US Pat. No. 10,190,867

REAL TIME DUAL MODE FULL-FIELD OPTICAL COHERENCE MICROSCOPY WITH FULL RANGE IMAGING

B. G. NEGEV TECHNOLOGIES ...

1. An interference microscopy 3D imaging system comprising:a. an illumination unit, which provides light to the system;
b. a frequency domain triggering unit, which accepts light from illumination unit and allows triggering of detectors in a frequency domain operating mode;
c. a two beam orthogonally polarized interferometer, which is illuminated by light from illumination unit and;
d. a detection unit comprising:
i. a tube lens;
ii. at least three 50/50 non-polarizing beam splitters;
iii. at least two analyzers;
iv. at least two parallel detectors; and
v. at least one precision achromatic wave plate chosen from at least one of the following types of wave plates: compensating, half wave, and quarter wave; and
e. a motorized stage on which the sample is mounted, the motorized stage connected to and controlled by a processing unit;
wherein the interference microscopy 3D imaging system allows at least two full field achromatic phase shifted interference signals to be captured simultaneously and processed to yield an amplitude signal and a phase signal thereby allowing ultra-high speed, accurate 3D imaging with great immunity to vibrational and intensity noise;
wherein the two beam orthogonally polarized interferometer has the configuration of one of the following interferometer types: Linnik, Michelson, Twyman-Green, Fizau, Nomarski and Mirau.

US Pat. No. 10,190,858

GUN MAGAZINE POUCH ASSEMBLY

1. An assembly for supporting gun magazines comprising:a plurality of pouches, each of said pouches connectable in articulating relationship with another of said pouches by at least one post portion defining a pivot axis about which at least one post receiving portion of a pouch is pivotable, each of said pouches comprising a housing portion adapted to receive a gun magazine therein and each of said housing portions comprising a strap adapter portion constructed and arranged to receive an elongate flexible strap member that is attachable to and detachable from a human body.

US Pat. No. 10,190,842

TOY PROJECTILE LAUNCH SYSTEM

Mattel, Inc., El Segundo...

1. A toy projectile launch system comprising:a launch base comprising
a switch movable between a restricted state and an unrestricted state,
a biasing member configured to bias the switch to the restricted state,
a stop configured to be moved by the switch when the switch is moved from the restricted state to the unrestricted state, and
a trigger assembly separate from the switch and comprising a fixed portion movably coupled to a free portion;
a projectile comprising
a resilient member configured to removably couple the projectile to the launch base; and
a receiving surface configured to receive the stop when the projectile is coupled to the launch base and the switch is in the restricted state; and
an activating device configured to be removably coupled to the launch base;
wherein coupling the activating device to the launch base causes the switch to move to the unrestricted state;
wherein removing the activating device from the launch base causes the biasing member to return the switch to the restricted state;
wherein, when the switch is in the unrestricted state and the projectile is coupled to the launch base, the free portion of the trigger assembly is configured to apply a force to the resilient member and launch the projectile when the free portion is moved with respect to the fixed portion; and
wherein, when the switch is in the restricted state and the projectile is coupled to the launch base, the stop prevents the free portion of the trigger assembly from launching the projectile when the free portion is moved with respect to the fixed portion.

US Pat. No. 10,190,827

CONDENSER AND TURBINE EQUIPMENT

MITSUBISHI HITACHI POWER ...

1. A condenser comprising:a container into which a condensable gas is to flow;
cooling pipes which are positioned inside the container and configured to cool the condensable gas so as to form a condensate;
an extraction air flow path for extracting a noncondensable gas included inside the container;
at least one extraction hole which is defined in the extraction air flow path and through which an interior of the extraction air flow path and an interior of the container communicate with each other; and
at least one cover which is configured with a gap spaced from the extraction air flow path and covers the at least one extraction hole so as to regulate an inflow of the condensate into the at least one extraction hole,
wherein:
the extraction air flow path is composed of an extraction box,
the at least one extraction hole is defined in a side surface of the extraction box which is a vertical surface,
the at least one cover includes an upper cover which protrudes from the side surface of the extraction box above the at least one extraction hole and covers the at least one extraction hole with a gap spaced from the side surface of the extraction box, and a lower cover which protrudes from the side surface of the extraction box below the at least one extraction hole and covers the upper cover with a gap spaced from the upper cover such that the upper cover ends before the lower cover,
the lower cover extends beyond an end of the upper cover, and
the lower cover includes a drain hole for discharging the condensate.

US Pat. No. 10,190,826

CONDENSER FOR CONDENSING STEAM FROM A STEAM TURBINE

MITSUBISHI HITACHI POWER ...

1. A condenser including:a vessel configured to receive a flow of steam in a first direction;
a cooling tube group having an interior hollow portion and disposed inside the vessel, the cooling tube group having a length extending in the first direction, the cooling tube group being formed by arranging a plurality of cooling tube in a second direction which is orthogonal to the first direction;
a non-condensed gas discharge unit provided at a downstream end portion of the cooling tube group along the first direction, wherein the non-condensed gas discharge unit is elongated in the second direction and includes an opening directed toward the hollow portion; and
a partition member extending from the open side of the non-condensed gas discharge unit toward the hollow portion.

US Pat. No. 10,190,823

HIGH TEMPERATURE REACTOR REFRACTORY SYSTEMS

ALLIED MINERAL PRODUCTS, ...

1. A fluidized bed system comprising:(a) a containment vessel;
(b) a precast and predried monolithic refractory floor module positioned in said vessel;
(c) a plurality of precast and predried monolithic refractory wall modules stacked within said vessel, wherein said wall modules are ring-shaped and have inner and outer circumferences, and further wherein said plurality of wall modules includes a first wall module in the form of a unitary ring positioned on said floor module;
(d) a plurality of precast and predried monolithic refractory insulating modules stacked within said vessel and positioned about the outer circumference of said wall modules;
(e) a dry vibratable refractory material located between the outer circumference of said wall modules and said insulating modules; and
(f) a dry vibratable refractory material located between the outer circumference of said insulating modules and said containment vessel;wherein the floor module and said first wall module have interlocking surfaces, and wall modules adjacent to one another have interlocking surfaces.

US Pat. No. 10,190,803

SYSTEM AND METHOD FOR CLEANING SURFACES

Dynamis Solutions, LLC, ...

1. A heliostat comprising:a heliostat mirror surface;
a heliostat cleaning mechanism in cleaning contact with the heliostat mirror surface; and
a heliostat drive system that moves the heliostat mirror surface relative to the cleaning mechanism, removing material from the heliostat mirror surface,
wherein the heliostat cleaning mechanism includes a flexible blade having a longitudinally extending edge in cleaning contact with the mirror surface; and
a blade cleaning device, extending longitudinally in a fixed position along an edge of the heliostat mirror surface, that cleans the heliostat cleaning mechanism.

US Pat. No. 10,190,770

METHOD FOR COOLING SOLID RESIDUES OF A COMBUSTION PROCESS

HITACHI ZOSEN INOVA AG, ...

1. A conveying device, comprising:a conveyor belt with a conveying surface for conveying solid residues; and
means for cooling the solid residues comprising a coolant supply for introducing a gaseous coolant and a coolant evacuation for extracting at least part of the coolant heated by the solid residues, wherein:
the conveyor belt is essentially impermeable to the coolant,
the conveyor belt is an endless conveyor belt that is guided around at least two rollers and forms a loop with a conveying strand and a return strand, the loop together with laterally arranged side walls enclosing a space to which are assigned the coolant supply and the coolant evacuation,
the space between the conveying strand and the return strand is divided with a wall running essentially parallel to a plane of the conveying strand so as to form an interspace between the conveying strand and the wall, the coolant supply and the coolant evacuation being arranged in the interspace or being connected to the interspace, and
the coolant supply and the coolant evacuation are configured such that the coolant is in contact only with a side of the conveyor belt oriented away from the conveying surface.

US Pat. No. 10,190,733

LIGHT SOURCE DEVICE AND ILLUMINATION APPARATUS

SHARP KABUSHIKI KAISHA, ...

1. A light source device comprising:a substrate;
an excitation light source emitting excitation light;
a light emitting section formed by stacking a first layer and a second layer, the first layer including a first phosphor particle which receives the excitation light and emits fluorescence with a first peak wavelength, and the second layer including a second phosphor particle which receives the excitation light and emits fluorescence with a second peak wavelength different from the first peak wavelength; and
an uneven structure that scatters fluorescence and is located at an interface between the first layer and the second layer, wherein
the light emitting section is provided on the substrate,
light including the fluorescence emitted by the first phosphor particle and the fluorescence emitted by the second phosphor particle is emitted as illumination light,
the second layer is closer to the substrate than the first layer is,
the fluorescence emitted by the second layer has a longer peak wavelength than the fluorescence emitted by the first layer, and
the excitation light passes through the substrate so as to be incident on the light emitting section.

US Pat. No. 10,190,698

SOLENOID VALVES FOR HIGH VIBRATION ENVIRONMENTS

Marotta Controls, Inc., ...

1. A solenoid operated valve comprising:a valve block defining a valve lumen;
a poppet slidably disposed within the valve lumen;
a solenoid including a core defining a core lumen aligned with the valve lumen;
an armature assembly including an armature disc, an armature guide having a hollow cylindrical body defining an armature guide passage, and an armature stud disposed within the armature guide passage, wherein at least a portion of the armature guide and at least a portion of the armature stud are disposed within the core lumen, and wherein the armature stud is in communication with the poppet so that axial movement of one is translated into axial movement of the other;
a coil cover enclosing the solenoid; and
a guide ring disposed between the armature guide and the core in a radial direction extending from a central axis of the armature guide passage, wherein the guide ring moves relative to the core when the armature guide moves within the core lumen.

US Pat. No. 10,190,695

CONVERTIBLE CHECK VALVE

Cornell Pump Company, Cl...

1. A convertible check valve comprising:a first valve body section having a first passageway extending therethrough, said first passageway having a first longitudinal axis, said first body section including a first flange at one end thereof, said first flange having a first end surface extending at an angle of 45 degrees to said first longitudinal axis and at which said first passageway terminates, whereupon a shape of said first passageway at said first end surface is elliptical to establish a first elliptical shaped flow port thereat;
a second valve body section having a second passageway extending therethrough, said second passageway having a second longitudinal axis, said second body section including a second flange at one end thereof, said second flange having a second end surface extending at an angle of 45 degrees to said second longitudinal axis and at which said second passageway terminates, whereupon a shape of said second passageway at said second end surface is elliptical to establish a second elliptical shaped flow port thereat, said second end surface of said second flange being configured to be connected to said first end surface of said first flange in either an aligned configuration or an angled configuration, wherein said first and second longitudinal axes are collinear when in said aligned configuration and are perpendicular to each other when in said angled configuration; and
a flapper valve member configured to be moved between a closed state and an opened state, and vice versa, said flapper valve member being configured to close said elliptical flow ports and thereby isolate said second passageway from said first passageway when said flapper valve member is in said closed state, said flapper valve member being configured to open said elliptical flow ports to enable fluid communication between said second passageway and said first passageway through said elliptical flow ports when in said opened state,
wherein said second valve body section additionally comprises a recess to receive the flapper valve member when in the opened state, and
wherein, when positioned within the recess, the flapper valve member is outside an area of a flow path between the first and second elliptical shaped flow ports.

US Pat. No. 10,190,628

MAGNETIC BEARING AND CENTRIFUGAL COMPRESSOR

Green Refrigeration Equip...

1. A magnetic bearing, comprising:a revolving shaft;
an electromagnetic component comprising an iron core with a winding slot, and with coils arranged in the winding slot;
a thrust plate fixed on the revolving shaft; and
a protection mechanism configured to prevent the revolving shaft from colliding with the electromagnetic component;
wherein the electromagnetic component is arranged around an outer periphery of the revolving shaft; a gap is formed between the electromagnetic component and the revolving shaft to provide space for adjusting a position of the revolving shaft; and
wherein the protection mechanism is fixed in the winding slot on the electromagnetic component and arranged around an outer periphery of the thrust plate.

US Pat. No. 10,190,615

ONE PIECE SCREWS FOR, AND METHODS FOR MAKING AND USING, BLIND SIDE FASTENERS AND SYSTEMS WITH FREE SPIN FEATURE

Centrix Aero, LLC, Kent,...

1. A single sided fastener comprising:an auxiliary structure including a housing, a proximal orifice positioned within the housing adjacent to a proximal end of the auxiliary structure, and an axially aligned bore positioned within the housing, where the axially aligned bore includes a first anti-rotation section having a non-circular cross section;
a collet body including a threaded portion and a second anti-rotation section mating with the first-anti-rotation section to prevent rotation between the collet body and the auxiliary structure while allowing axial translation between the collet body and the auxiliary structure, the second anti-rotation section having a non-circular cross-section, the collet body including a plurality of radially displaceable fingers with a plurality of workpiece gripping elements in exterior surfaces of the plurality of radially displaceable fingers;
a screw captively retained in the auxiliary structure and in a first configuration rotationally engaging with the threaded portion of the collet body to transform rotational movement thereof into axial translation of the collet body, wherein the screw includes a screw head with a drive tool interface receiving a rotary force imparted by a drive tool, a screw head flange positioned in the proximal orifice of the auxiliary structure, and a non-threaded portion axially positioned between a distal threaded portion of the screw and a proximal threaded portion of the screw, wherein when the screw is in a second configuration the non-threaded portion is aligned with the threaded portion of the collet body, the screw freely spins within the collet body, and wherein axial translation of the screw initiates interaction between the plurality of radially displaceable fingers and the distal threaded portion of the screw; and
a retaining ring positioned in the auxiliary structure axially retaining the screw head flange.

US Pat. No. 10,190,593

MAGNETIC DRIVE PUMP

ASSOMA INC., Taoyuan (TW...

1. A magnetic drive pump having a pump casing, an impeller, an inner rotor, a stationary shaft, a bracket, a liner and a containment shell;the pump casing made of cast iron or stainless steel being used for containing the impeller, which is for converting shaft power to hydraulic power;
the liner installed on a wetting side inside the pump for isolating a corrosive fluid;
the pump casing comprising a front support, an inlet, a volute, an outlet, a casing back flange and a casing liner;
the casing back flange positioned at a rear end of the pump casing for assembling the bracket and the containment shell;
the front support formed in an inner space of the inlet to be integrated with each other into one piece, the front support extending axially to be a cantilever structure for supporting the stationary shaft mating with the inner rotor to drive the impeller; and the magnetic drive pump being characterized in that:
the front support includes two rib plates, a cone body and a front shaft seat, the front support extends axially toward the inside of the pump casing;
the rib plates extend inward from an inner surface of the inlet of the pump casing and combine together at a center of an inner diameter, combining into a right angle structure where the two ribs are perpendicular to each other;
the cone body is formed at the combination of the two ribs plates and a center of the cone body corresponds to the center of the inner diameter of the inlet of the pump casing; the cone body extends inwardly towards a rear side of the pump casing;
the rib plates extend axially according to an axial length of the cone body and a width of the rib plates of the front support is gradually reduced to match with an outer diameter of the cone body, the cone body passes through a hub aperture of the impeller;
an outer surface of the front support is completely encapsulated with a corrosion resistant plastic and is integrated with the casing liner of the pump casing into one piece;
the impeller is axially shifted a distance with respect to the pump casing, which makes a flow center line of the outlet of the impeller positioned on an inner side of a center line of the outlet of the pump casing, to get a longer flow distance between the inlet of the pump casing and an inlet of the impeller;
a geometry of a shroud curve surface in a vicinity of a blade leading edge of the inlet of the impeller has an adequate radius of curvature, a hub plate near the stationary shaft and in the vicinity of the blade leading edge is a concave design matching with a cone curve surface of the cone body of the front shaft seat;
an inner diameter cylindrical inner surface of the inlet of the pump casing, a shroud curve surface and a shroud surface form a smooth surface with the impeller; the cone body axially extends to the inlet of the impeller with a conic surface, and the cone curve surface and a hub concave surface of a hub surface of the impeller also form a smooth curve surface; and
in the inner space of the inlet of the pump casing has a smooth variation of a cross-sectional area; the corrosive fluid enters the inlet of the pump casing and passes plate leading edges of the rib plates, a flow velocity of the corrosive fluid is increased and a minimum interference is achieved by the longer flow distance, and a flow is rectified by the rib plates.

US Pat. No. 10,190,584

ELECTRIC PUMP

LG INNOTEK CO., LTD., Se...

1. An electric pump comprising:a motor unit including a stator, a rotor core disposed inside the stator, and a shaft coupled to the rotor core;
a first pump unit and a second pump unit which are coupled using the shaft as a coaxial axis;
a first housing in which a motor housing receiving the motor unit and a pump housing including a first pump accommodating part are integrally formed, the first pump unit being inserted in the first pump accommodating part;
a second housing coupled to the first housing to cover the first pump accommodating part and including a second pump accommodating part in which the second pump unit is inserted; and
a cover unit coupled to the second housing to cover the second pump accommodating part,
wherein each of the first pump unit and the second pump unit comprises an internal rotor coupled to the shaft and having an external lob formed thereon and an external rotor disposed outside the internal rotor and having an internal lobe formed to be engaged with the external lob,
wherein the second pump accommodating part is formed on a front face of the second housing and a rear face of the second housing covers the first pump accommodating part,
wherein the first pump accommodating part and the rear face of the second housing have a first-stage inlet port and a first-stage outlet port formed such that the first-stage inlet port and the first-stage outlet port are separated from each other, and
wherein the second pump accommodating part and an inner face of the cover unit have a second-stage inlet port and a second-stage outlet port formed such that the second-stage inlet port and the second-stage outlet port are separated from each other,
wherein the first housing includes a first-stage inlet channel connected to the first-stage inlet port and a first-stage outlet channel connected to the first-stage outlet port, and the second housing includes a second-stage inlet channel passing through the front face and the rear face to cause the first-stage outlet port and the second-stage inlet port to communicate with each other and a second-stage outlet channel connected to the second-stage outlet port.

US Pat. No. 10,190,583

POSITIVE DISPLACEMENT PUMP

MHWIRTH GMBH, Erkelenz (...

1. A positive displacement pump comprising:a drive unit; and
a pump unit comprising,
at least one inline valve unit comprising an external dimension,
four connecting and/or spacing devices, the four connecting and/or spacing devices being arranged in a rectangular shape so that a spacing exists between any two of the four connecting and/or spacing devices, and
a pair of flanges which are connected to each other via the four connecting and/or spacing devices,
wherein,
in an operating position, the at least one inline valve unit is clamped between the pair of flanges,
the at least one inline valve unit is configured to be displaced without removing any of the four connecting and/or spacing devices and without changing a spacing between the pair of flanges and the four connecting and/or spacing devices, and
the spacing between at least two of the four connecting and/or spacing devices is greater than the external dimension of the at least one inline valve unit.

US Pat. No. 10,190,563

INTERNAL COMBUSTION ENGINE IGNITION COIL AND METHOD FOR MANUFACTURING INTERNAL COMBUSTION ENGINE IGNITION COIL

Hitachi Automotive System...

1. An internal combustion engine ignition coil comprising:a central iron core;
a primary coil disposed on an outer circumference of the central iron core;
a secondary coil disposed on an outer circumference of the primary coil;
a side iron core disposed on an outer circumference of the secondary coil; and
an insulating material sealing the central iron core, the primary coil, and the secondary coil on an inner side of the side iron core, wherein
a first layered silicate having a particle diameter less than a winding diameter of the secondary coil is present at a higher concentration in a vicinity of the secondary coil than that in a vicinity of the side iron core in the insulating material,
a second layered silicate having a particle diameter greater than the winding diameter of the secondary coil is present at a higher concentration than that of the first layered silicate between the outer circumference side of the secondary coil and the side iron core, and
the second layered silicate has an aspect ratio of 50 or more, the aspect ratio being a ratio of a long side of a particle of the layered silicate to a thickness of the particle.

US Pat. No. 10,190,538

THRUST REVERSER DEVICE

1. A thrust reverser device for a turbojet engine of an aircraft comprising:a movable cowl;
translating cascades connected to the movable cowl and displaceable between a direct jet position where the translating cascades are retracted in a fan casing, and an indirect jet position where the translating cascades are brought out of the fan casing;
a mast configured to connect the turbojet engine to the aircraft; and
a front suspension configured to suspend the turbojet engine from the mast,
wherein the translating cascades have a sliding connection with the mast via at least one spacer mounted to a sidewall of the mast downstream of the front suspension,
wherein said at least one spacer comprises fixed cascades.

US Pat. No. 10,190,520

SIGNAL CONDITIONING MODULE FOR A WIDE-BAND OXYGEN SENSOR

Harley-Davidson Motor Com...

1. A signal conditioning module for a wide-band oxygen sensor installed in a vehicle, the signal conditioning module comprising:an electronic processor;
a first electrical coupling configured to be coupled to a port of an electrical harness, the port configured to receive an electrical coupling of a narrow-band oxygen sensor for providing power to the narrow-band oxygen sensor, and
a second electrical coupling configured to be coupled to the wide-band oxygen sensor,
wherein the electronic processor receives power over the first electrical coupling, powers the wide-band oxygen sensor over the second electrical coupling using the power received over the first electrical coupling, receives first data over the second electrical coupling from the wide-band oxygen sensor, converts the first data to second data, and outputs the second data over the first electrical coupling to the electrical harness for transmission to an electronic control unit coupled to the electrical harness.

US Pat. No. 10,190,328

CONSTRUCTION SUPPORT

Doka GmbH, Amstetten (AT...

1. A construction support having an axial longitudinal direction, a circumferential direction concentric thereto and a radial direction, the construction support comprising:an outer tube extending in the longitudinal direction;
an inner tube arranged in the outer tube, the inner tube extending in the longitudinal direction and being adjustable in the longitudinal direction relative to the outer tube, the inner tube having an outer thread; and
an adjustment nut having an inner thread,
wherein the outer tube is an uneven rolled tube and is provided with at least one guide groove during a roll-production that extends in the longitudinal direction and is open in the radially inward direction,
wherein the inner tube is a round tube and has at least one radially outwardly protruding guide element that engages into the radially inwardly open guide groove such that the inner tube is thereby interlockingly anti-rotationally arranged in the circumferential direction in the outer tube,
wherein the inner tube is provided with a threaded longitudinal end region that contains the outer thread and an unthreaded longitudinal end region that contains the guide element, and
wherein the adjustment nut is adapted to be screwed to the outer thread of the inner tube and is arranged in a longitudinal end region of the outer tube in a captive manner such that the adjustment nut is rotatable in the circumferential direction,
wherein the adjustment nut is captively held on the outer tube,
wherein the inner tube is adapted to be adjusted in the longitudinal direction relative to the outer tube by rotating the adjustment nut, and
wherein the guide element slides in the guide groove.

US Pat. No. 10,190,295

FAUCET

PANASONIC INTELLECTUAL PR...

1. A faucet comprising:a water outlet for discharging water;
a detector that detects a detection target in a detection area containing a water discharge area in which the water discharged from the water outlet is present; and
a controller operably connected to the detector and the water outlet and that starts and ends supply of the water discharged from the water outlet based on a detection result of the detector,
the detector including
a sensor that sends a radio wave signal and receives the radio wave signal reflected by an object to output a sensor signal corresponding to motion of the object,
a frequency analyzer that applies orthogonal transform to the sensor signal to convert the sensor signal into a frequency domain signal, and extracts, by use of a group of individual filter banks with different frequency bands, signals of the individual filter banks from the frequency domain signal,
a recognizer that performs a recognition process of detecting that the object corresponds to the detection target based on detection data containing at least one of a frequency distribution of signals based on the signals of the individual filter banks and a component ratio of signal intensities based on the signals of the individual filter banks, and
a database device that stores sample data containing at least one of a frequency distribution corresponding to the detection target and a component ratio of signal intensities corresponding to the detection target, and the recognizer performs the recognition process based on comparison between the detection data and the sample data.

US Pat. No. 10,190,283

APPARATUS AND METHOD FOR COUPLING A WORK TOOL TO AN ARM ASSEMBLY OF A MACHINE

Caterpillar Work Tools B....

1. An apparatus for coupling a work tool to an arm assembly of a machine, the arm assembly comprising at least one arm, the apparatus comprising:first engagement means including a first plate fixed to the work tool, an external surface of the first plate spanning a thickness of the first plate defining a forward recess and an aft recess;
second engagement means including a second plate fixed to the work tool, the second plate being spaced apart from the first plate along a first direction, an external surface of the second plate spanning a thickness of the second plate defining a forward recess and an aft recess,
a concavity of each of the forward recess of the first plate, the aft recess of the first plate, the forward recess of the second plate, and the aft recess of the second plate facing a second direction, the second direction being transverse to the first direction;
a first covering member disposed on the first plate and a second covering member disposed on the second plate,
an external surface of the first covering member at least partly defining the forward recess of the first plate,
an external surface of the second covering member at least partly defining the forward recess of the second plate,
an internal surface of the first covering member defining an aperture through the first covering member,
an internal surface of the second covering member defining an aperture through the second covering member;
a third covering member disposed on the first plate and a fourth covering member disposed on the second plate,
an external surface of the third covering member at least partly defining the aft recess of the first plate,
an external surface of the fourth covering member at least partly defining the aft recess of the second plate,
an internal surface of the third covering member defining an aperture through the third covering member,
an internal surface of the fourth covering member defining an aperture through the fourth covering member; and
a first pin that is configured to engage with the at least one arm and the first engagement means,
wherein the first pin is configured to move between an extended position, for engaging with the first engagement means for coupling the work tool to the arm assembly, and a retracted position, for disengaging from the first engagement means for separating the work tool from the arm assembly, and
wherein the first plate and the second plate are disposed between the first covering member and the second covering member along the first direction.

US Pat. No. 10,190,280

DRILL TIP FOR FOUNDATION PILE

Foundation Constructors, ...

1. A drill tip for a foundation pile comprising:a plurality of circular stepped flights formed generally in the shape of a descending continuous conic spiral organized around a center axis, said plurality of flights having a continuous spiral-shaped lower face, a continuous outer face, and a lower end, said outer face intersecting said lower face, said outer face having a lower edge and a continuous spiral flight extending radially outwardly from said lower edge, and the lower end of said plurality of stepped flights including a pilot tip having a generally conical center structure surrounded by a plurality of downwardly extending soil disturbing blades having lowermost portions extending below said conical center structure in a configuration resembling a swiveling fish tail.

US Pat. No. 10,190,275

PAVEMENT SWEEPER WITH CONVEYOR LIFT-OUT DROP-IN SYSTEM

SCHWARZE INDUSTRIES, INC....

1. A motorized wheeled roadway vehicle for sweeping debris from a roadway surface, comprising:a debris receiving container;
a conveyor configured for conveying debris swept from the roadway surface to the debris receiving container, the conveyor having first and second stub shafts, the first stub shaft extending laterally outward from a first side of the conveyor and the second stub shaft extending laterally outward from a second side of the conveyor;
a rotatable broom configured for engagement with the roadway surface to sweep debris therefrom onto the conveyor for conveying the debris to the debris receiving container;
a cradle configured for supporting the conveyor and having first and second stub shaft receiving formations, each formation having a first part connected to the vehicle and having a semi-cylindrical surface configured for receiving the respective stub shaft and having a second removable part having a semi-cylindrical surface, the second removable part and the first part removeably secured together so that the semi-cylindrical surfaces define a bore configured for receiving the respective stub shaft; and
the second removeable parts selectively removeable from the respective first parts to present the stub shafts and the conveyor for removal from the first parts of said formations in a substantially vertical direction.

US Pat. No. 10,190,258

DOCTOR BLADE HOLDERS AND DOCTOR BLADE HOLDER SYSTEMS INCLUDING PLANAR ELEMENTS WITH THREE DIMENSIONAL FABRIC REINFORCEMENT MATERIALS

Kadant Inc., Westford, M...

1. A planar element for use in a papermaking system, said planar element being suitable for use as a doctor blade or a top plate, said planar element comprising:a three-dimensional composite structure including elongated elements extending in at least three orthogonal directions; and
a resin in which the three-dimensional composite structure is embedded.

US Pat. No. 10,190,255

MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PREPARATION AND THEIR USE

DyStar Colours Distributi...

1. A dye mixture comprisingone or more dye(s) of formula (I)

and
one or more dye(s) of formula (II) and/or formula (III)

and optionally
one or more dye(s) of: formula (IV)

wherein D1 and D2 independent of one another is group of formula (1)

wherein
R1 and R2 independent of one another is hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, carboxyl, amido or ureido,
X1 is hydrogen or —SO2—CH?CH2,
D3 and D4 independent of one another is a group of formula (1)
wherein
R1 and R2 independent of one another is hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, carboxyl, amido or ureido,
X1 is hydrogen or a group of the formula: —SO2—Z, wherein
Z is hydroxyl, —CH?CH2 or —CH2CH2Z1, wherein
Z1 is hydroxyl or a group which can be eliminated under the action of alkali,
R200 and R201 independent of one another is
i) hydrogen,
ii) C1-C6-alkyl, which is linear or branched and is unsubstituted or substituted by amino, (C1-C4)-alkylamino, hydroxyl, (C1-C4)-alkoxy, sulfo, halogen, carboxyl, acetamido or ureido;
iii) phenyl which is unsubstituted or substituted by (C1-C4)-alkyl, (C1-C4)-alkoxy, sulfo, halogen, carboxyl, acetamido or ureido;
(iv) amino, (C1-C4)-alkylamino, hydroxyl, (C1-C4)-alkoxy, sulfo, carboxyl, cyano, halogen, nitro, amido or ureido,
R* and R** independent of one another is hydrogen, (C1-C4)-alkyl, CO-(C1-C4-alkyl) or —CH2—SO3M,
M is hydrogen, an alkali metal or one equivalent of an alkaline earth metal
and wherein the sum of weights of all dyes of formula (I) that are present in the dye mixture is at least 40% of the weight of the dye mixture —calculated on the basis of the sum of weights of all dyes according to formulae (I), (II), (III) and (IV) that are present in the dye mixture.

US Pat. No. 10,190,247

WALL-MOUNTED DRUM WASHING MACHINE AND METHOD FOR SENSING MOUNTING ABNORMALITY AND FALL THEREOF

Dongbu Daewoo Electronics...

1. A wall-mounted drum washing machine which includes a buffer member interposed between a through-hole and a wall surface, a rear panel mounted on the wall surface through a fastening member inserted through the through-hole, a tub containing wash water and supported by the rear panel, and a box unit coupled to the rear panel and surrounding the tub, comprising:a sensor configured to sense a contact state between the rear panel and the wall surface;
a control unit configured to determine a mounting abnormality of the drum washing machine, based on the sensed contact state;
a power supply unit configured to control power supply according to the determination result of the control unit; and
a nut member coupled to the fastening member for fixing the rear panel to the wall surface,
wherein the sensor is configured to sense the contact state between the rear panel and the wall surface when the nut member is loosened and moved.

US Pat. No. 10,190,200

ALUMINUM-COPPER-LITHIUM PRODUCTS

CONSTELLIUM ISSOIRE, Iss...

1. A method of manufacturing an extruded product based on an aluminum alloy, said method comprising:a) preparing a liquid metal bath consisting essentially of 2.72 to 3.1% by weight of Cu, 1.59 to 1.8% by weight of Li, 0.1 to 0.5% by weight of Ag, 0.1 to 1.0% by weight of Mg, 0.05 to 0.18% by weight of Zr, 0.2 to 0.6% by weight of Mn, and at least one element selected from Cr, Sc, Hf and Ti, the quantity of said element, if included, being 0.05 to 0.3% by weight for Cr and for Sc, 0.05 to 0.5% by weight for Hf or 0.01 to 0.15% by weight for Ti,
remainder aluminum and inevitable impurities;
b) casting an unwrought shape from said liquid metal bath;
c) homogenizing said unwrought shape at a temperature from 515° C. to 525° C. such that the equivalent time for homogenization

is from 5 to 20 hours, where T (in Kelvin) is the instantaneous treatment temperature, which varies with the time t (in hours), and Tref is a reference temperature set at 793 K;
d) hot working and optionally cold working said unwrought shape into an extruded product;
e) subjecting the product to a solution treatment and quenching;
f) stretching said product with a permanent set of 1 to 5%; and
g) artificially aging said product by heating at 140 to 170° C. for 5 to 70 hours such that said product has a yield strength measured at 0.2% elongation in the L-direction of at least 517 MPa.

US Pat. No. 10,190,190

SYSTEMS AND METHODS FOR MONITORING METAL RECOVERY SYSTEMS

FREEPORT MINERALS CORPORA...

1. A leaching solution monitoring system comprising:a first leaching solution distribution system interface fluidly coupling at least one leaching solution monitoring module to a pipe of a leaching solution distribution system;
a flow meter in fluid communication with the first leaching solution distribution system interface and in fluid communication with a 3-way pressure regulator comprising a 3-way valve;
a transmitter configured to transmit a data to a gateway; and
a processor receiving the data from the gateway,
wherein the leaching solution monitoring system is configured to receive a leaching solution from the first leaching solution distribution system, and allow the leaching solution to be distributed to the leaching solution distribution system.

US Pat. No. 10,190,046

LUMINESCENT-SUBSTANCE MIXTURE, LIGHT-EMITTING SEMICONDUCTOR COMPONENT HAVING A LUMINESCENT-SUBSTANCE MIXTURE, AND STREETLAMP HAVING A LUMINESCENT-SUBSTANCE MIXTURE

OSRAM Opto Semiconductors...

1. A luminescent material mixture having a first luminescent material and a second luminescent material,wherein under excitation with blue light, an emission spectrum of the first luminescent material has a relative intensity maximum in a yellowish-green region of the spectrum at a wavelength of greater than or equal to 540 nm and less than or equal to 560 nm and an emission spectrum of the second luminescent material has a relative intensity maximum in an orange-red region of the spectrum at a wavelength of greater than or equal to 600 nm and less than or equal to 620 nm, and
the second luminescent material is selected from (Ca,Sr,Eu)AlSiN3.Si2N2O or (Ca,Sr,Ba,Eu)2Si5N8 with an Eu content of greater than or equal to 1% and less than or equal to 2.5%, with a Ba content of greater than or equal to 45% and less than or equal to 55% and with a Ca content of greater than or equal to 0% and less than or equal to 10%, wherein the Sr content is selected such that the sum of the Eu, Ba, Ca and Sr contents is 100%.

US Pat. No. 10,190,044

METHOD FOR PRODUCING ?-SIALON FLUORESCENT MATERIAL

NICHIA CORPORATION, Anan...

1. A method for producing a ?-sialon fluorescent material, comprising:providing a composition comprising a material represented by a formula: Si6-zAlzOzN8-z:Eu wherein z satisfies 0 heat-treating the composition in a rare gas atmosphere or in a vacuum; and
contacting the heat-treated composition with a fluorine-containing gas.

US Pat. No. 10,190,041

ENCAPSULATED POROUS PROPPANT

University of Utah Resear...

1. A proppant particle, comprising:a core having a plurality of inner pores;
a shell surrounding the core and including a plurality of shell pores, the shell pores being configured to house a treatment product capable of application to a subterranean formation; and
a polymer encapsulation layer surrounding the shell, the polymer encapsulation layer being permeable to the treatment product such that the treatment product is released over time to an exterior side of the polymer encapsulation layer, the polymer encapsulation layer including a microbial growth solution.

US Pat. No. 10,190,023

SILICA-BASED POLISHING PARTICLE AND ABRASIVE

JGC CATALYSTS AND CHEMICA...

1. A silica-based polishing particle having a three-dimensional polycondensation structure, whereinthe particle contains an alkoxy group therein, the particle having an average particle diameter (d) of 5 to 300 nm, an aspect ratio of 1.00 or more and 1.20 or less, and a carbon content of 0.005% by mass or more and less than 0.50% by mass.

US Pat. No. 10,190,017

PROTECTIVE FILM-FORMING FILM AND METHOD OF MANUFACTURING SEMICONDUCTOR CHIP WITH PROTECTIVE FILM

Lintec Corporation, Toky...

1. A protective film-forming film for forming a protective film which protects a metal film provided on a back surface of a semiconductor chip,wherein the protective film-forming film is formed of a protective film-forming composition to which a coupling agent having a protected thiol group is added, and
wherein the protective group in the protected thiol group includes at least one of the group consisting of a trialkoxysilyl group, a trialkylsilyl group, a trialkylsiloxy group, a carbamate group, a carbonate group, and an acetyl group, and
wherein the coupling agent has a protected thiol group at a terminal of the molecule,
wherein the coupling agent is composed of a compound represented by the following formula (1), and
wherein the protective film-forming composition includes an acrylic resin having a glass transition temperature of ?3 to 6 ° C., and
(R1O)3—Si—X1—S—Y1  formula (1)wherein R1 represents an alkyl group in which three R1s may be the same as or different from each other; X1 represents an alkylene group; and Y1 represents the protective group in the protected thiol group.

US Pat. No. 10,190,009

INK COMPOSITION, INK JET RECORDING METHOD USING SAME, AND COLORED MATERIAL

NIPPON KAYAKU KABUSHIKI K...

1. An ink composition comprising a coloring matter represented by the following formula (3) and a coloring matter represented by the following formula (b4):
wherein the coloring matter represented by formula (3) is from 40% to ? by mass of the total amount of the coloring matters in the ink composition.

US Pat. No. 10,190,008

METHOD FOR PRINTING ON WATER-SOLUBLE MATERIAL

Fujifilm Imaging Colorant...

1. A method for printing on a water-soluble material which comprises the following steps:A) ink jet printing, using a printer with a single-pass print-head, an ink onto a water-soluble material so as to form an image wherein the ink comprises a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a cross-linking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups;
B) overprinting the image formed in step A) with a water soluble overprint varnish.

US Pat. No. 10,189,999

RESIN COMPOSITION FOR COATING AGENT, MOLDED ARTICLE, AND IMAGE DISPLAY DEVICE

JNC CORPORATION, Tokyo (...

1. A resin composition for a coating agent, comprising:a silicon compound (a) represented by formula (I); and
a curable resin (b); and
in formula (I),
R1 is a C3 or C4 alkylene group,
X is a group represented by formula (II) having a urethane skeleton and having a (meth)acryloyl group at an end,
in formula (II),
R2 is hydrogen or a methyl group,
n is an integer of 0 or 1,
a molecular weight of the silicon compound (a) is 500 to 699,

US Pat. No. 10,189,997

COLORANT INCLUDING A MIXTURE OF PIGMENTS

VIAVI Solutions Inc., Sa...

1. A colorant comprising:a first pigment; and
a second pigment,
wherein the second pigment comprises a plurality of layers,
wherein the plurality of layers include a particular layer, and
wherein the particular layer is a reflective ferrochrome (FeCr) layer.

US Pat. No. 10,189,996

ANTHRACENE-BASED ORGANIC DYE

NATIONAL CHI NAN UNIVERSI...

1. An anthracene-based organic dye represented by Formula (1):
wherein
s, m, and n represent independently 0 or 1;
Q is an anchoring group selected from the group consisting of

 wherein X1, X2, X3, X4, X5, X6, X7, and X8 are independently selected from the group consisting of hydrogen, lithium, sodium and

 wherein Z1, Z2, Z3, and Z4 represent independently a C1-C6 alkyl group;
P is an electron acceptor group selected from the group consisting of

 wherein T1, T2, T3, and T4 are independently selected from the group consisting of hydrogen, fluoro, a C4-C12 alkyl group, and a C4-C2 alkoxy group, and T5 is selected from the group consisting of hydrogen and a C4-C17 alkyl group; and
R is an electron donor group with the proviso that
R is selected from the group consisting of

 when s represents 1, and
R is selected from the group consisting of

 when s represents 0,
wherein
Y1, Y2, Y3, Y4, Y9, Y10, Y11, Y12, Y13, Y14, Y15, Y16, Y17, Y18, Y21, Y22, Y23, and Y24 are independently selected from the group consisting of hydrogen and a C4-C12 alkyl group, and
Y5, Y6, Y7, Y8, Y19, and Y20 are independently selected from the group consisting of hydrogen, fluoro, a C4-C12 alkyl group, and a C4-C12 alkoxy group.

US Pat. No. 10,189,994

USE OF A WAX-MODIFIED, AIR RECTIFIED ASPHALT IN BUILT UP ROOFING ASPHALT COMPOSITIONS

Owens Corning Intellectua...

1. A heat stable asphalt composition that meets ASTM D 312 (2006) built-up roofing asphalt (“BURA”) specifications, the heat stable asphalt composition comprising:an air rectified asphalt; and
a wax additive, wherein the additive has a melt point higher than about 100° C.;
wherein the composition has an equiviscous temperature (EVT) of from about 340° F. to about 390° F. for mopping applications and from about 380° F. to about 430° F. for mechanical applications, and wherein the composition has a minimum solubility in trichloroethylene of 99%.

US Pat. No. 10,189,991

HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1 (2H)-ONE COMONOMER UNIT

Polymics, LTD, State Col...

1. A composition, consisting essentially of a melt processable semicrystalline aromatic polyetherketone polymer according to formula (I):
wherein Cp is a phthalazinone unit of formula (II);

Q is a biphenol unit of formula (III);

Z is an aromatic ketone unit of formula (VI);

x is a value of at least 1; and
y is a value of at least 1,
wherein x and y are such that the molar ratio of Q to Cp is between about 30/70 and 90/10,
wherein the polymer has a glass transition temperature between about 180° C. and 240° C., and
wherein the melt processable semicrystalline aromatic polyetherketone polymer has an enthalpy of melting endotherm of between about 5.0 J/g and 26.0 J/g.

US Pat. No. 10,189,990

POLY(PHENYLENE ETHER) COMPOSITION AND ARTICLE

SABIC GLOBAL TECHNOLOGIES...

1. A composition comprising, based on the total weight of the composition:61 to 89 weight percent of a poly(phenylene ether);
3 to 10 weight percent of a polystyrene-poly(ethylene-butylene)-polystyrene triblock copolymer having a polystyrene content of 20 to 40 weight percent and a weight average molecular weight of 200,000 to 400,000 daltons;
6 to 12 weight percent of a flame retardant comprising an organophosphate ester; and
2 to 17 weight percent of an adhesion promoter selected from the group consisting of
(a) phenolic compounds having a molecular weight of 94 to 18,000 daltons;
(b) hydroxysilyl-terminated polydiorganosiloxanes of the formula

 wherein m is 2 to 50, and each occurrence of R1 is independently C1-C12 hydrocarbyl, provided that 5 to 60 mole percent of the occurrences of R1 are independently C6-C12 aryl; and
(c) combinations of the (a) phenolic compounds and the (b) hydroxysilyl-terminated polydiorganosiloxanes.

US Pat. No. 10,189,987

PNEUMATIC TIRE

SUMITOMO RUBBER INDUSTRIE...

1. A pneumatic tire, provided with a tread formed from a rubber composition, the rubber composition comprising:a rubber component,
silica, and
a silane coupling agent represented by Formula (1) below,
the rubber component comprising, based on 100% by mass of the rubber component, 5% to 90% by mass of a conjugated diene polymer containing a constituent unit based on a conjugated diene and a constituent unit represented by Formula (I) below, wherein at least one terminal of the polymer is modified with at least one compound selected from the group consisting of a compound represented by Formula (II) below, a compound containing a group represented by Formula (III) below, a compound represented by Formula (IV) below, a silicon compound containing at least one of a group represented by Formula (V) below or a group represented by Formula (VI) below, and a compound containing a group represented by Formula (VII) below,
the rubber composition comprising the silica in an amount of 5 to 150 parts by mass relative to 100 parts by mass of the rubber component, and
the rubber composition comprising the silane coupling agent represented by Formula (1) in an amount of 2 to 20 parts by mass relative to 100 parts by mass of silica
(CpH2p+1O)3Si—CqH2q—S—CO—CkH2k+1  (1)wherein p represents an integer of 1 to 3; q represents an integer of 1 to 5; and k represents an integer of 5 to 12, andwherein Formulas (I) to (VII) are represented below:
wherein X1, X2, and X3 each independently represent a group represented by Formula (Ia) below, a hydroxy group, a hydrocarbyl group, or a substituted hydrocarbyl group, and at least one of X1, X2, and X3 is a hydroxy group or a group represented by the following Formula (Ia):wherein R1and R2each independently represent a C1-6 hydrocarbyl group, a C1-6 substituted hydrocarbyl group, a silyl group, or a substituted silyl group, and R1and R2may be bonded to each other to form a cyclic structure together with the nitrogen atom,wherein n represents an integer of 1 to 10; R11, R12, and R13each independently represent a C1-4 hydrocarbyl group or a C1-4 hydrocarbyloxy group, and at least one of R11 , R12, and R13 is a hydrocarbyloxy group; and A1 represents a nitrogen atom-containing functional group,wherein p represents an integer of 0 or 1; T represents a C1-20 hydrocarbylene group or a C1-20 substituted hydrocarbylene group; and A2 represents a nitrogen atom-containing functional group,wherein g represents an integer of 1 to 10; R21 represents a hydrogen atom, a C1-6 hydrocarbyl group, or a C1-6 substituted hydrocarbyl group; A3 represents an oxygen atom or the following group: —NR22— where R22 represents a hydrogen atom or a C1-10 hydrocarbyl group; and A4 represents a functional group containing at least one of a nitrogen atom or an oxygen atom,wherein w represents an integer of 1 to 11; and A5 represents a nitrogen atom-containing functional group.

US Pat. No. 10,189,985

POLYACRYLONITRILE (PAN) POLYMERS WITH LOW POLYDISPERSITY INDEX (PDI) AND CARBON FIBERS MADE THEREFROM

CYTEC INDUSTRIES INC., P...

1. A method for synthesizing a polyacrylonitrile (PAN) polymer with a narrow molecular weight distribution, the method comprising:a) combining acrylonitrile (AN) monomer with a solvent, at least one co-monomer, and a thiocarbonylthio compound to form a solution;
b) heating the solution to a temperature within the range of 40° C. 85° C.; and
c) adding an initiator to the heated solution to affect polymerization reaction, thereby forming a polymer solution comprising polyacrylonitrile (PAN) polymer,
wherein polymerization is affected by controlled/living radical polymerization, in which the thiocarbonylthio compound functions as a Reversible Addition/Fragmentation Chain Transfer (RAFT) agent,
wherein the thiocarbonylthio compound is selected from the following structures:

where Z1 is selected from:
—CH2—(CH2)10—CH3; —(CH2)n—CH3, n=0-20;
—C(CH3)m—COOH, m=1-2; —C(CH3)m—COOCH3, m=1-2;
—C(CH3)m—COOC2H5, m=1-2;
R1 is selected from:

R?1 is selected from: —CN;

x=0-1;
R?1 is selected from: H; —CH3; —(CH2)m—COOH, m=1-2;
R??1 is H or —CH3

where Z2 is selected from:

R is selected from: F, Cl, CN, OCH3;
R2 is selected from:

R?2 is selected from: —CN;

x=0-1;
—C(CH3)m—COOCH3, m=1-2;
—C(CH3)m—COOC2H5, m=1-2;
R?2 is selected from: H; —CH3; —(CH2)m—COOH, m=1-2;
R??2 is H or —CH3

where Z3 is selected from: —CH2—(CH2)10—CH3; —(CH2)y—CH3, y=1-20;
R3 is selected from: —CH2—(CH2)10—CH3; —(CH2)y—CH3, y=1-20,
wherein the PAN polymer has a polydispersity index (PDI) of about 2 or less and a molecular weight within the range of 60 kg/mole to 500 kg/mole.

US Pat. No. 10,189,977

PACK FOR ANAEROBIC PRODUCTS

1. A pack comprising:a. a container, the container having a container body; and
b. an anaerobically curable composition held within the container;wherein the container body is constructed from plastics material which is formed from a blend of a thermoplastic starch component, wherein the starch in the thermoplastic starch component is present in an amount from 6% to 33% of the weight of the blend used to form the container body and a polyethylene, and which is sufficiently oxygen permeable to prevent the anaerobically curable composition held therein from curing due to absence of oxygen.

US Pat. No. 10,189,965

PRODUCTION OF VISCOELASTIC POLYURETHANE SYSTEMS USING BLOCK POLYMERS HAVING BONDED SILOXANE BLOCKS AS CELL OPENERS

Evonik Degussa GmbH, Ess...

1. A method of producing a polyurethane foam, said method comprising:foaming a mixture to provide said polyurethane foam, said mixture comprising at least one isocyanate component, at least one polyol component, a blowing agent component comprising water and optionally a physical blowing agent, a stabilizer, and an additive comprising siloxane block polymers of the average general formula (I):
MaM1bDcD1dTeQfGg
with

G are radicals, same or different, selected from the group consisting of:
(O1/2?nSiRm—CH2CHR3—R2—CHR3CH2—SiRm?O1/2)n,
(01/2)n—SiRm—CH2CHR3—R2—CR3?CH2, and
(O1/2?nSiRm—CH2CHR3—R2—CR3?CR3—CH3,
a=1 to 8,
b=1 to 8,
c=3-450,
d=1-30,
e=0-20,
f=0-20,
g=0.15 to 2,
where a+b?2, a+b+c+d+e+f+g=N, and N is ?11 and ?500, and b+d?1,
R are radicals, same or different, having 1-16 carbon atoms or aryl radicals having 6-16 carbon atoms or H or —OR3,
R1 are polyether radicals having a formula (II)

wherein
R4 are alkyl radicals, same or different, which have from 1 to 18 carbon atoms, and optionally have ether functions, or aryl radicals which have from 6-18 carbon atoms and optionally have ether functions, or H,
R5 are radicals, same or different, wherein R5 is selected from the group consisting of: R3, H, and —C(O)R3,
h is from 2 to 18,
i is from 0 to 40,
j is from 1 to 40,
k is from 0 to 40,
l is from 0 to 30,
wherein i+j+k+l?3,
R2 are divalent organic radicals, same or different, which have 2-20 carbon atoms and are optionally interrupted by ether, ester or amide functions or (—SiR2O—)n groups and optionally bear OH functions,
R3 are alkyl radicals, same or different, having 1-16 carbon atoms or aryl radicals having 6-16 carbon atoms or H,
n=independently 1 or 2,
m=independently 1 or 2,
m+n=3,
wherein said at least one polyol component has an average hydroxyl number, determined to DIN 53240-1:2012-07, of greater than 56 to less than 450 mg KOH/g, and wherein said polyurethane foam is produced at an isocyanate index of 65 to 108 and has an open cell structure,
wherein said bonded siloxane block copolymers of the average general formula (I) are present in an amount of from 0.001 to 10 parts by weight per 100 parts of said at least one polyol component, and
wherein said at least one polyol component is present in an amount from 25% to 80% by weight of said mixture, water is present in an amount from 1% to 5% by weight of said mixture, catalysts are present in an amount from 0.01% to 1% by weight of said mixture, said physical blowing agent is present in an amount from 0% to 50% by weight of said mixture, said stabilizer is present in an amount of up to 5% by weight of said mixture, said at least one isocyanate component is present in an amount from 20% to 60% by weight of said mixture, and said additive is present in an amount from 0.001% to 10% by weight of said mixture.

US Pat. No. 10,189,960

RUBBER VIBRATION DAMPING MATERIAL

Dow Global Technologies L...

1. A vulcanized rubber comprised of polyisoprene uniformly crosslinked with a halogenated unsaturated polymer that is a reaction product of (i) an unsaturated polymer that is miscible with polyisoprene and has conjugated dienes that undergo a Diels Alder reaction and (ii) a polyhalogenated cyclopentadiene represented by:wherein X is a fluorine, chlorine or bromine and Y is fluorine, chlorine, bromine or alkoxy having 1 to 4 carbons.

US Pat. No. 10,189,956

POLYMER SUBSTRATES FORMED FROM CARBOXY FUNCTIONAL ACRYLAMIDE

LIFE TECHNOLOGIES AS, Os...

1. A compound of the formula:
wherein R1 is an alkyl group having between 3 and 10 carbons or is a polyether group having between 1 and 10 ether units, wherein R2 is a linear or branched alkyl group having between 3 and 8 carbons or a silyl group, and wherein R3 is hydrogen or an alkyl group having between 1 and 6 carbons.

US Pat. No. 10,189,955

NESTED SUPRAMOLECULAR CAPSULES

CAMBRIDGE ENTERPRISE LIMI...

1. A nested capsule comprising a first capsule held within a second capsule, and each of the first and second capsules has a shell that is a supramolecular cross-linked network, whereineach shell is obtainable from the complexation of a composition comprising a host and one or more building blocks having suitable guest functionality, thereby to form a supramolecular cross-linked network, wherein the second capsule is not provided as a layer on the surface of the first capsule, and the supramolecular cross-linked network includes a non-covalent complex of the host and the one or more building blocks having suitable guest functionality.

US Pat. No. 10,189,953

TEMPERATURE-RESISTANT SILICONE RESINS

THE BOEING COMPANY, Chic...

1. A modified silicone resin of Formula (II):
wherein:
R6, R7, R8, R9, R10, and R11 are each independently selected from a group consisting of H, alkyl, alkenyl, alkynyl, and aryl;
X is selected from the group consisting of arylene, transition metal, cyclosiloxane, silsesquioxane;
t ranges from 1 to 10;
y ranges from 1 to 200; and
z ranges from 1 to 1,000, wherein the resin of Formula (II) has a viscosity ranging from about 500 cSt to about 10,000 cSt.

US Pat. No. 10,189,950

POLYIMIDE-BASED POLYMER THICK FILM COMPOSITIONS

E I DU PONT DE NEMOURS AN...

1. A polyimide-based polymer thick film composition comprising:(a) a non-fluorinated polyimide polymer with the structure I

wherein X is S(O)2 and Y is BAPP and;
(b) an organic solvent with the structure IV

wherein R1=CH3, R2=C(O)OCH3 and R3=H.

US Pat. No. 10,189,949

TRANSPARENT POLYIMIDE COPOLYMER, POLYIMIDE RESIN COMPOSITION AND MOLDED ARTICLE, AND PRODUCTION METHOD OF SAID COPOLYMER

SOMAR CORPORATION, Tokyo...

1. A transparent polyimide copolymer obtained by copolymerizing:(A) 4,4?-oxydiphthalic dianhydride; and
(B) at least one diamine and/or diisocyanate represented by the following Formulae (1) or (2):

(wherein, X represents an amino group or an isocyanate group; R1 to R4 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; and at least one of said R1 to R4 is not a hydrogen atom).

US Pat. No. 10,189,944

SURFACE MODIFICATION METHOD AND SURFACE-MODIFIED ELASTIC BODY

SUMITOMO RUBBER INDUSTRIE...

1. A method for producing a catheter of a rubber vulcanizate or a thermoplastic elastomer, the method comprising:step 1 of forming polymerization initiation points on a surface of the catheter; and
step 2 of radically polymerizing a deliquescent monomer starting from the polymerization initiation points by irradiation with ultraviolet light having a wavelength within the range of 300 to 400 nm, to grow polymer chains on the surface of the catheter,
wherein the deliquescent monomer is at least one selected from the group consisting of alkali metal salt of acrylic acid, alkali metal salt of methacrylic acid, alkali metal salt of itaconic acid, alkali metal salt of 3-vinylpropionic acid, alkali metal salt of 2-sulfoethyl (meth)acrylate, alkali metal salt of 3-sulfopropyl (meth)acrylate, alkali metal salt of 2-acrylamide-2-methylpropanesulfonic acid, and a compound represented by the following formula (1)

wherein R11 represents —H or —CH3; X represents —O—, —NH—, or —N+—; m denotes an integer of one or more; and Y represents a zwitterionic or halogen group.

US Pat. No. 10,189,942

POLYORGANOSILOXANE, POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER, AND PRODUCTION METHOD THEREFOR

IDEMITSU KOSAN CO., LTD.,...

1. A polycarbonate-polyorganosiloxane copolymer, comprising:a polycarbonate block (A) comprising a repeating unit represented by the following general formula (I); and
a polyorganosiloxane block (B) comprising a repeating unit represented by the following general formula (II),
wherein the polyorganosiloxane block (B) has a value obtained by integrating dw/d log(M) from 2.5?log(M)?3.1 is 0 to 10% of a value obtained by integrating dw/d log(M) over the entire range of log (M) in a differential molecular weight distribution curve,
wherein the differential molecular weight distribution curve is determined by gel permeation chromatography using the polystyrene calibration curve, has an x-axis showing a logarithmic value log(M) of a molecular weight M and has a y-axis showing dw/d log(M) obtained by differentiating a concentration fraction w with respect to the logarithmic value log(M) of the molecular weight:

wherein, R9 and R10 each independently represents a halogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms; X represents a single bond, an alkylene group having 1 to 8 carbon atoms, an alkylidene group having 2 to 8 carbon atoms, a cycloalkylene group having 5 to 15 carbon atoms, a cycloalkylidene group having 5 to 15 carbon atoms, a fluorenediyl group, an arylalkylene group having 7 to 15 carbon atoms, an arylalkylidene group having 7 to 15 carbon atoms, —S—, —SO—, —SO2—, —O—, or —CO—; a and b each independently represents an integer of 0 to 4; R1 and R2 each independently represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or an aryl group having 6 to 12 carbon atoms; an average repeat number n in the range of 30 to 50 represents a sum of siloxane repeating units in the polyorganosiloxane block.

US Pat. No. 10,189,939

HIGH PERFORMANCE EXTENDED POT LIFE EPOXY HARDENERS

ANGUS CHEMICAL COMPANY, ...

1. A method for curing an epoxy resin; said method comprising adding to the epoxy resin a curing agent comprising a compound of formula (I)
wherein:
X is a difunctional group selected from C3-C10 alkyl and C4-C20 heteroalkyl having only oxygen heteroatoms.

US Pat. No. 10,189,931

GRAFT POLYMER AND METHOD FOR PRODUCING SAME

NITTO BOSEKI CO., LTD., ...

1. A polyamine graft polymer obtained by polymerizing a polyamine derivative obtained by a reaction between (a) a polymer compound having at least one amino group and (b) a compound having at least one epoxy group; and (c) an ethylenically unsaturated monomer,wherein the polymer compound having at least one amino group (a) is selected from the group consisting of an ethyleneimine (co)polymer having a structure represented by general formula (1), a vinylamine (co)polymer having a structure represented by general formula (2), an allylamine (co)polymer having a structure represented by general formula (3), a diallylamine (co)polymer having a structure represented by general formula (4), and an acrylic amine (co)polymer having a structure represented by general formula (5) (in the following general formulae, n is an integer of from 10 to 200000, m is an integer of from 5 to 18000, 1 is an integer of from 5 to 15000, o is an integer of from 10 to 10000, and p is an integer of from 1 to 100)

and wherein the ethylenically unsaturated monomer (c) is selected from the group consisting of a vinyl monomer, a styrene monomer, a methacrylate monomer, an acrylate monomer, an acrylamide monomer, an allyl monomer, a diallyl monomer, and an unsaturated carboxylic acid.

US Pat. No. 10,189,930

POLYMERIC PHOTOINITIATORS

ALLNEX BELGIUM S.A., Dro...

1. A radiation curable composition (A) comprising,(a) at least one photoinitiator compound of formula (I):

wherein Q is the residue of a hydroxy compound having 1 to 6 hydroxyl groups,
wherein x is a number that is at least 1 but no greater than the number of hydroxyl groups originally present in said hydroxy compound, and
wherein the hydroxy compound is a saturated hydroxy compound having 1 to 6 hydroxyl groups and is selected from the group consisting of an alkoxylated alcohol and a polyether; and
(b) at least one ethylenically unsaturated compound selected from the group consisting of monomers (b1) and oligomers (b2).

US Pat. No. 10,189,927

IONOMER HAVING HIGH OXYGEN PERMEABILITY

DAIKIN INDUSTRIES, LTD., ...

1. An ionomer, comprising:a repeating unit A;
a repeating unit B, and
a repeating unit C,
the ionomer having an equivalent weight of 250 to 930 and a glass transition temperature of 100° C. to 130° C.,
the amount of the repeating unit B is 16 to 45 mol %, relative to all the repeating units,
the repeating unit B being represented by the formula (2):
wherein Rp represents a monovalent group having a proton exchange group,wherein the repeating unit A is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (3):
wherein m3 represents an integer of 2 to 6; anda repeating unit represented by the formula (4):
wherein Y41 represents F or a C1-C3 perfluoroalkyl group; k4 represents 0 or 1; n4 represents an integer of 1 to 8; when n4 represents an integer of 2 to 8, Y41 in each of respective units —(CF2CFY41—O)n4— may be the same as or different from each other; and m4 represents an integer of 1 to 6,wherein the repeating unit C that is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (7):
wherein Rf71 represents F, Cl, or a C1-C9 linear or branched fluoroalkyl group, anda repeating unit represented by the formula (8):
wherein Y81 represents H or F; Y82 represents F or a C1-C9 linear or branched fluoroalkyl group;and Y83 represents H, F, Cl, or a C1-C9 linear or branched fluoroalkyl group.

US Pat. No. 10,189,925

RAPID CURE POLYMERIC RESINS

THE BOEING COMPANY, Chic...

1. A polymer of formula (I):
wherein:
each instance of R1 is —C1-5—O—C1-5—O—C1-5—;
each instance of R2 is the same or different and is selected from

 each instance of R24 is independently selected from hydrogen, alkyl, or alkoxy;
“Linker” is of formula (II):

c is less than 1.0;
d is 0 when c is 0; and
a+b+d is from about 7 to about 38.

US Pat. No. 10,189,923

PRODUCING POLYOLEFIN PRODUCTS

Univation Technologies, L...

1. A method of polymerizing olefins within a polymerization reactor to produce a polyolefin polymer with a multimodal composition distribution, comprising contacting ethylene and a comonomer with a catalyst system, wherein the catalyst system comprises a first catalyst compound and a second catalyst compound that are co-supported to form a commonly supported catalyst system, wherein the first catalyst compound comprises the following formula:(C5HaR1b)(C5HcR2d)HfX2
wherein each R1 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; each R2 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; a and c are ?3; a+b=c+d=5; at least one R1 and at least one R2 is a hydrocarbyl or substituted hydrocarbyl group; adjacent groups R1 and R2 groups are optionally coupled to form a ring; and each X is independently a leaving group selected from a labile hydrocarbyl, substituted hydrocarbyl, or heteroatom group, or a divalent radical that links to an R1 or R2 group; and the second catalyst compound comprises the following formula:

wherein each R3 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; R4 is a hydrocarbyl group, a substituted hydrocarbyl group, or a heteoatom group; each R5 is independently H, a hydrocarbyl group, a substituted hydrocarbyl group, or a heteroatom group; wherein R3, R4, and R5 are the same or different; and each X is independently a leaving group selected from a labile hydrocarbyl, a substituted hydrocarbyl, a heteroatom group, or a divalent radical that links to an R3, R4, or R5 group.

US Pat. No. 10,189,921

RADICAL POLYMERISATION OF ETHYLENE INITIATED BY A COUPLE OF ORGANIC PEROXIDES WITH HIGH PRODUCTIVITY

ARKEMA FRANCE, Colombes ...

1. A process for manufacturing polyethylene or an ethylene copolymer, comprising radical polymerization or copolymerization of ethylene in the presence:of a first peroxide polymerization initiator chosen from the diperketal peroxide compounds of formula:

wherein the R1, R2, R3, R6, R7 and R8 groups comprise substituted or unsubstituted, linear, branched or cyclic C1-C10 alkyl groups, and
of a second initiator, other than said first initiator, also comprising a diperketal peroxide of formula (I).

US Pat. No. 10,189,920

HYBRID SUPPORTED CATALYST SYSTEM AND METHOD OF PREPARING POLYOLEFIN USING THE SAME

LG Chem, Ltd., Seoul (KR...

1. A hybrid supported catalyst system comprising;one or more organic chromium compounds and one or more metallocene compounds supported on a support,
wherein the organic chromium compound includes two or more of a group represented by the following Chemical Formula 1 in a molecule, phosphorous atoms (P) in one or more of the group represented by Chemical Formula 1 form a coordinate bond with chromium (Cr), and a linkage group (L) linking the two or more groups represented by the following Chemical Formula 1 via 4 to 8 carbon atoms is an aliphatic group having 2 to 20 carbon atoms, a heteroaliphatic group having 2 to 20 carbon atoms, an alicyclic group having 2 to 20 carbon atoms, a heteroalicyclic group having 2 to 20 carbon atoms, or a group prepared by linking two or more of the aliphatic group, the heteroaliphatic group, the alicyclic group, and the heteroalicyclic group:

wherein * is a part which binds to the linkage group (L) linking the two or more groups, and
R1 to R4 are each independently an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, or an alkoxyaryl group having 7 to 20 carbon atoms.

US Pat. No. 10,189,916

TRANSITION METAL COMPOUND AND CATALYST COMPOSITION INCLUDING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A transition metal compound of the following Chemical Formula 1:
wherein, in Chemical Formula 1,
M is a group 4 transition metal;
R is selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, and an alkylaryl group having 7 to 20 carbon atoms; or R and R1 are linked to each other to form an aliphatic ring having 3 to 20 carbon atoms or an aromatic ring having 5 to 20 carbon atoms including N;
R1 to R10 are each independently selected from the group consisting of a hydrogen atom, a halogen group, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, an aryloxy group having 6 to 20 carbon atoms, a silyl group and combinations thereof, or two or more adjacent functional groups among R1 to R10 are linked to each other to form an aliphatic ring having 3 to 20 carbon atoms or an aromatic ring having 6 to 20 carbon atoms;
R11 is selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, a silyl group, and a metalloid radical of a group 14 metal substituted with a hydrocarbyl group having 1 to 20 carbon atoms;
X1 and X2 are each independently selected from the group consisting of a halogen group, an alkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylamino group having 1 to 20 carbon atoms, an arylamino group having 6 to 20 carbon atoms and an alkylidene group having 1 to 20 carbon atoms;
R, R1 to R11, X1 and X2 are each independently unsubstituted or substituted with one or more substituents selected from the group consisting of a halogen group, an alkyl group having 1 to 20 carbon atoms, a haloalkyl group having 1 to 20 carbon atoms, an alkenyl group having 2 to 20 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, an aryl group having 6 to 20 carbon atoms, an arylalkyl group having 7 to 20 carbon atoms, an alkylaryl group having 7 to 20 carbon atoms and an aryloxy group having 6 to 20 carbon atoms;
n is an integer of 1 or 2, and when n is an integer of 2, R11's are the same as or different from each other; and
wherein a dashed line to the cyclopentadienyl ring represents an ?5-complex with the cyclopentadienyl ring, and a solid line to the cyclopentadienyl ring represents a ?-bond to a carbon of the cyclopentadienyl ring.

US Pat. No. 10,189,913

BIOPOLYMERS HAVING COILED NANOSTRUCTURES AND PROCESSES INCORPORATING THE BIOPOLYMERS

BIOPOLYNET INC., Frederi...

1. A process for preparing iron ore pellets comprising:combining crushed iron ore with bentonite and a first aqueous solution, the first aqueous solution having a first binder comprising one or more first biopolymers having coiled nanostructures to form a mixture;
shaping the mixture into a pellet; and
spraying the pellet with a second aqueous solution, the second aqueous solution containing at least one second biopolymer having a coiled nanostructure that is configured to react with an agent in the first aqueous solution to cause the one or more first biopolymers to undergo cross-linking to form a biopolymeric network in order to prepare a green ball.

US Pat. No. 10,189,894

RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR

Adimab, LLC, Lebanon, NH...

1. An antibody isolated from a library comprising synthetic polynucleotides that encode an antibody heavy chain and an antibody light chain containing at least about 106 unique antibody CDRH3 amino acid sequences, wherein each of the polynucleotides encoding the at least about 106 unique antibody CDRH3 amino acid sequences has an antibody CDRH3 amino acid sequence represented by the following formula:[X]-[N1]-[DH]-[N2]-[H3-JH], wherein
(i) X is selected from the group consisting of G, D, E and nothing;
(ii) N1 is an amino acid sequence selected from the group consisting of G, P, R, A, S, L, T, V, GG, GP, GR, GA, GS, GL, GT, GV, PG, RG, AG, SG, LG, TG, VG, PP, PR, PA, PS, PL, PT, PV, RP, AP, SP, LP, TP, VP, IG, KG, GW, FP, EG, GGG, GPG, GRG, GAG, GSG, GLG, GTG, GVG, PGG, RGG, AGG, SGG, LGG, TGG, VGG, GGP, GGR, GGA, GGS, GGL, GGT, GGV, D, E, F, H, I, K, M, Q, W, Y, AR, AS, AT, AY, DL, DT, EA, EK, FH, FS, HL, HW, IS, KV, LD, LE, LR, LS, LT, NR, NT, QE, QL, QT, RA, RD, RE, RF, RH, RL, RR, RS, RV, SA, SD, SE, SF, SI, SK, SL, SQ, SR, SS, ST, SV, TA, TR, TS, TT, TW, VD, VS, WS, YS, AAE, AYH, DTL, EKR, ISR, NTP, PKS, PRP, PTA, PTQ, REL, RPL, SAA, SAL, SGL, SSE, TGL, WGT;
(iii) DH is all of a human CDRH3 DH amino acid sequence, wherein the DH amino acid sequence is selected from the group consisting of ATT, GAT, GIV, IVG, VGA, VLLLWLLL (SEQ ID NO: 239), ITMIVVVIT (SEQ ID NO: 240), VQWLV (SEQ ID NO: 241), VQQLV (SEQ ID NO: 242), VLRFLEWLLY (SEQ ID NO: 243), YYDFWSGYYT (SEQ ID NO: 244), WILYQLLC (SEQ ID NO: 245), LRL (SEQ ID NO: 246), TTVT (SEQ ID NO: 247), VWELL (SEQ ID NO: 248), VDTAMVT (SEQ ID NO: 249), WIQLWL (SEQ ID NO: 250), RILWWLLL (SEQ ID NO: 251), DIVVVVAAT (SEQ ID NO: 252), VLLLWFG (SEQ ID NO: 595), GATT (SEQ ID NO: 623), GIVG (SEQ ID NO: 624), IVGA (SEQ ID NO: 625), VGAT (SEQ ID NO: 626), GIVGA (SEQ ID NO: 627), IVGAT (SEQ ID NO: 628), VGATT (SEQ ID NO: 629), GIVGAT (SEQ ID NO: 630), IVGATT (SEQ ID NO: 631), GIVGATT (SEQ ID NO: 13), YSG, YSGS (SEQ ID NO: 632), YSGSY (SEQ ID NO: 633), YSGSYY (SEQ ID NO: 14), CSSTSC (SEQ ID NO: 622), CSSTSCY (SEQ ID NO: 620), YCSSTSC (SEQ ID NO: 621), CSSTSCYT (SEQ ID NO: 617), GYCSSTSC (SEQ ID NO: 618), YCSSTSCY (SEQ ID NO: 619), GYCSSTSCY (SEQ ID NO: 615), YCSSTSCYT (SEQ ID NO: 616), GYCSSTSCYT (SEQ ID NO:10), AAM, DIV, IVY, PAA, VPA, VVP, VVV, DIVV (SEQ ID NO: 634), IVVV (SEQ ID NO: 635), PAAM (SEQ ID NO: 636), VPAA (SEQ ID NO: 637, VVPA (SEQ ID NO: 638), VVVP (SEQ ID NO: 639), DIVVY (SEQ ID NO: 640), IVVVP (SEQ ID NO: 641), VPAAM (SEQ ID NO: 642), VVPAA (SEQ ID NO: 643), VVVPA (SEQ ID NO: 644), DIVVVP (SEQ ID NO: 645), IVVVPA (SEQ ID NO: 646), VVPAAM (SEQ ID NO: 647), VVVPAA (SEQ ID NO: 648), DIVVVPA (SEQ ID NO: 649), IVVVPAA (SEQ ID NO: 650), VVVPAAM (SEQ ID NO: 651), DIVVVPAA (SEQ ID NO: 652), IVVVPAAM (SEQ ID NO: 653), DIVVVPAAM (SEQ ID NO: 11), CSGGSC (SEQ ID NO: 654), CSGGSCY (SEQ ID NO: 655), YCSGGSC (SEQ ID NO: 656), CSGGSCYS (SEQ ID NO: 657), GYCSGGSC (SEQ ID NO: 658), YCSGGSCY (SEQ ID NO: 659), GYCSGGSCY (SEQ ID NO: 660), YCSGGSCYS (SEQ ID NO: 661), GYCSGGSCYS (SEQ ID NO: 16), FGV, GVV, IFG, ITI, TIF, VVI, FGVV (SEQ ID NO: 662) , GVVI (SEQ ID NO: 663), IFGV (SEQ ID NO: 664), ITIF (SEQ ID NO: 665) , TIFG (SEQ ID NO: 666), VVII (SEQ ID NO: 667), FGVVI (SEQ ID NO: 668), GVVII (SEQ ID NO: 669), IFGVV (SEQ ID NO: 670), ITIFG (SEQ ID NO: 671), TIFGV (SEQ ID NO: 672), FGVVII (SEQ ID NO: 673), IFGVVI (SEQ ID NO: 674), ITIFGV (SEQ ID NO: 675), TIFGVV(SEQ ID NO: 676), IFGVVII (SEQ ID NO: 677), ITIFGVV (SEQ ID NO: 678), TIFGVVI (SEQ ID NO: 679), ITIFGVVI (SEQ ID NO: 680), TIFGVVII(SEQ ID NO: 681), ITIFGVVII (SEQ ID NO: 9), ELL, FGE, GEL, LLW, LWF, VLL, WFG, FGEL (SEQ ID NO: 682), GELL (SEQ ID NO: 683), LLWF (SEQ ID NO: 684), LWFG (SEQ ID NO: 685), VLLW (SEQ ID NO: 686), WFGE (SEQ ID NO: 687), FGELL (SEQ ID NO: 688), LLWFG (SEQ ID NO: 689), LWFGE (SEQ ID NO: 690), VLLWF (SEQ ID NO: 691), WFGEL (SEQ ID NO: 692), LLWFGE (SEQ ID NO: 693), LWFGEL (SEQ ID NO: 694), VLLWFG (SEQ ID NO: 695), WFGELL (SEQ ID NO: 696), LLWFGEL (SEQ ID NO: 697), LWFGELL (SEQ ID NO: 698), VLLWFGE (SEQ ID NO: 699), LLWFGELL (SEQ ID NO: 700), VLLWFGEL (SEQ ID NO: 701), VLLWFGELL (SEQ ID NO: 1), GSG, GSY, SGS, SYY, YGS, YYG, YYN, YYY, GSGS (SEQ ID NO: 702), GSYY (SEQ ID NO: 703), SGSY (SEQ ID NO: 704) , SYYN (SEQ ID NO: 705), YGSG (SEQ ID NO: 706), YYGS (SEQ ID NO: 707), YYYG (SEQ ID NO: 708), GSGSY (SEQ ID NO: 709), GSYYN (SEQ ID NO: 710), SGSYY (SEQ ID NO: 711), YGSGS (SEQ ID NO: 712), YYGSG (SEQ ID NO: 713), YYYGS (SEQ ID NO: 714), GSGSYY (SEQ ID NO: 715), SGSYYN (SEQ ID NO: 716), YGSGSY (SEQ ID NO: 717), YYGSGS (SEQ ID NO: 718), YYYGSG (SEQ ID NO: 719), GSGSYYN (SEQ ID NO: 720), YGSGSYY (SEQ ID NO: 721), YYGSGSY (SEQ ID NO: 722), YYYGSGS (SEQ ID NO: 723), YGSGSYYN (SEQ ID NO: 724), YYGSGSYY (SEQ ID NO: 725), YYYGSGSY (SEQ ID NO: 726), YYGSGSYYN (SEQ ID NO: 727), YYYGSGSYY (SEQ ID NO: 728), YYYGSGSYYN (SEQ ID NO: 2), GVI, ITM, MVR, RGV, TMV, VII, VRG, GVII (SEQ ID NO: 729), ITMV (SEQ ID NO: 730), MVRG (SEQ ID NO: 731), RGVI (SEQ ID NO: 732), TMVR (SEQ ID NO: 733), VRGV (SEQ ID NO: 734), ITMVR (SEQ ID NO: 735), MVRGV (SEQ ID NO: 736), RGVII (SEQ ID NO: 737), TMVRG (SEQ ID NO: 738), VRGVI (SEQ ID NO: 739), ITMVRG (SEQ ID NO: 740), MVRGVI (SEQ ID NO: 741), TMVRGV (SEQ ID NO: 742), VRGVII (SEQ ID NO: 743), ITMVRGV (SEQ ID NO: 744), MVRGVII (SEQ ID NO: 745), TMVRGVI (SEQ ID NO: 746), ITMVRGVI (SEQ ID NO: 747), TMVRGVII (SEQ ID NO: 748), ITMVRGVII (SEQ ID NO: 3), DSS, GYY, SGY, SSG, YDS, YYD, DSSG (SEQ ID NO: 749), GYYY (SEQ ID NO: 750), SGYY (SEQ ID NO: 751), SSGY (SEQ ID NO: 752), YDSS (SEQ ID NO: 753), YYDS (SEQ ID NO: 754), YYYD (SEQ ID NO: 755), DSSGY (SEQ ID NO: 756), SGYYY (SEQ ID NO: 757), SSGYY (SEQ ID NO: 758), YDSSG (SEQ ID NO: 759), YYDSS (SEQ ID NO: 760), YYYDS (SEQ ID NO: 761), DSSGYY (SEQ ID NO: 762), SSGYYY (SEQ ID NO: 763, YDSSGY (SEQ ID NO: 764), YYDSSG (SEQ ID NO: 765), YYYDSS (SEQ ID NO: 766), DSSGYYY (SEQ ID NO: 767), YDSSGYY (SEQ ID NO: 768), YYDSSGY (SEQ ID NO: 769), YYYDSSG (SEQ ID NO: 770), YDSSGYYY (SEQ ID NO: 771), YYDSSGYY (SEQ ID NO: 772), YYYDSSGY (SEQ ID NO: 773), YYDSSGYYY (SEQ ID NO: 774), YYYDSSGYY (SEQ ID NO: 775), YYYDSSGYYY (SEQ ID NO: 4), DYG, GDY, YGD, DYGD (SEQ ID NO: 613), YGDY (SEQ ID NO: 614), DYGDY (SEQ ID NO: 12), SYG, YGY, YSY, GYSY (SEQ ID NO: 776), SYGY (SEQ ID NO: 777), YSYG (SEQ ID NO: 778), GYSYG (SEQ ID NO: 779), YSYGY (SEQ ID NO: 780), GYSYGY (SEQ ID NO: 15), SSS, SSW, SWY, SSSW (SEQ ID NO: 781), SSWY (SEQ ID NO: 782), YSSS (SEQ ID NO: 783), GYSSS (SEQ ID NO: 784), SSSWY (SEQ ID NO: 785), YSSSW(SEQ ID NO: 786), GYSSSW (SEQ ID NO: 787), YSSSWY (SEQ ID NO: 788), GYSSSWY (SEQ ID NO: 7) , GWY, GYS, SGW, YSS, GYSS (SEQ ID NO: 789), SGWY (SEQ ID NO: 790), SSGW (SEQ ID NO: 791), YSSG (SEQ ID NO: 792), GYSSG (SEQ ID NO: 793), SSGWY (SEQ ID NO: 794), YSSGW (SEQ ID NO: 795), GYSSGW (SEQ ID NO: 796), YSSGWY (SEQ ID NO: 797), GYSSGWY (SEQ ID NO: 5), AVA, GIA, IAV, VAG, AVAG (SEQ ID NO: 798), GIAV (SEQ ID NO: 799), IAVA (SEQ ID NO: 800), GIAVA (SEQ ID NO: 801), IAVAG (SEQ ID NO: 802), GIAVAG (SEQ ID NO: 6), AAA, AAG, IAA, AAAG (SEQ ID NO: 803), GIAA (SEQ ID NO: 804), IAAA (SEQ ID NO: 805), GIAAA (SEQ ID NO: 806), IAAAG (SEQ ID NO: 807), and GIAAAG (SEQ ID NO: 8);
(iv) N2 is an amino acid sequence selected from the group consisting of G, P, R, A, S, L, T, V, GG, GP, GR, GA, GS, GL, GT, GV, PG, RG, AG, SG, LG, TG, VG, PP, PR, PA, PS, PL, PT, PV, RP, AP, SP, LP, TP, VP, IG, KG, GW, FP, EG, GGG, GPG, GRG, GAG, GSG, GLG, GTG, GVG, PGG, RGG, AGG, SGG, LGG, TGG, VGG, GGP, GGR, GGA, GGS, GGL, GGT, GGV, D, E, F, H, I, K, M, Q, W, Y, AR, AS, AT, AY, DL, DT, EA, EK, FH, FS, HL, HW, IS, KV, LD, LE, LR, LS, LT, NR, NT, QE, QL, QT, RA, RD, RE, RF, RH, RL, RR, RS, RV, SA, SD, SE, SF, SI, SK, SL, SQ, SR, SS, ST, SV, TA, TR, TS, TT, TW, VD, VS, WS, YS, AAE, AYH, DTL, EKR, ISR, NTP, PKS, PRP, PTA, PTQ, REL, RPL, SAA, SAL, SGL, SSE, TGL, WGT;
(v) H3-JH is all of a human CDRH3 H3-JH amino acid sequence, wherein the H3-JH amino acid sequence is selected from the group consisting of AEYFQH (SEQ ID NO: 17), EYFQH (SEQ ID NO: 583), YFQH (SEQ ID NO: 584), FQH, QH, H YWYFDL (SEQ ID NO: 18), WYFDL (SEQ ID NO: 585), YFDL (SEQ ID NO: 586), FDL, DL, L, AFDV (SEQ ID NO: 19), FDV, DV, V, YFDY (SEQ ID NO: 20), FDY, DY, Y, NWFDS (SEQ ID NO: 21), WFDS (SEQ ID NO: 587), FDS, DS, S, YYYYYGMDV (SEQ ID NO: 22), YYYYGMDV (SEQ ID NO: 588), YYYGMDV (SEQ ID NO: 589), YYGMDV (SEQ ID NO: 590), YGMDV (SEQ ID NO: 591), GMDV (SEQ ID NO: 592), MDV, AFDI (SEQ ID NO: 852), FDI, DI, NWFDP (SEQ ID NO: 857), WFDP (SEQ ID NO: 858), FDP, and DP;
wherein the diversity of the polynucleotides encoding the at least about 106 unique antibody CDRH3 amino acid sequences is created by each of the polynucleotides having a CDRH3 sequence that is different from the CDRH3 sequence of every other polynucleotide;
wherein the antibody heavy chain is a variable domain with framework (FRM) and complementary determining regions (CDR) comprising FRMH1-CDRH1-FRM2-CDRH2-FRMH3-CDRH3-FRMH4; and
a VKCDR3 amino acid sequence comprising about 1 to about 10 of the amino acids found at Kabat positions 89, 90, 91, 92, 93, 94, 95, 95A, 96, and 97, in selected VKCDR3 amino acid sequences derived from a particular IGKV or IGKJ germline sequence;
wherein the antibody light chain is a variable domain with framework (FRM) and complementary determining regions (CDR) comprising FRMVK1-VKCDR1-FRMVK2-VKCDR2-FRMVK3-VKCDR3-FRMVK4.

US Pat. No. 10,189,872

CRYSTALLINE FORM OF NICOTINAMIDE RIBOSIDE

1. A crystalline Form II of nicotinamide riboside chloride

US Pat. No. 10,189,869

AMINO COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS

Achillion Pharmaceuticals...

1. A method for the treatment of a disorder mediated by complement D selected from paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and C3 glomerulonephritis comprising administering an effective amount to a human in need thereof of a compound of Formula I,or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, wherein:Q1 is C(R1R1?);
Q2 is C(R2R2?);
Q3 is C(R3R3?);
X1 isle;
X2 is CH;
R1, R1?, R2, R2?, R3, and R3? are independently chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C2-C6alkynyl, C2-C6alkanoyl, C1-C6thioalkyl, hydroxyC1-C6alkyl, aminoC1-C6alkyl, —C0-C4alkylR9R10, —C(O)OR9, —OC(O)R9, —NR9C(O)R10, —C(O)NR9R10, —OC(O)NR9R10, —NR9C(O)OR10, C1-C2haloalkyl, and C1-C2haloalkoxy,
or R1 and R2 form a 3- to 6-membered carbocyclic or aryl ring;
or R2 and R3 form a 3- to 6-membered carbocyclic ring;
or R1 and R1?, or R2 and R2?, or R3 and R3? form a 3- to 6-membered carbocyclic Spiro ring;
or R2 and R2? or R3 and R3? form a 3- to 6-membered heterocyclic spiro ring;
each of which ring is unsubstituted or substituted with 1 or more substituents independently, chosen from halogen, hydroxyl, cyano, —COOH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, hydroxyC1-C4alkyl, (mono- and di-C1-C4alkylamino)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), —O—C0-C4alkyl(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
or R1 and R1?, R2 and R2?, or R3 and R3? form a carbonyl group;
or R1 and R2 or R2 and R3 form a carbon-carbon double bond;
R9 and are independently chosen at each occurrence from hydrogen, C1-C6alkyl, (C3-C7cycloalkyl)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), and —O—C0-C4alkyl(C3-C7cycloalkyl);
A is a group selected from:

R5 and R6 are independently selected from CHO, —C(O)NH2, —C(O)NH(CH3), C2-C6alkanoyl, hydrogen, hydroxyl, halogen, cyano, nitro, —COOH, —SO2NH2, vinyl, C1-C6alkyl (including methyl), C2-C6alkenyl, C1-C6alkoxy, —C0-C4alkyl(C3-C7cycloalkyl), —C(O)C0-C4alkyl(C3-C7cycloalkyl), —P(O)(OR9)2, —OC(O)R9, —C(O)OR9, —C(O)N(CH2CH2R9)(R10), —NR9C(O)R10, phenyl, or 5- to 6-membered heteroaryl; and wherein each R5 and R6 other than hydrogen, hydroxyl, cyano, and COOH is unsubstituted or optionally substituted;
R8 and R8? are hydrogen;
X11 is N or CR11;
X12 is N or CR12;
X13 is N or CR13;
X14 is N or CR14, and wherein no more than two of X11, X12, X13, and X14 are N;
one of R12 and R13 is chosen from R31 and the other of R12 and R13 is chosen from R32;
R31 is chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, —COOH, C1-C2haloalkyl, C1-C2haloalkoxy, —C0-C4alkyl(C3-C7cycloalkyl), C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, C2-C6alkenyloxy, —C(O)OR9, C1-C6thioalkyl, —C0-C4alkylNR9R10, —C(O)NR9R10, —SO2R9, —SO2NR9R10, —OC(O)R9, and —C(NR9)NR9R10, each of which R31 other than hydrogen, halogen, hydroxyl, nitro, cyano, C1-C2haloalkyl, and C1-C2haloalkoxy is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, amino, —COON, —CONH2, C1-C2haloalkyl, and C1-C2haloalkoxy, and each of which R31 is also optionally substituted with one substituent chosen from phenyl and 4- to 7-membered heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S; which phenyl or 4- to 7-membered heterocycle is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl)(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
R32 is NR37R38, NR9SO2R38, or N(SO2R9)CH2C(O)R39;
R11, R14, and R15 are independently chosen at each occurrence from hydrogen, halogen, hydroxyl, nitro, cyano, —O(PO)(OR9)2, —(PO)(OR9)2; C2-C6alkenyl, C2-C6alkynyl, C2-C6alkanoyl, C1-C6alkoxy, C1-C6thioalkyl, —C0-C4alkyl(mono- and di-C1-C6alkylamino), —C0-C4alkyl(C3-C7cycloalkyl), —C0-C4alkoxy(C3-C7cycloalkyl), C1-C2haloalkyl and C1-C2haloalkoxy;
R37 is aryl, heteroaryl, heterocycle, (aryl)C0-C4alkyl, (heterocycle)C0-C4alkyl, (heteroaryl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, —S(O)(O)(alkyl), —S(O)(alkyl), —S(O)(O)(heteroalkyl), —S(O)(heteroalkyl), —S(O)(O)(aryl), —S(O)(aryl), —S(O)(O)(heteroaryl), —S(O)(heteroaryl);
R38 is hydrogen, hydroxyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, or —C1-C4alkylC(O)OC1-C6alkyl;
R21 and R22 are independently chosen at each occurrence from hydrogen, hydroxyl, cyano, amino, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy; (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R21 and R22 can be optionally substituted;
R23 is independently chosen at each occurrence from C1-C6alkyl, C1-C6haloalkyl, (aryl)C0-C4alkyl, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R23 can be optionally substituted;
R24 and R25 are taken together with the nitrogen to which they are attached to form a 4- to 7-membered monocyclic heterocycloalkyl group, or a 6- to 10-membered bicyclic heterocyclic group having fused, spiro, or bridged rings, and each R24 and R25 can be optionally substituted;
L is

R17 is hydrogen;
R18 and R18? are independently chosen from hydrogen, halogen, hydroxymethyl, and methyl;
m is 0, 1, 2, or 3;
B is a monocyclic or bicyclic carbocyclic; a monocyclic or bicyclic carbocyclic-oxy group;
a monocyclic, bicyclic, or tricyclic heterocyclic group having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and from 4 to 7 ring atoms per ring; C2-C6alkenyl, C2-C6alkynyl; -(C0-C4alkyl)(aryl); -(C0-C4alkyl)(heteroaryl); or -(C0-C4alkyl)(biphenyl) each of which B is unsubstituted or substituted with one or more substituents independently chosen from R33 and R34, and 0 or 1 substituents chosen from R35 and R36;
R33 is independently chosen from halogen, hydroxyl, —COOH, cyano, C1-C6alkyl, C2-C6alkanoyl, C1-C6alkoxy, —C0-C4alkylNR9—SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy;
R34 is independently chosen from nitro, C2-C6alkenyl, C2-C6alkynyl, C1-C6thioalkyl, —C3-C7cycloalkyl, —B(OH)2, -JC(O)NR9R23, -JOSO2OR21, —C(O)(CH2)1-4S(O)R21, —O(CH2)1-4S(O)NR21R22, -JOP(O)(OR21)(OR22), -JP(O)(OR21)(OR22), -JOP(O)(OR21)R22, -JP(O)(OR21)R22, -JOP(O)R21R22, -JP(O)R21R22, -JSP(O)(OR21)(OR22), SP(O)(OR21)(R22), -JSP(O)(R21)(R22), -JNR9P(O)(NHR21)(NHR22), -JNR9P(O)(OR21)(NHR22), -JNR9P(O)(OR21)(OR22), -JC(S)R21, -JNR21SO2R22, -JNR9S(O)NR10R22, -JNR9SO2NR10R22, -JSO2NR9COR22, JSO2NR9CONR21R22, -JNR21SO2R22, -JC(O)NR21SO2R22, -JC(NH2)NR22, -JC(NH2)NR9S(O)2R22, -JOC(O)NR21R22, -JNR21C(O)OR22, -JNR21OC(O)R22, —(CH2)1-4C(O)NR21R22, -JC(O)R24R25, -JNR9C(O)R21, -JC(O)R21, -JNR9C(O)NR10R22, —CCR21, —(CH2)1-4OC(O)R21, and -JC(O)OR23; each of which R34 may be unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, amino, oxo, —B(OH)2, —Si(CH3)3, —COOH, —CONH2, —P(O)(OH)2, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C1-C6alkoxy, —C0-C2alkyl(mono- and di-C1-C4alkylamino), C1-C6alkylester, C1-C4alkylamino, C1-C4hydroxylalkyl, C1-C2haloalkyl, and C1-C2haloalkoxy;
R35 is independently chosen from naphthyl, naphthyloxy, indanyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl containing 1 or 2 heteroatoms chosen from N, O, and S, and bicyclic heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and containing 4- to 7-ring atoms in each ring, each of which R35 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy; and
R36 is independently chosen from tetrazolyl, (phenyl)C0-C2alkyl, (phenyl)C1-C2alkoxy, phenoxy, and 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently chosen from N, O, B, and S, each of which R36 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, —OSi(CH3)2C(CH3)3, —Si(CH3)2C(CH3)3, C1-C2haloalkyl, and C1-C2haloalkoxy; and
J is independently selected at each occurrence from a covalent bond, C1-C4alkylene, —OC1-C4alkylene, C2-C4alkenylene, and C2-C4alkynylene.

US Pat. No. 10,189,868

METHOD FOR DEPOLYMERISING OXYGENATED POLYMER MATERIALS

1. A process for depolymerizing oxygenated polymer materials by selective cleavage of the oxygen-carbonyl bonds of the ester functions and of the carbonate functions, comprising a step of placing said oxygenated polymer materials in contact with a silane compound of formula (I)
in which
R1, R2 and R3 represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, a silyl group, a siloxy group, an aryl group, an amino group, said alkyl, alkenyl, alkynyl, alkoxy, silyl, siloxy, aryl and amino groups being optionally substituted, or
R1 is as defined above and R2 and R3, taken together with the silicon atom to which they are linked, form an optionally substituted silyl heterocycle;in the presence of a catalyst which is:an organic catalyst selected from the group consisting of
the carbocations of formula (X1)3C+ with X1 representing a hydrogen atom, an alkyl group, an aryl group, an alkoxy group, a silyl group, a siloxy group and a halogen atom;
oxoniums chosen from (CH3)3O+BF4? and (CH3CH2)3O+BF4?;
a silylium ion (R5)3Si+ with R5 representing, independently of each other, a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a heterocycle, a silyl group, a siloxy group;
disilyl cations;
with the anionic counterion of said silylium ion, of said carbocations and of said disilyl cations being
a halide selected from the group consisting of F?, Cl?, Br? and I?; or
an anion selected from the group consisting of BF4?, SbF6?, B(C6F5)4?, B(C6H5)4?, CF3SO3?, PF6?; or
an organometallic catalyst comprising ruthenium or iridium selected from the group consisting of:
the iridium complexes of formula (II):

in which
R6 represents an alkyl or aryl group;
R7 represents a hydrogen atom or an alkyl group;
X2 represents a —CH2? group or an oxygen atom;
Y? represents a counterion selected from the group consisting of B(C6F5)4? and B(C6H5)4; and
S represents a solvent molecule, coordinated to the complex, selected from the group consisting of dimethyl sulfoxide (DMSO), acetonitrile (CH3CN) and acetone (CH3COCH3); and
the ruthenium complexes of formula (III):

in which
R8 represents a hydrogen atom or an alkyl group;
R9 represents an aryl or an alkyl group, said aryl and alkyl groups being optionally substituted;
Z represents a —CH2? group, an oxygen atom or a sulfur atom; and
A?represents a counterion chosen from B(C6F5)4? and [CHB11H5Cl6]?; or
a catalyst of Lewis acid type selected from the group consisting of:
the boron compound selected from the group consisting of BF3, BF3(Et2O), BCl3, BBr3, triphenylhydroborane, tricyclohexylhydroborane, B(C6F5)3, B-methoxy-9borabicyclo[3.3.1]nonane (B-methoxy-9-BBN), B-benzyl-9-borabicyclo[3.3.1]nonane (B-benzyl-9-BBN);
the borenium compound Me-TBD-BBN30, the borenium ferrocene derivatives corresponding to the formula

in which R10=phenyl and R11 =3,5-dimethylpyridyl;
aluminum compounds selected from the group consisting of AlCl3, AlBr3, aluminum isopropoxide (Al(O-i-Pr)3), aluminum ethoxide (Al(C2H3O2)), Krossing's salt [Aq(CH2Cl2)]{Al [OC(CF3)3]4}, the Li{Al[OC(CF3)3]4}, Et2Al+;
indium compounds chosen from InCl3, In(OTf)3;
iron compounds chosen from FeCl3, Fe(OTf)3
tin compounds chosen from SnCl4, Sn(OTf)2,
phosphorus compounds chosen from PCl3, PCl5, POCl3
trifluoromethanesulfonate or triflate compounds (CF3SO3 ?) of transition metals and of lanthanides chosen from scandium triflate, ytterbium triflate, yttrium triflate, cerium triflate, samarium triflate and neodymium triflate.

US Pat. No. 10,189,867

ORGANOSILICON MODIFIED PHOTOINITIATOR AND A PHOTO-CURABLE ADHESIVE COMPOSITION COMPRISING THE SAME

1. An organosilicon modified photoinitiator represented by the general formula (I):wherein,R1 and R2 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl;
one of R3, R4, R5, R6, and R7 is SIL1-X, and the others are each independently selected from the group consisting of hydrogen, C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl C1-C3 alkyl, and halogen;
X is a direct bond or C1-C12 alkylene; and
SIL1 and SIL2 are each independently represented by the formula —SiR8R9R10 or (R?SiO3/2)a(R?2SiO2/2)b(R??3SiO1/2)c, wherein
R8, R9 and R10 are each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, aryl, and aryl C1-C3 alkyl,
R?, R? and R?? each independently selected from the group consisting of C1-C20 alkyl, C2-C8 alkenyl, C5-C8 cycloalkyl, and phenyl C1-C3 alkyl, and
a, b, and c are numbers that satisfy a?0, b?0, c>0, the ratio of a to c is from 0 to 100, and the ratio of b to c is from 0 to 10.

US Pat. No. 10,189,864

METAL COMPLEXES BASED ON A BIS(2-PYRIDYLMETHYL)AMINE-BASED SCAFFOLD AND METHODS OF MAKING THE SAME

Lawrence Livermore Nation...

1. A catalyst, comprising:a ligand comprising a bis(2-pyridylmethyl)amine group, wherein the ligand comprises at least three sp2 nitrogen atoms and at least one sp3 nitrogen atom, and wherein the ligand has a structure selected from the group consisting of:

wherein each R is independently selected from the group consisting of: hydrogen, an ester, an alcohol, and polyethylene glycol (PEG); and
at least one metal cation complexed to the nitrogen atoms of the ligand, wherein the at least one metal cation includes one or more of: Zn2+, and Co2+.

US Pat. No. 10,189,861

PYRIMIDO-DIAZEPINONE COMPOUNDS AND METHODS OF TREATING DISORDERS

DANA-FARBER CANCER INSTIT...

1. A compound having the formula:
or a pharmaceutically acceptable salt thereof,
wherein,
R? is H or methyl;
L is absent, SO2, or CO;
X is H, methyl, fluoro, chloro, phenyl, pyridinyl, thiophenyl, —NH—CO—CH?CH—CH2—N(CH3)2, —S(O)2—N(CH3)2, or

Z is NH or N—C1-C3 alkyl;
R2 is hydrogen or methyl;
R6 is hydrogen; and
R1 is H, C?O(CH3),

US Pat. No. 10,189,860

HYDRATES OF DOLUTEGRAVIR SODIUM

1. A crystalline form of dolutegravir sodium of formula (I)characterized by a powder X-ray diffractogram comprising peaks at 2-Theta angles of 7.9±0.2°, 9.4±0.2°, 12.5±0.2°, 15.9±0.2° and 20.8±0.2°, when measured with Cu-Katz radiation having a wavelength of 0.15419 nm at room temperature wherein the crystalline form comprises 0.2 to 0.7 mol of water per mol dolutegravir sodium of formula (I) when measured at a relative humidity from 30 to 70% and a temperature of 25±0.1° C.

US Pat. No. 10,189,858

DEUTERIUM-ENRICHED ISOINDOLINONYL-PIPERIDINONYL CONJUGATES AND OXOQUINAZOLIN-3(4H)-YL-PIPERIDINONYL CONJUGATES AND METHODS OF TREATING MEDICAL DISORDERS USING SAME

DeuteRx, LLC, Andover, M...

1. A deuterium-enriched compound, wherein the compound is selected from the group consisting of:(i) a compound of Formula II represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%,
(ii) a compound of Formula III represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%,
(iii) a compound of Formula IV represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%, and
(iv) a compound of Formula IV represented by:

or a pharmaceutically acceptable salt thereof; wherein Z is H or D, provided that the abundance of deuterium in Z is at least 30%.

US Pat. No. 10,189,857

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4

Vanderbilt University, N...

1. A compound of formula (I),
or a pharmaceutically acceptable salt thereof, wherein:
W is selected from CR1 and N;
X is selected from CR1 and N;
Y is selected from CR1 and N;
each R1 is independently selected from hydrogen and C1-C6 alkyl;
R2 is hydrogen or C1-C6 alkyl;
R3a and R3b are each independently selected from hydrogen and C1-C6 alkyl, or R3a and R3b are taken together with the nitrogen atom to which they are attached to form an optionally substituted ring;
R4a is hydrogen and R4b is selected from alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heteroalkyl, heterocyclyl, and —(CRaRb)n—Z, any of which may be optionally substituted; or R4a and R4b, together with the nitrogen atom to which they are attached, are taken together to form an optionally substituted heterocyclic ring;
Ra is hydrogen;
Rb is hydrogen;
Z is selected from halo, —OR, —SR, —C(O)R, —C(O)OR, —S(O)R, —SO2R, —NR2, —C(O)NR2, —S(O)2NR2, aryl, heteroaryl, cycloalkyl, and heterocyclyl, any of which may be optionally substituted;
n is 1, 2, 3, 4, 5, 6, 7, or 8; and
each R is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, heteroaryl, heteroarylalkyl, and heteroalkyl, any of which may be optionally substituted.

US Pat. No. 10,189,854

SUBSTITUTED PYRIMIDINE COMPOUNDS

GRUENENTHAL GMBH, Aachen...

1. A method of treating a condition or disease which can be treated by inhibition of PDE4 enzyme in a subject, comprising administering to the subject a compound of formula (I)
wherein
A, B and C independently represent CH or N;
R1 and R2 independently represent
hydrogen or (C1-C6)-alkyl, whereby said (C1-C6)-alkyl is unsubstituted or substituted with at least one substituent X1, or
a group U, which is a 3- to 12-membered mono- or bi-cycloaliphatic ring, which is unsubstituted or substituted with at least one substituent X2, whereby said group U may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn is unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
a group V, which is a 3- to 12-membered mono- or bi-cyclic heterocycloaliphatic ring comprising at least one heteroatom selected from the group consisting of O, S and N as a ring member, and which mono- or bicyclic heterocycloaliphatic ring is unsubstituted or substituted with at least one substituent X3, whereby said group V may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn may be unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
a group W which is phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl is unsubstituted or substituted with at least one substituent X4 and may be condensed with a 4-, 5-, 6- or 7-membered ring, being carbocyclic or heterocyclic, wherein said condensed ring may be saturated, partially unsaturated or aromatic and may be substituted with at least on substituent X5, and whereby group W may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn may be unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
R1 and R2 together with the nitrogen atom to which they are attached form a 3- to 12-membered monocyclic or bicyclic non-aromatic or aromatic ring wherein said ring may contain at least one additional heteroatom selected from the group consisting of O, S and N and wherein said ring is unsubstituted or substituted with at least one substituent X6;
R3 and R4,
independently represent hydrogen, (C1-C6)-alkyl or (C3-C6)-cycloalkyl, wherein said (C1-C6)-alkyl and (C3-C6)-cycloalkyl are each unsubstituted or substituted with at least one substituent Y1, or
together with the carbon atom to which they are attached form a 3- to 6-membered cycloalkyl ring, which is unsubstituted or substituted with at least one substituent Y2;
L represents a bond, O, S, (C1-C6)-alkylene or (C2-C6)-alkenylene, whereby the aforementioned alkylenes or alkenylenes are in each case unsubstituted or substituted with at least one substituent selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH;
G represents a phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl may be substituted with at least one substituent Z;
X1, X2, X3, X5 and X6, at each occurrence are independently from one another selected from the group consisting of OH, ?O, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO—(C1-C6)-alkyl, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
X4 at each occurrence are independently from one another selected from the group consisting of OH, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
Y1 and Y2, at each occurrence are independently from one another selected from the group consisting of OH, ?O, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
Z at each occurrence is independently selected from the group consisting of halogen, OH, CN, SH, nitro, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C1-C6)-hydroxyalkyl, (C1-C6)-cyanoalkyl, (C1-C6)-alkoxy, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl, (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-alkylen-S—(C1-C6)-alkyl, (C3-C8)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C3)-alkylenyl, (C3-C8)-heterocycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—CO—O—(C1-C6)-alkyl, NH—C(O)NH2, NH—CO—NH—(C1-C6)-alkyl, NH—CO—N((C1-C6)-alkyl)2, NH((C1-C6)-alkylen)-CO—O—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CONH2, NH((C1-C6)-alkylen)-CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, NH—S(O)2OH, NH—S(O)2(C1-C6)-alkyl, NH—S(O)2O(C1-C6)-alkyl, NH—S(O)2NH2, NH—S(O)2NH(C1-C6)-alkyl, NH—S(O)2N((C1-C6)-alkyl)2, NH((C1-C6)-alkylen)-S(O)2OH, NH((C1-C6)-alkylen)-S(O)2(C1-C6)-alkyl, NH((C1-C6)-alkylen)-S(O)2O(C1-C6)-alkyl, NH((C1-C6)-alkylen)-S(O)2NH2, NH((C1-C6)-alkylen)-S(O)2NH(C1-C6)-alkyl, CO2H, CO(C1-C6)-alkyl, CO—O(C1-C6)-alkyl, O—CO(C1-C6)-alkyl, O—CO—O(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)-alkyl, CO—N((C1-C6)-alkyl)2, O—CO—NH(C1-C6)-alkyl, O—CO—N((C1-C6)-alkyl)2, O—S(O)2—(C1-C6)-alkyl, O—S(O)2OH, O—S(O)2—(C1-C6)-alkoxy, O—S(O)2NH2, O—S(O)2—NH(C1-C6)-alkyl, O—S(O)2—N((C1-C6)-alkyl)2, S(O)(C1-C6)-alkyl, S(O)2(C1-C6)-alkyl, S(O)2OH, S(O)2O(C1-C6)-alkyl, S(O)2NH2, S(O)2NH(C1-C6)-alkyl, and S(O)2N((C1-C6)-alkyl)2;
wherein the compound of formula (I) is in its presented form or its acid or base form, or in the form of a physiologically acceptable salt, or in its solvate form, or in the form of its racemates, its pure stereoisomers, enantiomers or diastereomers, or in the form of mixtures of stereoisomers, enantiomers or diastereomers, in any mixing ratio,
wherein the condition or disease is
psoriatic arthritis; or
psoriasis; or
chronic obstructive pulmonary disease (COPD).

US Pat. No. 10,189,851

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A compound of the structure:

US Pat. No. 10,189,849

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A compound of the structure:

US Pat. No. 10,189,848

ETHYNYL DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula IwhereinR1 is lower alkyl;
R2 is phenyl or pyridinyl, wherein the N atom in the pyridinyl group may be in different positions;
n is 0, 1 or 2;
V/U are independently from each other O or CH2, wherein V and U cannot be simultaneously O;
L is a five or six membered heteroaryl group, selected from
or a pharmaceutically acceptable salt or acid addition salt, a racemic mixture, or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.

US Pat. No. 10,189,847

OXIME ESTER COMPOUND AND PHOTOPOLYMERIZATION INITIATOR CONTAINING SAID COMPOUND

ADEKA CORPORATION, Tokyo...

1. An oxime ester compound represented by general formula (I):wherein R1 and R2 each independently represent R11, OR11, COR11, SR11, CONR12R13, or CN;R11, R12, and R13 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, and R13 being optionally further substituted by R21, OR21 COR21, SR21, NR22R23, CONR22R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
R21, R22, and R23 each independently represent a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R21, R22, and R23 being optionally further substituted by a hydroxyl group, a nitro group, CN, a halogen atom, a hydroxyl group, or a carboxyl group,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, R13, R21, R22and R23 having an alkylene moiety optionally interrupted by —O—, —S—, —COO—, —OCO—, —NR24—, —NR24CO—, —NR24COO—, —OCONR24—, —SCO—, —COS—, —OCS—, or —CSO— at 1 to 5 sites provided that no two oxygen atoms are directly bonded to each other;
R24 represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R11, R12, R13, R21, R22, R23, and R24 having an alkyl moiety that is optionally branched or cyclic;
R3 represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R3 having an alkyl moiety that is optionally branched or cyclic,
R3 and R7, R3 and R8, R4 and R5, R5 and R6, and R6 and R7 being optionally taken together to form a ring,
the alkyl group, the aryl group, the arylalkyl group or the heterocyclic group represented by R3 being optionally further substituted by R21, OR21, COR21, SR21, NR22R23, CONR23R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
R4, R5, R6, and R7 each independently represent R11, OR11, SR11, COR14, CONR15R16, NR12COR11, OCOR11, COOR14, SCOR11, OCSR11, COSR14, CSOR11, a hydroxyl group, CN, or a halogen atom,
R4 and R5, R5 and R6, and R6 and R7 being optionally taken together to form a ring;
R14, R15, and R16 each represent a hydrogen atom or an alkyl group having 1 to 20 carbon atoms,
the alkyl group represented by R14, R15, and R16 being optionally branched or cyclic;
R8 represents R11, OR11, SR11, COR11, CONR12R13, NR 12COR11, OCOR11, COOR11, SCOR11, OCSR11, COSR11, CSOR11, a hydroxyl group, CN, or a halogen atom; and
n represents 0 or 1, and
the oxime ester compound represented by general formula (I) satisfies any of following (1) to (4):
(1) n is 1,
(2) at least one of R4, R5, R6, and R7 is R11, OR11, SR11, COR14, CONR15R16, NR12COR11, OCOR11, SCOR11, OCSR11, COSR14, CSOR11, a hydroxyl group, CN, or a halogen atom; and satisfies the following conditions (2-1) and (2-2);
(2-1) when any of R4, R5, R6, and R7 is R11, R11 represents an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms, and the hydrogen atom of the group represented by R11 is further substituted by OR21, COR21, SR21, NR22R23, CONR22R23, —NR22—OR23, —NCOR22—OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
(2-2) when any of R4, R5, R6, and R7 is OR11, OR11, OR11represents an alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 30 carbon atoms, an arylalkyl group having 7 to 30 carbon atoms, or a heterocyclic group having 2 to 20 carbon atoms, and the hydrogen atom of the group represented by R11 is further substituted by OR21, COR21, SR21, NR22R23, CONR22R23, —NR22 —OR23, —NCOR22 —OCOR23, NR22COR21, OCOR21, COOR21, SCOR21, OCSR21, COSR21, CSOR21, a hydroxyl group, a nitro group, CN, a halogen atom, or COOR21;
(3) R3 is an arylalkyl group having 7 to 30 carbon atoms or a heterocyclic group having 2 to 20 carbon atoms,
(4) R3 and R7, R3 and R8, R4 and R5, R5 and R6, or R6 and R7 are taken together to form a ring.

US Pat. No. 10,189,846

HEPATITIS B ANTIVIRAL AGENTS

ENANTA PHARMACEUTICALS, I...

1. A compound represented by Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
A is optionally substituted monocyclic heteroaryl;
B is hydrogen or methyl;
X is optionally substituted phenyl;
Y is optionally substituted phenyl or optionally substituted monocyclic heteroaryl; and
R and Z are taken together with the atoms to which they are attached to form an optionally substituted 4- to 12-membered heterocyclic.

US Pat. No. 10,189,842

WNT PATHWAY MODULATORS

Agency for Science, Techn...

10. A pharmaceutical composition comprising a compound according to claim 1 in combination with one or more therapeutically acceptable adjuvents, diluents or carriers.

US Pat. No. 10,189,835

DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

NOVIRA THERAPEUTICS, INC....

1. A compound of Formula IV:
or a pharmaceutically acceptable salt thereofwhereinY is selected from a bond, —C(O)—, and —SO2—;
R1 is selected from C(O)ORc, C(O)Rc, C(O)NRdRe, and —C(O)NRdN(Rd)2;
R2 is, at each occurrence, independently selected from H, —OH, halo, and C1-C6-alkyl;
R3 is, at each occurrence, independently selected from H, —OH, halo, and C1-C6-alkyl;
R4 is selected from (CR8R9)p—C6-C12-aryl and (CR8R9)p—C1-C9-heteroaryl, wherein aryl and heteroaryl are optionally substituted with 1, 2,or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R5 is, at each occurrence, independently selected from H, —OH, and halo;
R6 is, at each occurrence, independently selected from H, —OH, and halo;
alternatively,

R8 is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R9 is, at each occurrence, independently selected from H and C1C6-alkyl;
Rc is selected from H, C1-C6-alkyl,C1-C6-alkyl-OH, C0-C6-alkyl-C3-C8-cycloalkyl, C2-C8-heterocyclyl, C6-C12-aryl, and C1-C9-heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, and —O—C1-C6-alkyl;
Rd is selected from H, C1-C6-alkyl, and C1-C6-alkyl-OH;
Re is selected from H, C1-C6-alkyl, C1-C6-alkyl-OH, C1-C6-alkyl-OC1-C6-alkyl, C0-C6-alkyl-C3-C8-cycloalkyl, C2-C8-heterocyclyl, C6-C12-aryl, and C1-C9-heteroaryl, wherein cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH, halo, CN, C1-C6-alkyl, C1-C6-haloalkyl, and —O—C1-C6-alkyl;
m is 0, 1, or 2; and
p is 0, 1, 2, 3, or 4.

US Pat. No. 10,189,832

CRYSTALLINE SOLID FORMS OF A BET INHIBITOR

Incyte Corporation, Wilm...

1. A solid form of a compound having the formula:
wherein the solid form is crystalline;
and wherein the solid form has Form I and has a characteristic XRPD peak, in terms of 2-theta, at about 12.7 degrees.

US Pat. No. 10,189,830

ALKYL-HETEROARYL SUBSTITUTED QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS

BIOELECTRON TECHNOLOGY CO...

1. A compound of Formula I or Formula II:
wherein:
R1, R3 and R4 are independently C1-C6 alkyl or O—C1-C6 alkyl;
R2 is heteroaryl selected from the group consisting of benzoimidazole, benzothiazole, and benzoxazole, optionally substituted with one or two substituents independently selected from the group consisting of halo, —CH3, —CF3, —OCH3, and —C(O)—N(R5)(R6), wherein the substituents are independently linked to the heteroaryl by either a —C— or —N—within the heteroaryl; where the attachment point of the heteroaryl group to the rest of the molecule is either through a C or N in the rings;
R5 and R6 are independently selected from the group consisting of —H, —C1-C6 alkyl, and —C1-C6 alkyl-hydroxy, or wherein R5 and R6 together with the N to which they are attached form a saturated or unsaturated 3-8 membered ring, optionally incorporating one, two, or three additional heteroatoms each independently selected from the group consisting of N, O, and S, and wherein the ring is optionally substituted with —C1-C6 alkyl; and
z is 3;
or a stereoisomer, mixture of stereoisomers, solvate, hydrate, pharmaceutically acceptable salt or prodrug ester thereof.

US Pat. No. 10,189,826

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Medivation Technologies L...

1. A compound of Formula (IIa):
or a pharmaceutically acceptable salt thereof, wherein:
RC5 is halogen;
each RC7 and RC8 is independently hydrogen, R1, or —SO2RC12; or RC7 and RC8 are taken together with the N to which they are attached to form a C3-C8 heterocycle optionally substituted with one or more R1 or R3;
R1 is C1-C6 linear or branched alkyl, C2-C6 linear or branched alkenyl, C2-C6 linear or branched alkynyl, C3-C6 cycloalkyl, C3-C6 cycloalkylmethyl, C3-C6 cycloalkenyl, aryl, or heteroaryl; each optionally substituted with one or more R3;
R3 is halogen, —CN, —OH, —O(Alkyl), ?O, —NO2, —SH, —S(Alkyl), —S(O)(Alkyl), —S(O)2(Alkyl), —CH2OCH3, —OBn, —CO2H, —CO2(Alkyl), —NR10R11, —CONR10R11, or —S(O)2NR10R11;
R10 and R11 are independently hydrogen, C1-C6 linear or branched alkyl, —C(O)RC12, —C(O)2RC12, —C(O)N(RC12)2, —SO2RC12, or are taken together with the N to which they are attached to form a C3-C8 heterocyclyl; and
RC12 is hydrogen, a linear or branched C1-C6 alkyl, a linear or branched C2-C6 alkenyl, a linear or branched C2-C6 alkynyl, or aryl; wherein each alkyl, alkenyl, alkynyl, or aryl group is optionally substituted with one or more halogen atoms, one or more —NH2 groups, or one or more —OH groups.

US Pat. No. 10,189,824

PYRIMIDINE-DIAMINE DUAL HSP90/TRAP1 INHIBITORS

Calasia Pharmaceuticals, ...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R1 is hydrogen, halo, (C1-C3)alkyl, halo(C1-C3)alkyl, (C1-C3)alkoxy, or halo(C1-C3)alkoxy;
R3, R4, and R5 are independently hydrogen, halo, (C1-C3)alkyl, halo (C1-C3)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, cyano,
R2 is heteroaryl or heterocycyl, each of which are optionally substituted with 1 to 2 groups independently selected from R6, but not 4-morpholinyl or benzo[d][1,3]dioxol-5-yl;p is 0, 1, or 2;
R6 is selected from halo, cyano, nitro, amino, hydroxy, carboxy, (C1-C6)alkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroalkyl, heterocyclylalkyl, hydroxy(C1-C6)alkyl, CO2H, (CH2)1-3COOH, (C1-C3)alkylcarbonyloxy, (C3-C6)cycloalkyl, hydroxy(C3-C6)cycloalkyl, (C4-C7)cycloalkylalkyl, (C2-C6)alkenyl, halo(C2-C6)alkenyl, hydroxy(C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl(C2-C4)alkynyl, halo(C1-C6)alkyl, halo(C3-C6)cycloalkyl, halo(C4-C7)cycloalkylalkyl, (C1-C6)alkoxy, (C3-C6)cycloalkoxy, (C4-C7)cycloalkylalkoxy, halo(C1-C6)alkoxy, halo(C3-C6)cycloalkoxy, halo(C4-C7)cycloalkylalkoxy, (C1-C6)alkylthio, (C3-C6)cycloalkythio, (C4-C7)cycloalkylalkylthio, halo(C1-C6)alkylthio, halo(C3-C6)cycloalkythio, halo(C4-C7)cycloalkylalkylthio, (C1-C6)alkylsulfinyl, (C3-C6)cycloalkylsulfinyl, (C4-C7)cycloalkylalkylsulfinyl, halo(C1-C6)alkylsulfonyl, halo(C3-C6)cycloalkylsulfinyl, halo(C4-C7)cycloalkylalkylsulfinyl, (C1-C6)alkylsulfonyl, (C3-C6)cycloalkylsulfonyl, (C4-C7)cycloalkylalkylsulfonyl, halo(C3-C6)cycloalkylsulfonyl, halo(C4-C7)cycloalkylalkylsulfonyl, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkoxy(C1-C6)alkoxy, halo(C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, H2NCO, H2NSO2, (C1-C6)alkylaminocarbonyl, di(C1-C6)alkylaminocarbonyl, (C1-C3)alkoxy(C1-C3)alkylaminocarbonyl, heterocyclylcarbonyl, (C1-C6)alkylaminosulfonyl, di(C1-C6)alkylaminosulfonyl, heterocyclylsulfonyl, (C1-C6)alkylcarbonylamino, (C1-C6)alkyl-carbonylamino(C1-C6)alkyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkoxy(C1-C6)alkyl, hydroxy(C1-C6)alkoxy, oxo, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl amino(C2-C6)alkoxy, (C1-C6)alkylamino(C2-C6)alkoxy, di(C1-C6)alkylamino(C2-C6)alkoxy, (C1-C6)alkylcarbonyl, hydroxy(C1-C6)alkylcarbonyl, (C1-C6)alkylhydroxycarbonyl, (C1-C6)alkylhydroxy(C1-C6)alkyl, (C3-C6)cycloalkylcarbonyl, (C3-C6)cycloalkylaminocarbonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl, di(C3-C6)cycloalkylaminocarbonyl, (C3-C6)cycloalkylaminosulfonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminosulfonyl, di(C3-C6)cycloalkylaminosulfonyl, cyano(C1-C6)alkyl, aminocarbonyl(C1-C6)alkyl, (C1-C6)alkylaminocarbonyl(C1-C6)alkyl, di(C1-C6)alkylaminocarbonyl(C1-C6)alkyl, (C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl(C1-C6)alkyl, [(C1-C6)alkyl(C4-C6)heterocyclyl](C1-C6)alkyl, and di(C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl;
R7 and R8 are independently hydrogen or alkyl; and
R9 is H or alkyl.

US Pat. No. 10,189,823

NEPRILYSIN INHIBITORS

1. A method for treating hypertension, the method comprising administering to patient a therapeutically effective amount of a compound of the following structure:or a pharmaceutically acceptable salt thereof;wherein the hypertension is selected from the group consisting of primary hypertension, secondary hypertension, hypertension with accompanying renal disease, severe hypertension with or without accompanying renal disease, pulmonary hypertension, and resistant hypertension.

US Pat. No. 10,189,822

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

3-V Biosciences, Inc., M...

1. A method of treating a cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of:
wherein the cancer is selected from mantle cell lymphoma; chronic myelogenous leukemia; sarcoma; endometrial tumors; non-small cell lung carcinoma; gastric carcinomas; hepatocellular tumors; and head and neck cancer.

US Pat. No. 10,189,820

HETEROCYCLIC AMIDES USEFUL AS PROTEIN MODULATORS

GlaxoSmithKline Intellect...

1. A compound which is (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide having the structure ofor a tautomer thereof,or a pharmaceutically acceptable salt thereof,or a hydrate thereof.

US Pat. No. 10,189,819

FACTOR IXA INHIBITORS

Mochida Paraceuticals Co....

1. A compound of Formula I:
wherein A is selected from:

R1 is phenyl, which is optionally substituted with halo, R5, (C?O)OR5, (C?O)NR5R6 or C1-3 alkyl(C?O)OR5; or heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, R5, OR5, NR5R6 and C1-3 alkyl-NR5R6;
R2 is hydrogen or C1-6 alkyl;
R3 is heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, cyclopropyl, R5, OR5, (C?O)OR5 and CH2SO2CH3;
each R4 is independently selected from halo, R5 or OR5,
each R5 is hydrogen or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
R6 is hydrogen, cyclopropyl or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
Ra is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rb is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rc is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rd is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Re is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rf is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rg is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rh is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
n is an integer between zero and two;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,817

INHIBITORS OF BRUTON'S TYROSINE KINASE

BIOGEN MA INC., Cambridg...

1. A compound of formula A:wherein —ORLG is a suitable leaving group.

US Pat. No. 10,189,812

BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION

THE KEY LABORATORY OF CHE...

1. A compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and pharmaceutically acceptable salt thereof,
wherein,
X1 is selected from hydrogen, halogen, nitro, nitroso, —SO3H or optionally substituted sulfonyl;
X2 is independently selected from hydrogen, halogen, nitro, nitroso, —SO3H, optionally substituted amino or optionally substituted sulfonyl;
X3 and X4 are hydrogen;
said optionally substituted sulfonyl is selected from —SO3H, sulfonyl substituted with arylamino, sulfonyl substituted with alkyl sulfonyl substituted with alkyl substituted with alkoxy or sulfonyl substituted with halogen;
said optionally substituted amino is selected from amino substituted with alkylcarbonyl, amino substituted with hydroxy substituted alkylcarbonyl, amino substituted with alkylcarbonyl, amino substituted with alkenylcarbonyl, amino substituted with alkynylcarbonyl, amino substituted with alkoxycarbonyl, amino substituted with aryl substituted alkoxycarbonyl, amino substituted with cycloalkylcarbonyl, amino substituted with arylcarbonyl, amino substituted with halogen substituted arylcarbonyl, amino substituted with alkoxy substituted arylcarbonyl, amino substituted with haloalkyl substituted arylcarbonyl, amino substituted with furylcarbonyl, amino substituted with thienylcarbonyl, amino substituted with morpholinylcarbonyl, amino substituted with aminocarbonyl, amino substituted with alkoxycarbonylcarbonyl, amino substituted with alkylsulfonyl, amino substituted with alkenylsulfonyl, amino substituted with alkynylsulfonyl, amino substituted with alkoxysulfonyl, amino substituted with arylsulfonyl, amino substituted with nitro substituted arylsulfonyl, amino substituted with alkyl substituted arylsulfonyl, amino substituted with halogen substituted arylsulfonyl, amino substituted with aminosulfonyl or arylalkylsulfonyl substituted amino;
R1 is independently selected from hydrogen, nitroso, alkyl, alkyl substituted with aryl, alkenyl, alkynyl, aryl, arylcarbonyl, alkylcarbonyl, alkenylcarbonyl or alkynylcarbonyl;
R2 is hydrogen;
x is 1, 2 or 3;
y is 1, 2, 3 or 4; and
z is 1 or 2;
provided that:
X1, X2, X3 and X4 are not hydrogen simultaneously; and
when one of X1 and X2 is halogen, the rest of X1 and X2 are independently selected from hydrogen, nitro, nitroso, —SO3H, optionally substituted amino or optionally substituted sulfonyl, but they are not hydrogen simultaneously and X1 is not optionally substituted amino.

US Pat. No. 10,189,810

PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS

VERSEON CORPORATION, Fre...

1. A compound comprising a substituted or unsubstituted pyridone ring attached to a substituted or unsubstituted pyrazole ring with structure of Formula (I):
or pharmaceutically acceptable salt thereof;
wherein
L1 is NR6—;
L2 is C(?O)—;
L4 is a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, —S—, —SO—, or —SO2—;
L3 and L5 are independently a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, or —O—;
R1 is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted fused ring aryl, or substituted or unsubstituted heteroaryl;
R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted fused ring aryl, or substituted or unsubstituted heteroaryl;
R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted fused ring aryl, or substituted or unsubstituted heteroaryl;
R3 and R5 are independently hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and
R6 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
provided that if the compound has a structure according to Formula (IIa), as follows, either L3 is not a bond or R3 is not hydrogen:

US Pat. No. 10,189,809

SGC STIMULATORS

Ironwood Pharmaceuticals,...

1. A compound according to Formula I, or a pharmaceutically acceptable salt thereof,
wherein:
ring B is a phenyl or a 6-membered heteroaryl ring containing 1 or 2 nitrogen atoms in the ring;
n is an integer selected from 0 to 3;
each JB is independently selected from halogen, —CN, —NO2, a C1-6 aliphatic, —ORB or a C3-8 cycloaliphatic group; wherein each said C1-6 aliphatic and each said C3-8 cycloaliphatic group is optionally and independently substituted with up to 3 instances of R3;
each RB is independently selected from hydrogen, a C1-6 aliphatic or a C3-8 cycloaliphatic; wherein each said C1-6 aliphatic and each said C3-8 cycloaliphatic ring is optionally and independently substituted with up to 3 instances of R3;
each R3 is independently selected from halogen, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C 1-4 alkyl) or —O(C1-4 haloalkyl);
X is C-JD or C—H;
o is an integer selected from 0 to 3;
each JD is independently selected from —NO2, —ORD, —SRD, —C(O)RD, —C(O)ORD, —C(O)N(RD)2, —CN, —N(RD)2, —N(Rd)C(O)RD, —N(Rd)C(O)ORD, —SO2RD, —SO2N(RD)2, —N(Rd)SO2RD, a C1-6 aliphatic, —(C1-6 aliphatic)-RD, a C3-8 cycloaliphatic ring, a 6 to 10-membered aryl ring, a 4 to 8-membered heterocyclic ring or a 5 to 10-membered heteroaryl ring; wherein each said 4 to 8-membered heterocylic ring and each said 5 to 10-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic, each said C3-8 cycloaliphatic ring, each said 6 to 10-membered aryl ring, each said 4 to 8-membered heterocyclic ring and each said 5 to 10-membered heteroaryl ring is optionally and independently substituted with up to 3 instances of R5;
each RD is independently selected from hydrogen, a C1-6 aliphatic, —(C1-6 aliphatic)-Rf, a C3-8 cycloaliphatic ring, a 4 to 8-membered heterocyclic ring, phenyl or a 5 to 6-membered heteroaryl ring; wherein each said 4 to 8-membered heterocylic ring and each said 5 to 6-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic, each said C3-8 cycloaliphatic ring, each said 4 to 8-membered heterocyclic ring, each said phenyl and each said 5 to 6-membered heteroaryl ring is optionally and independently substituted with up to 3 instances of R5;
each Rd is independently selected from hydrogen, a C1-6 aliphatic, —(C1-6 aliphatic)-Rf, a C3-8 cycloaliphatic ring, a 4 to 8-membered heterocyclic ring, phenyl or a 5 to 6-membered heteroaryl ring; wherein each said heterocylic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic, each said C3-8 cycloaliphatic ring, each said 4 to 8-membered heterocyclic ring, each said phenyl and each said 5 to 6-membered heteroaryl ring is optionally and independently substituted by up to 3 instances of R5;
each Rf is independently selected from a C3-8 cycloaliphatic ring, a 4 to 8-membered heterocyclic ring, phenyl or a 5 to 6-membered heteroaryl ring; wherein each said heterocylic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C3-8 cycloaliphatic ring, each said 4 to 8-membered heterocyclic ring, each said phenyl and each said 5 to 6-membered heteroaryl ring is optionally and independently substituted by up to 3 instances of R5;
alternatively, two instances of RD linked to the same nitrogen atom of JD, together with said nitrogen atom of JD, form a 4 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring is optionally and independently substituted by up to 3 instances of R5; or
alternatively, one instance of RD linked to a carbon, oxygen or sulfur atom of JD and one instance of Rd linked to a nitrogen atom of the same JD, together with said carbon, oxygen or sulfur and said nitrogen atom of that same JD, form a 4 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring is optionally and independently substituted by up to 3 instances of R5;
each R5 is independently selected from halogen, —CN, —NO2, C1-4 alkyl, a C7-12 aralkyl, C3-8 cycloalkyl ring, C1-4 haloalkyl, C1-4 cyanoalkyl, —OR6, —SR6, —COR6, —OC(O)R6, —C(O)OR6, —C(O)N(R6)2, —N(R6)C(O)R6, —N(R6)2, —SO2R6, —SO2N(R6)2, —N(R6)SO2R6, phenyl or an oxo group; wherein each said phenyl group is optionally and independently substituted with up to 3 instances of halogen, —OH, —NH2, —NH(C 1-4 alkyl), —N(C1-4 alkyl)2, —NO2, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C1-4 alkyl) or —O(C1-4 haloalkyl); and wherein each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 instances of halogen;
each R6 is independently selected from hydrogen, a C1-4 alkyl, a C2-4 alkenyl, phenyl, a C7-12 aralkyl or a C3-8 cycloalkyl ring; wherein each of said C1-4 alkyl, each said C2-4 alkenyl, each said phenyl, each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 instances of halogen;
alternatively, two instances of R6 linked to the same nitrogen atom of R5, together with said nitrogen atom of R5, form a 5 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; or
alternatively, one instance of R6 linked to a nitrogen atom of R5 and one instance of R6 linked to a carbon or sulfur atom of the same R5, together with said nitrogen and said carbon or sulfur atom of the same R5, form a 5 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S;
or, alternatively, two JD groups attached to two vicinal ring D atoms, taken together with said two vicinal ring D atoms, form a 5 to 7-membered heterocycle resulting in a fused ring D wherein said 5 to 7-membered heterocycle contains from 1 to 3 heteroatoms independently selected from N, O or S; and wherein said 5 to 7-membered heterocycle is optionally and independently substituted by up to 3 instances of halogen, —OH, —NH2, —NH(C 1-4 alkyl), —N(C1-4 alkyl)2, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C1-4 alkyl), —O(C1-4 haloalkyl) oxo or phenyl; wherein said phenyl is optionally and independently substituted by up to three instances of halogen, —OH, —NH2, —NH(C1-4 alkyl), —N(C1-4 alkyl)2, —NO2, —CN, C1-4 alkyl, C1-4 haloalkyl, —O(C1-4 alkyl) or —O(C1-4 haloalkyl);
RC is selected from —CN or a ring C;
ring C is a phenyl ring, a monocyclic 5 or 6-membered heteroaryl ring, a bicyclic 8 to 10-membered heteroaryl ring, a monocyclic 3 to 10-membered cycloaliphatic ring, or a monocyclic 4 to 10-membered heterocycle ; wherein said monocyclic 5 or 6-membered heteroaryl ring, said bicyclic 8 to 10-membered heteroaryl ring, or said monocyclic 4 to 10-membered heterocycle contain between 1 and 4 heteroatoms selected from N, O or S; wherein said monocyclic 5 or 6-membered heteroaryl ring is not a 1,3,5-triazinyl ring; and wherein said phenyl, monocyclic 5 to 6-membered heteroaryl ring, bicyclic 8 to 10-membered heteroaryl ring, or monocyclic 4 to 10-membered heterocycle is optionally and independently substituted with up to 3 instances of JC;
each JC is independently selected from halogen, —CN, —NO2, a C1-6 aliphatic, —ORH, —SRH, —N(RH)2, a C3-8 cycloaliphatic ring or a 4 to 8-membered heterocyclic ring; wherein said 4 to 8-membered heterocyclic ring contains 1 or 2 heteroatoms independently selected from N, O or S; wherein each said C1-6 aliphatic, each said C3-8 cycloaliphatic ring and each said 4 to 8-membered heterocyclic ring, is optionally and independently substituted with up to 3 instances of R7; or alternatively, two JC groups attached to two vicinal ring C atoms, taken together with said two vicinal ring C atoms, form a 5 to 7-membered heterocycle resulting in a fused ring C; wherein said 5 to 7-membered heterocycle contains from 1 to 2 heteroatoms independently selected from N, O or S;
each RH is independently selected from hydrogen, a C1-6 aliphatic, a C3-8 cycloaliphatic ring or a 4 to 8-membered heterocyclic ring, wherein each said 4 to 8-membered heterocylic ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic, each said C3-8 cycloaliphatic ring, each said 4 to 8-membered heterocyclic ring, is optionally and independently substituted with up to 3 instances of R7;
alternatively, two instances of RH linked to the same nitrogen atom of JC, together with said nitrogen atom of JC, form a 4 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring is optionally and independently substituted by up to 3 instances of R7; or
each R7 is independently selected from halogen, —CN, —NO2, C1-4 alkyl, C1-4 haloalkyl, C3-8 cycloalkyl ring, —OR8, —SR8, —N(R8)2, or an oxo group; wherein each said cycloalkyl group is optionally and independently substituted with up to 3 instances of halogen;
each R8 is independently selected from hydrogen, a C1-4 alkyl, C1-4 haloalkyl or a C3-8 cycloalkyl ring; wherein each said cycloalkyl group is optionally and independently substituted with up to 3 instances of halogen;
alternatively, two instances of R8 linked to the same nitrogen atom of R7, together with said nitrogen atom of R7, form a 5 to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S;
RA is selected from hydrogen, halogen, C1-4 alkyl or C1-4 haloalkyl.

US Pat. No. 10,189,807

TETRAHYDROTHIOPHENE-BASED GABA AMINOTRANSFERASE INACTIVATORS

Northwestern University, ...

1. A method of modulating activity of a GABA aminotransferase, said method comprising: providing a compound of a formula
or a salt thereof; and
contacting said compound with a medium comprising GABA aminotransferase, said compound in an amount effective to modulate GABA aminotransferase activity, thereby reducing glutamate production in said medium.

US Pat. No. 10,189,806

FIBER CONDUIT APPARATUS FOR CONDUCTING CHEMICAL REACTIONS AND CHEMICAL EXTRACTIONS

Chemtor, LP., San Marcos...

1. An apparatus comprising:a conduit comprising:
two fluid inlets at one end of the conduit, wherein one of the two fluid inlets comprises a tube extending into the conduit and a perforated node at the end of the tube, and wherein the other of the two fluid inlets is arranged up-stream of the perforated node;
one fluid outlet at an opposing end of the conduit;
a collection vessel positioned proximate the fluid outlet, wherein the collection vessel comprises two fluid outlets respectively arranged along upper and lower portions of the collection vessel; and
a plurality of functionalized polymer fibers positioned longitudinally within the conduit, wherein one end of the functionalized polymer fibers are secured to the perforated node, wherein the other end of the functionalized polymer fibers extend into the collection vessel, and wherein the functionalized polymer fibers comprise acid functionalized polymer fibers, base functionalized polymer fibers, hydroxyl functionalized polymer fibers, amino functionalized polymer fibers, or ether functionalized polymer fibers.

US Pat. No. 10,189,805

METABOLISM PROBES FOR THERAPY AND DIAGNOSIS

Vanderbilt University, N...

1. A compound of the following formula:wherein:R1 is a bond, optionally substituted C1-C6 alkyl, or optionally substituted —(C1-C6 alkyl)—SO2—R2;
R2 is optionally substituted and chosen from morpholino, pyrrolidine, pyrrole, piperidine, pyridine, benzoimidazole, benzothiazole, piperazine, methyl-piperazine;
R3 is H or optionally substituted C1-C6 alkyl; and
R4 is NH2 or NHBoc;or pharmaceutically acceptable salts thereof.

US Pat. No. 10,189,804

METHOD FOR PRODUCING DICARBOXYLIC ACID COMPOUND

DAIICHI SANKYO COMPANY, L...

1. A method for producing a compound represented by formula (13) or a pharmacologically acceptable salt thereof, the method comprising:(i) a step of
1) reacting a compound represented by formula (10) or a compound represented by formula (11) with 3-(chlorosulfonyl)benzoyl chloride in a solvent to obtain a condensate, and then
2) reacting the condensate with a compound represented by formula (3) in a solvent in the presence of a base to produce a compound represented by formula (12):
wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, R3 represents a C1-C6 alkyl group, and HX represents an acid; and(ii) a step of subjecting the compound represented by formula (12) produced in the previous step to a hydrolysis reaction in the presence of aqueous alkali in a solvent to produce a compound represented by formula (13):
wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl group.

US Pat. No. 10,189,801

METHOD FOR SYNTHESIZING TETRAHYDROISOQUINOLINE THIAZOLIDINE

NATIONAL CHI NAN UNIVERSI...

1. A method for synthesizing tetrahydroisoquinoline thiazolidine of formula (III) and formula (IV):
comprising reacting, at a temperature between 20° C. and 100° C. in a solvent, a compound of Formula (II) and a compound of Formula (I):
wherein, R1 is selected from the group consisting of hydrogen, halogen, an alkyl group, and an alkoxy group;R2 is selected from the group consisting of an alkoxy group, an aryloxy group, and N(OMe)Me, wherein Me is a methyl group; and
the solvent is selected from the group consisting of tetrahydrofuran (THF), ethyl acetate (EtOAc), ethanol, dichloromethane (DCM), acetone, and acetonitrile.

US Pat. No. 10,189,798

ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM

MEDICAL TECHNOLOGY RESEAR...

1. An antimicrobial silver s-triazine compound consisting of:silver with an s-triazine ring carrying at least one substituent R and/or R1 on a nitrogen atom;
wherein R and/or R1 is not hydrogen;
wherein the antimicrobial silver s-triazine compound has one of the following chemical structures:

wherein, for structure (iv), R and R1 include one of the group consisting of a straight chain alkyl group of 1 to 20 carbon atoms, a branched alkyl group of 0.1 to 20 carbon atoms, an allyl group, a vinyl group, a napthyl group, and a heteroaryl group when R and R1 are different;
wherein, for structure (iv), R and R1 include one of the group consisting of the straight chain alkyl group of 1 to 20 carbon atoms, the branched alkyl group of 1 to 20 carbon atoms, and the napthyl group when R and R1 are identical; and
wherein, for structure (i), R includes one of the group consisting of the straight chain alkyl group of 1 to 20 carbon atoms, the branched alkyl group of 1 to 20 carbon atoms, the allyl group, the vinyl group, a phenyl group, a benzyl group, the napthyl group, and the heteroaryl group.

US Pat. No. 10,189,797

CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE

Duke University, Durham,...

1. A method of treating cancer in a subject in need thereof, the method comprisingadministering to the subject an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof,

wherein,
R1a is OR4 or NR8—SO2—R9;
R1b, R1c and R1e are hydrogen;
R1d is halogen;
A is heteroaryl selected from the group consisting of benzoimidazolyl, 1,2,4-triazolyl, indolyl, pyridinyl, pyrimidinyl, thiazolyl, and quinolinyl;
D is hydrogen, halogen, nitro, alkyl, cyano, haloalkyl, aryl or heteroaryl, selected from the group consisting of benzoimidazolyl, 1,2,4-triazolyl, indolyl, pyridinyl, pyrimidinyl, and quinolinyl with 0-5 substituents independently selected from the group consisting of hydrogen, halogen, nitro, alkyl, cyano, haloalkyl, alkoxyalkyl, heteroalkyl, alkenyl, alkynyl, heterocycle, carboxyl, heterocyclealkyl, OR4, SR5, NR6R7, and NR8—SO2—R9;
R4 is selected from the group consisting of hydrogen, —C(O)-alkyl, —C(O)-alkenyl, —C(O)-alkoxyalkyl, —C(O)-heteroalkyl, —C(O)-heteroaryl, —C(O)—O-heteroalkyl, —C(O)—O-heteroaryl, —C(O)—O-alkyl, —C(O)—O-alkenyl, —C(O)—O-alkoxyalkyl, —C(O)—NH-alkyl, and —C(O)-heterocycle;
R5, R6 and R7 are each independently selected from the group consisting of hydrogen, alkyl, —C(O)-alkyl, —C(O)-alkoxyalkyl, alkenyl, alkynyl, and heteroalkyl;
R8 is selected from the group consisting of hydrogen and alkyl; and
R9 is selected from the group consisting of hydrogen, alkyl, aryl, heteroaryl, arylalkyl, heterocycle, and heteroarylalkyl; and
wherein the cancer is breast cancer.

US Pat. No. 10,189,758

METHOD FOR PRODUCING HYDROFLUOROOLEFIN

AGC Inc., Chiyoda-ku (JP...

1. A method for producing 2,3,3,3-tetrafluoropropene, the method comprising:reacting 1,1-dichloro-2,3,3,3-tetrafluoropropene with hydrogen in the presence of a catalyst supported on a carrier, to obtain 2,3,3,3-tetrafluoropropene,
wherein the catalyst comprises alloy particles comprising at least one platinum group metal selected from the group consisting of palladium and platinum, and gold,
the proportion of the gold at the surface of the alloy particles is from 8.6 to 19.4 mass % per 100 mass % in total of the platinum group metal and the gold at the surface of the alloy particles,
the 1,1-dichloro-2,3,3,3-tetrafluoropropene and the hydrogen are introduced to a catalyst layer packed with the carrier supporting the catalyst, and
the temperature of the region at the highest temperature in the catalyst layer is from 99.7° C. to 166.4° C.

US Pat. No. 10,189,739

GLASS FOR CHEMICAL TEMPERING AND CHEMICALLY TEMPERED GLASS

AGC Inc., Chiyoda-ku (JP...

1. A glass, comprising: as represented by mole percentage based on the following oxides, from 60 to 69% of SiO2; from 12 to 20% of Al2O3; from 9 to 16.5% of Na2O; from 0 to 1% of K2O; from 0 to 13% of MgO; from 0 to less than 1% of CaO; from 0 to 1% of ZrO2; and from 0 to 6% of B2O3,wherein a liquid phase temperature of the glass is lower than a temperature T4 at which a viscosity of the glass is 104 dPa·s, and
wherein Z calculated by the following formula by using the contents, as represented by mole percentage, of SiO2, Al2O3, Na2O, MgO, B2O3 and K2O is at least 1,100,
Z2 calculated by the following formula by using the contents, as represented by mole percentage, of SiO2, Al2O3, Na2O, MgO and ZrO2 is at least 1,300, and
Z3 calculated by the following formula by using the contents, as represented by mole percentage, of SiO2, Al2O3, Na2O, MgO and ZrO2 is at most 0.150:
Z=2×SiO2+55×Al2O3+22×Na2O+15×MgO?30×B2O3?126×K2O,
Z2=3.5×SiO2+85×Al2O3+0.80×Na2O+2.0×MgO+81×ZrO2,
Z3=?0.00722×SiO2+0.0264×Al2O3+0.0149×Na2O+0.0035×MgO?0.0204×ZrO2.

US Pat. No. 10,189,692

SYSTEMS, DEVICES AND METHODS FOR RESTORING SHOPPING SPACE CONDITIONS

Walmart Apollo, LLC, Ben...

1. A system for restoring shopping space conditions comprising:a motorized transport unit comprising at least one sensor; and
a central computer system comprising a wireless transceiver for communicating with the motorized transport unit, the central computer system being configured to:
identify a section of the shopping space having a dropped item;
instruct the motorized transport unit to travel to the section of the shopping space and collect information associated with the dropped item using the at least one sensor, wherein the at least one sensor comprises a barcode or Radio Frequency Identification (RFID) reader and the information associated with the dropped item comprises an item identifier;
determine a characteristic of the dropped item in the section of the shopping space based on the item identifier detected by the at least one sensor of the motorized transport unit, wherein the characteristic is retrieved from an item characteristics database using the item identifier; and
select a cleaning task from a plurality of cleaning tasks based on the characteristic of the dropped item.

US Pat. No. 10,189,678

ELEVATOR STRIP BONDED END TERMINATION

THYSSENKRUPP ELEVATOR AG,...

1. An elevator end termination, comprising:a base member comprising a proximal end and a distal end and defining an internal belt cavity and an opening at the proximal end of the base member opening to the belt cavity, the belt cavity comprising opposing interior walls;
an elevator belt comprising an outer jacket and an internal load carrier, wherein a portion of the internal load carrier is exposed on an end of the elevator belt, wherein the exposed portion of the internal load carrier is positioned in the belt cavity;
a plate operatively connected to the base member to form the internal belt cavity, the base member and the plate pressed together to hold the exposed portion of the internal load carrier therebetween; and
an adhesive provided in the belt cavity at least between opposite sides of the internal load carrier and the opposing interior walls of the belt cavity,
wherein the elevator belt is adhesively bonded to the base member.

US Pat. No. 10,189,656

SHINGLE WITH REINFORCED NAIL ZONE AND METHOD OF MANUFACTURING

Owens Corning Intellectua...

1. A roofing shingle comprising:an overlay sheet including a mat and an asphalt coating applied to the mat, and defining an upper headlap portion and a lower tab portion;
an underlay sheet including a mat and an asphalt coating applied to the mat, the underlay sheet having a front surface secured to the overlay sheet such that a region of the underlay sheet overlaps a region of the headlap portion of the overlay sheet; and
a reinforcement material having an interior surface secured directly to the asphalt coating on the headlap portion of the overlay sheet without extending into the tab portion to provide a reinforced nail zone along a longitudinal axis of the shingle, wherein the reinforcement material is configured to improve nail pull-through, with the reinforcement material and the headlap portion providing a nail pull-through value that is greater than an otherwise identical shingle having no such reinforcement material;
wherein the interior surface of the reinforcement material is treated using one of a coating, adhesive, corona treatment, etching, perforations, and surface roughening.

US Pat. No. 10,189,581

UAV PAYLOAD MODULE CAMERA ASSEMBLY AND RETRACTION MECHANISM

AeroVironment, Inc., Mon...

1. A UAV comprising, a housing,a) a payload module comprising a deployable payload; and
b) a retraction mechanism apparatus capable of moving the payload from a stowed position within a UAV to a deployed position extending out of the UAV, the retraction mechanism being configured such that the payload retracts back into the UAV upon contact with a landing surface if the payload is not retracted before the UAV contacts the landing surface so as to reduce at least one of: (1) a probability, or (2) a severity of damage to a deployed payload upon landing.

US Pat. No. 10,189,520

MODULAR SYSTEM FOR A VEHICLE

Volkswagen Aktiengesellsc...

1. A modular system for a vehicle comprising:a selected instrument panel that extends over a width of an interior of the motor vehicle from a driver side of the vehicle to a passenger side of the vehicle;
at least one selected door that is arranged on a side of the vehicle in a pivotal manner in order to close or open a vehicle door opening adjoining the selected instrument panel;
wherein the modular system has at least two different instrument panels and/or at least two different doors for selection, wherein each instrument panel has a first joint region and each door has a second joint region,
wherein the second joint region is pivoted away from the first joint region when the at least one selected door is pivoted into an open position and the second joint region is pivoted towards the first joint region so as to adjoin the first joint region and form a unitary joint when the at least one selected door is pivoted into a closed position, and
wherein the second joint region corresponds to the first joint region such that each first joint region and each second joint region, when adjoined in the closed position of the door, always form the unitary joint with a same joint gap width therebetween.

US Pat. No. 10,189,486

RAILCAR WITH NESTED SLIDING GATES

Trinity North American Fr...

1. A railcar system comprising:a railcar; and
a nested sliding gate assembly disposed within the railcar, and comprising:
an upper deck comprising a plurality of holes;
a lower deck positioned below the upper deck, and comprising a plurality of discharge ports; and
a driving system operably coupled to the lower deck, wherein:
the driving system is configured to position the lower deck in a first position with respect to the upper deck,
the holes of the upper deck and the discharge ports of the lower deck do not align when the lower deck is in the first position,
the driving system is configured to position the lower deck in a second position with respect to the upper deck, and
the holes of the upper deck and the discharge ports of the lower deck at least partially align when the lower deck is in the second position.

US Pat. No. 10,189,439

SEAT BELT RETRACTOR AND SEAT BELT DEVICE

JOYSOFT SAFETY SYSTEMS JA...

1. A seat belt retractor provided with a spool configured to perform winding of a webbing for restraining an occupant, a shaft inserted through an axial center of the spool, and a locking base connected to the shaft and capable of switching between a rotating state and a non-rotating state, the seat belt retractor comprising:a load adjustment member disposed between the shaft and the locking base and configured to block or reduce load transmission in a case where a load equal to or greater than a threshold is applied to the shaft; and
an energy absorption device disposed between the spool and the locking base and capable of changing an energy absorption amount according to a relative rotation speed between the spool and the locking base, wherein the energy absorption device is connected in parallel with the load adjustment member, and wherein the energy absorption device includes a housing coaxially disposed on a spool side, a clutch plate coaxially disposed on a locking base side, and a drag generation member housed inside the housing and configured to generate drag according to a relative rotation speed between the housing and the clutch plate, and
wherein
the housing has a pair of facing planes facing a front surface and a back surface of the clutch plate, wherein annular corrugated grooves are formed on the pair of facing planes such that projections and recesses thereof are synchronous with each other,
the drag generation member includes a plurality of driving pins having both ends thereof inserted into the corrugated grooves, and
the clutch plate has a plurality of openings through which the plurality of driving pins is inserted so as to be capable of moving along the corrugated grooves.

US Pat. No. 10,189,416

STORAGE COMPARTMENT FOR A VEHICLE INTERIOR TRIM

Volkswagen Aktiengesellsc...

1. A storage compartment for an interior trim of a vehicle, the storage compartment comprising:a storage-compartment bottom that transitions at an inner corner region into a side wall that is raised from the storage-compartment bottom; and
an insertion mat lining the storage-compartment bottom, the insertion mat forming a support surface for at least one small object, the insertion mat at least partially bounds at least one free deformation chamber, and when manual pressure via a fingertip is applied to the support surface, the insertion mat curves into the deformation chamber by arching such that between the deformed support surface and the object, an undercut for grasping under the object is accessible to the fingertips.

US Pat. No. 10,189,305

BICYCLE FRONT WHEEL HUB WITH TORQUE TUBE

SRAM, LLC, Chicago, IL (...

1. A hub and fork assembly for a bicycle, comprising:a hub, comprising:
a hub body,
a torque tube disposed in the hub body,
a first outer end face of the torque tube having a first boss, and
a second outer end face of the torque tube having a second boss;
a fork, comprising:
a first hub engaging member having a first anti-rotation fork feature, and
a second hub engaging member having a second fork anti-rotation feature, the second fork anti-rotation feature extending axially towards the first fork anti-rotation feature,
wherein each hub engaging member is a closed ring;
a first hub anti-rotation feature non-rotatably engaged with the first fork anti-rotation feature and the first boss of the first outer end face of the torque tube;
a second hub anti-rotation feature non-rotatably engaged with the second fork anti-rotation feature and the second boss of the second outer end face of the torque tube; and
a skewer passing through the first hub engaging member of the fork, the first outer end face of the hub, the second outer end face of the hub, and the second hub engaging member of the fork.

US Pat. No. 10,189,304

HUB FOR A BICYCLE

SRAM Deutschland GMBH, S...

1. A hub for a bicycle, comprising:a hub axle,
a hub sleeve which is mounted rotatably on the hub axle,
a driver which is mounted rotatably on the hub axle via a bearing arrangement and is coupleable to the at least one hub sleeve in a torque-transmitting manner, wherein the bearing arrangement has at least one axially inner bearing and at least one axially outer bearing,
further comprising at least one fastening element, which fixes at least the inner bearing of the bearing arrangement in its predetermined position on the hub axle by a local enlargement of the cross section of the hub axle, the at least one fastening element having at least one portion which is configured in a manner corresponding to the contour on the inner circumferential surface of the hub axle,
wherein the hub axle has a radially inward protruding protrusion having an inclined counterpart abutment surface on at least a portion of its inner circumferential surface, said contour interacting with the at least one fastening element, and
wherein the at least one portion, corresponding to the contour on the inner circumferential surface, of the fastening element has an inclined abutment surface.

US Pat. No. 10,189,303

BICYCLE RIM FOR TUBELESS TIRE

HED CYCLING PRODUCTS, INC...

1. A bicycle rim assembly comprising:a bicycle rim comprising:
a center channel that is continuous from a channel first outer sidewall to a channel second outer sidewall, the channel first outer sidewall disposed to a first side of a centerline of the rim and the channel second outer sidewall disposed to a second side of the centerline of the rim, the channel having a channel diameter;
a pair of rim sidewalls disposed at the lateral peripheries of the bicycle rim;
a pair of bead seats disposed proximate to the rim sidewalls and having a bead seat diameter;
an attachable annular strip formed separately from the bicycle rim and attached to the bicycle rim along a center line of the center channel, the attachable annular strip comprising:
a set of strip sidewalls;
a center section extending between the strip sidewalls, wherein the strip sidewalls are spaced at less than a center channel width such that the strip forms a pair of bead channels in cooperation with the channel first outer sidewall and channel second outer sidewall, the bead channels positioned laterally inward of the bead seats, the pair of bead channels having a bead channel diameter that is less than the bead seat diameter, and the center section having a radially outer surface with a diameter that is greater than the bead seat diameter.

US Pat. No. 10,189,299

SYSTEM FOR MOUNTING A COVERING UPON A FRAME

Tracer Imaging LLC, Ossi...

1. A frame for maintaining a region of a fabric piece in a substantially planar state, comprising:a plurality of rails, each of said rails having a geometrical profile extended in a linear direction, said rails each having a first end face and a second end face, and
a plurality of corner pieces, each of said corner pieces including a slot formed partially through said corner piece at a miter angle, wherein the plurality of corner pieces exclusively define all corners of the frame and are separate parts relative to the plurality of rails, each slot being defined and formed only in a respective corner piece and not in the plurality of rails.

US Pat. No. 10,189,223

BEAD FORMING APPARATUS AND FORMING METHOD

FUJI SEIKO CO., LTD., Ha...

1. A bead forming apparatus comprising:a rotatable drum having a plurality of divided bodies dividedly arranged along a circumference of the rotatable drum and being adapted to be wrapped with a belt-shaped bead filler having a short base and two other long sides, around the rotatable drum in an annular shape;
a plurality of erection arms provided along the circumference and respectively swingably supported around respective pivots by the divided bodies of the rotatable drum so as to erect the bead filler by swinging the erection arms;
a swing device for swinging the erection arms, the swing device including a plurality of link mechanisms connected to the plurality of erection arms, respectively, and an actuating device comprising a plurality of cylinder devices, each having a respective piston rod, and an actuating member in the form of a ring placed at an end of the piston rods; and
a plurality of slide members provided as contact portions of the erection arms that come into contact with the bead filler so that the bead filler can be radially slidable relative to the erection arms,
wherein the plurality of slide members is formed by a plurality of rotatable rollers rotatably provided in a longitudinal direction of the plurality of erection arms so as to be rotatable about axes that are parallel to the respective pivots of the respective erection arm,
wherein each of the link mechanisms includes
a push bar that is slidable horizontally inside a guide member that is provided inside a respective divided body of the plurality of divided bodies,
a protrusion protruding from a respective erection arm of the plurality of erection arms, and
a link pivotally connected to the push bar at a first end of the link and pivotally connected to the protrusion at a second end of the link,
wherein the actuating device can achieve a first retracted position at which the actuating member is not in contact with the push bars while the plurality of erection arms are in a horizontal state, and
wherein the actuating device can move from the first position to a second, extended position at which the actuating member is in contact with a free end of each of the push bars so as to cause the erection arms to become erected by moving the second end of the links to be radially further from an axis of rotation of the rotatable drum in the second position of the actuating device than in the first position of the actuating device; the bead forming apparatus further comprising a diameter changing mechanism for changing a diameter of the rotatable drum as well as changing a radial distance of the push bars from the axis of rotation.

US Pat. No. 10,189,222

DEVICE FOR SUPPLYING TIRE-CONSTITUTING MEMBER, METHOD FOR SUPPLYING TIRE-CONSTITUTING MEMBER, AND METHOD FOR MANUFACTURING UNVULCANIZED TIRE

BRIDGESTONE CORPORATION, ...

1. A device for supplying a tire-constituting member which supplies a tire-constituting member to the front side of a molding drum, comprising:a placement portion to which the tire-constituting member is supplied from the rear side so as to be placed on the placement portion;
a first holder which is disposed so as to hold a front end portion of the tire-constituting member and is disposed so as to be movable; and
a second holder which is disposed so as to hold a rear end portion of the tire-constituting member cut to a predetermined length and is disposed so as to be movable;
wherein the first holder and the second holder hold the tire-constituting member that is cut to the predetermined length and is positioned on the placement portion, and supply the tire-constituting member to the front side,
the device further comprising:
a detector configured to detect positions of two corner portions of the front end portion of the tire-constituting member placed on the placement portion; and
a control unit which calculates a deviation amount of the two corner portions of the front end portion with respect to two preset reference positions of the two corner portions of the front end portion of the tire-constituting member according to data from the detector and drives the first holder in a state where the rear end portion of the tire-constituting member is held by the second holder such that the two corner portions of the front end portion of the tire-constituting member are positioned at the two reference positions of the two corner portions of the front end portion so as to eliminate the deviation amount of the two corner portions of the front end portion according to the calculation results.

US Pat. No. 10,189,218

THERMAL COMPOSITE MATERIAL REPAIR UTILIZING VACUUM COMPRESSION

The Boeing Company, Chic...

1. An apparatus comprising:a flexible vacuum compression device for thermally curing a potting material within a hole in a surface of a composite material, the flexible vacuum compression device including:
a first end that is closed;
a second end opposite the first end that is open to form a cavity between the first end and the second end, wherein the second end includes an interface that is configured to generate an air tight seal when applied to the surface;
a partition, which extends from and is connected to a side wall of the flexible vacuum compression device, that traverses at least partially across the cavity to form a compartment within the cavity; and
a vacuum port having a passage through the first end and into the cavity;
a breathable insulator disposed within the compartment; and
a chemical-based heating pack disposed between the breathable insulator and the partition;
wherein a bottom surface of the partition includes a breathable pattern that, upon application of a vacuum source to the vacuum port, draws a vacuum within the cavity to cause the cavity to collapse and press the chemical-based heating pack and the partition proximate to the surface to thermally cure the potting material.

US Pat. No. 10,189,216

PROCESS AND APPARATUS FOR MOLDING COMPOSITE ARTICLES

1. A process for molding a composite article, the process comprising:placing reinforcing materials in or on a mold;
infusing the reinforcing materials with a matrix until the matrix-infused reinforcing materials are saturated with the matrix;
starting transmitting ultrasounds to the matrix-infused reinforcing materials when the matrix-infused reinforcing materials are saturated with the matrix, wherein the ultrasounds comprise ultrasounds in a first range of frequencies and ultrasounds in a second range of frequencies than the first range of frequencies;
stopping transmitting ultrasounds to the matrix-infused reinforcing materials before the matrix begins gelation.

US Pat. No. 10,189,202

BLOW MOLDING DEVICE

1. A blow molding device for blow forming a resin preform into a container of a predetermined shape, comprising:a mold having an opening configured to receive the preform therein for blow forming;
a cylindrical nozzle that is moveable between a retracted position and an inserted position in which the nozzle is inserted into a mouth part of the preform;
a pressurized fluid supply part configured to supply a pressurized incompressible fluid to the nozzle via a supply channel;
a sealing body that is movable between a closed position that contacts and closes the nozzle and an open position that is apart from and opens the nozzle;
a plurality of suction holes provided in at least two rows on an inner peripheral surface of the nozzle and positioned toward an axial end of the nozzle that is inserted into the mouth part of the preform;
a vertical hole extending along an axial direction of the nozzle and connecting a plurality of the suction holes to each other, and
a suction pump connected to the vertical hole via a suction path and configured to apply a suction force to a plurality of the suction holes for suctioning incompressible fluid adhered to the nozzle.

US Pat. No. 10,189,201

METHOD FOR MANUFACTURING A HOLLOW BODY, IN PARTICULAR A FUEL TANK

Plastic Omnium Advanced I...

1. A method for manufacturing a hollow body from a plastic material, said method comprising:molding a preform into shells in a molding tool;
joining an insert to an inner surface of a shell of said shells, said insert defining a sub volume within the hollow body to be made; and
joining together the shells to form the hollow body by closing the molding tool and applying a main pressure to a main volume enclosed by the shells,
wherein a sub pressure is applied to the sub volume while the main pressure is applied to the main volume, such that a pressure difference between the main volume and the sub volume is bigger than 0.20 bar and smaller than 3.00 bar, and
wherein a contour of the insert is defined by a wall and the insert is selected from a line, a valve, a liquid pump, a nipple, a baffle, a ventilation device and a liquid trap.

US Pat. No. 10,189,198

MULTI-LAYER HOSE AND HOSE FORMULATION

Swan Products, LLC, Sand...

1. A garden hose comprising:an extruded composite tube including a core layer and a jacket layer of a polyvinyl chloride (PVC) compound;
an intermediate reinforcement layer disposed between the core layer and the jacket layer, the intermediate reinforcement layer comprising one or more spiraled, braided or fabric filaments wound around the core layer to thereby define a plurality of diamond-shaped interstices; and
a tie layer disposed between the core layer and the jacket layer, such that the tie layer flows through the plurality of diamond-shaped interstices to fuse the core layer to the jacket layer;
wherein:
the PVC compound comprises:
100 PPH (parts in weight per hundred parts of resin) of PVC resin; and
45-75 PPH of plasticizer;
the PVC compound has a K value in a range of 79-85 measured according to standard ISO1628-2 and a specific gravity in a range of 1.17-1.23 measured according to standard ASTM D792;
the composite tube has a circular cylindrical cross-section and a wall thickness in a range of 115 to 145 mils (thousandths of an inch); and
a 12 inch length of the composite tube at zero fluid pressure maintains its circular cylindrical cross-section without kinking at a bend radius of less than 3 inches and the composite tube has a minimum burst pressure of 500 psi measured according to standard ISO 1402:2009.

US Pat. No. 10,189,197

SOFT AND VELVET TOUCH BARRIER LAMINATE

ESSEL PROPACK LIMITED, M...

1. A soft and velvet touch barrier laminate comprising:(a) a printable layer comprising a polypropylene elastomer;
(b) a core layer adjacent to the printable layer;
(c) a laminating layer adjacent to the core layer;
(d) a barrier layer between first and second bond layers, wherein the first bond layer is between the laminating layer and the barrier layer; and
(e) an inner polyethylene (PE) layer adjacent to the second bond layer which is in contact with the barrier layer;
wherein said polypropylene elastomer has Vicat softening temperature in the range of 60° C. to 90° C., wherein the printable layer further comprises high density polyethylene (HDPE); an anti-block additive; and a colorant.

US Pat. No. 10,189,193

METHOD FOR THE PRODUCTION OF A FLUID CONTAINER FOR A MOTOR VEHICLE, AND CORRESPONDING FLUID CONTAINER

AUDI AG, Ingolstadt (DE)...

12. A fluid container for a motor vehicle, said fluid container comprising:at least two shaped shells connected to one another and each formed as a unitary, single-layer component, each of the shells forming both an interior surface and an exterior surface of the fluid container, each of the shells having a single planar bottom and sidewalls extending from the bottom at an angle in relation to the bottom away from the bottom and a plurality of projections in spaced-apart relation to one another and to the sidewalls, with the plurality of projections being injection-molded off-tool.

US Pat. No. 10,189,191

COLLECTION OF PROCESS DATA USING IN-SITU SENSORS

THE BOEING COMPANY, Chic...

1. A system for molding a composite layup inside an autoclave, comprising:a mold tool;
a vacuum bag sealed to the mold tool and having a plurality of openings therein at different sensing locations on the vacuum bag;
a plurality of first MEMS vacuum pressure sensors attached to the vacuum bag and respectively coupled through the openings to an interior of the vacuum bag;
at least one opening in the mold tool;
a second MEMS vacuum pressure sensor mounted within the opening in the mold tool and configured to sense either a vacuum pressure or a fluid pressure inside the at least one opening in the mold tool; and
a processor configured to be placed inside the autoclave and to collect and process pressures sensed by the plurality of first MEMS vacuum pressure sensors and the second MEMS vacuum pressure sensor.

US Pat. No. 10,189,190

METHOD FOR PRODUCING A STRUCTURAL COMPONENT, PARTICULARLY FOR A VEHICLE BODY

THYSSENKRUPP STEEL EUROPE...

1. A method for producing a structural component for a vehicle body, the method comprising:providing a flat carrier material made of a metal and one of a thermoplastic material or a fiber-reinforced thermoplastic material to give a three-dimensional component; and
providing the carrier material with a supporting material made of a thermoplastic material, such that the carrier material and the supporting material form an integral material composite, wherein the carrier material is in the form of a multi-layer material composite, one of the layers of the multi-layer material composite consisting of metal, wherein the material composite made up of the carrier material and the supporting material is produced before the carrier material is processed to give the three-dimensional component, the layer thickness of the supporting material being at least twice the thickness of the multi-layer carrier material,
after the material composite is formed, heating the material composite before the processing in order to make processing of the thermoplastic material possible, wherein a rib structure is impressed into the supporting material simultaneously during the three-dimensional forming of the material composite, and wherein the temperature of the three-dimensional component having the rib structure is controlled.

US Pat. No. 10,189,188

NANOIMPRINT LITHOGRAPHY ADHESION LAYER

Canon Kabushiki Kaisha, ...

1. A compound of Formula A-1:
wherein n is an integer and R is C1-10 alkyl.

US Pat. No. 10,189,186

METHOD FOR FINISHING MATCHING SURFACES IN FORMING TOOL COMPONENTS

Ford Global Technologies,...

1. A tool-forming method comprising steps of:providing a core and a cavity that include respective core and cavity shutoff bands, the core and cavity being made entirely of steel with mating core and cavity parting planes that extend respectively therethrough;
removing portions of the core and cavity shutoff bands that are distal from the core and cavity parting planes;
stress relieving the core and cavity through tempering, wherein the core and cavity are heated to a temperature of from 550 degrees Celsius to 660 degrees Celsius, and wherein the core and cavity are then cooled at a slow rate to achieve a consistent hardness through the steel of the core and the cavity; and
refining exposed steel surfaces of the respective core and cavity shutoff bands, wherein the steel of the core and the steel of the cavity are removed to expose the core and cavity parting planes.

US Pat. No. 10,189,184

METHODS FOR MANUFACTURING THREE-DIMENSIONAL DEVICES AND DEVICES CREATED THEREBY

UNITED TECHNOLOGIES CORPO...

37. An assembly comprising:a metallic foil stack lamination mold; and
a cast component that fills a cavity of said metallic foil stack lamination mold, said cast component comprising a plurality of component surfaces, a predetermined component surface from said plurality of component surfaces having a predetermined surface condition;
wherein:
said cavity defines a single demolding opening for said mold;
said demolding opening defines a demolding direction in which said cast component is removable via said demolding opening from said cavity of said mold with damage to neither said cast component nor said mold;
said cavity defines a first cavity cross-sectional area that extends solely within a first cavity plane that is oriented perpendicularly to said demolding direction;
said cavity defines a second cavity cross-sectional area that extends solely within a second cavity plane that is oriented perpendicularly to said demolding direction;
said first cavity cross-sectional area is smaller than said second cavity cross-sectional area; and
said first cavity plane is closer to said demolding opening than said second cavity plane.

US Pat. No. 10,189,183

METHOD AND APPARATUS ARRANGEMENT FOR MIXING SILICONE COMPOSITION

Oy Pro-Hydro Ab, Tornio ...

1. A method for manufacturing a silicone composition, in which methoda pumping of different silicone composition subcomponents is started;
the silicone composition subcomponents are pumped with component-specific pumps to a mixer of silicone composition subcomponents;
a silicone composition is mixed from the subcomponents with the mixer;
the process for manufacturing silicone composition is stopped due to downtime;
wherein
the silicone composition mixer is cooled to a temperature, in which a chemical reaction between the different subcomponents of the silicone composition stops;
the silicone composition mixer is kept at the cooling temperature for a duration of the downtime; and that
the manufacture of the silicone composition is continued after the downtime without cleaning the mixer.

US Pat. No. 10,189,182

PROCESSING SYSTEM

DISCO Corporation, Toky...

1. A processing system comprising:a processing apparatus having functional units including a holding unit that holds a workpiece by a holding surface, a processing unit that processes the workpiece held by the holding unit, and a feed unit that moves the holding unit and the processing unit relatively;
a detecting unit that is provided for part or all of the functional units and detects any of vibration, current, voltage, load, speed, torque, pressure, temperature, flow rate, change in a taken image, and thickness of the workpiece; and
a data accumulating unit that accumulates information included in a signal output from the detecting unit as accumulated data,
the processing apparatus further comprising,
a determining unit that determines states of the functional units on the basis of the accumulated data in the data accumulating unit, and
a normal data storing unit that stores information included in a signal output from the detecting unit when the functional units are normal based on a predetermined condition as normal data;
the determining unit comparing the accumulated data in the data accumulating unit and the normal data stored in the normal data storing unit and determining the states of the functional units,
wherein the processing apparatus is a cutting apparatus including, as the processing unit, a cutting unit in which a cutting blade that carries out cutting processing of the workpiece held by the holding unit is mounted,
the cutting apparatus includes a vibration detecting unit that detects vibration of the cutting blade as the detecting unit,
information on vibration when cutting processing of the workpiece is carried out by the cutting blade is accumulated in the data accumulating unit as the accumulated data,
information on vibration when cutting processing of the workpiece is carried out by a proper cutting blade corresponding to the workpiece is stored in the normal data storing unit as the normal data, and
the determining unit compares the accumulated data in the data accumulating unit and the normal data stored in the normal data storing unit and determines whether or not cutting processing of the workpiece is normally carried out.

US Pat. No. 10,189,181

METHOD FOR SLICING WORKPIECE AND PROCESSING LIQUID

SHIN-ETSU HANDOTAI CO., L...

1. A method for slicing workpieces, comprising:forming a wire row by a wire spirally wound between a plurality of wire guides and traveling in an axial direction,
pressing a workpiece against the wire row while supplying a processing liquid comprising abrasive grains to a contact portion between the workpiece and the wire to slice the workpiece and thereby producing a waste slurry comprising at least a portion of the abrasive grains,
recovering at least a portion of the abrasive grains from the waste slurry,
subjecting the recovered abrasive grains to a treatment with a mixed liquid of sulfuric acid and hydrogen peroxide,
dispersing the treated abrasive grains into coolant to make a reused processing liquid, and
reusing the treated abrasive grains in the reused processing liquid for slicing of another workpiece.

US Pat. No. 10,189,180

FOAM INJECTION SYSTEM WITH VARIABLE PORT INSERTS FOR SLURRY MIXING AND DISPENSING APPARATUS

United States Gypsum Comp...

1. A foam injection system for a cementitious slurry mixing and dispensing assembly, the foam injection system comprising:a foam injection body, the foam injection body defining a slurry passageway and a first port passageway, the first port passageway having a port opening in fluid communication with the slurry passageway, the foam injection body including a body engaging surface;
a first port insert, the first port insert defining a first foam passageway having a first orifice with a first orifice size, the first port insert adapted to removably mount to the foam injection body such that the first foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway, the first port insert including a port insert engaging surface adapted to engage the body engaging surface of the foam injection body when the first port insert is mounted thereto such that the first foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway; and
a second port insert, the second port insert defining a second foam passageway having a second orifice with a second orifice size, the second port insert adapted to removably mount to the foam injection body instead of the first port insert such that the second foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway, and the second orifice size being different than the first orifice size, the second non insert including the port insert engaging surface such that the port insert engaging surface of the second port insert is adapted to engage the body engaging surface of the foam injection body when the second port insert, instead of the first port insert, is mounted to the foam injection body such that the second foam passageway is in fluid communication with the slurry passageway via the port opening of the first port passageway.

US Pat. No. 10,189,177

ENGINEERED TIMBER PRODUCTS, COMPONENTS AND METHODOLOGIES

Wood Engineering Technolo...

1. A method of drying a plurality of sticks of square or rectangular cross-section, said method comprising or including the steps ofadvancing the sticks laterally onto an underlying frame of a plurality of frames comprising at least one adjacent pair of frames, each adjacent pair of frames receiving said plurality of sticks, which will allow drying of the underlying surface of the sticks,
squeezing the sticks when laterally received on the underlying frame to said underlying frame using an overlying frame carrying spaced penetrative members, said overlying frame with spaced penetrative members penetrating the upper surfaces of the sticks allowing drying of the upper most surface of the sticks, and
allowing and/or causing drying to occur whilst the sticks are so constrained by such squeezing;
wherein each adjacent pair of frames is actuatable to constrain said sticks;
wherein each underlying frame is skeletal; and
wherein a spacing of rails or bars of each frame are closer together near ends of said sticks than centrally of said sticks.

US Pat. No. 10,189,176

AUTOMATED APPARATUS FOR CONSTRUCTING ASSEMBLIES OF BUILDING COMPONENTS

Williams Robotics, LLC, ...

1. A system for constructing wall panels comprising a plurality of structural members, the system comprising:a source of structural members of predetermined size;
a horizontal table configured to support structural members as the structural members are being formed into a wall panel, the table including a stationary section and a movable carriage that is configured to move in a longitudinal direction toward and away from the stationary section;
an articulated arm unit having a gripper, the articulating arm unit positioned to retrieve structural members from the source with the gripper and place them on the table;
at least one first clamping unit fixedly mounted to the stationary section for clamping structural members thereto;
at least one second clamping unit fixedly mounted to the movable carriage for clamping structural members thereto; and
a controller that controls the movement of the articulating arm unit and the movable carriage.

US Pat. No. 10,189,175

CHAINSAW GUIDE BAR NOSE ASSEMBLY

Global GB Asia Ltd., Cen...

1. A chainsaw guide bar comprising a guide bar body and a nose assembly,wherein the nose assembly comprising
a pair of nose side plates used in a chainsaw guide bar, wherein at least one inside surface of each of the pair of nose side plates has one or more lubricant conveying channels; and
a sprocket and bearing assembly adapted to be clamped between the pair of nose side plates and comprising a saw chain-rotatable idler sprocket;
wherein the at least one inside surface of the pair of the nose side plates is disposed to face the sprocket and bearing assembly and is configured to provide lubricant via the one or more lubricant conveying channels to the sprocket and bearing assembly, and
the nose assembly is detachably attached to the guide bar body, the one or more lubricant conveying channels defined on at least one inside surface of the pair of nose side plates are connected with a corresponding lubricant conveying channel defined in a periphery of the guide bar body.

US Pat. No. 10,189,174

PORTABLE CUTTING TOOL

POSITEC POWER TOOLS (SUZH...

1. A portable cutting tool, comprising:a blade;
a motor for driving the blade to rotate, wherein the motor comprises an output shaft;
a guard assembly comprising an upper guard for receiving the blade and a lower guard, wherein the lower guard is rotatable relative to the upper guard to expose the blade to cut a workpiece;
a base pivotally connected to the upper guard, wherein the base is provided with a blade through-hole for the blade to pass through, and further comprises a base bottom portion for abutting against the workpiece and a front side wall extending upwards from the base bottom portion;
a housing, comprising:
a front portion having a case wall presenting an external surface, with a first section of the external surface facing outwardly in a first direction to define a left outside of the front portion, and with a second portion of the external surface facing outwardly in a second direction opposite the first direction to define a right outside of the front portion,
a rear portion extending longitudinally, and
a gripping portion disposed between the front portion and the rear portion,
wherein the blade is rotatably disposed on the front portion by a blade shaft, the motor is rotatably disposed in the rear portion, and the blade shaft is perpendicular to the output shaft; and
a supporting member connected to the base, and the supporting member comprising a depth adjusting holder, wherein one of the upper guard and the depth adjusting holder is disposed on the left outside of the front portion of the housing along the external surface and the other one of the upper guard and the depth adjusting holder is disposed on the right outside of the front portion of the housing along the external surface.

US Pat. No. 10,189,170

LOCKING FOLDING KNIFE

1. A locking folding knife, comprising:a handle;
a blade pivotally connected to said handle, wherein said blade has a cutting edge and a first position in which at least a portion of said cutting edge is located within said handle and a second position in which a majority of said cutting edge is outside of said handle;
a pocket defined in a first surface of said handle;
a through-cut in said pocket, wherein said through-cut terminates in said pocket at an endpoint; and
a lock integral with said handle and extending from said endpoint of said through-cut, wherein said lock engages with a portion of said blade in said second position.

US Pat. No. 10,189,169

COLLAPSING BLADE

1. A collapsible blade comprising:a frame construction, said frame construction comprising two handle sections joined at their respect rears by a pivot;
a forward blade and rear blade pivotally connected to each other;
a set of arms pivoted on a lower of the two handle sections, wherein said arms are capable of occupying folded and extended positions; wherein when the arms are in their folded positions they are confined within the handle sections;
wherein the forward blade is pivotally connected to the arms;
wherein when the collapsible blade is in a fully folded configuration, the forward blade is located internally between the two handle sections and movement of the frame away from the forward blade extends said arms and creates a quadrilateral configuration of the two handle sections, the arms and the rear blade; and
wherein continued movement of the two handle sections pivotally towards each other after reaching the quadrilateral configuration causes the collapsible blade to have a fully extended and lockable position.

US Pat. No. 10,189,167

SUCTION DEVICE, HOLDING DEVICE, AND CONVEYANCE METHOD

MITSUBISHI HEAVY INDUSTRI...

1. A suction device adapted to be attached to a leading-end section of an articulated drive mechanism and adapted to be attached by suction to a plate-shaped structural member having a curvature at least in a predetermined direction, the suction device comprising:a support part configured to be attached to the leading-end section of the articulated drive mechanism;
a pair of suction mechanisms comprising a pair of suction surfaces and disposed apart from each other in a first direction with an attachment position of the support part interposed between the pair of suction mechanisms; and
a pair of first angle adjustment mechanisms configured to adjust an angle of inclination, with respect to the first direction, of each of the pair of suction surfaces of the pair of suction mechanisms,
wherein each of the pair of first angle adjustment mechanisms comprises:
a plate-shaped member having a bottom surface to which a corresponding one of the pair of suction mechanisms is attached,
a rocking member attached to an upper surface of the plate-shaped member,
a support shaft inserted into a through-hole of the rocking member,
a pair of first angle adjustment members attached to a bottom surface of the support part,
a pair of fixing pins inserted into female screws that are fastening holes of the pair of first angle adjustment members, and
a second angle adjustment member attached to the bottom surface of the support part and supporting the support shaft.

US Pat. No. 10,189,166

SUCTION EQUIPMENT

HARMOTEC CO., LTD., Kofu...

1. Suction equipment comprising:a columnar main body;
a flat end face formed at the main body;
a concave part formed at the end face;
a fluid flow-forming means for forming a fluid swirl flow in the concave part or forming a radial flow by discharging fluid into the concave part, the fluid swirl flow or the radial flow generating negative pressure that applies suction to a member;
a baffle plate including a hole formed at a center of the baffle plate such that the hole opens toward the member, the hole allowing the fluid, to which suction has been applied due to the negative pressure, to pass through and prevent the member from entering the concave part; and
at least one support member supporting the baffle plate so that the baffle plate opposes the concave part, the at least one support member forming a flow path for the fluid to flow out of the concave part between the end face and the baffle plate.

US Pat. No. 10,189,164

ROBOT, CONTROL DEVICE, AND ROBOT SYSTEM

Seiko Epson Corporation, ...

1. A robot comprising:a plurality of arms including first, second, and third arms, a total number of the plurality of arms being n, the first, second, and third arms being rotatable around first, second, and third axes, respectively;
a plurality of motors that respectively drive the plurality of arms, a total number of the plurality of motors being n, each motor being respectively provided in a corresponding one of the plurality of arms, the plurality of motors including first, second, and third motors, the first, second, and third motors driving the first, second, and third arms, respectively;
a plurality of encoders that respectively detect positions of the plurality of arms so as to provide detection signals, a total number of the plurality of encoders being n, each encoder being respectively provided in a corresponding one of the plurality of arms, the plurality of encoders including first, second, and third encoders, the detection signals including first, second, and third position detection signals, the first, second, and third encoders detecting the positions of the first, second, and third arms so as to provide the first, second, and third position detection signals, respectively;
a plurality of signal lines through which the detection signals detected by the plurality of encoders flow, a total number of the plurality of signal lines being L, the plurality of signal lines including first and second signal lines; and
a plurality of controllers that are configured to receive the position detection signals via the plurality of signal lines so as to control driving of the plurality of motors, a total number of the plurality of controllers being m, the plurality of controllers including first and second controllers,
wherein 2?L wherein the first and second position detection signals flow only through the first signal line, and the third position detection signal flows only through the second signal line, and
the first and third position detection signals are received only by the first controller so that the first controller is configured to control the driving of the first and third motors, and the second position detection signal is received only by the second controller so that the second controller is configured to control the driving of the second motor.

US Pat. No. 10,189,163

CONTROL APPARATUS, CONTROL SYSTEM, CONTROL METHOD, AND STORAGE MEDIUM

SHARP KABUSHIKI KAISHA, ...

1. A control system comprising:a control apparatus; and
a control target controlled by the control apparatus, wherein
the control apparatus includes:
a control signal generation unit which generates a control signal;
an additional signal generation unit which generates an additional signal corresponding to the control signal generated by the control signal generating unit, the additional signal corresponding to the control signal being generated from by a predetermined arithmetic operation scheme;
a transmission unit which transmits a transmit signal including the control signal and the additional signal corresponding to the control signal to the control target via wireless communication; and
a communication switch which has a first communication disabled state and a communication enabled state, makes a transition from the first communication disabled state to the communication enabled state by a maneuver from outside, and returns to the first communication disabled state when released from the maneuver, the communication switch enabling wireless communication by the transmission unit during a period of being kept in the communication enabled state, and disabling wireless communication by the transmission unit during a period of being kept in the first communication disabled state, and
the control target includes:
an operation unit;
a reception unit which receives the transmit signal from the transmission unit and outputs a receive signal;
an operation control unit which controls the operation unit based on the control signal included in the receive signal as corresponding to the control signal in the transmit signal; and
a safety control unit which generates a new additional signal from the control signal in the receive signal by the predetermined arithmetic operation scheme, determines whether the newly-generated additional signal matches the additional signal included in the receive signal which includes the control signal used to generate the newly-generated additional signal, and forcibly controls operation of the operation unit when determining that the newly-generated additional signal does not match the additional signal.

US Pat. No. 10,189,156

INDUSTRIAL ROBOT

KAWASAKI JUKOGYO KABUSHIK...

1. An industrial robot, comprising:a base portion;
an arm unit provided to the base portion; and
an arm drive unit for driving the arm unit;
wherein the arm unit has a lower arm mechanism including a parallel link structure, and an upper arm mechanism provided to a top portion of the lower arm mechanism,
wherein the lower arm mechanism has a front link including a lower end rotatably connected to the base portion and a rear link including a lower end rotatably connected to the base portion,
wherein the arm drive unit has a lower arm drive mechanism for driving the lower arm mechanism,
wherein the lower arm drive mechanism has a lower ball screw including a nut and a shaft, and a lower bearing portion supporting the shaft so as to be rotatable about its axis,
wherein an extending portion extending from the lower end of either one of the front link and the rear link is connected to the nut so as to be rotatable about a nut side rotational axis,
wherein the lower bearing portion is connected to the base portion so as to be rotatable about a bearing portion side rotational axis,
wherein the nut side rotational axis and the bearing portion side rotational axis are parallel with rotational axes of the front link and the rear link,
wherein the lower arm mechanism has a lateral link including both ends rotatably connected to an upper end of the front link and an upper end of the rear link, respectively,
wherein the upper arm mechanism is connected to the lateral link so as to be rotatable about an upper arm rotational axis,
wherein the arm drive unit has an upper arm drive mechanism for driving the upper arm mechanism,
wherein the upper arm drive mechanism has an upper ball screw including a nut and a shaft, and an upper bearing portion supporting the shaft of the upper ball screw so as to be rotatable about its axis,
wherein the upper arm mechanism is connected to the nut of the upper ball screw at a position different from the upper arm rotational axis so as to be rotatable about a nut side rotational axis,
wherein the upper bearing portion is connected to the lateral link so as to be rotatable about a bearing portion side rotational axis, and
wherein the nut side rotational axis and the bearing portion side rotational axis of the upper ball screw are parallel with the upper arm rotational axis.

US Pat. No. 10,189,155

TOOL COUPLING ARRANGEMENT

The Ames Companies, Inc.,...

1. A coupling for an elongated handle and a tool head, the tool head having a tool head shank supporting tool body, the tool head shank having an opening extending through the tool head shank, the coupling comprising:a plug member;
a ferrule; and
a pin member,
wherein the plug member further comprises an elongated passage formed therein that is configured to receive the tool head shank, the elongated passage being in communication with a pair of aligned mount grooves;
wherein the plug member is partially received within the ferrule, and
wherein the pin member is configured to extend through the opening of the tool shank and seated within the aligned mount grooves of the plug member when the tool head shank is mounted in the channel to secure the tool head shank to the plug member and ferrule.

US Pat. No. 10,189,154

POWER TOOL

1. A Power tool, comprising:a housing having at least two housing parts, each housing part having an inner portion defining a recess therein;
a bearing located in the housing, the bearing having an outer race, wherein the respective recesses of the two housing parts mate around the outer race of the bearing and come in direct contact with the outer race of the bearing to support the bearing inside the housing; and
a seal comprising an elongate seal member located between the housing parts to seal at least a portion of the housing;
wherein the seal includes at least one polymeric extension part extending from the elongate seal member between the two housing parts and in direct contact with the outer race of the bearing without extending around the bearing, so as to prevent the outer race of the bearing from rotating with respect to the housing during use of the power tool.

US Pat. No. 10,189,153

LEVELING DEVICE ASSEMBLY FOR A HYDRAULIC HAMMER

1. A leveling device assembly for a hydraulic hammer comprising:a control unit;
a leveling sensor in communication with the control unit;
a laser generator in communication with the control unit and configured to produce a first colored light beam and a second colored light beam different from the first colored light beam; and
a shutoff valve in communication with the control unit for operatively being in communication with a hydraulic system of the hydraulic hammer;
wherein the control unit causes the laser generator to produce the first colored light beam when the leveling sensor indicates the hydraulic hammer is in a substantially vertical position and produce the second colored light beam when the leveling sensor indicates the hydraulic hammer is in a substantially non-vertical position, and
wherein the control unit causes the shutoff valve to move to an open position when the leveling sensor indicates the hydraulic hammer is in the substantially vertical position and move to a closed position when the leveling sensor indicates the hydraulic hammer is in the substantially non-vertical position.

US Pat. No. 10,189,152

SAFETY HAMMER FOR BREAKING GLASS, METHOD FOR ASSEMBLY OF A SAFETY HAMMER, SAFETY TOOL HOLDER, SYSTEM FOR HOLDING A SAFETY TOOL AND KIT OF PARTS

LIFE SAFETY PRODUCTS B.V....

1. A safety hammer for breaking glass, comprisinga housing comprising a first shell part and a second shell part, each of the shell parts having a substantially symmetrical exterior shape and configured to couple with each other;
a hammer head having at least one end for breaking the glass, wherein the hammer head is at least partly enclosed by the shell parts fastened to each other whereby at least one end of the hammer head extends outside the housing;
wherein the hammer head is configured to cooperate with the shell parts hereby fastening the shell parts to each other via the hammer head; and
wherein an inner surface of the first shell part is adapted with a first cooperating element and an inner surface of the second shell part is adapted with a second cooperating element, the first cooperating element and second cooperating element being configured to cooperate with the hammer head thereby fastening at least a portion of the shell parts to each other via the hammer head, the first cooperating element and the second cooperating element each being a ring of continuous material through which the hammer head is receivable,
wherein the hammer head comprises at least two head parts of which at least one head part is arranged for cooperation with at least one shell part, and
wherein the two hammer head parts are arranged for connection to each other through the first and second cooperation element with the shell parts for fastening the shell parts.

US Pat. No. 10,189,150

TORQUE LIMITING LOCKING CAP

DEPUY SYNTHES PRODUCTS, I...

1. A torque limiting driver system, comprising:a torque limiting driver including:
a handle including a torque limiting mechanism, where the handle includes a locking cap engagement protrusion;
a shaft with a cam portion including a cam mating feature; and
a locking cap including:
a mating recess including a plurality of scallops along the outer edge of the mating recess and wherein the plurality of scallops are configured to interface with the first mating feature;
a through-hole with through-hole mating feature configured to interface with the cam mating feature, wherein
the locking cap is configured to engage the torque limiting driver to lock the rotation of the shaft with respect to the handle;
the shaft includes a shaft recess; and
the locking cap includes a snap arm configured to engage the shaft recess such that the locking cap is fixed to the torque limiting driver.

US Pat. No. 10,189,148

ONE-WAY WRENCH SWITCHABLE BETWEEN TWO MODES

1. A one-way wrench comprising:a handle comprising:
a shank comprising a tunnel extending in a longitudinal direction thereof; and
a head formed at an end of the shank and made with a chamber in communication with the tunnel;
a toothed wheel rotationally inserted in the chamber of the head;
a detent pivotally connected to the head and elastically engaged with the toothed wheel so that the head rotates the toothed wheel in a one-way manner;
a rod movable in the tunnel of the shank in a reciprocated manner; and
a gear train arranged between the rod and the toothed wheel to convert the reciprocating of the rod to on-and-off rotation of the toothed wheel, wherein the gear train comprises:
a rack longitudinally connected to the rod and formed with ratchets and a transverse slot;
a pin connected to the rod and inserted in the transverse slot of the rack;
a first gear coaxially connected to the toothed wheel;
a last gear connected to the first gear and formed with ratchets engaged with the ratchets of the rack;
a spring for biasing the rack toward the last gear; and
a ball provided between the spring and the rack to reduce friction between the spring and the rack.

US Pat. No. 10,189,147

SOLID SURFACE CLAMP

Omni Cubed, Inc., Shingl...

1. A solid surface clamp, comprising:a top jaw constructed to exert a clamping force on a top clamping surface configured to contact a solid surface slab;
a bottom jaw comprising a bottom clamping surface;
a bolt attached to the bottom jaw and slideably received through the top jaw, the bolt comprising an alignment cutout and a threaded portion extending from the top jaw, wherein the bolt defines a bolt longitudinal axis;
a nut threaded onto the threaded portion, the nut and threaded portion constructed to transition the clamp from an open position to a clamping position;
the top jaw comprising an alignment shaft configured to contact the alignment cutout and maintain the top jaw and bottom jaw substantially fixed relative to each other about the bolt longitudinal axis; and
wherein the alignment cutout moves relative to the alignment shaft in the direction of the bolt longitudinal axis when the clamp transitions from an open position to a clamping position.

US Pat. No. 10,189,144

WATER-ABRASIVE-SUSPENSION CUTTING SYSTEM

1. A water-abrasive suspension cutting facility comprising:at least one high-pressure source, which high pressure source provides a carrier fluid at a high pressure;
at least one exit nozzle;
a high-pressure conduit connecting the at least one high-pressure source to the at least one exit nozzle;
an abrasive agent feed lock, which feed lock is connected to the high-pressure conduit and which feed lock comprises an entry-side shut-off element and an exit-side shut-off element and a lock chamber arranged between the entry-side shut-off element and the exit-side shut-off element; and
a suction device configured to be activated when the entry-side shut-off element is opened for producing a reduced pressure in the lock chamber, the suction device being connected to the lock chamber, wherein the lock chamber runs out via the exit-side shut-off element into a pressure container which is situated in the high-pressure conduit or a branch of the high-pressure conduit.

US Pat. No. 10,189,141

CHAMBER COMPONENTS WITH POLISHED INTERNAL APERTURES

APPLIED MATERIALS, INC., ...

1. A chamber component, comprising:a ceramic body; and
a plurality of polished apertures in the ceramic body, wherein a roughness of the plurality of polished apertures is less than 32 ?in,
wherein the ceramic body comprises a compound that includes a combination of Y2O3, ZrO2, Er2O3, Gd2O3, and SiO2, and
wherein the at least one aperture of the plurality of apertures is polished by flowing an abrasive media through the at least one aperture, wherein the abrasive media comprises a polymer base and a plurality of abrasive particles, and wherein a viscosity of the abrasive media is between about 150,000 cP and about 750,000 cP.

US Pat. No. 10,189,140

HAND-HELD MACHINE TOOL HAVING AN ELECTRONICALLY COMMUTATED ELECTRIC MOTOR AS DIRECT DRIVE

Robert Bosch GmbH, Stutt...

1. A hand-held machine tool, comprising:an electromotive drive; and
a machining tool having an outside diameter, wherein:
the electromotive drive has an electronically commutated electric motor and is configured to drive the machining tool, the electronically commutated electric motor having a rotation speed,
the electronically commutated electric motor has an outside diameter, and
a ratio of the outside diameter of the electronically commutated electric motor to a diameter of the machining tool is at most 0.42,
wherein a ratio of the rotation speed of the electronically commutated electric motor to the outside diameter of the machining tool is at most 28.5 rpm/mm.

US Pat. No. 10,189,138

SPECTACLE LENS MANUFACTURING SYSTEM, MANUFACTURING DEVICE, MANUFACTURING METHOD, MANUFACTURING INFORMATION MANAGEMENT SYSTEM, MANUFACTURING INFORMATION MANAGEMENT DEVICE, AND MANUFACTURING INFORMATION MANAGEMENT METHOD

HOYA CORPORATION, Tokyo ...

1. A spectacle lens manufacturing system in which a relationship between a type of a spectacle frame, framing content and framing performed at either (i) one of a plurality of client sides that request a manufacture of a spectacle lens or (ii) a manufacturing side of the spectacle lens is converted to a matrix, the matrix comprising a size correction value corresponding to each framing content, each frame type, and the client or manufacturing side that performs the framing, and the framing content being a framing process describing actions performed during framing, the system comprising:an information memory part configured to store the matrix including the size correction value for a scheduled edging shape of a lens to be edged as a numerical value in the matrix;
an edging information acquisition part configured to acquire edging information calculated based on (i) client side information for manufacturing a spectacle lens, including spectacle lens information, prescription value information, frame information that includes information regarding a frame type, and tracer information that includes information regarding a tracer type used for measuring a framed shape, (ii) spectacle lens manufacturing side information that includes edger information, and (iii) the size correction value selected from the matrix corresponding to the framing content, each frame type, and the client or manufacturing side that performs the framing, which is the size correction value for the scheduled edging shape of the lens to be edged, as numerical values in the matrix; and
an edger configured to edge the lens to be edged based on the edging information acquired by the edging information acquisition part in order to fit the lens into the frame and form the spectacle lens regardless of whether the client side or the manufacturing side performs the framing.

US Pat. No. 10,189,134

INDEXABLE PLENUM

GM GLOBAL TECHNOLOGY OPER...

1. A method, for using a plenum to collect debris during the cutting of an object, the plenum comprising a hollow body having a top end having a top opening and a bottom end having a bottom opening, a conduit situated between the top end and the bottom end, bifurcated from and in fluid communication with the hollow body, and a base plate having a machine side, a plenum side, and a base-plate opening, with the plenum side releasably engageable to the top opening, the method comprising:sealingly attaching the machine side of the base plate onto a stationary portion of a machine spindle nose of a machine;
engaging a cutter to the machine spindle nose wherein the cutter has a base portion and a cutter portion;
engaging the hollow body with the base plate to form an indexable plenum cutter assembly the base portion of the cutter is situated inside the hollow body, at least a portion of the cutter portion is situated outside the hollow body, and there are a body clearing between the hollow body and the cutter and a bottom clearing between the cutter and the bottom opening of the hollow body, and during operation of the machine spindle nose, the plenum does not form contact with the cutter and remains stationary;
cutting the object with the cutter while applying vacuum to the plenum through the conduit, wherein dust or debris generated during the cutting process enters the hollow body through the bottom clearing into the body clearing and into the conduit where it is vacuum removed;
detaching the hollow body from the base plate with the base plate remaining attached to the stationary portion of the machine spindle nose; and
replacing the cutter with another cutter.

US Pat. No. 10,189,133

MEASUREMENT, CALIBRATION AND COMPENSATION SYSTEM AND METHOD FOR MACHINE TOOL

NATIONAL CHUNG SHAN INSTI...

1. A measurement, calibration and compensation system for a machine tool, comprising:a first positioning base having a first XY plane and a first XZ plane, wherein the first positioning base is for mounting on a machine bed of the machine tool and located at a lateral side of an x-axis linear translation stage of the machine tool, the x-axis linear translation stage is mounted on the machine bed, and the first positioning base is made of a material selected from a group consisting of a zero-expansion glass material, an Invar material, and a granite material;
two first speckle image sensors for mounting on an object holding unit of the machine tool, wherein the object holding unit is translatable on the x-axis linear translation stage along the x-axis, the first speckle image sensors separately sense along the x-axis a speckle position of the object holding unit at the first XY plane and a speckle position of the object holding unit at the first XZ plane before and after the machine tool is started, and a difference between the speckle positions of the object holding unit at the first XY plane before and after the machine tool is started and a difference between the speckle positions of the object holding unit at the first XZ plane before and after the machine tool is started are used for calibrating and compensating a position of the object holding unit by an axis control system when the machine tool is machining;
a second positioning base having a second XY plane and a second YZ plane, wherein the second positioning base is provided for mounting on the machine bed of the machine tool and located at a lateral side of a y-axis linear translation stage and a z-axis linear translation stage of the machine tool, the y-axis linear translation stage is mounted on the machine bed, and the z-axis linear translation stage is translatable on the y-axis linear translation stage along the y-axis and the second positioning base is made of a material selected from the group consisting of a zero-expansion glass material, an Invar material, and a granite material; and
two second speckle image sensors, separately mounting on a cutter holding unit and the z-axis linear translation stage of the machine tool, wherein the cutter holding unit is translatable on the z-axis linear translation stage along the z-axis, one of the two second speckle image sensors senses a speckle position of the cutter holding unit along the y-axis at the second XY plane before and after the machine tool is started for machining, the other second speckle image sensor senses a speckle position of the cutter holding unit along the Z axis at the second YZ plane before and after the machine tool is started, and a difference between the speckle positions of the cutter holding unit at the second XY plane before and after the machine tool is started and a difference between the speckle positions of the cutter holding unit at the second YZ plane before and after the machine tool is started are used calibrating and compensating a position of the cutter holding unit by the axis control system when the machine tool is machining.

US Pat. No. 10,189,131

MOTOR CONTROL DEVICE FOR MACHINE TOOL HAVING PLURALITY OF AXES

FANUC CORPORATION, Yaman...

1. A motor control device for a machine tool equipped with a plurality of axes for machining a workpiece with a tool, the device comprising:a plurality of motor control units that respectively control motors respectively provided for driving the axes;
an abnormality detection unit provided for at least one of the motor control units and configured to output an abnormality detection signal upon detecting an abnormality with respect to the axis driven by the motor controlled by the motor control unit provided with the abnormality detection unit;
a safety operation control unit provided for a motor control unit that is not the motor control unit provided with the abnormality detection unit, the safety operation control unit configured to, upon receiving the abnormality detection signal, control the motor that drives the axis provided with the tool in such a way that the tool comes out of contact with the workpiece; and
a communication unit for communication between the motor control units that transmits the abnormality detection signal outputted by the abnormality detection unit to the safety operation control unit.

US Pat. No. 10,189,130

MACHINE TOOL

DMG MORI CO., LTD., Yama...

1. A machine tool having a tool changer, comprising:a tool holding part holding a plurality of tools; and
a tool change mechanism changing a tool held by the tool holding part and a tool clamped by a spindle,
wherein the tool holding part is positioned in a side of the spindle to hold the plurality of tools in a manner in which axes of the tools are parallel to an axis of the spindle,
the tool change mechanism includes a circular arc movement mechanism,
the circular arc movement mechanism moves the tools from a tool holding position to a tool change position at which the tool is coaxial with the axis of the spindle, by at least a circular arc movement on a plane on which the axis of the spindle positioned in the tool change position and an axis of the tool positioned in the tool holding part are arranged,
the tool position is different for each of the tools,
a dividing wall is formed between the tool change mechanism and the spindle,
the dividing wall includes an opening which is closed by a shutter, and
the circular arc movement mechanism moves the tools in the circular arc movement through the opening when the shutter opens the opening.

US Pat. No. 10,189,129

TOOL REPLACEMENT APPARATUS

FANUC CORPORATION, Yaman...

1. A tool replacement apparatus for a machine tool comprising:a turning tool magazine capable of attaching or removing a tool to/from a spindle of a machine tool;
a tool replacement control unit which controls operations of turning the tool magazine and attaching or removing a tool to/from a spindle; and
a setting unit which sets a rotatable range of the tool magazine,
the tool replacement control unit including:
a determining unit which determines whether or not a designated rotation angle in an instruction for turning a tool magazine is within the rotatable range set by the setting unit; and
a unit which stops an operation of replacing a tool when the determining unit determines that a designated rotation angle is out of a rotatable range.

US Pat. No. 10,189,128

TOOL MAGAZINE FOR A MANIPULATOR

1. A bending cell comprising:a bending machine,
a manipulator,
a bending tool magazine,
a first protection device,
a second protection device, and
a control device for safety, the control device being operatively coupled to the first protection device and to the second protection device, wherein
the manipulator is configured at least for handling a workpiece and for performing bending tool exchange,
the manipulator is configured for removing bending tools from the bending tool magazine and for inserting the bending tools into the bending machine,
the bending tool magazine comprises a plurality of bending tool holding fixtures arranged distributed in a preparation area,
the bending tool magazine further comprises a first side facing the manipulator, a first access opening in the first side, a second side opposite to the first side and facing away from the manipulator and away from the bending machine, and a second access opening in the second side,
the manipulator is positioned to remove the bending tools from the bending tool magazine via the first access opening in the first side of the bending tool magazine,
the manipulator is operable within the workspace, which is determined by an extension of the manipulator, between the bending tool holding fixtures arranged in the preparation area and the bending machine,
the workspace comprises a first part comprising more than fifty percent of the workspace, said first part of the workspace comprising the bending machine,
the first access opening is assigned the first protection device for separating the preparation area from the first part of the workspace of the manipulator, and the second access opening is assigned the second protection device for separating the preparation area from an area occupied by an operator, and via the control device, the first and the second protection devices are activated and deactivated alternately,
such that only one of the first access opening and the second access opening is open at each time to allow access into the tool magazine, and in order to provide access through the first access opening, the first protection device is moved vertically in a first direction with respect to said first access opening, and in order to provide access through the second access opening, the second protection device is moved vertically in a second direction, which is opposite to the first direction, with respect to said second access opening, and
such that when the preparation area is separated from the first part of the workspace by the first protection device, the first part of the workspace is available for:
movements of the manipulator,
supplying the workpiece to the bending machine,
guiding the workpiece during a bending process, and
removing the workpiece from the bending machine after the workpiece has been bent by a bending tool.

US Pat. No. 10,189,124

ASSEMBLING DEVICE OF WHEEL HUB UNIT

NSK Ltd., Tokyo (JP)

1. An assembling device of a wheel hub unit, comprising:a bearing setting unit configured to set a bearing unit including an inner ring, an outer ring, a plurality of tapered rollers rollably arranged between an inner ring raceway formed on an outer peripheral surface of the inner ring and an outer ring raceway formed on an inner peripheral surface of the outer ring, and a stepped part which is formed on an outer end part of the inner ring in an axial direction and with which end surfaces of the tapered rollers in the axial direction are in contact, such that the bearing unit is coaxial with respect to a hub cylindrical part provided at an end part of a hub main body in the axial direction and can be moved toward the hub cylindrical part;
a rotational drive source configured to transmit rotational force around an axis to the bearing unit set in the bearing setting unit; and
an inner-ring press-fitting unit configured to externally fit the inner ring of the bearing unit to which the rotational force around the axis has been transmitted, to the hub cylindrical part; wherein
the bearing setting unit includes:
a circular holding part configured to hold the outer ring of the bearing unit from an outer periphery;
a circular driven member which is arranged coaxially around the hub main body and to which the rotational force is transmitted from the rotational drive source; and
a rotational force-transmitting part which is connected between the driven member and the holding part and configured to transmit the rotational force, transmitted to the driven member, to the holding part; and
the holding part includes a plurality of divided holding members being spaced apart from one another in an opening state and holding the outer ring of the bearing unit from the outer periphery in a closed state.

US Pat. No. 10,189,122

TORCH GUIDE DEVICE

1. A clamp assembly comprising:a clamp body made of a magnetically attractive material, wherein the clamp body comprises a shell defining a cavity and a first face of the clamp body is configured to rest on a first surface for clamping the clamp body to the first surface;
a first shaft member extending along a first longitudinal axis through the shell and into the cavity toward the first face;
a magnetic member mounted on the first face of the clamp body, the magnetic member mounted to move along at least a portion of the first shaft member in at least the direction of the first longitudinal axis;
wherein movement of the magnetic member is constrained between a first stop and a second stop, the first stop and the second stop positioned on opposite sides of the magnetic member along the first shaft member; and
wherein the first shaft member is moveable in the direction of the first longitudinal axis relative to the clamp body to retract or insert at least a portion of the first shaft member from the or into the shell, and wherein movement of the first shaft member displaces the magnetic member with the first shaft member within the cavity.

US Pat. No. 10,189,121

ORGANIC ACID-OR LATENT ORGANIC ACID-FUNCTIONALIZED POLYMER-COATED METAL POWDERS FOR SOLDER PASTES

1. Solder particles having a polyalkylene polymer with latent organic acid functional groups coated on at least a portion of the surface thereof, wherein the solder particles are made from an alloy selected from the group consisting of tin/silver/copper, tin/zinc, tin/bismuth, tin/lead, and tin/indium/bismuth and wherein the solder particles have a varied size distribution of diameters of about 0.5 to about 100 um, wherein the polyalkylene is selected from the group consisting of polyethylene, polypropylene, polybutylene and mixtures thereof and wherein the latent organic acid functional group is an anhydride.

US Pat. No. 10,189,118

METHOD AND APPARATUS FOR EVALUATING AN ULTRASONIC WELD JUNCTION

GM Global Technology Oper...

1. A method for evaluating a battery cell composed of a cell body having a plurality of electrode foils joined to a positive terminal and a negative terminal, wherein the positive terminal and the negative terminal are each joined to the electrode foils at weld junctions, the method comprising:retaining the cell body of the battery cell in a first clamping device;
gripping one of the positive and negative terminals in a terminal gripper;
applying, employing a dynamic stress end effector coupled to the terminal gripper, a vibrational excitation load to the one of the positive and negative terminals;
monitoring, via a controller, impedance between the positive terminal and the negative terminal; and
evaluating integrity of the weld junction of the one of the positive and negative terminals based upon the impedance.

US Pat. No. 10,189,117

ADHESION IMPROVEMENT VIA MATERIAL NANOSTRUCTURING OR TEXTURIZING

The United States of Amer...

1. A method of treating a material surface comprising:selecting a material of interest to be processed comprising a target surface of interest;
determining a surface adhesion transformation of said target surface of interest based on said material's properties, a shape of said target surface of interest, an adhesion material, and required degree of adhesion between said target surface of interest and another object's surface, wherein said material's properties comprise mechanical or chemical interfacial material properties required after application of said method;
providing an at least one ultra-short pulse laser system (USPL), a rastering system adapted for controlling rastering of laser energy output of said USPL over said target surface of interest based on said determined surface adhesion transformation of said target surface of interest, and an environmental system to control environmental conditions around said target surface of interest comprising one or more target adhered surfaces to be modified, wherein said surface adhesion transformation comprises a transformation of said target surface of interest to a first depth resulting in an increase of porosity or texture of said target surface of interest which alters chemical bonding properties and adhesion properties of the target surface of interest;
configuring said USPL by adapting said laser energy output so said USPL is operable to convert a portion of said target surface of interest's material up to a second depth into a plasma state during application of said laser energy output, said configuring of said USPL by programming said USPL comprises a configuration so said USPL is operable to a pre-determined irradiance, pulse duration of femtoseconds (fs) to restructure said target surface of interest, and pulse frequency, laser wavelength, and laser polarization based on said determined surface adhesion transformation so said USPL is operable to create nano-structures on said target surface of interest during application of said laser energy output to produce a resultant processed region having a surface covered by pre-determined nano structure formations which alter the resultant processed region to increase surface area and thereby increase adhesion properties of said surface of the processed region;
configuring said system adapted for rastering said laser energy output over said target surface of interest to apply said laser energy output in a pre-determined rasterization pattern and laser angle to said target surface of interest during application of said laser energy output; and
applying said laser energy output based on said programming, said determined surface level of adhesion, and said adapting of said laser energy output thereby exposing said target surface of interest wherein a laser beam of said USPL is rastered across said target surface of interest, adjusting one or more positions of said laser beam relative to said target surface of interest by a width of a functional beam diameter of said laser beam with each pass of the USPL.

US Pat. No. 10,189,116

LASER MACHINING HEAD

PANASONIC INTELLECTUAL PR...

1. A laser machining head comprising:a collimation lens for making a laser beam parallel;
a focusing lens for condensing the paralleled laser beam; and
a nozzle unit through which the condensed laser beam is transmitted, the nozzle unit including:
a protective member for transmitting the laser beam;
an inner nozzle through which the laser beam transmitted through the protective member passes;
an outer nozzle disposed outside the inner nozzle;
a nozzle holding section for holding the inner nozzle and the outer nozzle; and
an orifice, having a ring shape surrounding a hollow space, in contact with the inner nozzle and interposed between the nozzle holding section and the outer nozzle,
wherein the nozzle holding section has a first gas path connecting an air supply port disposed in the nozzle holding section and the orifice,
the inner nozzle and the outer nozzle forms a second gas path between the inner nozzle and the outer nozzle,
the orifice has a third gas path for connecting the second gas path to the first gas path,
the orifice has an inner side face facing the hollow space, an outer side face opposite to the inner side face, and a bottom face connected to the inner side face and the outer side face,
a plurality of the third gas paths is disposed in the orifice at regular intervals,
the orifice has a plurality of through-holes therein connecting the outer side face to the bottom face,
each of the plurality of through-holes constitutes a respective one of the third gas paths,
the outer side face has a top portion, a bottom portion, and a recessed portion between the top portion and the bottom portion,
the recessed portion extends along an entire circumference of the outer side face,
the each of the plurality of through-holes connects the recessed portion and the bottom face, and
in a vicinity of a tip of the nozzle unit, an opening connected to the second gas path is disposed.

US Pat. No. 10,189,115

LASER PROCESSING APPARATUS AND LASER PROCESSING METHOD

MITSUBISHI HEAVY INDUSTRI...

1. A laser processing apparatus for processing a workpiece using laser light, comprising:a first optical system that includes a first prism and a second prism and receives the laser light output from a laser light source;
a second optical system that includes a third prism and a fourth prism and receives the laser light from the first optical system;
a condensing optical system that receives the laser light from the second optical system and condenses the laser light to guide the condensed laser light to the workpiece;
a first driving device that rotates the first prism and rotates the second prism synchronously with the first prism;
a second driving device that rotates the third prism and rotates the fourth prism synchronously with the third prism; and
a controller that controls the first driving device and the second driving device such that the workpiece is irradiated with the laser light while the laser light turns around an optical axis of the condensing optical system, wherein
the controller adjusts irradiation conditions of the laser light including an incidence position and an incidence angle of the laser light with respect to the workpiece, by rotating the first prism and the third prism together in a state of fixing a relative position between the first prism and the third prism in the rotational direction, and adjusting a relative position of the second prism with respect to the first prism and a relative position of the fourth prism with respect to the third prism in the rotational direction.

US Pat. No. 10,189,114

ELECTRON BEAM LAYER MANUFACTURING

SCIAKY, INC., Chicago, I...

1. An apparatus for layer manufacturing a metallic three-dimensional work piece, comprising:a) a housing defining a chamber capable of evacuation and within which the metallic three-dimensional work piece is formed layer by layer from a plurality of successively deposited molten pool deposits, the housing enclosing:
A. a plurality of wires fed from one or more material delivery devices;
B. an electron beam gun that melts the plurality of wires;
C. a table upon which the metallic three-dimensional work piece is formed, the table and the electron beam gun being adjustably spaced relative to each other so that as the metallic three-dimensional work piece is formed layer by layer from the plurality of successively deposited molten pool deposits, the spacing incrementally increases;
D. an optical assembly including:
i. a first enclosure,
ii. optics housed in the first enclosure,
iii. an aperture in a wall of the first enclosure for allowing access, into the first enclosure, of light emitted by the plurality of successively deposited molten pool deposits so that the light reaches the optics, and
iv. a vapor protection device that substantially avoids build-up of metal vapor on the optics during operating of the apparatus;
E. an imaging device including:
i. a detector array,
ii. thermally regulated electronic componentry, and
iii. a second enclosure that substantially encloses the detector array and the thermally regulated electronic componentry, and also includes an opening through which light that is emitted by the plurality of successively deposited molten pool deposits can communicate with the detector array; and
F. a frame that carries the enclosures of the optical assembly and the imaging device in spaced apart relation from each other so that the aperture of first enclosure is substantially overhead of the plurality of successively deposited molten pool deposits, and the first and second enclosures are separated from each other;
b) a closed loop control device configured to automatically adjust one or more processing parameters of the apparatus in response to data obtained from the imaging device.

US Pat. No. 10,189,113

RESISTANCE SPOT WELDING METHOD

GM Global Technology Oper...

20. The resistance spot welding method of claim 11, wherein applying electrical energy to the first and second electrically conductive pins includes supplying sufficient electric current to the electrically conductive coating for a sufficient amount of time in order to completely melt the electrically conductive coating.

US Pat. No. 10,189,112

WELDING EQUIPMENT FOR METALLIC MATERIALS AND METHOD FOR WELDING METALLIC MATERIALS

NETUREN CO., LTD., Tokyo...

1. A method for spot-welding metallic materials by sandwiching the metallic materials with respective tips of a pair of electrodes opposing to each other and energizing the metallic materials, wherein:a spot-welding power source is connected to the pair of electrodes for supplying a spot-welding power to the pair of electrodes to heat and spot-weld a prescribed region of the metallic materials sandwiched by the tips of the pair of electrodes, the spot-welding power being either AC electric power having a first frequency or DC electric power, and
a high-frequency power source is connected to the pair of electrodes for supplying AC electric power having a second frequency to the pair of electrodes to heat a region of the metallic materials different from the prescribed region,
the method comprising:
a first step for heating and spot-welding the prescribed region of the metallic materials sandwiched by the tips of the pair of electrodes by a first energization applying, via said spot-welding power source, the AC electric power having the first frequency or the DC electric power to the pair of electrodes; and
a second step for heating said region different from the prescribed region in the first step by a second energization applying, via the high-frequency power source, the AC electric power having the second frequency to the pair of electrodes that are maintained at the same position as in the first step,
wherein the spot-welding power source and the high-frequency power source are respectively connected to the pair of electrodes in parallel,
wherein the first frequency is lower than the second frequency, and
wherein the heating time in the first step and that in the second step are independently controlled.

US Pat. No. 10,189,111

INDIRECT SPOT WELDING METHOD

JFE Steel Corporation, T...

1. An indirect spot welding method for welding members including at least two overlapping steel sheets that have a ferrite phase as a main phase by holding a welding electrode against a steel sheet from one side while applying pressure with the welding electrode, attaching a feeding point to a steel sheet at a location remote from the welding electrode, and allowing current to flow between the welding electrode and the feeding point, the method comprising:contacting a magnetic rigid body to the one side of the steel sheet in a peripheral area of the welding electrode;
securing an overlapping region in the peripheral area of the welding electrode by a magnetic force produced by the rigid body; and
welding the at least two overlapping steel sheets.

US Pat. No. 10,189,110

PLASMA CUTTING METHOD AND PLASMA CUTTING DEVICE

KOMATSU INDUSTRIES CORPOR...

6. A plasma cutting device configured to cut out a plurality of cutout members from a plate blank, comprising:a mount table onto which the plate blank to be cut is mounted;
a plasma torch configured to generate a plasma arc and movable relative t the F fount table in, a horizontal direction and in an up-and-down direction; and
a controller programmed to control movement of the plasma torch relative to the mount table and generation of the plasma arc from the plasma torch, wherein
the controller is programmed to
receive a set data regarding a processing line;
form an aperture on an outer peripheral side of a given one of the cutout members by maintaining the plasma torch at a first height from the plate blank on the outer peripheral side or the given cutout member while the plasma arc is, being generated from the plasma torch and by moving the plasma torch relative to the plate blank by a predetermined distance in the horizontal direction; and
form a continuous cutting groove along an outer contour of the given cutout member by setting the plasma torch at a second height lower than the first height and by moving the plasma torch in the horizontal direction along an incision part and the processing line continuing to the incision part,
the controller being further programmed to set the plasma torch at a position lower than the first height when the plasma arc begins to be generated, and to then move the plasma torch in the horizontal direction and simultaneously in an upward direction to the first height.

US Pat. No. 10,189,109

PURGE DAM AND METHOD OF USE

DOCKWEILER AG, Neustadt-...

1. A purge dam assembly for confining a volume within an assembly of pipes, including a distal pipe and a proximal pipe together arranged for butt welding at a seam, comprises:a distal disk, the distal disk being covered at its periphery with a distal sock, the sock being a tubular pipe comprising a gasketing material, the gasketing material consisting of a synthetic textile, the synthetic textile comprising 100% continuous filament polyester, the filament being sufficiently soft to contact an electropolished stainless steel surface without significantly scratching that surface, the distal disk being sized such that the distal sock contacts but does not completely seal against an inner surface of the distal pipe permitting a purging flow of purge gas from the volume and past the distal disk when the purge disk assembly is inserted into the assembly of tubes or pipes;
a proximal disk, the proximal disk being covered at its periphery with a proximal sock comprising the gasketing material, the proximal disk defining a purge gas portal for admitting of a purging flow of purge gas into the volume and, further, being sized such that the proximal sock contacts but does not completely seal against an inner surface of the proximal pipe permitting a purging flow of purge gas from the volume and past the distal disk; and
a cross-member having a proximal and a distal end, the proximal end being affixed to the proximal disk and the distal end being affixed to the distal disk in a manner to preserve the spatial separation between the proximal disk and distal disk and to maintain the proximal and distal disks in coaxial alignment.

US Pat. No. 10,189,108

HOT-WIRE WELDING ASSEMBLY FOR DEEP AND NARROW RECESSED GAPS

Lincoln Global, Inc., Ci...

1. A contact tip assembly, comprising:a contact tip comprising,
a body portion having a first end to operably connect to a welding torch, and a second end that is opposite the first end along an axis running through the body portion,
a cavity in the body portion extending from the second end into the body portion, and
a channel passing through the body portion along the axis from the first end to the cavity for passage of a wire; and
a non-electrically conductive extension tube inserted into said cavity and coupled to said contact tip,
wherein said non-electrically conductive extension tube has a channel which aligns with said channel of said body portion when said extension tube is inserted into said cavity.