the method comprising contacting the plant, or a seed of the plant, with a composition comprising forchlorfenuron (CPPU) before the reproductive growth stage of the plant, such that either the root length of the plant is at least 5% greater than for an untreated plant, or the ratio of root length to stem length is increased by at least 5% compared to the untreated plant, wherein the plant is a member of the genus Gossypium, wherein the concentration of CPPU in the composition is from about 2 to about 50 ppm when the plant is contacted, and wherein the concentration of CPPU in the composition, is from about 25 to about 1000 ppm in the composition when the seed is contacted.
US Pat. No. 10,245,273

ORAL PHARMACEUTICAL PRODUCTS AND METHODS OF USE COMBINING TESTOSTERONE ESTERS WITH HYPOLIPIDEMIC AGENTS

Clarus Therapeutics, Inc....

1. A oral pharmaceutical composition comprising:a. a hypolipidemic agent that is a peroxisome proliferator activating receptor (PPAR) agonist; and
b. 18 to 22 percent by weight of solubilized testosterone undecanoate, solubilized in a carrier comprising
i. 15 to 17 percent by weight of hydrophilic surfactant;
ii. 50 to 55 percent by weight of lipophilic surfactant; and
iii. 10-15 percent by weight of a mixture of borage oil and peppermint oil.
US Pat. No. 10,244,762

SOLID AQUATIC ORGANISM CONTROL COMPOSITION AND METHOD OF USE

Arch Chemicals, Inc., Al...

1. A solid aquatic organism control composition comprising:a hydrogen peroxide producing compound capable of releasing hydrogen peroxide when contacted with an aqueous medium;
a chelating agent comprising an aminocarboxylate;
a peroxide enhancing agent comprising a carboxylic acid or salt thereof, a hydroxyl-containing compound, a compound containing a cuprous ion, or combinations thereof; and
wherein the hydrogen peroxide producing compound is present in the composition in an amount greater than or equal to about 85% by weight and the chelating agent is present in the composition in an amount of from about 0.1% to about 1.5% by weight.
US Pat. No. 10,245,277

COMPOSITIONS, METHODS OF TREATMENT AND DIAGNOSTICS FOR TREATMENT OF HEPATIC STEATOSIS ALONE OR IN COMBINATION WITH A HEPATITIS C VIRUS INFECTION

VOLANT HOLDINGS GMBH, (C...

1. A method of treating hepatic steatosis in a patient comprising orally administering an effective amount of an ileal brake composition in an oral dosage form comprising an ileal brake compound wherein at least 50% by weight of the ileal brake compound administered to said patient is released in the ileum of the patient.
US Pat. No. 10,246,559

METHOD FOR PREPARING SILICONE RESINS CONTAINING HYDROXY GROUPS AND ALKOXY GROUPS

WACKER CHEMIE AG, Munich...

1. A process for preparing silicone resins bearing hydroxy groups and alkoxy groups, comprising:reacting at a temperature of at least 50° C. and for at least 30 minutes,
a) 100 parts by weight of alkoxysilane,
b) from 0.01 to 1 parts by weight of hydrocarbon containing, based on alkoxysilane, from 10 to 2000 ppm by weight of Cl, and
c) water
without the addition of organic solvent(s) which at 0.1 MPa and 20° C. are soluble to a maximum extent of 1% by weight in water.
US Pat. No. 10,245,280

USE OF HYALURONIC ACID FOR PREPARING COMPOSITIONS FOR TREATING ORAL CAVITY APHTHAS

Bioplax Limited, London ...

1. A method of reducing the number of ulcers in a subject having an episode of Recurrent Oral Aphthous Ulcers (ROAU) said method comprising the steps of:selecting a subject having an episode of ROAU; and
administering, repeatedly to the selected subject, from the first day to the seventh day of the episode of ROAU, a composition comprising between 0.01 and 1% by weight hyaluronic acid or a salt thereof, said hyaluronic acid or salt thereof being the sole active ingredient and having an average molecular weight of between 800,000 and 4,000,000,
wherein said composition is administered in an amount sufficient to reduce the number of ulcers in the subject by the fifth day of said single episode.
US Pat. No. 10,244,769

METHOD OF CUTTING A PORK LOIN AND A BONELESS PORK LOIN PRODUCT

Tyson Foods, Inc., Sprin...

1. A method of cutting a boneless elongated meat member, the elongated meat member being the loin of a hog carcass in substantially the shape of a cylinder, the elongated meat member having a first end, a second end, and a longitudinal axis between the first and second ends, the method comprising:separating the boneless elongated meat member into at least three elongated meat portions and each of the at least three elongated meat portions have a first end, a second end, and a longitudinal axis between the first and second ends, wherein two of the at least three elongated meat portions are exterior elongated meat portions and each exterior elongated meat portion is substantially in the shape of a half-cylinder, and at least one of the at least three elongated meat portions is an interior elongated meat portion positioned between the two exterior elongated meat portions and the interior elongated meat portion is substantially in the shape of a rectangular prism that includes a top surface, a bottom surface opposite the top surface, and four exterior side surfaces between the top and bottom surfaces, wherein two of the four exterior side surfaces are elongated side surfaces each running the length of the interior elongated meat portion and wherein each of the elongated side surfaces are opposite each other, and two of the four exterior side surfaces are short side surfaces positioned between the elongated side surfaces and wherein one short side surface is at the first end and the other is at the second end of the interior elongated meat portion, and wherein the short side surfaces substantially define a width of the interior elongated meat portion and wherein a thickness of the interior elongated meat portion is substantially defined between the top and bottom surfaces, wherein the separating step includes cutting the elongated meat member end to end in substantially the same direction of the longitudinal axis the length of the elongated meat member, wherein the at least three elongated meat portions are each about 0.0625 inches to about 4.0 inches thick; and
dividing the at least one interior elongated meat portion into a plurality of smaller meat pieces, wherein the dividing step includes cutting the at least one interior elongated meat portion substantially perpendicular with respect to the longitudinal axis of the interior elongated meat portion and between the top and bottom surfaces in the same direction as its thickness.
US Pat. No. 10,246,562

PLASTICS COLOURATION

DATALASE LTD., Cheshire ...

1. A method of imparting colour to a plastic substrate, wherein the plastic substrate is selected from packaging, product wrapping films, and melt spun fibres, wherein the plastic substrate is polycaprolactone (PCL) or low density polyethylene (LDPE), wherein said method comprises applying to the substrate, or incorporating within the substrate, a diacetylene compound of general formula (I)R1Q1-C(?O)—(CH2)n—C?C—C?C—(CH2)n—C(?O)-Q1R1  (I)
wherein
n =1 to 20;
Q1=NH or NR3,
R3 is an optionally substituted C1-20 alkyl group which may contain heteroatoms; and irradiating the substrate to impart colour to the substrate;
wherein R1 is a saturated aliphatic hydrocarbon group having a chain length of 8 to 20 carbon atoms,
wherein the diacetylene compound is initially applied to the plastic substrate or incorporated within the plastic substrate in an inactive form, and is subsequently activated by an activating stimulus, prior to being irradiated to impart colour to the plastic substrate,
wherein the activating stimulus is selected from heat at a temperature about or above the melting point of the diacetylene compound and near-infrared light in a wavelength range of 700 nm to 2500 nm, and
wherein, when the activating stimulus is near-infrared light, the plastic substrate further comprises a near-infrared light absorbing agent.
US Pat. No. 10,246,822

TEXTILE PRINTING PAPER FOR USE IN PAPER PRINTING METHOD

MITSUBISHI PAPER MILLS LI...

1. A textile printing paper comprising:a base paper and a glue layer on a surface of the base paper, wherein
the base paper has a swelling rate of 130 to 180% by mass, and
dye fixing treatment is performed on the textile printing paper in such a state that a printed paper is kept stuck to a printing substrate.
US Pat. No. 10,246,569

RECYCLING OF FIBROUS SURFACE COVERINGS

GEO-TECH POLYMERS, LLC, ...

1. A process mixture, comprising:a fibrous surface covering in contact with a single phase aqueous solution;
the fibrous surface covering comprising:
a fibrous surface layer;
a first backing coupled to the fibrous surface layer;
a binder coupled to one or more of the first backing and the fibrous surface layer; and
the single-phase aqueous solution comprising:
water;
a surfactant composition, the surfactant composition consisting essentially of one or more alkyl polyglycosides in a weight percentage (w/w) with respect to the water of about 0.01% to 0.5%;
an inorganic base composition;
a stable peroxygen composition; and
a monosaccharide salt,the process mixture characterized by a pH value of about 10 to about 14.
US Pat. No. 10,245,290

PROBIOTIC STRAINS FOR USE IN TREATMENT OR PREVENTION OF OSTEOPOROSIS

Probi AB, Lund (SE)

1. A method for treating or inhibiting osteoporosis, treating or inhibiting bone loss, or increasing the absorption of Ca2+ ions, comprising orally administering to a mammal a composition comprising a therapeutically effective amount of at least one probiotic strain selected from the group consisting of Lactobacillus paracasei 8700:2, DSM 13434, and Lactobacillus paracasei 02:A, DSM 13432, wherein the composition is supplemented with additional Ca2+ in the form of a salt, wherein the inhibition of osteoporosis or bone loss is by reducing osteoporosis or bone loss compared to osteoporosis or bone loss without administration of said composition, and wherein increasing the absorption of Ca2+ ions is compared to absorption of Ca2+ ions without administration of said composition.
US Pat. No. 10,245,292

COMPOSITION FOR ENHANCING MALE SEX HORMONE AND MEN'S HEALTH

FAMENITY CO., LTD, Gwach...

1. A method of reducing the instance of, improving, or treating male climeractic disorder and symptoms thereof comprising:administering an effective amount of a composition comprising a dandelion extract and a rooibos extract to a subject with male climeractic disorder, wherein the dandelion and rooibos extracts are obtained by extraction with a solvent selected from the group consisting of water, alcohol, and a mixture thereof; wherein the weight ratio of the dandelion extract and the rooibos extract is 4:1-1:9; and wherein the amount of the dandelion extract, or dandelion extract and rooibos extract, administered is from 0.01 mg/day/kg to 100 mg/day/kg of body weight.
US Pat. No. 10,246,829

COATING OF COMPOSITE WOOD PANELS WITH AMINOPLAST RESIN FILMS FITTED WITH AN ABRASION-RESISTANT, EASY-CLEAN AND HYDROPHOBIC SURFACE

HUECK Rheinische GmbH, V...

1. A method comprising:providing decorative and/or overlay papers,
impregnating the decorative and/or overlay papers with aminoplast resin to form impregnated papers,
after the impregnation, coating the impregnated papers with a sol-gel preparation comprising:
dissolved metal alkoxides,
fullerene-like nanostructures made of metal disulfides of molybdenum and/or tungsten, and
fullerene-like nanotubes made of metal disulfides of molybdenum and/or tungstensuch that coated papers are formed,drying the coated papers to form dried papers, and
pressing the dried papers in a hydraulic heating press such that the dried papers are condensed and such that an abrasion-resistant, hydrophobic surface is formed on the dried papers so that finished papers are formed.
US Pat. No. 10,245,294

DIETARY SUPPLEMENT

GRATUK TECHNOLOGIES PTY L...

1. A method of treatment of the effects of chronic inflammation and associated conditions in an individual by feeding to said individual a food product incorporating dietary fibre material derived from whole sugar cane, whole sweet sorghum or whole bamboo; said dietary fibre material having been prepared according to a method including the steps of:subjecting the dietary fibre material to at least one wet diffusion step at neutral pH and a temperature is in the range of 25° C. to 70° C., to separate unwanted macronutrients including carbohydrates, fats and proteins, from a residual fibre material of the dietary fibre material whilst maintaining bioactive micro-nutrient content including polyphenolic antioxidants and flavonoid antioxidants; and
subjecting the residual fibre material to a drying process that does not induce significant breakdown of the bioactive micronutrients retained by the chemical free extraction.
US Pat. No. 10,245,295

NEUROLOGICAL ESSENTIAL OIL COMPOSITION AND METHODS

Laura Harris Smith

1. A composition of eight essential oils containing sesqiterpene compounds as active ingredients for therapeutic relief of neurological ailments, said composition comprising 2-18% oil from the grasses of Vetiveria zizanioides, 7-23% oil from the flowers of Cananga odorata, 7-23% oil from the wood of Santalum spicatum trees, 11-27% oil from the leaves of Pogostemon cablin, 5-31% oil from the wood of Juniperus virginiana, 7-23% oil from the resin of Commiphora myrrha, oil from the resin of Boswellia carterii trees, and 5-25% oil from the flowers of Lavandula officinalis.
US Pat. No. 10,246,578

COMPOSITE MATERIAL FROM WASTE AND AT LEAST ONE ELEMENT OF VULCANIZED RUBBER AND TIRE CORDS

UBQ Materials Ltd., Peta...

1. A process comprising:extruding a first component comprising organic waste and thermoplastic waste with a second component comprising vulcanized rubber and optionally tire cords to obtain a melt;
processing the melt, the processing comprises at least cooling the melt to obtain a composite material, the composite material comprising:
a non-plastic organic element;
a thermoplastic element; and
at least one element comprising vulcanized rubber and optionally tire cords;
wherein an amount by weight of the non-plastic organic element is at least 10% w/w out of a total weight of a combined amount of the first component and the second component;
wherein an amount by weight of the thermoplastic element is up to 40% w/w out of the total weight of the combined amount of the first component and the second component; and
wherein an amount by weight of the vulcanized rubber is at least 40% w/w out of the total weight of the combined amount of the first component and the second component.
US Pat. No. 10,246,581

RUBBER COMPOSITIONS CONTAINING WHEY PROTEIN

Bridgestone Americas Tire...

1. A rubber composition comprising:a. at least one of a butyl rubber or a halogenated butyl rubber;
b. at least one filler in an amount of about 5 to about 200 phr; and
c. a whey protein component in an amount sufficient to provide about 0.1 to about 10 phr whey protein,
wherein the whey protein meets all of the following:
d. a majority of the protein chains in the whey protein have a molecular weight of greater than about 10 kDaltons;
e. a majority of the proteins in the whey protein are a combination of alpha-lactalbumin and beta-lactoglobulin; and
f. a degree of hydrolysis of less than 50%.
US Pat. No. 10,245,303

COMPOSITIONS AND METHODS FOR ENZYMATIC TREATMENT OF LUNG DISORDERS

Laclede, Inc., Rancho Do...

1. A method of treating a lung disease or condition comprising the step of administering to a patient suffering from the lung disease or condition, a therapeutic composition comprising:(a) a peroxidase enzyme being present in a sufficient quantity such that the biocide is produced in a therapeutically effective concentration;
(b) a salt, wherein the salt is an alkali metal salt of an anion of thiocyanate, iodate and chlorate; and
(c) an aqueous medium in which the peroxidase enzyme and the salt that acts as an oxygen acceptor are stable,wherein the therapeutic composition is administered by a route in which the ingredients of the composition reach the lungs and generate the biocide within the lungs to treat the lung disease or condition.
US Pat. No. 10,245,306

FLEXIBLE TISSUE MATRIX AND METHODS FOR JOINT REPAIR

ISTO TECHNOLOGIES II, LLC...

1. A tissue matrix for supporting repair of biological tissues comprising total polymers comprising a caprolactone polymer and at least one additional polyester polymer other than a caprolactone polymer which is not copolymerized with the caprolactone polymer, wherein the total polymers are entangled with a polysaccharide following combination of the total polymers and the polysaccharide in a dual solvent emulsion, said dual solvent emulsion being formed by the steps of:i. dissolving the total polymers in an organic solvent;
ii. dissolving the polysaccharide in an aqueous solvent;
iii. blending the total polymers in the organic solvent with the polysaccharide in an aqueous solvent to form the dual solvent emulsion; and
iv. removing the organic solvent and aqueous solvent from the emulsion to form a flexible matrix comprising the total polymer molecules entangled with polysaccharide polymer molecules;
wherein the weight ratio of the polyester polymer to the caprolactone polymer ranges from about 1:1 to about 4:1.
US Pat. No. 10,245,311

ADJUVANTING MENINGOCOCCAL FACTOR H BINDING PROTEIN

GlaxoSmithKline Biologica...

1. A method for raising an immune response in a human comprising administering to the human a buffered immunogenic composition comprising at least two different meningococcal fHBP antigens, both of which are at least 85% adsorbed to aluminium hydroxyphosphate adjuvant.
US Pat. No. 10,245,314

NON-SPECIFIC DELAYED-TYPE HYPERSENSITIVITY RESPONSE TO TREAT HERPES SIMPLEX VIRUS INFECTION

Squarex, LLC, Pine Sprin...

1. A method of treating herpes simplex virus (HSV) infection comprising:an administering step comprising:
applying a topical immunosensitizer to the skin of a person infected with HSV at a time when the person is not having an HSV outbreak, or applying a topical immunosensitizer to the skin of a person infected with HSV during an HSV outbreak wherein the applying is at a site other than a site of an HSV lesion;
wherein the method does not further comprise (i) applying a topical immunosensitizer to the skin of a person infected with HSV on an HSV lesion at a time of an HSV outbreak in the person; or (ii) intradermally injecting a recall antigen into a person infected with HSV in an HSV lesion at the time of an HSV outbreak in the person;
wherein the method reduces the frequency of HSV outbreaks in the person after the administering step;
wherein the person has had HSV outbreaks before the administering step and is in recognized need of treatment for HSV infection;
wherein the administering step comprises applying the topical immunosensitizer to skin on the forearm or on the inner aspect of the upper arm of the person;
wherein the topical immunosensitizer comprises squaric acid dibutyl ester (SADBE); and
wherein the person has herpes labialis.
US Pat. No. 10,245,318

FLAGELLIN-CONTAINING PROTEIN NANOPARTICLES AS A VACCINE PLATFORM

ALPHA-O PEPTIDES AG, Rie...

1. A self-assembling protein nanoparticle consisting of aggregates of a multitude of building blocks of formula (Ia) or (Ib)X-ND1-L1-ND2-FLA  (Ia)
or
FLA-ND1-L1-ND2-X  (Ib),
consisting of a continuous chain comprising a protein oligomerization domain ND1, a linker L1, a protein oligomerization domain ND2, FLA, and a further substituent X, wherein
ND1 is a protein that forms oligomers (ND1)m of m subunits ND1,
ND2 is a protein that forms oligomers (ND2)n of n subunits ND2,
m and n each is a figure between 2 and 10, with the proviso that m is not equal to n and not a multiple of n, and n is not a multiple of m,
L1 is a bond or a short flexible linker,
FLA is flagellin, or a derivative of flagellin lacking parts of the flagellin amino acid sequence but at least containing the TLR5 binding domain D1, and wherein the lacking parts are (a) replaced by a flexible linker segment of 1 to 20 amino acids joining two ends of the flagellin amino acid sequence or (b) are replaced by a fully folded protein antigen;
X is absent or a peptide or protein sequence comprising 1 to 1000 amino acids,
optionally co-assembled with a multitude of building blocks of the formula (II)
Y-ND3-L2-ND4-Z  (II),
consisting of a continuous chain comprising a protein oligomerization domain ND3, a linker L2, a protein oligomerization domain ND4, and further substituents Y and Z, wherein
ND3 is a protein that forms oligomers (ND3)y of y subunits ND3,
ND4 is a protein that forms oligomers (ND4)z of z subunits ND4,
y and z each is a figure between 2 and 10, with the proviso that y is not equal to z and not a multiple of z, and z is not a multiple of y, and wherein
either ND3 is identical to ND1, or ND4 is identical to ND2 or both ND3 and ND4 are identical to ND1 and ND2, respectively,
L2 is a bond or a short flexible linker that may be different from L1 or identical to L1, and
Y and Z are, independently of each other, absent or a peptide or protein sequence comprising 1 to 1000 amino acids.
US Pat. No. 10,245,590

HIGH-SPEED REAL-TIME PCR DEVICE BASED ON LAB-ON-A-CHIP FOR DETECTING FOOD-BORNE BACTERIA TO AGRIFOOD, AND METHODS FOR DETECTING FOOD-BORNE BACTERIA TO AGRIFOOD USING THE SAME

NANOBIOSYS INC., Seoul (...

1. A micro Polymerase Chain Reaction (PCR) chip, comprising: a reaction chamber having an opened upper surface intended to receive a fluid; and a cover intended to seal the reaction chamber, the cover comprising a light-transmitting portion of a light transmitting material which is faced with the opened upper surface of the PCR reaction chamber to close the open upper surface, the light-transmitting portion having a protruding part that extends toward the interior of the reaction chamber from regions of closed surfaces faced on the opened upper surface of the chamber, and the end of the protruding part being adjacent to or in contact with the surface of said fluid, wherein the protruding part of the light-transmitting portion is located in an optical path between a light-emitting module and a light-detecting module for detecting optical signals in said fluid.
US Pat. No. 10,246,614

STARCH-BASED GLUE COMPOSITION

ARGANA STAERKE GMBH, Gmu...

1. A method of preparing a layered or laminated product, which comprises the steps of:providing a glue composition having an enzymatically branched starch with a viscosity stability index SI of less than or equal to 1.3, calculated by a quotient from viscosity after 14 days and the viscosity after 2 hours after preparation of the glue composition, wherein said starch has a mean molecular weight Mw (weight average), measured by light scattering, of from 60 kDa to 3000 kDa; and
applying the glue composition as a gluing agent or a laminating agent to two surfaces of at least one of paper products, cardboard products, and displays made from paper or cardboard, wherein the glue composition bonds the two surfaces together to form a layered or laminated product.
US Pat. No. 10,245,356

MEDICAL DEVICES WITH NON-UNIFORM COATINGS FOR ENHANCED ECHOGENICITY

ENCAPSON B.V., Enschede ...

1. A medical device comprising a coating for ultrasound detection, said coating comprising microparticles that are visible with ultrasound, wherein the microparticles are solid throughout, wherein the diameter of at least 60% of said microparticles on said medical device is between 10 and 45 ?m and the density of said microparticles per surface area is between 45 and 450 particles/mm2, and wherein said coating is applied as a pattern that spatially selectively covers parts of the surface.
US Pat. No. 10,246,397

PROCESS FOR PRODUCTION OF KETONES FROM SECONDARY ALCOHOLS

Instituto Superior Tecnic...

1. A process for production of ketones from secondary alcohols, assisted by microwave radiation comprising the mixture of an oxidising agent with a hybrid, material dichlorohydrotris (pyrazol-1-yl) methane iron (II) covalently bound to multi-walled carbon nanotubes functionalized with superficial carboxylate groups as catalyst, at a temperature of 80° C.
US Pat. No. 10,246,399

PROCESS FOR PRODUCING ACETIC ACID

DAICEL CORPORATION, Osak...

1. A process for producing acetic acid, comprising:(1) allowing methanol to carbonylation react with carbon monoxide in the presence of a catalyst system, acetic acid, methyl acetate, and water, wherein the catalyst system comprises a metal catalyst, an ionic metal iodide, and methyl iodide;
(2) separating the reaction mixture into a volatile phase and a less-volatile phase;
(3) distilling the volatile phase to form a first overhead and an acetic acid stream, wherein the first overhead is rich in at least one lower boiling component selected from the group consisting of methyl iodide and acetaldehyde, and the acetic acid stream is rich in acetic acid; and
at least one section selected from the group consisting of the following sections (4), (9), and (15):
(4) a purification section for obtaining purified acetic acid from the acetic acid stream;
(9) a separation section for separating at least acetaldehyde from the first overhead; and
(15) an off-gas treatment section for absorption-treating an off-gas from the process with an absorption solvent and forming a carbon monoxide-rich stream and an acetic acid-rich stream;
wherein a concentration of oxygen is controlled in at least one selected from the group consisting of the following (a) and (b):
(a) the concentration of oxygen in a gaseous phase of the process is controlled to less than 7% by volume,
(b) the concentration of oxygen in a liquid phase of the process is controlled to less than 7×10?5 g/g.
US Pat. No. 10,246,669

METHOD FOR PRODUCING HYPOALLERGENIC PEANUT PRODUCTS

Molecular Epidemiology In...

1. A method of decontaminating machinery contaminated with allergen residues, comprising: contacting machinery contaminated with seeds of legumes, peanuts or tree nuts, or unground pieces or particles thereof, having Ara h3 allergen with an aqueous solution of bromelain in an amount and for a time period sufficient to reduce or eliminate the allergenicity of the Ara h3 allergen.
US Pat. No. 10,246,681

REPROGRAMMING OF HUMAN WHARTON'S JELLY CELLS TO PRODUCE HAIR CELLS

The University of Kansas,...

1. A cell culture system comprising:a decellularized cochlea; and
mechanosensory hair cells (MHCs) growing on and/or inside the decellularized cochlea, wherein the MHCs have an exogenous nucleic acid that encodes HATH1 and a promoter operably linked with the encoded HATH1.
US Pat. No. 10,246,683

METHOD AND ASSEMBLY FOR EXTRACTION OF REGENERATIVE CELLULAR COMPONENTS FROM ADIPOSE TISSUE

MyStem Limited, Nicosia ...

1. A method for extracting regenerative cellular components from adipose tissue comprising the steps of:a) filtering a harvested adipose tissue for recovering its liquid fraction by means of a filtering element having a first cut-off value between 40 microns and 70 microns;
b) separating regenerative cellular components present in the liquid fraction by means of cell size segregation, which blocks cells bigger than a second cut-off value ranging from 8 to 20 microns; and
c) recovering the liquid regenerative cells-rich fraction comprising the regenerative cellular components not having being blocked during the separating step b);wherein steps a)-c) are carried out in a time ranging from 1 to 5 minutes.