US Pat. No. 10,189,277

DEVICE AND METHOD FOR PRETREATING AND PRINTING TEXTILE SURFACES

Aeoon Technologies GmbH, ...

1. Device for pretreating and printing textile surfaces havingat least one pallet for accommodating and holding a textile to be printed, wherein, for the purpose of printing, the textile is provided on a printing face,
a pretreatment means, by means of which the textile can be pretreated prior to printing, wherein on the textile a pretreatment fluid is applied in a pretreatment area,
a printing means having at least one print head, by means of which the textile can be printed with a printed image in the pretreatment area,
a movement means, by means of which the at least one pallet can be moved relative to the pretreatment means and the printing means, and
a programmable control means, by means of which the printing means, the pretreatment means and/or the movement means can be controlled,whereina detection means is provided, by means of which the textile can be detected, and
the detection means is connected to the programmable control means, wherein, depending on the detected textile, the pretreatment area can be applied individually onto a partial area of the printing face of the textile.

US Pat. No. 10,189,244

METHOD FOR SELECTING A FORMAT FOR A SECTION TO BE PRINTED

Hewlett-Packard Gesellsch...

1. A method for producing a print product including selecting a print section format for a section to be printed having at least one signature, the steps comprising:selecting, by a processor, a print section layout that divides the section to be printed in a running direction and in a transversal direction into adjacent units;
assigning the at least one signature which includes pages in a page format of the print product to a unit of the adjacent units;
determining border regions outside of the at least one signature, longitudinal dimensions in a running direction of the at least one signature, and transversal dimensions in a transversal direction of the at least one signature, wherein at least one of the border regions adjoins an adjacent border region for an adjacent page;
implementing a fold-over outside of at least one of the border regions;
calculating an optimal longitudinal dimension from the sums of the longitudinal dimensions and the border regions adjoining in the running direction, the fold-over outside of at least one of the border regions in the running direction, and a percentage of a difference between a longitudinal dimension and a minimum longitudinal dimension;
calculating an optimal transversal dimension from the sums of the transversal dimensions and the border regions adjoining in the transversal direction, and a percentage of a difference between a transversal dimension and a minimum transversal dimension; and
selecting the print section format so that the longitudinal dimension of the print section format is at least equal to the optimal longitudinal dimension and the transversal dimension of the print section format is at least equal to the optimal transversal dimension;
imprinting the section to be printed;
collating the at least one signature for the imprinted section; and
cutting the imprinted and collated section into page format to form the print product.

US Pat. No. 10,189,236

SYSTEM, METHOD, AND APPARATUS FOR MAGNETIC SURFACE COVERINGS

Golconda Holdings, LLC, ...

1. A system for finishing a wall comprising:a set of modular wall covering units comprising an inner attractant layer and a decorative outer layer;
a magnetic underlayment comprising an isotropic magnetic sheeting, the magnetic underlayment having been heat treated, wherein the heat treatment of the magnetic underlayment is at 158 degrees Fahrenheit for seven days; and
a support layer comprising a wall board, an insulation layer, and a covering layer, the support layer being substantially vertical relative to a floor when installed in a structure;
wherein the magnetic underlayment is secured to the support layer forming a combined magnetic surface assembly for receiving and supporting the set of modular wall covering units, and the set of modular wall covering units are adapted to be releasably secured to the combined magnetic surface assembly with the inner attractant layer facing the magnetic underlayment, and wherein the weight of the set of modular wall covering units, when installed in a vertical orientation, is supported by the combined magnetic surface assembly.

US Pat. No. 10,189,234

MACHINE AND MANUFACTURING METHOD FOR BUILDING BOARD

ONEDAY WALL AB, Orebro (...

1. A machine for finishing building boards which are essentially shaped as cuboids including a primary main side and opposite thereto a secondary main side each having a relatively large delimitation area and four edge sides each having a relatively small delimitation area, the machine comprising:a conveyor line configured to receive incoming body elements for building boards and transport the body elements in a working direction along a set of processing stations in the machine;
a first processing station of said set of processing stations comprises laterally operating processing means configured to, by gluing, apply a first edge strip, of a female type, along a first edge side of said four edge sides in such a manner that the first edge strip is brought in parallel with the primary main side; and
a second processing station of said set of processing stations comprises vertically operating processing means configured to:
apply, by gluing, a primary surface layer which covers the entire primary main side and the primary side of the first edge stripe, and thereafter
apply a vertical pressure over the body element and the first edge stripe across the working direction while the body element and the first edge stripe pass the second processing station in such a manner that the primary side of the first edge stripe is brought in level with the primary main side of the body element when passing through the second processing station.

US Pat. No. 10,189,231

FABRIC HAVING A WATERPROOF BARRIER

Columbia Sportswear North...

1. An article of clothing, body gear, sporting gear, gloves, headwear, or footwear, comprising:a base material having an inward-facing surface and an outward-facing surface;
an exposed, breathable, hydrophobic, waterproof barrier disposed on the outward-facing surface of the base material, the waterproof barrier having an exposed, outward-facing surface and an inward-facing surface directed toward the base material;
a seam running through the waterproof barrier; and
a waterproof tape bonded to the outward-facing surface of the waterproof barrier and oriented to seal the seam against water ingress.

US Pat. No. 10,189,224

METHODS FOR MAKING RUBBER BALES

Karltex Machine, Inc., O...

1. A method of forming a rubber bale, comprising:inserting, into a press chamber of a bale assembly, compressible rubber materials;
closing the press chamber;
compressing, in the press chamber, the compressible rubber materials with a bolster assembly to form a rubber bale, the bolster assembly including:
a first coupling portion;
a second coupling portion removably attached to the first coupling portion by one or more coupling bolts, the first coupling portion and the second coupling portion cooperatively defining an arc shaped cavity for receiving a hydraulic rod,
an island portion removably attached to the first coupling portion and the second coupling portion by a plurality of island bolts that run through either the first coupling portion, the second coupling portion, or both and into the island portion; and
a bolster cap removably attached to the island portion by a plurality of retainer bolts, the retainer bolts each including a non-circular head attached to a frustum, the head having a substantially planar surface, the frustum attached to a threaded shaft distal the head, the bolster cap including a plurality of countersunk bores that receive the retainer bolts, the countersunk bores having complementary shapes to those of the retainer bolts;
opening the press chamber; and
ejecting the rubber bale from the press chamber.

US Pat. No. 10,189,214

FREESPACE COMPOSITE MANUFACTURING PROCESS AND DEVICE

Composite Cluster Singapo...

1. A movable apparatus for forming a thermo-softening part, the apparatus comprising:a stationary base structure of the thermo-softening part, the stationary base structure defining a first side and a second side disposed opposite from the first side
a first placement unit that comprises:
at least one first roller, the first roller configured to move in a first predetermined path conforming to the first side of the stationary base structure of the thermo-softening part, and
a first heat source, and
a second placement unit that comprises at least one second roller, which corresponds to the at least one first roller, the second roller configured to move in a second predetermined path conforming to the second side of the stationary base structure, and
wherein:
the first heat source is provided for heating an elongated thermo-softening material to a predetermined temperature, and
the at least one first roller and the at least one second roller are configured to compress the thermo-softening material and the stationary base structure, the at least one first roller configured to press the thermo-softening material to the first side of the stationary base structure, the at least one second roller configured to press against the second side of the stationary base structure opposite from the at least one first roller.

US Pat. No. 10,189,213

METHOD AND MANUFACTURING UNIT FOR PRODUCING FIBER COMPOSITE MATERIAL COMPONENTS

Broetje-Automation GmbH, ...

1. A method for producing fiber composite material components comprising the following steps:providing a manufacturing unit to apply a fiber composite material to a component mould,
wherein the manufacturing unit has a positioning device and an application tool arranged thereon,
wherein the positioning device comprises a robot which has at least four pivot axes for the application tool,
wherein the positioning device to position the application tool relative to the component mould has a plurality of drive motors, which are activatable by a control device, the plurality of drive motors comprising a drive motor associated with each of the at least four pivot axes, and
wherein the manufacturing unit has at least two height profile measuring sensors, each with a detection range directed onto the component mould;
applying a first web of the fiber composite material to the component mould;
measuring a height profile in such a way that at least a part of the applied first web is located in the detection range of one of the height profile measuring sensors; and
applying a second web of the fiber composite material to the component mould in such a way that the control device activates at least one of the drive motors depending on the measured height profile, wherein the control device is operable to activate the at least one of the drive motors based on only one of the at least two height profile measuring sensors;
wherein the first and second webs are applied in opposite application directions,
wherein the at least two height profile measuring sensors comprise a first height profile measuring sensor and a second height profile measuring sensor arranged next to one another on the application tool such that the detection range of the first height profile measuring sensor is spaced apart from the detection range of the second height profile measuring sensor during application of the first and second webs;
wherein the first height profile measuring sensor measures a height profile of a previously applied web when the application tool is traveling in a first direction;
wherein the second height measuring sensor measures a height profile of a previously applied web when the application tool is traveling in a second direction;
wherein the application tool is rotated through 180° relative to the positioning device upon a change in the application direction;
wherein at least a part of a previously applied web is located in the detection range of one of the first and second height profile measuring sensors and not in the detection range of the other of the first and second height profile measuring sensors when the application tool is traveling in each of the first and second directions; and
wherein each of the first and second height profile measuring sensors is configured as a light section sensor configured to contactlessly measure the height profile of a previously applied web using a light section method comprising projecting a light line on the previously applied web and detecting a reflection of the light line, wherein the light line projected by each of the first and second height profile measuring sensors defines the detection range of each respective height profile measuring sensor.

US Pat. No. 10,189,212

POROUS STAMP MATERIAL FOR LASER PROCESSING, POROUS STAMP USING THE SAME, AND METHOD OF MANUFACTURING THE SAME

Glory Industry Co., Ltd.,...

1. A porous stamp material consisting of a porous substance having continuous pores having 10-60 ?m pore diameter and comprising a non-crosslinked thermoplastic resin and 50-250 parts by weight of hydroxylated compound with respect to 100 parts by weight of the thermoplastic resin, wherein the starting temperature of dehydration of the hydroxylated compound is 100 to 500° C.

US Pat. No. 10,189,211

METHOD FOR PROCESSING ADDITIVELY MANUFACTURED PART BY ROBOTICALLY MOVING MEDIUM INSIDE PART CAVITY

Incodema3D, LLC, Freevil...

1. A method, comprising:A method, comprising:
receiving, by a computer system, a three dimensional (3D) definition of a build piece from which a build plan has been derived, the 3D definition comprising a plurality of connected internal cavity sections;
generating, by the computer system, based on the 3D definition, a processing plan that comprises a plurality of robotic instructions to successively robotically move the build piece created by an additive manufacturing process into successive orientations in space, such that:
for each particular connected internal cavity section:
there is one of the successive orientations in the processing plan that corresponds to the particular connected internal cavity section;
the robotic instructions for robotic movement for the corresponding particular internal cavity section are created to ensure that the build piece is moved so that one surface of the corresponding particular connected internal cavity section and a horizontal plane in the space define an angle of constant value, wherein the angle is great enough to cause at least one medium inside the particular connected internal cavity section to have a polishing effect due to the force of gravity moving the medium along the length of the corresponding particular connected internal cavity section, wherein the constant value is the same value for all connected internal cavity sections; and
wherein the robotic instructions to successively orient a build piece into successive orientations specify a plurality of durations, each successive orientation having a corresponding duration at which the build piece is to be held at the successive orientation for a length of the corresponding duration;
outputting, by the computer system, the processing plan for use by a robotic controller;
inputting, by a robotic controller, the processing plan; and
causing, by the robotic controller, a robotic manipulator to execute the processing plan.

US Pat. No. 10,189,205

PRINTER HEAD Z-AXIS ALIGNMENT METHOD AND SYSTEM

NORTHWORKS AUTOMATION, IN...

1. A z-axis calibration system for a three-dimensional printer comprising:a controller determining a zero position for a three-dimensional printer printhead in an x-axis and a y-axis, as well as finding an initial position for position of the printhead in the z-axis;
a hotend of the printhead for deposition of printing material, the hotend connected to the printhead via a connector moveable in the z-axis, the hotend including an arm extending outward therefrom;
an optical sensor assembly including an emitter and a detector, the optical sensor assembly directly affixed to the printhead, where at the initial position in the z-axis, the arm of the hotend extends in-between the emitter and the detector; and
wherein the controller calibrates a starting position for the printhead based on z-axis movement of the printhead distinct from the hotend as facilitated by the connector, causing z-axis displacement of the arm on the hotend, the z-axis displacement allowing the detector to detect a change in light from the emitter.

US Pat. No. 10,189,194

UNITARY DIAPHRAGM

Zurn Industries, LLC, Mi...

1. A one-piece unitary diaphragm assembly for use in a flush valve, the assembly comprising:an elongated barrel member having a body defining a passageway;
an annular flexible diaphragm disposed about the elongated barrel member, and a mounting portion at the peripheral edge of the annular flexible diaphragm for mounting said diaphragm assembly within the flush valve;
a radial support positioned circumferentially around the outer surface of said barrel member and extending along at least a portion of the longitudinal length of said barrel member;
a relief valve seat at the upper end of said elongated barrel member, said relief valve seat adapted for receiving a relief valve; and
a relief valve having a stem and a sealing member disposed at an upper end of said stem, in which a sealing material is disposed on a lower surface of the sealing member adapted for sealing against said relief valve seat;
wherein the sealing material is an annular lip on the lower surface of the sealing member;
wherein the elongated barrel member is constructed of a first predetermined material; and
wherein the annular flexible diaphragm is constructed of a second predetermined material different from the first predetermined material.

US Pat. No. 10,189,191

COLLECTION OF PROCESS DATA USING IN-SITU SENSORS

THE BOEING COMPANY, Chic...

1. A system for molding a composite layup inside an autoclave, comprising:a mold tool;
a vacuum bag sealed to the mold tool and having a plurality of openings therein at different sensing locations on the vacuum bag;
a plurality of first MEMS vacuum pressure sensors attached to the vacuum bag and respectively coupled through the openings to an interior of the vacuum bag;
at least one opening in the mold tool;
a second MEMS vacuum pressure sensor mounted within the opening in the mold tool and configured to sense either a vacuum pressure or a fluid pressure inside the at least one opening in the mold tool; and
a processor configured to be placed inside the autoclave and to collect and process pressures sensed by the plurality of first MEMS vacuum pressure sensors and the second MEMS vacuum pressure sensor.

US Pat. No. 10,189,188

NANOIMPRINT LITHOGRAPHY ADHESION LAYER

Canon Kabushiki Kaisha, ...

1. A compound of Formula A-1:
wherein n is an integer and R is C1-10 alkyl.

US Pat. No. 10,189,182

PROCESSING SYSTEM

DISCO Corporation, Toky...

1. A processing system comprising:a processing apparatus having functional units including a holding unit that holds a workpiece by a holding surface, a processing unit that processes the workpiece held by the holding unit, and a feed unit that moves the holding unit and the processing unit relatively;
a detecting unit that is provided for part or all of the functional units and detects any of vibration, current, voltage, load, speed, torque, pressure, temperature, flow rate, change in a taken image, and thickness of the workpiece; and
a data accumulating unit that accumulates information included in a signal output from the detecting unit as accumulated data,
the processing apparatus further comprising,
a determining unit that determines states of the functional units on the basis of the accumulated data in the data accumulating unit, and
a normal data storing unit that stores information included in a signal output from the detecting unit when the functional units are normal based on a predetermined condition as normal data;
the determining unit comparing the accumulated data in the data accumulating unit and the normal data stored in the normal data storing unit and determining the states of the functional units,
wherein the processing apparatus is a cutting apparatus including, as the processing unit, a cutting unit in which a cutting blade that carries out cutting processing of the workpiece held by the holding unit is mounted,
the cutting apparatus includes a vibration detecting unit that detects vibration of the cutting blade as the detecting unit,
information on vibration when cutting processing of the workpiece is carried out by the cutting blade is accumulated in the data accumulating unit as the accumulated data,
information on vibration when cutting processing of the workpiece is carried out by a proper cutting blade corresponding to the workpiece is stored in the normal data storing unit as the normal data, and
the determining unit compares the accumulated data in the data accumulating unit and the normal data stored in the normal data storing unit and determines whether or not cutting processing of the workpiece is normally carried out.

US Pat. No. 10,189,180

FOAM INJECTION SYSTEM WITH VARIABLE PORT INSERTS FOR SLURRY MIXING AND DISPENSING APPARATUS

United States Gypsum Comp...

1. A foam injection system for a cementitious slurry mixing and dispensing assembly, the foam injection system comprising:a foam injection body, the foam injection body defining a slurry passageway and a first port passageway, the first port passageway having a port opening in fluid communication with the slurry passageway, the foam injection body including a body engaging surface;
a first port insert, the first port insert defining a first foam passageway having a first orifice with a first orifice size, the first port insert adapted to removably mount to the foam injection body such that the first foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway, the first port insert including a port insert engaging surface adapted to engage the body engaging surface of the foam injection body when the first port insert is mounted thereto such that the first foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway; and
a second port insert, the second port insert defining a second foam passageway having a second orifice with a second orifice size, the second port insert adapted to removably mount to the foam injection body instead of the first port insert such that the second foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway, and the second orifice size being different than the first orifice size, the second non insert including the port insert engaging surface such that the port insert engaging surface of the second port insert is adapted to engage the body engaging surface of the foam injection body when the second port insert, instead of the first port insert, is mounted to the foam injection body such that the second foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway.

US Pat. No. 10,189,151

COMPACT HEAD BODY HAMMER

Snap-on Incorporated, Ke...

1. A tool comprising:a head having a base and a face extending from the base, wherein the face is adapted to strike an object when the tool is used, the head includes a head centerline extending through a center portion of the base; and
a handle having a handle centerline extending through a central axis of the handle,
wherein the head centerline is axially offset relative to the handle centerline.

US Pat. No. 10,189,130

MACHINE TOOL

DMG MORI CO., LTD., Yama...

1. A machine tool having a tool changer, comprising:a tool holding part holding a plurality of tools; and
a tool change mechanism changing a tool held by the tool holding part and a tool clamped by a spindle,
wherein the tool holding part is positioned in a side of the spindle to hold the plurality of tools in a manner in which axes of the tools are parallel to an axis of the spindle,
the tool change mechanism includes a circular arc movement mechanism,
the circular arc movement mechanism moves the tools from a tool holding position to a tool change position at which the tool is coaxial with the axis of the spindle, by at least a circular arc movement on a plane on which the axis of the spindle positioned in the tool change position and an axis of the tool positioned in the tool holding part are arranged,
the tool position is different for each of the tools,
a dividing wall is formed between the tool change mechanism and the spindle,
the dividing wall includes an opening which is closed by a shutter, and
the circular arc movement mechanism moves the tools in the circular arc movement through the opening when the shutter opens the opening.

US Pat. No. 10,189,120

WELDING WIRE FOR FE—36NI ALLOY

APERAM, Luxembourg (LU)

1. Welding wire intended to be used for welding together portions of parts, which portions have the following composition in wt. %:35.0%?Ni?37.0%
trace?C?0.10%
trace?Mn?0.60%
trace?P?0.025%
trace?S?0.025%
trace?Si?0.35%
trace?Cr?0.50%
trace?Mo?0.50%
trace?Co?0.50%
the rest consisting of iron and inevitable impurities resulting from production,
wherein the welding wire is made in an alloy comprising, in wt. %:
38.6%?Ni+Co?45.0%
trace?Co?0.50%
2.25%?Ti+Nb?0.8667×(Ni+Co)?31.20% if 38.6%?Ni+Co?40.33%
2.25%?Ti+Nb?3.75% if 40.33%?Ni+Co?41.4%
0.4167× (Ni+Co)?15.0%?Ti+Nb?3.75% if 41.4%?Ni+Co?45.0%
trace?Nb?0.50%
0.01%?Mn?0.30%
0.01%?Si?0.25%
trace?C?0.05%
trace?Cr?0.50%
the rest consisting of iron and inevitable impurities resulting from production.

US Pat. No. 10,189,105

SHIELDING GAS FOR MAG WELDING, MAG WELDING METHOD, AND WELDED STRUCTURE

TAIYO NIPPON SANSO CORPOR...

1. A MAG welding method, comprising:preparing a pair of base materials which are made of a high Cr steel containing 8 wt % to 13 wt % of Cr and arranged to have a narrow gap between them; and
performing arc welding of the pair of base materials by using a shielding gas being a ternary mixed gas consisting essentially of 15% by volume to 17% by volume of a carbon dioxide gas, 30% by volume to 50% by volume of a helium gas and a balance of an argon gas, and a solid wire containing 8 wt % to 13 wt % of Cr.

US Pat. No. 10,189,066

WHEEL STRAIGHTENER DEVICE

GAHOTECH SISTEMAS AUTOMOT...

1. A WHEEL STRAIGHTENER DEVICE, comprising:a main column (110);
a flange (111) mounted on an end of the main column (110) for fixing a wheel;
a measuring rod (116) mounted on the same end of the main column (110) and arranged above the flange (111);
a guide (118) mounted on the same end of the main column (110), a single piece body (115) being movably mounted on the guide (118), and a bearing (114) mounted on a top end of the single piece body (115), the bearing (114) having a geometric shape matching with a shape of an inner region of the wheel for supporting the wheel, wherein the single piece body (115) moves along the guide (118) to approach or move away from the wheel positioned on the flange (111);
a tubular extension (113) formed on a central portion of the main column (110) and perpendicular to the main column (110);
a second tubular extension (120), portion of which is inserted into an end portion of the tubular extension (113) and perpendicular to the main column (110);
a tubular piece (121) mounted on an end of the second tubular extension (120) and being perpendicular to the second tubular extension (120);
a third tube segment (132) being movably inserted into the tubular piece (121) and being parallel to the main column (110);
a piston hydraulic means (130) being mounted on an upper end of the third tube segment (132) and connected to a hydraulic pump (117), which is mounted on the main column (110), by means of hoses (119);
wherein the flange (111) has a central bore, and a plurality of radial oblong holes for matching with drill pattern of the wheel, wherein the plurality of radial oblong holes includes three sets of radial oblong holes, a first set of radial oblong holes (I) includes radial oblong holes (I) spaced evenly with 72° between each pair of adjacent radial oblong holes (I) starting from a reference hole (I, II, III), a second set of radial oblong holes (II) includes radial oblong holes (II) spaced evenly with 90° between each pair of adjacent radial oblong holes (II) starting from the reference hole (I, II, III), and a third set of radial oblong holes (III) includes radial oblong holes (III) spaced evenly with 120° between each pair of adjacent radial oblong holes (III) starting from the reference hole (I, II, III), thus the radial oblong holes of the three sets of radial oblong holes are positioned alternately on the flange (111).

US Pat. No. 10,189,058

APPARATUS FOR REMOVING CHIPS FROM INTERIOR OF PIPE USING PRESSURE DIFFERENCE

DONGHWA INDUSTRY CO., LTD...

1. An apparatus for removing chips from an interior of a pipe, having a fitting mounted to a region adjacent to a hole bored in the pipe, through which high-pressure fluid flows, and a sandwich valve coupled to the fitting, the apparatus comprising:a chip-removing adapter mounted above the sandwich valve;
a suction tube extending to an inner surface of the pipe through the chip-removing adapter in order to remove chips deposited in the pipe;
a vertical moving unit for vertically moving the suction tube;
a delivery tube connected to an upper end of the suction tube and configured to deliver the chips to a predetermined place; and
a strainer mounted to a distal end of the delivery tube in order to separate the delivered chips from the fluid;
wherein a lower end of the suction tube comprises a suction tip having a funnel shape and a suction plate is coupled to the suction tip, wherein the suction plate is formed to be curved corresponding to a curved inner surface of the pipe; and
wherein the suction tube is provided with a stopper for limiting a downward moving distance of the suction tube, the stopper being mounted to a portion of the suction tube that is exposed outside the chip-removing adapter.

US Pat. No. 10,189,055

COLOR BASED OPTICAL GRADING SYSTEM WITH MULTI REFLECTANCE AND MULTI-ANGLE VIEWS

NANOPIX INTEGRATED SOFTWA...

1. A novel color based optical grading system with multi-reflectance and multi-angle views for grading objects of different external characteristics, said optical grading system comprising of multiple advanced optics units which are placed above and below a flat transparent conveyor which is an arrangement of multiple trays forming multiple trays, where each tray is an assembly of multiple flat transparent surfaces with facility for multi-vision of single object in a single flat transparent surface in a pre-defined position; and at least one master controller; wherein the arrangement of said multiple advanced optics units above and below the conveyor is always kept in a way so as to provide exactly two advanced optics units for covering both top and bottom sides of each object to be graded; and wherein each advanced optics unit comprises of:multiple programmable cameras which are placed at a specific distance from said flat transparent surface and said multiple cameras are adapted to capture different views of each object at different frequencies of electromagnetic spectrum and to get a proper focus of said flat transparent surface;
multiple mirrors/multiple prisms to get redirected light reflected from side views of each object to said cameras which enable said multiple cameras to capture multi-reflectance and multi-angle based views of said object to analyze said object and said multiple mirrors/prisms also enables said cameras to get a proper focus of reflections of said multiple mirrors/prisms and said object;
at least one mirror/prism adjustment assembly to adjust the angles of said multiple mirrors or multiple prisms relative to the position of said object on said flat transparent surface; to adjust said mirrors/prisms according to size variations of multiple objects; and to vary vertical or horizontal distance of said mirrors/prisms from said flat transparent surface;
multiple spectral light sources to illuminate every side view of said object at different frequencies of electromagnetic spectrum, wherein said spectral light sources are correlated with all said cameras and said light sources is either flash lighting or continuous lighting, and some of said light sources are triggered with some respective cameras while others light sources are turned off as per the requirement;
at least one backlighting dome placed exactly opposite of each advanced optics unit, wherein said each backlighting dome is arranged in said optical grading system in such a way that there lays at least one flat transparent surface between each said backlighting dome and each advanced optics units to provide uniform backlight for capturing objects in multi-reflection and multi-angle based views and said backlighting dome comprises of multi-colored, flashing or non-flashing back lights, wherein said backlighting dome is optionally covered with a diffusion sheet which is adapted to change in color of said sheet according to different characteristics of said object; and
at least one image processing unit for processing multi-reflectance and multi-angle based views of said object taken by said cameras; wherein said multiple cameras said multiple spectral light sources, said multiple adjustable mirrors/multiple adjustable prisms, said mirror adjustment assembly, said backlighting dome and said image processing unit work collaboratively to ensure the enhanced surface analysis of said object, and further wherein said advanced optics unit enhances the sideways features of said objects including sideways lighting from different sides using multiple reflections from multiple angles by enabling said multiple cameras to analyze said object from all side views and also from top and bottom views for accurate complete analysis of said object; wherein said master controller of said optical grading system intelligently remembers the position of each said object dropped on each flat transparent surface of each tray and decide the final grade of each said object based on inputs received from each image processing unit of corresponding each advanced optics unit by comparing said inputs with pre-determined data.

US Pat. No. 10,189,054

DEVIATION HANDLING APPARATUS AND DEVIATION HANDLING METHOD

Freund Corporation, Toky...

1. A deviation handling apparatus to be used for a continuous production system of granulated products used for pharmaceutical products, foods and fertilizers in order to discharge granulated products not meeting predetermined product specifications out of the system, the deviation handling apparatus comprising:a storage section for temporarily storing granulated products;
an inspection section for inspecting selected physical properties of the granulated products in the storage section;
a discharge path arranged downstream relative to the storage section to discharge the granulated products to outside of the continuous production system; and
a switching section for switching a moving route of the granulated products according to a result of the inspection by the inspection section so as to guide the granulated products judged as not meeting the predetermined product specifications to the discharge path, wherein
the storage section is arranged on a conveyance route for conveying the granulated products in the continuous production system and has a first valve capable of shutting off the conveyance route, a second valve capable of shutting off the conveyance route, the second valve being located downstream relative to the first valve, and a storage chamber formed between the first valve and the second valve to store the granulated products,
the first valve and the second valve each have a closed position for shutting off the conveyance route and an open position for opening the conveyance route, wherein as the first valve and the second valve are placed into the respective closed positions, the conveyance route is closed and the storage chamber is sealed, thereby producing a hermetically sealed storage chamber in the storage section,
the inspection section is arranged so as to face the storage chamber and measure the selected physical properties of the granulated products stored in the storage chamber, and
the switching section is arranged at a diverging portion of the discharge path and the conveyance route and has a switching valve having a first position for causing the conveyance route to communicate with a downstream side of the continuous production system and a second position for closing a downstream side of the conveyance route and causing the conveyance route to communicate with the discharge path.

US Pat. No. 10,189,038

INDUCTIVELY HEATABLE FLUID RESERVOIR FOR VARIOUS FLUID TYPES

Toaster Labs, Inc., Seat...

1. A fluid delivery pod comprising:a first surface;
a second surface that opposes the first surface;
a reservoir body intermediate the first and the second surfaces, wherein the reservoir body is configured to house a fluid;
an outlet port in fluid communication with the reservoir;
a heating structure within the reservoir body and being electrically conductive to wirelessly receive inductive energy from an energy source that is external to the fluid reservoir to heat at least a portion of the fluid within the reservoir body; and
a valve assembly that is operative to, in response to an application of compression forces on the opposing first and the second surfaces, dispense at least a portion of the heated fluid through the outlet port;
wherein the first surface further comprises a piston that translates along at least a portion of the reservoir body.

US Pat. No. 10,189,035

MACHINE FOR MIXING AND SUCCESSIVELY APPLYING SEALANT MATERIAL

Airbus Defence and Space ...

1. A machine for mixing and successively applying a bi-component sealing material formed by mixing a base and a hardener in a pre-established ratio comprising:storage tanks including a first storage tank for the base and a second storage tank for the hardener;
metering chambers including:
a first metering chamber for the base and having an inlet connected to a first inlet hose extending from the first storage tank, and
a second metering chamber for the hardener and having an inlet connected to a second inlet hose extending from the second storage tank,
wherein a first volume of the first metering chamber and a second volume of the second metering chamber are related such that a volumetric ratio of the first and second volumes conforms to a desired volumetric ratio of a mixture of the base and the hardener;
a pushing device including:
a first piston in the first metering chamber and configured to push the base from the first metering chamber and through a first outlet of the first metering chamber, and
a second piston in the second metering chamber and configured to push the hardener from the second metering chamber and through a second outlet of the second metering chamber;
wherein the pushing device comprises an actuator configured to move the first and second pistons at displacement speeds determined by a control system to push the base from the first metering chamber and the hardener from the second metering chamber;
an applicator device including a mixing head having inlets each connected to a respective one of the first and second outlets of the first and second metering chambers, a static mixer configured to mix the hardener and base flowing from the first and second metering chambers, and a third outlet through which a mixture of the hardener and base flows from the static mixer; and
at least two flow measurement devices configured to measure a flow of the base and a flow of the hardener from the first and second outlets,
wherein the control system is configured to vary the displacement speeds of said first and second pistons so that a ratio of the flows of the hardener and the base from the first and second outlets conforms to a pre-established ratio of the base and the hardener based on weight or volume of the base and the hardener,
wherein the control system, while the pushing device pushes the first and second pistons, repeatedly: (i) receives data from the at least two flow measurement devices indicative of the flows from the first and second metering chambers of the base and the hardener, (ii) calculates the displacement speeds for each of the first and second pistons based on the received data, and (iii) applies the calculated displacement speeds to command the pushing device to move the first and second pistons at their respective displacement speeds.

US Pat. No. 10,189,027

HIGH CAPACITY SEPARATION OF METALS FROM AUTO SHREDDER RESIDUE

SA Recycling LLC, Orange...

1. A method for separating automobile shredder residue (ASR) pieces in an aquatic separator for separating the pieces over time, the method comprising:providing an aquatic separator with a container defining a lower portion with a circular cross section whose walls converge at a lower end, and an upper portion which is substantially cylindrical, the container further having an open top mouth larger than a lower outlet at the lower end and a paddle suspended across the open top mouth and depending down into an interior of the container, the paddle configured to rotate in a direction of rotation about a central axis of the container and having vanes that are spaced from an interior wall of the container and stir ASR pieces and water within the container;
introducing in an input stream a mixture of ASR pieces of varying specific gravity and water directly into the open top mouth of the container;
stirring the ASR pieces and the water in the container in a first direction of rotation about a central axis, wherein heavier pieces of specific gravity greater than that of the water tend to sink and the lighter pieces of specific gravity less than that of the water tend to rise, which separates the pieces into primarily heavier metals and primarily lighter non-metals;
injecting water into the container via at least one inlet in a side wall of the container generally parallel to the direction of rotation;
removing a majority of the heavier pieces from the container through the lower outlet of the container in a lower output stream; and
removing a majority of the lighter pieces from the container through an upper outlet in one side of the container in an upper output stream.

US Pat. No. 10,189,014

SOLID PHOSPHORIC ACID CATALYSTS

Clariant Corporation, Lo...

1. A calcined solid phosphoric acid catalyst composition comprising:one or more phosphoric acids;
one or more silicon phosphates;
optionally, one or more additional inorganic phosphates; and
optionally, a siliceous support material,
wherein the amount of phosphate in the calcined solid phosphoric acid catalyst composition is within the range of about 30 wt. % to about 85 wt. %, calculated as P2O5 on a calcined basis; and
the amount of silicon in the calcined solid phosphoric acid catalyst composition is within the range of about 15 wt. % to about 70 wt. %, calculated as SiO2on a calcined basis; and
wherein
(i) the calcined solid phosphoric acid catalyst composition includes one or more promoters each selected from the group consisting of boron, bismuth, tungsten, silver, and lanthanum, present in an amount within the range of about 0.015 wt. % to about 5 wt. %, calculated as oxide on a calcined basis;
(ii) the calcined solid phosphoric acid catalyst composition is the calcined product of a mixture comprising one or more of a silica-alumina clay, a silica fiber material and a silica-alumina fiber material, present in the mixture in an amount within the range of about 0.1 wt. % to about 15 wt. % on a calcined basis; or
(iii) the calcined solid phosphoric acid catalyst composition is the calcined product of a mixture comprising fumed silica, present in the mixture in an amount within the range of about 0.1 wt. % to about 15 wt. % on a calcined basis.

US Pat. No. 10,188,996

POWDER MIXING APPARATUS AND METHOD OF USE

Adamis Pharmaceuticals Co...

1. A powder mixing apparatus comprising:a first powder input portion comprising a first dispensing device;
a venturi tube;
a first mixing portion comprising a first powder inlet, a first gas inlet, and
a first mixing cavity;
wherein the first dispensing device comprises a first opening configured to dispense a first premixed powder through the venturi tube and into the first mixing portion;
wherein the first premixed powder comprises at least two micronized powders;
wherein the first gas inlet is configured to provide a first flow of a pressurized gas into the first mixing cavity; and
wherein the gas and the first premixed powder interact in the first mixing cavity to form a first post-mixed powder.

US Pat. No. 10,188,994

METHOD, APPARATUS AND SYSTEM FOR AFTERTREATMENT OF EXHAUST GAS

PROVENTIA OY, Oulunsalo ...

1. An apparatus for aftertreatment of exhaust gas comprising:a housing configured to define an inner cavity;
an exhaust inlet arranged to the housing for entering exhaust gas to the inner cavity;
a first flow guide in the inner cavity configured to guide at least part of the exhaust gas to a first direction to form a first direction flow, the first flow guide comprising:
an elongated blade extending across the inner cavity; and
a perforated tubular element, wherein at least part of the exhaust gas is configured to enter an interior of the perforated tubular element through apertures, the perforated tubular element being configured to guide the exhaust gas to a circulating and advancing movement in a first direction,
the first flow guide in the inner cavity is configured to form, using the exhaust gas, a center flow and an edge flow circulating and advancing around the center flow in the first direction;
a reactant inlet arranged to the housing for dispensing reactant to the first direction flow in the inner cavity, the reactant configured to mix with the exhaust gas, wherein mixing of the reactant and the exhaust gas occurs within center flow in the first direction flow, the second direction flow and the third direction flow, and the center flow is advancing inside the perforated tubular element in the first direction and the edge flow is circulating and advancing around the perforated tubular element in the first direction;
a second flow guide in the inner cavity located downstream from the first flow guide, the second flow guide configured to:
guide at least a part of the first direction flow to a second direction to form a second direction flow, wherein the second direction being opposite to the first direction; and
guide the second direction flow to a third direction to form a third direction flow, wherein the third direction being downstream to the second direction and parallel to the first direction; and
an exhaust outlet arranged to the housing for exiting output exhaust gas from the inner cavity, the exhaust outlet being downstream to the second flow guide,
wherein mixing of the reactant and the exhaust gas occurs within the first direction flow, the second direction flow and the third direction flow;
a solid tubular element downstream to the perforated tubular element and upstream to the second flow guide, configured to guide at least part of the first direction flow towards the second flow guide, wherein a diameter of the solid tubular element being greater than a diameter of a second end of the perforated tubular element and allowing a part of the circulating and advancing edge flow around the perforated tubular element to enter the solid tubular element.

US Pat. No. 10,188,990

DEVICE AND METHOD FOR POSITIONING A DETONATOR WITHIN A PERFORATING GUN ASSEMBLY

DynaEnergetics US, Inc., ...

1. A detonator positioning device for positioning a wireless detonator in a perforating gun assembly, the device comprising:a cylindrical body comprising an open end, a closed end, and a central bore adapted for receiving the detonator, the central bore extending along at least some of a length of the cylindrical body, the central bore including an enlarged bore portion adjacent the open end of the cylindrical body;
a plurality of arms extending toward the open end of the cylindrical body and at least partially enclosing the enlarged bore portion of the central bore, each of the plurality of arms adapted to retain a detonator head of the detonator when the detonator is positioned within the enlarged bore portion of the central bore; and
a plurality of legs extending from the cylindrical body and toward the closed end of the cylindrical body, each of the plurality of legs adapted to position the cylindrical body in the perforating gun assembly.

US Pat. No. 10,188,985

ZEOLITE AND REDOX OXIDE COMBINED CATALYST BODY

Corning Incorporated, Co...

1. A method for treating an exhaust stream containing NOx gas comprising contacting a catalytic structure with the exhaust stream, the catalytic structure comprising a first oxide selected from the group consisting of tungsten oxides and vanadium oxides, a second oxide selected from the group consisting of cerium oxides, lanthanum oxides, zirconium oxides, and combinations thereof, and a zeolite, the method further comprising contacting the catalytic structure with the exhaust stream containing NOx gas, wherein the catalytic structure is substantially free of platinum, palladium, and rhodium, and wherein an external layer of the catalytic structure comprises a mixture of the first oxide and the second oxide without the zeolite on a layer comprising the zeolite.

US Pat. No. 10,188,980

COAL UPGRADE PLANT AND METHOD FOR MANUFACTURING UPGRADED COAL

MITSUBISHI HEAVY INDUSTRI...

1. A coal upgrade plant comprising:a dryer for heating and drying coal before pyrolyzing the coal;
a scrubber for treating a carrier gas discharged from the dryer while catching a desorbed component desorbed from the coal when the coal is dried by the dryer, and causing at least one of mercury and mercury-based substances contained in the carrier gas to be adsorbed to an absorber for removal thereof;
a waste water treatment equipment for separating waste water collected from the scrubber into a solid content and recycled water;
a water demanding section for using the recycled water treated in the waste water treatment equipment; and
a carrier gas cooler that is provided on an upstream side of the scrubber to cool the carrier gas discharged from the dryer by using cooling water,
wherein the water demanding section is a cooling water feed section that feeds the cooling water to the carrier gas cooler, and uses the recycled water as the cooling water.

US Pat. No. 10,188,976

AIR PURIFIER, METHOD FOR DETERMINING TIME TO REPLACE FILTER THEREOF, AND DEVICE AND METHOD FOR DETERMINING FILTER REPLACEMENT TIME PRESSURE DIFFERENTIAL THEREFOR

COWAY CO., LTD., Chungch...

1. An air purifier comprising:a memory storing flow rate/differential pressure correlation graphs according to respective filter usage states;
a differential pressure sensor measuring differential pressure as a pressure difference between a front end of the filter and a rear end of the filter; and
a filter replacement time management unit determining a time to replace the filter according to a result of matching a differential pressure of the filter measured by a differential pressure sensor in every preset period and a flow rate of air introduced to the filter at the time of measuring the differential pressure to the flow rate/differential pressure correlation graph according to each usage state;
wherein the memory stores flow rate/differential pressure correlation graphs regarding a plurality of filters, identifies a filter having a graph matched to an initial differential pressure measured by the differential pressure sensor at an initial installation stage and a flow rate of air introduced to the filter at the time of measuring the initial differential pressure on the basis of a flow rate/differential pressure graph of an initial usage stage regarding a plurality of filters, selects a flow rate/differential pressure correlation graph of a replacement time state of the identified filter, and use the selected graph in determining a time to replace the filter.

US Pat. No. 10,188,974

AGGREGATE-REMOVING FILTER MATERIAL, AGGREGATE REMOVAL METHOD, WHITE BLOOD CELL-REMOVING FILTER, AND BLOOD PRODUCT FILTERING METHOD

ASAHI KASEI MEDICAL CO., ...

1. An aggregate-removing filter material for removing an aggregate in a blood product, the filter material consisting of fibers having a fineness of 0.7 to 4.0 dtex,wherein a basis weight of the filter material is 20 to 100 g/m2, a no-load bulk density of the filter material is 0.03 to 0.10 g/cm3, and at least 70% of the fibers have a fiber length of 100 mm to 1000 mm.

US Pat. No. 10,188,957

TOY WITH PROXIMITY-BASED INTERACTIVE FEATURES

Mattel, Inc., El Segundo...

1. A toy comprising: a photosensor;a memory comprising at least one mapping of a plurality of sequential ranges of input states to a plurality of discrete output states;
at least one input signal pathway operably connected to the photosensor;
a microprocessor operably connected to the photosensor through a plurality of input signal pathways, the microprocessor operable to:
select one of the input signal pathways as an active signal pathway,
receive an input signal from the photosensor through only the active signal pathway,
determine that the input signal falls within one of the ranges of input states,
use the at least one mapping to correlate the input state range in which the input signal falls with a selected one of the plurality of discrete output states; and
produce an output signal corresponding to the selected output state; and an output mechanism configured to receive the output signal from the microprocessor and to generate an output corresponding to the selected output state; wherein the memory, the at least one input signal pathway, and the microprocessor are all within the toy.

US Pat. No. 10,188,956

ASSEMBLY-TYPE EVOLUTIONARY GAME SYSTEM

ORGANIC CONSTRUCTION SYST...

1. An assembly-type evolutionary game system comprising the following components:a) extendable components of a base body which comprise:
a body abdomen-side part (8);
a first body back-side part (9);
a second body back-side part (10);
a third body back-side part (11);
a fourth body back-side part (12);
a fifth body back-side part (13); and
a sixth body back-side part (14);
wherein the extendable components include an internal extension metal array to extend and adjust proportions of the extendable components,
b) malleable structural joint pieces of the base body which comprise:
a short straight connection structural joint piece (1) with an end comprising a straight connection piece;
a middle straight connection structural joint piece (5) with an end comprising a straight connection piece;
a long straight connection structural joint piece (7) with an end comprising a straight connection piece;
a middle spherical connection structural joint piece (3) with an end comprising a spherical connection piece;
a long spherical connection structural joint piece (6) with an end comprising a spherical connection piece;
a mixed connection structural joint piece (2) with an end comprising a straight connection piece; and
a hand structural joint piece (4) including a hand connection piece;
wherein the malleable structural joint pieces are configurable to hold a shape after adjustment, and
c) rigid components of the base body which comprise:
a plurality of separate body parts, wherein each separate body part encloses a hollow portion and at least one clamp located at a curved portion of the body part and extending inwardly into the enclosed hollow portion within each separate body part, the plurality of separate body parts comprising:
a narrow rib (15);
a narrow limb connection main body (16);
a flat rib (18);
a flat limb connection main body (19),
wherein each of the plurality of separate body parts is configured to connect to at least one of the malleable structural joint pieces extending through the hollow portion using the at least one clamp thereon;
a plurality of additional rigid components comprising:
a thigh (17);
a knee (20);
an ankle (21);
a foot (22);
a wing (23);
a shin (24);
a fish tail piece (25) or a single tail piece (26);
a reptile head (27) or a fish head (29) comprising a skull and a jaw;
a crest (28);
a head connection component (30);
a front arm (31);
an elbow and wrist component (32); and
an arm (33),
wherein the extendable components connect to the malleable structural joint pieces, and
wherein coupling the components enables a formation of assembled components to create a diverse number of animals.

US Pat. No. 10,188,949

GAME OBJECT CONTROL SYSTEM AND PROGRAM

EARTHBEAT, INC., Shibuy-...

1. A game object control system which invokes various event processes to progress a game in a virtual world where a character corresponding to a user and other objects move, comprising:a game progress processing unit which progresses the game by invoking the various event processes;
a real map storage unit which stores real map information containing geographical information in a real world;
a virtual map information generation unit which generates virtual map information including coordinate information of the objects on virtual geographical information corresponding to the geographical information on the real map information in accordance with a game progress by the game progress processing unit;
a positional information acquisition unit which selects a coordinate position in the real world;
a real display data generation unit which generates real display data indicating the coordinate position selected by the positional information acquisition unit on the real map information on the basis of the coordinate position;
a virtual display data generation unit which generates virtual display data showing the character on the virtual map information corresponding to the coordinate position acquired by the positional information acquisition unit on the basis of the coordinate position;
a moving path recording unit which calculates and records a moving path on the basis of a displacement history of the coordinate position selected by the positional information acquisition unit;
a trail display unit which displays, as trails, the moving path recorded by the moving path recording unit on the real map information or the virtual map information; and
a display control unit which displays both or selected one of the virtual display data generated by the virtual display data generation unit and the real display data generated by the real display data generation unit, or displays part of either one overlapping the other, together with the trail displayed by the trail display unit,
wherein the positional information acquisition unit acquires the current position of another user in the real world, and selects, as the coordinate position, the position in which an object to be a proxy of the user is arbitrarily set on the real map information or the virtual map information as a proxy object, and
wherein the game progress processing unit sets the position of the proxy object in the map information on the basis of the position of the another user, and automatically moves the proxy object in accordance with the progress of the game.

US Pat. No. 10,188,944

FACILITATING USERS TO COMPLETE ACTIVE GAME ACTIONS

Kabam, Inc., San Francis...

1. A game server for providing offers to facilitate users to complete game actions within an online game, the game server comprising:one or more physical processors configured by machine-readable instructions to:
execute an instance of a game space in which the online game is played, and enable interaction of the users with the game space and/or each other by executing game actions on behalf of the users, wherein the game actions including game actions that require wait periods for completion; and
generate offers to remove and/or reduce the required wait periods of the game actions in exchange for consideration from the users, wherein the offers generated for the first user include:
a first offer to remove and/or reduce a first pending wait period required for completion of a first game action in exchange for a first amount of consideration;
a second offer to remove and/or reduce a second pending wait period required for completion of a second game action in exchange for a second amount of consideration; and
a third offer to remove and/or reduce both of the first pending wait period and the second pending wait period in exchange for a third amount of consideration.

US Pat. No. 10,188,943

COMMENTARY SYSTEMS AND METHODS

MLB Advanced Media, L.P.,...

1. A method of processing sports data in a computer network, the method comprising:storing, in a memory device, a plurality of predefined rules for generating game commentary data, each predefined rule including a predefined criterion and a corresponding predefined output, the predefined criterion identifying conditions to generate the corresponding predefined output;
receiving, by one or more servers comprising one or more hardware processors, via the computer network, raw game data relating to a current sporting event that is currently occurring, wherein the raw game data includes data captured at the current sporting event using one or more cameras;
determining, by the one or more servers, whether to provide the game commentary data based on (i) whether the raw game data satisfies at least one predefined criterion in the plurality of predefined rules, (ii) whether a previous play in the current sporting event produced any game commentary data, and (iii) whether any game commentary data was provided during a predetermined time period prior to the current time in the current sporting event;
generating, by the one or more servers, responsive to determining (i) the raw game data satisfying at least one predefined criterion in the plurality of predefined rules, (ii) the previous play in the current sporting event not producing any game commentary data, and (iii) no game commentary data being provided during the predetermined time period prior to the current time in the current sporting event, the game commentary data by applying the raw game data to the corresponding predefined output of the at least one predefined criterion, wherein the generated game commentary data comprises comments in the form of text related to action occurring during the current sporting event; and
providing, via the computer network, the generated game commentary data to an electronic user device for display.

US Pat. No. 10,188,925

BALL REBOUNDING SYSTEM

SPORTWORX, LLC, Imperial...

1. A rebounder for a ball, comprising:a frame comprising a perimeter support and an interior space within the perimeter support;
a first pair of tension rods arranged parallel to each other on opposite sides of the interior space, wherein each of the tension rods is movable within the interior space between a first position in which each tensions rod is spaced apart from the perimeter support within the interior space, and a second position in which each tension rod is spaced apart from the perimeter support within the interior space but closer to the perimeter support than in the first position;
an inelastic net comprising a plurality of cells, wherein the net is disposed within the interior space of the frame, and wherein rows of the cells proximate to a boundary of the net are connected to the tension rods, and wherein the rows of the cells are directly laced onto the tension rods; and
a plurality of inelastic fasteners connecting the tension rods to the frame when the tension rods are in the second position;
wherein the net is in a slackened state when the tension rods are in the first position, and wherein the net is in a taut state when the tension rods are in the second position; and
wherein the perimeter support of the frame is straight when the tension rods are in the first position, and wherein the perimeter support is bowed inwardly toward at least one of the tension rods when the tension rods are in the second position.

US Pat. No. 10,188,923

ATHLETIC TRAINING TOOL

BODY ARTS GYM, LLC, Phil...

1. An athletic training device for training a user to maintain proper swinging position, the device comprising:a mouth piece having symmetric top part and bottom part configured in a spring loaded clam-shell-like clip arrangement;
wherein said top part and bottom part each include:
a grasp portion,
a bite guard portion, and
a clip opening portion;
wherein the top and bottom grasp portions are separated by a spring that provides a preloaded closing force on the top and bottom opening portions in order to attach the mouth piece onto he collar or breast portion of a user's shirt;
wherein the top and bottom bite guard portions are each shaped to allow the user to bite while swinging athletic equipment and maintain proper head position; and
wherein the grasp portion is configured to allow the user to easily open and close the opening portions using their fingers or mouth.

US Pat. No. 10,188,904

SWITCHABLE INTELLIGENT FITNESS HANDLE AND INTELLIGENT FITNESS SET INCLUDING THE SAME

EGGPLANT TECHNOLOGIES, G...

1. A switchable intelligent fitness handle, wherein a processor, a movement posture sensor and a touch sensor are built in the handle;the movement posture sensor and the touch sensor are connected respectively to the processor;
one end of the handle is closed; a bayonet is arranged at the other end of the handle;
the bayonet is switchable and hot-pluggable, configured to connect respectively to a plurality of handheld fitness equipments;
a pin connector matched with the bayonet is arranged in each of the plurality of handheld fitness equipments;
when the handle is connected to one of the plurality of handheld fitness equipments, the processor receives an equipment identification number transmitted by the handheld fitness equipment through the pin connector, collects movement information of the corresponding handheld fitness equipment based on the received equipment identification number, and uploads the movement information to a mobile terminal or a cloud server.

US Pat. No. 10,188,886

VALVE MONITORING

Amtron Valve Monitoring D...

1. A valve gear box having a valve monitoring function, said valve gear box being for mounting to a valve that has a fluid passageway and a gate therefor, said gear box providing a gear driven link for moving said gate between open and closed conditions of said fluid passageway, said valve gear box being in a housing that has a mounting for permitting operative connection to the valve via a mounting flange of said valve,said mounting and said mounting flange having a valve monitoring sensor operatively positioned therewith, said sensor being settable in one state when said mounting and said mounting flange are in assembled relationship to each other but being configured to change from said one state if there is a separation of the fastened connection of the mounting and said mounting flange, whereby a change in state from said one state can be used to monitor a separation of the assembled relationship of said mounting and said mounting flange and trigger an alarm condition,
wherein said gear driven link has a gate position sensor associated therewith so that said gate position sensor can be in one state when the gate is in an opened condition, and which can change from said one state when said gate is moved towards a closed condition,
whereby a change of state from said one state can be used to monitor a closing of said gate and trigger an alarm condition.

US Pat. No. 10,188,882

COMPONENT FOR FITTING TO A SAFETY HARNESS

Marco Einhaus, Wessling ...

1. A component for being attachable to a safety harness for a human user for at least partially keeping free the femoral vein of the user, the component comprising:a carrier structure;
two leg harness pads attached to the carrier structure with such a distance to each other, that a leg harness pad-free portion of the carrier structure, which remains between the leg harness pads is configured to keep a femoral vein of the user at least partially free, in a state of the component attached to the safety harness, when the user has put on the safety harness; and
a detachable fixing mechanism which is attached or attachable to the carrier structure, for detachably fixing the component to the safety harness,
wherein the leg harness pads are formed wedge-shaped, such that respective front faces of the wedge-shaped leg harness pads are facing each other with the leg harness pad-free portion in between.

US Pat. No. 10,188,880

FILTER ASSEMBLY FOR A BREATHING APPARATUS

Cleanspace IP Pty Ltd, A...

1. A filter assembly for a breathing apparatus, the filter assembly comprising:a frame defining an aperture dimensioned to receive and retain a filter element;
a cover connected to the frame and dimensioned to cover the aperture;
a filter element; and
an indicator for indicating when the filter element is retained in the filter frame and the cover is arranged across the aperture, the indicator including a tab extending from each of the filter frame and the filter element;
wherein one of the tabs is arranged to overlay and substantially cover the other tab when the filter element is retained in the filter frame.

US Pat. No. 10,188,850

FLUID LEVEL MONITORING DEVICE

FIVAMED INC., Halifax (C...

1. A method for monitoring and/or controlling delivery of a fluid to a patient through a flexible fluid delivery tube, the method comprising:providing a fluid-flow monitoring and/or control device removeably mountable to a fluid delivery system configured to deliver the fluid to the patient, the fluid delivery system including the flexible fluid delivery tube, the fluid-flow control device including a fluid level sensing mechanism;
using the fluid level sensing mechanism to detect that a fluid level of the fluid supplied through the flexible delivery tube has dropped below a predetermined level; and
in response to the detection of the fluid level dropping below the predetermined level:
generating an alarm indicating that the fluid level has dropped below the predetermined level; and
reconfiguring a flow control mechanism from a first configuration in which flow of the fluid through the fluid delivery system is not blocked to a second configuration in which the flow of the fluid through the fluid delivery system is blocked by a portion of the flow control mechanism that is moved to interface with the fluid delivery system by:
configuring a trigger that is operatively coupled with the flow control mechanism in an actuated configuration in which the flow control mechanism is in the first configuration;
engaging a latching mechanism with a trigger to retain the trigger in the actuated configuration prior to the detection of the fluid level dropping below the predetermined level; and
inducing a length change in a shape memory wire that is operatively coupled with the latching mechanism so as to disengage the latching mechanism from the trigger and move the trigger from the actuated configuration to a non-actuated configuration which reconfigures the flow control mechanism from the first configuration to the second configuration in response to the detection of the fluid level dropping below the predetermined level.

US Pat. No. 10,188,844

ACCESS PORT LOCATOR

Primo Medical Group, Inc....

1. A medical device comprising:an access port locater configured to locate a subcutaneous access port located beneath a skin surface of a host, the access port locator including
at least one annular ring forming an aperture, the at least one annular ring having a longitudinal ring length disposed between first and second opposing ends and a longitudinal axis extending along the longitudinal ring length, the at least one annular ring positionable on the skin surface of the host with the first end of the at least one annular ring in contact with the skin surface and the longitudinal axis of the at least one annular ring substantially perpendicular to the skin surface;
at least one stabilizing flange configured to stabilize the access port locater on the skin surface, the at least one stabilizing flange extending laterally from the longitudinal ring length of the at least one annular ring;
at least one needle guard configured to shield a hand of a user of the access port locator when the hand is positioned on the stabilizing flange;
a first end region at the first end of the at least one annular ring forms an annular protrusion relative to the at least one stabilizing flange which is arranged to provide a pressure concentration ridge to press into the skin surface; and
the annular protrusion disposed adjacent the aperture.

US Pat. No. 10,188,843

ULTRASOUND AND MICROBUBBLES IN OCULAR DIAGNOSTICS AND THERAPIES

UNIVERSITY OF SOUTHERN CA...

1. A method of treating a retinal blood vessel blockage of a patient, the method comprising:applying first ultrasound energy generated by an ultrasound probe to locate an area of blockage within a retinal blood vessel;
directing gas-filled microbubbles to the area of blockage within the retinal blood vessel, wherein the microbubbles are not loaded with a therapeutic agent; and
breaking up clots that are causing blockage at said area of blockage by delivering second ultrasound energy generated by the ultrasound probe to the area of blockage, wherein the delivering causes the microbubbles to activate or rupture.

US Pat. No. 10,188,839

SYSTEMS AND METHOD FOR BYPASSING AN ANASTOMOSIS SITE

Colospan Ltd., Kfar-Saba...

1. An apparatus for delivery of a device into a hollow organ comprising:(a) an elongated tube having proximal and distal openings and being configured for carrying the device on a distal portion thereof; and
(b) a tubular net structure for covering said distal portion of said elongated tube, said tubular net structure being at least partially covered by, and separate from, an elastic constraining tube, said tubular net structure and said elastic constraining tube being retrievable into said elongated tube through said distal opening such that when the device is mounted on said distal portion and covered by said tubular net structure and said tubular net structure is partially covered and constrained by said elastic constraining tube, retrieval of said tubular net structure and said elastic constraining tube into said elongated tube uncovers the device for delivery into the hollow organ, wherein said tubular net structure is configured for reducing friction between said elastic constraining tube and the device thereby facilitating uncovering of the device.

US Pat. No. 10,188,834

ADJUSTABLE BENT SHEATH TUBE

Lifetech Scientific (Shen...

1. An adjustable bend sheath tube, comprising a tube body having a distal end and a proximal end, a traction mechanism and a fixing and connecting mechanism; the traction mechanism comprising an anchor ring and a traction wire: the anchor ring being coaxially embedded in a distal elastic segment of the tube body; the traction wire being arranged in a side wall of the tube body, and extending along the axial direction of the tube body; the traction wire comprising a first segment and a second segment which are axially parallel with each other, the first and second segments having a distal end that are connected to each other by a bending portion, with the first segment connected to the fixing and connecting mechanism near the proximal end of the tube body, and with the bending portion extending around the anchor ring to hook the anchor ring, wherein the tube body is provided with first and second independent traction wire channels which are parallel to each other and extend along the axial direction of the tube body, each traction wire channel having a lumen defined by a luminal wall, with the first segment of the traction wire extending inside the first traction wire channel and the second segment of the traction wire extending inside the second traction wire channel, wherein the first and second segments are separated by the luminal walls of the first and second traction wire channels;wherein the first and second traction wire channels are positioned side-by-side from the proximal end of the tube body to the distal end of the tube body along a same side of the tube body.

US Pat. No. 10,188,831

SYSTEMS AND METHODS FOR CATHETER TIP PLACEMENT USING ECG

AngioDynamics, Inc., Lat...

1. A method comprising the steps of:acquiring a plurality of surface ECG signals from at least one surface ECG electrode and a plurality of intravascular ECG signals from an intravascular ECG electrode, the intravascular ECG electrode configured to be coaxially surrounded by a peripherally inserted catheter, the at least one surface ECG electrode and the intravascular ECG electrode configured to be connected to a central processing unit (CPU);
generating an averaged surface ECG signal from the plurality of surface ECG signals and an averaged intravascular ECG signal from the plurality of intravascular ECG signals;
determining a first fiducial point by identifying a first extremum within the averaged surface ECG signal;
establishing a first ECG search window between a first predetermined value and a second predetermined value, both the first predetermined value and the second predetermined value being offset from the first fiducial point;
determining a second fiducial point by identifying a second extremum within the first ECG search window;
establishing a second ECG search window by identifying a first local extremum on a first side of the second fiducial point and a second local extremum on a second side of the second fiducial point;
applying the second ECG search window to the averaged intravascular ECG signal to generate an intravascular ECG search window;
moving the intravascular ECG electrode from a first location to a second location; and
displaying on a display in communication with the CPU, a graphical instruction to a user to advance or retract the intravascular ECG electrode, the graphical instruction to the user to advance or retract the intravascular ECG electrode is in response to the user moving the intravascular ECG electrode from the first location to the second location.

US Pat. No. 10,188,823

CONTINUOUS HIGH PRESSURE DELIVERY SYSTEM

Philip Morris USA Inc., ...

1. A drug delivery system, comprising:an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, the capillary passage having a capillary passage inlet and a capillary passage outlet, (ii) a first heater body operable to heat the capillary passage to a temperature range effective to at least partially volatilize the liquid formulation in the capillary passage, the capillary passage being fitted within the first heater body, (iii) a second heater body arranged to be remote to the capillary passage and the first heater body, and (iv) at least one gas passage arranged such that gas is heated by the second heater body to produce a heated gas, the at least one gas passage having a gas passage inlet and a gas passage outlet, and wherein the at least one gas passage is separated from the capillary passage and the first heater body;
a pumping unit adapted to supply the liquid formulation to the aerosol generator unit;
an aerosol confinement member arranged at a distal end of the first heater body and configured to capture aerosols produced by the capillary passage;
a flow passage having an inlet end in fluid communication with an outlet of the aerosol confinement member and an outlet end adapted for connection to a patient interface which supplies ventilation to a patient's lungs; and
the aerosol confinement member connecting the capillary passage outlet and the gas passage outlet, wherein the capillary passage outlet is configured to inject the aerosols produced by the capillary passage into the aerosol confinement member and the gas passage outlet is configured to inject the gas heated by the second heater body into the aerosol confinement member, and wherein the aerosol confinement member is arranged to mix the aerosols produced by the capillary passage with the heated gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and operable to direct the mixed aerosol into the inlet end of the flow passage.

US Pat. No. 10,188,818

RESPIRATORY MASK

Intersurgical AG, Vaduz ...

1. A respiratory mask for delivering inspiratory gas to a wearer, the mask comprising a mask body shaped to define a cavity adapted to fit about the mouth and nose of the patient, wherein the mask body comprises a nose cavity portion and a mouth cavity portion, the mask body being shaped such that the maximum depth of the cavity defined by the nose portion is greater than the depth of the cavity defined by the mouth portion, the nose cavity portion comprising an inspiratory gas inlet port and the mouth cavity portion comprising an expiratory gas monitoring port, at a location spaced from the inlet port, wherein the gas monitoring port is an inlet of a port connector formation depending from the mask body, and wherein said port connector formation is integral with the mask body.

US Pat. No. 10,188,807

LOW RESIDUAL VOLUME SYRINGE/CONDUIT COMBINATION AND SYRINGE FOR SUCH A SYRINGE/CONDUIT COMBINATION

Linesbridge Pharma Group ...

1. A syringe/conduit combination comprising a syringe part and a conduit part connectable or connected to the syringe part;wherein one of said parts has a frustoconical male slip fitting and the other one of said parts has a female slip fitting having a frustoconical internal surface extending up to an internal end;
wherein said male slip fitting is inserted or insertable into said female slip fitting establishing a press fitted connection with the male slip fitting axially extending up to an axial distance of less than 0.1 mm from the internal end of the female slip fitting;
wherein a first liquid discharge channel extending through said male slip fitting and a second liquid discharge channel extending through said female slip fitting are in mutual serial communication for liquid transfer when said connection between said male and female fittings is established;
wherein the syringe part comprises a hollow barrel and a plunger inserted into the hollow barrel from a proximal end, axially displaceable in the hollow barrel and sealingly fitting against an internal wall of the hollow barrel;
wherein the plunger and the hollow barrel have abutments limiting axial displacement of the plunger in a distal direction to a maximally inserted position; and
wherein, when the male slip fitting is axially inserted into the female slip fitting, a distal end of the plunger when in its maximally inserted position is at an axial distance from an opposite one of the slip fittings that is equal to or less than the axial distance between the male slip fitting and the internal end of the female slip fitting.

US Pat. No. 10,188,797

PHARMACEUTICAL INJECTION DEVICE

PHC HOLDINGS CORPORATION,...

1. A pharmaceutical injection device, comprising:a main body case having a first end side, the first end side having an injection needle mounting portion and an injection needle mounted to the injection needle mounting portion;
a pharmaceutical syringe mounting portion that is provided inside the main body case and to which a pharmaceutical syringe is mounted;
a piston that is provided movably with respect to the pharmaceutical syringe;
a drive mechanism configured to drive the piston;
a cover that covers the injection needle mounting portion in an opened or closed state wherein, in the opened state of the cover, the injection needle mounting portion is exposed to an outside while the cover is still attached to the first end side of the main body case;
a stepped part that is formed on a rear side of the injection needle in a piercing direction; and
an opening and closing mechanism for the cover, provided on the first end side of the main body case,
wherein, in the opened state of the cover, a distal end face of the stepped part on an injection needle side is positioned at substantially a same height as a front of the cover, and a surface of the cover is a face that is configured to come into contact with a skin of a patient at an outer peripheral position of the injection needle mounting portion,
wherein, in the closed state of the cover, the injection needle mounting portion is not exposed to the outside while the cover is still attached to the first end side of the main body case, and
wherein the opening and closing mechanism includes:
a first slide pin provided near the cover on an injection needle mounting portion side of the cover;
a first slide groove configured to guide a sliding of the first slide pin in an outer peripheral direction of the injection needle mounting portion;
a first slide spring configured to bias the first slide pin in a closing direction of the cover;
a second slide pin provided on an outer peripheral side of the injection needle mounting portion;
a second slide groove configured to guide a sliding of the second slide pin in the outer peripheral direction of the injection needle mounting portion; and
a second slide spring that is in communication with the second slide pin and is configured to bias in the closing direction of the cover.

US Pat. No. 10,188,786

METHOD AND SYSTEM FOR TREATING BLADDER CONDITIONS

Elmedical Ltd., Hod-HaSh...

1. A method of treating an overactive bladder or interstitial cystitis comprising:(a) delivering a first volume of a fluid maintained at a temperature of 40-48° C. directly into a urinary bladder of a subject having the overactive bladder or interstitial cystitis and circulating said volume of fluid within the urinary bladder;
(b) gradually delivering a second volume of said fluid maintained at a temperature of 40-48° C. into said urinary bladder up to a predetermined fluid volume and/or pressure based on a tolerance of said subject to thereby relax detrusor muscles and stretch the urinary bladder; and
(c) evacuating said fluid and urine from said urinary bladder.

US Pat. No. 10,188,778

ARTIFICIAL HEART

Stephen K. Shu, Irvine, ...

1. An artificial heart, comprising:an outer housing comprising a right heart valve plate and a left heart valve plate spaced axially apart by a first bellows spring and a second bellows spring;
a solenoid connected to a first drive coil and a second drive coil, the first drive coil operably connected to the right heart valve plate and the second drive coil operably connected to the left heart valve plate;
a magnet operably connected to a plate structure spaced axially between the first drive coil and the second drive coil, the magnet operably connected to a first end of the first bellows spring and a first end of the second bellows spring, the magnet configured to move axially upon activation of the first drive coil and the second drive coil resulting in conversion of electrical energy to mechanical energy, thereby axially elongating one of the first bellows spring and the second bellows spring and simultaneously contracting the other of the first bellows spring and the second bellows spring resulting in the release of energy, moving blood in or out of the artificial heart by movement of the plate structure;
at least one sensor configured to determine at least one of the position, velocity, and direction of travel of the magnet; and
a servomechanism controller configured to receive data from the sensor and control power to the first drive coil and the second drive coil, thereby actuating the magnet and the plate structure.

US Pat. No. 10,188,777

LIPOSUCTION DEVICE AND SYSTEM AND USE THEREOF

Aurastem LLC, Solana Bea...

1. A device that allows for the removal of adipose tissue with a needle(s), comprising a needle hub that comprises at least one needle having a needle barrel that contains between 1-1000 holes around the circumference of the needle barrel which allows passage of adipose tissue and other lipoaspirate and a guide that prevents the over insertion and under insertion of the needle and thus allows collection of subcutaneous adipose tissue at desired depth,wherein the guide is curved to allow the needle to puncture skin and the needle is adapted to remain in the subcutaneous layer of adipose tissue.

US Pat. No. 10,188,765

SUPER DRY FOG GENERATOR

HUBEI HOPE PHARMACEUTICAL...

1. A super dry fog generator comprising a liquid-storage device, an atomization device, an air-blower and a dry separation device; wherein the dry separation device comprises a top and a bottom, and an opening on the top; wherein the dry separation device is above the liquid-storage device and connected with the liquid-storage device; wherein the atomization device is located at an exterior of the liquid-storage device and comprises two ends; wherein the two ends of the atomization device are connected with the air-blower and an interior of the dry separation device, respectively; wherein the atomization device is connected with the liquid-storage device, and a liquid entering into an interior of the atomization device is blown into the interior of the dry separation device by the air-blower, wherein the dry separation device comprises at least two connected cavity structures; and wherein the bottom of the dry separation device is joined to a top of the liquid-storage device and connected with an interior of the liquid-storage device.

US Pat. No. 10,188,764

APPARATUS FOR DISINFECTING AN ENCLOSED SPACE

Nevoa Life Sciences, Sco...

1. An apparatus for disinfecting an area or enclosed space, the apparatus comprising:a device for producing a fog comprising liquid droplets having diameters between about 0.5 micron and about 20 microns;
at least one port for discharging the fog into the area or enclosed space;
an in-line dehumidifying device; and
a low-moisture droplet mesh screen upstream of the dehumidifying device.

US Pat. No. 10,188,745

BINDING PROTEIN DRUG CONJUGATES COMPRISING ANTHRACYCLINE DERIVATIVES

NBE-THERAPEUTICS AG, Bas...

1. A binding protein-drug conjugate (BPDC) comprising an anthracycline (PNU) derivative, the BPDC having the following formula:
wherein
a) each of L1-L3 represents a linker, wherein L1 is optional and both L2 and L3 are mandatory,
b) L1, when present, represents an alkylene-amino linker or an alkylene-diamino linker,
c) L2 represents an oligo-glycine peptide,
d) L3 represents a peptide motif that results from specific cleavage of a sortase enzyme recognition motif,
e) X and Y each represent one or more optional linkers,
f) BP is a binding protein, and
g) n is an integer ?1 and ?10.

US Pat. No. 10,188,677

IRON SUPPLEMENT COMPOSITION

THE D DROPS COMPANY INC.,...

1. A composition consisting of:a non-encapsulated iron salt; and
a carrier of a digestible edible oil that is a liquid at 20° C.

US Pat. No. 10,188,658

THERAPEUTIC USE OF DIAMINOPHENOTHIAZINES

WisTa Laboratories Ltd., ...

1. A method of treating a cognitive or CNS disorder in a patient, comprising orally administering to said patient a delayed-release formulation of a dosage unit containinga 3,7-diaminophenothiazine (DAPTZ) compound in stable crystalline reduced form as active ingredient, selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof:
wherein:each of R1 and R9 is independently selected from: —H;
each of R3NA and R3NB is independently selected from: —H, C2-4alkenyl, and halogenated C1-4alkyl;
each of R7NA and R7NB is independently selected from: —H, C2-4alkenyl, and halogenated C1-4alkyl;
each of HX1 and HX2 is independently a protic acid, wherein X1 is an element or compound forming the conjugate base of the protic acid HX1, and X2 is an element or compound forming the conjugate base of the protic acid HX2; and
wherein if any of HX1 and HX2 are hydrohalic acids, then each are independently selected from HCl or HBr,wherein the delayed-release formulation releases less than 50% of the compound in 6 hours.

US Pat. No. 10,188,626

STABILIZED CABAZITAXEL FORMULATIONS

Cipla Limited, Mumbai (I...

1. A pharmaceutical composition, comprising a compound having the formula:or a pharmaceutically acceptable salt thereof and at least one solubilizer comprising a caprylocaproyl polyoxylglyceride, wherein the composition is injectable, further comprising albumin.

US Pat. No. 10,188,610

PROLONGED-RELEASE DIPHENIDOL COMPOSITION

INVEKRA, S.A.P.I. DE C.V....

1. A sustained release diphenidol single layer tablet, consisting of: a) from 15 to 50% diphenidol hydrochloride; b) from 0.1 to 20% of one or more binding agents; c) from 5 to 90% of one or more diluent agents; d) from 5 to 50% of one or more release modification agents; e) from 0.25 to 10% of one or more lubricating agents; and f) 0.1 to 10% of one or more gliding agents, wherein all of the ingredients of the tablet are mixed together prior to tabletting.

US Pat. No. 10,188,575

CERVICAL ORTHOTIC DEVICE

Core Products Internation...

1. A cervical orthotic device comprising:a base having a length and a width;
sidewalls extending upwardly from the base, wherein the sidewalls include:
opposingly paired lateral sidewalls; and
opposingly paired longitudinal sidewalls:
a cervical support surface opposite said base and uniting said sidewalls, the cervical support surface having a cervical engagement ridge extending parallel with, and in the same direction as, the width of the base, the cervical support surface also including:
a first planar portion adjacent a first longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom;
a second planar portion adjacent a second longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom; and
an arcuate portion intermediate the first planar portion and the second planar portion and extending from a first lateral sidewall of the opposingly paired lateral sidewalls to the other lateral sidewall of the opposingly paired lateral sidewalls, the arcuate portion delimiting the cervical engagement ridge for the cervical support surface;
wherein an apex of the cervical engagement ridge defines a height of the cervical orthotic device from the base;
wherein a ratio of a maximum height of the cervical orthotic device to the length is greater than or equal to 1.1575; and
wherein a height of the first longitudinal sidewall of the opposingly paired longitudinal sidewalls is about 1.5 times a height of the second longitudinal sidewall of the opposingly paired longitudinal sidewalls.

US Pat. No. 10,188,570

METHOD OF REDUCING SURGEON FATIGUE DURING AN OPERATION WHILE REDUCING COLLECTION OF FLUIDS FROM THE OPERATION ON THE FLOOR OF THE OPERATING ROOM BY ABSORBING FLUIDS LEAKING ONTO THE FLOOR OF THE OPERATING ROOM AND APPARATUS THEREFOR

XODUS MEDICAL, INC., , PA...

1. An absorbent, anti-fatigue operating room mat comprising:a support layer to be disposed on the floor of an operating room during performance of an operating room procedure;
a fluid-resistant layer being disposed on top of said support layer during performance of an operating room procedure;
a fluid-absorbent layer being disposed on top of said fluid-resistant layer during performance of an operating room procedure;
a shock-absorbing layer being disposed on top of said fluid-absorbent layer during performance of an operating room procedure;
said shock-absorbing layer comprising shock-absorbing foam material to absorb shocks and reduce fatigue on operating room personnel standing on said anti-fatigue operating room mat;
said shock-absorbing layer comprising holes to permit passage of operating room fluids, generated during performance of an operating room procedure, through said shock-absorbing layer and to said fluid-absorbent layer;
said fluid-absorbent layer comprising a fluid-absorbent material to absorb, capture, contain, and retain operating room fluids that pass through said holes in said shock-absorbing layer to thereby minimize deposition of the operating room fluids on the floor of an operating room;
said fluid-resistant layer comprising a fluid-resistant material to resist the passage of operating room fluids, not absorbed by said fluid-absorbent layer, through and out of said anti-fatigue operating room mat; and
said support layer comprising an anti-skid material to minimize or prevent unwanted sliding or skidding of the anti-fatigue operating room mat on the floor of an operating room during performance of an operating room procedure.

US Pat. No. 10,188,566

LIFTING MECHANISM

ACCORA LIMITED, (GB)

1. A lifting assembly comprising:a telescopic post assembly including a first tubular member, a second tubular member slidingly engaged with the first tubular member, and a third tubular member slidingly engaged with the second tubular member, the first, second and third tubular members being coaxial;
an actuator configured to move the second tubular member axially with respect to the first tubular member; and
a pulley mechanism comprising:
a first wheel rotatably mounted at a first end of the second tubular member;
a second wheel rotatably mounted at a second end of the second tubular member;
a first length of cable having a first end fixed to the first tubular member and a second end fixed to the third tubular member, the first length of cable being engaged with the first wheel; and
a second length of cable having a first end fixed to the first tubular member and a second end fixed to the third tubular member, the second length of cable being engaged with the second wheel,
wherein the pulley mechanism is arranged such that the movement of the third tubular member relative to the first tubular member is at a greater speed than the movement of the second tubular member relative to the first tubular member.

US Pat. No. 10,188,554

WOUND DRESSING

IWMT Intellectual Propert...

1. A wound dressing, for absorbing exudate from a wound on which the wound dressing is placed, comprising:a porous, highly absorptive fiber dressing made up of two or more different types of absorbent material comprising a first absorbent material in the form of a non-woven fabric and a second absorbent material in the form of a woven mesh fabric; and
a negative surface charge on a surface of the dressing, wherein the negative surface charge is created though friction, and further wherein the negative surface charge on the wound dressing attracts positive ions from the wound exudate to form an electric double layer that attracts negative charged particles comprising bacteria and cytokines to the surface of the dressing.

US Pat. No. 10,188,545

FLEXIBLE CONE-SHAPED INTRA-VAGINAL SUPPORT DEVICE

WATKINS-CONTI PRODUCTS, I...

11. A vaginal insert device for use in improving symptoms associated with pelvic organ prolapse, urinary incontinence, or both pelvic organ prolapse and urinary incontinence, comprising:an upper portion, which is made of an elastic and non-absorbent material, having a cone-shaped body, having a circular transverse cross-section throughout a length of the upper portion, having a wall with an interior side and an exterior side, an upper open end, a lower end, and a hollow interior, wherein a circumference of the upper portion decreases from the upper open end to the lower end, wherein the upper open end of the upper portion is the innermost portion of the vaginal insert device during insertion, and wherein the wall of the upper portion is configured to be squeezed to make the upper portion into a more compact shape for easier insertion of the vaginal insert device, and wherein said wall expands hack to its original shape alter the insertion;
an exterior rim surrounding and protruding from the exterior side of the wall of the upper portion, the exterior rim being adjacent to said upper open end;
a plurality of ridges surrounding and protruding from the exterior side of the wall of the upper portion, the plurality of ridges being spaced apart from the upper open end to the lower end, wherein the plurality of ridges are distributed along an entire length of the upper portion from the lower end to the exterior rim;
wherein said upper portion, with said exterior rim and said plurality of ridges, hold the vaginal insert device securely in place to impose pressure on the urethral sphincter, or to support pelvic organs, or to both impose pressure on the urethral sphincter and support pelvic organs, when the device is inserted; and
a stem extending from said lower end of said upper portion, wherein the upper portion and the stem comprise an integral one-piece device made from said elastic and non-absorbent material, wherein the stem is configured to be accessed from the exterior of a vagina when the vaginal insert device is inserted in said vagina, and wherein said stem assists in removal of the vaginal insert device.

US Pat. No. 10,188,544

PENILE IMPLANT

POWELL DEVELOPMENT GROUP,...

1. A penile implement comprising:a top film;
a bottom film adhered to the top film such that a reservoir exists between the top film and bottom film, wherein each of the top film and bottom film are distinct films that are welded, or glued to one another;
an adhesive layer formed on the bottom film;
a bottom release layer covering at least a portion of the adhesive layer; and
wherein a hole is formed in the bottom film, whereby during use, a user may remove the bottom release layer and adhere the bottom film with a user's penis such that bodily fluids secreted from the user's penis pass through the hole and into the reservoir formed between the top film and bottom film.

US Pat. No. 10,188,543

FOLDING MENSTRUAL CUP

Guangzhou Tianyuan Silico...

1. A folding menstrual cup comprising:an outer cup body with a top and a bottom, wherein a top accommodating cavity is formed inside the outer cup body and a round opening is provided at the top of the outer cup body; at a side opposite to the opening, the bottom of the outer cup body is connected to a flow guiding pipe via a folding part;
the flow guiding pipe with a pipe orifice in communication with the top accommodating cavity of the outer cup body, where a valve controlling communication to the pipe orifice is arranged on the flow guiding pipe; and
the folding part being capable of protruding upward and enabling the top end of the flow guiding pipe to extend into the top accommodating cavity of the outer cup body along with the folding part; wherein the folding part is capable of straightening downward and a bottom accommodating cavity is formed inside the folding part.

US Pat. No. 10,188,542

COMPLETE FLOW DIVERSION INTESTINAL OSTOMY SURGERY KIT

Jianjiang Lin, Hangzhou ...

1. A flow diversion intestinal ostomy surgery kit, comprising:at least an ostomy tube, said ostomy tube comprising: a tube body; near the front end of the tube body a deformable balloon; said tube body forming a drainage section at a preceding part of the balloon; a fine tube is provided within a tube wall of said tube body or inside said tube body; a front end of the fine tube penetrates the tube wall of said tube body and is in communication with an inner cavity of the balloon; a rear end of the fine tube connects a connector for injecting fluid into the balloon with a one-way valve; said connector is equipped with a manometer for measuring pressure caused by the balloon impressed to the intestinal wall; said balloon and an intestinal wall form a sealed structure that blocks matters inside of an intestine after filled with fluid via said connector; there is a drainage port at the drainage section for guiding matters inside of the intestine out by said tube body;
wherein said flow diversion intestinal ostomy surgery kit further comprises a ring-shaped fixing plate; an exterior wall of the tube body is provided with a ring-shaped groove; said ostomy tube is fixedly connected to an abdominal wall of a patient via the ring-shaped fixing plate that matches the ring-shaped groove;
wherein an inner ring of said ring-shaped fixing plate is provided with four jaws configured to touch the ostomy tube body and extending along a diameter of said ring-shaped fixing plate, said jaws provided in pairs with an end of each jaw configured to be directly across the ostomy tube body from another jaw end, a space between ends of the four jaws is slightly smaller than an outer diameter of said tube body, said ring-shaped fixing plate stuck in said ring-shaped groove by way of pressing said jaws.

US Pat. No. 10,188,540

SACROILIAC BELT

BRACE FIT LLC, Owariasah...

1. A sacroiliac belt comprising a belt pair that forms a pelvic holding loop to hold a user's pelvis from a buttock side or a lumbar back side, entirely wrapping the pelvis, the belt pair comprising:a ring-shaped ilium belt (A) configured to be wound around the user's waist, surrounding the user's right and left ilia; and
a second belt selected from:
either a buttock belt (B1) configured to be wound around the user's waist passing under the user's buttocks, lifting up the buttocks; or
a lumbar belt (B2) configured to be wound around the user's waist passing the user's lumbar back, which is a back side of the user's lumbar curve located immediately above the pelvis, wherein:
the second belt is shorter than the ilium belt,
the sacroiliac belt comprises rings at both ends of the second belt,
while the ilium belt placed through the rings, the both ends of the second belt each connected to the ilium belt in a pair of connection areas placed inside both ends of the ilium belt through a reversible connection through which the both ends of the second belt are reversibly connected to the pair of connection areas on the ilium belt via touch fasteners that consist of first and second components, the first components attached in the connection areas on the ilium belt, the second components attached on the both ends of the second belt the first components have widths within which positions of connection between the first and second components are adjustable,
the second belt comprises:
a band-shaped main portion;
the rings, and
a pair of connection portions each comprising the second components of the touch fasteners, and connected to both ends of the main portion via the rings,the both ends of the main portion and the connection portions each attached to the rings in a movable manner along rims of the rings, andthe rings are placed more inside the both ends of the second belt than the second components are.

US Pat. No. 10,188,539

STABILIZING SYSTEM FOR A KNEE BRACE

SpringLoaded Technology I...

1. A knee brace for assisting the extension or flexing of a limb, comprisingsubstantially rigid upper and lower frames connected by a hinge,
the upper frame comprising hinge arms each having one end connected to the hinge and an opposite end connected to the other hinge arm by an upper leg bearing member for bearing against a user's leg above the knee,
the lower frame comprising first and second hinge arms extending in a first direction and each having one end connected to the hinge and an opposite end connected to the other hinge arm by a lower leg bearing member for bearing against the user's leg below the knee, a first strap support being provided on the first hinge arm and an opposing second strap support being provided on the second hinge arm,
at least one upper securing member for fixing the upper frame to the user's leg, and
a stabilizing strap for fixing the lower frame to the user's leg, the stabilizing strap comprising a substantially inelastic element for circumscribing the user's leg and a fixing element for securing the inelastic element in a set position, the inelastic element extending through the first and second strap supports, such that when the brace is in use the stabilizing strap is inhibited from moving relative to the lower frame in the first direction to support the lower frame on the user's leg and is slidable relative to the lower frame in a second direction that is orthogonal to the first direction, wherein when the knee brace is in use the stabilizing strap follows the user's leg motion in the second direction without shifting the lower frame relative to the user's leg in the first direction.

US Pat. No. 10,188,536

STENT-VALVE, DELIVERY APPARATUS, AND STENT-HOLDER THEREFOR

SYMETIS SA, Ecublens (CH...

1. A delivery device for delivering a stent-valve to an anatomical site for implantation, the delivery device comprising:a stent-holder; and
at least one projection extending radially away from an exterior surface of the stent-holder at a first distance, each projection being disposed within an individual recess formed in a body of the stent-holder wherein the body at least partially surrounds each projection;
wherein:
the at least one projection includes a trunk portion having a first thickness and a ramp portion having a second thickness,
wherein the trunk portion extends radially outward from the exterior surface,
the ramp portion comprises a web of material extending along and from the exterior surface up to or adjacent the first distance, and the ramp portion faces, or is provided on a side of the projection that faces, at least one of a proximal direction of the device and away from a distal end of the device, and
the ramp portion extends laterally from the trunk portion, and the second thickness is less than the first thickness.

US Pat. No. 10,188,532

BLOOD-FLOW TUBING

Vascular Flow Technologie...

1. An intravascular stent comprising:a tubular member having an internal surface and an external surface,
wherein the tubular member has an internal helical formation to induce spiral-flow therethrough, and wherein the internal helical formation is provided on a portion of the internal surface and the internal surface extends beyond said portion,
wherein the internal helical formation has a helix angle between 5 and 50 degrees relative to a longitudinal axis of the stent, and wherein the tubular member is selected from the group consisting of:
(a) a tubular mesh member;
(b) a tubular member formed from a wire; or
(c) a tubular member of a mesh material that is formed from expanded sheet.

US Pat. No. 10,188,531

PROSTHESIS SOCKET WITH A RIGID STRUCTURE ARRANGED BETWEEN AN INTERNAL DEFORMABLE LAYER AND AN EXTERNAL DEFORMABLE LAYER

POMMIER ORTHOPEDIE, Vill...

1. A socket to interface a lower limb which has undergone amputation and a modular element, to be fastened to the socket at a distal end the socket comprising:an internal deformable layer consisting of silicone rubber, designed to be in contact with the lower limb that has undergone amputation;
an external deformable layer consisting of silicone rubber; and
a rigid structure arranged between the internal deformable layer and the external deformable layer,
wherein the socket extends along a longitudinal direction from a proximal end to the distal end, said proximal end defining an outer opening of the socket through which the lower limb that has undergone amputation is received, and
wherein the rigid structure comprises at least two posts and a base, each post extending along the longitudinal direction of the socket from the base located at the distal portion to an end of the post such that a distance from the end of the post to the proximal end of the socket is less than half a length of the post along said longitudinal direction, wherein ends of the at least two posts are not linked, so that the ends separate and approach each other due to an effect of a deformation of the internal layer and of the external layer, wherein the at least two posts and the base of the rigid structure are made together from a single monolithic rigid material, and
wherein, between two successive posts of the at least two posts, a first part of the external deformable layer is in contact with a first part of the internal deformable layer and wherein each of the at least two successive posts separates a second part of the external deformable layer from a second part of the internal deformable layer.

US Pat. No. 10,188,527

EXPANDABLE AND ADJUSTABLE LORDOSIS INTERBODY FUSION SYSTEM

SPINEEX, INC., Fremont, ...

1. A spinal implant device for placement between vertebral bodies, the device comprising:an expandable shell;
at least one wedge member;
at least one drive shaft; and
the expandable shell comprising a top member and a bottom member, at least the bottom member having tracking for receiving the at least one wedge member, the at least one drive shaft engaging with the at least one wedge member for moving the at least one wedge member along the tracking, the at least one wedge member engaging the top member and the bottom member, the at least one wedge member comprising a tapered configuration having an external helical thread, whereby the top member and bottom member move relative to each other in response to rotation of the at least one wedge member along the tracking to effect an expansion of the shell, the tracking comprising a cascading series of risers on interior surfaces of each of the top and bottom members, the cascading series of risers comprising individual riser members increasing in height along the interior surfaces and delivering corresponding staggered spaces in between the individual riser members so that the individual riser members and the corresponding spaces on the top member overlap the individual riser members and the corresponding spaces on the bottom member, permitting an interlocking engagement of the top and bottom members when the top and bottom members are in a contracted position, whereby the cascading series of risers on the interior surface of the top member intermesh with the cascading series of risers on the interior surface of the bottom member, and wherein the tracking is configured to increase a longitudinal position of the at least one wedge member along and relative to the interior surfaces of the top and bottom members within the shell as it travels along the tracking whereby the at least one wedge member engages the top and bottom members to selectively contact the shell.

US Pat. No. 10,188,524

ROTATIONAL DRIVE MECHANISM, TOOL AND METHODS FOR USING SAME

AESCULAP IMPLANT SYSTEMS,...

1. A spinal interbody device, comprising:a front surface;
a rear surface substantially opposed to the front surface;
an upper surface connected to the front surface and the rear surface;
a lower surface opposed to the upper surface and connected to each of the front surface and the rear surface;
at least one opening formed at the front surface, the at least one opening extending through the front surface;
at least one projection; and
a drive mechanism disposed adjacent the at least one opening and configured to move the at least one projection so that the at least one projection moves through at least one of the upper surface and the lower surface, the drive mechanism including a cam plate,
wherein the at least one opening formed at the front surface includes at least one first camming groove and the cam plate includes at least one second camming groove defined therein for retaining and guiding the at least one projection when the front surface is disposed adjacent to the cam plate, and at least one of the first camming groove and second camming groove is a spiral slot.

US Pat. No. 10,188,521

MULTIPLE-CAM, POSTERIOR-STABILIZED KNEE PROSTHESIS

MEDIDEA, LLC, Ann Arbor,...

1. A total knee replacement system comprising:a distal femoral knee-replacement component and a tibial component having a bearing surface and a tibial post with a posterior surface, wherein the distal femoral knee-replacement component comprises:
a body having a pair of medial and lateral condylar protrusions and an intercondylar region therebetween dimensioned to receive the tibial post, the body further having a cam mechanism bridging the intercondylar region, the cam mechanism having at least a first, second and third cam surface areas, with each of the first, second and third cam surface areas having a convex shape in a sagittal plane with different centers of radius;
the first convex cam surface area engaged with the posterior surface of the tibial post at approximately ninety degrees of flexion;
the second convex cam surface area being located anterior to the first cam surface area, when the knee is in extension and positioned posterior of the tibial post; and
the third convex cam surface area being located posterior to the first cam surface area, when the knee is in extension, and engaging the posterior surface of the tibial post after ninety degrees of flexion;
wherein none of the first, second and third cam surface areas engage the posterior surface of the tibial post when the knee is in extension; and
wherein the cam mechanism includes at least one concave cam surface area in the sagittal plane between at least two of the three convex cam surface areas.

US Pat. No. 10,188,517

INVERSION DELIVERY DEVICE AND METHOD FOR A PROSTHESIS

HLT, Inc., Maple Grove, ...

1. A method for inverting an invertible device comprising:advancing a first predetermined length of an invertible device distally from a delivery catheter, thereby establishing a target position;
limiting movement of said first predetermined length of said invertible device, thereby keeping said first predetermined length at said target position; and,
distally advancing a second predetermined length of said invertible device from said catheter so as to invert said second predetermined length into said first predetermined length.

US Pat. No. 10,188,504

WHIPSTITCHED GRAFT CONSTRUCT AND METHOD OF MAKING THE SAME

ARTHREX, INC., Naples, F...

1. A method of forming a graft, comprising:forming a stitched region in a tendon strand by threading a suture loop/needle construct through the tendon strand and advancing the suture loop/needle construct in a direction toward an end of the tendon strand, wherein the suture loop/needle construct includes a continuous suture loop attached to a needle.

US Pat. No. 10,188,498

EMBOLUS BLOOD CLOT FILTER DELIVERY SYSTEM

C. R. BARD, INC., Murray...

1. A blood filter delivery apparatus for delivery to a blood vessel having a vessel wall comprising:a) a catheter having a free end portion with a catheter opening and a catheter lumen that communicates with said catheter opening;
b) a filter and positioning assembly positioned within the catheter in a storage position wherein said assembly comprises an assembly member and a filter having a head and multiple filter leg members connected to the head;
c) a pusher that engages the assembly inside the catheter lumen, wherein the assembly member has an assembly member distal end adapted to engage one or more said filter leg members and a proximal end disposed within the catheter to define a stored position;
d) wherein the filter is positioned in between the catheter opening and the positioning assembly in said storage position; and
e) wherein the positioning assembly and filter are movable between said storage position within the catheter lumen and a preliminary dispensed position wherein said head is positioned distally of the filter legs and the catheter and at least some of the filter leg members are configured to engage the vessel wall while at least a portion of some of the filter leg members remain inside the catheter lumen.

US Pat. No. 10,188,497

IMPLANT CONVEYING DEVICE AND IMPLANTED MEDICAL INSTRUMENT

Lifetech Scientific (Shen...

1. An assembly, comprising:an implant for occluding a defect, the implant having a meshed body defining a through hole; and
an implant conveying device for delivering the implant to a treatment location, wherein the conveying device comprises a pusher, a control component, a connecting wire and a control wire;
the pusher, of which one end is connected to the control component, comprising a tube cavity and a lock hole communicated with the tube cavity;
one end of the control wire is connected to the control component, and the other end thereof is capable of being driven by the control component to be movably accommodated in the tube cavity of the pusher;
one end of the connecting wire is connected to the pusher or to the control component, and the other end thereof has a ring that extends through the through hole of the meshed body of the implant and then entering the lock hole; and
the control wire is capable of being driven by the control component to pass through the ring of the connecting wire to connect the implant with the conveying device, and the control wire is also capable of being driven by the control component to be disengaged from the ring of the connecting wire to release the implant so as to deliver the implant to the treatment location, wherein the conveying device is separated from the implant after the control wire is disengaged from the ring and the connecting wire is removed from the treatment location.

US Pat. No. 10,188,493

SURGICAL MESH WITH DIMENSIONALLY STABILIZED PORE

Atex Technologies, Inc., ...

1. A method of stabilizing a pore within a mesh fabric comprising the steps of:providing a mesh knit fabric made of a plurality of thermoplastic polymer yarns, the fabric having a first pore, the first pore having a first perimeter;
providing a frame comprising pins;
placing at least a portion of the fabric surrounding the first pore over the pins of the frame, whereby the portion of the fabric is temporarily held taut to define a taut fabric portion;
providing a support having an outer perimeter comprising a shape and having a tapered section;
inserting the support into the first pore so that the first pore perimeter is in contact with the outer perimeter of the support; and
placing the taut fabric portion and the support in an oven for a predetermined time at a predetermined temperature, whereby the first pore perimeter assumes the shape of the outer perimeter of the support.

US Pat. No. 10,188,489

SINUS IMPLANT

Star Generation Limited T...

1. A sinus implant, comprising:an implant body having a mounting hole axially defined there through;
a plurality of positioning threads that are provided in a periphery of the implant body, that extend spirally upwardly around the periphery of the implant body, and that have a width that gradually decreases in a direction from a bottom end of the implant body toward an opposing top end of the implant body;
a pushing portion that protrudes from a top end of the sinus implant, that has a diameter that is reduced compared to that of the implant body, and that comprises a flat end face having defined therein a recess space and that includes an outer guide edge that is a smoothly arched and extends around a border of the flat end face, and an inner guide edge that is a smoothly arched and extends around the recess space within the flat end face, wherein, the pushing portion has a periphery that is without the plurality of positioning threads; and
at least one spiral groove that extends around the periphery of the implant body across the plurality of positioning threads, that reaches the periphery of the pushing portion, and that intersects with and communicates with the recess space.

US Pat. No. 10,188,477

MOBILE MEDICAL CART

Neonatal Product Group, I...

1. A medical cart for transporting medical supplies, the cart comprising:a chassis having a plurality of wheels attached thereto;
a plurality of drawers supported on the chassis, wherein
at least one of the drawers is slidable along a first axis toward the chassis to a closed orientation and slidable away from the chassis along the first axis to an open configuration, and
at least one of the drawers has a drawer lock shiftable between a locked position in which it secures the drawer in the closed orientation and an unlocked position in which it allows the drawer to be in the open configuration;
a temperature-regulated compartment having
a storage space with a door,
a lock shiftable between a locked position in which it prevents the door from opening and an unlocked position in which it allows the door to open, and
a temperature-regulating unit that regulates a temperature of the storage space at a predetermined temperature;
a locking bar pivotally attached to the chassis and shiftable between a locked position in which it prevents opening of the drawers and the door of the temperature-regulated compartment and an unlocked position in which it allows the drawers to open when the drawer locks are in their unlocked positions and allows the door to open when the door lock is in its unlocked position so that the locking bar serves as a secondary safety lock for all the drawers and the door of the temperature-regulated compartment;
a headwall mount attached to the chassis having a vertically-adjustable bar and a horizontal cross bar;
a display attached to the chassis; and
a positionable task light attached to the chassis having a deformable body portion, and a light source.

US Pat. No. 10,188,474

SKIN-TO-SKIN CONTACT OBSTETRICAL SURGICAL DRAPE

CLEVER MEDICAL, Sanford,...

1. A surgical fenestration drape for the Cesarean delivery of a newborn, the drape comprising:a drape sheet having a surgical opening and a portal, said sheet having a sterile field side and an opposite non-sterile-field side;
a first means secured to a portion of the non-sterile field side of the drape, the first means being configured for closing the portal, said first means configured to be selectively manipulated from the non-sterile field side; and
a second means secured to a portion of the sterile field side of the drape, the second means being configured for closing the portal, said second means configured to be selectively manipulated from the sterile-field side;
whereby, the portal is configured for closing by the first means until birth, when said first means is configured to be withdrawn from the portal while a portion of the first means remains attached to the non-sterile field side of the drape sheet to provide a window for the newborn to be placed into skin-to-skin contact with the mother's chest, and thereafter the second means is configured to close the portal, the sterile field side and a portion of the first means configured to maintain the integrity of the sterile-field throughout ensuing procedure.

US Pat. No. 10,188,456

ELECTRODE ASSEMBLY FOR RF ENERGY ENABLED TISSUE DEBRIDEMENT DEVICE

Medtronic Xomed, Inc., J...

1. A blade assembly extending from a proximal region to a distal region, comprising:an outer shaft assembly including an outer shaft defining a lumen extending along a central axis, an outer circumference, a proximal end and a distal end opposite the proximal end, wherein the distal end defines a cutting window in the outer shaft assembly and a first electrode surface;
an inner shaft assembly rotatably disposed within the lumen of the outer shaft assembly about the central axis, the inner shaft assembly defining a distal portion, the distal portion further including a cutting tip;
an electrode body extending along the outer circumference and electrically isolated from the outer shaft, the electrode body defining a U-shape in cross section with respect to a plane that is perpendicular to the central axis and a second electrode surface spaced apart from the first electrode surface;
a hub rotatably supporting the outer shaft and the electrode body, wherein upon rotation of the hub about the central axis, the outer shaft and the electrode body rotate about the central axis;
a rotary electrical connection assembly comprising an outer connector and an inner connector rotatably disposed within the outer connector, the inner connector electrically connected to the electrode body;
an irrigation channel fluidly coupled with the hub and configured to deliver fluid from the proximal region to the distal region; and
wherein each of the outer connector, the inner connector and the electrode body are formed of a conductive material and extend a respective length in a direction parallel to the central axis, and further wherein, when viewed in cross section along an entirety of the respective length and with respect to the plane that is perpendicular to the central axis, each define a maximum distance from the central axis that includes conductive material such that, for a circle having an origin at the central axis and a circumference at the maximum distance, there exists at least one sector of the circle free of conductive material.

US Pat. No. 10,188,452

SINGLE ACTION TISSUE SEALER

COVIDIEN AG, (CH)

1. A bipolar forceps, comprising:a housing;
an elongated shaft extending from the housing;
an end effector coupled to a distal end of the elongated shaft, the end effector including a first jaw member and a second jaw member, at least one of the first and second jaw members movable relative to the other jaw member between an open position and a closed position;
a drive assembly disposed within the housing and selectively movable to actuate at least one of the first or second jaw members;
a cutting assembly disposed within the housing and selectively actuatable to advance a knife blade through at least one of the first or second jaw members; and
a handle assembly including:
a fixed handle extending from the housing and having a flexible latch detent and a detent rib each disposed within the fixed handle;
a movable handle pivotable relative to the fixed handle; and
a flange having a first end connected to the movable handle and a second end disposed within the fixed handle and adjacent the flexible latch detent, wherein a first movement of the movable handle causes the second end of the flange to engage the flexible latch detent indicating an end of a tissue sealing stage, and wherein continued movement of the movable handle causes the second end of the flange to engage the detent rib indicating an actuation of the cutting assembly.

US Pat. No. 10,188,451

VESSEL SEALER AND DIVIDER FOR USE WITH SMALL TROCARS AND CANNULAS

COVIDIEN AG, (CH)

1. An endoscopic bipolar forceps, comprising:an end effector assembly including a movable jaw member and a fixed jaw member , the movable jaw member movable relative to the fixed jaw member, the movable jaw member including a flange; and
a tubular reciprocating sleeve having a distal end defining a scoop-like support member, the scoop-like support member having an inner surface defining a channel that slidably receives a proximal end of the fixed jaw member, the inner surface of the scoop-like support member extending from a first lateral side of the fixed jaw member to a second lateral side of the fixed jaw member, the scoop-like support member defining an aperture therein at a distal end thereof configured to receive a portion of the flange of the movable jaw member, the scoop-like support member slidable in a proximal direction relative to the proximal end of the fixed jaw member to move the movable jaw member relative to the fixed jaw member from a first position, wherein the movable jaw member is disposed in spaced relation relative to the fixed jaw member, to a second position, wherein the movable jaw member is closer to the fixed jaw member,
wherein each of the movable and fixed jaw members is adapted to connect to a source of electrosurgical energy such that the movable and fixed jaw members are capable of conducting energy through tissue grasped therebetween.

US Pat. No. 10,188,442

CANNULATED BONE SCREW AND METHODS OF USE THEREFOF

CM DEVELOPPEMENT, Le Ple...

1. A bone screw comprising:a screw body comprising a proximal end, a distal end, a longitudinal axis and a thread along an exterior of all or a portion of said screw body;
a screw head attached to the proximal end of the screw body;
a through bore extending coaxially through said screw head and through said screw body through the proximal end and through the distal end;
at least three blind channels angularly-disposed around the through bore; said channels extending longitudinally through said screw head and through a portion of said screw body; and each of said blind channels being configured to receive a catheter or a needle;
a plurality of radially-disposed fenestrations; wherein a distal portion of each of said blind channels is connected to the exterior of said screw body through at least one of the fenestrations; and
flexible directing means secured to the screw head such that an extracting tool may be guided to the screw head along said means.

US Pat. No. 10,188,415

FORCEPS AND FORCEPS UNIT

MASANORI ISHII, Kofu-Shi...

1. A forceps for gripping tissue, the forceps comprising:a rod-like tubular shaft having a penetrating hole formed in an axial direction;
a rod-like inserted member inserted inside the tubular shaft and being movable in the axial direction inside the tubular shaft;
a gripping portion provided at a distal end of the inserted member and coupled to a distal end of the tubular shaft, the gripping portion including a pair of gripping members capable of opening and closing, each of the gripping members having a distal end portion that applies a force for gripping on the tissue and a pulling portion to which the force for gripping is applied via movement of the inserted member;
a handle coupled to a terminal end of the inserted member; and
a fixing portion detachably fixing the handle to the tubular shaft in a state where the handle is coupled to the inserted member; and
wherein a main body of the tubular shaft includes a mid-section of the tubular shaft between a terminal end of the tubular shaft and the distal end of the tubular shaft,
wherein the distal end of the tubular shaft has a larger diameter than a diameter of the terminal end of the tubular shaft and a diameter of an entirety of the main body of the tubular shaft,
wherein the distal end of the tubular shaft is coupled to a connecting portion at a terminal end of the gripping portion,
wherein a joint portion, having a smaller diameter than the diameter of the entirety of the main body of the tubular shaft, is formed at the terminal end of the inserted member, and the handle is provided with a joint receptacle that houses the joint portion and is advanced and retracted by manipulation of the handle,
wherein the fixing portion includes:
a chuck member having an insertion hole formed therein and configured for locking the terminal end of the tubular shaft in the axial direction, and
a fixing ring having an insertion hole formed therein and coupled to a coupling portion provided on the handle, and
wherein the chuck member is fixed by the fixing ring to the handle in a state in which the terminal end of the tubular shaft, with the inserted member inserted therein, is inserted in the chuck member and the fixing ring, the joint receptacle of the handle and the joint portion of the inserted member are coupled, and the chuck member is sandwiched between the fixing ring and the handle,
wherein the chuck member and the fixing ring are separable from the handle, and the distal end of the tubular shaft into which the inserted member is inserted is inserted into the chuck member and the fixing ring separated from the handle, and
wherein the fixing ring is not fixed to the tubular shaft when the fixing ring is separated from the handle.

US Pat. No. 10,188,411

EVERTING BALLOON FOR MEDICAL DEVICES

CALCULA TECHNOLOGIES, INC...

1. A device for removing a kidney stone from a urinary tract in a human or animal subject, the device comprising:a handle;
a retention member slider coupled with the handle;
an elongate, flexible, outer shaft having a distal end and a proximal end, wherein the outer shaft defines a longitudinal axis extending between the distal and proximal ends;
a lumen wall protection member shaft coaxially disposed within the outer shaft;
an inflatable balloon, comprising:
a proximal attachment portion coupled with the distal end of the outer shaft;
a proximal tapered portion immediately adjacent the proximal attachment portion, having a first longitudinal length, measured along the longitudinal axis;
a central cylindrical portion immediately adjacent the proximal tapered portion, having a second longitudinal length, measured along the longitudinal axis;
a distal tapered portion immediately adjacent the central cylindrical portion, having a third longitudinal length, measured along the longitudinal axis; and
a distal attachment portion immediately adjacent the distal tapered portion, coupled with a distal end of the lumen wall protection member shaft,
wherein the second longitudinal length is longer than the first longitudinal length, and the first longitudinal length is longer than the third longitudinal length;
at least one eversion feature configured to facilitate preferential eversion of the distal tapered portion of the inflatable balloon into an inside of the balloon, rather than the proximal tapered portion, wherein the at least one eversion feature comprises a greater thickness of material on the proximal tapered portion as compared to the distal tapered portion; and
an expandable obstruction retention member extending coaxially within the lumen wall protection member shaft and attached proximally to the retention member slider.

US Pat. No. 10,188,381

SUTURE REPAIR DEVICE

Dura Tap LLC, Wayne, PA ...

1. An apparatus, comprising:a handle having a proximal end portion and a distal end portion;
a cartridge having a proximal end portion and a distal end portion, the proximal end portion configured to be removably coupled to the distal end portion of the handle, the distal end portion of the cartridge having a first needle assembly and a second needle assembly each configured to be transitioned between a first configuration and a second configuration, the first needle assembly including a first needle and a first capture member, the second needle assembly including a second needle and a second capture member;
an actuator movably coupled to the handle, the actuator having a first coupling portion operably coupled to the first needle assembly when the cartridge is coupled to the handle and a second coupling portion operably coupled to the second needle assembly when the cartridge is coupled to the handle, the first coupling portion configured to move relative to the handle in response to a first force to transition the first needle assembly from the first configuration in which the first capture member is spaced apart from the first needle to the second configuration in which the first capture member engages the first needle, the second coupling portion configured to move relative to the handle in response to a second force to transition the second needle assembly from the first configuration in which the second capture member is spaced apart from the second needle to the second configuration in which the second capture member engages the second needle; and
a lock operably coupled to the actuator, the lock configured to selectively limit movement of the first coupling portion and the second coupling portion,
wherein the actuator includes a selector coupled to the lock, the selector configured to transition between a first configuration in which the lock limits movement of the second coupling portion and a second configuration in which the lock limits movement of the first coupling portion.

US Pat. No. 10,188,377

SEMI-AUTOMATIC SUTURING MACHINE

Ruchi Patel, Princeton J...

1. A suturing device comprising:a. a driver arm and receiver arm, each comprising a distal end and a proximal end, said driver and receiver arms connected by a hinge at their proximal ends, said hinge being configured to allow said distal ends of said driver arm and said receiver arm to converge and separate through rotation about said hinge while keeping said proximal ends of both arms affixed to each other;
b. one or more suture units capable of securing wound tissue housed in a crimped anchor loading system, said suture units comprising a length of suture material having a proximal end and a distal end, a fixed anchor attached to said proximal end of the suture, and a needle attached to the distal end of the suture;
c. a center assembly attached to the distal end of the receiver arm and in communication with the driver arm, said center assembly comprising, a suture unit loading system, the crimped anchor loading system, a crimped anchor fastening system, and needle disposing system;
d. wherein the driver arm and receiver are configured to be actuated to engage a gear system within the center assembly, thereby driving a suture unit through two edges of tissue until the fixed anchor abuts against the tissue, securing said edges of tissue by fastening a crimped anchor onto the distal end of the suture, disjoining the distal end of the suture from the needle; disposing of the needle.

US Pat. No. 10,188,366

X-RAY IRRADIATION CONTROLLING DEVICE

Rayence Co., Ltd., Gyeon...

1. An X-ray irradiation controlling device comprising:a pre-shot radiography condition determiner determining a radiography condition;
a reference pixel value acquirer acquiring a reference pixel value from a pre-shot radiograph obtained under the pre-shot radiography condition;
an interrelation acquirer acquiring interrelation between a radiography condition and a radiograph signal on the basis of the reference pixel value; and
a main-shot radiography condition determiner determining a main-shot radiography condition using the interrelation,
wherein the radiography condition is a radiation dose, and
wherein the main-shot radiography condition determiner determines the main-shot radiography condition such that the reference pixel value shows a desired target pixel value in a main-shot radiograph obtained under the main-shot radiography condition.

US Pat. No. 10,188,364

RADIATION IMAGING CONTROL APPARATUS, RADIATION IMAGING APPARATUS, AND STORAGE MEDIUM STORING PROGRAM

CANON KABUSHIKI KAISHA, ...

1. A radiation imaging control apparatus comprising:a managing unit configured to, in a case where a radiation imaging apparatus performs wireless communication, manage whether to operate the radiation imaging control apparatus controlling the radiation imaging apparatus as a master unit or a slave unit; and
an obtaining unit configured to, in a case where the radiation imaging control apparatus operates as the slave unit when performing the wireless communication with the radiation imaging apparatus, obtain reception information of radio wave in the radiation imaging control apparatus,
wherein at least one of the managing unit and the obtaining unit is implemented by a central processing unit, a memory and a communication circuit.

US Pat. No. 10,188,359

INTRA-ORAL SENSOR, CRADLE, AND INTRA-ORAL SENSING SYSTEM

Rayence Co., Ltd., Gyeon...

1. An intra-oral sensing system, comprising:an intra-oral sensor including a data connector transmitting projection data and a charging connector receiving electric power for charging; and
a cradle providing a mounting space to mount the intra-oral sensor therein, the cradle including: a data receiving terminal configured to transmit the projection data, a charging terminal configured to supply the electric power, and a sterilizer sterilizing the intra-oral sensor wherein the data receiving terminal is connected to the data connector and the charging terminal is connected to the charging connector while the intra-oral sensor is in the mounting space.

US Pat. No. 10,188,348

PARAMETER UPGRADE SYSTEM

Masimo Corporation, Irvi...

1. A parameter upgrade system comprising:a handheld upgrade tool; and
a physiological monitor comprising:
a first sensor port configured to attach and communicate with a sensor; and
a processor board in communication with the first sensor port, the processor board comprising:
a monitor digital signal processor (DSP) configured to:
determine that the handheld upgrade tool of a plurality of handheld upgrade tools is attached to the physiological monitor via the first sensor port,
authenticate the handheld upgrade tool for the physiological monitor by verifying that the handheld upgrade tool is authorized to access the physiological monitor, and
identify a tool type of the handheld upgrade tool, and
a plurality of firmware instructions residing on the processor board, wherein a first set of the plurality of firmware instructions is made available to and is executable by the monitor DSP so as to cause the sensor to emit a plurality of wavelengths of light, receive a sensor signal from the sensor in response to absorption of the plurality of wavelengths of light by a patient, and calculate a plurality of physiological parameters in response to the sensor signal received from the sensor, wherein a second set of the plurality of firmware instructions relating to calculation of at least one additional physiological parameter is not made available to the monitor DSP,
wherein the handheld upgrade tool is different from the sensor and individually attachable to the first sensor port in lieu of the sensor, the handheld upgrade tool comprising:
a tool DSP configured to:
authenticate the physiological monitor for the handheld upgrade tool by verifying that the physiological monitor is authorized to access the handheld upgrade tool,
identify a board type of the processor board, and
based on a determination that the board type of the processor board matches the tool type of the handheld upgrade tool, provide changes to the plurality of firmware instructions residing on the processor board, wherein the changes to the plurality of firmware instructions make available to the physiological monitor the second set of the plurality of firmware instructions relating to the calculation of the at least one additional physiological parameter in response to the sensor signal received from the sensor;
a sensor port connector that mates directly with the first sensor port and provides a communications path between the tool DSP and the monitor DSP; and
an I/O port connector different from the sensor port connector and configured to provide a communications path between the tool DSP and an external digital device different from the physiological monitor,
wherein the sensor and the handheld upgrade tool attach to the first sensor port individually at distinct time intervals.

US Pat. No. 10,188,339

URINE MEASUREMENT DEVICE AND METHOD

OBSERVE MEDICAL APS, Kon...

1. A method for treating a luminal surface of a urine handling system, comprisingproviding a capsule in a luminal space of the urine handling system, the capsule comprising a capsule wall defining a space filled with an oil mixture having a viscosity of at most 600 cSt and comprising 90-100° of an oil selected from a group consisting of silicone fluids, mineral oils, and a mixture thereof,
wherein the capsule wall is made of a water-soluble material that disintegrates when exposed to a urine flow such that the oil mixture contacts the luminal surface,
wherein the capsule is arranged upstream of a measurement chamber of the urine handling system, or in an upstream portion of the chamber.

US Pat. No. 10,188,307

SHIELDED MULTI-CHANNEL EEG HEADSET SYSTEMS AND METHODS

Bio-Signal Group Corp., ...

1. An EEG sensor headset comprising:a plurality of electrodes;
an elongated central strip defining one or more electrode-ports and including at least some of the plurality of electrodes and a first connector, the elongated central strip being sized to cover at least a portion of a center line from a nasal bridge to a spinal column of a patient, and being at least partially coated with a first adhesive on a patient side;
an anterior member including a first left wing and a first right wing, each of the first left wing and the first right wing extending from the central strip, the first left wing and the first right wing each having at least two of the plurality of electrodes, at least a portion of the anterior member being coated with the first adhesive on the patient side; a left-end portion of the first left wing and a right-end portion of the first right wing being coated with a second adhesive on the patient side;
a second anterior member including a second left wing and a second right wing each having an electrode of the plurality of the electrodes, each of the second left wing and the second right wing extending from the central strip; at least a portion of the second anterior member being coated with the first adhesive on the patient side, a left-end portion of the second left wing and a right-end portion of the second right wing being coated with the second adhesive on the patient side;
a right side member extending from the central strip and including an electrode of the plurality of electrodes, at least a portion of the right side member being coated with the first adhesive on the patient side;
a right contact member coupled to the right side member by a first lateral flex joint, the right contact member being coated with the second adhesive on the patient side;
a left side member extending from the central strip and including an electrode of the plurality of electrodes; a portion of the left side member being coated with the first adhesive on the patient side;
a left contact member coupled to the left side portion by a second lateral flex joint, the left contact member being coated with the second adhesive on the patient side;
a posterior member coated with the first adhesive on the patient side, the posterior member including:
a third left wing extending from the central strip and having at least three of the plurality of electrodes on the patient side, and an upper and a lower external adhesion location coated with the second adhesive on an outer side opposite the patient side, and
a third right wing extending from the central strip and having at least three of the plurality of electrodes on the patient side, and an upper and a lower external adhesion location coated with the second adhesive on the outer side;
the first connector disposed between the anterior member and the posterior member, the first connector electrically coupled to at least some of the plurality of electrodes by respective traces, the first connector including a terminal corresponding to respective electrodes; and
a shield plane including at least a portion coupled to the central strip, the shield plane coupled to a flexible outer substrate opposite the patient side, the flexible outer substrate providing a dielectric material disposed between the shield plane and the plurality of electrodes.

US Pat. No. 10,188,303

HEMODYNAMIC MONITOR AND METHOD OF HEMODYNAMIC MONITORING

LIDCO Group PLC, London ...

1. An apparatus for determining stroke volume comprising:an input for receiving an arterial pressure waveform;
means arranged to define a start point within the arterial pressure waveform at a beginning of a systolic arterial pressure increase due to a ventricular contraction phase of a heart beat;
means arranged to determine an end point of the heart beat for the purpose of calculating stroke volume by
determining whether there is a part or point of the arterial pressure waveform that has substantially the same arterial pressure value as said starting point,
responsive to said arterial pressure value at said starting point being regained, setting the end point to be the part or point of the arterial pressure waveform that has substantially the same arterial pressure value as said starting point, and
responsive to said arterial pressure value at said starting point not being regained, extrapolating the end point of the heart beat to a point where the arterial pressure waveform has substantially the same arterial pressure value as said starting point to define the end point;
means arranged to calculate a stroke volume from a part of the arterial pressure waveform or of the extrapolated arterial pressure waveform between the start point and the end point; and
an output means and configured to output, via the output means, an indication of at least one of a current stroke volume, a current heart rate, a number of previous stroke volumes and a number of previous heart rates.

US Pat. No. 10,188,299

SYSTEM CONFIGURED FOR MEASURING PHYSIOLOGICAL PARAMETERS

Omni Medsci, Inc., Ann A...

1. A system comprising:a light source comprising a plurality of light emitting diodes, each of the light emitting diodes configured to generate an output optical beam having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
a lens positioned to receive at least a portion of at least one of the output optical beams and to deliver a lens output beam to tissue;
a detection system located to receive at least a portion of the lens output beam reflected from the tissue and configured to generate an output signal based on the received portion of the lens output beam reflected from the tissue, the output signal having a signal-to-noise ratio, wherein the detection system is further configured to be synchronized to the light source;
a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor, and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link; and
a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data, and to store the processed data;
wherein the output signal is indicative of one or more physiological parameters, and the remote device is configured to store a history of at least a portion of the one or more physiological parameters over a specified period of time;
the light source configured to improve the signal-to-noise ratio of the output signal by increasing light intensity relative to an initial light intensity from at least one of the plurality of light emitting diodes and by increasing pulse rate relative to an initial pulse rate of at least one of the plurality of light emitting diodes;
wherein the detection system includes a plurality of spatially separated detectors, wherein at least one analog to digital converter is coupled to at least one of the spatially separated detectors and is configured to generate at least two data signals, and the system is configured to further improve the signal-to-noise ratio by differencing two of the at least two data signals; and
wherein the detection system further comprises one or more spectral filters positioned in front of at least some of the plurality of spatially separated detectors.

US Pat. No. 10,188,294

ADAPTER FOR RETINAL IMAGING USING A HAND HELD COMPUTER

Verana Health, Inc., San...

1. An adapter configured to engage with a hand held computer device with a camera having an optical axis comprising:an anterior adapter portion comprising: a body, a clamp configured to engage with the hand held computer device at a first location and a second location, a lens holder engaged with a macro lens movable between a first position in the optical axis of the camera and a second position outside of the optical axis of the camera, an adjustable light source with a light axis parallel to a macro lens optical axis, a third engagement surface configured to slidably engage with the hand held computer device at a third location, and a complementary surface of the body configured to reversibly engage with a base section of a posterior portion, wherein the clamp defines an axis and the body of the anterior adapter portion is configured to move along the axis of the clamp; and
the posterior portion comprising: the base section configured to reversibly engage with the complementary surface of the body of the anterior adapter portion, a telescoping section movable relative to the base section, and a lens holder engaged with a distal end of the telescoping section configured to removably engage with an ophthalmoscopy lens, the base section configured to removably engage with the body of the anterior adapter portion to form an optical axis between the ophthalmoscopy lens and the camera of the hand held computer device.

US Pat. No. 10,188,279

DISPOSABLE, SELF-CONTAINED LARYNGOSCOPE AND METHOD OF USING SAME

Adroit Surgical, LLC, Ok...

1. A laryngoscope comprising:a tube having an outer surface, an inner surface, a distal end and a proximate end defining a lumen there through, said tube having a longitudinal channel positioned about the circumference of said tube and extending from the outer surface thereof to the inner surface thereof for guiding light from its proximate end to its distal end;
a handle assembly and a power source mounted within said handle assembly, said handle assembly having a distal end and a proximate end wherein said proximate end is adapted to releasably attach to an optical subassembly; and
said optical subassembly comprising a light source for coupling to the power source and a housing supporting the light source, said light source positioned to supply light into the longitudinal channel.

US Pat. No. 10,188,254

AUTONOMOUS PLANAR SURFACE CLEANING ROBOT

ECOVACS ROBOTICS, INC., ...

1. A planar surface cleaning apparatus, comprising:a main body having a top portion and a bottom portion, the bottom portion defining an outer portion defining a surface area about a perimeter thereof and an inner portion defining a cavity formed within the outer portion;
at least one vacuum source supported by the main body and in fluid communication with the cavity;
a cleaning component disposed over the surface area defined on the outer portion of the bottom portion of the main body; and
a connector pole comprising:
a handle portion; and
a U portion connected to the handle portion, wherein the U portion is pivotally connected to the main body.

US Pat. No. 10,188,243

ADAPTER FOR RECESSED PAPER PRODUCT DISPENSERS

Solaris Paper, Inc., Alp...

1. An adapter assembly for a recessed dispenser having a cavity, wherein the cavity comprises first and second opposing sidewalls, respectively, the adapter assembly comprising:right and left vertical walls sized and dimensioned to fit within the first and second opposing sidewalls of the cavity;
a fastener for removably coupling at least one of the right and left vertical walls of the adapter assembly to at least one of the first and second opposing sidewalls of the cavity, respectively;
first and second parallel arms fixedly attached to the right and left vertical walls, respectively, and extending outwardly from the right and left vertical walls to a first and second distance, respectively;
first and second receivers removably coupled to the first and second parallel arms, respectively, wherein the first and second receivers are disposed within the first and second distance, respectively;
wherein the first and second receivers have first and second cups, respectively, for receiving first and second ends of a spindle; and
wherein the first and second cups are disposed within the first and second distance, respectively.

US Pat. No. 10,188,239

GRILLING TOOL

Holton Products LLC, For...

1. A tool, comprising:tongs having arms, a handle on each of the arms, and a hinge that pivotally connects the arms to each other, the arms are configured to be moved between a closed position wherein distal ends of the arms are in proximity to each other, an open position wherein the distal ends of the arms are spaced apart from each other, and one of the arms is larger than the other of the arms such that the tongs are not symmetric;
a flashlight mounted to an interior of the tongs inside a cavity in one of the handles, the flashlight having an electrical switch that is configured to be accessed from an exterior of the tongs via an aperture in the one of the handles and actuated between on and off positions, the electrical switch is positioned and configured to be actuated by a thumb of a user when the tongs are held in one hand by the user, and the flashlight comprises a body with a body axis, a head at a distal end of the body, and the head comprises a head axis that is not co-axial with the body axis; and
the tool comprises a spring clip opposite the electrical switch, the flashlight has an installed position wherein the flashlight is secured to the tool, the spring clip is releasably coupled to one of the flashlight or the one of the handles such that the spring clip is captured in an aperture of the flashlight or an aperture in an interior of the one of the handles, the flashlight also comprises a released position wherein the spring clip is configured to be actuated such that the flashlight is slidably removable from the tool.

US Pat. No. 10,188,234

CHRISTMAS TREE MOISTURE SENSOR

Belac Products, LLC, Lew...

1. A moisture sensor comprising:a housing adapted to mount onto a tree stem,
a probe attached to the housing and adapted to detect water levels in a tree stand, the probe detects the conductivity of water to determine the water level,
a conductive rod with insulators at each opposing end wherein the probe is
separated by one insulator at a first end of the conductive rod and the other end of the conductive rod is inserted into the housing,
a PC board within the housing for determining water levels in the tree stand, a LED indicator adapted to provide a visual signal when water levels are below a threshold in the tree stand, and
a speaker adapted to provide an audio signal when water levels are below the threshold in the tree stand,
wherein the LED indicator signals the visual alert and the speaker signals the audio alert when the probe detects that the water level is below a threshold,
wherein the probe detects the conductivity of water to determine the water level,
wherein the probe comprises a copper wire connected at one end to the PC board, and an opposing end capped by a conductive shield, and
further including a silicone insulator on the other end of the conductive rod adapted to provide a water-tight seal between the conductive rod and the housing.

US Pat. No. 10,188,218

FURNITURE DEVICE WITH ADJUSTABLE FIRMNESS

You Bed AB, Nacka (SE)

1. A furniture device configured to receive the weight of a being, said furniture device having a holding arrangement and at least one section comprising a base, a movable plate element, a moving mechanism and at least one elastic device, the plate element being configured to interact with the at least one elastic device and to be moved by the moving mechanism in respect to the base in order to adjust the firmness of the at least one elastic device, the elastic device comprising a pocket made of a fabric, and an elastic member, the elastic member being arranged within said pocket, the pocket being attached to adjacent pockets whereby the attachment is formed so that adjacent elastic devices may move independently from one another along a first distance, as measured from a free end of the elastic device and in a direction perpendicular to the plate element, the holding arrangement comprising a connecting portion and a holding member, which is connected to the at least one elastic device via the connecting portion, such that the at least one elastic member is compressed and relaxed respectively over its entire length during movement of the plate element upwards and downwards, the connecting portions being arranged on a straight line, which extends through the center of two or more attached elastic devices characterized in that the holding member is a flexible thread or string, which extends from the base to directly connect to each connecting portion and back from the connecting portion to the base thereby forming a V-shape with peaks and valleys.

US Pat. No. 10,188,202

BROOM WITH REPLACEABLE BRUSH CARTRIDGE

Bradshaw International, I...

1. A broom with a replaceable brush cartridge comprising:a broom head comprising a top side having a pole receiver for attachment to a pole and a bottom side having a retention skirt;
a track disposed along an inner wall of the retention skirt;
a cartridge receiver formed by the surrounding retention skirt;
a wedge retainer located within the cartridge receiver;
a brush cartridge having an elongated shape and a perimeter groove capable of receiving the track of the broom head;
bristles affixed to the brush cartridge;
a wedge with a live hinge connecting the wedge with the brush cartridge;
the wedge positioned to engage with the wedge retainer of the cartridge receiver when the brush cartridge is installed in the cartridge receiver of the broom head.

US Pat. No. 10,188,188

HEADBAND WITH A 360-DEGREE ELASTIC OUTSIDE PORTION JOINED WITH A 360-DEGREE VELVET INSIDE LINING

Sparkly Soul, Inc., West...

1. A 360 degree headband consisting of:an outer layer, the outer layer formed of a single piece of material formed in a loop, a first end of the single piece of material being connected to a second end of the single piece of material at a seam, wherein the entire loop of the outer layer exhibits a uniform elasticity, and wherein the entire loop of the outer layer has a uniform width; and
an inner layer consisting of a piece of velvet material attached to the outer layer la stitching, wherein the inner layer exhibits elasticity, wherein a long axis of the piece of velvet material is aligned with a long axis of the single piece of material of the outer layer,
wherein the entire 360 degrees of the headband exhibits elasticity.

US Pat. No. 10,188,183

AMBULATORY AID

Aligned As Designed, LLC,...

1. An ambulatory aid comprising:an elongate, straight shaft;
a handle coupled to a first end of the shaft at a fixed angle; and
a foot piece coupled to a second end of the shaft at a fixed angle,
wherein the first end of the shaft is coupled to the handle such that a posterior portion of the handle extends from the shaft at a length greater than an anterior portion of the handle, and the second end of the shaft is coupled to the foot piece such that an anterior portion of the foot piece extends from the shaft at a length greater than a posterior portion of the foot portion, and wherein the shaft extends at an angle between the handle and the foot piece when measured from a horizontal surface.

US Pat. No. 10,188,175

BUCKLE ASSEMBLY AND RESPIRATORY MASK INCLUDING THE SAME

BESMED HEALTH BUSINESS CO...

1. A buckle assembly adapted for use in a respiratory mask, the respiratory mask including a mask body, said buckle assembly comprising:a female part adapted to be fixed to a side of the mask body, and including top and bottom walls and a curved vertical wall that extends between said top and bottom walls in a vertical direction and that cooperates with said top and bottom walls to define a first open recess thereamong, said top wall being formed with a top pivot hole and a top guiding groove that extends away from a periphery of said top pivot hole, said bottom wall being formed with a bottom pivot hole and a bottom guiding groove that extends away from a periphery of said bottom pivot hole, said bottom guiding groove being aligned with said top guiding groove along the vertical direction, said bottom pivot hole being aligned with said top pivot hole along the vertical direction, said curved vertical wall having a free end that extends between said top and bottom walls; and
a male part including an arm section and a hook section,
wherein the arm section includes a major surface that defines a plane and the hook section extends curvedly from said arm section about an axis substantially parallel to said plane such that an inner surface of a free end of the hook portion faces said plane whereby said hook section is U-shaped and defines a second open recess,
wherein the free end of the hook section is insertable into said first open recess in said female part, said free end of said hook section being formed with top and bottom pivot protrusions that are aligned with each other along the vertical direction and that are respectively slidable along said top and bottom guiding grooves into said top and bottom pivot holes, respectively, so as to bring said male part to detachably pivot relative to said female part between a first angular position, in which said free end of said curved vertical wall is disposed outwardly of said second open recess, and a second angular position, in which said free end of said curved vertical wall is disposed in said second open recess and in which said curved vertical wall and said hook section hook to each other,
and wherein upper and lower U-shaped slits are formed substantially parallel to and spaced apart from one another in the hook section and extending through said free end of said hook section to define within said hook section a center hook portion and an outer hook portion spaced apart from each end of the center hook portion, the center hook portion and outer hook portions each being curved about said axis, so as to permit elastic deformation of said free end of said hook section during insertion of said top and bottom pivot protrusions into said top and bottom pivot holes, said top and bottom pivot protrusions being removable respectively from said top and bottom pivot holes when said male part is pivoted from the second angular position to the first angular position.

US Pat. No. 10,188,171

ALIGNMENT SYSTEM FOR A CLEAT AND BASE ASSEMBLY

Speedplay, Inc., San Die...

1. A bicycle cleat assembly configured to be disposed on an underside of a shoe sole, the bicycle cleat assembly comprising:a forward cleat edge and a rearward cleat edge separated at a distance along a longitudinal axis of the bicycle cleat assembly, each of the forward cleat edge and rearward cleat edge having:
a center portion spanning the longitudinal axis, and opposing left and right ends;
opposing left and right sides connecting the forward cleat edge and the rearward cleat edge; and
a pair of guides, each extending from one of the opposing left and right ends of the forward cleat edge to define an expanded landing region for a bicycle pedal;
wherein each of the pair of guides extends forwardly beyond a forwardmost edge of the center portion of the forward cleat edge;
wherein each of the pair of guides further extends outwardly from one of the opposing left and right sides of the bicycle cleat assembly; and
wherein each of the pair of guides extends outwardly at an angle of from 95 degrees to 180 degrees from the forward cleat edge.

US Pat. No. 10,188,156

ASYMMETRIC ATHLETIC APPAREL AND METHODS OF USE THEREFOR

NEW BALANCE ATHLETICS, IN...

1. An asymmetric garment for at least a portion of an upper body of a wearer, the garment comprising:a torso section extending around a torso portion of the upper body of the wearer;
a first sleeve connected to the torso section at a first seam and comprising a first arm region at least partially covering a first arm of the wearer; and
a second sleeve connected to the torso section at a second seam and comprising (i) a second arm region at least partially covering a second arm of the wearer and (ii) a second shoulder region covering at least a portion of a second shoulder of the wearer, the second shoulder region comprising a front section and a back section that each extend only partially over a torso of the wearer proximate the second arm region, wherein the second seam is arranged asymmetrically with respect to the first seam so as to provide reduced resistance to asymmetrical shoulder and arm motion at the second shoulder region, and wherein the garment further comprises:
a single expanse of material comprising first and second material portions joined at the second seam, a combination of which further results in the asymmetrical garment providing, at a body portion subject to resistance, reduced resistance to asymmetrical shoulder and arm motion,
the first material portion comprising a first material, the first material portion comprising at least a portion of the torso section extending from the second seam to the first seam; and
the second material portion comprising a second material differing in at least one material property from the first material and adapted to provide reduced resistance to asymmetrical shoulder and arm motion at the second shoulder region, the second material portion comprising a single unitary expanse of material, extending from the second seam and comprising the shoulder region and at least a portion of the second arm region of the second sleeve and, at the second arm region, extending completely around the second arm of the wearer.

US Pat. No. 10,188,155

GARMENT COMPRISING A MODULE WITH A REMOVABLE ELECTRONIC DISPLAY, FASTENED TO THE GARMENT THROUGH SUPPLE MAGNETIC MEANS

WEAR TRBL, Paris (FR)

1. A unit, in particular a garment, comprising:a supple-sheet support (100), in particular a textile support, including a cut-out (102) formed in an apparent region;
a flat electronic module (200), whose peripheral perimeter (202) is similar to the perimeter of the cut-out (102), and whose dimensions are greater than those of the cut-out so as to define with the latter an overlapping peripheral region (204), this module being arranged on an inner side of the support and comprising a circuit (208) supporting electronic components (212) and a display (206) visible from an outer side of the support, through the cut-out; and
magnetic means for attaching the module to the support when the module and the support are arranged opposite to each other in the overlapping peripheral region,characterized in that:the circuit (208) supporting electronic components (212) and the display (206) is a flexible circuit;
the support (100) comprises, around the cut-out at the inner side, a peripheral band (130) carrying a first magnetization pattern with ranges (132, 134, 136, 138) magnetized alternatively with a given magnetic polarity and with a reverse magnetic polarity; and
the module (200) includes at the periphery thereof a frame (230), of dimensions similar to those of the peripheral band of the support, carrying a second magnetization pattern with ranges (232, 234, 236, 238) magnetized alternatively with a given magnetic polarity and with a reverse magnetic polarity,
the second magnetization pattern being a reverse pattern, conjugated with respect to the first magnetization pattern, when the module and the support are arranged opposite to each other in the overlapping peripheral region.

US Pat. No. 10,188,148

ELECTRONIC NICOTINE DELIVERY SYSTEM

McNeil AB, Helsingborg (...

1. A system for generating a vapor from a liquid comprising:a) an electric heater having a body comprising at least one sidewall that defines an interior void, at least one inner surface, at least one outer surface, and a plurality of apertures through the at least one sidewall, the electric heater comprising an electrically resistive material contained within a heat diffusing material;
b) an elongate wick having a longitudinal axis, a first end, a second end, and an outer surface, the elongate wick comprising a durable elongate structure having a plurality of liquid-conducting features on the outer surface;wherein at least a portion of the liquid-conducting features of the elongate wick proximate the first end engage at least a portion of the at least one inner surface of the electric heater and at least a portion of the liquid-conducting features of the elongate wick are capable of conducting the liquid from a source proximate the second end of the wick along the outer surface of the elongate wick to the electric heater.

US Pat. No. 10,188,143

DISPLAY PACKAGES, BLANKS FOR FORMING TRAP SEAL CARD AND BLANK FOR FORMING DISPLAY BOX

Altria Client Services LL...

1. A display package, comprising:a first packaging including a first compartment configured to hold a first item;
a second packaging including a second compartment configured to hold a second item; and
a trap seal card including a first opening, the trap seal card retaining the first packaging and the second packaging such that
the first item and the second item to be held within the first compartment and the second compartment are visible to a consumer through the first opening, and
a portion of each of the first packaging and the second packaging protrudes through the first opening,
the trap seal card including a front panel integral with a back panel, the front panel consisting essentially of,
a first panel including the first opening, and
second, third and fourth panels, collectively, forming a third compartment in conjunction with the back panel, the third compartment protruding from a surface of the back panel, and
a portion of each of the first packaging and the second packaging being interposed between the front panel and the back panel.

US Pat. No. 10,188,142

AMPHIPHILE-MODIFIED SORBENTS IN SMOKING ARTICLES AND FILTERS

Philip Morris USA Inc., ...

1. A smoking article comprising an amphiphile-modified sorbent having at least one amphiphilic compound selected from the group consisting of an imidazoline, an ethoxylated amine, and a quaternary phospholipid bound to an inorganic molecular sieve substrate.

US Pat. No. 10,188,136

HYDROPHOBIN MIMICS: PROCESS FOR PREPARATION THEREOF

INDIAN INSTITUTE OF SCIEN...

1. A hydrophobin mimic of Formula I for use in bio-nano technology:
comprising;
a hydrophilic protein head group PROT having a length of up to 500 amino acids, selected from the group consisting of serine proteases, cysteine proteases, aspartic proteases, metalloproteases, trypsin, chymotrypsin, subtilisin, proteinase K, and mixtures thereof;
a hydrophilic spacer comprising a phosphonate ester of an ethylene glycol oligomer, wherein ‘n’ is an integer 1-30; and
a hydrophobic tail of formula II,

wherein “R/H” represents either H or a C4-C20 (un)substituted or substituted straight, branched, cyclic, or acyclic aliphatic moiety; an aromatic moiety; or an alkylphenyl moiety, wherein at least one R/H is not H.

US Pat. No. 10,188,117

NOODLE STRING TREATMENT APPARATUS AND TREATMENT METHOD

NISSIN FOODS HOLDINGS CO....

1. A noodle string treatment method, comprising steps of:conveying a batch of noodle strings;
cutting the batch of noodle strings at a constant cutting time interval by using a rotary blade that has a flat shape, is attached to a rotating shaft and extends out from the rotating shaft; and
extruding the cut batch of noodle strings by the rotary blade, wherein:
a blade edge of the rotary blade extends along a direction in which the rotating shaft extends,
the rotary blade cuts the batch of noodle strings at a cutting point, which is a point where the blade edge of the rotary blade is closest to or comes into contact with an outer circumferential surface of an oppositely disposed roller,
in the step of cutting the batch of noodle strings, a blade edge peripheral speed of the rotary blade is changed during rotation thereof between a cut and a next cut,
in the step of cutting the batch of noodle strings, the batch of the noodle strings is cut at a position where a lengthwise direction of the batch of noodle strings extends in a vertical manner,
the rotary blades comprises a plurality of rotary blades attached to the rotating shaft,
in the step of cutting the batch of noodle strings, the blade edge peripheral speed of the plurality of rotary blades is changed periodically with a constant time interval over a plurality of cycles, wherein each of the plurality of cycles is a time period from one cutting timing by one of the plurality of rotary blades to a next cutting timing by another of the plurality of rotary blades cutting the batch of the noodle strings subsequent to the one of the plurality of rotary blades, and
the blade edge peripheral speed when one rotary blade among the plurality of rotary blades extrudes the cut batch of noodle strings after the one rotary blade cuts the batch of noodle strings is set to be lower than the blade edge peripheral speed of the rotary blade when the one rotary blade cuts the batch of noodle strings.

US Pat. No. 10,188,094

BREATH-POWERED VAPOR DISTRIBUTION DEVICE

Wyndscent, LLC, Belmont,...

1. A scent material distribution device that uses a person's exhaled breath as an airflow that distributes the scent material from the device; the device comprising:a body having an inlet and an outlet;
the body defining an airflow channel extending from the inlet to the outlet;
a power source;
a liquid scent material supply;
an electric burner that is selectively powered by the power source to rapidly vaporize a liquid scent material from the liquid scent material supply;
the electric burner being in fluid communication with the airflow channel at a first location such that vapor created by the burner can be distributed from the outlet;
a one-way valve;
the one-way valve being disposed along the airflow channel between the inlet and the first location; the one-way valve preventing vaporized scent material from the electric burner from being inhaled by the user through the inlet; the one-way valve allowing exhaled breath to flow from the inlet to the outlet; and
the first location being disposed along the airflow channel intermediate the one-way valve and the outlet such that exhaled breath passes through the one-way valve to move the vaporized scent material along the airflow channel to the outlet.

US Pat. No. 10,188,049

CUSTOMIZED CROP MODELING

CropMetrics LLC, North B...

1. A crop modeling system comprising:an irrigation system; and
a user input device communicatively coupled to the irrigation system via a communication connection,
wherein the irrigation system and the user input device are configured to communicate with a processor and a non-transitory memory with one or more executable instructions stored thereon, wherein the processor is configured to execute the one or more executable instructions, wherein the one or more executable instructions are configured to cause the processor to:
open a crop modeling graphical user interface for a geospatial location of a field associated with the irrigation system, wherein the crop modeling graphical user interface includes a crop model for the geospatial location of the field;
move a crop graphical user interface element to a mapped location on the crop modeling graphical user interface responsive to one or more user inputs received via the user input device, wherein the one or more user inputs correspond to the geospatial location of the field, wherein the one or more user inputs at least partially include data obtained during an in-season timeframe;
generate an in-season crop model by applying the one or more user inputs to the crop model via the moving of the crop graphical user interface element, wherein the in-season crop model includes one or more forecasted water application rates for the geospatial location of the field;
store the in-season crop model as a list of one or more updates made to the in-season crop model, wherein a history of the one or more updates is retrievable via an access point; and
generate one or more control signals based on the in-season crop model, wherein the one or more control signals are configured to adjust one or more components of the irrigation system.

US Pat. No. 10,188,031

CUTTER BLADE AND ASSEMBLY FOR A ROTARY CUTTER

Great Plains Manufacturin...

1. A blade assembly for a rotary cutter, said blade assembly comprising:an elongated blade carrier rotatably connected to the rotary cutter;
at least a first cutter blade and a second cutter blade, with one of said cutter blades secured to each opposite side of said blade carrier, wherein rotation of said blade carrier causes a corresponding rotation of said cutter blades;
an elongated base element secured below said blade carrier, wherein said cutter blades are sandwiched between said blade carrier and said base element;
a pair of elongated stop surfaces associated with said first cutter blade, wherein each of said elongated stop surfaces is configured to engage with a length of a side of said first cutter blade to inhibit rotation of said first cutter blade with respect to said blade carrier; and
a pair of elongated stop surfaces associated with said second cutter blade, wherein each of said elongated stop surfaces is configured to engage with a length of a side of said second cutter blade to inhibit rotation of said second cutter blade with respect to said blade carrier.
US Pat. No. 10,188,132

REFINED PLANT ISOLATES AND PROCESS FOR THE MANUFACTURE OF A FUNCTIONAL FOOD INGREDIENT FROM SUCH PLANT ISOLATE

Conopco Inc., Englewood ...

1. A process of preparing a functional food ingredient, said process comprising:a) providing an aqueous plant extract containing particles of plant material;
removing from the aqueous plant extract more than 50 vol. % of particles comprising a size of at least 2 ?m to produce a crude serum having at least 2° Brix, wherein not more than 40 vol. % of the particles in the crude serum have a diameter larger than 2 ?m;
removing Ca2+ and Mg2+ from the crude serum to produce the refined plant isolate, wherein a reduction of Ca2+ and Mg2+ in the refined plant isolate reduces a need to regenerate columns used in ion exclusion chromatography of step b)
wherein the refined plant isolate comprises:
a concentration of 40° Brix;
at least 0.2 wt % of glutamate;
at least 500 ppm of K+;
less than 300 ppm of Ca2+;
less than 700 ppm of Mg2+;
less than 1 wt. % of components incapable of passing an ultra-filtration membrane having a molecular weight cut off of 250 kDa;
a concentration ratio ([Ca2+]+[Mg2+])/[K+] that does not exceed 5:100, wherein the [Ca2+], [Mg2+] and [K+] are expressed in ppm;
wherein the concentration ratio ([Ca2+]+[Mg2+])/[K+] of the refined plant isolate is at least 2 times lower than a concentration ratio ([Ca2+]+[Mg2+])/[K+] expressed in ppm of the aqueous plant extract;
b) subjecting the refined plant isolate to ion exclusion chromatography by using columns; and
c) collecting at least a part of an eluate of the ion exclusion chromatography as the functional food ingredient or an intermediate for the process of preparing the functional food ingredient; wherein the functional food ingredient or the intermediate comprises:
at least 30% by weight of dry matter of water soluble plant components selected from fructose, glucose, proteinaceous matter of plant origin, acids and potassium;
a weight ratio glutamate:citrate of at least 5 times higher than in the refined plant isolate;
and/or a weight ratio glutamate:glucose of at least 10 times higher than in the refined plant isolate.
US Pat. No. 10,190,955

SYSTEMS AND METHODS FOR DETERMINING THE EFFECTIVE TOUGHNESS OF A MATERIAL AND FOR IMPLEMENTING MATERIALS POSSESSING IMPROVED EFFECTIVE TOUGHNESS CHARACTERISTICS

California Institute of T...

10. An elastically heterogeneous material comprising:at least a first region comprising a first material characterized by a first elastic modulus;
a plurality of inclusions comprised of a second material characterized by a second elastic modulus;
wherein the inclusions comprise bodies having asymmetric geometries characterized by specific directionality; and
wherein the presence of the inclusions causes the elastically heterogeneous material to have a directionally asymmetric effective toughness such that the effective toughness of the elastically heterogeneous material is greater than it would be if the material was entirely characterized only by the toughness of either the first or second materials alone.
US Pat. No. 10,188,661

TOPICAL DOSAGE REGIMEN

Topokine Therapeutics, In...

1. A method for locally reducing body fat in a subject in need thereof, the method comprising the steps of: administering a composition comprising latanoprost to the skin surface; and removing the composition or residue thereof from the skin surface between about 4 hours and about 12 hours, inclusive, after said administering;wherein more than about 60 percent of the 24-hour flux of latanoprost or an active metabolite thereof occurs within 4 to 12 hours, inclusive, after the step of administering, and wherein the step of removing is after more than about 60 percent of the 24-hour flux has occurred.
US Pat. No. 10,188,666

DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS

AFFICHEM, Toulouse (FR) ...

1. A method for treating a cancer acute myeloid leukemia which is chemoresistant to an antineoplastic agent in a patient in need thereof comprising administering to said patient 5?-hydroxy-6?-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3?-ol or a pharmaceutically acceptable salt thereof and said antineoplastic agent, wherein said antineoplastic agent is cytarabine.
US Pat. No. 10,189,951

ALIPHATIC POLYIMIDES FROM A 1:2 MOLAR RATION OF DIAMINE AND UNSATURATED MONOANHYDRIDE OR UNSATURATED DIACID

PolyOne Corporation, Avo...

1. An aliphatic polyimide, wherein the aliphatic polyimide is poly-3,3?,4,4?-yl-((1,1?-bis trimethylene-poly dimethyl siloxane-1,?-diyl)-bis-(3-methyl-pyrrolidine-2,5-dione)).
US Pat. No. 10,188,676

ANTI-INFLAMMATORY SOLUTION

Hypo-Stream Limited, Mel...

1. A method for treating an inflammatory response in burns in a mammal comprising administering an effective amount of a dilute stabilized hypochlorite solution to said mammal in need thereof, wherein the dilute hypochlorite solution consists of:(i) water; sodium hypochlorite in a concentration range of 0.05-0.1 wt %; and sodium chloride in a concentration range of 0.5-1.5 wt %; or,
(ii) water; sodium hypochlorite in a concentration range of 0.05-0.1 wt %; sodium chloride in a concentration range of 0.5-1.5 wt %; and an indicator.
US Pat. No. 10,192,024

SYSTEM AND METHOD FOR GENERATION AND USE OF OPTIMAL NUCLEOTIDE FLOW ORDERS

454 Life Sciences Corpora...

1. A method for sequencing a nucleic acid template using a flow order that minimizes the accumulation of phasic synchrony error in sequence data, comprising the steps of:(a) introducing a numerically generated sequential ordering of nucleotide species comprising a k-base length into a sequencing by synthesis reaction environment, wherein the numerically generated sequential ordering of nucleotide species comprises a predetermined series of flows of nucleotide species that is generated by
(i) simulating expected flowgram signals that would be generated using a sequencing by synthesis method to acquire sequence data from one or more known reference sequences, wherein the sequence data comprises an accumulation of phasic synchrony error from the one or more known reference sequences and
(ii) selecting the series of flows of nucleotide species that demonstrates a high read length characteristic and a low extension rate characteristic for the one or more known reference sequences, wherein the high read length characteristic is greater than about 400 bp and the low extension rate characteristic is less than or equal to 0.55 bp/flow;
(b) acquiring signals from the sequencing by synthesis reaction environment in response to incorporation of the nucleotide species in an extension reaction of one or more populations of substantially identical nucleic acid template molecules, wherein the signals comprise a measure of error from a subset of nucleic acid template molecules from one or more of the populations fall behind a phase of extension; and
(c) cyclically repeating the introduction of the numerically generated sequential ordering of nucleotide species and acquisition of signals for a number of iterations, wherein the subset of nucleic acid molecules re-synchronize with the phase of extension that reduces the measure of error due to the high read length characteristic and the low extension rate characteristic of the sequential ordering.
US Pat. No. 10,189,981

HIGH-STRENGTH CROSS-LINKED POLYMER PHOTONIC CRYSTAL FILM

XIAMEN UNIVERSITY, Xiame...

1. A method for preparing a cross-linked polymer photonic crystal film, comprising the steps of:(a) preparing a first emulsion by:
polymerizing a hydrophobic monomer and a hydrophilic monomer having epoxy groups in water to provide a first self-assembled unit of monodispersed polymer microspheres having a hydrophobic core and a hydrophilic shell with surface epoxy groups; and
dispersing the monodispersed polymer microspheres of the first self-assembled unit into water under normal conditions of temperature and pressure to obtain the first emulsion having a concentration of polymer microspheres ranging from 5 wt % to 30 wt %;
(b) preparing a second emulsion by:
polymerizing a hydrophobic monomer and a hydrophilic monomer having carboxyl groups or amino groups in water to provide a second self-assembled unit of monodispersed polymer microspheres having a hydrophobic core and a hydrophilic shell with surface carboxyl groups or surface amino groups; and
dispersing the monodispersed polymer microspheres of the second self-assembled unit into water under normal conditions of temperature and pressure to obtain a second emulsion having a concentration of polymer microspheres ranging from 5 wt % to 30 wt %;
(c) successively coating the first emulsion and the second emulsion onto a flat substrate in any order; and
(d) evaporating the water to enable a self-crosslinking reaction between the surface epoxy groups of the first self-assembled unit and the surface carboxyl groups or the surface amino groups of the second self-assembled unit to form said cross-linked polymer photonic crystal film.
US Pat. No. 10,188,700

USE OF HAPTOGLOBIN SUBUNIT FOR PROMOTING ANGIOGENESIS

TAIPEI MEDICAL UNIVERSITY...

1. A method for promotion of angiogenesis, comprising:administering a modified haptoglobin subunit to a subject in need thereof, the modified haptoglobin subunit comprising an amino acid sequence selected from one of SEQ ID NOs: 1-3.
US Pat. No. 10,188,705

DOSE ESCALATION ENZYME REPLACEMENT THERAPY FOR TREATING ACID SPHINGOMYELINASE DEFICIENCY

Icahn School of Medicine ...

1. A method for treating an acid sphingomyelinase deficiency (ASMD), comprising:a. administering to a human subject in need thereof one or more initial doses of 0.1 mg/kg recombinant human acid sphingomyelinase (rhASM); and
b. administering sequentially escalating higher doses of rhASM to the human subject if the subject does not manifest one or more moderate or severe adverse events, wherein the higher doses are from 0.1 mg/kg to 1.0 mg/kg higher than the previous dose.
US Pat. No. 10,188,725

HYBRID CORE FELINE VACCINES

Elanco US Inc., Greenfie...

1. A non-adjuvanted immunogenic composition comprising:a. Feline Rhinotracheitis virus;
b. Feline Calicivirus;
c. Virulent Systemic Feline Calicivirus; and
d. Feline Panleukopenia virus;
wherein the Feline Calicivirus and the Virulent Systemic Feline Calicivirus are inactivated; and
wherein the Feline Rhinotracheitis virus is attenuated.
US Pat. No. 10,191,033

BIOMARKERS FOR DETECTING PRE-CACHEXIA OR CACHEXIA AND METHODS OF TREATMENT THEREOF

The Broad Institute, Inc....

1. A method of treating pre-cachexia in a subject who has cancer, a pre-cancerous condition, disease, age-related weight loss, or age-related sarcopenia; inhibiting the progression of pre-cachexia to cachexia in a subject who has cancer, a pre-cancerous condition, disease, age-related weight loss, or age-related sarcopenia; or treating or preventing undesirable muscle or fat loss in a subject who has cancer, a pre-cancerous condition, disease age-related weight loss, or age-related sarcopenia, the method comprising administering to the subject an effective amount of an agent that is:an ERK1/2 inhibitor selected from the group consisting of SCH772984, ARRY162, AS703026, AZD6244, AZD8330, BIX02188, BIX02189, honokiol, lenalidomide, PD98059, PD184352, PD325901, PD318088, RDEA119, SCH772984, SL-327, TAK733, trametinib (GSK1120212), U0126, and Vx-11e;
wherein, prior to treatment, a protein marker signature is detected in a biological sample obtained from the subject by detecting in the sample an alteration in at least three markers selected from the group consisting of S100A2 or S100A4; S100A8 or S100A9; and S100A7 relative to a reference;
detecting in the sample an alteration in at least four markers selected from the group consisting of: S100A2 or S100A4; S100A8 or S100A9; S100A7 and S100A14 relative to a reference; or
measuring the levels of at least five markers selected from the group consisting of S100A2 or S100A4; S100A8 or S100A9; S100A7; S100A14 and S100P in the sample.
US Pat. No. 10,191,034

DOSAGE REGIMEN FOR ADMINISTRATING A CD19×CD3 BISPECIFIC ANTIBODY TO PATIENTS AT RISK FOR POTENTIAL ADVERSE EFFECTS

AMGEN RESEARCH (MUNICH) G...

1. A method for treating a human patient suffering from malignant CD19-positive lymphoma or leukemia, wherein the patient is at risk for potential adverse effects resulting from treatment with a CD19×CD3 bispecific antibody comprising an amino acid sequence encoded by the nucleic acid sequence set forth in SEQ ID NO: 2 or the amino acid sequence set forth in SEQ ID NO: 1, the method comprising:(a) determining in the peripheral blood of the patient a ratio of B cells to T cells and total B cell count; and
(b) identifying the patient at risk as comprising a ratio of B cells to T cells of about 1:8 or lower;
(i) wherein a total B cell count of less than 40 B cells per microliter of peripheral blood is indicative of a higher risk for potential adverse effects for said patient; and
(ii) wherein a total B cell count of 40 B cells or greater per microliter of peripheral blood is indicative of a lower risk of potential adverse effects for said patient,
(c) administering the CD19×CD3 bispecific antibody
(i) to the patient who is at higher risk in an incremental dosage schedule to reduce the possibility of potential adverse effects in the patient,
wherein a first dose is administered for a first period of time and a second dose is consecutively administered for a second period of time,
wherein said second dose is greater than said first dose, and
wherein said second period of time exceeds said first period of time; or
(ii) to the patient who is at lower risk in a constant dose for at least four weeks.
US Pat. No. 10,189,757

CHROMIA BASED FLUORINATION CATALYST

Mexichem Amanco Holding S...

1. A chromia-based fluorination catalyst consisting of:amorphous chromia;
zinc oxide in a total amount of zinc of from 0.5 to 25% by weight of the catalyst; and
crystalline chromium oxide in a total amount of from 0.1 to 2.5% by weight of the catalyst;
which catalyst is supported or unsupported.
US Pat. No. 10,191,058

DIAGNOSIS OF CANCER BY DETECTING AUTO-ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR (VEGFR)

CELLTREND GMBH, Luckenwa...

1. A method for treating a vascular endothelial growth factor receptor (VEGFR) or vascular endothelial growth factor (VEGF) associated cancer, comprising(i) determining the level of antibodies against VEGFR in a sample from a subject suspected of having such cancer,
(ii) comparing the determined level in the sample to a control level of VEGFR antibodies derived from subjects without cancer;
(iii) identifying a subject having a decreased level of said antibodies in the subject's sample as compared to the level of said antibodies in the control, and
(iv) administering to the subject from step (iii) a drug selected from the group consisting of an angiogenesis inhibitor, an anti-VEGF antibody, and bevacizumab.
US Pat. No. 10,191,062

MODEL GUT SYSTEM

University of Newcastle U...

1. An method for analysing carbohydrates, and/or triglycerides, and/or proteins, and/or lipids, or breakdown products thereof; or for simulating digestion of an edible/potable substance, the method comprising:(a) subjecting the carbohydrate, triglyceride, protein lipid, break down product or edible/potable substance to a salivary phase consisting essentially of synthetic saliva comprising an aqueous mixture of one or more salivary enzyme(s), and one or more suitable salivary diluent components at a pH in the range of from about 5 to 9;
(b) subjecting the product of (a) to a gastric phase consisting essentially of synthetic gastric juice comprising an aqueous mixture of gastric lipase, pepsin and one or more suitable gastric diluent components, at a pH from about 1.5 to about 3.5, wherein the synthetic gastric juice is added to the gastric phase at a rate of 0.1-2.5 ml/min; and
(c) subjecting the product of (b) to a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, and porcine bile, wherein the pancreatic diluent is added to the pancreatic phase at a rate of 0.1 to 2.5 ml/min.
US Pat. No. 10,190,074

COMPOSITION COMPRISING CHOLESTEROL

GOLDEN OMEGA S.A., Las C...

1. A process for producing a composition comprising at least 20% by weight of cholesterol, based on 100% total weight of the composition, the process comprising the steps of:(a) distilling a fish oil having at most 2% by weight of free fatty acids, based on 100% total weight of the fish oil, in an admixture with an auxiliary fluid in a vacuum distillation column to obtain a first distillate and a first residue; and
(b) distilling the first distillate in a vacuum distillation column to obtain a second distillate and a second residue, wherein (i) the second residue comprises the composition comprising at least 20% by weight cholesterol, based on the total weight of the composition, and (ii) the composition has a lower content of anthropogenic contaminants than the fish oil.
US Pat. No. 10,190,091

METHODS OF CELL SEPARATION

CELLS 4 LIFE GROUP LLP, ...

1. A method for separating cells, said method comprising:(a) contacting a blood cell-containing sample containing erythrocyte blood cells with:
(i) a macromolecular erythrocyte sedimentation enhancer, and
(ii) dimethyl sulphoxide (DMSO), dimethylglycine (DMG) and/or valine;
(b) allowing said sample to partition into a sedimented phase and a supernatant phase; and
(c) recovering non-erythrocyte blood cells from said supernatant phase;
wherein in step (a), when the sample is contacted with components (i) and (ii), the resulting mixture comprises component (i) at a concentration of 0.01 to 10% w/v, and component (ii) at a concentration of 0.01 to 10% w/v.
US Pat. No. 10,190,098

AAV VECTORS PRODUCED BY INSECT CELLS COMPRISING REP52 AND REP78 CODING SEQUENCES WITH DIFFERENTIAL CODON BIASES

UniQure IP B.V., Amsterd...

1. A recombinant adeno-associated virus (rAAV) virion obtainable by culturing an insect cell under conditions such that rAAV virions are produced and recovering the rAAV virions, wherein the insect cell comprises a baculoviral vector comprising:(i) a first nucleotide sequence encoding a first amino acid sequence of an AAV Rep52 protein selected from the group consisting of:
(a) a sequence of at least 85% identity with SEQ ID NO: 10;
(b) a nucleotide sequence complementary to the full length sequence of (a); and
(c) a nucleotide sequence that differs from the sequence of (a) due to degeneracy of the genetic code; and
(ii) a second nucleotide sequence encoding a second amino acid sequence of an AAV Rep78 protein;
(iii) a third nucleotide sequence comprising two AAV inverted terminal repeat (ITR) sequences and a nucleotide sequence encoding a gene product of interest located between the two AAV ITR sequences; and,
(iv) a fourth nucleotide sequence comprising AAV capsid protein-coding sequences operably linked to expression control sequences for expression in an insect cell;
wherein the first and the second amino acid sequences share at least 90% sequence identity in a region from the second amino acid residue to the C-terminal residue of the AAV Rep52 protein, and
wherein a portion of the first nucleotide sequence and a portion of the second nucleotide sequence that encode the region from the second amino acid residue to the C-terminal residue of the AAV Rep52 protein each comprise one or more contiguous stretches of at least 300 nucleotides that are less than 90% identical.
US Pat. No. 10,190,106

CAS9-DNA TARGETING UNIT CHIMERAS

Univesity of Massachusett...

1. A fusion protein comprising an attenuated Streptococcus pyogenes Cas9 (SpCas9) nuclease, said nuclease comprising a protospacer adjacent motif recognition domain having a lysine-substituted or serine substituted arginine residue and a DNA binding domain (DBD) protein.
US Pat. No. 10,190,123

ENGINEERING OF MULTI-CARBON SUBSTRATE UTILIZATION PATHWAYS IN METHANOTROPHIC BACTERIA

CALYSTA, INC., Menlo Par...

1. A recombinant methanotrophic bacterium, comprising at least one exogenous nucleic acid encoding a glucose utilization pathway component,wherein glucose is not utilized as a primary carbon source by an unmodified parent methanotrophic bacterium;
wherein the encoded glucose utilization pathway component comprises a glucose transporter selected from the group consisting of phosphoenolpyruvate:glucose phosphotransferase system, a glucose-ion symporter, an ABC transporter, a glucose/galactose transporter (GluP), or a galactose permease (GalP) and is expressed in a sufficient amount to permit growth of the recombinant methanotrophic bacterium on glucose as a primary carbon source; and
wherein the methanotrophic bacterium is selected from Methylococcus capsulatus, Methylornonas sp. 16A, Methylosinus trichosporium, Methylosinus sporium, Methylacystis parvus, Methylomonas methanica, Methylomonas albus, Methylobacter capsulatus, Methylomonas flagellata, Methylacidiphilum infernorum, Methylomicrobium alcaliphilum, Methylocella silvestris, Methylocella palustris, Methylocella tundrae, Methylocystis daltona, Methylocystis bryophila, or Methylocapsa aurea.
US Pat. No. 10,188,593

POLYSACCHARIDE DELIVERY PARTICLE

Spray-Tek, Inc., Middles...

1. A controlled release particle comprising 10-70 wt. % of a hydrophobic active ingredient, 21-72 wt. % of a polysaccharide, 3.80-12 wt. % of a crosslinking agent, 1.00-6 wt. % of a catalyst, 0.10-5 wt. % of a silica flow aid, and optionally 0.10 -5 wt. % of a desiccant, wherein the controlled release particle is anhydrous and the hydrophobic active ingredient is dispersed in a crosslinked polysaccharide matrix effective to retain the hydrophobic active ingredient upon exposure to water and effective to release the hydrophobic active ingredient in response to at least one of friction and enzymes.
US Pat. No. 10,190,131

METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS

BASF Plant Science GmbH, ...

1. A process for producing a transgenic plant producing eicosapentaenoic acid, docosapentaenoic acid and/or docosahexaenoic acid comprising introducing into a plant:a) a nucleic acid sequence encoding a polypeptide having ?6-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 2;
b) a nucleic acid sequence encoding a polypeptide having ?6-elongase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 172;
c) a nucleic acid sequence encoding a polypeptide having ?5-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 52;
d) a nucleic acid sequence encoding a polypeptide having ?5-elongase activity, wherein said nucleic acid sequence is at least 90% identical to SEQ ID NO: 64; and
e) optionally a nucleic acid sequence encoding a polypeptide having ?4-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 78;
wherein the nucleic acid sequence encoding the polypeptide having ?5-elongase activity is modified to adapt to the codon usage in one or more plant species.
US Pat. No. 10,189,875

ANTI-CANCER PEPTIDE AND USE THEREOF

ENSOL BIOSCIENCES INC., ...

1. A peptide consisting of the amino acid sequence of SEQ ID NO: 1 or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,189,876

CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES

Aadigen, LLC, Pacific Pa...

1. A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of X1WX2RLX3X4X5X6X7X8 (SEQ ID No: 5), wherein X1 is beta-A or S; X2, X6, and X7 are, independently from each other, W or F; X5 is S or R, and X8 is R or none, and wherein X3 is R if X5 is S, X3 is S if X5 is R, X4 is L or none if X8 is R, and X4 is L if X8 is none.
US Pat. No. 10,188,596

OMEGA-7 FATTY ACID COMPOSITION, METHODS OF CULTIVATION OF TRIBONEMA FOR PRODUCTION OF COMPOSITION AND APPLICATION OF COMPOSITION

QINGDAO INSTITUTE OF BIOE...

1. A method of cultivation of Tribonema sp., comprising the steps to carry out heterotrophy and/or mixotrophy of Tribonema sp.
US Pat. No. 10,188,598

STERILIZED CHLORHEXIDINE ARTICLE AND METHOD OF STERILIZING A CHLORHEXIDINE ARTICLE

Sage Products, LLC, Cary...

1. A sterilized chlorhexidine product for topical disinfection, said sterilized chlorhexidine product comprising:a package defining an interior volume;
a sterilized chlorhexidine article comprising,
a sterilized applicator for facilitating application; and
a sterilized antiseptic composition impregnated in said sterilized applicator, said sterilized antiseptic composition comprising,
sterilized water in an amount of at least 50 wt. % based on a total weight of said sterilized antiseptic composition, and
sterilized chlorhexidine gluconate dissolved in said sterilized water in an amount of from 1.5 to 5.0 wt. % based on the total weight of said sterilized antiseptic composition;
wherein said sterilized applicator and said sterilized antiseptic composition are disposed in said interior volume of said package, and wherein said sterilized chlorhexidine article has a sterility assurance level of from 10?3 to 10?9.
US Pat. No. 10,189,880

T CELL RECEPTORS DIRECTED AGAINST BOB1 AND USES THEREOF

LEIDEN UNIVERSITY MEDICAL...

1. An isolated nucleic acid molecule comprising a promoter operatively linked to a polynucleotide that encodes a T cell receptor comprising a CDR3 region that specifically binds to Bob1, comprisinga. a first polynucleotide that encodes a TCR? polypeptide comprising a CDR3 region comprising the amino acid sequence of SEQ ID NO: 1, or SEQ ID NO: 25; and
b. a second polynucleotide that encodes a TCR? polypeptide comprising a CDR3 region comprising the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 28,
wherein the CDR3 region of the TCR? polypeptide and TCR ? polypeptide together specifically bind to Bob1.
US Pat. No. 10,188,601

CONTINUOUS LONG-TERM CONTROLLED RELEASE OF TELOMERASE INHIBITORS

Brenda Laster, Meitar (I...

1. A solid implant device suitable for the long-term, controlled release of a telomerase-inhibiting agent comprising Pd-meso-tetra(N-methyl-4-pyridyl)-porphyrin into tumor tissue, wherein said device comprises a homogeneous solid mixture of the Pd-meso-tetra(N-methyl-4-pyridyl)-porphyrin and poly-(lactic-co-glycolic) acid copolymer formulated for a long term controlled release of greater than 19 days of said Pd-meso-tetra(N-methyl-4-pyridyl)-porphyrin, wherein said implant device is in the form of a solid body that is implantable directly into tumor tissue, and wherein the solid mixture has a degree of homogeneity that can be obtained by solidifying a homogeneous solution of the Pd-meso-tetra(N-methyl-4-pyridyl)-porphyrin and the poly-(lactic-co-glycolic) acid copolymer.
US Pat. No. 10,190,142

HIGH-PURITY GALACTOOLIGOSACCHARIDE COMPOSITIONS, PREPARATIONS, AND APPLICATIONS THEREOF

KING-PREBIOTICS BIOTECHNO...

1. A composition, comprising:a carrier; and
a high-purity galactooligosaccharide composition comprising at least 99% w/w of galactotriose, galactotetraose, and galactooligosaccharide with five or more sugar units;
wherein the high-purity galactooligosaccharide composition consists of 48-57% w/w galactotriose, 25-32% w/w galactotetraose, and 15-22% w/w galactooligosaccharide with five or more sugar units, and lower than 1% w/w of monosaccharides and disaccharides.
US Pat. No. 10,190,143

METHOD FOR SYNTHESIZING SELECTIVELY LABELED RNA

THE BOARD OF REGENTS OF T...

1. A method for synthesizing a RNA, comprising performing an initiation stage, an elongation stage, and a termination stage, wherein:(a) the initiation stage comprises:
(i) providing a solid phase comprising a DNA template, wherein the DNA is attached to a solid substrate;
(ii) providing a first liquid phase comprising a RNA polymerase and ribonucleoside triphosphates (rNTPs);
(iii) mixing the solid phase and first liquid phase;
(iv) incubating the solid phase and first liquid phase at 4-37° C. for 5-30 minutes to initiate synthesis of the RNA;
(v) pausing the RNA synthesis by incubating the solid phase and first liquid phase at 0-5° C., whereupon the solid phase comprises the RNA polymerase and the RNA being synthesized; and
(vi) separating the solid phase from the first liquid phase;
(b) the elongation stage comprises:
(i) providing a second liquid phase comprising rNTPs;
(ii) mixing the solid phase and second liquid phase;
(iii) incubating the solid phase and second liquid phase at 4-37° C. for 5-20 minutes to elongate the RNA;
(iv) pausing the RNA synthesis by incubating the solid phase and second liquid phase at 0-5° C. for 5-30 minutes;
(v) separating the solid phase from the second liquid phase; and
(vi) repeating steps (i)-(v) of part (b) n times, wherein n is equal to 1-100, and wherein the rNTPs in the second liquid phase are the same or different in each repeat;
(c) the termination stage comprises:
(i) providing a third liquid phase comprising rNTPs;
(ii) mixing the solid phase with the third liquid phase;
(iii) incubating the solid phase and third liquid phase at 4-37° C. for 5-30 minutes; and
(iv) pausing the RNA synthesis by incubating the solid phase and third liquid phase at 0° C. for 5-30 minutes; wherein steps (a)-(c) are repeated multiple times, and wherein rNTPs of at least one of the first liquid phase, the second liquid phase, or third liquid phase comprise a label.
US Pat. No. 10,189,119

SOLDER ALLOY FOR DIE BONDING

Nihon Handa Co., Ltd., (...

1. A solder alloy for die bonding consisting of bismuth, 0.05% by mass to 3.0% by mass of antimony, 0.01% by mass to 1.0% by mass of germanium and inevitable impurities.
US Pat. No. 10,188,609

MICROPARTICLES COMPRISING A PROBIOTIC, CROSS-LINKABLE REAGENT, A DENATURED PROTEIN, POLYOL PLASTICISER AND TREHALOSE

ProGel Pty Ltd, Brisbane...

1. A microparticle precursor composition comprising a blend of a probiotic, a cross-linkable reagent, a denatured protein, a polyol plasticizer, trehalose and a carrier, wherein the blend does not contain a cross-linking reagent.
US Pat. No. 10,188,611

STABLE LIQUID FILLED HARD CAPSULE COMPRISING BETA-HYDROXY-BETA METHYLBUTYRIC ACID

Capsugel Belguim NV, Bor...

1. A liquid filled hard capsule, comprising:a hard capsule shell comprising hydroxypropyl methyl cellulose; and
a liquid fill inside the hard capsule shell comprising an effective amount of beta-hydroxy-beta-methylbutyric acid (HMB free acid) in liquid form and at least one excipient selected from quaternary ammonium salts, amino acids, amino acid derivatives, fructose, and/or any mixture thereof;wherein the excipient is present from about 30% w/w to about 60% w/w of the liquid fill and the liquid filled hard capsule is physically stable.
US Pat. No. 10,188,099

HIGH DENSITY CELL BANKING METHODS

GENZYME CORPORATION, Bos...

1. A non-centrifugal method for producing a high-density frozen mammalian cell bank, the method comprising:a) culturing mammalian cells in a perfusion bioreactor to a first cell density by continuously removing growth medium from a culture and replacing with fresh growth medium, wherein the bioreactor is coupled to a cell retention system comprising an alternating tangential flow filtration system including a filter;
b) non-centrifugally concentrating the cells cultured in the perfusion bioreactor coupled to the cell retention system, wherein the cells are concentrated to a second cell density greater than the first cell density by removing the growth medium from the culture using the filter and, thereby reducing the volume of the growth medium to produce a concentrated cell population of about 1×108 cells/mL; and
c) cryopreserving the concentrated cell population to produce a high-density frozen mammalian cell bank,
wherein the high-density frozen mammalian cell bank has a post-thaw viability of at least 90%.
US Pat. No. 10,188,612

PHARMACEUTICAL COMPOSITIONS FOR INHALATION

Vectura Limited, Wiltshi...

1. Microparticles for use in a pharmaceutical composition for pulmonary administration, comprising particles of an active substance having on their surfaces particles of a hydrophobic material comprising magnesium stearate to promote the dispersal of the active particles on actuation of an inhaler or to delay the dissolution of the active substance in an aqueous medium, wherein the particles of hydrophobic material are applied to the particles of active substance experiencing a high shear force, wherein the microparticles comprise an effective amount of one or more of the substances selected from the group consisting of antimuscarinic, a ?2-agonist, a steroid, a peptide and a polypeptide, and wherein, upon inhalation of the microparticles, the active substance exerts its pharmacological effect over a period significantly greater than the period over which the active substance exerts its pharmacological effect when inhaled alone.
US Pat. No. 10,188,102

LOW FOAM SURFACTANT COMPOSITION AND METHODS OF MAKING THE SAME

Momentive Performance Mat...

1. A low foam surfactant composition comprisinga) di-trisiloxane alkoxylate component of formula (I):
(R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2  (1)
where R1, R2, R3, R4, R6, R7, R8 and R9 each independently is methyl, ethyl or linear or branched monovalent hydrocarbon radical of 3 or 4 carbon atoms,
R5 is a divalent polyalkyleneoxide group of the structure:
—(R10)aO(C2H4O)b(C3H6O)c(C4H8O)d—(R11)e—
where R10 and R11 each independently is a linear or branched divalent hydrocarbon radical of from 2 to 6 carbon atoms, a and e each independently is 0 or 1, b is 0 or greater, c is 1 or greater, and d is 0 or greater, provided that 1?b+c+d?20; and,
b) mono-trisiloxane alkoxylate component of formula (II):
(R12R13R14SiO)2Si(R15)R16  (11)
where R12, R13, R14 and R15 each independently is a linear or branched monovalent hydrocarbon radical of from 1 to 4 carbon atoms, and
R16 is a monovalent polyalkyleneoxide group of the structure:
—R17O(C2H4O)g(C3H6O)h(C4H8O)i—R18
where —R17 is a linear or branched divalent hydrocarbon radical of from 2 to 6 carbon atoms,
R18 is hydrogen, monovalent hydrocarbon radical of from 1 to 4 carbon atoms or acetyl, and g, h and i each independently is 0 or greater, provided that 1?g+h+i?15;
and, wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate (II).
US Pat. No. 10,189,900

METHOD FOR SCREENING FOR AUTOPHAGY ACTIVATOR OR INHIBITOR

KOREA FOOD RESEARCH INSTI...

1. An isolated antibody that specifically binds to phosphorylated Beclin 1, said antibody binds to the epitope of the amino acid sequence set forth in SEQ ID NO:1, wherein the fifth amino acid residue serine is phosphorylated.
US Pat. No. 10,189,901

METHODS FOR IMPROVING CARDIAC FUNCTION BY ADMINISTERING AN ANTIBODY THAT ACTIVATES APLNR

Regeneron Pharmaceuticals...

1. A method for inducing vasodilation and/or angiogenesis in a subject, the method comprising administering a pharmaceutical composition to a subject in need thereof, wherein the pharmaceutical composition comprises an isolated antibody, antibody-fusion protein or antigen-binding fragment, wherein the antibody, antibody-fusion protein or antigen-binding fragment thereof comprises complementarity determining regions HCDR1-HCDR2-HCDR3-LCDR1-LCDR2-LCDR3 having the amino acid sequences of SEQ ID NOs: 382-383-384-377-385-386, respectively, and wherein the antibody, antibody-fusion protein or antigen-binding fragment thereof activates apelin receptor (APLNR)-mediated inhibition of cAMP accumulation with at least 39% of maximum apelin dose response activation.
US Pat. No. 10,188,876

LOCALLY INJECTABLE DOSIMETRIC ORGAN SPACER

DOSEVUE NV, Mol (BE)

1. A system for measuring a dose of ionizing irradiation received by a pre-determined body part during a radiotherapy treatment, the system comprising:a) a viscous or semi-solid radiation sensitive filler adapted for being injected between said predetermined body part and a tissue to be protected from radiation, wherein the radiation sensitive filler is adapted for undergoing a measurable physical and/or chemical change under the influence of ionizing irradiation and for substantially preserving, during said radiotherapy treatment, its initial morphology in order to minimize dose to the tissue to be protected from radiation, the initial morphology being determined by the shape and volume of said radiation sensitive filler upon injection between said predetermined part of the body and said tissue to be protected;
b) a detector system adapted for measuring said physical and/or chemical change within the radiation sensitive filler by sending an energy wave to the radiation sensitive filler and capturing a signal emitted therefrom; and
c) a control unit adapted for processing said captured signal and calculating a dose of ionizing radiation previously or simultaneously received by each part of the volume of the radiation sensitive filler taking said signal into account.
US Pat. No. 10,188,621

CRYSTALLINE POLYMORPHIC FORMS OF MONOSODIUM N-[-8-(2-HYDROXYBENZOYL)AMINO]CAPRYLATE

EMISPHERE TECHNOLOGIES, I...

1. A method for preparing a pharmaceutical composition comprising a monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate exhibiting an X-ray powder diffraction pattern having a peak at 2.98±0.2° 2? and at least one active agent, wherein the active agent is a peptide, the method comprising(i) wet granulating monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate, in the presence of the at least one active agent and one or more pharmaceutically acceptable excipients, to yield a first mixture comprising a trihydrate of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate,
(ii) drying the first mixture comprising the trihydrate of monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate to obtain a second mixture comprising monosodium N-[8-(2-hydroxybenzoyl)amino]caprylate exhibiting an X-ray powder diffraction pattern having a peak at 2.98±0.2° 2? , and
(iii) directly compressing the second mixture to form the pharmaceutical composition.
US Pat. No. 10,189,905

BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES

S-TARGET THERAPEUTICS GMB...

1. A method for performing active immunotherapy for an allergic disease, comprising the step of administering to a subject therapeutically effective amount of a molecule or molecule complex comprising a TLR9 binding part capable of binding to TLR9, a CD32 binding part capable of binding to CD32, and at least one antigen,wherein the TLR9 binding part is a CpG oligodeoxynucleotide,
wherein the CD32 binding part is selected from the group consisting of an antibody and a CD32-binding antibody fragment, and
wherein the allergic disease in the subject is treated.
US Pat. No. 10,191,186

OPTICAL BONDING THROUGH THE USE OF LOW-SOFTENING POINT OPTICAL GLASS FOR IR OPTICAL APPLICATIONS AND PRODUCTS FORMED

SCHOTT CORPORATION, Elms...

1. An infrared optical combination of two optical elements having infrared transmission bonded together by a bonding glass that has infrared transmission, wherein the bonding glass comprises As and S, wherein S>70 mol % and 0 mol %
US Pat. No. 10,190,163

SINGLE CELL NUCLEIC ACIDS FOR HIGH-THROUGHPUT STUDIES

FLUIDIGM CORPORATION, So...

1. A method of exposing cells from a population to at least two different reagents, wherein each cell is exposed to the reagents individually, or in groups of two of more, the method comprising:(a) distributing cells from the population to a plurality of capture sites in a microfluidic device so that a plurality of capture sites each comprises one or more cells;
(b) providing one or more first reagent(s) to each capture site;
(c) providing one or more second reagent(s) to each capture site, wherein the second reagent(s) is/are different from the first reagent(s) and is/are provided separately from the first reagent(s), and the one or more first reagent(s) and the one or more second reagent(s) are separately provided to each capture site after distributing the cells to the capture sites;
(d) conducting a reaction, whereby the reaction products encode an item of capture site information;
(e) recovering the reaction products; and
(f) analyzing the reaction products, wherein such analysis permits the identification of particular reaction products as having been derived from a single cell or group of cells at a particular capture site.
US Pat. No. 10,188,630

METHODS FOR IDENTIFYING AND USING INHIBITORS OF CASEIN KINASE 1 EPSILON ISOFORM FOR INHIBITING THE GROWTH AND/OR PROLIFERATION OF MYC-DRIVEN TUMOR CELLS

Fred Hutchinson Cancer Re...

1. A method of treating a subject having a tumor comprising tumor cells of neural origin that overexpress Myc, comprising:determining that the tumor comprises tumor cells that overexpress Myc; and
then administering to the subject an amount of a composition comprising a CSNK1? inhibitor effective to inhibit the growth and/or proliferation of the tumor cells.
US Pat. No. 10,194,528

COMPOSITE MATERIAL, HIGH-FREQUENCY CIRCUIT BASEBOARD MADE THEREFROM AND PRODUCTION METHOD THEREOF

GUANGDONG SHENGYI SCI. TE...

1. A prepreg produced by a method, the method comprising the steps of:Step 1) preparing a liquid cement consisting of a mixture of:
a) an emulsion of polytetrafluoroethylene in water,
b) a powdery filler, and
c) an auxiliary agent;
Step 2) forming a composite consisting of the liquid cement and a porous, expanded polytetrafluoroethylene (ePTFE film);
wherein the liquid cement is coated onto a surface of and infused into the pores of the porous, ePTFE film; and
wherein the liquid cement coated onto the surface of the porous ePTFE film has a thickness that is controlled below 20 microns; and
Step 3) baking the composite at 80-300° C. to remove water and the auxiliary agent from the composite to form the prepreg.
US Pat. No. 10,190,171

POLYNUCLEOTIDE PRIMERS FOR DETECTING PIK3CA MUTATIONS

QIAGEN MANCHESTER LIMITED...

1. A method of detecting a mutation in a nucleic acid sample containing at least a fragment of the phosphatidylinositol 3-kinase catalytic subunit A (PIK3CA) gene comprising:a) mixing the nucleic acid sample with
a polynucleotide comprising a sequence corresponding to SEQ ID NO:21 to produce a mixture;
b) amplifying copies of a fragment of a PIK3CA gene in the mixture using thermal cycling nucleic acid amplification to produce amplicons; and
c) detecting hybridization of the polynucleotide to the nucleic acid sample wherein hybridization indicates the presence of the mutation in the PIK3CA gene.