US Pat. No. 10,479,820

ENHANCED PRODUCTION OF RECOMBINANT CRM197 IN E. COLI

SCARAB GENOMICS, LLC, Ma...

1. A method for producing a recombinant CRM197 in a reduced genome E. coli host, the method comprising incubating a reduced genome E. coli comprising an expression vector comprising a nucleotide sequence encoding a CRM197 protein fused to an ompA, ompF or ytfQ signal sequence that directs transfer of the CRM197 protein to the periplasm, said nucleotide sequence operably linked to an expression control sequence, under conditions suitable for the expression of the recombinant CRM197 protein, whereby a yield of at least 1 gram per liter of soluble CRM197 is obtained, wherein the native parent strain of the reduced genome E. coli host is an E. coli K-12 strain comprising a native ?2 frameshift mutation in the ilvG gene, and wherein the reduced genome E. coli host comprises the following modifications relative to the native parent E. coli strain: (i) deletion of at least the following DNA segments: b0245-b0301, b0303-b0310, b1336-b1411, b4426-b4427, b2441-b2450, b2622-b2654, b2657-b2660, b4462, b1994-b2008, b4435, b3322-b3338, b2349-b2363, b1539-b1579, b4269-b4320, b2968-b2972, b2975-b2977, b2979-b2987, b4466-4468, b1137-b1172, b0537-b0565, b0016-b0022, b4412-b4413, b0577-b0582, b4415, b2389-b2390, b2392-b2395, b0358-b0368, b0370-b0380, b2856-b2863, b3042-b3048, b0656, b1325-b1333, b2030-b2062, b2190-b2192, b3215-b3219, b3504-b3505, b1070-b1083, b1878-b1894, b1917-b1950, b4324-b4342, b4345-b4358, b4486, b0497-b0502, b0700-b0706, b1456-b1462, b3481-b3484, b3592-b3596, b0981-b0988, b1021-b1029, b2080-b2096, b4438, b3440-b3445, b4451, b3556-b3558, b4455, b1786, b0150-b0153 and b2945 of the E. coli K12 strain MG1655 or the corresponding DNA segments in another E. coli K12 strain (ii) deletion of the rph gene to enhance orotate phosphoribosyltransferase activity (iii) correction of the native ?2 frameshift mutation in the ilvG gene in order to restore the active acetohydroxy acid synthase II production and (iv) deletion of all or part of the iclR and arpA genes.
US Pat. No. 10,483,412

HIGH EFFICIENCY LOCAL BACK ELECTRODE ALUMINUM PASTE FOR CRYSTALLINE SILICON SOLAR CELLS AND ITS APPLICATION IN PERC CELLS

NANTONG T-SUN NEW ENERGY ...

1. A high efficiency back electrode local aluminum paste for crystalline silicon solar cells comprising the following components proportioned to weights:70-85 parts for aluminum powder,
1-30 parts for organic carrier,
0.1-10 parts for inorganic binder, and
0.1-1 parts for auxiliary conductive additive including graphene.
US Pat. No. 10,479,822

PHARMACEUTICAL COMPOSITIONS CONTAINING, AS ACTIVE INGREDIENT, GRANULOCYTE-COLONY STIMULATING FACTOR MUTANT PROTEIN OR TRANSFERRIN FUSION PROTEIN THEREOF

SUPEX BNP CO., LTD., Gye...

1. A fusion protein in which transferrin is peptide-bonded to a G-CSF (granulocyte-colony stimulating factor) mutant protein in which the 116th threonine is substituted with a cysteine.
US Pat. No. 10,479,823

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells that aberrantly express a peptide consisting of the amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 6, SEQ ID NO: 17, SEQ ID NO: 27, and SEQ ID NO: 77;wherein said cancer is selected from the group consisting of hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer, non-small cell lung cancer (NSCLC), pancreatic cancer (PC), renal cell carcinoma (RCC), benign prostate hyperplasia (BPH), prostate cancer (PCA), ovarian cancer (OC), melanoma, breast cancer (BRCA), chronic lymphocytic leukemia (CLL), small cell lung cancer (SCLC), Non-Hodgkin lymphoma (NHL), acute myeloid leukemia (AML), gallbladder cancer and cholangiocarcinoma (GBC, CCC), urinary bladder cancer (UBC), and uterine cancer (UEC).
US Pat. No. 10,478,800

HIGHLY ORDERED TITANIA NANOTUBE ARRAYS FOR PHOSPHOPROTEOMICS

UNIVERSITY OF HOUSTON SYS...

1. A device for isolation of phosphopeptides in a sample, comprising:an ordered TiO2 nanotube array comprising ordered TiO2 nanotubes grown on a Ti surface, wherein the nanotubes point outward from the Ti surface, wherein the Ti surface is a Ti wire, and wherein the nanotubes point radially outward from the Ti wire; and
a container for phosphopeptide isolation, wherein the ordered TiO2 nanotube array is located within the container, and wherein the sample is placed in the container to contact the ordered TiO2 nanotube array.
US Pat. No. 10,479,825

ANTIBODY-MEDIATED NEUTRALIZATION OF MARBURG VIRUS

VANDERBILT UNIVERSITY, N...

1. An engineered cell producing an antibody or antibody fragment characterized by heavy chain CDR sequences of SEQ ID NOS: 104, 105 and 106 and light chain CDR sequences of SEQ ID NO: 150, DNN and SEQ ID NO: 151.
US Pat. No. 10,478,801

PROCESS FOR OBTAINING ADSORBENT MATERIAL BASED ON POROUS SILICATES FOR REDUCTION OF SULFUR AND NITROGEN IN OIL FRACTIONS

INSTITUTO MEXICANO DEL PE...

1. A process for reducing a sulfur and nitrogen content of a petroleum fraction or product derived therefrom, comprising the steps of:contacting the petroleum fraction or product derived therefrom with a porous silicate adsorbent containing at least one metal selected from the group consisting of Cu, Ni, Sn, Fe, Ag, Co, Ti, V, Cr, and Mn; and
adsorbing and removing sulfur and/or nitrogen compounds from said petroleum fraction or product derived therefrom.
US Pat. No. 10,479,826

SINGLE CHAIN ANTIBODY DOMAINS FOR DETECTION OF ANTI-BOTULINUM NEUROTOXIN DOMAINS AND METHODS OF THEIR USE

CITY OF HOPE, Duarte, CA...

1. A single chain antibody binding domain (VHH) comprising (a) a first complementary determining region amino acid sequence (CDR1) comprising GSGISGIA (SEQ ID NO:5), (b) a second complementary determining region amino acid sequence (CDR2) comprising IFSGGST (SEQ ID NO:6) and (c) a third complementary determining region amino acid sequence (CDR3) comprising RLYGSGDYWVQ (SEQ ID NO:7), wherein the VHH binds to botulinum neurotoxin with a dissociation constant (Kd) of less than 40 pM.
US Pat. No. 10,479,058

PRESSURE-SENSITIVE ADHESIVE SHEET

NITTO DENKO CORPORATION, ...

1. A pressure-sensitive adhesive sheet comprising:a pressure-sensitive adhesive layer (A) constituting an adhesive face, and
a viscoelastic layer (B) supporting the pressure-sensitive adhesive layer (A);
wherein
the viscoelastic layer (B) comprises hollow particles or have bubbles,
the viscoelastic layer (B) further comprises, as its base polymer, an acrylic polymer (b) obtained by polymerizing a starting monomer mixture that comprises an acidic group-containing monomer,
the pressure-sensitive adhesive layer (A) comprises an acrylic polymer (a) as its base polymer,
a glass transition temperature of the acrylic polymer (a) is ?60° C. to ?25° C.,
an acidic group-containing monomer is copolymerized in the acrylic polymer (a) at a ratio of 5% by weight or lower,
the acrylic polymer (a) has a dispersity (Mw/Mn) of 3 to 10, and
wherein a weight ratio (ACb/ACa) of the acidic group-containing monomer in the acrylic polymer (b) to the acidic group-containing monomer in the acrylic polymer (a) is 2 or higher and 10 or lower wherein the adhesive face exhibits a 90° peel strength to polypropylene of 30 N/25 mm.
US Pat. No. 10,480,083

STEAM ELECTROLYSIS CELL

NIPPON SHOKUBAI CO., LTD....

1. A steam electrolysis cell,comprising an anode layer, a cathode layer, and a proton conducting oxide electrolyte layer between the anode layer and the cathode layer,
wherein the anode layer is formed by sintering at a temperature of 900° C. or lower and comprises a perovskite oxide having an ABO3 type structure,
the perovskite oxide comprises Ba and Co,
a part of the A site of the perovskite oxide is substituted by La, and
a molar ratio of Co in the B site of the perovskite oxide is 90% or more.
US Pat. No. 10,479,828

COMPOSITIONS COMPRISING AN ANTI-C5 ANTIBODY

Alexion Pharmaceuticals, ...

1. A pharmaceutical composition comprising 30 mg/mL of an anti-C5 antibody, sodium phosphate at a concentration of 10 mM, sodium chloride at a concentration of 150 mM, and polysorbate 80 at a level of 0.001 to 0.02% by volume, wherein the anti-C5 antibody comprises a variable light chain CDR1 comprising amino acid residues 26-36 of SEQ ID NO:1, a variable light chain CDR2 comprising amino acid residues 52-58 of SEQ ID NO:1, a variable light chain CDR3 comprising amino acid residues 91-99 of SEQ ID NO:1, a variable heavy chain CDR1 comprising amino acid residues 152-161 of SEQ ID NO:1, a variable heavy chain CDR2 comprising amino acid residues 176-192 of SEQ ID NO:1, and a variable heavy chain CDR3 comprising amino acid residues 225-237 of SEQ ID NO:1, and wherein the pH of the composition is between pH 6 and pH 8.
US Pat. No. 10,479,060

CONCEALABLE FILM, LAMINATE, AND PACKAGING MATERIAL

Unitika Ltd., Hyogo (JP)...

11. A concealable film wherein on at least one surface of a layer A comprising 1 to 40% by mass of an amorphous polyamide resin, 10 to 60% by mass of titanium oxide and 0 to 89% by mass of a crystalline polyamide resin, with a proviso that the total content of these is 100% by mass, the crystalline polyamide resin being one selected from a group consisting of nylon 6 and polymetaxylylene adipamide, the amorphous polyamide resin including terephthalic acid and isophthalic acid as a dicarboxylic acid component and hexamethylenediamine and 4,4?-diamino-3,3?-dimethyl-dicyclohexylene methane as a diamine component, a layer B constituted with a polyamide resin and not including titanium oxide is laminated, the polyamide resin constituting the layer B including 80% or more by mass of nylon 6, the concealable film being stretched and having a thickness of 10 to 30 ?m and the concealable film having a multilayer structure that is one of B/A/B and B/A/B/A/B wherein each layer A directly contacts each layer B.
US Pat. No. 10,480,085

ION EXCHANGE MEMBRANES, ELECTROCHEMICAL SYSTEMS, AND METHODS

Calera Corporation, Moss...

1. An ion exchange membrane (IEM), comprising: an ionomer membrane with a built-in separator wherein one or more sections of the built-in separator protrude out from front and back surfaces of the ionomer membrane, wherein the built-in separator is a mesh and wherein the built-in separator is made of polyethylene.
US Pat. No. 10,479,830

ANTI EOTAXIN-2 ANTIBODIES THAT RECOGNIZE ADDITIONAL CCR3-BINDING CHEMOKINES

CHEMOMAB LTD., Tel Aviv ...

1. An isolated antibody that binds a conformational epitope in the N-loop region of a CCR3-binding chemokine, wherein said conformational epitope is characterized by a relatively high concentration of positive amino acid residues located between amino acid positions 14 and 24 in the amino acid sequence of said CCR3-binding chemokine as denoted by SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13 or SEQ ID NO: 14 and wherein said antibody is a fully humanized antibody comprising a heavy chain variable region comprising:a) the complementary determining region VH CDR1 comprising the amino acid sequence denoted by SEQ ID NO. 5;
b) the complementary determining region VH CDR2 comprising the amino acid sequence denoted by SEQ ID NO. 6; and
c) the complementary determining region VH CDR3 comprising the amino acid sequence denoted by SEQ ID NO. 7; and
a light chain variable region comprising
d) the complementary determining region VK CDR1 comprising the amino acid sequence denoted by SEQ ID NO. 8;
e) the complementary determining region VK CDR2 comprising the amino acid sequence denoted by SEQ ID NO. 9; and
f) the complementary determining region VK CDR3 comprising the amino acid sequence denoted by SEQ ID NO. 10.
US Pat. No. 10,479,831

BCR-COMPLEX-SPECIFIC ANTIBODIES AND METHODS OF USING SAME

MacroGenics, Inc, Rockvi...

1. A method of treating an autoimmune or immune-mediated inflammatory disease in a subject, comprising administering to said subject a therapeutically effective amount of a diabody that binds human BCR complex, wherein said diabody comprises:(I) an amino acid sequence of an immunoglobulin light chain variable region (VL) that is a humanized variant of BCC VL that comprises:
(A) a modification at Kabat residue 37;
(B) a modification at Kabat residue 45; or
(C) both (A) and (B); and
(II) an amino acid sequence of an immunoglobulin heavy chain variable region (VH) that is a humanized variant of BCC VH that comprises a modification of one or more of Kabat residues 48, 62, 66, 67, 68, 69, 70, 71 or 73.
US Pat. No. 10,479,832

METHOD OF TREATING BONE DISEASE

Universiteit Gent, Ghent...

1. A pharmaceutical composition comprising:an antibody that specifically binds sialoadhesin (Sn);
an agent for treating bone disorders in an amount useful for the treatment of a bone loss disorder or bone loss disorders in the subject; and
a pharmaceutically acceptable carrier and/or excipient.
US Pat. No. 10,478,809

CATALYST SYSTEM AND PROCESS FOR THE PRODUCTION OF GLYCOLS

SHELL OIL COMPANY, Houst...

1. A catalyst system comprising:a) one or more sodium phosphotungstate-containing species; and
b) one or more catalytic species suitable for hydrogenation.
US Pat. No. 10,479,836

METHOD FOR TREATING PULMONARY HYPERTENSION WITH INTERLEUKIN-5 RECEPTOR ANTIBODY

National University Corpo...

1. A method for treating pulmonary hypertension, comprising administering an effective amount of an antibody or an antibody fragment thereof which binds to the extracellular region of an interleukin-5 receptor (IL-5R) to inhibit an IL-5R-expressing cell,wherein said antibody or antibody fragment thereof comprises a heavy chain variable (VH) domain containing 3 complementarity determining regions (CDRs), and a light chain variable (VL) domain containing 3 CDRs,
wherein the 3 CDRs on said VH domain comprise the amino acid sequences of SEQ ID NOs: 1-3, respectively, and the 3 CDRs on said VL domain comprise the amino acid sequences of SEQ ID NOs: 4-6, respectively.
US Pat. No. 10,483,428

MULTICRYSTALLINE SILICON INGOTS, SILICON MASTERALLOY, METHOD FOR INCREASING THE YIELD OF MULTICRYSTALLINE SILICON INGOTS FOR SOLAR CELLS

REC SOLAR NORWAY AS, Kri...

1. A directionally solidified multicrystalline silicon ingot obtained by adding elemental calcium to a high purity silicon melt in an amount chosen from at least one of the following ranges: 5-9.99 ppmw, 10-500 ppmw, 500-550 ppmw, prior to directional solidification,wherein the ingot comprises reduced red zone along an outer part of an uncut ingot at a lower end, an upper end and/or sides of the ingot, compared to a directionally solidified ingot obtained without adding elemental calcium prior to directional solidification.
US Pat. No. 10,478,812

METHODS TO STORE TRANSITION METAL ORGANOPHOSPHOROUS LIGAND BASED CATALYSTS

Dow Technology Investment...

1. A method of preparing a hydroformylation catalyst solution for storage, the catalyst solution comprising:A. a transition metal in combination with one or more bisphosphite ligands,
B. a concentration of acidic species, and
C. water,the method comprising the steps of (i) mixing the catalyst solution with an aqueous buffer solution comprising one or more materials that will neutralize and/or absorb at least 50 percent of the acidic species and (ii) storing the mixed catalyst solution and aqueous buffer solution under a blanket of syngas.
US Pat. No. 10,477,787

METHOD TO IDENTIFY ASIAN SOYBEAN RUST RESISTANCE QUANTITATIVE TRAIT LOCI IN SOYBEAN AND COMPOSITIONS THEREOF

Monsanto Technology LLC, ...

1. A method for producing an Asian Soybean Rust (ASR) resistant soybean plant, said method comprising:selecting a soybean plant using marker assisted selection from a plurality of soybean plants derived from an ASR resistant soybean plant comprising ASR resistance locus 16 by detecting a molecular marker that is within 10 centimorgans or less from a resistance allele of a SNP marker selected from the group consisting of NS0113966 and NS0118536;
obtaining a seed from said selected plant, and
generating from said obtained seed an ASR-resistant progeny plant comprising said resistance allele.
US Pat. No. 10,477,789

METHODS AND COMPOSITIONS FOR PPO INHIBITOR TOLERANCE IN SOYBEANS

PIONEER HI-BRED INTERNATI...

1. A method of selecting a soybean plant or germplasm with tolerance or improved tolerance to herbicides that inhibit protoporphyrinogen oxidase function, the method comprising:a) screening a population of soybean plants or germplasm with one or more nucleic acids capable of detecting in a soybean plant or germplasm at least one allele of a marker locus that is associated with tolerance or improved tolerance to herbicides that inhibit protoporphyrinogen oxidase function, wherein the marker locus is localized within a chromosome interval defined by and including markers SATT495 and SATT613 on linkage group L;
b) selecting a soybean plant or germplasm that comprises the at least one allele of the marker locus thereby selecting a soybean plant with tolerance or improved tolerance to herbicides that inhibit protoporphyrinogen oxidase function; and
c) assaying the soybean plant or germplasm or an F1 progeny thereof with one or more herbicides that inhibit protoporphyrinogen oxidase function to determine if the plant, germplasm or progeny exhibits tolerance to herbicides that inhibit protoporphyrinogen oxidase function.
US Pat. No. 10,479,843

METHOD FOR PRODUCING NATURAL RUBBER

SUMITOMO RUBBER INDUSTRIE...

1. A method for producing natural rubber, comprisinga sheeting step which includes sheeting a cup lump to form a natural rubber sheet,
wherein the natural rubber sheet has a thickness of 3 cm or less and a moisture content of 20% or less.
US Pat. No. 10,477,791

METHOD OF PRODUCTION OF PHYTOCANNABINOIDS FOR USE IN MEDICAL TREATMENTS

CELL SCIENCE HOLDING LTD....

1. A method of producing one or more cannabinoids from Cannabis plant cells, the method comprising the steps of:selecting a Cannabis tissue for culture;
growing a cell suspension culture from the selected Cannabis tissue in a liquid based medium whilst controlling the light exposure of the cell suspension culture to control the content of the one or more cannabinoids produced by the cell suspension culture, the light exposure comprising UV light; and
extracting the one or more cannabinoids from the cell suspension culture.
US Pat. No. 10,477,792

TOMATO HYBRID SV0599TM

Seminis Vegetable Seeds, ...

1. A tomato plant of tomato hybrid SV0599TM, a sample of seed of said hybrid SV0599TM having been deposited under ATCC Accession Number PTA-121395.
US Pat. No. 10,478,563

FLUOROPOLYMER BARRIER MATERIALS FOR CONTAINERS

1. A syringe stopper for an unlubricated syringe, said syringe stopper comprising:an elastomeric body comprising an elastomer; and
an expanded fluoropolymer positioned on said elastomeric body,
wherein said elastomer is at least partially imbibed into said expanded fluoropolymer.
US Pat. No. 10,477,793

TOMATO LINE FIRKL13-4132

Seminis Vegetable Seeds, ...

1. A tomato plant comprising at least a first set of the chromosomes of tomato line FIRKL13-4132, a sample of seed of said line having been deposited under ATCC Accession Number PTA-122113.
US Pat. No. 10,479,847

POLYMER-ENCAPSULATED PIGMENT PARTICLE

SWIMC LLC, Cleveland, OH...

1. A pigment grind dispersion comprising a mixture of:a) a carrier comprising water;
b) opacifying inorganic pigment particles having an index of refraction of at least 1.8 and being at least partially encapsulated by at least one polymer layer;
c) alkali; and
d) a polymeric dispersing agent having one or more alkali-swollen or alkali-dissolved copolymer components, wherein the alkali-swollen or alkali-dissolved component is derived from ingredients including one or more ethylenically unsaturated hydrophilic monomers that include a hydroxyl group, acidic group, amino group or ethylene oxide group, and the polymeric dispersing agent is present at about 0.1 to about 25 wt. % of the opacifying pigment particle weight.
US Pat. No. 10,477,795

COTTON VARIETY PX499096W3FE

Phytogen Seed Company, LL...

1. A seed of cotton variety designated PX499096W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123655 on Nov. 15, 2016.
US Pat. No. 10,477,797

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH999869

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH999869, produced by crossing a first plant of variety CV181138 with a second plant of variety CV692417, wherein representative seeds of said varieties CV181138 and CV692417 are deposited under ATCC Accession Nos. PTA-123825 and PTA-125242, respectively.
US Pat. No. 10,477,798

LETTUCE VARIETY 81-04 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A seed of lettuce variety 81-04 RZ, a sample of seed of said variety having been deposited under NCIMB Accession No. 42634.