US Pat. No. 10,191,225

OPTICAL CONNECTOR

Yazaki Corporation, Toky...

1. An optical connector comprising:a connection end part to be provided at a tip end of an optical fiber;
a housing which houses the connection end part and includes an opening part in a top surface;
a lid part which is attached to the housing so as to cover the opening part; and
a plate-shaped pressure crimping member which includes a recess part where the optical fiber is placed,
wherein
the plate-shaped pressure crimping member is provided in such a manner that an opening of the recess part opens toward a bottom surface of the housing, and
the plate-shaped pressure crimping member is configured such that when the lid part is attached to the housing, the optical fiber is sandwiched and pressed between the pressure crimping member and the bottom surface, such that the optical fiber is prevented from moving along a lengthwise direction of the optical fiber and which cover part is not pierced.

US Pat. No. 10,191,224

OPTICAL RECEPTACLE

Toto Ltd., Fukuoka (JP)

1. An optical receptacle, comprising:a fiber stub including an optical fiber, a ferrule, a transparent member and an elastic member, the optical fiber including cladding and a core for conducting light, the ferrule having a through-hole fixing the optical fiber, the elastic member being disposed in the through-hole of the ferrule with the optical fiber; and
a holder holding the fiber stub,
wherein the through-hole of the ferrule includes a small diameter portion having the optical fiber disposed therein, a large diameter portion having a slit which has a constant width and which passes through a central axis of the ferrule, and the transparent member is disposed on a bottom surface of the slit.

US Pat. No. 10,191,222

OPTICAL CONNECTOR APPARATUS

JAPAN AVIATION ELECTRONIC...

1. An optical connector connectable with a connection member along a predetermined direction, the connection member comprising at least two grip portions each having conductivity, and the optical connector comprising a connector housing, a first ferrule having a first end surface, and a second ferrule having a second end surface, wherein:the connector housing arranges the first ferrule and the second ferrule along a direction perpendicular to the predetermined direction,
the first end surface and the second end surface face a same orientation as each other in the predetermined direction, and the first end surface and the second end surface do not face each other,
the first ferrule is provided with a first conductive portion,
when the optical connector is connected to the connection member, one of the grip portions grips the first conductive portion so as to be electrically connected with the first conductive portion,
the second ferrule is provided with a second conductive portion,
when the optical connector is connected to the connection member, the other one of the grip portions grips the second conductive portion so as to be electrically connected with the second conductive portion, and
in the predetermined direction, a distance between the first end surface and the first conductive portion is different from another distance between the second end surface and the second conductive portion.

US Pat. No. 10,191,218

OPTICAL ELEMENT AND OPTICAL CONNECTOR

Konica Minolta, Inc., To...

1. An optical element coupled to a ferrule that holds an optical fiber for single mode, the optical element comprising:a glass-made optical portion;
a plurality of lenses disposed in the optical portion; and
a resin-made holder that holds the optical portion, wherein
the lenses are disposed with respect to an end portion of the optical fiber, using at least a part of the holder, wherein
a shaft is inserted in the ferrule,
the optical portion has a notch,
and the optical element is coupled to the ferrule by engaging the shaft with the notch and the holder.

US Pat. No. 10,191,217

STRUCTURE FOR COUPLING A PHOTONIC CIRCUIT TO AN EXTERNAL DEVICE

1. A device comprising first and second photonic circuits, each one of the first and second photonic circuits comprising a structure of coupling to an outer device, the structure comprising:a main waveguide having a rectangular transverse cross-section; and
four secondary waveguides, each secondary waveguide having a first portion substantially parallel to the main guide arranged in the vicinity of the main guide to perform an evanescent wave coupling between the main guide and the secondary guide, the first portion extending in a second portion having an end opposite to the first portion defining a coupling surface of the secondary guide, emerging at the level of an external surface of the circuit, wherein the first portions of the four secondary guides are, in transverse cross-section, arranged around the main guide on the diagonals of the main guide, and
wherein the coupling surfaces of the four secondary guides of the first circuit are respectively placed against the coupling surfaces of the four secondary guides of the second circuit.

US Pat. No. 10,191,216

FIBER-TO-WAVEGUIDE OPTICAL INTERFACE DEVICE AND COMPONENTS FOR PHOTONIC SYSTEMS

Corning Optical Communica...

1. A coupling device for an optical interface device for a photonic integrated circuit (PIC) assembly, comprising:a body having a front end, a back end, an upper surface and a lower surface;
at least one alignment feature at the front end of the body; and
a tab abutting the front end of the body, the tab comprising a first downwardly depending tab section and a second downwardly depending tab section that extend below the body and that define a downward facing ledge,
wherein the tab has a U-shape and includes at least one hole aligned with the at least one alignment feature.

US Pat. No. 10,191,215

WAVEGUIDE FABRICATION METHOD

ECOLE POLYTECHNIQUE FEDER...

1. A waveguide fabrication method including the steps of:providing a substrate including a waveguide recess structure to receive a waveguide material for forming a waveguide and a stress release recess structure, the stress release recess structure arranged along both sides of a channel formed by the waveguide recess structure to enclose the waveguide recess structure; and
depositing the waveguide material onto the substrate and into the waveguide recess structure and the stress release recess structure.

US Pat. No. 10,191,214

PHOTONIC INTEGRATED CIRCUIT HAVING A RELATIVE POLARIZATION-ROTATING SPLITTER/COMBINER

NOKIA OF AMERICA CORPORAT...

1. An apparatus comprising a waveguide structure disposed on a planar substrate;wherein the waveguide structure comprises:
a first waveguide core disposed on the planar substrate;
a second waveguide core disposed on the planar substrate and separated by a gap from the first waveguide core; and
a slab core disposed on the planar substrate and having a first end and a second end, the first end being narrower than the second end;
wherein, within a first planar cross-section, the waveguide structure has a portion of the first waveguide core and a portion of the second waveguide core, said portions of the first and second waveguide cores not being directly attached to the slab core, the first planar cross-section being orthogonal to the planar substrate;
wherein, within a second planar cross-section, the slab core comprises a first portion located within the gap, the first portion being directly attached to the first waveguide core and being separated by the gap from the second waveguide core, the second planar cross-section being parallel to the first planar cross-section; and
wherein, within a third planar cross-section, the slab core comprises a second portion located within the gap, the second portion being directly attached to the first waveguide core and to the second waveguide core to bridge the gap, the third planar cross-section being parallel to the first planar cross-section.

US Pat. No. 10,191,211

DISPLAY APPARATUS AND METHOD OF MANUFACTURING THE DISPLAY APPARATUS

Sakai Display Products Co...

1. A display apparatus comprising:a display panel which displays an image on a front surface thereof;
a light guide plate disposed to face a back surface of the display panel;
a plurality of optical sheets interposed between the display panel and the light guide plate; and
a spacer which is sandwiched between the display panel and the light guide plate to secure a space for interposing the plurality of optical sheets therebetween,
wherein the spacer has
a space holding layer, which is formed by coating and solidifying a solidifiable liquid, and is fixed to the light guide plate and securing the space and
a fixed layer, which is formed by coating and solidifying a solidifiable liquid, and is sandwiched between the display panel and the space holding layer and fixed to the display panel,
wherein a thickness of the space holding layer is thicker than a total of thicknesses of one or more optical sheets, except for an optical sheet nearest to the display panel among the plurality of optical sheets, and
the fixed layer is made of a material adapted to start curing with a lapse of 1 to 5 minutes after irradiation with UV rays.

US Pat. No. 10,191,210

OPTICAL SHEET AND DISPLAY DEVICE HAVING THE SAME

LG DISPLAY CO., LTD., Se...

1. An optical sheet comprising:a plate-shaped optical sheet body having an active area and a non-active area; and
a plurality of fixing portions provided at corners of the optical sheet body in the non-active area,
wherein each fixing portion protrudes from the corresponding corner of the optical sheet body,
wherein each fixing portion is a unitary member that is provided without apertures,
wherein each fixing portion is provided in a respective buffer region of a guide panel,
wherein each buffer region has a predetermined depth that conforms to the shape of the respective fixing portion and has a shape that conforms to an outer surface of the respective fixing portion to fix the fixing portion thereto, and
wherein each buffer region is a gap that allows the guide panel to fluctuate in size.

US Pat. No. 10,191,209

LIGHT GUIDE PLATE, BACKLIGHT MODULE AND DISPLAY DEVICE

BOE TECHNOLOGY GROUP CO.,...

1. A light guide plate, comprising: a film limit portion, arranged on a light exiting surface of the light guide plate and formed as a protruding structure to limit an optical film arranged on the light exiting surface of the light guide plate; anda fixed part, continuously extending along a# the length of three side surfaces of the light guide plate and formed as a protruding structure to fix the light guide plate to a frame arranged on the side surfaces of the light guide plate,
wherein the fixed part includes an engagement step, arranged continuously along the length of three side surfaces of the light guide plate and has a height which is less than a thickness of the light guide plate, the engagement step is formed by extending a bottom surface of the light guide plate and the engagement step is protruded toward a frame with an engagement groove for engagement thereto,
wherein the film limit portion comprises at least one limit pillar, the at least one limit pillar is arranged in a region corresponding to the optical film of the light exiting surface of the light guide plate,
wherein the film limit portion further includes a bearing wall partially surrounding the optical film and being continuous, the bearing wall is arranged at an edge except the edge corresponding to the incident side of the light guide plate of the light exiting surface of the light guide plate.

US Pat. No. 10,191,205

BACKLIGHT SOURCE, BACKLIGHT UNIT, DISPLAY APPARATUS, AND FABRICATING METHOD THEREOF

BOE TECHNOLOGY GROUP CO.,...

1. A backlight unit, comprising:a light guide plate;
a light-bar;
a plurality of first light sources and a plurality of second light sources alternatively located on the light-bar in a staggered arrangement; and
a plurality of first serrations and a plurality of second serrations arranged on a light incident side of the light guide plate,
wherein:
the plurality of first light sources include a first phosphor that is able to realize a first color gamut range, and the plurality of second light sources include a second phosphor that is able to realize a second color gamut range,
each first serration includes a plurality of first dots having spherical surfaces, and each second serration includes a plurality of second dots having spherical surfaces,
a diameter of each first dot is less than a diameter of each second dot so that a reflecting surface of each second dot is greater than a reflecting surface of each first dot, and
in each first serration, a number of the first dots in a row decreases when a distance becomes larger from the first light source, and in each second serration, a number of the second dots in a row decreases when a distance becomes larger from the second light source so as to eliminate a hotspot phenomenon.

US Pat. No. 10,191,204

MATERIALS AND LIGHTGUIDES FOR COLOR FILTERING IN LIGHTING UNITS

GE Lighting Solutions, LL...

1. A lightguide of a lighting unit,at least a portion of the lightguide being formed of a composite material comprising a polymeric matrix material and an inorganic particulate material that contributes a color filtering effect to visible light passing through the composite material,
the inorganic particulate material comprising a neodymium compound containing Nd3+ ions, wherein the neodymium compound is an Nd—F compound or an Nd—X—F compound where X is at least one element chosen from the group consisting of elements that form compounds with neodymium and elements other than neodymium that form compounds with fluorine;
wherein the lightguide is configured to trap light received at an edge of the lightguide through total internal reflection, and redirect trapped light to be extracted from the lightguide at a surface thereof.

US Pat. No. 10,191,202

TOUCH PANEL ASSEMBLY HAVING LIGHT GUIDE PORTION AND PORTABLE ELECTRONIC DEVICE HAVING THE SAME

HTC Corporation, Taoyuan...

1. A touch panel assembly, comprising:a touch panel, comprising:
a plurality of sensing series; and
a plurality of pads, disposed at a plurality of bonding regions of the touch panel, and electrically connected to the corresponding sensing series respectively, wherein the bonding regions are located at a side of the touch panel;
a flexible circuit board, comprising:
a plurality of bonding portions, extended and connected to the bonding regions respectively, wherein each of the bonding portions comprises a plurality of terminals electrically connected to the corresponding pad; and
at least one light guide portion, comprising a connecting portion and an extending portion, wherein the connecting portion is connected to the corresponding bonding portion, and the extending portion is connected to the connecting portion and extended away from the sensing series of the touch panel;
a light guide film directly covering an entire top surface of the flexible circuit board;
at least one input element, located right above the extending portion; and
at least one light emitting element, disposed at a light incident side of the light guide portion and configured to emit a light beam, wherein the light beam enters the light guide portion and illuminates the input element.

US Pat. No. 10,191,200

QUANTUM ROD SHEET, BACKLIGHT UNIT, DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF

SAMSUNG DISPLAY CO., LTD....

1. A display device, comprising:a display panel:
an upper polarizing plate and a lower polarizing plate, which are disposed on opposing surfaces of the display panel, respectively; and
a backlight unit disposed under the display panel,
wherein the backlight unit comprises:
a light source which emits light; and
a quantum rod sheet which receives and polarizes the light provided from the light source,
wherein the quantum rod sheet comprises a plurality of quantum rods which are arranged in a predetermined direction and
wherein the quantum rods of the quantum rod sheet comprise at least two quantum rods having different sizes from each other.

US Pat. No. 10,191,197

BACKLIGHT MODULE AND DISPLAY DEVICE

BOE TECHNOLOGY GROUP CO.,...

1. A backlight module, comprising:a light-guiding plate;
a light bar arranged at a light incident side of the light-guiding plate; and
a light beam processing device arranged at an outside of the light-guiding plate to collect light beams not entered into the light-guiding plate, and configured to transmit the collected light beams to a light compensation position to emit the collected light beams into the light-guiding plate,
wherein the light beam processing device comprises a plurality of optical fibers, and each of the plurality of optical fibers comprises a light incident end, an optical fiber body and a light-exiting end.

US Pat. No. 10,191,194

SPECTRAL TARGET FOR MACROSCOPIC AND MICROSCOPIC REFLECTANCE IMAGING

Rochester Institute of Te...

1. A spectral target for determining the spectral reflectance factor and/or colorimetric coordinates of a sample, comprising:a mirror-like substrate containing a plurality of microstructures arranged in an array across the surface of the substrate and each one of the plurality of microstructures having an opaque multi-layer spectrally selective coating with a specific spectral reflectance profile, wherein the substrate has multiple spectral selectivity profiles in multiple locations.

US Pat. No. 10,191,193

NANO BI-MATERIAL ELECTROMAGNETIC SPECTRUM SHIFTER

Hong Kong Baptist Univers...

1. A tunable electromagnetic spectrum shifter comprising: at least two different nano particles deposited as at least one layer onto at least one surface of one or more transparent, translucent, or reflective substrates; wherein the at least two different nano particles are plasmonically coupled and electromagnetic spectrum shifting is achieved via plasmonic coupling between the at least two different nano particles in the at least one layer of at least two different nano particles; wherein the at least two different nano particles are within 1-15 nm of each other on the at least one surface of an one or more transparent, translucent, or reflective substrate; and wherein relative positions of the at least two different nano particles in each pair of the at least two different nano particles are in random three-dimensional direction in respect with other pairs such that the at least two different nano particles in each of said at least one layer of at least two different nano particles are not arranged as one layer of one nano particles stacked on top of another layer of the other one nano particles.

US Pat. No. 10,191,191

DIFFRACTIVE WAVEPLATE LENSES AND APPLICATIONS

Beam Engineering for Adva...

1. An optical system comprising: a light source; one or more diffractive waveplate lenses with switchable optical power, each diffractive waveplate lenses having a thin film of birefringent material, a substrate for deposition of the birefringent material having an optical axis orientation in each thin film of said birefringent material spatially modulated in one or both transverse directions parallel to the substrate on which said thin film of said birefringent material is applied; and switching devices for selectively switching the optical power of said diffractive waveplate lenses, wherein each of k successive diffractive waveplate lens has a focusing power double of the focusing power of the adjacent lens to focus the beam of said light source to any of 2k focal planes, adjacent accessible focal planes being equally separated, for circularly polarized light.

US Pat. No. 10,191,190

SYNTHETIC DIAMOND OPTICAL MIRRORS

ELEMENT SIX TECHNOLOGIES ...

1. A mirror for use in high power optical applications, the mirror comprising:a support plate comprising a synthetic diamond material; and
a reflective coating disposed over the support plate,
wherein the reflective coating comprises a bonding layer of carbide forming material selected from any of W, Cr, or Ti, which bonds the reflective coating to the synthetic diamond material in the support plate, a reflective metal layer disposed over the bonding layer, and one or more layers of dielectric material disposed over the reflective metal layer,
wherein the bonding layer and the reflective metal layer together have a total thickness in a range 50 nm to 10 ?m with the reflective metal layer having a thickness of no more than 5 ?m, and
wherein the support plate and the reflective coating are configured such that the mirror has a reflectivity of at least 99% at an operational wavelength of the mirror,
wherein the bonding layer and the reflective metal layer are formed of different materials, and
wherein the operational wavelength is one of 10.6 ?m, 1.06 ?m, 532 nm, 355 nm, or 266 nm.

US Pat. No. 10,191,189

OPTICAL LENS, OPTICAL LENS UNIT, AND IMAGING DEVICE

KONICA MINOLTA, INC., To...

1. An optical lens having a cylindrical shape, wherein, when an optical surface diameter of a first optical surface on an object side is defined as d1, the optical surface diameter of a second optical surface on an image side is defined as d2, and a lens diameter is defined as D, d1/d2<0.5 and also d2/D>0.9 are satisfied, the optical lens comprising:a lens frame receiving surface provided on a surrounding side of the first optical surface; and
an adhesion space formation lens portion disposed receding from the lens frame receiving surface to a side of the second optical surface, on the surrounding side of the lens frame receiving surface,
wherein the adhesion space formation lens portion is formed by a first step surface provided on the surrounding side of the lens frame receiving surface and a second step surface provided on the surrounding side of the first step surface, and the second step surface is not perpendicular to the first step surface.

US Pat. No. 10,191,188

ARRAY-BASED IMAGING RELAY

Microsoft Technology Lice...

1. A lens system comprising:a first lens array assembly comprising a first plurality of cells, each cell of the first plurality of cells configured to exhibit a pair of Fourier transform lenses that implement a phase-corrected Fourier transform; and
a second lens array assembly comprising a second plurality of cells, each cell of the second plurality of cells configured to exhibit a pair of Fourier transform lenses that implement a phase-corrected Fourier transform;
wherein the first and second lens array assemblies are positioned relative to one another along an optical axis of the lens system such that an image of an object is provided at an image conjugate distance from the second lens array assembly, and
wherein a distance between the first and second lens array assemblies is dependent on an object conjugate distance of the object, the image conjugate distance, focal lengths of the Fourier transform lenses of the first and second pluralities of cells, and respective pitches of the first and second pluralities of cells.

US Pat. No. 10,191,185

LIGHT-EMITTING APPARATUS

LG INNOTEK CO., LTD., Se...

1. A light-emitting apparatus comprising:at least one light source;
a wavelength converter configured to convert a wavelength of light emitted from the light source;
a first lens configured to face a light emission surface of the wavelength converter;
a rounded reflector spaced apart from the first lens, the reflector being configured to reflect light emitted from the first lens; and
a base substrate configured to support the reflector, the wavelength converter and the first lens being disposed on the base substrate.

US Pat. No. 10,191,183

METHOD OF CONSTRUCTING DIGITAL TERRAIN MODEL

R.O.G. s.r.o., Prague (C...

1. A method of measurement, processing and use of a digital terrain model (“DTM”) for objective evaluation of geometric parameters of surfaces of a measured object, including roads and other surfaces, by which the DTM is obtained with a same elevation accuracy in relation to a vertical coordinate system at any place of the measured object, wherein measurements are performed by a measuring device comprising a set of three vehicles (290, 291, 292) arranged in a row, said set of three vehicles comprising an end vehicle (292), a middle vehicle (290) and a front vehicle (291), said measuring device further comprising instruments including—a laser scanner (210), a first Global Navigation Satellite System (GNSS) receiver (221) and a levelling device for elevation determination (231), all arranged on the middle vehicle (290);
a target device (232) arranged on each of the end vehicle (292) and the front vehicle (291), and configured to be used in combination with the levelling device (231) for elevation determination;
a second GNSS receiver (222) arranged on the front vehicle (291);
wherein the measurements are performed in n successive measurement cycles by the instruments of the measuring device, which are at standstill during each measurement, and which are moved as a whole between individual measurement cycles; where n measurement cycles create one measurement stage; wherein n is a number of measurement cycles;
wherein the method comprises the following steps:
during each measurement cycle:
performing a position measurement of the laser scanner (210) using the first GNSS receiver (221);
performing a surface measurement of the measured object with the laser scanner (210) at a scan-position so as to obtain a point cloud in a coordinate system of the laser scanner;
performing a stabilization of a front point located at the front vehicle (291) on the surface of the measured object;
surveying a position of the front point at least by the second GNSS (222) receiver; and
performing at least one backsight elevation measurement of the target device (232) on the end vehicle (292), which is located at an end point, and at least one foresight elevation measurement of the target device (232) on the front vehicle (291), which is located at the front point, using the levelling device for elevation sighting (231) on the middle vehicle (290), so as to measure elevations of the front and end points;
after measurements of a measurement cycle are completed, or during such measurements, saving data about the position, of the laser scanner (210), point cloud data, and data about the elevations of the front and end points in a computer (240);
after each measurement cycle, moving the measuring device as a whole, so that,
the middle vehicle (290) is moved to a new scan-position for another surface measurement of the measured object using the laser scanner (210);
the end vehicle (292) is moved to a new backsight position, which is the front point (252), which was occupied by the front vehicle (291) in the previous measurement cycle; and
the front vehicle (291) is moved to a new foresight position where, during a next measurement cycle, stabilisation and measurements of a new front point will be performed using the levelling device (231) on the middle vehicle, and the target device (232) and second GNSS receiver (222) on the front vehicle;
wherein when one measurement stage is completed, the method includes the following additional steps:
transforming the spatial coordinates of points of the point clouds obtained via the laser scanner (210) into a global coordinate system using the measured position of the laser scanner (210) at each individual scan-position of the laser scanner (210) and a point cloud correlation algorithm between individual point clouds of the measurement stage, by which a final position, a final orientation, and an approximate inclination of the point cloud of each individual scan-position of the laser scanner (210) is obtained,
making the point clouds more accurate by performing a transformation of the data about the front and end points in terms of elevation and inclination;
further processing the obtained and more accurate data into a digital model of a real topographic surface of the measured object, wherein the digital model represents surface points on the measured object with the elevation accuracy of the surface in a given time of the measurement of one stage.

US Pat. No. 10,191,182

ACCURACY OF WATER BREAK-THROUGH TIME PREDICTION

Saudi Arabian Oil Company...

1. A method for correcting relative permeability data used in a reservoir simulation, comprising:obtaining, by a hardware data processing apparatus, a plurality of initial relative permeability data, wherein the plurality of initial relative permeability data comprise a plurality of initial water relative permeability values and a plurality of initial oil relative permeability values, each of the plurality of initial water relative permeability values corresponding to an initial oil relative permeability value and an initial water saturation level;
determining, by the hardware data processing apparatus, viscosity data;
determining, by the hardware data processing apparatus, a flood-front saturation point based on the viscosity data and the initial relative permeability data;
generating, by the hardware data processing apparatus, a plurality of corrected relative permeability data based on the plurality of initial relative permeability data and the flood-front saturation point, wherein the generating the plurality of corrected relative permeability data comprises:
for each of the plurality of initial relative permeability data:
comparing the initial water relative permeability value of the initial relative permeability data with the flood-front saturation point;
if the initial water relative permeability value is smaller than the flood-front saturation point, setting a corresponding corrected water relative permeability value to zero; and
if the initial water relative permeability value is greater than or equal to the flood-front saturation point, setting the corresponding corrected water relative permeability value to the initial water relative permeability value; and
simulating water break-through time using the plurality of the corrected relative permeability data.

US Pat. No. 10,191,181

MULTI-CHANNEL SYSTEM FOR TRUCK AND CARGO SCANNING USING IMPULSE RADIATION SOURCES

Adani Systems Inc., Alex...

1. A multi-channel system for truck scanning, comprising:an impulse radiation source;
a plurality of detection circuits, each detection circuit comprising a scintillator, a photodiode, a supplemental circuit, an integrator and an Analog to Digital Converter (ADC), connected in series,
wherein a current of the photodiode is proportional to impulse gamma radiation from the impulse radiation source;
a data storage device storing outputs of the ADCs and providing the stored outputs to a computer that converts the outputs to a shadow image of the scanned truck,
wherein the supplemental circuit isolates a capacitance of the photodiode from the integrator, filters out low frequency signals from the photodiode, amplifies the signal from the photodiode and reduces a bandwidth of the photodiode seen by the integrator, and
wherein the supplemental circuit includes a low noise amplifier to reduce an influence of capacitance of the photodiode on system noise.

US Pat. No. 10,191,180

LARGE SCALE GAS ELECTRON MULTIPLIER AND DETECTION METHOD

Lingacom Ltd., Tel Aviv ...

1. A detector assembly comprising:an insulating substrate having a planar surface;
a printed circuit board (PCB) mounted on the planar surface of the insulating substrate, the PCB having opposing first and second surfaces, the first surface exposed to the insulating substrate, the second surface including printed circuit lines;
a resistive plate disposed on and in direct physical contact with the second face of the PCB;
a drilled board disposed on the resistive plate;
a cathode disposed above the drilled board, the cathode defining a drift volume between the cathode and the drilled board, the drilled board disposed between the drift volume and the resistive plate;
a mechanical assembly connected to the insulating substrate and the resistive plate, wherein the mechanical assembly applies a force between the insulating substrate and the resistive plate to form an electrical contact between the printed circuit lines on the PCB and the resistive plate;
wherein the drilled board includes a plurality of holes, the holes extending through the drilled board to expose portions of the resistive plate; and
wherein a pitch between adjacent holes is about 2 mm to about 5 mm.

US Pat. No. 10,191,179

MEASURING CURRENT FROM AN ELECTRODE USING A NON-LINEAR ELEMENT

SCHLUMBERGER TECHNOLOGY C...

1. An arrangement for drilling a wellbore, the arrangement comprising:a drill bit comprising a plurality of cutting elements deployed in a bit body; the drill bit connected to a length of drill string;
a transmitter toroid deployed on the length of drill string and configured to transmit an AC voltage at a first frequency;
a receiver toroid deployed on the length of drill string and configured to receive an alternating current at a harmonic of the first frequency; and
at least one electrode deployed in the bit body, the at least one electrode being electrically insulated from the bit body and being electrically connected to the length of drill string through a non-linear circuit element such that alternating current emanating from the at least one electrode is at the harmonic of the first frequency when the transmitter toroid transmits at the first frequency.

US Pat. No. 10,191,178

THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE LOGGING INSTRUMENT PROBE, LOGGING INSTRUMENT AND ANTENNA EXCITATION METHOD

CHINA UNIVERSITY OF PETRO...

1. A three-dimensional nuclear magnetic resonance logging instrument probe, comprising: a probe framework, four magnets and eight independently fed antennas; whereinthe four magnets are uniformly distributed along a circumference of the probe framework, the magnets are magnetized in a radial direction of the probe framework, wherein, two magnets placed opposite to each other are magnetized from outside to inside, and the other two magnets placed opposite to each other are magnetized from inside to outside;
in the probe framework, each of the magnets is provided with two antennas;
the two antennas corresponding to each of the magnets comprise a left antenna provided on one side of the corresponding magnet and a right antenna provided on the other side of the corresponding magnet;
the left antenna and the right antenna corresponding to each of the four magnets are electrically connected;
the probe framework is provided with four receiving chambers matched with the four magnets, and the four magnets are fixed within the four receiving chambers;
the probe framework is arranged with eight grooves, the eight antennas are arranged in the eight grooves and the eight grooves are filled with high magnetic permeable materials.

US Pat. No. 10,191,175

METHOD AND SYSTEM FOR MAPPING A GEOLOGICAL STRUCTURE OF A FORMATION ON ONE SIDE OF A SURFACE USING MAGNETIC MOMENTS OF DIFFERENT VALUES

Skytem Survey APS, Aarhu...

1. A method for mapping geological structures of a formation on a side of a surface, comprising:generating a magnetic moment using at least one magnetic moment generator to build up a magnetic field in the formation in an on-period, wherein the magnetic moment is positioned on another side of the surface;
changing the magnetic moment to change the magnetic field; and
making at least one record in a recording device at a recording time trecord in an off-period, wherein the record includes at least a representation of the change in the magnetic field and/or a representation of the magnetic field obtained by a B/E-measuring unit;
wherein the on-period is separated from the off-period by the act of changing the magnetic moment;
wherein the acts of generating, changing, and making are performed to execute a first sequence;
wherein the method further comprises repeating one or more of the acts of generating, changing, and making to execute a second sequence, each of the first and second sequences lasting a sequence period and comprising at least one moment period;
wherein in each of the first and second sequences, a plurality of magnetic moments are generated;
wherein the first and second sequences are executed at a same position or at positions that are separated by a maximum distance of 50 m;
wherein the at least one magnetic moment generator is configured to be carried by an airborne vehicle;
wherein the second sequence is consecutive to the first sequence, and wherein the first and second sequences are consecutively repeated; and
wherein each magnetic moment in the repeated consecutive first and second sequences has at least one adjacent magnetic moment having a different maximum absolute magnetic moment.

US Pat. No. 10,191,174

SYSTEM AND METHOD FOR DEEP DETECTION OF PETROLEUM AND HYDROCARBON DEPOSITS

LONGBRANCH ENTERPRISES IN...

1. A method for deep detection of petroleum and hydrocarbon deposits comprising:inserting one or more elongated electrodes into the ground at a testing site to generate a sensing array;
inserting a portion of a collapsible charge probe into the ground at the testing site, the collapsible charge probe including:
an elongated probe body having a probe top and bottom end and configured to be disassembled into a plurality of pieces, the top end extending from the ground and the bottom end disposed within the ground;
a first and second handle extending from the probe body at the probe body top end;
a trigger assembly at the probe body top end and disposed above the ground;
a removable charge tip disposed at the probe body bottom end holding an explosive charge cartridge, the charge tip disposed within the ground; and
an elongated firing shaft disposed within the probe body having a shaft top and bottom end and having a firing pin disposed at the shaft bottom end, the firing shaft being biased toward the shaft bottom end and configured to discharge the explosive charge cartridge held in the charge tip by actuation of the trigger assembly, the firing shaft further being configured to be disassembled into a plurality of pieces;
discharging, via the firing pin, the explosive charge cartridge held in the charge tip to generate a percussive seismic event proximate to the sensing array at a below-ground percussive seismic event location, the discharging being triggered by actuating the trigger assembly; and
recording sensing signals received by the sensing array, the sensing signals emitted from one or more sources in response to the percussive seismic event.

US Pat. No. 10,191,172

SYSTEM AND METHOD FOR OPERATING A SUBSEA SENSOR FIELD

OCTIO AS, Bergen (NO)

1. A method for autonomously operating a subsea sensor field monitoring a region of interest, comprising the steps of:deploying a system comprising:
an automated underwater vehicle (AUV);
a sub sea service station; and
a sensor field comprising a plurality of sensors configured for monitoring a region of interest, wherein at least one sensor in the sensor field comprises a permanently installed base unit and a removable control unit, the AUV comprises a first transport connector and the removable control unit comprises a second transport connector, and the service station comprises a docking connector configured for receiving the control unit;
monitoring the region of interest with the sensor field;
using the AUV to connect the removable control unit to the permanently installed base unit,
using the AUV to disconnect the first transport connector from the second transport connector;
operating the removable control unit at the permanently installed base unit for a predetermined period of time;
using the AUV to connect the first transport connector to the second transport connector;
using the AUV to remove the removable control unit from the permanently installed base unit;
using the AUV to move the removable control unit to the service station;
disconnecting the first transport connector from the second transport connector; and
connecting the removable control unit to the docking connector.

US Pat. No. 10,191,170

SEISMIC DATA ACQUISITION USING WATER VEHICLES

WESTERNGECO L.L.C., Hous...

1. A seismic acquisition system, comprising:at least one unmanned water vehicle;
at least one seismic streamer having a first end and a second end, wherein the first end is coupled to the at least one unmanned water vehicle, and wherein the at least one seismic streamer has one or more seismic sensors coupled thereto for recording data in a survey area; and
a buoyancy compensation mechanism coupled proximate to an end of the at least one seismic streamer, wherein the second end of the at least one seismic streamer is not attached to a secondary vessel, and wherein:
the buoyancy compensation mechanism is configured to change an orientation of the at least one seismic streamer between a substantially vertical direction and a substantially horizontal direction through a water column;
the buoyancy compensation mechanism is configured to orient the at least one seismic streamer towards the substantially vertical direction using at least the weight of the buoyancy compensation mechanism as a ballast; and
the first end of the at least one seismic streamer is disposed closer to a water surface than the second end of the at least one seismic streamer is oriented in the substantially vertical direction.

US Pat. No. 10,191,165

USING AN OFFSET VECTOR TILE GATHER TO IMAGE A SUBSURFACE

CGG SERVICES SAS, Massy ...

1. A method for using an offset vector tile gather to image a subsurface, the method comprising:recording seismic data carrying structural information about the subsurface;
defining an offset vector tile gather by selecting a plurality of seismic traces from the recorded seismic data, each seismic trace in an offset vector tile comprising reflections from a plurality of subsurface reflectors such that the offset vector tile gather comprises a plurality of reflection points at given depths below a surface of the subsurface, each reflection point in the plurality of reflection points being disposed in a given seismic trace in the plurality of seismic traces where each given seismic trace extends from a seismic source located in one of a plurality of seismic source lines to a seismic receiver located in one of a plurality of seismic receiver lines, the plurality of reflection points defining an offset vector tile comprising a source line span parallel to the plurality of seismic source lines and a receiver line span parallel to the plurality of seismic receiver lines, the source line span being equal to or greater than a distance between adjacent seismic receiver lines in the plurality of seismic receiver lines and the receiver line span being less than a distance between adjacent seismic source lines in the plurality of seismic source lines; and
using the offset vector tile gather to produce a three dimensional image of the subsurface that has suppressed artifacts associated with footprint of seismic cables or nodes.

US Pat. No. 10,191,155

OPTICAL RESOLUTION IN FRONT OF A VEHICLE

LUMINAR TECHNOLOGIES, INC...

1. A lidar system comprising:a light source configured to emit light pulses;
a scanner configured to scan a field of view of the light source across a field of regard of the lidar system, including direct the light pulses at different angles relative to a forward-facing direction toward different points within the field of regard; and
a receiver configured to detect light from some of the light pulses scattered by one or more remote targets to identify a return light pulse, the receiver including:
a lens having a lens plane, wherein the lens is configured to focus the return light pulse; and
a plurality of photodetectors arranged on a detector plane behind the lens, wherein the detector plane is nonparallel to the lens plane to generate a wedge shaped depth of field.

US Pat. No. 10,191,153

AUGMENTED REALITY SONAR IMAGERY SYSTEMS AND METHODS

FLIR Systems, Inc., Wils...

1. A system comprising:a portable imaging device comprising a display and an imager position and/or orientation sensor (IPOS);
a sonar transducer assembly adapted to be mounted to a mobile structure and placed in a body of water; and
a logic device in communication with the sonar transducer assembly and the portable imaging device, wherein the logic device is configured to:
determine a waterline of the body of water relative to a field of view (FOV) of the display; and
render sonar data in a portion of the FOV that extends below the waterline.

US Pat. No. 10,191,151

SYSTEM AND METHOD FOR MONITORING VESSEL TRAFFIC INFORMATION

ELECTRONICS AND TELECOMMU...

1. A system for monitoring vessel traffic information, the system comprising at least one processor configured to implement:an interlock device configured to adjust identification information of a wireless terminal included in a received message to correspond to an identification system of an auto identification system (AIS) message and convert the received message into an AIS message type, when receiving a message including ship information from a wireless terminal of a ship located in at least one ship network;
a merging device configured to merge the ship information included in the converted AIS message with radar image information; and
a monitoring device configured to display merged monitoring information on a monitoring screen.

US Pat. No. 10,191,144

RADAR MOUNTING ESTIMATION WITH UNSTRUCTURED DATA

Waymo LLC, Mountain View...

1. A method comprising:for each of a plurality of radar units:
causing the transmission of at least two radar signals by the respective radar unit, wherein a first signal is transmitted from a first respective location and a second signal is transmitted from a second respective location, and
receiving a respective reflection signal by the respective radar unit, wherein the respective reflection signal is associated with each of the transmitted signals;
determining, by a processor, at least one stationary object that caused reflection in the plurality of reflection signals;
based on the determined stationary object, determining, by the processor, an offset for the radar unit, wherein the offset comprises at least one of an elevational offset, a rotational offset, and an azimuthal offset; and
operating the radar unit using the determined offset to determine a position of an object causing radar reflections.

US Pat. No. 10,191,141

LIGHT BEAM PAINTED FLUORESCENT RADAR IMAGE DISPLAY SCREEN

1. A display system comprising:a fluorescent screen, a plurality of rotating structures, and a radiation source;
wherein the display screen is adapted for use with a radar system;
wherein the radiation source stimulates the fluorescent screen;
wherein the track of radiation generated by the radiation source is directed by the plurality of rotating structures;
wherein the radiation generated by the radiation source is directed to a target location on the fluorescent screen by the plurality of rotating structures;
wherein the target location on the fluorescent screen is received from the radar system the display system is adapted to work with.

US Pat. No. 10,191,140

LUMINAIRE IDENTIFICATION AND POSITIONING BY CONSTELLATION

OSRAM SYLVANIA Inc., Wil...

1. A method for determining the position of a computing device, the method comprising:obtaining, by the computing device, an image of a subset of luminaries from a plurality of luminaires located in an indoor environment, wherein each subset grouping of luminaires in the plurality of luminaires is uniquely identifiable;
comparing the subset of luminaires to a database storing each uniquely identifiable subset grouping of luminaires in the plurality of luminaires, wherein the database includes position information for each luminaire in the plurality of luminaires; and
determining the position of the computing device based on the comparison of the subset of luminaires to the database.

US Pat. No. 10,191,139

SYSTEM AND METHOD FOR OBJECT TRACKING ANTI-JITTER FILTERING

ISOLYNX, LLC, Haverhill,...

1. An object tracking anti-jitter filtering method, the method comprising:periodically receiving, within an object tracking system, a raw location point for a tracking tag attached to a tracked object;
averaging raw location points corresponding to an averaging window to periodically generate an averaged location point; and
determining physical movement of the tracked object based upon three most recently determined average location points corresponding to the object; and
adjusting a most recent of the three average location points such that the determined physical movement of the tracked object does not exceed predefined physical limits of the tracked object.

US Pat. No. 10,191,137

SYSTEMS AND METHODS FOR BEACON DEVICE FLEET MANAGEMENT

Google LLC, Mountain Vie...

1. A computer-implemented method to enable beacon device fleet management, the method comprising:receiving, by a fleet management system, a plurality of observation reports respectively from a plurality of mobile computing devices, each observation report identifying at least one of a plurality of beacon devices observed by a reporting mobile computing device and describing at least a time at which the reporting mobile computing device observed the identified at least one beacon device;
analyzing, by the fleet management system, at least a portion of the plurality of observation reports that are associated with a first beacon device to determine a detection interval for the first beacon device, the detection interval comprising an amount of time that is based at least in part on a historical observation frequency at which the first beacon device has been observed by the mobile computing devices;
comparing, by the fleet management system, the detection interval of the first beacon device to a difference between a current time and a timestamp of a most recent observation report associated with the first beacon device; and
determining, by the fleet management system, a detection status of the first beacon device based at least in part on the comparison of the detection interval of the first beacon device to the difference between the current time and the timestamp of the most recent observation report associated with the first beacon device, wherein the detection status is indicative of a current operation status of the first beacon device.

US Pat. No. 10,191,136

DETERMINING MISS DISTANCE AND BULLET SPEED OF A BURST OF BULLETS

BAE Systems Information a...

1. A method for determining miss distance and bullet speed of a burst of bullets, the method comprising:estimating shock wave (SW) vectors emanating from bullets using a first sensor;
estimating firing point (FP) vectors and closest-point-of-approach (CPA) vectors emanating from the bullets using a second sensor, wherein the first sensor and the second sensor are located on a single platform;
determining that the SW vectors, the FP vectors and the CPA vectors are emanating from the burst of bullets; and
determining the miss distance and bullet speed of the burst of bullets using the FP vectors, the SW vectors, and the CPA vectors that are emanating from the burst of bullets.

US Pat. No. 10,191,135

WIRELESS NETWORK-BASED POSITIONING METHOD AND POSITIONING APPARATUS

HUAWEI TECHNOLOGIES CO., ...

1. A wireless network-based positioning method, comprising:obtaining time information used for determining a current location of a to-be-positioned node, wherein the time information records times of arrival of a first sounding signal at at least three anchor nodes, and the first sounding signal is sent by the to-be-positioned node at the current location;
determining time differences of arrival of the first sounding signal at the at least three anchor nodes according to recorded historical information and the time information, wherein the time differences of arrival of the first sounding signal at the at least three anchor nodes are differences between the times of arrival of the first sounding signal at the at least three anchor nodes, the historical information records locations of the at least three anchor nodes, a historical location at which the to-be-positioned node sends a second sounding signal, and times of arrival of the second sounding signal at the at least three anchor nodes, and the second sounding signal is a sounding signal that is used for positioning and that is sent by the to-be-positioned node before the to-be-positioned node sends the first sounding signal; and
determining the current location of the to-be-positioned node according to the locations of the at least three anchor nodes and the time differences of arrival of the first sounding signal at the at least three anchor nodes,wherein the determining the current location of the to-be-positioned node according to the locations of the at least three anchor nodes and the time differences of arrival of the first sounding signal at the at least three anchor nodes comprises:determining the current location of the to-be-positioned node according to formulas
wherein (xA, yA), (xB, yB), and (xC, yC) respectively represent locations of a first anchor node, a second anchor node, and a third anchor node in the at least three anchor nodes, TAB represents a time difference of arrival of the first sounding signal at the first anchor node and the second anchor node, TBC represents a time difference of arrival of the first sounding signal at the second anchor node and the third anchor node, (x, y) represents the current location of the to-be-positioned node, and c represents the propagation velocity of the sounding signal sent by the to-be-positioned node.

US Pat. No. 10,191,134

METHOD AND APPARATUS FOR DYNAMIC DISTORTION CORRECTION OF MAGNETIC RESONANCE IMAGE RECORDINGS

Siemens Aktiengesellschaf...

1. A method for correcting dynamically acquired magnetic resonance (MR) image data, comprising:in a computer generating control signals and providing said control signals from said computer to an MR scanner comprising a basic (B0) field magnet that generates a B0 field, in order to operate the MR scanner so as to obtain a B0 field map as a basic reference field map;
in said computer, generating further control signals and providing said further control signals from said computer to said MR scanner, after obtaining said basic reference field map, in order to operate the MR scanner so as to acquire MR data, during a predetermined MR data acquisition time, from a subject situated in the MR scanner, said MR data having distorted coordinates due to said B0 field changing during said predetermined MR data acquisition time;
in said computer, using the acquired MR data to dynamically a set of distorted B0 field maps during said MR data acquisition time;
in said computer, during said predetermined MR data acquisition time, comparing each of the distorted, dynamically obtained B0 field maps to said basic reference field map dependent on a comparison criterion, and identifying any distorted, dynamically obtained B0 field map that does not satisfy said comparison criterion as an incorrect B0 field map;
in said processor, correcting each incorrect B0 field map, to obtain a set of corrected distorted, dynamically obtained B0 field maps; and
correcting said MR data acquired from said subject in said processor using said set of corrected distorted, dynamically obtained B0 field maps, and using the corrected MR data from the subject to reconstruct image data that are free of artifacts to said distorted coordinates, and display said image data at a display screen as in MR image of the subject.

US Pat. No. 10,191,126

SYSTEMS AND METHODS FOR SPATIAL GRADIENT-BASED ELECTRICAL PROPERTY PROPERTIES TOMOGRAPHY USING MAGNETIC RESONANCE IMAGING

Regents of the University...

1. A method for measuring electrical properties of a tissue using a magnetic resonance imaging (MRI) system, the steps of the method comprising:a) directing the MRI system to acquire B1+ map data for each channel in a multichannel transmitter while a subject is present in the MRI system;
b) directing the MRI system to acquire a B1? map data for each channel in a multichannel receiver while the subject is present in the MRI system;
c) generating from the acquired B1+ map data, B1+ field magnitude map and a B1+ relative phase map for each channel in the multichannel transmitter;
d) generating from the acquired B1? map data, a B1? field magnitude map and a B1? relative phase map for each channel in the multichannel receiver;
e) estimating a spatial gradient value that is based on a spatial gradient of electrical properties of the tissue, the spatial gradient value being estimated from the derived B1+ field magnitude maps, B1+ relative phase maps, B1? field magnitude maps, and B1? relative phase maps;
f) estimating electrical property values in the subject by spatially integrating the estimated spatial gradient values; and
g) generating a report comprising an image that depicts a spatial distribution of the computed electrical property values in the subject.

US Pat. No. 10,191,125

SENSOR UNIT HAVING MAGNETIC SENSORS RESPECTIVELY INCLUDING PRIMARY AND SECONDARY OUTPUT TERMINALS, AND MAGNETIC COLLECTOR MODULE INCLUDING THE SAME

DENSO CORPORATION, Kariy...

1. A sensor unit comprising:a plurality of magnetic sensors, each of which includes:
a magnetic sensing element, which senses a magnetic field;
an encapsulating portion, which encapsulates the magnetic sensing element;
a primary terminal group, which includes a plurality of terminals that project from a primary terminal forming part of the encapsulating portion, wherein the primary terminal forming part is one side of the encapsulating portion; and
a secondary terminal group, which includes a plurality of terminals that project from a secondary terminal forming part of the encapsulating portion, wherein the secondary terminal forming part is an opposite side of the encapsulating portion, which is opposite from the primary terminal forming part of the encapsulating portion about a center line centered between the primary terminal forming part and the secondary terminal forming part; and
a circuit board that has a common surface, to which the plurality of magnetic sensors is mounted, wherein:
among the plurality of magnetic sensors, two adjacent magnetic sensors, which are oriented in a common direction and arranged side by side such that the two adjacent magnetic sensors are placed one after another in a perpendicular direction, which is perpendicular to the center line of each of the two adjacent magnetic sensors and is parallel to a plane of the common surface of the circuit board, and the secondary terminal group of one of the two adjacent magnetic sensors is directly opposed to the primary terminal group of another one of the two adjacent magnetic sensors in the perpendicular direction;
the plurality of terminals of the primary terminal group of each of the plurality of magnetic sensors includes a primary output terminal configured to output an output signal generated based on a measurement value of the magnetic sensing element of the respective magnetic sensor;
the plurality of terminals of the secondary terminal group of each of the plurality of magnetic sensors includes a secondary output terminal configured to output the output signal such that both the primary and secondary output terminals output the output signal of that respective magnetic sensor; and
the primary output terminal and the secondary output terminal are placed asymmetrically to each other with respect to the center line centered between the primary terminal forming part and the secondary terminal forming part in each of the plurality of magnetic sensors.

US Pat. No. 10,191,113

APPARATUS HAVING SIMULATION UNIT FOR PRODUCING SIMULATION SIGNAL FOR TESTING AN ELECTRICAL COMPONENT

dSPACE digital signal pro...

1. An apparatus for testing an electrical component, the apparatus comprising:a simulation unit for producing a simulation signal that is transmitted to the electrical component under testing, the simulation unit connecting an electrical connecting device to the electrical component;
a plurality of test units providing sensor and actuator signals to the simulation unit,
wherein at least one of the plurality of test units are connected via the electrical connecting device to the simulation unit, the plurality of test units and the simulation unit being connected directly to the electrical connecting device,
wherein the electrical connecting device has at least one electrical switch device, which is arranged to make or break an electrical connection between at least one of the plurality of test units and the connecting device,
wherein the electrical component is separate from the apparatus,
wherein the electrical connecting device is one of a plurality of electrical connecting devices, which differ from one another with regard to at least one electrical property, and
wherein the apparatus further comprises:
a selecting device for selecting an electrical connection of the simulation unit and the plurality of test units to one of the electrical connecting devices, the plurality of electrical connecting devices each have at least one electric switch device, the electrical switch devices being arranged so that they make or break an electrical connection between the plurality of test units via the corresponding electrical connecting device.

US Pat. No. 10,191,110

APPARATUS AND METHOD FOR SELF-TESTING AN INTEGRATED CIRCUIT

NXP USA, INC., Austin, T...

1. A method of testing comprising:generating a reference voltage at an output of a reference circuit;
initiating a test of the reference circuit during a test mode;
determining whether the test of the reference circuit passes by performing a stuck-at test with a test voltage source by applying a test voltage from the test voltage source to a voltage comparator and determining that the voltage comparator trips between low and high output voltages in response to predetermined input voltages; and
after performing the stuck-at test with the test voltage source, comparing at the voltage comparator, if the test of the reference circuit passes, a first voltage with the reference voltage of the reference circuit to determine that the first voltage meets a predetermined criterion.

US Pat. No. 10,191,103

METHOD OF LOCATING A SOURCE OF TRANSIENT SIGNALS IN A DISPERSIVE ENVIRONMENT

INSTITUT POLYTECHIQUE DE ...

1. A method of locating in a dispersive environment a source of pulses with at least a pair of sensors, the method comprising the steps of:positioning a pair of sensors in the dispersive environment, the pair of sensors being located at a predetermined distance L to each other;
detecting a pulse at the level of each sensor originating from the source;
constructing a phase diagram for each of said pulses from N vectors having their coordinates corresponding to the amplitude of the pulse at a sampling time ti and at next successive sampling times; and
calculating the ratio for each pair of sensors between distances L1 and L2 from each sensor to the source with formula:
whereare the norms of vectorsof the phase diagrams corresponding to the pulses detected by the sensors so that the source is located by the phase diagrams without synchronization of the sensors;wherein the calculated location of the source is communicated to specify the location of a maintenance operation.

US Pat. No. 10,191,101

SYSTEM AND METHOD FOR DETECTING GROUND FAULT IN A DC SYSTEM

GENERAL ELECTRIC COMPANY,...

1. A ground fault detection system for locating a ground fault in a direct current (DC) power transfer system comprising:a ground fault detection component comprising:
a first switch and a second switch;
a first resistive element and a second resistive element;
wherein, the first switch is electrically coupled to the first resistive element and the second switch is electrically coupled to the second resistive element in a series configuration respectively,
a current sensor operatively coupled to a load and configured to measure a fault current at the load upon switching at least one of the first switch or the second switch to a conducting state; and
a DC grounding component coupled to the ground fault detection component in a parallel configuration between a positive rail and a negative rail of a first DC bus, wherein the DC grounding component is configured to provide a balanced ground reference voltage at a neutral point;
wherein the DC grounding component comprises a third resistive element and a fourth resistive element, a first capacitive element and a second capacitive element, or a combination thereof for providing the balanced ground reference voltage.

US Pat. No. 10,191,099

SEMICONDUCTOR TEST DEVICE AND METHOD, AND DATA ANALYSIS DEVICE

SAMSUNG ELECTRONICS CO., ...

1. A semiconductor test device, comprising:an actuator holding a radiation source and adjusting a distance between the radiation source and a sample; and
a controller controlling an operation of the actuator and calculating a soft error rate (SER) of the sample based on the distance between the radiation source and the sample,
wherein the controller calculates a first distance between the radiation source and the sample at which the SER of the sample becomes zero, and calculates a metal-to-dielectric ratio of the sample based on the first distance.

US Pat. No. 10,191,096

ELECTRIC VEHICLE DISAGGREGATION AND DETECTION IN WHOLE-HOUSE CONSUMPTION SIGNALS

Bidgely Inc., Mountain V...

1. A method of electronically detecting and disaggregating a consumption signal associated with the charging of an electric vehicle from a whole-house profile, comprising:identifying by an electronic processor potential interval candidates of electric vehicle charging, based at least in part upon long and decreasing patterns;
determining by the electronic processor intervals associated with the charging of an electric vehicle, based at least in part on evaluating each potential interval candidate;
determining by the electronic processor an initial point of charging for each interval associated with the charging of an electric vehicle; and
identifying that energy consumption associated with the charging of the electric vehicle occurred, and informing a user of the same.

US Pat. No. 10,191,095

WIRELESS SENSOR NETWORK FOR MEASUREMENT OF ELECTRICAL ENERGY CONSUMPTION

SOCOVAR S.E.C., Montreal...

1. A system for measuring electricity consumption of an environment having a plurality of electrical appliances, the system comprising:a plurality of measuring devices for connection to a wire between one of the plurality of electrical appliances and one of a plurality of corresponding circuit breakers, each one of the measuring devices comprising:
a Hall effect sensor configured to measure a current flowing through the wire; and
a sensor support for receiving the Hall effect sensor, the sensor support comprising an attachment member configured for attaching the sensor support to the wire outside of the circuit breaker such that the wire runs through the attachment member, and the sensor support having a sensor positioning guide for fixing a position of the Hall effect sensor with respect to the wire to a known and fixed relative position;
at least one precision sensor connectable between the plurality of corresponding circuit breakers and a main circuit breaker for the environment;
a communication and processing unit configured to communicate with the measuring devices and configured for receiving individual consumption measurement data representative of the electricity consumption of each of the plurality of electrical appliances;
the communication and processing unit being configured to communicate with the at least one precision sensor and being configured for receiving an overall consumption measurement data representative of the overall electricity consumption of the plurality of electrical appliances; and
wherein the communication and processing unit is adapted to apply a calibration algorithm to the individual consumption measurement data to increase precision thereof using the overall consumption measurement data.

US Pat. No. 10,191,093

DEVICE FOR MEASURING VOLTAGE ACROSS A REMOTE LOAD

Hanchett Entry Systems, I...

1. A device for measuring voltage across a remote load, comprising:a) a power supply coupled to the remote load by a pair of wires, the power supply comprising:
i) a power output module configured to output a first output voltage to the remote load;
ii) a receiver configured to receive voltage information from the remote load; and
iii) a first switch unit configured to selectively couple respective first ends of the pair of wires to either the power output module or the receiver;
b) a measuring circuit coupled to the load and configured to measure a load voltage across the load, the measuring circuit comprising:
i) a load capacitor connected in parallel with the load wherein the load capacitor supplies the load voltage to the load when the first switch is selected to couple the respective first ends of the pair of wires to the receiver;
ii) a first analog to digital (A/D) converter, the first A/D converter configured to measure the load voltage supplied by the load capacitor and packet the measured load voltage into the voltage information;
iii) a transmitter in communication with the first A/D converter, the transmitter configured to receive the voltage information from the first A/D converter and transmit the voltage information to the receiver; and
iv) a second switch unit configured to selectively couple respective second ends of the pair of wires to either the load or the receiver,
wherein when the first switch unit couples the respective first ends of the pair of wires to the power output module, the second switch unit is selected to couple the respective second ends of the pair of wires to the load, and wherein when the first switch unit is selected to couple the respective first ends of the pair of wires to the receiver, the second switch unit is selected to couple the respective second ends of the pair of wires to the transmitter.

US Pat. No. 10,191,084

PROGRAMMABLE SELF-ADJUSTING RESISTANCE SOURCE

IET Labs, Inc., West Rox...

1. An apparatus comprising:resistance circuitry having a plurality of resistors in a dynamically-configurable arrangement;
a user interface including input circuitry;
a set of output terminals configured to provide an electrical signal to a measurement device;
a communications port configured to communicate with the measurement device; and
control circuitry, the control circuitry being constructed and arranged to:
receive a target resistance from a user via the input circuitry;
assign a first arrangement of the resistance circuitry that nominally provides the target resistance based on known resistance values of the plurality of resistors;
configure the resistance circuitry according to the assigned first arrangement, thereby providing a first resistance across the set of output terminals;
subsequently, receive a resistance measurement from the measurement device via the communications port;
in response to receiving the resistance measurement, assign a second arrangement of the resistance circuitry based on a difference between the target resistance and the resistance measurement; and
configure the resistance circuitry according to the assigned second arrangement, thereby providing a second resistance across the set of output terminals, the second resistance being closer to the target resistance than was the first resistance.

US Pat. No. 10,191,081

MEASURING METHOD FOR ATOMIC FORCE MICROSCOPE

Korea Research Institute ...

1. A measuring method for an atomic force microscope that scans a surface of a sample with a probe to measure a surface property of the sample, the measuring method comprising:detecting a motion of the probe while vibrating the probe on the surface of the sample;
acquiring surface information on the sample by using a variation in the motion of the probe wherein the surface information on the sample comprises a position and a slope of the surface; and
controlling the probe by using the surface information on the sample,
wherein the vibrating the probe on the surface of the sample comprises performing a circular motion of the probe around an axis perpendicular to both a scan direction of the probe and a height direction of the sample.

US Pat. No. 10,191,079

METHOD AND SYSTEM OF DUAL-MODE ACTUATION AND SENSING FOR REAL-TIME CALIBRATION OF AXISYMMETRIC RESONANT GYROSCOPES

GEORGIA TECH RESEARCH COR...

1. A gyroscope apparatus having a plurality of resonance modes comprising:a resonator body;
first and second drive electrodes coupled to the resonator body;
first and second output electrodes coupled to the resonator body;
interface circuitry for driving the first drive electrode and second drive electrode simultaneously with a primary calibration signal derived at least in part from output signals from the first and second output electrodes; and
interface circuitry for generating calibration stimulus by multiplying the output signals of the first and second output electrodes with opposite polarities of a calibration signal, Vcal, and adding the multiplier outputs in a cross-coupled configuration to the drive signals of second and first drive electrodes to mimic mechanical rotation in an electrical domain, thereby tracking variations of mechanical rotation rate sensitivity.

US Pat. No. 10,191,078

ACCELERATION SENSOR

Panasonic Intellectual Pr...

1. An acceleration sensor comprising:a detection device including:
an active layer;
a base layer;
an oxide layer disposed between the active layer and the base layer;
a first insulating layer disposed on the active layer at a side opposite to the oxide layer and provided with a first opening;
a contact portion disposed on a part of the first insulating layer at a side opposite to
the active layer and including a first metal layer connected to the active layer through the first opening, and
a self-check electrode disposed at a side of the first insulating layer opposite to the active layer and located away from the first metal layer;
an opposed electrode disposed at a location opposing the self-check electrode; and
a top lid supporting the opposed electrode,
wherein the detection device further includes a frame and a ground electrode disposed on the frame, and
the ground electrode is electrically connected to a part of the active layer in the frame through the contact portion.

US Pat. No. 10,191,073

APPARATUS AND METHOD FOR PROCESSING AT LEAST ONE SAMPLE

Roche Diagnostics Operati...

1. An apparatus for processing at least one sample, the apparatus comprising:a processing chamber;
a first input for inputting at least a first vessel into the processing chamber;
a second input for inputting at least a second vessel into the processing chamber, wherein the second input is different from the first input;
a rotor, wherein the rotor is formed as a segment of a cylinder, the rotor comprising at least a first compartment located at a first angular position along the rotor cylinder for receiving the first vessel from the first input and a second compartment located at a second angular position along the rotor cylinder for receiving the second vessel from the second input;
a gripping device adapted to at least grip the first vessel and to transport the first vessel from the first input to the first compartment of the rotor; and
a pipetting device adapted to at least pipette a sample from the first vessel and/or the second vessel, wherein the rotor is rotatable at least between a first processing position, at which the first vessel is transportable to the first compartment of the rotor by the gripping device, a second processing position, at which the second vessel is loadable into the second compartment of the rotor from the second input, and a third processing position, at which the sample of the first vessel and/or the second vessel is aspiratable by the pipetting device.

US Pat. No. 10,191,072

REAGENT AND SAMPLE HANDLING DEVICE FOR AUTOMATIC TESTING SYSTEM

Abbott Laboratories, Abb...

1. An apparatus comprising:a loading platform of a diagnostic analyzer, the loading platform having a slot to receive a carrier;
a sensor to detect a presence of the carrier in the slot, the sensor including:
an arm pivotably coupled to the loading platform, the arm extending at least partially into the slot, the arm pivoted when the carrier is disposed in the slot and engages the arm; and
an optical detector to detect a position of the arm and determine a presence or absence of the carrier based on the position of the arm; and
a status indicator that provides a first display when the carrier is not present in the slot and provides a second display when the sensor detects the carrier in the slot.

US Pat. No. 10,191,066

METHOD FOR DETERMINING THE RISK OF CARDIOVASCULAR EVENTS USING IGFBP FRAGMENTS

HYTEST LTD., Turku (FI)

6. A cardiac test kit, said kit comprising:1) an anti insulin-like growth factor-binding protein 4 (IGFBP-4) fragment antibody that binds the N-terminal fragment from IGFBP-4 having SEQ ID NO 1,
2) an anti IGFBP-4 fragment antibody that binds the C-terminal fragment from IGFBP-4 having SEQ ID NO 2; and
3) at least one reagent that measures another marker of major adverse cardiovascular event prediction selected from the group consisting of cholesterol fraction, C-Reactive Protein (CRP), cardiac troponin I, cardiac troponin T, B-type natriuretic peptide (BNP), BNP precursor peptide (proBNP), N-terminal proBNP (NT-proBNP), Lipo-protein associated phospholipase A2 (Lp-PLA2), placental growth factor (PlGF), estimated glomerular filtration rate (eGFR), homocysteine (HCY), choline, ischemia modified albumin (IMA), soluble CD40 ligand (sCD40L) and myeloperoxidase (MPO),
wherein antibody 1) is suitable for determination of the amount of intact IGFBP-4+IGFBP-4 N-terminal fragment in the sample,
wherein said antibody 1) and antibody 2) combined are suitable for determination of the amount of intact IGFBP-4.

US Pat. No. 10,191,063

BRUCELLOSIS, Q-FEVER, AND LYME DISEASE BIOMARKERS AND USES THEREOF

Caprion Proteomics Inc., ...

1. A method for detecting HISTH4, LDHB, and MDH1 in a subject,obtaining a fluid sample(s) from a subject suspected of having Brucellosis,
detecting whether HISTH4, LDHB, and MDH1 are present in the fluid sample(s) by ionizing the fluid sample(s) and detecting charged particles corresponding to HISTH4, LDHB, and MDH1;
thereby detecting HISTH4, LDHB, and MDH1 in a subject suspected of having Brucellosis.

US Pat. No. 10,190,957

CALCULATION-BASED VEHICLE CABIN FILTRATION PERFORMANCE

Ford Global Technologies ...

1. A method for determining a vehicle passenger cabin particulate contaminant concentration value comprising:by a vehicle controller including a processor, storage, and memory:
receiving an input indicative of a vehicle-exterior atmospheric particulate contaminant concentration value from data provided by one or both of a vehicle-mounted particulate sensor or a remotely located particulate sensor;
receiving an input indicative of a passenger cabin air filter efficiency value from data provided by one or more of a passenger cabin air filter airflow sensor, a heating, air-conditioning, and ventilation (HVAC)-associated torque sensor, an HVAC blower current sensor, and an HVAC mode sensor;
receiving an input indicative of a vehicle heating, ventilation, and air conditioning (HVAC) airflow rate value from data provided by one or more of an HVAC setting sensor, the HVAC mode sensor, and the HVAC blower current sensor;
receiving an input indicative of a passenger cabin leakage rate value from data provided by the HVAC setting sensor and a vehicle speed sensor; and
by the vehicle controller, calculating a passenger cabin particulate contaminant concentration value as a function of the vehicle-exterior atmospheric particulate contaminant concentration value, the passenger cabin air filter efficiency value, the HVAC airflow rate value, and the passenger cabin leakage rate value.

US Pat. No. 10,190,944

DYNAMOMETER-SYSTEM DYNAMO CONTROL DEVICE AND ENGINE STARTING METHOD THEREFOR

MEIDENSHA CORPORATION, T...

1. A dynamo control device for a dynamometer system, the dynamometer system including a dynamometer that is coupled to an output of an engine serving as a test piece with a shaft, a torque detector that detects torsion torque in the shaft and an inverter that supplies power to the dynamometer, the dynamo control device generating a torque current command signal for the inverter based on a torque detection signal of the torque detector and a torque command signal corresponding to a command for the torque detection signal, the dynamo control device comprising:a gain calculation unit which multiplies a difference between the torque command signal and the torque detection signal by a predetermined gain;
an integration operation unit which integrates an output signal of the gain calculation unit;
a high-pass filter that passes only a component on a high-frequency side with respect to a predetermined response frequency and attenuates a component on a low-frequency side with respect to the response frequency; and
a torque current command signal generation unit which generates the torque current command signal by superimposing, on an output signal of the integration operation unit, an output signal obtained by inputting the torque detection signal to the high-pass filter.

US Pat. No. 10,190,937

HIGH-G SHOCK TESTING MACHINE

OMNITEK PARTNERS LLC, Ro...

1. A shock testing machine comprising:a test platform upon which one or more objects to be tested are mounted;
one or more rails upon which the test platform is movable; and
a braking station having one or more braking elements operatively engageable with one or more corresponding braking surfaces on the test platform after the test platform has moved a predetermined distance relative to the braking station, wherein the one or more braking elements are movable to vary a gap between the one or more braking elements and the one or more braking surface; and
the one or more braking elements comprise a beveled region such that a portion of the braking element in the beveled region has a thickness that increases with a direction of travel of the test platform.

US Pat. No. 10,190,889

COUNTING SENSOR FOR COUNTING THE NUMBER OF REVOLUTIONS OR OF LINEAR DISPLACEMENTS OF AN OBJECT

AVAGO TECHNOLOGIES INTERN...

1. Counting sensor for counting the number of revolutions or of linear displacements of an object, wherein the counting sensor comprises:one single Wiegand module, which is composed of a Wiegand wire having a coil which encloses the Wiegand wire;
at least one sensor element;
a processing electronics, which is connected to the sensor element and configured to evaluate an output signal that is output from the sensor element; and
a permanent magnet arrangement, which is movable relative to the Wiegand module in one direction as well as in a direction that is opposite to said one direction, wherein the permanent magnet arrangement is configured to be arranged at the object such that the permanent magnet arrangement performs the revolutions or the linear displacements together with the object; wherein:
upon movement of the permanent magnet arrangement in said one direction, the coil of the Wiegand module generates a voltage impulse, if a north pole or a south pole of the permanent magnet arrangement is located at a first position, and, upon movement of the permanent magnet arrangement in said opposite direction, the coil of the Wiegand module generates the voltage impulse, if the north pole or the south pole of the permanent magnet arrangement is located at a second position that is different from the first position,
in an autonomous mode, in which the counting sensor is not supplied with outside energy, the processing electronics is supplied with energy that is provided by the Wiegand module,
the processing electronics is configured, after detecting the voltage impulse that is output from the Wiegand module, to
(i) obtain, by an evaluation of the output signal of the sensor elements, direction information indicating whether the permanent magnet arrangement moves in said one direction or in said opposite direction, and (ii) to obtain, by an evaluation of the output signal of the sensor element or by a determination of the polarity of the voltage impulse that is generated by the coil of the Wiegand module, magnetic pole information indicating whether the north pole or the south pole of the permanent magnet arrangement is located at said first or said second position; and
a data storage for storing a value, which indicates the number of the revolutions or of the linear displacements; wherein
the processing electronics is configured (i) to incorporate both the direction information and the magnetic pole information in a sequence, to determine the number of the revolutions or of the linear displacements of the object on the basis of the direction information and the magnetic pole information, and to store the corresponding value in the data storage, (ii) to perform, on the basis of the sequence of the direction information and the magnetic pole information, an error detection indicating whether one of the revolutions or one of the linear displacements of the object has not been detected partially or completely, and (iii) upon detection of the error, to determine a corresponding correction of said number and to correct said value.

US Pat. No. 10,190,861

MEASURING DEVICE AND RELATED METHODS

Delcam Limited, Birmingh...

1. A non-transitory machine-readable medium encoding instructions for controlling a measuring device arranged to take measurements of a part using one or more probes, wherein the instructions, when executed by a processing apparatus, cause the processing apparatus to perform operations comprising:determining first positions along an edge region of the part, wherein each of the first positions is a position at which a surface touch measurement is to be performed by moving at least one probe tip of the one or more probes into contact with a surface of the part;
receiving surface touch measurements along the edge region of the part in response to the measuring device being instructed to move at least one probe tip of the one or more probes into contact with the surface of the part at each of the first positions;
calculating second positions along the edge region of the part based on the surface touch measurements along the edge region of the part, wherein each of the second positions is a position at which an edge measurement is to be performed by moving at least one probe tip of the one or more probes into contact with an edge of the part; and
providing the second positions to instruct the measuring device to move at least one probe tip of the one or more probes into contact with the edge of the part at each of the second positions.

US Pat. No. 10,190,842

TOY PROJECTILE LAUNCH SYSTEM

Mattel, Inc., El Segundo...

1. A toy projectile launch system comprising:a launch base comprising
a switch movable between a restricted state and an unrestricted state,
a biasing member configured to bias the switch to the restricted state,
a stop configured to be moved by the switch when the switch is moved from the restricted state to the unrestricted state, and
a trigger assembly separate from the switch and comprising a fixed portion movably coupled to a free portion;
a projectile comprising
a resilient member configured to removably couple the projectile to the launch base; and
a receiving surface configured to receive the stop when the projectile is coupled to the launch base and the switch is in the restricted state; and
an activating device configured to be removably coupled to the launch base;
wherein coupling the activating device to the launch base causes the switch to move to the unrestricted state;
wherein removing the activating device from the launch base causes the biasing member to return the switch to the restricted state;
wherein, when the switch is in the unrestricted state and the projectile is coupled to the launch base, the free portion of the trigger assembly is configured to apply a force to the resilient member and launch the projectile when the free portion is moved with respect to the fixed portion; and
wherein, when the switch is in the restricted state and the projectile is coupled to the launch base, the stop prevents the free portion of the trigger assembly from launching the projectile when the free portion is moved with respect to the fixed portion.

US Pat. No. 10,190,824

TAPHOLE ASSEMBLY, METHOD FOR MANUFACTURING A TAPHOLE ASSEMBLY, AND METALLURGICAL FURNACE

Outotec (Finland) Oy, Es...

1. A method for manufacturing a taphole assembly for arranging in a taphole assembly opening extending through a shell and a refractory lining of a metallurgical furnace such as of a pyrometallurgical furnace and for leading melt from the inside of the metallurgical furnace to the outside of the metallurgical furnace,wherein the method comprises a first providing step for providing a frame section of metal to be arranged in a taphole assembly opening extending through a shell and a refractory lining of a metallurgical furnace,
providing the frame section of metal with a seat for at least one refractory insert channel element,
a second providing step for providing at least one refractory insert channel element having a channel for melt,
arranging said at least one refractory insert channel element having a channel for melt in the seat of the frame section of metal,
providing in the first providing step a frame section of metal comprising at least two identical frame parts of metal, and
a third providing step for providing a separate face plate of metal,
releasable fastening the separate face plate of metal to said at least two identical frame parts of metal at an end face of the taphole assembly, and
providing the frame section of metal with a seat for at least one refractory insert channel element so that said at least two identical frame parts of metal are connectable such that a connection face between said at least two identical frame parts of metal forms the seat for the refractory insert channel element such that an identical longitudinal open-sided groove forming a part of said seat for at least one refractory insert channel element is formed in each of said at least two identical frame parts of metal wherein the method comprises a fourth providing step for providing a fastener for fastening the taphole assembly to a metallurgical furnace, and releasable fastening the fastener to said at least two identical frame parts of metal so that the fastener at least partly surrounds said at least two identical frame parts of metal.

US Pat. No. 10,190,790

ENERGY EFFICIENT THERMOSTAT

Digi International Inc., ...

1. A thermostat for controlling a first device and a second device in a HVAC system, comprising:a first demand circuit associated with the first device;
a second demand circuit associated with the second device;
a first limited current source and a second limited current source connected to the first and second demand circuits, respectively;
an energy storage device connected to the first and second current sources;
a DC regulator connected to the energy storage device; and
a thermostat control connected to the DC regulator and to the energy storage device;
wherein the thermostat control includes a charge monitor, sleep/wake logic and a thermostat processing engine, wherein the thermostat processing engine is configured to activate one or more of the demand circuits as a function of a heating/cooling profile, wherein the charge monitor monitors energy stored in the energy storage device; and
wherein the first limited current source provides a first limited current to the energy storage device when the first demand circuit is not activated;
wherein the second limited current source provides a second limited current to the energy storage device when the second demand circuit is not activated;
wherein the sleep/wake logic is configured to place the thermostat control in alternating periods of sleep state and wake state based on the amount of energy stored in the energy storage device, power requirements of the thermostat control during periods of sleep state being less than power requirements of the thermostat control during periods of wake state;
wherein each of the first limited current and the second limited current is insufficient for power requirements of the thermostat control during periods of wake state;
wherein each of the first limited current source and the second limited current source is configured to charge the energy storage device during periods of sleep state;
wherein the sleep/wake logic is configured to maintain the sleep state of the thermostat control at least until the amount of energy on the energy storage device is sufficient for the power requirements of the thermostat control during a subsequent wake state.

US Pat. No. 10,190,787

HUMIDIFICATION AND AIR CLEANING APPARATUS

LG ELECTRONICS INC., Seo...

1. A humidification and air cleaning apparatus comprising:a water tank to store water, the water tank comprising a bottom wall and a side wall extending upward from the bottom wall;
an air wash inlet formed at the side wall to communicate with the inside and outside of the water tank;
a water tank humidification medium housing located inside the wall or in the air wash inlet, the water tank humidification housing being detachably mounted to the water tank; and
a water tank humidification medium formed of a water absorbent material to humidify air passing through the air wash inlet, the water tank humidification medium being disposed in the water tank humidification medium housing,
wherein the water tank humidification medium covers the air wash inlet,
wherein the water tank humidification medium includes a lower end and an upper end, the lower end being spaced apart from a water surface of the water tank.

US Pat. No. 10,190,786

HUMIDIFYING AIR CLEANER

COWAY CO., LTD., Chungch...

1. A humidifying air cleaner comprising:a housing having an internal space and having a barrier member dividing the internal space; and a filter disposed at the front of the barrier member;
a humidifying unit provided in the housing to be disposed on a lower portion of the barrier member; and
a blower disposed on a rear surface of the barrier member and configured by a two-way suction fan,
wherein the barrier member comprises a first air inlet allowing the air to flow in the humidifying unit, the humidifying unit disposed in the rear of the first air inlet, and a second air inlet disposed on an upper portion of the first air inlet,
the barrier member comprises a rib increasing the amount of air flowing to the first air inlet,
the rib comprises a circular portion disposed adjacent to the second air inlet, and an extending portion extending from the circular portion, and
an inner space formed by the barrier member and the filter unit includes a lower portion through which the air is introduced into the first air inlet by the circular portion of the rib and the extending portion of the rib, and an upper portion through which the air is introduced into the second air inlet wherein the rib is disposed between the first air inlet and the second air inlet, and separates the first air inlet and the second air inlet from each other; wherein the first air inlet has a funnel shape, the funnel shape having a passage of a cross section narrowing toward the inside of the first air inlet; and wherein the first air inlet comprises a flange to stop a humidifying filter of the humidifying unit.

US Pat. No. 10,190,782

GAS OVEN

Samsung Electronics Co., ...

1. A gas oven comprising:a body;
a cooking space formed in the body;
a burner provided in the cooking space;
an inner wall configured to form the cooking space;
an air supply flow channel configured to connect the cooking space with an outside of the body to supply external air from the outside of the body to the cooking space; and
a distribution unit provided at an ejection portion of the air supply flow channel, the ejection portion of the air supply flow channel formed in the inner wall and the distribution unit formed within the cooking space on the inner wall and configured to distribute the external air supplied through the air supply flow channel,
wherein the distribution unit comprises:
a distribution guide portion configured to distribute the external air supplied through the air supply flow channel; and
a supply guide portion configured to guide the external air that passes through the distribution guide portion to be supplied to one of the cooking space and the burner,
wherein the supply guide portion is formed on the inner wall along a whole circumference of the distribution guide portion, so that the distribution unit is configured to bend a flow of the external air supplied through the air supply flow channel to supply the air to the cooking space along the inner wall.

US Pat. No. 10,190,759

CIRCUIT BOARDS FOR LED-BASED LIGHT FIXTURES

HUBBELL INCORPORATED, Sh...

1. A light fixture comprising:a master board having an input to receive AC power, an AC-DC rectifier coupled to receive AC power and generate DC power, and a power output connector to supply DC power; and
a first light-emitting diode (LED) board having a first end and a second end, and coupled to receive the DC power, the first LED board comprising:
a first LED array;
a first linear AC driver coupled to receive the DC power and drive a current through the first LED array;
a power input connector connectable to the power output connector and connected to the first linear AC driver;
a first power input/output connector positioned at the first end, and connected to the power input connector; and
a second power input/output connector positioned at the second end, and connected to the power input connector and the first power input/output connector.

US Pat. No. 10,190,753

SEALED AND SEALABLE SCALABLE LIGHTING SYSTEMS INCORPORATING FLEXIBLE LIGHT SHEETS AND RELATED METHODS

COOLEDGE LIGHTING INC., ...

1. A system of lighting components for illuminating an arbitrary two-dimensional area, the system comprising:a plurality of assemblable illumination elements, each illumination element comprising:
a substrate;
first and second spaced-apart power conductors disposed over the substrate;
a plurality of light-emitting elements that are spaced apart and interconnected into one or more light-emitting strings, each light-emitting string (i) comprising a control element disposed over the substrate and electrically connected to the light-emitting elements in the light-emitting string and configured to provide a predetermined current to the light-emitting elements in the light-emitting string, (ii) comprising two or more of the light-emitting elements, (iii) having a first end electrically connected to the first power conductor, and (iv) having a second end electrically connected to the second power conductor; and
one or more electrical connectors each electrically coupled to at least one of the first or second power conductors,
wherein each illumination element has a different shape defined by a one-dimensional or two-dimensional contiguous arrangement of illumination unit cells, each illumination unit cell (i) being polygonal, (ii) encompassing at least one light-emitting string, and (ii) emitting light at a predetermined luminous flux density, such that the predetermined luminous flux density of each illumination element is within ±10% of the predetermined luminous flux density of any other illumination element.

US Pat. No. 10,190,749

LED TUBE LAMP

Jiaxing Super Lighting El...

1. An LED tube lamp, comprising:a lamp tube, having an LED light bar disposed inside the lamp tube with a plurality of LED light sources on the LED light bar;
two end caps respectively at two opposite ends of the lamp tube; and
a power supply in one or separately in both of the end caps,
wherein each of the end caps comprises:
an electrically insulating tube;
a magnetic metal member, disposed on an inner circumferential surface of the electrically insulating tube;
a hot melt adhesive disposed on an inner circumferential surface of the magnetic metal member; and
two conductive pins disposed on the electrically insulating tube,
wherein the hot melt adhesive comprises phenolic resin 2127, shellac, rosin, calcium carbonate powder, and zinc oxide.

US Pat. No. 10,190,748

BACKLIGHT MODULE

AU OPTRONICS CORPORATION,...

1. A backlight module, comprising:a reflecting base;
a light source, disposed on the reflecting base;
at least one 3D optical control structure, disposed on the reflecting base and covering the light source, comprising a top portion and two sidewalls connected to the top portion, wherein the two sidewalls face the reflecting base obliquely and opposite to each other, and at least one of the sidewalls comprises a first through-hole; and
at least one illumination adjusting structure, adjacent to the sidewall having the first through-hole, wherein an orthogonal projection of the first through-hole to the reflecting base is projecting at a first position, and a normal line of the sidewall passing through the first through-hole intersects the reflecting base is projecting at a second position;
wherein an illumination adjusting section is between the first position and the second position, and the at least one illumination adjusting structure is disposed in the illumination adjusting section; wherein the illumination adjusting structure comprises a plurality of holes, a light-absorbing ink layer, a light-absorbing adhesive layer, a rough surface, or a combination thereof.

US Pat. No. 10,190,725

LOAD SUPPORT APPARATUS

CANON FINETECH NISCA INC....

1. A load support apparatus, comprising:a fixed support unit;
a fixed-side slit provided in the fixed support unit and extending in a predetermined direction;
a movable support unit for receiving a load, being movable with respect to the fixed support unit in a predetermined range along the predetermined direction;
a movable-side slit provided in the movable support unit and extending in the predetermined direction;
a fixed cam that is arranged at the fixed support unit, having a fixed cam face;
a cam groove that is arranged at the movable support unit and extended in a direction intersecting with a movement direction of the movable support unit, having a first movable cam face and a second movable cam face opposed to each other;
a cam follower that is movable in the cam groove along the cam groove, being contacted to the first movable cam face or the second movable cam face;
a first spring that is arranged between the fixed support unit and the movable support unit so as to support the load;
a second spring that urges the cam follower to the fixed cam face; and
a regulating member in a shape of a plate, that is detachably interposed between the fixed-side slit and the movable-side slit, regulates movement of the movable support unit with respect to the fixed support unit and extends in the predetermined direction,
wherein a reaction force from the fixed cam face to the cam follower includes a component in a first direction along the movement direction of the movable support unit and a component in a second direction at least perpendicular to the movement direction of the movable support unit, the components occurring depending on a position in the predetermined range where the movable support unit is movable,
the fixed cam face has a cam shape so that a load acting around the cam follower, an urging force of the first spring, a reaction force from the fixed cam face to the cam follower, and an urging force of the second spring are balanced around the cam follower in the predetermined range where the movable support unit is movable,
the fixed-side slit includes a fixed-side engaging portion engaging the regulating member at one end in the predetermined direction,
the movable-side slit includes a movable-side engaging portion engaging the regulating member at another end opposite to the one end in the predetermined direction, and
in a state that the load is not supported by the movable support unit, the regulating member is engaged with the movable-side engaging portion and engaged with the fixed-side engaging portion with the urging force of the first spring, and the regulating member is locked between the fixed-side engaging portion and the movable-side engaging portion with the urging force received from the movable-side engaging portion and a reaction force received from the fixed-side engaging portion.

US Pat. No. 10,190,695

CONVERTIBLE CHECK VALVE

Cornell Pump Company, Cl...

1. A convertible check valve comprising:a first valve body section having a first passageway extending therethrough, said first passageway having a first longitudinal axis, said first body section including a first flange at one end thereof, said first flange having a first end surface extending at an angle of 45 degrees to said first longitudinal axis and at which said first passageway terminates, whereupon a shape of said first passageway at said first end surface is elliptical to establish a first elliptical shaped flow port thereat;
a second valve body section having a second passageway extending therethrough, said second passageway having a second longitudinal axis, said second body section including a second flange at one end thereof, said second flange having a second end surface extending at an angle of 45 degrees to said second longitudinal axis and at which said second passageway terminates, whereupon a shape of said second passageway at said second end surface is elliptical to establish a second elliptical shaped flow port thereat, said second end surface of said second flange being configured to be connected to said first end surface of said first flange in either an aligned configuration or an angled configuration, wherein said first and second longitudinal axes are collinear when in said aligned configuration and are perpendicular to each other when in said angled configuration; and
a flapper valve member configured to be moved between a closed state and an opened state, and vice versa, said flapper valve member being configured to close said elliptical flow ports and thereby isolate said second passageway from said first passageway when said flapper valve member is in said closed state, said flapper valve member being configured to open said elliptical flow ports to enable fluid communication between said second passageway and said first passageway through said elliptical flow ports when in said opened state,
wherein said second valve body section additionally comprises a recess to receive the flapper valve member when in the opened state, and
wherein, when positioned within the recess, the flapper valve member is outside an area of a flow path between the first and second elliptical shaped flow ports.

US Pat. No. 10,190,692

FLEXIBLE METAL SEAL ASSEMBLY

SENIOR IP GmbH, Schauffh...

1. A flexible metal seal assembly configured for use in hermetically isolating at least one fluid within an operative region of a machine, said flexible metal seal assembly comprising:a first flexible metal seal configured to be positioned within said operative region, said first flexible metal seal having an inner surface, an outer surface, a top end and a bottom end opposite said top end, a first diameter and a first spring constant; and
at least a second flexible metal seal configured to be positioned within said operative region, said second flexible metal seal having an inner surface, an outer surface, a top end and a bottom end opposite said top end, a second diameter and a second spring constant;
at least a first substantially rigid metallic coupler having a substantially cylindrical shape, said metallic coupler having an inner surface, an outer surface, a top end and a bottom end opposite said top end,
at least a first portion of said metallic coupler being restrainably and hermetically attached to the inner surface of said first flexible metal seal, and at least a second portion of said metallic coupler being restrainably and hermetically attached to the outer surface of said second flexible metal seal, said first portion of said metallic coupler being closer to the bottom end of said metallic coupler than said second portion of said metallic coupler,
said outer surface of said first flexible metal seal being configured to create an outer containment region for containing a first volume of fluid within said operative region of said machine,
said inner surface of said second flexible metal seal being configured to create an inner containment region for containing a second volume of fluid,
said first and second flexible metal seals being concentric about a common longitudinal axis, and cooperating with one another to alternatively extend and compress simultaneously, in series,
each of said first and second flexible metal seals being configured to serve as a biasing member, at least during operation, relative to the movement of a reciprocating actuator located within said operative region, said actuator being positioned substantially along said common longitudinal axis,
the compression of said first flexible metal seal occurring during the compression of said second flexible metal seal, and the extension of said first flexible metal seal occurring during the extension of said second flexible metal seal,
said first volume of fluid contained in said outer containment region being hermetically isolated from, and not in fluid communication with, said second volume of fluid contained in said inner containment region,
said first and second flexible metal seals jointly describing a dual seal configured to preclude the migration of a first fluid located within said operative region.

US Pat. No. 10,190,651

MULTI-STAGE DAMPING ASSEMBLY

BeijingWest Industries Co...

11. An assembly for multi-stage damping comprising;a decoupler (36) having a radius extending between a center point (C) and an outer ring (38) and having a first surface (40) opposite a second surface (42),
a central elastomer membrane (62) extending about said center point (C),
said decoupler (36) defining a circular zone (68) extending about said center point (C) and an annular zone (70) including a plurality of rings (38, 46, 54) extending axially from said first surface (40) and extending axially from said second surface (42) and extending annularly about said central elastomer membrane (62) and separated by grooves (50, 52, 56, 58) in said first surface (40) and said second surface (42) between said outer ring (38) and said central elastomer membrane (62), and
wherein said annular zone (70) flexes between a first mode and a second mode with said first mode being defined as said annular zone (70) flexing with said circular zone (68) to maximize the potential volume of displacement and said second mode being defined as said annular zone (70) flexing independently of said circular zone (68) to decrease the potential volume of displacement of said decoupler (36) between said first chamber (30) and said second chamber (32).

US Pat. No. 10,190,628

MAGNETIC BEARING AND CENTRIFUGAL COMPRESSOR

Green Refrigeration Equip...

1. A magnetic bearing, comprising:a revolving shaft;
an electromagnetic component comprising an iron core with a winding slot, and with coils arranged in the winding slot;
a thrust plate fixed on the revolving shaft; and
a protection mechanism configured to prevent the revolving shaft from colliding with the electromagnetic component;
wherein the electromagnetic component is arranged around an outer periphery of the revolving shaft; a gap is formed between the electromagnetic component and the revolving shaft to provide space for adjusting a position of the revolving shaft; and
wherein the protection mechanism is fixed in the winding slot on the electromagnetic component and arranged around an outer periphery of the thrust plate.

US Pat. No. 10,190,614

FIXING DEVICE

1. A fixing device adapted to be mounted on a wall for connection with an object holder, said fixing device comprising:a fixing member adapted to be mounted on the wall;
a hollow shell body made of metal, having first and second end surfaces, and being formed with a through groove that has a first groove portion extending through said first end surface in a first direction, and a second groove portion extending through said second end surface in a second direction which is substantially perpendicular to the first direction;
a first connecting member made of a plastic material, securely connected to said fixing member, and having a linking portion that extends in the first direction, and that is inserted into said first groove portion of said through groove;
a second connecting member made of a plastic material, adapted to be connected to the object holder, and having a connecting portion that extends in the second direction, that is inserted into said second groove portion of said through groove, and that is securely connected to said linking portion of said first connecting member;
wherein said linking portion of said first connecting member has two engaging grooves; and
wherein said connecting portion of said second connecting member has two hooks engaging respectively said engaging grooves.

US Pat. No. 10,190,603

POWER GENERATION FROM ATMOSPHERIC AIR PRESSURE

Spar Energy LLC, Montval...

1. An apparatus comprising:a chamber including an inlet that receives injected air and an outlet through which a mixture of the injected air and drawn-in ambient air exits, the chamber being defined by an enclosure having an exterior surface and an interior surface defining a substantially constant thickness;
an internal cone within the chamber between the inlet and the outlet, wherein the internal cone gradually increases in size from the inlet to the outlet, wherein a first end of the internal cone proximate to the inlet is narrower in size than a second end of the internal cone proximate to the outlet; and
a flow channel formed by space between the interior surface of the chamber and the internal cone, wherein a first interior surface of the flow channel is the interior surface of the chamber and a second interior surface of the flow channel is an exterior surface of the internal cone,
wherein the flow channel comprises:
an aperture, created by a slit extending through the substantially constant thickness of the chamber, through which ambient air external to the chamber is drawn into the flow channel; and
a velocity airfoil at a position on the second interior surface of the flow channel, the velocity airfoil spaced between the aperture and the inlet and along a longitudinal length of the flow channel.

US Pat. No. 10,190,594

VACUUM PUMP

Edwards Limited, Burgess...

1. A vacuum pump comprising:a bearing; and
a lubricant supply system for lubricating the bearing, wherein the lubricant supply system comprises:
a lubricant reservoir comprising a reservoir matrix for receiving a lubricant and a reservoir enclosure; and
a lubricant transfer arrangement in contact with the reservoir matrix for transferring lubricant from the reservoir matrix to the bearing;
wherein the lubricant reservoir further comprises a plurality of contact regions at which the reservoir matrix is in contact with the reservoir enclosure to locate the reservoir matrix in position relative to the lubricant transfer arrangement and a plurality of spacing regions located radially outward of the reservoir matrix between respective contact regions at which the reservoir matrix is spaced apart from the reservoir enclosure for receiving gas and lubricant foam caused by outgassing in the lubricant in the reservoir matrix.

US Pat. No. 10,190,592

TURBOPUMP WITH ANTI-VIBRATION SYSTEM

ARIANEGROUP SAS, Paris (...

1. A turbopump, comprising:a casing;
a turbine fed with hot gas;
a pump driven by the turbine via a shaft and fed with liquid fluid;
a hot gas exhaust pipe situated downstream from the turbine; and
a bleed-and-injection circuit comprising
a bleed pipe adapted to bleed a liquid fluid at an outlet from the pump,
a heat exchanger adapted to heat the liquid fluid as bled off so as to transform the liquid fluid into gaseous fluid, and
an injector pipe adapted to inject the gaseous fluid into an interface region of the turbopump situated between the pump and the turbine,
wherein the gaseous fluid is injected directly between first and second dynamic seals that define a dynamic sealing system that cooperates with the shaft and with the casing of the turbopump, which dynamic sealing system is located in an interface region situated between the pump and the turbine.

US Pat. No. 10,190,584

ELECTRIC PUMP

LG INNOTEK CO., LTD., Se...

1. An electric pump comprising:a motor unit including a stator, a rotor core disposed inside the stator, and a shaft coupled to the rotor core;
a first pump unit and a second pump unit which are coupled using the shaft as a coaxial axis;
a first housing in which a motor housing receiving the motor unit and a pump housing including a first pump accommodating part are integrally formed, the first pump unit being inserted in the first pump accommodating part;
a second housing coupled to the first housing to cover the first pump accommodating part and including a second pump accommodating part in which the second pump unit is inserted; and
a cover unit coupled to the second housing to cover the second pump accommodating part,
wherein each of the first pump unit and the second pump unit comprises an internal rotor coupled to the shaft and having an external lob formed thereon and an external rotor disposed outside the internal rotor and having an internal lobe formed to be engaged with the external lob,
wherein the second pump accommodating part is formed on a front face of the second housing and a rear face of the second housing covers the first pump accommodating part,
wherein the first pump accommodating part and the rear face of the second housing have a first-stage inlet port and a first-stage outlet port formed such that the first-stage inlet port and the first-stage outlet port are separated from each other, and
wherein the second pump accommodating part and an inner face of the cover unit have a second-stage inlet port and a second-stage outlet port formed such that the second-stage inlet port and the second-stage outlet port are separated from each other,
wherein the first housing includes a first-stage inlet channel connected to the first-stage inlet port and a first-stage outlet channel connected to the first-stage outlet port, and the second housing includes a second-stage inlet channel passing through the front face and the rear face to cause the first-stage outlet port and the second-stage inlet port to communicate with each other and a second-stage outlet channel connected to the second-stage outlet port.

US Pat. No. 10,190,583

POSITIVE DISPLACEMENT PUMP

MHWIRTH GMBH, Erkelenz (...

1. A positive displacement pump comprising:a drive unit; and
a pump unit comprising,
at least one inline valve unit comprising an external dimension,
four connecting and/or spacing devices, the four connecting and/or spacing devices being arranged in a rectangular shape so that a spacing exists between any two of the four connecting and/or spacing devices, and
a pair of flanges which are connected to each other via the four connecting and/or spacing devices,
wherein,
in an operating position, the at least one inline valve unit is clamped between the pair of flanges,
the at least one inline valve unit is configured to be displaced without removing any of the four connecting and/or spacing devices and without changing a spacing between the pair of flanges and the four connecting and/or spacing devices, and
the spacing between at least two of the four connecting and/or spacing devices is greater than the external dimension of the at least one inline valve unit.

US Pat. No. 10,190,563

INTERNAL COMBUSTION ENGINE IGNITION COIL AND METHOD FOR MANUFACTURING INTERNAL COMBUSTION ENGINE IGNITION COIL

Hitachi Automotive System...

1. An internal combustion engine ignition coil comprising:a central iron core;
a primary coil disposed on an outer circumference of the central iron core;
a secondary coil disposed on an outer circumference of the primary coil;
a side iron core disposed on an outer circumference of the secondary coil; and
an insulating material sealing the central iron core, the primary coil, and the secondary coil on an inner side of the side iron core, wherein
a first layered silicate having a particle diameter less than a winding diameter of the secondary coil is present at a higher concentration in a vicinity of the secondary coil than that in a vicinity of the side iron core in the insulating material,
a second layered silicate having a particle diameter greater than the winding diameter of the secondary coil is present at a higher concentration than that of the first layered silicate between the outer circumference side of the secondary coil and the side iron core, and
the second layered silicate has an aspect ratio of 50 or more, the aspect ratio being a ratio of a long side of a particle of the layered silicate to a thickness of the particle.

US Pat. No. 10,190,560

CAMERA BASED VEHICLE START-STOP FEATURE

MAGNA ELECTRONICS INC., ...

1. A stop-start control system for a vehicle, said stop-start control system comprising:a camera disposed at a vehicle and having a field of view exterior and forward of the vehicle;
a control comprising an image processor operable to process image data captured by said camera;
wherein, responsive to image processing by said image processor of image data captured by said camera, said control determines the presence of a stopping area ahead of the vehicle and being approached by the vehicle; and
wherein, responsive to determination of the presence of the stopping area ahead of the vehicle and being approached by the vehicle, and responsive to determination that the driver of the vehicle releases the accelerator pedal of the vehicle, and while the vehicle is moving toward the determined stopping area, said control shuts off the engine so the vehicle coasts toward the determined stopping area.

US Pat. No. 10,190,538

THRUST REVERSER DEVICE

1. A thrust reverser device for a turbojet engine of an aircraft comprising:a movable cowl;
translating cascades connected to the movable cowl and displaceable between a direct jet position where the translating cascades are retracted in a fan casing, and an indirect jet position where the translating cascades are brought out of the fan casing;
a mast configured to connect the turbojet engine to the aircraft; and
a front suspension configured to suspend the turbojet engine from the mast,
wherein the translating cascades have a sliding connection with the mast via at least one spacer mounted to a sidewall of the mast downstream of the front suspension,
wherein said at least one spacer comprises fixed cascades.

US Pat. No. 10,190,449

APPARATUS AND METHOD OF CONTROLLING ELECTRONIC CONTINUOUSLY VARIABLE VALVE TIMING

HYUNDAI KEFICO CORPORATIO...

1. An apparatus for controlling an electronic continuously variable valve timing (CVVT) comprising:a motor and a reducer, configured to adjust a relative rotation phase of a cam shaft that rotates with a crank shaft of a combustion engine to adjust a valve timing of a suction valve or an exhaust valve;
a sensor disposed in a border of a side of the motor facing the reducer configured to determine a rotation speed of a first projection of a first rotation member which is coupled to the crank shaft to rotate;
a second projection of a second rotation member having a rotation speed configured to be determined by the sensor which is gear-coupled to the first rotation member at a certain gear ratio and is coupled to the cam shaft to rotate, wherein the sensor is configured to output a sensing signal that corresponds to an output waveform which corresponds to each of the rotation speeds; and
an intelligent motor controller coupled to the motor, wherein the intelligent motor controller is configured to
receive the sensing signal from the sensor,
separate a crank shaft position signal that corresponds to a rotation of the first projection and a cam shaft position signal that corresponds to a rotation of the second projection from the sensing signal,
compare the crank shaft position signal and the cam shaft position signal to detect an actual phase angle of the suction valve or the exhaust valve, and
determine a phase deviation between the detected actual phase angle and a predetermined target phase angle,
wherein the first projection and the second projection are disposed along a circumferential direction of a side of the reducer facing the motor.

US Pat. No. 10,190,434

TURBINE SHROUD WITH LOCATING INSERTS

Rolls-Royce North America...

1. A turbine blade track comprisingan annular ceramic runner formed to include a plurality of cutouts extending inward in a radial direction from an outer radial surface of the annular ceramic runner toward an inner radial surface of the annular ceramic runner, and
a plurality of inserts coupled to the annular ceramic runner, each insert including a stem arranged in the cutout and a cap arranged outside the cutout that extends from the stem in a circumferential direction and in an axial direction along the outer radial surface of the annular ceramic runner.

US Pat. No. 10,190,418

GAS TURBINE ENGINE AND TURBINE BLADE

Rolls-Royce North America...

1. A turbine blade for a gas turbine engine, comprising:an airfoil body having a pressure side, a suction side, a leading edge portion having a leading edge of the airfoil body, and a trailing edge portion having a trailing edge of the airfoil body, wherein the pressure side, leading edge portion, suction side, and trailing edge portion collectively form a continuous outer surface of the airfoil body, and the airfoil body culminates at a tip surface; and
a squealer tip extending outwardly from the tip surface, said squealer tip having a pressure side rail portion extending along the pressure side wall from the leading edge portion towards the trailing edge portion and a suction side rail portion extending along the suction side wall from the leading edge portion to the trailing edge, said pressure side rail portion and suction side rail portion forming a cavity therebetween on the tip surface of the airfoil body;
wherein the squealer tip includes a passage extending between the pressure side rail portion and the suction side rail portion, said passage configured to fluidly couple the trailing edge portion to the cavity; and
wherein the entire pressure side rail portion and the entire suction side rail portion are respectively offset from the pressure side and the suction side of the airfoil body between the leading edge portion and the trailing edge portion, to define a shelf on the tip surface between each of the pressure and suction sides and the pressure side rail portion and the suction side rail portion, respectively, wherein the suction side rail portion of the squealer tip extends to the trailing edge and is coincident with the continuous outer surface only at the trailing edge of the trailing edge portion, and the pressure side rail portion terminates at an end thereof near the trailing edge portion, and defines the passage as a gap between the end of the pressure side rail portion and the suction side rail portion.

US Pat. No. 10,190,386

ZONE ISOLATION METHOD AND ANNULAR BARRIER WITH AN ANTI-COLLAPSING UNIT

Welltec Oilfield Solution...

1. An annular barrier to be expanded in an annulus between a well tubular structure and a wall of a borehole downhole for providing zone isolation between a first zone having a first pressure and a second zone having a second pressure of the borehole, the annular barrier comprising:a tubular metal part for mounting as part of the well tubular structure, the tubular metal part having an outer face,
an expandable sleeve surrounding the tubular metal part and having an inner face facing the tubular metal part and an outer face facing the wall of the borehole, each end of the expandable sleeve being connected with the tubular metal part, and
an annular space between the inner face of the expandable sleeve and the tubular metal part, the annular space having a space pressure,
wherein the annular barrier comprises an anti-collapsing unit comprising an element movable at least between a first position and a second position, the anti-collapsing unit having a first inlet which is in fluid communication with the first zone, and a second inlet which is in fluid communication with the second zone, and the anti-collapsing unit having an outlet which is in fluid communication with the annular space, and in the first position, the first inlet is in fluid communication with the outlet, equalising the first pressure of the first zone with the space pressure, and in the second position, the second inlet is in fluid communication with the outlet, equalising the second pressure of the second zone with the space pressure.

US Pat. No. 10,190,379

INNER DRILLING RISER TIE-BACK CONNECTOR SEAL

Dril-Quip, Inc., Houston...

1. An apparatus for coupling a platform to a subsea wellhead comprising:a riser extending between the platform and the subsea wellhead, wherein the riser comprises an inner riser and an outer riser;
an inner drilling riser tie-back connector (“ITBC”) having a main body, wherein the ITBC is coupled to the inner riser;
a seal positioning device disposed between the main body of the ITBC and the subsea wellhead; and
a seal disposed at an end of the seal positioning device, wherein the seal positioning device is positioning the seal at an interface directly between the main body of the ITBC and the subsea wellhead and connecting the seal to at least one other component in the annulus, wherein the seal comprises:
a main body comprising a first end and a second end opposite the first end, wherein the first end of the seal is disposed at the end of the seal positioning device and the second end of the seal extends axially away from the end of the seal positioning device;
a first inwardly projecting finger disposed on the first end of the main body of the seal and projecting at an angle axially toward the second end of the main body of the seal and radially toward a radially inner surface of the subsea wellhead;
a second inwardly projecting finger disposed on the second end of the main body of the seal and projecting at an angle axially toward the first end of the main body of the seal and radially toward the radially inner surface of the subsea wellhead, wherein the first and second inwardly projecting fingers project at opposing angles to each other; and
an outwardly projecting lever arm disposed on the second end of the main body of the seal, wherein the outwardly projecting lever arm is adjacent to and at an outward angle to the second inwardly projecting finger, wherein the outwardly projecting lever arm is projecting at an angle axially away from the first end of the main body of the seal and radially toward the radially inner surface of the subsea wellhead.

US Pat. No. 10,190,313

CONSTRUCTION BLOCK SYSTEM

1. A construction block system comprising:A) a plurality of primary blocks each having first and second longitudinal walls with upper and lower surfaces and kept at parallel and spaced apart relationship with respect to each other and further including first, second and third transversal walls each having upper and lower surfaces and extending perpendicularly to said first and second longitudinal walls to define first and second cavities, and each of said first and second longitudinal walls including first and second rectangular walls, respectively, extending outwardly and having smaller dimensions than said first and second longitudinal walls thereby defining first, second, third and fourth peripheral edge walls perpendicular to said first and second longitudinal walls and each of said first, second and third transversal walls upper and lower surfaces further including each a pair of aligned channels and said primary blocks abuttingly coacting with each other to form a structure;
B) a plurality of primary half blocks each having third and fourth longitudinal walls kept at a parallel and spaced apart relationship with respect to each other and fourth and fifth transversal walls extending perpendicularly to said third and fourth longitudinal walls defining a third cavity and each of said third and fourth longitudinal walls including third and fourth rectangular walls, respectively, extending outwardly and having smaller dimensions than said third and fourth longitudinal walls thereby defining fifth, sixth, seventh and eighth peripheral edge walls perpendicular to said third and fourth longitudinal walls, each of said fourth and fifth transversal walls having upper and lower surfaces that include a pair of aligned channels each and said primary half blocks coacting with said primary blocks to complement said structure;
C) at least one base alignment and leveling tool that includes two rails mounted on a plurality of transversal members walls and said rails kept at a parallel and spaced apart relationship with respect to each other, said rails being cooperatively received by said channels of said transversal walls lower surfaces resting on a supporting substantially horizontal surface, said transversal members include a centrally located through hole for cooperatively receiving a location fastening member that passes through penetrating and engaging said supporting surface and said transversal members thereby securing said base alignment and leveling tool at a predetermined location, said transversal members further including at least two threaded openings and corresponding leveling bolts that are matingly passed therethrough to coact with the supporting surface to level said base alignment and leveling tool and the abutting primary and primary half blocks.

US Pat. No. 10,190,295

FAUCET

PANASONIC INTELLECTUAL PR...

1. A faucet comprising:a water outlet for discharging water;
a detector that detects a detection target in a detection area containing a water discharge area in which the water discharged from the water outlet is present; and
a controller operably connected to the detector and the water outlet and that starts and ends supply of the water discharged from the water outlet based on a detection result of the detector,
the detector including
a sensor that sends a radio wave signal and receives the radio wave signal reflected by an object to output a sensor signal corresponding to motion of the object,
a frequency analyzer that applies orthogonal transform to the sensor signal to convert the sensor signal into a frequency domain signal, and extracts, by use of a group of individual filter banks with different frequency bands, signals of the individual filter banks from the frequency domain signal,
a recognizer that performs a recognition process of detecting that the object corresponds to the detection target based on detection data containing at least one of a frequency distribution of signals based on the signals of the individual filter banks and a component ratio of signal intensities based on the signals of the individual filter banks, and
a database device that stores sample data containing at least one of a frequency distribution corresponding to the detection target and a component ratio of signal intensities corresponding to the detection target, and the recognizer performs the recognition process based on comparison between the detection data and the sample data.

US Pat. No. 10,190,290

LOCK ASSEMBLY FOR A WEAR MEMBER

Bradken Resources Pty Lim...

1. A lock assembly for locking a wear member to excavation equipment, the assembly comprising first and second bodies configured to be assembled together in an assembled condition to form a lock, the lock being elongated in a direction of a longitudinal axis of the lock, the lock being adjustable between first and second configurations of the first and second bodies, wherein adjustment of the lock from the first configuration to the second configuration comprises translation of the first body with respect to the second body along a translation axis that is transverse to the longitudinal axis of the lock to extend the lock in the direction of the lock's longitudinal axis.

US Pat. No. 10,190,258

DOCTOR BLADE HOLDERS AND DOCTOR BLADE HOLDER SYSTEMS INCLUDING PLANAR ELEMENTS WITH THREE DIMENSIONAL FABRIC REINFORCEMENT MATERIALS

Kadant Inc., Westford, M...

1. A planar element for use in a papermaking system, said planar element being suitable for use as a doctor blade or a top plate, said planar element comprising:a three-dimensional composite structure including elongated elements extending in at least three orthogonal directions; and
a resin in which the three-dimensional composite structure is embedded.

US Pat. No. 10,190,255

MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PREPARATION AND THEIR USE

DyStar Colours Distributi...

1. A dye mixture comprisingone or more dye(s) of formula (I)

and
one or more dye(s) of formula (II) and/or formula (III)

and optionally
one or more dye(s) of: formula (IV)

wherein D1 and D2 independent of one another is group of formula (1)

wherein
R1 and R2 independent of one another is hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, carboxyl, amido or ureido,
X1 is hydrogen or —SO2—CH?CH2,
D3 and D4 independent of one another is a group of formula (1)
wherein
R1 and R2 independent of one another is hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, carboxyl, amido or ureido,
X1 is hydrogen or a group of the formula: —SO2—Z, wherein
Z is hydroxyl, —CH?CH2 or —CH2CH2Z1, wherein
Z1 is hydroxyl or a group which can be eliminated under the action of alkali,
R200 and R201 independent of one another is
i) hydrogen,
ii) C1-C6-alkyl, which is linear or branched and is unsubstituted or substituted by amino, (C1-C4)-alkylamino, hydroxyl, (C1-C4)-alkoxy, sulfo, halogen, carboxyl, acetamido or ureido;
iii) phenyl which is unsubstituted or substituted by (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, halogen, carboxyl, acetamido or ureido;
(iv) amino, (C1-C4)-alkylamino, hydroxyl, (C1-C4)-alkoxy, sulfo, carboxyl, cyano, halogen, nitro, amido or ureido,
R* and R** independent of one another is hydrogen, (C1-C4)-alkyl, CO-(C1-C4-alkyl) or —CH2—SO3M,
M is hydrogen, an alkali metal or one equivalent of an alkaline earth metal
and wherein the sum of weights of all dyes of formula (I) that are present in the dye mixture is at least 40% of the weight of the dye mixture —calculated on the basis of the sum of weights of all dyes according to formulae (I), (II), (III) and (IV) that are present in the dye mixture.

US Pat. No. 10,190,200

ALUMINUM-COPPER-LITHIUM PRODUCTS

CONSTELLIUM ISSOIRE, Iss...

1. A method of manufacturing an extruded product based on an aluminum alloy, said method comprising:a) preparing a liquid metal bath consisting essentially of 2.72 to 3.1% by weight of Cu, 1.59 to 1.8% by weight of Li, 0.1 to 0.5% by weight of Ag, 0.1 to 1.0% by weight of Mg, 0.05 to 0.18% by weight of Zr, 0.2 to 0.6% by weight of Mn, and at least one element selected from Cr, Sc, Hf and Ti, the quantity of said element, if included, being 0.05 to 0.3% by weight for Cr and for Sc, 0.05 to 0.5% by weight for Hf or 0.01 to 0.15% by weight for Ti,
remainder aluminum and inevitable impurities;
b) casting an unwrought shape from said liquid metal bath;
c) homogenizing said unwrought shape at a temperature from 515° C. to 525° C. such that the equivalent time for homogenization

is from 5 to 20 hours, where T (in Kelvin) is the instantaneous treatment temperature, which varies with the time t (in hours), and Tref is a reference temperature set at 793 K;
d) hot working and optionally cold working said unwrought shape into an extruded product;
e) subjecting the product to a solution treatment and quenching;
f) stretching said product with a permanent set of 1 to 5%; and
g) artificially aging said product by heating at 140 to 170° C. for 5 to 70 hours such that said product has a yield strength measured at 0.2% elongation in the L-direction of at least 517 MPa.

US Pat. No. 10,190,162

SIGNAL CONFINEMENT SEQUENCING (SCS) AND NUCLEOTIDE ANALOGUES FOR SIGNAL CONFINEMENT SEQUENCING

Complete Genomics, Inc., ...

1. A method for sequencing a target nucleic acid, comprising:a) providing a template nucleic acid immobilized on a surface, a primer, a polymerase, and a nucleotide analogue of the following structure:

 wherein
n is 0, 1, 2, 3, 4, 5, 6, or 7;
L is absent or a linking group;
R1 is a nucleoside base;
R2 is hydrogen or a blocking group;
B is a binding molecule; and
X is a detection label, wherein said detection label is quenched;
b) extending the primer by incorporating the nucleotide analogue;
c) providing a phosphatase to cleave between the binding molecule and the linking group or between the binding molecule and the terminal phosphate, thereby generating a fragment of (I) comprising the label and the binding molecule, wherein the label is unquenched;
d) binding the fragment to a capture element immobilized on a surface; and
e) detecting a fluorescence emission from the label of the fragment captured on the surface.

US Pat. No. 10,190,070

MULTIPLE-FUNCTION DISPERSANT GRAFT POLYMER

Castrol Limited, Swindon...

1. A multiple function dispersant graft polymer containing at least two different grafted monomers, each directly grafted to a polyolefin polymer backbone having a weight average molecular weight of from about 10,000 to about 1,000,000, the polyolefin polymer backbone having graftable sites, in which:a first grafted monomer comprises an ethylenically unsaturated, aromatic monomer selected from the group consisting of 1-vinylimidazole, N-allylimidazole, 2-vinylpyridine, 4-vinylpyridine, 4-methyl-5-vinyl thiazole, N-allyl diisooctyl phenothiazine, 2-methyl-1-vinylimidazole, 3-methyl-1-vinylpyrazole, N-vinylpurine, and combinations thereof; and
a second grafted monomer comprises an acylating agent with which at least one amine has been reacted, wherein said amine is selected from the group consisting of N-phenylphenylenediamines, N-phenyl-1,4-phenylenediamine, N-phenyl-1,3-phenylenediamine, N-phenyl-1,2-phenylenediamine, N-naphthylphenylenediamine, N-phenylnaphthalenediamine, N?-aminopropyl-N-phenylphenylenediamine, N-arylphenylenediamines represented by the formula:

in which Ar is aromatic and R1 is hydrogen, —NH-aryl, —NH-arylalkyl, —NH-alkylaryl, or a branched or straight chain radical having from 4 to 24 carbon atoms and the radical can be an alkyl, alkenyl, alkoxyl, arylalkyl, alkylaryl, hydroxyalkyl or aminoalkyl radical, R2 is —NH2, —NH(CH2)n—)m—NH2, —CH2—(CH2)n—NH2, -aryl-NH2, in which n and m each has a value from 1 to 10, and R3 is hydrogen or an alkyl, alkenyl, alkoxyl, arylalkyl, or alkylaryl radical, which may have from 4 to 24 carbon atoms; and

in which R4, R5, and R6 are hydrogen or a linear or branched hydrocarbon radical containing from 1 to 10 carbon atoms and that radical may be an alkyl, alkenyl, alkoxyl, alkylaryl, arylalkyl, hydroxyalkyl, or aminoalkyl radical, and R4, R5 and R6 can be the same or different;
aminocarbazoles represented by the formula:

in which R7 and R8 represent hydrogen or an alkyl, alkenyl, or alkoxyl radical having from 1 to 14 carbon atoms, and R7 and R8 can be the same or different;
aminoindoles represented by the formula:

in which R9 represents hydrogen or an alkyl radical having from 1 to 14 carbon atoms, amino-indazolinones represented by the formula:

in which R10 is hydrogen or an alkyl radical having from 1 to 14 carbon atoms, aminomercaptotriazole represented by the formula:

aminoperimidines represented by the formula:

in which R11 represents hydrogen or an alkyl or alkoxyl radical having from 1 to 14 carbon atoms and combinations thereof,
which has from about 1 mole to about 74 moles of first graft monomer per mole of backbone polymer and from about 1 mole to about 74 moles of second graft monomer per mole of backbone polymer, wherein the total moles of first graft monomer and second graft monomer per mole of backbone polymer is not greater than 75 moles;
wherein the multiple function dispersant graft polymer has a Rapid ADT response of at least 4.

US Pat. No. 10,190,056

CONVERSION OF SOLID BIOMASS INTO A LIQUID HYDROCARBON MATERIAL

SHELL OIL COMPANY, Houst...

1. A process for producing liquid hydrocarbon products from a solid biomass feedstock comprising:a) providing in a hydropyrolysis reactor vessel a hydropyrolysis catalyst composition that comprises one or more active metals selected from cobalt, molybdenum, nickel, tungsten, ruthenium, platinum, palladium, iridium and iron on an oxide support, wherein the active metals are present in a partially sulfided form to the extent that the hydropyrolysis catalyst composition contains sulfur in an amount of from 10 to 90% of a full stoichiometric amount;
b) contacting the solid biomass feedstock with the hydropyrolysis catalyst composition and molecular hydrogen in the hydropyrolysis reactor vessel at a temperature in the range of from 350 to 600° C. and a pressure in the range of from 0.50 to 7.50 MPa, to produce a product stream comprising partially deoxygenated hydropyrolysis product, H2O, H2, CO2, CO, C1-C3 gases, char and catalyst fines;
c) removing the char and catalyst fines from the product stream;
d) hydroconverting the partially deoxygenated hydropyrolysis product in a hydroconversion reactor vessel in the presence of one or more hydroconversion catalyst and of the H2O, CO2, CO, H2, and C1-C3 gas generated in step a), to produce a vapour phase product comprising substantially fully deoxygenated hydrocarbon product, H2O, CO, CO2, hydrogen and C1-C3 gases.

US Pat. No. 10,190,048

LIQUID-CRYSTALLINE MEDIUM AND LIQUID-CRYSTAL DISPLAY COMPRISING THE SAME

Merck Patent GmbH, Darms...

1. A liquid-crystalline medium comprisinga) one or more compounds selected from the group of compounds of formulae I-1 and I-2

in which
R11 and R12 independently of each other denote H or alkyl with 1 to 5 C atoms, and
b) one or more compounds selected from the group of compounds of formulae II and III

in which
R21 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkenyl radical having 2 to 7 C atoms or an unsubstituted alkoxy radical having 1 to 6 C atoms,
R22 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkoxy radical having 1 to 6 C atoms or an unsubstituted alkenyloxy radical having 2 to 6 C atoms, and
l denotes 0 or 1,
R31 denotes an unsubstituted alkyl radical having 1 to 7 C atoms or an unsubstituted alkenyl radical having 2 to 7 C atoms,
R32 denotes an unsubstituted alkyl radical having 1 to 7 C atoms, an unsubstituted alkoxy radical having 1 to 6 C atoms or an unsubstituted alkenyloxy radical having 2 to 6 C atoms, and
denotes

US Pat. No. 10,190,046

LUMINESCENT-SUBSTANCE MIXTURE, LIGHT-EMITTING SEMICONDUCTOR COMPONENT HAVING A LUMINESCENT-SUBSTANCE MIXTURE, AND STREETLAMP HAVING A LUMINESCENT-SUBSTANCE MIXTURE

OSRAM Opto Semiconductors...

1. A luminescent material mixture having a first luminescent material and a second luminescent material,wherein under excitation with blue light, an emission spectrum of the first luminescent material has a relative intensity maximum in a yellowish-green region of the spectrum at a wavelength of greater than or equal to 540 nm and less than or equal to 560 nm and an emission spectrum of the second luminescent material has a relative intensity maximum in an orange-red region of the spectrum at a wavelength of greater than or equal to 600 nm and less than or equal to 620 nm, and
the second luminescent material is selected from (Ca,Sr,Eu)AlSiN3.Si2N2O or (Ca,Sr,Ba,Eu)2Si5N8 with an Eu content of greater than or equal to 1% and less than or equal to 2.5%, with a Ba content of greater than or equal to 45% and less than or equal to 55% and with a Ca content of greater than or equal to 0% and less than or equal to 10%, wherein the Sr content is selected such that the sum of the Eu, Ba, Ca and Sr contents is 100%.

US Pat. No. 10,190,044

METHOD FOR PRODUCING ?-SIALON FLUORESCENT MATERIAL

NICHIA CORPORATION, Anan...

1. A method for producing a ?-sialon fluorescent material, comprising:providing a composition comprising a material represented by a formula: Si6-zAlzOzN8-z:Eu wherein z satisfies 0 heat-treating the composition in a rare gas atmosphere or in a vacuum; and
contacting the heat-treated composition with a fluorine-containing gas.

US Pat. No. 10,190,041

ENCAPSULATED POROUS PROPPANT

University of Utah Resear...

1. A proppant particle, comprising:a core having a plurality of inner pores;
a shell surrounding the core and including a plurality of shell pores, the shell pores being configured to house a treatment product capable of application to a subterranean formation; and
a polymer encapsulation layer surrounding the shell, the polymer encapsulation layer being permeable to the treatment product such that the treatment product is released over time to an exterior side of the polymer encapsulation layer, the polymer encapsulation layer including a microbial growth solution.

US Pat. No. 10,190,032

VISCOELASTIC SURFACTANTS IN MIXED BRINES

M-I L.L.C., Houston, TX ...

17. A method of finding of finding an optimal ratio of divalent brine to monovalent brine in a wellbore fluid including a viscoelastic surfactant, the method comprising:providing a mixture of viscoelastic surfactant and a monovalent brine;
adding a divalent brine in incremental values, wherein the initial amount of divalent brine to be added is based upon a packing parameter of the viscoelastic surfactant; and
measuring the rheological properties.

US Pat. No. 10,190,023

SILICA-BASED POLISHING PARTICLE AND ABRASIVE

JGC CATALYSTS AND CHEMICA...

1. A silica-based polishing particle having a three-dimensional polycondensation structure, whereinthe particle contains an alkoxy group therein, the particle having an average particle diameter (d) of 5 to 300 nm, an aspect ratio of 1.00 or more and 1.20 or less, and a carbon content of 0.005% by mass or more and less than 0.50% by mass.

US Pat. No. 10,190,017

PROTECTIVE FILM-FORMING FILM AND METHOD OF MANUFACTURING SEMICONDUCTOR CHIP WITH PROTECTIVE FILM

Lintec Corporation, Toky...

1. A protective film-forming film for forming a protective film which protects a metal film provided on a back surface of a semiconductor chip,wherein the protective film-forming film is formed of a protective film-forming composition to which a coupling agent having a protected thiol group is added, and
wherein the protective group in the protected thiol group includes at least one of the group consisting of a trialkoxysilyl group, a trialkylsilyl group, a trialkylsiloxy group, a carbamate group, a carbonate group, and an acetyl group, and
wherein the coupling agent has a protected thiol group at a terminal of the molecule,
wherein the coupling agent is composed of a compound represented by the following formula (1), and
wherein the protective film-forming composition includes an acrylic resin having a glass transition temperature of ?3 to 6 ° C., and
(R1O)3—Si—X1—S—Y1  formula (1)wherein R1 represents an alkyl group in which three R1s may be the same as or different from each other; X1 represents an alkylene group; and Y1 represents the protective group in the protected thiol group.

US Pat. No. 10,190,012

TREATMENT OF RELEASE LAYER AND INKJET INK FORMULATIONS

LANDA CORPORATION LTD., ...

1. A printed ink image on a substrate comprising a water-soluble or water-dispersible polymeric resin, and for which at least one of the following is true:(a) the image has an X-Ray Photoelectron Spectroscopy (XPS) peak at 402.0±0.4 eV;
(b) the image has on its outer surface distal to the substrate a polymeric chemical agent containing at least 1 wt. % of one or more chargeable nitrogen atoms and having at least one of
(1) a positive charge density of at least 3 meq/g of chemical agent and an average molecular weight of at least 250 and
(2) a molecular weight of at least 10,000;
(c) the ratio of the surface concentration of nitrogen at the outer surface of the image distal to the substrate to the bulk concentration of nitrogen within the image is at least 1.2:1;
(d) the surface concentration of secondary amines, tertiary amines, and/or an ammonium group at the image surface distal to the substrate exceeds their respective bulk concentrations at a depth of at least 30 nanometers below the surface.

US Pat. No. 10,190,009

INK COMPOSITION, INK JET RECORDING METHOD USING SAME, AND COLORED MATERIAL

NIPPON KAYAKU KABUSHIKI K...

1. An ink composition comprising a coloring matter represented by the following formula (3) and a coloring matter represented by the following formula (b4):
wherein the coloring matter represented by formula (3) is from 40% to ? by mass of the total amount of the coloring matters in the ink composition.

US Pat. No. 10,190,008

METHOD FOR PRINTING ON WATER-SOLUBLE MATERIAL

Fujifilm Imaging Colorant...

1. A method for printing on a water-soluble material which comprises the following steps:A) ink jet printing, using a printer with a single-pass print-head, an ink onto a water-soluble material so as to form an image wherein the ink comprises a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a cross-linking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups;
B) overprinting the image formed in step A) with a water soluble overprint varnish.

US Pat. No. 10,189,999

RESIN COMPOSITION FOR COATING AGENT, MOLDED ARTICLE, AND IMAGE DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A resin composition for a coating agent, comprising:a silicon compound (a) represented by formula (I); and
a curable resin (b); and
in formula (I),
R1 is a C3 or C4 alkylene group,
X is a group represented by formula (II) having a urethane skeleton and having a (meth)acryloyl group at an end,
in formula (II),
R2 is hydrogen or a methyl group,
n is an integer of 0 or 1,
a molecular weight of the silicon compound (a) is 500 to 699,

US Pat. No. 10,189,997

COLORANT INCLUDING A MIXTURE OF PIGMENTS

VIAVI Solutions Inc., Sa...

1. A colorant comprising:a first pigment; and
a second pigment,
wherein the second pigment comprises a plurality of layers,
wherein the plurality of layers include a particular layer, and
wherein the particular layer is a reflective ferrochrome (FeCr) layer.

US Pat. No. 10,189,994

USE OF A WAX-MODIFIED, AIR RECTIFIED ASPHALT IN BUILT UP ROOFING ASPHALT COMPOSITIONS

Owens Corning Intellectua...

1. A heat stable asphalt composition that meets ASTM D 312 (2006) built-up roofing asphalt (“BURA”) specifications, the heat stable asphalt composition comprising:an air rectified asphalt; and
a wax additive, wherein the additive has a melt point higher than about 100° C.;
wherein the composition has an equiviscous temperature (EVT) of from about 340° F. to about 390° F. for mopping applications and from about 380° F. to about 430° F. for mechanical applications, and wherein the composition has a minimum solubility in trichloroethylene of 99%.

US Pat. No. 10,189,991

HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1 (2H)-ONE COMONOMER UNIT

Polymics, LTD, State Col...

1. A composition, consisting essentially of a melt processable semicrystalline aromatic polyetherketone polymer according to formula (I):
wherein Cp is a phthalazinone unit of formula (II);

Q is a biphenol unit of formula (III);

Z is an aromatic ketone unit of formula (VI);

x is a value of at least 1; and
y is a value of at least 1,
wherein x and y are such that the molar ratio of Q to Cp is between about 30/70 and 90/10,
wherein the polymer has a glass transition temperature between about 180° C. and 240° C., and
wherein the melt processable semicrystalline aromatic polyetherketone polymer has an enthalpy of melting endotherm of between about 5.0 J/g and 26.0 J/g.

US Pat. No. 10,189,990

POLY(PHENYLENE ETHER) COMPOSITION AND ARTICLE

SABIC GLOBAL TECHNOLOGIES...

1. A composition comprising, based on the total weight of the composition:61 to 89 weight percent of a poly(phenylene ether);
3 to 10 weight percent of a polystyrene-poly(ethylene-butylene)-polystyrene triblock copolymer having a polystyrene content of 20 to 40 weight percent and a weight average molecular weight of 200,000 to 400,000 daltons;
6 to 12 weight percent of a flame retardant comprising an organophosphate ester; and
2 to 17 weight percent of an adhesion promoter selected from the group consisting of
(a) phenolic compounds having a molecular weight of 94 to 18,000 daltons;
(b) hydroxysilyl-terminated polydiorganosiloxanes of the formula

 wherein m is 2 to 50, and each occurrence of R1 is independently C1-C12 hydrocarbyl, provided that 5 to 60 mole percent of the occurrences of R1 are independently C6-C12 aryl; and
(c) combinations of the (a) phenolic compounds and the (b) hydroxysilyl-terminated polydiorganosiloxanes.

US Pat. No. 10,189,987

PNEUMATIC TIRE

SUMITOMO RUBBER INDUSTRIE...

1. A pneumatic tire, provided with a tread formed from a rubber composition, the rubber composition comprising:a rubber component,
silica, and
a silane coupling agent represented by Formula (1) below,
the rubber component comprising, based on 100% by mass of the rubber component, 5% to 90% by mass of a conjugated diene polymer containing a constituent unit based on a conjugated diene and a constituent unit represented by Formula (I) below, wherein at least one terminal of the polymer is modified with at least one compound selected from the group consisting of a compound represented by Formula (II) below, a compound containing a group represented by Formula (III) below, a compound represented by Formula (IV) below, a silicon compound containing at least one of a group represented by Formula (V) below or a group represented by Formula (VI) below, and a compound containing a group represented by Formula (VII) below,
the rubber composition comprising the silica in an amount of 5 to 150 parts by mass relative to 100 parts by mass of the rubber component, and
the rubber composition comprising the silane coupling agent represented by Formula (1) in an amount of 2 to 20 parts by mass relative to 100 parts by mass of silica
(CpH2p+1O)3Si—CqH2q—S—CO—CkH2k+1  (1)wherein p represents an integer of 1 to 3; q represents an integer of 1 to 5; and k represents an integer of 5 to 12, andwherein Formulas (I) to (VII) are represented below:
wherein X1, X2, and X3 each independently represent a group represented by Formula (Ia) below, a hydroxy group, a hydrocarbyl group, or a substituted hydrocarbyl group, and at least one of X1, X2, and X3 is a hydroxy group or a group represented by the following Formula (Ia):wherein R1and R2each independently represent a C1-6 hydrocarbyl group, a C1-6 substituted hydrocarbyl group, a silyl group, or a substituted silyl group, and R1and R2may be bonded to each other to form a cyclic structure together with the nitrogen atom,wherein n represents an integer of 1 to 10; R11, R12, and R13each independently represent a C1-4 hydrocarbyl group or a C1-4 hydrocarbyloxy group, and at least one of R11 , R12, and R13 is a hydrocarbyloxy group; and A1 represents a nitrogen atom-containing functional group,wherein p represents an integer of 0 or 1; T represents a C1-20 hydrocarbylene group or a C1-20 substituted hydrocarbylene group; and A2 represents a nitrogen atom-containing functional group,wherein g represents an integer of 1 to 10; R21 represents a hydrogen atom, a C1-6 hydrocarbyl group, or a C1-6 substituted hydrocarbyl group; A3 represents an oxygen atom or the following group: —NR22— where R22 represents a hydrogen atom or a C1-10 hydrocarbyl group; and A4 represents a functional group containing at least one of a nitrogen atom or an oxygen atom,wherein w represents an integer of 1 to 11; and A5 represents a nitrogen atom-containing functional group.

US Pat. No. 10,189,985

POLYACRYLONITRILE (PAN) POLYMERS WITH LOW POLYDISPERSITY INDEX (PDI) AND CARBON FIBERS MADE THEREFROM

CYTEC INDUSTRIES INC., P...

1. A method for synthesizing a polyacrylonitrile (PAN) polymer with a narrow molecular weight distribution, the method comprising:a) combining acrylonitrile (AN) monomer with a solvent, at least one co-monomer, and a thiocarbonylthio compound to form a solution;
b) heating the solution to a temperature within the range of 40° C. 85° C.; and
c) adding an initiator to the heated solution to affect polymerization reaction, thereby forming a polymer solution comprising polyacrylonitrile (PAN) polymer,
wherein polymerization is affected by controlled/living radical polymerization, in which the thiocarbonylthio compound functions as a Reversible Addition/Fragmentation Chain Transfer (RAFT) agent,
wherein the thiocarbonylthio compound is selected from the following structures:

where Z1 is selected from:
—CH2—(CH2)10—CH3; —(CH2)n—CH3, n=0-20;
—C(CH3)m—COOH, m=1-2; —C(CH3)m—COOCH3, m=1-2;
—C(CH3)m—COOC2H5, m=1-2;
R1 is selected from:

R?1 is selected from: —CN;

x=0-1;
R?1 is selected from: H; —CH3; —(CH2)m—COOH, m=1-2;
R??1 is H or —CH3

where Z2 is selected from:

R is selected from: F, Cl, CN, OCH3;
R2 is selected from:

R?2 is selected from: —CN;

x=0-1;
—C(CH3)m—COOCH3, m=1-2;
—C(CH3)m—COOC2H5, m=1-2;
R?2 is selected from: H; —CH3; —(CH2)m—COOH, m=1-2;
R??2 is H or —CH3

where Z3 is selected from: —CH2—(CH2)10—CH3; —(CH2)y—CH3, y=1-20;
R3 is selected from: —CH2—(CH2)10—CH3; —(CH2)y—CH3, y=1-20,
wherein the PAN polymer has a polydispersity index (PDI) of about 2 or less and a molecular weight within the range of 60 kg/mole to 500 kg/mole.

US Pat. No. 10,189,977

PACK FOR ANAEROBIC PRODUCTS

1. A pack comprising:a. a container, the container having a container body; and
b. an anaerobically curable composition held within the container;wherein the container body is constructed from plastics material which is formed from a blend of a thermoplastic starch component, wherein the starch in the thermoplastic starch component is present in an amount from 6% to 33% of the weight of the blend used to form the container body and a polyethylene, and which is sufficiently oxygen permeable to prevent the anaerobically curable composition held therein from curing due to absence of oxygen.

US Pat. No. 10,189,965

PRODUCTION OF VISCOELASTIC POLYURETHANE SYSTEMS USING BLOCK POLYMERS HAVING BONDED SILOXANE BLOCKS AS CELL OPENERS

Evonik Degussa GmbH, Ess...

1. A method of producing a polyurethane foam, said method comprising:foaming a mixture to provide said polyurethane foam, said mixture comprising at least one isocyanate component, at least one polyol component, a blowing agent component comprising water and optionally a physical blowing agent, a stabilizer, and an additive comprising siloxane block polymers of the average general formula (I):
MaM1bDcD1dTeQfGg
with

G are radicals, same or different, selected from the group consisting of:
(O1/2?nSiRm—CH2CHR3—R2—CHR3CH2—SiRm?O1/2)n,
(01/2)n—SiRm—CH2CHR3—R2—CR3?CH2, and
(O1/2?nSiRm—CH2CHR3—R2—CR3?CR3—CH3,
a=1 to 8,
b=1 to 8,
c=3-450,
d=1-30,
e=0-20,
f=0-20,
g=0.15 to 2,
where a+b?2, a+b+c+d+e+f+g=N, and N is ?11 and ?500, and b+d?1,
R are radicals, same or different, having 1-16 carbon atoms or aryl radicals having 6-16 carbon atoms or H or —OR3,
R1 are polyether radicals having a formula (II)

wherein
R4 are alkyl radicals, same or different, which have from 1 to 18 carbon atoms, and optionally have ether functions, or aryl radicals which have from 6-18 carbon atoms and optionally have ether functions, or H,
R5 are radicals, same or different, wherein R5 is selected from the group consisting of: R3, H, and —C(O)R3,
h is from 2 to 18,
i is from 0 to 40,
j is from 1 to 40,
k is from 0 to 40,
l is from 0 to 30,
wherein i+j+k+l?3,
R2 are divalent organic radicals, same or different, which have 2-20 carbon atoms and are optionally interrupted by ether, ester or amide functions or (—SiR2O—)n groups and optionally bear OH functions,
R3 are alkyl radicals, same or different, having 1-16 carbon atoms or aryl radicals having 6-16 carbon atoms or H,
n=independently 1 or 2,
m=independently 1 or 2,
m+n=3,
wherein said at least one polyol component has an average hydroxyl number, determined to DIN 53240-1:2012-07, of greater than 56 to less than 450 mg KOH/g, and wherein said polyurethane foam is produced at an isocyanate index of 65 to 108 and has an open cell structure,
wherein said bonded siloxane block copolymers of the average general formula (I) are present in an amount of from 0.001 to 10 parts by weight per 100 parts of said at least one polyol component, and
wherein said at least one polyol component is present in an amount from 25% to 80% by weight of said mixture, water is present in an amount from 1% to 5% by weight of said mixture, catalysts are present in an amount from 0.01% to 1% by weight of said mixture, said physical blowing agent is present in an amount from 0% to 50% by weight of said mixture, said stabilizer is present in an amount of up to 5% by weight of said mixture, said at least one isocyanate component is present in an amount from 20% to 60% by weight of said mixture, and said additive is present in an amount from 0.001% to 10% by weight of said mixture.

US Pat. No. 10,189,960

RUBBER VIBRATION DAMPING MATERIAL

Dow Global Technologies L...

1. A vulcanized rubber comprised of polyisoprene uniformly crosslinked with a halogenated unsaturated polymer that is a reaction product of (i) an unsaturated polymer that is miscible with polyisoprene and has conjugated dienes that undergo a Diels Alder reaction and (ii) a polyhalogenated cyclopentadiene represented by:wherein X is a fluorine, chlorine or bromine and Y is fluorine, chlorine, bromine or alkoxy having 1 to 4 carbons.

US Pat. No. 10,189,956

POLYMER SUBSTRATES FORMED FROM CARBOXY FUNCTIONAL ACRYLAMIDE

LIFE TECHNOLOGIES AS, Os...

1. A compound of the formula:
wherein R1 is an alkyl group having between 3 and 10 carbons or is a polyether group having between 1 and 10 ether units, wherein R2 is a linear or branched alkyl group having between 3 and 8 carbons or a silyl group, and wherein R3 is hydrogen or an alkyl group having between 1 and 6 carbons.

US Pat. No. 10,189,953

TEMPERATURE-RESISTANT SILICONE RESINS

THE BOEING COMPANY, Chic...

1. A modified silicone resin of Formula (II):
wherein:
R6, R7, R8, R9, R10, and R11 are each independently selected from a group consisting of H, alkyl, alkenyl, alkynyl, and aryl;
X is selected from the group consisting of arylene, transition metal, cyclosiloxane, silsesquioxane;
t ranges from 1 to 10;
y ranges from 1 to 200; and
z ranges from 1 to 1,000, wherein the resin of Formula (II) has a viscosity ranging from about 500 cSt to about 10,000 cSt.

US Pat. No. 10,189,950

POLYIMIDE-BASED POLYMER THICK FILM COMPOSITIONS

E I DU PONT DE NEMOURS AN...

1. A polyimide-based polymer thick film composition comprising:(a) a non-fluorinated polyimide polymer with the structure I

wherein X is S(O)2 and Y is BAPP and;
(b) an organic solvent with the structure IV

wherein R1=CH3, R2=C(O)OCH3 and R3=H.

US Pat. No. 10,189,949

TRANSPARENT POLYIMIDE COPOLYMER, POLYIMIDE RESIN COMPOSITION AND MOLDED ARTICLE, AND PRODUCTION METHOD OF SAID COPOLYMER

SOMAR CORPORATION, Tokyo...

1. A transparent polyimide copolymer obtained by copolymerizing:(A) 4,4?-oxydiphthalic dianhydride; and
(B) at least one diamine and/or diisocyanate represented by the following Formulae (1) or (2):

(wherein, X represents an amino group or an isocyanate group; R1 to R4 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; and at least one of said R1 to R4 is not a hydrogen atom).

US Pat. No. 10,189,944

SURFACE MODIFICATION METHOD AND SURFACE-MODIFIED ELASTIC BODY

SUMITOMO RUBBER INDUSTRIE...

1. A method for producing a catheter of a rubber vulcanizate or a thermoplastic elastomer, the method comprising:step 1 of forming polymerization initiation points on a surface of the catheter; and
step 2 of radically polymerizing a deliquescent monomer starting from the polymerization initiation points by irradiation with ultraviolet light having a wavelength within the range of 300 to 400 nm, to grow polymer chains on the surface of the catheter,
wherein the deliquescent monomer is at least one selected from the group consisting of alkali metal salt of acrylic acid, alkali metal salt of methacrylic acid, alkali metal salt of itaconic acid, alkali metal salt of 3-vinylpropionic acid, alkali metal salt of 2-sulfoethyl (meth)acrylate, alkali metal salt of 3-sulfopropyl (meth)acrylate, alkali metal salt of 2-acrylamide-2-methylpropanesulfonic acid, and a compound represented by the following formula (1)

wherein R11 represents —H or —CH3; X represents —O—, —NH—, or —N+—; m denotes an integer of one or more; and Y represents a zwitterionic or halogen group.

US Pat. No. 10,189,942

POLYORGANOSILOXANE, POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER, AND PRODUCTION METHOD THEREFOR

IDEMITSU KOSAN CO., LTD.,...

1. A polycarbonate-polyorganosiloxane copolymer, comprising:a polycarbonate block (A) comprising a repeating unit represented by the following general formula (I); and
a polyorganosiloxane block (B) comprising a repeating unit represented by the following general formula (II),
wherein the polyorganosiloxane block (B) has a value obtained by integrating dw/d log(M) from 2.5?log(M)?3.1 is 0 to 10% of a value obtained by integrating dw/d log(M) over the entire range of log (M) in a differential molecular weight distribution curve,
wherein the differential molecular weight distribution curve is determined by gel permeation chromatography using the polystyrene calibration curve, has an x-axis showing a logarithmic value log(M) of a molecular weight M and has a y-axis showing dw/d log(M) obtained by differentiating a concentration fraction w with respect to the logarithmic value log(M) of the molecular weight:

wherein, R9 and R10 each independently represents a halogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms; X represents a single bond, an alkylene group having 1 to 8 carbon atoms, an alkylidene group having 2 to 8 carbon atoms, a cycloalkylene group having 5 to 15 carbon atoms, a cycloalkylidene group having 5 to 15 carbon atoms, a fluorenediyl group, an arylalkylene group having 7 to 15 carbon atoms, an arylalkylidene group having 7 to 15 carbon atoms, —S—, —SO—, —SO2—, —O—, or —CO—; a and b each independently represents an integer of 0 to 4; R1 and R2 each independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or an aryl group having 6 to 12 carbon atoms; an average repeat number n in the range of 30 to 50 represents a sum of siloxane repeating units in the polyorganosiloxane block.

US Pat. No. 10,189,939

HIGH PERFORMANCE EXTENDED POT LIFE EPOXY HARDENERS

ANGUS CHEMICAL COMPANY, ...

1. A method for curing an epoxy resin; said method comprising adding to the epoxy resin a curing agent comprising a compound of formula (I)
wherein:
X is a difunctional group selected from C3-C10 alkyl and C4-C20 heteroalkyl having only oxygen heteroatoms.

US Pat. No. 10,189,938

POLYUREA COMPOSITION

SIKA TECHNOLOGY AG, Baar...

1. A method comprising treating a substrate comprising an elastomeric material having unsaturated units with a curable composition, said treating selected from the group consisting of patching a defect in the substrate, coating the substrate, and adhesively bonding the substrate to another substrate, and said composition comprising at least, a first component and a second component, whereinthe first component K1 comprises
one or more than one di(aminobenzoate) ester A1 of formula (I)

with an average molecular weight of 500 g/mol to 2000 g/mol, where G is a divalent moiety deriving from poly(tetramethylene oxide) diol, and
the second component K2 comprises
one or more than one aromatic polyisocyanate B1 with an average molecular weight of 160 g/mol to 1100 g/mol, wherein the molar ratio between the isocyanate groups of the second component K2 and the isocyanate-reactive groups of the first component K1 is in the range from 1.3 to 1.0.

US Pat. No. 10,189,931

GRAFT POLYMER AND METHOD FOR PRODUCING SAME

NITTO BOSEKI CO., LTD., ...

1. A polyamine graft polymer obtained by polymerizing a polyamine derivative obtained by a reaction between (a) a polymer compound having at least one amino group and (b) a compound having at least one epoxy group; and (c) an ethylenically unsaturated monomer,wherein the polymer compound having at least one amino group (a) is selected from the group consisting of an ethyleneimine (co)polymer having a structure represented by general formula (1), a vinylamine (co)polymer having a structure represented by general formula (2), an allylamine (co)polymer having a structure represented by general formula (3), a diallylamine (co)polymer having a structure represented by general formula (4), and an acrylic amine (co)polymer having a structure represented by general formula (5) (in the following general formulae, n is an integer of from 10 to 200000, m is an integer of from 5 to 18000, 1 is an integer of from 5 to 15000, o is an integer of from 10 to 10000, and p is an integer of from 1 to 100)

and wherein the ethylenically unsaturated monomer (c) is selected from the group consisting of a vinyl monomer, a styrene monomer, a methacrylate monomer, an acrylate monomer, an acrylamide monomer, an allyl monomer, a diallyl monomer, and an unsaturated carboxylic acid.

US Pat. No. 10,189,930

POLYMERIC PHOTOINITIATORS

ALLNEX BELGIUM S.A., Dro...

1. A radiation curable composition (A) comprising,(a) at least one photoinitiator compound of formula (I):

wherein Q is the residue of a hydroxy compound having 1 to 6 hydroxyl groups,
wherein x is a number that is at least 1 but no greater than the number of hydroxyl groups originally present in said hydroxy compound, and
wherein the hydroxy compound is a saturated hydroxy compound having 1 to 6 hydroxyl groups and is selected from the group consisting of an alkoxylated alcohol and a polyether; and
(b) at least one ethylenically unsaturated compound selected from the group consisting of monomers (b1) and oligomers (b2).

US Pat. No. 10,189,929

ACTIVE-ENERGY-RAY-CURABLE COMPOSITION FOR OPTICAL MEMBERS, CURED ARTICLE, AND OPTICAL LENS AND SHEET OR FILM FOR OPTICAL LENSES EACH PRODUCED USING SAID CURED ARTICLE

SANYO CHEMICAL INDUSTRIES...

1. An active energy ray-curable composition for optical components, wherein the composition is composition (I) or composition (II),the composition (I) comprising:
a monomer (A) having 2 or more radical-polymerizable reactive groups (x1), wherein the homopolymer of the monomer (A) has a glass transition temperature of higher than 200° C.;
a monomer (B) having 2 or more radical-polymerizable reactive groups (x3), wherein the homopolymer of the monomer (B) has a glass transition temperature of ?15° C. or higher and 100° C. or lower, wherein the monomer (B) comprises a (meth)acrylate having 2 to 6 radical-polymerizable reactive groups (x3) and in a molecule, 1 to 15 organic groups (b) represented by the following formula (5):

wherein p represents 4 or 5;
a monomer (C) having 2 or more radical-polymerizable reactive groups (x2), wherein the homopolymer of the monomer (C) has a glass transition temperature of lower than ?15° C., wherein the monomer (C) comprises a polyfunctional (meth)acrylate represented by the following formula (1):
wherein X represents a hydroxyl group, a methyl group, a (meth)acryloyloxy group, a group represented by the formula (2), or a group represented by the formula (3):R1 to R3 and R each represent a hydrogen atom or a methyl group and may be the same as or different from one another, Y1 to Y5 each represent a C2-C4 oxyalkylene group and may be the same as or different from one another, and a, b, c, d, and e independently represent an integer of 0 to 10, provided that a+b+c+d+e is 6 to 40, and/ora bifunctional (meth)acrylate represented by the following formula (4):wherein R4 and R5 independently represent a hydrogen atom or a methyl group, and m and n independently represent an integer of 3 to 10;a slip agent (D); and
a photopolymerization initiator (E), wherein the photopolymerization initiator (E) comprises a phosphine oxide compound (E1) and/or a hydroxy benzoyl compound (E5),
wherein the radical-polymerizable reactive groups (x1), (x2) and (x3) are each at least one group selected from the group consisting of an acrylate group and a methacrylate group,
wherein the composition contains 41% to 59% by weight of the monomer (A) and 41% to 59% by weight of the monomer (C) based on the total weight of the monomers (A) and (C),
15% to 20% by weight of the monomer (B) based on the total weight of the monomers (A), (B), and (C),
0.8 to 5% by weight of the slip agent (D) based on the total weight of the monomers (A) and (C), and
1 to 8% by weight of the photopolymerization initiator (E) based on the total weight of the monomers (A) and (C); and
the composition (II) comprising:
a monomer (A) having 2 or more radical-polymerizable reactive groups (x1), wherein the homopolymer of the monomer (A) has a glass transition temperature of higher than 200° C.;
a monomer (C) having 2 or more radical-polymerizable reactive groups (x2), wherein the homopolymer of the monomer (C) has a glass transition temperature of lower than ?15° C., wherein the monomer (C) comprises a polyfunctional (meth)acrylate represented by the above formula (1) and a bifunctional (meth)acrylate represented by the above formula (4); and
a slip agent (D); and
a photopolymerization initiator (E), wherein the photopolymerization initiator (E) comprises a phosphine oxide compound (E1) and/or a hydroxy benzoyl compound (E5),
wherein the radical-polymerizable reactive groups (x1) and (x2) are each at least one group selected from the group consisting of an acrylate group and a methacrylate group,
wherein the composition contains 9% to 40% by weight of the monomer (A) and 60 to 91% by weight of the monomer (C) based on the total weight of the monomers (A) and (C),
20% to 60% by weight of the polyfunctional (meth)acrylate represented by the above formula (1) and 30% to 55% by weight of the bifunctional (meth)acrylate represented by the above formula (4) based on the total weight of the monomers (A) and (C),
0.8 to 5% by weight of the slip agent (D) based on the total weight of the monomers (A) and (C), and
1 to 8% by weight of the photopolymerization initiator (E) based on the total weight of the monomers (A) and (C).

US Pat. No. 10,189,927

IONOMER HAVING HIGH OXYGEN PERMEABILITY

DAIKIN INDUSTRIES, LTD., ...

1. An ionomer, comprising:a repeating unit A;
a repeating unit B, and
a repeating unit C,
the ionomer having an equivalent weight of 250 to 930 and a glass transition temperature of 100° C. to 130° C.,
the amount of the repeating unit B is 16 to 45 mol %, relative to all the repeating units,
the repeating unit B being represented by the formula (2):
wherein Rp represents a monovalent group having a proton exchange group,wherein the repeating unit A is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (3):
wherein m3 represents an integer of 2 to 6; anda repeating unit represented by the formula (4):
wherein Y41 represents F or a C1-C3 perfluoroalkyl group; k4 represents 0 or 1; n4 represents an integer of 1 to 8; when n4 represents an integer of 2 to 8, Y41 in each of respective units —(CF2CFY41—O)n4— may be the same as or different from each other; and m4 represents an integer of 1 to 6,wherein the repeating unit C that is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (7):
wherein Rf71 represents F, Cl, or a C1-C9 linear or branched fluoroalkyl group, anda repeating unit represented by the formula (8):
wherein Y81 represents H or F; Y82 represents F or a C1-C9 linear or branched fluoroalkyl group;and Y83 represents H, F, Cl, or a C1-C9 linear or branched fluoroalkyl group.

US Pat. No. 10,189,925

RAPID CURE POLYMERIC RESINS

THE BOEING COMPANY, Chic...

1. A polymer of formula (I):
wherein:
each instance of R1 is —C1-5—O—C1-5—O—C1-5—;
each instance of R2 is the same or different and is selected from

 each instance of R24 is independently selected from hydrogen, alkyl, or alkoxy;
“Linker” is of formula (II):

c is less than 1.0;
d is 0 when c is 0; and
a+b+d is from about 7 to about 38.

US Pat. No. 10,189,923

PRODUCING POLYOLEFIN PRODUCTS

Univation Technologies, L...

1. A method of polymerizing olefins within a polymerization reactor to produce a polyolefin polymer with a multimodal composition distribution, comprising contacting ethylene and a comonomer with a catalyst system, wherein the catalyst system comprises a first catalyst compound and a second catalyst compound that are co-supported to form a commonly supported catalyst system, wherein the first catalyst compound comprises the following formula:(C5HaR1b)(C5HcR2d)HfX2
wherein each R1 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; each R2 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; a and c are ?3; a+b=c+d=5; at least one R1 and at least one R2 is a hydrocarbyl or substituted hydrocarbyl group; adjacent groups R1 and R2 groups are optionally coupled to form a ring; and each X is independently a leaving group selected from a labile hydrocarbyl, substituted hydrocarbyl, or heteroatom group, or a divalent radical that links to an R1 or R2 group; and the second catalyst compound comprises the following formula:

wherein each R3 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; R4 is a hydrocarbyl group, a substituted hydrocarbyl group, or a heteoatom group; each R5 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; wherein R3, R4, and R5 are the same or different; and each X is independently a leaving group selected from a labile hydrocarbyl, a substituted hydrocarbyl, a heteroatom group, or a divalent radical that links to an R3, R4, or R5 group.

US Pat. No. 10,189,921

RADICAL POLYMERISATION OF ETHYLENE INITIATED BY A COUPLE OF ORGANIC PEROXIDES WITH HIGH PRODUCTIVITY

ARKEMA FRANCE, Colombes ...

1. A process for manufacturing polyethylene or an ethylene copolymer, comprising radical polymerization or copolymerization of ethylene in the presence:of a first peroxide polymerization initiator chosen from the diperketal peroxide compounds of formula:

wherein the R1, R2, R3, R6, R7 and R8 groups comprise substituted or unsubstituted, linear, branched or cyclic C1-C10 alkyl groups, and
of a second initiator, other than said first initiator, also comprising a diperketal peroxide of formula (I).

US Pat. No. 10,189,920

HYBRID SUPPORTED CATALYST SYSTEM AND METHOD OF PREPARING POLYOLEFIN USING THE SAME

LG Chem, Ltd., Seoul (KR...

1. A hybrid supported catalyst system comprising;one or more organic chromium compounds and one or more metallocene compounds supported on a support,
wherein the organic chromium compound includes two or more of a group represented by the following Chemical Formula 1 in a molecule, phosphorous atoms (P) in one or more of the group represented by Chemical Formula 1 form a coordinate bond with chromium (Cr), and a linkage group (L) linking the two or more groups represented by the following Chemical Formula 1 via 4 to 8 carbon atoms is an aliphatic group having 2 to 20 carbon atoms, a heteroaliphatic group having 2 to 20 carbon atoms, an alicyclic group having 2 to 20 carbon atoms, a heteroalicyclic group having 2 to 20 carbon atoms, or a group prepared by linking two or more of the aliphatic group, the heteroaliphatic group, the alicyclic group, and the heteroalicyclic group:

wherein * is a part which binds to the linkage group (L) linking the two or more groups, and
R1 to R4 are each independently an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, or an alkoxyaryl group having 7 to 20 carbon atoms.

US Pat. No. 10,189,916

TRANSITION METAL COMPOUND AND CATALYST COMPOSITION INCLUDING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A transition metal compound of the following Chemical Formula 1:
wherein, in Chemical Formula 1,
M is a group 4 transition metal;
R is selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, and an alkylaryl group having 7 to 20 carbon atoms; or R and R1 are linked to each other to form an aliphatic ring having 3 to 20 carbon atoms or an aromatic ring having 5 to 20 carbon atoms including N;
R1 to R10 are each independently selected from the group consisting of a hydrogen atom, a halogen group, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, a silyl group and combinations thereof, or two or more adjacent functional groups among R1 to R10 are linked to each other to form an aliphatic ring having 3 to 20 carbon atoms or an aromatic ring having 6 to 20 carbon atoms;
R11 is selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, a silyl group, and a metalloid radical of a group 14 metal substituted with a hydrocarbyl group having 1 to 20 carbon atoms;
X1 and X2 are each independently selected from the group consisting of a halogen group, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylamino group having 1 to 20 carbon atoms, an arylamino group having 6 to 20 carbon atoms and an alkylidene group having 1 to 20 carbon atoms;
R, R1 to R11, X1 and X2 are each independently unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen group, an alkyl group having 1 to 20 carbon atoms, a haloalkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms and an aryloxy group having 6 to 20 carbon atoms;
n is an integer of 1 or 2, and when n is an integer of 2, R11's are the same as or different from each other; and
wherein a dashed line to the cyclopentadienyl ring represents an ?5-complex with the cyclopentadienyl ring, and a solid line to the cyclopentadienyl ring represents a ?-bond to a carbon of the cyclopentadienyl ring.

US Pat. No. 10,189,913

BIOPOLYMERS HAVING COILED NANOSTRUCTURES AND PROCESSES INCORPORATING THE BIOPOLYMERS

BIOPOLYNET INC., Frederi...

1. A process for preparing iron ore pellets comprising:combining crushed iron ore with bentonite and a first aqueous solution, the first aqueous solution having a first binder comprising one or more first biopolymers having coiled nanostructures to form a mixture;
shaping the mixture into a pellet; and
spraying the pellet with a second aqueous solution, the second aqueous solution containing at least one second biopolymer having a coiled nanostructure that is configured to react with an agent in the first aqueous solution to cause the one or more first biopolymers to undergo cross-linking to form a biopolymeric network in order to prepare a green ball.

US Pat. No. 10,189,894

RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR

Adimab, LLC, Lebanon, NH...

1. An antibody isolated from a library comprising synthetic polynucleotides that encode an antibody heavy chain and an antibody light chain containing at least about 106 unique antibody CDRH3 amino acid sequences, wherein each of the polynucleotides encoding the at least about 106 unique antibody CDRH3 amino acid sequences has an antibody CDRH3 amino acid sequence represented by the following formula:[X]-[N1]-[DH]-[N2]-[H3-JH], wherein
(i) X is selected from the group consisting of G, D, E and nothing;
(ii) N1 is an amino acid sequence selected from the group consisting of G, P, R, A, S, L, T, V, GG, GP, GR, GA, GS, GL, GT, GV, PG, RG, AG, SG, LG, TG, VG, PP, PR, PA, PS, PL, PT, PV, RP, AP, SP, LP, TP, VP, IG, KG, GW, FP, EG, GGG, GPG, GRG, GAG, GSG, GLG, GTG, GVG, PGG, RGG, AGG, SGG, LGG, TGG, VGG, GGP, GGR, GGA, GGS, GGL, GGT, GGV, D, E, F, H, I, K, M, Q, W, Y, AR, AS, AT, AY, DL, DT, EA, EK, FH, FS, HL, HW, IS, KV, LD, LE, LR, LS, LT, NR, NT, QE, QL, QT, RA, RD, RE, RF, RH, RL, RR, RS, RV, SA, SD, SE, SF, SI, SK, SL, SQ, SR, SS, ST, SV, TA, TR, TS, TT, TW, VD, VS, WS, YS, AAE, AYH, DTL, EKR, ISR, NTP, PKS, PRP, PTA, PTQ, REL, RPL, SAA, SAL, SGL, SSE, TGL, WGT;
(iii) DH is all of a human CDRH3 DH amino acid sequence, wherein the DH amino acid sequence is selected from the group consisting of ATT, GAT, GIV, IVG, VGA, VLLLWLLL (SEQ ID NO: 239), ITMIVVVIT (SEQ ID NO: 240), VQWLV (SEQ ID NO: 241), VQQLV (SEQ ID NO: 242), VLRFLEWLLY (SEQ ID NO: 243), YYDFWSGYYT (SEQ ID NO: 244), WILYQLLC (SEQ ID NO: 245), LRL (SEQ ID NO: 246), TTVT (SEQ ID NO: 247), VWELL (SEQ ID NO: 248), VDTAMVT (SEQ ID NO: 249), WIQLWL (SEQ ID NO: 250), RILWWLLL (SEQ ID NO: 251), DIVVVVAAT (SEQ ID NO: 252), VLLLWFG (SEQ ID NO: 595), GATT (SEQ ID NO: 623), GIVG (SEQ ID NO: 624), IVGA (SEQ ID NO: 625), VGAT (SEQ ID NO: 626), GIVGA (SEQ ID NO: 627), IVGAT (SEQ ID NO: 628), VGATT (SEQ ID NO: 629), GIVGAT (SEQ ID NO: 630), IVGATT (SEQ ID NO: 631), GIVGATT (SEQ ID NO: 13), YSG, YSGS (SEQ ID NO: 632), YSGSY (SEQ ID NO: 633), YSGSYY (SEQ ID NO: 14), CSSTSC (SEQ ID NO: 622), CSSTSCY (SEQ ID NO: 620), YCSSTSC (SEQ ID NO: 621), CSSTSCYT (SEQ ID NO: 617), GYCSSTSC (SEQ ID NO: 618), YCSSTSCY (SEQ ID NO: 619), GYCSSTSCY (SEQ ID NO: 615), YCSSTSCYT (SEQ ID NO: 616), GYCSSTSCYT (SEQ ID NO:10), AAM, DIV, IVY, PAA, VPA, VVP, VVV, DIVV (SEQ ID NO: 634), IVVV (SEQ ID NO: 635), PAAM (SEQ ID NO: 636), VPAA (SEQ ID NO: 637, VVPA (SEQ ID NO: 638), VVVP (SEQ ID NO: 639), DIVVY (SEQ ID NO: 640), IVVVP (SEQ ID NO: 641), VPAAM (SEQ ID NO: 642), VVPAA (SEQ ID NO: 643), VVVPA (SEQ ID NO: 644), DIVVVP (SEQ ID NO: 645), IVVVPA (SEQ ID NO: 646), VVPAAM (SEQ ID NO: 647), VVVPAA (SEQ ID NO: 648), DIVVVPA (SEQ ID NO: 649), IVVVPAA (SEQ ID NO: 650), VVVPAAM (SEQ ID NO: 651), DIVVVPAA (SEQ ID NO: 652), IVVVPAAM (SEQ ID NO: 653), DIVVVPAAM (SEQ ID NO: 11), CSGGSC (SEQ ID NO: 654), CSGGSCY (SEQ ID NO: 655), YCSGGSC (SEQ ID NO: 656), CSGGSCYS (SEQ ID NO: 657), GYCSGGSC (SEQ ID NO: 658), YCSGGSCY (SEQ ID NO: 659), GYCSGGSCY (SEQ ID NO: 660), YCSGGSCYS (SEQ ID NO: 661), GYCSGGSCYS (SEQ ID NO: 16), FGV, GVV, IFG, ITI, TIF, VVI, FGVV (SEQ ID NO: 662) , GVVI (SEQ ID NO: 663), IFGV (SEQ ID NO: 664), ITIF (SEQ ID NO: 665) , TIFG (SEQ ID NO: 666), VVII (SEQ ID NO: 667), FGVVI (SEQ ID NO: 668), GVVII (SEQ ID NO: 669), IFGVV (SEQ ID NO: 670), ITIFG (SEQ ID NO: 671), TIFGV (SEQ ID NO: 672), FGVVII (SEQ ID NO: 673), IFGVVI (SEQ ID NO: 674), ITIFGV (SEQ ID NO: 675), TIFGVV(SEQ ID NO: 676), IFGVVII (SEQ ID NO: 677), ITIFGVV (SEQ ID NO: 678), TIFGVVI (SEQ ID NO: 679), ITIFGVVI (SEQ ID NO: 680), TIFGVVII(SEQ ID NO: 681), ITIFGVVII (SEQ ID NO: 9), ELL, FGE, GEL, LLW, LWF, VLL, WFG, FGEL (SEQ ID NO: 682), GELL (SEQ ID NO: 683), LLWF (SEQ ID NO: 684), LWFG (SEQ ID NO: 685), VLLW (SEQ ID NO: 686), WFGE (SEQ ID NO: 687), FGELL (SEQ ID NO: 688), LLWFG (SEQ ID NO: 689), LWFGE (SEQ ID NO: 690), VLLWF (SEQ ID NO: 691), WFGEL (SEQ ID NO: 692), LLWFGE (SEQ ID NO: 693), LWFGEL (SEQ ID NO: 694), VLLWFG (SEQ ID NO: 695), WFGELL (SEQ ID NO: 696), LLWFGEL (SEQ ID NO: 697), LWFGELL (SEQ ID NO: 698), VLLWFGE (SEQ ID NO: 699), LLWFGELL (SEQ ID NO: 700), VLLWFGEL (SEQ ID NO: 701), VLLWFGELL (SEQ ID NO: 1), GSG, GSY, SGS, SYY, YGS, YYG, YYN, YYY, GSGS (SEQ ID NO: 702), GSYY (SEQ ID NO: 703), SGSY (SEQ ID NO: 704) , SYYN (SEQ ID NO: 705), YGSG (SEQ ID NO: 706), YYGS (SEQ ID NO: 707), YYYG (SEQ ID NO: 708), GSGSY (SEQ ID NO: 709), GSYYN (SEQ ID NO: 710), SGSYY (SEQ ID NO: 711), YGSGS (SEQ ID NO: 712), YYGSG (SEQ ID NO: 713), YYYGS (SEQ ID NO: 714), GSGSYY (SEQ ID NO: 715), SGSYYN (SEQ ID NO: 716), YGSGSY (SEQ ID NO: 717), YYGSGS (SEQ ID NO: 718), YYYGSG (SEQ ID NO: 719), GSGSYYN (SEQ ID NO: 720), YGSGSYY (SEQ ID NO: 721), YYGSGSY (SEQ ID NO: 722), YYYGSGS (SEQ ID NO: 723), YGSGSYYN (SEQ ID NO: 724), YYGSGSYY (SEQ ID NO: 725), YYYGSGSY (SEQ ID NO: 726), YYGSGSYYN (SEQ ID NO: 727), YYYGSGSYY (SEQ ID NO: 728), YYYGSGSYYN (SEQ ID NO: 2), GVI, ITM, MVR, RGV, TMV, VII, VRG, GVII (SEQ ID NO: 729), ITMV (SEQ ID NO: 730), MVRG (SEQ ID NO: 731), RGVI (SEQ ID NO: 732), TMVR (SEQ ID NO: 733), VRGV (SEQ ID NO: 734), ITMVR (SEQ ID NO: 735), MVRGV (SEQ ID NO: 736), RGVII (SEQ ID NO: 737), TMVRG (SEQ ID NO: 738), VRGVI (SEQ ID NO: 739), ITMVRG (SEQ ID NO: 740), MVRGVI (SEQ ID NO: 741), TMVRGV (SEQ ID NO: 742), VRGVII (SEQ ID NO: 743), ITMVRGV (SEQ ID NO: 744), MVRGVII (SEQ ID NO: 745), TMVRGVI (SEQ ID NO: 746), ITMVRGVI (SEQ ID NO: 747), TMVRGVII (SEQ ID NO: 748), ITMVRGVII (SEQ ID NO: 3), DSS, GYY, SGY, SSG, YDS, YYD, DSSG (SEQ ID NO: 749), GYYY (SEQ ID NO: 750), SGYY (SEQ ID NO: 751), SSGY (SEQ ID NO: 752), YDSS (SEQ ID NO: 753), YYDS (SEQ ID NO: 754), YYYD (SEQ ID NO: 755), DSSGY (SEQ ID NO: 756), SGYYY (SEQ ID NO: 757), SSGYY (SEQ ID NO: 758), YDSSG (SEQ ID NO: 759), YYDSS (SEQ ID NO: 760), YYYDS (SEQ ID NO: 761), DSSGYY (SEQ ID NO: 762), SSGYYY (SEQ ID NO: 763, YDSSGY (SEQ ID NO: 764), YYDSSG (SEQ ID NO: 765), YYYDSS (SEQ ID NO: 766), DSSGYYY (SEQ ID NO: 767), YDSSGYY (SEQ ID NO: 768), YYDSSGY (SEQ ID NO: 769), YYYDSSG (SEQ ID NO: 770), YDSSGYYY (SEQ ID NO: 771), YYDSSGYY (SEQ ID NO: 772), YYYDSSGY (SEQ ID NO: 773), YYDSSGYYY (SEQ ID NO: 774), YYYDSSGYY (SEQ ID NO: 775), YYYDSSGYYY (SEQ ID NO: 4), DYG, GDY, YGD, DYGD (SEQ ID NO: 613), YGDY (SEQ ID NO: 614), DYGDY (SEQ ID NO: 12), SYG, YGY, YSY, GYSY (SEQ ID NO: 776), SYGY (SEQ ID NO: 777), YSYG (SEQ ID NO: 778), GYSYG (SEQ ID NO: 779), YSYGY (SEQ ID NO: 780), GYSYGY (SEQ ID NO: 15), SSS, SSW, SWY, SSSW (SEQ ID NO: 781), SSWY (SEQ ID NO: 782), YSSS (SEQ ID NO: 783), GYSSS (SEQ ID NO: 784), SSSWY (SEQ ID NO: 785), YSSSW(SEQ ID NO: 786), GYSSSW (SEQ ID NO: 787), YSSSWY (SEQ ID NO: 788), GYSSSWY (SEQ ID NO: 7) , GWY, GYS, SGW, YSS, GYSS (SEQ ID NO: 789), SGWY (SEQ ID NO: 790), SSGW (SEQ ID NO: 791), YSSG (SEQ ID NO: 792), GYSSG (SEQ ID NO: 793), SSGWY (SEQ ID NO: 794), YSSGW (SEQ ID NO: 795), GYSSGW (SEQ ID NO: 796), YSSGWY (SEQ ID NO: 797), GYSSGWY (SEQ ID NO: 5), AVA, GIA, IAV, VAG, AVAG (SEQ ID NO: 798), GIAV (SEQ ID NO: 799), IAVA (SEQ ID NO: 800), GIAVA (SEQ ID NO: 801), IAVAG (SEQ ID NO: 802), GIAVAG (SEQ ID NO: 6), AAA, AAG, IAA, AAAG (SEQ ID NO: 803), GIAA (SEQ ID NO: 804), IAAA (SEQ ID NO: 805), GIAAA (SEQ ID NO: 806), IAAAG (SEQ ID NO: 807), and GIAAAG (SEQ ID NO: 8);
(iv) N2 is an amino acid sequence selected from the group consisting of G, P, R, A, S, L, T, V, GG, GP, GR, GA, GS, GL, GT, GV, PG, RG, AG, SG, LG, TG, VG, PP, PR, PA, PS, PL, PT, PV, RP, AP, SP, LP, TP, VP, IG, KG, GW, FP, EG, GGG, GPG, GRG, GAG, GSG, GLG, GTG, GVG, PGG, RGG, AGG, SGG, LGG, TGG, VGG, GGP, GGR, GGA, GGS, GGL, GGT, GGV, D, E, F, H, I, K, M, Q, W, Y, AR, AS, AT, AY, DL, DT, EA, EK, FH, FS, HL, HW, IS, KV, LD, LE, LR, LS, LT, NR, NT, QE, QL, QT, RA, RD, RE, RF, RH, RL, RR, RS, RV, SA, SD, SE, SF, SI, SK, SL, SQ, SR, SS, ST, SV, TA, TR, TS, TT, TW, VD, VS, WS, YS, AAE, AYH, DTL, EKR, ISR, NTP, PKS, PRP, PTA, PTQ, REL, RPL, SAA, SAL, SGL, SSE, TGL, WGT;
(v) H3-JH is all of a human CDRH3 H3-JH amino acid sequence, wherein the H3-JH amino acid sequence is selected from the group consisting of AEYFQH (SEQ ID NO: 17), EYFQH (SEQ ID NO: 583), YFQH (SEQ ID NO: 584), FQH, QH, H YWYFDL (SEQ ID NO: 18), WYFDL (SEQ ID NO: 585), YFDL (SEQ ID NO: 586), FDL, DL, L, AFDV (SEQ ID NO: 19), FDV, DV, V, YFDY (SEQ ID NO: 20), FDY, DY, Y, NWFDS (SEQ ID NO: 21), WFDS (SEQ ID NO: 587), FDS, DS, S, YYYYYGMDV (SEQ ID NO: 22), YYYYGMDV (SEQ ID NO: 588), YYYGMDV (SEQ ID NO: 589), YYGMDV (SEQ ID NO: 590), YGMDV (SEQ ID NO: 591), GMDV (SEQ ID NO: 592), MDV, AFDI (SEQ ID NO: 852), FDI, DI, NWFDP (SEQ ID NO: 857), WFDP (SEQ ID NO: 858), FDP, and DP;
wherein the diversity of the polynucleotides encoding the at least about 106 unique antibody CDRH3 amino acid sequences is created by each of the polynucleotides having a CDRH3 sequence that is different from the CDRH3 sequence of every other polynucleotide;
wherein the antibody heavy chain is a variable domain with framework (FRM) and complementary determining regions (CDR) comprising FRMH1-CDRH1-FRM2-CDRH2-FRMH3-CDRH3-FRMH4; and
a VKCDR3 amino acid sequence comprising about 1 to about 10 of the amino acids found at Kabat positions 89, 90, 91, 92, 93, 94, 95, 95A, 96, and 97, in selected VKCDR3 amino acid sequences derived from a particular IGKV or IGKJ germline sequence;
wherein the antibody light chain is a variable domain with framework (FRM) and complementary determining regions (CDR) comprising FRMVK1-VKCDR1-FRMVK2-VKCDR2-FRMVK3-VKCDR3-FRMVK4.

US Pat. No. 10,189,873

COMPOSITIONS AND METHODS FOR INHIBITING “STIMULATOR OF INTERFERON GENE”-DEPENDENT SIGNALLING

ADURO BIOTECH, INC., Ber...

1. A compound having the structure:
covalently linked to
whereinR3 is a covalent bond to the 5? carbon of (b),
R4 is a covalent bond to the 3? carbon of (b),
R1 is a purine-derived substituent linked through its N9 nitrogen to the ribose ring of (a),
R5 is a purine-derived substituent linked through its N9 nitrogen to the ribose ring of (b),
each of X1 and X2 are independently O or S,
R2 is H or an optionally substituted alkynyl of from 2-9 carbons, wherein substitution(s), when present, may be independently selected from the group consisting of C1-6 alkyl straight or branched chain, benzyl, halogen, trihalomethyl, C1-6 alkoxy, —NO2, —NH2, —OH, ?O, —COOR? where R? is H or lower alkyl, —CH2OH, and —CONH2,
the 2? carbon of (b) is substituted with —O—R6, wherein R6 is H or an optionally substituted alkynyl of from 2-9 carbons, wherein substitution(s), when present, may be independently selected from the group consisting of C1-6 alkyl straight or branched chain, benzyl, halogen, trihalomethyl, C1-6 alkoxy, —NO2, —NH2, —OH, ?O, —COOR? where R? is H or lower alkyl, —CH2OH, and —CONH2, and
wherein R2 and R6 are not both H,
or pharmaceutically acceptable salts thereof.

US Pat. No. 10,189,872

CRYSTALLINE FORM OF NICOTINAMIDE RIBOSIDE

1. A crystalline Form II of nicotinamide riboside chloride

US Pat. No. 10,189,869

AMINO COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS

Achillion Pharmaceuticals...

1. A method for the treatment of a disorder mediated by complement D selected from paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and C3 glomerulonephritis comprising administering an effective amount to a human in need thereof of a compound of Formula I,or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, wherein:Q1 is C(R1R1?);
Q2 is C(R2R2?);
Q3 is C(R3R3?);
X1 isle;
X2 is CH;
R1, R1?, R2, R2?, R3, and R3? are independently chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C2-C6alkynyl, C2-C6alkanoyl, C1-C6thioalkyl, hydroxyC1-C6alkyl, aminoC1-C6alkyl, —C0-C4alkylR9R10, —C(O)OR9, —OC(O)R9, —NR9C(O)R10, —C(O)NR9R10, —OC(O)NR9R10, —NR9C(O)OR10, C1-C2haloalkyl, and C1-C2haloalkoxy,
or R1 and R2 form a 3- to 6-membered carbocyclic or aryl ring;
or R2 and R3 form a 3- to 6-membered carbocyclic ring;
or R1 and R1?, or R2 and R2?, or R3 and R3? form a 3- to 6-membered carbocyclic Spiro ring;
or R2 and R2? or R3 and R3? form a 3- to 6-membered heterocyclic spiro ring;
each of which ring is unsubstituted or substituted with 1 or more substituents independently, chosen from halogen, hydroxyl, cyano, —COOH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, hydroxyC1-C4alkyl, (mono- and di-C1-C4alkylamino)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), —O—C0-C4alkyl(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
or R1 and R1?, R2 and R2?, or R3 and R3? form a carbonyl group;
or R1 and R2 or R2 and R3 form a carbon-carbon double bond;
R9 and are independently chosen at each occurrence from hydrogen, C1-C6alkyl, (C3-C7cycloalkyl)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), and —O—C0-C4alkyl(C3-C7cycloalkyl);
A is a group selected from:

R5 and R6 are independently selected from CHO, —C(O)NH2, —C(O)NH(CH3), C2-C6alkanoyl, hydrogen, hydroxyl, halogen, cyano, nitro, —COOH, —SO2NH2, vinyl, C1-C6alkyl (including methyl), C2-C6alkenyl, C1-C6alkoxy, —C0-C4alkyl(C3-C7cycloalkyl), —C(O)C0-C4alkyl(C3-C7cycloalkyl), —P(O)(OR9)2, —OC(O)R9, —C(O)OR9, —C(O)N(CH2CH2R9)(R10), —NR9C(O)R10, phenyl, or 5- to 6-membered heteroaryl; and wherein each R5 and R6 other than hydrogen, hydroxyl, cyano, and COOH is unsubstituted or optionally substituted;
R8 and R8? are hydrogen;
X11 is N or CR11;
X12 is N or CR12;
X13 is N or CR13;
X14 is N or CR14, and wherein no more than two of X11, X12, X13, and X14 are N;
one of R12 and R13 is chosen from R31 and the other of R12 and R13 is chosen from R32;
R31 is chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, —COOH, C1-C2haloalkyl, C1-C2haloalkoxy, —C0-C4alkyl(C3-C7cycloalkyl), C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, C2-C6alkenyloxy, —C(O)OR9, C1-C6thioalkyl, —C0-C4alkylNR9R10, —C(O)NR9R10, —SO2R9, —SO2NR9R10, —OC(O)R9, and —C(NR9)NR9R10, each of which R31 other than hydrogen, halogen, hydroxyl, nitro, cyano, C1-C2haloalkyl, and C1-C2haloalkoxy is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, amino, —COON, —CONH2, C1-C2haloalkyl, and C1-C2haloalkoxy, and each of which R31 is also optionally substituted with one substituent chosen from phenyl and 4- to 7-membered heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S; which phenyl or 4- to 7-membered heterocycle is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl)(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
R32 is NR37R38, NR9SO2R38, or N(SO2R9)CH2C(O)R39;
R11, R14, and R15 are independently chosen at each occurrence from hydrogen, halogen, hydroxyl, nitro, cyano, —O(PO)(OR9)2, —(PO)(OR9)2; C2-C6alkenyl, C2-C6alkynyl, C2-C6alkanoyl, C1-C6alkoxy, C1-C6thioalkyl, —C0-C4alkyl(mono- and di-C1-C6alkylamino), —C0-C4alkyl(C3-C7cycloalkyl), —C0-C4alkoxy(C3-C7cycloalkyl), C1-C2haloalkyl and C1-C2haloalkoxy;
R37 is aryl, heteroaryl, heterocycle, (aryl)C0-C4alkyl, (heterocycle)C0-C4alkyl, (heteroaryl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, —S(O)(O)(alkyl), —S(O)(alkyl), —S(O)(O)(heteroalkyl), —S(O)(heteroalkyl), —S(O)(O)(aryl), —S(O)(aryl), —S(O)(O)(heteroaryl), —S(O)(heteroaryl);
R38 is hydrogen, hydroxyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, or —C1-C4alkylC(O)OC1-C6alkyl;
R21 and R22 are independently chosen at each occurrence from hydrogen, hydroxyl, cyano, amino, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy; (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R21 and R22 can be optionally substituted;
R23 is independently chosen at each occurrence from C1-C6alkyl, C1-C6haloalkyl, (aryl)C0-C4alkyl, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R23 can be optionally substituted;
R24 and R25 are taken together with the nitrogen to which they are attached to form a 4- to 7-membered monocyclic heterocycloalkyl group, or a 6- to 10-membered bicyclic heterocyclic group having fused, spiro, or bridged rings, and each R24 and R25 can be optionally substituted;
L is

R17 is hydrogen;
R18 and R18? are independently chosen from hydrogen, halogen, hydroxymethyl, and methyl;
m is 0, 1, 2, or 3;
B is a monocyclic or bicyclic carbocyclic; a monocyclic or bicyclic carbocyclic-oxy group;
a monocyclic, bicyclic, or tricyclic heterocyclic group having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and from 4 to 7 ring atoms per ring; C2-C6alkenyl, C2-C6alkynyl; -(C0-C4alkyl)(aryl); -(C0-C4alkyl)(heteroaryl); or -(C0-C4alkyl)(biphenyl) each of which B is unsubstituted or substituted with one or more substituents independently chosen from R33 and R34, and 0 or 1 substituents chosen from R35 and R36;
R33 is independently chosen from halogen, hydroxyl, —COOH, cyano, C1-C6alkyl, C2-C6alkanoyl, C1-C6alkoxy, —C0-C4alkylNR9—SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy;
R34 is independently chosen from nitro, C2-C6alkenyl, C2-C6alkynyl, C1-C6thioalkyl, —C3-C7cycloalkyl, —B(OH)2, -JC(O)NR9R23, -JOSO2OR21, —C(O)(CH2)1-4S(O)R21, —O(CH2)1-4S(O)NR21R22, -JOP(O)(OR21)(OR22), -JP(O)(OR21)(OR22), -JOP(O)(OR21)R22, -JP(O)(OR21)R22, -JOP(O)R21R22, -JP(O)R21R22, -JSP(O)(OR21)(OR22), SP(O)(OR21)(R22), -JSP(O)(R21)(R22), -JNR9P(O)(NHR21)(NHR22), -JNR9P(O)(OR21)(NHR22), -JNR9P(O)(OR21)(OR22), -JC(S)R21, -JNR21SO2R22, -JNR9S(O)NR10R22, -JNR9SO2NR10R22, -JSO2NR9COR22, JSO2NR9CONR21R22, -JNR21SO2R22, -JC(O)NR21SO2R22, -JC(NH2)NR22, -JC(NH2)NR9S(O)2R22, -JOC(O)NR21R22, -JNR21C(O)OR22, -JNR21OC(O)R22, —(CH2)1-4C(O)NR21R22, -JC(O)R24R25, -JNR9C(O)R21, -JC(O)R21, -JNR9C(O)NR10R22, —CCR21, —(CH2)1-4OC(O)R21, and -JC(O)OR23; each of which R34 may be unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, amino, oxo, —B(OH)2, —Si(CH3)3, —COOH, —CONH2, —P(O)(OH)2, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C1-C6alkoxy, —C0-C2alkyl(mono- and di-C1-C4alkylamino), C1-C6alkylester, C1-C4alkylamino, C1-C4hydroxylalkyl, C1-C2haloalkyl, and C1-C2haloalkoxy;
R35 is independently chosen from naphthyl, naphthyloxy, indanyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl containing 1 or 2 heteroatoms chosen from N, O, and S, and bicyclic heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and containing 4- to 7-ring atoms in each ring, each of which R35 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy; and
R36 is independently chosen from tetrazolyl, (phenyl)C0-C2alkyl, (phenyl)C1-C2alkoxy, phenoxy, and 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently chosen from N, O, B, and S, each of which R36 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, —OSi(CH3)2C(CH3)3, —Si(CH3)2C(CH3)3, C1-C2haloalkyl, and C1-C2haloalkoxy; and
J is independently selected at each occurrence from a covalent bond, C1-C4alkylene, —OC1-C4alkylene, C2-C4alkenylene, and C2-C4alkynylene.

US Pat. No. 10,189,867

ORGANOSILICON MODIFIED PHOTOINITIATOR AND A PHOTO-CURABLE ADHESIVE COMPOSITION COMPRISING THE SAME

1. An organosilicon modified photoinitiator represented by the general formula (I):wherein,R1 and R2 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl;
one of R3, R4, R5, R6, and R7 is SIL1-X, and the others are each independently selected from the group consisting of hydrogen, C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl, and halogen;
X is a direct bond or C1-C12 alkylene; and
SIL1 and SIL2 are each independently represented by the formula —SiR8R9R10 or (R?SiO3/2)a(R?2SiO2/2)b(R??3SiO1/2)c, wherein
R8, R9 and R10 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl, and aryl C1-C3 alkyl,
R?, R? and R?? each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, and phenyl C1-C3 alkyl, and
a, b, and c are numbers that satisfy a?0, b?0, c>0, the ratio of a to c is from 0 to 100, and the ratio of b to c is from 0 to 10.

US Pat. No. 10,189,864

METAL COMPLEXES BASED ON A BIS(2-PYRIDYLMETHYL)AMINE-BASED SCAFFOLD AND METHODS OF MAKING THE SAME

Lawrence Livermore Nation...

1. A catalyst, comprising:a ligand comprising a bis(2-pyridylmethyl)amine group, wherein the ligand comprises at least three sp2 nitrogen atoms and at least one sp3 nitrogen atom, and wherein the ligand has a structure selected from the group consisting of:

wherein each R is independently selected from the group consisting of: hydrogen, an ester, an alcohol, and polyethylene glycol (PEG); and
at least one metal cation complexed to the nitrogen atoms of the ligand, wherein the at least one metal cation includes one or more of: Zn2+, and Co2+.

US Pat. No. 10,189,861

PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS

DANA-FARBER CANCER INSTIT...

1. A compound having the formula:
or a pharmaceutically acceptable salt thereof,
wherein,
R? is H or methyl;
L is absent, SO2, or CO;
X is H, methyl, fluoro, chloro, phenyl, pyridinyl, thiophenyl, —NH—CO—CH?CH—CH2—N(CH3)2, —S(O)2—N(CH3)2, or

Z is NH or N—C1-C3 alkyl;
R2 is hydrogen or methyl;
R6 is hydrogen; and
R1 is H, C?O(CH3),

US Pat. No. 10,189,860

HYDRATES OF DOLUTEGRAVIR SODIUM

1. A crystalline form of dolutegravir sodium of formula (I)characterized by a powder X-ray diffractogram comprising peaks at 2-Theta angles of 7.9±0.2°, 9.4±0.2°, 12.5±0.2°, 15.9±0.2° and 20.8±0.2°, when measured with Cu-Katz radiation having a wavelength of 0.15419 nm at room temperature wherein the crystalline form comprises 0.2 to 0.7 mol of water per mol dolutegravir sodium of formula (I) when measured at a relative humidity from 30 to 70% and a temperature of 25±0.1° C.

US Pat. No. 10,189,858

DEUTERIUM-ENRICHED ISOINDOLINONYL-PIPERIDINONYL CONJUGATES AND OXOQUINAZOLIN-3(4H)-YL-PIPERIDINONYL CONJUGATES AND METHODS OF TREATING MEDICAL DISORDERS USING SAME

DeuteRx, LLC, Andover, M...

1. A deuterium-enriched compound, wherein the compound is selected from the group consisting of:(i) a compound of Formula II represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%,
(ii) a compound of Formula III represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%,
(iii) a compound of Formula IV represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%, and
(iv) a compound of Formula IV represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%.

US Pat. No. 10,189,857

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Vanderbilt University, N...

1. A compound of formula (I),
or a pharmaceutically acceptable salt thereof, wherein:
W is selected from CR1 and N;
X is selected from CR1 and N;
Y is selected from CR1 and N;
each R1 is independently selected from hydrogen and C1-C6 alkyl;
R2 is hydrogen or C1-C6 alkyl;
R3a and R3b are each independently selected from hydrogen and C1-C6 alkyl, or R3a and R3b are taken together with the nitrogen atom to which they are attached to form an optionally substituted ring;
R4a is hydrogen and R4b is selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heteroalkyl, heterocyclyl, and —(CRaRb)n—Z, any of which may be optionally substituted; or R4a and R4b, together with the nitrogen atom to which they are attached, are taken together to form an optionally substituted heterocyclic ring;
Ra is hydrogen;
Rb is hydrogen;
Z is selected from halo, —OR, —SR, —C(O)R, —C(O)OR, —S(O)R, —SO2R, —NR2, —C(O)NR2, —S(O)2NR2, aryl, heteroaryl, cycloalkyl, and heterocyclyl, any of which may be optionally substituted;
n is 1, 2, 3, 4, 5, 6, 7, or 8; and
each R is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, heteroaryl, heteroarylalkyl, and heteroalkyl, any of which may be optionally substituted.

US Pat. No. 10,189,856

USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSC)

1. A method for reducing collagen production in dermal fibroblasts, reducing myofibroblast differentiation and/or for triggering redifferentiation of myofibroblast in a patient suffering from a fibrotic disease selected from the group consisting of systemic sclerosis (SSc), diffuse systemic sclerosis (dSSc), limited systemic sclerosis (lSSc), overlap type of systemic sclerosis, undifferentiated type of systemic sclerosis, systemic sclerosis sine scleroderma, skin fibrosis, nephrogenic fibrosing dermopathy (NFD), nephrogenic systemic fibrosis (NSF), systemic sclerosis (SSc) concomitant fibrosis of internal organs, and keloid formation, comprising administering an effective amount of a compound according to one of formulae (3), (6) or (27)to the patient in need thereof; wherein reduction of collagen production in dermal fibroblasts, reduction of myofibroblast differentiation and/or triggering redifferentiation of myofibroblast occurs without vasodilation.

US Pat. No. 10,189,851

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A compound of the structure:

US Pat. No. 10,189,849

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A compound of the structure:

US Pat. No. 10,189,848

ETHYNYL DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula IwhereinR1 is lower alkyl;
R2 is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be in different positions;
n is 0, 1 or 2;
V/U are independently from each other O or CH2, wherein V and U cannot be simultaneously O;
L is a five or six membered heteroaryl group, selected from
or a pharmaceutically acceptable salt or acid addition salt, a racemic mixture, or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.

US Pat. No. 10,189,847

OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING SAID COMPOUND

ADEKA CORPORATION, Tokyo...

1. An oxime ester compound represented by general formula (I):wherein R1 and R2 each independently represent R11, OR11, COR11, SR11, CONR12R13, or CN;R11, R12, and R13 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, and R13 being optionally further substituted by R21, OR21 COR21, SR21, NR22R23, CONR22R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
R21, R22, and R23 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R21, R22, and R23 being optionally further substituted by a hydroxyl group, a nitro group, CN, a halogen atom, a hydroxyl group, or a carboxyl group,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, R13, R21, R22and R23 having an alkylene moiety optionally interrupted by —O—, —S—, —COO—, —OCO—, —NR24—, —NR24CO—, —NR24COO—, —OCONR24—, —SCO—, —COS—, —OCS—, or —CSO— at 1 to 5 sites provided that no two oxygen atoms are directly bonded to each other;
R24 represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, R13, R21, R22, R23, and R24 having an alkyl moiety that is optionally branched or cyclic;
R3 represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R3 having an alkyl moiety that is optionally branched or cyclic,
R3 and R7, R3 and R8, R4 and R5, R5 and R6, and R6 and R7 being optionally taken together to form a ring,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R3 being optionally further substituted by R21, OR21, COR21, SR21, NR22R23, CONR23R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
R4, R5, R6, and R7 each independently represent R11, OR11, SR11, COR14, CONR15R16, NR12COR11, OCOR11, COOR14, SCOR11, OCSR11, COSR14, CSOR11, a hydroxyl group, CN, or a halogen atom,
R4 and R5, R5 and R6, and R6 and R7 being optionally taken together to form a ring;
R14, R15, and R16 each represent a hydrogen atom or an alkyl group having 1 to 20 carbon atoms,
the alkyl group represented by R14, R15, and R16 being optionally branched or cyclic;
R8 represents R11, OR11, SR11, COR11, CONR12R13, NR 12COR11, OCOR11, COOR11, SCOR11, OCSR11, COSR11, CSOR11, a hydroxyl group, CN, or a halogen atom; and
n represents 0 or 1, and
the oxime ester compound represented by general formula (I) satisfies any of following (1) to (4):
(1) n is 1,
(2) at least one of R4, R5, R6, and R7 is R11, OR11, SR11, COR14, CONR15R16, NR12COR11, OCOR11, SCOR11, OCSR11, COSR14, CSOR11, a hydroxyl group, CN, or a halogen atom; and satisfies the following conditions (2-1) and (2-2);
(2-1) when any of R4, R5, R6, and R7 is R11, R11 represents an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms, and the hydrogen atom of the group represented by R11 is further substituted by OR21, COR21, SR21, NR22R23, CONR22R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
(2-2) when any of R4, R5, R6, and R7 is OR11, OR11, OR11represents an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms, and the hydrogen atom of the group represented by R11 is further substituted by OR21, COR21, SR21, NR22R23, CONR22R23, —NR22 —OR23, —NCOR22 —OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
(3) R3 is an arylalkyl group having 7 to 30 carbon atoms or a heterocyclic group having 2 to 20 carbon atoms,
(4) R3 and R7, R3 and R8, R4 and R5, R5 and R6, or R6 and R7 are taken together to form a ring.

US Pat. No. 10,189,846

HEPATITIS B ANTIVIRAL AGENTS

ENANTA PHARMACEUTICALS, I...

1. A compound represented by Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
A is optionally substituted monocyclic heteroaryl;
B is hydrogen or methyl;
X is optionally substituted phenyl;
Y is optionally substituted phenyl or optionally substituted monocyclic heteroaryl; and
R and Z are taken together with the atoms to which they are attached to form an optionally substituted 4- to 12-membered heterocyclic.

US Pat. No. 10,189,842

WNT PATHWAY MODULATORS

Agency for Science, Techn...

10. A pharmaceutical composition comprising a compound according to claim 1 in combination with one or more therapeutically acceptable adjuvents, diluents or carriers.

US Pat. No. 10,189,839

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

ACTELION PHARMACEUTICALS ...

1. A compound of Formula (I)
wherein
X represents —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, —S—, *—CH2—O—, or *—CH2—NRx— wherein Rx represents hydrogen, —CO—(C1-4)alkyl, —(C1-3)alkyl-(C3-6)cycloalkyl, (C3-6)cycloalkyl, or —CO—(C1-4)alkoxy; wherein the asterisks indicate the bond attached to the imidazole ring;
R1a and R1b independently represent hydrogen, methyl, ethyl; or R1a and R1b together with the carbon atom to which they are attached to form a cyclopropyl ring;
R2 represents aryl, or heteroaryl, wherein said aryl or heteroaryl independently is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from:
(C1-4)alkyl;
(C1-4)alkoxy;
(C3-6)cycloalkyl;
(C1-3)fluoroalkyl;
(C1-3)fluoroalkoxy;
halogen;
cyano;
—(CH2)n—NR21R22; wherein n represents the integer 0 or 1; and
R21 and R22 independently represent hydrogen or (C1-4)alkyl; or
R21 and R22 together with the nitrogen atom to which they are attached to form a 4- to 7-membered saturated ring, wherein said ring optionally includes one ring oxygen atom;
—CO—NR23R24, wherein R 23 and R24 independently represent hydrogen or (C1-4)alkyl;
—CO—NH—CN;
—NR25—CO—NR26R27, wherein R25, R26 and R27 independently represent hydrogen or (C1-4)alkyl;
—CO—(C1-4)alkoxy;
phenyl;
hydroxy-(C1-4 )alkyl;
(C1-3)alkoxy-(C1-4)alkyl;
hydroxy-(C2-4)alkoxy; or
(C1-3)alkoxy-(C2-4)alkoxy;
R3 represents aryl, or heteroaryl, wherein said aryl or heteroaryl independently is unsubstituted, or mono-, di-, or tri-substituted, wherein the substituents are independently selected from:
—NR4—Y—R5, wherein
R4 represents hydrogen or (C1-3)alkyl; Y represents a direct bond; and R5 represents (C1-4)alkyl, or (C3-6)cycloalky; or
R4 represents hydrogen or (C1-3)alkyl; Y represents —NRY— wherein RY represents (C1-3)alkyl; and R5 represents (C1-4)alkyl; or
R4 and R5 together with the nitrogen and the —SO2—Y-group to which they are attached to form a 5-, 6-, or 7-membered ring, wherein Y represents a direct bond or —NRY— wherein RY represents (C1-3)alkyl;
—CO—NR6R7, wherein R6 and R7 independently represent hydrogen, (C1-4)alkyl, or (C3-6)cycloalkyl;
—SO2—R8 wherein R8 represents (C1-5)alkyl, or —NR81R82, wherein R81 and R82 independently represent hydrogen or (C1-4)alkyl;
—(CH2)m—NR9R10; wherein m represents the integer 0 or 1; and
R9 and R10 independently represent hydrogen, (C1-4)alkyl, (C2-3)fluoroalkyl, hydroxy-(C2-4)alkyl, (C1-4)alkoxy-(C2-4)alkyl; or
R9 and R10 together with the nitrogen to which they are attached to form a 4-to 7-membered ring optionally including an oxygen ring atom or a group —NR11— wherein
R11 represents (C1-4)alkyl, and wherein said ring is optionally substituted with one or two fluorine substituents;
(C1-4)alkyl;
(C3-6)cycloalkyl;
(C1-4)alkoxy;
(C1-3)fluoroalkyl;
(C1-3)fluoroalkoxy;
halogen;
cyano; or
5-membered heteroaryl;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,835

DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

NOVIRA THERAPEUTICS, INC....

1. A compound of Formula IV:
or a pharmaceutically acceptable salt thereofwhereinY is selected from a bond, —C(O)—, and —SO2—;
R1 is selected from C(O)ORc, C(O)Rc, C(O)NRdRe, and —C(O)NRdN(Rd)2;
R2 is, at each occurrence, independently selected from H, —OH, halo, and C1-C6-alkyl;
R3 is, at each occurrence, independently selected from H, —OH, halo, and C1-C6-alkyl;
R4 is selected from (CR8R9)p—C6-C12-aryl and (CR8R9)p—C1-C9-heteroaryl, wherein aryl and heteroaryl are optionally substituted with 1, 2,or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R5 is, at each occurrence, independently selected from H, —OH, and halo;
R6 is, at each occurrence, independently selected from H, —OH, and halo;
alternatively,

R8 is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R9 is, at each occurrence, independently selected from H and C1C6-alkyl;
Rc is selected from H, C1-C6-alkyl,C1-C6-alkyl-OH, C0-C6-alkyl-C3-C8-cycloalkyl, C2-C8-heterocyclyl, C6-C12-aryl, and C1-C9-heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, and —O—C1-C6-alkyl;
Rd is selected from H, C1-C6-alkyl, and C1-C6-alkyl-OH;
Re is selected from H, C1-C6-alkyl, C1-C6-alkyl-OH, C1-C6-alkyl-OC1-C6-alkyl, C0-C6-alkyl-C3-C8-cycloalkyl, C2-C8-heterocyclyl, C6-C12-aryl, and C1-C9-heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, and —O—C1-C6-alkyl;
m is 0, 1, or 2; and
p is 0, 1, 2, 3, or 4.

US Pat. No. 10,189,833

SOLID FORMS OF A COMPOUND MODULATING KINASES

Plexxikon Inc., Berkeley...

1. A method for treating a subject suffering from a disease or condition mediated by a protein kinase selected from c-fms, c-kit, Flt3 or a combination thereof, or mediated by macrophages or microglia, comprising administering to the subject a therapeutically effective amount of a crystalline form of Compound I:characterized by an X-ray powder diffractogram comprising peaks (±0.2°) at 7.3, 23.3 and 28.2° 2? as determined on a diffractometer using Cu—K? radiation.

US Pat. No. 10,189,832

CRYSTALLINE SOLID FORMS OF A BET INHIBITOR

Incyte Corporation, Wilm...

1. A solid form of a compound having the formula:
wherein the solid form is crystalline;
and wherein the solid form has Form I and has a characteristic XRPD peak, in terms of 2-theta, at about 12.7 degrees.

US Pat. No. 10,189,830

ALKYL-HETEROARYL SUBSTITUTED QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS

BIOELECTRON TECHNOLOGY CO...

1. A compound of Formula I or Formula II:
wherein:
R1, R3 and R4 are independently C1-C6 alkyl or O—C1-C6 alkyl;
R2 is heteroaryl selected from the group consisting of benzoimidazole, benzothiazole, and benzoxazole, optionally substituted with one or two substituents independently selected from the group consisting of halo, —CH3, —CF3, —OCH3, and —C(O)—N(R5)(R6), wherein the substituents are independently linked to the heteroaryl by either a —C— or —N—within the heteroaryl; where the attachment point of the heteroaryl group to the rest of the molecule is either through a C or N in the rings;
R5 and R6 are independently selected from the group consisting of —H, —C1-C6 alkyl, and —C1-C6 alkyl-hydroxy, or wherein R5 and R6 together with the N to which they are attached form a saturated or unsaturated 3-8 membered ring, optionally incorporating one, two, or three additional heteroatoms each independently selected from the group consisting of N, O, and S, and wherein the ring is optionally substituted with —C1-C6 alkyl; and
z is 3;
or a stereoisomer, mixture of stereoisomers, solvate, hydrate, pharmaceutically acceptable salt or prodrug ester thereof.

US Pat. No. 10,189,826

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Medivation Technologies L...

1. A compound of Formula (IIa):
or a pharmaceutically acceptable salt thereof, wherein:
RC5 is halogen;
each RC7 and RC8 is independently hydrogen, R1, or —SO2RC12; or RC7 and RC8 are taken together with the N to which they are attached to form a C3-C8 heterocycle optionally substituted with one or more R1 or R3;
R1 is C1-C6 linear or branched alkyl, C2-C6 linear or branched alkenyl, C2-C6 linear or branched alkynyl, C3-C6 cycloalkyl, C3-C6 cycloalkylmethyl, C3-C6 cycloalkenyl, aryl, or heteroaryl; each optionally substituted with one or more R3;
R3 is halogen, —CN, —OH, —O(Alkyl), ?O, —NO2, —SH, —S(Alkyl), —S(O)(Alkyl), —S(O)2(Alkyl), —CH2OCH3, —OBn, —CO2H, —CO2(Alkyl), —NR10R11, —CONR10R11, or —S(O)2NR10R11;
R10 and R11 are independently hydrogen, C1-C6 linear or branched alkyl, —C(O)RC12, —C(O)2RC12, —C(O)N(RC12)2, —SO2RC12, or are taken together with the N to which they are attached to form a C3-C8 heterocyclyl; and
RC12 is hydrogen, a linear or branched C1-C6 alkyl, a linear or branched C2-C6 alkenyl, a linear or branched C2-C6 alkynyl, or aryl; wherein each alkyl, alkenyl, alkynyl, or aryl group is optionally substituted with one or more halogen atoms, one or more —NH2 groups, or one or more —OH groups.

US Pat. No. 10,189,824

PYRIMIDINE-DIAMINE DUAL HSP90/TRAP1 INHIBITORS

Calasia Pharmaceuticals, ...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R1 is hydrogen, halo, (C1-C3)alkyl, halo(C1-C3)alkyl, (C1-C3)alkoxy, or halo(C1-C3)alkoxy;
R3, R4, and R5 are independently hydrogen, halo, (C1-C3)alkyl, halo (C1-C3)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, cyano,
R2 is heteroaryl or heterocycyl, each of which are optionally substituted with 1 to 2 groups independently selected from R6, but not 4-morpholinyl or benzo[d][1,3]dioxol-5-yl;p is 0, 1, or 2;
R6 is selected from halo, cyano, nitro, amino, hydroxy, carboxy, (C1-C6)alkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroalkyl, heterocyclylalkyl, hydroxy(C1-C6)alkyl, CO2H, (CH2)1-3COOH, (C1-C3)alkylcarbonyloxy, (C3-C6)cycloalkyl, hydroxy(C3-C6)cycloalkyl, (C4-C7)cycloalkylalkyl, (C2-C6)alkenyl, halo(C2-C6)alkenyl, hydroxy(C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl(C2-C4)alkynyl, halo(C1-C6)alkyl, halo(C3-C6)cycloalkyl, halo(C4-C7)cycloalkylalkyl, (C1-C6)alkoxy, (C3-C6)cycloalkoxy, (C4-C7)cycloalkylalkoxy, halo(C1-C6)alkoxy, halo(C3-C6)cycloalkoxy, halo(C4-C7)cycloalkylalkoxy, (C1-C6)alkylthio, (C3-C6)cycloalkythio, (C4-C7)cycloalkylalkylthio, halo(C1-C6)alkylthio, halo(C3-C6)cycloalkythio, halo(C4-C7)cycloalkylalkylthio, (C1-C6)alkylsulfinyl, (C3-C6)cycloalkylsulfinyl, (C4-C7)cycloalkylalkylsulfinyl, halo(C1-C6)alkylsulfonyl, halo(C3-C6)cycloalkylsulfinyl, halo(C4-C7)cycloalkylalkylsulfinyl, (C1-C6)alkylsulfonyl, (C3-C6)cycloalkylsulfonyl, (C4-C7)cycloalkylalkylsulfonyl, halo(C3-C6)cycloalkylsulfonyl, halo(C4-C7)cycloalkylalkylsulfonyl, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkoxy(C1-C6)alkoxy, halo(C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, H2NCO, H2NSO2, (C1-C6)alkylaminocarbonyl, di(C1-C6)alkylaminocarbonyl, (C1-C3)alkoxy(C1-C3)alkylaminocarbonyl, heterocyclylcarbonyl, (C1-C6)alkylaminosulfonyl, di(C1-C6)alkylaminosulfonyl, heterocyclylsulfonyl, (C1-C6)alkylcarbonylamino, (C1-C6)alkyl-carbonylamino(C1-C6)alkyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkoxy(C1-C6)alkyl, hydroxy(C1-C6)alkoxy, oxo, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl amino(C2-C6)alkoxy, (C1-C6)alkylamino(C2-C6)alkoxy, di(C1-C6)alkylamino(C2-C6)alkoxy, (C1-C6)alkylcarbonyl, hydroxy(C1-C6)alkylcarbonyl, (C1-C6)alkylhydroxycarbonyl, (C1-C6)alkylhydroxy(C1-C6)alkyl, (C3-C6)cycloalkylcarbonyl, (C3-C6)cycloalkylaminocarbonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl, di(C3-C6)cycloalkylaminocarbonyl, (C3-C6)cycloalkylaminosulfonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminosulfonyl, di(C3-C6)cycloalkylaminosulfonyl, cyano(C1-C6)alkyl, aminocarbonyl(C1-C6)alkyl, (C1-C6)alkylaminocarbonyl(C1-C6)alkyl, di(C1-C6)alkylaminocarbonyl(C1-C6)alkyl, (C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl(C1-C6)alkyl, [(C1-C6)alkyl(C4-C6)heterocyclyl](C1-C6)alkyl, and di(C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl;
R7 and R8 are independently hydrogen or alkyl; and
R9 is H or alkyl.

US Pat. No. 10,189,823

NEPRILYSIN INHIBITORS

1. A method for treating hypertension, the method comprising administering to patient a therapeutically effective amount of a compound of the following structure:or a pharmaceutically acceptable salt thereof;wherein the hypertension is selected from the group consisting of primary hypertension, secondary hypertension, hypertension with accompanying renal disease, severe hypertension with or without accompanying renal disease, pulmonary hypertension, and resistant hypertension.

US Pat. No. 10,189,822

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

3-V Biosciences, Inc., M...

1. A method of treating a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
wherein the cancer is selected from mantle cell lymphoma; chronic myelogenous leukemia; sarcoma; endometrial tumors; non-small cell lung carcinoma; gastric carcinomas; hepatocellular tumors; and head and neck cancer.

US Pat. No. 10,189,821

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR I

Cancer Research Technolog...

1. A compound of formula I shown below:
wherein:
A1 is selected from N or CR1, A2 is selected from N or CR2, with the proviso that only one of A1 or A2 can be N;
R1 and R2 are each independently selected from hydrogen, fluoro, chloro, cyano, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy;
R4 is selected from fluoro, chloro, bromo, iodo, CF3, OCF3, cyano, NO2, (1-4C)alkyl, (1-4C)alkoxy, or a group of the formula:
W—X-Y—Z
wherein
W is absent or (1-3C)alkylene;
X is —O— or —N(Ra)—, wherein Ra is selected from hydrogen or (1-2C)alkyl;
Y is absent or a (1-3C)alkylene;
Z is hydrogen, (1-6C)alkyl or (3-6C)cycloalkyl;
and wherein any alkylene, alkyl or cycloalkyl group present in a R4 substituent group is optionally further substituted by one or more substituent groups independently selected from halo, hydroxy, NRbRc, (1-2C)alkoxy, (1-2C)haloalkyl or (1-2C)haloalkoxy, and wherein Rb and Rc are each independently selected from hydrogen or (1-3C)alkyl;
Q is a group of formula III:

wherein
A5 is selected from N or CR5, where R5 is selected from hydrogen, halo, cyano, nitro, hydroxy, NRqRu, (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteroaryl, or 5 or 6 membered heterocyclyl; wherein Rq and Ru are each independently selected from hydrogen or (1-3C)alkyl, and wherein any (1-3C)alkyl, (1-3C)alkoxy, 5 or 6-membered heteraryl, or 5 or 6 membered heterocyclyl group present in a R5 substituent group is optionally substituted by one or more substituents selected from halo, cyano, nitro, hydroxy, NRvRw, or (1-3C)alkoxy, wherein Rv and Rw are each independently selected from hydrogen or (1-3C)alkyl;
Ring A is:
a fused phenyl ring;
a fused 5 or 6 membered carbocyclic ring;
a fused 5 or 6 membered heteroaryl ring comprising one or two heteroatoms independently from N, S or O; or
a fused 5, 6 or 7-membered heterocyclic ring comprising one or two heteroatoms independently from N, S or O;
A6 is selected from N, O, S, S(O), S(O)2, CR6, C(R6)2, NR60, where R6 is selected from hydrogen, oxo, fluoro, chloro, (1-2C)alkyl, (1-2C)alkoxy, (1-2C)haloalkoxy or (1-2C)haloalkyl and R60 is hydrogen, ?O, (1-6C)alkyl, —C(O)—R61, —C(O)O—R61, or
—C(O)N(R62)R61, wherein R61 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R62 is selected from hydrogen or (1-3C)alkyl;
A7 is selected from N, O, CR7, S, S(O), S(O)2, C(R7)2, NR70, where R70 is hydrogen, ?O, (1-6C)alkyl, —C(O)—R71, —C(O)O—R71, or —C(O)N(R72)R71, wherein R71 is selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, aryl, heteroaryl or heterocyclyl and R72 is selected from hydrogen or (1-3C)alkyl;
m is 0, 1 or 2;
R7 and R11 are each independently halo, cyano, oxo, or a group
W2—X2—Y2—X3—Z2
wherein
W2 is absent or a linker group of the formula —[CRxRy]r— in which r is an integer selected from 1, 2, 3 or 4, and Rx and Ry are each independently selected from hydrogen or (1-2C)alkyl;
X2 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(ORz)—, —N(Rz)—, —N(Rz)—C(O)—, —N(Rz)—C(O)O—, —C(O)—N(Rz)—, —N(Rz)C(O)N(Rz)—, —S—, —SO—, —SO2—, —S(O)2N(Rz)—, or
—N(Rz)SO2, wherein
Rz is selected from hydrogen or methyl;
Y2 is absent or a linker group of the formula —[CRaaRbb]s— in which s is an integer selected from 1, 2, 3 or 4, and Raa and Rbb are each independently selected from hydrogen or (1-2C)alkyl;
X3 is absent, —O—, —C(O)—, —C(O)O—, —OC(O)—, —CH(ORcc)—, —N(Rcc)—, —N(Rcc)—C(O)—, —N(Rcc)—C(O)O—, —C(O)—N(Rcc)—, —N(Rcc)C(O)N(Rcc)—, —S—, —SO—, —SO2—, —S(O)2N(Rcc)—, or —N(Rcc)SO2, wherein Rcc is selected from hydrogen or methyl; and
Z2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, aryl, (3-6C)cycloalkyl, (3-6C)cycloalkenyl, heteroaryl, or heterocyclyl,
and wherein Z2 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, carboxy, NRddRee, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-4C)alkanoyl, (1-4C)alkylsulphonyl, aryl, aryloxy, heterocyclyl, heterocyclyloxy, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryloxy, heteroaryl-(1-2C)alkyl, C(O)NRddRee, NRddC(O)Ree, NRddSO2Ree and SO2NRddRee; wherein Rdd and Ree are each independently selected from hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or Rdd and Ree can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring; and
wherein any alkyl, aryl, heterocyclyl or heteroaryl group present in a substituent group on Z2 is optionally further substituted by halo, cyano, nitro, hydroxy, carboxy, NRffRgg, (1-2C)alkoxy, or (1-2C)alkyl; wherein Rff and Rgg are selected from hydrogen or (1-2C)alkyl;
with the proviso that when R7 is hydrogen (i.e. when W2, X2, Y2, and X3 are absent and Z2 is hydrogen) then ring A is not a fused dioxane ring;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,189,820

HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS

GlaxoSmithKline Intellect...

1. A compound which is (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide having the structure ofor a tautomer thereof,or a pharmaceutically acceptable salt thereof,or a hydrate thereof.

US Pat. No. 10,189,819

FACTOR IXA INHIBITORS

Mochida Paraceuticals Co....

1. A compound of Formula I:
wherein A is selected from:

R1 is phenyl, which is optionally substituted with halo, R5, (C?O)OR5, (C?O)NR5R6 or C1-3 alkyl(C?O)OR5; or heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, R5, OR5, NR5R6 and C1-3 alkyl-NR5R6;
R2 is hydrogen or C1-6 alkyl;
R3 is heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, cyclopropyl, R5, OR5, (C?O)OR5 and CH2SO2CH3;
each R4 is independently selected from halo, R5 or OR5,
each R5 is hydrogen or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
R6 is hydrogen, cyclopropyl or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
Ra is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rb is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rc is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rd is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Re is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rf is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rg is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rh is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
n is an integer between zero and two;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,817

INHIBITORS OF BRUTON'S TYROSINE KINASE

BIOGEN MA INC., Cambridg...

1. A compound of formula A:wherein —ORLG is a suitable leaving group.

US Pat. No. 10,189,812

BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION

THE KEY LABORATORY OF CHE...

1. A compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and pharmaceutically acceptable salt thereof,
wherein,
X1 is selected from hydrogen, halogen, nitro, nitroso, —SO3H or optionally substituted sulfonyl;
X2 is independently selected from hydrogen, halogen, nitro, nitroso, —SO3H, optionally substituted amino or optionally substituted sulfonyl;
X3 and X4 are hydrogen;
said optionally substituted sulfonyl is selected from —SO3H, sulfonyl substituted with arylamino, sulfonyl substituted with alkyl sulfonyl substituted with alkyl substituted with alkoxy or sulfonyl substituted with halogen;
said optionally substituted amino is selected from amino substituted with alkylcarbonyl, amino substituted with hydroxy substituted alkylcarbonyl, amino substituted with alkylcarbonyl, amino substituted with alkenylcarbonyl, amino substituted with alkynylcarbonyl, amino substituted with alkoxycarbonyl, amino substituted with aryl substituted alkoxycarbonyl, amino substituted with cycloalkylcarbonyl, amino substituted with arylcarbonyl, amino substituted with halogen substituted arylcarbonyl, amino substituted with alkoxy substituted arylcarbonyl, amino substituted with haloalkyl substituted arylcarbonyl, amino substituted with furylcarbonyl, amino substituted with thienylcarbonyl, amino substituted with morpholinylcarbonyl, amino substituted with aminocarbonyl, amino substituted with alkoxycarbonylcarbonyl, amino substituted with alkylsulfonyl, amino substituted with alkenylsulfonyl, amino substituted with alkynylsulfonyl, amino substituted with alkoxysulfonyl, amino substituted with arylsulfonyl, amino substituted with nitro substituted arylsulfonyl, amino substituted with alkyl substituted arylsulfonyl, amino substituted with halogen substituted arylsulfonyl, amino substituted with aminosulfonyl or arylalkylsulfonyl substituted amino;
R1 is independently selected from hydrogen, nitroso, alkyl, alkyl substituted with aryl, alkenyl, alkynyl, aryl, arylcarbonyl, alkylcarbonyl, alkenylcarbonyl or alkynylcarbonyl;
R2 is hydrogen;
x is 1, 2 or 3;
y is 1, 2, 3 or 4; and
z is 1 or 2;
provided that:
X1, X2, X3 and X4 are not hydrogen simultaneously; and
when one of X1 and X2 is halogen, the rest of X1 and X2 are independently selected from hydrogen, nitro, nitroso, —SO3H, optionally substituted amino or optionally substituted sulfonyl, but they are not hydrogen simultaneously and X1 is not optionally substituted amino.