US Pat. No. 10,191,103

METHOD OF LOCATING A SOURCE OF TRANSIENT SIGNALS IN A DISPERSIVE ENVIRONMENT

INSTITUT POLYTECHIQUE DE ...

1. A method of locating in a dispersive environment a source of pulses with at least a pair of sensors, the method comprising the steps of:positioning a pair of sensors in the dispersive environment, the pair of sensors being located at a predetermined distance L to each other;
detecting a pulse at the level of each sensor originating from the source;
constructing a phase diagram for each of said pulses from N vectors having their coordinates corresponding to the amplitude of the pulse at a sampling time ti and at next successive sampling times; and
calculating the ratio for each pair of sensors between distances L1 and L2 from each sensor to the source with formula:
whereare the norms of vectorsof the phase diagrams corresponding to the pulses detected by the sensors so that the source is located by the phase diagrams without synchronization of the sensors;wherein the calculated location of the source is communicated to specify the location of a maintenance operation.

US Pat. No. 10,191,102

AUTOMATIC CURRENT TRANSFORMER POLARITY CORRECTION

UTILITY RELAY COMPANY, C...

1. A method of processing current transformer data, comprising the steps of:obtaining, by an electronic protection controller for a circuit breaker, first current data based on a first current signal from a first current transformer on a first phase of a three-phase electrical circuit protected by the circuit breaker;
obtaining, by the electronic protection controller, second current data based on a second current signal from a second current transformer on a second phase of the three-phase electrical circuit;
obtaining, by the electronic protection controller, third current data based on a third current signal from a third current transformer on a third phase of the three-phase electrical circuit;
determining, using at least the first current data, the second current data, and the third current data, whether one of the first current transformer, the second current transformer, and the third current transformer is an improper polarity phase current transformer that is connected to the electronic protection controller with an improper polarity by determining whether a magnitude of a vector sum of a first phase current on the first phase of the three-phase electrical circuit, a second phase current on the second phase of the three-phase electrical circuit, and a third phase current on the third phase of the three-phase electrical circuit is greater than each individual magnitude of the first phase current, the second phase current, and the third phase current;
upon determining that said one of the first current transformer, the second current transformer, and the third current transformer is an improper polarity phase current transformer that is connected to the electronic protection controller with an improper polarity, automatically inverting, by the electronic protection controller, obtained current data corresponding to the improper polarity phase current transformer;
performing a ground fault calculation using automatically inverted current data corresponding to the improper polarity phase current transformer;
generating a trip command, by a trip signal output, upon detection of the ground fault, and
providing the trip command to a circuit breaker actuator.

US Pat. No. 10,191,080

DRONE INCLUDING ADVANCE MEANS FOR COMPENSATING THE BIAS OF THE INERTIAL UNIT AS A FUNCTION OF THE TEMPERATURE

Parrot Drones, Paris (FR...

1. A drone, comprising a main circuit board (24) on which are mounted electronic components as well as an inertial unit, IMU, (26) comprising gyrometer sensors for measuring the instantaneous rotations of the drone in an absolute reference system, and/or accelerometer sensors for measuring accelerations of the drone in this reference system, the IMU (26) including an internal temperature sensor (34) delivering a chip temperature signal (?°chip),characterized in that it comprises:
a heating component (28) mounted on the circuit board (24) near the IMU (26);
a thermal guide (30) incorporated to the circuit board (24), this thermal guide extending between the heating component (28) and the IMU (26) so as to allow a transfer (32) to the IMU of the heat produced by the heating component; and
a thermal regulation circuit (44-62), receiving as an input the chip temperature signal (?°chip) and a predetermined set-point temperature signal (?°ref), and outputting a heating component piloting signal (TH_PWM), so as to control the heat supply to the IMU as a function of the difference between chip temperature and set-point temperature.

US Pat. No. 10,191,063

BRUCELLOSIS, Q-FEVER, AND LYME DISEASE BIOMARKERS AND USES THEREOF

Caprion Proteomics Inc., ...

1. A method for detecting HISTH4, LDHB, and MDH1 in a subject,obtaining a fluid sample(s) from a subject suspected of having Brucellosis,
detecting whether HISTH4, LDHB, and MDH1 are present in the fluid sample(s) by ionizing the fluid sample(s) and detecting charged particles corresponding to HISTH4, LDHB, and MDH1;
thereby detecting HISTH4, LDHB, and MDH1 in a subject suspected of having Brucellosis.

US Pat. No. 10,191,052

METHODS OF DIAGNOSING AND TREATING ACTIVE TUBERCULOSIS IN AN INDIVIDUAL

ProteinLogic Limited, Ca...

1. A method of treating active (smear positive) tuberculosis in an individual, wherein the method comprises:(a) differentially diagnosing active (smear positive) tuberculosis over latent tuberculosis in the individual, comprising:
(1) obtaining a test biological sample from an individual;
(2) quantifying the amount of three or more biomarkers selected from CD14, CD22, CD25, CD64, IL-10, CXCL10, and IFN gamma, wherein at least one of the biomarkers is IFN gamma and at least one of the biomarkers is IL-10; and
(3) comparing the amounts of the biomarkers in the test biological sample with the amounts present in one or more control samples, such that a difference in the level of the biomarkers in the test biological sample is indicative of a differential diagnosis of active (smear positive) tuberculosis over latent tuberculosis; followed by
(b) administering an anti-tuberculosis medicament to the individual if there is a positive diagnosis for active (smear positive) tuberculosis.

US Pat. No. 10,190,965

CELL CAPTURE SYSTEM AND METHOD OF USE

Celsee Diagnostics, Inc.,...

1. A system for isolating and analyzing a set of particles from a biological sample, comprising:a substrate defining a set of chambers defined at a broad surface, wherein each chamber in the set of chambers is configured to retain a single particle of the set of particles and comprises:
a set of walls defining a chamber volume, a chamber length, and a chamber cross-section;
an open surface permitting access of the single particle to the chamber volume from a direction perpendicular to the broad surface of the substrate; and
wherein each chamber of the set of chambers is fluidly isolated from an adjacent chamber by the set of walls of each chamber, and wherein fluid received at the inlet channel enters each chamber only by way of the open surface of each chamber;
an inlet channel positioned superior the set of chambers and directly fluidly coupled to the set of chambers, whereby fluid received at the inlet channel concurrently accesses each of the chambers in the set of chambers at the open surface of each chamber; and
a fluid delivery module fluidly coupled to the inlet channel operable and configured to distribute a reagent fluid in a direction substantially parallel to the broad surface through the inlet channel, permitting access of the reagent fluid to the set of chambers.

US Pat. No. 10,190,945

PARTICULATE MATTER/NUMBER SYNCHRONIZATION MEASUREMENT DEVICE

3DATX Corporation, Buffa...

1. An emissions measurement system comprising:an emissions sample inlet;
at least three sensors connected to the emissions sample inlet, wherein the sensors are sequentially connected in a linear arrangement and wherein each of the at least three sensors is configured to perform a different measurement of a sample;
an emissions sample outlet connected to the at least three sensors;
a sensor cartridge defining the emissions sample inlet and the emissions sample outlet, wherein the sensors are disposed within the sensor cartridge between the emissions sample inlet and emissions sample outlet;
a sample probe that is fluidically connected to the emissions sample inlet; and
a battery disposed in the sensor cartridge that is configured to provide power to the sensors.

US Pat. No. 10,190,940

SPECTRALLY EFFICIENT OPTICAL FREQUENCY-DOMAIN REFLECTOMETRY USING I/Q DETECTION

DSIT Solutions Ltd., Giv...

1. A system for fiber-optic reflectometry, the system comprising:an optical source, which is configured to generate an optical interrogation signal that is transmitted into an optical fiber;
a beat detection module, which is configured to receive from the optical fiber an optical backscattering signal in response to the optical interrogation signal, and to mix the optical backscattering signal with a reference replica of the optical interrogation signal using In-phase/Quadrature (I/Q) mixing, so as to produce a complex beat signal having In-phase (I) and Quadrature (Q) components; and
a processor, which is configured to sense one or more events affecting the optical fiber by analyzing the I and Q components of the complex beat signal, including defining in the complex beat signal at least:
a first time interval, during which an instantaneous frequency of the optical backscattering signal is guaranteed to be lower than the instantaneous frequency of the reference replica; and
a second time interval, during which the instantaneous frequency of the optical backscattering signal is guaranteed to be higher than the instantaneous frequency of the reference replica.

US Pat. No. 10,190,909

PATH DETECTION SYSTEM BASED ON SOLAR BLIND ULTRAVIOLET LIGHT SIGNALS

NANJING UNIVERSITY 5D TEC...

1. A path detection system based on solar blind ultraviolet light signals, comprising a SBUV light signal emitter, a SBUV detector and a signal processing module, wherein the SBUV light signal emitter is arranged on a road to serve as a path mark line; the SBUV detector is configured to detect the path mark line and transmit the detected signals from the SBUV light signal emitter to the signal processing module; and the signal processing module acquires a travelling path in real time by using a path line extraction algorithm, and outputs path information.

US Pat. No. 10,190,875

PATTERN MEASUREMENT CONDITION SETTING DEVICE AND PATTERN MEASURING DEVICE

Hitachi High-Technologies...

1. A pattern measurement condition setting device which sets a pattern measurement condition when measurement of a pattern is executed based on electron detection obtained by emitting a charged particle beam to a sample, the device comprising:an arithmetic unit which selects a pattern having a predetermined condition from pattern information for each of a plurality of exposure conditions obtained when an exposure condition of a reduced projection exposure device is changed, or pattern information for each of a plurality of exposure conditions obtained when a simulated exposure condition is changed, the arithmetic unit selecting said pattern as an object to be measured or a candidate for the object to be measured, the change of the size or shape of the pattern with respect to a change of the exposure condition satisfying the predetermined condition, and a number of said patterns having a same shape as that of the pattern satisfying the predetermined condition,
wherein the arithmetic unit narrows down the number of the plurality of patterns having the same pattern shape by reducing a size of an instrumentation region and ordering the plurality of patterns based on design data, and calculates the size of change of the pattern shape with respect to the change of an exposure condition parameter by using a result based on the narrowed-down pattern shape or information on the pattern shape formed by changing the exposure condition,
wherein the predetermined condition is based on an exposure condition parameter sensitivity and the number of the plurality of patterns having the same shape, and
wherein the exposure condition parameter sensitivity is determined by calculating a variation of a pattern shape change amount with respect to a change in the size of the instrumentation region and a change in said exposure condition parameter.

US Pat. No. 10,190,844

SIGHT ADJUSTMENT DEVICE IN SIMULATION GUN

TOKYO MARUI CO., LTD., T...

1. A sight adjustment device, which adjusts a shooting course of a bullet loaded in a cartridge portion of each of a plurality of barrels of a simulation gun, and the sight adjustment device comprising:an operation unit,
a link member and
a plurality of pressurization members;wherein the operation unit is provided on a main body of the gun and the operation unit adjusts a backspin amount for the bullet,wherein one end portion of the link member is disposed on the operation unit, the other end portion of the link member is disposed on at least one of the plurality of pressurization members, and the link member transmits the backspin amount to the plurality of pressurization members, andwherein each of the plurality of pressurization members is provided in each of cartridge portions of the plurality of barrels and adds pressure corresponding to the backspin amount to the bullet in each of cartridge portions of the plurality of barrels, thereby applying a rotational motion to the bullet at the time of shooting.

US Pat. No. 10,190,836

LOADER

Ulbrich Schroeder Design ...

1. A firearm system comprising:a rifle having a butt, a muzzle, a receiver disposed between the butt and the muzzle, a magazine fixed to the rifle between the butt and the muzzle, wherein the magazine is in communication with the receiver, an ejection port in communication with the receiver; and
a loading device comprising a housing having a channel, a plunger slideably disposed within the channel, and a spout extending away from the housing, wherein the plunger includes an articulating arm extending away from one end of the plunger, wherein the arm has a first and a second opposing end, and wherein the arm includes a first plug disposed about the first end of the arm and a second plug disposed about the second end of the arm.

US Pat. No. 10,190,822

STAGED REACTION PLENUM PARTITION WALL FOR FURNACE

Blasch Precision Ceramics...

20. A method for controlling distribution of secondary flow in a high temperature reaction furnace, said method comprising the steps of:providing a plenum assembly comprising
a plurality of refractory brick members, each refractory brick member comprising a substantially tubular body having a first end, a second end opposed to said first end along a longitudinal length of said refractory brick member, a central bore extending from said first end to said second end along said longitudinal length thereof and defining an inner surface of said refractory brick member, and an outer surface extending from said first end to said second end along said longitudinal length thereof, wherein said outer surface of each said refractory brick member has a shape that transitions axially between a plurality of hexagonally-shaped portions and a plurality of non-hexagonally-shaped portions along the longitudinal length thereof, and wherein said plurality of refractory brick members are arranged and interlocked with one another in a vertical and horizontal manner via mating members provided on said hexagonally-shaped portions of said outer surfaces thereof, anda continuous plenum space defined by said non-hexagonally-shaped portions of said outer surfaces of said refractory brick members, wherein each said refractory brick member comprises at least one opening provided in a portion of said outer surface of said refractory brick members and in fluid communication with said plenum and at least one of an end face of said refractory brick members and said central bore of said refractory brick members; andinjecting secondary air directly into said plenum space of said plenum assembly via one or more injection ports provided in communication with said plenum space.

US Pat. No. 10,190,818

CONTAINER SPINNING DEVICE AND METHOD OF USE THEREOF

Spin Chill Corp., Gaines...

1. An apparatus used for accelerating heat transfer between a container and a surrounding medium accomplished by holding and rotating a container, the apparatus comprising:a first cylindrical sleeve having two ends, a first end being a closed end and a second end being an open end, said open end having an initial diameter less than the diameter of the cylindrical sleeve forming a can clip for engaging one end of the container;
a second cylindrical sleeve extending from said inner surface of said first cylindrical sleeve, said second cylindrical sleeve having an inner diameter less than the diameter of the first cylindrical sleeve, said second cylindrical sleeve having two ends, a first end being a closed end which extends from the inner surface of the closed end of said first cylindrical sleeve and a second open end, said second open end forming a bottle clip for engaging a portion of a neck of a bottle; and
a shaft centrally mounted to said first and second cylindrical sleeves, said shaft having two ends, a first end connected to said first and second cylindrical sleeves and a second end adapted to be connected to a rotating device.

US Pat. No. 10,190,803

SYSTEM AND METHOD FOR CLEANING SURFACES

Dynamis Solutions, LLC, ...

1. A heliostat comprising:a heliostat mirror surface;
a heliostat cleaning mechanism in cleaning contact with the heliostat mirror surface; and
a heliostat drive system that moves the heliostat mirror surface relative to the cleaning mechanism, removing material from the heliostat mirror surface,
wherein the heliostat cleaning mechanism includes a flexible blade having a longitudinally extending edge in cleaning contact with the mirror surface; and
a blade cleaning device, extending longitudinally in a fixed position along an edge of the heliostat mirror surface, that cleans the heliostat cleaning mechanism.

US Pat. No. 10,190,795

AIR CONDITIONER DIAGNOSTIC SYSTEM, AIR CONDITIONER AND MOBILE COMMUNICATION TERMINAL

Hitachi-Johnson Controls ...

9. An air conditioner diagnostic system of an air conditioner having an outdoor unit and an indoor unit, wherein:the air conditioner includes a control board disposed in the outdoor unit or the indoor unit, and the control board includes a wireless communication unit configured to wirelessly transmit operation data indicating an operation state of the air conditioner and model data by light emission to a mobile communication terminal,
the wireless communication unit is further configured to wirelessly transmit the operation data and the model data of the air conditioner by light emission only in response to a reception request from the mobile communication terminal,
the mobile communication terminal is configured to receive the light emission from the wireless communication unit via a camera function,
the mobile communication terminal is further configured to communicate with a maintenance server system installed in a remote location, which stores a diagnostic program corresponding to each model of the air conditioner; and
based on the model data and the operation data received by the mobile communication terminal, the maintenance server system or the mobile communication terminal is configured to diagnose the air conditioner using the diagnostic program corresponding to the model data, and the mobile communication terminal is configured to display a diagnostic result of the diagnostic program on a display unit of the mobile communication terminal.

US Pat. No. 10,190,794

SYSTEM AND APPARATUS FOR WIRELESS ENVIRONMENTAL ZONE CONTROL

ARZEL ZONING TECHNOLOGY, ...

1. A control system to wirelessly control environmental parameters of a predefined zone in a forced air HVAC system, the control system comprising:a damper associated with the predefined zone, the damper comprising:
a rail for securing the damper on an air duct of the predefined zone,
a blade assembly connected to the rail, the blade assembly having a damper module and a blade coupled to the damper module, wherein the damper module is configured to move the blade between an open and closed state to regulate air flow through the air duct,
a supplemental power source configured to supply power to the damper module, and
a scavenger assembly having an impeller and a scavenger module that stores power generated by rotation of the impeller in the air duct and supplies power to the damper module,
wherein the damper operates in a first mode using power supplied only by the scavenger module when air flow is greater than or equal to a predefined rate, and wherein the damper operates in a second mode using combination of power supplied by both the scavenger module and the supplemental power source when air flow is less than the predefined rate;
a wireless temperature controller associated with the damper, configured to monitor a zone temperature and humidity in the predefined zone, to receive as input data representative of a desired temperature for the predefined zone, and to communicate data representative of the temperature in the predefined zone and the desired temperature and to request service at the predefined zone; and
a control box in wireless communication with the damper and the wireless temperature controller, the control box configured to adjust a position of the blade to regulate the flow of forced air inside the air duct of the predefined zone based on the data representative of the zone temperature and the data representative of the desired temperature received from the temperature controller, wherein the control box is further coupled to the forced air HVAC system and configured to control operation of the forced air HVAC system.

US Pat. No. 10,190,791

THREE-DIMENSIONAL BUILDING MANAGEMENT SYSTEM VISUALIZATION

Crestron Electronics, Inc...

1. A system for on-demand rendering of a three-dimensional building management system visualization of a building comprising:a database configured for storing a geometry data file comprising geometry elements and a separate spatial data file comprising spatial elements, wherein the geometry elements define three-dimensional geometrical representation of a building's structure, wherein the spatial elements define three-dimensional representation of spaces in the building, wherein the geometry elements are mapped to spatial elements, wherein the spatial elements are associated with respective space nodes that identify the spaces located within the building, wherein the space nodes are associated with respective electronic devices installed within the spaces in the building; and
at least one processor in communication with the one or more electronic devices comprising a memory encoding one or more processor-executable instructions, which when executed by the at least one processor, cause acts to be performed comprising:
selectively recalling the geometry data file comprising the geometry elements and the spatial data file comprising the spatial elements from the database; and
rendering a three dimensional building visualization of the building via a user interface, wherein the three-dimensional building visualization comprises a status information visualization of at least one electronic device;wherein the user interface comprises:a structure selection field which upon being selected is configured for recalling the geometry elements from the geometry data file and visibly rendering at least a portion of the geometry elements;
a spaces selection field which upon being selected is configured for recalling the spatial elements from the spatial data file and visibly rendering at least a portion of the spatial elements; and
a structure and spaces selection field which upon being selected is configured for recalling the geometry elements from the geometry data file and the spatial elements from the spatial data file and visibly rendering at least a portion of the geometry elements and at least a portion of the spatial elements.

US Pat. No. 10,190,775

COMBUSTOR AND GAS TURBINE HAVING THE SAME

MITSUBISHI HITACHI POWER ...

1. A combustor comprising:a nozzle centered on a burner axis and configured to inject fuel;
a burner case having a tubular shape, surrounding an outer circumference of the nozzle, and being configured to inject air and the fuel from the nozzle from an upstream side in an axial direction in which the burner axis extends to a downstream side; and
a base plate spreading from a downstream end of the burner case in a radial direction based on the burner axis and defining a purging air space for purging air at an outer circumferential side of the burner case and an upstream side of the base plate,
wherein:
a purging air flow passage for injecting the purging air from the purging air space into the burner case or to the downstream side is defined in the burner case,
an inflow opening of the purging air flow passage for injecting the purging air is defined through a radially extending upstream-side surface of the base plate, and
an outflow opening of the purging air flow passage for injecting the purging air is defined within at least one of:
(i) a radial range from an inner circumferential surface of the burner case to a shorter of a radial plate thickness of a case forming plate defining the burner case and a value corresponding to an axial plate thickness of the base plate, and
(ii) an axial range from the downstream end of the burner case to a shorter of a value corresponding to the radial plate thickness of the case forming plate defining the burner case and the axial plate thickness of the base plate.

US Pat. No. 10,190,745

LAMP ASSEMBLY FOR USE IN A HEADLAMP

Valeo North America, Inc....

1. A lamp assembly for mounting in a headlamp comprising:a heat sink, said heat sink having a printed circuit board landing area for receiving a printed circuit board and a light source landing area for receiving at least one light source;
a light guide; and
a bracket for detachably mounting on said heat sink, said bracket being adapted to engage and secure said light guide in a predetermined position on said heat sink,
wherein said heat sink is an integral or monolithic construction and is processed or folded to comprise a plurality of walls for protecting said printed circuit board, said at least one light source and an electrical connection therebetween, and
wherein said plurality of walls comprises a first wall having at least one first wall aperture and a generally opposing second wall having at least one second wall aperture, said bracket comprising at least one first resilient arm and at least one second resilient arm each having a detent, said detent of said at least one first resilient arm being adapted to be received in said at least one first wall aperture and said detent of said at least one second resilient arm being adapted to be received in said at least one second wall aperture in order to secure or lock said bracket onto said heat sink.

US Pat. No. 10,190,741

LENS FOR LIGHTING DEVICE FOR MOTOR VEHICLES

VALEO VISION, Bobigny (F...

1. A lens for a lighting device of a motor vehicle, the lens comprising:a rear face designed to be oriented toward a light source of the lighting device;
a front face designed to be oriented toward the roadway being illuminated; and
a median vertical plane designed to be substantially orthogonal to the roadway, the front face having a first zone of diffusion with microstructures adapted to diffuse the light emitted by the light source, the first zone of diffusion extending in the median vertical plane, the front face including at least two second zones of diffusion, each one of the at least two second zones of diffusion having microstructures adapted to diffuse the light emitted by the light source, the at least two second zones of diffusion being situated on either side of the median vertical plane, the microstructures of the at least two second zones of diffusion having a depth greater than a depth of the microstructures of the first zone of diffusion, wherein
the front face includes a third zone of diffusion extending substantially orthogonally to the median plane, the third zone of diffusion extending from one lower end of both the first zone of diffusion and the at least two second zones of diffusion toward an end of the front face of the lens, and
the third zone of diffusion has microstructures adapted to diffuse the light emitted by the light source, the microstructures of the third zone having a depth substantially identical to the depth of the microstructures of the first zone of diffusion.

US Pat. No. 10,190,698

SOLENOID VALVES FOR HIGH VIBRATION ENVIRONMENTS

Marotta Controls, Inc., ...

1. A solenoid operated valve comprising:a valve block defining a valve lumen;
a poppet slidably disposed within the valve lumen;
a solenoid including a core defining a core lumen aligned with the valve lumen;
an armature assembly including an armature disc, an armature guide having a hollow cylindrical body defining an armature guide passage, and an armature stud disposed within the armature guide passage, wherein at least a portion of the armature guide and at least a portion of the armature stud are disposed within the core lumen, and wherein the armature stud is in communication with the poppet so that axial movement of one is translated into axial movement of the other;
a coil cover enclosing the solenoid; and
a guide ring disposed between the armature guide and the core in a radial direction extending from a central axis of the armature guide passage, wherein the guide ring moves relative to the core when the armature guide moves within the core lumen.

US Pat. No. 10,190,665

DRIVE SYSTEM FOR A VEHICLE, AND VEHICLE

Dr. Ing. h.c.F. Porsche A...

1. First and second drive systems provided respectively for first and second vehicles that have different power capacities, the drive systems comprisingthe first drive system comprising a first drive motor in a first drive motor housing; a first axle; a first gear chain disposed in a first gear chain housing that has opposite first and second sides, the first side of the first gear chain housing being connected to the first drive motor housing; and a first planetary transmission disposed in a first planetary transmission housing that is connected to the second side of the first gear chain housing, the first gear chain and the first planetary transmission being connected to one another for transmitting a driving torque generated by the first drive motor to the first axle of the first vehicle,
the second drive system comprising a second drive motor in a second drive motor housing; a second axle; a second gear chain disposed in a second gear chain housing that has opposite first and second sides, the first side of the second gear chain housing being connected to the second drive motor housing; and a second planetary transmission disposed in a second planetary transmission housing that is connected to the second side of the second gear chain housing, the second gear chain and the second planetary transmission being connected to one another for transmitting a driving torque generated by the second drive motor to the second axle of the second vehicle, wherein
the first axle and the second axle are identical to one another, the first gear chain and the second gear chain are identical to one another, the first gear chain housing and the second gear chain housing are identical to one another, the first drive motor and the second drive motor are different from one another in that the second drive motor has a different power capacity than the first drive motor and the first planetary transmission and the second planetary transmission are different from one another, and wherein
the first planetary transmission is coordinated with the first drive motor to determine a first overall transmission ratio for the first vehicle, and
the second planetary transmission is coordinated with the second drive motor to determine a second overall transmission ratio for the second vehicle.

US Pat. No. 10,190,650

COMPENSATING OSCILLATION DEVICE

AIM INFRAROT-MODULE GMBH,...

1. A linear piston system comprising:a piston supported to be linearly displaceable within a housing of the linear piston system; and
a compensating oscillation device configured to compensate vibrations generated by the piston, wherein the compensating oscillation device comprises:
a housing having an inside,
at least two coupling elements, wherein the at least two coupling elements are directly attached to the inside of the housing, and
an inertial mass coupled to the housing by the at least two coupling elements, such that the inertial mass is deflectable along an axis, wherein each coupling element comprises at least one attachment region and at least one connection region, wherein each coupling element is attached to the inside of the housing through the at least one attachment region and is connected to the inertial mass through the at least one connection region,
wherein on the at least two coupling elements, the respective at least one connection region lies radially closer to the axis than the respective at least one attachment region, and wherein in the rest state, the inertial mass is disposed between two coupling elements of the at least two coupling elements in the axial direction,
wherein the inertial mass is only provided within the housing of the compensating oscillation device and the piston is only provided within the housing of the linear piston system, wherein the housing of the compensating oscillation device and the housing of the linear piston system axially abut each other, such that the inertial mass and the piston are not directly coupled to each other,
wherein the compensating oscillation device is a passive compensating oscillation device that works only with restoring forces generated by the at least two coupling elements,
wherein the axial length of the inertial mass decreases monotonically and radially away from the axis, such that the mass distribution of the inertial mass is concentrated toward the axis,
wherein the piston is linearly displaceable within the housing of the linear piston in the axial direction,
wherein the piston comprises a working piston of a compressor, and
wherein each coupling element of the at least two coupling elements is connected to both the inertial mass and the housing of the compensating oscillation device by elastic pretension.

US Pat. No. 10,190,648

ACTUATING DEVICE FOR AN ELECTROMECHANICALLY ACTUATABLE VEHICLE BRAKE

Lucas Automotive GmbH, K...

1. An actuating device for an electromechanically actuatable vehicle brake, comprisinga multi-stage transmission unit, which is arranged between a driving electric motor and a driven drive element of the vehicle brake, wherein
at least one stage of the transmission unit is embodied as a spur-gear transmission, and at least two stages of the transmission unit are coupled by means of a double gearwheel, a rotational axis of the double gearwheel extends parallel to a rotational axis of the electric motor, and wherein
the transmission unit has at least one intermediate stage which is embodied as a spur-gear transmission and into which at least one stage, embodied as a spur-gear transmission, of the transmission unit is integrated, wherein
the intermediate stage which is embodied as a spur-gear transmission has two intermediate gearwheels; wherein
rotational axes of the intermediate gearwheels extend parallel to the rotational axis of the electric motor; and
wherein a plane formed by the rotational axes of the intermediate gearwheels extends perpendicularly with respect to the plane formed by the rotational axis of the electric motor and the rotational axis of the double gearwheel.

US Pat. No. 10,190,628

MAGNETIC BEARING AND CENTRIFUGAL COMPRESSOR

Green Refrigeration Equip...

1. A magnetic bearing, comprising:a revolving shaft;
an electromagnetic component comprising an iron core with a winding slot, and with coils arranged in the winding slot;
a thrust plate fixed on the revolving shaft; and
a protection mechanism configured to prevent the revolving shaft from colliding with the electromagnetic component;
wherein the electromagnetic component is arranged around an outer periphery of the revolving shaft; a gap is formed between the electromagnetic component and the revolving shaft to provide space for adjusting a position of the revolving shaft; and
wherein the protection mechanism is fixed in the winding slot on the electromagnetic component and arranged around an outer periphery of the thrust plate.

US Pat. No. 10,190,593

MAGNETIC DRIVE PUMP

ASSOMA INC., Taoyuan (TW...

1. A magnetic drive pump having a pump casing, an impeller, an inner rotor, a stationary shaft, a bracket, a liner and a containment shell;the pump casing made of cast iron or stainless steel being used for containing the impeller, which is for converting shaft power to hydraulic power;
the liner installed on a wetting side inside the pump for isolating a corrosive fluid;
the pump casing comprising a front support, an inlet, a volute, an outlet, a casing back flange and a casing liner;
the casing back flange positioned at a rear end of the pump casing for assembling the bracket and the containment shell;
the front support formed in an inner space of the inlet to be integrated with each other into one piece, the front support extending axially to be a cantilever structure for supporting the stationary shaft mating with the inner rotor to drive the impeller; and the magnetic drive pump being characterized in that:
the front support includes two rib plates, a cone body and a front shaft seat, the front support extends axially toward the inside of the pump casing;
the rib plates extend inward from an inner surface of the inlet of the pump casing and combine together at a center of an inner diameter, combining into a right angle structure where the two ribs are perpendicular to each other;
the cone body is formed at the combination of the two ribs plates and a center of the cone body corresponds to the center of the inner diameter of the inlet of the pump casing; the cone body extends inwardly towards a rear side of the pump casing;
the rib plates extend axially according to an axial length of the cone body and a width of the rib plates of the front support is gradually reduced to match with an outer diameter of the cone body, the cone body passes through a hub aperture of the impeller;
an outer surface of the front support is completely encapsulated with a corrosion resistant plastic and is integrated with the casing liner of the pump casing into one piece;
the impeller is axially shifted a distance with respect to the pump casing, which makes a flow center line of the outlet of the impeller positioned on an inner side of a center line of the outlet of the pump casing, to get a longer flow distance between the inlet of the pump casing and an inlet of the impeller;
a geometry of a shroud curve surface in a vicinity of a blade leading edge of the inlet of the impeller has an adequate radius of curvature, a hub plate near the stationary shaft and in the vicinity of the blade leading edge is a concave design matching with a cone curve surface of the cone body of the front shaft seat;
an inner diameter cylindrical inner surface of the inlet of the pump casing, a shroud curve surface and a shroud surface form a smooth surface with the impeller; the cone body axially extends to the inlet of the impeller with a conic surface, and the cone curve surface and a hub concave surface of a hub surface of the impeller also form a smooth curve surface; and
in the inner space of the inlet of the pump casing has a smooth variation of a cross-sectional area; the corrosive fluid enters the inlet of the pump casing and passes plate leading edges of the rib plates, a flow velocity of the corrosive fluid is increased and a minimum interference is achieved by the longer flow distance, and a flow is rectified by the rib plates.

US Pat. No. 10,190,563

INTERNAL COMBUSTION ENGINE IGNITION COIL AND METHOD FOR MANUFACTURING INTERNAL COMBUSTION ENGINE IGNITION COIL

Hitachi Automotive System...

1. An internal combustion engine ignition coil comprising:a central iron core;
a primary coil disposed on an outer circumference of the central iron core;
a secondary coil disposed on an outer circumference of the primary coil;
a side iron core disposed on an outer circumference of the secondary coil; and
an insulating material sealing the central iron core, the primary coil, and the secondary coil on an inner side of the side iron core, wherein
a first layered silicate having a particle diameter less than a winding diameter of the secondary coil is present at a higher concentration in a vicinity of the secondary coil than that in a vicinity of the side iron core in the insulating material,
a second layered silicate having a particle diameter greater than the winding diameter of the secondary coil is present at a higher concentration than that of the first layered silicate between the outer circumference side of the secondary coil and the side iron core, and
the second layered silicate has an aspect ratio of 50 or more, the aspect ratio being a ratio of a long side of a particle of the layered silicate to a thickness of the particle.

US Pat. No. 10,190,505

HOUSING FOR DRIVING AN APPARATUS FOR A TURBINE ENGINE

SAFRAN TRANSMISSION SYSTE...

1. A gearbox to be fixed to a turbine engine in order to drive at least one apparatus annexed to the turbine engine, the gearbox comprising:a housing;
a power take-off member capable of engaging with a radial shaft of the turbine engine;
at least one kinematic chain located inside the housing and capable of transmitting a rotational movement of a power take-off to at least one rotatable shaft of an apparatus, the kinematic chain comprising a first end and a second end, wherein the power take-off member is linked to the kinematic chain by a gear having convergent axes located within the kinematic chain;
wherein the kinematic chain comprises at least one central shaft capable of transmitting the movement of the power take-off member to at least one rotatable shaft of an apparatus through at least one intermediate gear, where the central shaft comprises two ends, the power take-off member being linked to the central shaft by a gear having convergent axes, located between the first end and the second end of the central shaft, the central shaft comprising a first and second part, with the power take-off member being linked to the first part by a first gear with convergent axes and to the second part by a second gear with convergent axes.

US Pat. No. 10,190,386

ZONE ISOLATION METHOD AND ANNULAR BARRIER WITH AN ANTI-COLLAPSING UNIT

Welltec Oilfield Solution...

1. An annular barrier to be expanded in an annulus between a well tubular structure and a wall of a borehole downhole for providing zone isolation between a first zone having a first pressure and a second zone having a second pressure of the borehole, the annular barrier comprising:a tubular metal part for mounting as part of the well tubular structure, the tubular metal part having an outer face,
an expandable sleeve surrounding the tubular metal part and having an inner face facing the tubular metal part and an outer face facing the wall of the borehole, each end of the expandable sleeve being connected with the tubular metal part, and
an annular space between the inner face of the expandable sleeve and the tubular metal part, the annular space having a space pressure,
wherein the annular barrier comprises an anti-collapsing unit comprising an element movable at least between a first position and a second position, the anti-collapsing unit having a first inlet which is in fluid communication with the first zone, and a second inlet which is in fluid communication with the second zone, and the anti-collapsing unit having an outlet which is in fluid communication with the annular space, and in the first position, the first inlet is in fluid communication with the outlet, equalising the first pressure of the first zone with the space pressure, and in the second position, the second inlet is in fluid communication with the outlet, equalising the second pressure of the second zone with the space pressure.

US Pat. No. 10,190,275

PAVEMENT SWEEPER WITH CONVEYOR LIFT-OUT DROP-IN SYSTEM

SCHWARZE INDUSTRIES, INC....

1. A motorized wheeled roadway vehicle for sweeping debris from a roadway surface, comprising:a debris receiving container;
a conveyor configured for conveying debris swept from the roadway surface to the debris receiving container, the conveyor having first and second stub shafts, the first stub shaft extending laterally outward from a first side of the conveyor and the second stub shaft extending laterally outward from a second side of the conveyor;
a rotatable broom configured for engagement with the roadway surface to sweep debris therefrom onto the conveyor for conveying the debris to the debris receiving container;
a cradle configured for supporting the conveyor and having first and second stub shaft receiving formations, each formation having a first part connected to the vehicle and having a semi-cylindrical surface configured for receiving the respective stub shaft and having a second removable part having a semi-cylindrical surface, the second removable part and the first part removeably secured together so that the semi-cylindrical surfaces define a bore configured for receiving the respective stub shaft; and
the second removeable parts selectively removeable from the respective first parts to present the stub shafts and the conveyor for removal from the first parts of said formations in a substantially vertical direction.

US Pat. No. 10,190,266

REINFORCED RUBBER GROUND COVER MAT

Champagne Edition, Inc., ...

1. A ground cover mat comprising:(a) a slab made of a slab material comprising rubber, the slab defining a horizontally extending lower major surface of the ground cover mat and a horizontally extending upper major surface of the ground cover mat; and
(b) a core assembly encased by the slab and disposed vertically between the lower major surface and the upper major surface of the ground cover mat, the core comprising:
(i) a plurality of boards extending horizontally along a majority of the length of the slab and disposed in horizontally spaced apart side-by-side relation with each other; and
(ii) a rebar mesh disposed on top of and in contact with the plurality of boards, the rebar mesh comprising a first plurality of horizontally extending rebars disposed in horizontally spaced apart side-by-side relation with each other, and a second plurality of horizontally extending rebars disposed in horizontally spaced apart side-by-side relation with each other, wherein the rebars of the second plurality of rebars are oriented transversely to and in contact with the rebars of the first plurality of rebars;
wherein the first plurality of rebars are in contact with the boards and disposed vertically between the boards and the second plurality of rebars, or the rebars of the second plurality of rebars are in contact with the boards and disposed vertically between the boards and the first plurality of rebars: and
wherein the rubber of the slab material fills spaces between the rebars of the rebar mesh and the boards.

US Pat. No. 10,190,264

MULTI-FUNCTIONAL RAILWAY FASTENING COMPONENT ADJUSTMENT SYSTEM

MOW Equipment Solutions, ...

1. A multi-functional railway fastening component adjustment system comprising:a railway component adjuster comprising:
a tool bracket;
one or more adjustment tools pivotally coupled with the tool bracket;
one or more tool actuators coupled with the one or more adjustment tools and the tool bracket, the one or more tool actuators adapted to cause pivotal movement of the one or more adjustment tools with respect to the tool bracket; and
a main bracket comprising one or more attachment components to couple the railway component adjuster to a frame structure;
the railway component adjuster configured to selectively engage each railway fastening component of a plurality of railway fastening components from a plurality of different addressing positions of the one or more adjustment tools at least in part by pivoting to a selected addressing position of the plurality of different addressing positions, wherein:
the plurality of railway fastening components comprises a railway anchor and a railway tie plate;
the railway component adjuster is adapted to hold the one or more adjustment tools in the selected addressing position to make a component adjustment to the railway fastening component with the one or more adjustment tools; and
the component adjustment comprises movement of the railway fastening component along a rail of a railway.

US Pat. No. 10,190,258

DOCTOR BLADE HOLDERS AND DOCTOR BLADE HOLDER SYSTEMS INCLUDING PLANAR ELEMENTS WITH THREE DIMENSIONAL FABRIC REINFORCEMENT MATERIALS

Kadant Inc., Westford, M...

1. A planar element for use in a papermaking system, said planar element being suitable for use as a doctor blade or a top plate, said planar element comprising:a three-dimensional composite structure including elongated elements extending in at least three orthogonal directions; and
a resin in which the three-dimensional composite structure is embedded.

US Pat. No. 10,190,257

WIRE CABLE AND METHOD AND DEVICE FOR PRODUCTION OF SAID WIRE CABLE

CASAR DRAHTSEILWERK SAAR ...

1. A method for producing a wire cable, comprising the steps of: precompacting a core cable and afterwards compacting the core cable by hammering to smooth an outer surface of the core cable and increase flexibility and bending strength of the wire cable; applying a plastic layer to the core cable; softening the plastic layer; subsequently twisting multiwire strands onto the core cable covered by the softened plastic layer and pressing the multiwire strands into the softened plastic layer; and hammering the wire cable after the multiwire strands are twisted on the core cable and pressed into the plastic layer.

US Pat. No. 10,190,239

TEXTILE PART, COMPOSITE MATERIAL ELEMENT WITH TEXTILE PART, AND PRODUCTION METHOD FOR THE SAME

Groz-Beckert KG, Albstad...

1. A textile part (10) for use in composite materials, the textile part (10) comprising:a reinforcing system (15) of reinforcing warp threads (17) and reinforcing weft threads (16),
at least one first portion (20) of the textile part and at least one second portion (21) of the textile part,
wherein the reinforcing warp threads (17) and the reinforcing weft threads (16) in the first portion (20) of the textile part are directly bound to each other by direct weave binding,
wherein the reinforcing warp threads (17) in the second portion (21) of the textile part are placed on the reinforcing weft threads (16), without direct weave binding with the reinforcing warp threads (17),
wherein the second portion (21) of the textile part is bordered on several sides by one or more first portions (20) of the textile part, and/or wherein the reinforcing system (15) in the second portion (21) of the textile part is enclosed between the binding weft threads (26) and the binding warp threads (27) of a binding system (25), said binding warp and weft threads being bound together at binding locations (35).

US Pat. No. 10,190,205

METHOD AND APPARATUS FOR FLAME SPRAYING THERMOPLASTIC POWDERS

IBIX S.R.L., Santa Maria...

1. An apparatus for flame spraying thermoplastic powders, the apparatus comprising:a spray gun configured to perform spraying of thermoplastic powders and to be fed with a liquefied petroleum gas for producing a flame to be directed on an article to be coated in order to heat a surface of said article to a predetermined working temperature, said spray gun comprising a mixing device internally defining separated discharge chambers, said separated discharge chambers being configured to be fed with said thermoplastic powders to be sprayed with a transport inert gas, with a flow of compressed air and/or nitrogen and with said liquefied petroleum gas, and said spray gun comprising a mixing chamber communicating with said separated discharge chambers;
a flame ignition device for igniting said flame, connected to said spray gun and said flame ignition device comprising a spark ignition device, and a conductor element associated with said mixing device and said conductor element being connected to said spark ignition device so as to produce a spark at said mixing chamber;
a flame detection and monitor device configured to detect and monitor a presence of said flame;
an actuator means for interrupting or enabling a feed of the liquefied petroleum gas, said flame detection and monitor device being connected, directly or indirectly, with said actuator means, said spark ignition device comprising a piezoelectric spark ignition device fixed to said mixing device, said piezoelectric spark ignition device being provided with an activation means, said flame detection and monitor device comprises a temperature detection means associated with said mixing device;
a duct for feeding said liquefied petroleum gas in communication with one of said separated discharge chambers configured to be fed with said liquefied petroleum gas, said actuator means comprising a valve associated with said duct and said valve being housed in an external tubular element mounted on an end of said spray gun so as to intersect said duct, said valve being connected with said temperature detection means and said spark ignition device being mounted in a fixed manner on said external tubular element.

US Pat. No. 10,190,200

ALUMINUM-COPPER-LITHIUM PRODUCTS

CONSTELLIUM ISSOIRE, Iss...

1. A method of manufacturing an extruded product based on an aluminum alloy, said method comprising:a) preparing a liquid metal bath consisting essentially of 2.72 to 3.1% by weight of Cu, 1.59 to 1.8% by weight of Li, 0.1 to 0.5% by weight of Ag, 0.1 to 1.0% by weight of Mg, 0.05 to 0.18% by weight of Zr, 0.2 to 0.6% by weight of Mn, and at least one element selected from Cr, Sc, Hf and Ti, the quantity of said element, if included, being 0.05 to 0.3% by weight for Cr and for Sc, 0.05 to 0.5% by weight for Hf or 0.01 to 0.15% by weight for Ti,
remainder aluminum and inevitable impurities;
b) casting an unwrought shape from said liquid metal bath;
c) homogenizing said unwrought shape at a temperature from 515° C. to 525° C. such that the equivalent time for homogenization

is from 5 to 20 hours, where T (in Kelvin) is the instantaneous treatment temperature, which varies with the time t (in hours), and Tref is a reference temperature set at 793 K;
d) hot working and optionally cold working said unwrought shape into an extruded product;
e) subjecting the product to a solution treatment and quenching;
f) stretching said product with a permanent set of 1 to 5%; and
g) artificially aging said product by heating at 140 to 170° C. for 5 to 70 hours such that said product has a yield strength measured at 0.2% elongation in the L-direction of at least 517 MPa.

US Pat. No. 10,190,184

METHOD FOR PRODUCING A PROFILE AND A MANUFACTURING SYSTEM FOR PRODUCING A PROFILE

THYSSENKRUPP STEEL EUROPE...

1. A method for producing a profile, comprising the following method steps:providing a workpiece,
shaping the workpiece,
joining the workpiece,
coating the workpiece,
heating the workpiece, and
at least partially hardening the workpiece,
wherein the coating method step is carried out temporally after the joining method step and temporally before the heating method step and the coated workpiece is hardened in a shaping manner in a hardening tool.

US Pat. No. 10,190,107

MODIFIED ?-GALACTOSIDASE

Amano Enzyme Inc., Nagoy...

1. A ?-galactosidase comprising an amino acid sequence which is different from a reference ?-galactosidase amino acid sequence in that one or more amino acids selected from the group consisting of the following (1) to (3) is/are proline, wherein the reference ?-galactosidase amino acid sequence shows a 90% or more identity to the amino acid sequence of SEQ ID NO: 4:(1) an amino acid corresponding to lysine at position 166 of the amino acid sequence of SEQ ID NO: 4;
(2) an amino acid corresponding to glycine at position 307 of the amino acid sequence of SEQ ID NO: 4; and
(3) an amino acid corresponding to alanine at position 833 of the amino acid sequence of SEQ ID NO: 4.

US Pat. No. 10,190,101

PRODUCTION OF LACTIC ACID FROM ORGANIC WASTE OR BIOGAS OR METHANE USING RECOMBINANT METHANOTROPHIC BACTERIA

STRING BIO PRIVATE LIMITE...

1. A recombinant methanotrophic bacterium capable of producing lactic acid from organic waste or biogas or methane, comprisinga heterologous nucleic acid or gene encoding for lactate dehydrogenase (ldh) enzyme, having the sequence of SEQ ID NO: 1, 3, or 5, or a combination thereof.

US Pat. No. 10,190,021

FLOOR COATING COMPOSITIONS AND FLOORING MATERIAL

DEXERIALS AMERICA CORPORA...

1. A floor coating composition used for coating of a floor and comprising components (A) to (E) below as essential components:component (A): a bifunctional (meth)acrylate compound not having an alicyclic structure;
component (B1): a trifunctional or more urethane (meth)acrylate oligomer;
component (B2): a hexafunctional or more urethane (meth)acrylate oligomer other than the component (B1);
component (C): a melamine (meth)acrylate;
component (D): metal oxide nanoparticles; and
component (E): an active energy ray polymerization initiator,
wherein the amount of component (A) contained is more than 24 weight % and less than 50 weight %, the amount of component (B1) contained is more than 10 weight % and less than 35 weight %, the amount of component (B2) contained is not less than 10 weight % and not more than 15 weight %, and the amount of component (C) contained is not less than 10 weight % and less than 20 weight %, and
wherein component (E) contains a hydrogen abstraction photopolymerization initiator.

US Pat. No. 10,189,949

TRANSPARENT POLYIMIDE COPOLYMER, POLYIMIDE RESIN COMPOSITION AND MOLDED ARTICLE, AND PRODUCTION METHOD OF SAID COPOLYMER

SOMAR CORPORATION, Tokyo...

1. A transparent polyimide copolymer obtained by copolymerizing:(A) 4,4?-oxydiphthalic dianhydride; and
(B) at least one diamine and/or diisocyanate represented by the following Formulae (1) or (2):

(wherein, X represents an amino group or an isocyanate group; R1 to R4 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; and at least one of said R1 to R4 is not a hydrogen atom).

US Pat. No. 10,189,927

IONOMER HAVING HIGH OXYGEN PERMEABILITY

DAIKIN INDUSTRIES, LTD., ...

1. An ionomer, comprising:a repeating unit A;
a repeating unit B, and
a repeating unit C,
the ionomer having an equivalent weight of 250 to 930 and a glass transition temperature of 100° C. to 130° C.,
the amount of the repeating unit B is 16 to 45 mol %, relative to all the repeating units,
the repeating unit B being represented by the formula (2):
wherein Rp represents a monovalent group having a proton exchange group,wherein the repeating unit A is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (3):
wherein m3 represents an integer of 2 to 6; anda repeating unit represented by the formula (4):
wherein Y41 represents F or a C1-C3 perfluoroalkyl group; k4 represents 0 or 1; n4 represents an integer of 1 to 8; when n4 represents an integer of 2 to 8, Y41 in each of respective units —(CF2CFY41—O)n4— may be the same as or different from each other; and m4 represents an integer of 1 to 6,wherein the repeating unit C that is at least one repeating unit selected from the group consisting of:
a repeating unit represented by the formula (7):
wherein Rf71 represents F, Cl, or a C1-C9 linear or branched fluoroalkyl group, anda repeating unit represented by the formula (8):
wherein Y81 represents H or F; Y82 represents F or a C1-C9 linear or branched fluoroalkyl group;and Y83 represents H, F, Cl, or a C1-C9 linear or branched fluoroalkyl group.

US Pat. No. 10,189,869

AMINO COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS

Achillion Pharmaceuticals...

1. A method for the treatment of a disorder mediated by complement D selected from paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and C3 glomerulonephritis comprising administering an effective amount to a human in need thereof of a compound of Formula I,or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, wherein:Q1 is C(R1R1?);
Q2 is C(R2R2?);
Q3 is C(R3R3?);
X1 isle;
X2 is CH;
R1, R1?, R2, R2?, R3, and R3? are independently chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C2-C6alkynyl, C2-C6alkanoyl, C1-C6thioalkyl, hydroxyC1-C6alkyl, aminoC1-C6alkyl, —C0-C4alkylR9R10, —C(O)OR9, —OC(O)R9, —NR9C(O)R10, —C(O)NR9R10, —OC(O)NR9R10, —NR9C(O)OR10, C1-C2haloalkyl, and C1-C2haloalkoxy,
or R1 and R2 form a 3- to 6-membered carbocyclic or aryl ring;
or R2 and R3 form a 3- to 6-membered carbocyclic ring;
or R1 and R1?, or R2 and R2?, or R3 and R3? form a 3- to 6-membered carbocyclic Spiro ring;
or R2 and R2? or R3 and R3? form a 3- to 6-membered heterocyclic spiro ring;
each of which ring is unsubstituted or substituted with 1 or more substituents independently, chosen from halogen, hydroxyl, cyano, —COOH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, hydroxyC1-C4alkyl, (mono- and di-C1-C4alkylamino)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), —O—C0-C4alkyl(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
or R1 and R1?, R2 and R2?, or R3 and R3? form a carbonyl group;
or R1 and R2 or R2 and R3 form a carbon-carbon double bond;
R9 and are independently chosen at each occurrence from hydrogen, C1-C6alkyl, (C3-C7cycloalkyl)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), and —O—C0-C4alkyl(C3-C7cycloalkyl);
A is a group selected from:

R5 and R6 are independently selected from CHO, —C(O)NH2, —C(O)NH(CH3), C2-C6alkanoyl, hydrogen, hydroxyl, halogen, cyano, nitro, —COOH, —SO2NH2, vinyl, C1-C6alkyl (including methyl), C2-C6alkenyl, C1-C6alkoxy, —C0-C4alkyl(C3-C7cycloalkyl), —C(O)C0-C4alkyl(C3-C7cycloalkyl), —P(O)(OR9)2, —OC(O)R9, —C(O)OR9, —C(O)N(CH2CH2R9)(R10), —NR9C(O)R10, phenyl, or 5- to 6-membered heteroaryl; and wherein each R5 and R6 other than hydrogen, hydroxyl, cyano, and COOH is unsubstituted or optionally substituted;
R8 and R8? are hydrogen;
X11 is N or CR11;
X12 is N or CR12;
X13 is N or CR13;
X14 is N or CR14, and wherein no more than two of X11, X12, X13, and X14 are N;
one of R12 and R13 is chosen from R31 and the other of R12 and R13 is chosen from R32;
R31 is chosen from hydrogen, halogen, hydroxyl, nitro, cyano, amino, —COOH, C1-C2haloalkyl, C1-C2haloalkoxy, —C0-C4alkyl(C3-C7cycloalkyl), C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, C2-C6alkenyloxy, —C(O)OR9, C1-C6thioalkyl, —C0-C4alkylNR9R10, —C(O)NR9R10, —SO2R9, —SO2NR9R10, —OC(O)R9, and —C(NR9)NR9R10, each of which R31 other than hydrogen, halogen, hydroxyl, nitro, cyano, C1-C2haloalkyl, and C1-C2haloalkoxy is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, amino, —COON, —CONH2, C1-C2haloalkyl, and C1-C2haloalkoxy, and each of which R31 is also optionally substituted with one substituent chosen from phenyl and 4- to 7-membered heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S; which phenyl or 4- to 7-membered heterocycle is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl)(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
R32 is NR37R38, NR9SO2R38, or N(SO2R9)CH2C(O)R39;
R11, R14, and R15 are independently chosen at each occurrence from hydrogen, halogen, hydroxyl, nitro, cyano, —O(PO)(OR9)2, —(PO)(OR9)2; C2-C6alkenyl, C2-C6alkynyl, C2-C6alkanoyl, C1-C6alkoxy, C1-C6thioalkyl, —C0-C4alkyl(mono- and di-C1-C6alkylamino), —C0-C4alkyl(C3-C7cycloalkyl), —C0-C4alkoxy(C3-C7cycloalkyl), C1-C2haloalkyl and C1-C2haloalkoxy;
R37 is aryl, heteroaryl, heterocycle, (aryl)C0-C4alkyl, (heterocycle)C0-C4alkyl, (heteroaryl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, —S(O)(O)(alkyl), —S(O)(alkyl), —S(O)(O)(heteroalkyl), —S(O)(heteroalkyl), —S(O)(O)(aryl), —S(O)(aryl), —S(O)(O)(heteroaryl), —S(O)(heteroaryl);
R38 is hydrogen, hydroxyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, or —C1-C4alkylC(O)OC1-C6alkyl;
R21 and R22 are independently chosen at each occurrence from hydrogen, hydroxyl, cyano, amino, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy; (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R21 and R22 can be optionally substituted;
R23 is independently chosen at each occurrence from C1-C6alkyl, C1-C6haloalkyl, (aryl)C0-C4alkyl, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and each R23 can be optionally substituted;
R24 and R25 are taken together with the nitrogen to which they are attached to form a 4- to 7-membered monocyclic heterocycloalkyl group, or a 6- to 10-membered bicyclic heterocyclic group having fused, spiro, or bridged rings, and each R24 and R25 can be optionally substituted;
L is

R17 is hydrogen;
R18 and R18? are independently chosen from hydrogen, halogen, hydroxymethyl, and methyl;
m is 0, 1, 2, or 3;
B is a monocyclic or bicyclic carbocyclic; a monocyclic or bicyclic carbocyclic-oxy group;
a monocyclic, bicyclic, or tricyclic heterocyclic group having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and from 4 to 7 ring atoms per ring; C2-C6alkenyl, C2-C6alkynyl; -(C0-C4alkyl)(aryl); -(C0-C4alkyl)(heteroaryl); or -(C0-C4alkyl)(biphenyl) each of which B is unsubstituted or substituted with one or more substituents independently chosen from R33 and R34, and 0 or 1 substituents chosen from R35 and R36;
R33 is independently chosen from halogen, hydroxyl, —COOH, cyano, C1-C6alkyl, C2-C6alkanoyl, C1-C6alkoxy, —C0-C4alkylNR9—SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy;
R34 is independently chosen from nitro, C2-C6alkenyl, C2-C6alkynyl, C1-C6thioalkyl, —C3-C7cycloalkyl, —B(OH)2, -JC(O)NR9R23, -JOSO2OR21, —C(O)(CH2)1-4S(O)R21, —O(CH2)1-4S(O)NR21R22, -JOP(O)(OR21)(OR22), -JP(O)(OR21)(OR22), -JOP(O)(OR21)R22, -JP(O)(OR21)R22, -JOP(O)R21R22, -JP(O)R21R22, -JSP(O)(OR21)(OR22), SP(O)(OR21)(R22), -JSP(O)(R21)(R22), -JNR9P(O)(NHR21)(NHR22), -JNR9P(O)(OR21)(NHR22), -JNR9P(O)(OR21)(OR22), -JC(S)R21, -JNR21SO2R22, -JNR9S(O)NR10R22, -JNR9SO2NR10R22, -JSO2NR9COR22, JSO2NR9CONR21R22, -JNR21SO2R22, -JC(O)NR21SO2R22, -JC(NH2)NR22, -JC(NH2)NR9S(O)2R22, -JOC(O)NR21R22, -JNR21C(O)OR22, -JNR21OC(O)R22, —(CH2)1-4C(O)NR21R22, -JC(O)R24R25, -JNR9C(O)R21, -JC(O)R21, -JNR9C(O)NR10R22, —CCR21, —(CH2)1-4OC(O)R21, and -JC(O)OR23; each of which R34 may be unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, amino, oxo, —B(OH)2, —Si(CH3)3, —COOH, —CONH2, —P(O)(OH)2, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C1-C6alkoxy, —C0-C2alkyl(mono- and di-C1-C4alkylamino), C1-C6alkylester, C1-C4alkylamino, C1-C4hydroxylalkyl, C1-C2haloalkyl, and C1-C2haloalkoxy;
R35 is independently chosen from naphthyl, naphthyloxy, indanyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl containing 1 or 2 heteroatoms chosen from N, O, and S, and bicyclic heterocycle containing 1, 2, or 3 heteroatoms independently chosen from N, O, and S, and containing 4- to 7-ring atoms in each ring, each of which R35 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy; and
R36 is independently chosen from tetrazolyl, (phenyl)C0-C2alkyl, (phenyl)C1-C2alkoxy, phenoxy, and 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently chosen from N, O, B, and S, each of which R36 is unsubstituted or substituted with one or more substituents independently chosen from halogen, hydroxyl, nitro, cyano, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, —OSi(CH3)2C(CH3)3, —Si(CH3)2C(CH3)3, C1-C2haloalkyl, and C1-C2haloalkoxy; and
J is independently selected at each occurrence from a covalent bond, C1-C4alkylene, —OC1-C4alkylene, C2-C4alkenylene, and C2-C4alkynylene.

US Pat. No. 10,189,834

IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER

AstraZeneca AB, Sodertal...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, where:Q is a cyclobutyl or cyclopentyl ring, each of which is optionally substituted by one hydroxy or methoxy group, or Q is an oxetanyl, tetrahydrofuranyl or oxanyl ring, each of which is optionally substituted by one methyl group;
R1 is methyl;
R2 is hydrogen or methyl; or R1and R2 together form an azetidinyl, pyrrolidinyl or piperidinyl ring;
R3 is hydrogen or fluoro;
R4 is hydrogen or methyl; and
R5 is hydrogen or fluoro.

US Pat. No. 10,189,831

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
M is CH2;
Z is

each R1 is independently selected from the group consisting of: halogen, CN, NO2, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, OH, O—C1-4 alkyl, O—C1-4 haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, SO2RA, SO2N(RA)RB, SO2N(RA)C(O)RB or C2-4 alkenyl substituted with CN;
R2 is selected from the group consisting of:
(1) H,
(2) C1-6 alkyl,
(3) C1-6 haloalkyl,
(4) C1-6 alkyl substituted with from 1 to 3 substituents each of which is independently OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(5) O—C1-6 alkyl in which the alkyl is optionally substituted with 1 to 3 substituents independently selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, or S(O)2N(RA)RB,
(6) O—C1-6 haloalkyl,
(7) halogen,
(8) CN,
(9) NO2,
(10) N(RA)RB,
(11) C(O)N(RA)RB,
(12) C(O)RA,
(13) C(O)—C1-6 haloalkyl,
(14) C(O)ORA,
(15) OC(O)RA,
(16) OC(O)N(RA)RB,
(17) SRA,
(18) S(O)RA,
(19) S(O)2RA,
(20) S(O)2N(RA)RB,
(21) N(RA)S(O)2RB,
(22) N(RA)S(O)2N(RA)RB,
(23) N(RA)C(O)RB,
(24) N(RA)C(O)N(RA)RB,
(25) N(RA)C(O)—C(O)N(RA)RB,
(26) N(RA)CO2RB,
(27) N(RC)RD,
(28) C(O)N(RC)RD,
(29) OC(O)N(RC)RD,
(30) S(O)2N(RC)RD,
(31) N(RA)S(O)2N(RC)RD,
(32) N(RA)C(O)N(RC)RD,
(33) N(RA)C(O)—C(O)N(RC)RD,
(34) CycA,
(35) —O-CycA,
(36) ArylA, or
(37) HetA;
R3 is H, C1-6 alkyl, halogen, CN, C1-6 fluoroalkyl, OH, O—C1-6 alkyl or O—C1-6 haloalkyl;
R4 and R5 are each independently selected from:
(1) H,
(2) C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, each optionally substituted with one or more substituents up to the maximum number allowed by valence selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, N(RA)C(O)C(O)N(RA)RB, CycB, ArylB and HetB,
(3) C1-6 haloalkyl optionally additionally substituted with one or more substituents up to the maximum number allowed by valence selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, N(RA)C(O)C(O)N(RA)RB, CycB, ArylB and HetB
(4) O—C1-6 alkyl in which the alkyl portion is optionally substituted with one or more substituents up to the maximum number allowed by valence selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, N(RA)C(O)C(O)N(RA)RB, CycB, ArylB and HetB,
(5) O—C1-6 haloalkyl, optionally additionally substituted with one or more substituents up to the maximum number allowed by valence selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, N(RA)C(O)C(O)N(RA)RB, CycB, ArylB and HetB,
(6) halogen,
(7) CN,
(8) NO2,
(9) N(RA)RB,
(10) C(O)N(RA)RB,
(11) C(O)RA,
(12) C(O)—C1-6 haloalkyl,
(13) C(O)ORA,
(14) OC(O)RA,
(15) OC(O)N(RA)RB,
(16) SRA,
(17) S(O)RA,
(18) S(O)2RA,
(19) S(O)2N(RA)RB,
(20) N(RA)S(O)2RB,
(21) N(RA)S(O)2N(RA)RB,
(22) N(RA)C(O)RB,
(23) N(RA)C(O)N(RA)RB,
(24) N(RA)C(O)—C(O)N(RA)RB,
(25) N(RA)CO2RB,
(26) N(RC)RD,
(27) C(O)N(RC)RD,
(28) OC(O)N(RC)RD,
(29) S(O)2N(RC)RD,
(30) N(RA)S(O)2N(RC)RD,
(31) N(RA)C(O)N(RC)RD,
(32) N(RA)C(O)—C(O)N(RC)RD,
(33) OH,
(34) CycB,
(35) ArylB,
(36) HetB,
(37) -J-CycB,
(38) -J-ArylB, and
(39) -J-HetB,
or R4 and R5 on adjacent atoms may be joined together with the atoms to which they are attached to form a fused CycC, ArylC or HetC;
CycA, CycB and CycC are independently a carbocyclyl which is a C3-8 cycloalkyl, a C5-8 cycloalkenyl, or a C7-12 bicyclic, saturated or unsaturated, non-aromatic ring system wherein one ring is fused to or bridged with the other ring; wherein the carbocyclyl is optionally substituted with a total of from 1 to 6 sub stituents, wherein:
(i) from zero to 6 substituents are each independently:
(1) halogen,
(2) CN,
(3) C1-6 alkyl,
(4) OH,
(5) O—C1-6 alkyl,
(6) C1-6 haloalkyl,
(7) O—C1-6 haloalkyl,
(8) C1-6 alkenyl, or
(9) C1-6 alkenyl substituted with CN, and
(ii) from zero to 2 substituents are each independently:
(1) CycQ,
(2) AryQ,
(3) HetQ,
(4) HetR,
(5) J-CycQ,
(6) J-AryQ,
(7) J-HetQ,
(8) J-HetR,
(9) C1-6 alkyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR,
(10) C2-6 alkenyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR, or
(11) C2-6 alkynyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR;
ArylA, ArylB and ArylC are independently aryl which is optionally substituted with a total of from 1 to 8 substituents, wherein:
(i) from zero to 8 substituents are each independently:
(1) C1-6 alkyl,
(2) C1-6 haloalkyl, which is optionally substituted with 1 to 3 additional substituents each of which is independently selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(3) C1-6 alkyl substituted with from 1 to 3 substituents each of which is independently selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(4) C2-6 alkenyl,
(5) C2-6 alkenyl substituted with from 1 to 3 substituents each of which is independently OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(6) C2-6 alkynyl,
(7) C2-6 alkynyl substituted with from 1 to 3 substituents each of which is independently OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(8) O—C1-6 alkyl,
(9) O—C1-6 haloalkyl,
(10) OH,
(11) halogen,
(12) CN,
(13) NO2,
(14) N(RA)RB,
(15) C(O)N(RA)RB,
(16) C(O)RA,
(17) C(O)—C1-6 haloalkyl,
(18) C(O)ORA,
(19) OC(O)N(RA)RB,
(20) SRA,
(21) S(O)RA,
(22) S(O)2RA,
(23) S(O)2N(RA)RB,
(24) N(RA)S(O)2RB,
(25) N(RA)S(O)2N(RA)RB,
(26) N(RA)C(O)RB,
(27) N(RA)C(O)N(RA)RB,
(28) N(RA)C(O)—C(O)N(RA)RB, or
(29) N(RA)CO2RB, and
(ii) from zero to 2 substituents are each independently:
(1) CycQ,
(2) AryQ,
(3) HetQ,
(4) HetR,
(5) J-CycQ,
(6) J-AryQ,
(7) J-HetQ,
(8) J-HetR,
(9) C1-6 alkyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR,
(10) C2-6 alkenyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR, or
(11) C2-6 alkynyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR;
HetA, HetB and HetC are independently a heterocyclyl or heteroaryl which is optionally substituted with a total of from 1 to 8 substituents, wherein:
(i) from zero to 8 substituents are each independently:
(1) C1-6 alkyl,
(2) C1-6 haloalkyl, which is optionally substituted with 1 to 3 additional substituents each of which is indepednently selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(3) C1-6 alkyl substituted with from 1 to 3 substituents each of which is independently selected from OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(4) C2-6 alkenyl,
(5) C2-6 alkenyl substituted with from 1 to 3 substituents each of which is independently OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(6) C2-6 alkynyl,
(7) C2-6 alkynyl substituted with from 1 to 3 substituents each of which is independently OH, O—C1-6 alkyl, O—C1-6 haloalkyl, CN, NO2, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, S(O)2RA, S(O)2N(RA)RB, N(RA)C(O)RB, N(RA)CO2RB, N(RA)S(O)2RB, N(RA)S(O)2N(RA)RB, OC(O)N(RA)RB, N(RA)C(O)N(RA)RB, or N(RA)C(O)C(O)N(RA)RB,
(8) O—C1-6 alkyl,
(9) O—C1-6 haloalkyl,
(10) OH,
(11) oxo,
(12) halogen,
(13) CN,
(14) NO2,
(15) N(RA)RB,
(16) C(O)N(RA)RB,
(17) C(O)RA,
(18) C(O)—C1-6 haloalkyl,
(19) C(O)ORA,
(20) OC(O)N(RA)RB,
(21) SRA,
(22) S(O)RA,
(23) S(O)2RA,
(24) S(O)2N(RA)RB,
(25) N(RA)S(O)2RB,
(26) N(RA)S(O)2N(RA)RB,
(27) N(RA)C(O)RB,
(28) N(RA)C(O)N(RA)RB,
(29) N(RA)C(O)—C(O)N(RA)RB, or
(30) N(RA)CO2RB, and
(ii) from zero to 2 substituents are each independently:
(1) CycQ,
(2) AryQ,
(3) HetQ,
(4) HetR,
(5) J-CycQ,
(6) J-AryQ,
(7) J-HetQ,
(8) J-HetR,
(9) C1-6 alkyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR,
(10) C2-6 alkenyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR, or
(11) C2-6 alkynyl substituted with CycQ, AryQ, HetQ, HetR, J-CycQ, J-AryQ, J-HetQ, or J-HetR;
each CycQ is independently C3-8 cycloalkyl or C5-8 cycloalkenyl, wherein the cycloalkyl or cycloalkenyl is optionally substituted with from 1 to 4 substituents, each of which is independently halogen, C1-6 alkyl, OH, O—C1-6 alkyl, C1-6 haloalkyl, or O—C1-6 haloalkyl;
each AryQ is independently phenyl or naphthyl, wherein the phenyl or naphthyl is optionally substituted with from 1 to 5 substituents each of which is independently halogen, CN, NO2, C1-6 alkyl, C1-6 haloalkyl, OH, O—C1-6 alkyl, O—C1-6 haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SRA, S(O)RA, SO2RA, SO2N(RA)RB, or SO2N(RA)C(O)RB;
each HetQ is independently a heteroaryl which is optionally substituted with from 1 to 4 substituents each of which is independently halogen, C1-6 alkyl, C1-6 haloalkyl, OH, O—C1-6 alkyl, O—C1-6 haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, SO2RA, N(RA)c(O)N(RA)RB, or N(RA)CO2RB;
each HetR is independently a 4- to 7-membered, saturated or unsaturated, non-aromatic heterocyclic ring containing at least one carbon atom and from 1 to 4 heteroatoms independently selected from N, O and S, where each S is optionally oxidized to S(O) or S(O)2, and wherein the saturated or unsaturated heterocyclic ring is optionally substituted with from 1 to 4 substituents each of which is independently halogen, CN, C1-6 alkyl, OH, oxo, O—C1-6 alkyl, C1-6 haloalkyl, O—C1-6 haloalkyl, C(O)N(RA)RB, C(O)RA, CO2RA, or SO2RA;
each J is independently:
(i) O,
(ii) S,
(iii) S(O),
(iv) S(O)2,
(v) O—C1-6 alkylene,
(vi) S—C1-6 alkylene,
(vii) S(O)—C1-6 alkylene,
(viii) S(O)2—C1-6 alkylene,
(ix) N(RA), or
(x) N(RA)—C1-6 alkylene;
each RA, RB, RC and RD are independently selected from H, C1-6 alkyl and C3-6cycloalkyl, wherein said C1-6 alkyl and C3-6 cycloalkyl are optionally substituted with one or more substituents up to the maximum number allowed by valence selected from the group consisting of: halogen, OH, CN, C1-4 alkoxy, C3-6cycloalkyl and phenyl;
or alternatively each pair of RC and RD together with the nitrogen to which they are both attached form a 4- to 7-membered saturated or mono-unsaturated ring which optionally contains a heteroatom in addition to the N to which RC and RD are attached, wherein the additional heteroatom is selected from N, O, and S; wherein the ring is optionally substituted with 1 or 2 substituents each of which is independently C1-6 alkyl, C(O)RA, C(O)ORA, C(O)N(RA)RB, or S(O)2RA; and wherein the optional S in the ring is optionally in the form of S(O) or S(O)2
each aryl is independently (i) phenyl, (ii) a 9- or 10-membered bicyclic, fused carbocylic ring system in which at least one ring is aromatic, or (iii) an 11- to 14-membered tricyclic, fused carbocyclic ring system in which at least one ring is aromatic;
each heterocyclyl is independently (i) a 4- to 8-membered, saturated or unsaturated monocyclic ring, (ii) a 7- to 12-membered bicyclic ring system, or (iii) a 10- to 18-membered tricyclic ring system, wherein each ring in (ii) or (iii) is independent of, fused to, or bridged with the other ring or rings and each ring is saturated or unsaturated; wherein the monocyclic ring contains from 1 to 4 heteroatoms and a balance of carbon atoms; the bicyclic ring system or tricyclic ring system contains from 1 to 8 heteroatoms and a balance of carbon atoms, wherein one or more of the rings contain one or more of the heteroatoms; wherein the heteroatoms are selected from N, O and S; and wherein any one or more of the nitrogen and sulfur heteroatoms is optionally oxidized, and any one or more of the nitrogen heteroatoms is optionally quaternized;
each heteroaryl is independently (i) a 5- or 6-membered heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein each N is optionally in the form of an oxide, or (ii) a 9- or 10-membered heterobicyclic, fused ring system containing from 1 to 4 heteroatoms independently selected from N, O and S, wherein either one or both of the rings contain one or more of the heteroatoms, at least one ring is aromatic, each N is optionally in the form of an oxide, and each S in a ring which is not aromatic is optionally S(O) or S(O)2.

US Pat. No. 10,189,824

PYRIMIDINE-DIAMINE DUAL HSP90/TRAP1 INHIBITORS

Calasia Pharmaceuticals, ...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
R1 is hydrogen, halo, (C1-C3)alkyl, halo(C1-C3)alkyl, (C1-C3)alkoxy, or halo(C1-C3)alkoxy;
R3, R4, and R5 are independently hydrogen, halo, (C1-C3)alkyl, halo (C1-C3)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, cyano,
R2 is heteroaryl or heterocycyl, each of which are optionally substituted with 1 to 2 groups independently selected from R6, but not 4-morpholinyl or benzo[d][1,3]dioxol-5-yl;p is 0, 1, or 2;
R6 is selected from halo, cyano, nitro, amino, hydroxy, carboxy, (C1-C6)alkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroalkyl, heterocyclylalkyl, hydroxy(C1-C6)alkyl, CO2H, (CH2)1-3COOH, (C1-C3)alkylcarbonyloxy, (C3-C6)cycloalkyl, hydroxy(C3-C6)cycloalkyl, (C4-C7)cycloalkylalkyl, (C2-C6)alkenyl, halo(C2-C6)alkenyl, hydroxy(C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl(C2-C4)alkynyl, halo(C1-C6)alkyl, halo(C3-C6)cycloalkyl, halo(C4-C7)cycloalkylalkyl, (C1-C6)alkoxy, (C3-C6)cycloalkoxy, (C4-C7)cycloalkylalkoxy, halo(C1-C6)alkoxy, halo(C3-C6)cycloalkoxy, halo(C4-C7)cycloalkylalkoxy, (C1-C6)alkylthio, (C3-C6)cycloalkythio, (C4-C7)cycloalkylalkylthio, halo(C1-C6)alkylthio, halo(C3-C6)cycloalkythio, halo(C4-C7)cycloalkylalkylthio, (C1-C6)alkylsulfinyl, (C3-C6)cycloalkylsulfinyl, (C4-C7)cycloalkylalkylsulfinyl, halo(C1-C6)alkylsulfonyl, halo(C3-C6)cycloalkylsulfinyl, halo(C4-C7)cycloalkylalkylsulfinyl, (C1-C6)alkylsulfonyl, (C3-C6)cycloalkylsulfonyl, (C4-C7)cycloalkylalkylsulfonyl, halo(C3-C6)cycloalkylsulfonyl, halo(C4-C7)cycloalkylalkylsulfonyl, (C1-C6)alkylamino, di(C1-C6)alkylamino, (C1-C6)alkoxy(C1-C6)alkoxy, halo(C1-C6)alkoxy(C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, H2NCO, H2NSO2, (C1-C6)alkylaminocarbonyl, di(C1-C6)alkylaminocarbonyl, (C1-C3)alkoxy(C1-C3)alkylaminocarbonyl, heterocyclylcarbonyl, (C1-C6)alkylaminosulfonyl, di(C1-C6)alkylaminosulfonyl, heterocyclylsulfonyl, (C1-C6)alkylcarbonylamino, (C1-C6)alkyl-carbonylamino(C1-C6)alkyl, (C1-C6)alkylsulfonylamino, (C1-C6)alkylsulfonylamino(C1-C6)alkyl, (C1-C6)alkoxycarbonyl(C1-C6)alkoxy, (C1-C6)alkoxy(C1-C6)alkyl, halo(C1-C6)alkoxy(C1-C6)alkyl, hydroxy(C1-C6)alkoxy, oxo, amino(C1-C6)alkyl, (C1-C6)alkylamino(C1-C6)alkyl, di(C1-C6)alkylamino(C1-C6)alkyl amino(C2-C6)alkoxy, (C1-C6)alkylamino(C2-C6)alkoxy, di(C1-C6)alkylamino(C2-C6)alkoxy, (C1-C6)alkylcarbonyl, hydroxy(C1-C6)alkylcarbonyl, (C1-C6)alkylhydroxycarbonyl, (C1-C6)alkylhydroxy(C1-C6)alkyl, (C3-C6)cycloalkylcarbonyl, (C3-C6)cycloalkylaminocarbonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl, di(C3-C6)cycloalkylaminocarbonyl, (C3-C6)cycloalkylaminosulfonyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminosulfonyl, di(C3-C6)cycloalkylaminosulfonyl, cyano(C1-C6)alkyl, aminocarbonyl(C1-C6)alkyl, (C1-C6)alkylaminocarbonyl(C1-C6)alkyl, di(C1-C6)alkylaminocarbonyl(C1-C6)alkyl, (C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl, {(C3-C6)cycloalkyl}{(C1-C6)alkyl}aminocarbonyl(C1-C6)alkyl, [(C1-C6)alkyl(C4-C6)heterocyclyl](C1-C6)alkyl, and di(C3-C6)cycloalkylaminocarbonyl(C1-C6)alkyl;
R7 and R8 are independently hydrogen or alkyl; and
R9 is H or alkyl.

US Pat. No. 10,189,819

FACTOR IXA INHIBITORS

Mochida Paraceuticals Co....

1. A compound of Formula I:
wherein A is selected from:

R1 is phenyl, which is optionally substituted with halo, R5, (C?O)OR5, (C?O)NR5R6 or C1-3 alkyl(C?O)OR5; or heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, R5, OR5, NR5R6 and C1-3 alkyl-NR5R6;
R2 is hydrogen or C1-6 alkyl;
R3 is heteroaryl, which is optionally substituted with one or two substituents independently selected from the group consisting of halo, oxo, cyclopropyl, R5, OR5, (C?O)OR5 and CH2SO2CH3;
each R4 is independently selected from halo, R5 or OR5,
each R5 is hydrogen or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
R6 is hydrogen, cyclopropyl or C1-6 alkyl, which is optionally substituted with one to three substituents independently selected from the group consisting of halo and hydroxy;
Ra is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rb is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rc is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rd is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Re is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rf is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rg is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
Rh is hydrogen, halo, C1-6 alkyl or O(C1-6 alkyl);
n is an integer between zero and two;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,798

ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM

MEDICAL TECHNOLOGY RESEAR...

1. An antimicrobial silver s-triazine compound consisting of:silver with an s-triazine ring carrying at least one substituent R and/or R1 on a nitrogen atom;
wherein R and/or R1 is not hydrogen;
wherein the antimicrobial silver s-triazine compound has one of the following chemical structures:

wherein, for structure (iv), R and R1 include one of the group consisting of a straight chain alkyl group of 1 to 20 carbon atoms, a branched alkyl group of 0.1 to 20 carbon atoms, an allyl group, a vinyl group, a napthyl group, and a heteroaryl group when R and R1 are different;
wherein, for structure (iv), R and R1 include one of the group consisting of the straight chain alkyl group of 1 to 20 carbon atoms, the branched alkyl group of 1 to 20 carbon atoms, and the napthyl group when R and R1 are identical; and
wherein, for structure (i), R includes one of the group consisting of the straight chain alkyl group of 1 to 20 carbon atoms, the branched alkyl group of 1 to 20 carbon atoms, the allyl group, the vinyl group, a phenyl group, a benzyl group, the napthyl group, and the heteroaryl group.

US Pat. No. 10,189,731

UNDERGROUND SEPTIC TANK

Pallette Stone Corporatio...

1. An underground septic tank comprising:a substantially liquid impermeable, cylindrical plastic vessel having a top, a bottom, sides, and a substantially horizontal longitudinal axis;
a concrete container encasing and retaining the cylindrical plastic vessel, the concrete container contacting the bottom and at least partially contacting the sides of the cylindrical plastic vessel; and
at least one opening for receiving waste effluent into the cylindrical plastic vessel;
wherein the septic tank is adapted to withstand vehicle loading.

US Pat. No. 10,189,720

WATER PURIFYING CARTRIDGE AND PITCHER-TYPE WATER PURIFIER

Mitsubishi Rayon Cleansui...

1. A water purifying cartridge, comprising:a water purification material for treating water to be treated;
a housing body in which the water purification material is directly received, a discharge hole discharging purified water is formed at a bottom, and a top end is opened;
a plate-shaped housing lid provided at the top end of the housing body, and
a film filtration water purification unit and an adsorption water purification unit,
wherein the adsorption water purification unit is disposed at an upstream side of the film filtration water purification unit, and the adsorption water purification unit is configured by an adsorbing material that is directly filled in the housing body, and
wherein the film filtration water purification unit is a hollow fiber film water purification unit.

US Pat. No. 10,189,696

BOTTLED BAG FLUID DISPENSER

Utrem Innovation, LLC, H...

1. An apparatus for dispensing a beverage comprising:a bottle;
a bladder for containing the beverage; and
a spigot for dispensing the beverage, wherein the spigot comprises:
one or more air ports, wherein each air port comprises a cutout on a wall of the spigot, wherein the one or more air ports are configured to maintain atmospheric pressure inside the bottle; and
one or more vertical ridged elements, wherein the bladder is sealed to a base portion of the spigot, and wherein the one or more ridged elements are configured to create an air gap between the spigot and the bottle to allow air to flow into a body of the bottle.

US Pat. No. 10,189,690

VEHICLE LIFT

Marta Fiorese, Albignase...

1. A vehicle lift including a vehicle support plane (1), a base plate (50), and a lifting/lowering mechanism (101) disposed between said vehicle support plane and said base plate, said lifting/lowering mechanism comprising:two pair of levers (2,3) each arranged laterally supporting said vehicle support plane, the levers (2,3) of each pair being articulated to one another scissor like in an intermediate section (4) defining parallel inner levers (2,2) and parallel outer levers (3,3), the inner levers of each pair each having a first end hingedly connected said vehicle support plane and each having a second end adapted to slide longitudinally on said base plate, the outer levers of each pair each having a first end adapted to slide longitudinally on an underside of said vehicle support plane and each having a second end hingedly connected to said base plate;
an articulated system (10) interconnecting the inner levers of the two pair of levers and including a rocker arm (11) comprising two lateral side wall elements (12) each hingedly connected at an intermediate axis (14) to a respective inner lever of said tow pair of levers, a first roller (20) rotatably supported on an axle pin (22) interconnecting said lateral side wall elements at a first end of said rocker arm, a second roller (21) rotatably supported on an axle pin (23) interconnecting said lateral side wall elements at a second end of said rocker arm, in a collapsed condition of said vehicle lift said first roller (20) engaging for rotation thereon a first inclined plane (30) and said second roller (21) engaging for rotation thereon a second inclined plane (31), said first and second inclined planes being upwardly converging; and
a fluid-dynamic actuator (9) articulated at a first end to a member interconnecting the second ends of the outer levers of the two pair of levers and operatively connected at a second end to said axle pin at the first end of said rocker arm of said articulated system,
whereby upon commencement of lifting and opening the vehicle lift, the fluid-dynamic actuator (9) acts on the articulated system (10) imparting a thrust to the axle pin at the first end of the rocker arm (11) causing the first roller (20) to move upwardly on the respective inclined plane (30) and as a result of the rocker action of the rocker arm (11) an upward movement is imparted to the intermediate axis (14) connecting the rocker arm (11) to the inner levers of the two pair of levers (2,3) resulting in upward movement of the inner levers and commencement of lifting and opening of the vehicle lift and simultaneously the second roller (21) is moved upwardly on the second inclined plane (31).

US Pat. No. 10,189,677

ELEVATOR CONTROL SYSTEM WITH FACIAL RECOGNITION AND AUTHORIZED FLOOR DESTINATION VERIFICATION

Edward A. Bryant, Maplew...

1. A method for controlling an elevator car using facial recognition, comprising the steps of:providing at least one elevator car, the at least one elevator car controlled by an elevator control system;
providing a facial image database comprising facial image data of authorized passengers and corresponding authorized floor destination data for each such passenger;
providing a facial recognition program capable of comparing a facial image stored in the facial image database to video data output from a first imaging device, the facial recognition program in communication with the elevator control system;
providing a first imaging device capable of outputting video data;
detecting an elevator passenger's upturned head and recognizing a facial image of the elevator passenger's face in a field of view of the first imaging device;
capturing the elevator passenger's facial image using video data output from the first imaging device;
comparing the captured facial image to the facial image data;
determining a match between the captured facial image and a facial image stored in the facial image database;
sending a signal to the elevator control system to call the at least one elevator car in a preferred up/down direction; and
sending a signal to the elevator control system to move the at least one elevator car to the elevator passenger's authorized floor destination.

US Pat. No. 10,189,567

IDENTIFYING CAMERA POSITION OF A UAV IN FLIGHT UTILIZING REAL TIME KINEMATIC SATELLITE NAVIGATION

SKYCATCH, INC., San Fran...

1. A method comprising:determining, by at least one processor during a flight mission of a UAV, a position of the UAV at a first time and a position of the UAV at a second time based on a number of wave lengths of a signal transmitted from a satellite to the UAV at the first time, a number of wave lengths of the signal at the second time, RTK correction data at the first time, and RTK correction data at the second time;
identifying, by the at least one processor during the flight mission, a time that a camera affixed to the UAV captures a digital aerial image of a site by detecting when a shutter of the camera affixed to the UAV is open;
detecting an attitude of the UAV at the time that the camera affixed to the UAV captures the digital aerial image, wherein the attitude comprises a measurement of pitch, roll, and yaw of the UAV corresponding to the time that the camera affixed to the UAV captures the digital aerial image; and
determining, by the at least one processor, a position of the camera based on a time of capturing the digital aerial image, the attitude of the UAV at the time that the camera affixed to the UAV captures the digital aerial image, the position of the UAV at the first time, and the position of the UAV at the second time;
determining, by the at least one processor during the flight mission, a quality of a calculation of the position of the UAV at a third time, wherein determining the quality of the calculation comprises determining whether the calculation is fixed or floating; and
modifying flight of the UAV based on the determination of the quality of the calculation.

US Pat. No. 10,189,546

EMERGENCY SHIP ARREST SYSTEM AND METHOD

ALASKA MARITIME PREVENTIO...

1. An emergency ship arrest system comprising:a vessel attachment system configured to operatively connect to a disabled vessel at sea, the vessel attachment system including a bridle system and a hawser assembly having a hawser line, wherein a proximal end of the hawser line is operatively connected to the bridle system, and wherein the bridle system is configured to engage at least four fittings on a foredeck of the disabled vessel to distribute a load applied to the hawser line over the at least four fittings on the foredeck;
a retrieving system detachably connected to the vessel attachment system in a setup position, the retrieving system including a retrieving line, wherein a proximal end of the retrieving line is detachably connected to a distal end of the hawser line in the setup position; and
a para sea anchor system detachably connected to the vessel attachment system in an anchor position, the para sea anchor system including a main rode and a para sea anchor having a canopy and a plurality of shrouds, wherein a proximal end of the main rode is detachably connected to the distal end of the hawser line in the anchor position, wherein each of the plurality of shrouds of the para sea anchor interconnects a distal end of the main rode and a perimeter of the canopy.

US Pat. No. 10,189,488

RAILWAY FREIGHT CAR DRAFT GEAR ASSEMBLY

AMSTED RAIL COMPANY, INC....

1. A draft gear assembly for use with railway freight cars, the draft gear assembly having a front end and a back end and comprising:a draft sill;
a yoke having a rear wall and being shiftable relative to the draft sill between a buff position, a neutral position, and a draft position,
a front draft gear adjacent a butt end of a coupler shank, the front draft gear including a front follower, a back follower, and a front resilient member therebetween;
a back draft gear adjacent the rear wall of the yoke, the back draft gear including a front follower, a back follower, and a back resilient member therebetween,
an intermediate stop member between the front draft gear and the back draft gear,
a yoke intermediate stop of the yoke between the front draft gear and the back draft gear, the yoke intermediate stop being shiftable relative to the intermediate stop member with shifting of the yoke between the buff position, neutral position, and draft position;
the front resilient member and the back resilient member being compressible,
the draft sill having front stops, the front draft gear including a front stop surface for contact with the draft sill front stops,
the draft sill having rear stops, the back draft gear including a back stop surface for contact with the draft sill rear stops,
the front draft gear including a back stop surface contacting the yoke intermediate stop with the yoke in the neutral position, and
the back draft gear including a front stop surface contacting the yoke intermediate stop with the yoke in the neutral position.

US Pat. No. 10,189,486

RAILCAR WITH NESTED SLIDING GATES

Trinity North American Fr...

1. A railcar system comprising:a railcar; and
a nested sliding gate assembly disposed within the railcar, and comprising:
an upper deck comprising a plurality of holes;
a lower deck positioned below the upper deck, and comprising a plurality of discharge ports; and
a driving system operably coupled to the lower deck, wherein:
the driving system is configured to position the lower deck in a first position with respect to the upper deck,
the holes of the upper deck and the discharge ports of the lower deck do not align when the lower deck is in the first position,
the driving system is configured to position the lower deck in a second position with respect to the upper deck, and
the holes of the upper deck and the discharge ports of the lower deck at least partially align when the lower deck is in the second position.

US Pat. No. 10,189,476

BRAKE FORCE DISTRIBUTION

Zoox, Inc., Foster City,...

1. A vehicle operable to travel in at least a first direction, the vehicle comprising:two or more wheel assemblies;
a power system operable to provide power to enable the vehicle to accelerate;
a brake system operable to cause, responsive to a braking action, a first negative force to be distributed between the two or more wheel assemblies to cause the vehicle to decelerate; and
a control system comprising:
one or more processors; and
one or more instructions executable by the one or more processors to send a command, responsive to the braking action, to at least one of the power system or the brake system to:
cause the power system to affect a second negative force on a first wheel assembly of the two or more wheel assemblies at a first time; and
cause the power system to affect a positive force on a second wheel assembly of the two or more wheel assemblies at a second time that is substantially a same time as the first time,
wherein an application of the second negative force and the positive force generates a brake force distribution such that a first total amount of braking force applied at the first wheel assembly is greater than a second total amount of braking force applied at the second wheel assembly.

US Pat. No. 10,189,439

SEAT BELT RETRACTOR AND SEAT BELT DEVICE

JOYSOFT SAFETY SYSTEMS JA...

1. A seat belt retractor provided with a spool configured to perform winding of a webbing for restraining an occupant, a shaft inserted through an axial center of the spool, and a locking base connected to the shaft and capable of switching between a rotating state and a non-rotating state, the seat belt retractor comprising:a load adjustment member disposed between the shaft and the locking base and configured to block or reduce load transmission in a case where a load equal to or greater than a threshold is applied to the shaft; and
an energy absorption device disposed between the spool and the locking base and capable of changing an energy absorption amount according to a relative rotation speed between the spool and the locking base, wherein the energy absorption device is connected in parallel with the load adjustment member, and wherein the energy absorption device includes a housing coaxially disposed on a spool side, a clutch plate coaxially disposed on a locking base side, and a drag generation member housed inside the housing and configured to generate drag according to a relative rotation speed between the housing and the clutch plate, and
wherein
the housing has a pair of facing planes facing a front surface and a back surface of the clutch plate, wherein annular corrugated grooves are formed on the pair of facing planes such that projections and recesses thereof are synchronous with each other,
the drag generation member includes a plurality of driving pins having both ends thereof inserted into the corrugated grooves, and
the clutch plate has a plurality of openings through which the plurality of driving pins is inserted so as to be capable of moving along the corrugated grooves.

US Pat. No. 10,189,381

SAFETY BELT ASSEMBLING DEVICE CAPABLE OF ASSEMBLING A CHILD RESTRAINT SYSTEM WITH A VEHICLE SEAT

Wonderland Switzerland AG...

1. A safety belt assembling device capable of assembling a child restraint system with a vehicle seat, the safety belt assembling device comprising:a child restraint connected with the child restraint system, the child restraint having a sunken structure;
a panel rotatably disposed on the child restraint and adapted to press a safety belt of the vehicle seat inside the sunken structure; and
a fastener mechanism, comprising:
a locking rod disposed inside the sunken structure;
at least one latching hook rotatably disposed on the panel and utilized to detachably catch on the locking rod; and
a releasing actuator rotatably disposed on the panel and connected with the latching hook, the releasing actuator being rotated from a flush position to a protruding position to disengage the latching hook from the locking rod.

US Pat. No. 10,189,244

METHOD FOR SELECTING A FORMAT FOR A SECTION TO BE PRINTED

Hewlett-Packard Gesellsch...

1. A method for producing a print product including selecting a print section format for a section to be printed having at least one signature, the steps comprising:selecting, by a processor, a print section layout that divides the section to be printed in a running direction and in a transversal direction into adjacent units;
assigning the at least one signature which includes pages in a page format of the print product to a unit of the adjacent units;
determining border regions outside of the at least one signature, longitudinal dimensions in a running direction of the at least one signature, and transversal dimensions in a transversal direction of the at least one signature, wherein at least one of the border regions adjoins an adjacent border region for an adjacent page;
implementing a fold-over outside of at least one of the border regions;
calculating an optimal longitudinal dimension from the sums of the longitudinal dimensions and the border regions adjoining in the running direction, the fold-over outside of at least one of the border regions in the running direction, and a percentage of a difference between a longitudinal dimension and a minimum longitudinal dimension;
calculating an optimal transversal dimension from the sums of the transversal dimensions and the border regions adjoining in the transversal direction, and a percentage of a difference between a transversal dimension and a minimum transversal dimension; and
selecting the print section format so that the longitudinal dimension of the print section format is at least equal to the optimal longitudinal dimension and the transversal dimension of the print section format is at least equal to the optimal transversal dimension;
imprinting the section to be printed;
collating the at least one signature for the imprinted section; and
cutting the imprinted and collated section into page format to form the print product.

US Pat. No. 10,189,221

TRANSFER RING SHOE AND TRANSFER RING HAVING VARIED SHOE PROFILE

Davian Enterprises, LLC, ...

1. A transfer ring comprising:a circular frame;
a plurality of elongated driven links, each driven link having a first end rotatably mounted along the circular frame such that each driven link is rotatable between a contracted position and an expanded position;
a drive member disposed along the circular frame, the drive member being in operable engagement with the driven links and configured to drive the driven links between the contracted position and the expanded position; and
a plurality of shoes having arcuate interior surfaces facing substantially radially inwardly toward a central axis to collectively define a substantially cylindrical segmented gripping surface, each shoe being rotatably mounted to a second end of a respective one of the driven links, each shoe arcuate interior surface having a first arcuate edge and an opposite second arcuate edge extending substantially parallel to one another along a circumferential dimension of the cylindrical segmented gripping surface and opposite first and second end edges extending between respective ends of the first and second arcuate edges;
wherein the first end edge of the arcuate interior surface of each shoe is mounted adjacent the second end edge of the arcuate interior surface of a respective adjacent one of the shoes, and wherein the first end edge of the arcuate interior surface of a first one of the shoes defines a first profile shape, in the form of a plurality of alternating protrusions and recesses along the circumferential dimension, which is keyed to mating engagement with a shape of the second end edge of the arcuate interior surface of a second one of the shoes adjacent to the first one of the shoes, the remaining first and second end edges conforming to a second profile shape which is a substantially straight line extending substantially parallel to an axial dimension of the cylindrical segmented gripping surface.

US Pat. No. 10,189,183

METHOD AND APPARATUS ARRANGEMENT FOR MIXING SILICONE COMPOSITION

Oy Pro-Hydro Ab, Tornio ...

1. A method for manufacturing a silicone composition, in which methoda pumping of different silicone composition subcomponents is started;
the silicone composition subcomponents are pumped with component-specific pumps to a mixer of silicone composition subcomponents;
a silicone composition is mixed from the subcomponents with the mixer;
the process for manufacturing silicone composition is stopped due to downtime;
wherein
the silicone composition mixer is cooled to a temperature, in which a chemical reaction between the different subcomponents of the silicone composition stops;
the silicone composition mixer is kept at the cooling temperature for a duration of the downtime; and that
the manufacture of the silicone composition is continued after the downtime without cleaning the mixer.

US Pat. No. 10,189,176

AUTOMATED APPARATUS FOR CONSTRUCTING ASSEMBLIES OF BUILDING COMPONENTS

Williams Robotics, LLC, ...

1. A system for constructing wall panels comprising a plurality of structural members, the system comprising:a source of structural members of predetermined size;
a horizontal table configured to support structural members as the structural members are being formed into a wall panel, the table including a stationary section and a movable carriage that is configured to move in a longitudinal direction toward and away from the stationary section;
an articulated arm unit having a gripper, the articulating arm unit positioned to retrieve structural members from the source with the gripper and place them on the table;
at least one first clamping unit fixedly mounted to the stationary section for clamping structural members thereto;
at least one second clamping unit fixedly mounted to the movable carriage for clamping structural members thereto; and
a controller that controls the movement of the articulating arm unit and the movable carriage.

US Pat. No. 10,189,166

SUCTION EQUIPMENT

HARMOTEC CO., LTD., Kofu...

1. Suction equipment comprising:a columnar main body;
a flat end face formed at the main body;
a concave part formed at the end face;
a fluid flow-forming means for forming a fluid swirl flow in the concave part or forming a radial flow by discharging fluid into the concave part, the fluid swirl flow or the radial flow generating negative pressure that applies suction to a member;
a baffle plate including a hole formed at a center of the baffle plate such that the hole opens toward the member, the hole allowing the fluid, to which suction has been applied due to the negative pressure, to pass through and prevent the member from entering the concave part; and
at least one support member supporting the baffle plate so that the baffle plate opposes the concave part, the at least one support member forming a flow path for the fluid to flow out of the concave part between the end face and the baffle plate.

US Pat. No. 10,189,155

TOOL COUPLING ARRANGEMENT

The Ames Companies, Inc.,...

1. A coupling for an elongated handle and a tool head, the tool head having a tool head shank supporting tool body, the tool head shank having an opening extending through the tool head shank, the coupling comprising:a plug member;
a ferrule; and
a pin member,
wherein the plug member further comprises an elongated passage formed therein that is configured to receive the tool head shank, the elongated passage being in communication with a pair of aligned mount grooves;
wherein the plug member is partially received within the ferrule, and
wherein the pin member is configured to extend through the opening of the tool shank and seated within the aligned mount grooves of the plug member when the tool head shank is mounted in the channel to secure the tool head shank to the plug member and ferrule.

US Pat. No. 10,189,130

MACHINE TOOL

DMG MORI CO., LTD., Yama...

1. A machine tool having a tool changer, comprising:a tool holding part holding a plurality of tools; and
a tool change mechanism changing a tool held by the tool holding part and a tool clamped by a spindle,
wherein the tool holding part is positioned in a side of the spindle to hold the plurality of tools in a manner in which axes of the tools are parallel to an axis of the spindle,
the tool change mechanism includes a circular arc movement mechanism,
the circular arc movement mechanism moves the tools from a tool holding position to a tool change position at which the tool is coaxial with the axis of the spindle, by at least a circular arc movement on a plane on which the axis of the spindle positioned in the tool change position and an axis of the tool positioned in the tool holding part are arranged,
the tool position is different for each of the tools,
a dividing wall is formed between the tool change mechanism and the spindle,
the dividing wall includes an opening which is closed by a shutter, and
the circular arc movement mechanism moves the tools in the circular arc movement through the opening when the shutter opens the opening.

US Pat. No. 10,189,117

ADHESION IMPROVEMENT VIA MATERIAL NANOSTRUCTURING OR TEXTURIZING

The United States of Amer...

1. A method of treating a material surface comprising:selecting a material of interest to be processed comprising a target surface of interest;
determining a surface adhesion transformation of said target surface of interest based on said material's properties, a shape of said target surface of interest, an adhesion material, and required degree of adhesion between said target surface of interest and another object's surface, wherein said material's properties comprise mechanical or chemical interfacial material properties required after application of said method;
providing an at least one ultra-short pulse laser system (USPL), a rastering system adapted for controlling rastering of laser energy output of said USPL over said target surface of interest based on said determined surface adhesion transformation of said target surface of interest, and an environmental system to control environmental conditions around said target surface of interest comprising one or more target adhered surfaces to be modified, wherein said surface adhesion transformation comprises a transformation of said target surface of interest to a first depth resulting in an increase of porosity or texture of said target surface of interest which alters chemical bonding properties and adhesion properties of the target surface of interest;
configuring said USPL by adapting said laser energy output so said USPL is operable to convert a portion of said target surface of interest's material up to a second depth into a plasma state during application of said laser energy output, said configuring of said USPL by programming said USPL comprises a configuration so said USPL is operable to a pre-determined irradiance, pulse duration of femtoseconds (fs) to restructure said target surface of interest, and pulse frequency, laser wavelength, and laser polarization based on said determined surface adhesion transformation so said USPL is operable to create nano-structures on said target surface of interest during application of said laser energy output to produce a resultant processed region having a surface covered by pre-determined nano structure formations which alter the resultant processed region to increase surface area and thereby increase adhesion properties of said surface of the processed region;
configuring said system adapted for rastering said laser energy output over said target surface of interest to apply said laser energy output in a pre-determined rasterization pattern and laser angle to said target surface of interest during application of said laser energy output; and
applying said laser energy output based on said programming, said determined surface level of adhesion, and said adapting of said laser energy output thereby exposing said target surface of interest wherein a laser beam of said USPL is rastered across said target surface of interest, adjusting one or more positions of said laser beam relative to said target surface of interest by a width of a functional beam diameter of said laser beam with each pass of the USPL.

US Pat. No. 10,189,109

PURGE DAM AND METHOD OF USE

DOCKWEILER AG, Neustadt-...

1. A purge dam assembly for confining a volume within an assembly of pipes, including a distal pipe and a proximal pipe together arranged for butt welding at a seam, comprises:a distal disk, the distal disk being covered at its periphery with a distal sock, the sock being a tubular pipe comprising a gasketing material, the gasketing material consisting of a synthetic textile, the synthetic textile comprising 100% continuous filament polyester, the filament being sufficiently soft to contact an electropolished stainless steel surface without significantly scratching that surface, the distal disk being sized such that the distal sock contacts but does not completely seal against an inner surface of the distal pipe permitting a purging flow of purge gas from the volume and past the distal disk when the purge disk assembly is inserted into the assembly of tubes or pipes;
a proximal disk, the proximal disk being covered at its periphery with a proximal sock comprising the gasketing material, the proximal disk defining a purge gas portal for admitting of a purging flow of purge gas into the volume and, further, being sized such that the proximal sock contacts but does not completely seal against an inner surface of the proximal pipe permitting a purging flow of purge gas from the volume and past the distal disk; and
a cross-member having a proximal and a distal end, the proximal end being affixed to the proximal disk and the distal end being affixed to the distal disk in a manner to preserve the spatial separation between the proximal disk and distal disk and to maintain the proximal and distal disks in coaxial alignment.

US Pat. No. 10,189,104

ROTATABLE ELECTRIC HEATING TOOL

Goodhouse Enterprise Co. ...

1. An electric heating tool comprising:a handle device including a body, a power connection member, and a sleeve, with the body including a protrusion having an inner edge, with the power connection member received in the inner edge of the protrusion and including a first electrode, a second electrode, a first extending portion, and a second extending portion, with the first electrode electrically connected to the first extending portion, with the second electrode electrically connected to the second extending portion, with the sleeve mounted around the protrusion, with the sleeve including a guiding recess located at an inner periphery thereof; and
a heating device rotatably mounted to the handle device and including a seat, a heating member, and a third electrode, with the seat including a guiding portion rotatably engaged in the guiding recess of the sleeve, with the heating member mounted to the seat, with the third electrode mounted to the seat and electrically connected to the heating member, with the third electrode slidely and electrically connected to the first electrode of the power connection member, and with the heating member slidely and electrically connected to the second electrode of the power connection member.

US Pat. No. 10,189,071

METHOD FOR SUPERPLASTIC FORMING A MULTILAYER STRUCTURE HAVING A MONOLITHIC ATTACHMENT MEMBER

The Boeing Company, Chic...

1. A method for forming a multilayer structure from a precursor panel having an edge, said method comprising:connecting an attachment member to said precursor panel such that an edge of said attachment member is in alignment with said edge of said precursor panel; and
applying heat and gas pressure to expand said precursor panel.

US Pat. No. 10,189,068

BENDING PRESS

BYSTRONIC LASER AG, Nied...

1. A bending press comprising:an upper tool;
a first tool holder configured to hold said upper tool;
a lower tool;
a second tool holder configured to hold said lower tool;
a workpiece-positioning stop movably mounted relative to said upper and lower tools;
a drive operatively connected to said workpiece-positioning stop to controllably position said workpiece-positioning stop relative to said tools;
a sensor configured to detect, respectively for each of said upper and lower tools, at least one respective tool parameter selected from the group of tool parameters consisting of tool position and tool type; and,
a controller in operative communication with said drive, said controller being in operative communication with said sensor to receive therefrom, respectively for each of said upper and lower tools, detected respective values of the at least one tool parameter, said controller having electronic circuitry and programmed instructions that control said drive to controllably position said workpiece-positioning stop relative to said upper and lower tools depending on at least one detected respective value of the at least one tool parameter respectively for each of said upper and lower tools.

US Pat. No. 10,189,052

METHODS OF DRIVING POLARIZATION INVERSION IN FERROELECTRIC MATERIALS AND DEVICES

THUNDER BAY REGIONAL HEAL...

1. A method of electrically driving a ferroelectric material to achieve polarization inversion, the ferroelectric material having an anisotropic potential energy surface with an energy barrier for a curved switching path that is lower than for the barrier for a direct path associated with uniaxial switching, the method comprising:applying time-dependent voltages to the ferroelectric material in at least two directions; and
controlling the voltages such that the orientation of the electric field within the ferroelectric material varies with time during the switching cycle, such that the coercive field is reduced relative to the coercive field required for uniaxial excitation;
wherein the voltages are applied such that the coercive field is exceeded during the switching cycle, thereby achieving polarization inversion.

US Pat. No. 10,189,039

DEVICE FOR PACKAGING AND DISPENSING FLUID, LIQUID OR PASTY PRODUCTS

LABLABO, Juvigny (FR)

1. Device for dispensing fluid products comprising;an extension tip connected by a first end to a nozzle associated with a metering pump mounted on a bottle containing the product that is to be dispensed and having at its distal second end a discharge orifice, said extension tip bearing a shutter a first end of which is arranged on said discharge orifice, this shutter configured to open at its distal second end under the pressure of the product when said pump is actuated, and said shutter having a tubular external part, elastically deformable in longitudinal bending, of which a first end is arranged on the discharge orifice and of which the tapering external cross section diminishes evenly towards its distal second end, at least over part of its length, said external part being intended to deform elastically in a radial direction at its distal second end under the pressure of the fluid leaving the pump via said nozzle,
wherein said shutter has, inside said external part, a tubular connector secured to said discharge orifice of the tip and a stem of cross section substantially equal to the internal cross section of the distal second end of said external part, which is connected by its first end to this connector by means of an articulation and which via its second end closes the distal second end of said external part.

US Pat. No. 10,189,038

INDUCTIVELY HEATABLE FLUID RESERVOIR FOR VARIOUS FLUID TYPES

Toaster Labs, Inc., Seat...

1. A fluid delivery pod comprising:a first surface;
a second surface that opposes the first surface;
a reservoir body intermediate the first and the second surfaces, wherein the reservoir body is configured to house a fluid;
an outlet port in fluid communication with the reservoir;
a heating structure within the reservoir body and being electrically conductive to wirelessly receive inductive energy from an energy source that is external to the fluid reservoir to heat at least a portion of the fluid within the reservoir body; and
a valve assembly that is operative to, in response to an application of compression forces on the opposing first and the second surfaces, dispense at least a portion of the heated fluid through the outlet port;
wherein the first surface further comprises a piston that translates along at least a portion of the reservoir body.

US Pat. No. 10,189,033

DEPOSITION OF COATINGS ON SUBSTRATES

Laser Fusion Technologies...

1. A coating process for the deposition of a layer of a first material onto a substrate of a second material, the second material optionally being different from the first material, the process including the steps:entraining powder particles of the first material into a carrier gas flow to form a powder beam directed to impinge on the substrate, thereby defining a powder beam footprint region at the substrate;
causing relative movement of the powder beam and the substrate in a movement direction to move the powder beam footprint relative to the substrate to deposit the layer of the first material; and
operating a laser source to direct a laser beam along a laser beam principal axis direction to provide a laser beam footprint to cause direct, local heating of at least one of the forward substrate region and the powder beam footprint region, without macroscopic melting of the first material,the laser beam principal axis direction being defined with reference to a plane coincident with or tangential to a surface of the substrate at the centre of the laser beam footprint in terms of an elevation angle from the plane to the laser beam principal axis direction and in terms of an acute azimuthal angle from the movement direction to the laser beam principal axis direction, wherein the elevation angle is 80° or less and the azimuthal angle is ±60° or less.

US Pat. No. 10,189,018

METHOD AND APPARATUS FOR DISPENSING PRECISE ALIQUOTS OF LIQUID

VISTALAB TECHNOLOGIES, IN...

1. A pipette controller comprising:a pipette holder adapted to operatively connect a pipette to the pipette controller;
a pressure tank pneumatically connected to the pipette holder;
a pump pneumatically connected to the pressure tank and configured to inject air into the pressure tank to create positive air pressure inside the pressure tank;
an aliquot valve controlling airflow between the pressure tank and the pipette holder;
an electronic control; and
a pressure tank pressure sensor that measures air pressure inside the pressure tank;
wherein the electronic control opens and closes the aliquot valve; and
wherein the electronic control opens the aliquot valve to begin dispensing an aliquot of fluid, and closes the aliquot valve when the air pressure measured by the pressure tank pressure sensor changes to a predetermined air pressure corresponding to an amount of air transferred from the pressure tank to the pipette holder to dispense a volume of fluid equal to an aliquot volume.

US Pat. No. 10,189,001

MULTIPLEXED SURFACE ENHANCED RAMAN SENSORS FOR EARLY DISEASE DETECTION AND IN-SITU BACTERIAL MONITORING

CALIFORNIA INSTITUTE OF T...

1. A method to produce a sensor for multiplexed detection of multiple biomolecules, comprising:providing a substrate, the substrate comprising at least one recessed region and nanopillars defined in the at least one recessed region;
attaching to said substrate a first plurality of first chemical linkers;
providing a second plurality of second chemical linkers, each second chemical linker capable of binding to a first chemical linker;
allowing the first and second pluralities of chemical linkers to interact under such conditions and for such a time as to allow binding of some or all of the chemical linkers of the second plurality to some or all of the chemical linkers of the first plurality to generate a third plurality of first and second chemical linkers, each first chemical linker of the third plurality bound to a second chemical linker of the third plurality, and a fourth plurality of first chemical linkers, each first chemical linker of the fourth plurality unbound to a second chemical linker of the fourth plurality; and
performing at least one functionalization step to produce a sensor for multiplexed detection of multiple biomolecules, each functionalization step comprising the steps of:
illuminating at least one area of the substrate to release the second chemical linkers of the third plurality of chemical linkers from being bound to the first chemical linkers of the third plurality of chemical linkers to expose the first chemical linkers of the third plurality attached to the substrate in that area; and
providing a plurality of molecular probes capable of attaching to the exposed first chemical linkers of the third plurality.

US Pat. No. 10,188,994

METHOD, APPARATUS AND SYSTEM FOR AFTERTREATMENT OF EXHAUST GAS

PROVENTIA OY, Oulunsalo ...

1. An apparatus for aftertreatment of exhaust gas comprising:a housing configured to define an inner cavity;
an exhaust inlet arranged to the housing for entering exhaust gas to the inner cavity;
a first flow guide in the inner cavity configured to guide at least part of the exhaust gas to a first direction to form a first direction flow, the first flow guide comprising:
an elongated blade extending across the inner cavity; and
a perforated tubular element, wherein at least part of the exhaust gas is configured to enter an interior of the perforated tubular element through apertures, the perforated tubular element being configured to guide the exhaust gas to a circulating and advancing movement in a first direction,
the first flow guide in the inner cavity is configured to form, using the exhaust gas, a center flow and an edge flow circulating and advancing around the center flow in the first direction;
a reactant inlet arranged to the housing for dispensing reactant to the first direction flow in the inner cavity, the reactant configured to mix with the exhaust gas, wherein mixing of the reactant and the exhaust gas occurs within center flow in the first direction flow, the second direction flow and the third direction flow, and the center flow is advancing inside the perforated tubular element in the first direction and the edge flow is circulating and advancing around the perforated tubular element in the first direction;
a second flow guide in the inner cavity located downstream from the first flow guide, the second flow guide configured to:
guide at least a part of the first direction flow to a second direction to form a second direction flow, wherein the second direction being opposite to the first direction; and
guide the second direction flow to a third direction to form a third direction flow, wherein the third direction being downstream to the second direction and parallel to the first direction; and
an exhaust outlet arranged to the housing for exiting output exhaust gas from the inner cavity, the exhaust outlet being downstream to the second flow guide,
wherein mixing of the reactant and the exhaust gas occurs within the first direction flow, the second direction flow and the third direction flow;
a solid tubular element downstream to the perforated tubular element and upstream to the second flow guide, configured to guide at least part of the first direction flow towards the second flow guide, wherein a diameter of the solid tubular element being greater than a diameter of a second end of the perforated tubular element and allowing a part of the circulating and advancing edge flow around the perforated tubular element to enter the solid tubular element.

US Pat. No. 10,188,990

DEVICE AND METHOD FOR POSITIONING A DETONATOR WITHIN A PERFORATING GUN ASSEMBLY

DynaEnergetics US, Inc., ...

1. A detonator positioning device for positioning a wireless detonator in a perforating gun assembly, the device comprising:a cylindrical body comprising an open end, a closed end, and a central bore adapted for receiving the detonator, the central bore extending along at least some of a length of the cylindrical body, the central bore including an enlarged bore portion adjacent the open end of the cylindrical body;
a plurality of arms extending toward the open end of the cylindrical body and at least partially enclosing the enlarged bore portion of the central bore, each of the plurality of arms adapted to retain a detonator head of the detonator when the detonator is positioned within the enlarged bore portion of the central bore; and
a plurality of legs extending from the cylindrical body and toward the closed end of the cylindrical body, each of the plurality of legs adapted to position the cylindrical body in the perforating gun assembly.

US Pat. No. 10,188,989

ELECTROOSMOTIC DEVICES FOR FLUID HANDLING

Ohio State Innovation Fou...

1. A device comprising:(a) a nanoporous membrane having a top surface and a bottom surface;
(b) a fluid source positioned in fluid contact with the bottom surface of the nanoporous membrane; and
(c) a porous electrode patterned on one of the top or bottom surfaces of the nanoporous membrane so as to define a fluid delivery region in fluid contact with the top surface of the nanoporous membrane;
wherein the porous electrode is configured such that, upon application of a potential bias across the nanoporous membrane, fluid flow is induced between the fluid source and the fluid delivery region.

US Pat. No. 10,188,983

SYSTEMS AND METHODS FOR CATALYST SCREENS IN SELECTIVE CATALYTIC REDUCTION REACTORS

Integrated Global Service...

1. A system for use in a selective catalytic reduction reactor, the system comprising:a catalyst bed; and
a screen located at a distance in a range of 1 in. to 12 ft. above the catalyst bed so that flow of flue gas to the catalyst bed contacts the screen or passes through the screen before the flow of flue gas contacts the catalyst bed or passes through the catalyst bed, the screen adapted to support a weight of at least 400 pounds above the catalyst bed so that the weight is not imposed on the catalyst bed, the screen having a plurality of holes across its surface, wherein the screen is adapted to change velocity distribution of the flue gas as it flows through the screen, wherein the change in velocity distribution as a result of the screen comprises a 3 to 6% decrease in Root Mean Square (RMS) of overall velocity distribution of the flue gas.

US Pat. No. 10,188,968

CANDLE FILTER SUPPORT AND PLATE ASSEMBLY FOR POLYMER MELTS

Westlake Longview Corpora...

1. A polymer melt filter support comprising:a hollow cylindrical body defined by a first end, a second end, and a cylinder wall having a first end portion and a second end portion;
a screw thread on the outside surface of the first end portion;
a plurality of holes in the cylinder wall at the second end portion;
an opening at the second end; and
a cone insert adapted to fit inside of the second end opening,
wherein the cone insert comprises a base plate,
wherein the perimeter of the top surface of the base plate comprises one or more recesses,
wherein the recesses and an inner surface of the cylindrical body define a reservoir for holding solder or weld metal for joining the cone insert to the cylindrical body,
wherein the holes allow for a polymer melt outside of the cylindrical body to flow inside of the cylindrical body,
wherein the first end comprises an opening for the polymer melt inside of the cylindrical body to flow outside of the cylindrical body,
wherein the area of the openings of the holes on the outside surface of the cylinder wall is larger than the area of the openings of the corresponding holes on the inside surface of the cylinder wall, and
wherein the shape of the openings of the holes on the outside surface is non-circular.

US Pat. No. 10,188,956

ASSEMBLY-TYPE EVOLUTIONARY GAME SYSTEM

ORGANIC CONSTRUCTION SYST...

1. An assembly-type evolutionary game system comprising the following components:a) extendable components of a base body which comprise:
a body abdomen-side part (8);
a first body back-side part (9);
a second body back-side part (10);
a third body back-side part (11);
a fourth body back-side part (12);
a fifth body back-side part (13); and
a sixth body back-side part (14);
wherein the extendable components include an internal extension metal array to extend and adjust proportions of the extendable components,
b) malleable structural joint pieces of the base body which comprise:
a short straight connection structural joint piece (1) with an end comprising a straight connection piece;
a middle straight connection structural joint piece (5) with an end comprising a straight connection piece;
a long straight connection structural joint piece (7) with an end comprising a straight connection piece;
a middle spherical connection structural joint piece (3) with an end comprising a spherical connection piece;
a long spherical connection structural joint piece (6) with an end comprising a spherical connection piece;
a mixed connection structural joint piece (2) with an end comprising a straight connection piece; and
a hand structural joint piece (4) including a hand connection piece;
wherein the malleable structural joint pieces are configurable to hold a shape after adjustment, and
c) rigid components of the base body which comprise:
a plurality of separate body parts, wherein each separate body part encloses a hollow portion and at least one clamp located at a curved portion of the body part and extending inwardly into the enclosed hollow portion within each separate body part, the plurality of separate body parts comprising:
a narrow rib (15);
a narrow limb connection main body (16);
a flat rib (18);
a flat limb connection main body (19),
wherein each of the plurality of separate body parts is configured to connect to at least one of the malleable structural joint pieces extending through the hollow portion using the at least one clamp thereon;
a plurality of additional rigid components comprising:
a thigh (17);
a knee (20);
an ankle (21);
a foot (22);
a wing (23);
a shin (24);
a fish tail piece (25) or a single tail piece (26);
a reptile head (27) or a fish head (29) comprising a skull and a jaw;
a crest (28);
a head connection component (30);
a front arm (31);
an elbow and wrist component (32); and
an arm (33),
wherein the extendable components connect to the malleable structural joint pieces, and
wherein coupling the components enables a formation of assembled components to create a diverse number of animals.

US Pat. No. 10,188,954

ARCADE GAME WITH INTEGRATED BEVERAGE SENSOR

Glitchbit LLC, Tallmadge...

1. An arcade game comprising:one or more processors for executing an arcade game having one or more participants;
a visual display screen; and
a countertop control panel, the countertop control panel comprising:
at least one game input by which a participant can control the arcade game;
at least one beverage receptacle to hold a beverage container in an upright orientation; and
at least one beverage sensor to distinguish one or more beverage states and to communicate the distinguished one or more beverage states to the arcade game as gameplay activation inputs to the arcade game.

US Pat. No. 10,188,949

GAME OBJECT CONTROL SYSTEM AND PROGRAM

EARTHBEAT, INC., Shibuy-...

1. A game object control system which invokes various event processes to progress a game in a virtual world where a character corresponding to a user and other objects move, comprising:a game progress processing unit which progresses the game by invoking the various event processes;
a real map storage unit which stores real map information containing geographical information in a real world;
a virtual map information generation unit which generates virtual map information including coordinate information of the objects on virtual geographical information corresponding to the geographical information on the real map information in accordance with a game progress by the game progress processing unit;
a positional information acquisition unit which selects a coordinate position in the real world;
a real display data generation unit which generates real display data indicating the coordinate position selected by the positional information acquisition unit on the real map information on the basis of the coordinate position;
a virtual display data generation unit which generates virtual display data showing the character on the virtual map information corresponding to the coordinate position acquired by the positional information acquisition unit on the basis of the coordinate position;
a moving path recording unit which calculates and records a moving path on the basis of a displacement history of the coordinate position selected by the positional information acquisition unit;
a trail display unit which displays, as trails, the moving path recorded by the moving path recording unit on the real map information or the virtual map information; and
a display control unit which displays both or selected one of the virtual display data generated by the virtual display data generation unit and the real display data generated by the real display data generation unit, or displays part of either one overlapping the other, together with the trail displayed by the trail display unit,
wherein the positional information acquisition unit acquires the current position of another user in the real world, and selects, as the coordinate position, the position in which an object to be a proxy of the user is arbitrarily set on the real map information or the virtual map information as a proxy object, and
wherein the game progress processing unit sets the position of the proxy object in the map information on the basis of the position of the another user, and automatically moves the proxy object in accordance with the progress of the game.

US Pat. No. 10,188,948

GAME IMAGE PROCESSING SYSTEM AND PROGRAM

EARTHBEAT, INC., Shibuya...

1. A game image processing system which invokes various event processes to progress a game in a virtual world where a character corresponding to a user and other objects move, comprising:a game progress processing unit which progresses the game by invoking the various event processes;
a real map storage unit which stores real map information containing geographical information in a real world;
a virtual map information generation unit which generates virtual map information including coordinate information of the objects on virtual geographical information corresponding to the geographical information on the real map information in accordance with a game progress by the game progress processing unit;
a positional information acquisition unit which selects a coordinate position in the real world;
a real display data generation unit which generates real display data indicating the coordinate position selected by the positional information acquisition unit on the real map information on the basis of the coordinate position;
a virtual display data generation unit which generates virtual display data showing the character on the virtual map information corresponding to the coordinate position acquired by the positional information acquisition unit on the basis of the coordinate position; and
a display control unit which displays both or selected one of the virtual display data generated by the virtual display data generation unit and the real display data generated by the real display data generation unit, or displays part of either one overlapping the other,
wherein the virtual display data generation unit coaxially arranges a plurality of low resolution maps having stepwise reduced scales and increased areas around a detailed map having a greater scale in a predetermined coordinate position as a center, and performs a fade process at a boundary area between the detailed map and the low resolution map and a boundary area between one and another of the low resolution maps to gradually transition one image to the other image.

US Pat. No. 10,188,935

SYSTEM FOR A TOURING SKI-BINDING COMPRISING A FRONT UNIT AND A HEEL UNIT

Markus Steinko, Ascholdi...

1. A system for a touring ski-binding comprising a front unit and a heel unit comprising a heel member, wherein the heel member comprises a reception bowl for receiving a heel part of a ski boot,a biasing device for biasing the heel unit against a ski boot, wherein the heel member is pivotally disposed around a pivot axis, wherein the pivot axis runs horizontally, transverse to a longitudinal direction of a ski, and
a stopper plate for releasing a ski stopper, wherein the stopper plate is switchable between an adjacent position and a protruding position, wherein the stopper plate is configured to leave the adjacent position when the touring ski binding is released, wherein the heel unit is switchable between a starting position for providing a walking function and for receiving a ski boot, and a snap-in position for retaining the ski boot,
wherein the heel unit comprises a blocking element configured to block the stopper plate in the adjacent position, wherein the blocking element is configured to switch, with respect to the pivot axis, between a blocking position and a non-blocking position depending on the position of the heel member, wherein with respect to a downhill mode the front unit in a climbing mode of the touring ski-binding is displaced to the front in the longitudinal direction of the ski, so that a ski boot present in the touring ski-binding cannot contact the heel member of the heel unit.

US Pat. No. 10,188,905

SYSTEM FOR PROCESSING EXERTION DATA DERIVED FROM EXERTION DETECTION DEVICES

Tri2Focus, Inc., Cypress...

1. A method for implementing an electronic feedback loop based on exertion data derived from one or more exertion sensors including at least one of a bicycle power meter, a heart rate monitor, or a global positioning satellite watch, the method comprising:generating, by an exertion sensor data processor, a workout schedule, wherein the generating includes
querying an electronic database for a race date, race performance goal, and athlete capability parameters;
determining a number of time units between a current date and the race date;
for each time unit of the number of time units
determining, by the workout processor, a prescribed stress level for the time unit;
generating by the workout processor, workouts that subject an athlete to the prescribed stress level for the time unit; and
storing the workouts in the workout schedule in the electronic database detecting, via the one or more exertion sensors, physical exertion during at least one of the workouts;
computing, by the exertion sensor data processor, an actual stress level for the at least one of the workouts, wherein the computing is based on the exertion data derived from the one or more exertion sensors;
querying, by the exertion sensor data processor, the electronic database for the prescribed stress level for the at least one of the workouts;
determining, by the exertion sensor data processor, that the actual stress level is less than the prescribed stress level for the at least one of the workouts;
in response to determining that the actual stress level is less than the prescribed stress level for the at least one of the workouts, modifying, by the exertion sensor data processor, the workout schedule; and
transmitting, over the electronic communications network, an electronic workout data file including the modified workout schedule for presentation on a remote display device.

US Pat. No. 10,188,868

DEVICE SUPPORT APPARATUS

Nexstim Oyj, Helsinki (F...

21. A system for Transcranial Magnetic Stimulation (TMS) comprising:a TMS coil device having at least one cable extending therefrom,
a chair with a back portion and a seat portion,
a first arm having a device attachment portion at one end configured to lockably receive the TMS coil device, said first arm further having a cable attachment portion configured to receive the at least one cable extending from the TMS coil device;
a second arm supporting the first arm by a coupling;
a base attached to a portion of the chair, said base comprising a curved portion and having the second arm mounted directly on the curved portion at an attachment point, wherein the curved portion is at least in part formed in the shape of a curve, the attachment point being configured to move along a length of the curve of the curved portion while remaining directly mounted on the curved portion, the shape of the curved portion enabling movement of the transcranial magnetic stimulation device to different sides of a head.

US Pat. No. 10,188,852

PATCH ABLE TO PRODUCE MICROCURRENTS

FASTMEDITALIA S.R.L., De...

1. A patch able to produce microcurrents, comprising:a support for electrodes spaced from each other and able to create voltages typical of galvanic piles, the support comprising a moisture-permeable membrane;
connection means between said electrodes;
an adhesive layer applied on one side of said support and able to adhere to the skin; and
a protection liner applied on the adhesive layer,
wherein the connection means are defined by a material avid of moisture impregnating the membrane that captures sweat fluid molecules when in contact with skin, allowing for ion exchange between the electrodes.

US Pat. No. 10,188,745

BINDING PROTEIN DRUG CONJUGATES COMPRISING ANTHRACYCLINE DERIVATIVES

NBE-THERAPEUTICS AG, Bas...

1. A binding protein-drug conjugate (BPDC) comprising an anthracycline (PNU) derivative, the BPDC having the following formula:
wherein
a) each of L1-L3 represents a linker, wherein L1 is optional and both L2 and L3 are mandatory,
b) L1, when present, represents an alkylene-amino linker or an alkylene-diamino linker,
c) L2 represents an oligo-glycine peptide,
d) L3 represents a peptide motif that results from specific cleavage of a sortase enzyme recognition motif,
e) X and Y each represent one or more optional linkers,
f) BP is a binding protein, and
g) n is an integer ?1 and ?10.

US Pat. No. 10,188,656

METHODS OF TREATMENT OF MALIGNANCIES

Agios Pharmaceuticals, In...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-[2-(trifluoromethyl)pyridin-4-yl]amino-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:
or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of NRAS.

US Pat. No. 10,188,651

METHODS OF TREATING SLEEP DISORDERS

Melior Pharmaceuticals II...

1. A method of treating a sleep disorder associated with altered sleep rhythm and/or architecture in a mammal comprising administering to the mammal in need thereof an effective amount of a compound of Formula Ia-1, Formula Ia-2, Formula Ib-1, Formula Ib-2, Formula Ic-1, Formula Ic-2, Formula Id-1, or Formula Id-2:or a pharmaceutically acceptable salt thereof, wherein the sleep disorder associated with altered sleep rhythm and/or architecture is insomnia, restless legs syndrome, narcolepsy, REM sleep behavior disorder, or disrupted circadian rhythm associated with sleep apnia, shift work, or jet lag; wherein:U is C;
each R1 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl, where r is 0, 1, 2, 3, 4, or 5;
each R2 and R3 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where n is 0, 1, 2, 3, or 4;
each R4 and R5 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where p is 0, 1, 2, 3, or 4;
W is H or C1-C6alkyl;
Y is H, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylamino sulfinylalkyl;
X is O or S;
Z is O or S;
R7 is H or halo;
Q is H, C1-C6alkyl, aryl, C1-C6alkylaryl, C3-C6cycloalkyl, or heteroaryl, each of which is optionally substituted with —(R6)t, where t is 0, 1, 2, 3, 4, or 5;
R8 is H or C1-C6alkyl; and
each R6 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —O—S(?O)2OH, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, —C(?O) C1-C6alkyl, —C(?O) C1-C6alkoxy, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl; or pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,636

BETAHISTINE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Cipla Limited, Mumbai (I...

1. A method of treating a neurodegenerative disease, comprising administering to a subject in need thereof, a therapeutically effective amount of betahistine or a pharmaceutically acceptable salt thereof, wherein the neurodegenerative disease is Alzheimer's disease and wherein the betahistine or a pharmaceutically acceptable salt thereof is administered orally in an amount from 250-5,000 mg/week with a pharmaceutically acceptable carrier or excipients.

US Pat. No. 10,188,626

STABILIZED CABAZITAXEL FORMULATIONS

Cipla Limited, Mumbai (I...

1. A pharmaceutical composition, comprising a compound having the formula:or a pharmaceutically acceptable salt thereof and at least one solubilizer comprising a caprylocaproyl polyoxylglyceride, wherein the composition is injectable, further comprising albumin.

US Pat. No. 10,188,623

ENHANCED BIOAVAILABILITY OF POLYUNSATURATED FATTY ACIDS

Patheon Signals Inc., Hi...

1. An oral pharmaceutical composition comprising an enteric soft capsule shell comprising gelatin and an enteric polymerwherein a weight ratio of the enteric polymer and gelatin is 1:2.6; and
wherein the shell encapsulates a matrix fill comprising at least 94% by weight eicosapentaenoic free fatty acid (EPA) and less than 1% by weight docosahexaenoic acid (DHA).

US Pat. No. 10,188,610

PROLONGED-RELEASE DIPHENIDOL COMPOSITION

INVEKRA, S.A.P.I. DE C.V....

1. A sustained release diphenidol single layer tablet, consisting of: a) from 15 to 50% diphenidol hydrochloride; b) from 0.1 to 20% of one or more binding agents; c) from 5 to 90% of one or more diluent agents; d) from 5 to 50% of one or more release modification agents; e) from 0.25 to 10% of one or more lubricating agents; and f) 0.1 to 10% of one or more gliding agents, wherein all of the ingredients of the tablet are mixed together prior to tabletting.

US Pat. No. 10,188,599

ANTI-INFLAMMATORY ACTIVITY WITH SYNERGISM OF HERBAL ESSENTIAL OILS

BORDOLOI BIOTECH, LLC, B...

1. A topical synergistic anti-inflammatory formulation comprising a blend of essential oils, wherein the blend includes at least three essential oils selected from:(A) Cymbopogon citratus oil (CC oil),
(B) Zanthoxylum armatum oil (ZA oil),
(C) Hedychium spicatum oil (HS oil), and
(D) a fourth essential oil obtained from basil, caraway, carrot seed, celery seed, chamomile, citronella, clary sage, clove, cumin, lemon, marjoram, nutmeg, orange, sage, sandalwood, spearmint, and/or thyme.

US Pat. No. 10,188,575

CERVICAL ORTHOTIC DEVICE

Core Products Internation...

1. A cervical orthotic device comprising:a base having a length and a width;
sidewalls extending upwardly from the base, wherein the sidewalls include:
opposingly paired lateral sidewalls; and
opposingly paired longitudinal sidewalls:
a cervical support surface opposite said base and uniting said sidewalls, the cervical support surface having a cervical engagement ridge extending parallel with, and in the same direction as, the width of the base, the cervical support surface also including:
a first planar portion adjacent a first longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom;
a second planar portion adjacent a second longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom; and
an arcuate portion intermediate the first planar portion and the second planar portion and extending from a first lateral sidewall of the opposingly paired lateral sidewalls to the other lateral sidewall of the opposingly paired lateral sidewalls, the arcuate portion delimiting the cervical engagement ridge for the cervical support surface;
wherein an apex of the cervical engagement ridge defines a height of the cervical orthotic device from the base;
wherein a ratio of a maximum height of the cervical orthotic device to the length is greater than or equal to 1.1575; and
wherein a height of the first longitudinal sidewall of the opposingly paired longitudinal sidewalls is about 1.5 times a height of the second longitudinal sidewall of the opposingly paired longitudinal sidewalls.

US Pat. No. 10,188,573

BOOT STIRRUP

Allen Medical Systems, In...

1. A boot stirrup for use during surgery, the boot stirrup comprisinga support arm having a longitudinal axis,
a surgical boot including a foot support portion formed to support a foot of a patient and a boot handle fixed to the foot support portion, the boot handle extending from a heel support region of the surgical boot, and
a lockable joint coupled to the support arm and coupled to the surgical boot, the lockable joint being configured to move between an unlocked position in which the lockable joint permits movement of the surgical boot along the longitudinal axis relative to the support arm and rotation of the surgical boot about the longitudinal axis relative to the support arm and a locked position in which the lockable joint blocks movement of the surgical boot along the longitudinal axis relative to the support arm and rotation of the surgical boot about the longitudinal axis relative to the support arm, and the lockable joint includes a release lever configured to move relative to the boot handle to unlock the lockable joint, wherein the release lever includes a grip portion that is spaced from the boot handle when the lockable joint is in the locked position and that is adjacent to and in aligned, side-by-side, substantially parallel registry with the boot handle when the lockable joint is in the unlocked position.

US Pat. No. 10,188,547

APPARATUS AND METHOD FOR USING A PORTABLE THERMAL DEVICE TO REDUCE ACCOMMODATION OF NERVE RECEPTORS

CAREWAVE MEDICAL, INC., ...

1. A heating device for therapeutically heating skin to reduce accommodation of thermal nerve receptors, comprising:a heat delivery element adapted to be worn proximate to the skin of a user; and
a microprocessor control unit configured to control the heat delivery element;
wherein the microprocessor control unit is programmed to maintain at least one cycle of skin temperature having:
a ramp-up temperature period,
a peak temperature,
a ramp-down temperature period, and
a soak temperature,
wherein the soak temperature is lower than the peak temperature, and wherein the soak temperature is greater than a body temperature.

US Pat. No. 10,188,543

FOLDING MENSTRUAL CUP

Guangzhou Tianyuan Silico...

1. A folding menstrual cup comprising:an outer cup body with a top and a bottom, wherein a top accommodating cavity is formed inside the outer cup body and a round opening is provided at the top of the outer cup body; at a side opposite to the opening, the bottom of the outer cup body is connected to a flow guiding pipe via a folding part;
the flow guiding pipe with a pipe orifice in communication with the top accommodating cavity of the outer cup body, where a valve controlling communication to the pipe orifice is arranged on the flow guiding pipe; and
the folding part being capable of protruding upward and enabling the top end of the flow guiding pipe to extend into the top accommodating cavity of the outer cup body along with the folding part; wherein the folding part is capable of straightening downward and a bottom accommodating cavity is formed inside the folding part.

US Pat. No. 10,188,536

STENT-VALVE, DELIVERY APPARATUS, AND STENT-HOLDER THEREFOR

SYMETIS SA, Ecublens (CH...

1. A delivery device for delivering a stent-valve to an anatomical site for implantation, the delivery device comprising:a stent-holder; and
at least one projection extending radially away from an exterior surface of the stent-holder at a first distance, each projection being disposed within an individual recess formed in a body of the stent-holder wherein the body at least partially surrounds each projection;
wherein:
the at least one projection includes a trunk portion having a first thickness and a ramp portion having a second thickness,
wherein the trunk portion extends radially outward from the exterior surface,
the ramp portion comprises a web of material extending along and from the exterior surface up to or adjacent the first distance, and the ramp portion faces, or is provided on a side of the projection that faces, at least one of a proximal direction of the device and away from a distal end of the device, and
the ramp portion extends laterally from the trunk portion, and the second thickness is less than the first thickness.

US Pat. No. 10,188,515

DEVICES AND METHODS FOR CRIMPING A MEDICAL DEVICE

MEDTRONIC VASCULAR INC., ...

1. A system for crimping a prosthetic valve comprising:a first funnel, the first funnel comprising a first diameter of the first funnel, a tapered section, and a second diameter of the first funnel smaller than the first diameter of the first funnel;
a second funnel, the second funnel comprising a first diameter of the second funnel, a tapered section, and a second diameter of the second funnel smaller than the first diameter of the second funnel;
a delivery device, the delivery device comprising a strut support and an outer sheath, at least a portion of the delivery device extending through the first funnel and the second funnel wherein
the second diameter of the first funnel and the second diameter of the second funnel face towards each other,
the second diameter of the first funnel engages with the second diameter of the second funnel, and
the first diameter of the first funnel and the first diameter of the second funnel face away from each other; and
an actuator comprising a handle, a channel, a pull ring, and at least one wire operatively attached to the pull ring, an end of the at least one wire configured to attach to the prosthetic valve and pull the prosthetic valve through at least one of the first funnel and the second funnel through sliding of the pull ring;
wherein the first diameter of the first funnel is larger than the first diameter of the second funnel.

US Pat. No. 10,188,424

TROCAR SET

MEGAFORCE COMPANY LIMITED...

1. A trocar set, comprising:a handle portion comprising a grip, a connection part, and a first gas valve, wherein the connection part extends from the grip and comprises an assembling channel, and the first gas valve is connected to the connection part and communicates with the assembling channel;
a first sleeve comprising an assembling end, a sleeving end, a first gas flow channel, a first inner sleeve wall and a first outer sleeve wall, wherein the assembling end is assembled to the assembling channel and is disposed corresponding to the first gas valve, a sleeve wall of the sleeving end is provided with at least one first opening, the first sleeve defines a first sleeve wall region and a second sleeve wall region, the first outer sleeve wall surrounds an exterior of the first inner sleeve wall in the first sleeve wall region, the first outer sleeve wall does not surround the exterior of the first inner sleeve wall in the second sleeve wall region, and the first opening is disposed on the first outer sleeve wall;
a second sleeve comprising a second gas flow channel, wherein the second sleeve is retractably connected to the sleeving end of the first sleeve, and a sleeve wall of the second sleeve is provided with at least one second opening; and
a gasbag connected to an end of the second sleeve away from the first sleeve and corresponding to the second opening;
wherein the gasbag is capable of being inflated through the first gas flow channel, the first opening, the second gas flow channel, and the second opening.

US Pat. No. 10,188,415

FORCEPS AND FORCEPS UNIT

MASANORI ISHII, Kofu-Shi...

1. A forceps for gripping tissue, the forceps comprising:a rod-like tubular shaft having a penetrating hole formed in an axial direction;
a rod-like inserted member inserted inside the tubular shaft and being movable in the axial direction inside the tubular shaft;
a gripping portion provided at a distal end of the inserted member and coupled to a distal end of the tubular shaft, the gripping portion including a pair of gripping members capable of opening and closing, each of the gripping members having a distal end portion that applies a force for gripping on the tissue and a pulling portion to which the force for gripping is applied via movement of the inserted member;
a handle coupled to a terminal end of the inserted member; and
a fixing portion detachably fixing the handle to the tubular shaft in a state where the handle is coupled to the inserted member; and
wherein a main body of the tubular shaft includes a mid-section of the tubular shaft between a terminal end of the tubular shaft and the distal end of the tubular shaft,
wherein the distal end of the tubular shaft has a larger diameter than a diameter of the terminal end of the tubular shaft and a diameter of an entirety of the main body of the tubular shaft,
wherein the distal end of the tubular shaft is coupled to a connecting portion at a terminal end of the gripping portion,
wherein a joint portion, having a smaller diameter than the diameter of the entirety of the main body of the tubular shaft, is formed at the terminal end of the inserted member, and the handle is provided with a joint receptacle that houses the joint portion and is advanced and retracted by manipulation of the handle,
wherein the fixing portion includes:
a chuck member having an insertion hole formed therein and configured for locking the terminal end of the tubular shaft in the axial direction, and
a fixing ring having an insertion hole formed therein and coupled to a coupling portion provided on the handle, and
wherein the chuck member is fixed by the fixing ring to the handle in a state in which the terminal end of the tubular shaft, with the inserted member inserted therein, is inserted in the chuck member and the fixing ring, the joint receptacle of the handle and the joint portion of the inserted member are coupled, and the chuck member is sandwiched between the fixing ring and the handle,
wherein the chuck member and the fixing ring are separable from the handle, and the distal end of the tubular shaft into which the inserted member is inserted is inserted into the chuck member and the fixing ring separated from the handle, and
wherein the fixing ring is not fixed to the tubular shaft when the fixing ring is separated from the handle.

US Pat. No. 10,188,381

SUTURE REPAIR DEVICE

Dura Tap LLC, Wayne, PA ...

1. An apparatus, comprising:a handle having a proximal end portion and a distal end portion;
a cartridge having a proximal end portion and a distal end portion, the proximal end portion configured to be removably coupled to the distal end portion of the handle, the distal end portion of the cartridge having a first needle assembly and a second needle assembly each configured to be transitioned between a first configuration and a second configuration, the first needle assembly including a first needle and a first capture member, the second needle assembly including a second needle and a second capture member;
an actuator movably coupled to the handle, the actuator having a first coupling portion operably coupled to the first needle assembly when the cartridge is coupled to the handle and a second coupling portion operably coupled to the second needle assembly when the cartridge is coupled to the handle, the first coupling portion configured to move relative to the handle in response to a first force to transition the first needle assembly from the first configuration in which the first capture member is spaced apart from the first needle to the second configuration in which the first capture member engages the first needle, the second coupling portion configured to move relative to the handle in response to a second force to transition the second needle assembly from the first configuration in which the second capture member is spaced apart from the second needle to the second configuration in which the second capture member engages the second needle; and
a lock operably coupled to the actuator, the lock configured to selectively limit movement of the first coupling portion and the second coupling portion,
wherein the actuator includes a selector coupled to the lock, the selector configured to transition between a first configuration in which the lock limits movement of the second coupling portion and a second configuration in which the lock limits movement of the first coupling portion.

US Pat. No. 10,188,380

SUTURE ANCHOR SYSTEM WITH COMPRESSIBLE DISTAL TIP

DePuy Mitek, LLC, Raynha...

1. A method for anchoring tissue to bone, comprising:advancing a bone anchor partially into a bone hole such that the anchor engages the bone and is secured within the bone hole, the bone anchor having a suture extending through an inner lumen of the bone anchor and coupled to a distal portion of the bone anchor;
tensioning the suture, with the bone anchor partially advanced into the bone hole, to tension tissue coupled to the suture; and
after tensioning, further advancing the bone anchor into the bone hole to cause the distal portion of the bone anchor to compress radially inward and lock the suture therein.

US Pat. No. 10,188,352

ACNE-AFFECTED SKIN DETERMINATION METHOD AND ACNE-AFFECTED SKIN DETERMINATION DEVICE

FUJIFILM Corporation, Mi...

1. An acne-affected skin determination method comprising:setting an upper region and a lower region so as to vertically divide the face of a subject into two regions,
acquiring amount of moisture of a plurality of measurement sites in the lower region;
acquiring amount of moisture of a plurality of measurement sites in the upper region;
calculating an average value of the amounts of moisture of the plurality of measurement sites in one of the upper region or the lower region as a target moisture value, setting a region including the other of the upper region and the lower region as a reference region and calculating an average value of the amounts of moisture of the plurality of measurement sites;
obtaining a difference in moisture of the target moisture value with respect to the reference moisture value; and
determining the ease of generation of acne in the face of the subject based on the difference in moisture obtained.

US Pat. No. 10,188,343

METHODS OF MONITORING EFFECTS OF NEUROSTIMULATION

Cardionomic, Inc., New B...

1. A method of monitoring effect of neurostimulation on left ventricle contractility, the method comprising:positioning a neurostimulator in a pulmonary artery;
positioning a plurality of pressure sensors in a right ventricle;
activating the neurostimulator to apply neurostimulation to a nerve proximate to a pulmonary artery, wherein the neurostimulation increases contractility of the left ventricle;
measuring contractility of the right ventricle using the plurality of pressure sensors;
determining contractility of the left ventricle based on the measured contractility of the right ventricle;
monitoring the effect of the neurostimulation on the left ventricle contractility based on the measured contractility of the right ventricle; and
using closed loop control to alter the neurostimulation.

US Pat. No. 10,188,337

AUTOMATED CORRELATION OF NEUROPSYCHIATRIC TEST DATA

SAVONIX, INC., San Franc...

1. A data processing method comprising:loading a mobile computing device with test instructions upon startup of an application installed on the mobile computing device;
under program control of the test instructions programmed in the mobile computing device, generating and causing displaying on a display device of the mobile computing device, a prompt associated with a first task relating to a test of a feature of a human cognitive domain, wherein the prompt comprises a prompt image of spatially positioned shapes and lines;
in conjunction with causing displaying the prompt, by the test instructions, reading a system clock of the mobile computing device and storing a first time stamp value indicating when the prompt was displayed;
wherein the system clock continuously generates signals representing a current time that may be queried programmatically by the application;
using the test instructions, displaying the prompt for a specified time period using the system clock;
in response to displaying the prompt for the specified time period, causing displaying a graphical grid that is configured to capture movement input at the mobile computing device wherein the movement input comprises drawing or placing shapes and lines to recreate the prompt image;
by the test instructions, obtaining input via the grid displayed through the mobile computing device comprising a response to the prompt, wherein the response comprises the movement input of shapes, icons, characters, or lines;
in conjunction with obtaining the input, by the test instructions, reading the system clock of the mobile computing device and storing a second time stamp value indicating when the input comprising the response was detected, and storing, in association with the second time stamp value, a tag indicating the movement input for the response;
by the test instructions, repeating the generating and causing displaying, the obtaining, the storing the tag, and the storing the first time stamp value and the second time stamp value, for a plurality of other prompts of other tasks relating to the same test or the same first task, to yield a plurality of test records that associate a plurality of different response values with a plurality of respective different time stamp values, and transmitting the plurality of different response values and the plurality of respective different time stamp values over a data communications network to a server computer that is programmed with test analysis instructions;
by the test analysis instructions, based upon the plurality of different response values and the plurality of respective different time stamp values, determining a first result score value for the first task, applying a first weight value to the first result score value to yield a first weighted result score value, and combining one or more other different weighted result score values associated with the other prompts of the other tasks relating to the same test, or the same first task, with the first weighted result score value to yield a cognitive domain score value;
with the server computer, causing generating and displaying one or more different graphs of the features of the cognitive domain, including a brain profile type;
further comprising, with the server computer, causing generating and displaying the one or more different graphs of the features of the cognitive domain, including the brain profile type, in which the different weighted result score values are indicated as positions within a normal distribution of score values for those features.

US Pat. No. 10,188,323

SYSTEMS, APPARATUS, AND METHODS FOR USING EYEWEAR, OR OTHER WEARABLE ITEM, TO CONFIRM THE IDENTITY OF AN INDIVIDUAL

Vision Service Plan, Ran...

1. A method of providing a particular individual with access to a computer system or computer program, the method comprising:a. receiving at least one wireless signal from a pair of computerized eyewear, the at least one wireless signal comprising a unique identifier associated with the particular individual;
b. at least partially in response to receiving the at least one wireless signal, comparing the unique identifier with a stored identifier for the particular individual; and
c. at least partially in response to determining that the unique identifier at least partially matches the stored identifier, providing the particular individual with access to the computer system or computer program.

US Pat. No. 10,188,320

LAPAROSCOPIC TISSUE THICKNESS MEASURING DEVICE AND METHOD OF USE

Boehringer Technologies, ...

1. A laparoscopic device for measuring the thickness of tissue, said device comprising:an elongated tubular housing having a central longitudinal axis and a proximal end portion;
a tissue thickness indicator comprising a tubular section, an indicator scale and a marker, said tubular section being located at said proximal end portion of said elongated tubular housing and coaxial with said central longitudinal axis, said indicator scale comprising indicia disposed linearly along said central longitudinal axis;
a reciprocating linear member coupled to said tissue thickness indicator, said reciprocating linear member having a first portion configured for reciprocating linear movement within said tubular housing along said central longitudinal axis and a second portion configured for reciprocating linear movement along said central longitudinal axis in said tubular section, wherein one of said indicator scale and said marker is fixedly located at said proximal end portion of said elongated tubular housing and the other of said indicator scale and said marker is fixedly located at said proximal end portion of said reciprocating linear member; and
a pair of jaws, each of said jaws having a tip portion, at least one of said jaws being movable with respect to the other of said jaws to define an openable and closable mouth between said tip portions of said jaws, said mouth being configured to be opened upon movement of said reciprocating linear member through said elongated tubular housing, whereupon said mouth is enabled to receive tissue therein, said reciprocating linear member being normally biased by a force to automatically close said mouth, said device being configured whereupon the closing of said mouth causes the movement of said reciprocating linear member along said central longitudinal axis a greater distance than the distance separating said tip portions of said jaws and said movement of said reciprocating linear member along said central longitudinal axis causes one of said marker and said indicator scale to move linearly along said central longitudinal axis with respect to the other of said marker and said indicator scale to provide a readily visible indication of the distance separating said tip portions of said jaws, and hence the thickness of tissue within said openable mouth.

US Pat. No. 10,188,310

PROBE FOR DETERMINING MAGNETIC MARKER LOCATIONS

Health Beacons, Inc., Co...

1. A method for determining a distance and direction between a probe and a magnetic marker, the method comprising:providing the probe, wherein the probe comprises
a first sensor including a first magnetometer having a first range within which a magnetic marker can be detected and a first accelerometer, and
a second sensor including a second magnetometer having a second range within which the magnetic marker can be detected and a second accelerometer,
wherein the first sensor is separated from the second sensor by a distance that is greater than the first range and the second range such that the magnetic marker can only be detected by one of the first magnetometer and the second magnetometer at a time;
wherein the probe is configured to determine a position, in three-dimensional space, of the magnetic marker;
balancing the probe while the probe is positioned away from the magnetic marker such that the magnetic marker is not within the first range of the first magnetometer or the second range of the second magnetometer;
moving the balanced probe so that the magnetic marker is within the first range of the first magnetometer and not within the second range of the second magnetometer; and
determining the distance and direction between the probe and the magnetic marker by comparing an output of the first sensor with an output of the second sensor.

US Pat. No. 10,188,304

INTEGRATED OPTICAL NEURAL PROBE

Diagnostic Biochips, Inc....

1. A neural probe comprising a headstage connected to one or more elongated shanks, whereinthe headstage comprises a high-intensity LED;
each elongated shank is formed from MEMS silicon and comprises at least one optical fiber, at least one groove, and at least one SUB waveguide, wherein each optical fiber is aligned in one groove to one waveguide; and
the LED is connected to each optical fiber via a coupler, wherein the coupler comprises ceramic, stainless steel, and brass, and wherein the coupler is fixed onto the LED with a UV-curable adhesive.

US Pat. No. 10,188,300

INFRARED THERMOMETER

BIO ECHO NET INC., Sappo...

1. An infrared thermometer capable of measuring a body temperature in no contact with a human body, comprising:a main unit;
an infrared sensor accommodated in the main unit;
a distance sensor configured to detect a distance between the main unit and the human body when the main unit approaches the human body; and
a controller configured to calculate the body temperature of the human body based on quantity of infrared from the infrared sensor when the distance sensor detects that the distance between the main unit and the human body is within a predetermined distance, wherein
the distance sensor comprises
a light source for emitting light;
a projector lens for projecting the emitted light from the light source toward the human body;
a light receiving sensor; and
a light receiving lens that allows the light receiving sensor to receive returned light, which is obtained as a result of the emitted light being reflected by the human body, when the distance between the main unit and the human body is within the predetermined distance, wherein
the projector lens and the light receiving lens have a same semi-circular arc-shape, and at least partially and concentrically surround the infrared sensor.

US Pat. No. 10,188,293

METHOD AND APPARATUS FOR FIXATION MEASUREMENT AND REFRACTION ERROR MEASUREMENT USING WAVE-FRONT ERROR

REBIScan, Inc., Cambridg...

1. An apparatus for fixation measurement for diagnosing strabismus, the apparatus comprising:an image projector configured to project a stimulus onto both eyes of a patient, wherein the stimulus is simultaneously projected onto the retinas of both eyes of the patient and simultaneously reflected onto a pair of image sensing devices
the pair of image sensing devices being disposed conjugate to the retinas, wherein the image sensing devices are configured to capture reflected images including light reflected from the retinas in response to the stimulus, wherein the reflected images include a reflected stimulus comprising one or more of: the stimulus as perceived on the retinas or the stimulus as transformed by a curvature of the retinas, and wherein differences between the stimulus and the reflected stimulus indicate fixation of the eyes; and
one or more computing devices configured to determine a misalignment in the fixation of the eyes corresponding to strabismus.

US Pat. No. 10,188,286

TOMOGRAPHIC IMAGE CAPTURING DEVICE

KOWA COMPANY, LTD., (JP)...

1. A tomographic image capturing device comprising:a tomographic image capturing means that scans measurement light on a subject's eye fundus to capture tomographic images of the subject's eye fundus; and
an image processing means that compresses a picture of the captured tomographic images in a scan direction to generate a new tomographic picture.

US Pat. No. 10,188,279

DISPOSABLE, SELF-CONTAINED LARYNGOSCOPE AND METHOD OF USING SAME

Adroit Surgical, LLC, Ok...

1. A laryngoscope comprising:a tube having an outer surface, an inner surface, a distal end and a proximate end defining a lumen there through, said tube having a longitudinal channel positioned about the circumference of said tube and extending from the outer surface thereof to the inner surface thereof for guiding light from its proximate end to its distal end;
a handle assembly and a power source mounted within said handle assembly, said handle assembly having a distal end and a proximate end wherein said proximate end is adapted to releasably attach to an optical subassembly; and
said optical subassembly comprising a light source for coupling to the power source and a housing supporting the light source, said light source positioned to supply light into the longitudinal channel.

US Pat. No. 10,188,256

SCRAPER ASSEMBLY

MIW ASSOCIATES, LLC, Hav...

1. A scraper for use in abrading a surface, comprising:a scraper head including:
a chainmail abrader having a chainmail body including a plurality of interlinked rings; and
elastic back pressure member positioned adjacent to a working surface of said chainmail body configured to apply pressure against the chainmail body to enable the working surface of the chainmail body and elastic back pressure member to resiliently conform to contours of the surface during scraping, wherein the working surface of the chainmail body and the elastic back pressure member are free to move independent of one another.

US Pat. No. 10,188,234

CHRISTMAS TREE MOISTURE SENSOR

Belac Products, LLC, Lew...

1. A moisture sensor comprising:a housing adapted to mount onto a tree stem,
a probe attached to the housing and adapted to detect water levels in a tree stand, the probe detects the conductivity of water to determine the water level,
a conductive rod with insulators at each opposing end wherein the probe is
separated by one insulator at a first end of the conductive rod and the other end of the conductive rod is inserted into the housing,
a PC board within the housing for determining water levels in the tree stand, a LED indicator adapted to provide a visual signal when water levels are below a threshold in the tree stand, and
a speaker adapted to provide an audio signal when water levels are below the threshold in the tree stand,
wherein the LED indicator signals the visual alert and the speaker signals the audio alert when the probe detects that the water level is below a threshold,
wherein the probe detects the conductivity of water to determine the water level,
wherein the probe comprises a copper wire connected at one end to the PC board, and an opposing end capped by a conductive shield, and
further including a silicone insulator on the other end of the conductive rod adapted to provide a water-tight seal between the conductive rod and the housing.

US Pat. No. 10,188,197

BACKPACK WITH EXTRACTABLE BALLISTIC PROTECTION PACKAGES

JUAN FRAILE NUEZ, Alpica...

1. An equipment having a personal protection system suitable for being carried on a user's shoulders comprising: (a) a backpack having two shoulder straps and at least one first upper compartment accessible from the outside through a first operable closing means, (b) a front ballistic package mounted with capability of being pulled out through said first closing means in said first upper compartment comprising (i) an pull-out grip at a first end and (ii) at a second end, opposite to said first end, two connecting members between said front ballistic package and said backpack, spaced apart from one other to allow for the passage of said user's head, wherein a configuration of said equipment is adjustable between (i) an undercover position in which said front ballistic package is inserted in said first upper compartment and said grip projects through said first closing means and is accessible by said user without having to remove the backpack from his shoulders and (ii) a protection position in which said front ballistic package is pulled out from said first upper compartment, facing said backpack such that it is configured for covering at least the vital organs of said user, wherein said equipment further comprises (c) compacting means which connect said front ballistic package with said backpack, such that said first upper compartment can modify the size thereof between (d) an expanded size when said equipment is in the undercover position and (e) a compacted size when said equipment is in the protection position; and wherein said first upper compartment comprises a surface near to the contact surface between said backpack and said user's back and a surface remote from said contact surface, facing said near surface, wherein said compacting means comprise at least one cable connecting said near and remote surfaces and which at least at one end is attached to said front ballistic package, said cable having a length such that when said equipment is in the protection position, said first upper compartment is in the compacted size.

US Pat. No. 10,188,183

AMBULATORY AID

Aligned As Designed, LLC,...

1. An ambulatory aid comprising:an elongate, straight shaft;
a handle coupled to a first end of the shaft at a fixed angle; and
a foot piece coupled to a second end of the shaft at a fixed angle,
wherein the first end of the shaft is coupled to the handle such that a posterior portion of the handle extends from the shaft at a length greater than an anterior portion of the handle, and the second end of the shaft is coupled to the foot piece such that an anterior portion of the foot piece extends from the shaft at a length greater than a posterior portion of the foot portion, and wherein the shaft extends at an angle between the handle and the foot piece when measured from a horizontal surface.

US Pat. No. 10,188,153

GARMENT SYSTEM FOR INTERCHANGEABLE COVERS FOR GARMENT STRAPS

STRAP APPEAL, Virginia B...

1. A bra strap cover system comprising:a bra comprising at least one shoulder strap, at least one body strap, and at least one cup, said at least one shoulder strap having a top surface, a bottom surface, a strap length, and a strap width, wherein the top surface of said at least one shoulder strap, an upper portion of the at least one cup, and a back portion of the body strap include a plurality of first fastener halves, with the first fastener halves on the top surface of said at least one shoulder strap disposed along the strap length;
at least one bra strap cover having a decorative upper face, a lower face, a cover length, and a cover width, said lower face having a plurality of second fastener halves disposed along the cover length, said cover width being greater than said strap width and wherein for a given stress, the bra strap cover has a relative strain of 0.1 or greater, relative to the shoulder strap; and
wherein the bra strap cover is configured to be removably attached to said shoulder strap by mating the plurality of first and second fastener halves together such that the bra strap cover substantially covers and overlies the top surface of said shoulder strap, and wherein the cover length when overlying the shoulder strap extends from the upper portion of the at least one cup to the back portion of the body strap so that the bra strap cover is further configured to be removably attached to the upper portion of the at least one cup to the back portion of the body strap by mating the plurality of first and second fastener halves together.

US Pat. No. 10,188,117

NOODLE STRING TREATMENT APPARATUS AND TREATMENT METHOD

NISSIN FOODS HOLDINGS CO....

1. A noodle string treatment method, comprising steps of:conveying a batch of noodle strings;
cutting the batch of noodle strings at a constant cutting time interval by using a rotary blade that has a flat shape, is attached to a rotating shaft and extends out from the rotating shaft; and
extruding the cut batch of noodle strings by the rotary blade, wherein:
a blade edge of the rotary blade extends along a direction in which the rotating shaft extends,
the rotary blade cuts the batch of noodle strings at a cutting point, which is a point where the blade edge of the rotary blade is closest to or comes into contact with an outer circumferential surface of an oppositely disposed roller,
in the step of cutting the batch of noodle strings, a blade edge peripheral speed of the rotary blade is changed during rotation thereof between a cut and a next cut,
in the step of cutting the batch of noodle strings, the batch of the noodle strings is cut at a position where a lengthwise direction of the batch of noodle strings extends in a vertical manner,
the rotary blades comprises a plurality of rotary blades attached to the rotating shaft,
in the step of cutting the batch of noodle strings, the blade edge peripheral speed of the plurality of rotary blades is changed periodically with a constant time interval over a plurality of cycles, wherein each of the plurality of cycles is a time period from one cutting timing by one of the plurality of rotary blades to a next cutting timing by another of the plurality of rotary blades cutting the batch of the noodle strings subsequent to the one of the plurality of rotary blades, and
the blade edge peripheral speed when one rotary blade among the plurality of rotary blades extrudes the cut batch of noodle strings after the one rotary blade cuts the batch of noodle strings is set to be lower than the blade edge peripheral speed of the rotary blade when the one rotary blade cuts the batch of noodle strings.
US Pat. No. 10,188,132

REFINED PLANT ISOLATES AND PROCESS FOR THE MANUFACTURE OF A FUNCTIONAL FOOD INGREDIENT FROM SUCH PLANT ISOLATE

Conopco Inc., Englewood ...

1. A process of preparing a functional food ingredient, said process comprising:a) providing an aqueous plant extract containing particles of plant material;
removing from the aqueous plant extract more than 50 vol. % of particles comprising a size of at least 2 ?m to produce a crude serum having at least 2° Brix, wherein not more than 40 vol. % of the particles in the crude serum have a diameter larger than 2 ?m;
removing Ca2+ and Mg2+ from the crude serum to produce the refined plant isolate, wherein a reduction of Ca2+ and Mg2+ in the refined plant isolate reduces a need to regenerate columns used in ion exclusion chromatography of step b)
wherein the refined plant isolate comprises:
a concentration of 40° Brix;
at least 0.2 wt % of glutamate;
at least 500 ppm of K+;
less than 300 ppm of Ca2+;
less than 700 ppm of Mg2+;
less than 1 wt. % of components incapable of passing an ultra-filtration membrane having a molecular weight cut off of 250 kDa;
a concentration ratio ([Ca2+]+[Mg2+])/[K+] that does not exceed 5:100, wherein the [Ca2+], [Mg2+] and [K+] are expressed in ppm;
wherein the concentration ratio ([Ca2+]+[Mg2+])/[K+] of the refined plant isolate is at least 2 times lower than a concentration ratio ([Ca2+]+[Mg2+])/[K+] expressed in ppm of the aqueous plant extract;
b) subjecting the refined plant isolate to ion exclusion chromatography by using columns; and
c) collecting at least a part of an eluate of the ion exclusion chromatography as the functional food ingredient or an intermediate for the process of preparing the functional food ingredient; wherein the functional food ingredient or the intermediate comprises:
at least 30% by weight of dry matter of water soluble plant components selected from fructose, glucose, proteinaceous matter of plant origin, acids and potassium;
a weight ratio glutamate:citrate of at least 5 times higher than in the refined plant isolate;
and/or a weight ratio glutamate:glucose of at least 10 times higher than in the refined plant isolate.
US Pat. No. 10,190,182

METHODS FOR ENZYME MEDIATED POLYPEPTIDE CONJUGATION

HOFFMANN LA-ROCHE INC., ...

1. A method for producing an enzymatic conjugation product of two polypeptides comprising the following stepsincubating
i) a first polypeptide comprising the amino acid sequence LPXTG (SEQ ID NO: 20, wherein X can be any amino acid residue),
ii) a second polypeptide that comprises i) an alaninyl compound at its N-terminus, or ii) an oligo-alanine Am (m =2 (SEQ ID NO: 26), or 3 (SEQ ID NO: 27), or 4 (SEQ ID NO: 28), or 5 (SEQ ID NO: 29)), or iii) a cysteine amino acid residue followed by one to three alanine amino acid residues at its N-terminus,
iii) a third polypeptide with sortase activity which is derived from Staphylococcus aureus Sortase A, and
recovering the conjugate from the reaction mixture and thereby producing the enzymatic conjugation product of two polypeptides.
US Pat. No. 10,193,005

ALL-ALUMINUM BACK SURFACE FIELD ALUMINUM PASTE FOR CRYSTALLINE SILICON SOLAR CELL AND PREPARATION METHOD THEREOF

NANTONG T-SUN NEW ENERGY ...

1. A preparation method of an all aluminum back surface field aluminum paste for a crystalline silicon solar cell, comprising the following steps:(1) preparation of inorganic binder: adding low melting point glass powder and high melting point glass powder according to a mass percentage of 1:1-2:1 into a blender mixer to mix evenly, loading the mixture into a porcelain crucible, drying for 2h in a drying oven under 160° C., then placing the mixture into a high temperature furnace to smelt for 1.5h under 500° C., performing cold-extraction on the mixture, then drying, pulverizing and screening the mixture to obtain inorganic binder;
(2) preparation of organic binder: mixing resin and organic binder according to a mass percentage of 1:1-1:4, then pouring the mixture in a dispersion machine to disperse for 30˜60 min to obtain transparent and even organic binder after the mixture is dispersed and dissolved, wherein the resin is one or several of rosin, styrax, phenolic resin, polyvinyl chloride resin, amber, shellac, polyester resin, polyamide resin and epoxy resin;
(3) preparation of aluminum paste: weighing 60-70% aluminum powder, 5-10% nanometer metal oily solution, 1-10% inorganic binder, 10-20% organic binder, 5-30% organic solvent and 1-10% accessory ingredient by total weight of the aluminum paste, and mixing evenly through the dispersion machine; and
(4) preparation of finished product: grinding the aluminum paste mixed in step (3) through a three-roll grinder to 16˜20 ?m to obtain the all-aluminum back surface field aluminum paste.
US Pat. No. 10,188,670

COMPOSITION

Phosphagenics Limited, V...

1. A method for reducing somatic cell count in a lactating subject comprising administering a formulation to the lactating subject, wherein the formulation comprises a non-neutralised tocol phosphate, a vitamin A compound, and a hydrophobic delivery vehicle,wherein the non-neutralised tocol phosphate is a combination of a non-neutralised mono-(tocopheryl) phosphate and a non-neutralised di-(tocopheryl) phosphate.
US Pat. No. 10,192,027

SYSTEMS AND METHODS FOR RNA ANALYSIS IN FUNCTIONAL CONFIRMATION OF CANCER MUTATIONS

FIVE3 GENOMICS, LLC, San...

1. A computer assisted method of treating a patient having cancer, comprising:obtaining or generating a genomic data set and a transcriptomic data set;
wherein the genomic data set includes DNA sequence data that is representative of a mutation in at least one tumor-associated gene of a diseased tissue of the patient, and wherein the mutation is relative to a normal tissue of the patient;
wherein the transcriptomic data set includes 1) RNA sequence data that is representative of the mutation in the at least one tumor-associated gene and 2) RNA expression level data of the at least one tumor-associated gene of the diseased tissue of the patient, and wherein the mutation and expression level are relative to the normal tissue of the patient;
using a sequence analysis engine to:
(a) associate the transcriptomic data set with the genomic data set using the mutation;
(b) identify the mutation as a nonsense mutation, and upon identification of the mutation as nonsense mutation to:
(c) identify a position of the mutation within the 3?-end portion of the at least one gene; and
(d) identify the expression level of the at least one gene; and
treating the patient by targeting the at least one gene when the identified position is a position in the 3-terminal portion of the gene and the identified expression level is above an expression level relative to the normal tissue.
US Pat. No. 10,188,719

CONJUGATION OF STREPTOCOCCAL CAPSULAR SACCHARIDES

GLAXOSMITHKLINE BIOLOGICA...

1. A process for preparing a conjugate of a Streptococcus agalactiae capsular saccharide and a carrier molecule, comprising the steps of:(a) oxidising a S. agalactiae capsular saccharide in order to introduce an aldehyde group into at least one terminal sialic acid residue in the saccharide;
(b) subjecting the aldehyde group to reductive amination with ammonia or a primary amine, to give a —CH2-linked amine;
(c) reacting the —CH2-linked amine with a bifunctional linker, to give an activated saccharide; and
(d) reacting the activated saccharide with a carrier molecule, thereby giving the conjugate.
US Pat. No. 10,188,725

HYBRID CORE FELINE VACCINES

Elanco US Inc., Greenfie...

1. A non-adjuvanted immunogenic composition comprising:a. Feline Rhinotracheitis virus;
b. Feline Calicivirus;
c. Virulent Systemic Feline Calicivirus; and
d. Feline Panleukopenia virus;
wherein the Feline Calicivirus and the Virulent Systemic Feline Calicivirus are inactivated; and
wherein the Feline Rhinotracheitis virus is attenuated.
US Pat. No. 10,191,034

DOSAGE REGIMEN FOR ADMINISTRATING A CD19×CD3 BISPECIFIC ANTIBODY TO PATIENTS AT RISK FOR POTENTIAL ADVERSE EFFECTS

AMGEN RESEARCH (MUNICH) G...

1. A method for treating a human patient suffering from malignant CD19-positive lymphoma or leukemia, wherein the patient is at risk for potential adverse effects resulting from treatment with a CD19×CD3 bispecific antibody comprising an amino acid sequence encoded by the nucleic acid sequence set forth in SEQ ID NO: 2 or the amino acid sequence set forth in SEQ ID NO: 1, the method comprising:(a) determining in the peripheral blood of the patient a ratio of B cells to T cells and total B cell count; and
(b) identifying the patient at risk as comprising a ratio of B cells to T cells of about 1:8 or lower;
(i) wherein a total B cell count of less than 40 B cells per microliter of peripheral blood is indicative of a higher risk for potential adverse effects for said patient; and
(ii) wherein a total B cell count of 40 B cells or greater per microliter of peripheral blood is indicative of a lower risk of potential adverse effects for said patient,
(c) administering the CD19×CD3 bispecific antibody
(i) to the patient who is at higher risk in an incremental dosage schedule to reduce the possibility of potential adverse effects in the patient,
wherein a first dose is administered for a first period of time and a second dose is consecutively administered for a second period of time,
wherein said second dose is greater than said first dose, and
wherein said second period of time exceeds said first period of time; or
(ii) to the patient who is at lower risk in a constant dose for at least four weeks.
US Pat. No. 10,188,735

COMPOSITIONS AND METHODS FOR STABILIZING PROTEIN-CONTAINING FORMULATIONS

GENENTECH, INC., South S...

1. An aqueous composition of matter comprising an antibody and an alkylglycoside having a CMC value of about 1.0 mM or greater in water at 25° C., wherein the alkylglycoside is present at a concentration that is lower than the CMC value of the alkylglycoside in water at 25° C.
US Pat. No. 10,188,991

PERMSELECTIVE ASYMMETRIC MEMBRANES

GAMBRO LUNDIA AB, Lund (...

1. A semipermeable asymmetric membrane, wherein the membrane material comprises at least one polysulfone, poly-ethersulfone, or polyarylethersulfone; and a polyvinylpyrrolidone, wherein the polyvinylpyrrolidone consists essentially of a polyvinylpyrrolidone with a weight average molecular weight Mw of more than 1,700 kDa and less than 1,900 kDa and with a number average molecular weight Mn between about 340 kDa to about 390 kDa.
US Pat. No. 10,191,062

MODEL GUT SYSTEM

University of Newcastle U...

1. An method for analysing carbohydrates, and/or triglycerides, and/or proteins, and/or lipids, or breakdown products thereof; or for simulating digestion of an edible/potable substance, the method comprising:(a) subjecting the carbohydrate, triglyceride, protein lipid, break down product or edible/potable substance to a salivary phase consisting essentially of synthetic saliva comprising an aqueous mixture of one or more salivary enzyme(s), and one or more suitable salivary diluent components at a pH in the range of from about 5 to 9;
(b) subjecting the product of (a) to a gastric phase consisting essentially of synthetic gastric juice comprising an aqueous mixture of gastric lipase, pepsin and one or more suitable gastric diluent components, at a pH from about 1.5 to about 3.5, wherein the synthetic gastric juice is added to the gastric phase at a rate of 0.1-2.5 ml/min; and
(c) subjecting the product of (b) to a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, and porcine bile, wherein the pancreatic diluent is added to the pancreatic phase at a rate of 0.1 to 2.5 ml/min.
US Pat. No. 10,188,063

LACTUCA SATIVA CULTIVAR FRAZIER

Proscreen Ag Technology, ...

1. A seed of lettuce cultivar designated FRAZIER, wherein a representative sample of seed of said cultivar was deposited under ATCC Accession No. PTA-125178.
US Pat. No. 10,190,118

METHODS AND COMPOSITIONS FOR TREATING INSECTS

ALNYLAM PHARMACEUTICALS, ...

1. A method for treating disease in an insect, the method comprising administering to the insect a composition comprising a double stranded RNA (dsRNA) molecule or a vector encoding a dsRNA molecule, and a delivery agent, wherein the dsRNA molecule is 19-24 nucleotides long, comprises a sense strand and an antisense strand, and modulates gene expression of an insect, wherein the double-stranded region of the dsRNA is about 19 nucleotides in length, andwherein the dsRNA further comprises (i) at least one mismatch, (ii) a 5?-terminal dinucleotide overhang, or a 3?-terminal dinucleotide overhang, or both a 5?- and 3?-dinucleotide overhang, and (iii) at least one asymmetrical modification, and
wherein the dsRNA molecule comprises at least one nucleotide modification to increase stabilization of the dsRNA, the modification selected from the group consisting of:
(i) a 5?-phosphorothioate or 5?-phosphorodithioate modifications within the double stranded region,
(ii) a phosphorothioate modification within the nucleotides at the terminal overhang region,
(iii) a cationic modification of nucleotides 1 and 2 on the 5? terminus, wherein the cationic modification is at the C5 position of pyrimidines and C2, C6 and C8, exocyclic N2 or exocyclic N6 of purines,
(iv) at least one 2?-fluoro modified nucleotide comprising a nucleobase modification
(v) at least one 2?-O-methyl/2?-fluoro modified nucleotide comprising a nucleobase modification,
(vi) a 5?-PuPu-3? dinucleotide at the 3? terminal of at least one of the strands in the dsRNA molecule wherein both nucleotides comprise a modified methoxyethyl (MOE) at 2?-position, and
(vii) a 5?-PuPu-3? dinucleotide at the 5? terminal of at least one of the strands in the dsRNA molecule wherein both nucleotides comprise a modified MOE at 2?-position; and
wherein modulation of the gene treats the disease.
US Pat. No. 10,190,121

APTAMERS AGAINST EGFR AND THERAPEUTIC USES THEREOF

Avvinity Therapeutics Lim...

1. A ribonucleic acid molecule comprising a nucleotide sequence:5?-mGmG mG mAfUfU fUAA fUfCmG fCfCmG fUmAmG AmAmA AmGfC mAfUmG fUfCmA AAmG fCfCmG mGmAA fCfCfC-3? (ALT102139.01) (SEQ ID NO: 79), wherein “m” represents a 2?-O-methyl substituted nucleotide and “f” represents a 2?-fluoro substituted nucleotide.
US Pat. No. 10,190,131

METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS

BASF Plant Science GmbH, ...

1. A process for producing a transgenic plant producing eicosapentaenoic acid, docosapentaenoic acid and/or docosahexaenoic acid comprising introducing into a plant:a) a nucleic acid sequence encoding a polypeptide having ?6-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 2;
b) a nucleic acid sequence encoding a polypeptide having ?6-elongase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 172;
c) a nucleic acid sequence encoding a polypeptide having ?5-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 52;
d) a nucleic acid sequence encoding a polypeptide having ?5-elongase activity, wherein said nucleic acid sequence is at least 90% identical to SEQ ID NO: 64; and
e) optionally a nucleic acid sequence encoding a polypeptide having ?4-desaturase activity, wherein said polypeptide has an amino acid sequence that is at least 95% identical to SEQ ID NO: 78;
wherein the nucleic acid sequence encoding the polypeptide having ?5-elongase activity is modified to adapt to the codon usage in one or more plant species.
US Pat. No. 10,190,135

CHIMERIC POST-TRANSCRIPTIONAL REGULATORY ELEMENT

Celltheon Corporation, U...

1. A polynucleotide comprising:(a) a first fragment consisting of the nucleic acid sequence of SEQ ID NO: 7 or a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO: 7,
(b) a second fragment consisting of the nucleic acid sequence of SEQ ID NO: 9 or a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO: 9, and
(c) a third fragment consisting of the nucleic acid sequence of SEQ ID NO: 3 or a nucleic acid sequence having at least 95% sequence identity to SEQ ID NO: 3.
US Pat. No. 10,188,611

STABLE LIQUID FILLED HARD CAPSULE COMPRISING BETA-HYDROXY-BETA METHYLBUTYRIC ACID

Capsugel Belguim NV, Bor...

1. A liquid filled hard capsule, comprising:a hard capsule shell comprising hydroxypropyl methyl cellulose; and
a liquid fill inside the hard capsule shell comprising an effective amount of beta-hydroxy-beta-methylbutyric acid (HMB free acid) in liquid form and at least one excipient selected from quaternary ammonium salts, amino acids, amino acid derivatives, fructose, and/or any mixture thereof;wherein the excipient is present from about 30% w/w to about 60% w/w of the liquid fill and the liquid filled hard capsule is physically stable.
US Pat. No. 10,188,099

HIGH DENSITY CELL BANKING METHODS

GENZYME CORPORATION, Bos...

1. A non-centrifugal method for producing a high-density frozen mammalian cell bank, the method comprising:a) culturing mammalian cells in a perfusion bioreactor to a first cell density by continuously removing growth medium from a culture and replacing with fresh growth medium, wherein the bioreactor is coupled to a cell retention system comprising an alternating tangential flow filtration system including a filter;
b) non-centrifugally concentrating the cells cultured in the perfusion bioreactor coupled to the cell retention system, wherein the cells are concentrated to a second cell density greater than the first cell density by removing the growth medium from the culture using the filter and, thereby reducing the volume of the growth medium to produce a concentrated cell population of about 1×108 cells/mL; and
c) cryopreserving the concentrated cell population to produce a high-density frozen mammalian cell bank,
wherein the high-density frozen mammalian cell bank has a post-thaw viability of at least 90%.
US Pat. No. 10,188,612

PHARMACEUTICAL COMPOSITIONS FOR INHALATION

Vectura Limited, Wiltshi...

1. Microparticles for use in a pharmaceutical composition for pulmonary administration, comprising particles of an active substance having on their surfaces particles of a hydrophobic material comprising magnesium stearate to promote the dispersal of the active particles on actuation of an inhaler or to delay the dissolution of the active substance in an aqueous medium, wherein the particles of hydrophobic material are applied to the particles of active substance experiencing a high shear force, wherein the microparticles comprise an effective amount of one or more of the substances selected from the group consisting of antimuscarinic, a ?2-agonist, a steroid, a peptide and a polypeptide, and wherein, upon inhalation of the microparticles, the active substance exerts its pharmacological effect over a period significantly greater than the period over which the active substance exerts its pharmacological effect when inhaled alone.
US Pat. No. 10,188,102

LOW FOAM SURFACTANT COMPOSITION AND METHODS OF MAKING THE SAME

Momentive Performance Mat...

1. A low foam surfactant composition comprisinga) di-trisiloxane alkoxylate component of formula (I):
(R1R2R3SiO)2(R4)Si—R5—Si(R6)(OSiR7R8R9)2  (1)
where R1, R2, R3, R4, R6, R7, R8 and R9 each independently is methyl, ethyl or linear or branched monovalent hydrocarbon radical of 3 or 4 carbon atoms,
R5 is a divalent polyalkyleneoxide group of the structure:
—(R10)aO(C2H4O)b(C3H6O)c(C4H8O)d—(R11)e—
where R10 and R11 each independently is a linear or branched divalent hydrocarbon radical of from 2 to 6 carbon atoms, a and e each independently is 0 or 1, b is 0 or greater, c is 1 or greater, and d is 0 or greater, provided that 1?b+c+d?20; and,
b) mono-trisiloxane alkoxylate component of formula (II):
(R12R13R14SiO)2Si(R15)R16  (11)
where R12, R13, R14 and R15 each independently is a linear or branched monovalent hydrocarbon radical of from 1 to 4 carbon atoms, and
R16 is a monovalent polyalkyleneoxide group of the structure:
—R17O(C2H4O)g(C3H6O)h(C4H8O)i—R18
where —R17 is a linear or branched divalent hydrocarbon radical of from 2 to 6 carbon atoms,
R18 is hydrogen, monovalent hydrocarbon radical of from 1 to 4 carbon atoms or acetyl, and g, h and i each independently is 0 or greater, provided that 1?g+h+i?15;
and, wherein di-trisiloxane alkoxylate (I) is soluble in mono-trisiloxane alkoxylate (II).
US Pat. No. 10,190,156

METHODS AND SYSTEMS FOR USING BUILT-IN STANDARD CURVE TO MEASURE MOLECULAR NUMBERS OF BIOLOGICAL COMPONENTS

W2 Biosolutions, LLC, Be...

1. A method of determining absolute quantity of at least one sample target, comprising:i) providing a solid support having a series of control partner 1 and one of at least one sample probe and at least one sample target attached thereon, wherein the series of control partner 1 and the one of the at least one sample probe and the at least one sample target are at separate locations of the solid support, and each of the series of control partner 1 has a different and known copy number;
ii) contacting the solid support with at least one control partner 2 and another of the at least one sample target and the at least one sample probe, wherein:
the series of control partner 1 are configured to recognize and bind the at least one control partner 2, resulting directly or indirectly in a series of detectable control signals, wherein an intensity of each detectable control signal correlates with the known copy number of the each of the series of control partner 1, and a copy number of each of the at least one control partner 2 is no less than the known copy number of the each of the series of control partner 1; and
the at least one sample probe is configured to recognize and bind the at least one sample target in a corresponding manner, resulting directly or indirectly in at least one detectable sample signal, wherein an intensity of each detectable sample signal correlates with a copy number of each of the at least one sample target, and a copy number of each of the at least one sample probe is no less than the copy number of the each of the at least one sample target;
iii) detecting the series of detectable control signals and the at least one detectable sample signal;
iv) making a standard curve relating the intensity of each of the series of detectable control signals with the known copy number of the each of the series of control partner 1; and
v) determining the copy number of each of the at least one sample target by using the standard curve to translate the intensity of the each of the at least one detectable sample signal to the copy number of the each of the at least one sample target.
US Pat. No. 10,188,619

SOLID SOLUTION COMPOSITIONS AND USE IN CHRONIC INFLAMMATION

Infirst Healthcare Limite...

1. A solid solution pharmaceutical composition comprising:a) one or more acetic acid derived non-steroidal anti-inflammatory drugs (NSAIDs) in an amount of about 1% to about 30% by weight of the pharmaceutical composition;
b) one or more pharmaceutically-acceptable hard fats comprising one or more glycerolipids, one or more pharmaceutically-acceptable hard fats in an amount of at least 30% by weight of the pharmaceutical composition;
c) one or more pharmaceutically-acceptable liquid lipids comprising one or more monoglycerides, the one or more pharmaceutically-acceptable liquid lipids in an amount of at least 25% by weight of the pharmaceutical composition, and
d) one or more stability agents in an amount of about 5% to about 18% by weight of the pharmaceutical composition
wherein the solid solution pharmaceutical composition is formulated to have a melting point temperature of about 25° C. or higher.
US Pat. No. 10,189,905

BISPECIFIC MOLECULE BINDING TLR9 AND CD32 AND COMPRISING A T CELL EPITOPE FOR TREATMENT OF ALLERGIES

S-TARGET THERAPEUTICS GMB...

1. A method for performing active immunotherapy for an allergic disease, comprising the step of administering to a subject therapeutically effective amount of a molecule or molecule complex comprising a TLR9 binding part capable of binding to TLR9, a CD32 binding part capable of binding to CD32, and at least one antigen,wherein the TLR9 binding part is a CpG oligodeoxynucleotide,
wherein the CD32 binding part is selected from the group consisting of an antibody and a CD32-binding antibody fragment, and
wherein the allergic disease in the subject is treated.
US Pat. No. 10,189,907

POLYNUCLEOTIDES ENCODING ANTI-KIT ANTIBODIES

Celldex Therapeutics, Inc...

1. An polynucleotide comprising nucleotide sequences encoding a VH chain region, a VL chain region, or both a VL chain region and a VH chain region, of an antibody or an antigen-binding fragment thereof, which immunospecifically binds to human KIT (SEQ ID NO: 15) and comprises:(i) a variable light (“VL”) chain region comprising a VL CDR1, VL CDR2, and VL CDR3 comprising the amino acid sequences of SEQ ID NO: 20, SEQ ID NO: 21, and SEQ ID NO: 22, respectively; and
(ii) a variable heavy (“VH”) chain region comprising a VH CDR1, VH CDR2, and VH CDR3 comprising the amino acid sequences of SEQ ID NO: 23, SEQ ID NO: 24, and SEQ ID NO: 25, respectively.
US Pat. No. 10,188,114

CONTROLLED GROWTH OF MICROORGANISMS

SYNGULON SA, Seraing (BE...

1. A method of controlling the growth of a second microbial cell, the method comprising:allowing a recombinantly engineered first microbial cell to proliferate in a culture medium being fermented by said first microbial cell and further comprising said second microbial cell, wherein said second microbial cell interferes with the fermenting of said culture medium,
said first microbial cell comprising a first nucleic acid encoding a bacteriocin operably linked to a promoter, the method further comprising expressing and secreting the bacteriocin into the culture medium, wherein the bacteriocin is selected to inhibit or prevent the reproduction of the second microbial cell,
wherein the first microbial cell has been genetically engineered to conditionally decrease or eliminate at least one of transcription, post-transcriptional expression, or post-transcriptional activity of a cell immunity modulator that confers resistance to the secreted bacteriocin in the first microbial cell, said decrease or elimination concurrent with expression of said secreted bacteriocin, thereby decreasing immunity modulator activity of said cell immunity modulator,
said second microbial cell being susceptible to the secreted bacteriocin due to an inactivity or absence of the cell immunity modulator in the second microbial cell, whereby the secreted bacteriocin inhibits or prevents the reproduction of the second microbial cell, and whereby the culture medium is fermented by the first microbial cell.
US Pat. No. 10,189,909

ANTIBODIES TO MASP-2

Helion Biotech ApS, Cope...

1. A monoclonal antibody or antigen-binding fragment thereof specifically recognising and binding a polypeptide fragment of human MASP-2 consisting of the CCP1, CCP2 and serine protease domains (aa 293 to 686 of SEQ ID NO:1), wherein said monoclonal antibody or antigen-binding fragment thereof is selected from the group consisting of:(i) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number 03050904;
(ii) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2657
(iii) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2660;
(iv) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2658; and
(v) the monoclonal antibody produced by the hybridoma cell line deposited under the deposition number DSM ACC2659,
wherein the monoclonal antibody, or antigen-binding fragment thereof, is capable of inhibiting MASP-2 catalyzed C4 deposition.
US Pat. No. 10,189,915

POLYMERIZATION PROCESS

ROHM AND HAAS COMPANY, C...

1. A method of forming a polymer, comprising(a) providing a reaction mixture comprising
(i) one or more vinyl monomers
(ii) one or more pH-sensitive inhibition systems
(iii) one or more initiators in an amount such that a weight ratio of initiator to the total of said vinyl monomers is 0.001:1 or higher,
(iv) water in an amount of 25% or more, by weight based on the total weight of the reaction mixture,
(b) establishing conditions in said reaction mixture such that a free radical polymerization of said vinyl monomer occurs at a location, and
(c) after steps (a) and (b) and prior to completion of said free radical polymerization, changing the pH of said reaction mixture to increase the rate of generation of said free radical polymerization at the location of said free radical polymerization.
US Pat. No. 10,190,175

METHOD FOR DETECTING AND IDENTIFYING ENTEROHEMORRHAGIC ESCHERICHIA COLI

Bundesinstitut Fur Risiko...

1. A method for detecting serotype(s) of enterohemorrhagic Escherichia coli (EHEC) suspected to be present in a food product, wherein said method comprises detecting the presence or the absence, in said food product or DNA isolated therefrom, of at least one of the following E. coli Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) sequences:a) CRISPR sequences for detecting EHEC O157:[H7] wherein said CRISPR sequences are selected among
the CRISPR sequences SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3, wherein the presence of one or more of said CRISPR SEQ ID NO: 1-3 is indicative of the presence of EHEC O157:[H7]; and/or
the CRISPR sequence SEQ ID NO: 4, wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O157:[H7];
b) a CRISPR sequence for detecting EHEC O145:[H28], wherein said CRISPR sequence is the sequence SEQ ID NO: 5, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O145:[H28]; and
c) a CRISPR sequence for detecting EHEC O111:[H8], wherein said CRISPR sequence is the sequence SEQ ID NO: 6, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O111:[H8]; and
d) a CRISPR sequence for detecting EHEC O121:[H19], wherein said CRISPR sequence is the sequence SEQ ID NO: 7, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O121:[H19]; and
e) a CRISPR sequence for detecting EHEC O103:[H2] and/or EHEC O45:[H2], wherein said CRISPR sequence is the sequence SEQ ID NO: 8, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O103:[H2] and/or of EHEC O45:[H2]; and
f) a CRISPR sequence for detecting EHEC O104:[H4], wherein said CRISPR sequence is the sequence SEQ ID NO: 9, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O104:[H4]; and
g) a CRISPR sequence for detecting EHEC O26:[H11], wherein said CRISPR sequence is the sequence SEQ ID NO: 10, and wherein the presence of said CRISPR sequence is indicative of the presence of EHEC O26:[H11].

US Pat. No. 10,194,487

COMMUNICATIONS PATH SELECTION IN USER EQUIPMENT

1. A multimode mobile phone comprising:a processor; and
a memory storing instructions that, when executed by the processor, cause the processor to perform operations comprising
assigning a first network identifier and a first protocol identifier to destination data corresponding to a destination device to generate a first entry associated with the destination device, wherein the first entry indicates that communications directed to the destination device are to be routed via a first network corresponding to the first network identifier using a first protocol corresponding to the first protocol identifier,
assigning a second network identifier and a second protocol identifier to the destination data corresponding to the destination device to generate a second entry associated with the destination device, wherein the second entry indicates that communications directed to the destination device are to be routed via a second network corresponding to the second network identifier using a second protocol corresponding to the second protocol identifier,
receiving an initiation of a communication directed to the destination device, and
in response to receiving the initiation of the communication directed to the destination device, selecting, from between the first entry associated with the destination device and the second entry associated with the destination device, one of the first entry associated with the destination device for connecting the multimode mobile phone with the destination device via the first network using the first protocol or the second entry associated with the destination device for connecting the multimode mobile phone with the destination device via the second network using the second protocol.

US Pat. No. 10,194,476

WI-FI DIRECT SERVICES MECHANISMS FOR WIRELESS GIGABIT DISPLAY EXTENSION

INTEL CORPORATION, Santa...

1. An apparatus, comprising:a memory; and
logic, at least a portion of which is implemented in baseband circuitry coupled to the memory, the logic to:
identify a WiGig Display Extension (WDE) service advertised by a WDE device based on a service name including an element comprising a value of either source or sink;
determine that the WDE device is to operate as a WDE source in conjunction with the WDE service when the element comprises the value source;
determine that the WDE device is to operate as a WDE sink in conjunction with the WDE service when the element comprises the value sink;
generate a Peer-to-Peer (P2P) Provision Discovery Request frame for transmission to the WDE device to initiate a procedure for establishing a P2P connection with the WDE device;
generate an Application Service Platform (ASP) REQUEST_SESSION message for transmission to the WDE device to initiate a procedure for creating an ASP session with the WDE device, the ASP REQUEST_SESSION message to comprise an advertisement ID associated with the WDE service; and
following a determination that the ASP session is open, exchange WDE protocol data with the WDE device via the P2P connection.

US Pat. No. 10,194,460

USER EQUIPMENT, NETWORK SIDE DEVICE, AND METHOD FOR SENDING DPCCH

Huawei Technologies Co., ...

1. A user equipment, comprising:a receiver, configured to receive indication information sent by a network side device;
a processor, configured to activate a second carrier of dual cell high speed uplink packet access (DC-HSUPA) according to the indication information, and to acquire uplink discontinuous transmission (DTX) parameters; and
a transmitter, configured to periodically send an uplink dedicated physical control channel (DPCCH) on the second carrier of the DC-HSUPA according to the indication information and the uplink DTX parameters,
wherein the indication information comprises a time point before which the transmitter is prohibited from sending the uplink DPCCH on the second carrier of the DC-HSUPA.

US Pat. No. 10,194,458

BLIND SCHEDULING APPARATUS AND METHOD IN A MOBILE COMMUNICATION SYSTEM

Samsung Electronics Co., ...

1. A method for communicating at a terminal in a communication system, the method comprising:receiving, from a higher layer, information related to an uplink resource;
identifying whether there is no data to be transmitted based on the uplink resource;
identifying a type of the uplink resource; and
determining not to generate a medium access (MAC) protocol data unit (PDU) based on identifying (i) that there is no data to be transmitted and (ii) the type of the uplink resource,
wherein the type of the uplink resource comprises a first type mapped to a cell radio network temporary identifier (C-RNTI) associated with a configured uplink grant.

US Pat. No. 10,194,455

METHOD FOR FEEDING BACK CHANNEL QUALITY INDICATOR, AND METHOD AND APPARATUS FOR SENDING RESOURCE SCHEDULING INFORMATION

Huawei Technologies Co., ...

1. A user equipment, comprising:a receiver, configured to obtain a system bandwidth, a channel quality indicator (CQI) feedback mode, and antenna port quantity information specified by a network device and sent by the network device,
a processor, configured to determine a feedback granularity of a CQI according to the system bandwidth, the CQI feedback mode, and the antenna port quantity information specified by the network device; and
a transmitter, configured to feed back the CQI to the network device according to the feedback granularity of the CQI.

US Pat. No. 10,194,454

METHOD AND SYSTEM FOR IMPLEMENTING SERVICE SCHEDULING, BASE STATION, AND USER EQUIPMENT

1. A method for implementing service scheduling, comprising:sending, by an evolved Node B, eNB, time-domain scheduling information of Single Cell-Point To Multipoint, SC-PTM, Multimedia Broadcast Multicast Service, MBMS, to User Equipment, UE, wherein
the time-domain scheduling information is used for indicating a position of a time-domain subframe where the MBMS is located,
a Physical Downlink Control Channel, PDCCH, of the time-domain subframe comprises frequency-domain scheduling information of the MBMS,
a Cyclic Redundancy Check, CRC, of the PDCCH is scrambled by using a Radio Network Temporary Identifier, RNTI, corresponding to contents in a Physical Downlink Share Channel, PDSCH, and
the MBMS is sent on the PDSCH.

US Pat. No. 10,194,453

COMMUNICATIONS DEVICE AND METHOD

SONY CORPORATION, Tokyo ...

1. A communications device comprising:a transmitter configured to transmit signals to one or more other communications devices via a wireless access interface to perform device-to-device communications,
a receiver configured to receive signals from the one or more other communications devices via the wireless access interface, and
a controller configured to control the transmitter and the receiver to transmit or to receive the signals via the wireless access interface to transmit or to receive data represented by the signals, the wireless access interface including
a scheduling region comprising a bitmap including a plurality of sections of communications resources arranged in a first grid, wherein each section of the plurality of sections in the scheduling region correspond to one bit of the bitmap, and
a plurality of sections of shared communications resources arranged in a second grid, each of the plurality of sections of shared communications resources corresponding to one of the bits of the bitmap in the scheduling region, wherein transmitting in one or more of the plurality of the sections of the scheduling region reserves one or more corresponding sections of the shared communications resources for transmitting the signals representing the data.

US Pat. No. 10,194,452

DEVICE-TO-DEVICE (D2D) CHANNEL MANAGEMENT WITH NETWORK-ASSISTED REFERENCE SIGNAL TRANSMISSION

Kyocera Corporation, Kyo...

1. A method comprising:instructing a first user equipment (UE) device to transmit a reference signal;
receiving, from a second UE device, device-to-device (D2D) channel characteristic information indicative of a D2D communication link between the first UE device and the second UE device, the D2D channel characteristic information determined from a UE device received reference signal that is the reference signal transmitted by the first UE device as received at the second UE device;
determining, from the D2D channel characteristic information, D2D transmission parameters for transmitting a D2D signal from the first UE device to the second UE device; and
transmitting the D2D transmission parameters to the first UE device.

US Pat. No. 10,194,450

METHOD FOR TRANSMITTING CONTROL INFORMATION, USER EQUIPMENT AND BASE STATION

HUAWEI TECHNOLOGIES CO., ...

1. A method for transmitting control information, comprising:obtaining a resource occupied by first uplink control information (UCI) and obtaining a resource occupied by second UCI;
performing channel encoding on the first UCI according to the resource occupied by the first UCI to obtain an encoded bit sequence of the first UCI, and performing channel encoding on the second UCI according to the resource occupied by the second UCI to obtain an encoded bit sequence of the second UCI; and
mapping the encoded bit sequence of the first UCI and the encoded bit sequence of the second UCI to a physical uplink channel, so as to transmit to a base station, wherein
the first UCI is periodic channel state information CSI and the second UCI is a hybrid automatic repeat request-acknowledgment message HARQ-ACK; or
the first UCI is periodic channel state information CSI and the second UCI is a hybrid automatic repeat request-acknowledgment message HARQ-ACK and a scheduling request SR, wherein the obtaining a resource occupied by first UCI comprises:
in a case that the periodic CSI comprises CSI of a first reporting type or CSI of a second reporting type, obtaining a resource occupied by the CSI of the first reporting type or the CSI of the second reporting type; or,
in a case that the periodic CSI comprises CSI of a first reporting type and CSI of a second reporting type, obtaining a resource occupied by the CSI of the first reporting type and discarding the CSI of the second reporting type, or obtaining a resource occupied by the CSI of the first reporting type and obtaining a resource occupied by the CSI of the second reporting type, wherein the performing channel encoding on the first UCI according to the resource occupied by the first UCI to obtain an encoded bit sequence of the first UCI and performing channel encoding on the second UCI according to the resource occupied by the second UCI to obtain an encoded bit sequence of the second UCI comprise:
in a case that the resource is the number of modulation symbols, calculating the number of encoded bits occupied by the first UCI according to the number of modulation symbols occupied by the first UCI, and calculating the number of encoded bits occupied by the second UCI according to the number of modulation symbols occupied by the second UCI; performing channel encoding on the first UCI according to the number of encoded bits occupied by the first UCI to obtain the encoded bit sequence of the first UCI, and performing channel encoding on the second UCI according to the number of encoded bits occupied by the second UCI to obtain the encoded bit sequence of the second UCI; or,
in a case that the resource is the number of encoded bits, performing channel encoding on the first UCI according to the number of encoded bits occupied by the first UCI to obtain the encoded bit sequence of the first UCI, and performing channel encoding on the second UCI according to the number of encoded bits occupied by the second UCI to obtain the encoded bit sequence of the second UCI, wherein
the number of modulation symbols occupied by the first UCI satisfies Q?CSI=Q? or Q?CSI=Q??Q?HARQ-ACK, and
the number of modulation symbols occupied by the second UCI satisfies
Q?HARQ-ACK=|Q?*(OHARQ-ACK/(OCSI+OHARQ-ACK))*?offset|, or
Q?HARQ-ACK=|Q?*(OHARQ-ACK/(OCSI+OHARQ-ACK))|, or
Q?HARQ-ACK=|(?)*Q?*(OHARQ-ACK/OCSI)|, or
Q?HARQ-ACK=|(OHARQ-ACK*((MSCPUCCH*NsymbPUCCH)/VSF)*?offset)/OCSI)|, or
Q?HARQ-ACK=NsymbHARQ-ACK*MSCPUCCH,
wherein Q? is capacity of the physical uplink channel, OHARQ-ACK is the total number of information bits of the HARQ-ACK, OCSI the total number of information bits of the periodic CSI, ?offset is a value configured semi-statically by high-layer signaling or a preset value, MSCPUCCH is the number of subcarriers allocated to the physical uplink channel, NsymbPUCCH is the number of time domain symbols, used for transmitting the UCI, of the physical uplink channel, VSF is the value of a spread spectrum coefficient, and NsymbHARQ-ACK is the number of time domain symbols used for transmitting the HARQ-ACK.

US Pat. No. 10,194,449

BASE STATION, SIGNAL SYNTHESIS METHOD, AND SIGNAL FORWARDING METHOD

PANASONIC INTELLECTUAL PR...

1. A first base station that receives signals transmitted from one terminal in cooperation with a second base station and performs synthesis processing of the received signals of the second base station and the received signals of the first base station, the first base station comprising:a determination circuit that determines that the synthesis processing is necessary in a case where there is an error in a result of decoding of the received signals of the first base station at the time of the first transmission of the terminal;
a communication circuit that transmits to the terminal a Negative Acknowledgement (NACK) indicating that there is the error in the result of decoding, and transmits to the second base station a message requesting forwarding of the received signals in a case where the synthesis processing is determined to be necessary, and receives the forwarded signals that are forwarded from the second base station at the time of retransmission of the terminal; and
a synthesis circuit that synthesizes the forwarded signals from the second base station and the received signals of the first base station in a case where the synthesis processing is determined to be necessary,
wherein the forwarded signals are obtained by synthesizing signals that have been received at the second base station from the first transmission until the current retransmission.

US Pat. No. 10,194,447

COMMUNICATION APPARATUS AND A METHOD FOR COMMUNICATION

SONY CORPORATION, Tokyo ...

1. An apparatus comprising:a selection unit configured to select a frequency band to which non-orthogonal multiple access is applied and at least one layer among a plurality of layers that are to be multiplexed in the frequency band for the non-orthogonal multiple access, as a band and a layer to be used for transmission to a terminal device; and
a notification unit configured to notify the terminal device of the frequency band and the at least one layer.

US Pat. No. 10,194,445

RESOURCE AND POWER ALLOCATION INDICATION IN BEAM-BASED ACCESS SYSTEM

FUTUREWEI TECHNOLOGIES, I...

10. A network component comprising:a memory storage comprising instructions; and
one or more processors in communication with the memory storage, wherein the one or more processors execute the instructions to:
determine, with the network component, a relative effective transmit power offset between a control beam and a data beam; and
signal, with the network component, the relative effective transmit power offset to a user equipment (UE) for use by the UE in performing automatic gain control (AGC) on a control channel and a data channel.

US Pat. No. 10,194,444

INDEXING RESOURCES FOR TRANSMISSION OF ACKNOWLEDGEMENT SIGNALS IN MULTI-CELL TDD COMMUNICATION SYSTEMS

Samsung Electronics Co., ...

1. A method for transmitting an acknowledgement signal at a user equipment in a wireless communication system, the method comprising:receiving control information including a hybrid automatic repeat request acknowledgement (HARQ-ACK) resource offset field including a HARQ-ACK resource index indicating a first resource offset in a table in which a plurality of resource offsets are mapped to a plurality of HARQ-ACK resource indexes associated with transmission of the acknowledgement signal;
determining a resource for transmitting the acknowledgement signal based on the first resource offset; and
transmitting the acknowledgement signal on the determined resource.

US Pat. No. 10,194,442

UPLINK RESOURCES FOR BEAM RECOVERY

QUALCOMM Incorporated, S...

1. A method for wireless communication at a user equipment (UE), comprising:receiving a configuration for beam recovery resources;
receiving an indication that enables or disables use of the beam recovery resources for a transmission of a beam recovery message;
monitoring reference signals for one or more active beams used to communicate with a base station;
identifying a beam failure of the one or more active beams based at least in part on the monitoring; and
transmitting, according to the received configuration, the beam recovery message to the base station using the beam recovery resources in response to the identified beam failure, wherein transmitting the beam recovery message is based at least in part on the received indication.

US Pat. No. 10,194,441

BANDWIDTH REDUCTION WITH BEAMFORMING AND DATA COMPRESSION

Nokia Solutions and Netwo...

1. A method comprising:for a given user equipment, selecting a subset of a plurality of beams based on received energies of the plurality of beams;
transmitting on a front haul link only data from the selected subset of beams; and
using the received energies of each beam of the subset of beams to compress the data prior to transmitting the compressed data on the front haul link, wherein using the received energies of each beam of the subset of beams comprises:
for each respective beam of the subset of beams, selecting from a set of pre-computed minimum gain offset values stored in a local memory, wherein each minimum gain offset value is stored with an associated energy value, one minimum gain offset value having an associated energy value that most closely corresponds with the received energy of the respective beam of the subset of beams;
compressing respective data associated with each respective beam of the subset of beams after dividing in-phase and quadrature portions of the respective data by the selected one minimum gain offset value that corresponds to the respective beam; and
sending indications of all of the selected one minimum gain offset values with the compressed data on the front haul link,
wherein the selecting of one minimum gain offset value is performed for each pair of physical resource blocks (PRBs) per beam of the subset of beams using received energy of the pair of PRBs.

US Pat. No. 10,194,440

CHANNEL RASTER DESIGN IN WIRELESS COMMUNICATIONS

QUALCOMM Incorporated, S...

1. A method for wireless communications by a user equipment (UE), comprising:determining, by the UE, an uplink channel raster for determining frequency location of an uplink channel over which to transmit uplink communications to a base station; and
transmitting, by the UE, uplink communications to the base station over the uplink channel,
wherein the uplink channel raster is shifted, in frequency, with respect to a legacy uplink channel raster of a legacy communication technology, wherein the uplink channel coexists with one or more uplink channels of the legacy communication technology in an uplink carrier.

US Pat. No. 10,194,436

WI-FI FRAMES INCLUDING FRAME EXTENSIONS

QUALCOMM Incorporated, S...

1. An apparatus for wireless communication, comprising:a processing system configured to:
generate a frame for transmitting data to one or more wireless nodes;
determine whether to include a frame extension after a data symbol in the frame;
determine a length of the frame extension, if the determination is to include the frame extension in the frame, based on an amount of data in the data symbol of the frame and on a ratio of useful coded data bits in the data symbol to total coded bits in the data symbol; and
provide an indication of the length of the frame extension within the frame, if the determination is to include the frame extension;
a first interface configured to output the frame for transmission.

US Pat. No. 10,194,434

METHOD AND APPARATUS FOR SCHEDULING OF A WIRELESS DEVICE

TELEFONAKTIEBOLAGET LM ER...

1. A network node configured for operation in a wireless communication network, said network node comprising:a communication interface configured for communicating with at least one of: another network node of a same or different type; and a wireless device operating within the wireless communication network; and
a processing circuit configured to:
determine whether the wireless device is of a first type or a second type, where wireless devices of the first type have no ability or a limited ability to transmit in a post-gap subframe, which is any uplink subframe that is the first subframe after a measurement gap that was preceded by an uplink subframe or a special subframe, whereas wireless devices of the second type have the ability, without limitation, to transmit in post-gap subframes; and
control scheduling of the wireless device with respect to post-gap subframes, in dependence on whether the wireless device was determined to be of the first type or of the second type.

US Pat. No. 10,194,430

METHOD AND APPARATUS FOR TRANSMITTING UPLINK CONTROL INFORMATION IN A WIRELESS COMMUNICATION SYSTEM

LG ELECTRONICS INC., Seo...

1. A method for transmitting uplink control information (UCI), performed by a user equipment (UE), in a wireless communication system, the method comprising:determining a transmission power of a physical uplink control channel (PUCCH); and
transmitting the UCI to a base station (BS) through the PUCCH using the transmission power of the PUCCH in a subframe,
wherein when the subframe is configured for transmitting a scheduling request (SR) and when a transmission of a hybrid automatic repeat request-acknowledgement (HARQ-ACK) coincides with the subframe, the transmission power of the PUCCH is determined based on a total payload size of the HARQ-ACK and the SR, and
wherein a payload size of the SR is one bit.