US Pat. No. 10,246,545

BISMUTH-CONTAINING CATALYST FOR POLYURETHANE COMPOSITIONS

SIKA TECHNOLOGY AG, Baar...

1. A bismuth-containing catalyst, obtained by reacting at least one bismuth(III) salt or bismuth(III) complex with at least one 1,3-ketoamide with the formula (I),
where R1 and R2 independently of one another are a hydrogen group, a monovalent saturated or unsaturated hydrocarbon group having 1 to 10 carbon atoms, or together are a bivalent alkylene group having 3 to 6 carbon atoms, and
R3 and R4 independently of one another are a hydrogen group, a monovalent saturated hydrocarbon group, which optionally includes heteroatoms, having 1 to 12 carbon atoms, or together are a bivalent alkylene group, which optionally includes heteroatoms, having 3 to 6 carbon atoms.

US Pat. No. 10,246,544

METHOD FOR PRODUCING AN ABLATIVE RESIN

ARIANEGROUP SAS, Paris (...

18. A method for producing a propulsion nozzle, wherein the nozzle is produced from a phenolic resin obtained by carrying out a production method comprising the following steps:a) reduction of a compound of formula A in order to obtain a hydroxybenzyl alcohol of formula B, formulae A and B being the following:

 wherein:
n1 is an integer between 0 and 4 and when n1 is greater than or equal to 2, the substituents R1 are identical or different,
R1 is chosen from: —OH, —COOH, —CHO, the groups —O-Alk wherein Alk denotes a substituted or unsubstituted alkyl chain of 1 to 4 carbon atoms, saturated or unsaturated, substituted or unsubstituted hydrocarbon-based chains comprising between 1 and 20 carbon atoms, interrupted or not with one or more heteroatoms, and having or not having one or more carbonyl or carboxylic acid functions, substituted or unsubstituted, monocyclic or polycyclic, saturated, unsaturated or aromatic carbocyclic or heterocyclic groups having or not having one or more carbonyl or carboxylic acid functions, and substituted or unsubstituted aryl groups having or not having one or more carbonyl or carboxylic acid functions, and
R2 denotes —H or —OH, and
b) polymerization reaction using the hydroxybenzyl alcohol of formula B obtained during step a) in order to obtain the phenolic resin,
wherein there is, during step b), reaction of the hydroxybenzyl alcohol of formula B with a phenolic compound other than said hydroxybenzyl alcohol,
the phenolic compound which reacts with the hydroxybenzyl alcohol during step b) being chosen from: phenol, pyrocatechol, hydroquinone, phloroglucinol, pyrogallol, guaiacol, syringol, bisphenol A, bis-phenol S, para-hydroxybenzaldehyde, vanillin, syringaldehyde, dehydrodivanillin, vanillyl alcohol, syringyl alcohol, para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, ferulic acid, sinapylic acid, para-hydroxybenzoic acid, vanillic acid, syringic acid, gallic acid, para-coumaric acid, eugenol, isoeugenol, cardanols, cardols, anacardic acids, catechin, umbelliferone, juglone, trans-resveratrol, kaempferol, daidzein, delphinidol, enterodiol, lignins, procyanidins, gallotanins, condensed tannins, and resol and novolac resins.

US Pat. No. 10,246,541

OPHTHALMIC LENS AND METHOD FOR MAKING THE SAME

1. A method for making an ophthalmic lens comprising:mixing poly[bis(methacrylate)phosphazene], hydrophilic monomers, and a photoinitiator to form a mixture, wherein the poly[bis(methacrylate)phosphazene] has a mass percentage of 3.2% to 3.5% of a total mass of the mixture, the hydrophilic monomers have a mass percentage of 96% of the total mass of the mixture, the photoinitiator has a mass percentage of 0.5% to 0.8% of the total mass of the mixture;
feeding the mixture into a mold, and heating or exposing the mixture to ultraviolet radiation, thereby causing the poly[bis(methacrylate)phosphazene] to function as a cross-linking agent which undergoes a polymerization reaction with the hydrophilic monomers and the photoinitiator to form a polyphosphazenes hydrogel; and
separating the polyphosphazenes hydrogel from the mold, thereby the polyphosphazenes hydrogel forming the ophthalmic lens.

US Pat. No. 10,246,540

RAPID AZEOTROPIC PHOTO-COPOLYMERIZATION OF STYRENE AND METHACRYLATE DERIVATIVES AND USES THEREOF

ADA FOUNDATION, Chicago,...

1. A composition of matter, comprising:two or more vinyl-containing monomers consisting of at least two different types of vinyl functional monomers, wherein the two or more vinyl-containing monomers are triethyleneglycol divinylbenzyl ether (TEG-DVBE) and methacrylate derivatives; and
one or more initiators;
wherein the two or more vinyl-containing monomers undergo vinyl conversion to form a composition-controlled cross-linked resin.

US Pat. No. 10,246,536

FUNCTIONALIZED HIGHLY SYNDIOTACTIC POLYSTYRENE AND PREPARATION METHOD THEREOF

Changchun Institute of Ap...

1. A preparation method of a functionalized syndiotactic polystyrene, comprising:performing a polymerization of a functionalized styrene or a polymerization of styrene and a functionalized styrene in the presence of a catalyst to obtain the functionalized syndiotactic polystyrene, wherein the functionalized syndiotactic polystyrene comprises a repeating unit having a structure represented by formula (I), or comprises a repeating unit having a structure represented by formula (I) and a repeating unit having a structure represented formula (II):

wherein the functionalized styrene has a structure represented by formula (III):

wherein in formula (I) and formula (III),
R is independently selected from a C1-20 alkoxy group, a C6-20 aryloxy group, a C1-20 alkylthio group, a C6-20 arylthio group, or a C6-20 aryl group;
m is the number of substituent R and is independently selected from an integer from 1 to 5; and
the catalyst comprises a rare earth complex, an organoboron compound, and an organoaluminum compound.

US Pat. No. 10,246,531

PRODUCTION METHOD FOR OLEFIN-BASED POLYMER, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN-BASED POLYMER

IDEMITSU KOSAN CO., LTD.,...

1. A production method for polypropylene, the production method comprising polymerizing propylene in the presence of the following components (A) to (D):(A) a transition metal compound;
(B) a boron compound capable of forming an ion pair with the component (A);
(C) an organoaluminum compound; and
(D) water,
wherein:
a molar ratio [(D)/(A)] of a molar quantity of the component (D) to a molar quantity of a transition metal in the component (A) is 5 or more and 10,000 or less;
a molar ratio [(D)/(C)] of the molar quantity of the component (D) to a molar quantity of an aluminum atom in the component C) is more than 0 and 0.9 or less;
the transition metal compound (A) is a double crosslinked metallocene complex represented by a formula (I):

M represents a metal element of Groups 3 to 10 of the periodic table or the lanthanoid series;
E1 and E2 each represent a ligand selected from a substituted cyclopentadienyl group, an indenyl group, a substituted indenyl group, a heterocyclopentadienyl group, a substituted heterocyclopentadienyl group, an amide group, a phosphide group, a hydrocarbon group, and a silicon-containing group, form a crosslinked structure via A1 and A2, and may be identical to or different from each other;
X represents a ?-bonding ligand, and when a plurality of X's are present, the plurality of X's may be identical to or different from each other, and X may be crosslinked with any other X, E1, E2, or Y;
Y represents a Lewis base, and when a plurality of Y's are present, the plurality of Y's may be identical to or different from each other, and Y may be crosslinked with any other Y, E1, E2, or X;
A1 and A2 each represent a divalent crosslinking group for bonding two ligands, and each represent a hydrocarbon group having 1 to 20 carbon atoms, a halogen-containing hydrocarbon group having 1 to 20 carbon atoms, a silicon-containing group, a germanium-containing group, a tin-containing group, —O—, —CO—, —S—, —SO2—, —Se—, —NR1—, —PR1—, —P(O)R1—, —BR1—, or —AlR1—, wherein R1 represents a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 20 carbon atoms, or a halogen-containing hydrocarbon group having 1 to 20 carbon atoms, and may be identical to or different from each other;
q represents an integer of from 1 to 5 representing [(valence of M)-2]; and
r represents an integer of from 0 to 3.

US Pat. No. 10,246,529

PROCATALYST FOR POLYMERIZATION OF OLEFINS

SABIC GLOBAL TECHNOLOGIES...

1. A process for preparing a procatalyst for preparing a catalyst composition for olefin polymerization, said process comprising the steps of:ia) contacting a Grignard reagent comprising R4zMgX42-z and an alkyl magnesium compound MgR4?2 with an alkoxy- or aryloxy-containing silane compound to give a first intermediate reaction product, being a solid Mg(OR1)xX12-x, wherein:
R4 and R4? are the same as R1 being a linear, branched or cyclic hydrocarbyl group independently selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, alkoxycarbonyl, alkylaryl groups, and one or more combinations thereof; wherein said hydrocarbyl group is substituted or unsubstituted, and optionally contains one or more heteroatoms;
X4 and X1 are each independently selected from the group consisting of fluoride (F—), chloride (Cl—), bromide (Br—) or iodide (I—);
x is in a range of larger than 0 and smaller than 2, being 0 z is in a range of larger than 0 and smaller than 2, being 0 ib) precipitating the solid Mg(OR1)xX12-x obtained in step ia) by contacting it with an tetrahalogensilane, SiX4?4, wherein X4? is each independently selected from the group consisting of fluoride (F—), chloride (Cl—), bromide (Br—) or iodide (I—), to obtain a solid support;
ii) optionally contacting the solid support obtained in step ib) with at least one activating compound selected from the group consisting of activating electron donors and metal alkoxide compounds of formula M1(OR2)v-w(OR3)w and M2(OR2)v-w(R3)w, to obtain a second intermediate reaction product; wherein:
M1 is a metal selected from the group consisting of Ti, Zr, Hf, Al or Si;
M2 is a metal being Si;
v is the valency of M1 or M2;
w is smaller than v;
R2 and R3 are each a linear, branched or cyclic hydrocarbyl group independently selected from the group consisting of alkyl, alkenyl, aryl, aralkyl, alkoxycarbonyl, alkylaryl groups, and one or more combinations thereof; wherein said hydrocarbyl group is substituted or unsubstituted, and optionally contains one or more heteroatoms;
iii) contacting the first or second intermediate reaction product obtained in step ib) or ii) respectively, with a halogen-containing titanium compound and either an activator or an internal electron donor to obtain a third intermediate reaction product;
iv) optionally modifying the third intermediate reaction product obtained in step iii) with a modifier having the formula MX3, wherein M is a metal selected from the Group 13 metals and transition metals of the IUPAC periodic table of elements, and wherein X is a halide, to yield a modified intermediate reaction product; and
v) contacting said third intermediate reaction product obtained in step iii) or said modified intermediate reaction product obtained in step iv) with a halogen-containing titanium compound and in the case that in step iii) an activator was used an internal donor to obtain the procatalyst.

US Pat. No. 10,246,491

PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA

AILERON THERAPEUTICS, INC...

1. A peptidomimetic macrocycle having the formulaor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,486

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

Gilead Sciences, Inc., F...

1. A compound of Formula I:or a pharmaceutically acceptable salt, isotope, stereoisomer, mixture of stereoisomers, tautomer, ester or prodrug thereof, wherein:A1 is (C2-C5)alkylene, (C2-C5)alkenylene, (C2-C5)alkynylene, —O—(C2-C4)alkylene, —O—(C2-C4)alkenylene, arylene, aryl(C1-C2)alkylene, heterocycloalkylene, pyrazolylene, pyridylene, pyrimidinylene or heterocycloalkyl(C1-C2)alkylene, wherein a sp3 carbon atom of A1 is optionally substituted with one or more (C1-C4)alkyl;
A2 is arylene or heteroarylene, wherein A2 is optionally substituted with halo;
X1 is —O—, —NH— or —N((C1-C4)alkyl)-;
R1a and R1b are independently H, (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl;
R2 is H, (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl;
R3a and R3b are independently H or (C1-C8)alkyl;
R4a and R4b are independently H, —OH, (C1-C4)alkoxy, halo(C1-C4)alkoxy or (C1-C8)alkyl;
R5 is H, (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl, or
R5 forms a cyclic moiety along with —N((C1-C4)alkyl)- of X1 or arylene of A2; and
R6 is H or (C1-C4)alkyl.

US Pat. No. 10,246,483

BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF

ENANTA PHARMACEUTICALS, I...

1. A compound represented by Formula I:
or a pharmaceutically acceptable salt, solvate or ester thereof,
wherein:
R1 is selected from the group consisting of:
1) Hydrogen;
2) Substituted or unsubstituted —C1-C8 alkyl;
3) Substituted or unsubstituted —C2-C8 alkenyl;
4) Substituted or unsubstituted —C2-C8 alkynyl;
5) Substituted or unsubstituted —C3-C8 cycloalkyl;
6) Substituted or unsubstituted aryl;
7) Substituted or unsubstituted arylalkyl;
8) Substituted or unsubstituted heterocycloalkyl;
9) Substituted or unsubstituted heteroaryl; and
10) Substituted or unsubstituted heteroarylalkyl;
Ra, Rb, and Rc are each independently selected from R1; or Ra and Rb, or Ra and Rc, or Rb and Rc are taken together with the two nitrogen atoms to which they are attached and the intervening carbon atom to form a heterocyclic, heteroaryl or heterocycloalkenyl ring;
R2 is selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) Substituted or unsubstituted —C1-C8 alkyl;
4) Substituted or unsubstituted —C2-C8 alkenyl;
5) Substituted or unsubstituted —C2-C8 alkynyl;
6) Substituted or unsubstituted arylalkyl; and
7) Substituted or unsubstituted aryl;
m is 0, 1, 2 or 3;
R3 is hydrogen, hydroxyl, —OSO3H, —OSO3?, —OAc, —PPO3H2 or —OPO32?;
R4 is hydrogen, halogen, CN, N3, hydroxyl, —OSO3H, —OSO3?, —OAc, —OPO3H2, —OPO32?, —SR2 or —NHR2, or R3 and R4 are taken together with the carbons to which they are attached to form —CH?CH—, a cycloalkyl ring or a heterocycloalkyl ring;
R5 and R6 are each independently hydrogen or hydroxyl protecting group; and
R7 is ethyl.

US Pat. No. 10,246,481

BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE

CITY OF HOPE, Duarte, CA...

1. A method of synthesizing a compound having the following structure,
the method comprising,
(i) contacting a compound of formula (II)

 wherein R11 is R11A or R11B, with an oxidizing reagent to provide a compound of formula (III-A) or (III-B),

 or

(ii) when the product of step (i) has a structure according to formula (III-A), contacting the compound of formula (III-A) with an alcohol protecting agent to provide a compound of formula (III-B);
(iii) contacting a compound of formula (III-B) with an alkylating agent in the presence of a sterically hindered base to provide a compound of formula (IV),

(iv) optionally contacting the compound of formula (IV) with an alcohol deprotecting agent to provide a compound of formula (IV-A),

(v) treatment of the compound of formula (IV) or (IV-A) with a reducing agent to provide a compound of formula (I) or (I-A),

 or

 and
(vi) when the product of step (v) has a structure according to formula (I-A), contacting the compound of formula with an alcohol deprotecting agent to provide a compound of formula (I-A);
wherein,
L1 is —C(O)—, —C(O)O—, —C(O)NH—, or —CH2—;
R1 is hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —CHO, —OR1A, —NHR1A, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or a carboxylate protecting group;
R2 is hydrogen or unsubstituted alkyl;
R3 is hydrogen, unsubstituted alkyl, or —OR3A;
R4 is hydrogen, unsubstituted alkyl, or —OR4A;
R5 is hydrogen, unsubstituted alkyl, or —OR5A;
R6 is hydrogen, unsubstituted alkyl, or —OR6A;
R7 is hydrogen, unsubstituted alkyl, or —OR7A;
R8 is hydrogen, unsubstituted alkyl, or —OR8A;
R9 is hydrogen, unsubstituted alkyl, or —OR9A;
R10 is hydrogen, unsubstituted alkyl, or —OR10A;
R11A is hydrogen;
R11B is an alcohol protecting group;
R12 is hydrogen, unsubstituted alkyl, or —OR12A;
R13 is unsubstituted alkyl;
R1A, R3A, R4A, R5A, R6A, R7A, R8A, R9A, R10A, R12A and R13A are independently hydrogen, unsubstituted alkyl, or an alcohol protecting group.

US Pat. No. 10,246,479

METHOD OF PREPARATION OF NANOPORE AND USES THEREOF

THE TRUSTEES OF COLUMBIA ...

1. A tagged nucleotide, wherein the nucleotide comprises a tag capable of being cleaved in a nucleotide polymerization event and detected with the aid of a nanopore, wherein the tagged nucleotide has the structure:
wherein the tag comprises an oligonucleotide which comprises nucleotides having natural bases and (i) at least one abasic site or (ii) at least one nucleotide having a modified base;
wherein R1 is OH, wherein R2 is H or OH, wherein X is a linker and may comprise O, NH, S, or CH2, wherein Z is O, S, or BH3, wherein the base is adenine, guanine, cytosine, thymine, uracil, or a derivative of one of these bases, wherein n is 1, 2, 3, or 4.

US Pat. No. 10,246,474

PREPARATION OF A HYDROXYALKYL PHOSPHONIC ACID

Rohm and Haas Company, P...

1. A process for converting a phosphonate to a hydroxyalkyl phosphonic acid comprising the step of contacting together water, the phosphonate, and a heterogeneous catalyst; wherein the heterogeneous catalyst is a sulfonated crosslinked macroreticular ion exchange resin; wherein the phosphonate is contacted with the sulfonated crosslinked ion-exchange resin at a temperature of from 80° C. to 120° C. for 1 to 24 hours to convert at least 70% of the phosphonate to the hydroxyalkyl phosphonic acid; wherein the phosphonate is characterized by the following formula:
where R is H or acetyl; and R1 is C1-C10-alkyl; and n is 2 to 10; and wherein methyl acetate and methanol are formed in addition to the hydroxyalkyl phosphonic acid.

US Pat. No. 10,246,472

GUANIDINE-FUNCTIONALIZED PARTICLES AND METHODS OF MAKING AND USING

3M Innovative Properties ...

1. A method of making a guanidine-functionalized particle, comprising:reacting O-methylisourea hemisulfate with a linker molecule comprising the formula
(RO)nRa3-nSi—Sm—X
where RO is an alkoxy group comprising one or two carbons, or is an acetoxy group,
where n is 1, 2 or 3,
where Ra is an unreactive group,
where S is a spacer group comprising a backbone with m atoms,
m is from 2-16, inclusive, and
where X is a primary amine that is capable of reacting with the O-methylisourea to form a guanidine group;
and,
reacting at least one of the RO groups of the linker molecule with a hydroxyl group of the particle to form a covalent bond between the linker molecule and the particle.

US Pat. No. 10,246,469

BIARYL KINASE INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of formula (I)or a pharmaceutically acceptable salt thereof, wherein:A is selected from
wherein “” denotes the point of attachment to B;B is selected from
wherein “*” indicates the point of attachment to R5 and “**” indicates the point of attachment to ring A;R1 is selected from hydrogen, amino, —CO2H, cyclopropyl, difluoromethyl, ethyl, halo, hydroxymethyl, methoxy, methoxymethyl, methyl, —NHC(O)CH3, —NHCO2CH3, trifluoromethoxy, trifluoromethyl,
wherein Ra is selected from hydrogen, halo and methyl;R2 is selected from hydrogen, cyano, —CH2OH, halo, and methyl;
R3 is selected from hydrogen, cyano, cyclopropyl, difluoromethyl, fluoromethyl, halo, hydroxymethyl, methoxy, methyl, methylsulfonyl, trifluoromethoxy, trifluoromethyl, —CH2N(CH3)2, and a five-membered aromatic ring containing one, two, or three heteroatoms selected from nitrogen, oxygen, and sulfur;
R4 is selected from hydrogen, halo, and methyl;
R5 is selected from

R6 is selected from hydrogen, ethyl, fluoromethyl, difluoromethyl, methyl, and trifluoromethyl;provided that when A isthen B isR1 is selected fromcyclopropyl, methoxymethyl,R5 is selected from

US Pat. No. 10,246,468

BACE1 INHIBITORS

Hoffmann-La Roche Inc., ...

1. A compound of formula I,
wherein
n is 1, 2 or 3;
R1 is selected from the group consisting of
i) C1-6-alkyl and
ii) halogen-C1-6-alkyl;
R2 is selected from the group consisting of
i) C1-6-alkyl, and
ii) halogen-C1-6-alkyl;
or R1 and R2 form together with the C-atom they are attached to, a C3-6-cycloalkyl-, wherein the C3-6-cycloalkyl- is optionally substituted by one or more substituents selected from the group consisting of halogen and hydroxyl;
R3 is each independently selected from the group consisting of
i) hydrogen,
ii) C1-6-alkyl, and
iii) halogen;
R4 is each independently selected from the group consisting of
i) hydrogen,
ii) C1-4-alkyl, and
iii) halogen;
or wherein R3 and R4 together are —(CH2)m—, wherein m is 2, 3, 4 or 5,
R5 is hydrogen;
R6 is selected from the group consisting of
i) C1-6-alkyl, and
ii) halogen-C1-6-alkyl;
R7 is selected from the group consisting of
i) hydrogen, and
ii) halogen;
R8 is selected from the group consisting of
i) aryl,
ii) aryl substituted by 1-4 substituents individually selected from amino, cyano, halogen, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl, C1-6-alkyl, COOR9, wherein R9 is H or C1-6-alkyl, CONR10R11, wherein R10 is H or C1-6-alkyl C3-6-cycloalkyl and R11 is H or C1-6-alkyl, C3-6-cycloalkyl that is optionally substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy, C3-6-cycloalkyl-C1-6-alkoxy and C3-4-cycloalkyl-C1-6-alkoxy, wherein the cycloalkyl unit is substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy;
iii) heteroaryl, and
iv) heteroaryl substituted by 1-4 substituents individually selected from amino, cyano, halogen, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl, C1-6-alkyl, COOR9, wherein R9 is H or C1-6-alkyl, CONR10R11, wherein R10 is H or C1-6-alkyl C3-6-cycloalkyl and R11 is H or C1-6-alkyl, C3-6-cycloalkyl that is optionally substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy, C3-6-cycloalkyl-C1-6-alkoxy and C3-6-cycloalkyl-C1-6-alkoxy, wherein the cycloalkyl unit is substituted by 1 to 4 substituents individually selected from the group consisting of halogen, cyano, C1-6-alkyl and C1-6-alkoxy;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,464

THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

THE REGENTS OF THE UNIVER...

1. A compound represented by the structure of Formula (4):or a salt thereof, wherein:R1, R2, R4, R5, R8, and Ra are independently selected from hydrogen, halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, or two substituents on the same carbon atom of an C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl come together to form a C3-10 carbocycle or 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle; wherein any C3-10 carbocycle and 3- to 10-membered heterocycle of R1, R2, R4, R5, R8, and Ra is independently optionally substituted with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
R3 is selected from selected from hydrogen, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —S(O)2R20, —S(O)2N(R20)2, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, or two substituents on the same carbon atom of an C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl come together to form a C3-10 carbocycle or 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle; wherein any C3-10 carbocycle and 3- to 10-membered heterocycle of R3 is independently optionally substituted with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
R6 is independently selected at each occurrence from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle, or two substituents on the same carbon atom of an C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl come together to form a C3-10 carbocycle or 3- to 10-membered heterocycle; and C3-10o carbocycle and 3- to 10-membered heterocycle; wherein any C3-10 carbocycle and 3- to 10-membered heterocycle of R6 is independently optionally substituted with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)22, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
R20 at each occurrence is independently selected from hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR30, —SR30, —N(R30)2, —N(R30)C(O)R30, —C(O)R30, —C(O)OR30, —C(O)N(R30)2, —OC(O)R30, —S(O)2R30, —S(O)2N(R30)2, —N(R30)S(O)2R30, —NO2, —P(O)(OR30)2, —P(O)(R30)2, —OP(O)(OR30)2, and —CN; and 3- to 10-membered heterocycle and C3-10 carbocycle;
R30 at each occurrence is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl;
Y is N or C(Ra);
L is absent or selected from alkylene and heteroalkylene;
s is selected from 0, 1, 2, 3, and 4;
R7a is -G-V-R9a:
G is selected from alkylene, heteroalkylene, C3-12 carbocycle, 3- to 12-membered heterocycle, and combinations thereof, wherein G is optionally substituted with one or more R32 groups;
V is selected from a C3-12 carbocycle, and 3- to 12-membered heterocycle;wherein V is optionally substituted with one or more R32 groups;R9a is selected from halogen, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)OR20, —OC(O)R20, —N(R20)S(O)2R20, —NO2, =S, =N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; C3-10 carbocycle and 3- to 10-membered heterocycle; or two R32 on the same carbon atom can come together to form a C3-10 carbocycle or 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle of R32 is independently optionally substituted with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl; and
R32 at each occurrence is selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; C3-10 carbocycle and 3- to 10-membered heterocycle; or two R32 on the same carbon atom can come together to form a C3-10 carbocycle or 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle of R32 is independently optionally substituted with one or more substituents selected from halogen, —OR20, —SR20, —N(R20)2, —N(R20)C(O)R20, —C(O)R20, —C(O)OR20, —C(O)N(R20)2, —OC(O)R20, —S(O)2R20, —S(O)2N(R20)2, —N(R20)S(O)2R20, —NO2, ?O, ?S, ?N(R20), —P(O)(OR20)2, —P(O)(R20)2, —OP(O)(OR20)2, —CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl.

US Pat. No. 10,246,463

HYPOXIA-INDUCIBLE FACTOR 1 (HIF-1) INHIBITORS

The United States of Amer...

9. A pharmaceutical composition comprising:(i) at least one compound or pharmaceutically acceptable salt thereof, the compound having a chemical structure according to Formula I or a pharmaceutically acceptable salt thereof
wherein each bond depicted as “” is a single or double bond as needed to satisfy valence requirements,R1 is —ORa, aryl, heteroaryl, halo, aliphatic, heteroaliphatic, alicyclic, heteroalicyclic, —SRa, —COORa, or —N(Ra)2, and R2 is —ORa, —SRa, alicyclic, heteroalicyclic, aryl, or heteroaryl; or R1 and R2 together are ?O or ?S,
each R3 independently is aryl, heteroaryl, aliphatic, heteroaliphatic, —COORa, or —C(O)N(Ra)2,
m is 0, 1, or 2,
R4 and R5 together with the carbon atoms to which they are bound define a ring B where the ring B is aryl, heteroaryl, alicyclic, or heteroalicyclic, or R4 and R5 independently are hydrogen, aliphatic, heteroaliphatic, halo, —ORa, —SRa, oxygen, or sulfur, and
each Ra independently is hydrogen or alkyl; and
(ii) at least one pharmaceutically acceptable carrier.

US Pat. No. 10,246,460

SYNTHESIS OF TRANS-8-CHLORO-5-METHYL-1-[4-(PYRIDIN-2-YLOXY)-CYCLOHEXYL]-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENE AND CRYTALLINE FORMS THEREOF

Hoffmann-La Roche Inc., ...

1. A process to synthesize compound formula I, comprising reacting compound formula III with compound formula VI

US Pat. No. 10,246,454

SUBSTITUTED 3,4-DIHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-1,6-DIONES AS GAMMA SECRETASE MODULATORS

JANSSEN PHARMACEUTICA NV,...

8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of a compound according to claim 1.

US Pat. No. 10,246,453

BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

Xenon Pharmaceuticals Inc...

1. A compound of formula (I):
wherein:
n is 1, 2, or 3;
m is 1, 2, 3 or 4;
X is a direct bond or —C(R9)R10—;
Y is a direct bond or —C(R11)R12—;
R1 is hydrogen, alkyl, —R17—OR14, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted N-heterocyclyl, an optionally substituted N-heteroaryl, an optionally substituted O-heteroaryl or an optionally substituted S-heteroaryl;
R2 is an optionally substituted 5-membered N-heteroaryl or an optionally substituted 6-membered N-heteroaryl;
R3 is —O — or —N(R13)—;
R4 and R5 are each independently hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
or R4 and R1, together with the carbon to which they are attached, form an optionally substituted cycloalkyl, an optionally substituted heterocyclyl or an optionally substituted aryl, and R5, if present, is hydrogen, alkyl, haloalkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
each R6 is independently hydrogen, alkyl, alkenyl, halo, haloalkyl, cyano, —OR14 or optionally substituted cycloalkyl;
R7 is halo, haloalkyl, cyano or —OR14;
each R8 is independently hydrogen, alkyl, halo, haloalkyl or —OR14;
or two R8's, together with the carbon to which they are both attached, may form an optionally substituted cycloalkyl;
R9,R10, and R12 are each independently hydrogen, alkyl, haloalkyl or —OR14;
or R9 and R11 form an optionally substituted alkylene chain and R10 and R12 are as defined above; and
R13 is hydrogen, alkyl or haloalkyl;
each R14 are each independently hydrogen, alky, haloalkyl, optionally substituted aryl or optionally substituted aralkyl; and
R17 is a direct bond or an optionally substituted alkylene chain;
as an individual stereoisomer, enantiomer or tautomer thereof or a mixture thereof;
or a pharmaceutically acceptable salt, solvate or prodrug thereof;
provided that when R3 is —O—, R2 is not optionally substituted thiadiazolyl.

US Pat. No. 10,246,449

1,2,3 TRIAZOLE-THIAZOLE COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF

1. A 1,2,3 triazole-thiazole compound of formula (I);
wherein;
R is independently selected from the group consisting of alkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl and alkoxyalkyl;
n is 1, 2 or 3; and
X is a halogen;
or pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,448

4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS

1. A compound of formula (I):
whereinR1 is an unsubstituted or substituted 5, 6 or 7-membered, aliphatic or aromatic heterocycle group having 1, 2, 3 or 4 heteroatoms selected from the group consisting of N, O and S; andR2 is selected from the group consisting of hydrogen, C1-C2 alkyl, F, Cl and OH;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,445

METHOD FOR PRODUCING BENZOXAZOLE COMPOUND

SUMITOMO CHEMICAL COMPANY...

1. A method for preparing a compound represented by formula (3):
wherein n is 1, 2, 3, or 4,
which comprises mixing a compound represented by formula (2)

tri(C1-C3 alkyl)silyl(C1-C4 perfluoroalkane), and a fluoride.

US Pat. No. 10,246,444

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

SABILA BIOSCIENCES LLC, ...

1. A compound having formula (I):
including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, wherein:
A is selected from the group consisting of
with the proviso that when A isthen Y cannot be N and X2 cannot be H when Y is N;Z1 is selected from the group consisting of S, SO, and SO2;
Z2 is selected from the group consisting of S, SO, and SO2;
Z3 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
Z4 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
n=0, 1, 2, 3, 4;
W is selected from the group consisting of CO and SO2;
X1 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and, optionally substituted C1-6 alkoxy;
X2 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, OR3,
and the C2-6 sugar alcohols such as ethylene glycol, glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, galacitol frucitol, iditol, inositol, and sorbitol;Y is selected from the group consisting of N and C—CN;
R is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, halogen, C1-6 haloalkyl, C3-7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, alkoxyheteroarylalkyl,

R1a is at each occurrence independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, and C1-6 alkoxy;
R1 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
R2 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
R3 is an optionally substituted C1-6 alkyl;
R4 is at each occurrence independently selected from the group consisting of hydrogen, OH, and OR5;
q=0, 1, 2, 3, 4, or 5;
R5 is at each occurrence an optionally substituted C1-6 alkyl;
two R5 substituents can be joined together with the atoms to which they are bound to form a 5 to 6 membered ring.

US Pat. No. 10,246,442

4-AMINOQUINAZOLIN COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS

JANSSEN PHARMACEUTICA NV,...

1. A compound of the formula (I):wherein:n is 1 or 2;
each R1 is a member independently selected from the group consisting of bromo, fluoro, cyclohexyl, cyclohexyloxy, phenyl, 2-methylphenyl, benzyl, phenoxy, 4-chlorophenoxy, 2,6-dimethyl-phenoxy, piperidinyl, and (2,6-dimethylbenzyl)amino;
R2 is a member selected from the group consisting of —H, cyclopropyl, 2,6-dimethylbenzyl, and —C1-4alkyl;
R3 is a member selected from the group consisting of —H, —C1-4alkyl optionally substituted with —OCH3 or —N(C1-4alkyl)2, cyano, —SO2CH3, tetrahydropyran, —(CH2)mC3-8cycloalkyl, and —(CH2)mphenyl optionally substituted with one or more halo; or —C1-4alkyl; wherein
m is 0-1; or
R2 and R3 can be taken together with the nitrogen to which they are attached to form a pyrrolidine, piperidine, 4-methyl-1,4-diazepane, thiomorpholine, 4-hydroxypiperidine, morpholine, 4-acetamidopiperidine, 4-cyanopiperidine, 4-fluoropiperidine, azepane, or 4-isopropylpiperidine;
or an enantiomer, diastereomer, racemate, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,246,440

INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR ? (T))

1. A method of treating acne, atopic dermatitis and/or psoriasis comprising administering a pharmaceutical composition comprising at least one compound of formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof and/or a solvate thereof:
wherein in formula (I):
L represents a single bond or a methylene group CH2,
X represents a cyclic radical chosen from the radicals X1 and X2 below:

one or two of the elements Y1, Y2, Y3, Y4 and Y5 represent(s) a nitrogen atom and the other elements correspond to a group —CR2, or each of the elements Y1, Y2, Y3, Y4 and Y5 corresponds to a group —CR2,
each of the elements Q1, Q2 and Q3 corresponds to an identical or different —CR2a group,
R1 represents a linear or branched C3-C5 alkyl radical, optionally substituted with a hydroxyl group and/or a halogen atom, a C3-C5 cycloalkyl radical, a linear or branched C2-C5 alkenyl radical, a —CH2—(C3-C5)cycloalkyl radical, a C4-C5 heterocycloalkyl radical, a —CH2—(C4-C5)heterocycloalkyl radical,
R2 represents a hydrogen atom or a halogen atom, a linear or branched C1-C5 alkyl radical, a linear or branched C2-C4 alkenyl radical, a C1-C4 alkoxy radical, a cyano group —CN, a radical —C(?O)R?2 with R?2 denoting a C1-C3 alkoxy radical, a —CF3 radical; said alkyl, alkenyl and alkoxy radicals optionally being substituted with one or more halogen atoms,
R2a represents a hydrogen atom or a halogen atom, a linear or branched C1-C5 alkyl radical, a linear or branched C2-C4 alkenyl radical, a C1-C4 alkoxy radical, a —CN group, a hydroxyl group —OH, a group —CH(R3a)OH, a carboxylic group —COOH, a carbamoyl group —CONR2cR2d, an amido group —NR2cCOR2d, a group —SO2R2c, a group —SOR2c, a group —S(?O)(?NH—R2c), said alkyl, alkenyl and alkoxy radicals optionally being substituted with one or more halogen atoms,
R2c and R2d, which are identical or different, represent a hydrogen atom or a linear or branched C1-C5 alkyl radical;
R3a represents a hydrogen atom or a linear or branched C1-C5 alkyl radical,
R3 represents a hydrogen atom, a halogen atom, a group (CHR6)n—(Z)o—(CHR?6)p—R7 or a group CH?R7,
n, o and p, which are identical or different, represent zero or a natural integer ranging from 1 to 3,
Z represents a divalent group selected from the group consisting of a methylene group —CH2—, an amino group —NH— and an oxygen atom —O—,
R6 and R?6, which are identical or different, represent a hydrogen atom, a methyl group —CH3, a group —OH, a hydroxymethyl group, or a carboxylic function-COOH,
R7 represents:
a hydrogen or a halogen atom,
a group COOR?7 with R?7 denoting (C1)alkyl(C6)heterocycle,
a heterocycloalkyl radical, wherein the heterocycloalkyl radical is optionally substituted with one or more halogen atoms, one or more linear or branched C1-C3 alkyl groups, one or more —OH groups, one or more carbonyl functions, one or more linear or branched C1-C4 hydroxyalkyl groups, one or more amino groups, one or more groups —C(?O)R7a, one or more groups S(?O)2R7a; R7a representing a linear or branched C1-C3 alkyl radical, a linear or branched C1-C3 alkoxy radical, or an amino radical N(R8a)(R8b),
a C3-C6 cycloalkyl radical, wherein the cycloalkyl radical is optionally substituted with one or more methyl radicals, one or more halogen atoms, a cyano group —CN or one or more groups —COR13; R13 denoting a linear or branched C1-C3 alkoxy radical, or a hydroxyl group,
an aromatic radical, wherein the aromatic radical is optionally substituted with one or more halogen atoms, one or more linear or branched C1-C3 alkyl groups optionally substituted with one or more halogen atoms, one or more C1-C3 alkoxy groups, one or more amino groups —NR11R12, one or more groups —COR11, one or more groups —COOR11, one or more amido groups —CONR11R12, one or more groups —SOR11, one or more groups —SO2R11, one or more groups —NHCOR11, one or more groups —NHCOOR11, one or more groups —SO2NR11R12 or one or more —CN groups; R11 and R12, which are identical or different, representing a hydrogen atom, a hydroxyl radical —OH, a linear or branched C1-C3 alkyl radical optionally substituted with one or more halogen atoms;
a heteroaromatic radical, wherein the heteroaromatic radical is optionally substituted with one or more halogen atoms, one or more linear or branched C1-C3 alkyl groups optionally substituted with one or more halogen atoms, one or more C1-C3 alkoxy groups, one or more amino groups —NR11R12, one or more groups —COR11, one or more groups —COOR11, one or more amido groups —CONR11R12, one or more groups —SOR11, one or more groups —SO2R11, one or more groups —NHCOR11, one or more groups —NHCOOR11, one or more groups —SO2NR11R12 or one or more —CN groups; R11 and R12, which are identical or different, representing a hydrogen atom, a hydroxyl radical —OH, a linear or branched C1-C3 alkyl radical optionally substituted with one or more halogen atoms;
R5 represents a hydrogen atom or a halogen atom, a linear or branched C1-C3 alkyl radical optionally substituted with one or more halogen atoms; an amino radical —NH2, a C4-C5 heterocyclic radical, an OCH2—(C4-C5) heterocyclic radical, a radical CH2R?7a with R?7a denoting a methoxy radical, a hydroxyl group —OH, a —CH2COOH group, a group —CH(R5b)OH, a carboxylic group —COOH, a —CN group, a thioxo function,
R5b represents a hydrogen atom, a linear or branched C1-C3 alkyl radical optionally substituted with one or more carboxylic functions; a cyclopropyl radical,
R8a and R8b, which are identical or different, denote a hydrogen atom, a linear or branched C1-C3 alkyl radical or a cyclopropyl radical; and
wherein the compound of formula (I) inhibit activity of a ROR?t receptor.

US Pat. No. 10,246,439

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

ENANTA PHARMACEUTICALS, I...

1. A compound represented by Formula I, or a pharmaceutically acceptable salt thereof:wherein;X1 and X2 are independently C(R8) or N;
X3 is C(R9) or N, in which R9 is selected from the group consisting of hydrogen, optionally substituted —C1-C8 alkyl, optionally substituted —C1-C8 alkoxy or halo;
X4 is S, O, or N(R10);
R1 is selected from

wherein R4 is selected from the group consisting of:
1) Hydrogen;
2) Substituted or unsubstituted —C1-C8 alkyl;
3) Substituted or unsubstituted —C2-C8 alkenyl;
4) Substituted or unsubstituted —C2-C8 alkynyl;
5) Substituted or unsubstituted —C3-C8 cycloalkyl;
6) Substituted or unsubstituted aryl;
7) Substituted or unsubstituted arylalkyl;
8) Substituted or unsubstituted 3- to 8-membered heterocycloalkyl;
9) Substituted or unsubstituted heteroaryl; and
10) Substituted or unsubstituted heteroarylalkyl;
R2, R3, R5 and R8 are each independently selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) —NO2;
4) Cyano;
5) Substituted or unsubstituted —C1-C8 alkyl;
6) Substituted or unsubstituted —C2-C8 alkenyl;
7) Substituted or unsubstituted —C2-C8 alkynyl;
8) Substituted or unsubstituted —C3-C8 cycloalkyl;
9) Substituted or unsubstituted aryl;
10) Substituted or unsubstituted arylalkyl;
11) Substituted or unsubstituted 3- to 8-membered heterocycloalkyl;
12) Substituted or unsubstituted 3- to 8-membered heterocycloalkyl-alkyl;
13) Substituted or unsubstituted heteroaryl;
14) Substituted or unsubstituted heteroarylalkyl;
15) —N(R6)(R7);
16) —S(O)2N(R6)(R7);
17) —N(R6) C(O)R7;
18) —N(R6) S(O)2R6; and
9) —OR6;
R6 and R7 are independently selected from the group consisting of hydrogen, —C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, wherein each —C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is optionally substituted with 1-3 substituents independently selected from halo, alkyl, cycloalkyl, alkylamino, dialkylamino, alkylC(O)NH—, arylC(O)NH—, heteroarylC(O)NH—, —CN, alkoxy, —CF3, aryl, and heteroaryl; alternatively, R6 and R7 are taken together with the nitrogen atom to which they are attached to form an optionally substituted heterocycloalkyl group; and
R10 is selected from the group consisting of hydrogen, —C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, wherein each —C1-C8 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl is optionally substituted with 1-3 substituents independently selected from halo, alkyl, cycloalkyl, alkylamino, dialkylamino, alkylC(O)NH—, arylC(O)NH—, heteroarylC(O)NH—, —CN, alkoxy, —CF3, aryl, and heteroaryl.

US Pat. No. 10,246,438

NON-SELECTIVE KINASE INHIBITORS

PULMOKINE, INC, Renssela...

1. A method of reducing phosphorylation of an extracellular signal-regulated kinase (ERK), the method comprising administering to a subject a therapeutically-effective amount of a compound of the formula:or a pharmaceutically-acceptable salt thereof.

US Pat. No. 10,246,437

CRYSTAL FORM OF NERATINIB MALEATE AND PREPARATION METHOD THEREFOR

Crystal Pharmatech Co., L...

1. A maleate crystalline Form C of the compound of Formula (I), wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 10.9±0.2°, 15.2°±0.2° and 23.5°±0.2°

US Pat. No. 10,246,434

QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof,
wherein
X1 is C;
Y1 is N or CH;
Y2 iS N or CR5;
Y3 is N or CR6;
Y4 is CR7;
R1 is —OH;
R2 is (C1-C6) alkyl, (C6-C14) aryl, (C3-C8) cycloalkyl, or heterocycloalkyl, wherein the alkyl, aryl, cycloalkyl, and heterocycloalkyl are optionally substituted with one or more R8;
R4 and R4? are H;
R5 is H;
R6 is H;
R7 is (C1-C6) alkyl or (C6-C14) aryl, wherein the alkyl and aryl are optionally substituted with one or more R14;
each R8 is independently (C1-C6) alkyl, halogen, —(C0-C4)-alkylene-aryl, —(C0-C4)-alkylene-heteroaryl, —(C0-C4)-alkylene-O-heteroaryl, or —C(O)R21, wherein the alkyl, alkylene, aryl, and heteroaryl are optionally substituted with one or more R9;
each R9 is independently (C1-C6) alkyl, halogen, or —NR23S(O)qR24;
each R14 is independently halogen, (C6-C14) aryl, or —O—(C3-C8)cycloalkyl, wherein in the aryl and cycloalkyl are optionally substituted with one or more R16;
each R16 is halogen;
each R21 is (C2-C6) alkenyl;
each R23 and R24 is independently H or (C2-C6) alkenyl;
m is 0;
n is 1; and
q is 2.

US Pat. No. 10,246,430

METHODS FOR PRODUCING BERAPROST AND ITS DERIVATIVES

Lung Biotechnology PBC, ...

1. A method of preparing a compound represented by the structural Formula (I):
and salts thereof; comprising:
(a) reacting a substituted halophenol with 6-oxabicyclo[3.1.0]hex-2-ene in presence of a palladium catalyst to form an ether compound represented by structural Formula (III):

(b) acetylating the ether compound of Formula (III) to form a compound of Formula (IV)

(c) allylating the compound of Formula (IV) with allyltributylstannane in presence of AIBN to form the allylation product (V)

(d) subjecting the terminal alkene compound of Formula (V) to intermolecular allylic acetoxylation to form a compound of Formula (VI)

(e) subjecting the compound of Formula (VI) to dihydroxylation to form a compound of Formula (VII)

(f) subjecting the dihydroxy compound (VII) to oxidation to form an aldehyde compound of Formula (VIII)

(g) reducing the aldehyde compound of Formula (VIII) and removing the acetyl group to provide the diol compound of Formula (IX); and

(h) converting the diol of Formula (IX) to a protected aldehyde of Formula (VIIIA); and

(i) reacting the protected aldehyde of Formula (VIIIA) with a phosphonate of Formula (X) to obtain a compound of Formula (I)
wherein:X is F, Cl, Br or I;
R1 is an alkyl, cycloalkyl or TBDMS;
R2 is independently H or an alcohol protecting group;
R3 is a straight or branched alkyl group having 1-4 carbon atoms; and
R6 is an alcohol protecting group.

US Pat. No. 10,246,424

SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF

Araxes Pharma LLC, San D...

1. A compound having the following structure (I):or a pharmaceutically acceptable salt or stereoisomer or thereof, wherein:A is N;
G1 and G2 are each independently N or CH;
L1 is a bond or NR7;
L2 is a bond or alkylene;
R1 is aryl or heteroaryl;
R2a, R2b and R2c are each independently H, amino, cyano, halo, hydroxyl, C1-C6 alkyl, C1-C6 alkylaminyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; C3-C8 cycloalkyl, heterocyclylalkyl, C2-C6 alkynyl, C2-C6 alkenyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl, aminylcarbonyl, heteroaryl or aryl;
R3a and R3b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, heterocyclylalkyl, C2-C6 alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl; or R3a and R3b join to form oxo, a carbocyclic or heterocyclic ring; or R3a is H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, heterocyclylalkyl, C2-C6 alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl, and R3b joins with R4b to form a carbocyclic or heterocyclic ring;
R4a and R4b are, at each occurrence, independently H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, heterocyclylalkyl, C2-C6 alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl; or R4a and R4b join to form oxo, a carbocyclic or heterocyclic ring; or R4a is H, —OH, —NH2, —CO2H, halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C8 cycloalkyl, heterocyclylalkyl, C2-C6 alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl or aminylcarbonyl, and R4b joins with R3b to form a carbocyclic or heterocyclic ring;
R5a and R5b are, at each occurrence, independently H, hydroxyl, halo or C1-C6 alkyl, or R5a and R5b join to form oxo;
R6 is amino, cyano, substituted alkyl or substituted or unsubstituted: haloalkyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, C1-C6 alkylphosphoryl, C1-C6 alkylphosphorylaminyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, heteroarylalkyloxy or heteroarylalkylaminyl when R1 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; or R6 is methyl when R1 is substituted aryl or substituted or unsubstituted heteroaryl;
R7 is, at each occurrence, independently H, C1-C6 alkyl, C3-C8 cycloalkyl or heterocyclyl;
m1 and m2 are each independently 1, 2 or 3;
n is an integer from 0 to 6;
X is a bond, —O—, —NR7— or —S—; and
E is an electrophilic moiety capable of forming a covalent bond with the cysteine residue at position 12 of a KRAS, HRAS or NRAS G12C mutant protein,
wherein each occurrence of alkyl, alkylene, aryl, heteroaryl, heterocyclyl, alkenyl, alkynyl, hydroxylalkly, alkoxyalkyl, aminylalkyl, alkylaminylalkyl, cyanoalkyl, carboxyalkyl, aminylcarbonylalkyl, alkylphosphoryl, alkylphosphorylaminyl, aminylcarbonyl, alkylaminyl, haloalkyl, alkoxy, haloalkoxy; cycloalkyl, heterocyclylalkyl, heteroarylalkyloxy, heteroarylalkylaminyl and carbocyclic and heterocyclic rings is optionally substituted with one or more substituents unless otherwise specified, the optional substituents being selected from the group consisting of aminyl, cyano, hydroxyl, imino, nitro, oxo, thioxo, halo, aminylsulfonyl, aminylcarbonyl, C1-C12 alkyl, C1-C6 alkylaminylcarbonyl, aminylcarbonylC1-C6 alkyl, C1-C12 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkoxyalkyl, C1-C6 haloalkoxyalkyl, cyanoC1-C6 alkyl, C1-C6 alkylcycloalkyl, C1-C6 alkylheterocycloalkyl, C2-C6 alkynyl, C1-C6 alkylaminyl, C1-C6 alkylcarbonylaminyl, C1-C6 hydroxyalkyl, C2-C6 alkenylcarbonylaminyl, C1-C6 thioalkyl, aryl, aralkyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, aminylcarbonylC3-C8 cycloalkyl, C3-C8 cycloalkylaminylcarbonyl, C3-C8 fused cycloalkyl, heterocyclyl, N-heterocyclyl, heterocyclylalkyl, heteroaryl, N-heteroaryl and heteroarylalkyl, and
wherein: i) each aryl comprises a 6- to 18-membered carbocyclic aromatic ring radical; ii) each heterocyclyl comprises a 3- to 18-membered non-aromatic ring radical having one to twelve ring carbon atoms and from one to six ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and iii) each heteroaryl comprises a 5- to 14-membered ring radical comprising hydrogen atoms, one to thirteen ring carbon atoms, one to six ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and at least one aromatic ring.

US Pat. No. 10,246,421

INDAZOLYL- AND INDOLYL-BENZAMIDE DERIVATIVES

Esanex, Inc., Indianapol...

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein
bond “” is a single or a double bond;
R3 is hydrogen, halogen, cyano, —C(O)OH, —C(O)—O(C1-C6 alkyl), —N(RN)2, C1-C6 alkyl,
C1-C6 alkoxy, C1-C6 haloalkyl, C3-C7 cycloalkyl, aryl, or heteroaryl, wherein;
each alkyl, cycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide; and each RN is independently hydrogen or —C1-C6 alkyl-;
R4 and R5 are independently hydrogen or halogen;
R6 is halogen or —Z1RZ1, and wherein
Z1 is —O—, —NH—, —S(O)p—, or —S(O)2NH—, wherein p is 0, 1 or 2; and
RZ1 is a C1-C14 alkyl group where up to five of the carbon atoms in the alkyl group are optionally replaced independently by R22, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO2, and SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent to each other, and
R22 is heteroaryl, aryl, saturated or unsaturated C3-C10 cycloalkyl, or saturated or unsaturated C2-C10 heterocycloalkyl, wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl, or saturated or unsaturated heterocycloalkyl, independently, is optionally substituted with at least one group, which independently is hydroxy, halo, amino, cyano, carboxy, carboxamido, nitro, oxo, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, (C1-C6)alkoxy, or mono- or di-(C1-C10)alkylamino; and wherein each is optionally fused to a C6-C10 aryl group, C5-C8 saturated cyclic group, or a C5-C10 heterocycloalkyl group;
and wherein RZ1 optionally substituted at any available position independently with C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, C1-C6 alkoxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy, mono- or di-(C1-C10)alkylamino, —OC1-C10 alkyl-Z, or R23, wherein
Z is OR31 or —N(R30)2, wherein
each R30 is independently hydrogen or C1-C6 alkyl, or N(R30)2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl, or morpholinyl, each of which is optionally substituted with hydroxy, amino, aminoalkyl, C1-C6 alkyl, mono- or di(C1-C6)alkylamino, C1-C6 alkoxy, or halogen;
R31 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, or C1-C6 acyl;
R23 is heteroaryl, aryl, saturated or unsaturated C5-C10 cycloalkyl, or saturated or unsaturated C5-C10 heterocycloalkyl, and each is optionally substituted with at least one group which is independently hydroxy, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, C1-C6 alkoxy, or mono- or di-(C1-C10)alkylamino;
R9 and R10 are independently hydrogen or C1-C8 alkyl; or R9 and R10 taken together with the carbon atom to which they are attached form C3-C8 cycloalkyl;
R1 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C1-C10 alkoxy, mono- or di-(C1-C10)alkylamino, C1-C10 alkoxy(C1-C10)alkyl, hydroxy(C1-C10) alkoxy, or amino(C1-C10)alkoxy-;
R41 is a group of the formula

 wherein
R1 and R2 are independently H, hydroxy, C2-C6 alkenyl, C2-C6 alkynyl, heteroaryl, aryl, C3-C8 cycloalkyl, heterocycloalkyl, wherein
each cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide;
X4 is oxygen;
X is N or CRC; and
Y is N or CRC;
each RC is independently is hydrogen, halogen, cyano, nitro, —C(O)RC1, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C10)alkyl, heterocycloalkyl, aryl, or heteroaryl, wherein
each alkyl, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, cyano, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, carboxamide, heterocycloalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl groups are optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, or carboxamide;
RC1 is —C1-C6 alkyl, —ORC2, or —N(RCN)2, wherein
RC2 is —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
each RCN is independently —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, C1-C6 acyl, aryl, or heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide.

US Pat. No. 10,246,412

CHEMICAL FILM ON SUBSTRATE AND METHOD OF FORMING THE SAME, METHOD OF FORMING PARACYCLOPHANE CONTAINING FUNCTIONAL GROUND WITH DISULFIDE BOND

MAY-HWA ENTERPRISE CORPOR...

1. A method of forming a chemical film comprising:providing a substrate;
performing a chemical vapor deposition (CVD) process to form a chemical film on the substrate, wherein the chemical film comprises poly-p-xylylene with disulfide functional group, wherein monomer of the poly-p-xylylene is formed by adding 3,3?-dithiodipropionic acid and N-ethyl-N?-(3-(dimethylamino)propyl)carbodiimide into 4-aminomethyl [2,2] paracyclophane, thereby obtaining a paracyclophane comprising a disulfide functional group.

US Pat. No. 10,246,402

FRUITY ODORANT

Firmenich SA, Geneva (CH...

1. A perfuming ingredient in the form of a composition for providing a fruity odor note which is devoid of herbaceous notes, the ingredient comprising:i) at least a compound of formula (I):
in the form of any one of its stereoisomers or of a mixture thereof, wherein R1 represents a C2-3 alkyl or alkenyl group, R2 represents a methyl or ethyl group, R3 represents a C1-4 alkyl or alkenyl group and the compound has from 9 to 12 carbon atoms, provided that (1S)-2-ethoxy-1-methyl-2-oxoethyl pyruvate is excluded;ii) at least one ingredient selected from the group consisting of a perfumery carrier and a perfumery base; and
iii) optionally at least one perfumery adjuvant.

US Pat. No. 10,246,394

SEPARATION PROCESSING METHOD FOR A PRODUCT STREAM OF A DIMETHYL ETHER REACTOR

1. Method for the processing, by separation technology, of a product stream (g) containing at least dimethyl ether, methanol, water, carbon dioxide, carbon monoxide and hydrogen, from a reactor (4) used for the synthesis of dimethyl ether from synthesis gas (e), comprisingfeeding the product stream (g), in at least partially gaseous form, into an absorption column (6) operated with a liquid reflux, removing a gaseous top stream (m) from the absorption column (6) at the top and removing a liquid sump stream (p) at the bottom,
feeding the sump stream (p) at least partially into a first distillation column (5), withdrawing a transfer stream (q) containing dimethyl ether and a stream (r) predominantly containing methanol and/or water from the first distillation column (5),
cooling the top stream (m) at least partially initially to a first temperature level and subsequently further cooling to one or more further temperature levels, forming a first condensate stream (n) after the cooling to the first temperature level and forming one or more further condensate streams (s, t) after the further cooling to the further temperature level or levels, and
using the first condensate stream (n) partially to form the liquid reflux and feeding the further condensate stream or streams (s, t) at least partially into a further distillation column (9), from which removing a liquid stream (z) predominantly containing dimethyl ether and poor in or free from carbon dioxide at the bottom.

US Pat. No. 10,246,378

BUILDING PRODUCTS COMPOSITES AND METHODS

Georgia-Pacific Gypsum LL...

1. A composite, comprising:a nuclei seeding agent comprising dihydrate calcium sulfate whiskers; and
dihydrate calcium sulfate crystals formed about the dihydrate calcium sulfate whiskers, such that the composite has a natural porosity of about 60 volume percent or greater and a density of about 40 lb/ft3 or less,
wherein the composite does not contain a foaming agent or microspheres.

US Pat. No. 10,246,372

BLUE COLORED HEAT TREATABLE COATED ARTICLE HAVING LOW SOLAR FACTOR VALUE

Guardian Europe S.A.R.L.,...

1. A coated article having blue glass side reflective coloration and including a layer system supported by a glass substrate, the layer system comprising:a first dielectric layer comprising silicon nitride;
a first infrared (IR) reflecting layer comprising NbZr on the glass substrate over at least the first dielectric layer comprising silicon nitride;
a second dielectric layer comprising silicon nitride on the glass substrate over at least the first dielectric layer comprising silicon nitride and the first IR reflecting layer comprising NbZr;
a second layer IR reflecting layer comprising NbZr on the glass substrate over at least the second dielectric layer comprising silicon nitride;
wherein the second dielectric layer comprising silicon nitride is located directly between and contacting the first and second IR reflecting layers comprising NbZr;
a third dielectric layer comprising silicon nitride on the glass substrate over at least the second IR reflecting layer comprising NbZr;
wherein the coated article contains no metallic infrared (IR) reflecting layer based on Ag and/or Au, and wherein the IR reflecting layers do not physically contact any other metallic or substantially metallic layer; and
wherein the coated article: has glass side visible reflectance of no greater than 18%, a film side/interior reflective a* color value of ?2 to +12, glass side/exterior reflective blue coloration comprising a glass side/exterior b* color value of from ?8.0 to ?30.0; and (i) if measured monolithically has an SF value of no greater than 0.35 and an SHGC value of no greater than 0.40, and/or (ii) if an insulating glass (IG) window unit having two glass substrates has an SF value of no greater than 0.25 and an SHGC value of no greater than 0.27.

US Pat. No. 10,246,357

SYSTEM AND METHODS FOR REMOVING MINERALS FROM A BRINE USING ELECTRODIALYSIS

Enviro Water Minerals Com...

1. A method, comprising:treating a first brine stream comprising a plurality of minerals with an anti-sealant to produce a treated brine, wherein the first brine stream is provided by a wastewater treatment system;
directing the treated brine to a first nanofiltration (NF) system disposed downstream from and fluidly coupled to the wastewater treatment system;
generating a first NF permeate stream and a first NF non-permeate stream from the treated brine in the first NF system;
directing the first NF non-permeate stream to a mineral removal system disposed downstream from and fluidly coupled to the first NF system;
removing the plurality of minerals from the first NF non-permeate stream to generate a first overflow stream in the mineral removal system; wherein the first overflow stream comprises at least a portion of the plurality of minerals;
routing a first portion of the first overflow stream to a hydrochloric acid (HCl) and sodium hydroxide (NaOH) production system disposed downstream from and fluidly coupled to the mineral removal system, wherein the HCl and NaOH production system comprises a second NF system configured to receive the first portion of the first overflow stream and to generate a second brine stream from the first portion of the first overflow stream; and
directing the second brine stream to a first electrodialysis (ED) system disposed within the HCl and NaOH production system and fluidly coupled to the second NF system, wherein the first ED system is configured to generate HCl and NaOH from the second brine stream.

US Pat. No. 10,246,356

APPARATUS FOR REMOVAL OF IONS COMPRISING MULTIPLE STACKS

VOLTEA B.V., Sassenheim ...

1. An apparatus to remove ions, the apparatus comprising:multiple stacks, each stack comprising:
a first electrode,
a second electrode, and
a spacer, in between the first and second electrodes, allowing water to flow in between the first and second electrodes;
wherein at least one of the stacks comprises a tray configured to hold and position the at least one stack within a housing of the apparatus and the tray comprises:
a positioning alignment feature that is movable with the tray relative to the housing, the positioning alignment feature configured to position, on the tray, one or more selected from: the first electrode, the second electrode, the spacer or a charge barrier, by physical contact with the one or more selected from: the first electrode, the second electrode, the spacer or a charge barrier; and
a rim extending substantially perpendicularly to a surface of the tray, the surface facing a surface of the first electrode, the second electrode, or both the first electrode and the second electrode.

US Pat. No. 10,246,322

DISTRIBUTED SENSOR SYSTEM

Versana Micro Inc., Scot...

1. A distributed sensor system comprising:a first sensor node comprising a plurality of sensors formed on or coupled to a substrate;
a first flexible interconnect region coupled to the first sensor node;
a first joint region coupled to the first flexible interconnect region;
a second flexible interconnect region coupled to the first joint region; and
a second sensor node coupled to the second flexible interconnect wherein the first joint region is configured to be decoupled from the first flexible interconnect region or the second flexible interconnect region wherein the first joint region is replaced with a second joint region that is shorter or longer than the first joint region when recoupled to the first flexible interconnect region or the second flexible interconnect region such that the length between the first sensor node and the second sensor node is decreased or increased.

US Pat. No. 10,246,316

ANTI-SPILL FUNNEL ASSEMBLY

J.N.S. TECHNOLOGIES, LLC,...

1. An anti-spill funnel assembly for preventing the spill of fluid when the funnel assembly is being used to fill a container with fluid, comprising:an outer reservoir funnel including:
(a) a hollow cone-shaped portion having an upper end, a lower end, an outer surface, and an inner surface;
(b) a hollow inwardly tapered spout having an upper end, a lower end, an outer surface, and an inner surface;
(c) said upper end of said tapered spout being joined to said lower end of said cone-shaped portion;
(d) said upper end of said cone-shaped portion having a first diameter;
(e) said lower end of said cone-shaped portion having a second diameter which is less than said first diameter;
(f) said tapered spout extending outwardly and downwardly at an angle from said lower end of said cone-shaped portion to define a first interior shoulder therebetween;
(g) a plurality of elongated and radially spaced-apart first ribs, having upper and lower ends, extending outwardly from said outer surface of said cone-shaped portion, at said lower end thereof, and said outer surface of said tapered spout;
a center funnel positioned in said outer funnel;
said center funnel including:
(a) a cone-shaped portion having an upper end, a lower end, an outer surface, and an inner surface;
(b) said upper end of said cone-shaped portion of said center funnel having a diameter which is less than said first diameter of said upper end of said cone-shaped portion of said outer reservoir funnel;
(c) said lower end of said cone-shaped portion of said center funnel having a diameter which is less than said second diameter of said lower end of said cone-shaped portion of said outer reservoir funnel;
(d) a hollow stem portion having an upper end, a lower end, an inner surface and an outer surface;
(e) said upper end of said hollow stem portion being joined to said lower end of said cone-shaped portion of said center funnel;
(f) said hollow stem portion having an outwardly tapered portion, at said lower end thereof, having upper and lower ends;
(g) a plurality of elongated and radially spaced-apart second ribs, having upper and lower ends, extending outwardly from said outer surface of said cone-shaped portion of said center funnel, at said lower end thereof, and said outer surface of said hollow stem portion at said upper end thereof;
(h) a hollow spout portion having upper and lower ends;
(i) said hollow spout portion of said center funnel including an inwardly tapered portion, having upper and lower ends, at said upper end thereof;
(j) said upper end of said inwardly tapered portion of said spout portion of said center funnel being joined to said lower end of said stem portion thereof to define an exterior shoulder therebetween;
(k) said lower end of said spout portion of said center funnel being inwardly tapered;
(l) a plurality of elongated and radially spaced-apart openings, having upper and lower ends, formed in said stem portion;
said exterior shoulder between said lower end of said stem portion of said center funnel and said tapered portion of said spout portion of said center funnel engaging said interior surface of said spout of said outer reservoir funnel to limit the downward movement of said center funnel with respect to said outer reservoir funnel to an operative fill position;
when said center funnel is in said operative fill position:
(a) said cone-shaped portions of said outer reservoir funnel and said center funnel are spaced-apart;
(b) said exterior shoulder preventing overfill fluid from passing upwardly from said lower end of said tapered spout of said outer reservoir funnel;
(c) said openings in said stem portion permitting overfill liquid to pass outwardly therethrough into said lower end of said cone-shaped portion of said outer reservoir funnel thereby preventing liquid from being spilled.

US Pat. No. 10,246,286

CONVEYOR FOR WEB

VITS TECHNOLOGY GMBH, La...

1. A system having a plurality of treatment stations arrayed along a horizontal treatment path, the system comprising:a conveyor having a guide extending horizontally and displaceable in a direction through the stations from an upstream end to a downstream end of the path;
intake means for feeding an end of a web to the upstream end of the path;
a bar magnet carried on the conveyor and extending a full width of the web;
a first holder above the path adjacent the upstream end;
a magnetizable metal plate in the first holder, whereby movement of the conveyor displaces the bar magnet underneath the web at the first holder and attracts the magnetizable metal plate; and
a picker on the bar magnet configured to engage with the magnetizable metal plate on advancement of the bar magnet past the magnetizable metal plate, and sweep the magnetizable metal plate off the first holder onto the web and thereby magnetically press the web with the magnetizable metal plate against the guide and entrain the web with the conveyor.

US Pat. No. 10,246,284

MACHINE FOR WINDING OF PRE-STRETCHED FILM REELS

NO.EL. S.R.L., San Pietr...

1. Machine for producing coils of prestretched extendible film comprising a prestretching unit for prestretching a film and a winding unit for winding the film in a coil, said prestretching unit being provided with a series of prestretching rollers around which the film is prestretched, wherein the winding unit comprises a winding roller in pressing contact against a coil of the prestretched film in winding progress along length, said coil being provided with a required diameter, wherein said machine comprisesan actuator acting on the winding roller to achieve a pressing contact against the coil; and
an abutting member acting in an opposite direction to the actuator for varying a final contact position of the winding roller against the coil according to the length of the film and according to the required diameter of the coil.

US Pat. No. 10,246,283

VERTICAL WALL WEBBING INSTALLATION METHOD AND SYSTEM

Pacific Coast Building Pr...

1. A system for installing rolled sheet material on a wall comprising:a material spool holder mounted to a piece of movable construction equipment comprising a vertical shaft sized to fit within an open core of a roll of sheet material, a rotatable base to support the roll of sheet material mounted on the vertical shaft, and a vertical mounting plate mounted to the piece of movable construction equipment that is connected to a vertical support beam with a hinge and a releasable attachment mechanism spaced apart from the hinge;
a horizontal support beam;
wherein the horizontal support beam extends between and connects the vertical shaft and vertical support beam, and
further comprising a rotation limiting device wherein the rotation limiting device is a rope that limits an amount of downward rotation of the vertical support beam around the hinge after the releasable attachment mechanism is released.

US Pat. No. 10,246,279

IMPACT VEHICLE RESTRAINT WITH STRUCTURED IMPACT ZONE

1. An impact vehicle restraint for securing a trailer to a loading dock, the loading dock having a face wall and the trailer having an ICC bar, said impact vehicle restraint comprising:a track anchored proximal the face wall of the dock;
a carriage joined to said track and movable between upper and lower ICC bar engaging positions, said carriage having shear plates with forward sloped ends, and a hook rotatably secured between said shear plates and selectively movable along a path of travel between retracted and deployed positions;
a motor held by and traveling with said carriage, said motor being drivingly connected to said hook via a hook pivot pin to selectively deploy and retract said hook;
a structured ramp impact zone formed by a central impact plate and a ramp extension leg, said central impact plate having upper and lower plate surfaces and opposed plate sides, said impact plate being held by and traveling with said hook and being in a ramp forming position when said hook is in said retracted position, said opposed plate sides supportably engaging said forward sloped ends of said shear plates and said upper plate surface forming an angularly fixed ramp plane when in said ramp forming position, said ramp extension leg being rotatably mounted between said shear plates, said extension leg having an upper leg surface and a lower leg end and being movable between ramp forming and collapsed positions, said upper leg surface being in overlapping alignment with said upper plate surface and forming said structured ramp impact zone when said leg is in its said ramp forming position, and said lower leg end rotating forward when in said collapsed position; and,
wherein said hook is behind said ramp plane when in said retracted position and passes through said ramp plane when moving along said path of travel between retracted and deployed positions, and the ICC bar pressingly engages and smoothly travels along said structured ramp impact zone between said extension leg and impact plate when engaging said carriage.

US Pat. No. 10,246,276

CABLE-STRUT COMBINATION DRIVEN PARALLEL ROBOTIC PALLETIZER

Hefei University of Techn...

1. A combined rope-rod-driven parallel palletizing robot, comprising:a base driving mechanism arranged on a chassis, the base mechanism comprising a base-driving internal torque structure and a base-driving external torque structure, wherein the base-driving internal torque structure and a base-driving external torque structure are driven by a plurality driving motors to generate torque internally and externally respectively;
a torque transfer mechanism mounted on the base driving mechanism, the torque transfer mechanism comprising an external torque transfer mechanism and an internal torque transfer mechanism,
the external torque transfer mechanism, including six steel transfer wire ropes, transferring a first torque from a base torque output disk to a top gearbox mounted on the top of the torque transfer mechanism;
an internal torque transfer mechanism transferring a second torque from a base internal torque transfer shaft affixed to the torque transfer mechanism to the a gearbox on a gib arm; wherein the first and second torque is converted by the top gearbox to drive the gib arm to rotate and lift;
the gib arm, movably connected to the top gearbox, comprising
a forearm mounted on the lower part of a top gearbox lower torque output shaft extending from the top gearbox;
a movable end comprising a mechanical arm end tool arranged on the movable end of the gib arm and configured to operate a work object;
three steel wire rope drivers located on the chassis and arranged evenly around the base driving mechanism, with three steel outer wire ropes corresponding to each of the three steel wire rope drivers;
wherein when the robot is driven such that the combined rope-rod-driven parallel palletizing robot performs handling and palletizing actions.

US Pat. No. 10,246,273

TRIM REMOVAL SYSTEM

ALLIANCE MACHINE SYSTEMS ...

1. A method for removing trim from sheets, the method comprising:conveying a sheet over a plurality of wheels in a direction of travel, the wheels positioned spaced apart in both the direction of travel and in a direction transverse to the direction of travel in a manner to permit trim to pass therethrough; and
propelling air, via one or more air chambers toward the sheet to remove trim from the sheet.

US Pat. No. 10,246,265

BELT CONVEYOR SYSTEM

Custom Agri Systems, Inc....

1. A belt conveyor system, comprising:a main housing; and
a troughing idler assembly disposed in the main housing, the troughing idler assembly including at least one roller supported by a first bearing having a first face and a second face and a second bearing having a first face and a second face, wherein the first bearing is mounted to an exterior of the main housing, wherein the first face and the second face of the first bearing are at least partially visible, and wherein at least one of the first bearing and the second bearing is disposed in a bearing bracket housing coupled to the main housing.

US Pat. No. 10,246,230

SAFETY CLOSURE FOR CONTAINERS

LUMSON S.P.A., Capergnan...

1. A safety closure for containers comprising a cover and an internal element, the internal element being formed by a constraining portion and by a covering portion, that after use may be positioned again on the container, the covering portion and the constraining portion being interconnected by at least a first preferential breakage zone which, when intact, joins them to each other, the constraining portion being provided with blocking means at the neck of a container with which the closure is intended to be associated, and first removable constraining means associated with the cover, the internal element having sealing means which, at least when the seal is intact, preserve the container content integrity;wherein the sealing means is located on the covering portion and/or wherein the sealing means comprises an annular lip projecting from the covering portion and adapted to cooperate with an internal edge of a mouth of the container with which the closure is intended to be associated;
wherein the covering portion may be reapplied and covered by the cover.

US Pat. No. 10,246,225

METHOD AND APPARATUS FOR ENCLOSING

United Sources Sought, In...

1. A dispenser assembly comprising:(a) a watertight bag having a first opening and a second opening;
(b) a first closure configured to repeatedly open and seal the first opening;
(c) a second closure configured to repeatedly open and seal the second opening; and
(d) a powder ball retained relative to the bag, the powder ball having at least one of a dispensable drying powder and a dispensable moisture absorbing powder.

US Pat. No. 10,246,217

CAN SHELL AND DOUBLE-SEAMED CAN END

Ball Corporation, Broomf...

1. A one piece metallic end closure adapted for double seaming to a neck of a container, comprising:a substantially circular center panel with a vertical center axis;
a peripheral curl having a first end and a second end, said first end adapted for interconnection to the neck of the container;
a countersink having an outer panel wall and an upwardly and inwardly oriented inner panel wall, said outer panel wall oriented at a first angle between about 3 degrees and about 19 degrees with respect to said vertical center axis, wherein said countersink is further defined by a first radius of curvature below said inner panel wall and a second radius of curvature below said outer panel wall;
a beveled panel wall interconnected on an upper end to said substantially circular center panel at a third radius of curvature and integrally interconnected on a lower end to an upper end of said upwardly and inwardly oriented countersink inner panel wall, said beveled panel wall oriented at a second angle between about 30 and 60 degrees with respect to said vertical center axis and having a substantially uniform thickness; and
a chuck wall comprising an upper wall portion interconnected to said second end of said peripheral curl and a lower wall portion extending inwardly and downwardly and interconnected to said countersink outer panel wall, wherein said upper chuck wall portion is interconnected to said lower chuck wall portion at a break forming wall portion which defines a delineation in a radius of curvature, and wherein said substantially circular center panel is elevated above said break forming wall portion of said chuck wall.

US Pat. No. 10,246,212

CONTAINER STORAGE SYSTEM AND SUPPORT AND CROSS BAR OF SUCH A CONTAINER STORAGE SYSTEM

Kobeck GBR, Pleiskirchen...

1. Container storage system for the transport and/or securing of goods delivered in a container and/or for the subdividing of the container, wherein the container has side walls of trapezoidal sheet with vertical creases, wherein the container storage system comprises:at least two side supports, which can be arranged vertically in at least two opposite creases of at least two opposite side walls of the container, wherein the supports each have at least one recess which can be oriented toward the inside of the container to accommodate a cross bar and at least one bearing element is provided in the recess to brace the cross bar,
at least one cross bar, which can be installed in the at least two recesses in the at least two supports and which joins together the two supports in the mounted state,
and the container storage system can be assembled and disassembled without the use of tools, characterized in that the at least two supports can be installed in a crease optionally by the front side or the rear side and/or vertically rotated, wherein the front sides and rear sides of the at least two supports have a different number and/or height of the bearing elements along longitudinal axes of the at least two supports.

US Pat. No. 10,246,195

ARCHED INFLATABLE STRUCTURE FOR EVACUATION SLIDE SYSTEMS

GOODRICH CORPORATION, Ch...

1. An evacuation slide, comprising:a first side tube extending longitudinally between a head end and a toe end of the evacuation slide;
a second side tube extending longitudinally between the head end and the toe end of the evacuation slide;
a center tube extending longitudinally between the head end and the toe end of the evacuation slide;
an arched tube extending between the first side tube and the second side tube of the evacuation slide, the arched tube extends substantially orthogonal to the center tube, wherein the arched tube is separate from the center tube and is configured to contact the center tube in response to the evacuation slide being deployed; and
a strap coupled between the arched tube and the center tube of the evacuation slide,
wherein the arched tube is configured to provide vertical support to the first side tube and to the second side tube in response to a tension in the strap.

US Pat. No. 10,246,183

PROPELLER IMPACT DETECTION AND FORCE REDUCTION

Kitty Hawk Corporation, ...

1. A system, comprising:a processor; and
a memory coupled with the processor, wherein the memory is configured to provide the processor with instructions which when executed cause the processor to:
detect a rotor strike including by comparing a commanded control signal against an adaptive control signal, wherein the rotor strike is caused by a rotor included in an aircraft striking an object and the adaptive control signal is associated with controlling the rotor and the adaptive control signal varies based at least in part on the commanded control signal and state information associated with the rotor; and
in response to detecting the rotor strike, adjust a control signal to the rotor to change rotation of the rotor to reduce a striking force applied to the object being struck by the rotor and prevent damage to at least one of the object being struck and the rotor during at least one of: take-off, landing, and flying at a steady altitude.

US Pat. No. 10,246,176

AUTOMATED BALLOON LAUNCHING SYSTEM AND METHOD FOR LAUNCHING

Vaisala Oyj, Vantaa (FI)...

1. Automated balloon launching system for launching at least one balloon such as a meteorological balloon or a radiosonde, the system comprising:a container,
a storage arranged in the container for storing at least one box at a defined storage position p=1, 2, . . . , n, the at least one box including a balloon and a sonde,
a release silo arranged at least partially on top of or above and adjacent to the container for sheltering the balloon during inflation, and
a x-, y- and z-manipulator arranged in the container for feeding the storage with at least one box, and/or removing a specific box from one of the defined storage positions p=1, 2, . . . , n and subsequent feeding the release silo with the specific box through an opening in the container.

US Pat. No. 10,246,170

ELECTRIC FIN STABILIZER

Naiad Maritime Group, Inc...

1. A marine vessel stabilizer comprising:a fin having a stem extending therefrom, the stem configured to extend through a hull of the marine vessel, the stem having an end;
a fixed housing receiving said stem through a hole in said fixed housing,
the stem configured to rotate in said hole;
an arm connected to the end and extending away from the end at a distance to a connector such that the connector is spaced apart from a center of the stem to create a lever;
a linear actuator mechanism connected to said arm; and
a removable stop configured to engage said fixed housing and said arm such that when said removable stop is engaged, said fin is in a pre-determined position.

US Pat. No. 10,246,165

DISMANTLABLE LINK, SUITABLE IN PARTICULAR FOR INTERCONNECTING TWO CHAINS FOR ANCHORING FLOATING EQUIPMENT TO THE GROUND

NOV-BLM, Carquefou (FR)

1. A demountable link connecting two chains for the anchoring of a floating installation to the ground, the demountable link comprising:a studless link (1) shaped as an oblong ring, the studless link (1) being comprised of two rectilinear sections (2) connected by two bent sections (3),
the two rectilinear sections (2) being comprised of i) a first connecting part (5) having a first end portion (52) and an opposite second end portion (52), and ii) a second connecting part (5) having a third end portion (52) and an opposite fourth end portion (52),
the first and second connecting parts (5) extending along a respective longitudinal axis (2?) and being free of any stud extending therebetween,
the two bent sections (3) comprising a first bent section (3) and a second bent section (3),
the first bent section (3) being comprised of a first lateral part (6) connected to a second lateral part (6), the first lateral part (6) ending in a first end portion (62) and the second lateral part (6) ending in a second end portion (62),
the second bent section (3) being comprised of a third lateral part (6) connected to a fourth lateral part (2), the third lateral part (6) ending in a third end portion (62) and the fourth lateral part (6) ending in a fourth end portion (62); and
first and second removable fastening parts (7), wherein,
the first removable fastening part (7) removably connects the first end portion (62) of the first lateral part (6) of the first bent section (3) within the first end portion (52) of the first connecting part (5), and also removably connects the third end portion (62) of the third lateral part (6) of the second bent section (3) within the second end portion (52) of the first connecting part (5), and
the second removable fastening part (7) removably connects the second end portion (62) of the second lateral part (6) of the first bent section (3) within the third end portion (52) of the second connecting part (5), and also removably connects the fourth end portion (62) of the fourth lateral part (6) of the second bent section (3) within the fourth end portion (52) of the second connecting part (5).

US Pat. No. 10,246,160

PEDAL

1. A pedal comprising:a connection shaft configured to be coupled to a crank rod of a pedal exercise equipment;
a pedal body rotatably connected to the connection shaft and extending from the connection shaft in a horizontal direction, wherein the pedal body comprises a front surface and a rear surface;
a plurality of brake pads provided at a predetermined interval from each other on the front surface and the rear surface of the pedal body such that one side surface of each of the plurality of brake pads is in contact with the front surface or the rear surface of the pedal body; and
inclination control plates respectively positioned at the front surface and the rear surface of the pedal body, and having a plurality of brake mounting grooves which are formed on one surface thereof positioned adjacent to the front surface and the rear surface of the pedal body and into which the brake pads are inserted and fixed, a hinge screw through hole formed in the center thereof, and coupling screw through holes formed in the right side and left side portions of the inclination control plates, wherein the coupling screw through holes are in the shape of elongated holes, wherein a hinge screw is screw-coupled in a hinge screw coupling hole of the pedal body and the hinge screw through hole of the inclination control plate and a coupling screw hole is screw-coupled in a coupling screw coupling hole of the pedal body and the coupling screw through hole of the inclination control plate such that both the right side and left side portions of the inclination control plate pivot about the hinge screw in a vertical direction with respect to the pedal body.

US Pat. No. 10,246,156

AUDIBLE WARNING DEVICE FOR A BICYCLE

VELO SCIENTIFIC INC., To...

1. An audible warning device for a bicycle including a steerer column, the steerer column defining a longitudinal axis running through its center, the audible warning device comprising:a housing having a housing upper end;
a striking component connected to the housing and adapted to generate a sound by striking the housing; and
a mounting bolt extending longitudinally downwardly of the housing upper end for securing the housing to the steerer column,wherein, when the housing is secured to the steerer column, the housing upper end extends above the steerer column along the longitudinal axis.

US Pat. No. 10,246,146

FIFTH WHEEL HITCH

Automatic Equipment Manuf...

1. In a fifth wheel hitch having a hitch head with a throat and an opposing pair of jaws for connecting to a fifth wheel trailer having a kingpin with an annular groove, the improvement comprising:a latch lever having a lever orifice;
a lock lever having a lock orifice; and
one jaw of the opposing pair of jaws pivotally connected to the latch lever;
wherein, if the kingpin has been inserted into the throat of the hitch head, and the jaws are not seated in the groove of the kingpin, the lever and lock orifices are not alignable; and
wherein, if the kingpin has been inserted into the throat of the hitch head, and the jaws are seated in the groove of the kingpin, the lever and lock orifices are alignable.

US Pat. No. 10,246,115

FOOD, WATER AND VITAL SUPPLIES STORAGE AND TRANSPORT CART

ALLPILLARS, INC., Amity ...

1. A watertight collapsible storage and transport cart comprising:a substantially rectangular bottom panel;
two pairs of side panels connected to said bottom panel at fold lines, said fold lines being continuous and uninterrupted from end to end between said two pairs of side panels connected to said bottom panel;
a cover panel joined to a top edge of one of said side panels by a cover fold line, said cover panel having a rectangular shaped recess adjacent each corner thereof;
said panels being constructed of plastic material used to store food and water;
said side panels having releasable attachments where side edges of said side panels meet, said respective releasable attachments each comprising one pair of facing side panels having elongated continuous, uninterrupted male members extending along and on both side edges, and another pair of alternating facing side panels having continuous, uninterrupted female molded channels along side edges adapted to receive said continuous, uninterrupted male members when said side panels are lifted upwardly to form an assembled configuration of said cart, and forming along with uninterrupted fold lines watertight joints between adjacent side panels;
said bottom panel having a rectangular, annular metal frame L-shaped in cross section partially enclosing outer edges of said bottom panel and supporting a wheel adjacent each corner thereof, and a housing containing braking elements located over each wheel under said annular metal frame;
in said assembled configuration, said bottom and side panels extending upwardly forming a top opening, said cover panel swiveling between a position closing said top opening and a position exposing said top opening;
in a collapsed configuration, said sides folded inwardly, and said cover panel folded over said side panels, said folded panels forming a flat, compact assembly for stacking and storage, when stacked said wheels fall into corresponding recesses in a compact assembly underneath; and
a spout with a release valve mounted on said bottom panel for dispensing liquid contained within said cart.

US Pat. No. 10,246,100

SYSTEM AND METHOD FOR VEHICLE PATH PREDICTION

VEONEER SWEDEN AB, Varga...

1. A method of predicting a future path of a vehicle, comprising the steps of:sensing a speed, a direction, and a yaw rate of the vehicle;
sensing a steering angle of the vehicle; sensing a driving lane near the vehicle, or along which the vehicle is being driven;
calculating a first path prediction, for a first period of time following a current time, the first path prediction comprising a trajectory predicted based on the sensed speed, the sensed direction and the sensed yaw rate;
calculating a second path prediction, for a second period of time, at least some of which is later than the first period of time, which assumes that a steering action arising from changes in the steering angle will take effect on the vehicle;
calculating a third path prediction, for a third period of time, at least some of which is later than the second period of time, which assumes that the driver of the vehicle will control the trajectory of the vehicle to attempt to follow at least substantially the driving lane;
formulating a combined predicted path for the first, the second and the third periods of time, wherein the first, the second and the third path predictions each contribute to the combined predicted path; and
activating one or more vehicle safety systems if it is determined, based on the combined predicted path that the vehicle will, or is likely to, encounter a hazardous situation.

US Pat. No. 10,246,099

SYSTEM FOR THE ESTIMATION OF ONE OR MORE PARAMETERS RELATED TO THE LOAD OF A VEHICLE, PARTICULARLY OF THE ABSOLUTE VALUE AND THE DISTRIBUTION THEREOF

E-NOVIA S.R.L., Milan (I...

1. A system for the estimation of parameters (L, D) related to a load of a vehicle, said system comprising:first and second sensors for detecting respective first and second vehicle kinematic quantities, each sensor being suitable to generate signals representing the respective one of said vehicle kinematic quantities;
a control unit comprising:
first and second pairs of band-pass filters, each pair comprising first and second band-pass filters;
one or more modules for determining frequency spectra pairs (FFT1, FFT2), a frequency spectra pair being associated with each of said first and second vehicle kinematic quantities, from the signals representing the respective vehicle kinematic quantity filtered in a first and in a second predetermined frequency band through the first and second band-pass filters of a respective pair of the band-pass filters; and
one or more modules for determining a numeric value representing the vehicle load (L) in kilograms and a numeric value representing the load distribution (D) in the vehicle from said frequency spectra pairs (FFT1, FFT2),
wherein said numeric value representing the load distribution in the vehicle (D) represents the longitudinal distance of the concentrated load of the vehicle from a predetermined reference point,
wherein said numeric value representing the vehicle load (L) is a numeric absolute value representing the vehicle load (L), and said sensors comprise a sensor configured for detecting the vehicle vertical acceleration (z) and for generating a signal representing the vehicle vertical acceleration, and a sensor configured for detecting the vehicle pitch angular speed (?) and for generating a signal representing the vehicle pitch angular speed,
whereby the determination of said numeric value representing the vehicle load (L) and of said numeric value representing the load distribution in the vehicle (D) enables improvement in a stability of the vehicle.

US Pat. No. 10,246,068

PRESSURE MODULATOR FOR AN ABS SYSTEM

BRAKE FORCE ONE GMBH, Tu...

1. A pressure modulator for an antilock braking system (ABS), comprising:a housing having a hydraulic inlet and a hydraulic outlet that are interconnected via a hydraulic line;
a volume accumulator for increasing a volume of the hydraulic line during an activated anti-lock function;
a linear drive for opening the volume accumulator;
an electronic circuit disposed in the housing for controlling the linear drive;
a spring element, wherein the linear drive comprises a rotor bar and wherein a displacement movement of the rotor bar effectuates an opening of the volume accumulator against a spring force of the spring element; and
a control piston that extends into the rotor bar, the control piston being fixedly connected to the housing and supporting the spring element.

US Pat. No. 10,246,065

VEHICLE HAZARD DETECTION AND WARNING SYSTEM

THUNDER POWER NEW ENERGY ...

1. A vehicle apparatus, comprising:one or more input sensors;
an antenna device; and
a processor device configured to:
receive input from the one or more input sensors, the input including a location of a vehicle;
provide the received input to a service provider computer via the antenna device, wherein the service provider is caused to:
determine, based on the location of the vehicle, at least one hazard in a vicinity of the vehicle apparatus, the at least one hazard identified by a second vehicle traveling ahead of the vehicle using one or more sensors of the second vehicle;
identify one or more risks associated with the at least one hazard;
identify one or more driver-specific factors associated with the driver of the vehicle; and
determine, based on the one or more driver-specific factors associated with a driving tendency of the driver of the vehicle in combination with the one or more risks, a strategy for mitigating the at least one hazard, the strategy including at least a first set of instructions and a second set of instructions; and
receive, from the service provider computer and in response to providing the received input, the first set of instructions to provide a notification of at least one hazard in the vicinity of the vehicle apparatus to an operator of the vehicle apparatus, and the second set of instructions to activate one or more driving components of the vehicle to mitigate a risk posed by the at least one hazard based on one or more driver-specific factors; and
execute each of the first set of instructions and the second set of instructions.

US Pat. No. 10,246,062

SEMI-TRAILER LANDING GEAR

SAF-HOLLAND GmbH, Bessen...

1. A semi-trailer landing gear, comprising:a housing configured to fasten to a further element of a vehicle, wherein the semi-trailer landing gear extends along a longitudinal axis, the housing including an outer wall, the outer wall including a fastening side having at least two fastening portions located in the region of the fastening side, wherein each of the at least two fastening portions are configured to at least one of fasten and arrange the semi-trailer landing gear on the further element;
wherein each fastening portion of the at least two fastening portions includes at least one of at least one fastening element for fastening the at least one fastening portion and at least one arrangement portion for arranging the at least one fastening portion, and wherein a ratio of a distance between at least one of the fastening elements and the arrangement portions of the two fastening portions transversely to the longitudinal axis of the semi-trailer landing gear to a width of the housing in this region is less than 1, wherein the outer wall has at least one assembly opening that provides an access to the arrangement portion from an inner side of the semi-trailer landing gear, and wherein the assembly opening is configured to be closed by moving an inner supporting tube of the semi-trailer landing gear along the longitudinal axis, and wherein the assembly opening is closed in a first or rest position of the inner supporting tube.

US Pat. No. 10,246,046

VEHICLE SEATBELT ASSEMBLY

Nissan North America, Inc...

1. A vehicle seatbelt assembly comprising:a first member configured to attach to one of a vehicle floor structure and a seat structure;
a second member supported on the first member, the second member being configured for limited sliding movement relative to the first member;
a buckle mechanism attached to the second member for movement therewith, the buckle mechanism having a latch device configured to releaseably retain a seatbelt latch tongue member; and
a clutch mechanism disposed between the first member and the second member, the clutch mechanism being operable to switch between a dis-engaged state allowing movement of the second member relative to the first member and an engaged state preventing movement of the second member relative to the first member.

US Pat. No. 10,246,026

CAR TOP CARRIER AND HINGE THEREFOR

Impact Plastics Corporati...

1. A vehicle top carrier comprising:an upper storage container and a lower storage container combining to form the vehicle top carrier;
a lower hinge member being mounted on the lower storage container;
an upper hinge member being mounted on the upper storage container;
the upper hinge member joining with the lower hinge member to unite the lower storage container with the upper storage container in order to form the vehicle top carrier;
the upper hinge member being separable from the lower hinge member to provide storage for the vehicle top carrier;
the lower hinge member having at least one female assembly member or at least one male assembly member;
the upper hinge member having the at least one female assembly member or the at least one male assembly member;
the at least one female assembly member receiving the at least one male assembly member to form the vehicle top carrier;
the lower hinge member and the upper hinge member having the at least one female assembly member or the at least one male assembly member for each 100 centimeters length of a side of the upper storage container and an adjoining side of the lower storage container;
the at least one female assembly member and the at least one male assembly member being two to five pairs of female assembly members and male assembly members for each 100 centimeters in length of the upper hinge member and the lower hinge member;
the female assembly members having slot apertures, circular apertures, oval apertures, or rectangular apertures; and
the male assembly members corresponding to and fitting into the slot apertures, the circular apertures, the oval apertures, or the rectangular apertures;
the vehicle top carrier being a car top carrier;
the car top carrier providing ease of storage and ease of assembly;
the female assembly members and the male assembly members permitting easy joining and separation of the upper storage container and the lower storage container;
the upper storage container and the lower storage container being capable of a nesting arrangement when the lower hinge member and the upper hinge member are separated;
the upper storage container being a carrier top for the car top carrier;
the lower storage container being a carrier bottom for the car top carrier;
the female assembly members being mounted on the lower storage container;
the car top carrier including a prop for supporting the carrier top away from the carrier bottom in cooperation with a hinge formed by a joining of the lower hinge member and the upper hinge member;
the car top carrier being mountable a vehicle;
a mounting bracket being placed around a cross rail;
the cross rail being mounted on the vehicle;
a mounting bracket passing through bracket apertures in carrier bottom and then further through a back plate and into threaded knobs, thereby securing the car top carrier to the vehicle;
the carrier top being attached to carrier bottom by the hinge;
the hinge having a top hinge half secured to the carrier top and a bottom hinge half secured to the carrier bottom;
the top hinge half including at least one tongue;
the bottom hinge half including at least one receiving slot;
the at least one tongue fitting into the at least one receiving slot in male to female relationship;
at least one tongue of the at least one tongue including a safety aperture;
the safety aperture receiving a clip hook to prevent the tongue from leaving the receiving slot while the car top carrier is in use;
the clip hook being secured in the safety aperture in order to prevent an undesired separation of the top hinge half from the bottom hinge half;
a prop bar being mounted in the carrier bottom;
the prop bar being stored in carrier bottom as desired;
the prop bar cooperating with the hinge to raise the carrier top as desired;
the car top carrier including a lid lock to hold the car top carrier in a closed position;
the carrier top and the carrier bottom being are further secured by a bale latch;
the top hinge half joining to the bottom hinge half to form the hinge by placing a tongue of the top hinge half into a corresponding receiving slot of the bottom hinge half;
the tongue being stopped when the hinge is in a closed position;
the bottom hinge half being three in number and providing three of the receiving slots;
each of the three receiving slots accepting the tongue on the top hinge half;
the tongue fitting into the receiving slot in a male to female relationship;
a clip hook being inserted through the safety aperture in the tongue in order to prevent an undesired removal of the tongue from the receiving slot; and
a desired removal of the tongue from the receiving slot requiring a removal of the clip hook from the safety aperture.

US Pat. No. 10,246,018

STEP INSTALLATION STRUCTURE OF THE TRUCK

Shu-Ling Chen, Tainan (T...

1. A step installation structure of a truck comprising a step support and a fixing member, wherein:the step support comprises a base for connecting with a step assembly, and a frame member provided on a rear side of the base and configured to be inserted into a receiver hitch of the truck; the frame member has a sidewall defining a hollow channel and a plurality of perforations are formed on the sidewall, a position of each perforation corresponds to a position of a pin opening of the receiver hitch so that a depth of the frame member inserted into the receiver hitch can be adjusted;
the fixing member comprises a clamp body and a threaded bolt, the clamp body is configured to be inserted into the hollow channel of the frame member when assembled, and comprises a clip plate and a push plate which are arranged perpendicular to each other, the clip plate is provided with a screw nut thereon, the screw nut of the clip plate matches with the threaded bolt so that the screw nut of the clip plate and the threaded bolt clamp the frame member and the receiver hitch together; one end of the threaded bolt is provided with an anti-shedding member to prevent the threaded bolt from falling off due to severe vibration;
wherein the push plate is perpendicular to an axis of the hollow channel when assembled and is provided with a screw nut thereon matching with the threaded bolt, the threaded bolt is screwed into the screw nut of the push plate when assembling so that a user can hold the threaded bolt to align the screw nut of the clip plate with the perforations and the pin opening.

US Pat. No. 10,246,017

VIEW ANGLE ADJUSTMENT MECHANISM IN VIEW DEVICE

MURAKAMI CORPORATION, Sh...

1. A view angle adjustment mechanism in a view device, the view angle adjustment mechanism being configured to support a view element tilting section holding a view element by joining the view element tilting section to a tilting support section via a pivot so as to be capable of adjusting a view angle of the view element, wherein:the view angle adjustment mechanism includes a tilting actuator joined between the view element tilting section and the tilting support section, the tilting actuator causing a tilting force to act on the view element tilting section;
the tilting actuator includes a male thread member, a nut member, a gear member and a motor;
the male thread member is fixed, in an erected manner, to the tilting support section;
the nut member is threadably connected to the male thread member and is capable of moving in an axial direction of the male thread member upon being rotated in a direction of rotation around an axis of the male thread member;
a front end of the nut member is detachably fitted and joined to the view element tilting section at a position off the pivot of the view element tilting section;
the gear member is disposed coaxially with the nut member at a position in an outer circumference of the nut member;
the gear member is driven by the motor to rotate in the direction of rotation around the axis of the male thread member with movement of the gear member in the axial direction of the male thread member being prevented;
the nut member includes a plurality of legs each including a claw formed at an inner circumferential surface thereof, the claw being threadably connected to the male thread member, and a cylindrical barrel that supports the legs;
a protrusion that protrudes outward is formed at an outer circumferential surface of the barrel of the nut member;
an axially-extending groove is formed at an inner circumferential surface of the gear member;
the protrusion is fitted in the groove so as to be movable along the groove; and
a protrusion abutment portion provided at the tilting support section such that when the nut member moves in a direction in which the nut member comes off of the male thread member, the protrusion abutment portion abuts the protrusion and prevents further movement of the nut member in the coming-off direction.

US Pat. No. 10,246,013

AUTOMOBILE PROXIMITY WARNING SYSTEM

Shuichi TAYAMA, Tokyo (J...

1. An automobile proximity warning system comprising:a stereo camera including a pair of cameras for capturing images of a front of an own vehicle;
a plurality of parametric speakers arranged to emit warning sound outside the own vehicle from different front horizontal positions of a vehicle body of the own vehicle;
a control unit prerecorded with image features of detection objects to be detected by the stereo camera:
an image processing unit for performing a pattern matching process to recognize an image feature of a detection object from the image features of the detection objects based on images from the pair of cameras to determine an existence of the detection object:
a distance detecting unit detecting a direction and a distance to the detection object, with the own vehicle being as a reference, from parallaxes of the images from the pair of cameras; and
a warning control unit, when the image processing unit detects the existence of the detection object, selecting a speaker of the plurality of parametric speakers located in the same direction in which the detection object was detected and to control the warning sound to be emitted while adjusting breadth of directivity in accordance with the distance to the detection object,
wherein the warning control unit performs adjusting to widen an angle of the directivity of the selected speaker as the distance to the detection object decreases.

US Pat. No. 10,245,997

RADIO FREQUENCY ID TAG POSITIONING SYSTEM FOR COMPRESSED-GAS TANKS

BAUER COMPRESSORS, INC., ...

1. A radio frequency identification (RFID) tag positioning system, comprising:a collar adapted to be coupled to a filling fixture on a gas tank wherein the filling fixture is aligned with a longitudinal axis of the gas tank; and
a tag holder coupled to said collar, said tag holder being transparent to electromagnetic energy, said tag holder including a first region having a slot extending from an edge of said first region, said tag holder including a second region extending from said first region, said second region including a positioning leg wherein, when said collar with said tag holder coupled thereto is coupled to the filling fixture such that said positioning leg of said tag holder is adapted to be in contact with the gas tank, said slot is approximately perpendicular to the longitudinal axis of the gas tank.

US Pat. No. 10,245,983

OFF-ROAD PERFORMANCE SEAT

Ford Global Technologies ...

1. A seat assembly, comprising:a frame assembly have a seat portion and a seatback portion;
a seat member supported on the seat portion of the frame assembly and having a support portion supported on a carrier member, wherein the support portion and the carrier member of the seat member are comprised of porous non-absorbent materials that are configured to allow water to drain therethrough;
a seatback supported on the seatback portion of the frame assembly and having a support portion supported on a carrier member, wherein the support portion and the carrier member of the seatback are comprised of porous non-absorbent materials that are configured to allow water to drain therethrough; and
a cover member comprised of a perforated fabric that is non-absorbent, wherein the cover member includes a first portion covering the seat member and a second portion covering the seatback.

US Pat. No. 10,245,980

CHILD SAFETY SEAT ASSEMBLY

WONDERLAND SWITZERLAND AG...

1. A child safety seat assembly comprising:a support base having a shell body that defines a receiving area and includes a support surface and an upright surface rising upward from the support surface, the shell body being assembled with a latch located adjacent to the upright surface; and
a child carrier operable to detachably assemble with the support base, the child carrier including a seat shell having a foot portion protruding downward, the foot portion having an opening and an interior in which are assembled a release arm and a fixed rod, the latch of the support base being movable through the opening into the interior of the foot portion for engaging with the rod when the child carrier is installed on the support base;
wherein the foot portion is placed on the support surface in the receiving area and the latch engages with the rod when the child carrier is locked with the support base, and the release arm is operable to push the latch to disengage from the rod for removal of the child carrier from the support base.

US Pat. No. 10,245,971

MOTOR-GENERATOR SYSTEM

Gates Corporation, Denve...

1. A motor-generator system comprising:an internal combustion engine;
a motor-generator in driven engagement with the internal combustion engine by an endless belt, the motor-generator comprising;
a controller detecting a speed signal of the internal combustion engine, a driver input signal, a battery state signal and a motor-generator signal;
the motor-generator operable to provide a motoring torque or a load torque to the internal combustion engine at a predetermined frequency of rotary vibration according to a controller command; and
the controller controlling the motor-generator torque at a frequency greater than 1 Hz such that when the internal combustion engine accelerates, the motoring torque is applied to speed the motor-generator rotation, and when the internal combustion engine decelerates, the load torque is applied to slow motor-generator rotation such that motor-generator rotation is controlled to attenuate a system vibration.

US Pat. No. 10,245,957

SMART REGENERATIVE BRAKING CONTROL

NIO USA, Inc., San Jose,...

1. A method for controlling, via a smart braking system, a speed of a vehicle while a cruise control system of the vehicle is deactivated, comprising:determining, at a first time, that an accelerator of the vehicle is deactivated;
recording a travel speed of the vehicle at the first time;
determining, at a second time, that the vehicle is accelerating while the accelerator is deactivated; and
responsive to determining that the vehicle is accelerating while the accelerator is deactivated, activating a braking system of the vehicle to maintain the speed of the vehicle at the recorded travel speed of the vehicle at the first time.

US Pat. No. 10,245,940

DUAL FUEL TANK FOR LOCOMOTIVE AND MARINE APPLICATIONS

CNGMOTIVE, INC., Frankfo...

1. A dual-fuel railroad locomotive comprising:a chassis;
a plurality of railroad wheels mounted to the chassis;
a dual-fuel diesel cycle engine supported by the chassis and operatively connected to the wheels to drive the wheels to propel the locomotive along a railroad track; and
a dual-fuel tank mounted to the chassis and in fluid communication with the dual-fuel diesel cycle engine, the dual-fuel tank including:
at least one liquid fuel vessel, and
at least one pressurized fuel vessel,
wherein the at least one liquid fuel vessel is positioned to form a side-impact buffer that protects the at least one pressurized fuel vessel from side-impacts.

US Pat. No. 10,245,937

VEHICLE COMPRISING AUTONOMOUS STEERING COLUMN SYSTEM

Carla R. Gillett, Sacram...

1. A vehicle comprising:a frame construction to suit: medical mobility vehicles, robot vehicles, sport vehicles, off road vehicles, vehicles for hire or for ride sharing;
said frame configured with opposing front and rear ends;
one or more seats, said one or more seats configured to support one or more users;
an arrangement of foot pedals or a platform providing footing support;
one or more hub wheels comprising a drive motor, said drive motor including a DC motor type with rotor, stator, gears; or
one or more truck assemblies comprising a drive motor, the drive motor being a DC hub motor type with rotor, stator, and gears;
one or more braking devices,
a platform configured with a contoured construction, and said platform to compartmentalize system components;
a base having an underlying surface characterized by a center of mass to support a user of the vehicle who's either standing or sitting during driving operation;
a seat constructively configured on said base, the seat being configured for user to sit on, or to rest an appendage on;
a powered steering column, pivotally mounted to the front end of the frame, said steering column operatively engaged to propulsion system components;
an array of conduit supporting an array of power cable harnessed within vehicle framework;
one or more fenders;
a control panel affixed to said powered steering column, said control panel comprising a control module including a user I/O interface system;
one or more steering actuators and steering actuator couplings; a retractable locking pin assembly for preventing over rotation;
a handlebar rigidly attached to said steering column, said handlebar being used to turn the steering column both manually or autonomously via said steering actuator;
one or more grip handles situated on said handlebar for user to control power level to throttle and brakes;
one or more thumbwheel switches for user to engage power ON/OFF;
a headlight, a taillight including brake, and turn signal lights;
said powered steering column operatively engaged to a yoke intersection situated on the frame's front end;
a control panel, a power control system connecting to electrical components;
a Lidar sensor and system sensors situated on the vehicle;
one or more cameras having a means to view parameters via a wireless interface communication link, a I/O interface system utilizing local mapping and satellite GPS;
a wireless communication control method to include a Bluetooth communication device for controlling the vehicle motion from afar;
an autonomous control system; the autonomous control system comprising a means for systematically employing short range proximity sensors including LIDAR, and an environmental scanner laser system to detect objects;
a manual drive mode, an autopilot mode, and a semi-autonomous drive mode, an autonomous drive system;
a kickstand mode; an operational control mode, and a balance control mode;
a battery bank, a battery charger, and a wiring connection means furnishing a controlled power source to vehicle system components with one or more charger ports that provide external charging via USB power cable.

US Pat. No. 10,245,936

POWERED SKATEBOARD SYSTEM

Carla R. Gillett, Sacram...

1. A powered skateboard system comprising:a skateboard, said skateboard including:
a deck having a top surface for supporting a rider/operator of the powered skateboard;
a bottom surface configured to facilitate engagement with one or more inner-motorized trucks;
a compartment situated in the bottom surface of the powered skateboard adapted to store one of more control system components and a cover configured to cover an opening formed by said compartment;
said skateboard further comprising a control system, operation sensors, and control devices;
said control system comprising control methodologies configured to monitor and control mechanical operations of said one or more inner-motorized trucks;
said wireless controller device for controlling forward trajectory and braking momentum of said one or more inner-motorized trucks;
a wireless transmitter configured to transmit information associated with the operation of said one or more inner-motorized trucks;
a receiver configured to receive information associated with the operation of said one or more inner-motorized trucks;
a safety mechanism kill switch to shut off power of said one or more inner-motorized truck's drive motors;
one or more wire connections disposed within a conduit array situated between a power control device disposed within said one or more control system components of the powered skateboard system;
one or more battery packs configured for a primary or a secondary back up power source of said powered skateboard system;
a battery charging device and a battery charging controller associated with a charge level of said one or more battery packs used to power said one or more inner-motorized trucks;
one or more motion control devices for controlling the steering and braking operations of said one or more inner-motorized truck drive motors of said powered skateboard.

US Pat. No. 10,245,934

TORQUE ROD AND MANUFACTURING METHOD THEREOF

YAMASHITA RUBBER KABUSHIK...

1. A torque rod comprising:a small ring section to be connected to an engine;
a large ring section to be connected to a vehicle body;
a rod section providing a connection between the small ring section and the large ring section;
the small ring section including an outer member connected to the rod section, a small ring inner member to be connected to the engine, and a small ring elastic member providing a connection between the outer member and the small ring inner member, said small rind elastic member of the small rind providing a small rind torsion spring, which is generated by torsion applied to the small rind elastic member, when vibration of the engine is transmitted through the small rind section to the rod section; and
the large ring section including an outer member connected to the rod section, an inner member to be connected to the vehicle body, and a large ring elastic member providing a connection between the outer member and the inner member, said large rind elastic member of the large rind section providing a large rind spring, which is generated by transmission of vibration from the rod section to the vehicle body side, said large ring spring including a first spring in an axial direction of the rod section and a second spring in an axial direction of the inner member;
the torque rod produces a rigid body resonance due to vibration of the engine and transmits the vibration to the vehicle body,
wherein transmission characteristics relative to a magnitude of transmission force transmitted from the large ring section to the vehicle body at a time of rigid body resonance of the torque rod, are such that a capacity of transmission force from the large ring section to the vehicle body at a resonance peak is less than 100N/mm,
wherein transmission characteristic parameters for realizing the transmission characteristic of the torque rod include: the small ring torsion spring and a large ring spring ratio, which is a ratio the first spring to the second spring, when the vibration is transmitted from the rod section to the vehicle body.

US Pat. No. 10,245,931

SEAL ASSEMBLY AND THE ASSEMBLING METHOD THEREOF

TAIZHOU VALEO WENLING AUT...

1. A seal assembly for sealing connection region between a glass and a shaft assembly passing through the glass, said shaft assembly comprising a shaft and a threaded bushing around the shaft, the seal assembly comprising:an outer seal, having a body portion used to be supported on the glass, the outer seal further comprising at least one first sealing portion to form at least one sealing area;
an inner rotatable seal, having a body portion with a thread for engaging a thread of the bushing, the inner rotatable seal further comprising at least one second sealing portion to form at least one sealing area,
wherein the body portion of the outer seal and the body portion of the inner rotatable seal each has corresponding threads for engaging the outer seal with the inner rotatable seal,
wherein the thread on the body portion of the outer seal is an external thread, and the thread on the body portion of the inner rotatable seal is an internal thread.

US Pat. No. 10,245,929

LOCKING DEVICE HAVING A LOCKING HOOK AND A MOVABLE SLIDE

WEBASTO SE, Stockdorf (D...

1. A locking device of a top of a convertible vehicle, comprising a locking support, a locking hook, which can be shifted in at least one of a translational and rotational manner so as to be displaced between a release position and a locked position, and a driving mechanism for the locking hook, said driving mechanism comprising a driving wheel, which is driven by a driving motor and which drives a slide movable on the locking support, wherein the slide is connected to a driving section of the locking hook via a pull-link arrangement in such a manner that the locking hook undergoes a pivoting movement when the slide is moved.

US Pat. No. 10,245,927

METHOD AND APPARATUS FOR A TARPAULIN FASTENING SYSTEM

Royer Ent., LLC, Payson,...

1. A tarp fastening system, comprising:a flatbed trailer, including
at least one mechanical support structure;
a rubrail;
a payload; and
a tarp arranged to cover the payload; and
one or more tarp fastening devices removably coupled to the at least one mechanical support structure, each of the one or more tarp fastening devices including,
a support frame;
a spool coupled to the support frame;
an interconnecting line cord coupled to the spool;
a plurality of connection pins coupled to the interconnecting line cord; and
a gear assembly coupled to the spool, wherein the plurality of connection pins are removably coupled to the tarp and the rubrail and the gear assembly is configured to retract the interconnecting line cord into the spool to secure the tarp to the payload.

US Pat. No. 10,245,910

AUXILIARY FIXTURE FOR A TIRE PRESSURE MONITORING DEVICE

ORANGE ELECTRONIC CO., LT...

1. An auxiliary fixture for a tire pressure monitoring device comprising:a handle;
a positioning base connected to the handle and having
a rear side;
a front side;
a pivot segment deposited on the rear side of the positioning base and connected to the handle;
a clamping segment deposited on the front side of the positioning base, and having a pushing pin deposited on the clamping segment to press against the tire pressure monitoring device to enable a valve stem of the tire pressure monitoring device to insert into a valve hole of a tire rim; and
a quick release structure mounted between the pivot segment and the clamping segment to connect the clamping segment with the pivot segment; and
a holding lever connected to the handle.

US Pat. No. 10,245,890

TIRE WITH NOISE-REDUCING TREAD PATTERN

Bridgestone Americas Tire...

1. A tire having an axis of rotation, said tire comprising:a tread extending circumferentially about said axis and including a plurality of tread elements disposed in a tread pattern,
each of said plurality of tread elements having one of two different pitch lengths, the two different pitch lengths being a short pitch length and a long pitch length, a pitch ratio of the long pitch length to the short pitch length being within a range of from approximately 1.15 to approximately 1.40, and
said tread pattern including 44 pitches having 24 occurrences of a first pitch length and 20 occurrences of a second pitch length arranged according to a pitch sequence of 2 1 2 2 2 2 2 1 2 2 1 1 1 1 1 1 1 2 2 2 2 2 2 1 1 1 1 1 1 2 2 2 2 1 2 1 1 1 1 1 1 2 1 1 wherein in the pitch sequence, 1 is a pitch having the short pitch length and 2 is a pitch having the long pitch length.

US Pat. No. 10,245,883

FOLDABLE WHEEL

BAGOLF LIMITED, Hong Kon...

1. A foldable wheel defined about an axis of rotation of the wheel, the foldable wheel comprising a closed loop having at least two consecutive links, each consecutive link being substantially in the form of a ring sector of section as defined in a plane that is substantially perpendicular to said axis of rotation of the wheel that presents substantially the shape of a trapezoid, thus comprising two non-parallel faces, a major base, and a minor base, means for mounting two consecutive links to pivot relative to each other about a link pivot axis, the facing two non-parallel faces belonging respectively to two consecutive links being defined in such a manner that, when they are not in contact with each other, they form a V-shape of apex directed towards the two major bases, the V-shape having an angle at the apex of value that is not zero, and when they are in contact with each other, they form a V-shape with an angle at the apex of zero value, said link pivot axis being situated substantially at the apex of a said V-shape and being parallel to said axis of rotation of the wheel, wherein the means for mounting two said consecutive links to pivot relative to each other are constituted by:a bearing comprising two portions, respectively a male bearing portion forming a pivot pin on the link pivot axis and a female bearing portion forming a pivot housing, said pivot pin being pivotally mounted in said pivot housing; and
means for mounting said male and female bearing portions respectively at two points belonging respectively to two consecutive links and situated in the proximity of the apex of said V-shape.

US Pat. No. 10,245,880

PRESS PLATE OR ENDLESS BELT WITH RFID TRANSPONDER

HUECK Rheinische GmbH, V...

1. Press plate or endless belt, comprising a flat body with a stamping surface and at least one external surface which is provided not for stamping,wherein the press plate or endless belt has at least one RFID transponder, and the RFID transponder is equipped with an electronic memory which can be read and written to by the RFID transponder, and at least one data record identifying the press plate or endless belt is stored in the memory.

US Pat. No. 10,245,878

TABLET WITH INTERCONNECTION FEATURES

COMSERO, INC., Broomfiel...

1. A process of using, arranging, and rearranging a plurality of tablet assemblies comprising:providing a first tablet including an upper surface, a bottom surface, a first side comprising a first magnet, a second side comprising a second magnet, a third side comprising a third magnet, and a fourth side comprising a fourth magnet;
providing a second tablet including an upper surface, a bottom surface, a first side comprising a first magnet, a second side comprising a second magnet, a third side comprising a third magnet, and a fourth side comprising a fourth magnet;
providing a first mounting assembly comprising ferrous metal including a first leg with a first rivet, a second leg with a second rivet, a third leg with a third rivet,
and a fourth leg with a fourth rivet;
providing a second mounting assembly comprising ferrous metal including a first leg with a first rivet, a second
leg with a second rivet, a third leg with a third rivet, and a fourth leg with a fourth rivet;
releasably interconnecting the first tablet to the first mounting assembly by interconnecting the first magnet of the first tablet to the first rivet of the first mounting assembly, interconnecting the second magnet of the first tablet to the second rivet of the first mounting assembly, interconnecting the third magnet of the first tablet to the third rivet of the first mounting assembly, and
interconnecting the fourth magnet of the first tablet to the fourth rivet of the first mounting assembly; and
releasably interconnecting the second tablet to the second mounting assembly by interconnecting the first magnet of the second tablet to the first rivet of the second mounting assembly, interconnecting the second magnet of the second tablet to the second rivet of the second mounting assembly, interconnecting the third magnet of the second tablet to the third rivet of the second mounting assembly, and interconnecting the fourth magnet of the second tablet to the fourth rivet of the second mounting assembly;
wherein the first leg of the first mounting assembly comprises a first protuberance, the second leg of the first mounting assembly comprises a first indention, the third leg of the first mounting assembly comprises a second protuberance, and the fourth leg of the first mounting assembly comprises a second indention, and wherein the first leg of the second mounting assembly comprises a first indention to receive the first protuberance of the first mounting assembly, the second leg of the second mounting assembly comprises a first protuberance which is received by the first indention of the first mounting assembly, the third leg of the second mounting assembly comprises a second indention to receive the second protuberance of the first mounting assembly, and the fourth leg of the first mounting assembly comprises a second protuberance which is received by the second indention of the first mounting assembly.

US Pat. No. 10,245,874

LAY-FLAT BOOK PRODUCTION

HP Indigo B.V., Amstelve...

1. A lay-flat book block production apparatus comprising:a glue dispenser to transition between an active state in which glue is provided to one side of a web that is guided past the glue dispenser, and an inactive state in which glue is not provided to the web that is guided past the glue dispenser; and
a folding unit to fold the web, wherein each of a plurality of flat portions of a side of the folded web faces another of the plurality of flat portions of a same side, and wherein the folding unit includes a roller pair to guide the web and provide the web with a plurality of crease lines and a plurality of perforation lines, wherein:
a first roller of the roller pair includes at least one longitudinally extending, radially protruding portion to dive into at least one corresponding longitudinally extending notch of a second roller of the roller pair to crease the web, wherein the at least one corresponding longitudinally extending notch forces the web to sharply bend around the at least one longitudinally extending, radially protruding portion, and
the second roller of the roller pair includes at least one longitudinally extending line of radially protruding pins to dive into at least one longitudinally extending line of recesses of the first roller of the roller pair to perforate the web.

US Pat. No. 10,245,868

IMAGE TRANSFER MATERIAL AND POLYMER COMPOSITION

MJ SOLUTIONS GMBH, Plymo...

1. An image transfer sheet for transferring an image to a receptor element, the image transfer sheet comprising:a melt transfer layer;
an image receiving layer; and
a first opaque layer positioned between the melt transfer layer and the image receiving layer, the first opaque layer comprising a thermoplastic elastomer and a white pigment; and
a second opaque layer positioned between the melt transfer layer and the image receiving layer, the second opaque layer comprising a thermoplastic elastomer and a white pigment;
wherein the combined thickness of the first and second opaque layers is between 0.5 to 2.5 mils; and
wherein the second opaque layer has a composition different from a composition of the first opaque layer.

US Pat. No. 10,245,849

VAPOR CONTROL HEATING IN A PRINTER

Hewlett-Packard Developme...

1. A vapor control heater for a printer having a dryer to dry a print substrate leaving a print zone, comprising:a housing;
a heating element at least partially enclosed by the housing; and
a fan to move air over the heating element and into an air flow from the dryer after the air flow passes over the print substrate.

US Pat. No. 10,245,838

LIQUID EJECTING APPARATUS

Seiko Epson Corporation, ...

1. A liquid ejecting apparatus, comprising:a liquid ejecting head ejecting liquid onto a medium transported on a transport path extending in a depth direction;
a carriage holding the liquid ejecting head and reciprocally moving in a width direction so as to cross the transport path; and
a waste liquid containing portion containing waste liquid discharged from the liquid ejecting head, wherein
the carriage includes a plurality of liquid containers that contain the liquid and are mounted on the carriage in such a manner that the plurality of the liquid containers are arranged side by side with each other in the depth direction, and
a portion of the carriage overlaps the waste liquid containing portion in a vertical direction when the liquid ejecting head is outside the transport path.

US Pat. No. 10,245,824

METHOD FOR DECORATING THE SIDES OF PLASTIC CARDS

Smart Layer 3, S.L., Bar...

1. A method for decorating sides of plastic cards by hot foil stamping, the method comprising the following steps:a. placing a plurality of plastic cards on a support wedge, such that first sides of said plastic cards are opposite an engraver,
b. hot foil stamping, via the engraver, the first sides of the plastic cards and including round corners formed by said first sides with adjacent sides of the cards,
c. blowing air on the hot foil stamping applied to the first sides,
d. placing the plurality of plastic cards on the support wedge such that second sides of said plastic cards are opposite the engraver,
e. hot foil stamping, via the engraver, the second sides of the plastic cards and including round corners formed by said second sides with adjacent sides of the cards,
f. blowing air on the hot foil stamping applied to the second sides,
g. placing the plurality of plastic cards on the support wedge, such that a third side of said plastic cards are opposite the engraver,
h. hot foil stamping, via the engraver, the third sides of the plastic cards and including round corners formed by said third sides with adjacent sides of the cards,
i. blowing air on the hot foil stamping applied to the third sides,
j. placing the plurality of plastic cards on the support wedge, such that fourth sides of said plastic cards are opposite the engraver,
k. hot foil stamping, via the engraver, the fourth sides of the plastic cards and including round corners formed by said fourth sides with adjacent sides of the cards, and
l. blowing air on the hot foil stamping applied to the fourth sides.

US Pat. No. 10,245,820

FORMING SACRIFICIAL STRUCTURES USING PHASE-CHANGE MATERIALS THAT SUBLIMATE

PALO ALTO RESEARCH CENTER...

1. A method, comprising:depositing a first layer of a polymer material;
depositing a first amount of sublimable material on the first layer of the polymer material to form a first sacrificial structure, wherein the sublimable material includes cyclododecane;
depositing a second layer of the polymer material on the first amount of sublimable material and first layer of the polymer material; and
removing the sublimable material to form a channel defined by the first and second layers of the polymer material.

US Pat. No. 10,245,808

MULTI-LAYERED FUNCTIONAL FABRIC AND ARTICLES

Halo International SEZC L...

1. A laminated fabric article comprising:a first layer of shock absorbing visco-elastic fabric;
a second layer of electromagnetic barrier metallized fabric; and
a third layer of moisture barrier hydrophobic coated fabric;
wherein the second layer and the third layer have unstrained areas larger than an unstrained area of the first layer, and are substantially delaminated from the first layer except at their edges.

US Pat. No. 10,245,800

WASTE PAPER REBALER

Sonoco Development, Inc.,...

1. A method of rebating lower density bales of waste paper to form higher density bales, the method comprising the steps of:using a fork lift truck to retrieve two strapped lower density bales from a remote location and delivering them to a loading platform of a rebaler;
pushing with forks of the fork lift truck one of the lower density bales through a rectangular feed port and into a breach of a rebaler housing;
pushing with the forks of the fork lift truck the other lower density bale through the rectangular feed port and into the breach of the rebaler housing so that the bales are in side-by-side relationship with respect to one another, the rebaler housing being formed of vertical side walls and a vertical end wall joined by horizontal top and bottom walls and defining an interior space having a downstream end proximate the vertical end wall, an upstream end opposite the downstream end, and a width defined by a distance between the vertical side walls, with the breach being defined at the upstream end of the interior space, the rectangular feed port being formed in one of the vertical side walls adjacent to and in communication with the breach, and with the long axes of the bales extending across the width of the interior space;
progressively moving a compression ram from the upstream end toward the downstream end to first push the two strapped lower density bales from the breach and into a compression chamber defined at the downstream end of the interior space, and then to compress the two lower density bales together against the vertical end wall to form a higher density bale;
binding the higher density bale to maintain the bale in its compressed configuration;
ejecting the higher density bale through a rectangular ejection port formed into one of the vertical sidewalls of the housing and onto a retrieval platform located beneath and outboard of the ejection port; and
retrieving with the fork lift truck the higher density bale from the retrieval platform.

US Pat. No. 10,245,797

METHOD, PROCESS AND APPARATUS FOR MANUFACTURING TYRES FOR VEHICLE WHEELS

PIRELLI TYRE S.p.A., Mil...

1. A process for building tyres for vehicle wheels, the process comprising: forming all components belonging to a carcass sleeve of a first tyre on a first forming drum and all components belonging to a carcass sleeve of a second tyre on a subsequent second forming drum, wherein said tyre components belonging to a carcass sleeve of said first and second tyres are formed by:loading the first forming drum at a loading and unloading location of a carcass-building line, on a single shuttle movable along a straight guide;
moving the shuttle on the straight guide to bring said shuttle to a plurality of dispensing stations of semifinished products, wherein each dispensing station is disposed in a respective deposition location, and each respective deposition location is included in a plurality of deposition locations positioned in a space succession along the straight guide, wherein at each of said dispensing stations of semifinished products, a semifinished product is laid on a radially external surface of the first forming drum carried by the shuttle for forming one of the components belonging to the carcass sleeve of the first tyre; and
bringing the first forming drum provided with the components formed by the dispensing stations back to said loading and unloading location and unloading said first forming drum from said shuttle before loading the subsequent second forming drum,
shifting the unloaded first forming drum provided with the components formed by the dispensing stations to an apparatus at which annular anchoring structures of the first tyre are placed and turned up portions of the carcass sleeve of the first tyre are formed, then carrying the first forming drum to an apparatus at which the turned-up portions are rolled, and then to an assembling station at which an outer sleeve is coupled to the carcass sleeve of the first tyre
wherein the first forming drum is moved in a first sequence among a first set selected from the plurality of deposition locations, the first sequence being different from the space succession of said deposition locations along the straight guide and wherein the first forming drum is brought at least two times to one and the same deposition location of the first set;
wherein the subsequent second forming drum is moved in a second sequence among a second set selected from the plurality of deposition locations and wherein the subsequent second forming drum is brought at least two times to one and the same deposition location of the second set, the number of deposition locations of the first set being different than the number of deposition locations of the second set,
wherein the space succession of the plurality of deposition locations remains unchanged,
wherein only a single forming drum is located on and moved along the straight guide at a time between the times of loading and unloading that single forming drum on and from said shuttle, and the shuttle holds the single forming drum during the laying of the semifinished products; and
wherein a running direction of said shuttle is reversed at least twice after the loading of the single forming drum onto said shuttle and before said shuttle is further reversed to return to the loading and unloading location during movement of said shuttle along the straight guide while forming components of each carcass sleeve of the first and second tyres.

US Pat. No. 10,245,790

METHOD FOR PRODUCING A COMPONENT CONNECTION

Bayerische Motoren Werke ...

1. A method for producing a component connection, the method comprising the acts of:providing a first component which is made of a thermoplastic plastic material at least in the region of a part of its surface;
providing a ball which is made of a thermoplastic plastic material at least in a region of its surface;
pressing the ball onto the first component such that the thermoplastic plastic material of the ball bears against the thermoplastic plastic material of the first component;
vibrating the ball via an ultrasonic sonotrode and welding the ball to the first component;
providing a second component which has a through-hole;
bringing the second component up to the first component such that the ball projects at least into the through-hole of the second component or projects to a certain extent through the through-hole; and
clipping a clip element onto the ball, wherein the clip element projects beyond the through-hole and interconnects the two components in an interlocking and/or force-locking manner.

US Pat. No. 10,245,787

THREE-DIMENSIONAL PRINTING APPARATUS AND THREE-DIMENSIONAL OBJECT PRINTING METHOD

ROLAND DG CORPORATION, S...

1. A three-dimensional printing apparatus that cures liquid photo-curable resin to sequentially stack resin layers each having a predetermined cross-sectional shape to print a three-dimensional object, the apparatus comprising:a tank storing the liquid photo-curable resin and including a printing region in which the three-dimensional object is to be printed;
a projector to project a first image having a quadrangular or substantially quadrangular shape onto the tank; and
a controller to control the projector; wherein
the controller includes:
a matrix calculator to calculate a projective transformation matrix by which the first image is projectively transformed so that the first image is presented on an entirety of the printing region;
an acquirer to transform the first image using the projective transformation matrix, thus acquiring a second image obtained by correction of the first image, the second image including a projection sub-image having a quadrangular or substantially quadrangular shape;
an inclination calculator to calculate a horizontal inclination and a vertical inclination of the projection sub-image in the second image;
a vertical and horizontal correction value calculator to calculate, based on the horizontal inclination, a first correction value by which a horizontal brightness distribution of the first image is corrected, and to calculate, based on the vertical inclination, a second correction value by which a vertical brightness distribution of the first image is corrected;
a memory to store a third correction value by which a brightness distribution of the first image projected onto the entirety of the printing region is corrected, the first image projected having a rectangular, substantially rectangular, square or substantially square shape;
a corrector to correct a brightness distribution of the second image using a fourth correction value calculated based on the first correction value, the second correction value, and the third correction value; and
a projection controller to control the projector so that the projection sub-image of the second image whose brightness distribution has been corrected is projected from the projector onto the tank.

US Pat. No. 10,245,777

GUSSET BOARD WITH COLLAPSIBLE NOSE

Pearl Technologies, Inc.,...

1. A gusset board configured to fold a gusset in a tube of film, the gusset board comprising:a base portion of the gusset board;
a base sliding surface on the base portion, the base sliding surface being fixed stationary on the gusset board;
a nose portion of the gusset board;
a nose sliding surface on the nose portion of the gusset board, the nose sliding surface is positioned in substantially a same plane as the base sliding surface, the nose sliding surface having a general triangular configuration with a base edge and an opposite apex end;
the nose portion of the gusset board having a rear surface on an opposite side of the nose portion of the gusset board from the nose sliding surface; and,
a mast having a length with opposite proximal and distal ends, the proximal end of the mast being connected to the rear surface of the nose portion of the gusset board at the apex end of the nose sliding surface, the mast being configured to be moved between a first position of the mast relative to the rear surface of the nose portion of the gusset board where the mast extends outwardly from the rear surface of the nose portion of the gusset board and a second position of the mast relative to the rear surface of the nose portion of the gusset board where the mast extends along the rear surface of the nose portion of the gusset board.

US Pat. No. 10,245,773

METHOD FOR MOLDING TWO-PIECE BLOW MOLDED HOLLOW TANK BY USING AUXILIARY MALE MOLDS

YAPP AUTOMOTIVE PARTS CO....

1. A method for blow molding a hollow tank formed by two parisons by using auxiliary male molds, wherein the method comprises the following steps:1) positioning the two parisons of the tank to be blow-molded into a mold, the mold comprising two half molds and a pre-molding template between the two half-molds, wherein the two parisons of the tank to be blow-molded are positioned between the two half molds and the pre-molding template respectively;
2) closing the two half molds of the mold onto the pre-molding template;
3) pre-stretching the molten parisons by using the auxiliary male molds provided on the pre-molding template;
4) performing high-pressure blow molding inside the mold to melt the two parisons, and pre-molding the molten parisons into two housing pieces;
5) opening the mold, and withdrawing the pre-molding template;
6) moving into the mold a device for facilitating inside components of the hollow tank to be connected to the pre-molded housing pieces;
7) moving the device out from the mold;
8) closing the mold for the second time and finishing blow molding the hollow tank; and
9) opening the mold and taking out the molded hollow tank;
wherein the auxiliary male molds provided on the pre-molding template are set as a split-type structure, and
wherein step 3) further comprises a specific step of as follows:
3-1) after the two half molds of the mold are closed, the parisons are sucked into the mold by vacuum force, and at the same time an actuating mechanism drives the auxiliary male molds to move toward an inner wall of the mold, so as to perform pre-stretching on the parisons; and
wherein in the step 6, a robot moves the device together with the inside components to a location that is between the two half mold and
where the connection of the inside component to the pre-molded housing pieces shall be performed.

US Pat. No. 10,245,763

METHOD FOR THE PRODUCTION OF SOLID SURFACES FOR CONSTRUCTION

COSENTINO RESEARCH AND DE...

1. A method for the production of a board made from materials for construction comprising the following steps:a) storing raw materials that are inorganic,
b) controlled metering different ones of the raw materials,
c) dry milling or wet milling the raw materials from the controlled metering of step b) to obtain a first mixture,
d) storing the first mixture obtained in step c),
e) processing and adding color pigments to a proportion of the first mixture stored in d), obtaining a first colored mixture,
f) mixing at least some of the first mixture with the first colored mixture obtained in step e) to obtain a homogenous colored mixture,
g) storing different homogenous colored mixtures obtained from steps a) through f) using different color pigments,
h) creating a blanket of different homogenous colored mixtures by metering the different homogenous colored mixtures on a conveyor belt to create different embellishments throughout an entire volume of the blanket or throughout at least a portion of an entire volume or a surface of the blanket in a non-homogenous manner, wherein the application of different embellishments comprises controlled distribution onto a conveyor of the different homogenous colored mixtures in order to obtain a desired aesthetic design,
i) subsequent to step h), compacting the different homogenous colored mixtures at a compaction pressure to form a compacted board,
j) sizing an end part of each compacted board by cutting through an entire thickness of the compacted board,
k) pressing the compacted board at a pressure greater than the compaction pressure to form the board for construction,
l) drying the pressed board,
m) subsequent to drying the pressed board, cooking the pressed board, and
n) calibrating, polishing, cutting or beveling edges of the cooked pressed board.

US Pat. No. 10,245,759

MOULDING MACHINE AND PROCESS FOR FORMING A MOULD

UPCYCLE HOLDINGS LIMITED,...

1. A moulding machine comprising first and second non-complementary moulds, the first mould defining a female mould cavity and the second mould defining a flat moulding surface, wherein the first and second moulds are movable between a first position in which the moulds are apart and the female mould cavity and the flat moulding surface both face upwards, and a second position in which the moulds are brought together and the flat moulding surface faces into and closes the female mould cavity to form a completely enclosed cavity, and wherein each mould has a plurality of bores formed through it with an opening at each end configured for receiving flow of a mould cooling or heating fluid, and at least two of the bores are connected to each other by a block over the opening at one end of one bore and the opening at the end of another bore, the block having a mould facing surface and being formed with a groove defined on the mould facing surface which connects the openings to each other, wherein the or each groove is formed with a first end, a second end, and a constriction therebetween such that the flow path of the or each groove first narrows and then widens again between the first end and the second end, the constriction being configured to provide a venturi effect so that when the fluid passes through the constriction its velocity increases.

US Pat. No. 10,245,757

MOLD EXTRACTOR ASSEMBLY FOR CONCRETE PRODUCTS FORMING MACHINE

COLUMBIA MACHINE, INC., ...

1. A mold extractor configured to move a mold assembly to and from a mounted position within a concrete products forming machine (CPM), the mold extractor comprising:in a concrete products machine, a mold mounting structure in a CPM center section and a feed drawer assembly located to a rear of the CPM center section;
a lift mechanism coupled to the feed drawer assembly configured to vertically move the feed drawer assembly with respect to the mold mounting structure;
a guide rail assembly coupled to an underside of and vertically moveable with the feed drawer assembly via the lift mechanism;
an extractor arm assembly moveable horizontally along the guide rail assembly via a first extension assembly coupled to the extractor arm assembly;
an extractor fork assembly telescopically nested about the extractor arm assembly; and
a second extension assembly, independent of the first extension assembly, coupled between the extractor arm assembly and the extractor fork assembly and configured to extend a horizontal reach of the mold extractor forwardly of the mold mounting structure, wherein the lift mechanism and first and second extension assemblies are operative to extend the extractor fork to an intermediate extended position just below the mold mounting structure, lift the extractor fork up against a mold resting on the mold mounting structure so that the mold is carried off the mold mounting structure, moving the mold forwardly to an extended position at a mold transfer assembly, and lowering the mold onto the mold transfer assembly.

US Pat. No. 10,245,756

MOLD ASSEMBLY FOR CONCRETE PRODUCTS FORMING MACHINE

COLUMBIA MACHINE, INC., ...

1. A mold assembly for forming concrete products comprising:a mold box having cavities disposed between side walls of the mold box for receiving and molding concrete products;
a head assembly having multiple shoes aligned within the mold box cavities and slots formed on outside upper surfaces thereof;
compression strip stop brackets slidably received in each of the slots to enable tool less insertion and removal of the compression strip stop brackets from the head assembly and configured to contact stop block surfaces on the concrete products forming machine during a product forming process;
a mounting bracket extension coupled to each of the side walls of the mold box and forming a lower mounting surface of the mold assembly configured to mount to shelves of a concrete products forming machine;
die alignment holes formed in an underside of each mounting bracket extension and configured to receive alignment dowels extending upward from shelves of the concrete products forming machine;
mold transfer locators formed in an underside of each of the sidewalls inward of the die alignment holes and shelves of the concrete products forming machine and configured to locate the mold assembly onto mold extractor arms when the mold assembly is lifted off of the alignment dowels by the mold extractor arms during a mold extraction process.

US Pat. No. 10,245,751

CLAMPING ASSEMBLY FOR WOODWORKING KNIFE

ANDRITZ IGGESUND TOOLS AB...

1. A clamping assembly for clamping at least one or more knife elements onto a base member of a woodworking machine, said one or more knife elements having first and second opposed sides; said clamping assembly comprising:first and second clamping, components securing said one or more knife elements therebetween, said first clamping component abutting said second clamping component at least at one location;
said first clamping component having two ends and first and second opposed sides and being sized and shaped to have three distinct contact positions, said distinct contact positions comprising, (1) a surface defining a fulcrum located generally adjacent one end of the first clamping component, (2) a surface defining a knife abutting portion, located generally adjacent the other end of the first clamping component, abutting the first side of said one or more knife elements, and (3) a bearing surface, all such surfaces at said three contact positions being located on the same first side of the first clamping component, with the bearing surface located between the fulcrum and the knife abutting portion of the first clamping component;
said second clamping component having: i) two ends and first and second opposed sides, ii) a bearing support surface formed on the first side of the second clamping component and being sized, shaped and oriented, such that it engages the bearing surface of the first clamping component and iii) a surface portion also on the first side of the second clamping component sized, shaped and oriented such that it engages the second opposite side of said one or more knife elements;
said first and second clamping components having openings formed therein extending between the clamping components' respective first and second sides and located between their respective ends, said opening, in the first clamping component being located intermediate of the knife abutting portion and the fulcrum, and said openings being in alignment with each other;
an actuator applying a clamping force to said first clamping component along a clamping axis defined by the aligned openings in the clamping components, said actuator having a head engaging the second side of the first clamping component and a threaded shank extending from the head through the aligned openings in said damping components to secure said clamping components on the base member, whereby the clamping force is directed by said first clamping component against the first side of said one or more knife elements at the knife abutting portion and at said fulcrum toward the second clamping component;
i) said surface defining the fulcrum of the first clamping component, ii) said surface defining the knife abutting portion of the first clamping component and iii) said surface portion of the second clamping component engaging the second opposite side of said on or more knife elements all lying on planes being generally parallel to each other and all inclined relative to the clamping axis and transverse to it whereby the first clamping component is caused to slide relative to the second clamping component under the action of the clamping force;
said surface defining the fulcrum of the first clamping component also being formed as a substantially planar surface which is oriented relative to the clamping axis such that a line normal to said substantially planar surface is at an acute angle ? to said clamping axis;
said bearing surface of the first clamping component and said bearing support surface of the second clamping component being located facing each other parallel to said clamping axis and being sized, shaped, oriented, and positioned to not bear the clamping force such that a line normal to said bearing surface and said bearing support intersects said line normal to the surface of said fulcrum at a location farther askew of said clamping axis than said fulcrum whereby said bearing surface and the bearing support surface resist sliding movement of said first clamping component under the action of the clamping force and a reaction force developed at the fulcrum under the action of the clamping force has a line of action directed away from the clamping axis.

US Pat. No. 10,245,746

STOCK GUIDE ASSEMBLY

JessEm Products Limited, ...

1. A stock guide assembly for use with a work table to guide movement of stock along a work surface of the work table in a feed direction, the stock guide assembly comprising:a base configured for mounting the stock guide assembly on the work table;
a shaft having a shaft axis and first and second end portions spaced apart along the shaft axis, the shaft mounted on the base for selectively moving along and pivoting about the shaft axis with respect to the base;
an arm having an arm axis oriented transverse to the shaft axis and first and second end portions spaced apart along the arm axis, the arm having a first arm member defining the first end portion and a second arm member defining the second end portion, the first and second arm members being selectively attachable to one another to selectively adjust a distance between the first and second end portions, the first end portion of the arm being attached to the second end portion of the shaft to constrain the arm for moving relative to the base conjointly with the shaft;
a roller mounted on the second end portion of the arm for rotation relative to the arm and for moving relative to the base conjointly with the arm and the shaft, the shaft being selectively movable relative to the base when the base is mounted on the work table to position the roller for engaging stock passing by the base to hold the stock against the work table;
a clamping assembly pivotably supported on the base for pivoting with respect to the base about the shaft axis in first and second pivot directions within a range of motion having a first end position and a second end position, the clamping assembly configured to be selectively connected to the shaft to inhibit movement of the shaft with respect to the base along the shaft axis and to constrain the shaft to pivot with the clamping assembly about the shaft axis with respect to the base within the range of motion, the clamping assembly comprising:
a pivot bracket having a first end portion and a second end portion and arranged relative to the base so that the first end portion engages the base when the clamping assembly is positioned at the first end position to inhibit movement of the clamping assembly from the first end position in the first pivot direction and so that the second end portion engages the base when the clamping assembly is positioned at the second end position to inhibit movement of the clamping assembly from the second end position in the second pivot direction; and
a clamping jaw connected to the pivot bracket for selectively gripping the shaft between the pivot bracket and the clamping jaw to connect the shaft to the clamping assembly; and
a biasing assembly operatively connected between the base and the clamping assembly to yieldably bias the clamping assembly relative to the base in the first pivot direction, the biasing assembly comprising:
a spring holder attached to the base; and
a spring operatively connected to the spring holder and the pivot bracket to yieldably bias the pivot bracket in the first pivot direction;
wherein when the shaft is connected to the clamping assembly and the base mounts the stock guide assembly on the work table,
wherein the biasing of the pivot bracket in the first pivot direction biases the roller in the first pivot direction toward engagement with the stock passing by the base through the connection between the clamping assembly and the shaft, and
wherein movement of the roller in a direction away from the work surface pivots the arm, the shaft, and the clamping assembly in the second pivot direction relative to the base and the spring holder against the yieldable biasing force imparted by the compression spring until the second end portion of the pivot bracket engages the base at the second end position of the range of motion of the clamping assembly to inhibit further movement of the roller away from the work surface.

US Pat. No. 10,245,744

ACCESSORY FOR OSCILLATING POWER TOOLS

Cherif Morcos, Kirkland,...

1. A blade accessory for use with an oscillating power tool, the blade accessory comprising:a body extending in a longitudinal direction from a first end to a second end, the first end being a blade end for cutting, the second end being an attachment end for mounting the blade accessory to the oscillating power tool;
an arbor defined at the attachment end of the body, the arbor being configured to matingly engage attachment elements of a drive flange of the oscillating power tool, the arbor comprising a plurality of openings including:
a primary opening comprising:
a central opening defining a central axis of the arbor;
a first elongated opening conjoined with the central opening and extending radially from the central axis along a first radial axis;
a second elongated opening conjoined with the central opening and extending radially from the central axis along a second radial axis, wherein said second radial axis is substantially orthogonal to said first radial axis;
wherein the first elongated opening and the second elongated opening each extend radially to a first specific radial distance measured from the central axis of the arbor; and
a set of secondary openings disjoined from said primary opening and positioned radially about the central axis along respective radial axes distinct from said first and second radial axes, the secondary openings in the set of secondary openings extending to a second specific radial distance measured from the central axis of the arbor, wherein the second specific radial distance to which the secondary openings extend is the same as the first specific radial distance to which the first and second elongated openings extend.

US Pat. No. 10,245,739

SHAVER

DORCO CO., LTD., Seoul (...

1. A shaver comprising:a cartridge including:
a cartridge body;
a plurality of blades installed in the cartridge body along an elongated direction of the cartridge body, wherein a rear portion of each of the blades is generally straight;
a plurality of pairs of side fixation slots, each pair of the side fixation slots formed on left and right frame portions of the cartridge body, respectively, so as to fix left and right lateral ends of each corresponding blade;
a supporter provided at a center area between the left and right frame portions of the cartridge body and connecting upper and lower frame portions of the cartridge body, wherein the supporter has a rear surface;
a plurality of inside fixation slots, each formed on the supporter provided at the center area so as to fix the rear portion of each corresponding blade; and
a hinge portion formed on either end of the lower frame portion of the cartridge body, the hinge portion having a hinge groove; and
a handle body coupled to the cartridge body, the handle body including:
a hinge protrusion being coupled to the hinge groove; and
an elastic portion projecting from an upper portion of the handle body, the elastic portion contacted with the rear surface of the supporter so that a swing operation of the cartridge body via the hinge protrusion being coupled to the hinge groove is elastically performed by an elastic force of the elastic portion,
wherein the hinge protrusion extends outwardly in a lateral direction.

US Pat. No. 10,245,736

AUTOMATICALLY RETRACTABLE CUTTER

ORANGE HARDWARE COMPANY, ...

1. A cutter comprising:a handle comprising a slot in an end of the handle and two grooves in two opposite internal faces of the handle;
a cassette comprising:
a first pair of bosses inserted in the grooves to allow the cassette to translate and pivot in the handle; and
a catch formed on the cassette;
a blade partially inserted in the cassette;
a sliding element formed with a fin, and movably inserted in the handle between a rear position where the fin is separated from the catch and a front position where the fin is in contact with the catch and the cassette is located closer to the slot than when the sliding element is in the rear position, wherein the catch is abutted against the fin so that the cassette is moved forwards in the handle by the sliding element during movement to the front position from the rear position;
a spring for connecting the sliding element to the handle, thereby biasing the sliding element toward the rear position;
a lever connected to the handle and operable to move the sliding element to the front position from the rear position; and
a linkage for connecting the lever to the sliding element so that the lever is operable to move the sliding element via the linkage, wherein the linkage comprises:
a first bar pivotally connected to the handle;
a second bar, a third bar, a fourth bar;
a first pin for connecting the first bar to the second bar;
a second pin for connecting the second bar to the third bar, and
a third pin for connecting the third bar to the fourth bar, wherein the first and third pins are in contact with and movable relative to the lever.

US Pat. No. 10,245,729

SENSORIZED COVERING FOR AN INDUSTRIAL DEVICE

Comau S.p.A., Grugliasco...

1. An automated device comprising:a movable structure;
an actuator for causing displacements of the movable structure;
a control system including a control unit and operable to control the actuator;
a sensorized covering for covering at least part of the movable structure,
wherein the sensorized covering comprises at least one of a contact sensor or a proximity sensor,
wherein the sensorized covering further comprises a plurality of covering modules mutually couplable in a separable way, each covering module of the plurality of covering modules including a respective load-bearing structure having a predefined shape to which at least one layer of elastically yielding material is connected,
wherein at least two of said plurality of covering modules each having connected thereto at least one of:
an electrical connector operable to electrically interconnect in a separable way the at least two covering modules to each other, or
a mechanical connector operable to mechanically interconnect in a separable way the at least two covering modules positioned adjacent to each other.

US Pat. No. 10,245,728

MONITORING SYSTEM

PMDTECHNOLOGIES AG, Sieg...

1. A monitoring system, comprising:at least one three-dimensional (3D) time-of-flight (TOF) camera configured to monitor a safety-critical area;
an evaluation unit configured to activate a safety function upon an entrance of at least one of an object and a person into the monitored area and to suppress the activation of the safety function where at least one clearance element is recognized as being present on the at least one of the object and the person, the at least one clearance element including a marking that is detectable by the at least one 3D TOF camera and identifies the at least one clearance element based on at least one of a specified optical property and a specified geometrical property of the marking.

US Pat. No. 10,245,724

SYSTEM, METHOD AND PRODUCT FOR UTILIZING PREDICTION MODELS OF AN ENVIRONMENT

SHMUEL UR INNOVATION LTD....

1. A method comprising:obtaining a first scene of an environment from one or more sensors, wherein the one or more sensors observe scenes of the environment;
predicting, using a model of the environment and based on the first scene of the environment, a predicted second scene of the environment;
obtaining an observed second scene from the one or more sensors, wherein the observed second scene occurs later in time than the first scene;
wherein prior to said obtaining the observed second scene, performing computations based on the predicted second scene;
comparing the predicted second scene with the observed second scene; and
performing an action, using the computations and based on differences determined in said comparing between the predicted second scene and the observed second scene, whereby utilizing the computations based on the predicted second scene to reduce response time of performing the action in response to the observed second scene.

US Pat. No. 10,245,719

TELESCOPING UTILITY LINE POLE

UTILITY SOLUTIONS, INC., ...

10. A telescoping utility line pole, comprising:(a) an outer pole section having an inner bore defined by an inner surface, the inner surface extending an entire overall length of the outer pole section, the outer pole section having:
(i) a plurality of spaced-apart raised sections extending radially inward away from the inner surface, the plurality of spaced-apart raised sections being disposed around a circumference of the inner surface at a distal end of the outer pole section to define spaces therebetween, wherein each of the spaces has an open first end and an open second end such that segments of the inner surface extend through the spaces, the plurality of spaced-apart raised sections extend between a first end located at the distal end of the outer pole section and a second end spaced away from the first end a distanced less than the overall length of the outer pole section;
(b) an inner pole section configured for mating engagement with the outer pole section and having a first outer diameter smaller than a first inner diameter defined by the inner bore and smaller than a second inner diameter defined by the raised sections to form the utility line pole, the inner pole section having a plurality of lugs positioned around a periphery of a distal end of the inner pole section, the plurality of lugs having a second outer diameter smaller than the first inner diameter and greater than the second inner diameter;
(c) wherein the spaces have a defined spacing equal to a defined spacing of the plurality of lugs such that when:
(i) the plurality of lugs and spaces are in a first position, the plurality of lugs align with the spaces and permit the inner pole section to slide axially into engagement with or slide axially out of engagement with the outer pole section; and
(ii) the plurality of lugs and spaces are in a second position, the plurality of lugs are misaligned with the spaces and the plurality of raised sections interfere with the plurality of lugs and block the inner pole section from sliding into and out of engagement with the outer pole section.

US Pat. No. 10,245,718

PROTECTION APPARATUS FOR A MACHINE TOOL, AT LEAST FOR PROTECTING A WORKPIECE SURFACE AGAINST OVERHEATING

Robert Bosch GmbH, Stutt...

1. A protection apparatus of a machine tool for protecting at least a workpiece surface against overheating, comprising:at least one sensor unit including at least one sensor element that detects at least one characteristic variable of a fluid flow provided for transporting material removed from a workpiece; and
at least one evaluation unit that enables identifying at least one temperature of a workpiece surface of the workpiece to be machined by the machine tool based at least in part upon the at least one characteristic variable detected via the at least one sensor unit,
wherein the at least one sensor unit further includes at least one further sensor element that detects at least one characteristic volumetric flow rate variable of the fluid flow.

US Pat. No. 10,245,706

TOOL FOR FINE MACHINING OF SURFACES

Kolthoff Gabrovo EOOD, G...

1. A tool for fine machining of surfaces, the tool comprising:a working medium carrier comprising a top face and a bottom face, wherein the bottom face is an attachment side;
a set of individual exchangeable strip-shaped lamella holders, each comprising one or more lamellas in individual or bundled arrangement, wherein the lamellas each are oriented away from the attachment side of the working medium carrier and form in a downward direction remote from the attachment side a common working plane;
wherein the lamella holders on a side facing the attachment side are provided with hooking elements and wherein the attachment side of the working medium carrier is provided with hooking receptacles that are complementary to the hooking elements;
wherein the hooking elements are configured to be directly inserted into the hooking receptacles in a direction perpendicular to a downward face of the attachment side;
wherein the hooking elements comprise first undercut faces and the hooking receptacles comprise second undercut faces complementary to the first undercut faces, wherein the lamella holders, after directly inserting the hooking elements into the hooking receptacles in the perpendicular direction, are moved parallel to the attachment side so that the first and second undercut faces engage each other and hook the hooking elements and the hooking receptacles relative to each other, wherein the lamella holders are locked at the working medium carrier solely by the hooking elements and the hooking receptacles.

US Pat. No. 10,245,702

CONTROL OF WET ABRASIVE BLASTERS

Graco Minnesota Inc., Mi...

1. An incoming water control for use in a wet abrasive blasting system that includes a blast pot pressure vessel for containing water and abrasive, a hose that connects an outlet of the blast pot pressure vessel to a mixing point at which water abrasive mixture is mixed with compressed air, and a blast nozzle from which an air water abrasive mixture is delivered, the water control comprising:an incoming water supply that delivers water with a pressure of between 1 psi and 200 psi through a water supply line;
a pressure reducing valve disposed on the water supply line and configured to regulate and maintain the pressure of water from the incoming water supply below 20 psi; and
a water pump connected to the water supply line and disposed downstream of the pressure reducing valve, wherein the water pump includes check valves that receive water having a water pressure of less than 20 psi from the pressure reducing valve and delivers water to the blast pot pressure vessel to pressurize the blast pot pressure vessel filled with water and abrasive.

US Pat. No. 10,245,686

CONDITIONING METHOD OF GAS TURBINE ENGINE COMPONENTS FOR AERODYNAMIC NOISE REDUCTION

EnvAerospace Inc., Bramp...

2. A conditioning method of gas turbine engine components for aerodynamic noise reduction being provided by ion conditioning in physical vapor deposition process, after two stage surface preparation including a traditional finishing process to smooth the surface until the surface roughness (Ra) reaches a maximum 250 nanometers and a washing process. The ion conditioning process comprises at least three of the following intermediate stages and performed not in the presented order:a glow discharge cleaning;
an arc discharge cleaning;
a direct smoothing;
a surface glancing; and
a surface relaxation;to reach a surface roughness (Ra) below 150 nanometers resulting in conditioned components.

US Pat. No. 10,245,678

MANAGEMENT METHOD OF POWDER SUPPLY HEAD, AND METHOD AND APPARATUS FOR FORMING EROSION SHIELD

MITSUBISHI HITACHI POPOWE...

1. A management method of a powder supply head which has a double tube in which an inner circumference side tube that sprays a cladding metal used for cladding by welding using a laser and an outer circumference side tube that is disposed at an outer circumference of the inner circumference side tube and sprays a shielding air overlap concentrically, and supplies the cladding metal to a cladding portion, the method comprising:a spraying process of spraying the cladding metal from the powder supply head to a test region under set conditions and forming a line segment by the cladding metal sprayed to the test region;
a width measurement process of measuring a width of the cladding metal sprayed onto the test region;
a determination process of, in a case where the measured width of the cladding metal is an allowance or smaller, determining that the powder supply head is usable, and in a case where the measured width of the cladding metal is greater than the allowance, determining that the powder supply head is unusable.

US Pat. No. 10,245,674

SYSTEMS AND METHODS FOR PLASMA GAS VENTING IN A PLASMA ARC TORCH

Hypertherm, Inc., Hanove...

1. A plasma cutting system comprising:a torch body having a proximal end and a distal end defining a longitudinal axis extending therethrough;
a torch tip having a proximal end and a distal end, the torch tip located at the distal end of the torch body and including a plasma plenum and a plasma arc exit orifice located at the distal end of the torch tip;
a lead connector disposed on the proximal end of the torch body and connectable to a torch lead at the proximal end of the torch body, the torch lead having a proximal end and a distal end;
an atmospheric vent port from the plasma plenum and disposed between the plasma arc exit orifice and the distal end of the torch lead, the atmospheric vent port having an outer opening exposed to atmosphere, the outer opening disposed upstream of the proximal end of the torch tip and downstream of the distal end of the torch lead; and
a conduit fluidly connecting the plasma plenum and the atmospheric vent port, the conduit comprising:
a first channel configured to direct a portion of ionized gas from the plasma plenum in a first direction axially away from the plasma arc exit orifice; and
a second channel, fluidly connected between the first channel and the atmospheric vent port, configured to direct the portion of ionized gas from the first channel to the atmospheric vent port.

US Pat. No. 10,245,669

DEVICE AND METHOD FOR AUTOGENOUS PROCESSES

Linde Aktiengesellschaft,...

1. An enveloping gas device for transporting at least one enveloping gas, wherein the enveloping gas device is allocated to a burner head or at least one nozzle of a device provided for working or processing at least one component or workpiece by autogenous processes selected from the group consisting of autogenous flame cutting, autogenous flame brazing, and autogenous flame gouging, characterized in that at least one burner flame issuing from the burner head or nozzle and directed towards the component or workpiece is completely enclosed by the enveloping gas which is not consumed by the at last one burner flame, and concentrating the flame on the at least one component or workpiece and the concentration of contaminants contained in the waste gas from the device is reduced by the enveloping gas, wherein an end area of the enveloping gas device facing the component or workpiece protrudes slightly beyond end area of the burner head or the nozzle that faces the component or workpiece.

US Pat. No. 10,245,663

AIRFLOW MANAGEMENT SYSTEM FOR A POWER TOOL

Robert Bosch Tool Corpora...

1. A table saw comprising:a lower guard assembly including a dust exhaust chute, the lower guard assembly being configured to at least partially enclose a lower portion of a saw blade;
a first airflow fan positioned in the lower guard assembly and configured and arranged to produce a first airflow directed through the lower guard assembly toward the dust exhaust chute;
a second airflow fan positioned in the lower guard assembly and configured to produce a second airflow directed through the lower guard assembly toward the dust exhaust chute, the first and second airflows forming a combined airflow directed toward the dust exhaust chute;
a motor configured to rotationally drive an output shaft; and
a drivetrain system connecting the output shaft to the first airflow fan and the saw blade to enable the motor to rotationally drive the first airflow fan, the second airflow fan, and the saw blade simultaneously.

US Pat. No. 10,245,650

CHUCKING DEVICE

Haimer GmbH, Igenhausen ...

1. A chucking device for a tool, said chucking device comprising:a tool receiving element;
a collet for clamping the tool, said collet being inserted into an opening in the tool receiving element;
a clamping nut for axially displacing the collet in relation to the tool receiving element; and
a pressure piece which is disposed between the clamping nut and the collet and is rotatably mounted in relation to the clamping nut, such that the pressure piece allows the collet to be axially displaced in relation to the tool receiving element by the clamping nut,
wherein the pressure piece comprises coupling elements for a torsion-proof connection to corresponding mating elements of the tool receiving element,
the pressure piece and the collet are connected by a coupling so as to be torsion-proof and detachable in such a manner that the pressure piece and the collet assume a predefined angular position in relation to each other when connected by the coupling,
one of the collet and the tool receiving element includes detent lugs for torsion-proof engagement in corresponding detent grooves of the other of the collet and the tool receiving element, the detent lugs engaging in the detent grooves by a rotational movement relative to each other, and
the detent grooves or detent lugs of the tool receiving element are positioned at the same angle relative to the mating elements of the tool receiving element as the detent lugs or detent grooves of the collet are positioned relative to the coupling elements of the pressure piece.

US Pat. No. 10,245,640

DEVICE AND A METHOD FOR CONSOLIDATION OF POWDER MATERIALS

GENICORE SPOLKA Z OGRANIC...

1. A method of powder materials consolidation, comprising locating a sintered powder in a die between two electrodes connected to press exerting pressure thereon, applying voltage to the electrodes through a capacitive circuit with a power supply unit closed by a high-current switch, subjecting the sintered powder to simultaneous operation of pressure in the range of 1-200 MPa and consolidation by pulses of electric current with an intensity of 1-80 kA, repeated with frequency of 0.1 Hz to 100 Hz, generated by opening and closing a high-current transistor switch connected in series to the sintered powder and discharging a battery of capacitors in a capacitive circuit charged to the voltage of 0.5-15 kV with rectangular pulses of electric current.

US Pat. No. 10,245,631

ROLLER SET AND PIPE ELEMENTS

Victaulic Company, Easto...

1. A roller set for forming regions of a pipe element having an inner and an outer surface, said roller set comprising:an inner roller engageable with said inner surface, said inner roller comprising an inner roller body, a flange extending circumferentially around said inner roller body;
an outer roller engageable with said outer surface, said outer roller comprising:
an outer roller body rotatable about a first axis, said inner roller body being rotatable about a second axis, said flange projecting transversely to said second axis and being engageable with an end of said pipe element;
a first raised feature comprising a first summit, engageable with said pipe element and extending circumferentially about said outer roller body and projecting radially from said first axis;
a second raised feature comprising a second summit, engageable with said pipe element and extending circumferentially about said outer roller body and projecting radially from said first axis, said second raised feature being positioned adjacent to said first raised feature;
a third raised feature comprising a third summit, engageable with said pipe element and extending circumferentially about said outer roller body and projecting radially from said first axis, said second raised feature being positioned between said first and third raised features; wherein
said first and third summits are arranged in spaced relation away from said second summit.

US Pat. No. 10,245,627

WIDTH AND SPEED CONTROL FOR SHEET METAL DESCALER AND METHODS OF USING SAME

THE MATERIAL WORKS, LTD.,...

1. An apparatus that removes scale from sheet metal, the apparatus comprising:a descaler that receives lengths of sheet metal and removes scale from at least one surface of the length of sheet metal as the length of sheet metal is moved in a first direction through the descaler;
a supply of a scale removing medium communicating with the descaler and supplying the scale removing medium to the descaler via first and second nozzles, the first and second nozzles each having an actuator configured to rotate the respective nozzle;
first and second wheels on the descaler positioned adjacent the at least one surface of the length of sheet metal passed through the descaler, each of the first and second wheels being configured to receive the scale removing medium from the supply of scale removing medium via the rotatable nozzles, the first wheel having an axis of rotation different from the second wheel, rotation of the first wheel causing the scale removing medium received by the first wheel via the first nozzle to be propelled from the first wheel against the at least one surface across substantially an entire width of the sheet metal and rotation of the second wheel causing the scale removing medium received by the second wheel via the second nozzle to be propelled from the second wheel against the at least one surface across substantially an entire width of the sheet metal, the second wheel being spaced from the first wheel along the first direction a distance sufficient such that the scale removing medium propelled from the second wheel does not substantially interfere with the scale removing medium propelled from the first wheel, the first wheel and the second wheel being positioned adjacent opposite side edges defining the width of the sheet metal with the sheet metal centered between the first wheel and the second wheel; and
a control system in communication with the actuators of the first and second nozzles, and in communication with at least three sensors configured to detect a surface condition of the at least one surface of the sheet metal after the scale removing medium has been propelled against the at least one surface of the sheet metal by the first and second wheels, one of the at least three sensors comprising a center sensor configured to detect the surface condition of the at least one surface of the sheet metal in a center of the width of the sheet, two of the at least three sensors comprising edge sensors, one of the edge sensors being configured to detect the surface condition of the at least one surface of the sheet metal adjacent to one side edge defining the width of the sheet metal, the other of the edge sensors being configured to detect the surface condition of the at least one surface of the sheet metal adjacent to the opposite side edge defining the width of the sheet metal, the control being configured to: (a) receive signals indicative of a surface condition of the at least one surface of the sheet metal as detected by the respective sensor, (b) compare the signals received from the center sensor with each of the signals received from the edge sensors, and (c) transmit positional control signals to each of the nozzle actuators to rotate the respective nozzle relative to the wheel based upon the comparison of the signal of center signal with the signal of at least one of the edge sensors; and
wherein the control is further configured such that when the comparison of the edge sensor signal to the center sensor signal is indicative that a surface condition of the respective edge of the at least one surface of the sheet metal is more favorable than a surface condition of the center of the at least one surface of the sheet metal, the control is configured to transmit the positional control signal to the nozzle actuator to rotate the nozzle relative to the respective wheel in a manner such that a concentration of the scale removing medium propelled by the respective wheel against the at least one surface across substantially an entire width of the sheet metal moves toward the center of the sheet metal; and
wherein the control is further configured such that hen the comparison of the edge sensor signal to the center sensor signal is indicative that a surface condition of the center of the at least one surface of the sheet metal is more favorable than a surface condition of the respective edge of the at least one surface of the sheet metal, the control is configured to transmit the positional control signal to the nozzle actuator to rotate the nozzle relative to the respective wheel in a manner such that a concentration of the scale removing medium propelled by the respective wheel against the at least one surface across substantially an entire width of the sheet metal moves away from the center of the sheet metal.

US Pat. No. 10,245,626

MINE DRAINAGE REMEDIATION USING BARIUM CARBONATE DISPERSED ALKALINE SUBSTRATE

UNIVERSITY OF THE FREE ST...

1. A fixed-film bioreactor for bio-remediation, or at least partial bio-remediation, of environmental media contaminated with a source of mine drainage (MD), and wherein the bioreactor is a down-flow reactor with a supernatant open to the atmosphere in order to maximize iron oxidation and to minimize iron (II) mobility in the bioreactor, said fixed-film bioreactor including:(i) a support matrix;
(ii) a barium carbonate BaCO3 alkaline substrate for removing sulphate, cation, electrical conductivity (EC) and total dissolved solids (TDS) by precipitation; and
(iii) a microbial consortium for removing nitrates and cyanide.

US Pat. No. 10,245,623

CONTAMINATION REMOVAL APPARATUS AND METHOD

RAVE N.P., INC., Delray ...

1. A substrate dry cleaning apparatus, comprising:a first conduit defining a first flow channel therein, the first conduit further defining a first exit aperture in fluid communication with the first flow channel;
a first electrode disposed in a vessel;
a second electrode facing the first electrode, the first flow channel disposed between the first electrode and the second electrode; and
a metal including indium, lead, bismuth, or combination thereof filling all of a gap between the first electrode and the vessel.

US Pat. No. 10,245,621

SORTING INSTALLATION AND METHOD FOR SEPARATING MATERIAL FRACTIONS

Unisensor Sensorsysteme G...

1. A device for separating one or a plurality of material fractions from at least one material stream of free-flowing bulk material, the device comprising:a directing apparatus (12) by way of which the material stream is guided under the influence of gravity;
an optical scanning apparatus (16) for spectroscopic identification of at least one of composition-dependent or consistency-dependent properties of individual fragments (13) that are contained in the material stream; and
a separation apparatus (14) for mechanically separating the individual fragments that are contained in the material stream, depending on identification results of the optical scanning apparatus (16);
the directing apparatus (12) is configured as a shell surface of a downwardly widening rotational solid or truncated pyramid; and
the optical scanning apparatus (16) has
a light source (17), disposed within a base area of an axial projection of the rotational solid or truncated pyramid, that generates a light beam, and
a rotating optical deflection element (19) which is disposed so as to deflect the light beam in such a manner that the light beam intersects the material stream that is distributed across the shell surface of the directing apparatus (12) in a scanning plane below the rotational solid or truncated pyramid;
wherein a plurality of the silos which are sector-shaped silos (11a-11h) from which a plurality of material streams are routed by way of the directing apparatus (12) are disposed above the directing apparatus (12), and two or more respective selection channels (15a, 15b) that are disposed on different radii from the axis of the rotational solid or truncated pyramid are provided for each of the silos (11a-11h) below the directing apparatus (12), and
the directing apparatus has substantially vertically running separation webs for separating dissimilar material streams en route along the directing apparatus (12).

US Pat. No. 10,245,619

FOODSTUFF SIEVE STATION

Electrolux Professional S...

1. A foodstuff sieve station comprising a sifting assembly which is structured to receive a floury foodstuff preparation to be sifted, and to sift said floury foodstuff preparation for separating the dough balls and/or other impurities from the still-usable floury foodstuff preparation;wherein the sifting assembly comprises:
a substantially hopper-shaped, outer casing which is arranged with the upper inlet mouth of the casing faced upwards to receive the floury foodstuff preparation to be sifted;
a substantially bell-shaped, rotatable sieve member which is housed/recessed inside said substantially hopper-shaped, outer casing substantially coaxial to a given reference axis tilted to the vertical by an angle greater that 0° and lower that 90°; with the mouth of the bell-shaped sieve member faced upwards, so as to receive the floury foodstuff preparation to be sifted; and
a motor assembly which is capable of driving into rotation the bell-shaped sieve member about said reference axis;
the bell-shaped sieve member being structured/designed to prevent the dough balls and/or other impurities to freely flow through the body of the same sieve member, and being moreover internally provided with at least one inwardly protruding, substantially helical-shaped assembly that projects from the inner surface of the bell-shaped sieve member and extends along the same inner surface of the bell-shaped sieve member according to a substantially helical-shaped path substantially from the bottom of the sieve member up to the mouth of the same sieve member.

US Pat. No. 10,245,615

SURFACE TREATMENT

COMMONWEALTH SCIENTIFIC A...

16. A polymer composite having a functionalized surface property, the polymer composite comprising:a substrate having at least a top surface layer formed of a polymeric material having an elastic modulus of no more than 1500 MPa, the polymeric material defining a top surface plane of the polymer composite, and
particles having a functional property embedded in the top surface layer of the polymeric material by a spray mechanism in which the particles are accelerated and sprayed onto the top surface layer with a suitable velocity such that at least some of the particles are embedded completely below the top surface plane of the polymer composite, wherein
the embedded particles are present as separate entities and do not form a continuous layer on the top surface layer of the substrate, and wherein
any individual entity of the particles embedded completely below the top surface plane of the polymer composite is in a respective pocket in the polymeric material, the respective pocket formed by impact of the particle on the top surface layer of polymeric material, wherein the respective pocket is a crater or a cavity, and wherein
the respective pocket includes an open-ended channel providing direct open fluid communication between a particle embedded in the respective pocket and the top surface plane of the polymeric material, wherein the open-ended channel has a first cross-section width less than that of a diameter of a particle located within the respective pocket, the first cross-section width measured in a direction parallel to the top surface plane of the polymer composite, and wherein
any of the particles embedded completely below the top surface plane of the polymer composite in one of the respective pockets is unconnected directly through the polymeric material forming the top surface layer of the polymer composite by the open-ended channels to adjacent particles embedded completely below the top surface plane of the polymer composite in other respective pockets to thereby not be in fluid communication with the adjacent particles directly through the polymeric material.

US Pat. No. 10,245,609

FITMENT AND FITMENT ADAPTER FOR DISPENSING SYSTEMS AND METHODS FOR MANUFACTURING SAME

Entegris, Inc., Billeric...

1. A fitment assembly, comprising:a fitment for defining a rigid fluid pathway between an interior and an exterior of a container, the fitment including:
a tubular body having an upper neck portion and a lower neck portion, said lower neck portion depending from said upper neck portion, said upper neck portion including a proximal end defining a proximal opening, said lower neck portion including a distal end defining a distal opening, said tubular body defining a central bore that passes therethrough, said central bore being concentric about a central axis and passing through said proximal opening and said distal opening; and
a flange for coupling with a container, said flange extending radially outward at a junction with said upper neck portion and said lower neck portion,
wherein the lower neck portion is configured to extend into the interior of the container and wherein said lower neck portion includes a plurality of vent openings spaced apart from one another about a circumference of the lower neck portion, the vent openings passing through a thickness of the lower neck portion in a generally radial direction from an outside surface of the lower neck portion to an inner surface of the lower neck portion for permitting fluid flow therethrough.

US Pat. No. 10,245,607

METHOD AND APPARATUS FOR DISPENSING FLUID

Graco Minnesota Inc., Mi...

1. A method of dispensing a fluid, the method comprising:charging a fluid to a pressure with a prime mover having a motor and a pump, wherein a controller directs the prime mover to charge the fluid to the pressure;
cycling a downstream valve open and closed at a fixed frequency, wherein the valve is configured to cycle between fully opened and fully closed according to a variable duty-cycle;
sensing a valve-open time;
varying the valve-open time, by a controller, to maintain a desired flow rate at a downstream dispenser; and
altering the pressure generated by the prime mover, by the controller, based on the sensed valve-open time, such that the pressure is increased as the valve-open time approaches 100 percent of the frequency, and the pressure is decreased as the valve-open time approaches zero percent of the frequency.

US Pat. No. 10,245,603

VOLATILIZATION DEVICE CAPABLE OF AUTOMATIC QUANTITATIVE SUPPLEMENT OF LIQUID

GUANGZHOU FANER AROMA PRO...

1. A volatilization device capable of automatic quantitative supplement of liquid, comprising:a vaporizer, defining an accommodation space and having an opening, an air inlet and a liquid inlet, said accommodation space being in communication with said opening, said air inlet and said liquid inlet;
a gas supply, in corresponding connection with said gas inlet, allowing said gas supply to input gas to said vaporizer so as to generate a gas flow in the accommodation space of said vaporizer; and
a liquid supply, provided with a liquid container, a controller and a press piece, said liquid container being in connection with said controller and said press piece, said controller being in corresponding connection with said liquid inlet, allowing said liquid supply to input liquid to the accommodation space of said vaporizer,
wherein said controller is operable to control the press piece to withdraw said liquid from said liquid container to the accommodation space of said liquid inlet, wherein the liquid is converted into aerosol with the gas flow generated in the accommodation space and the aerosol is ejected outward from said opening of said vaporizer; and
wherein said vaporizer comprises a reflux tube, which has an end in connection with the accommodation space of said vaporizer and an opposite end connected to said liquid container, such that an excessive amount of said liquid accumulated in the accommodation space of said vaporizer is conducted from said vaporizer back to said liquid container through said reflux tube.

US Pat. No. 10,245,599

SPRAY NOZZLE

GEBERIT INTERNATIONAL AG,...

1. A spray nozzle for a sanitary article, in particular for a urinal, said spray nozzle comprising:a nozzle head which comprises a nozzle channel which extends along a center axis and has a nozzle inlet and a nozzle outlet,
a pipe section which comprises an interior with an inlet, to which a water pipe is connectable, and an outlet, and
a cover which covers the nozzle head at its front side and which is in connection with the pipe section, wherein, in the connected state, in the region of the nozzle outlet, the cover maintains an interspace through which the water is suppliable from the nozzle outlet to the sanitary article,
wherein the nozzle head is mounted in the interior,
wherein the nozzle inlet is accessible from the interior such that flushing water is able to enter into the nozzle channel from the interior and the nozzle outlet projects out of the interior,
wherein the nozzle head is secured with reference to the interior of the pipe section by means of a securing element,
wherein the securing element is a groove and tongue connection between the nozzle head and the interior;
wherein said groove and tongue connection comprises at least one part portion which, with reference to the center axis, is formed at least in part circumferential and extending along the center axis in such a manner that a rotation of the nozzle head in the fixed interior results in an axial displacement along the center axis;
wherein the nozzle head and the pipe section include alignment elements such that, in its installation position, the nozzle head is mounted in the interior so as to be non-rotatable with reference to a movement about the center axis; and
wherein said groove and tongue connection provides the alignment element.

US Pat. No. 10,245,598

LABORATORY CENTRIFUGE AND METHOD FOR OPERATING THE SAME WITH A REVERSED DRIVING MOTION OF THE ROTOR DURING ACCELERATION AND DECELERATION

SIGMA LABORZENTRIFUGEN GM...

2. A method for operating a laboratory centrifuge for centrifuging a product, the laboratory centrifuge comprising a rotor which rotates around a horizontal rotational axis, the product being held at the rotor at a distance of the rotational axis, whereina) the rotor is decelerated from a reversing angular position, wherein the product is located in a twelve o'clock position and comprises an angular velocity such that a centrifugal acceleration acting upon the product is larger than a gravitational acceleration, to an angular velocity of zero for a first arrival in a resting angular position, wherein the product is located between a six o'clock position and a nine o'clock position,
b) during the deceleration the product passes a six o'clock position and the deceleration from the reversing angular position to the first arrival in the resting angular position is provided over an angle of between 180° to 270° and
c) when moving towards the resting angular position during the deceleration the rotor is rotated with a first sense of rotation and there is a subsequent reversing rotation with an opposite sense of rotation from the resting angular position into an unloading position.

US Pat. No. 10,245,596

ELECTROSTATIC MODIFICATION REAGENT AND PROCESS FOR ENHANCING ELECTROSTATIC SEPARATION IN THE BENEFICIATION OF ORES

Cytec Technology Corp., ...

1. An electrostatic modification reagent for beneficiating a mineral substrate by electrostatic separation, wherein the mineral substrate includes a conducting mineral component and/or a non-conducting mineral component, said reagent comprising:at least one electrostatic modifier comprising an organic compound selected from the group consisting of
quaternary amines; imidazoline compounds; dithiocarbamate compounds; pyridine compounds; pyrrolidine compounds; conducting polymers; polyethyleneimines; compounds of formula (IV):
R—(CONH—O—X)n  (IV)
wherein n of formula (IV) is 1 to 3; wherein R of formula (IV) comprises from 1 to 50 carbons; and wherein each X of formula (IV) is individually selected from the group consisting of H, M, and NR?4, where M is a metal ion and each R? is individually selected from the group consisting of H, C1-C10 alkyl, C6-C10 aryl, C7-C10 aralkyl, and C10-C18 naphthylalkyl;
compounds of formula (VI):

wherein R8 of formula (VI) is selected from the group consisting of H, C1-C22 alkyl, C6-C22 aryl, C7-C10 aralkyl, and C10-C18 naphthylalkyl; and X of formula (VI) is selected from the group consisting of H, M, and NR?4, where M is a metal ion and each R? is individually selected from the group consisting of H, C1-C10 alkyl, C6-C10 aryl, C7-C10 aralkyl and C10-C18 naphthylalkyl;
and mixtures thereof;
a plurality of particles having an average specific resistivity that is greater than or equal to the specific resistivity of the non-conducting mineral component of the mineral substrate when the non-conducting mineral component is electrostatically modified; and/or
a plurality of particles having an average specific resistivity that is less than or equal to the specific resistivity of the conducting mineral component of the mineral substrate when the conducting mineral component is electrostatically modified,
wherein the electrostatic modifier and plurality of particles are present in a weight ratio of electrostatic modifier to particles of from 100:1 to 1:100.

US Pat. No. 10,245,591

BEARING ELEMENT SUITABLE FOR SUPPORTING A GRINDING TABLE IN A ROLLER MILL

GEBR. PFEIFFER SE, Kaise...

1. A bearing element suitable for supporting a grinding table in a roller mill, comprisinga plate or disk-shaped base element,
an annular disk,
a spacer element and axial bearing segments, wherein the annular disk is disposed substantially parallel to the base element and spaced apart from the base element, and is connected at its bottom by means of an annular spacer element with the base element,
characterized in that the annular disk has means on its upper side for receiving the axial bearing segments and that the spacer element is designed as an annular strip extending in the axial direction and has a plurality of spaced-apart arches in the circumferential direction, the openings of which point towards the base element.

US Pat. No. 10,245,587

INSTRUMENT SYSTEMS FOR INTEGRATED SAMPLE PROCESSING

10X GENOMICS, INC., Plea...

1. A system for processing samples, comprising:a microfluidic device including a plurality of channel networks configured to partition said samples into partitioned samples, wherein a channel network of said plurality of channel networks is connected to an inlet reservoir and an outlet reservoir;
an instrument configured to interface with said microfluidic device and apply a pressure differential between said inlet reservoir and said outlet reservoir to subject fluid within said channel network to movement; and
a holder configured to receive said microfluidic device; and
a rotatable body coupled to said holder, wherein said rotatable body is configured to rotate from a closed configuration to an open configuration, or vice versa,
wherein said holder is configured to (i) secure said microfluidic device and permit said instrument to interface with said microfluidic device to apply said pressure differential when said rotatable body is in said closed configuration, and (ii) permit said microfluidic device to be inserted into or removed from said holder when said rotatable body is in said open configuration.

US Pat. No. 10,245,585

SPECIMEN DELIVERY APPARATUS

PARATUS DIAGNOSTICS, LLC,...

1. A specimen processing apparatus comprising:a housing having a fluid supply reservoir, a specimen receiving chamber, a specimen collection reservoir, and an actuator coupled to the fluid supply reservoir; and
a liquid flow path extending from the fluid supply reservoir to the specimen receiving chamber, and to the specimen collection reservoir,
wherein the actuator is operable to propel a liquid from the fluid supply reservoir to the specimen receiving chamber,
wherein the specimen receiving chamber comprises an inlet port, an outlet port, and a fluid flow guide disposed between the inlet port and the outlet port,
wherein the fluid supply reservoir is fluidly coupled to the inlet port and the outlet port is fluidly coupled to the specimen collection reservoir,
wherein the inlet port is aligned with a circumferential surface of the specimen receiving chamber, and
wherein the specimen receiving chamber comprises a swab shaft seal comprising one or more circular seals operable to engage and form a fluid seal against a shaft of a sample collection device.

US Pat. No. 10,245,577

REMOVAL OF OZONE FROM ELECTROKINETIC DEVICES

Inspirotec, Inc., Lake B...

1. An electrokinetic air propulsion device, comprising:a housing having an inlet and an outlet;
a high voltage electrode and a propulsion electrode in said housing, wherein the high voltage electrode and the propulsion electrode are positioned between the inlet and the outlet and
wherein the high voltage electrode and the propulsion electrode are configured to be at different potentials to generate air flow in the housing from the inlet to the outlet; and
a shell secured to the housing and overlaying the outlet, wherein a porous support medium coated with ozone-destroying catalyst is disposed in the shell, the porous support medium having a cell density in the range 10 to 1000 cells/inch and having a size at least as large as size of the housing outlet such that the air flow from the outlet is forced through said porous support medium.

US Pat. No. 10,245,572

FLUID MIXING SYSTEM

Potable Water Solutions, ...

1. A fluid mixing system, comprising:a. an upper portion, comprising an upper piping assembly and a submersible pump housed within the upper piping assembly;
b. a base portion connected to the upper portion, the base portion comprising a bottom piping assembly and one or more diffusers connected to opposing horizontal extending end portions of the bottom piping assembly, wherein the upper portion and the base portion form an inverted T configuration the upper portion being substantially vertical and the base portion being substantially horizontal; and wherein the upper portion and the base portion are configured for being installed within a fluid reservoir; and
c. a fluid path fluidly connecting the upper piping assembly and bottom piping assembly, wherein the fluid path extends from an outlet of the submersible pump to the one or more diffusers, and wherein the one or more diffusers are configured to provide a fluid outlet from the fluid path to create movement of fluid within a fluid reservoir, and wherein the one or more diffusers are positioned at a certain fixed angle relative to the bottom piping assembly and/or a horizontal surface of a bottom of the fluid reservoir which the fluid mixing system is installed wherein each of the opposing end portions of the bottom piping assembly each comprises a T pipe assembly.

US Pat. No. 10,245,567

MIXING AND DELIVERY METHOD ARRANGEMENT AND PUMP FOR SUPPLYING SMALL PARTICLES SUSPENDED IN A LIQUID TO FORM SLURRY FOR DELIVERY

OUTOTEC (FINLAND) OY, Es...

1. A mixing and delivery arrangement for supplying small particles suspended in a liquid to form a slurry for delivery, the mixing and delivery arrangement comprising:a container having an open top, an inner bottom and an inner wall limiting an inner space;
a mixing and delivery pump having:
a first shaft having a first distal end and a first proximal end;
a rotor connected to the first distal end of the first shaft and arranged at the inner bottom of the inner space of the container;
a first power device connected to the first proximal end of the first shaft so that the rotor is rotatable about a first rotation axis by means of the first power device, wherein the first power device is located outside the inner space of the container;
a stator having stator blades, wherein the stator coaxially surrounding the first shaft and wherein the stator being arranged at least partly between the first distal end of the first shaft and the proximal end of the first shaft;
a pump having at least one inlet, which is located in a stator space between two stator blades of the stator, and an outlet; and
an outlet pipe having a second inlet opening connected to the outlet of the pump and a second outlet opening located outside the inner space of the container;
wherein the rotor comprises a rim member that is coaxial with the first shaft and a plurality of rotor blades extending between the first shaft and the rim member, each rotor blade being in the form of a flat elongated plate member that is tilted and/or twisted with respect to a first reference plane perpendicular to the first rotation axis of the first shaft, each rotor blade extending perpendicularly with respect to the first rotation axis of the first shaft between the first shaft and the rim member, wherein the distance between a leading edge of each rotor blade and the inner bottom of the container being smaller than the distance between a trailing edge of each rotor blade and the inner bottom of the container,
wherein the container comprises an inner space, which has the form of a cylinder or a truncated cone, wherein the inner space is axially limited at one end by the inner bottom, which is circular, and radially limited by the inner wall, and the rotor has a diameter that is between about 85% and about 95% of the diameter of the inner bottom of the container,
wherein the pump of the mixing and delivery pump is located in the stator space between two stator blades of the stator, the pump having an impeller connected to a second distal end of a second shaft having a second proximal end connected to a second power device for rotating the impeller about a second rotation axis, and wherein the pump has a pump housing for housing the impeller, wherein the inlet, which is located in a stator space between two stator blades of the stator, is provided in the pump housing in the form of an axial inlet, and wherein the outlet of the pump is provided in the pump housing in the form of a tangential outlet,
wherein the second power device is located outside the inner space of the container.

US Pat. No. 10,245,562

PERVAPORATION MEMBRANES DERIVED FROM POLYCYCLO-OLEFINIC BLOCK COPOLYMERS

PROMERUS, LLC, Brecksvil...

1. A pervaporation membrane comprising a block copolymer of the formula (VI):(A)m-b-(B)n  (VI);
where each of m and n is an integer of at least 15;
b denotes a bond;
A and B are different from each other and independently selected from a repeat unit represented by formula (IVA), said repeat unit is derived from a monomer of formula (IV):

wherein:
denotes a place of bonding with another repeat unit;
p is an integer 0, 1 or 2;
R3, R4, R5 and R6 are the same or different and each independently of one another is selected from hydrogen, linear or branched (C1-C16)alkyl, hydroxy(C1-C16)alkyl, perfluoro(C1-C12)alkyl, (C3-C12)cycloalkyl, (C6-C12)bicycloalkyl, (C7-C14)tricycloalkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C3)alkyl, perfluoro(C6-C10)aryl, perfluoro(C6-C10)aryl(C1-C3)alkyl, di(C1-C2)alkylmaleimide(C3-C6)alkyl, di(C1-C2)alkylmaleimide(C2-C6)alkoxy(C1-C2)alkyl, hydroxy, (C1-C12)alkoxy, (C3-C12)cycloalkoxy, (C6-C12)bicycloalkoxy, (C7-C14)tricycloalkoxy, (C6-C10)aryloxy(C1-C3)alkyl, (C5-C10)heteroaryloxy(C1-C3)alkyl, (C6-C10)aryloxy, (C5-C10)heteroaryloxy or (C1-C6)acyloxy, where each of the aforementioned substituents are optionally substituted with halogen or hydroxy.

US Pat. No. 10,245,556

METHOD AND APPARATUS FOR EFFECTING HIGH RECOVERY DESALINATION WITH PRESSURE DRIVEN MEMBRANES

BEN GURION UNIVERSITY OF ...

1. A tapered flow desalination system comprising:a system inlet feed line coupled to a first high pressure booster pump configured to provide a high pressure feed stream to the system, wherein said first high pressure booster pump comprises an inlet and an outlet;
blocks of membrane pressure vessels arrayed in parallel, wherein the outlet of said first high pressure booster pump is coupled by means of flow lines to said blocks at first opening sides of said blocks;
a second high pressure booster pump, comprising an inlet and an outlet, coupled at said second high pressure booster pump inlet by a first bypass line parallel to said blocks, to said first high pressure booster pump outlet, wherein said second high pressure booster pump outlet and inlet are also coupled by means of flow lines to said blocks at second opening sides of said blocks and wherein said first bypass line is also coupled by means of flow lines to said blocks at said second opening sides of said blocks;
a system outlet flow line coupled to said first opening sides of said blocks by means of flow lines and coupled to said second opening sides of said blocks and to the second high pressure booster pump outlet, wherein said system outlet flow line is coupled to said second opening sides of said blocks and to said second high pressure booster pump outlet by means of a second bypass line;
wherein the first bypass line comprises a valve and wherein the second bypass line comprises a valve;
wherein at least two of the flow lines coupling between said first high pressure booster pump outlet and said first opening sides of said blocks each comprise a valve;
wherein at least two of the flow lines coupling between said second high pressure booster pump outlet and said second opening sides of said blocks each comprise a valve;
wherein at least two of the flow lines coupling between said second opening sides of said blocks and said second high pressure booster pump inlet each comprise a valve;
wherein at least two of the flow lines coupling between said first opening sides of said blocks and said system outlet flow line each comprise a valve; and
wherein said first bypass line is configured to bypass excess flow from said first high pressure booster pump outlet to the second high pressure booster pump inlet without changing said excess flow composition within said first bypass line.

US Pat. No. 10,245,554

GAS PURIFIER

Entegris, Inc., Billeric...

1. A gas purifier, comprising:a housing having a fluid inlet and a fluid outlet, the inlet and outlet fluidly connected through a purifier bed contained in the housing, the purifier bed comprising:
a first bed of purification media;
a second bed of purification media downstream of the first bed of purification media; and
a media-retaining, porous, gas-permeable membrane separating the first bed of purification media and the second bed of purification media, wherein the media-retaining, porous, gas-permeable membrane has a pore size to prevent particles of purification media from passing therethrough, the media-retaining, porous, gas-permeable membrane being secured at its edges to an inner surface of the housing; and
an expandable ring comprising an inner circumference, an outer circumference and a locking mechanism for expanding and retaining the ring by radial force against an inner wall of the housing when the locking mechanism is engaged,
wherein the first bed of purification media and the second bed of purification media are compositionally different and wherein the media-retaining, porous, gas-permeable membrane is secured to the inner surface of the housing at its edges by the expandable ring.

US Pat. No. 10,245,549

METHOD AND DEVICE FOR SEPARATING OFF ELECTROLYTES FROM SYNTHESIS GASES

LINDE AKTIENGESELLSCHAFT,...

1. A method for separating off an electrolyte from a first synthesis gas and a second synthesis gas, each containing an electrolyte, said method comprising:subjecting each of the two synthesis gases to a water scrubbing in a first water scrubber column and a second water scrubber column, respectively, wherein a substantially electrolyte-free synthesis gas and a scrubbing water loaded with electrolyte are separated and obtained,
wherein at least a part of the scrubbing water that is loaded with an electrolyte separated off in the scrubbing of the first synthesis gas is used as scrubbing medium for the scrubbing of the second synthesis gas, and
wherein said electrolyte in said first and second synthesis gases is ammonia and/or hydrogen chloride.

US Pat. No. 10,245,534

FILTER INLINE HEATER

Shaw Development, LLC, B...

1. A filter assembly for filtering aqueous urea solution comprising a housing defining an interior region and exterior region, the interior region and the exterior region being in fluid communication through a first aperture and a second aperture;a fluid filter within the housing, the filter separating the housing into
an upstream region upstream of the filter, the upstream region in fluid communication with the second aperture, and
a downstream region downstream of the filter, the downstream region in fluid communication with the first aperture;
a heater extending into the interior region of the housing;
a first hose fitting in fluid communicating with the first aperture, the first hose fitting formed of a material having a thermal conductivity of at least 16 W/(m*K);
a second hose fitting in fluid communicating with the second aperture, the second hose fitting formed of material having a thermal conductivity of at least 16 W/(m*K);
a heat bridge
formed of a conductive material having a thermal conductivity of at least 16 W/(m*K),
thermally connecting the heater to the first hose fitting, and
thermally connecting the heater to the second hose fitting; and
a first insulator
formed of a material having a thermal conductivity of at most 0.25 W/(m*K),
the first insulator at least partially covering the first hose fitting; and
a second insulator
formed of a material having a thermal conductivity of at most 0.25 W/(m*K),
the second insulator at least partially covering the second hose fitting.

US Pat. No. 10,245,531

HIGH-EFFICIENCY AUTOMATIC SELF-CLEANING STRAINER

TM Industrial Supply, Inc...

12. A method of reducing an amount of fluid used during a cleaning cycle of fluid strainer assembly, said method including:providing a body defining a chamber, the body including an inlet and outlet;
positioning a cylindrical screen within the chamber, said screen being supported by the body through which a fluid being filtered must pass, said cylindrical screen defining an internal portion;
positioning a backwash port within the internal portion of the screen, said backwash port being in fluid communication with a backwash pipe for directing fluid out of the fluid strainer assembly during a cleaning cycle, said backwash port comprising a rectangular member having an axially extending port defined by a top wall, a bottom wall, and a pair of parallel sidewall members, said top wall, bottom wall, and pair of sidewall members having end portions;
supplying the fluid to be filtered into the chamber;
rotating said backwash port about a central axis such that said end portions are in a close spaced proximity relationship with respect to an inner surface of said screen defining a space for the fluid being filtered to flow between said end portions and said inner surface of said screen causing a tangential flow and backflow of the fluid in order to dislodge and remove foreign material collected on the inner surface of the screen to flow into the backwash port and exit out a discharge outlet and backwash pipe; and
dimensioning the backwash port such that an area of draw is determined by equations: i) CS×1.875×1.5?A; and ii) A?CS of backwash pipe, where CS represents an internal transverse area of the backwash pipe and A represents the area of draw of the backwash port.

US Pat. No. 10,245,525

CLOSED-LOOP MULTI-STAGE CHILLED FILTER SYSTEM

Nextleaf Solutions Ltd., ...

1. A filtration system comprising a solvent vessel, a plurality of filter stages and the same plurality of transfer tubes wherein:each filter stage has:
a thermally insulated cylindrical side wall;
a lid that is removable from said wall;
a replaceable, elongated filter cartridge;
a support having a beveled edge that positions a base of said filter cartridge centrally in the filter stage;
an inlet port in the lid located to introduce liquid into the filter cartridge;
an inlet port located to introduce pressurized gas into the filter stage outside of the filter cartridge; and
a base with an outlet port that drains fluid from outside the filter cartridge;
the solvent vessel has:
a thermally insulated side wall;
an inlet port for introducing pressurized gas; and
an outlet tube having a first end located at a bottom region of the solvent vessel and a second end located outside the solvent vessel;
and the transfer tubes are each removably connected:
at an outlet end thereof to one of the inlet ports in one of the lids of the filter stages; and
at an inlet end thereof to either the second end of the outlet tube of the solvent vessel or the outlet port of another of said filter stages such that the solvent vessel and the filter stages are connected in series.

US Pat. No. 10,245,517

INTERACTIVE RIDE-ON TOY APPARATUS

Pacific Cycle, LLC, Madi...

1. An interactive ride-on toy apparatus comprising:a torso;
a plurality of legs secured to the torso;
a first drive motor assembly secured to a first of the plurality of legs and to a first drive wheel;
a second drive motor assembly secured to a second of the plurality of legs and to a second drive wheel;
a motorized neck assembly coupling a head to the torso, wherein the neck assembly provides a multi-directional rotational movement of the head relative to the torso;
a rechargeable battery;
a throttle switch to provide a throttle signal;
a controller including one or more processors and one or more memory devices; and
an electrical steering position sensor configured to translate a mechanical steering input via manual rotation of the head into an electronic steering position signal that is communicated to the controller, wherein the controller is configured to receive the throttle signal and the steering position signal, and selectively actuate at least one of the drive wheel motors based on the throttle signal and the steering position signal.

US Pat. No. 10,245,514

PLACEHOLDER ITEMS THAT CAN BE EXCHANGED FOR AN ITEM OF VALUE BASED ON USER PERFORMANCE

Kabam, Inc., San Francis...

1. A system for online gaming including virtual placeholder items in an online game, wherein users can exchange the virtual placeholder items for virtual items of value based on user achievements during gameplay in the online game, wherein the users are associated with client computing platforms, wherein the users include a first user associated with a first client computing platform and a second user associated with a second client computing platform, the system comprising:one or more physical processors configured by computer-readable instructions to:
execute an instance of the online game, and use the instance of the online game to facilitate interaction of the users with the online game through the client computing platforms that are associated with the users;
manage inventories associated with the users in the online game, wherein the inventories include an inventory available to the second user, wherein the inventory includes a placeholder item which can be exchanged, based on user achievements in the online game, for a set of one or more virtual items of value that are usable in the online game, wherein a value of the set of one or more virtual items upon exchange is determined based on user achievements by the first user in the online game;
determine a first quantitative measure of performance achieved during gameplay in the online game, wherein the first quantitative measure of performance involved the first user; and
exchange the placeholder item for the set of one or more virtual items, such that the value of the set of one or more virtual items is increased responsive to the first quantitative measure of performance being greater than a threshold level of performance, and further such that the value of the set of one or more virtual items is decreased responsive to the first quantitative measure of performance being less than the threshold level of performance.

US Pat. No. 10,245,513

INTERFACE-BASED GAME-SPACE CONTEST GENERATION

Kabam, Inc., San Francis...

1. A system for facilitating generation and execution of contests for an online game, wherein the generation includes providing an administrator user interface to an administrator of the contests, and wherein the online game is configured to facilitate interaction of players with the online game and/or each other in response to commands received from client computing platforms associated with the players, the system comprising:one or more processors configured by machine-readable instructions to:
provide the administrator user interface for presentation to the administrator, wherein the administrator user interface is configured to receive user inputs from the administrator that indicate:
(i) one or more performance criteria to be associated with activities performed by the players in the online game, and
(ii) one or more awards to be distributed to the players in association with the one or more contests, wherein the one or more awards include virtual items usable in the online game, and
wherein the players participate in ongoing gameplay within the online game such that the players that participate in the one or more contests continue to participate in the ongoing gameplay during the one or more contests;
determine, based on the performance criteria by the players that participated in the one or more contests, performance scores of the participating players, wherein the activities associated with the one or more performance criteria can be performed by the players in the online game without regard to their participation in the one or more contests such that the activities are performed during the one or more contests by both the players that participated in the one or more contests and by one or more players that did not participate in the one or more contests,
wherein determining the performance scores of the participating players includes monitoring the activities associated with the one or more performance criteria during the one or more contests by the players that participated in the one or more contests, and
wherein the activities associated with the one or more performance criteria that contribute to the determination of the performance scores of the participating players in the one or more contests are the same activities performed by the players to achieve one or more game objectives of the ongoing gameplay outside of the one or more contests; and
automatically distribute the awards to individual ones of the participating players in accordance with the performance scores of the individual participating players.

US Pat. No. 10,245,502

SHUFFLED PLAYING CARDS AND MANUFACTURING METHOD THEREOF

ANGEL PLAYING CARDS CO., ...

1. A method of inspecting one or more shuffled decks of playing cards, wherein each of the one or more shuffled decks of playing cards are shuffled at random, the method comprising the steps of:associating, by a process control system having one or more processors, a shuffled card ID with the one or more shuffled decks of playing cards, wherein the shuffled card ID is unique for the one or more shuffled decks of playing cards packaged in an individual package and the shuffled card ID comprises information about a manufacture or delivery of the one or more shuffled decks of playing cards;
inspecting, by at least one of a card sensor and a camera, each card delivered by a card feeder from the one or more shuffled decks of playing cards; and
determining whether there is a defect in an arrangement of the one or more shuffled decks of playing cards, wherein the step of determining whether there is a defect in the arrangement of the one or more shuffled decks of playing cards comprises determining whether there is a special arrangement in a shuffling of the one or more shuffled decks of playing cards.

US Pat. No. 10,245,500

FLYING SKATEBOARD

JIANGSU DIGITAL EAGLE TEC...

1. A flying skateboard, comprising a bearing part, power parts, a main control module and altitude induction modules; whereinthe bearing part comprises a left foot bearing area and a right foot bearing area configured for bearing a left foot and a right foot of a human body; the left foot bearing area and the right foot bearing area are connected with each other; and the left foot bearing area and the right foot bearing area are configured to rotate oppositely under a pressure generated by pedaling on the left foot bearing area and the right foot bearing area with foot soles of the human body, so that the left foot bearing area and the right foot bearing area are controlled to located on a same plane or different planes;
the power parts are arranged on the periphery of the bearing part and configured for supplying power to the flying skateboard for movement in all directions;
the main control module comprises a gyroscope; and the gyroscope is installed on the bearing part and is configured for controlling a power output of the power parts to keep balance of the flying skateboard and make the flying skateboard to move vertically up and down or hover;
the altitude induction modules are installed on the bearing part, altitude limit threshold values are set in the altitude induction modules, and the altitude induction modules are configured for measuring the distances between the altitude induction modules and the ground; and the altitude induction modules work in cooperation with the power parts to keep the flight altitude of the flying skateboard within the altitude limit threshold value range.

US Pat. No. 10,245,499

TOURING BINDING TO BE FITTED TO A GLIDING BOARD

Salewa Sport AG, Herisau...

1. Front unit of a touring binding, comprising:a bearing arrangement having a bearing element, the bearing element being designed to hold a touring shoe on the front unit on a counter-bearing portion of the touring shoe so as to be pivotable about a transverse axis extending transversely to a glide board longitudinal axis;
a release path being defined on the bearing arrangement, along which path the counter-bearing portion of the touring shoe is configured to exit the bearing arrangement;
a blocking portion designed to:
block a movement of the counter-bearing portion of the touring shoe along the release path when the front unit is in a blocked state; and
allow the movement of the counter-bearing portion of the touring shoe along the release path when the front unit is in a neutral state, wherein, when moving from the neutral state into the blocked state, the blocking portion performs a rotational movement about an axis of rotation of the blocking portion, which axis extends transversely to a glide board longitudinal axis.

US Pat. No. 10,245,492

BASKETBALL SHOOTING TRAINING DEVICE

OnlyNet LLC, Richmond, V...

1. A device for improving basketball shooting form, comprising:an elongated base plate, wherein the base plate has a first end and a second end;
a lower housing assembly secured to the base plate, wherein the lower housing assembly comprises a frame having a set of opposing walls and an apron member secured above the first end of the base plate;
an optical projection device maintained at least partially within the lower housing assembly;
an upper housing assembly secured around the optical projection device;
a finger strap secured to the lower housing assembly for securing to a finger of a user; and
a wrist strap secured to the lower housing assembly for securing to a wrist of the user.

US Pat. No. 10,245,481

GOLF CLUB HEAD

Acushnet Compnay, Fairha...

1. A golf club head comprising:a body having a face, a sole portion, a crown portion and a skirt portion joining the face, sole portion and crown portion;
a hollow golf club interior within the body;
an exterior surface provided opposite the hollow golf club interior;
a plurality of depressions provided on a first portion of the exterior surface of the body;
wherein the plurality of depressions have a depth of about 0.5 mm to about 2 mm, have a width of about 6 mm to about 20 mm and have a minimum landing surface spacing of about 0.5 mm to about 7 mm between depressions on the exterior surface, and
wherein the first portion is provided on at least one of a sole portion or crown portion of the body and further comprises a setback from the face portion of the body, the setback being free of depressions, and wherein the setback has a width of about 6 mm to about 14 mm.

US Pat. No. 10,245,478

GOLF CLUB HEAD

Bridgestone Sports Co., L...

1. A golf club head comprising:a crown portion;
a sole portion;
a face portion; and
a hosel portion,
wherein the crown portion includes a concave portion that starts from a heel-side portion of the face portion which is toward a heel side from a center of the face portion in a toe-heel direction, passes through a boundary portion of the hosel portion and the crown portion on a toe side of the hosel portion, does not pass through a heel side of the hosel portion, and extends toward a back side,
the concave portion includes a range from the face portion toward the back side where a width of the concave portion is larger than a depth of the concave portion,
the concave portion is disposed distant from a center point of the crown on a line extending between the hosel portion and an outermost toe portion of the golf club head,
the range passes on a toe side of the hosel,
the concave portion includes an edge on a side of the face portion, the edge being recessed from an upper edge of the face portion to the sole portion, and
the crown portion does not include, other than the concave portion, a concave portion extending in a face-back direction.

US Pat. No. 10,245,467

PISTON CONFIGURATIONS FOR PNEUMATIC POGO STICK

Vurtego, LLC, Mission Vi...

1. A pogo stick comprising:a housing having a first end and a second end;
a piston disposed within the housing, such that there is an upper confined space between the piston and the first end of the housing; and
a sliding shaft at least partially disposed within the housing, said sliding shaft connected to the piston and extending from the second end of the housing;
wherein the piston comprises:
an upper rim;
a lower surface;
a cylindrical piston body extending between the upper rim and the lower surface; and
a hollowed out volume of space between the upper rim and the lower surface and within the piston body to form a concave structure, the lower surface enclosing a lower end of the hollowed out volume of space;
wherein the upper rim of the piston defines an opening into the hollowed out volume of space facing the first end of the housing such that the hollowed out volume of space within the piston body is in fluid communication with the upper confined space;
wherein a total internal air volume of the housing includes the hollowed out volume of space at both a maximum extension of the piston and at a maximum compression of the piston to reduce a compression ratio of the total internal volume of the housing.

US Pat. No. 10,245,463

METHOD AND SYSTEM FOR AN EXERCISE DEVICE

Custom Product Innovation...

1. An exercise device comprising:a flat base comprising a first end and an opposing second end, said flat base configured to engage a flat exercise surface;
a pair of opposing sidewalls extending away from said flat base;
an arcuate upper surface extending between a first edge of said first end and a second edge of said opposing second end between said pair of opposing sidewalls, a first angle defined between said flat base and said upper surface proximate said first end, a second angle defined between said flat base and said upper surface proximate said opposing second end; and
a first coccyx cutout in said upper surface proximate said first end and extending to said first edge, and a second coccyx cutout in said upper surface proximate said opposing second end and extending to said second edge, wherein said first coccyx cutout extends completely through said exercise device and said second coccyx cutout extends only partially through said exercise device.

US Pat. No. 10,245,454

FIREFIGHTER PROTECTIVE GARMENT HAVING A THERMAL BARRIER WITH SPACERS TO INCREASE DISSIPATION OF METABOLIC HEAT

INNOTEX INC., Richmond (...

1. A firefighter protective coat comprising:a plurality of superimposed layers, the plurality of superimposed layers comprising:
an outer shell defining an outermost layer of the firefighter protective coat;
a moisture barrier inwardly affixed to the outer shell; and
a thermal barrier inwardly affixed to the moisture barrier, the thermal barrier defining an innermost layer of the plurality of superimposed layers; and
an array of spacer pads inwardly affixed to the thermal barrier, the array of spacer pads being configured to maintain a gap between the thermal barrier and a firefighter's body when the firefighter protective coat is worn by the firefighter.

US Pat. No. 10,245,446

MARKER-FLANGE FOR MRI-GUIDED BRACHYTHERAPY

UNIVERSITY OF IOWA RESEAR...

1. A marker-flange for use with a brachytherapy applicator, comprising:a flange body having a first face and a second face, with a hollow chamber positioned in the flange body between the first and second faces;
a cavity comprising a first cavity opening on the first face and a second cavity opening on the second face, the cavity extending through the flange body and dimensioned to receive a tandem in a brachytherapy applicator in a press-fit connection;
a port comprising a port opening positioned on one of the first and second faces of the flange body, the port being configured to communicate with the hollow chamber; and
a sealing agent contained within the port opening, the sealing agent providing an air-tight seal between the hollow chamber and an external environment outside the flange body.

US Pat. No. 10,245,445

INFRARED-RAY LAMP TUBE

Yong-Joo Sin, Yongin-si,...

1. An infrared-ray lamp tube comprising:an elongate tube-shaped housing having an inner space defined therein, wherein the elongate tube-shaped housing have both side open ends;
an infrared-ray emitting array disposed in the inner space, wherein an infrared-ray emitting array includes a plurality of halogen lamp units spacedly arranged in an array in the inner space in a length direction of the elongate tube-shaped housing;
a filtering liquid filling the inner space of the elongate tube-shaped housing;
two plugs respectively fitted into the both side open ends of the elongate tube-shaped housing, and including:
a first plug having an inlet through which the filtering liquid flows into the inner space; and
a second plug opposite to the first plug and having an outlet through which the filter liquid in the inner space flows out; and
a bubble-discharge guide in the inner space in a position adjacent to the outlet, and including:
a front surface facing the first plug, and positioned to conceal the outlet when viewed from the first plug;
an outer circumferential surface spaced apart from an inner surface of the elongate tube-shaped housing with a first gap; and
a rear surface opposite to the front surface, facing the outlet, and spaced apart from an inner wall of the second plug with a second gap being in fluid communication with the first gap such that the filtering liquid in the inner space flows toward the outlet over the front surface through the first pap and the second gap in order.

US Pat. No. 10,245,440

TISSUE TREATMENT APPARATUS AND SYSTEMS WITH PAIN MITIGATION AND METHODS FOR MITIGATING PAIN DURING TISSUE TREATMENTS

SOLTA MEDICAL, INC., Hay...

1. A method of operating a tissue treatment apparatus to transcutaneously treat tissue located beneath a skin surface with electromagnetic energy delivered from a treatment electrode, the method comprising:contacting a first portion of a surface of the treatment electrode with the skin surface, wherein the first portion of the surface of the treatment electrode is exposed through an opening located inside an inner edge of a tip frame;
covering a second portion of the surface of the treatment electrode with the tip frame, wherein the second portion of the surface of the treatment electrode is located between an outer peripheral edge of the tip frame and the inner edge of the opening in the tip frame; and
while maintaining contact between the first portion of the surface of the treatment electrode and the skin surface, transcutaneously delivering the electromagnetic energy from the first portion of the surface of the treatment electrode through the skin surface to the tissue,
wherein the tip frame is composed of an electrically-insulating material.

US Pat. No. 10,245,438

AUTOMATED EXTERNAL DEFIBRILLATOR

NIHON KOHDEN CORPORATION,...

1. An automated external defibrillator comprising:a first pad at least partially colored in a first color;
a second pad at least partially colored in a second color; and
a main unit to which the first pad and the second pad are connected, the main unit comprising a first guidance surface indicating how to attach the first pad and the second pad,
wherein the first guidance surface comprises a first marker comprising an first indicator capable of being turned on and/or blinked in the first color at a position corresponding to an attachment position of the first pad and a second marker comprising a second indicator capable of being turned on and/or blinked in the second color at a position corresponding to an attachment position of the second pad.

US Pat. No. 10,245,437

SYSTEM AND METHOD FOR PROVIDING NONINVASIVE VENTILATION

INOVYTEC MEDICAL SOLUTION...

1. A system configured to assist minimally trained persons to operate it to provide treatment in emergency situations involving respiratory failure and/or cardiac arrhythmias, said system comprising:A) an Airway and Ventilation device (AV) comprising:
i) a face mask;
ii) at least one sensor adapted to monitor vital signs (VS);
iii) a pressurized oxygen source configured to provide a flow of oxygen via said face mask and an airway to a patient and to adjust the oxygen flow on the basis of said monitored vital signs;
B) an Automated External Defibrillator (AED) device comprising one or more electrocardiogram (ECG) detectors that are adapted to be attached to the chest of said patient and are configured to both monitor ECG and to apply electrical shock to said patient via one or more chest pads;
C) a user interface for providing audible or visual instructions to an operator;
D) components that provide communication functionality;
E) a data management unit adapted to operate said system, to provide instructions to the operator, and to record ECG and VS data said data management unit comprising:
i) a processor;
ii) dedicated software; and
iii) memory units;characterized in that the face mask comprises:a) a face attachment unit configured to be attached and secured to the face of a patient by means of connectors that ensure a tight fitting of the face attachment unit to the face contours;
b) a mask body configured to be releasably connected to said face attachment unit by a quick release/attachment mechanism;
wherein said face mask body comprises:
i) a hollow tube that passes from the interior side to the exterior side of said face mask body and is configured to provide a mouth airway securing channel;
ii) a CO2 sensor configured to measure end tidal CO2 (ETCO2) in exhalations of said patient; and
iii) a ventilation tube connected to a portable ventilator configured to deliver air or oxygen to said patient and to remove exhaled air from said patient; and
wherein said quick release/attachment mechanism is configured to allow quick removal of said mask body from said face attachment unit, leaving only the face attachment unit attached by the connectors to the patients' face and leaving the mouth and nose of the patient exposed to the surroundings; and
additionally characterized in that the processor and dedicated software are configured to determine when to apply electric shock according to evaluation of the state of ventilation, wherein the state of ventilation is evaluated according to the ETCO2 measured in each chest compression applied by the operator to the patient.

US Pat. No. 10,245,435

WIRELESS NEURAL STIMULATOR IMPLANTATION

Stimwave Technologies Inc...

1. A method for implanting a neurostimulator system, comprising:inserting an introducer sheath and a needle, carried by the introducer sheath, through an incision site on a patient and into an epidural space of the patient;
withdrawing the needle through the introducer sheath and out of the patient;
after withdrawing the needle out of the patient, inserting the neurostimulator system through the introducer sheath and into the epidural space of the patient, the neurostimulator system comprising an enclosure housing electrodes and at least one passive antenna, the at least one passive antenna configured to receive, via electric radiative coupling, electrical energy and waveform parameters from an antenna located exteriorly to the patient, and the electrodes configured to generate electrical waveforms from the electrical energy and the waveform parameters received at the at least one passive antenna;
advancing the neurostimulator system through the epidural space until the electrodes are positioned adjacent a targeted tissue of the patient so that the electrodes can apply the electrical waveforms to render pain relief therapy to the targeted tissue and in a manner such that a proximal portion of the enclosure remains external to the patient;
removing the introducer sheath from the epidural space of the patient;
removing the proximal portion of the enclosure from the neurostimulator system to leave an implanted portion of the enclosure remaining in the epidural space such that the implanted portion of the enclosure has a customized length that is specific to the patient;
after removing the proximal portion of the enclosure, attaching a cap carrying a radiopaque marker to the implanted portion of the enclosure; and
after attaching the cap to implanted portion of the enclosure, further attaching the cap to a connective tissue at the incision site to anchor the implanted portion of the enclosure to the patient.

US Pat. No. 10,245,434

SYSTEMS, METHODS, AND DEVICES FOR EVALUATING LEAD PLACEMENT BASED ON PATIENT PHYSIOLOGICAL RESPONSES

NUVECTRA CORPORATION, Pl...

1. A method of evaluating a placement of a lead configured to deliver an electrical stimulation therapy for a patient, comprising:programming a pulse generator to generate electrical stimulation to target a sacral nerve or a pudendal nerve of the patient, the electrical stimulation being delivered at least in part via a lead, the electrical stimulation being applied by ramping up a stimulation parameter over time;
detecting, via an observation by a healthcare professional or via feedback provided by the patient, a first physiological response, a second physiological response, and a third physiological response from the patient as a result of the electrical stimulation;
measuring a first value of the stimulation parameter associated with the first physiological response, a second value of the stimulation parameter associated with the second physiological response, and a third value of the stimulation parameter associated with the third physiological response; and
evaluating a placement of the lead inside the patient based on at least one of: a chronological sequence in which the first, second, and third physiological responses occurred, a comparison of the first value with a predetermined threshold, or respective deviations of the second value or the third value from the first value.

US Pat. No. 10,245,430

SIGNAL PROCESSING METHOD FOR COCHLEAR IMPLANT

iMEDI PLUS Inc., Zhubei ...

1. A signal processing method for a cochlear implant, the cochlear implant comprising a microphone and a speech processor, the signal processing method being executed by the speech processor comprising:receiving an electrical speech signal from the microphone;
segmenting the electrical speech signal to a plurality of time-sequenced noisy frames;
reducing noise in each of the plurality of time-sequenced signal frames to obtain a plurality of clean signal frames, the plurality of clean signal frames comprising a (t-1)-th clean frame xt-1 and a t-th clean frame xt;
obtaining a (t-1)-th compression factor ?t-1 according to the (t-1)-th clean frame xt-1;
obtaining a t-th compression factor ?t for the t-th clean frame xt according to the compression factor ?t-1 and the t-th clean frame xt;
obtaining a t-th output frame zt based on the t-th compression factor ?t; and
outputting the t-th output frame zt.

US Pat. No. 10,245,425

ELECTRIC DEVICE FOR MEASURING EEG SIGNAL OR ELECTRIC STIMULATION

YBRAIN INC., Seoul (KR)

1. An electric device for measuring an Electroencephalogram (EEG) signal from a subject's head and for providing electric stimulation to the subject's head, the electric device comprising:a plurality of electrode units configured to be attached to each different position of the head of the subject, and configured to
detect the EEG signal from the subject's head, and
supply electric current to the each different position, each of the plurality of electrode units including a plurality of microelectrodes forming an electric array;
an electric stimulation unit configured to supply electric current in order to provide the electric stimulation to the subject's head;
a switching unit connected to the electric stimulation unit and the plurality of electrode units, and configured to switch
the each of the plurality of electrode units to be selectively connected and
each of the plurality of microelectrodes to be selectively connected; and
a controller connected to the switching unit, and configured to
control the switching unit to be selectively connected to each of the plurality of the electrode units to receive the EEG signal from the subject's head through connected electrode unit among the plurality of electrode units, and
control the switching unit to selectively supply, through the switching unit and the connected electrode unit, the electric current from the electric stimulation unit to the subject's head,
wherein the controller is configured to control the switching unit to supply the electric current from the electric stimulation unit to the subject's head through the each of the plurality of the microelectrodes, and
wherein the controller is configured to
receive a first plurality of EEG signals detected from a first plurality of microelectrodes included in first electrode unit among the plurality of electrode units,
select at least one microelectrode, which is configured to simultaneously receive the EEG signal from the subject's head and supply the electric current to the subject's head, from the first plurality of microelectrodes based on the received first plurality of EEG signals,
receive a first EEG signal from the subject's head through the selected at least one microelectrode among the first plurality of microelectrodes, and
control, at the same time as receiving the first EEG signal, the switching unit to supply the electric current to the subject's head through the selected at least one microelectrode.

US Pat. No. 10,245,422

MICROPROJECTION APPLICATORS AND METHODS OF USE

Corium International, Inc...

1. An applicator, comprising:a rigid planar plate member with an upper surface on a first side of the plate member and a lower surface on a second side of the plate member, the plate member having at least one opening therethrough;
a blocking element in contact with the upper surface of the plate member and being capable of moving between a first position and a second position;
a plunger having a proximal end, a distal end on which at least one microprojection is retained, and a shaft extending therebetween, at least a portion of the proximal end rests directly on and is at least partially retained by the blocking element in its first position; wherein, the plunger is slidably accommodated within the opening of the plate member;
an energy-storing element positioned between the lower surface of the plate member and the distal end of the plunger; and
an actuating member having an external surface for application of a force, and having at least one surface in mechanical communication with the blocking element, wherein the actuating member moves the blocking element from its first position to its second position when a force is applied to the external surface of the actuating member, thereby to effect release of the plunger and the energy-storing element.

US Pat. No. 10,245,418

APPARATUS FOR A MEDICAL SYSTEM INFLATION SYRINGE

Semler Technologies, Inc....

1. A medical system inflation syringe that enables fluid communication selective interconnectability to other medical systems or devices, by means of removable attachment to a female Luer connector that complies to the ISO 594 standard, said syringe comprising at least a plunger and a barrel, a distal end of said barrel further including a barrel lumen and a nozzle, at least one shroud tab, at least one standoff rib, at least one vent, and a nozzle base, wherein:The nozzle further includes at least an insertion outside diameter, a lumen, and a distal opening at the nozzle's distal-most end, the lumen of the nozzle in open communication with the barrel lumen;
The at least one shroud tab is placed circumferentially around and at a distance from the nozzle and enables a friction fit between the interior wall of the at least one shroud tab and an exterior wall of the female Luer connector;
The at least one standoff rib is placed so that it extends radially from the nozzle and nozzle base to the interior wall of the at least one shroud tab;
The at least one vent is placed at the same distance from the nozzle as the at least one shroud tab and has the same height from the distal end of the barrel as said shroud tab;
The at least one vent enables a backflow of air that escapes from the connected female Luer connector that is not a swabable valve, when air is injected from the syringe into said connected female Luer connector against a resistance on the interior side of said female Luer connector;
The insertion outside diameter is located on the nozzle where the distal-most portion of the standoff rib connects to the nozzle and is less than the minimum inside diameter of any female Luer connector compliant to ISO 594 standard;
The at least one standoff rib has a height, measured from the distal end of the barrel so that when said standoff rib: i) comes into contact with the rim of the female Luer connector that is not part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is precluded, and, ii) comes into contact with the rim of the female Luer connector that is part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is established.