US Pat. No. 10,392,679

METHOD FOR RECOVERING GOLD FROM ACTIVATED CARBON

1. A method for eluting gold from an activated carbon on which at least sulfur (S) and gold (Au) are adsorbed, wherein the activated carbon is washed with an alkali solution to remove sulfur (S) before eluting the gold, and then the gold is eluted from the activated carbon.
US Pat. No. 10,392,423

PEPTIDE-BASED INHIBITORS OF MLL/SET1 FAMILY CORE COMPLEXES

The Research Foundation f...

1. A peptide that inhibits the formation of or disrupts MLL1 and SET1 complexes, wherein the peptide is 6-50 amino acid long and comprises the following sequence: ARX1X2X3X4 (SEQ ID NO:1), wherein X1 is A, S, L, V, W, Y, or T; X2 is E or Q; X3 is V, P, or G; and X4 is Y, K, or R, and wherein the N-terminus of the peptide is acetylated or the C-terminus is amidated.
US Pat. No. 10,391,142

BIOMARKERS FOR PAINFUL INTERVERTEBRAL DISCS AND METHODS OF USE THEREOF

The Regents of the Univer...

1. A method of treating a painful intervertebral disc in an individual, the method comprising:a) detecting the painful intervertebral disc, wherein said detecting comprises assaying for an expression level of a gene product of a pain indicator gene, wherein the pain indicator gene is phospholipase A2 (PLA2),
wherein a decreased expression level of a PLA2 gene product in an intervertebral disc tissue, compared to a nonpainful degenerated disc reference sample, indicates that the intervertebral disc is painful; and
b) administering an effective amount of a tumor necrosis factor-alpha induced protein 6 (TSG6) polypeptide, wherein the TSG6 polypeptide comprises an amino acid sequence having at least 95% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:1.
US Pat. No. 10,392,682

STEEL SHEET FOR THREE-PIECE CAN AND METHOD FOR MANUFACTURING THE SAME

JFE Steel Corporation, T...

1. A steel sheet for a three-piece can, the steel sheet having a chemical composition consisting of, by mass %, C: 0.0005% or more and 0.0035% or less, Si: 0.050% or less, Mn: 0.63% or more and 1.00% or less, P: 0.030% or less, S: 0.020% or less, Al: 0.010% or more and 0.100% or less, N: 0.0030% or less, B: 0.0005% or more, and the balance being Fe and inevitable impurities, wherein:the relationship B/N?0.50 is satisfied (where B/N represents (B(mass %)/10.81)/(N(mass %)/14.01));
a Young's modulus in a direction at an angle of 90° to a rolling direction is 220 GPa or more;
a Lankford value in the direction at the angle of 90° to the rolling direction is less than 1.00; and
an average ferrite grain size in the steel sheet is 10.0 ?m or less.
US Pat. No. 10,392,427

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST LUNG CANCER, INCLUDING NSCLC, SCLC AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has lung cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells that present a peptide consisting of the amino acid sequence of YPKDIYSSF (SEQ ID NO: 223).
US Pat. No. 10,391,146

METHOD TO FUNCTIONALIZE CELLS IN HUMAN BLOOD, OTHER FLUIDS AND TISSUES USING NANOPARTICLES

Cornell University, Itha...

1. A method of killing metastatic cancer cells comprising:a) providing nanoparticles which are functionalized with antibodies to CD57 and therapeutic molecules selected from the group consisting of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and Fas ligand, wherein the antibodies to CD57 on the nanoparticles bind to CD57 on NK-1 cells in circulation, and wherein the TRAIL interacts with DR4 and DR5 receptors, and the Fas ligand interacts with Fas on cancer cells causing apoptosis of the cancer cells; and
b) introducing the nanoparticles into the circulation of an individual in need of treatment thereby allowing the nanoparticles to bind to the NK-1 cells and the NK-1 cells to seek out cancer cells thereby causing the nanoparticles to interact with the cancer cells via the therapeutic molecules causing cell death of the cancer cells.
US Pat. No. 10,392,430

METHODS OF MAKING NUCLEIC ACID MOLECULES ENCODING MODIFIED CHIMERIC POLYPEPTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES

REGENERON PHARMACEUTICALS...

1. A method for making a nucleic acid molecule encoding a chimeric VEGF-binding fusion protein with improved pharmacokinetic properties, the method comprising: modifying a nucleic acid molecule encoding immunoglobulin (“Ig”) domains 1, 2 and 3 of Flt1 fused to an Fc domain (“Flt1(1-3)-Fc”), wherein said modifying comprises: (a) deleting the nucleotide sequence encoding the first Ig domain of Flt1; and (b) replacing the nucleotide sequence encoding the third Ig domain of Flt1 with the nucleotide sequence encoding the third Ig domain of Flk1 or Flt4;thereby making a nucleic acid molecule encoding a chimeric VEGF-binding fusion protein with reduced binding to extracellular matrix (ECM) and improved pharmacokinetics (PK) as compared to Flt1(1-3)-Fc.
US Pat. No. 10,395,759

METHODS AND SYSTEMS FOR COPY NUMBER VARIANT DETECTION

REGENERON PHARMACEUTICALS...

1. A method comprising:receiving, by a computing device, a sample coverage data set comprising a plurality of genomic sequences obtained from sequencing of nucleic acid samples of a subject, and sample sequencing quality control (SSQC) metrics;
grouping, by the computing device, sets of sequencing quality control (SQC) metrics into a multidimensional tree data structure according to similarity, wherein each set of SQC metrics is associated with a respective reference coverage data set that comprises a plurality of genomic regions and read depths;
selecting, by the computing device, a reference panel of reference coverage data sets using the multidimensional tree data structure, wherein the selected reference coverage data sets have SQC metrics similar to the SSQC metrics;
normalizing, by the computing device, the sample coverage data set and the reference panel;
fitting, by the computing device, the normalized reference panel to a mixture model at each of the plurality of genomic regions to determine an expected coverage distribution at each of the plurality of genomic regions; and
identifying one or more copy number variants (CNVs) by comparing, by the computing device, according to a Hidden Markov Model (HMM), the normalized sample coverage data set to the expected coverage distribution at each of the plurality of genomic regions from the mixture model.
US Pat. No. 10,392,431

POLYNUCLEOTIDE ENCODING IL-35 RECEPTOR

1. An isolated polynucleotide or mixture of polynucleotides, comprising:(a) a first polynucleotide sequence encoding the extracellular domain of the polypeptide sequence set forth in SEQ ID NO:3, wherein the first polynucleotide is operably linked to a first heterologous regulatory sequence; and
(b) a second polynucleotide sequence encoding the extracellular domain of the polypeptide sequence set forth in SEQ ID NO:6, wherein the second polynucleotide is operably linked to a second heterologous regulatory sequence.
US Pat. No. 10,392,690

METHOD FOR SYNTHESIZING A THIN FILM STAINLESS STEEL COATING

Kuwait Institute for Scie...

1. A method for synthesizing a thin film stainless steel coating, comprising:using electron-beam PVD coating to provide a thin film stainless steel coating on a target surface, the electron-beam PVD coating comprising conducting thermal evaporation of a source stainless steel material at a percentage of electron beam power ranging from about 3% to about 4% and a vacuum pressure of 6×10?6 Torr, wherein the source stainless steel material comprises a plurality of stainless steel balls, further wherein the source stainless steel material has a first grade and the thin film stainless steel coating has a second grade that is different from the first grade, wherein the second grade includes predetermined percentages of Fe, Ni, Mn, Mo, and Cr; and
the thin film stainless steel coating has a uniform thickness of from 1 nm to 150 nm distributed uniformly on the target surface.
US Pat. No. 10,391,159

METHODS AND MATERIALS FOR TREATING CANCER

Mayo Foundation for Medic...

1. A method of treating cancer within a mammal, wherein said method comprises administering to said mammal a composition comprising nucleic acid encoding an HIF-2? antigen, a SOX-10 antigen, and a C-MYC antigen, wherein said composition comprises less than 100 separate nucleic acid molecules.
US Pat. No. 10,392,442

USE OF ANTI-PD-1 ANTIBODY IN COMBINATION WITH ANTI-CD27 ANTIBODY IN CANCER TREATMENT

Bristol-Myers Squibb Comp...

1. A method for treating a subject afflicted with a tumor comprising administering the subject in need thereof an antibody or an antigen-binding portion thereof that binds specifically to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity (“an anti-PD-1 antibody”) in combination with varlilumab, wherein the anti-PD-1 antibody is selected from the group consisting of nivolumab, pembrolizumab, MEDI0680, and BGB-A317.
US Pat. No. 10,391,418

APPARATUS FOR VACUUM PURIFICATION

Merck Patent GmbH, Darms...

1. Apparatus for the sublimation of chemical compounds, comprising an oven (1), a sublimer unit (2), a condensation unit (3), which is in contact with the sublimer unit, a rotation drive (4) for rotation of the sublimer and condensation units, and a vacuum pump or vacuum-pump system (6), characterised in that the apparatus has, between the rotating part and the fixed part, a rotation coupling (5), which is selected from a rotary feedthrough with ferrofluidic seal or a double- or triple-acting mechanical face seal.
US Pat. No. 10,391,163

BIRD FLU VACCINE COMBINATION COMPRISING VIRUS-LIKE PARTICLES AND NOVEL ADJUVANTS

Academia Sinica, Taipei ...

1. An adjuvanted influenza vaccine composition with adjuvants, comprising:(a) an influenza virus-like particle (VLP) a therapeutically effective amount against influenza infection, comprising:
(i) influenza M1, influenza M2, influenza hemagglutinin (HA), and influenza neuraminidase (NA) proteins; and
(b) the adjuvants, comprising:
(1) a recombinant capsid VP3 protein (rVP3) of foot-and-mouth disease virus; and
(2) alum.
US Pat. No. 10,391,676

FIBER-REINFORCED MULTILAYERED PELLET, MOLDED ARTICLE MOLDED THEREFROM, AND METHOD OF PRODUCING FIBER-REINFORCED MULTILAYERED PELLET

Toray Industries, Inc., ...

1. A fiber-reinforced multilayered pellet comprising:a sheath layer; and
a core layer,
the sheath layer comprising a resin composition comprising a thermoplastic resin (a1) and a fibrous filler (b1), wherein the fibrous filler (b1) has a weight-average fiber length (Lw) of 0.1 mm to less than 0.5 mm and a weight-average fiber length/number-average fiber length ratio (Lw/Ln) of 1.0 to less than 1.8,
the core layer comprising a resin composition comprising a thermoplastic resin (a2) and a fibrous filler (b2), wherein the fibrous filler (b2) has a weight-average fiber length (Lw) of 0.5 mm to less than 15.0 mm and a weight-average fiber length/number-average fiber length ratio (Lw/Ln) of 1.8 to less than 5.0.
US Pat. No. 10,392,445

TUMOR NECROSIS FACTOR (TNF) FAMILY LIGAND TRIMER-CONTAINING ANTIGEN-BINDING MOLECULES

Hoffmann-La Roche Inc., ...

1. A tumor necrosis factor (TNF) family ligand trimer-containing antigen-binding molecule comprising(a) at least one antigen-binding domain comprising an antibody light chain variable region (VL) and an antibody heavy chain variable region (VH) capable of specific binding to a target cell antigen wherein the target cell antigen is Fibroblast Activation Protein (FAP) and
(b) a first and a second polypeptide that are linked to each other by a disulfide bond,
wherein the first polypeptide comprises two ectodomains of a TNF ligand family member or a fragment thereof that are connected to each other by a peptide linker and the second polypeptide comprises only one ectodomain of the TNF ligand family member or a fragment thereof, wherein the TNF ligand family member is 4-1BBL and wherein the antigen-binding molecule activates the NF?B signaling pathway.
US Pat. No. 10,395,776

SYSTEMS AND METHODS FOR AUTOMATICALLY DETERMINING MYOCARDIAL BRIDGING AND PATIENT IMPACT

HeartFlow, Inc., Redwood...

1. A computer-implemented method for determining or predicting systolic compression of a patient, the method comprising:receiving one or more patient-specific images of a patient's heart;
computationally generating a patient-specific model using the one or more received patient-specific images, the patient-specific model representing at least a portion of the patient's myocardium and an epicardial coronary artery of the patient;
computationally detecting, in the patient-specific model, a segment of the epicardial coronary artery that is inside, at least partially surrounded by, or adjacent to a surface of the modeled myocardium;
computing systolic compression of the segment of the epicardial coronary artery that is inside, at least partially surrounded by, or adjacent to a surface of the modeled myocardium;
determining one or more patient-related hemodynamic characteristics associated with the patient;
determining and storing an association between the computed systolic compression of the segment and the one or more patient-related hemodynamic characteristics;
receiving one or more hemodynamic characteristics associated with an individual;
determining a systolic compression associated with the individual's coronary artery, based on the one or more received hemodynamic characteristics associated with the individual and the association between the computed systolic compression and the one or more patient-related hemodynamic characteristics.
US Pat. No. 10,392,448

METHOD FOR GRAFTING A CARBOXYLIC ACID ESTER FUNCTION ONTO AN UNSATURATED POLYMER

COMPAGNIE GENERALE DES ET...

1. A composition which comprises a filler and a polymer obtained by synthesizing an unsaturated polymer comprising at least one carboxylic acid ester function along the polymer chain, which comprises reacting a 1,3-dipolar compound with at least one unsaturation of an unsaturated polymer, which 1,3-dipolar compound comprises a group Q and a group B connected to one another by a group A in which:Q comprises a dipole containing at least one nitrogen atom,
B represents a carboxylic acid ester function, and
A is an atom or a group of atoms connecting Q to B.
US Pat. No. 10,395,777

METHOD AND SYSTEM FOR CHARACTERIZING MICROORGANISM-ASSOCIATED SLEEP-RELATED CONDITIONS

1. A method for characterizing a sleep-related condition associated with microorganisms, the method comprising:determining a microorganism sequence dataset associated with a set of subjects, based on microorganism nucleic acids from samples associated with the set of subjects, wherein the microorganism nucleic acids are associated with the sleep-related condition;
collecting, for the set of subjects, supplementary data associated with the sleep-related condition;
determining at least one of a set of microbiome composition features and a set of microbiome functional features associated with the set of subjects, based on the microorganism sequence dataset;
generating a sleep-related characterization model based on the supplementary data and the at least one of the set of microbiome composition features and the set of microbiome functional features, wherein the sleep-related characterization model is associated with the sleep-related condition;
determining a sleep-related characterization for a user for the sleep-related condition based on the sleep-related characterization model; and
providing a therapy to the user for facilitating improvement of the sleep-related condition, based on the sleep-related characterization.
US Pat. No. 10,392,706

GALVANIZED STEEL SHEET AND METHOD FOR PRODUCING THE SAME

JFE STEEL CORPORATION, T...

1. A galvanized steel sheet comprising a steel sheet and a galvanized coating layer formed on the steel sheet,wherein the coating layer includes an oxide layer in a surface layer, the oxide layer having an average thickness of 20 nm or more, and
the oxide layer comprises Zn, O, H, S, C, P, and unavoidable impurities, and contains 50 mg/m2 or more of Zn, 5 mg/m2 or more of S, 0.2 mg/m2 or more of C, and 0.2 mg/m2 or more of P.
US Pat. No. 10,391,169

METHOD OF TREATING ALLERGIC ASTHMA WITH ANTIBODIES TO IL-6

ALDERBIO HOLDINGS LLC, L...

1. A method of treating allergic asthma by administering an effective dosage of an anti-IL-6 antibody or IL-6 binding antibody fragment comprising a variable light chain polypeptide having CDRs of SEQ ID NO:4, 5 and 6 and a variable heavy chain polypeptide having CDRs of SEQ ID NO:7, 8 or 120, and 9.
US Pat. No. 10,392,708

METALIZED PLASTIC ARTICLES AND METHODS THEREOF

BYD COMPANY LIMITED, She...

1. A plastic article comprising: a plastic substrate having a plastic, at least one accelerator, and at least a first and a second metal layers plated on the at least one accelerator, the accelerator having a formula ABO3, wherein A is one or more elements selected from Groups 9, and 10 of the Periodic Table of Elements, B includes one or more elements selected from Groups 4B and 5B of the Periodic Table of Elements, and O is oxygen.
US Pat. No. 10,393,732

METHOD OF SCREENING A DRUG SUCH AS INSULIN SECRETAGOGUE

JNC Corporation, Tokyo (...

1. A polynucleotide encoding a fusion protein of preproinsulin and a luciferase,wherein the luciferase is Gaussia luciferase, and
wherein Gaussia luciferase is a protein selected from the group consisting of (a) through (c) below:
(a) a protein comprising the amino acid sequence of SEQ ID NO: 8;
(b) a protein consisting of an amino acid sequence comprising deletion, substitution, insertion and/or addition of 1-10 amino acid residues in the amino acid sequence of SEQ ID NO: 8, and having substantially the same activity as a protein consisting of the amino acid sequence of SEQ ID NO: 8; and
(c) a protein consisting of an amino acid sequence having at least 90% identity to the amino acid sequence of SEQ ID NO: 8, and having substantially the same activity as a protein consisting of the amino acid sequence of SEQ ID NO: 8; and
wherein the preproinsulin consists of a signal peptide of preproinsulin and the polypeptide selected from the group consisting of (i) through (k) below:
(i) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 4;
(j) a polypeptide comprising a polypeptide consisting of an amino acid sequence comprising deletion, substitution, insertion and/or addition of 1-10 amino acid residues in the amino acid sequence of SEQ ID NO: 4, and having substantially the same activity as the polypeptide consisting of the amino acid sequence of SEQ ID NO: 4; and
(k) a polypeptide comprising a polypeptide consisting of an amino acid sequence having at least 90% identity to the amino acid sequence of SEQ ID NO: 4, and having substantially the same activity as the polypeptide consisting of the amino acid sequence of SEQ ID NO: 4; and
wherein the signal peptide of preproinsulin is a polypeptide consisting of the amino acid sequence of SEQ ID NO: 6.
US Pat. No. 10,392,452

LIGHT GENERATING MICROCAPSULES FOR SELF-HEALING POLYMER APPLICATIONS

International Business Ma...

1. A self-healing polymeric material comprising:a polymeric matrix material;
a plurality of monomer mixture microcapsules dispersed in the polymeric matrix material, each monomer mixture microcapsule of the plurality of monomer mixture microcapsules encapsulating a mixture of materials that includes monomers and a photoinitiator; and
a plurality of light generating microcapsules dispersed in the polymeric matrix material, each light generating microcapsule of the plurality of light generating microcapsules encapsulating multiple reactants that undergo a chemiluminescent reaction, wherein each light generating microcapsule comprises an outer shell and an inner shell,
wherein the chemiluminescent reaction generates a photon having a wavelength within a particular emission range that is consistent with an absorption range of the photoinitiator and wherein the chemiluminescent reaction occurs without rupture of the outer shell of the light generating microcapsules.
US Pat. No. 10,392,453

PRODUCTION METHOD FOR OLEFIN-POLYMERIZATION CATALYST AND PRODUCTION METHOD FOR OLEFIN POLYMER

TOHO TITANIUM CO., LTD., ...

1. A method for producing an olefin polymerization catalyst comprising bringing a solid catalyst component for olefin polymerization, a vinylsilane compound, an organosilicon compound, and an organoaluminum compound into contact with each other in an inert organic solvent under an inert gas atmosphere in the absence of a compound represented by a general formula (I), wherein a washing treatment is not performed after the vinylsilane compound has been added to a reaction system, the solid catalyst component comprises a magnesium compound, a titanium halide compound, and an electron donor compound that does not comprise a phthalic acid ester structure, and comprises a diol skeleton, and the organosilicon compound does not comprise a vinyl group, and comprises at least one group selected from an alkoxy group and an amino group,CH2?CH—R1  (I)
wherein R1 is a hydrogen atom or a hydrocarbon residue having 1 to 20 carbon atoms,
wherein the vinylsilane compound is a compound represented by a general formula (II),
(CH2?CH—)SiR2R3R4(II)
wherein R2, R3, and R4 are independently a halogen atom, or a group selected from a group derived from a saturated hydrocarbon compound having 1 to 10 carbon atoms, a group derived from a halogen-containing saturated hydrocarbon compound having 1 to 10 carbon atoms, a group derived from an aromatic hydrocarbon compound having 6 to 20 carbon atoms, and a group derived from a halogen-containing aromatic hydrocarbon compound having 6 to 20 carbon atoms, provided that R2, R3, and R4 are either identical to or different from each other.
US Pat. No. 10,392,710

BRIGHTENING AND PASSIVATION OF STAINLESS STEEL SURFACES

1. A passivating and brightening aqueous composition, comprising water and the following dissolved components:(A) at least one acid which does not contain fluorine;
(B) at least one fluorine containing inorganic compound;
(C) at least one substance containing a peroxy moiety; and
(D) at least one organic polyol compound containing more than two hydroxyl groups with at least 3, but not more than 8 carbon atoms.
US Pat. No. 10,393,735

PROCESSING OF FLUIDS CONTAINING INTERFERING PARTICLES

KONINKLIJKE PHILIPS N.V.,...

1. A device for processing a fluid containing interfering particles (C), the device comprising:a processing chamber containing the fluid and magnetic particles (MP, MPB), the processing chamber comprising a blocking zone (BZ, BZ?) formed by distribution of the magnetic particles for physically imped the interfering particles to filter out and control distribution of the interfering particles within the processing chamber during the processing of the fluid to alter interference caused by the interfering particles; and
a magnetic field generator for generating a magnetic field that provides, at least in part, the distribution of the magnetic particles (MP, MPB) forming the blocking zone (BZ, BZ?) within the processing chamber,
wherein the mean distance between the magnetic particles (MP, MPB) and/or clusters (CL) of the magnetic particles of the blocking zone (BZ, BZ?) is less than or equal to about five times the mean diameter of the interfering particles (C).
US Pat. No. 10,391,173

ANTI-AR AGENT AND RADIATION THERAPY FOR ANDROGEN RECEPTOR POSITIVE CANCER

THE CLEVELAND CLINIC FOUN...

1. A method of treating cancer comprising:a) determining that a subject has androgen receptor positive breast cancer cells;
b) treating said subject with an anti-androgen receptor agent under conditions such that at least some or most or all of said androgen receptor positive cancer cells are sensitized to radiation therapy; and
c) treating said subject with radiation therapy, wherein said radiation therapy is performed at least 1 hour after said treating with said anti-androgen receptor agent, and wherein said treating causes at least a portion of said androgen receptor positive cancer cells to die.
US Pat. No. 10,392,712

CHEMICAL INHIBITION OF PITTING CORROSION IN METHANOLIC SOLUTIONS CONTAINING AN ORGANIC HALIDE

Baker Hughes, a GE compan...

1. A methanolic solution comprising:water;
methanol;
at least one organic halide; and
at least one compound selected from the group consisting of organic hydroxyacids containing 2 to 10 carbon atoms with at least one hydroxyl group and at least one carboxylic acid group, and alkaline metal salts thereof, and amine salts thereof, and combinations thereof; where:
the methanol proportion ranges from about 5 to about 60 wt %;
the at least one organic halide proportion ranges from about 0.5 to about 70 wt %; and
the at least one compound proportion ranges from about 0.5 to about 10 wt %.
US Pat. No. 10,392,457

METHOD OF PREPARING THERMOPLASTIC RESIN

LG CHEM, LTD., Seoul (KR...

1. A method of preparing a styrene acrylonitrile (SAN) resin, the method comprising:a coagulation step of adding a water-soluble silicate compound and a metal salt coagulant to an ?-methylstyrene-vinyl cyan compound copolymer latex, followed by coagulation;
an aging step after the coagulation step; and
drying the coagulated copolymer latex to form a powder of particles having an average diameter of 500 to 700 microns,
wherein the coagulation step is carried out at a temperature of greater than 80° C., and the aging step is carried out at 110° C. or more.
US Pat. No. 10,391,176

COMPOSITION, ITS PREPARATION AND METHOD OF USE IN TREATING SKIN DISORDERS

1. A composition comprising:a. zafirlukast;
b. a first and a second polyethylene glycol;
c. (a nonionic hydrophilic ester) PEG 6 caprylic/capric glycerides;
d. an alcohol; and
e. an antioxidant.
US Pat. No. 10,392,461

MODIFIED POLYOLEFIN PARTICLES AND METHODS FOR PRODUCING THE SAME

MITSUI CHEMICALS, INC., ...

1. Modified polyolefin particles obtained by grafting a monomer having an ethylenically unsaturated group and a polar functional group in the same molecule to a polymer including one, or two or more ?-olefins selected from C2-18 ?-olefins and having a melting point of not less than 50° C. and less than 250° C., the modified polyolefin particles having an average particle size of 0.2 mm to 10 mm and satisfying the following requirements (1) to (3):(1) the amount of grafting x by the monomer having an ethylenically unsaturated group and a polar functional group in the same molecule is not less than 0.5 wt % and not more than 20 wt %;
(2) the amount of grafting x (wt %) by the monomer having an ethylenically unsaturated group and a polar functional group in the same molecule, and the intrinsic viscosity [?] (dl/g) measured in decalin at 135° C. satisfy the relation:
log10[?]?0.1-0.15x; and
(3) the modified polyolefin particles have a gel content of less than 1 wt %;
wherein the gel content is determined by placing approximately 0.3 g of the modified polyolefin particles into a 330 mesh metal gauge, adding 100 ml of xylene to the modified polyolefin particles in the gauge, heating the mixture under reflux for 2 hours, and calculating a ratio of the weight of undissolved components retained in the metal gauge to the weight of the whole of the modified polyolefin particles, and is obtained as the ratio.
US Pat. No. 10,392,463

ACRYLIC RESIN COMPOSITION, AND MOLDED PRODUCT AND FILM MADE FROM SAME

KANEKA CORPORATION, Osak...

1. A resin composition comprising:an acrylic resin; and
a graft copolymer having a gel content of 65 to 84%,
wherein the graft copolymer comprises:
a first hard polymer comprising 40 to 100 wt % of a methacrylate ester unit (a-1), 60 to 0 wt % of a monomer unit (a-2) having a double bond copolymerizable with the methacrylate ester unit, and 0.01 to 10 parts by weight of a polyfunctional monomer unit per 100 parts by weight of a total amount of (a-1) and (a-2),
a soft polymer comprising 60 to 100 wt % of an acrylate ester unit (b-1), 0 to 40 wt % of a monomer unit (b-2) having a double bond copolymerizable with the acrylate ester unit, and 0.1 to 5 parts by weight of a polyfunctional monomer unit per 100 parts by weight of a total amount of (b-1) and (b-2); and
a second hard polymer comprising 60 to 100 wt % of a methacrylate ester unit (c-1),
40 to 0 wt % of a monomer unit (c-2) having a double bond copolymerizable with the methacrylate ester unit, and 0 to 10 parts by weight of a polyfunctional monomer unit per 100 parts by weight of a total amount of (c-1) and (c-2),
wherein at least a part of the first hard polymer is coated with the soft polymer,
wherein the second hard polymer is grafted on the first hard polymer and/or the soft polymer, and
wherein the first hard polymer has a primary alkylthio group and/or a secondary alkylthio group.
US Pat. No. 10,391,694

METHOD OF PRODUCING FILM

KANEKA CORPORATION, Osak...

1. A method of producing a film, the method comprising:melting and kneading a thermoplastic resin composition having a relaxation modulus of not less than 100 Pa and not more than 1500 Pa, the relaxation modulus being measured under conditions of a temperature of 260° C., distortion of 1%, and a relaxation time of 1 second; and
performing extrusion molding of the thermoplastic resin composition using a T die to form the film,
wherein the thermoplastic resin composition contains an acrylic resin and a rubber particle.
US Pat. No. 10,392,464

THERMOPLASTIC RESIN, METHOD OF PREPARING THERMOPLASTIC RESIN, AND THERMOPLASTIC RESIN COMPOSITION INCLUDING THERMOPLASTIC RESIN

LG CHEM, LTD., Seoul (KR...

1. A thermoplastic resin, comprising: a core prepared by graft-polymerizing 40 to 70% by weight of a conjugated diene rubbery polymer with 7.5 to 30% by weight of a total of monomers comprising an aromatic vinyl compound and a vinyl cyanide compound; and a shell enclosing the core and prepared by graft-polymerizing the conjugated diene rubbery polymer with 15 to 45% by weight of a total of monomers comprising an aromatic vinyl compound and a vinyl cyanide compound,wherein the vinyl cyanide compound of the monomers constituting the core is comprised in an amount of 0.01 to 20% by weight based on 100% by weight of a total of the monomers of the core, and
the vinyl cyanide compound of the monomers constituting the shell is comprised in an amount of greater than 25% by weight to 90% by weight or less based on 100% by weight of a total of the monomers of the shell,
wherein the conjugated diene rubbery polymer is a mixture of a rubbery polymer (A) having a gel content of 60 to 75% by weight and a rubbery polymer (B) having a gel content of 80 to 95% by weight.
US Pat. No. 10,391,183

INFECTIVITY-ENHANCED CONDITIONALLY-REPLICATIVE ADENOVIRUS AND USES THEREOF

The UAB Research Foundati...

1. A method of providing adenoviral gene therapy to an individual having a cancer comprising tumor cells, the method comprising the steps of:directly administering to the tumor cells a therapeutic dose of an infectivity-enhanced conditionally-replicative adenovirus, wherein said infectivity-enhanced conditionally-replicative adenovirus possesses a modification or a replacement within the fiber protein that leads to enhanced infectivity of the tumor cells as compared to the infectivity of the tumor cells by a wild-type adenovirus without the modification or the replacement, and an early gene whose expression mediates the conditional replication of said infectivity-enhanced conditionally-replicative adenovirus in said tumor cells, wherein said adenovirus has a genome comprising an E1A deletion limited to the 24 nucleotides encoding amino acids 122 to 129 of the adenoviral E1A protein, but otherwise contains all other wild-type E1A nucleotides, and wherein said early gene is conditionally regulated by means selected from the group consisting of a tissue-specific promoter operably linked to said early gene and a mutation in said early gene.
US Pat. No. 10,391,440

METHOD FOR PRODUCING OXYGEN BY VPSA

1. A process for the production of oxygen by adsorption of a stream of atmospheric air employing VPSA comprising at least one adsorber, each adsorber being subjected to the same pressure cycle comprising the following stages:a) production of a first gas stream comprising an oxygen content C1 while charging upstream the adsorber with the stream of atmospheric air,
b) production of a second gas stream comprising an oxygen content C2 c) production of a third gas stream comprising an oxygen content C3 d) elution of the adsorber, from which have emerged the three gas streams produced in stages a), b) and c), with the second gas stream produced in stage b),
e) repressurization of the adsorber which has been subjected to the elution of stage d) with successively at least two streams, a first and a second repressurization stream, having an increasing oxygen content, the first repressurization stream being the third gas stream produced in stage c) and the second repressurization stream being the second gas stream produced in stage b).
US Pat. No. 10,392,466

TWO-COMPONENT POLYURETHANE ADHESIVE COMPOSITION

3M Innovative Properties ...

1. A curable two-component polyurethane adhesive composition comprising:a first component C1 comprising at least one polyol;
a second component C2 comprising at least one isocyanate; and
a polyurethane catalytic system comprising a first bicyclic amine and a second bicyclic amine, wherein the first bicyclic amine is selected to be 1,8-diazabicyclo[5.4.0]undec-7-ene and the second bicyclic amine is selected to be 1,4-diazabicyclo[2.2.2]octane.
US Pat. No. 10,393,746

KIT FOR IMMUNOLOGICAL DETECTION OF TNF-ALPHA, STNFR1 AND IL-8 IN PROSTATE CANCER

Health Research, Inc., B...

1. A kit for use in immunological detection of tumor necrosis factor ?(TNF?), soluble TNF receptor 1 (sTNFR1), interleukin-8 (IL-8), and Prostate Serum Antigen (PSA), wherein the kit comprises one or more sealed containers that comprise monoclonal and/or polyclonal capture antibodies that are specific for TNF?, sTNFR1, IL-8, and PSA, and wherein the kit comprises one or more sealed containers that comprise monoclonal and/or polyclonal detection antibodies that are for use in specifically binding to captured TNF?, sTNFR1, IL-8, and PSA.
US Pat. No. 10,393,747

DIAGNOSTIC METHOD FOR GASTRIC CANCER

Korea Advanced Institute ...

1. A method comprising:separating haptoglobin from a sample derived from a subject;
separating N-glycan by treating the haptoglobin with an enzyme;
performing mass spectrometry on the separated N-glycan; and
performing quantitative profiling for a result of the mass spectrometry by one or more selected from the group consisting of a receiver-operation characteristic (ROC) curve analysis, and an area-under-the-ROC curve (AUC) analysis on one or more selected from the group consisting of tri-antennary Hex6-HexNAc5-Fuc1 glycan (2151.8 m/z) and tetra-antennary Hex7-HexNAc6-Fuc1 glycan (2516.9 m/z);
identifying that the subject has gastric cancer or a high risk of gastric cancer
when an AUC value of tri-antennary Hex6-HexNAc5-Fuc1 glycan (2151.8 m/z) is 0.9 or higher,
when an AUC value of tetra-antennary Hex7-HexNAc6-Fuc1 glycan (2516.9 m/z) is 0.9 or higher,
when an average of the AUC value of tri-antennary Hex6-HexNAc5-Fuc1 glycan (2151.8 m/z) and the AUC value of tetra-antennary Hex7-HexNAc6-Fuc1 glycan (2516.9 m/z) is 0.9 or higher, or
when a sum of the AUC value of tri-antennary Hex6-HexNAc5-Fuc1 glycan (2151.8 m/z) and the AUC value of tetra-antennary Hex7-HexNAc6-Fuc1 glycan (2516.9 m/z) is 0.9 or higher; and
administering a therapeutic drug to said identified subject for treating gastric cancer.
US Pat. No. 10,393,748

METHOD FOR PREDICTING EFFICACY OF C-MET INHIBITOR

SAMSUNG ELECTRONICS CO., ...

1. A method for selecting a subject suitable for the application of a c-Met inhibitor in cancer treatment, comprising:measuring the level of IL-8 in a serum sample from a patient having cancer;
determining the presence of K-RAS and B-RAF mutations in a cancer tissue sample from the patient having cancer;
measuring the level of c-Met expression in a cancer tissue sample from the patient having cancer;
selecting the patient as the subject suitable for the application of a c-Met inhibitor when the level of IL-8 in the serum sample is about 500 pg/ml or higher, no K-RAS or B-RAF mutations are found in the cancer tissue sample, and c-Met is expressed in the cancer tissue sample; and
administering the c-Met inhibitor to the selected patient.
US Pat. No. 10,392,469

EPOXY RESIN COMPOSITIONS FOR PRODUCTION OF STORAGE-STABLE COMPOSITES

Evonik Degussa GmbH, Ess...

11. A composite component, obtained from at least one fibrous carrier and at least one crosslinked epoxy resin composition, wherein said epoxy resin composition is as defined in claim 1.
US Pat. No. 10,392,472

BIODEGRADABLE CROSS-LINKED POLYMER AND METHODS OF PREPARING THE SAME

Shanghai Microport Medica...

1. A biodegradable cross-linked polymer for manufacturing a vascular stent, wherein the biodegradable cross-linked polymer is formed from a biodegradable polymeric material having two or more arms,wherein the biodegradable polymeric material having two or more arms is a random copolymer formed of a first monomer and a second monomer different from the first monomer, wherein the first monomer is selected from the group consisting of L-lactide, DL-lactide, glycolide, ?-caprolactone, trimethylene carbonate, p-dioxanone, and the second monomer is one or two selected from the group consisting of D-lactide, DL-lactide, glycolide, ?-caprolactone, trimethyl carbonate, salicylic acid, carbonates, amino acids and derivatives thereof, and wherein the biodegradable polymeric material having two or more arms has a number-average molecular weight of from 20,000 to 1,200,000, an intrinsic viscosity of from 0.1 to 9.0 dl/g and an elastic modulus of from 2.5 GPa to 4.5 Gpa at room temperature, and
wherein each of terminal groups on the arms of the biodegradable polymeric material having two or more arms is selected from the group consisting of hydroxyl, amino and carboxyl groups.
US Pat. No. 10,393,752

MASS SPECTROMETRY-CLEAVABLE CROSS-LINKING AGENTS

THE REGENTS OF THE UNIVER...

1. An MS-cleavable cross-linker for mapping intra-protein interactions in a protein, inter-protein interactions in a protein complex or a combination thereof, the MS-cleavable cross-linker comprising:two amine-reactive N-hydroxysuccinimdyl (NHS) ester groups;
a spacer arm with at least one central sulfoxide group, wherein the at least one central sulfoxide group is linked to each of the two amine-reactive N-hydroxysuccinimdyl (NHS) ester groups through at least two methylene groups; and
two symmetric collision-induced dissociation (CID) cleavable bonds on the spacer arm,
wherein each of the two CID cleavable bond is a C—S bond adjacent to the at least one central sulfoxide.
US Pat. No. 10,393,753

HUMAN EXHALED AEROSOL DROPLET BIOMARKER SYSTEM AND METHOD

University of Maryland, C...

1. A method for detecting a biomarker in exhaled breath condensate nanodroplets, comprising the steps of:noninvasively collecting exhaled breath condensate (EBC) nanodroplets from a subject by impacting said nanodroplets into a liquid medium; and
analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction (IqPCR) to detect one or more target biomarkers in said nanodroplets.
US Pat. No. 10,392,475

POLYAMIDE ELASTOMER, MEDICAL DEVICE, AND METHOD FOR PRODUCING POLYAMIDE ELASTOMER

KANEKA CORPORATION, Osak...

1. A polyamide elastomer that is a reaction product of at least components (a), (b), and (c):the component (a) being at least one compound represented by formula (1):
HOOC—R1?NH—CO—R1?nNH2  (1)where each R1 independently represents a linear saturated hydrocarbon group containing 1 or more carbon atoms; n represents a real number of 0 or greater; and when the formula contains two or more types of repeating units each containing R1, n represents a total number of the two or more types of the repeating units each containing R1, the component (a) having a number average molecular weight of 4000 or higher and 10,000 or lower;the component (b) being at least one compound represented by formula (2):
HOOC—R2—COOH  (2)where R2 represents a direct bond or a linear saturated hydrocarbon group containing 1 or more carbon atoms;the component (c) being at least one compound represented by formula (3):
H2N—R4?O—R4?mNH2  (3)where each R4 independently represents a saturated hydrocarbon group containing 1 or more carbon atoms; m represents a real number of 1 or greater; and when the formula contains two or more types of repeating units each containing R4, m represents a total number of the two or more types of the repeating units each containing R4, the component (c) having a number average molecular weight of 500 or higher and 700 or lower.
US Pat. No. 10,393,755

COMPOSITIONS AND METHODS FOR TREATING EYE INFECTIONS AND DISEASE

University of Virginia Pa...

1. A sterile, aqueous pharmaceutical composition for topical administration to an ocular surface, the composition comprising:a peptide, or a pharmaceutically acceptable salt thereof,
wherein the peptide, or a pharmaceutically acceptable salt thereof, has an amino acid sequence consisting of SEQ ID NO: 5,
wherein the C-terminus of the peptide is amidated,
wherein the N-terminus of the peptide is acetylated, and a pharmaceutically acceptable aqueous carrier,
wherein the sterile, aqueous pharmaceutical composition is suitable for topical administration to an ocular surface of a subject, and
wherein the sterile, aqueous pharmaceutical composition is free of any type of enzymatic, chemical or biochemical molecule capable of breakdown of the peptide at its termini that is sequential degradation of the peptide at a terminal end thereof in the absence of the C-terminus amidation and the N-terminus acetylation.
US Pat. No. 10,391,195

SUPER-ABSORBING POLYMERS WITH RAPID ABSORPTION PROPERTIES AND METHOD FOR PRODUCING THE SAME

Evonik Degussa GmbH, Ess...

1. A method for preparing a low cellulose content absorbent core by selecting a particulate superabsorbent polymer material for incorporating the particulate absorbent polymer material in an absorbent core containing an upper substrate layer, a lower substrate layer and also an absorption layer arranged between the upper and the lower substrate layers, wherein the absorption layer comprises the particulate absorbent polymer material and less than 0.1 g of cellulose fibres per gram of particulate absorbent polymer material, containing the steps ofA) identifying a particulate absorbent polymer material having at least one of the following properties:
i) a maximum APCi×10 sec value ?1.6 for at least one number i selected from the group of integers from 2 to 12; and/or
ii) a value ?12 for the sum total of all APCi×10 sec sec values for all numbers i from the group of integers from 2 to 12;
wherein APCi×10 sec value is defined as follows:
APCi×10 sec value=(QIi×10 sec value)2×PIi×10 sec value, where
the QIi×10 sec sec value is the value of the swell index determined i×10 seconds after adding a 0.9% by weight NaCl solution, and
the PIi×10 sec value is the value of the permeability index determined i×10 seconds after adding the 0.9% by weight NaCl solution; and
B) incorporating the particulate absorbent material in an absorbent core.
US Pat. No. 10,392,478

METHOD FOR PRODUCING WET RUBBER MASTERBATCH

TOYO TIRE CORPORATION, I...

1. A method for producing a wet rubber masterbatch containing at least a filler, a dispersing solvent and a rubber latex solution as raw materials, the method comprising :a step (I) of dispersing the filler into the dispersing solvent , and adding, at the time of the dispersing, at least one portion of the rubber latex solution to the dispersing solvent to produce a slurry solution containing the filler to which particles of the rubber latex adhere;
a step (II) of mixing the slurry solution containing the filler, to which the rubber latex particles adhere, with the rest of the rubber latex solution to produce a rubber latex solution containing the filler, to which the rubber latex particles adhere; and
a step (III) of solidifying and drying the rubber latex solution containing the filler,
wherein the filler has a ratio of the nitrogen adsorption specific surface area (N2SA) thereof to the iodine adsorption amount (IA) thereof ((N2SA)/(IA)) of 1.00 or more, and
wherein the nitrogen adsorption specific surface area (N2SA) of the filler is 100 m2/g or more.
US Pat. No. 10,391,196

PREFABRICATED ALGINATE-DRUG BANDAGES

President and Fellows of ...

1. A method of making a bandage composition, comprising:(1) providing an alginate solution comprising a therapeutic agent;
(2) adding a woven mesh to said alginate solution;
(3) molding said alginate solution comprising the woven mesh into a desired shape;
(4) inducing a cryo-organized structure by freezing and lyophilizing said molded solution; and
(5) contacting said cryo-organized structure with a crosslinking agent to yield a bandage composition, wherein said bandage composition comprises a Young's modulus of 100 kiloPascals to 10,000 kiloPascals at room temperature.
US Pat. No. 10,392,479

PLATINUM COMPLEXES AND THEIR USE IN COMPOUNDS THAT CAN BE CROSS-LINKED BY A HYDROSILYLATION REACTION

WACKER CHEMIE AG, Munich...

1. A platinum complex of the formulaR33Pt{CpR45-r-t[(CR2)nSiR1oR2p]t[SiR7sR83-s]r}  (I)
where
Cp is a cyclopentadienyl radical,
n is an integer from 1 to 8,
o is 0, 1, 2 or 3,
p is 0, 1, 2 or 3, with the proviso that o+p=3,
r is 1, 2, 3, 4 or 5,
t is 0, 1, 2, 3 or 4, with the proviso that r+t?5,
s is 0, 1 or 2,
R each is the same or different and is hydrogen or a monovalent unsubstituted or substituted hydrocarbyl radical,
R1 each is the same or different and is a monovalent unsubstituted or substituted hydrocarbyl radical which is optionally interrupted by heteroatoms,
R2 each is the same or different and is a hydrolyzable group or an oxygen-bonded siloxy radical,
R7 each is the same or different and is a monovalent, unsubstituted or substituted, aliphatically saturated hydrocarbyl radical which may be interrupted by heteroatoms, or an oxygen-bonded siloxy radical,
R8 each is the same or different and is an aliphatically unsaturated, optionally substituted radical,
R3 each is the same or different and is a monovalent, unsubstituted or substituted, aliphatically saturated hydrocarbyl radical,
R4 each is the same or different and is a hydrogen atom, SiC-bonded silyl radical or an unsubstituted or substituted hydrocarbyl radical which may be interrupted by heteroatoms.
US Pat. No. 10,395,807

GRAIN-ORIENTED ELECTRICAL STEEL SHEET HAVING EXCELLENT MAGNETIC CHARACTERISTICS AND COATING ADHESION

JFE STEEL CORPORATION, T...

1. A grain-oriented electrical steel sheet provided on its sheet surface with a tension-imparting type insulation coating constituted with a coating layer A formed on a steel sheet side and mainly composed of an oxide and a coating layer B formed on the coating layer A and mainly composed of glass, characterized in that a ratio R (?B/?A) of a tension ?B to a tension ?A is within a range of 1.20-4.0, wherein:the tension ?A is a tensile stress applied to the steel sheet by the coating layer A as a result of a difference between the coefficient of thermal expansion of the steel sheet and the coefficient of thermal expansion of the coating layer A, and
the tension ?B is a tensile stress applied to the steel sheet by the coating layer B as a result of a difference between the coefficient of thermal expansion of the steel sheet and the coefficient of thermal expansion of the coating layer B.
US Pat. No. 10,392,480

CATALYST CONTAINING AMIDINE GROUPS

SIKA TECHNOLOGY AG, Baar...

1. A method of catalyzing hydrolysis or condensation or both of a polymer containing silane groups, comprising contacting a catalyst with the polymer containing silane groups, wherein:the catalyst comprises at least one amidine of the formula (I)
Y-A-Z  (I)
where
A is a divalent hydrocarbyl radical which has 2 to 30 carbon atoms and optionally contains unsaturated components and optionally ether oxygen or secondary or tertiary amine nitrogen,
Y is NR8R9 where R8 and R9 are independently an alkyl radical having 1 to 8 carbon atoms, or together are an optionally substituted alkylene radical having 4 to 10 carbon atoms, and
Z is an amidine group bonded via a nitrogen atom,
where Y and Z are separated from one another by at least two carbon atoms, and/or
at least one reaction product of at least one amidine of the formula (I) with at least one functional compound,
wherein A is not a polyoxyalkylene radical and wherein the amidine of the formula (I) does not contain any nitrogen atom which is directly bonded to an aromatic ring or is part of a heteroaromatic ring system.
US Pat. No. 10,393,760

SPECIALIZED EXCITATORY SYNAPTIC PROTEIN BIOMARKERS OF PLASMA NEURONAL EXOSOMES FOR PREDICTION AND STAGING OF ALZHEIMER'S DISEASE

1. Method of diagnosing and treatment of Alzheimer's Disease (AD) comprising(a) obtaining a venous blood sample from a human patient;
(b) extracting from the venous blood sample synaptic proteins of neuronal pentraxin 2 (NPTX2), GluA4-containing glutamate receptor (AMPA4), neurexin 2? (NRXN2?), and neuroligin 1 (NLGN1),
(c) determining neuron-derived exosome (NDE) levels for each synaptic pair of (i) NPTX2 and AMPA4 of (b) and (ii) NRXN2? and NLGN1 of (b),
(d) comparing said NDE levels of each said synaptic pair of (c) with NDE levels of synaptic pairs of (i) NPTX2 and AMPA 4 and (ii) NRXN2? and NLGN1 obtained from the same human patient at a clinically meaningful earlier point in time or obtained, from a control subject known to not have cognitive losses, and detecting a decrease in NDE levels between the compared synaptic pairs; and
(e) administering to the human patient treatment for AD.
US Pat. No. 10,392,482

FIBER-REINFORCED RESIN MOLDING MATERIAL AND PRODUCTION METHOD THEREOF

Toray Industries, Inc., ...

1. A fiber-reinforced resin molding material comprising at least bundled aggregates of discontinuous reinforcing fibers and matrix resin, wherein said bundled aggregates of reinforcing fibers comprise both reinforcing fiber aggregates (A) which are formed by cutting continuous reinforcing fiber strands after fiber splitting, in which said strands are completely split into multiple bundles, and reinforcing fiber aggregates (B) having at least unsplit strand sections in which fiber splitting is incomplete, an incision originating from fiber splitting is present at least at one of both end portions of said reinforcing fiber aggregates (B), and a ratio of the weight of said reinforcing fiber aggregates (B) to the total weight of reinforcing fibers in said material is 5-50%.
US Pat. No. 10,392,742

BIOFINISHING SYSTEM

1. A process for biofinishing a cellulose-containing textile, comprising:(a) treating the cellulose-containing textile with a first GH45 cellulase having biofinishing activity; and
(b) treating the cellulose-containing textile with a second GH45 cellulase having biofinishing activity,
wherein the first GH45 cellulase or the second GH45 cellulase has at least 90% sequence identity to SEQ ID NO: 2, at least 90% sequence identity to amino acids 22-299 of SEQ ID NO: 4, at least 90% sequence identity to amino acids 22 to 294 of SEQ ID NO: 6 or at least 90% sequence identity to amino acids 22-293 of SEQ ID NO: 8.
US Pat. No. 10,392,488

METHOD FOR PRODUCING EXPANDED THERMOPLASTIC ELASTOMER PARTICLES

BASF SE, (DE)

1. A process for production of expanded thermoplastic elastomer beads having an uninterrupted skin, said process comprising;a) impregnating a blowing agent into thermoplastic elastomer beads to give impregnated thermoplastic elastomer beads, the thermoplastic elastomer beads being surrounded by a gaseous medium that has an impregnating temperature Ta, wherein the absolute pressure of the gaseous medium is greater than ambient pressure, and wherein the thermoplastic elastomer beads are selected from thermoplastic polyester elastomers, thermoplastic copolyamides or thermoplastic polyurethanes, or mixtures thereof,
b) expanding the impregnated thermoplastic elastomer beads by exposing the thermoplastic elastomer beads to a pressure reduction at a first expanding temperature Tb to give expanded thermoplastic elastomer beads and
c) optionally a fusing step, wherein the expanded thermoplastic elastomer beads are fused together at a fusing temperature Tc to form at least one shaped part,
wherein the thermoplastic elastomer beads are made from amorphous thermoplastic elastomer, partly crystalline thermoplastic elastomer, or mixtures thereof, and the impregnating temperature Ta, the first expanding temperature Tb and the fusing temperature Tc each depend on the thermoplastic elastomer wherein,
i. if the thermoplastic elastomer is amorphous, the impregnating temperature Ta, the first expanding temperature Tb and the fusing temperature Tc are higher than a first limiting temperature TG-40, wherein the first limiting temperature TG-40 is 40° C. below the glass transition temperature TG according to DIN EN ISO 11357-2:2013-09 of the thermoplastic elastomer beads not being impregnated, or
ii. if the thermoplastic elastomer is partly crystalline, the impregnating temperature Ta, the first expanding temperature Tb and the fusing temperature Tc are higher than the glass transition temperature TG according to DIN EN ISO 11357-2:2013-09 of the nonimpregnated thermoplastic elastomer beads and lower than a second limiting temperature TS-5 which is 5° C. below the melting temperature TS according to DIN EN ISO 11357-3:2013-04 of the thermoplastic elastomer beads not being impregnated.
US Pat. No. 10,392,492

POLYPROPYLENE COMPOSITION SUITABLE FOR PRIMERLESS PAINTING

BOREALIS AG, Vienna (AT)...

1. Polypropylene composition (C), the polypropylene composition (C) comprising:(a) 40.0 to 80.0 wt. %, based on the total weight of the composition, of a propylene copolymer (R-PP) wherein the propylene copolymer (R-PP) comprises two fractions, a first propylene copolymer fraction (R-PP1) and a second propylene copolymer fraction (R-PP2), said first propylene copolymer fraction (R-PP1) differs from said second propylene copolymer fraction (R-PP2) in the comonomer content; wherein the propylene copolymer (R-PP) having
(a1) a comonomer content in the range of 1.5 to 8.0 wt. %, and
(a2) a melt flow rate MFR2 (230° C.) measured according to ISO 1133 in the range of 5.0 to 100.0 g/10 min, and
wherein the propylene copolymer (R-PP) has:
(a3) a glass transition temperature in the range of ?12 to +2° C.; and/or
(a4) no glass transition temperature below ?20° C.; and
(b) 20.0 to 40.0 wt. %, based on the total weight of the composition, of a mineral filler (F) being selected from the group consisting of talcum, wollastonite, kaolin, and mica,
wherein the polypropylene composition (C) has a melt flow rate MFR2 (230° C.) measured according to ISO 1133 in the range of 5.0 to 45.0 g/10 min.
US Pat. No. 10,392,493

DISPERSION SOLUTION, ORGANIC/INORGANIC HYBRID MATERIAL AND PREPARATION METHOD THEREOF

Industrial Technology Res...

1. A dispersion solution, comprising:a first solvent;
a second solvent miscible with the first solvent, wherein boiling points of the first solvent and the second solvent are different;
an inorganic nano sheet material dispersed in the first solvent, wherein the inorganic nano sheet material is an un-modified inorganic sheet material; and
a polymer dissolved in the second solvent, wherein the polymer is polyimide (PI),
wherein the inorganic nano sheet material is not dispersed in the second solvent, and the dispersion solution is a suspended emulsion and has an absorbance peak in a wavelength range of from 350 nm to 650 nm.
US Pat. No. 10,392,750

METHOD AND DEVICE FOR MONITORING A WEAR STRUCTURE, IN PARTICULAR A SEALING STRUCTURE

Voith Patent GmbH, Heide...

1. A sealing assembly, comprising:a device for monitoring a sealing structure including at least one sealing element for sealing at least one negative or positive pressure zone adjoining a surface moving in a direction of movement in a machine for producing or processing a fibrous web;
at least one wear sensor associated with said at least one sealing element;
a signal transmission device for transmitting a signal from said at least one wear sensor; and
a computer system receiving the signal from said signal transmission device, said computer system being configured to carry out the following steps:
providing a time z0 at which the sealing element became operational;
providing a time z1 at which a defined first level of wear of the sealing element was reached;
providing at least one further characteristic variable describing a machine speed, operating times of the machine, stoppage times of the machine, at least one of type or quantity of products being produced, or a contact pressure of the sealing element onto the moving surface; and
predicting a remaining operating time of the sealing element from the times z0 and z1 and the at least one further characteristic variable.
US Pat. No. 10,391,725

SUCKER ROD

1. A method of making a sucker rod component comprising the steps of:providing a sucker rod material;
wherein said chosen sucker rod material is chosen from a list of sucker rod materials consisting of fiberglass and carbon fiber;
providing graphene platelets;
providing an epoxy material;
forming a plurality of strands from said sucker rod material;
coating said plurality of strands with a portion of said graphene platelets;
mixing a portion of said epoxy material with a portion of said graphene platelets;
bonding said plurality of strands together using said mix of said epoxy material and said graphene platelets; and
forming said sucker rod component from said bonded plurality of strands.
US Pat. No. 10,392,495

POLYVINYL ACETAL COMPOSITION

KURARAY CO., LTD., Kuras...

1. A composition, comprising:100 parts by mass of a polyvinyl acetal; and
30 to 70 parts by mass of a plasticizer comprising 0.5 to 100% by mass of a first plasticizer and 0 to 99.5% by mass of a second plasticizer, a total of the first plasticizer and the second plasticizer being 100% by mass,
wherein the first plasticizer comprises a hydroxyl group and is an ester compound,
wherein the second plasticizer is a compound that does not comprise a polar group selected from the group consisting of a hydroxyl group, a polyethylene oxide group having a polymerization degree of 10 or more, a polypropylene oxide group having a polymerization degree of 10 or more, a carboxyl group, and an amino group, and
wherein when the polyvinyl acetal is analyzed by high performance liquid chromatography using a column having an inner diameter of 4 mm and a length of 1 cm, the polyvinyl acetal exhibits a first peak and a second peak derived from polyvinyl acetals, the column being filled with spherical silica gel surface-modified with an octadecylsilyl group, serving as a stationary phase,
wherein the polyvinyl acetal is a mixture of polyvinyl acetal (A) and polyvinyl acetal (B) having different average amounts of remaining hydroxyl groups.
US Pat. No. 10,392,752

PAPER COMPOSITION AND PROCESS FOR MAKING THE SAME

DOW GLOBAL TECHNOLOGIES L...

1. A paper composition comprising, based on the total weight of the paper composition,a) from 15 wt. % to 70 wt. % a hiding composite,
wherein the hiding composite comprises based on the total weight of the hiding composite, from 30 wt. % to 75 wt. % pigment particles and from 25 wt. % to 70 wt. % a thermoplastic polymer,
wherein the pigment particles are hydrophobically treated by silanization, the surface tension of the pigment particles is from 0.1 to 50 mN/m, and the surface tension difference between the pigment particles and the thermoplastic polymer is less than 40 mN/m; and
b) from 30 wt. % to 85 wt. % a paper pulp.
US Pat. No. 10,392,497

RUBBER COMPOSITIONS INCLUDING SILICEOUS FILLERS

Bridgestone Corporation, ...

1. A process for making a filled rubber composition, said process comprising (a) providing filler particles that comprise oxides of silicon and bound residues of one or more compounds having the general formula YR1L where L is a group that contains at least one Si—O bond, R1 is a hydrocarbylene group, and Y is a functionality that comprises a —OH, —SH, —NHR2, —CN, —C(O)R2 or —NCO group in which R2 is H or a substituted or unsubstituted hydrocarbyl group, and (b) blending(1) a polymer that comprises
(i) ethylenic unsaturation and
(ii) pendent or terminal functionality which comprises an aryl group having at least two substituents defined by the formula —OR, wherein R is H or a hydrolyzable group, or an oxidation product thereof; with
(2) said filler particles.

US Pat. No. 10,397,535

OPTICAL MICRO-PROJECTION SYSTEM AND PROJECTION METHOD

North Inc., Kitchener, O...

1. A system comprising:a photodiode to receive a reflection of a light beam emitted by a light source onto a projection field;
a processor coupled to the photodiode and the light source; and
a memory coupled to the processor, the memory comprising instructions that when executed by the processor cause the processor to:
receive, from the photodiode, an indication of the reflection of the emitted light beam;
detect, based on the reflection, an object proximate to the projection field;
determine a distance between the light source and the object at a plurality of points on the object;
determine a volume of the object based at least in part on the determined distances; and
cause the light source to emit the light beam to project an image around the object.

US Pat. No. 10,396,743

FREQUENCY-DOMAIN DYNAMIC RANGE CONTROL OF SIGNALS

NXP B.V., Eindhoven (NL)...

1. A gain function controller comprising a processor and non-transitory computer readable medium, the processor configured to:receive a first plurality of sub-band-signals that is based on a first full-band signal;
determine a frequency-domain-gain-function for a second plurality of sub-band-signals that is based on a second full-band signal, wherein the second full-band signal is not based on the first full-band signal, and wherein determining the frequency-domain-gain-function for the second plurality of sub-band-signals comprises determining the frequency-domain-gain-function for the second plurality of sub-band-signals based on:
the first plurality of sub-band-signals;
a power of the first full-band signal that does not include a power of the second full-band signal, wherein the first full-band signal is a measured noise signal or an estimated noise signal; and
a predetermined compression curve;
apply the frequency-domain-gain-function to the second plurality of sub-band-signals to provide a frequency-domain-output-signal, wherein the processor is further configured to determine the frequency-domain-gain-function to jointly control the second plurality of sub-band-signals based on an adaptive spectral subtraction factor that is identical for all sub-bands such that the frequency-domain-output-signal, when coupled to a loudspeaker, drives the loudspeaker within a pre-determined displacement limit for mechanical loudspeaker protection.

US Pat. No. 10,396,360

POLYMERIZATION PROCESS FOR FORMING POLYMERIC ULTRATHIN CONFORMAL COATINGS ON ELECTRODE MATERIALS

GM GLOBAL TECHNOLOGY OPER...

1. A negative electrode material for a lithium-ion electrochemical cell comprising:a flexible polymeric ultrathin conformal coating formed on a surface of the negative electrode material selected from the group consisting of: silicon, silicon-containing alloys, tin-containing alloys, and combinations thereof, wherein the flexible polymeric ultrathin conformal coating comprises one or more materials selected from silicon, siloxane, polycaprolactam, polyethylene oxide, and TEMPO methacrylate and the flexible polymeric ultrathin conformal coating has a thickness of less than or equal to about 50 nm and is capable of reversibly elongating by at least 50% from a contracted state to an expanded state in at least one direction to minimize or prevent fracturing of the negative electrode material during lithium ion cycling.