US Pat. No. 10,710,954

CONVERSION OF WOOD BASED HEMICELLULOSE PREHYDROLYSATE SUCCINIC ACID USING A HETEROGENEOUS ACID CATALAYST IN A BIPHASIC SYSTEM

1. A method of synthesizing succinic acid comprising:mixing a source of aqueous xylose with an organic solvent having low water solubility at a ratio of 1:1 to 1:5, wherein the organic solvent is selected from the group consisting of toluene, chloroform and ethyl acetate;
adding a suitable acid, thereby converting the xylose to furfural;
recovering an organic solvent phase comprising the furfural; and
adding hydrogen peroxide to the organic solvent phase comprising the furfural at a ratio of hydrogen peroxide to furfural of 1:1 to 1:5 in the presence of a macroreticular ion exchange catalyst having high acidic strength, said furfural transferring from the organic solvent phase to an aqueous phase comprising hydrogen peroxide and converting to succinic acid in the aqueous phase.

US Pat. No. 10,710,889

EMM-31 MATERIALS AND PROCESSES AND USES THEREOF

27. A structure directing agent compound having the following structure of Compound E:wherein A is an ion.
US Pat. No. 10,709,738

PEPTIDES AND COMBINATION OF PEPTIDES OF NON-CANONICAL ORIGIN FOR USE IN IMMUNOTHERAPY AGAINST DIFFERENT TYPES OF CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has cancer, comprising administering to said patient a population of activated T cells that kill cancer cells that present a peptide consisting of the amino acid sequence of SEQ ID NO: 47,wherein said cancer is selected from colorectal cancer (CRC), gallbladder cancer (GBC), head and neck squamous cell carcinoma (HNSCC), non-small cell lung cancer (NSCLC), ovarian cancer (OC), and renal cell carcinoma (RCC).
US Pat. No. 10,709,776

METHOD FOR PRODUCING OUTER MEMBRANE VESICLES

CENTRE NATIONAL DE LA REC...

1. An ex vivo method for producing outer membrane vesicles (OMVs) comprisingexpressing or overexpressing a hemolysin F gene (hlyF) in gram-negative bacterium; and
recovering the OMVs from the gram-negative bacterium.

US Pat. No. 10,713,353

SEPARATE CORES TO SECURE PROCESSES FROM SPECULATIVE ROGUE CACHE LOADS

VMware, Inc., Palo Alto,...

1. A method for executing an application on a computing system, the method comprising:executing an operating system (OS) on a first processing core selected from among a plurality of processing cores in the computing system;
translating virtual addresses in a first virtual address space of an application received from the first processing core using a first set of page tables that maps an entire user address space of the application and an entire kernel address space of the OS to a physical memory shared by the plurality of processing cores;
executing the application on a second processing core selected from among the plurality of processing cores in the computing system; and
translating virtual addresses in a second virtual address space of the application received from the second processing core using a second set of page tables that maps the entire user address space of the application and at most only a portion of the kernel address space of the OS to the physical memory.

US Pat. No. 10,711,219

AUTOMOTIVE TRANSMISSION FLUID COMPOSITIONS FOR IMPROVED ENERGY EFFICIENCY

Infineum International Li...

1. A method of improving the fuel economy of a vehicle equipped with an automatic transmission, the method comprising lubricating the automatic transmission with an automatic transmission fluid comprising a major amount of an oil of lubricating viscosity and minor amounts of(a) one or more oil-soluble or dispersible molybdenum-containing compounds selected from the group consisting of molybdenum dithiocarbamates, molybdenum dialkyldithiophosphates, molybdenum alkyl xanthates, molybdenum alkylthioxanthates, and mixtures thereof,
(b) a reaction product of an isomerized alkenyl-substituted succinic anhydride and a polyamine characterized by structure (II):
wherein x and y are independently zero or integers from 1 to 30, where x+y is from 1 to 30, and z is zero or an integer from 1 to 10,(c) an ashless dispersant, and
(d) a metal-containing detergent,
thereby improving fuel economy by at least 0.9% in an FTP-75 test cycle relative to a comparative automatic transmission fluid comprising a major amount of the oil of lubricating viscosity, a minor amount of the reaction product (b), a minor amount of ashless dispersant (c), and a minor amount of metal-containing detergent (d), but no oil-soluble or dispersible molybdenum-containing compound (a),
wherein the automatic transmission fluid further exhibits comparable paper-on-steel (POS) friction and significant reduction in steel-on-steel (SOS) friction, relative to the comparative automatic transmission fluid so as to satisfy one or both of the following:
no more than a 3% reduction in static POS friction, measured using a D600 fiber plate against an SAE1035 tumbled steel plate on a small scale Low Velocity Friction Apparatus (LVFA) at about 80° C., relative to the comparative automatic transmission fluid, and no less than a 12% reduction in dynamic SOS friction, measured on a Falex block-on-ring apparatus according to JASO M358-2005 at about 80° C. and at 0.025 to 1.00 m/s; and/or
no more than a 9% reduction in static POS friction, measured using a D600 fiber plate against an SAE1035 tumbled steel plate on a small scale LVFA at about 80° C., relative to the comparative automatic transmission fluid, and no less than a 17% reduction in dynamic SOS friction, measured on a Falex block-on-ring apparatus according to JASO M358-2005 at about 110° C. and at 0.025 to 1.00 m/s.

US Pat. No. 10,711,216

ESTER COMPOUNDS, LUBRICATING OIL COMPOSITIONS CONTAINING SAME AND PROCESSES FOR MAKING SAME

ExxonMobil Chemical Paten...

1. A compound having a formula (F-I) below:
wherein:
R1 and R2 are independently each a hydrocarbyl group comprising at least 2 carbon atoms; and
R3 is a substituted or unsubstituted hydrocarbyl group.

US Pat. No. 10,710,985

INDOLIN-2-ONE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein
A is phenyl or a five or six membered heteroaryl group, containing one or two N atoms, selected from

or the amide group —C(O)—NR1R2 may form together with two neighboring carbon atoms from the group A an additional fused ring, selected from
R1 and R2 are independently selected from hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, —(CH2)2-lower alkoxy, oxetanyl, cycloalkyl, or CH2-cycloalkyl, which cycloalkyl rings are optionally substituted by halogen;or R1 and R2 may form together with the N atom to which they are attached the group
andR3 is hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,710,929

MINERAL COMPOSITION BASED ON A MIXED SOLID PHASE OF CALCIUM AND MAGNESIUM CARBONATES AND PROCESS FOR PREPARING SUCH A COMPOSITION

S. A. Lhoist Recherche et...

1. A mineral composition containing a mixed solid phase of synthetic calcium and magnesium carbonates, formed of a crystallized calcic portion and a plate-like form crystallized magnesian portion, the crystals of the calcic portion and those of the magnesian portion being aggregated in a form of composite aggregates, these aggregates themselves being at least partly agglomerated in a form of agglomerates, said calcic portion comprising at least one carbonate selected from the group consisting of calcite and the mixtures of calcite and aragonite, said magnesian portion comprising hydromagnesite in the plate-like form, said aggregates being formed of a calcic core on which hydromagnesite plates are aggregated, said mixed solid phase of carbonates of said mineral composition having a thermal conductivity of 25 to 45 mW/Km for a bulk density of 250 kg/m3 or lower and of 80 kg/m3 or higher measured in accordance with standard EN 459.2, and a Ca/Mg molar ratio higher than 1.2 and equal to or less than 4.0.

US Pat. No. 10,710,034

METHOD FOR MIXING GAS INTO HIGH-VISCOSITY MATERIAL AND APPARATUS FOR THE SAME

SUNSTAR ENGINEERING INC.,...

1. A gas mixing apparatus for mixing gas into a high viscosity material, the gas mixing apparatus comprising:a piston pump including a cylinder, a discharge port for gas formed at an end of the cylinder so as to make the cylinder communicate with a conduit through which a high-viscosity material can flow, a suction port formed in the cylinder so as to fill the cylinder with gas, and a piston slidable between a first position and a second position inside the cylinder;
a discharge valve that opens and closes the discharge port,
wherein the cylinder forms a cylinder space having a predetermined volume for filled gas when the piston is located at the first position; and
a controller,
the controller being configured to control the apparatus to execute each of the steps of:
closing the discharge valve;
moving the piston to the first position to form the cylinder space having the predetermined volume;
filling the cylinder space with the gas having the predetermined pressure from the suction port;
moving the piston toward the second position to compress the gas; and
opening the discharge valve to mix the compressed gas into the high-viscosity material that flows through the conduit.

US Pat. No. 10,709,964

BLOCK BUILDING GAME

PROTO. TOYS, INC., Provo...

1. A game system comprising: a platform connected to a tube, the platform comprising: a first planar member, polygonal in shape, the first planar member with a circumferential lip; and a second member, with a same polygonal shape as the first member, in connection with the first member the second member comprising a stop configured to catch the circumferential lip, wherein the first member and second member are movable with respect to each other, wherein the at least a portion of the first planar member may reversibly reside within the second member; a void between the first planar member and the second member, wherein the second member circumferentially surrounds the void and the first planar member resides at least partially within the void; a first configuration wherein the platform is in a first position; and a second configuration wherein the platform is in an unstable second position; an actuator connected to the tube and spaced apart from the platform; an air-chamber within the actuator that when actuated forces air from the actuator to the platform, wherein the air causes the first member and second member to move with respect to each other.
US Pat. No. 10,709,760

TREATMENT OF CHRONIC ULCERS

Promore Pharma AB, Solna...

1. A method of treating a chronic ulcer, wherein said method comprises:(a) topically applying to said chronic ulcer a pharmaceutical formulation, wherein the pharmaceutical formulation is an aqueous solution comprising LL-37 or a pharmaceutically-acceptable salt thereof, wherein the pharmaceutical formulation comprises one thickening agent; followed by
(b) topically applying a dressing to said chronic ulcer;
wherein the dose of LL-37 applied per cm2 of wound area is between about 1 ?g/cm2 and about 70 ?g/cm2, and wherein the pharmaceutical formulation has a viscosity in the range of about 2 and about 10 Pa·s.
US Pat. No. 10,709,765

COMPOSITION FOR INHIBITING SURVIVAL OR GROWTH OF TUBERCLE BACILLUS BY ADJUSTING POLARIZATION OF MACROPHAGE, AND METHOD USING SAME

1. A composition for inhibiting the survival or proliferation of Mycobacterium tuberculosis, the composition comprising:a material inducing the polarization of macrophages into M1 macrophages, and
at least one anti-tuberculosis drug selected from the group consisting of rifampicin, isoniazid, ethambutol, pyrazinamide, and analogues thereof.
US Pat. No. 10,711,312

METHODS FOR IMMUNOTHERAPY-BASED TREATMENT AND ASSESSMENT OF CANCER

The Regents of the Univer...

1. A method of treating a subject having cancer, comprising:a) administering to the subject an anti-PD-1 therapy, wherein the cancer has been determined to not comprise a loss of function mutation or disruption in Janus kinase 1 (JAK1) or Janus kinase 2 (JAK2); or
b) administering to the subject a cancer therapy alternative to that in (a) wherein the cancer has been determined to comprise at least one loss of function mutation or disruption in Janus kinase 1 (JAK1) or Janus kinase 2 (JAK2).

US Pat. No. 10,711,214

PRODUCTION OF A CARBONACEOUS FEEDSTOCK MATERIAL FROM A WASTE CARBON SOURCE

NORTH-WEST UNIVERSITY, P...

1. A process for producing a carbonaceous feedstock material from waste-containing carbon sources, the process including the steps consisting of:(i) introducing a source of a hydrothermal liquefaction biochar product to a source of discard coal fines to form a bio-coal mixture;
(ii) introducing a gasification catalyst additive selected from the group consisting of a source of an alkali metal or a source of an alkaline earth metal to the bio-coal mixture;
(iii) optionally, contacting the bio-coal mixture with a binder; and
(iv) compacting the resulting mixture of step (ii) or (iii) to form one or more carbonaceous feedstock briquettes, the size of said briquettes having a dimension of at least 5 mm.

US Pat. No. 10,710,991

PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES

Syngenta Participations A...

1. A process for preparing a compound of formula X
comprising
i. reacting a compound of formula VII

with triphenylphosphoranyldiene-acetonitrile or (Cyanomethyl)diethoxyphosphine oxide to give a compound of formula VIII

ii. reducing the compound of formula VIII with a suitable reducing agent to give a compound of formula X.

US Pat. No. 10,710,988

PIPERAZINE DERIVATIVE

Astellas Pharma Inc., Ch...

9. A pharmaceutical composition, comprising a compound or salt thereof according to claim 8 and a pharmaceutically acceptable excipient.