US Pat. No. 10,478,184

SYSTEM FOR CONTROLLING A TISSUE-STAPLING OPERATION

Boston Scientific Scimed,...

1. A method of operating an endoscopic stapler including (a) a staple member with one or more staples and (b) an anvil member, comprising:positioning the stapler within a body;
advancing a first pusher unit relative to a first fluid source of a controller operably coupled to the stapler to direct a pressurized fluid through a first conduit to relatively move the staple member and the anvil member towards one another, wherein the controller includes a sensor that measures an amount of pressurized fluid directed through the first conduit based on an amount of time a current supplied by the controller is activated; and
advancing a second pusher unit of the controller relative to a second fluid source to direct a pressurized fluid through a second conduit to eject one or more staples from the staple member.

US Pat. No. 10,478,179

ABSORBABLE FASTENER FOR HERNIA MESH FIXATION

Covidien LP, Mansfield, ...

1. A mesh fastener for penetrating tissue and fixating mesh, the mesh fastener having a longitudinal axis and comprising:a head section with a distal surface and a proximal surface perpendicular to the longitudinal axis, the head section having an outer wall defining an outer diameter, the outer wall having a pair of spaced apart tool engaging flanges defining a pair of open sections and a pair of threaded sections, each open section of the pair of open sections extending from the proximal surface to the distal surface of the head section, the pair of threaded sections being located about 180° from each other, each flange of the pair of spaced apart tool engaging flanges including a single thread having a first pitch formed on an outer surface of a respective one of the pair of spaced apart tool engaging flanges, each thread extending radially to a single peak;
a threaded, truncated tissue snaring section, having a distal and a proximal end, the proximal end of which is formed on the distal surface of the head section,
the threads of the tissue snaring section, having a diameter and root diameter, and extending from the proximal end of the tissue snaring section to the distal end of the tissue snaring section, the threads of the tissue snaring section having a second pitch that is different from the first pitch; and
a sharpened tip extending distally from the tissue snaring section, a distal-most tip of the sharpened tip radially spaced from the longitudinal axis of the mesh fastener,
wherein the fastener is formed of a polymer that exhibits a young's modulus in the range of 150,000 to 2,000,000 PSI.

US Pat. No. 10,478,173

MEDICAL APPARATUS AND METHOD FOR ATTACHING A SUTURE TO A BONE

1. A medical implement for attaching a suture to a bone, comprising:a handle having a proximal end for manual grasping and a distal end for engagement with said bone to which said suture is to be attached, said bone being pre-formed with a first bore, said handle extending axially from said proximal end to said distal end;
a hook extending from the distal end of the handle and configured for reception in said first bore of the bone;
a movable member resiliently coupled to said handle and urged in an axial direction of the handle toward the hook responsive to the resilient coupling, said movable member being movable to a retracted position with respect to the hook to facilitate reception of the hook into said first bore, and biased to an extended position with respect to the proximal end of the handle for clamping said handle to said bone with a resilient force at a predetermined angle with respect to said first bore;
and a manually manipulatable member coupled to said movable member for moving said movable member to said extended and retracted positions;
said handle being formed with a passageway extending longitudinally therethrough from its proximal end to its distal end, said passageway being configured for receiving a drill, for drilling a second bore through said bone at said predetermined angle with respect to said first bore and for passing through the passageway one end of a suture to traverse, and to extend past, said first bore such that said one end of the suture is accessible through said first bore for being pulled out therefrom, while the opposite end of the suture is accessible through said second bore for pulling out therefrom in order to attach the suture to said bone.

US Pat. No. 10,478,170

T-FASTENER SUTURE DELIVERY SYSTEM

C. R. Bard, Inc., Murray...

1. A delivery device, comprising:a housing including a plurality of teeth defining a plurality of pockets on an interior side surface;
a needle extending from a distal end of the housing;
a plurality of T-fasteners, each of the T-fasteners including:
a fastener portion disposed in a lumen of the needle; and
a suture portion extending toward a proximal end of the housing; and
an ejection assembly including:
an actuator designed for reciprocal movement between a first position and a second position, wherein the fastener portion is ejected from a distal end of the needle in the second position; and
an ejector designed for incremental distal movement, the ejector including:
a plurality of teeth designed to engage the actuator; and
an ejector arm designed to engage the plurality of pockets.

US Pat. No. 10,478,160

TECHNOLOGIES FOR CARTILAGE HARVESTING

1. A method comprising:coupling a cutting head onto an actuator, wherein the cutting head is coupled to the actuator via a shaft, wherein the shaft includes a first end portion, a second end portion, and a disc portion, wherein the disc portion is positioned between the first end portion and the second end portion, wherein the first end portion is coupled to the actuator such that the first portion is not visible external to the actuator, wherein the disc portion engages the actuator such that the disc portion is visible external to the actuator, wherein the second end portion is fastened to the cutting head;
applying a force to the cutting head via the actuator; and
cutting a cartilage with the cutting head based on the force.

US Pat. No. 10,478,159

BIOPSY NEEDLE DESIGN

3DBiopsy, Inc., Aurora, ...

1. An apparatus, comprising:a cannula, comprising:
a body extending between a first end and a second end, the body having a first side and an opposite second side; and
a leading edge formed by the first end, the leading edge extending along a first plane, the first plane extending between the first side and second side, the first plane forming a leading edge angle between the intersection of the first side and the first plane;
a mandrel, comprising:
a body extending between a first end and a second end along a central longitudinal axis;
a notch formed by the body, the notch forming a bed extending between the first end and the second end;
a first sample region formed by the bed, the first sample region, comprising:
a first plurality of ridges, wherein each of the first plurality of ridges comprises:
a flank extending from the bed toward the mandrel body second end, the flank terminating at a crest; and
a concave slope descending from the crest;
a second sample region formed by the bed, the second sample region comprising:
a second plurality of ridges, wherein each of the second plurality of ridges comprises:
a flank extending from the bed toward the mandrel body second end, the flank terminating in a crest; and
a concave slope descending from the crest;
a deck disposed between the first plurality of ridges and the second plurality of ridges.

US Pat. No. 10,478,156

IMAGING APPARATUS FOR DIAGNOSIS, METHOD OF CONTROLLING THE SAME, PROGRAM, AND COMPUTER READABLE STORAGE MEDIUM

TERUMO KABUSHIKI KAISHA, ...

1. An imaging apparatus for diagnosis accommodating an imaging core which has an optical transceiver for transmitting light from a light source toward a vascular tissue and for receiving reflected light from the vascular tissue, and reconstructing a blood vessel image based on interference light data obtained by converting into an electric signal interference light in which measurement light obtained by rotating the imaging core by using a catheter which has an open hole at a distal end portion and reference light separated from the light from the light source are synthesized, the imaging apparatus for diagnosis comprising:line data generation means for generating line data in a radial direction from a rotary center position of the imaging core based on the interference light data;
determination means for determining whether or not a foreign substance other than a predetermined liquid enters between the imaging core and an inner surface of the catheter based on distribution of signal strength values in the line data which is generated by the line data generation means; and
display means for displaying a message which indicates that entrance of the foreign substance is detected in a case where a determination result of the determination means indicates the entrance of the foreign substance.

US Pat. No. 10,478,155

ULTRASONIC DEVICE, PROBE, ELECTRONIC INSTRUMENT, DIAGNOSTIC DEVICE, AND PROCESSING DEVICE

Seiko Epson Corporation, ...

13. An ultrasonic device comprising:a piezoelectric element group including a plurality of piezoelectric elements, the piezoelectric elements forming “N” columns arranged along a second direction intersecting with a first direction with each of the “N” columns including a plurality of the piezoelectric elements arranged along the first direction, “N” being a natural number that is equal to or more than 2, each of the piezoelectric elements including a cavity section disposed in a substrate, a membrane covering the cavity section, a first electrode disposed on the membrane, a piezoelectric body disposed on the first electrode, and a second electrode disposed on the piezoelectric body;
a first to an Nth driving electrode lines arranged along the first direction;
a first terminal from which a first driving signal for driving the piezoelectric elements, which is a voltage having an amplitude, is supplied to the piezoelectric elements; and
a second terminal from which a second driving signal for driving the piezoelectric elements, which is a voltage having an amplitude, is supplied to the piezoelectric elements; and
a driving signal output circuit configured to output the first and second driving signals to the first and second terminals, respectively,
an ith driving electrode line among the first to the Nth driving electrode lines being connected to the piezoelectric elements constituting an ith column among the “N” columns, with “i” being a natural number that is equal to or less than “N”, the first terminal being connected to one end of the ith driving electrode line, the second terminal being connected to the other end of the ith driving electrode line,
the driving signal output circuit having an output amplifier, a first variable resistance that is configured to adjust the amplitude of the voltage of the first driving signal and is arranged between the output amplifier and the first terminal, and a second variable resistance that is configured to adjust the amplitude of the voltage of the second driving signal and is disposed between the output amplifier and the second terminal.

US Pat. No. 10,478,154

ULTRASOUND SENSOR ELEMENT, ULTRASOUND SENSOR ARRAY ASSEMBLY, ULTRASOUND TRANSMIT SENSOR ELEMENT, IMAGING DEVICE, ULTRASOUND TRANSDUCER, AND METHOD OF PERFORMING AN ULTRASOUND SCAN

Sharp Kabushiki Kaisha, ...

1. An ultrasound sensor array assembly comprising a two dimensional array of ultrasound sensor elements, each sensor element in the two dimensional array of ultrasound sensor elements comprising:an ultrasound transducer,
a transmit circuit configured to provide an electrical signal to the transducer for output of an ultrasound signal; and
a receive circuit configured to receive an electrical signal from the transducer, based on a received reflected ultrasound signal,
wherein the transmit and receive circuits each comprise one or more thin film transistors;
the sensor array assembly further comprising:
a plurality of transmit delay circuits, wherein each transmit delay circuit is in electrical communication with each sensor element in a row of the array of sensor elements, and wherein the transmit delay circuits are configured to delay a transmit signal to the sensor elements in each row for steering a beam of emitted ultrasound; and
a plurality of receive delay circuits, wherein each receive delay circuit is in electrical communication with each sensor element in a column of the array of sensor elements, and wherein the receive delay circuits are configured to delay a receive signal from the sensor elements in each column for steering the beam of received reflected ultrasound;
wherein the plurality of transmit delay circuits are incorporated into a first driver circuit, and the plurality of receive delay circuits are incorporated into a second driver circuit, and the first and second driver circuits are located external and adjacent to the two dimensional array of ultrasound sensor elements.

US Pat. No. 10,478,151

SYSTEM AND METHOD FOR AUTOMATED MONITORING OF FETAL HEAD DESCENT DURING LABOR

GENERAL ELECTRIC COMPANY,...

1. A method for automatically monitoring fetal head descent in a birth canal, comprising:acquiring, via at least one processor, one or more transperineal ultrasound images corresponding to a birth canal of a patient in labor such that the one or more transperineal ultrasound images comprise at least two structures of interest;
segmenting, via the at least one processor, each of the one or more transperineal ultrasound images into a plurality of neighborhood components;
determining, via the at least one processor, a cost function corresponding to each neighborhood component in the plurality of neighborhood components in each of the one or more transperineal ultrasound images;
identifying, via the at least one processor, the at least two structures of interest in each of the one or more transperineal ultrasound images based on the cost function, wherein the at least two structures of interest comprise a pubic ramus and a fetal head;
measuring, via the at least one processor, an angle of progression between a first line passing through the pubic ramus and a second line extending from an inferior apex of the pubic ramus and tangentially intersecting a contour of the fetal skull;
determining, via the at least one processor, the fetal head descent in the birth canal based on the angle of progression to automatically monitor progression of the fetal head in the birth canal of the patient during labor; and
visualizing the one or more transperineal ultrasound images, the pubic ramus, the fetal head, a tangent point on the fetal head, the angle of progression, the fetal head descent, or combinations thereof on a display, wherein at least the angle of progression is overlaid on the one or more transperineal ultrasound images,
wherein the steps of acquiring the one or more transperineal ultrasound images, segmenting each of the one or more transperineal ultrasound images, determining the cost function, identifying the at least two structures of interest, measuring the angle of progression, determining the fetal head descent, and visualizing are automated steps.

US Pat. No. 10,478,144

X-RAY IMAGING APPARATUS AND IMAGING METHOD USING THE SAME

SHIMADZU CORPORATION, Ky...

1. An X-ray imaging apparatus, comprising:an X-ray irradiation detection element including an X-ray irradiation element that irradiates an X-ray to a subject and an X-ray detection element that detects said X-ray transmitting through said subject;
a table that is enabled to load said subject on a loading plane;
a driving element that relatively moves said table relative to said X-ray irradiation detection element; and
a control element that controls a to move of at least one of said table and said X-ray irradiation detection element by said driving element based on a pre-registered pathway information when imaging said subject;
wherein said control element acquires an information as a representative point that is relative to a location at which said table and said X-ray irradiation detection element suspend moving relative to each other y based on either that a relative moving between said table and said X-ray irradiation element suspends, or that once the relative moving between said table and said X-ray irradiation detection element is suspended and then said relative moving between said table and said X-ray irradiation detection element restarts after said table and said X-ray irradiation detection element are relatively moved by at least one of a manual element and or a driving element, and registers said pathway information based on said acquired representative point.

US Pat. No. 10,478,134

SYSTEMS AND METHODS FOR IMPROVED DIAGNOSTICS FOR NUCLEAR MEDICINE IMAGING

GENERAL ELECTRIC COMPANY,...

1. A method comprising:defining an uncertainty model of a medical imaging system, wherein the uncertainty model is based on a natural-statistics distribution of the medical imaging system;
acquiring image data of a patient from the medical imaging system;
calculating an uncertainty map of the patient based on the uncertainty model and the image data, wherein the uncertainty map represents a collection of realizations that are generated based on the image data and the uncertainty model; and
applying a classification or ranking algorithm to the image data and the uncertainty map to calculate image data classification or ranking of the patient including confidence values,
wherein the realizations are based on simulations of selections from the uncertainty model, the simulations automatically randomize parameters of the medical imaging system to select different image voxel values.

US Pat. No. 10,478,128

HEART RATE DETECTION ARCHITECTURE

PIXART IMAGING INC., Hsi...

13. A heart rate detection device, configured to receive a photoplethysmography (PPG) raw data from a PPG detector and a microelectromechanical systems (MEMS) raw data from a MEMS accelerometer, the heart rate detection device comprising:a PPG hardware module configured to receive the PPG raw data, the PPG hardware module comprising:
a first bandpass filter configured to filter the PPG raw data;
a first conversion module configured to convert the filtered PPG raw data to PPG spectrum values and PPG frequency index; and
a first peak extraction module configured to search PPG peak spectrum values among the PPG spectrum values, and output the PPG peak spectrum values and the PPG frequency index;
a MEMS hardware module configured to receive the MEMS raw data, the MEMS hardware module comprising:
a second bandpass filter configured to filter the MEMS raw data;
a second conversion module configured to convert the filtered MEMS raw data to MEMS spectrum values and MEMS frequency index; and
a second peak extraction module configured to search a MEMS peak spectrum value among the MEMS spectrum values, and output the MEMS peak spectrum values and the MEMS frequency index; and
a microcontroller unit (MCU), electrically coupled to the PPG hardware module and the MEMS hardware module, and configured to estimate a heart rate according to the PPG peak spectrum values, the PPG frequency index, the MEMS peak spectrum values and the MEMS frequency index by
determining a reference index according to a frequency index corresponding to the MEMS peak spectrum value in the MEMS spectrum values,
determining a denoising range according to the reference index,
removing the PPG spectrum values in the PPG spectrum values corresponding to the denoising range to generate denoised PPG frequency data, and
calculating the heart rate according to a PPG peak spectrum value of the denoised PPG frequency data,
wherein the PPG hardware module outputs the PPG peak spectrum values as well as the PPG frequency index and the MEMS hardware module outputs the MEMS peak spectrum value as well as the MEMS frequency index without MCU operation to share loading of the MCU, and
wherein the estimated heart rate is configured to be shown on a display.

US Pat. No. 10,478,123

ELASTIC SENSOR FOR MEASURING VITAL PARAMETERS IN THE AUDITORY CANAL

Cosinuss GmbH, Munich (D...

1. A sensor for measuring a vital parameter in the auditory canal (8) of a person or an animal, comprising:a sensor element fixture (2), which is positionable at least partially in the auditory canal (8),
a sensor element (1), which is connectable to the sensor element fixture (2) and is positionable at least partially in the auditory canal (8), and
a positioning element (3), suitable for positioning the sensor element fixture (2) in the auditory canal (8), wherein at least one end of the positioning element (3) is connectable to the sensor element fixture (2),
wherein the position of the sensor element (1) within the auditory canal (8) is determined by the insertion depth of the sensor element fixture (2) in the auditory canal (8), and
wherein the positioning element (3) exhibits a suitable shape relating to the anatomy of the interior face of the auricle, and is suitable for pushing the sensor element fixture (2) into the interior of the auditory canal such that the sensor is held firmly and a continuous measurement of the vital parameter occurs in the auditory canal (8) characterized in that
the sensor element (1), the sensor element fixture (2) and the positioning element (3) are arranged at least partially in a housing (4) and the housing (4) is adaptable to the anatomy of at least part of the head of the person or the animal, wherein the housing (4) is at least partially elastic, the housing (4) is rotatable and/or size adjustable, the housing (4) comprises a piston and a guide wherein the piston is at least partially aligned in the guide, the piston and/or the guide are arranged with a material comprising a plastic, a rubber, a silicone and/or an elastomer such that they may be pulled apart in the 0° position and such that a rotation of up to ?120° or +120° results in a deadlock, wherein the 0° position lies in a plane parallel to the sagittal plane of the head.

US Pat. No. 10,478,122

MEASUREMENT METHOD AND MEASUREMENT DEVICE FOR BROWN ADIPOSE TISSUE

TOKYO MEDICAL UNIVERSITY,...

1. A measurement method for brown adipose tissue, comprising:a light input step of inputting near-infrared light from a light input unit into a measurement target portion;
a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit;
a calculation step of measuring any one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit;
a defining step in which an index value for a brown adipose tissue amount is defined as the any one value measured; and
a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

US Pat. No. 10,478,121

DEVICE AND METHOD FOR DETERMINING AN INCORRECT POSITIONING IN THE ALIGNMENT OF PROSTHESES

1. A method for determining positions for alignment of a prosthetic foot relative to a lower leg tube as part of an alignment of a lower extremity device, comprising:establishing, using sensor data measured by at least one inertial sensor connected to the lower extremity device, over at least one gait cycle for a treated extremity, at least one of inertial measurement data and variables derived from the inertial measurement data for the treated extremity, the inertial measurement data comprising absolute angles of a lower leg and a thigh of the treated extremity;
determining a knee angle of the lower leg and the thigh from the absolute angles of the lower leg and thigh;
comparing the inertial measurement data and the knee angle with intended values;
determining positions for alignment of the prosthetic foot relative to the lower leg tube based on the comparing.

US Pat. No. 10,478,120

MRI-GUIDED INTRAARTERIAL CATHETER-BASED METHOD FOR PREDICTING TERRITORY OF LOCAL BLOOD BRAIN BARRIER OPENING

The Johns Hopkins Univers...

1. A method of administering a therapeutic agent directly to the brain parenchyma through a compromised region of the blood-brain barrier in a subject having a brain disorder, comprising:disrupting the blood-brain barrier (BBB) at an isolated region by locally administering an effective amount of a hyperosmolar agent at said region using a catheter,
locating an opening in the BBB using non-invasive MR (magnetic resonance) imaging with a contrast agent administered at said isolated region, and
administering a therapeutically effective amount of a therapeutic agent at the located opening in the BBB.

US Pat. No. 10,478,118

METHOD AND DEVICE FOR SLEEP ANALYSIS

Cleveland Medical Devices...

1. A method of remote sleep analysis and diagnosis comprising the steps of:a) providing a patient with a portable patient interface box adapted to be worn by the patient and a nasal cannula or a facemask, a respiratory effort belt and a fingertip pulse oximeter, the patient interface box comprising a battery, at least one kinetic sensor, a nonvolatile digital memory, first and second pressure transducers, a first air port for connecting the nasal cannula or the facemask to the first pressure transducer, a second air port for connecting the respiratory effort belt to the second pressure transducer, and a releasable connector sensor input to electrically connect and disconnect the fingertip pulse oximeter, the nasal cannula or facemask for measuring airflow of the patient, the respiratory effort belt for measuring respiratory effort of the patient, the kinetic sensor for measuring body position or orientation, and the fingertip pulse oximeter for measuring oxygenation of the patient;
b) applying and connecting the nasal cannula or facemask, the respiratory effort belt and the fingertip pulse oximeter to the patient, and further the patient interface box to the patient;
c) measuring and collecting data from the sensors through the patient interface box of the airflow, respiratory effort, body position or orientation and oxygenation of the patient in a remote sleep location from the sleep unit or lab while the patient is attempting to sleep;
d) digitizing and storing the collected data from the patient in the nonvolatile digital memory of the patient interface box;
e) to the sleep analysis unit or lab or to a database accessible to individuals from the sleep analysis unit or lab;
f) providing a computer or processor for analyzing the transferred collected data to identify and draw attention to physiological or technological events in the data indicative of a sleeping disorder; and
g) further analyzing at a minimum the transferred collected data and/or the physiological or technological events in the data at the sleep analysis unit or lab, or at a location remote from the remote sleep location to determine whether the patient suffers from a sleeping disorder.

US Pat. No. 10,478,116

METHODS AND SYSTEMS FOR FEEDING READINESS DIAGNOSIS

University of Florida Res...

1. A method for diagnosing a digestion condition of a subject, the method comprising:obtaining electrogastrogram (EGG), bowel sound, and Near Infrared Spectroscopy (NIRS) signals from an EGG sensor, acoustic sensor and NIRS sensor, respectively, positioned about an abdominal region of a subject;
removing artifacts from the signals to obtain conditioned signal data; and
determining a digestion condition of the subject based at least in part upon the conditioned signal data, wherein determining the digestion condition of the subject comprises identifying an abnormal digestion condition or the location or severity thereof.

US Pat. No. 10,478,111

SYSTEMS FOR SPEECH-BASED ASSESSMENT OF A PATIENT'S STATE-OF-MIND

SRI International, Menlo...

1. A computer-implemented method of improving output of a speech-based state-of-mind detection system, the method comprising:receiving, using the speech-based state-of-mind detection system, a speech pattern collected from a patient;
determining, using the speech-based state-of-mind detection system, at least one feature of the collected speech pattern;
determining, using the speech-based state-of-mind detection system, a presence or absence of a state-of-mind of the patient using a first distribution of a non-lexical speech feature computed over a first time interval in which speech of the patient is collected during a session and a second distribution of the non-lexical speech feature computed over a second time interval in which speech of the patient is collected during the session to indicate a change in the patient from a first state-of-mind to a second state-state-of-mind as a result of the session;
wherein the state-of-mind is defined by a clinical protocol; and
outputting, by the speech-based state-of-mind detection system, the presence or absence of the state-of-mind to the patient, a clinical expert, or both the patient and the clinical expert.

US Pat. No. 10,478,106

PROBE, SYSTEM, AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES

1. A measuring probe for non-invasive in vivo measurement of blood analytes by Raman spectroscopy, the measuring probe comprising a housing having a skin engaging surface for engaging a subject's skin, the housing comprising:a first optical system comprising light guiding optics configured to direct source light, as a collimated beam, to the skin engaging surface and further configured to cause penetration of the subject 'skin with said collimated beam, for interacting of the collimated beam with the blood analytes, wherein angles between rays of light in the collimated beam are within a threshold value of 10 degrees; and
a second optical system configured to collect scattered Raman light, obtained from scattering of the collimated beam by the blood analytes, for use in measurement of the blood analytes;
wherein the first optical system is configured to direct the collimated beam at an oblique incidence angle with respect to a normal incidence angle of the skin engaging surface; and
wherein the second optical system is configured to spatially separate the scattered Raman light from a specular reflection of the collimated beam from the subject's skin.

US Pat. No. 10,478,105

EXTRACORPOREAL CIRCULATION MANAGEMENT DEVICE AND EXTRACORPOREAL CIRCULATION DEVICE HAVING IT

TERUMO KABUSHIKI KAISHA, ...

1. An extracorporeal circulation management device comprising:first controller means programmed for determining a plurality of first oxygenation-related parameter values of blood supplied from an output of an oxygenator unit that carries out gas exchange of blood to a target person with time-course information and for determining a plurality of second oxygenation-related parameter values of blood introduced from the target person into an input of the oxygenator unit with time-course information;
calculation means programmed for determining in-body passing time information defining a time period for blood supplied from the output of the oxygenator unit to the target person to be discharged from the target person according to a bloodstream volume of the target person and a flow rate of the supplied blood; and
second controller means programmed for selecting first oxygenation-related parameter values separated by the stored in-body passing time information and for selecting second oxygenation-related parameter values separated by the calculated in-body passing time information as comparison targets to evaluate oxygenation consumption of the target person;
wherein the calculation means is further programmed to correct the in-body passing time information according to locations on the target person where the blood is introduced from the oxygenator unit into the target person and where the blood is discharged from the target person.

US Pat. No. 10,478,102

NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS

MEDTRONIC MINIMED, INC., ...

1. A method of covering an introducer needle comprising:providing a sensor hub, a sensor, and an introducer, the introducer being configured to insert the sensor into a patient, the introducer comprising:
a housing detachably connectable to the sensor hub, wherein the sensor hub contains the sensor prior to connection to the housing, the housing including a needle cover, wherein the needle cover is an internal compartment of the housing;
a needle that is moveable with respect to the needle cover and is extendable out of, and retractable into, the housing;
a needle holder connected to the needle and contained within the housing; and
a spring having a top end in contact with the needle holder and a bottom end in contact with the housing,
wherein said needle holder and spring are configured such that, when the housing is connected to the sensor hub, said spring is in a compressed position and the needle extends out of the housing to insert the sensor into the patient, and such that disconnection of the housing from the sensor hub causes said spring to expand, thereby retracting the needle into the housing to be covered by said needle cover inside the housing, and the sensor remaining inserted in the patient;
wherein the housing includes a mating component to mate with the sensor hub and hold said spring in said compressed position when the housing is connected to the sensor hub; and
wherein the mating component includes a lock that locks the needle holder into a needle extended position when the housing is connected to the sensor hub, and when the mating component is not mated with the sensor hub the housing is completely detached from the sensor hub;
connecting the housing to the sensor hub so as to insert the sensor into the patient; and
disconnecting the housing from the sensor hub, whereby the needle cover covers the needle when the housing is detached from the sensor hub.

US Pat. No. 10,478,098

INFORMATION PROCESSING SYSTEM

FUJI XEROX CO., LTD., To...

20. An information processing system comprising:a sheet that is usable in a use mode which is any one of an underlay mode and a cover mode;
a determination unit that determines that the sheet is in one of a state in which the sheet is used in the underlay mode, a state in which the sheet is used in the cover mode, and a state in which the sheet is not used, based on data detected by one or more sensors provided in the sheet; and
a unit that calculates a time during which a user is seated based on a length of time in which the sheet is determined to be used in the underlay mode or the cover mode by the determination unit.

US Pat. No. 10,478,095

SYSTEM AND METHOD FOR REAL-TIME PERSONNEL FATIGUE LEVEL MONITORING

Dharma P. Agrawal, Cinci...

1. A system for embedding in a shoe and monitoring fatigue level of a subject, wherein said shoe having a sole, comprising:a plurality of sensors disposed in the shoe sole;
a micro-controller communicatively connecting to said plurality of sensors and configured to receive readings of said plurality of sensors, and is further configured to validate the readings of a first sensor of the plurality of sensors with readings of a second sensor, wherein the first sensor of the plurality of sensors is a ball tilt sensor configured to detect orientation of the subject to generate first sensor data and the second sensor is an accelerometer configured to generate second sensor data used to reduce an error in the first sensor data; and
a wireless interface communicatively connecting to said micro-controller and configured to send the readings of said plurality of sensors wirelessly to a base station, wherein said base station determines the fatigue level of the subject based on at least a portion of the readings of said plurality of sensors transmitted by the wireless interface.

US Pat. No. 10,478,091

METHOD AND DEVICE FOR DETECTING POSITION OF MICRO ROBOT USING ULTRA WIDE-BAND IMPULSE RADAR SIGNAL

Electronics and Telecommu...

1. A method of detecting a position of a micro robot, the method comprising:emitting an ultra wide-band impulse radar signal to a space in which a micro robot is;
driving the micro robot with electromagnetic field;
using a reflected signal of the ultra wide-band impulse radar signal to detect a natural oscillating resonance frequency signal generated when the micro robot is driven, to extract a micro robot signal;
analyzing the micro robot signal to calculate position information for the micro robot,
acquiring a real-time image data for a subject where the micro robot is inserted; and
performing position correction on the calculated position information based on pre-stored reference image and the real-time image data.

US Pat. No. 10,478,090

SPECTRAL BIN UN-ALIASING FOR REDUCED FIELD-OF-VIEW MAGNETIC RESONANCE IMAGING NEAR METAL IMPLANTS

Medical College of Wiscon...

1. A magnetic resonance imaging (MRI) system comprising:a MRI scanner, including a plurality of radio frequency (RF) receivers, for imaging objects of interest;
at least one processor; and
a memory, with computer code instructions stored thereon, the computer code instructions, when executed by the at least one processor, cause the at least one processor to:
cause the MRI scanner to perform a first scan, on an anatomy region including an implant, according to a first field of view to acquire first multi-spectral MRI data associated with a plurality of frequency bins;
compute, for each pair of a single RF receiver and a single frequency bin, a respective spectral sensitivity map using at least a portion of the first multi-spectral MRI data;
cause the MRI scanner to perform a second scan according to a second field of view to acquire second multi-spectral MRI data associated with the plurality of frequency bins, the second field of view smaller than the first field of view; and
reconstruct one or more MRI images according to the second field of view using the second multi-spectral MRI data and the spectral sensitivity maps.

US Pat. No. 10,478,084

ELECTROCARDIOGRAM SIGNAL DETECTION

AliveCor, Inc., Mountain...

1. A method of filtering a sensed electrocardiogram (ECG), comprising:identifying a QRS interval in the sensed ECU;
identifying a PQ interval in the sensed ECG;
identifying an ST interval in the sensed ECU;
filtering the QRS interval using, a first filtering regime to generate a filtered QRS interval;
filtering both the PQ and ST intervals with a second filtering regime to generate filtered PQ and ST intervals; and
combining the filtered QRS interval and the filtered PQ and ST intervals.

US Pat. No. 10,478,083

EXTENDED WEAR AMBULATORY ELECTROCARDIOGRAPHY AND PHYSIOLOGICAL SENSOR MONITOR

Bardy Diagnostics, Inc., ...

1. An extended wear electrocardiography and physiological sensor monitor recorder, comprising:a sealed housing having a rounded isosceles trapezoid shape with substantially straight edge on a proximal end that is longer than a substantially straight edge on a distal end and configured to be removably secured into a receptacle on an electrode patch that comprises a battery electrically interfaced to a pair of electrical pads on the receptacle;
a set of electrical contacts that protrude from a bottom surface of the proximal end of the sealed housing and correspond with further electrical pads on the receptacle;
a patient feedback button located on the proximal end of the sealed housing on a surface opposite the electrical contacts on the bottom surface; and
electronic circuitry comprised within the sealed housing, comprising:
an electrographic front end circuit operable to sense electrocardiographic signals through electrocardiographic electrodes provided on the electrode patch;
a micro-controller electrically interfaced to the electrocardiographic front end circuit and operable to execute under micro-programmable control to sample the electrocardiographic signals sensed by the electrocardiographic front end circuit, to stage each electrocardiographic signal sample in a buffer, to compress each of the staged electrocardiographic signal samples, to further buffer each of the compressed electrocardiographic signal samples, and to write the buffered electrocardiographic signal samples to memory; and
a flash memory electrically interfaced with the micro-controller and operable to store the buffered samples of the electrocardiographic signals.

US Pat. No. 10,478,078

DEVICE AND METHOD FOR DETERMINING VITAL SIGNS OF A SUBJECT

KONINKLIJKE PHILIPS N.V.,...

1. A device for determining vital signs of a subject comprising:a controller with a memory that stores instructions;
a processor that executes the instructions, wherein, when executed by processor, the instructions cause the controller to execute a process comprising:
receiving a periodic photoplethysmographic (PPG) signal obtained from a subject by a PPG measurement;
partitioning the PPG signal in time into a plurality of PPG sub-signals respectively covering a half period of the PPG signal;
normalizing in time and/or amplitude the PPG signal in advance of the partitioning and/or the PPG sub-signals to obtain normalized PPG sub-signals;
combining the normalized PPG sub-signals to obtain one or more combined PPG sub-signals; and
deriving a desired vital sign of the subject from the one or more combined PPG sub-signals or an enhanced PPG signal obtained by consecutively arranging a plurality of the combined PPG sub-signals.

US Pat. No. 10,478,074

METHOD FOR DETERMINING PATIENT SUITABILITY FOR A SURGICAL PROCEDURE

1. A method for determining a patient's suitability for a proposed surgical procedure, comprising:producing a patient specific hemodynamic calculation parameter set using the optimizing method comprising:
obtaining a generic hemodynamic calculation parameter set;
producing a measured, first situation, hemodynamic profile of said patient by measuring one or more hemodynamic parameters of said patient in a first situation;
producing a simulated, first situation, hemodynamic profile of said patient, using said generic hemodynamic calculation parameter set, and a hemodynamic simulation module;
comparing said measured, first situation, hemodynamic profile to said simulated, first situation, hemodynamic profile; and
based on said comparison, adjusting said generic hemodynamic calculation parameter set to produce an adjusted, hemodynamic calculation parameter set;
producing a further simulated, first situation, hemodynamic profile of said patient, using said adjusted hemodynamic calculation parameter set and said hemodynamic simulation module;
comparing said measured, first situation, hemodynamic profile to said further simulated, first situation, hemodynamic profile; and
repeating the previous three steps until a sufficiently good agreement is reached between said profiles, then designating the final adjusted hemodynamic calculation parameter set as the patient specific hemodynamic calculation parameter set;
using said patient specific hemodynamic calculation parameter set, and said hemodynamic simulation module, operable on a digital processor, to automatically produce a simulated, procedure specific, hemodynamic profile of said patient; and
evaluating said simulated, procedure specific, hemodynamic profile to determine if said patient is a suitable candidate for said surgical procedure.

US Pat. No. 10,478,067

IMPLANTABLE SENSING DEVICES AND ANCHORING METHODS THEREFOR

Integrated Sensing System...

1. A sensor assembly comprising:a sensing device comprising a housing having at least one internal cavity and a transducer and electrical circuitry within the at least one internal cavity, the sensing device further comprising an antenna that is within the at least one internal cavity or outside the housing, the housing having at least one additional housing portion in which the transducer, the electrical circuitry, and the antenna are not located; and
an anchor for securing the sensing device within a living body, the anchor having an axis, a proximal end, a distal end axially spaced apart from the proximal end, and first and second rings that are axially spaced apart, surround the axis, and define flanges that extend radially from the axis, the anchor having metallic portions and optionally nonmetallic portions, at least one of the first and second rings being a first metallic portion of the metallic portions of the anchor and circumscribing the at least one additional housing portion so as not to surround the transducer, the electrical circuitry, or the antenna, wherein the antenna is not circumscribed by any of the metallic portions of the anchor.

US Pat. No. 10,478,065

SYSTEMS AND METHODS FOR MONITORING SUBJECTS IN POTENTIAL PHYSIOLOGICAL DISTRESS

adidas AG, Herzogenaurac...

1. A portable monitoring apparatus for real-time monitoring of an ambulatory subject, comprising:a wearable item comprising a sensor, the sensor providing a sensor signal responsive to the physiology of an ambulatory subject wearing the item; and
a portable data unit local to the wearable item comprising a processing device configured to:
retrieve and process the sensor signal in order to determine physiological information comprising an indication of whether a physiological state of the subject is normal or not or an indication of whether a physiological state of the subject is acceptable or not,
present to the subject items selected from said physiological information, and to
transmit items selected from the physiological information from the portable data unit to a remote monitoring station in dependence on the physiological state of the monitored subject,
wherein the processing device is further configured to direct the transmission, wirelessly to the remote monitoring station, which is a current remote monitoring station selected from two or more candidate remote monitoring stations,
wherein the processing device is further configured to select a new remote monitoring station from the candidate remote monitoring stations that is different from the current remote monitoring station; and is configured to direct future wireless transmissions to the new remote monitoring station and cease directing future wireless transmissions to the current remote monitoring station,
wherein the candidate remote monitoring stations are assigned priorities, and wherein the new remote monitoring station currently has the greatest priority at portable data unit of the other candidate monitoring stations,
wherein the physiological state is further determined by comparing a value of a physiological parameter to a predetermined threshold value that is acceptable or normal based on predetermined criteria.

US Pat. No. 10,478,060

OPHTHALMIC IMAGE PROCESSING APPARATUS AND OPHTHALMIC IMAGING APPARATUS

TOPCON CORPORATION, Itab...

1. An ophthalmic image processing apparatus comprising:a storage unit configured to store image data acquired through scanning a subject's eye using optical coherence tomography;
a first brightness profile generation unit configured to generate a first brightness profile along a first direction by integrating brightness values of the image data;
a second brightness profile generation unit configured to process the first brightness profile to generate a second brightness profile; and
a brightness correction unit configured to perform brightness correction of the image data based on the first brightness profile and the second brightness profile,
wherein the image data is front image data generated based on three-dimensional image data formed by arranging a plurality of B mode images in the first direction, each of the plurality of B mode images lying along a second direction orthogonal to the first direction, and
wherein the front image data corresponds to slice areas of the plurality of B mode images.

US Pat. No. 10,478,059

IMAGING APPARATUS

CANON KABUSHIKI KAISHA, ...

1. An imaging apparatus comprising:a light source configured to emit light while sweeping a wavelength of the light;
an interference unit configured to split the light emitted from the light source into illumination light that is incident on a fundus and reference light and to generate interference light obtained by reflection light reflected from the fundus on which the illumination light is incident interfering with the reference light;
a scan unit configured to scan the illumination light across the fundus;
a detector configured to detect the interference light generated by the interference unit;
a converter configured to convert an analog signal generated from the interference light detected by the detector into a digital signal;
a clock generator configured as an interferometer including an optical path through which part of the light emitted from the light source passes, the optical path being split into a first optical path and a second optical path having an optical path length difference relative to the first optical path, to generate a clock used by the converter sampling the analog signal; and
a processor including a tomographic image obtaining unit configured to obtain a tomographic image of the fundus by using the digital signal converted from the analog signal sampled by the converter in accordance with the generated clock, wherein
the scan unit is configured to scan the illumination light across the fundus over a scan angle equal to or larger than 47 degrees in air,
the tomographic image obtaining unit is configured to obtain a tomographic image of the fundus at a distance equal to or larger than 4.0 mm within an eyeball in a depth range, and
the clock generator is configured so that the optical path length difference is equal to or larger than 22/n mm in air in a case where the generated clock has a frequency n times a frequency of the interferometer corresponding to the optical path length difference, n being an integer equal to or larger than 1.

US Pat. No. 10,478,048

SYSTEM AND METHOD FOR USING A CAPSULE DEVICE

Ankon Medical Technologie...

1. A magnetic capsule system to examine a GI track of a patient, comprising:a first external magnetic control system,
the first external magnetic control system comprising
a first magnetic field generation means, positioned on a first side of the patient, configured to provide a first magnetic field to move a magnetic capsule;
and a first external magnetic movement control assembly, comprising
a first horizontal translation means which can move the first magnetic field generation means along an x-axis direction;
a second horizontal translation means which can move the first magnetic field generation means along an y-axis direction;
a first vertical movement means which can move the first magnetic field generation means along a z-axis direction;
a first rotation means which can turn the first magnetic field generation means and a first magnetic dipole generated by the first magnetic field generation means along or parallel to a xy plane defined by the x-axis and y-axis, or rotate around the z-axis direction;
a second rotation means which can turn first magnetic field generation means and the first magnetic dipole around the x-axis direction;
wherein each of translation, movement and rotation means in the first external magnetic movement control assembly can perform their actuations of the first magnetic field generation means individually;
a second external magnetic control assembly, comprising
a second magnetic field generation means, positioned on a second side of the patient, configured to provide a second magnetic field to move the magnetic capsule;
a third horizontal translation means which can move the second magnetic field generation means along the x-axis direction;
a fourth horizontal translation means which can move the second magnetic field generation means along the y-axis direction;
a second vertical movement means which can move the first magnetic field generation means along the z-axis direction;
a third rotation means which can turn the second magnetic field generation means and a second magnetic dipole generated by the second magnetic field generation means along or parallel to the xy plane defined by the x-axis and y-axis, or rotate around the z-axis direction;
a fourth rotation means which can turn the second magnetic field generation means and second magnetic dipole around the x-axis direction;
wherein each of translation, movement and rotation means in the second external magnetic movement control assembly can perform their actuations of the second magnetic field generation means individually; and
wherein the first and external magnetic control assemblies can operate sequentially or simultaneously to each adjust at least one translation, movement or rotation means of the first or second external magnetic control assemblies to provide a combined magnetic field change experienced by the magnetic capsule, which results in a change in either position or orientation of the capsule inside the patient.

US Pat. No. 10,478,038

POWER MOP

Wessol, LLC, Fort Mill, ...

1. A power mop, comprising:(a) a tank for holding a liquid and adapted to be positioned for gravity-induced flow of the liquid, and including a gravity feed conduit for transporting the liquid from the tank;
(b) a hand grip containing a liquid inlet communicating with the gravity feed conduit for receiving the gravity-induced flow of the liquid from the tank, a valve for controlling the flow of the liquid from the tank to a pump located downstream from the valve for providing flow pressure to the liquid, a battery for powering the pump, and a switch accessible external to the hand grip for powering the pump and switching the valve between open and closed liquid flow positions;
(c) a handle tube connected to the hand grip containing a pressure feed conduit for receiving pressurized flow of the liquid from the hand grip;
(d) a nozzle mounted on the handle tube and adapted to disperse the liquid onto a surface to be mopped; and
(e) a mop head attached on an end of the handle tube remote from the hand grip.

US Pat. No. 10,478,037

METHOD FOR OPERATING A FLOOR-CLEANING DEVICE AND FLOOR-CLEANING DEVICE

robart GmbH, Linz (AT)

1. A method for operating a self-propelling and self-steering floor-cleaning device, wherein at least one map of at least one room to be cleaned is stored in a storage unit of the floor-cleaning device, as is a user-predeterminable cleaning plan having one or more cleaning tasks, wherein at least one cleaning task is associated with a particular room that is identifiable from the at least one map, and the floor-cleaning device is placed in a room, the method comprising:when the cleaning plan is executed, analyzing, with a control unit of the floor-cleaning device, at least one sensor signal of a sensor unit of the floor-cleaning device for features indicative of the room the floor-cleaning device is in;
checking for presence of the features in the at least one map stored in the storage unit; and
determining whether the room in which the floor-cleaning device is placed is the particular room;
wherein, if the result of this determination is negative, performance of the cleaning task associated with the particular room is not carried out, is interrupted or is ended.

US Pat. No. 10,478,036

CLEANER

LG Electronics Inc., Seo...

1. A cleaner comprising:a suction unit that is configured to suction air and dust;
a main body having a front portion that is connected to the suction unit, the main body including:
a dust separation unit that is configured to separate dust from air suctioned through the suction unit, and
a dust container that is configured to receive the dust separated by the dust separation unit, at least a portion of the dust container being transparent or translucent;
a handle unit connected to a rear portion of the main body and configured to receive a battery;
a suction motor disposed in the main body and configured to generate suction force;
wires that connect the suction motor to the handle unit; and
a cover member that is coupled to the main body and located between the dust container and the wires, the cover member covering at least a portion of the transparent or translucent portion of the dust container to thereby prevent the wires from being seen from outside through the dust container.

US Pat. No. 10,478,031

CLEANER

LG Electronics Inc., Seo...

1. A cleaner comprising:a suction unit;
a suction motor that is configured to drive an impeller and is configured to generate suction force to thereby suction air through the suction unit;
a dust separation unit that is configured to separate dust from air suctioned through the suction unit, the dust separation unit including a first cyclone unit configured to separate dust from air that is suctioned into the cleaner through the suction unit, and a second cyclone unit configured to separate dust from air that is discharged from the first cyclone unit;
a dust container that is disposed vertically under the suction motor and configured to receive the dust separated by the dust separation unit;
a battery disposed at a side of the cleaner and configured to supply power to the suction motor; and
a handle disposed at a portion of the battery,
wherein a rotational axis of the impeller extends in a vertical direction and passes through the dust separation unit, and
wherein the suction motor is positioned between the impeller and the second cyclone unit.

US Pat. No. 10,478,027

TOILET SEAT DEVICE AND TOILET DEVICE EQUIPPED THEREWITH

TOTO LTD., Kitakyushu-Sh...

1. A toilet seat device comprising:a toilet seat;
a toilet seat open/close sensor which senses whether the toilet seat is in an opened state or a closed state;
a Doppler sensor using radio waves; and
a controller,
the controller being capable of performing
a room-entering determination process of sensing approach of a user to the toilet seat based on a sensing signal outputted from the Doppler sensor,
a usage determination process of determining urination when it is sensed that the toilet seat is in the opened state, after the room-entering determination process, based on a sensing signal outputted by the toilet seat open/close sensor,
a leaving determination process of sensing that the user leaves from the toilet seat, after the use determination process, based on the sensing signal outputted by the Doppler sensor, and
an post-use operation process of outputting a flushing signal for flushing a bowl part of a toilet stool after the leaving determination process,
the controller performing the post-use operation process when it is sensed by the leaving determination process that the user leaves from the toilet seat after determining urination in the usage determination process,
the controller not performing the post-use operation process when it is sensed by the leaving determination process that the user leaves from the toilet seat after not determining urination in the usage determination process.

US Pat. No. 10,478,021

UTILITY WASH CLOTH

1. A reusable handheld implement comprised of:a backing, multiple strands and a perimeter;
(A) the backing is flat and made of a water resistant or waterproof material; the mentioned backing is perforated, allowing the backing to be permeable; and where the backing has a thickness that minimizes the volume of said perforations;
and,
(1) the backing is pliable,
(2) perforations are located throughout the backing,
(3) perforations are adjacent to the strands,
(B) the strands are soft and not opened looped; the mentioned strands have an overall smooth surface; the strands are connected to the backing in a manner that allows each strand to have a top end that is vertical or vertically aligned to its bottom end;
and,
(1) the strands are pliable,
(2) the length of each individual strand is not greater than 1 inch,
(3) the diameter of each individual strand is not greater than 1 inch,
(4) the strands are not spaced more than 1 inch apart on any surface of the backing comprised of said strands.

US Pat. No. 10,478,018

JUICER

FOSHAN CITY SHUNDE JUTIAN...

1. A juicer comprising a base part, a juicer body, a strainer, a threaded cutter and a feed inlet, wherein the base part is provided with a drive shaft, the juicer body is arranged on the base part, the strainer is arranged within the juicer body, the juicer body is covered over with the feed inlet and a squeezing chamber is formed between the feed inlet and the strainer, the threaded cutter is installed inside the squeezing chamber and is connected with the drive shaft, the threaded cutter comprises a screw body and a thread line formed on external surface of the screw body;the feed inlet is provided at its lower portion with a protruding part which protrudes along one side thereof, a buffer chamber is formed between the upper portion of the threaded cutter and the protruding part, a pivot joint is arranged at the top of the screw body and the pivot joint is pivotally connected to the top of the protruding part, and the upper portion of the screw body from bottom to top is tapered at first and then broadened so as to form a radial projecting top;
wherein a cutter is provided on the inner wall of the upper portion of the feed inlet, a pluggable push-off arm is further provided within the upper portion of the feed inlet, and a guide groove which allows the cutter to be inserted from its bottom is arranged on the push-off arm at a position opposite the cutter.

US Pat. No. 10,478,004

GRILLING PAN FOR COOKING PROTEINS

G.S. Blodgett Corporation...

1. A device for cooking proteins, comprising:a first pan comprising a first base and a first alignment wall, and a second pan comprising a second base and a second alignment wall,
wherein the first base and the second base each include a top surface that includes a non-stick coating,
wherein the first alignment wall is disposed in surface-to surface contact with the top surface of the first base and the second alignment wall is disposed in surface-to-surface contact with the top surface of the second base,
wherein, in use, the first and second bases are aligned such that an exposed planar surface of the first alignment wall makes surface-to-surface contact with an exposed planar surface of the second alignment wall,
wherein each of the first and second alignment walls further comprise a plurality of cutouts that expose the top surface of the respective first and second bases, and the plurality of cutouts in the first alignment wall are disposed in registration with the plurality of cutouts of the second alignment wall when the first and second alignment walls make surface-to-surface contact with each other,
wherein cutouts of the plurality of cutouts of the respective first and second alignment walls are isolated from each other so as to block a food product from flowing from one cutout to another cutout of the plurality of cutouts, and
wherein each of the plurality of cutouts in the first and second alignment walls include a void that extends from the respective cutout to a side edge of the respective alignment wall, and the top surface of the respective first or second base is exposed below each void.

US Pat. No. 10,478,002

SYSTEM FOR THE RITUAL AND GESTURAL LIGHTING OF ELECTRICAL OR ELECTRONIC LIGHT SOURCES

Patrizio Pisani, Rome (R...

1. A system comprising:at least two optical units (100) for ritual-gestural control of sending and receiving of commands between devices, said commands including at least device turning on and device turning off, said devices each being provided with one of said at least two optical units (100),
each said optical unit (100) comprising:
at least one upper part (100.b), the at least one upper part (100.b) comprising at least one cover (104) provided with an opening, a coating (102) that limits optical radiation, and an optical guide (101), the optical guide (101) being made of vitreous material or plastic material; and
at least one lower part (100.a) containing electric, electronic and electromechanical components and circuitry, said electric, electronic and electromechanical components and circuitry comprising:
i) at least one photo-emitter device (105),
ii) at least one photo-detector device (107) optimized for detection of an emission spectrum of the at least one photo-emitter device (105), and
iii) at least one processing and control unit (110) provided with:
a) a management and control circuitry (110.2),
b) at least one connection and control section (110.4) for a power supply source, and
c) at least one acquisition, processing and control unit (110.1) configured for managing input and output, storing digital data in volatile and non-volatile form, managing timing, driving the at least one photo-emitter device (105), acquiring a state of the at least one photo-detector device (107), and controlling the management and control circuitry (110.2),
wherein at least one of the optical units (100) comprises at least one optical filter (104.a) in the opening of the at least one cover (104), the at least one optical filter (104.a) adapted to limit an optical spectrum outside the emission spectrum of the at least one photo-emitter device (105), and
wherein at least one of the optical units (100) comprises, at a base of the optical guide (101), at least one area (101.a) of maximum optical coupling and minimum dispersion.

US Pat. No. 10,478,000

INSULATED CUP WITH DOUBLE WALL CONSTRUCTION

1. A cup comprising:a cup body made of synthetic resin and having a containing part with an opening being open upward and having a relatively large diameter to be able to receive a beverage or food; and
a cup holder made of synthetic resin and fitted on the cup body from an end opposite the opening of the cup body, with a portion except for an upper end and a lower end thereof spaced a predetermined gap from an outer side of a containing part of the cup body,
wherein the cup body has:
a holder top seat extending downward a predetermined length from the opening and stepped such that a diameter thereof decreases downward, and having an inclined fastening groove having a diameter decreasing upward, on an outer side thereof;
a containing part-inclined surface extending downward from the holder top seat such that a diameter thereof decreases downward, having a containing part for receiving a beverage or food, and having an outer side inclined at a predetermined angle from an upper portion integrally extending from the holder top seat and a lower end forming the containing part; and
three or more anti-sticking protrusions formed with regular angular intervals around an inner side of the containing part at a predetermined distance from the opening of the cup body toward a bottom of the containing part, with the outer side forming the containing part of the cup body maintained at a predetermined angle, in order to support a bottom of a second cup holder inserted in the containing part of the subject cup body when a second cup composed of the second cup holder and a second cup body is stacked, and
the cup holder has:
a pipe-shaped grip inclined with a predetermined length such that a diameter thereof decreases downward, and having an inclined fitting portion formed such that a diameter of an inner side of the cup holder decreases upward to correspond to the inclined fastening groove formed on the outer side of the holder top seat of the cup and to be in close contact with the inclined fastening groove; and
a bottom seating protrusion protruding inward from a lower end of the grip of the cup holder to be in close contact with a lower portion of the cup body and having air holes formed with regular angular intervals so that external air flows between the outer side of the containing part of the cup and the grip of the cup holder.

US Pat. No. 10,477,996

ANTI-SPILL DISPOSABLE DRINK THROUGH CUP LID

11. A disposable straw-and-lid combination comprising:a straw having a diameter; and
a round lid having
a raised top having a full circular circumference,
an outer wall extending down from the full circular circumference of the raised top,
an oval opening in the raised top located adjacent to the full circular circumference, the oval opening spanning at least 0.6 inches,
the raised top having a flat upper surface horizontally extending directly from adjacent the oval opening, around the round lid adjacent to the full circular circumference, and back to adjacent the oval opening,
an unperforated conical structure extending downward from the oval opening in the raised top to a circular opening in the conical structure, the circular opening having a diameter smaller than or equal to the diameter of the straw,
the conical structure having an unperforated side wall that transitions from an oval shape at the oval opening to a circular curvature portion adjacent the circular opening and is configured to guide the straw into the circular opening when the round straw is inserted into the oval opening.

US Pat. No. 10,477,994

SYSTEM AND METHOD FOR LOCATION BASED EXCHANGES OF DATA FACILITIATING DISTRIBUTED LOCATIONAL APPLICATIONS

1. A beaconing data processing system, comprising:one or more processors;
a Bluetooth communications interface; and
a memory coupled to the one or more processors, wherein the one or more processors access the memory and control operations of the beaconing data processing system, the operations comprising:
periodically beaconing outbound a broadcast unidirectional wireless data record communicated through the Bluetooth communications interface to serve as a physical location reference contributing to physical location determination processing of one or more user carried mobile data processing systems in a Bluetooth wave spectrum range vicinity of the beaconing data processing system, the beaconing data processing system:
not soliciting an inbound communication to the beaconing data processing system from the one or more user carried mobile data processing systems in response to a receipt of the broadcast unidirectional wireless data record in the one or more user carried mobile data processing systems, and
not configured to process inbound communications resulting from the receipt of the broadcast unidirectional wireless data record in the one or more user carried mobile data processing systems, the broadcast unidirectional wireless data record communicated through the Bluetooth communications interface to serve as the physical location reference including:
no physical location coordinates of the beaconing data processing system,
a data field containing a signal strength of the beaconing data processing system, and
application identifier data stored in the memory.

US Pat. No. 10,477,991

ACCESSORY ORGANIZING AND STORAGE APPARATUS

1. An accessory organizing and storage apparatus, comprising:a housing having a top inner surface and a bottom inner surface, said housing includes a front opening that is covered by one door;
said door includes an inner door surface having a width, a front edge and a rear side, said inner door surface extending rearwardly a predetermined amount from said front edge;
at least one horizontal panel mounted along the width of said inner door surface, said at least one horizonal panel mounted perpendicularly to said door within said inner door surface, said at least one horizontal panel protruding from said rear side towards said front edge until said at least horizontal panel is flush with said front edge, said at least one horizontal panel defining a storage space thereon, said at least one horizontal panel having a ring holding assembly mounted thereon, said ring holding assembly being mounted entirely above said at least one horizontal panel, said ring holding assembly including an elongated base with extension members rising entirely from said base, said extension members being interconnected to said base, said elongated base and said extension members being flush with said front edge, said extension members tapering upwardly, said extension members configured to receive and hold at least one ring, said storage space extending therebetween said ring holding assembly and said rear side of said inner door surface, said storage space being able to hold additional accessories thereon, said extension members remain within a periphery of said inner door surface;
said top inner surface includes at least one top pair of guiding blocks rigidly and immovably mounted there and said bottom inner surface includes at least one bottom pair of guiding blocks rigidly and immovably mounted thereon, said at least one top and bottom pair of guiding blocks longitudinally extending entirely along said top inner surface and said bottom inner surface, respectively;
a top channel runs between said at least one top pair of guiding blocks, a bottom channel runs between said at least one bottom pair of guiding blocks, said top channel has a depth extending from said top inner surface a predetermined distance corresponding to a height of said at least one top pair of guiding blocks, said bottom channel has a depth extending from said bottom inner surface a predetermined distance corresponding to a height of said at least one bottom pair of guiding blocks;
at least one vertical panel that includes a front face and a rear face, said front and rear face include a top end that is held between said at least one top pair of guiding blocks and inserted entirely within the depth of said top channel, said front and rear face include a bottom end that is held between said at least one bottom pair of guiding blocks and inserted entirely within the depth of said bottom channel;
a plurality of accessory holders mounted on said at least one vertical panel; and
said one door covers the at least one vertical panel in a closed position.

US Pat. No. 10,477,987

ADVERTISING PANEL AND METHOD FOR MOUNTING TO A SURFACE

K-International, Inc., W...

1. An advertising panel for mounting on a surface, comprising:a panel body having a first end and a second end, the panel body including a front panel configured for holding advertising material or other display, the panel body defining a channel;
a first end cap fastened to the first end of the panel body, the first end cap having at least one arm including a grasping portion;
a suction cup having a stem configured to fit the grasping portion of the at least one arm, the suction cup including a release tab; and
the end cap being fastened on the first end of the panel body with the at least one arm extending into the channel and the suction cup stem fit to the grasping portion of the at least one arm, the release tab extending from the panel body when the panel body is secured to a surface using the suction cup.

US Pat. No. 10,477,979

POCKETED SPRING ASSEMBLY

1. A bedding or seating product comprising:a pocketed spring assembly having a uniform height and comprising a plurality of parallel strings of springs including exterior strings and interior strings, each of said strings being joined to at least one adjacent string and being approximately the same height, each of said strings comprising first and second opposed plies of fabric and a plurality of pockets formed along a length of said string by transverse seams joining said first and second plies, and at least one spring positioned in each of said pockets;
each of said springs having upper and lower end turns and a plurality of central convolutions between said end turns, at least one of the central convolutions having a barrel diameter greater than the diameters of the other convolutions of the spring;
the pocketed spring assembly having a perimeter section surrounding an interior section, the perimeter section comprising two side sections and two end sections, each side of the perimeter section being firmer than the core section due to the out-of-pocket characteristics of the springs within the sections, each of the springs of the interior section having an out-of-pocket barrel diameter greater than the out-of-pocket barrel diameter of the springs of the end and side sections and each of the springs of the interior section having a shorter out-of-pocket height than the springs of the end and side sections,
wherein each of said pockets of each of the exterior strings contains an edge spring, each of the edge springs having a first out-of-pocket barrel diameter and a first out-of-pocket height;
each of the interior strings having two different springs, core and edge springs along its length and comprising outer pockets and inner pockets between the outer pockets, each of the inner pockets containing a core spring and each of the outer pockets containing an edge spring, each of the core springs having a second out-of-pocket barrel diameter and a second out-of-pocket height, the first out-of-pocket barrel diameter of the edge springs being less than the second out-of-pocket barrel diameter of the core springs and the first out-of-pocket height of the edge springs being greater than the second out-of-pocket height of the core springs, such that due to the core and edge springs having approximately the same in-pocket height, each of the interior strings having pocketed springs of different firmness, providing the pocketed spring assembly with four sides of edge support, the pocketed edge springs surrounding the pocketed core springs;
cushioning materials; and
a covering encasing said pocketed spring assembly and cushioning materials.

US Pat. No. 10,477,976

SUSPENDED BACK PILLOW FOR MAINTAINING A SIDE SLEEPING POSITION

Family Concepts II, LLC, ...

1. A method for maintaining a side-sleeping orientation for an individual alternately on either a left or right side which comprises the steps of:a) attaching a back pillow at the back of the individual in a suspended configuration with respect to and substantially aligned with the individual's spine, said suspended configuration including a hinge attachment function which enables the pillow to fall into near contact at either a laterally offset left or right, back side of the individual when the individual is lying on their respective left or right side;
b) positioning at least one front pillow at a knee and/or front trunk location for establishing at least three different points of contact reference to the individual in accordance with a positional orientation sleep aspect (POSA) for providing a three-dimensional frame of reference for the individual during sleep;
c) initiating rotation of the individual's back toward the suspended pillow and toward a supine position;
d) impeding displacement of the pillow along the bed surface and away from the individual's back during rotation;
(e) partially capturing the back pillow between the bed and lateral back side of the individual while maintaining contact at the front side of the individual with at least one front pillow, thereby blocking full rotation to the supine position; and;
(f) regularly repeating this method during successive nights of sleep for a sufficient period of time to establish a subconscious illusory expectation by the individual that the back pillow will be in a position to block supine sleep positions with the actual use of the at least one front pillow.

US Pat. No. 10,477,972

ASSEMBLING STRUCTURE OF SUPPORT DEVICE OF A CHAIR

DONGGUAN KENTEC OFFICE SE...

1. A support device of a chair, comprising:an outer frame, having a surrounding trough;
fasteners, disposed in the surrounding trough, and each having an engaging portion;
an inner frame, having a front and a rear;
a supporting body, made of a flexible material, and having a loading side and a connecting side; and
pressing strips, surroundingly attached on a periphery of the connecting side, and an interval being kept between two adjacent pressing strips to provide flexibility;
wherein the supporting body covers the front of the inner frame, the pressing strips are fastened onto the rear of the inner frame, the inner frame with the supporting body is embedded into the surrounding trough to engage with the engaging portions of the fasteners, the inner frame is formed with installing holes corresponding to the engaging portions of the fasteners, an inner wall of each installing hole is provided with a protrudent step portion and a inserting hole formed in the step portion, the engaging portion is composed of elastic arms arranged in an umbrella shape, an outer diameter of the engaging portion is greater than an inner diameter of the inserting hole, so that when the engaging portion has passed the inserting hole, and the elastic arms restore to engage with the step portion.

US Pat. No. 10,477,971

SOFA SEAT CUSHION CORE

1. A sofa seat cushion, comprising:a cushion core comprising a plurality of pocketed springs enclosed within an upholstery foam envelope and arranged in a spring layer;
at least one memory foam layer positioned above the upholstery foam envelope, at least one polyethylene terephthalate layer positioned above the at least one memory foam layer;
an upholstery-grade polyurethane foam layer positioned below the upholstery foam envelope;
and a polyethylene terephthalate layer directly below the upholstery-grade polyurethane foam layer;
an upper and lower friction barrier positioned above and below the memory foam layer; and
an exterior upholstery surrounding the cushion core.

US Pat. No. 10,477,969

JOINT AND FURNITURE WITH JOINT

Ekornes ASA, Ikornnes (N...

1. A balance joint suitable for attaching between a seat arrangement and a chair leg arrangement, the balance joint comprising:first and second mountings together forming a hollow space; and
at least one hinge pin, wherein the first and second mountings are rotatably mounted to each other by the at least one hinge pin, wherein the mountings include an attachment plate and side walls so that the side walls of the first mounting can be arranged outside the side walls of the second mounting, and wherein one of the mountings includes with two additional side walls, so that the hollow space between the mountings is completely delimited by side walls; and
at least one elastic packing arranged in said hollow space and arranged between the mountings so that expansion of the elastic packing is limited by the mounting in all directions.

US Pat. No. 10,477,967

FURNITURE LEG SOCK

1. A furniture leg protective sock to prevent scraping of a floor by furniture having a furniture leg, the furniture leg having a bottom surface for engaging the floor and a side surface substantially orthogonal to the bottom surface, the sock comprising:expandable non-friction material; and
friction material;
said expandable non-friction material allowing the bottom surface of the furniture leg to slide across the floor;
said expandable non-friction material including,
a top portion having an interior surface, an exterior surface and an opening to slip the sock onto the furniture leg,
a closed bottom portion having an interior surface and an exterior surface, said closed bottom portion covering the bottom surface of the furniture leg when said closed bottom portion engages the bottom surface of the furniture leg, and
a middle portion having an interior surface and an exterior surface, said middle portion extending between said opening of said top portion and said closed bottom portion, said middle portion engaging the side surface of the furniture leg;
said middle portion being substantially orthogonal, when said closed bottom portion and said middle portion engage the furniture leg, to said closed bottom portion;
said friction material being formed on a first portion of said interior surface of said middle portion of said expandable non-friction material;
said interior surface of said closed bottom portion of said expandable non-friction material engaging the bottom surface of the furniture leg;
a second portion of said interior surface of said middle bottom portion of said expandable non-friction material and said friction material formed on said first portion of said interior surface of said middle portion engaging the side surface of the furniture leg;
said friction material formed on said first portion of said interior surface of said middle portion of said expandable non-friction material minimizing, when the furniture leg is moved across the floor, slippage of the sock parallel to the side surface of the furniture leg by providing friction therebetween;
said second portion of the interior surface of the middle portion of the expandable non-friction material being without any of the friction material thereon.

US Pat. No. 10,477,963

MODULAR CABINET ASSEMBLY

Seville Classics Inc., T...

1. A modular cabinet assembly, comprising:a first sub-cabinet and a second sub-cabinet, each sub-cabinet comprising:
a back board having at least two separate back board pieces that are pivotably connected to each other;
a left side board pivotably connected to one of the at least two back board pieces, the left side board having opposite left side board end surfaces and a plurality of pairs of first hook holes provided on the left side board end surfaces; and
a right side board pivotably connected to another of the at least two back board pieces, the right side board having opposite right side board end surfaces and a plurality of pairs of first hook holes provided on the right side board end surfaces;
at least one shelf board having opposite ends removably connected to the left side board and the right side board of either the first sub-cabinet or the second sub-cabinet, each of the at least one shelf board having a bottom and a second hook hole formed on the bottom thereof;
a first end board connected to either an upper end of the first sub-cabinet or a lower end of the second sub-cabinet; and
a plurality of hooks that are adapted to removably connect the at least one shelf board to opposite ends of the left side board and the right side board, wherein each hook has two pairs of first barbs that are received in a pair of first hook holes on either the right side board end surface or the left side board end surface, and a second barb that extends upwardly and is received in the second hook hole.

US Pat. No. 10,477,962

QUICK ASSEMBLY TABLE

Millwork Expressions, Inc...

1. A table, comprising:a horizontal surface with tubular brace members attached thereto;
two or more supporting trusses, each supporting truss comprising a plurality of tubular metal truss members disposed in a planar configuration, said tubular truss members being joined by welding at their abutting ends, and insertable posts welded perpendicularly to said tubular metal truss members, wherein said insertable posts are adapted for insertion into said tubular brace members.

US Pat. No. 10,477,961

FOLDING TABLE

LEKISPORT AG, Baar (CH)

1. A portable table, comprising:a table top and a frame,
wherein the frame comprises two front legs and two rear legs, as well as two front arms and two rear arms,
wherein the front legs and the rear legs have in each case a first, lower free end which is directed toward a support and a second, upper end,
wherein the front arms and rear arms have in each case a second, upper end which is directed toward the table top, and a first, lower end,
wherein the front legs, by way of their second, upper end which is located opposite the first, lower free end, and the front arms, by way of their first, lower end which is located opposite the second, upper end, are fastened on a first, front connecting element,
wherein the rear legs, by way of their second, upper end which is located opposite the first, lower free end and the rear arms, by way of their first, lower end which is located opposite the second, upper end, are fastened on a second, rear connecting element,
wherein the first, front connecting element is connected to the second, rear connecting element by means of at least one first connecting rod,
wherein a first coupling element, which connects a front, left arm to a first longitudinal rod which is arranged parallel to the at least one first connecting rod, is arranged on the second, upper end of the front, left arm and in that a second coupling element, which connects a rear, left arm to the first longitudinal rod, is arranged on the second end of the rear, left arm, and wherein a third coupling element, which connects a front, right arm to a second longitudinal rod which is arranged parallel to the at least one first connecting rod, is arranged on the second end of the front, right arm,
wherein a fourth coupling element, which connects a rear, right arm to the second longitudinal rod, is arranged on the second end of the rear, right arm,
wherein the table top comprises at least one device by which the table top is releasably fastenable on the frame, and
wherein each of the first to fourth coupling elements is formed in an angled and integral manner and comprises a first sleeve portion for receiving a front end or rear end of one of the two longitudinal rods, and comprises a second sleeve portion which is arranged at an angle to the first sleeve portion and is realized for receiving an upper end of an arm of the frame.

US Pat. No. 10,477,960

RETRACTABLE DESK AND SHELF WITH MAGNETIC WALL ATTACHMENT

Reeve Johnson, Telluride...

1. An adjustable desk comprising:a first bracket having a first rotational elongated member, a first non-rotational elongated member, a first magnet coupled to the first non-rotational elongated vertical member, and a first hinge coupled to an inner end of the first rotational elongated member, an upper end of the first non-rotational elongated vertical member, and a first support member coupled between the first rotational elongated member and the first non-rotational elongated vertical member;
a second bracket having a second rotational elongated member, a second non-rotational elongated vertical member, a second magnet coupled to the second non-rotational elongated vertical member, a second hinge coupled to an inner end of the second rotational elongated member and an upper end of the second non-rotational elongated vertical member, and a second support member coupled between the second rotational elongated member and the second non-rotational elongated vertical member; and
a planar desktop rigidly coupled to the first rotational elongated member and the second rotational elongated member;
wherein the first magnet holds the first non-rotational elongated vertical member against a vertical wall, the second magnet holds the second non-rotational elongated vertical member against the vertical wall, the first support member and the second support member have an extended position which holds the desktop and the first rotational elongated member and the second rotational elongated member in a horizontal position and the first support member and the second support member have a retracted position where the desktop and the first rotational elongated member and the second rotational elongated member in a downward rotated position and a slide force (Fslide)=a magnetic force (Fmagnetic)×a coefficient of friction (CF) of the first magnet and the second magnet against the metal bar supports the weight of the first bracket, the second bracket, and the planar desktop.

US Pat. No. 10,477,959

BRUSH HEAD MANUFACTURING METHODS

KONINKLIJKE PHILIPS N.V.,...

1. A method for manufacturing a brush head, the method comprising the steps of:providing a plurality of polypropylene bristle tuft retention rings having an exterior wall that is polygonal, wherein the exterior wall includes a straight taper;
inserting a respective nylon bristle tuft into each of the bristle tuft retention rings;
applying heat to each bristle tuft proximal end at a temperature sufficient to at least partially melt the bristle tuft proximal end and create a proximal head portion;
positioning a platen portion of a neck of the brush head in relation to the proximal head portions, wherein the positioning of the platen portion of the neck defines a space in relation to the proximal head portions for injection of a thermoplastic elastomer; and
injecting the thermoplastic elastomer into the space to create an elastomeric matrix that at least partially encompasses the platen, the proximal head portions, and the straight tapers of the polypropylene bristle tuft retention rings.

US Pat. No. 10,477,958

MULTI-COMPONENT BRISTLE HAVING COMPONENTS WITH DIFFERENT ORAL CARE ADDITIVES, AND ORAL CARE IMPLEMENT COMPRISING THE SAME

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle;
a head coupled to the handle;
at least one bristle tuft extending from the head, the at least one bristle tuft comprising at least one multi-component bristle comprising a first component and a second component;
the first component comprising a first plastic and a first oral care additive;
the second component comprising a second plastic and a second oral care additive, wherein the first oral care additive is a different material than the second oral care additive.

US Pat. No. 10,477,950

INTEGRATED CARRYING STRAP

1. A carrying loop for a container, the carrying loop comprising:a first elongate web having a distal end and a proximal end;
a second elongate web having a distal end and a proximal end, wherein the proximal end of the second elongate web extends from the proximal end of the first elongate web;
a first attachment portion located near the distal ends of the first and second elongate webs, the first attachment portion couplable to a first location on the container; and
a second attachment portion located near the proximal ends of the first and second elongate webs, the second attachment portion removably couplable to a second location when the carrying loop is in a stowed position,
wherein, in the stowed position, a first section of the first elongate web near the distal end is configured to circumferentially wrap around and continuously abut the container and a second section of the first elongate web near the proximal end is configured to circumferentially overlap and abut the first section, and wherein the second location is on the second elongate web.

US Pat. No. 10,477,945

GEL COSMETIC APPLICATOR

HCT GROUP HOLDINGS LIMITE...

1. A cosmetic applicator comprising:an applicator body formed from a first material encapsulated by a second material, wherein the first material is a gel material, the applicator body defining an application surface for applying cosmetics, wherein the gel material has a hardness of 90 or less on a Shore 000 scale; and
an insert including a first end disposed within the gel material and a second end extending out of the gel material, the second end configured for coupling to a product reservoir.

US Pat. No. 10,477,943

VOLUME CREAM CONTAINER

1. A volume cream vessel, comprising:a cream vessel configured to contain a cosmetic content, the cream vessel having an open upper part;
a rim member mounted on the upper part of the cream vessel;
a pumping device seated on the rim member and configured to upwardly pump the cosmetic content inside the cream vessel;
a pressing member disposed on an upper part of the pumping device, wherein one edge of the pressing member is coupled to the rim member so as to operate the pumping device by a pressing operation; and
a cover member configured to cover an upper part of the pressing member,
wherein the pumping device includes:
a seating member having a cylindrical projection part which is downwardly projected in a cylindrical shape and a through hole which is formed through an eccentric position of a bottom of the cylindrical projection part to lift the cosmetic content in the cream vessel, wherein an outer periphery of the cylindrical projection part is seated on the rim member;
a cylinder which is vertically disposed in the through hole of the seating member;
a pump cap on which an upper surface of the cylinder is seated;
an operating member set which is disposed at a center of the pump cap to upwardly pump the cosmetic content by pressing the pressing member; and
a cosmetics applying member which is disposed at an upper part of the operating member set and protrudes upwardly from one side of the pressing member to apply the cosmetic content which is lifted by a pumping operation of the operating member set.

US Pat. No. 10,477,942

APPLICATOR TIP FOR COSMETIC PRODUCT, ASSOCIATED APPLICATOR AND APPLICATOR ASSEMBLY

ALBEA SERVICES, Gennevil...

1. An applicator tip for cosmetic product, said applicator tip comprising:a fixing part for fixing to a support rod, and
an application part for applying said product,
said application part having at least two opposing rounded applicator faces that are hinged to said fixing part and extend as far as a distal end of the applicator in a main direction of longitudinal extension,
said rounded applicator faces having a radius of curvature of less than 6 mm,
said fixing part comprising a sleeve,
said application part being connected to said sleeve by means of a flexible restriction, such that said application part is rotatable relative to said sleeve about at least two axes of an orthonormal coordinate system,
said restriction being rounded and substantially concave in shape, and when viewed in a plane that is transverse to said main direction, said rounded shape having a radius of curvature of less than 6 mm and wherein said restriction has a circular cross section that is transverse to the main direction, that is substantially circular in shape and the diameter of which is at least equal to 1.5 mm.

US Pat. No. 10,477,940

FOLDER TYPE COSMETIC CONTAINER

CTK COSMETICS CO., LTD., ...

1. A folder type cosmetic container, comprising:a container part having an open front end and configured to store a content;
a housing configured to accommodate the container part;
a pressing-dispensing assembly configured to dispense the content in the container part by pivoting adjacent the front end of the housing and pressing the container part; and
a fixed-quantity dispensing assembly configured to dispense a predetermined amount of the content at the front end of the container part by being moved by pressure of the content pressured and moved by the pressing-dispensing assembly,
wherein the fixed-quantity dispensing assembly includes:
a dispensing guide shaft; and
a dispensing control portion protruding from an end of the dispensing guide shaft to guide the content that is dispensed.

US Pat. No. 10,477,933

SMART LUGGAGE SYSTEM WITH CAMERA INSTALLED IN PULL ROD

LINGDONG TECHNOLOGY (BEIJ...

1. A smart luggage system, comprising:a piece of luggage configured to store items for transport;
a handle coupled to the luggage, wherein the handle includes a pull rod coupled to a connecting rod;
an upper camera disposed in a top portion of the pull rod; and
a control button coupled to the luggage or the handle and configured to stop a people following function of the smart luggage system and start a photo/video taking process of the smart luggage system.

US Pat. No. 10,477,932

PORTABLE SECURE CARRIER ARRANGEMENT

1. A secure carrier arrangement, comprising:a bottomless cylindrical housing having a cylindrical peripheral wall defining a central opening passing through the housing, a first fastening element provided on an inner surface of the peripheral wall, said cylindrical peripheral wall provided at a shoulder disposed perpendicular thereto and extending radially inwardly from said cylindrical peripheral wall, said central opening terminating at the shoulder, such that a receiving cavity is formed by said cylindrical peripheral wall and said shoulder;
a first strap member having a base end and a distal end;
a second strap member having a base end and a distal end;
a storage container including:
a base including a first portion having a first thickness and a second portion having a second thickness smaller than said first thickness such that a step formation is defined between said first portion and said second portion, an article receiving cavity is formed at an interface between said first and second portions having an access portal within said step formation, and
a top portion,
wherein, in use an article to be stored is inserted into said article receiving cavity via said access portal within said step formation, such that a portion of the article extends outwardly from said first portion, and another portion of the article, disposed within said article receiving cavity, is concealed within said cavity by said first portion, and
wherein said storage container is devoid of fastening mechanisms; and
a closure cap having a circular upper wall and a side cylindrical wall affixed to said circular upper wall, said side cylindrical wall having a second fastening element configured to securely interconnect with said first fastening element, said closure cap configured to encase said storage container,
whereby upon placement of the storage container within the receiving cavity and under the closure cap, the second fastening element of the closure cap securely interconnects with said first fastening element of said cylindrical peripheral wall and the storage container is secured within the receiving cavity, and
whereby, upon positioning of said secure carrier arrangement on the body of a user, said base of said storage container due to the bottomless formation of the housing is disposed against the body of the user.

US Pat. No. 10,477,929

MODULAR ACCESSORY APPARATUS

REGAL JEWELRY MANUFACTURE...

1. A modular accessory apparatus, comprising:a body component, having a first end and a second end, the body component having a curvature such that a gap forms between the first end and the second end along the direction of extension of the curvature, and the first end has a connector; and
a housing component for modularly coupling to the connector, wherein the housing component comprises:
a housing body having an opening;
a coupler component disposed in the housing body; and
a gateway block disposed in the opening, and the gateway block has a through-hole corresponding to the coupler component;
wherein the connector passes through the through-hole and engages with the coupler component, and the through-hole of the gateway block limits a displacement movement of the connector to the direction through the through-hole;
wherein the coupler component is formed substantially in the shape of an ohm symbol (), wherein the coupler component has a coupler base, two guidance components respectively connected to the coupler base, and a coupler opening formed between the two guidance components; the coupler opening corresponds to the opening of the housing body and the through-hole of the gateway block.

US Pat. No. 10,477,928

SYSTEM FOR ZIPPERS

1. An apparatus for joining two pieces of material, comprising:a right-hand-side bottom stop including a right-hand-side front face and a right-hand-side inner face, the right-hand-side inner face including a slot configured to receive an insertion pin;
a left-hand-side bottom stop including a left-hand-side front face and a left-hand side inner face positioned as a face closest to and facing the right-hand side inner face, the left-hand side inner face including an insertion pin configured to be inserted into the right-hand-side inner face;
a slider with an outer-face, the slider coupled to a zipper chain in a way that allows the slider to slide toward and away from the right-hand-side bottom stop;
the right-hand-side front face having a portion that extends beyond the outer-face of the slider.

US Pat. No. 10,477,924

WINDING DEVICE

JAPANA CO., LTD., Nagoya...

1. A winding device comprising:a first rotation shaft that rotates and drives a first string winding unit;
a second rotation shaft arranged coaxially with the first rotation shaft to rotate and drive a second string winding unit;
a first gear coupled to the first rotation shaft;
a second gear coupled to the second rotation shaft and located at a position opposing the first gear and spaced apart from the first gear;
a sliding gear member arranged between the first and second gears and including a third gear and a fourth gear respectively engaged with the first gear and the second gear;
a handle including a gear accommodation portion that is tubular and has a closed end, and accommodates the first gear, the second gear, and the sliding gear member;
an inclined groove formed in an inner surface of the gear accommodation portion and extending in the inner surface of the gear accommodation portion from an opening of the gear accommodation portion toward the closed end of the gear accommodation portion;
an engagement projection formed on an outer surface of the sliding gear member, wherein the engagement projection engages the inclined groove and is slidable in the inclined groove; and
a lock member that restricts a slidable range of the engagement projection, which is arranged in the inclined groove, from the opening of the gear accommodation portion and restricts separation of the engagement projection from the inclined groove, wherein
a change in a rotation direction of the handle moves the sliding gear member in an axial direction of the first and second rotation shafts and switches the gear engaged with and rotated and driven by the gear of the sliding gear member between the first gear and the second gear.

US Pat. No. 10,477,923

DETECTOR SYSTEM FOR USE WITH FOOTWEAR

NIKE, Inc., Beaverton, O...

1. An article of footwear comprising:a footwear structure including a footwear upper coupled to a footwear sole;
a motorized lacing engine coupled to the footwear structure;
a processor circuit; and
a body detector system including a body sensor configured to detect a presence of a user body based on a change in an electric field, wherein the change in the electric field is caused at least in part by the user body;
wherein the body sensor is configured to provide a sensor signal that includes information about a presence or absence of the user body; and
wherein the processor circuit is configured to receive the sensor signal and provide instructions to the motorized lacing engine based on information from the sensor signal.

US Pat. No. 10,477,917

ENERGY RETURN ORTHOTIC SYSTEMS

1. A tri-layer orthotic system constructed of a resilient material, the tri-layer orthotic system comprising:a base layer having a distal toe end and a proximal heel end;
a resin;
a mid-layer having a distal toe portion, a mid-portion and a proximal heel portion, said distal toe portion of the mid-layer integrally fused to the distal toe end of the base layer by said resin to form a forefoot portion, said proximal heel portion including an opening cut into the mid-layer proximal heel portion that conforms to a heel of an individual; and
an upper layer having a front upper layer portion, an arch upper layer portion and a heel upper layer portion, said heel upper layer portion integrally fused to the proximal heel portion of the mid-layer by said resin to form an open heel portion, said upper layer including a plurality of segmented digit rays cut into the front upper layer portion, said arch upper layer portion is cut into the upper layer and is configured to be deformed upwardly above said upper layer or downwardly below said upper layer;
wherein the upper layer is suspended over the mid-layer and the heel portion is suspended over the proximal heel end of the base layer, wherein the suspension in combination with the resilient material creates a rear spring section, a mid-spring section and a front spring section.

US Pat. No. 10,477,914

SHOE HAVING A SOLE STRUCTURE AND AN AIR PUMP DEVICE FOR BLOWING AIR INTO A SHOE INTERIOR SPACE

ATMOS AIRWALK AG, Zurich...

1. A shoe comprising a sole structure having a top side facing a shoe interior space, and an air pump device for blowing air into the shoe interior space, wherein the air pump device comprises:a bellows formed in a cavity in a heel area of the sole structure;
an intake channel coupled to the bellows for transporting air to the bellows from an intake opening; and
an air supply device coupled to the bellows for forwarding air from the bellows into the shoe interior space;
wherein the sole structure has, at least in the heel area, a multilayer structure comprising:
at least one cover layer comprising a layer of a bending stiff material arranged over the cavity;
at least one intermediate layer of a compressible material, the intermediate layer containing the cavity; and
at least one outsole layer arranged below the cavity;
wherein the layer of the bending stiff material forms a bending stiff plate that overlaps the cavity;
wherein the cavity extends horizontally over most of the surface of the heel area so that a support strip of the compressible material of the at one intermediate layer remains between the cavity and the outside edges of the sole structure on the sides and at the heel;
wherein the support strip extends vertically over the full height of the cavity and the average width of the support strip is not more than 20% of the maximum width of the heel area measured transversely to the walking direction;
wherein the cavity has an average height of at least 4 mm; and
wherein the compressible material has an average hardness between 30 and 55 Shore-A at least in the area of the support strip.

US Pat. No. 10,477,911

ARTICLE OF FOOTWEAR AND CHARGING SYSTEM

NIKE, Inc., Beaverton, O...

1. An article of footwear, the article of footwear comprising:an upper and a sole structure;
an automated tensioning system that is configured to adjust a tension level of the article of footwear from a first tension level to a second tension level, wherein the first tension level is greater than the second tension level;
a charging assembly, the charging assembly comprising an internal charging device and a housing;
a sensor, the sensor providing information to the automated tensioning system when the charging assembly is connected to an external charging device; and
the automated tensioning system being configured to loosen the article of footwear from the first tension level to the second tension level when the automated tensioning system receives information from the sensor indicating that the charging assembly is connected to the external charging device.

US Pat. No. 10,477,910

FLEXIBLE SOLE AND UPPER FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A midsole for an article of footwear, the midsole comprising:a midsole body comprising a toe portion, a midfoot portion, and a heel portion;
a first surface and a second surface opposite the first surface, the midsole body extending between the first surface and the second surface; and
a plurality of sipes extending from the first surface into the midsole body, the plurality of sipes comprising:
a plurality of arcuate sipes extending longitudinally, wherein the plurality of arcuate sipes comprises a first arcuate sipe having a first length extending from the toe portion to the heel portion, an intermediate arcuate sipe having a second length that is shorter than the first length, and a plurality of shorter arcuate sipes each having a third length that is shorter than the second length, and
a first diagonal sipe and a second diagonal sipe, the first diagonal sipe intersecting the second diagonal sipe,
wherein the first arcuate sipe intersects the first diagonal sipe and the second diagonal sipe at a location in which the first diagonal sipe intersects with the second sipe,
wherein the intermediate arcuate sipe, the plurality of shorter arcuate sipes, and at least a portion of the first arcuate sipe are parallel to a curvature of a lateral edge of the midsole.

US Pat. No. 10,477,906

WINGED CAPE FOR CHILDREN'S PLAY

1. A winged cape for wearing by a person, comprising:a flexible inner web and a flexible outer web, each web sharing a common outline representing a pair of wings, each web mutually fixed at least along their common outline, each web having a top edge and at least one side edge;
at least four parallel arm slots formed through the inner web to define sleeves generally orthogonal to a longitudinal axis of each web, the sleeves mutually coaxially aligned and integrally formed with the inner web;
whereby when worn each arm of the person positioned through one of the arm sleeves between the arm sleeve and the outer web, the longitudinal axes of the webs are parallel with and aligned with the person's torso, the webs forming the winged cape when worn by the person,
wherein each web is further directly mutually sewn together along at least two additional stitches outside of the sleeves defined between arm slots in the inner web.

US Pat. No. 10,477,905

STOWABLE GARMENT SYSTEM WITH QUICK RELEASE MECHANISM

NIKE, Inc., Beaverton, O...

1. A stowable garment system comprising:a belt structure having a pouch positioned on a front aspect of the belt structure, the pouch comprising releasable fasteners positioned on an outer-facing surface of the pouch, the pouch formed by a panel attached to the belt structure and having a top side, a bottom side, a first side, and a second side, wherein a first flap extends from the top side of the panel and has a first hole extending therethrough, a second flap extends from the first side of the panel and has a second hole extending therethrough, a third flap extends from the second side of the panel and has a third hole extending therethrough, and a fourth flap extends from the bottom side of the panel and has a second looped cord segment attached thereto, wherein the first flap, the second flap, the third flap, and the fourth flap of the pouch at least partially overlap each other so that the first hole, the second hole, and the third hole are generally aligned when the pouch is in a closed state, and wherein the second looped cord segment of the fourth flap extends through the first hole, the second hole, and the third hole when the pouch is in the closed state; and
an upper-body garment comprising a front section, a back section, and a bottom margin, wherein a portion of the front section is attached to the pouch, and wherein the back section comprises a first tab having a first looped cord segment and extending from the bottom margin at a first side of the back section and a second tab extending from the bottom margin at a second opposite side of the back section, wherein both the first tab and the second tab comprise a releasable fastener configured to mate with the releasable fasteners positioned on the outer-facing surface of the pouch when the upper-body garment is stowed within the pouch, and wherein the second looped cord segment of the fourth flap receives the first looped cord segment of the first tab when the pouch is in the closed state and the upper-body garment is stowed within the pouch.

US Pat. No. 10,477,902

BREAST SUPPORT GARMENT

LULULEMON ATHLETICA CANAD...

1. A breast support garment comprising:a front panel configured to cover at least a portion of a wearer's chest;
a pair of straps each having a first end connected to the front panel; and
a reinforcing frame comprising
a front reinforcing structure connected to the front panel and defining two breast areas, the front reinforcing structure comprising
a central reinforcing element with two crisscrossing legs configured to extend from a chest region of a first breast to an under-breast region of an opposite breast thus separating the two breast areas,
each of the leg of the central reinforcing element having a top end that is in contact with the first end of the respective strap,
wherein the front reinforcing structure is a single piece with a pre-defined structural property and is configured to support breast tissue directly around a root of each breast.

US Pat. No. 10,477,897

AIR AND/OR AEROSOL HEATER

1. An air and/or aerosol heater for an e-cigarette, the heater comprising:a tube in which air and/or aerosol can be heated; and
a resistor element arranged on an outer surface of the tube or on an inner surface of the tube, wherein the resistor element is fixed on the tube, the resistor element being fixed on the tube with a covering in at least some sections, with a fixing layer or with a casting, in at least some sections, with a fixing layer, at least a portion of the fixing layer defining at least a portion of an outermost layer of the heater, wherein an effective cross section of the resistor element is greater at tube ends than in a middle of the tube.

US Pat. No. 10,477,895

ELECTRONIC CIGARETTE ATOMIZER

O-NET AUTOMATION TECHNOLO...

1. An electronic cigarette atomizer, comprising:an atomizing assembly,
a smoke duct, and
a cigarette holder,wherein the smoke duct comprises a liquid storage cavity for storing tobacco liquid and a flue; the smoke duct is cooperatively mounted respectively with the atomizing assembly and the cigarette holder,wherein the atomizing assembly comprises: a holding frame, comprising an air channel communicated with the flue and end-surface slots for accommodating a heating module; andthe heating module, comprising a ceramic base body and a heating wire wound on the ceramic base body, wherein the heating wire is electrically connected with the holding frame, and the ceramic base body is of a hollow micropore structure and is communicated with the liquid storage cavity;wherein the holding frame comprises an outer holding frame, a middle holding frame and an inner holding frame, the outer holding frame and the inner holding frame are conductive holding frames, and the middle holding frame is an insulating holding frame and nested between the outer holding frame and the inner holding frame for insulating and isolating the outer holding frame and the inner holding frame and sealing the liquid storage cavity; andwherein the end-surface slots of the outer holding frame and the inner holding frame comprise a large end-surface slot and a small end-surface slot respectively, and the large end-surface slot of the outer holding frame and the small end-surface slot of the inner holding frame are disposed on a same side.

US Pat. No. 10,477,892

APPARATUS FOR SECURING TO THE TOP OF A BOTTLE OR CANISTER FOR PROVIDING A SMOKING ASSEMBLY

1. A method for smoking leaves comprising:filling a vessel with an open top with a volume with water or other liquid so that there is a remaining air volume within the vessel;
engaging a smoking apparatus comprising a straw element and a bowl with the open top of the vessel;
inserting a flame-resistant straw into the straw element and into the interior of the vessel;
positioning the straw relative to the straw element to ensure that the top end of the straw may be placed on the lips of a user without the face of the user coming into close contact with the bowl, such that any flame or heated material within the bowl is at a safe distance from the user's face;
placing crushed plant leaves into the bowl for lighting with a fire instigating device; and
smoking the crushed plant leaves by lighting the plant leaves with a fire instigation device, wherein the user places his or her lips on the top end of the straw, wherein the smoke from the burnt leaves travels down in to the open air chamber of the vessel and up through the straw while being cooled by the water or other liquid and the ambient temperature of the vessel, wherein excess debris from the burnt leaves is filtered down into the water portion of the vessel by falling directly through apertures located on the bottom of the smoking apparatus, and wherein cooled and filtered smoke from the burnt leaves is substantially contained within the air volume within the vessel.

US Pat. No. 10,477,887

SMOKING MACHINE

PHILIP MORRIS PRODUCTS S....

1. A modular smoking system, comprising-,a carousel module comprising a substantially annular carousel, a plurality of smoking article ports configured to receive smoking articles, and a plurality of analysis ports,
the substantially annular carousel comprising at least one ring having an inner surface and an outer surface radially spaced from the inner surface, through which a plurality of identically-dimensioned aerosol-flow channels are defined through the substantially annular carousel, and
each aerosol-flow channel of the plurality of aerosol-flow channels extending radially through the at least one ring of the substantially annular carousel between a smoking article port of the plurality of smoking article ports located at the inner surface of the at least one ring and an analysis port of the plurality of analysis ports located at the outer surface of the at least one ring; and
at least one aerosol analysis module, located radially outwards from the outer surface of the at least one ring and configured to couple to the analysis port, configured to analyze an aerosol generated by a smoking article coupled to the smoking article port,
wherein the inner surface of the at least one ring is configured to rotate relative to the outer surface of the at least one ring.

US Pat. No. 10,477,877

COCOA SHELL POWDER AND PROCESS OF MAKING

BARRY CALLEBAUT AG, Zuri...

1. A cocoa shell powder characterized by the following features:(a) a mean particle size of less than 75 ?m;
(b) a final moisture content of ?5 weight %;
(c) a neutral taste or a light cocoa flavor with slight hints of cinnamon and nuts, free from off-flavours;
(d) colour variations covering a range of natural cocoa powder colour up to a colour of black alkalized cocoa powder;
(e) a dietary fiber content of about 55 weight %;
(f) a total microbiological plate count of less than 5000 colony-forming units per gram; and
(g) a bulk density between 0.35 kg/L and 0.52 kg/L.

US Pat. No. 10,477,874

TIDAL ROTATING OYSTER SHAPER AND CLEANER APPARATUS AND METHOD OF USE

1. A tidal rotating oyster shaper and cleaning apparatus configured to rotate by a source of passive energy, said apparatus comprising:an outer frame;
a containment cage supported by the outer frame, said containment cage having two lateral ends;
at least one container configured to hold oysters, said at least one container located and maintained within the containment cage;
a circular end member mounted on each lateral end of the containment cage, said end members each having outwardly extending teeth which circumscribe the end members;
at least one passive energy capturing pawl configured to contact and engage the teeth which circumscribe the end members on the lateral ends of the containment cage;
whereby upon the introduction of a source of passive energy to the apparatus, the pawl is caused to rotate in a first direction, thereby rotating the end members, the containment cage, and said at least one container within the containment cage.

US Pat. No. 10,477,868

ICING MACHINE AND ICING METHOD

Axis Automation, Hartlan...

1. A machine for simultaneously coating a plurality of items with a coating, each item having a first side and a second side, wherein the plurality of items are placed on the machine in rows which are substantially straight and substantially perpendicular to the direction of travel of the plurality of items through the machine, the machine comprising:a first belt including openings through which the coating can flow;
a first conveyor having a first end and a second end, which moveably supports the first belt such that a top portion of the belt moves in a coating direction, the top portion transitions to a bottom portion of the belt at the second end, the top portion supporting and conveying a plurality of rows of the plurality of items between the first and second ends in the coating direction wherein the plurality of items are supported on the first sides;
a first variable speed drive coupled to the first conveyor to move the top portion in the coating direction;
a pan located between the top and bottom portions of the first belt;
a variable-flow rate icing pump configured to pump the coating into the pan and through the openings to coat the first side of the plurality of items with the coating as the plurality of items move above the pan;
a second belt;
a second conveyor which moveably supports the second belt such that a top portion of the second belt moves in the coating direction;
a second variable speed drive coupled to the second conveyor to move the top portion of the second belt in the coating direction;
a sensor which generates a signal in response to the passing of the plurality of rows of the plurality of items;
a structure which supports the second conveyor relative to the first conveyor such that the coated items drop from the first belt onto the top portion of the second belt such that the coated items are resting upon the second sides after being dropped onto the second belt, the structure further supporting the sensor relative to the top portion of the first belt proximate to the second end;
a controller coupled to the variable speed drives and the sensor, the controller configured to control the first variable speed drive to move the top portion of the first belt at an average speed, and control the second variable speed drive to vary the speed of the second belt in response to the signal generated by the sensor, such that the second belt moves at a drop speed which is below the average speed of the first belt when the coated items are dropped onto the second belt.

US Pat. No. 10,477,841

METHOD AND DEVICE SUITABLE FOR INCUBATING AVIAN EGGS

1. A method for incubating avian eggs, comprising:a. introducing avian eggs into an incubation chamber having an oxygen-containing atmosphere;
b. subsequent to ‘a’, incubating said eggs in said incubation chamber for a period of time that is not less than 25% of the natural incubation period of said eggs;
c. during said period of time of the incubating, changing an orientation of said eggs at a frequency of not less than once every two days; and
d. during said period of time of said incubating, varying a temperature of said atmosphere in said incubation chamber at a frequency of not less than five times a day, the varying comprising:
increasing the temperature of the atmosphere from a first temperature to a second temperature, the difference between the first temperature and the second temperature being not less than 1.0° C.; and subsequently
reducing the temperature from the second temperature to a third temperature, the difference between the second temperature and the third temperature being not less than 1.0° C.wherein the rate of said increasing the temperature of the atmosphere is not greater than 0.9° C./5 minutes;wherein said reducing of said second temperature to said third temperature commences after a period of at least one minute subsequent to attaining said second temperature; andthe rate of said reducing the temperature of the atmosphere is not greater than 0.9° C./5 minutes.

US Pat. No. 10,477,836

DEVICE FOR STABILIZING A TAIL AND PREVENTING AN ANIMAL FROM LICKING OR BITING ITS TAIL

1. A device for stabilizing an animal's tail and preventing the animal from licking and biting the tail, the device comprising:a collar designed to encircle the animal's neck;
a belly strap attached to the collar and designed to be positioned along an underside of the animal's stomach;
a spine strap attached to the collar and designed to be positioned along the animal's spine;
a chest strap attached to both the belly strap and the spine strap, the chest strap sized to encircle the animal's ribcage;
a waist strap attached to both the belly strap and the spine strap, the waist strap sized to encircle the animal proximate to the animal's waist; and
a rear pad with a tail sleeve extending outwardly therefrom, the tail sleeve sized to accommodate the animal's tail,
wherein the rear pad is attached to the spine strap and the waist strap.

US Pat. No. 10,477,831

SELF-DRYING LITTER BOX

1. A self-drying litter box comprising:a tray-superposition arrangement having a lower tray and an upper tray; the upper tray being removably mounted onto the lower tray in spaced relationship so as to define an empty volume therebetween;
the upper tray including a bottom defining a first surface capable of receiving first litter material and waste material thereon; the bottom of the upper tray being provided with apertures for allowing air circulating through the bottom of the upper tray, to dry the first litter and waste materials thereon; the upper tray further comprising a peripheral wall extending upwardly from the bottom, and a connecting skirt extending inwardly with respect to the peripheral wall of the upper tray and downwardly with respect to the bottom of the upper tray, the connecting skirt extending continuously adjacent to a periphery of the upper tray;
the lower tray comprising a bottom defining a second surface and a peripheral wall extending upwardly from the bottom, the upper tray abutting against an upper edge of the peripheral wall of the lower tray with the bottom of the upper tray extending from a junction of the peripheral walls of the upper and lower trays and the connecting skirt extending inwardly from the peripheral wall of the lower tray, into the empty volume and towards the bottom of the lower tray;
the bottom of the lower tray being capable of receiving a portion of the first litter material and waste materials that falls from the upper tray through the apertures defined in the bottom of the upper tray;
the peripheral wall of the lower tray being provided with at least one ventilation opening for allowing at least one of a) air circulating from the empty volume to outside of the tray-superposition arrangement, and b) air circulating from the outside of the tray-superposition arrangement to the empty volume; and
whereby, in operation, the litter and waste materials in the upper and lower trays are dried by air circulating through the bottom of the upper tray and through the at least one ventilation opening.

US Pat. No. 10,477,786

TWO-STAGE AEROPONIC GROWING SYSTEM AND METHOD

Eric John Wilson, North ...

1. A two-stage aeroponic growing system, the system comprising:at least one cylindrical container comprising a generally cylindrical sidewall that forms a generally cylindrical cavity, the cylindrical sidewall defined by a plurality of spaced-apart, elongated side apertures, a closed end defined by a plurality of spaced-apart end apertures, and an open end terminating at a circumferential edge, whereby a rim extending around the circumferential edge of the at least one cylindrical container;
a cylindrical lid defined by a first face, a second face, and a plurality of lid apertures, the cylindrical lid configured to engage the circumferential edge of the at least one cylindrical container, the cylindrical lid further configured to regulate access to the cylindrical cavity of the at least one cylindrical container;
a sloped container comprising a tray that forms at least one drain hole, the tray surrounded by a first wall, a pair of lateral walls and a generally sloped second wall, the walls having an upper free edge, the tray and the walls forming a cavity, further the sloped container comprising at least one fluid supply hole;
a curved lid having a sloped surface and a circumferential edge configured to mount on to the upper edge of the walls of the sloped container, the sloped surface of the curved lid comprises a central horizontal plane surface and a plurality of gradually sloped plane surfaces from both sides of the central horizontal plane surface, whereby each of the gradually sloped plane surfaces are at a predetermined gradient from the adjacent plane surface, further each of the plane surfaces comprises a plurality of rows of evenly, spaced-apart holes which are configured to enable holding at least one cylindrical container, whereby the rim engages the curved lid allowing the at least one cylindrical container fixedly coupled to the sloped container at a predetermined angle; and
at least one nozzle attached to the fluid supply hole of the sloped container, wherein the at least one nozzle is configured to controllably spray a fluid in the cavity of the sloped container.

US Pat. No. 10,477,783

ENVIRONMENT CONTROLLED MULTI SPAN STRUCTURED GREEN HOUSES FOR COST EFFECTIVE FOOD PRODUCTION

1. An environmentally controlled greenhouse having a roof, the greenhouse comprising:a capture manifold for capturing a carbon dioxide rich greenhouse air during dark hours and an oxygen rich greenhouse air during sunlight hours;
a compressor for compressing the captured carbon dioxide rich and oxygen rich greenhouse air;
a first tank (T1) and a second tank (T2) for dehumidifying, or for maintaining relatively dry, the compressed carbon dioxide rich and oxygen rich greenhouse air;
a release manifold for releasing into the greenhouse at cultivation level, the dehumidified or relatively dry carbon dioxide rich greenhouse air during the sunlight hours, and the dehumidified or relatively dry oxygen greenhouse air during the dark hours;
a third tank (Ta) for storing and dehumidifying compressed atmospheric air for release into the greenhouse to maintain a balance between carbon dioxide and oxygen;an earth tube heat exchanger comprising a first compartment (Ec) for storing the dehumidified carbon dioxide rich greenhouse air, a second compartment (Eo) for storing the dehumidified oxygen rich greenhouse air, a third compartment (Ecd) for storing the relatively dry carbon dioxide rich greenhouse air, and a fourth compartment (Eod) for storing the relatively dry oxygen rich greenhouse air, wherein, in relatively cold weather geographical locations, the earth tube heat exchanger conditions relatively cooler greenhouse air to relatively warmer greenhouse air and, in relatively hot weather geographical locations, the earth tube heat exchanger conditions relatively warmer greenhouse air to relatively cooler greenhouse air,and wherein the earth tube heat exchanger maintains the greenhouse air temperature at a predetermined temperature set point which is equal to an average thermal constant temperature of the geographical location of the greenhouse; anda carbon dioxide sensor,wherein when the content of carbon dioxide in the greenhouse is higher than a predetermined carbon dioxide content set point due to carbon dioxide released by the plants during the dark hours or due to residual carbon dioxide available after carbon dioxide enrichment events during the sunlight hours, the greenhouse carbon dioxide sensor switches on the capture manifold, the compressor, the first tank (T1), the second tank (T2), the release manifold, the third tank (Ta), and the earth tube heat exchanger, and the capture manifold captures the carbon dioxide rich greenhouse air, the compressor compresses the captured carbon dioxide rich greenhouse air, the compressed carbon dioxide rich greenhouse air is dehumidified in the first and second tanks (T1) and (T2), the carbon dioxide rich dehumidified greenhouse air is stored into the first compartment (Ec) and the release manifold releases into the greenhouse, at a cultivation level, the oxygen rich dehumidified conditioned greenhouse air stored in the second compartment (Eo) for maintaining the greenhouse carbon dioxide content at the predetermined carbon dioxide content set point which is equal to the content of carbon dioxide in the atmosphere, and wherein the greenhouse reduces global warming by preventing the greenhouse carbon dioxide from being released into the atmosphere by capturing, compressing, dehumidifying, storing and utilizing the greenhouse carbon dioxide for enrichment during the sunlight hours for maximizing the yield of plants growing in the greenhouse and for maintaining the greenhouse carbon dioxide content at the predetermined carbon dioxide content set point that is equal to the atmospheric carbon dioxide content.

US Pat. No. 10,477,771

AGRICULTURAL HARVESTER HAVING A HEADER BASED HEAT EXCHANGER

CNH Industrial America LL...

1. An agricultural harvester header for operative attachment to a combine, the header comprising:an agricultural harvester header hydraulic system having a header hydraulic fluid, and
a heat exchanger operatively connected to the agricultural harvester header hydraulic system and configured to transfer heat between the header hydraulic fluid and another hydraulic fluid.

US Pat. No. 10,477,765

ROTATABLE COUPLER FOR A REEL ARM OF A REEL HEADER

CNH Industrial America LL...

1. A reel arm for a header of an agricultural harvester comprising:a rotatable coupler having a central rotational axis, the rotatable coupler having a control shaft extending therethrough parallel to the central rotational axis;
a first linkage assembly that includes:
a first end connected to the control shaft about a first lateral side of the rotatable coupler, and
a second end opposite the first end for connecting to a reel tine bar of a first reel assembly of the header; and
a second linkage assembly that includes:
a first end connected to the control shaft about a second lateral side of the rotatable coupler, and
a second end opposite the first end for connecting to a reel tine bar of a second reel assembly of the header.

US Pat. No. 10,477,763

DUAL CUT HEADER ASSEMBLY

CNH Industrial America LL...

1. A dual cut header assembly comprising;a header;
a chopper suspended from the header;
an actuator system consisting of one or more hydraulic cylinders having a first end connected to the chopper and a second end connected to the header for adapting a distance between the chopper and the header such that the actuator system solely connects the chopper to the header;
at least one sensor for measuring a state of the chopper in the form of a pressure exerted by the chopper on a ground surface, the at least one sensor is a pressure sensor for measuring the pressure exerted by the chopper on the ground surface; and
an actuator steering module connected to the actuator system, the actuator steering module comprises a hydraulic accumulator,
wherein the header is provided to be lifted by an agricultural vehicle to cut crop material from a field at a first height, and the first height is selectable by an operator of the agricultural vehicle,
wherein the chopper is provided to cut the crop material at a second height lower than the first height, and
wherein the actuator steering module is configured to automatically adapt the distance based on the measured state of the chopper for automatically keeping the chopper at its second height.

US Pat. No. 10,477,759

GRASS MOWER

Kubota Corporation, Osak...

1. A grass mower comprising:a drive wheel unit;
a variable speed drive mechanism for driving the drive wheel unit;
a mower unit having a cutter blade;
a cutter blade drive mechanism for rotatably driving the mower unit;
a man-operable vehicle speed controlling tool which is operated in a range from a zero vehicle speed position to a maximal vehicle speed position;
an operation detection section for detecting an operational position of the man-operable vehicle speed controlling tool;
a vehicle speed instruction value calculation section for generating a vehicle speed instruction value including a maximal vehicle speed, based on the operational position of the man-operable vehicle speed controlling tool detected by the operation detection section;
a mode selection section for selecting a control mode from a plurality of control modes;
a control table in which a plurality of control parameters are set, the control parameters being provided for the respective control modes, each of the control parameters including a rotational speed value of the cutter blade and a maximal vehicle speed value corresponding to the rotational speed value;
a vehicle speed control target value calculation section configured to calculate a vehicle speed control target value, based on a vehicle speed instruction value generated by the vehicle speed instruction value calculation section and a selected control parameter corresponding to the control mode selected by the mode selection section;
a traveling control section configured to control the variable speed drive mechanism based on the vehicle speed control target value;
a cutter blade control target value calculation section configured to calculate a rotational speed control target value for the cutter blade, based on the selected control parameter; and
a cutter blade control section configured to control the cutter blade drive mechanism based on the rotational speed control target value.

US Pat. No. 10,477,758

MULTIPLE SEED-TYPE SEED METER

CNH Industrial America LL...

1. A planter for planting multiple types of seed in a single planting pass during row-crop planting of an agricultural field, comprising:a frame;
a bulk storage system supported by the frame and configured for storing multiple types of seeds;
multiple row units supported by the frame, each of the multiple row units including,
an on-row storage system with multiple compartments configured to receive respective ones of the multiple types of seed from the bulk storage system; and
a seed meter for planting the multiple types of seed and including a housing having multiple portions defining multiple seed chambers respectively receiving seeds of multiple types from the multiple compartments of the on-row storage system and multiple seed disk assemblies for selectively delivering individual seeds of the multiple seed types from the multiple seed chambers of the seed meter out of the housing for release onto an agricultural field during row-crop planting of the agricultural field.

US Pat. No. 10,477,757

DUAL-DISK SEED METER FOR MULTI-VARIETY SEED PLANTING

CNH Industrial America LL...

1. dual-disk seed meter for a planter, the dual-disk seed meter comprising:a housing defining a first seed chamber configured to receive a plurality of first seeds of a first seed type and a second seed chamber configured to receive a plurality of second seeds of a second seed type;
a first seed disk rotatable within the housing to convey the first seeds from the first seed chamber;
a second seed disk rotatable within the housing to convey the second seeds from the second seed chamber;
a drive assembly configured to simultaneously rotate the first and second seed disks relative to the housing; and
a seed deflector positioned within the housing and movable relative to at least one the first seed disk or the second seed disk to control which of the first and second seed types is discharged from the housing based on a selected seed type to be delivered by the seed meter.

US Pat. No. 10,477,753

APPARATUSES, METHODS, AND SYSTEMS FOR PROVIDING DOWN FORCE FOR AN AGRICULTURAL IMPLEMENT

Kinze Manufacturing, Inc....

1. An agricultural implement, comprising:a toolbar; and
a row unit comprising a frame and a strut, the strut connected to the toolbar and several fluid components, the fluid components comprising at least a furrow opener;
substantially rigid components connected to the toolbar, the rigid components comprising at least a seed meter for planting seed, a seed tube for passing seed from the seed meter, and a closing wheel;
the strut having a housing generally fixed in position and connected to the seed meter, and a rod movable relative to the housing, the rod connected to the furrow opener;
wherein the strut provides a down force for the fluid components.

US Pat. No. 10,477,752

ROW UNIT FOR AGRICULTURAL IMPLEMENT

Dawn Equipment Company, ...

1. A downforce control system for a planter row unit, comprising:a downforce actuator associated with the planter row unit to urge the row unit downwardly with a controllable force that can be adjusted,
said planter row unit producing a gauge wheel downforce during planting operations,
said downforce actuator disposed to change said gauge wheel downforce when actuated;
a control module for defining a desired gauge wheel downforce;
a valve in fluid communication with said downforce actuator for adjusting the fluid pressure supplied to said actuator, said valve associated with the planter row unit; and
a controller for adjusting the gauge wheel downforce produced by said downforce actuator.
US Pat. No. 10,479,854

CONJUGATE FOR TREATING MALARIA

Stellenbosch University, ...

1. A peptide-polymer conjugate comprising a polymer to which an antiplasmodial peptide is covalently attached, wherein the antiplasmodial peptide is a cyclic decapeptide having an amino acid sequence of cyclo(X10-X1-Leu-D-Phe-Pro-X2-X3-X4-X5-X6) (SEQ ID NO: 1), where:X10 is Val, Ile, or Leu;
X1 is Orn or Lys;
X2 is Val, Leu, Ile, Phe, Trp, or Tyr;
X3 is the D-isomer of Val, Leu, Ile, Phe, Trp, Tyr, or L-isomer of Orn or Lys;
X4 is Asn, Gln or Leu;
X5 is Gln or the D-isomer of Phe; and
X6 is Tyr, Phe, Trp, Pro, or hydroxyproline;
wherein the antiplasmodial peptide is conjugated to the polymer by way of a linkage comprising a beta-thiopropionate or beta-thiopropionamide, which causes the ester or amide linkage to be unstable and to release the antiplasmodial peptide at acidic pH, the linkage being formed by:
modifying the antiplasmodial peptide to comprise an acrylate ester or acrylamide, and
covalently linking the acrylate ester or acrylamide of the modified antiplasmodial peptide to a thiol end-group of a chain end of the polymer via Michael addition, and
wherein the peptide-polymer conjugate can be taken up by erythrocytes and has activity against a malaria parasite.
US Pat. No. 10,479,856

MANUFACTURING METHOD FOR PROPYLENE BLOCK COPOLYMER

TOHO TITANIUM CO., LTD., ...

1. A method for producing a propylene-based block copolymer comprising:a first step of homopolymerizing propylene during which an electron donor compound (IV) is added to form a propylene homopolymer by bringing an olefin polymerization catalyst into contact with propylene;
subsequent to the first step, a second step of copolymerizing propylene and an ?-olefin other than propylene in the presence of the olefin polymerization catalyst and the propylene homopolymer;
the olefin polymerization catalyst comprising a solid catalyst component for olefin polymerization that comprises titanium, magnesium, a halogen, and an internal electron donor compound, an organoaluminum compound represented by a general formula (I), and an external electron donor compound represented by a general formula (II) or an external electron donor compound represented by a general formula (III),
R1pAlQ3-p  (I)
wherein R1 is a hydrocarbyl group having 1 to 6 carbon atoms, p is a real number that satisfies 0 a hydrocarbyloxy group having 1 to 6 carbon atoms, or a halogen atom, provided that
a plurality of Q are either identical to or different from each other when a plurality of Q are present,
R2Si(OR3)3  (II)
wherein R2 is a hydrogen atom, a linear alkyl group having 1 to 20 carbon atoms,
a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, an allyl group,
a linear or branched alkenyl group having 3 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a cycloalkenyl group having 3 to 20 carbon atoms,
an aromatic hydrocarbon group having 6 to 24 carbon atoms, a nitrogen atom-containing hydrocarbon group having 2 to 24 carbon atoms that is terminated by a carbon atom, or an amino group having 2 to 24 carbon atoms, and R3 is a linear alkyl group having 1 to 20 carbon atoms, a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, an allyl group, a linear or branched alkenyl group having 3 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a cycloalkenyl group having 3 to 20 carbon atoms, or an aromatic hydrocarbon group having 6 to 24 carbon atoms, provided that the three R3 are either identical to or different from each other,
(R4R5N)Si(OR6)3  (III)
wherein R4 and R5 are a hydrogen atom, a linear alkyl group having 1 to 20 carbon atoms, a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, an allyl group, a linear or branched alkenyl group having 3 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a cycloalkenyl group having 3 to 20 carbon atoms, an aromatic hydrocarbon group having 6 to 24 carbon atoms, a nitrogen atom-containing hydrocarbon group having 2 to 24 carbon atoms that is terminated by a carbon atom, or an amino group having 2 to 24 carbon atoms, provided that R4 and R5 are either identical to or different from each other, and are optionally bonded to each other to form a ring, and R6 is a linear alkyl group having 1 to 20 carbon atoms,
a branched alkyl group having 3 to 20 carbon atoms, a vinyl group, an allyl group,
a linear or branched alkenyl group having 3 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a cycloalkenyl group having 3 to 20 carbon atoms, or
an aromatic hydrocarbon group having 6 to 24 carbon atoms, provided that the three R6 are either identical to or different from each other, and
wherein the electron donor compound (IV) is an alcohol.
US Pat. No. 10,477,804

PLANTS AND SEEDS OF CORN VARIETY CV644304

Monsanto Technology LLC, ...

1. A plant of corn variety CV644304, wherein representative seeds of corn variety CV644304 have been deposited under ATCC Accession No. PTA-125229.
US Pat. No. 10,482,680

ABLATION THERAPY CONTROL BASED ON MULTI-PARAMETER GRAPHICAL MAPS

CARDIOINSIGHT TECHNOLOGIE...

1. A system comprising:a plurality of sensors configured to measure electrophysiological signals from cardiac tissue associated with a patient;
an ablation catheter configured to deliver an ablative therapy by applying one or more of heating, cooling and high-frequency; and
a computing device coupled to the plurality of sensors, the computing device comprising:
memory storing machine readable instructions and configured to store electroanatomic data; and
at least one processor configured to access the memory and execute the machine readable instructions,
wherein the machine readable instructions are further configured to perform, when executed, a method comprising:
measuring the electrophysiological signals;
storing the electroanatomic data that corresponds to the electrophysiological signals measured by the plurality of sensors;
computing phase data for each of a plurality of points of a geometric surface corresponding to the cardiac tissue based on the electroanatomic data for at least one-time interval;
encoding the phase data to a first color component representing a dimension of a multi-dimensional color model, wherein the multi-dimensional real time model comprises at least two dimensions;
computing magnitude data for each of the plurality of points of the geometric surface corresponding to the cardiac tissue based on the electroanatomic data for at least one-time interval;
encoding the magnitude data to a second color component representing another dimension of the multi-dimensional color model; and
generating the output data corresponding to a multi-parameter graphical map for the geometric surface corresponding to the cardiac tissue of the patient by mapping the phase data to the first color component and the magnitude data to the second color component;
displaying the multi-parameter graphical map for the geometric surface corresponding to the cardiac tissue of the patient;
configuring one or more control parameters for delivering the ablative therapy to the cardiac tissue based on the multi-parameter graphical map;
delivering the ablative therapy to the cardiac tissue according to the one or more control parameters; and
reconfiguring the one or more control parameters intraoperatively during delivery of the ablative therapy based on one or more changes to the output data reflected in the multi-parameter graphical map.
US Pat. No. 10,477,809

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH897928

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH897928, produced by crossing a first plant of variety CV079395 with a second plant of variety CV581707, wherein representative seeds of said varieties CV079395 and CV581707 are deposited under ATCC Accession Nos. PTA-123515 and PTA-125247, respectively.
US Pat. No. 10,479,864

METHOD FOR MANUFACTURING POLYAMIDE-BASED WATER-TREATMENT SEPARATOR HAVING EXCELLENT PERMEATION FLUX CHARACTERISTICS AND WATER-TREATMENT SEPARATOR MANUFACTURED BY SAME

LG CHEM, LTD., Seoul (KR...

1. A method for manufacturing a water treatment separation membrane, the method comprising:forming an aqueous solution layer comprising an amine compound on a porous support; and
bringing an organic solution comprising an acyl halide compound into contact with on the aqueous solution layer to form a polyamide active layer,
wherein the organic solution comprises a non-polar solvent and an amphiphilic solvent having a boiling point of 120° C. or more,
wherein the amphiphilic solvent comprises one or more selected from the group consisting of propylene glycol monomethyl ether acetate, dipropylene glycol monomethyl ether acetate, and 1,3-butanediol diacetate, and
wherein the amphiphilic solvent is comprised in an amount of 0.05 vol % to 10 vol % based on a total volume of the organic solution.
US Pat. No. 10,481,147

CARDIAC STEM CELLS AND METHODS OF IDENTIFYING AND USING THE SAME

VESTION, INC., Miami, FL...

1. A method of treating a heart disease in a subject in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of isolated composition of cardiac progenitor cells, wherein the composition of cardiac progenitor cells comprises cardiac progenitor cells that are phosphorylated retinoblastoma protein positive.
US Pat. No. 10,477,812

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH350667

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH350667, produced by crossing a first plant of variety CV742016 with a second plant of variety CV751695, wherein representative seeds of said varieties CV742016 and CV751695 are deposited under ATCC Accession Nos. PTA-124493 and PTA-124503, respectively.
US Pat. No. 10,481,148

CELL LINE STABLY EXPRESSING NAV1.5 AND METHOD OF SCREENING THERAPEUTIC AGENT USING THE CELL LINE

THE CATHOLIC UNIVERSITY O...

1. A cell line stably expressing voltage-gated sodium channel (Nav1.5), the cell line having accession number KCTC 13095BP, wherein a SCN5A gene consisting of NCBI accession no. NM_198056 encoding Nav1.5 and a puromycin selection marker are inserted into a chromosome of the cell.
US Pat. No. 10,477,814

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH405760

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH405760, produced by crossing a first plant of variety CV758647 with a second plant of variety CV052865, wherein representative seeds of said varieties CV758647 and CV052865 are deposited under ATCC Accession Nos. PTA-123809 and PTA-123058, respectively.
US Pat. No. 10,477,815

SOYBEAN VARIETY 5PLEC93

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PLEC93, representative seed of the variety having been deposited under ATCC Accession Number PTA-126074.
US Pat. No. 10,479,868

POLYMERIC STABILIZING FORMULATIONS

NANO PRECISION MEDICAL, I...

1. A pharmaceutical composition comprising:a therapeutic agent, which therapeutic agent is a peptide, together with a polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups, wherein the polymer is a dendritic polymer or is a crossed-linked polymer, wherein said pharmaceutical composition is disposed within a reservoir of a capsule having a nanoporous membrane with a plurality of pores, the capsule configured for implantation; and
the polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups having molecular dimensions larger than the pore size of the nanoporous membrane, wherein the release of the polymeric stabilizing agent from the reservoir is substantially prevented; and wherein the nanoporous membrane is a diffusion pathway out of the reservoir for the therapeutic agent.
US Pat. No. 10,477,816

SOYBEAN VARIETY 5PZWF45

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PZWF45, representative seed of the variety having been deposited under ATCC Accession Number PTA-126070.
US Pat. No. 10,477,820

SOYBEAN CULTIVAR S170120

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170120, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125459.
US Pat. No. 10,480,130

VOID REDUCING ASPHALT MEMBRANE COMPOSITION, METHOD AND APPARATUS FOR ASPHALT PAVING APPLICATIONS

Heritage Research Group, ...

1. An asphalt composition comprising:an asphalt binder;
an elastomeric polymer;
a wax modifier; and
a filler selected from fumed silica and fumed alumina,
wherein the composition is formulated to include 85 to 97 wt. % of the asphalt binder,
1 to 6 wt. % of the elastomeric polymer,
1 to 5 wt. % of the wax modifier, and
1 to 10 total wt. % of the filler selected from fumed silica and fumed alumina.
US Pat. No. 10,481,158

COMPOSITIONS AND METHODS FOR SCREENING T CELLS WITH ANTIGENS FOR SPECIFIC POPULATIONS

California Institute of T...

1. An antigen complex, comprising:a nanoparticle sorting agent comprising:
a nanoparticle;
a polynucleotide detection tag having at least one coding region, the polynucleotide detection tag being conjugated to the nanoparticle; and
a first polynucleotide hybridization domain conjugated to the polynucleotide detection tag; and
a peptide-loaded streptavidin major histocompatability complex (MHC) tetramer, comprising:
a modified streptavidin protein;
four biotin-modified MHC proteins each independently conjugated to the modified streptavidin protein;
an antigen peptide bound to the biotin-modified MHC proteins; and
a second polynucleotide hybridization domain different from the first polynucleotide hybridization domain and conjugated to the modified streptavidin protein,
the nanoparticle sorting agent being linked to the peptide-loaded streptavidin MHC tetramer by hybridization of the first polynucleotide hybridization domain to the second polynucleotide hybridization domain.
US Pat. No. 10,479,875

PROCESS FOR THE TREATMENT OF A COMPOSITION COMPRISING THERMOPLASTICS

SOLVAY SA, Brussels (BE)...

1. Process for the treatment of a composition comprising thermoplastics, the process comprising the steps ofa) introducing the composition comprising thermoplastics into a reactor under reduction of oxygen content of the atmosphere, wherein the oxygen content is reduced to below 10 vol % of gas phase,
b) heating the composition to a temperature in the range of 150° C. to 450° C. in the presence of a solvent, wherein the solvent has a boiling point of between 50° C. and 150° C. and wherein the amount of solvent is 0.1 kg to 10 kg per kg of thermoplastics, to obtain a drop in viscosity below 104 mPas of at least 50% by weight of the thermoplastics, based on the total content of the thermoplastics,
c) separating solid and/or gaseous fractions of the composition at the surface of the mixture and/or the bottom of the reactor, and
d) recovering liquefied thermoplastics from the reactor,
wherein the process steps a) to c) are conducted in one reactor.
US Pat. No. 10,479,878

ANTI-VIBRATION RUBBER COMPOSITION

SUMITOMO RIKO COMPANY LIM...

1. An anti-vibration rubber composition, comprising:(A) a diene-based rubber;
(B) a halogen-based flame retardant having a melting point of 150° C. or less; and
(C) aluminum hydroxide having an average particle diameter of 0.4 ?m or less,
wherein a blending amount of the halogen-based flame retardant (B) falls within a range of from 15 parts by weight to 60 parts by weight with respect to 100 parts by weight of the diene-based rubber (A), and a blending amount of the aluminum hydroxide (C) falls within a range of from 50 parts by weight to 150 parts by weight with respect to 100 parts by weight of the diene-based rubber (A).
US Pat. No. 10,481,162

PROTEIN SEQUENCING METHOD AND REAGENTS

The Governing Council of ...

1. A method of sequencing a polypeptide comprising:a. affixing the polypeptide to a substrate through a C?-terminal carboxyl group or a side chain functional group of the polypeptide;
b. contacting the polypeptide with a plurality of probes, wherein each probe comprises a fluorescent label and an affinity capture reagent that selectively binds to an N-terminal amino acid or a N-terminal amino acid derivative on the polypeptide;
c. optically detecting the fluorescent label of the probe bound to the polypeptide, thereby identifying the N-terminal amino acid of the polypeptide;
d. cleaving the N-terminal amino acid or N-terminal amino acid derivative of the polypeptide; and
e. repeating steps (b) to (d) to determine a sequence of successive N-terminal amino acids of at least a portion of the polypeptide.
US Pat. No. 10,481,165

ELEVATED CCL19 AFTER COMPLETION OF THERAPY FOR ACUTE LYME DISEASE IDENTIFIES PATIENTS AT RISK FOR DEVELOPMENT OF POST-TREATMENT LYME DISEASE SYNDROME WHO WILL BENEFIT FROM FURTHER ANTIBIOTIC THERAPY

The Johns Hopkins Univers...

1. A method for treating a patient likely to develop post-treatment Lyme disease syndrome (PTLDS) and who is currently undergoing a first course of antibiotic treatment for Lyme disease comprising the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
US Pat. No. 10,481,166

MICROPARTICLE FRACTIONATION

Singapore Health Services...

1. A method for selecting microparticles in a sample, the method comprising selecting microparticles by size; and one or both of:(a) selecting microparticles in the sample which comprise GM1 gangliosides; and
(b) selecting microparticles in the sample which comprise exposed phosphotidylserine.
US Pat. No. 10,481,167

METHODS FOR MEASURING CONCENTRATIONS OF BIOMOLECULES

C2N Diagnostics, Saint L...

1. A method of determining the absolute concentration of an amyloid-beta protein (A?), isoform, variant or digestion product thereof in a subject, comprising:(a) metabolically labeling the endogenous A? protein isoform, variant or digestion product thereof by administering at least one labeled moiety to the subject, wherein the at least one labeled moiety metabolically incorporates into the endogenous A? protein isoform, variant or digestion product thereof;
(b) contacting a biological sample obtained from the subject with a Quantitation Standard (QS) comprising a known concentration of a biomolecule labeled with two labeled moieties such that the labeled QS has a molecular weight that differs from the metabolically labeled endogenous A? protein isoform, variant or digestion product thereof, wherein the QS is an A? peptide, wherein the biological sample comprises a metabolically labeled fraction of the endogenous A? protein isoform, variant or digestion product thereof and an unlabeled fraction of the A? protein, isoform, variant or digestion product thereof;
(c) isolating the metabolically labeled, the unlabeled and the labeled QS forms of A? protein isoform, variant or digestion product thereof from the biological sample using a detergent to increase the labeled A?, unlabeled A? peptides and QS solubility;
(d) maintaining the labeled A?, unlabeled A? peptides and QS in a reduced state to increase said peptides detection;
(e) subjecting the labeled A?, unlabeled A? peptides and QS to mass spectroscopy analysis; and
(f) calculating the absolute concentration of the endogenous, metabolically labeled and unlabeled, A? protein isoform, variant or digestion product thereof using the known concentration of A? protein isoform, variant or digestion product in the labeled QS.
US Pat. No. 10,479,885

THERMOPLASTIC RESIN COMPOSITION AND ARTICLE PRODUCED THEREFROM

Lotte Advanced Materials ...

1. A thermoplastic resin composition comprising:about 10 wt % to about 30 wt % of a first rubber-modified vinyl graft copolymer obtained by grafting a monomer mixture comprising an aromatic vinyl monomer and a vinyl cyanide monomer to a diene rubber polymer;
about 1 wt % to about 15 wt % of a second rubber-modified vinyl graft copolymer obtained by grafting a monomer mixture comprising an aromatic vinyl monomer and a vinyl cyanide monomer to an acrylate rubber polymer;
about 10 wt % to about 40 wt % of a first aromatic vinyl-vinyl cyanide copolymer having a weight average molecular weight of about 250,000 g/mol to about 450,000 g/mol and including about 25 wt % to about 31 wt % of a repeat unit derived from a vinyl cyanide monomer;
about 20 wt % to about 60 wt % of a second aromatic vinyl-vinyl cyanide copolymer having a weight average molecular weight of about 70,000 g/mol to about 150,000 g/mol and including about 33 wt % to about 42 wt % of a repeat unit derived from a vinyl cyanide monomer; and
5 wt % to about 15 wt % of a third aromatic vinyl-vinyl cyanide copolymer having a weight average molecular weight of about 70,000 g/mol to about 150,000 g/mol and including about 25 wt % to about 31 wt % of a repeat unit derived from a vinyl cyanide monomer, each based on 100 wt % of the thermoplastic resin composition,
wherein the thermoplastic resin composition has a fracture strain ratio ?1/?0 of about 65% to about 90%, as measured in accordance with ASTM D543-06 using a 3.2 mm thick specimen, wherein ?1 is fracture strain measured when the specimen not exposed to a chemical reagent is subjected to tensile testing and ?0 is fracture strain measured when the specimen exposed to a chemical reagent is subjected to tensile testing, wherein tensile testing is conducted at a tensile rate of 5 mm/min in accordance with ASTM D638.
US Pat. No. 10,479,889

THERMOPLASTIC RESIN COMPOSITION, MOLDED ARTICLE MADE THEREFROM, AND METHOD OF PREPARING THE COMPOSITION

SAMSUNG ELECTRONICS CO., ...

1. A thermoplastic resin composition comprising:a polylactic acid;
a thermoplastic polymer having a lower glass transition temperature than the polylactic acid;
an inorganic nucleating agent; and
at least two reactive plasticizers comprising a modified vegetable oil,
wherein the thermoplastic resin composition comprises about 70% or more of the polylactic acid based on the total weight of the thermoplastic resin composition,
wherein the thermoplastic polymer comprises an ethylene vinyl acetate copolymer, which comprises about 60 wt % to about 75 wt % of an ethylene-based structural unit and about 25 wt % to about 40 wt % of a vinyl-acetate based structural unit.
US Pat. No. 10,479,890

OXYGEN SCAVENGING POLYESTER COMPOSITIONS FOR CONTAINERS

APG Polytech, LLC, Wilmi...

1. An oxygen scavenging composition for containers comprising:at least one polyester component,
a transition metal catalyst,
an oxygen scavenger, and
a vegetable oil comprising at least one molecule having a double allylic structure,wherein the at least one polyester component comprises at least one acid unit and at least one diol unit, the concentration of the double allylic structures of the vegetable oil in the composition is greater than 5.0 meq/kg of all of the polyester components, the oxygen scavenger is present in the composition in a traditionally inert amount, and the vegetable oil is present in the composition at a level greater than 0.3% by weight relative to the total weight of the polyester components, the transition metal catalyst and the vegetable oil.
US Pat. No. 10,479,133

MOLDING FILM AND MOLDING TRANSFER FOIL USING SAME

Toray Industries, Inc., ...

1. A molding film comprising mainly a cyclic olefin-based resin, whereinwhen an X surface represents one surface of the film and a Y surface represents another surface of the film, the X surface and the Y surface both have a surface glossiness of 50% or less, and
a ratio between thermal shrinkage in a transverse direction and thermal shrinkage in a machine direction at 80° C. satisfies ?2< the thermal shrinkage in the transverse direction/the thermal shrinkage in the machine direction
US Pat. No. 10,479,903

UV-CURABLE INKJET INK COMPOSITION

SHOWA ALUMINUM CAN CORPOR...

1. A UV-curable inkjet ink composition that contains a monofunctional monomer (A), a polyfunctional monomer (B), a photopolymerization initiator (C) and a colorant (D) and is cured by irradiation with ultraviolet light, whereina hydroxyl value of the UV-curable inkjet ink composition is in a range of not less than 1 mgKOH/g and not more than 100 mgKOH/g, and
the UV-curable inkjet ink composition forms, by inkjet printing, an ink layer provided between a curved outer peripheral surface of a can base made of a cylindrical metallic material and a covering layer made of an aqueous coating material.
US Pat. No. 10,479,906

USE OF FUNGAL PIGMENTS FROM WOOD-STAINING FUNGI AS COLORANTS IN WOOD FINISHES AND PAINTS

Oregon State University, ...

1. A composition comprising a fungal pigment suspended or solvated in an oil carrier, wherein the fungal pigment is an extracellular pigment from a fungi selected from the Chlorociboria genus, the Scytalidium genus, or any mixture thereof, and wherein the composition does not include an organic solvent.
US Pat. No. 10,482,993

ANALYZING COPY NUMBER VARIATION IN THE DETECTION OF CANCER

Verinata Health, Inc., S...

1. A method, implemented using a computer system comprising one or more processors and system memory, for identifying the presence of a cancer and/or an increased risk of a cancer in a mammal, said method comprising:(a) providing, to the computer system, at least 10,000 sequence reads of nucleic acids in a test sample from said mammal, wherein said test sample comprises both nucleic acids from cancerous or precancerous cells and nucleic acids from constitutive cells, wherein the sequence reads are provided in an electronic format;
(b) aligning, by the one or more processors, the at least 10,000 sequence reads to one or more reference sequences using a computing apparatus and thereby providing sequence tags corresponding to the sequence reads;
(c) identifying, by the one or more processors, a number of sequence tags from the nucleic acids for one or more sequences of interest amplifications of which or deletions of which are known to be associated with cancers, wherein said sequences of interest are selected from chromosomes 1-22, X, and Y and segments thereof and identifying, by the one or more processors, a number of sequence tags for at least one normalizing sequence for each of the one or more sequences of interest;
(d) calculating, by the one or more processors and using said number of sequence tags identified for each of said one or more sequences of interest and said number of sequence tags identified for each said normalizing sequence, a single sequence dose for each of said one or more sequences of interest,
wherein the at least one normalizing sequence is a sequence that yields sequence doses for the sequence of interest having: (a) the smallest variability among unaffected samples, (b) the greatest differentiability between affected and unaffected samples, (c) the smallest variability and the greatest differentiability, or (d) an optimal combination of small variability and large differentiability;
(e) evaluating said single sequence dose for each of said one or more sequences of interest, and thereby detecting aneuploidies or copy number variations in said sample; and
(f) determining the presence of a cancer and/or an increased risk of a cancer based on the detected aneuploidies or copy number variations.
US Pat. No. 10,478,638

RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF

Korea University Research...

1. A recombinant self-assembled protein, comprising a target-oriented peptide fused to a self-assembled protein, wherein the target-oriented peptide is a cancer-targeting peptide ligand.
US Pat. No. 10,478,385

DENTAL ADHESIVE MATERIAL KIT

KURARAY NORITAKE DENTAL I...

1. A dental adhesive material kit comprising:a dental aqueous adhesive composition (A); and
a dental curable composition (B),
wherein
the dental aqueous adhesive composition (A) comprises a (meth)acrylic polymerizable monomer (a) comprising an acid group, a vanadium compound (b), water (c), a (meth)acrylic polymerizable monomer (d) comprising an amino group, and a polymerization inhibitor (i),
the content of the polymerization inhibitor (i) is 25 to 1000 parts by weight per 100 parts by weight of the vanadium compound (b), and
the dental curable composition (B) comprises a (meth)acrylic polymerizable monomer (e) comprising no acid group, a hydroperoxide (f), a photopolymerization initiator (g), and a filler (h), does not comprise a thiourea compound, and does not comprise borate compounds.
US Pat. No. 10,478,386

TWO-PART COSMETIC COMPOSITION FOR CHANGING COLOR OF KERATINIC FIBERS

1. A two-part cosmetic composition for changing color of keratinic fibers, comprising,(a) a gel-like part having a pH of from about 8 to about 12 and comprising,
optionally an oxidative dye precursor, and
a thickener selected from the group of xanthan gum, anionic amphiphilic polymer, and combination thereof, and
(b) an oxidizing part having a pH of from about 1 to about 5 comprising,
an oxidizing agent, and
a thickener comprising one or more anionic amphiphilic polymers;
wherein the two-part cosmetic composition has a viscosity of from about 1000 to about 200000 mPa·s measured using a Brookfield rotating spindle viscometer Model RVT at about 4 rpm and from about 20 to about 25° C.
US Pat. No. 10,483,519

BATTERY PACK AND BATTERY PACK MANUFACTURING METHOD

Envision AESC Japan Ltd.,...

1. A battery pack comprising:a cell group obtained by stacking a plurality of unit cells in a thickness direction, the unit cells each including a cell body having a power generation element and a flat shape, and an electrode tab protruding out from the cell body, and the electrode tabs having distal end portions bent in a stacking direction of the unit cells; and
a flat plate shape bus bar connecting the distal end portions of the electrode tabs of the unit cells while facing the distal end portions, and electrically connecting the electrode tabs of at least two of the unit cells with each other, wherein:
each of the distal end portions of the electrode tabs of at least two of the unit cells and a surface of the bus bar that faces the unit cells are in contact and welded to each other,
the distal end portions of the electrode tabs that are electrically connected by the bus bar are bent in a same direction,
the cell group comprises spacers disposed between the electrode tabs of the unit cells that are stacked, the spacers including supporting portions that abut the electrode tabs from an opposite side of the bus bar to support the distal end portions of the electrode tabs, and
each of the spacers are attached to a respective one of the unit cells.
US Pat. No. 10,478,392

PEPTIDE AND COSMETIC COMPOSITION COMPRISING SAME FOR PREVENTING SKIN AGING OR SKIN WRINKLE FORMATION

College of Medicine Pocho...

1. A peptide having an activity of facilitating bindings between keratinocytes and increasing expression of junction proteins, consisting of the sequence of SEQ ID NO: 2.
US Pat. No. 10,479,931

POLYMER MOLDING COMPOSITION, WAVELENGTH CONVERTER, BACKLIGHT UNIT, AND LIQUID CRYSTAL DISPLAY DEVICE

FUJIFILM Corporation, To...

1. A composition comprising at least:quantum dots having an emission peak wavelength in a visible light region; and
quantum dots having an emission peak wavelength in an ultraviolet region or in a near-ultraviolet region.
US Pat. No. 10,478,395

PAMOATE SALTS AND METHODS OF USE

1. A pharmaceutical composition comprising a pamoate salt of rivastigmine and a pharmaceutically acceptable carrier.
US Pat. No. 10,478,396

THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE

Rani Therapeutics, LLC, ...

1. A therapeutic preparation comprising parathyroid hormone (PTH), the preparation shaped as a solid tissue penetrating member and configured to penetrate and be inserted into an intestinal wall after oral ingestion, wherein upon insertion, the preparation releases PTH into the blood stream from the intestinal wall by degradation of the tissue penetrating member,wherein the tissue penetrating member has sufficient stiffness to be advanced completely into the intestinal wall by the application of a force to the tissue penetrating member,
wherein a dose of PTH in the preparation is in a range from about 10 to 30 ?g,
wherein the preparation is adapted to be orally delivered in a swallowable capsule, and
wherein the preparation is adapted to be operably coupled to delivery means having a first configuration and a second configuration, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration.
US Pat. No. 10,483,529

COMPOSITE POWDER FOR USE IN AN ANODE OF A LITHIUM ION BATTERY, METHOD OF PREPARING SUCH A COMPOSITE POWDER AND METHOD FOR ANALYSING SUCH A COMPOSITE POWDER

UMICORE, Brussels (BE) S...

1. A composite powder for use in an anode of a lithium ion battery, wherein particles of the composite powder comprise silicon-based domains in a matrix, and wherein the matrix comprises carbon or a precursor material that can be converted into carbon by thermal treatment, and wherein the individual silicon-based domains are either:free silicon-based domains that are not or not completely embedded in the matrix, or
fully embedded silicon-based domains that are completely surrounded by the matrix,wherein the percentage of free silicon-based domains is lower than or equal to 4 weight % of the total amount of Si in metallic or oxidized state in the composite powder, andwherein the silicon-based domains have a weight based size distribution with a d50 of 200 nm or less and a d90 of 1000 nm or less, and wherein the composite powder also comprises graphite, wherein the graphite is not embedded in the matrix.
US Pat. No. 10,478,401

METHODS FOR ENCAPSULATION AND MICROCAPSULES PRODUCED THEREBY

Proteon Pharmaceuticals S...

1. A method for encapsulating a material comprising the steps of:(a) providing an aqueous solution or suspension of the material that is to be encapsulated,
(b) warming the aqueous solution or suspension of material to be encapsulated to a temperature range of from 38° C. to 40° C.,
(c) adding a first biocompatible polymer comprising carboxylic groups for coordination to Zn2+ ions into the warmed aqueous solution or suspension of step (b) comprising the material to be encapsulated,
(d) de-aerating the solution or suspension obtained in step (c),
(e) emulsifying the solution or suspension obtained in (d) in a biocompatible oil comprising a surfactant to create microdroplets of the first biocompatible polymer and the material that is to be encapsulated,
(f) forming microcapsules by dropwise addition of an aqueous solution comprising Zn2+ ions and a second biocompatible polymer comprising a moiety for ionically binding the first biocompatible polymer to the emulsion obtained in (e), whereby the Zn2+ ions bind and cross-link the carboxylic groups of the first biocompatible polymer and the first biocompatible polymer ionically binds and cross-links the second biocompatible polymer to encapsulate the material to be encapsulated.
US Pat. No. 10,483,017

FLAME RETARDANT RESIN COMPOSITION, CABLE USING SAME AND OPTICAL FIBER CABLE

Fujikura Ltd., Tokyo (JP...

1. A flame retardant resin composition consisting essentially of:a base resin comprising 18 to 85% by mass of a high density polyethylene, 9 to 69% by mass of a low density polyethylene, and 3 to 25% by mass of a maleic anhydride modified ethylene-? olefin copolymer, and
25 parts by mass to 110 parts by mass of calcium carbonate particles, more than 1 part by mass to 10 parts by mass of a silicone-based compound, and 2 parts by mass to 20 parts by mass of a fatty acid-containing compound, each on the basis of 100 parts by mass of the base resin.
US Pat. No. 10,478,404

MATERIALS, METHODS AND DEVICES FOR ALTERING CELL REACTIVITY

Arizona Board of Regents ...

1. An ex vivo or in vivo method of treating human cells to modulate their reactivity to exogenous physical forces comprising administering to human cells subjected to exogenous physical forces, a composition comprising an effective amount of one or more agents selected from the group consisting of:(i) a lipid or lipid related compound, hormone, carbachol, atropine, inositol, DMSO, lidocaine, procaine, sex steroids, phenytoin, perylene, 9-(dicyanovinyl) julodinine, 1,6-diphenyl-1,3,5-hexatiene (DPH), TMA-DPH, DPH-PA, cis and trans-parinaric acid, wherein the hormone is selected from the group consisting of cortisol, estradiol, progesterone, medroxyprogesterone, insulin, glucagon, thyroid hormone, and aldosterone;
(ii) sulindac sulfide, phenolic antioxidants, caffeic acid phenethyl ester (CAPE) FAK signaling and modulating agents, resveratrol, Rho kinase inhibitors, Y-27632, inhibitors or modulators of talin, paxilin, and viculin and submembrane mechnotransductive proteins;
(iii) cytochlasins, concanavalin, vincristine, vinblastine, oryzalin, trifluralin, taxol, and taxetere;
(iv) colchicine, colcemid, 9 bromonscapine (EM011), docetaxel, noscapinoids, and tau; or
(v) hypo or hypertonic solutions, saline, lactated ringers, dextrose, sucrose, and mannitol, aqueporin receptors modulating agents, Hg Cl2, G-protein modulating agents, tolvaptan, convivaptan, and vaptans
wherein the exogenous physical force provides a shear stress greater than 50 dynes/cm2, wherein the method further comprising using a ventricular assist device (VAD) to pump blood in a patient's body, wherein the exogenous physical force is a force provided by the VAD.
US Pat. No. 10,481,484

REFLECTIVE MASK BLANK, REFLECTIVE MASK, METHOD FOR MANUFACTURING REFLECTIVE MASK BLANK, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

HOYA CORPORATION, Tokyo ...

1. A reflective mask blank comprising:a substrate, and
a multilayer reflective film, a protective film, and a phase-shift film for shifting a phase of EUV light, which are formed in said order on the substrate,
wherein the protective film is made of a material containing ruthenium as a main component, and
wherein an anti-diffusion layer which contains ruthenium and oxygen is formed on a surface of the protective film, or as a part of the protective film on a side adjacent to the phase-shift film, so as to inhibit counter diffusion in relation to the phase-shift film.
US Pat. No. 10,481,485

MASK BLANK, TRANSFER MASK, METHOD OF MANUFACTURING TRANSFER MASK AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE

HOYA CORPORATION, Tokyo ...

1. A mask blank comprising:a transparent substrate;
a thin film for pattern formation provided on a main surface of the transparent substrate;
an etching stopper film provided between the transparent substrate and the thin film for pattern formation,
wherein the thin film for pattern formation contains silicon;
wherein the etching stopper film is single layered film; and
wherein the etching stopper film contains silicon, aluminum, and oxygen.
US Pat. No. 10,479,946

SYSTEM AND PROCESS FOR INCREASING HEAVY OILS CONVERSION CAPACITY

Eni S.p.A., Rome (IT)

1. A system for heavy oils hydroconversion comprising:a reactor,
a liquid-vapor separator, and
a stripping section of conversion products, external to said reactor, comprising a connection conduit between a reactor head of said reactor and said liquid-vapor separator and a supply conduit for supplying stripping gas at a point of said connection conduit,
wherein said connection conduit is upwardly inclined, at least from the point of supply of the stripping gas, with a gradient of between 2% and 20% with respect to a horizontal plane,
wherein obstacles are inserted inside said connection conduit between said reactor head and said liquid-vapor separator, which facilitates intimate mixing of the liquid and vapor phases and makes it possible for liquid/vapor equilibrium to be achieved.
US Pat. No. 10,478,414

NEUROREGENERATION SUPPLEMENT

1. A composition for enhancing neuroregenation of peripheral nerves of a mammal consisting:between about 40 and 48 percent of L-glycine;
between about 10 and 15 percent L-glutamine; and
between about 30 and 37 percent D, L-phenylalanine of the composition.
US Pat. No. 10,481,495

TOPCOAT COMPOSITIONS CONTAINING FLUORINATED THERMAL ACID GENERATORS

Rohm and Haas Electronic ...

1. A topcoat composition, comprising:a matrix polymer;
a surface active polymer;
an ionic thermal acid generator comprising an anion and a cation, wherein the anion, the cation, or the anion and the cation are fluorinated, wherein the cation is of the general formula (I):
(BH)+  (I)
which is the monoprotonated form of a nitrogen-containing base B; and
a solvent.
US Pat. No. 10,479,700

SYSTEM AND METHOD OF DESALINATION

1. A method of desalination of sea water, comprising:provision of a sealed reservoir disposed at the edge of the sea, comprising a filling device disposed on the roof, along with one or more openings disposed below sea level and being in communication with the sea;
filling of the reservoir with sea water by the filling device, with the openings being hermetically sealed, followed by closing of the filling device to render the reservoir sealed;
opening of the openings, placing the water which is inside the reservoir in communication with the water of the sea, wherewith the water level in the reservoir will decrease and will stabilize at a height h above the level of the sea, wherewith water vapor is produced in the reservoir above said height h, and wherewith the ceiling of the reservoir will have a height above the level of the sea greater than the height h to allow treatment of the water vapor produced in the reservoir;
condensation of the water vapor produced, to obtain desalinated water; and
removal of water from the water surface located at a height h in the reservoir toward the sea, in order to maintain the temperature of the water at the surface of the reservoir at the temperature of the water of the sea.
US Pat. No. 10,478,163

MEDICAL INSTRUMENT ENGAGEMENT PROCESS

Intuitive Surgical Operat...

1. A method for operating a medical instrument and a drive system, the medical instrument comprising at least one component, comprising:bringing a first feature on a rotatable element of the medical instrument into contact with a second feature on a drive element of the drive system without restricting a rotation angle of the first feature relative to the second feature, the second feature being shaped to engage the first feature, and the medical instrument including a mechanism coupled to the rotatable element and coupled to actuate the at least one component of the medical instrument in response to rotation of the rotatable element;
applying an engagement force to create friction between the first and second features, wherein bringing the first feature into contact with the second feature and applying the engagement force engages the first and the second features without inducing rotation that actuates the medical instrument; and
operating the drive system to rotate the drive element and the rotatable element, wherein the friction transfers torque that the drive element applies to the rotatable element to rotate the rotatable element and thereby to actuate the component.
US Pat. No. 10,478,420

ORAL FORMULATIONS OF PYRROLIDINE DERIVATIVES

ObsEva S.A., Plan-les-Ou...

1. A method of treating infertility in a human patient, the method comprising administering to the patient a dispersible tablet comprising a substantially pure form of (3Z,5S)-5-(hydroxymethyl)-1-[(2?-methyl-1,1?-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime and one or more pharmaceutically acceptable excipients.
US Pat. No. 10,477,908

ACRYLIC FIBER FOR ARTIFICIAL HAIR, METHOD FOR PRODUCING SAME, AND HEAD DECORATION PRODUCT COMPRISING SAME

KANEKA CORPORATION, Osak...

1. An acrylic fiber for artificial hair, comprising an acrylic polymer and an organic solvent that can dissolve the acrylic polymer,wherein the acrylic polymer comprises, with respect to a total weight of the acrylic polymer, 29.5 to 79.5% by weight of acrylonitrile, 20 to 70% by weight of vinyl chloride and/or vinylidene chloride, and 0.5 to 5% by weight of a sulfonic acid-containing vinyl monomer,
wherein a content of the organic solvent in the acrylic fiber is 0.1 to 3% by weight, and
wherein the acrylic fiber has a single fiber fineness of 30 to 100 dtex.
US Pat. No. 10,479,963

MICROCAPSULES CONTAINING MICROORGANISMS

Devan Chemicals NV, Rons...

1. A composition comprising a microorganism within unruptured microcapsules, the composition comprising:friable microcapsules having a diameter from 1 to 300 ?m in a concentration of from 0.1% to 50% by weight of the composition dispersed within an aqueous treatment solution, the microcapsules being present in the composition in an amount for the microcapsules to be applied at a level of 0.1 to 20 gram/m2 when applied to a textile surface, the microcapsules adapted for delivery of a liquid onto the textile by rupture during conventional use of said textile, the microcapsules comprising a shell encapsulating the liquid to form a liquid core, the liquid containing a microorganism that consumes organic matter deposited on the textile surface;
wherein said microorganism is in a vegetative state, and is brought back into a reproductive state by contact with oxygen and moisture upon the rupture of the microcapsule.
US Pat. No. 10,478,939

POLISHING METHOD

FUJIMI INCORPORATED, (JP...

1. A polishing method for polishing an object to be polished containing tungsten and at least one of silicon oxide film and silicon nitride by using a polishing composition, the polishing method comprisingequalization of the surface zeta potential of said tungsten and at least one of said silicon oxide film and said silicon nitride,wherein the equalization is carried out by including a potential equalizing agent having an adsorbing group for adsorption onto said tungsten and at least one of said silicon oxide film and said silicon nitride and a functional group for providing zeta potential in the polishing composition,wherein the potential equalizing agent is dicyandiamide diethylenetriamine formalin condensate.
US Pat. No. 10,478,432

COMPOSITIONS OF MATTER FOR TREATMENT OF OPHTHALMIC CONDITIONS BY SELECTIVELY REMOVING SENESCENT CELLS FROM THE EYE

Unity Biotechnology, Inc....

1. A unit dose of a pharmaceutical composition formulated for treating of an ophthalmic disease or disorder in a subject in need thereof;wherein the ophthalmic disease is not a cancer;
wherein the composition comprises an amount of a small-molecule means for selectively inhibiting Bcl-2 or Bcl-xL;
wherein the unit dose is formulated with an excipient in a volume suitable for intravitreal administration; and
wherein the formulation of the composition and the amount of the means for selectively inhibiting Bcl-2 or Bcl-xL in the unit dose configure the unit dose to be effective in selectively killing p16 positive senescent cells in the eye that are causing adverse symptoms of the ophthalmic disease or disorder in the subject when administered to the subject intravitreally as a single dose.
US Pat. No. 10,479,726

FIBERSIZING WITH SMALL AMOUNTS OF NANOMATERIALS

Evonik Degussa GmbH, Ess...

1. A nanoparticle-coated fibre material, comprising a fibre material and a coating on at least a portion of the fibre material, wherein:the coating comprises from 0.01 wt % to less than 0.4 wt % of nanoparticles based on a dry weight of the nanoparticle-coated fibre material;
the coating is capable of undergoing further reactions; and
the nanoparticles comprise surface-modified spherical silica nanoparticles.
US Pat. No. 10,478,448

METHODS AND COMPOSITIONS FOR MODULATING APOLIPOPROTEIN (A) EXPRESSION

Ionis Pharmaceuticals, In...

1. A method of treating, slowing the progression of, or ameliorating a symptom of hyperlipidemia in a subject, comprising:administering to said subject a compound comprising a modified oligonucleotide, wherein:
the modified oligonucleotide consists of 14 to 25 linked nucleosides and comprises a nucleobase sequence comprising a portion of at least 14 contiguous nucleobases complementary to an equal length portion of nucleobases 3900 to 3923 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 95% complementary to SEQ ID NO: 1, including any salt thereof, whereby the administration treats, slows the progression of, or ameliorates a symptom of hyperlipidemia in the subject.
US Pat. No. 10,479,986

NUCLEIC ACID CONSTRUCTS AND METHODS FOR LABELING AND DETECTING NUCLEOSOMAL DNA MODIFICATIONS

The Broad Institute, Inc....

1. A method for labeling nucleic acids from a cell or population of cells comprising:providing one or more individual discrete volumes, each individual discrete volume comprising a cell or population of cells;
lysing the cell or population of cells in each individual discrete volume and fragmenting nucleosomal DNA from the lysed cell or population of cells;
labeling the fragmented nucleosomal DNA in each individual discrete volume with a barcoded adapter on at least one free end of the fragmented nucleosomal DNA, wherein:
the barcoded adapter comprises an amplification promoter adjacent to a first or second read sequencing primer binding site which is adjacent to a barcode sequence,
the labeled nucleosomal DNA comprises, in a 3? to 5? orientation, a first read sequencing primer binding site, the nucleosomal DNA sequence, the barcode sequence, and a second read sequencing primer binding site,
the barcode sequence is unique to each individual discrete volume thereby identifying a sample from which the labeled nucleosomal DNA originated;
isolating and sequencing the labeled nucleosomal DNA from each sample; and
grouping the sequenced nucleosomal DNA by common barcode thereby identifying the individual discrete volumes from which the nucleosomal DNA originated.
US Pat. No. 10,478,449

2?-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS

Ionis Pharmaceuticals, In...

1. A composition comprising a first oligomer and a second oligomer, wherein:at least a portion of said first oligomer is capable of hybridizing with at least a portion of said second oligomer,
at least a portion of said first oligomer is complementary to and capable of hybridizing with a selected target nucleic acid,
each of said first and second oligomers are chimeric oligomers,
wherein the second oligomer has an internal segment comprising at least five consecutive nucleosides having a 2?-OCH3 substituent group, and
wherein the chimeric oligomers are not gapmers.
US Pat. No. 10,478,450

METHODS AND COMPOSITIONS FOR ADMINISTRATION OF IRON

Luitpold Pharmaceuticals,...

1. A method of treating a disease, disorder, or condition characterized by iron deficiency or dysfunctional iron metabolism resulting in reduced bioavailability of dietary iron, comprising administering to a subject in need thereof an iron carbohydrate complex in a single dosage unit of at least 0.7 grams of elemental iron, wherein:the iron carbohydrate complex is substantially non-immunogenic, and has substantially no cross reactivity with anti-dextran antibodies; and
the iron carbohydrate complex is an iron polyisomaltose complex.
US Pat. No. 10,479,989

COMPOSITIONS FOR MAKING RANDOM CODON-MUTANT LIBRARIES AND USES THEREOF

Fred Hutchinson Cancer Re...

1. A method for making a plurality of variant nucleic acid molecules, comprising(a) amplifying a reference nucleic acid molecule template with a plurality of forward mutagenic oligonucleotides to produce a first plurality of forward mutagenic fragments and separately amplifying the reference nucleic acid molecule template with a plurality of reverse mutagenic oligonucleotides to produce a first plurality of reverse mutagenic fragments, wherein the reference nucleic acid molecule template comprises a plurality of codons that encode a reference polypeptide and wherein each of the plurality of forward and reverse mutagenic oligonucleotides comprise a codon randomized at one to three nucleotides and the oligonucleotides comprise from nine to 100 nucleotides, and wherein the randomized codons correspond to all codons of the reference nucleic acid molecule template except the initiation codon;
(b) purifying the first plurality of forward and reverse mutagenic fragments and mixing the purified first plurality of forward and reverse mutagenic fragments to produce a first mixed mutagenic nucleic acid molecule fragment template composition; and
(c) joining the mixed nucleic acid molecule fragments of the first mixed mutagenic nucleic acid molecule fragment template composition by amplifying in a single reaction with the plurality of forward and reverse mutagenic oligonucleotides from step (a) to produce a first plurality of joined mutagenic nucleic acid molecules;
thereby introducing codon variants at random locations at a controlled mutation rate across the length of the reference nucleic acid molecule template.
US Pat. No. 10,479,992

RNA DUPLEXES WITH SINGLE STRANDED PHOSPHOROTHIOATE NUCLEOTIDE REGIONS FOR ADDITIONAL FUNCTIONALITY

Phio Pharmaceuticals Corp...

1. An isolated double stranded nucleic acid molecule comprising a guide strand and a passenger strand, wherein the passenger strand is 8-16 continuous nucleotides in length, wherein the isolated double stranded nucleic acid molecule comprises a double stranded region that is 8-16 nucleotides in length, wherein the guide strand is 19-25 nucleotides in length, and wherein the double stranded region is connected through a cleavable chemical linker to a single stranded region of at least six phosphorothioate modified nucleotides.
US Pat. No. 10,478,456

PHARMACEUTICAL PREPARATION

APOSCIENCE AG, Vienna (A...

1. A pharmaceutical preparation, comprising a dosage form of a cell-free culture supernatant of peripheral blood mononuclear cells (PBMCs), the cell-free culture supernatant comprising at least 2000 pg/mL of matrix metallopeptidase 9 (MMP-9) and no detectable amount of TNF-?, the PBMCs comprising non-activated, non-proliferating T cells, B cells, NK cells, and monocytes cultivated under a stress inducing condition comprising a dose of at least 10 Gy radiation in a physiological solution free of PBMC-proliferating and PBMC-activating substances for at least 1 h.
US Pat. No. 10,479,994

ROTATIONALLY SEQUESTERED TRANSLATORS

Emerald Therapeutics, Inc...

1. A composition comprising:(a) a first nucleic acid complex comprising (i) a first nucleic strand comprising, sequentially, a first, second and third fragments and defined as S-Q-P, wherein each letter denotes a fragment and a string of letters connected by “-” denotes a strand, and (ii) a second strand comprising, sequentially, a first, second, third and fourth fragments and defined as A- B- P- Q, wherein the first complex comprises a duplex region (Q-P::P- Q) formed between the second and third fragments of the first strand and the third and fourth fragments of the second strand; and
(b) a second nucleic acid complex comprising (i) a first nucleic acid strand comprising, sequentially, a first, second and third fragments and defined as P-B- ?, (ii) a second nucleic acid strand comprising, sequentially, a first, second and third fragments and defined as A-X-C, and (iii) a third strand comprising, sequentially, a first, second and third fragments and defined as D- X- B, wherein the second complex comprises a first duplex region (?::A) formed between the third fragment of the first strand and the first fragment of the second strand, a second duplex region (B::B) formed between the first fragment of the first strand and the third fragment of the third strand, and a third duplex region (X::X) formed between the second fragment of the second strand and the second fragment of the third strand,
wherein the first (S) fragment of the first strand of the first complex, the first (A) and second (B) of the second strand of the first complex, the first fragment (P) of the third strand of the second complex, the third fragment (C) of the second strand of the second complex, and the first fragment (D) of the third strand of the second complex are single-stranded; and
wherein the first, second and third fragments (A, B, P) of the second strand of the first complex have sequence complementarity to the third, second and first fragments (?, B, P) of the first strand of the second complex to allow binding therebetween, respectively.
US Pat. No. 10,479,995

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

WAVE LIFE SCIENCES LTD., ...

1. An oligonucleotide having the structure of:mG*SmGmCmAmC*SA*SA*SG*SG*SG*SC*SA*SC*RA*SG*SmAmCmUmU*SmC (SEQ ID NO: 360), or a pharmaceutically acceptable salt thereof, wherein:
*S represents a Sp phosphorothioate;
*R represents a Rp phosphorothioate; and
m represents a 2?-OMe modification to a nucleoside.
US Pat. No. 10,478,459

COMPOSITIONS AND METHODS FOR CELL TRANSPLANTATION

UNIVERSITE CATHOLIQUE DE ...

1. A combination comprising:a liquid cell suspension comprising adult liver-derived progenitor or stem cells and at least one factor Xa inhibitor which is a direct or indirect factor Xa inhibitor and is not an antithrombin activator, and
at least one thrombin inhibitor.
US Pat. No. 10,478,461

CELLULAR EXTRACTS

REGENICS AS, Oslo (NO)

1. A method of improving wound healing in a human subject, comprising:applying a composition comprising a trout egg cellular extract having a protein content of from about 210-270 mg/ml and an RNA content from about 3.51 to 4.68 mg/ml to a wound of said subject under conditions such wound healing is improved, wherein said improvement is selected from the group consisting of faster drying, faster reepithelialization, reduced inflammation, faster contraction, earlier remodeling, reduction in scar tissue and improved visual appearance of the wound and combinations thereof.
US Pat. No. 10,479,745

CATALYTIC ISOMERIZATION OF Z-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE TO E-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE

THE CHEMOURS COMPANY FC, ...

1. A process for isomerizing Z-1,1,1,4,4,4-hexafluoro-2-butene to E-1,1,1,4,4,4-hexafluoro-2-butene comprising:(a) providing a starting material comprising Z-1,1,1,4,4,4-hexafluoro-2-butene;
(b) contacting the starting material with a suitable catalyst in a reaction zone to produce E-HFO-1336mzz; and optionally,
(c) recovering the E-HFO-1336mzz,
wherein, when the contacting step is performed in the gas phase, the catalyst comprises chromium and less than 40% by weight alumina;
wherein when the contacting step is performed in the liquid phase, the catalyst comprises a metal halide wherein the metal halide is aluminum halide, antimony halide, tin halide, tantalum halide, titanium halide, niobium halide, molybdenum halide, iron halide, fluorinated chrome halide, or combinations thereof.
US Pat. No. 10,480,001

METHOD FOR THE GENERATION OF A MONOCLONAL PLANT CELL LINE

1. A method for the generation of a monoclonal plant cell line from a heterogeneous population of plant cells, comprising the following steps:(a) providing a heterogeneous population of plant cells;
(b) preparing a heterogeneous population of protoplasts from the heterogeneous population of plant cells, wherein at least one of the protoplasts from the prepared heterogeneous population of protoplasts is transformed with at least one expression vector encoding at least one fluorescent protein and a resistance against at least one selection agent;
(c) initiating cell wall regeneration in said heterogeneous population of protoplasts for fluorescence activated cell sorting (FACS);
(d) providing a cell deposition device containing feeder cells in liquid medium containing wells;
(e) sorting by FACS the prepared at least one protoplast from the heterogeneous population of protoplasts in which the cell wall regeneration has been initiated, wherein said at least one protoplast is highly fluorescent;
(f) separating the sorted at least one protoplast into at least one different liquid medium-containing well containing the feeder cells for monoclonal plant cell generation such that said at least one well for monoclonal plant cell line generation contains a single prepared protoplast permitted to directly contact the feeder cells;
(g) regenerating the single separated protoplast from said at least one well into a microcolony by co-cultivating the separated protoplast in the same well as the feeder cells; and
(h) removing the microcolony from the feeder cells and cultivating the microcolony in the presence of said at least one selection agent against which said at least one protoplast is transformed with said at least one expression vector encoding a resistance until a monoclonal plant cell line from said at least one protoplast is established.
US Pat. No. 10,478,464

COMPOSITIONS AND METHODS OF USE

Kirit Shah, Portland, OR...

1. A method of treating cancer in a subject comprising administering to the subject a composition comprising an effective amount of 8-hydroxyhexadecanoic acid, or a salt thereof, thereby treating said cancer;wherein said cancer is a lung cancer.
US Pat. No. 10,480,002

ALGAL BASED EDIBLE VACCINES

TRANSALGAE ISRAEL LTD., ...

1. An edible vaccine comprising a transgenic eukaryotic microalga, the transgenic microalga comprising an expression cassette comprising at least one polynucleotide encoding an exogenous antigen further comprising a polynucleotide encoding a vacuolar targeting peptide having the amino acid sequence set forth in any one of SEQ ID NO:1 and SEQ ID NO:9, wherein the encoded exogenous antigen is localized within the vacuole of the microalga cell, and wherein said encoded exogenous antigen induces an immune response in a target subject consuming said vaccine against a disease caused by a pathogen.
US Pat. No. 10,480,008

INSECTICIDAL POLYPEPTIDES HAVING BROAD SPECTRUM ACTIVITY AND USES THEREOF

POINEER HI-BRED INTERNATI...

1. An isolated nucleic acid molecule operably linked to a heterologous regulatory element, wherein said isolated nucleic acid is selected from the group consisting of:(a) a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 3;
(b) a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2 and SEQ ID NO: 4;
(c) a nucleic acid molecule comprising a nucleotide sequence encoding a protein, having insecticidal activity against soybean looper, comprising an amino acid sequence that differs by 1 to 3 amino acid resides compared to the amino acid sequence of SEQ ID NO: 4; and
(d) a nucleic acid molecule comprising a nucleotide sequence encoding a protein, having insecticidal activity against soybean looper, comprising an amino acid sequence that differs by 1 to 3 amino acid resides compared to the amino acid sequence of SEQ ID NO: 2.
US Pat. No. 10,478,471

IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer, comprising administering to said patient a composition comprising a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide, wherein said peptide consists of the amino acid sequence of VFIFKGNQF (SEQ ID NO: 18), wherein the peptide is in a complex with an MHC molecule.
US Pat. No. 10,478,473

COMPOSITIONS AND METHODS OF USING ANTI-MULLERIAN HORMONE FOR TREATMENT OF INFERTILITY

THE CENTER FOR HUMAN REPR...

1. A method for treating infertility in a subject comprising administering to the subject an effective amount of a composition comprising anti-Mullerian hormone (AMH), wherein the AMH comprises the amino acid sequence set forth in SEQ ID NO:1; and wherein the AMH is administered at a dose in the range of about 22,000 ng/day to about 44,000 ng/day for a period of time from about 30 days to about 90 days.
US Pat. No. 10,480,012

CYP-P22 BIOCATALYTIC NANOPARTICLES WITH CYTOCHROME P450 ACTIVITY FOR PRODRUG ACTIVATION

UNIVERSIDAD NACIONAL AUTO...

1. An immunologically inert and functionalized CYP-P22 biocatalytic nanoparticle that activates prodrugs in a target cell, comprisinga) a polypeptide sequence of SEQ ID NO:4 which is a fusion of a scaffold protein SP and a CYPBM3 protein,
b) a fragment of a P22 scaffold protein,
c) a coat protein of P22 bacteriophage,
d) a bifunctional dendritic polyethylene glycol, and
e) a cyclic polypeptide of SEQ ID NO: 5.
US Pat. No. 10,478,482

VACCINES FOR PREVENTION AND TREATMENT OF TUBERCULOSIS

ALARUM DEVELOPMENT LTD, ...

1. A method of eliciting an immune response against Mycobacterium tuberculosis in a mammalian subject comprising the step of administering to said subject an immunological composition consisting essentially of a first isolated polypeptide of the amino acid sequence of SEQ ID NO: 1, a second isolated polypeptide of the amino acid sequence of SEQ ID NO: 2, and a third isolated polypeptide of the amino acid sequence of SEQ ID NO: 3 and at least one of a pharmaceutically acceptable carrier and an adjuvant.
US Pat. No. 10,480,020

RAPID TEST FOR MICROBIAL RESISTANCES BY MASS SPECTROMETRY

1. Sample support for a mass spectrometric determination of the resistance of a microbial sample to be applied to the sample support, wherein the sample support plate is flat and has on its surface a multiplicity of test sites and at least one test site is coated with a dosed quantity of one or more antibiotics and with one or more reference substances.