US Pat. No. 10,426,894

DRUG DELIVERY DEVICE WITH INDICATOR

INSULET CORPORATION, Act...

1. An apparatus, comprising:a drug container configured to hold a liquid drug;
a plunger positioned in the drug container;
a drive system coupled to the plunger, the drive system configured to advance the plunger to expel a portion of the liquid drug from the drug container for delivery to a patient, the drive system comprising one or more spherical elements and a drive spring;
a Hall effect sensor positioned adjacent to the drug container; and
a controller coupled to the Hall effect sensor,
wherein the Hall effect sensor is configured to measure a varying magnetic field caused by the one or more spherical elements passing the Hall effect sensor,
wherein the Hall effect sensor is configured to generate a signal indicative of the measured varying magnetic field,
wherein the controller receives the signal generated by the Hall effect sensor and determines a count of a number of the one or more spherical elements that pass the Hall effect sensor.

US Pat. No. 10,426,893

DRUG DELIVERY DEVICE WITH THREADED HOUSING AND PISTON, AND METHOD FOR MANUFACTURING THE SAME

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising: a housing defining a longitudinal axis and having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face, wherein the bearing comprises a retaining stem protruding from the proximal face, wherein the piston rod comprises a distal portion having an outer diameter which is smaller than an inner diameter of the inner thread of the tubular portion, and, a retaining clip engaging the retaining stem at a distal end of the piston rod, and wherein an axial length of the tubular portion is smaller than or equal to an axial distance between the proximal face of the bearing and the distal end of the threaded portion of the piston rod.

US Pat. No. 10,426,891

DISPOSABLE CASSETTE FOR STORING AND DELIVERING A MEDICAL DRUG

1. An injector device comprising:a housing defining a cavity having a disposable cassette arranged therein, said housing comprising a movable lid allowing the disposable cassette to be inserted into or removed from the cavity,
a movable sledge configured to operate a valve block of the disposable cassette arranged in the cavity, and
a plunger activator arranged in abutment with a plunger of a cartridge of the disposable cassette arranged in the cavity, the plunger activator being configured to operate the plunger in order to cause a medical drug to be delivered,
wherein the disposable cassette comprises:
the cartridge containing the medical drug,
a waste reservoir arranged to receive waste liquid and/or gas,
an injection needle or an injection needle mounting interface for mounting an injection needle arranged to deliver the medical drug, and
the valve block being movable between a first position and a second position, the first position establishing a fluid passage between the cartridge and the waste reservoir, while preventing fluid flow from the cartridge to the injection needle or the injection needle mounting interface, and the second position establishing a fluid passage between the cartridge and the injection needle or the injection needle mounting interface, while preventing fluid flow from the cartridge to the waste reservoir,
wherein the cartridge, the waste reservoir, the valve block and at least part of the injection needle or the injection needle mounting interface are arranged inside a cassette housing of the disposable cassette, and wherein the valve block is operable to be moved between the first position and the second position without a user operating the disposable cassette coming into direct contact with parts arranged inside the cassette housing.

US Pat. No. 10,426,890

DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drug delivery device comprising:a primary drug delivery assembly with a primary dose dial sleeve configured to move proximally in a helical movement during setting of a dose of a primary medicament contained in a primary reservoir of the primary drug delivery assembly and a secondary drug delivery assembly with a secondary drive sleeve configured to move in a proximal direction in a helical movement during setting of a dose of a secondary medicament contained in a secondary reservoir of the secondary drug delivery assembly
a selection switch movable between a first position, a second position, and a third position, wherein the first position is an intermediate position between the second position and the third position; and
a clutch connected to the selection switch such that movement of the selection switch causes rotation of the clutch,
wherein the clutch is configured to engage with and to transfer rotation to the secondary drive sleeve when the selection switch is moved from the first position into the second position such that the dose of the secondary medicament is set and to disengage from the secondary drive sleeve when the selection switch is moved from the first position into the third position such that the dose of the secondary medicament is not set, and
wherein a first engagement element is configured to rotate the primary dose dial sleeve in one direction to set the dose of the primary medicament, wherein the first engagement element is adapted to be engaged by the selection switch such that movement of the selection switch from the first position into the second position and from the first position into the third position causes the first engagement element to rotate the primary dose dial sleeve in the one direction such that a predetermined dose of the primary medicament is set.

US Pat. No. 10,426,889

OPTICAL DISPLACEMENT SENSOR FOR INFUSION DEVICES

DEKA PRODUCTS LIMITED PAR...

1. A medical fluid dispensing apparatus for pumping an infusible medical fluid to the body of a patient, the medical fluid dispensing apparatus comprising:a piston having an encoded pattern associated therewith; and
an optical sensor, wherein the optical sensor is configured to determine the position of the piston, relative to a fiducial position based on the encoded pattern during delivery regardless of whether the encoded pattern associated with the piston repeats.

US Pat. No. 10,426,886

SET OF CONTAINERS FOR USE ON A BLOOD COMPONENT CENTRIFUGAL SEPARATOR

Terumo Kabushiki Kaisha, ...

1. A disposable set of containers for use on a blood component centrifugal separator, said blood component centrifugal separator having a first pump, a second pump and a centrifuge rotor, the disposable set comprising:a separation container adapted to be mounted on the centrifuge rotor and having an inlet port and an outlet port;
a tube in fluid communication with a source of whole blood drawn from a blood donor and in further fluid communication with the separation container and adapted to engage the first pump,
a first container for receiving a predetermined first blood component, among centrifugally separated blood components, together with whole blood, said first container being in fluid communication with the outlet port of said separation container and with the inlet port of said separation container, and
a second tube adapted to engage the second pump and in fluid communication with said first container and said inlet port of said separation container,
a temporary storage container wherein whole blood drawn from the blood donor is temporarily stored, and
a third tube coupled to the temporary storage container further coupled to the outlet port of the separation container and a fourth tube also coupled to the temporary storage container and further coupled between the first container and the second tube and further comprising a fifth tube in fluid communication with said third tube and said first tube such that said second tube is connected to said first tube between said fifth tube and said inlet port of said separation container.

US Pat. No. 10,426,883

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

Baxter International Inc....

1. A hemodialysis system configured to purge air from a blood circuit, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
the blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, and
a drip chamber located along the venous line; and
an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged from the blood circuit using dialysis fluid or other physiologically acceptable fluid pumped through the dialysis fluid circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly to the blood circuit.

US Pat. No. 10,426,882

BLOOD RINSEBACK SYSTEM AND METHOD

Baxter International Inc....

1. A hemodialysis system configured to return blood to a patient, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
a blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,
a drip chamber located along the venous line;
a blood detector operable with the venous line; and
a blood rinseback scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, blood is pushed to the patient via the medical fluid being introduced from its source into the arterial line between the arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber and to the blood detector along the venous line, where the medical fluid is sensed by the blood detector to indicate an end of the blood rinseback.

US Pat. No. 10,426,872

NERVE REPAIR SCAFFOLDS HAVING HIGH MICROCHANNEL VOLUME AND METHODS FOR MAKING THE SAME

THE REGENTS OF THE UNIVER...

1. A method of making a tissue scaffold for neural tissue growth, the method comprising:admixing (i) a porogen having an average particle size of less than or equal to about 40 ?m with (ii) a polymeric precursor solution comprising a biocompatible and biodegradable polyester polymer precursor and a first solvent, to form a suspension;
contacting a template with the suspension to coat at least one surface of the template;
volatilizing at least a portion of the first solvent to form a coating;
removing the coating from the template; to create a microchannel;
assembling the microchannel inside a sheath with a plurality of other microchannels; and
removing the porogen to form a plurality of porous microchannels disposed within sheath thus creating the tissue scaffold.

US Pat. No. 10,426,867

BIOCOMPATIBLE POLYCAPROLACTONE FUMARATE FORMULATIONS

Mayo Foundation for Medic...

1. A scaffold for tissue regeneration, the scaffold comprising:a blend of a polymer having the Formula (I)
H-A1-B-A2-C-A1-B-A2-H  (I)
wherein
A1 is

A2 is

B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene,
C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene;
C is

and geometric isomers thereof;
and n is an integer from 1 to 50, and
a polymer having the Formula (II)

wherein
D1 is

D2 is

D3 is

E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl,
C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl;
F is
and geometric isomers thereof;and n is an integer from 1 to 50;
wherein the polymer of Formula (I) comprises 20 wt. % to 80 wt % of the scaffold, and the polymer of Formula (II) comprises 20 wt. % to 80 wt % of the scaffold, and
wherein the polymer of Formula (I) is formed using a first initiator such that B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene, C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene, and
wherein the polymer of Formula (II) is formed using a second initiator such that E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl, C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl, and
wherein the first initiator is different from the second initiator.

US Pat. No. 10,426,864

STORAGE APPARATUS HAVING AIR PURIFYING MODULE

SEOUL VIOSYS CO., LTD., ...

1. An air purifying system including,a case having a top surface that is flat, a bottom surface opposite to the top surface, and a side surface connecting the top surface and the bottom surface;
an air inlet arranged on the bottom surface to introduce an air from an exterior of the case to an interior of the case;
a circulation fan arranged inside the case and disposed to receive the air from the air inlet and to generate an air flow moving in a first direction, wherein the top surface of the case is connected to the side surface though a rounded corner structured to cause at least a portion of the generated air flow to change an air flow direction to a second direction, the air moving in the second direction along the top surface,
a light emitting diode part arranged above the air inlet and including a light emitting diode positioned to sterilize the air flow moving in the second direction;
an air outlet positioned to discharge the air to the exterior of the case; and
a collection filter arranged in the case and configured to capture bacteria to increase a sterilization efficiency of the air purifying system,
wherein the first direction is toward the top surface and the second direction is substantially perpendicular to the first direction.

US Pat. No. 10,426,857

SYSTEMS, DEVICES, AND METHODS INCLUDING IMPLANTABLE DEVICES WITH ANTI-MICROBIAL PROPERTIES

Gearbox, LLC, Bellevue, ...

1. An insertable device, comprising:a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;
circuitry configured to detect one or more microorganisms present proximate at least one of the outer surface, the inner surface, or the one or more fluid-flow passageways; and
one or more actively controllable anti-microbial regions included on at least one of the outer surface or the inner surface, or embedded in the body structure, at least one of the one or more actively controllable anti-microbial regions having a wettability switchable feature configured to actuate between a first anti-microbial state and a second anti-microbial state responsive to detection of at least one microorganism by the circuitry.

US Pat. No. 10,426,851

PROTECTIVE STERILIZATION SYSTEM

1. A protective sterilization system comprising:a protective container, having:
a first casing member having a body forming a storage space having:
the body extending from a first enclosed end to a first open end, the first enclosed end having at least a first side, a second side, and a third side, the third side being opposite the first open end and extending between the first side and the second side;
a bottom surface; and
a first protection device positioned within the storage space at the first enclosed end of the body and attached to at least the first side, the second side, and the third side of the first enclosed end and extending inwardly into the storage space from at least the first side, the second side, and the third side of the first enclosed end;
a plurality of support arms rigidly attached to the bottom surface of the storage space and configured to suspend an implement within the storage space of the container; and
a second casing member having a second enclosed end and a second open end and configured to removably attach to the first casing member at the first open end of the first casing and the second open end of the second casing member via tongue and grooves, the second casing member having:
a second protection device extending from the second enclosed end configured to hold the implement in a stationary position;
wherein the container when closed is sterilized to clean the implement.

US Pat. No. 10,426,843

DELTA-OPIOID RECEPTOR TARGETED AGENT FOR MOLECULAR IMAGING AND IMMUNOTHERAPY OF CANCER

1. A compound having Formula I,
wherein
n is an integer of from 1 to 50;
L1 and L2 are optional linking moieties of from 1 to 100 atoms in length; and
Ab is an antibody;
Tg* is H, a protecting group, or a detectable moiety; and
Dmt-Tic is represented by

where R1 and R2 are independently selected from H and CH3.

US Pat. No. 10,426,830

ALTERING THE IMMUNDOMINANCE HIERARCHY USING A DNA VACCINE EXPRESSING CONSERVED REGIONS

THE UNITED STATES OF AMER...

1. A method of inducing an immune response to an HIV protein, the method comprising administering:a first nucleic acid encoding a first conserved element polypeptide, wherein the conserved elements are from the HIV protein and the polypeptide comprises at least six conserved elements, each less than 50 amino acids in length, where the conserved elements are joined by linkers;
a second nucleic acid encoding a second conserved element polypeptide that comprises a variant of each of the at least six conserved elements contained in the first conserved element polypeptide, wherein each variant in the second conserved element polypeptide differs from the corresponding conserved element in the first conserved element polypeptide by at least 1, 2, or 3 amino acids; and
after administration of the first and the second nucleic acids, administering a nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, wherein the nucleic acid encoding the full-length HIV protein or substantially full-length HIV protein is administered at least two weeks after the first and second nucleic acids encoding the conserved element polypeptides; and further, wherein the nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, is administered as a plasmid that comprises an expression cassette comprising a nucleic acid sequence encoding the full-length HIV protein, or substantially full-length HIV protein, operably linked to a promoter.

US Pat. No. 10,426,739

ADHESIVE PATCH ASSEMBLY WITH OVERLAY LINER AND SYSTEM AND METHOD FOR MAKING SAME

3M Innovative Properties ...

15. A method of making an article comprising an adhesive patch assembly, the method comprising the steps of:providing a patch having a periphery, the patch including a backing, a skin-contact adhesive coupled to the backing, a drug, and a skin penetration enhancer;
providing a release liner including a first major surface and a second major surface opposite the first major surface, at least the first major surface configured to present release characteristics relative to the skin-contact adhesive of the patch, the release liner having a first portion and a second portion, wherein each of the first portion and the second portion are dimensioned to accommodate the patch, and wherein the release characteristics of the first major surface of the first portion of the release liner are coextensive with the first major surface of the second portion of the release liner;
including a slit into the second portion of the release liner, wherein the second portion further comprises two separate sections separated by the slit;
positioning the patch on the release liner, such that patch is located on the second portion of the release liner and the first portion of the release liner is free of the patch, wherein when the patch is located between the first portion and the second portion of the release liner the first and second portions having said release characteristics extend a distance beyond the periphery of the patch;
folding the release liner about a hinge located between the first portion and the second portion to locate the patch between the first portion and the second portion of the release liner and to form an adhesive patch assembly; and
packaging the adhesive patch assembly in a separate and distinct hermetically-sealed pouch.

US Pat. No. 10,426,730

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A microsphere comprising:a first biodegradable polymer encapsulating at least one additional microsphere, the at least one additional microsphere including a second biodegradable polymer and at least one bioactive agent, wherein the first biodegradable polymer and the second biodegradable polymer are different and one of the first biodegradable polymer or the second biodegradable polymer is oxidized cellulose.

US Pat. No. 10,426,727

FLUOROPOLYMER EMULSIONS WITH BRANCHED SEMIFLUORINATED BLOCK COPOLYMER OR PHOSPHOLIPID SURFACTANT FOR THE DELIVERY OF HYDROPHOBIC DRUGS

Wisconsin Alumni Research...

2. An emulsion for delivery of a therapeutic agent, said emulsion comprising:an aqueous solution;
semi-fluorinated block copolymers; wherein each of said semi-fluorinated block copolymers independently comprises a hydrophilic block, a hydrophobic block and a fluorophilic block; wherein each of said semi-fluorinated block copolymers has a branched structure wherein said hydrophilic block comprises a first branch, said hydrophobic block comprises a second branch and said fluorophilic block comprises a third branch; and
said therapeutic agent comprising a hydrophobic compound;
said emulsion comprising a continuous phase and a dispersed phase, wherein said continuous phase comprises said aqueous solution and said dispersed phase comprises said semi-fluorinated block copolymers and said therapeutic agent;
wherein each of said semi-fluorinated block copolymers independently has the formula (FX9A) or (FX9B):

wherein q is an integer selected from the range of 10 to 300, o is an integer selected from the range of 5 to 20, and p is an integer selected from the range of 3 to 15.

US Pat. No. 10,426,702

MIXING AND/OR TRANSFERRING DEVICE

1. A device for mixing or transferring a first substance and a second substance that are present, respectively, in a first and a second receptacle, comprising:a first adapter having a circumferential wall, and being configured to accept the first receptacle, and along which extends, and which, at least in sections, surrounds a first cannula body, and a first hollow-cylindrical section connected to the first cannula body,
a second adapter having a circumferential wall, and being configured to accept the second receptacle, and along which extends, and which, at least in sections, coaxially surrounds, a second cannula body, and a second hollow-cylindrical section connected to the second cannula body,
wherein, in an assembled state, the first hollow-cylindrical section inter-engages with the second hollow-cylindrical section, and the first adapter and the second adapter are screwably and detachedly connected,
wherein each of the first and the second adapters comprises a hollow-cylindrical outer body with an exterior circumferential wall, and a partition wall extending perpendicularly to a longitudinal axis of the outer body,
wherein, when the first and second adapters are assembled together, a section, which has an inner thread, of the outer circumferential wall of one of the first and the second adapters surrounds a section, which has an external thread, of the outer circumferential wall of the other of the first and the second adapters, with inter-engaging threaded sections,
wherein the hollow-cylindrical outer body of at least one of the first and second adapters comprises an insert, having a circumferential wall, that accepts the first or the second receptacle, and
wherein the circumferential wall of the insert extends, at least in sections of the interior surface of the outer circumferential wall, spaced-apart from the interior surface of the outer circumferential wall.

US Pat. No. 10,426,700

SYRINGE ACCESSORY FOR TRANSFER OF AIR SENSITIVE MATERIALS

International Business Ma...

1. An apparatus for transferring fluid contained in a syringe, comprising:an airlock component having a cylindrical body, the cylindrical body having a first end, a second end, and a hollow tube disposed between the first end and the second end, wherein the hollow tube has an interior surface and an exterior surface;
an annular opening at the first end of the cylindrical body;
a gas inlet aperture from the exterior surface of the hollow tube to the interior surface of hollow tube;
a gas outlet aperture from the interior surface of the hollow tube to the exterior surface of the hollow tube;
an inwardly-facing airtight material coupled to the interior surface of the hollow tube; and
a septum coupled to the second end of the cylindrical body.

US Pat. No. 10,426,697

COMPACT ELECTRO-MECHANICAL CHEST COMPRESSION DRIVE

Koninklijke Philips N.V.,...

1. A cardio-pulmonary compression device, comprising:a motor having a rotating portion;
a ball nut mounted on the rotating portion and configured to rotate with the rotating portion;
a ball screw being received in the ball nut such that rotation on the ball nut advances and/or retracts the ball screw in accordance with a direction of the motor;
a pad assembly coupled to an end portion of the ball screw such that longitudinal motion of the ball screw imparts a compression cycle to a patient.

US Pat. No. 10,426,695

SYSTEM AND METHOD FOR CARDIOPULMONARY RESUSCITATION

COVIDIEN LP, Mansfield, ...

1. A method for determining an efficacy of cardiopulmonary resuscitation (CPR), the method comprising, using a processor configured to determine the efficacy of CPR, wherein the processor is associated with a patient monitor, an oximetry sensor, and an electrocardiogram (ECG) sensor, and wherein determining the efficacy of CPR comprises:receiving, at the processor, a plethysmography signal from the oximetry sensor;
receiving, at the processor, an ECG signal from the ECG sensor;
determining a first indicator related to the efficacy of CPR based on the plethysmography signal, using the processor;
determining a second indicator related to the efficacy of CPR based on the ECG signal, using the processor;
combining the first indicator and the second indicator to determine a combination metric indicative of the efficacy of CPR, using the processor; and
adjusting parameters controlling one or both of a rate or depth of compressions applied by a CPR device based on the combination metric.

US Pat. No. 10,426,617

LOW PROFILE VALVE LOCKING MECHANISM AND COMMISSURE ASSEMBLY

BOSTON SCIENTIFIC SCIMED,...

1. A replacement heart valve locking mechanism, comprising:a buckle member fixedly attached to a tubular anchor member;
a post member axially translatable relative to the buckle member; and
an actuator member releasably connected to the post member at an attachment point;
wherein the post member includes a latch portion configured to engage a catch formed in the buckle member such that movement of the post member distally relative to the buckle member is prevented;
wherein the attachment point is disposed proximal of the latch portion;
wherein the post member includes a cantilevered leg extending proximally from a distal end of the post member and radially inward from the tubular anchor member;
wherein distal movement of the actuator member relative to the post member is configured to disengage the latch portion from the catch.

US Pat. No. 10,426,609

FIBER REINFORCED PROSTHETIC HEART VALVE HAVING UNDULATING FIBERS

Boston Scientific Scimed,...

1. A prosthetic heart valve comprising:a plurality of leaflets comprising:
a composite material comprising a first plurality of polymeric fibers embedded in a polymer matrix, each fiber of the first plurality of polymeric fibers having a first common extending direction and a plurality of regularly spaced repeating undulations, wherein the plurality of regularly spaced repeating undulations of the first plurality of polymeric fibers is adapted to provide the composite material with multi-stage elastic properties; and
wherein the plurality of regularly spaced repeating undulations of the first plurality of polymeric fibers has crests that extend in a direction orthogonal to the first common extending direction;
wherein each leaflet comprises a first sleeve portion, a second sleeve portion, and a body portion disposed between the first and the second sleeve portions; and
wherein at least a portion of the first plurality of polymeric fibers extend along a linear path along the first common extending direction comprising a circumferential direction between the first sleeve portion and the second sleeve portion.

US Pat. No. 10,426,608

REPOSITIONABLE HEART VALVE

BOSTON SCIENTIFIC SCIMED,...

1. A replacement heart valve assembly comprising:an expandable anchor having a delivery configuration and a fully deployed configuration, the expandable anchor comprising a skirt region, a lip region, and a groove region therebetween;
in the delivery configuration, the expandable anchor having a first diameter and a first length and in the fully deployed configuration having a second diameter and a second length, wherein the first length is greater than the second length and the second diameter is greater than the first diameter;
a replacement valve disposed within the expandable anchor, the replacement valve including posts and hoop regions, the posts and hoop regions having a collapsed delivery configuration and an expanded deployed configuration in which the hoop regions are adapted to engage the groove region of the expandable anchor in the fully deployed configuration thereof;
the lip region of the expandable anchor is configured and adapted to expand radially outward relative to the groove region while transitioning from the delivery configuration to the fully deployed configuration to engage native valve leaflets and to provide positive registration and ensure accurate placement of the expandable anchor relative to a valve annulus during deployment.

US Pat. No. 10,426,607

APPARATUS FOR REPLACING A NATIVE HEART VALVE AND METHOD OF MAKING THE SAME

BOSTON SCIENTIFIC SCIMED,...

1. An apparatus for replacing a native heart valve comprising:an expandable anchor having a central longitudinal axis;
a replacement heart valve attached to the expandable anchor; and
a plurality of rivets;
the expandable anchor comprising a woven braid structure surrounding at least a portion of the replacement heart valve, the woven braid structure having a plurality of braid intersections, each braid intersection having a first wire segment and a second wire segment overlapping the first wire segment,
wherein the woven braid structure defines an inflow end and an outflow end;
each of the plurality of rivets extending through the first wire segment and the second wire segment at one of the plurality of braid intersections along a radial axis normal to the central longitudinal axis,
wherein at least some of the plurality of braid intersections of the woven braid structure between the inflow end and the outflow end of the woven braid structure are free of the plurality of rivets;
wherein the first wire segment is hingeable with respect to the second wire segment along the radial axis,
a plurality of buckles attached to the expandable anchor; and
a plurality of posts insertable into the plurality of buckles;
wherein the plurality of rivets is disposed between the plurality of posts at consecutive braid intersections along the inflow end of the woven braid structure.

US Pat. No. 10,426,602

INTRAOCULAR LENS (IOL) INJECTOR AND METHOD OF USE THEREOF

AST Products, Inc., Bill...

1. An intraocular lens (IOL) injector comprising:a) an injector body elongated along a longitudinal axis, the injector body having a lumen disposed along the longitudinal axis;
b) a lens cartridge in operable connection with the injector body, the lens cartridge having a lumen configured to receive an IOL and a positioning mechanism for folding and aligning the IOL in the lens cartridge lumen, wherein the lens cartridge lumen is coextensive with the injector body lumen;
c) an injector tip in operable connection with the lens cartridge, the injector tip having a lumen disposed along the longitudinal axis and terminating in a distal opening, wherein the injector tip lumen is coextensive with the injector body lumen;
d) a plunger having an elongated shaft, the elongated shaft being slidably disposed within the injector body lumen from an undeployed position to a deployed position, wherein the plunger is configured to contact the IOL in the lens cartridge lumen and push the IOL along the longitudinal axis through the injector tip lumen and out of the distal opening when the plunger is transitioned to the deployed position; and
e) a sleeve in operable connection with the lens cartridge, wherein the lens cartridge is configured to fold the IOL and align the IOL within the lens cartridge lumen via the positioning mechanism upon moving the sleeve over the lens cartridge from a first position to a second position, the sleeve covering at least a portion of the lens cartridge in the second position, wherein the positioning mechanism comprises a first cartridge portion having a surface adapted to contact an internal surface of the sleeve and urge the first cartridge portion toward a second cartridge portion when the sleeve is moved from the first position to the second position.

US Pat. No. 10,426,599

MULTIFOCAL LENS HAVING REDUCED CHROMATIC ABERRATIONS

Novartis AG, Basel (CH)

1. A multifocal ophthalmic lens comprising:an anterior surface;
a posterior surface; and
at least one diffractive structure including a plurality of echelettes having at least three different step heights of at least one wavelength and not more than two wavelengths in optical path length, the at least one diffractive structure residing on at least one of the anterior surface and the posterior surface, the at least one diffractive structure providing:
a first diffractive order for a first focus corresponding to a first focal length;
a second diffractive order for a second focus corresponding to a second focal length, the second focal length being different from the first focal length;
a third diffractive order for a third focus corresponding to a third focal length, the third focal length being different from the first focal length and the second focal length;
a fourth diffractive order for a fourth focus corresponding to a fourth focal length, the fourth focal length being different from the first focal length and the second focal length and the third focal length; and
wherein the diffractive structure excludes a 0th diffractive order.

US Pat. No. 10,426,598

IMAGE PROCESSING METHOD AND SYSTEM FOR IRREGULAR OUTPUT PATTERNS

Monash University, Clayt...

1. A visual image processing system comprising:a sensor input configured to receive spatial field information from an associated spatial field sensor;
a data store containing a sensor map data structure which comprises a set of predefined regions within a spatial field corresponding with the information received via the sensor input, wherein each predefined region is associated in the data structure with one or more of a set of stimuli applicable to a biological visual system, each stimulus corresponding to a visual percept;
a visual image processor configured to process spatial field information associated with each region to generate stimulus control information, and to apply the stimulus control information to select, from within the sensor map data structure, stimuli from the set of stimuli for application to the biological visual system;
a signal generator configured to receive the selected stimuli from the visual image processor, and to generate corresponding output stimulus signals for application to the biological visual system; and
an auxiliary image source configured to provide spatial field information in place of information received from the spatial field sensor, wherein spatial field information provided by the auxiliary image source comprises one or more predetermined test images; and
a visualisation system configured to display a simulated image representative of the sensory experience of a subject associated with the biological visual system;
wherein the data store contains a percept map data structure comprising information relating to the location and appearance of visual percepts experienced by the subject in response to stimuli within the set of stimuli.

US Pat. No. 10,426,597

SOFT TISSUE REBALANCING DEVICE AND METHOD

1. A soft tissue rebalancing method to rebalance a phalanx comprising the steps of:forming a mesh body portion having a ligament mesh portion and a braided mesh portion;
positioning the mesh body portion on a phalanx;
connecting the ligament mesh portion to a driver tool;
tensioning the ligament mesh portion to increase the tension of the mesh body portion on the phalanx;
performing transverse plane correction on the phalanx.

US Pat. No. 10,426,591

EMBOLIC DEFLECTION DEVICE

Edwards Lifesciences AG, ...

1. A method of reducing the risk of emboli entering the cerebral circulation as a consequence of an index procedure in the heart or the aorta, comprising the steps of:placing a wire through a first side branch vessel and into the aortic arch;
advancing an elongated introducer sheath over the wire and along the first side branch vessel until a distal end of the sheath is positioned in the aortic arch, wherein the elongated introducer sheath houses an expandable emboli deflection device attached to a distal end of an elongate shaft, the emboli deflection device having an elongated periphery in plan view when expanded, the periphery defined by a Nitinol skeleton in a modified rectangle with straight longitudinal sides terminating in opposite rounded ends, the periphery having a concave depth profile with a concave side facing toward the shaft, the emboli deflection device having a porous material stretched over the skeleton, the material having pores to allow the flow of blood but deflect or trap emboli;
retracting the sheath to expose and permit the emboli deflection device to expand;
manipulating the emboli deflection device such that the concave side covers the ostia of each of the first side branch vessel and a second side branch vessel, wherein manipulating the deflection device comprises pulling the shaft to create a seal between the periphery of the emboli deflection device and a wall of the aortic arch around the ostia of the first and second side branch vessels;
wherein the emboli deflection device permits blood flow from the main vessel into each of the first and second side branch vessels, but deflects emboli from entering the first and second side branch vessels;
performing an index procedure in the heart selected from the group consisting of a balloon aortic or mitral valvuloplasty, a mitral or aortic valve replacement, and a coronary angioplasty; and
retracting the emboli deflection device into the sheath and withdrawing the sheath from the body.

US Pat. No. 10,426,590

FILTERS WITH ECHOGENIC CHARACTERISTICS

VOLCANO CORPORATION, San...

1. A filter comprising:a hub; and
a plurality of legs or wires or segments extending from the hub; wherein the plurality of legs or wires or segments comprise a first section having a first pattern of voids formed therein to provide an enhanced echogenic characteristic of the first section and a second section having a second pattern of voids formed therein to provide an enhanced echogenic characteristic of the second section, wherein the first pattern of voids is different than the second pattern of voids.

US Pat. No. 10,426,586

SACROCOLPOPEXY SUPPORT

1. A sacrocolpopexy support comprising:a head section extending from a first end portion to a second end portion;
a leg section having a first leg portion placed on and in longitudinal alignment with a second leg portion;
a first connector securing the leg section to the second end portion of the head section; and
a second connector securing the first leg portion to the second leg portion to form a closed joint that defines a space between the first leg portion and the second leg portion;
wherein an end of the second end portion of the head section terminates at a location exterior to the closed joint outside of the space between the first leg portion and the second leg portion.

US Pat. No. 10,426,585

FECAL INCONTINENCE TREATMENT DEVICE AND METHOD

Boston Scientific Scimed,...

1. An implant device for treating fecal incontinence in a patient, comprising:a restriction member having a first end portion, a second end portion, and an intermediate restriction portion adapted to wrap around a portion of an anal sphincter of the patient, the intermediate restriction portion including a first portion and a second portion, the first portion including interwoven filaments and extending from the first end portion to the second end portion, the second portion including a plurality of non-woven struts and extending from the first end portion to the second end portion, the plurality of non-woven struts being interwoven with the interwoven filaments, the plurality of non-woven struts including voids configured to increase tissue in-growth, the voids being disposed between the plurality of non-woven struts;
at least two first connector elements provided at the first end portion; and
at least two second connector elements provided at the second end portion and adapted to connect with the at least two first connector elements to retain the restriction member around the anal sphincter of the patient to promote continence.

US Pat. No. 10,426,584

METHOD OF TREATING URINARY INCONTINENCE BY IMPLANTING A RESERVOIR AROUND A URETHRA OF THE USER

1. A method of treating urinary incontinence, the method comprising:implanting one and only one reservoir in a body of a user by placing the reservoir around a urethra of the user, where the reservoir includes a first compartment and a storage compartment having a pathway communicating with the first compartment;
placing a liquid in the reservoir;
implanting a pump in the body of the user, with the pump communicating with the reservoir;
operating the pump and moving the liquid from the first compartment to the storage compartment thus relieving a constriction of the urethra and allowing the user to pass urine through the urethra; and
configuring the reservoir to move the liquid from the storage compartment through the pathway to the first compartment and constricting the urethra of the user in providing the user with urinary continence.

US Pat. No. 10,426,583

HIGH TRANSLUCENT COLORED DENTAL ZIRCONIA BLANK

20. A colored zirconia sintered body comprising:a) a sintered body comprising zirconia containing between 6.0 wt % to 20 wt % of yttria (Y2O3);
b) the sintered body having multiple different colored layers;
c) at least one of the colored layers having a total light transmittance of at least 50% to light with a wavelength at a point between 600 nm and 800 nm;
d) a difference in total light transmittance between at least two adjacent vertical layers being less than 2% to light with wavelength of 600 nm, with a layer on one side having lower total light transmittance than a layer on the other side, with a translucency increasing from one side to the other side.

US Pat. No. 10,426,576

METHOD FOR DEBONDING OF ORTHODONTIC METAL BRACKETS WITH EUGENOL EMULGEL

King Abdulaziz University...

1. A method for removing an object bound to a tooth or teeth via a dental cement or dental resin, comprising:contacting the dental cement or dental resin with a gel comprising eugenol for a time sufficient to reduce Vickers hardness of the dental cement or dental resin or for a time sufficient to decrease debonding force needed to remove a metal bracket, dental appliance or dental prosthetic from the tooth or teeth, and
removing the metal bracket, dental appliance or dental prosthetic from the tooth or teeth.

US Pat. No. 10,426,552

REDUCTION METHODS FOR ALIGNING BONE SEGMENTS USING CUSTOMIZED JIGS

1. A reduction method for aligning a first bone segment and a second bone segment comprising:surgically attaching: (i) a first interaction implant to the first bone segment; and (ii) a second interaction implant to the second bone segment;
imaging the first and second bone segments to create a model;
processing the model to find an optimal bone alignment;
generating, based on the optimal bone alignment and with a three-dimensional printer, a custom jig, wherein the custom jig includes a global jig element, a first local jig element, and a second local jig element;
attaching the first local jig element to the first interaction implant;
attaching the second local jig element to the second interaction implants; and
engaging, after attaching the custom jig to the first and second interaction implants, the first and second local jig elements with the global jig element;
wherein the first and second bone segments are translated as the first and second local jig elements are engaged with the global jig element; and
wherein the first bone segment and second bone segment are properly aligned in the optimal bone alignment.

US Pat. No. 10,426,549

METHODS FOR PATIENT-SPECIFIC SHOULDER ARTHROPLASTY

Biomet Manufacturing, LLC...

1. A method of positioning a virtual guide on a virtual model of a patient's scapula for installing a glenoid implant, the method comprising:creating the virtual model of a patient's scapula using software run by a processor, the virtual model created from an anatomical image of the patient's scapula;
identifying at least a first point on an anterior rim of a glenoid fossa and a second point on a posterior rim of the glenoid fossa of the virtual model; and
positioning the virtual guide on the virtual model of the glenoid fossa as a function of the first point on the anterior rim and the second point on the posterior rim.

US Pat. No. 10,426,547

SURGICAL LASER SYSTEM AND LASER FIBER

Boston Scientific Scimed,...

1. An optical device, comprising:a controller coupled to a first treatment laser source and a first aiming laser source, wherein the controller is configured to:
in response to a request to discharge the first treatment laser source from a non-discharged state, discharge the first aiming laser source from a non-discharged state to deliver a first aiming beam in a first direction, and discharge the first treatment laser source from the non-discharged state to deliver a first laser energy in the first direction, wherein the first laser energy has a first wavelength configured to perform a first treatment, and the first aiming beam does not cause tissue damage.

US Pat. No. 10,426,516

TROCAR SEAL SYSTEM

Covidien LP, Mansfield, ...

1. A surgical access apparatus, which comprises:an access member defining a longitudinal axis, the access member having a longitudinal opening to permit passage of a surgical object, the access member being dimensioned for insertion within body tissue to permit access to an underlying site, and defining proximal and distal ends, the access member including a housing segment and an elongated segment, the housing segment having internal walls that include a proximal wall surface and a lateral wall, the internal walls of the housing segment defining an object seal channel; and
an object seal mounted within the object seal channel of the housing segment, the object seal configured to move during manipulation of the surgical object, the object seal including:
a generally annular seal support; and
a seal member secured to the generally annular seal support, the seal member comprising:
a resilient material and a fabric material;
an inner seal segment defining an inner passage configured to permit passage of the surgical object in substantial sealed relation therewith;
an outer flange segment disposed radially outward of the generally annular seal support, the outer flange segment bending outwardly and having a radially outer-most free end disposed flat against only the proximal wall surface of the housing segment, the radially outer-most free end of the outer flange segment detached from the lateral wall of the housing segment; and
wherein the seal member defines at least one aperture adjacent the outer flange segment, the at least one aperture adapted for at least partial reception of the generally annular seal support.

US Pat. No. 10,426,515

TRANSSEPTAL ACCESS DEVICE AND METHODS

THE REGENTS OF THE UNIVER...

1. A method of performing a procedure in the left heart of a subject comprising the steps of:inserting a puncture needle and transseptal access sheath into the vasculature of the subject;
advancing the puncture needle and transseptal access sheath into the right ventricle;
guiding the puncture needle and transseptal access sheath to the inter-ventricular septum;
advancing the puncture needle through the inter-ventricular septum into the left ventricle;
advancing at least a portion of the transseptal access sheath over the puncture needle into the left ventricle;
removing the puncture needle such that the transseptal access sheath remains positioned across the inter-ventricular septum, thereby forming a passageway from the right ventricle to the left ventricle through the transseptal access sheath;
advancing an instrument through the transseptal access sheath into the left ventricle;
performing a procedure in the left ventricle with the instrument while the transseptal access sheath is maintained across the inter-ventricular septum; and
removing the instrument through the transseptal access sheath.

US Pat. No. 10,426,509

MEDIAN LOBE DESTRUCTION APPARATUS AND METHOD

NeoTract, Inc., Pleasant...

1. A system for treating a median prostatic lobe of a patient, comprising:a handle configured to remain outside the patient;
an actuator operable by a user after the system has been placed partially within a urethra;
an introducer coupled to the handle and configured to be placed within the urethra of the patient;
a needle advanceable from the introducer by operation of the actuator to move through a curved trajectory to align with the handle, the needle being extendable from a portion of the system placed within the urethra and the needle being sized and configured to form an initial penetration track within the median prostatic lobe, wherein the needle exits from a side of the introducer;
an elongate member including a cutting blade with a hooked distal end, the elongate member being advanceable within and beyond a distal end of the needle while the distal end of the needle is within the median prostatic lobe;
and an elongate cylindrical implant deliverable through the introducer to be implanted in a passageway through the median prostatic lobe;
wherein the system is configured to treat the median prostatic lobe by dissecting and removing a portion of the median prostatic lobe.

US Pat. No. 10,426,503

SYSTEM AND METHOD FOR PERFORMING SURGICAL PROCEDURES WITH A REUSABLE INSTRUMENT MODULE

Covidien LP, Mansfield, ...

1. A handle assembly of a surgical instrument, the handle assembly comprising:an outer housing shell defining a cavity;
an instrument module selectively insertable into the cavity of the outer housing shell and including:
an inner housing shell defining a cavity therein; and
a motor disposed within the cavity of the inner housing shell;
wherein the inner housing shell and the outer housing shell are configured such that a driving force of the motor is communicated through each of the inner housing shell and the outer housing shell when the motor is contained within the inner housing shell and when the instrument module is contained within the outer housing shell.

US Pat. No. 10,426,493

PATIENT-SPECIFIC GLENOID GUIDES

Biomet Manufacturing, LLC...

1. A system for a shoulder joint of a patient comprising: a glenoid guide comprising:an upper surface;
a lower surface that is shaped as a patient-specific surface that is configured as a negative surface of at least a portion of a glenoid face based on a three-dimensional image of a shoulder joint of a patient reconstructed preoperatively from image scans of the shoulder joint of the patient;
a first drill guide extending from the upper surface along a first alignment axis configured preoperatively with a patient-specific orientation and insertion location for guiding a first glenoid implant into the glenoid face;
a second drill guide extending from the upper surface along a second alignment axis configured preoperatively with a patient-specific orientation and location for guiding a second glenoid implant into the glenoid face;
a baseplate implant configured to engage the glenoid face and having a plurality of fixation holes therein; and
a finishing drill guide configured to couple with the baseplate implant, the second drill guide including a plurality of drilling bores that communicate with the fixation holes.

US Pat. No. 10,426,491

TANGENTIAL FIT OF PATIENT-SPECIFIC GUIDES

Biomet Manufacturing, LLC...

1. A bone preparation guide comprising:a first patient-specific portion based on image data of a specific patient's bone and configured to match a bone surface on the specific patient;
a first bone-contacting portion based on image data of the specific patient's bone and configured to match the bone surface; and
an intermediate portion configured to be a bone-facing portion supported by the first patient-specific portion and the first bone-contacting portion;
wherein the bone contacting portion includes bone contacting members including pointed tips.

US Pat. No. 10,426,490

TRANSPARENT PRESSURE DRESSING DEVICE AND METHODS FOR ENABLING HEMOSTASIS OF BLOOD

1. A transparent pressure dressing device configured to enable hemostasis of blood in a perforation of a blood vessel, the transparent pressure dressing device comprising;a rectangular plate shaped artificial hand component, wherein the artificial hand component comprises a protuberance section positioned proximal to a distal edge of the artificial hand component; and
one or more adhesive fins extending from an upper surface of the artificial hand component, wherein the protuberance section of the artificial hand component is configured to be gradually pressed against the perforation on the blood vessel to enable hemostasis of the blood, and the adhesive fins are configured to adhere to a body surface of a patient proximal to the perforation on the blood vessel; and
further comprising one or more metal weight components positioned above and conforming to the upper surface of the artificial hand component, wherein each metal weight component is configured to add weight to the artificial hand component to increase the pressure applied to enable hemostasis of the blood at the perforation of the blood vessel; and
further comprising a plurality of magnetic pieces positioned on an upper surface of each metal weight component, wherein the magnetic pieces allow attachment of the one or more metal weight components above the artificial hand component to generate required compression on body's tissues proximal to the perforation of the blood vessel.

US Pat. No. 10,426,480

CUTTING RING ASSEMBLY WITH RIGID CUTTING MEMBER

Covidien LP, Mansfield, ...

1. An anvil assembly comprising:an anvil center rod;
an anvil head supporting an anvil plate having a plurality of staple deforming pockets; and
a cut ring assembly supported within the anvil head adjacent the anvil plate, the cut ring assembly including a backup member, an intermediate member and a cutting ring body, the backup member formed of a single integral material, wherein the intermediate member is formed of a thin, rigid material and is sandwiched directly between the backup member and the cutting ring body, wherein the intermediate member is in direct contact with the backup member and the cutting ring body, the thin, rigid material being formed of a material having a hardness less than the hardness of the backup member and greater than the hardness of the cutting ring body.

US Pat. No. 10,426,477

STAPLE CARTRIDGE ASSEMBLY INCLUDING A RAMP

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly, comprising:a cartridge body comprising a proximal end and a distal end;
a deck;
a longitudinal row of staple cavities defined in said deck;
a plurality of staples removably stored in said row of staple cavities, wherein each said staple comprises:
a base comprising a groove;
a first leg extending from said base; and
a second leg extending from said base; and
a ramp configured to move from said proximal end toward said distal end to eject said staples from said staple cavities, wherein said ramp travels along a path aligned with said bases of said staples, wherein said first legs are positioned on a first side of said path, wherein said second legs are positioned on a second side of said path, and wherein said groove of said base is configured to receive said ramp as said ramp travels along said path.

US Pat. No. 10,426,476

CIRCULAR FASTENER CARTRIDGES FOR APPLYING RADIALLY EXPANDABLE FASTENER LINES

Ethicon LLC, Guaynabo, P...

1. A fastener cartridge assembly for use with a circular surgical fastening device comprising a circular knife and an anvil, wherein the fastener cartridge assembly comprises:a cartridge body comprising a circular deck, wherein said circular deck comprises an inner edge, wherein said inner edge comprises an inner circular axis having an inner radius, and wherein said circular knife is configured to cut tissue clamped between said circular deck and the anvil along a circular knife path having a knife radius that is less than said inner radius;
a plurality of transverse fastener cavities opening through the circular deck in a transverse cavity zone, wherein each said transverse fastener cavity comprises two cavity ends, wherein one said cavity end of each of the transverse fastener cavities is positioned on a first circular axis having a first radius, and wherein the other said cavity end of each said transverse fastener cavity is positioned on a second circular axis that has a second radius that differs from the first radius;
a plurality of circumferential fastener cavities opening through the circular deck, wherein each of the circumferential fastener cavities are aligned on a third circular axis that comprises a third radius that differs from the first and second radiuses, and wherein the circumferential fastener cavities are not positioned in said transverse cavity zone; and
a plurality of fasteners removably positioned within said fastener cavities, wherein said plurality of fasteners are configured to be ejected from said fastener cavities simultaneously, and wherein said plurality of fasteners comprises:
a plurality of first fasteners comprising a first formed height; and
a plurality of second fasteners comprising a second formed height, wherein said first formed height and said second formed height are different,
wherein said third radius is greater than said inner radius, and
wherein said first radius and said second radius are greater than said third radius.

US Pat. No. 10,426,473

SYSTEM AND METHOD FOR PLICATING A HEART VALVE

Abbott Cardiovascular Sys...

1. A device for connecting together two opposing leaflets of a valve in a patient's heart, comprising:a first clip having a generally U-shape, comprising a first prong and a second prong, and a first bridge connecting the first prong to the second prong;
a second clip having a generally U-shape, comprising a third prong and a fourth prong, and a second bridge connecting the third prong to the fourth prong;
a third clip having a generally U-shape, comprising a fifth prong and a sixth prong, and a third bridge connecting the fifth prong to the sixth prong;
wherein the third prong has a first elongate axis and the fifth prong has a second elongate axis and the third prong and the fifth prong are positioned to extend adjacent to and parallel with the first prong, and are configured to rotate about the first elongate axis and the second elongate axis respectively.

US Pat. No. 10,426,472

DEVICES, SYSTEMS, AND METHODS FOR WOUND CLOSURE

Covidien LP, Mansfield, ...

1. A suture grasper for retrieving a suture from an internal surgical site, the suture grasper comprising:a housing;
an inner shaft extending from the housing and fixed relative thereto, the inner shaft having a tissue-penetrating tip;
an intermediate shaft disposed about the inner shaft, the intermediate shaft extending through a distal opening of an outer shaft and having a plurality of spring fingers movable between a spread position, wherein the spring fingers extend radially outwardly from the inner shaft and surround the inner shaft, and a compressed position, wherein the spring fingers are approximated about the inner shaft; and
the outer shaft disposed about the intermediate shaft and selectively translatable relative to the inner shaft and the intermediate shaft for moving the spring fingers between the spread position and the compressed position, wherein the intermediate shaft is translatable relative to the inner shaft and the outer shaft between a first proximal position, in which free ends of the spring fingers are positioned proximally of a distal region of the inner shaft, and a first distal position, in which the free ends of the spring fingers collectively enclose therein the tissue-penetrating tip of the inner shaft.

US Pat. No. 10,426,471

SURGICAL INSTRUMENT WITH MULTIPLE FAILURE RESPONSE MODES

Ethicon LLC, Guaynabo, P...

22. A powered surgical instrument, comprising:an end effector, comprising:
an actuation member movable through a firing stroke to actuate said end effector; and
a motor operably coupled to said actuation member, wherein said motor is configured to generate at least one rotational motion to move said actuation member through said firing stroke; and
a failure response system, comprising:
a first circuit configured to detect a first operational error of said powered surgical instrument, wherein said first operational error comprises detecting said movement of said firing member and said rotational motion of said motor exceeding a predetermined correlation during said firing stroke;
a second circuit configured to detect a second operational error of said powered surgical instrument, wherein said second operational error comprises detecting failure of at least one of a beginning-of-stroke switch and an end-of-stroke switch; and
a controller, comprising:
a memory;
a processor; and
a storage medium comprising program instructions which, when executed by said processor, cause said processor to:
activate a first failure response mode in response to the detection of said first operational error;
activate a second failure response mode in response to the detection of the first operational error and the second operational error, wherein said first failure response mode and said second failure response mode are different.

US Pat. No. 10,426,469

SURGICAL INSTRUMENT COMPRISING A PRIMARY FIRING LOCKOUT AND A SECONDARY FIRING LOCKOUT

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:a shaft comprising a longitudinal axis;
a firing drive comprising a firing member movable along said longitudinal axis;
an end effector, comprising:
a distal end;
a channel configured to receive a staple cartridge;
an anvil; and
a primary lockout configured to block said firing member from being moved toward said distal end if a staple cartridge is not positioned in said channel; and
a secondary lockout actuatable to prevent said firing member from being moved toward said distal end, wherein said secondary lockout is actuated in response to the distal movement of said firing member being blocked by said primary lockout.

US Pat. No. 10,426,468

HANDHELD ELECTROMECHANICAL SURGICAL SYSTEM

Covidien LP, Mansfield, ...

1. A handheld electromechanical surgical device, comprising:a non-sterile power-pack including:
at least one drive component, each drive component having a rotatable drive shaft extending therefrom;
a main processor coupled to the at least one drive component and configured to control each drive component;
a battery coupled to the main processor and the at least one drive component, the battery configured to power each drive component;
an electrical receptacle coupled to the main processor; and
at least one control interface coupled to the main processor, the at least one control interface actuatable to direct the main processor to control a functionality of at least one of the at least one drive component; and
a sterile outer shell housing configured to removably encase the power-pack, the sterile outer shell housing defining a sterile barrier between the power-pack and an exterior of the outer shell housing when encased about the power-pack to enable use thereof in a surgical environment without breaking sterility, the outer shell housing including:
a barrier plate assembly including:
a coupler configured to transmit a rotation from the rotatable drive shaft of each drive component through the outer shell housing, wherein the coupler includes a plurality of rotatable coupling shafts, each rotatable coupling shaft including a proximal end configured to operably couple to a respective rotatable drive shaft to receive rotative forces therefrom, and a distal end projecting from the outer shell housing;
at least one control button in operative registration with each of the at least one control interfaces such that actuation of the at least one control button actuates the at least one control interface in operative registration therewith; and
a pass-through connector configured to transmit electrical communications from the electrical receptacle through the outer shell housing, wherein the pass-through connector includes a proximal end configured to operably couple to the electrical receptacle, and a distal end projecting out of the outer shell housing.

US Pat. No. 10,426,467

SURGICAL INSTRUMENT WITH DETECTION SENSORS

Ethicon LLC, Guaynabo, P...

1. A surgical instrument comprising:a handle assembly;
a shaft coupled to the handle assembly;
an end effector communicatively coupled to the handle assembly through the shaft and comprising a first and second jaw, the handle assembly configured to manipulate the first and second jaws to define an open position and a closed position; and
a sensor apparatus integrally coupled to a distal end of the shaft comprising at least one sensor configured to transmit sensor signals onto patient tissue at a surgical site to directly measure a characteristic of the patient tissue and at least one receiver configured to receive sensor data of the patient tissue based on the transmission of the sensor signals.

US Pat. No. 10,426,466

HANDHELD ELECTROMECHANICAL SURGICAL SYSTEM

Covidien LP, Mansfield, ...

1. An adapter assembly, comprising:an elongate body including a proximal portion configured to couple to a handle assembly and a distal portion configured to couple to a surgical loading unit;
a switch actuator disposed within the elongate body and being movable between a proximal position, in which the switch actuator actuates a switch, and a distal position;
an actuation bar disposed within the elongate body and being movable between a proximal position and a distal position; and
a latch associated with the switch actuator and the actuation bar, the latch being movable between a first position, in which the latch permits proximal movement of the switch actuator, and a second position, in which the latch prevents proximal movement of the switch actuator, wherein the latch is configured to move from the first position toward the second position in response to the actuation bar moving toward the proximal position.

US Pat. No. 10,426,462

SIDE LOADING KNOT CUTTER

1. An instrument for securing a knot disposed in surgical suture, the instrument comprising:a shaft comprising:
a cannula having a proximal portion coupled to a handle and a distal portion including a distal end, the cannula extending parallel with a longitudinal axis of the handle, the cannula extending through a distal end of the handle to define a cannulated tip of the shaft; and
a cutting sleeve movably disposed over the cannula and configured to slide over the cannula;
a side-loading channel disposed along a side of the distal portion of the cannula and extending through the distal end of the cannula; and
a user manipulable control portion slidably mounted on an upper surface of the handle, the user manipulable control portion configured for controlling axial movement of the cutting sleeve along the cannula;
wherein the distal end of the cannula comprises a knot pushing surface,
wherein the side-loading channel is configured to receive a suture, and
wherein the cannulated tip is configured for receiving the suture from the side-loading channel.

US Pat. No. 10,426,461

SURGICAL ACCESS DEVICES HAVING A VARIABLE TISSUE APPROACH ANGLE

Ethicon LLC, Guaynabo, P...

1. A surgical access device, comprising:(a) a housing having a top surface, a side surface, and a tapered distal end;
(b) a cannula extending distally from the tapered distal end of the housing, wherein the cannula includes a cylindrical sidewall and an elongate opening disposed in the cylindrical sidewall, wherein the housing and the cannula define a working channel extending therethrough that is sized and configured to receive a surgical instrument;
(c) a cylindrical sleeve that encircles the cylindrical sidewall of the cannula, wherein the cylindrical sleeve overlies the elongate opening;
(d) a seal disposed within the working channel and configured to seal the working channel when no instrument is disposed therethrough; and
(e) a first suture channel, wherein the first suture channel extends through the side surface of the housing, passes directly from the housing to the cannula, extends across the working channel, and extends through the elongate opening and the cylindrical sleeve,
wherein the first suture channel extends at an oblique angle with respect to a central longitudinal axis extending through the cannula, wherein the oblique angle is selectively adjustable.

US Pat. No. 10,426,454

ORTHOPEDIC TOOLS FOR IMPLANTATION

GLOBUS MEDICAL, INC., Au...

1. An orthopedic system comprising:a first bone pin, wherein the first bone pin comprises a lower threaded portion and an upper threaded portion;
a first wide blocking blade delivered over the first bone pin, wherein the first wide blocking blade comprises at least two blocking panels;
a first distraction blade delivered over the first bone pin, wherein the first distraction blade includes a slot for receiving the first bone pin therein;
a second bone pin, wherein the second bone pin comprises a lower threaded portion and an upper threaded portion;
a second wide blocking blade delivered over the second bone pin, wherein the second wide blocking blade comprises at least two blocking panels;
a second distraction blade delivered over the second bone pin, wherein the second distraction blade includes a slot for receiving the second bone pin therein; and
a frame attached to at least one of either: (i) the first distraction blade and the second distraction blade or (ii) the first wide blocking blade and the second wide blocking blade,
wherein the first wide blocking blade comprises a first bone pin receiver configured to directly and slidably receive the first bone pin,
wherein the first bone pin receiver is configured such that the first wide blocking blade does not rotate once the first bone pin receiver is deposited on the first bone pin,
wherein the first distraction blade comprises a ring element to engage the first bone pin, and
wherein the first bone pin includes a non-threaded shelf portion disposed in the middle of the first bone pin and extending radially around the first bone pin, the shelf portion having a diameter that is larger than a diameter of the first bone pin.

US Pat. No. 10,426,450

RETRACTOR

Spinal Elements, Inc., C...

1. A retractor comprising:a first blade,
a first rotation mechanism that rotates the first blade about a first axis,
a second blade,
a second rotation mechanism that rotates the second blade about a second axis,
a first pivot mechanism that pivots the first blade about a fourth axis, wherein the fourth axis is skewed to the first axis;
a second pivot mechanism that pivots the second blade about a fifth axis, wherein the fifth axis is skewed to the second axis;
an actuator that translates the first blade and second blade about a third axis; and
a slide mechanism that slides the first blade and second blade along a sixth axis.

US Pat. No. 10,426,449

ARTICULATING SUTURING DEVICE WITH IMPROVED ACTUATION AND ALIGNMENT MECHANISMS

Abbott Cardiovascular Sys...

1. An improved actuation and control mechanism intended for use in a vessel closure device for closing an opening or puncture in a vessel wall having an elongate shaft having a longitudinal axis, a housing positioned at the proximal end of the shaft, a flexible, atraumatic monorail guidebody positioned at the distal end of the shaft, a foot articulatably mounted proximate the distal end of the shaft, the foot being movable between a first, parked position, in which the foot is substantially aligned along the axis of the shaft, and a second, deployed position, in which the foot extends laterally away from the shaft, the foot having a first and a second end, the first end and the second end each having a needle receptacle with a cuff positioned therein, a length of suture located within the foot and extending between the cuffs, and a pair of needles located within the shaft that can be selectively advanced through the vessel wall adjacent to the opening and into the cuffs located in the needle receptacles in the first and second ends of the foot, and that can be selectively withdrawn thereby drawing the suture through the vessel wall adjacent to the opening, the improved actuation and control mechanism for the vessel closure device comprising:a foot actuation handle operatively coupled to the foot, the foot actuation handle being selectively moveable linearly along the axis of the device between a distal position whereby the foot is positioned in its first, parked position, and a proximal position whereby the foot is positioned in its second, deployed position, the foot actuation handle comprising a pair of handles that extend laterally from opposing sides of the housing, and wherein the foot actuation handle is configured to be grasped and manipulated by a pair of fingers of one hand of a user; and
a needle actuation handle operatively coupled to the needles, the needle actuation handle being selectively movably linearly along the axis of the device between a proximal position wherein the needles are located within the shaft and a distal position wherein the needles are advanced to engage the cuffs, and wherein the needle actuation handle is configured to be engaged and selectively manipulated by a thumb of the same one hand of the user.

US Pat. No. 10,426,438

ULTRASOUND APPARATUS AND METHOD OF MEASURING ULTRASOUND IMAGE

SAMSUNG MEDISON CO., LTD....

1. A method of measuring an ultrasound image in an ultrasound apparatus, comprising:displaying an ultrasound image on a screen;
receiving, by a user input interface, a first user input of selecting at least two first coordinates on the ultrasound image;
determining, based on a match of the first user input to a first one of stored user inputs in a memory of the ultrasound apparatus determined by a processor of the ultrasound apparatus, a first measurement tool;
activating, by the processor, the first measurement tool corresponding to the first matched user input;
acquiring first measurement information on the ultrasound image by using the first measurement tool;
receiving, by the user input interface, a second user input of selecting at least one second coordinate on the ultrasound image;
determining, based on a match of the second user input to a second one of the stored user inputs determined by the processor, a second measurement tool;
switching from the first measurement tool corresponding to the first matched user input to the second measurement tool corresponding to the second matched user input, the second measurement tool being displayed on the ultrasound image; and
acquiring second measurement information on the ultrasound image by using the second measurement tool,
wherein the first measurement information and the second measurement information are different kinds of information.

US Pat. No. 10,426,412

METHODS AND APPARATUS FOR DISPLAYING THREE-DIMENSIONAL ORIENTATION OF A STEERABLE DISTAL TIP OF AN ENDOSCOPE

INTUITIVE SURGICAL OPERAT...

1. A method for graphically visualizing an orientation of a steerable distal portion of an elongate instrument, said instrument comprising at least one tensioning member attached to said steerable distal portion, said method comprising:actuating said at least one tensioning member to result in an approximate y-bend and an approximate x-bend of said steerable distal portion, wherein said approximate y-bend and said approximate x-bend define an approximate overall bend of said steerable distal portion; and
displaying on a graphical user interface an icon representing a magnitude and a direction of the approximate overall bend of said steerable distal portion,
wherein:
an origin is defined on the graphical user interface;
a distance between the icon and the origin corresponds to the magnitude of the approximate overall bend; and
an orientation of the icon with reference to the origin corresponds to the direction of the approximate overall bend.

US Pat. No. 10,426,411

SYSTEM AND METHOD FOR PROVIDING A REAL-TIME SIGNAL SEGMENTATION AND FIDUCIAL POINTS ALIGNMENT FRAMEWORK

Samsung Electronics Co., ...

1. A method comprising:determining a signal type for a first signal received via at least one channel from a user;
monitoring motion of the user, wherein when the monitored motion is below a pre-determined threshold:
providing a second signal from the first signal;
segmenting the second signal to form a first signal segment and a second signal segment;
processing, based on the signal type, the first signal segment and the second signal segment to determine a fiducial point for each of the first signal segment and the second signal segment,
wherein
when the signal type of the first signal is determined to be a ballistocardiography (BCG) signal:
determining a first event location from the first signal segment and identifying the first event location as the fiducial point for the first signal segment,
matching one or more adjacent points from the second signal segment to the fiducial point for the first signal segment,
selecting one of the one or more adjacent points as a fiducial point for the second signal segment corresponding to the fiducial point for the first signal segment, and
generating a third signal using the fiducial points.

US Pat. No. 10,426,406

DETECTING AND SUPPRESSING NOISE SIGNALS OF A DIFFERENTIAL VOLTAGE MEASURING SYSTEM

Siemens Healthcare GmbH, ...

1. A method for detecting noise signals of a differential voltage measuring system for measuring cardiac movements in a patient, the method comprising:contacting the patient with at least two measuring electrodes having at least one associated measuring channel;
performing a learning procedure comprising detecting learning signals from the patient over the at least one measuring channel, identifying at least one heartbeat type based on the detected learning signals, and storing the at least one heartbeat type;
performing a heartbeat measurement following the performing of the learning procedure;
detecting, during the heartbeat measurement, signals from the patient over the at least one measuring channel; and
checking whether a detected signal of the detected signals from the heartbeat measurement has been caused by noise by comparing the detected signal with the at least one stored heartbeat type identified in a course of the learning procedure, wherein the detected signal is classified as noise when the detected signal does not correspond to any stored heartbeat type of the at least one stored heartbeat type.

US Pat. No. 10,426,404

SENSOR JACKET

ST. JUDE MEDICAL COORDINA...

1. A sensor guide wire for intravascular measurement of a physiological variable, comprising:a core wire extending at least partly along a length of the sensor guide wire;
a sensor element mounted on the core wire, in a sensor region of the sensor guide wire, the sensor element comprising a pressure sensitive device;
a jacket having a jacket wall, the jacket being fixed relative to the core wire; and
at least one lead connected to the sensor element;
wherein the jacket is tubular and includes a proximal end opening, a distal end opening, and a first set of openings extending through the jacket wall,
wherein the core wire extends through the jacket via the proximal and distal end openings, and
wherein the first set of openings extending through the jacket wall includes a first opening located above the sensor element, a second opening located at a first lateral side of the sensor element, and a third opening located at a second lateral side of the sensor element, and wherein the first, second, and third openings are elongated in a longitudinal direction of the jacket, and are aligned in a circumferential direction of the jacket.

US Pat. No. 10,426,377

DETERMINING A LOCATION OF A MEMBER

Medtronic, Inc., Minneap...

1. A method to locate and determine a position of portions of an instrument in a volume, comprising:providing an elongated and flexible member extending between a first end and a second terminal end with a first position element having a plurality of first position element portions positioned near the first end and between the first end and the second terminal end and a second position element positioned near the second terminal end;
positioning a set of axis generation electrodes on a surface of the volume;
injecting a current into the volume between the set of axis generation electrodes;
sensing with the first position element and the second position element an electrical property due to the injected current into the volume between the set of axis generation electrodes;
evaluating the sensed electrical property sensed with the first position element and the second position element;
determining a relative position of the first position element and the second position element based on the evaluation of the electrical property;
determining a non-linear geometry of the elongated and flexible member based on the determined relative position of the first position element having the plurality of first position element portions and the second position element; and
determining an amount of lead slack of the elongated and flexible member within the volume based on the determined non-linear geometry.

US Pat. No. 10,426,374

METHODS FOR BIOMEDICAL TARGETING AND DELIVERY AND DEVICES AND SYSTEMS FOR PRACTICING THE SAME

The Regents of the Univer...

1. A trajectory guide for magnetic resonance imaging (MRI)-assisted targeting of a desired area of a subject, comprising:a solid support comprising a flat surface; and
a plurality of MRI-visible styles each comprising a lumen comprising a contrast agent, wherein each MRI-visible style of the plurality is affixed at one end to the flat surface and dimensioned for insertion into each channel of an adjustable turret comprising a plurality of channels, the adjustable turret affixed to a tissue surface of a subject thereby allowing targeting of each channel by visualizing the trajectory of each inserted MRI-visible style using an MRI imager.

US Pat. No. 10,426,372

IMAGE REGISTRATION SYSTEM WITH NON-RIGID REGISTRATION AND METHOD OF OPERATION THEREOF

Sony Corporation, Tokyo ...

1. A method of operation of an image registration system comprising:obtaining a pre-operation non-invasive imaging volume with an imaging unit;
generating a volume image based on the pre-operation non-invasive imaging volume;
obtaining an intra-operation non-invasive imaging volume with the imaging unit;
isolating a region of interest from the intra-operation non-invasive imaging volume;
determining feature points of the region of interest;
matching the feature points with corresponding points of the volume image for generating a matched point cloud;
generating a non-rigid registered volume based on the matched point cloud for display on a display interface, wherein a type of pre-operation non-invasive imaging volume and a type of intra-operation non-invasive imaging volume are tailored to a type of image-guided surgery performed, wherein generating the non-rigid registered volume includes using the matched point cloud as an input to a radial basis function to reconstruct volume data, wherein matching the feature points with the corresponding points of the volume image includes:
using the volume image as a reference map for matching the region of interest to anatomical features of the volume image;
determining a maximum displacement distance between the feature points and the corresponding points; and
restricting a search space for the corresponding points to be within the maximum displacement distance from the feature points.

US Pat. No. 10,426,368

METHOD AND SYSTEM FOR CARDIAC ISCHEMIA DETECTION

KONINKLIJKE PHILIPS N.V.,...

1. An electronic patient monitoring device comprising:an electrocardiograph system configured to acquire electrocardiographic data for a set of electrocardiograph leads;
a display device;
an electronic data processing device configured to:
compute ST values from the electrocardiographic data;
generate and display, on the display device, an ST Map plotting the ST values;
superimpose, on the ST Map displayed on the display device, a rendering of an ischemia criteria area representing an ischemic criteria, wherein the ischemia criteria includes thresholds for leads of the set of electrocardiographic leads and the ischemia criteria area is bounded by the thresholds and extends radially outward from the thresholds;
determine whether ST values of the ST Map satisfy the ischemia criteria; and
conditional on the ST values of the ST Map satisfying the ischemia criteria, compute an overlap between (1) an ST area delineated by the ST values of the ST Map and (2) the ischemia criteria area and highlight the overlap on the ST Map displayed on the display device.

US Pat. No. 10,426,362

DEEP-BRAIN PROBE AND METHOD FOR RECORDING AND STIMULATING BRAIN ACTIVITY

The Board of Trustees of ...

1. A deep-brain probe comprising:(A) a wire bundle comprising a first plurality of wires that are arranged in a first two-dimensional arrangement, wherein each of the first plurality of wires has a first end and a second end, and wherein each of the first plurality of wires includes:
a core that is electrically conductive;
an electrical insulator that surrounds the core along the length of the wire; and
an electrode that is electrical-insulator-free;
wherein the wire bundle has a first portion in which the first plurality of wires is mechanically joined together to collectively define a stalk, the first end of each wire of the plurality thereof terminating at a first surface of the stalk; and
wherein the wire bundle has a second portion in which each wire of the first plurality thereof is unrestrained, the second end and the electrode of each wire of the plurality thereof being in the second portion;
(B) a first integrated circuit comprising a plurality of bond pads that is arranged in a second two-dimensional arrangement; and
(C) an interposer that includes:
(i) a body having a first surface and a second surface, the body comprising a first material that is an electrical insulator, and the body being compressible, wherein the body includes;
(a) a first layer comprising the first material, the first material being characterized by a first modulus of elasticity;
(b) a second layer that includes the first surface; and
(c) a third layer that includes the second surface, the second and third layers comprising a third material having a second modulus of elasticity that is higher than the first modulus of elasticity;
wherein the first layer is between the second and third layers; and
(ii) a plurality of conductors that extend through the body from the first surface to the second surface, wherein each of the plurality of conductors comprises a second material that is electrically conductive;
wherein the wire bundle, first integrated circuit, and interposer are arranged such that each of the plurality of bond pads is electrically connected with each of one or more wires of the first plurality thereof via at least one of the plurality of conductors.

US Pat. No. 10,426,357

BODY-WORN SENSOR FOR CHARACTERIZING PATIENTS WITH HEART FAILURE

TOSENSE, INC., La Jolla,...

1. A sensor for measuring both impedance and ECG waveforms and configured to be worn on a patient's torso, comprising:(i) a first electrode region comprising at least first and second electrodes and a backing supporting the at least first and second electrodes; and
a second electrode region comprising at least third and fourth electrodes and a backing supporting the at least third and fourth electrodes,
wherein the first and second electrode regions are configured to be spatially separate and positioned on opposite sides of the medial axis of the patient's chest at approximately shoulder level below the collarbone;
(ii) a flexible electronics module comprising:
a digital processing system comprising a microprocessor and an analog-to-digital converter and a wireless transceiver;
a first sensor module configured to reversibly mate to the first electrode region and to electrically connect the first and second electrodes to the electronics module via a first conductor segment, and to operably connect a first electrical connector to the electronics module via a second conductor segment;
a second sensor module configured to reversibly mate to the second electrode region and to electrically connect the third and fourth electrodes to the electronics module via a third conductor segment, and to operably connect a second electrical connector to the electronics module via a fourth conductor segment; and
a battery module configured to reversibly mate to the first electrical connector and to the second electrical connector to electrically connect the battery module to the electronics module,
wherein
the electronics module, the first sensor module, the second sensor module, the first conductor segment, the second conductor segment, the third conductor segment, the fourth conductor segment, the first electrical connector, and the second electrical connector are of unitary construction;
the electronics module, the battery module, the first sensor module, and the second sensor module form an analog ECG circuit when the first sensor module is in electrical contact with the first electrode and the second sensor module is in electrical contact with the third electrode, the ECG circuit configured to generate an analog ECG waveform;
the electronics module, the battery module, the first sensor module, and the second sensor module form an analog impedance circuit when the first sensor module is in electrical contact with the first and second electrodes and the second sensor module is in electrical contact with the third and fourth electrodes, the impedance circuit configured to generate an analog impedance waveform; and
the digital processing system is configured to receive and process the analog ECG and impedance waveforms and to generate therefrom digital ECG and impedance waveforms, to determine therefrom on a continuous basis a heart rate (HR) value and a blood pressure (BP) value for the patient, and to transmit the HR and BP values to an external computer, and
further comprising a flash memory system.

US Pat. No. 10,426,342

REMOTE ACCESS FOR AMBULATORY MEDICAL DEVICE

ZOLL Medical Corporation,...

1. An external ambulatory medical device comprising:an electrocardiogram (ECG) sensor configured
to couple to a skin of a patient, and
to monitor an ECG signal of the patient over an extended period of time;
a controller operatively coupled to the ECG sensor and configured to monitor the ECG signal over the extended period of time;
at least one therapy electrode operatively coupled to the controller and configured to deliver at least one therapeutic defibrillating shock to the patient; and
a remote access manager operatively coupled to the controller and configured
to monitor for a command to communicate with a remote system,
to establish a communication session with the remote system in response to the command for communication between the external ambulatory medical device and the remote system in real time or substantially in real time, and
to cause the controller to reconfigure one or more response buttons of the controller to perform a different operational function in response to detecting an anomalous condition of the one or more response buttons based on information received via the communication session.

US Pat. No. 10,426,341

SYSTEMS AND METHODS FOR SENSING INTRAOCULAR PRESSURE

CALIFORNIA INSTITUTE OF T...

1. A system for sensing biological pressure, comprising:an implantable device comprising a first membrane structure, a second membrane structure, and a plurality of nanophotonic components adapted to reflect light, wherein the first and second membrane structures are separated by a gap and the first membrane structure is movable with respect to the second membrane structure in response to a change in ambient pressure such that the implantable device has a resonance wavelength that shifts as a size of the gap changes; and
a reader unit adapted to transmit optical light to the implantable device and detect the resonance wavelength of the implantable device based on light reflected from the implantable device.

US Pat. No. 10,426,339

APPARATUSES AND METHODS FOR PARAMETER ADJUSTMENT IN SURGICAL PROCEDURES

Novartis AG, (CH)

1. An ophthalmic surgical system, comprising:a surgical microscope operable to provide a field of view of a surgical site to a user;
a display device in communication with the surgical microscope, the display device operable to output a graphical overlay into the field of view of the surgical microscope;
a surgical tool configured to be inserted into a patient and operable to perform a surgical task at the surgical site while the user visualizes the field of view using the surgical microscope, wherein the graphical overlay displays one or more configurable parameters that modify operation of the surgical tool;
an input device operable to receive user input from the user to adjust the one or more configurable parameters associated with the surgical tool, the user input entered using the graphical overlay while the user visualizes the field of view using the surgical microscope; and
a computing device operable to:
generate a control signal to adjust the one or more configurable parameters that modify the operation of the surgical tool in the response to the user input entered using the graphical overlay; and
output the control signal to the surgical tool to control the surgical tool to perform the surgical task at the surgical site according to the user input entered using the graphical overlay.

US Pat. No. 10,426,322

IMAGE RECORDING APPARATUS

OLYMPUS CORPORATION, Tok...

1. An image recording apparatus comprising:a first processing section that encodes an inputted medical image based on setting information including encode processing information and outputs a first encode result, the setting information being set for each medical case scene of a plurality of medical case scenes:
a second processing section that encodes the inputted medical image based on the setting information including the encode processing information and outputs a second encode result;
a setting section that stores the setting information to designate an encode method for each of the first processing section and the second processing section, and storage destination information indicating (i) a recording destination of the first encode result and the second encode result and (ii) an image quality associated with each of the first encode result and the second encode result; and
a control section configured to:
receive a scene selection signal corresponding to a selection of one of the plurality of medical case scenes that respectively correspond to different states of progresses of medical treatments,
upon receiving the scene selection signal, read and determine the setting information corresponding to the selected one medical case scene of the plurality of medical case scenes in the scene selection signal,
based on storage destination information included in the read setting information, control the first processing section and the second processing section to encode and output at least one of the first encode result and the second encode result, the control causing: (i) the first processing section to always encode and output the first encode result, and (ii) whether the second processing section encodes and outputs the second encode result based on the encoding method and the image quality of the read setting information, and
automatically determine a recording destination of the output at least one of the first encode result and the second encode result based on the storage destination information corresponding to the scene selection signal, wherein
the setting information is stored in a memory different from recording destinations of the first encode result and the second encode result.

US Pat. No. 10,426,315

DISHWASHER

Whirlpool Corporation, B...

1. A dishrack for a dishwasher comprising:a non-wire-frame frame forming a lower periphery of the dishrack with a bounded interior opening and having an upper surface and a ledge located on an exterior of the non-wire-frame, below the upper surface, to form a seat;
at least one wire-frame insert having a peripheral wire-frame element removably resting on the ledge within the seat and a plurality of wire-frame cross-members spanning the peripheral wire-frame element;
wherein the at least one wire-frame insert overlies and functionally closes at least a portion of the bounded interior when the peripheral wire-frame element rests on the ledge;
wherein the peripheral wire-frame element has at least two spaced side elements and further comprises multiple, spaced wire-frame cross members spanning the spaced side elements; and
wherein the cross members comprise a first set with a first number of peaks and a second set with a second number of peaks, different than the first number.

US Pat. No. 10,426,310

VACUUM CLEANER

LG Electronics Inc., Seo...

1. A vacuum cleaner comprising:a cleaner body;
wheels provided at both side surfaces of the cleaner body, the wheels being configured to allow the vacuum cleaner to travel on ground and to allow the cleaner body to rotate about the wheels in forward and reverse directions;
a wheel motor assembly provided between an outer surface of the cleaner body and each of the wheels, the wheel motor assembly being configured to rotate at least one of the wheels;
a detecting part provided at the cleaner body and configured to detect an inclination of the cleaner body; and
a PCB configured to cause the wheel motor assembly to be driven according to the inclination of the cleaner body detected by the detecting part,
wherein the wheel motor assembly is positioned rearward of a vertical extension line of a rotating center of the wheels such that a center of gravity of the cleaner body is located closer to a rear end of the cleaner body than its front end, and
wherein the center of gravity of the cleaner body is located rearward of rotating centers of the wheels such that the cleaner body is configured, based on the vacuum cleaner being stationary, to be inclined toward the reverse direction.

US Pat. No. 10,426,306

BRUSHBAR, CLEANER HEAD AND METHOD OF MANUFACTURE OF A BRUSHBAR

Dyson Technology Limited,...

1. A brushbar for a cleaner head comprising:a brushbar body comprising a channel that extends in a longitudinal direction of the brushbar and at least one retaining lip provided along at least one side of the channel and spaced away from a bottom of the channel, the channel having a varying portion in which a depth of the channel decreases from one end of the varying portion in a longitudinal direction of the channel;
an agitator element comprising a flexible strip and an agitator, wherein the flexible strip comprises a fabric and has a maximum thickness of less than 1 mm, and wherein the flexible strip is disposed in the channel and extends between the at least one retaining lip and the bottom of the channel such that the at least one retaining lip retains the flexible strip in the channel and the agitator extends radially outwardly from the channel; and
a shim disposed between the flexible strip and the bottom of the channel such that the flexible strip is held in abutting contact with the at least one retaining lip, wherein the shim has a varying portion in which a thickness of the varying portion of the shim decreases in a longitudinal direction of the shim by an amount which corresponds to the decrease in the depth of the channel.

US Pat. No. 10,426,293

COLLAPSIBLE BARBEQUE

1. A collapsible barbeque comprising a generally rectangular frame which carries a trough and a number of leg assemblies which support the frame above a surface, wherein the trough is generally rectangular in shape and includes a rigid floor to provide a heat support surface and two collapsible sidewalls which connect the floor to the frame, the sidewalls and the leg assemblies being hingedly attached to the frame, and wherein the sidewalls include at least one hinge up a height thereof to allow the sidewalls to collapse inwardly in concertina fashion with the floor moving towards the frame and the sidewalls folding inwardly toward each other such that the collapsible barbeque is movable from an open, operative configuration in which the collapsible sidewalls are extended and the leg assemblies are hinged outwardly from the frame to a closed, portable configuration in which the collapsible sidewalls are collapsed and the leg assemblies are folded flat against the frame.

US Pat. No. 10,426,284

FABRIC TREATING SYSTEMS AND ACCESSORIES

Whirlpool Corporation, B...

1. A fabric treating system, comprising:an enclosure defining a fabric receiving space and comprising:
a first wall; and
a second wall;
a support member disposed within the enclosure and configured to support a piece of fabric within the fabric receiving space;
a fabric tensioning system disposed within the enclosure and comprising:
a first fabric grasper extendable from a bottom portion of the enclosure and attached to the piece of fabric and applying tension to the piece of fabric;
a second fabric grasper extendable from a bottom portion of the enclosure and attached to the piece of fabric and applying tension to the piece of fabric; and
one of a resilient member and an extendable member configured to bias the support member proximate to the first wall, wherein one of the resilient member and the extendable member is configured to permit relative movement of the support member with respect to the first wall and permit tensioning of the piece of fabric.

US Pat. No. 10,426,283

MULTI-POSITION SUIT HANGER SYSTEM AND METHOD

Charles Howard Karelis, ...

1. A multi-position hanger comprising:a hook member comprising a hook portion and a stem portion;
a wishbone rotatably attached to the stem portion of the hook member, the wishbone comprising a first arm that defines a first free end and an opposing second arm that defines a second free end; and
a pants bar comprising a first end portion rigidly attached to the wishbone and a second end portion positioned below the wishbone and defining a free end spaced from the wishbone,
wherein the pants bar is rotatable with respect to the stem portion of the hook member via the wishbone such that the pants bar is selectively reconfigurable between a kick out position with the second end portion of the pants bar positioned at a first lateral position with respect to a centerline extending vertically downward from the wishbone and a nested position with the second end portion of the pants bar positioned at a second lateral position with respect to the centerline, at least the first lateral position being laterally spaced from the centerline, and the first and second lateral positions being differing lateral positions with respect to the centerline,
wherein the wishbone is positioned fully below the hook portion of the hook member when the pants bar is in the kick out and nested positions, and
wherein the wishbone includes a first portion that engages and selectively retains the stem portion of the hook member when the pants bar is in the kick out position to selectively retain the pants bar in the kick out position.

US Pat. No. 10,426,254

SYSTEMS AND METHODS FOR PROVIDING ANGLE GUIDANCE FOR A USER OPERATING AN ORAL HYGIENE DEVICE

KONINKLIJKE PHILIPS N.V.,...

1. An oral hygiene device, comprising:a longitudinal shaft defining a longitudinal axis;
an attachment assembly located at a first end of the longitudinal shaft, the attachment assembly for contacting a contact surface in a user's mouth;
a handle portion comprising:
a portion of the longitudinal shaft comprising a second end of the longitudinal shaft;
a force sensor operable to detect an amount of side force applied to the attachment assembly, the side force comprising a force applied by the contact surface in a direction perpendicular to both the longitudinal axis and the normal of the contact surface, the force sensor comprising a suspension system having at least one elastic spring element and a predefined stiffness for motion in a first direction and a second direction, wherein the first and second direction are both perpendicular to the longitudinal axis of the longitudinal shaft;
at least one accelerometer operable to measure an amount of gravitational force applied to the attachment assembly; and
at least one processor operable to determine an angle that the attachment assembly is applied at based on the detected amount of side force.

US Pat. No. 10,426,239

RECEIVING DEVICE

Fu Tai Hua Industry (Shen...

1. A receiving device comprising:a casing comprising a baseboard, a first side plate, a second side plate, and a receiving member;
a guiding member received in the receiving member and defining a receiving groove used for receiving a rod-shaped object;
a rotation member rotatably covering the receiving groove and defining a bump element and a first spring, wherein the bump element is connected to the first side plate by the first spring;
a key movably arranged in the casing and having an exposed end protruding out from the casing; and
a pushrod comprising a first end contacting the key, a second end mounted on the bump element, and a spindle mounted on the casing;
wherein when the exposed end of the key is pressed, the key drives the pushrod to rotate about the spindle, and the pushrod drives the rotation member to rotate until the receiving groove is no longer covered, thus the receiving groove is made accessible.

US Pat. No. 10,426,231

MOLDED SURFACE FASTENER, CUSHION BODY, CUSHION BODY MANUFACTURING METHOD, AND MOLDING DIE

YKK Corporation, (JP)

1. A molded surface fastener that is configured to be integrated to a groove portion for fixing a skin material provided on a surface portion of a cushion body along a length direction of the groove portion at a time of foam molding of the cushion body,comprising at least one surface fastener portion in which an engaging region is formed of a plurality of hook-shaped engaging elements standing on a first surface of a flat plate-shaped substrate portion wherein:
a foldable piece portion extends from one of left and right end edge portions in a width direction which is perpendicular to the length direction of the surface fastener portion,
at least a part of the foldable piece portion has flexibility which is foldable with respect to the surface fastener portion,
the surface fastener portion has a pair of first barrier portions standing along a width direction at both end portions in a length direction of the substrate portion and between which the engaging region is disposed, and a second barrier portion standing along the length direction at an end edge portion of an opposite side of a side of the foldable piece portion in the substrate portion,
each hook-shaped engaging element has a rising portion standing from the substrate portion and a hook portion extending in the width direction from an upper end of the rising portion, and
the hook portion extends only toward a side of the foldable piece portion.

US Pat. No. 10,426,229

FOOTWEAR MANUFACTURING PROCESS

1. A method of manufacturing a shoe sole, the method comprising the steps:acquiring a plurality of tennis balls
grinding the tennis balls in a granulator, thereby generating felt fuzz and rubber granules;
passing said felt fuzz and rubber granules through a screen, thereby separating said rubber granules from said felt fuzz;
combining water and polyurethane, resulting in a water and polyurethane mixture;
combining said water and polyurethane mixture with said rubber granules;
mixing said rubber granules and said water and polyurethane mixture into a rubber mixture;
placing said rubber mixture into a hydraulic press;
pressing said rubber mixture into a sheet;
curing said sheet;
selecting a cut-out die, said cut-out die shaped for forming a footwear sole;
cutting a sole from said sheet with said cut-out die; and
applying said sole to a piece of footwear.

US Pat. No. 10,426,228

SHOELACE WITH MAGNETS

1. A shoelace comprising:a cord having two ends;
two aglets, one at each end of the cord; and
three or more magnets integrated within the shoelace, wherein the three or more magnets include a first magnet disposed at a first location within or adjacent to one of the two aglets, a second magnet disposed at a second location within or adjacent to the other of the two aglets, and a third magnet disposed at a centerpoint of the cord.

US Pat. No. 10,426,225

SHOE WITH A HIGH HEEL TO LOW HEEL CONVERSION

High-Low Heel, LLC, Vanc...

1. An article of footwear comprising:a sole including a heel receiver having a fixed hook portion, a movable hook portion disposed opposite the fixed hook portion, and an actuator configured to move the movable hook portion between a retracted position and an extended position, wherein the actuator and the movable hook portion are formed as a single piece and are guided and retained against a bottom of the sole by a pair of side guides and a retainer bar;
a first heel portion and a second heel portion, each of the first and second heel portions having a first recess configured to engage the fixed hook portion and a second recess configured to engage the movable hook portion, such that, when the respective heel portion is engaged with the heel receiver: (a) the respective heel portion is secured to the heel receiver when the movable hook portion is in the extended position, and (b) the respective heel portion is releasable from the heel receiver when the movable hook portion is in the retracted position;
wherein the article of footwear is transitionable between a first configuration, in which the first heel portion is secured to the heel receiver portion of the sole, and a second configuration, in which the second heel portion is secured to the heel receiver portion of the sole.

US Pat. No. 10,426,222

SOLE STRUCTURE FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A sole structure for an article of footwear, comprising:an upper element;
a lower element positioned below the upper element;
a first elongated, cantilevered flexure element extending from a base element, the base element constituting at least part of one of the upper element and the lower element; and
a second elongated, cantilevered flexure element joined to an opposed element, the opposed element being at least a part of the other of the upper element and the lower element, the second flexure element extending from the opposed element toward the base element,
wherein the first and second flexure elements have a first free end and a second free end respectively, and wherein the first flexure element is configured for slidingly contacting the opposed element when a vertical compressive load is applied to the upper element.

US Pat. No. 10,426,221

METHOD AND APPARATUS FOR DYNAMICALLY ALTERING A HEIGHT OF A SOLE ASSEMBLY

NIKE, Inc., Beaverton, O...

1. An actuator assembly for an article of footwear comprising:a wedge having an anterior end, a posterior end, and an inclined upper surface extending upwardly from the anterior end to the posterior end;
a retractor connected to a rear portion of the wedge and configured to pull the wedge rearwardly within a groove formed in a sole assembly of an article of footwear; and
a spring assembly connected to a front portion of the wedge and configured to provide tension in a forward direction on the wedge positioned in the groove.

US Pat. No. 10,426,217

FOOTWEAR WITH INTERCHANGEABLE SECTIONS

1. An article of footwear, comprising:a toe portion comprising:
a toe cover secured to a first end of an upper surface of a toe plate; and,
a plurality of prong receivers disposed in a first array across a majority of a width of said toe plate and along a second end of said toe plate;
a heel portion comprising:
a heel back secured to a first end of an upper surface of a heel plate;
a heel stem secured to a lower surface of said heel plate; and,
a plurality of prongs projecting away from said heel plate and disposed in a second array across a majority of a width of said heel plate and along a second end thereof; and,
a flap removably covering said upper surface of said toe plate and said heel plate and coextensive with a width of said toe plate and said heel plate;
wherein said plurality of prongs is capable of being removably secured within said plurality of receivers thereby securing said toe portion to said heel portion;
wherein each prong receiver comprises a square-shaped opening; and
wherein each prong comprises a lengthened pyramid having a sharp distal end.

US Pat. No. 10,426,215

HELMET WITH FACEMASK ADJUSTMENT MECHANISM

SPORT MASKA INC., Montre...

1. A protective helmet comprising:a helmet body having a front portion;
a facemask extending from the front portion to cover at least a portion of a face of a wearer;
at least one adjustment mechanism securing the facemask to the helmet body, the at least one adjustment mechanism including a base defining an aperture, the at least one adjustment mechanism connected to the helmet by a fastener received through the aperture and including an engagement member engaged with the facemask, the at least one adjustment mechanism being selectively engageable with the facemask in at least two vertically spaced apart positions of the facemask relative to the helmet body, the at least one adjustment mechanism allowing toolless adjustment between the at least two vertically spaced apart positions.

US Pat. No. 10,426,212

MODULAR FOOTBALL HELMET APPARATUS AND SYSTEM

1. A modular helmet comprising:a frame comprising a plurality of elongated ribs extending upward from a base portion, the plurality of elongated ribs defining a cranial portion, each elongated rib in the plurality of elongated ribs being spaced apart from each adjacent elongated rib in the plurality of elongated ribs such that each elongated rib in the plurality of elongated ribs is configured to independently flex upon an impact; and,
a shell being configured to be removably coupled to the frame, the shell being configured to house the frame in an interior portion of the shell.

US Pat. No. 10,426,209

PROCESS FOR CREATING TRANSITORY COLORED HAIR FOR HAIR EXTENSIONS AND WIG HAIR

1. A transitory colored hair for extensions or wigs having colors that segregate longitudinal hair strands into three horizontal sections and formed by combining a hair group 1 and a hair group 2 comprising:hair group 1 consists of hair strands of a predetermined length color processed to color A;
hair group 2 consists of hair strands approximately two-thirds the predetermined length of the hair group 1 color processed to color B;
the transitory colored hair formed by combining the hair group 1, which is colored A, and the hair group 2, which is colored B, to form a combination hair 1+2;
a top one-third segment of the combination hair color processed to color C;
wherein a top segment of the combination hair is adapted to be attached near a user's scalp having hair strands of color C;
a bottom segment of the combination hair composed of terminal ends of the hair strands having color A; and
a middle segment of the combination hair having hair strands having a mixture of the color A and the color B forming the transitory colored hair.

US Pat. No. 10,426,207

CLIP APPARATUSES AND METHODS OF MAKING AND USING THE SAME

1. A system comprising:a clip apparatus comprising:
a bottom plate;
a top plate comprising an aperture;
a bridge between the bottom plate and the top plate holding the bottom plate a distance from the top plate;
a resilient frame disposed within the bottom plate, the top plate and the bridge;
a mounded protrusion extending upwardly from the bottom plate toward the top plate, wherein the mounded protrusion extends through the aperture in the top plate such that a top surface of the mounded protrusion extends above a top surface of the top plate and further wherein the top plate and the aperture within the top plate completely surround the mounded protrusion; and
a clothing article disposed over the protrusion and frictionally held in place over the protrusion, and further wherein the clothing article is pushed through the aperture of the top plate by the mounded protrusion.

US Pat. No. 10,426,206

ARTICLE OF APPAREL UTILIZING ZONED VENTING AND/OR OTHER BODY COOLING FEATURES OR METHODS

NIKE, Inc., Beaverton, O...

1. A method, comprising:wetting a garment for at least an upper torso of a wearer, wherein the garment includes a head or neck opening, a waist opening, and two arm openings, and wherein the garment includes a first portion formed of a non-mesh fabric material having an air permeability of less than 550 ft3/min per ft2 measured according to ASTM D737-96 and a second portion including a mesh vented zone extending along a center back portion of the garment, wherein the mesh vented zone has an air permeability of at least 550 ft3/min per ft2 measured according to ASTM D737-96 and has an area of at least 20 in2;
at least 20 minutes prior to a start of an event or exercise routine, wherein the event or exercise routine consists of physical activity that causes a wearer's body temperature to increase as a result of the physical activity, donning the wetted garment and wearing it in a wetted condition so as to cool a wearer's body prior to the start; and
participating in the event or exercise routine.

US Pat. No. 10,426,204

VENTILATED GARMENT

1. A ventilated garment configured to be supported on a back of a wearer, the ventilated garment comprising:an inner panel having a top edge margin, an opposite bottom edge margin, and first and second opposite side edge margins, the inner panel being shaped and arranged for extending vertically along the back of the wearer when the ventilated garment is supported on the back of the wearer such that the bottom edge margin is positioned adjacent a base of the back and the top edge margin is positioned adjacent a neck of the wearer;
an outer panel having a top edge margin, an opposite bottom edge margin, and first and second opposite side edge margins, the first and second side edge margins of the outer panel being joined to the first and second side edge margins of the inner panel such that the inner and outer panels define an air flow guide channel therebetween, the bottom edge margins of the inner and outer panels being spaced apart from one another to define an air intake adjacent the base of the back of the wearer in fluid communication with the air flow guide channel and the top edge margins of the inner and outer panels being spaced apart from one another to define an air flow outlet adjacent the neck of the user in fluid communication with the air flow guide channel, the air flow guide channel fluidly connecting the air intake to the air flow outlet; and
a blower received in the air flow guide channel and configured to draw air into the air flow guide channel through the air intake and to blow the air vertically through the air flow guide channel and out the air flow outlet thereby providing convective cooling of at least one of the neck and a head of the wearer;
wherein the bottom edge margin and the top edge margin of the outer panel each have a generally convex shape.

US Pat. No. 10,426,198

ELECTRICAL CONNECTOR FOR AN ELECTRONIC VAPING DEVICE

ALTRIA CLIENT SERVICES LL...

1. An electronic vaping device comprising:a first section having a male connector, the male connector including
at least one flange on an outer surface of the male connector, at least a portion of the flange having a substantially planar first surface,
male anode portion, and
a male cathode portion; and
a second section having a female connector, the female connector configured to engage the male connector to connect the first section to the second section, the female connector defining a circular internal recess and including,
at least one secant flange on a surface of the defined internal recess, the secant flange having a semi-disk shape and including a surface extending across the defined internal recess,
a female anode portion, and
a female cathode portion.

US Pat. No. 10,426,194

FLAVOR INHALER AND INSIDE HOLDING MEMBER

JAPAN TOBACCO INC., Toky...

1. A flavor inhaler comprising:a cylindrical holding member extending from an ignition end to a non-ignition end;
a combustion heat source provided at the ignition end;
a flavor source provided on the non-ignition end side with respect to the combustion heat source;
an inside holding member that is provided into the cylindrical holding member, and retains at least the flavor source; and
an introduction port that introduces air to the flavor source, wherein
the inside holding member has a first side wall having a cylindrical shape to surround at least a part of the flavor source;
the cylindrical holding member has a second side wall having a cylindrical shape to surround the first side wall;
the introduction port is formed on the first side wall;
the second side wall has a through-hole that is fluidly coupled to external air;
the flavor inhaler further comprises a first flow path and a second flow path, the first flow path connecting the through-hole and the introduction port each other and passing between the first side wall and the second side wall, the second flow path connecting the flavor source and a suction port provided at the non-ignition end of the cylindrical holding member to suck flavor generated at the flavor source; and
a flow-path forming member is formed such that a length of a flavor source outer perimeter segment that is a section corresponding an outer perimeter of the flavor source, in the first flow path, is longer than a shortest length connecting the introduction port and a location where the external air from the through-hole flows into the flavor source outer perimeter segment.

US Pat. No. 10,426,178

DECAFFEINATION METHODS AND SYSTEMS

1. A water based method for producing decaffeinated tea leaves comprising:(i) adding water having a temperature of less than 70° C. (degrees Celsius) to tea leaves to form an aqueous tea leaf mixture;
(ii) separating the tea leaves from the aqueous tea leaf mixture to obtain an aqueous extract and extracted tea leaves;
(iii) contacting the aqueous extract of (ii) with an active carbon adsorbent (ACA);
(iv) adsorbing caffeine in the extract reversibly to the ACA to obtain an aqueous decaffeinated tea extract (DTE);
(v) contacting the aqueous DTE of (iv) with the extracted tea leaves of (ii) to form a further aqueous tea leaf mixture, repeating (ii) to (v) until at least 85% of the caffeine is removed from the tea leaves, wherein
(i) to (v) are water-based, and
the repeating of (ii) to (v) causes an increase in concentration, up to the equilibrium concentration, of non-caffeine water soluble tea components in the aqueous DTE, which causes a reduction of the extraction of non-caffeine water soluble tea components from the tea leaf into the aqueous DTE in the repeated steps, and
(vi) drying the further aqueous tea leaf mixture to obtain the decaffeinated tea leaves, wherein the decaffeinated tea leaves retain at least about 50% of the non-caffeine water soluble components of the tea leaves provided in (i).

US Pat. No. 10,426,167

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

1. A synergistic fungicidal mixture comprising at least one fungicidal multi-site inhibitor selected from the group consisting of captan, chlorothalonil, copper bis(3-phenylsalicylate), copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), copper zinc chromate, cupric hydrazinium sulfate, cuprobam, cuprous oxide, folpet, mancozeb, maneb, metiram, propineb, mancopper and oxine-copper and a fungicidally effective amount of a compound of Formula I:

US Pat. No. 10,426,166

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

6. A synergistic fungicidal composition comprising an agriculturally acceptable adjuvant or carrier and a fungicidally effective amount of the synergistic fungicidal mixture of claim 1.

US Pat. No. 10,426,165

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

15. A synergistic fungicidal composition comprising an agriculturally acceptable adjuvant or carrier and a fungicidally effective amount of the synergistic fungicidal mixture of claim 1.

US Pat. No. 10,426,155

SMALL CHEWING MAMMAL DETERRENT APPARATUS AND METHOD

17. A method is provided for deterring small chewing mammals, comprising:providing an array of green light emitting diodes (LEDs), a power supply, and control circuitry including temperature sensor circuitry and timing circuitry;
distributing the array of green light emitting diodes (LEDs) in an environment having equipment at risk of chewing damage from small chewing mammals;
enabling with the temperature sensor circuitry the operation of the timing circuitry when the ambient temperature is below a threshold temperature determined based on the small chewing mammals; and
enabling with the timing circuitry the operation of the array of green light diodes to illuminate at short intervals with a pulse duration of 10 to 50 milliseconds and a pulse frequency of 0.2 to 5 Hertz to provide a constant photoreceptor effect from 0.00173 to 0.0518 seconds and generate a response in the ocular rod cells of small chewing mammals that annoys small chewing mammals.

US Pat. No. 10,426,153

ROD HOLDER ASSEMBLY

1. A rod holder assembly comprising:a receiving member comprising a cylindrically shaped rod receiver for supporting a fishing rod; a gear assembly engaged to the rod receiver and governing rotational movement of the rod receiver about a horizontal axis comprising a first housing element and a second housing element, wherein the first housing element comprises a first protrusion array affixed to a lateral face of the first housing element and wherein the second housing element comprises a first depression array affixed to a lateral face of the second housing element; and a base assembly governing rotational movement of the rod receiver about a vertical axis comprising a platform engaged to and supporting at least one of said housing elements of the gear assembly; and
a mounting mechanism comprising a cylindrically shaped main housing for supporting and substantially concealing the receiving member, wherein said main housing comprises an open upper end a lower end, and a tubular shaped inner surface for guiding the receiving member's travel through main housing between an exposed position wherein the cylindrically shaped rod receiver is adjustable about the horizontal axis to a substantially concealed position wherein cylindrically shaped rod receiver is not adjustable about the horizontal axis; and
wherein the rod receiver is locked into the substantially concealed position by a retention element.

US Pat. No. 10,426,151

DRAG ADJUSTMENT ASSEMBLY FOR A STAR DRAG REEL

Pure Fishing, Inc., Spir...

1. A drag adjustment assembly comprising:a lever arm unit forming a housing and comprising at least one keyway;
a nut having a threaded inner surface positioned partially in the housing;
a first keyed structure positioned in the housing, wherein the first keyed structure comprises at least one key engaging the at least one keyway and a threaded surface engaging the threaded inner surface of the nut;
a second keyed structure positioned in the housing, wherein the second keyed structure comprises at least one key engaging the at least one keyway; and
a spring secured between the first and second keyed structures.

US Pat. No. 10,426,148

CRAB POT

1. A crab pot, comprising:a top, a bottom, and at least one side wall disposed between the top and the bottom, the top, bottom, and the at least one side wall being supported by a frame and enclosing an interior space;
at least one entrance tunnel in the at least one side wall to permit entry of an animal into the interior space, the at least one entrance tunnel being made of injection molded plastic and including a first end adjacent the at least one side wall, a second end opposite the first end, and a trigger mount monolithically formed in a flat section of the at least one entrance tunnel, where the second end is disposed within the interior space and the trigger mount defines a depression in the flat section of the at least one entrance tunnel;
a trigger comprising at least one rod attached to a pivotable portion, the trigger pivotably mounted via the pivotable portion recessed in the depression in the flat section and on an upper portion of the at least one entrance tunnel at the second end of the at least one entrance tunnel, wherein the trigger pivots away from the first end of the at least one entrance tunnel into the interior space and wherein the depression receives the pivotable portion of the trigger such that the pivotable portion is recessed within the flat section of the at least one entrance tunnel; and
a trigger cover detachably attached to the at least one entrance tunnel to cover the depression such that the pivotable portion of the trigger is covered.

US Pat. No. 10,426,145

WAVE-MAKING PUMP WITH NOVEL DIRECTIONAL STRUCTURE

1. A wave-making pump, comprising a casing, a motor, an impeller that produces a wave, and a fixing device, wherein the motor is fixed in the casing; the impeller is arranged at an output end of the motor; the fixing device is used for fixing the casing; the wave-making pump is characterized in that the casing comprises a rear casing and a diversion protective cover arranged on a front side of the rear casing; openings are formed at two ends of the diversion protective cover; a hollow groove helically extending is formed in peripheral surface of the diversion protective cover; a diversion bar forming an 8 shape along an axis of the diversion protective cover is arranged at one of the openings far from the motor, of the diversion protective cover; the fixing device comprises an outer magnetic sucker, an inner magnetic sucker and a ferromagnetic body arranged in the rear casino, wherein both the outer magnetic sucker and the inner magnetic sucker are provided with a magnet; the outer magnetic sucker and the inner magnetic sucker attract each other to clamp a wall of an aquarium; the ferromagnetic body and the inner magnetic sucker attract each other, so as to ensure that the rear casing is connected with the wall of the aquarium.

US Pat. No. 10,426,144

TERRARIUM AND RELATED METHOD OF USE

1. A terrarium comprising:a base including a first base channel and a second base channel;
a support column including an upper end and a lower end, the column extending upwardly from the base, the lower end secured to the base;
a top including a first top channel and a second top channel, the top being supported entirely by the support column at a first preselected distance from the base;
a first arcuate panel extending between the top and the base, the first arcuate panel being disposed in the first top channel and the first base channel, the first arcuate panel forming an opening between the top and the base;
a second arcuate panel extending between the top and the base, the second arcuate panel being disposed in the second top channel and the second base channel, the second arcuate panel forming a closure of the opening,
wherein at least one of the first and second arcuate panels is a transparent panel,
wherein the first and second arcuate panels cooperate with the top and the base to define an internal compartment,
wherein the support column extends within the internal compartment,
wherein the closure is selectively slidable within the second top channel and the second base channel to provide access to the internal compartment between the top and the base.

US Pat. No. 10,426,143

SYSTEMS AND METHODS FOR LARVAL FISH ENUMERATION AND GROWTH MONITORING

FLORIDA ATLANTIC UNIVERSI...

1. A method for object enumeration in a culture tank, comprising:obtaining an array of two dimensional images of an illuminated scene in the culture tank;
correcting non-uniform background illumination in the two dimensional images;
improving a color contrast between a background and object edges shown in the two dimensional images;
performing a defocus analysis using the two dimensional images to generate a focus map image;
generating a modified focus map image by eliminating isolated spots shown in the focus map image and merging small spots with adjacent large objects in the focus map image;
classifying each object shown in the modified focus map image as an object of interest or an object of no interest, wherein the object of interest comprises larvae and the object of no interest comprises bubbles and feed; and
counting a number of objects classified as objects of interest.

US Pat. No. 10,426,139

PET GROOMING ENCLOSURE

1. An accessory for grooming an animal comprising:an enclosure that is adapted to receive an animal;
wherein said enclosure includes a plurality of suction nozzles that are adapted to collect water and debris from said animal;
wherein the enclosure is further defined with a top portion and a bottom portion;
wherein the top portion is affixed to and is seated onto the bottom portion along a perimeter edge;
wherein the enclosure includes a first opening and a second opening;
wherein the first opening includes a door that is attached to both the top portion and the bottom portion;
wherein the door pivots with respect to the enclosure via a top hinge and a bottom hinge;
wherein the top hinge connects to both the door and the top portion;
wherein the bottom hinge connects to both the door and the bottom portion;
wherein the first opening is provided on a front surface of the enclosure;
wherein the door provides access to an interior of the enclosure;
wherein the second opening is provided on a rear surface of the enclosure;
wherein the rear surface is distal of the front surface;
wherein the rear surface and the front surface are separated from one another via an enclosure length;
wherein the enclosure is adapted to receive said animal within the interior;
wherein the enclosure includes the plurality of vacuum nozzles within the interior of the enclosure;
wherein the plurality of vacuum nozzles are strategically located throughout the interior of the enclosure in order to adaptively remove water and debris from said animal.

US Pat. No. 10,426,137

ANIMAL TROUGH

1. An animal trough comprising:an inner wall with an inner surface and an elliptic, arcuate outer surface;
an outer wall with an inner surface and outer surface;
a compartment configured to removably receive a first fluid and formed between the inner surface of the inner wall and the inner surface of the outer wall;
a receptacle with an inverted, elliptic dome-shape that is configured to receive a second fluid and that is defined by the elliptic, arcuate outer surface of the inner wall, such that the receptacle is smooth and the inner wall separates the compartment from the receptacle such that the first fluid is separated from the second fluid; and
an insert including an insert outer surface shaped to substantially conform to the elliptic, arcuate outer surface of the inner wall when the insert is removably nested within the receptacle, the insert being configured to remove debris from the receptacle when removed from the receptacle.

US Pat. No. 10,426,130

COLLAPSIBLE PET CARRIER

1. A collapsible pet carrier comprising:an interior space defined between opposing side walls, opposing end walls, and a bottom wall;
one or more straps attached to one of the opposing side walls and opposing end walls;
a cover movably attached over a top opening of the collapsible carrier;
a pair of opposing pockets located on an exterior portion of the bottom wall, the pair of opposing pockets separated by a slit;
a board shaped to fit at least partially within the pair of opposing pockets and across the slit;
a closure mechanism formed along an edge of the exterior portion of the bottom wall;
wherein in an expanded configuration the board is located at least partially within both of the pair of opposing pockets of the bottom wall; and
wherein in a collapsed configuration the board does not extend across the slit such that opposing side walls, opposing end walls, straps, and cover are folded towards the bottom wall and the bottom wall is folded along a center of the bottom wall and secured closed with the closure mechanism.

US Pat. No. 10,426,117

LETTUCE VARIETY 79-135 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A seed of lettuce variety 79-135 RZ, a sample of seed of said variety having been deposited under NCIMB Accession No. 42678.

US Pat. No. 10,426,108

ASSEMBLY WELL IRRIGATION SYSTEM FOR ENVIRONMENTALLY FRIENDLY WATER CONSERVATION

1. An assembly well irrigation system for environmentally friendly water conservation, comprising:at least one well, having a ventilation tube inserted into the top of the well, an absorbent element covered onto the bottom and outer wall of the ventilation tube and filled up in an opening formed between the top of the well and the ventilation tube, and a float contained in the ventilation tube; and
at least one water supply bottle, having a cover installed to the opening of the water supply bottle, and the cover having a fixed tube passing through the cover and a penetrating hole formed on the cover, and the penetrating hole having a movable tube capable of moving up and down for an adjustment, and the water supply bottle being inverted, such that the cover is installed to the well, and the fixed tube, the movable tube and the ventilation tube are situated in the well.

US Pat. No. 10,426,104

PRESSURE COMPENSATING EMITTER HAVING VERY LOW ACTIVATION PRESSURE AND LARGE OPERATING RANGE

Massachusetts Institute o...

1. Pressure-compensating emitter comprising:an inlet connected to a source of pressurized water;
an orifice in fluid communication with the inlet and extending into a channel including a raised land surrounding an outlet; and
a compliant membrane positioned above the land in the chamber wherein the pressurized water will cause the membrane to deform into contact with the land to alter flow through the outlet;
wherein dimensions of the orifice, land diameter, channel dimensions, outlet diameter and membrane characteristics are selected to provide substantially constant flow for varying water pressure with an activation pressure of 0.15 bar or below wherein the compliant membrane sits above the raised land by approximately 0.7 mm.

US Pat. No. 10,426,101

PLANT POT WITH IRREGULAR BOTTOM EDGE

1. An expandable planter pot for insertion into the ground, the pot comprising:a plurality of adjacent arcuate sections forming the expandable planter pot, a size of the expandable planter pot increasing or decreasing based on a number of adjacent arcuate sections included in the plurality of adjacent arcuate sections forming the expandable planter pot;
wherein each of the plurality of adjacent arcuate sections has a pair of upper connection tabs and a pair of lower connection tabs;
wherein each of the plurality of adjacent arcuate sections is joined to another adjacent arcuate section by aligning openings of the pair of upper connection tabs and openings of the pair of lower connection tabs of each arcuate section, using zip tie closures through the respective openings, thereby forming a continuous, unbroken sidewall of said planter pot, said sidewall comprising an upper rim and a lower peripheral edge that defines an open bottom, said lower peripheral edge comprising a formation of serrated teeth suitable for gouging the ground, wherein the pot is rigid for inserting into the ground by rotating the pot to gouge the ground;
wherein each of the pair of upper connection tabs:
is defined by the upper rim of each of the plurality of adjacent arcuate sections,
is integrated with the upper rim, and
forms a wall at both ends of the upper rim;
wherein each of the pair of upper connection tabs extends horizontally outward from an interior of the pot;
wherein each of the pair of lower connection tabs extends horizontally inward along a vertical cross-section of each of the plurality of adjacent arcuate sections; and
wherein said lower peripheral edge defines the open bottom so that the expandable planter pot is bottomless.

US Pat. No. 10,426,095

AGRICULTURAL BALER WITH PLUNGER REPOSITION DURING STARTUP MODE

1. An agricultural harvesting machine for crop material comprising:a crank arm connected to a rotational power source;
a plunger having an extended position which is located further rearward in a compression chamber than a retracted position; and
a connecting link connected between the plunger and the crank arm, one of the connecting link and the crank arm having a variable length;
a startup mode in which the rotational power source accelerates up to an operational speed, the movement of the plunger being decoupled from the movement of the crank arm at the beginning of the startup mode, the plunger moving to a retracted position after the rotational power source has attained an intermediate speed which is less than the operational speed, and the plunger remains in the retracted position until the rotational power source has attained the operational speed; and
a run mode in which the rotational power source has attained the operational speed, and the movement of the plunger being coupled to the movement of the crank arm during the run mode.

US Pat. No. 10,426,093

CONICAL ROTOR DISCHARGE HOUSING WITH ADJUSTABLE VANES

CNH Industrial America LL...

1. A threshing system for an agricultural harvester, the threshing system comprising:a rotor comprising an elongated body having a longitudinal axis, the elongated body having a proximal end adapted to receive material from a feeding mechanism and a distal end opposite the proximal end;
a cage that surrounds at least a portion of the proximal end of the rotor, the cage comprising an inner surface spaced radially apart from the rotor to define a threshing space between the rotor and the cage;
a discharge housing that surrounds at least a portion of the distal end of the rotor, the discharge housing comprising a side wall spaced radially apart from the rotor to define a discharge passage between the rotor and the discharge housing; and
a plurality of adjustable vanes mounted to the side wall of the discharge housing at a downswept side of the rotor, each adjustable vane extending radially from the inner surface of the discharge housing and into the discharge passage, each vane being movable relative to an adjacent portion of the discharge housing between a first position in which the vane is at a first helical angle relative to the longitudinal axis and a second position in which the vane is at a second helical angle relative to the longitudinal axis to thereby change a trajectory of the material expelled from the discharge passage and out of the threshing system,
wherein the vanes are axially spaced apart from each other such that a space is formed between the vanes along which material can pass.

US Pat. No. 10,426,088

CENTER FEED ASSEMBLY FOR A DRAPER

1. A draper head for a combine, the draper header comprising:a center section adapted for attachment to the combine and provided with a center feed assembly, the center feed assembly including first and second belt frames each supporting a drive roller, an idler roller, and a belt extending between the drive roller and the idler roller; and
first and second wings extending in opposite lateral directions from the center section, each of the first and second wings including a draper belt operable to feed crop material toward the center section,
wherein the second belt frame is movable relative to the first belt frame.

US Pat. No. 10,426,087

USER INTERFACE PERFORMANCE GRAPH FOR OPERATION OF A MOBILE MACHINE

1. A computer-implemented method, comprising:detecting a first set of sensor signals output by at least one of a grain loss sensor and a yield sensor implemented with an agricultural machine;
generating productivity performance metric values, based on the first set of sensor signals;
detecting a second set of sensor signals output by an image processing system implemented with the agricultural machine;
generating quality performance metric values, based on the second set of sensor signals;
displaying, on a user interface display, a time continuous display including:
a productivity strip chart that visually identifies the productivity performance metric values along a timeline of operation of the agricultural machine, and
a set of quality strip charts, each quality strip chart visually identifying one of the quality performance metric values along the timeline of operation;
defining a productivity performance window including a range of productivity threshold values, based on the productivity performance metric values;
defining a quality performance window including a range of quality threshold values, based on the quality performance metric values;
displaying, on the user interface display, the productivity performance window along the productivity strip chart and the quality performance window along the set of quality strip charts of the time continuous display;
automatically generating a control signal that controls operation of the agricultural machine, with a corresponding adjustment that is automatically applied to one or more settings of a controlled system to maintain a desired level of operating performance, based on a determination that at least one of the productivity performance metric values deviates outside of the range of productivity threshold values or a determination that at least one of the quality performance metric values deviates outside of the range of quality threshold values;
displaying, on the user interface display, an indication of where, along the time continuous display, the control signal is automatically generated along the timeline of operation of the agricultural machine;
based on receiving a drill input, selecting one of the quality performance metric values and displaying a more detailed display indicative of more detailed information corresponding to the selected quality performance metric value derived from the second set of sensor signals, and wherein displaying a more detailed display comprises:
displaying, along the timeline and with one or more of the quality strip charts, a time continuous display for each of a plurality of additional metric values derived from the second set of sensor signals and associated with the selected quality performance metric value.

US Pat. No. 10,426,084

MOWER CAPABLE OF EFFECTIVELY COOLING A MOTOR

KUBOTA CORPORATION, Osak...

1. A mower comprising:at least one rotationally driven grass cutting blade;
at least one motor having a motor housing and being configured to cause rotation of the grass cutting blade;
a mower deck having an upper surface and an outer wall that extends down from the upper surface, said outer wall and said upper surface defining an interior that houses the grass cutting blade;
at least a part of the motor extending into the interior of the mower deck;
at least another part of the motor extending above the upper surface of the mower deck;
at least one guide member surrounding and being spaced apart from a portion of the motor housing of said motor; and
said at least one guide member being located entirely in the interior of the mower deck and below the upper surface of the mower deck,
wherein an air flow from outside the mower deck moves radially inwards inside the interior of the mower deck towards a motor shaft and is guided by the at least one guide member,
wherein the outer wall of the mower deck surrounds the grass cutting blade and the at least one guide member, and
wherein the at least one guide member defines an annular air flow passage along an outside of the motor, said air flow passage connecting the interior and an exterior of the mower deck.

US Pat. No. 10,426,083

BLADE ASSEMBLY FOR A GRASS CUTTING MOBILE ROBOT

iRobot Corporation, Bedf...

1. A grass cutting mobile robot comprising:a drive system operable to navigate the robot about a mowable area; and
a blade assembly comprising a housing and a blade to cut vegetation on the mowable area, the blade comprising:
a first portion extending outwardly from the housing and defining a longitudinal axis, a proximal end of the first portion mounting the blade to the housing on a mounting axis at a non-parallel angle to a vertical axis;
a second portion extending from a distal end of the first portion at an angle to the longitudinal axis; and
a third portion extending from a distal end of the second portion in a direction parallel to the longitudinal axis, the third portion being offset by a distance from the first portion, and a distal end of the third portion being angled in a first direction with respect to the longitudinal axis and tapered in a second direction with respect to the longitudinal axis to form a blade cutting tip, the third portion of the blade comprising a cutting portion configured to cut the vegetation on the mowable area, the cutting portion of the blade being coincident with a radial axis of the blade assembly.

US Pat. No. 10,426,081

ATTACHABLE STORAGE DEVICE FOR A LANDSCAPE MACHINE

1. A landscaping machine comprising:a protective rollover bar having a left bar portion extending from a left side of an operator seat, a top bar portion extending from the left bar portion above the operator seat, and a right bar portion extending from the top bar portion to a right side of the operator seat;
a storage device attached to the protective rollover bar, wherein the storage device comprises a support bar extending between and attached to the left bar portion and the right bar portion; and
wherein the storage device includes a receptacle that is configured to hold loose objects during operation of the landscaping machine, wherein the receptacle comprises an inner storage cavity, and wherein the support bar is configured to rotate about at least one of the left bar portion and the right bar portion while remaining attached to the protective rollover bar such that an axis of rotation of the storage device is at least substantially parallel to at least one of the left bar portion and the right bar portion.
US Pat. No. 10,429,385

TREATING CONDITIONS ASSOCIATED WITH SEPSIS

TLA TARGETED IMMUNOTHERAP...

1. A method for treating sepsis in a subject in need thereof, which comprises applying peripheral blood from the subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine CXCR1 receptor immobilized directly or indirectly on the support, whereby one or more cells expressing chemokine receptor CXCR1 are removed from the peripheral blood of the subject, wherein the applied blood is recirculated back into the systemic circulation of the subject, and whereby the sepsis is treated.
US Pat. No. 10,426,823

METHODS FOR CONSTRUCTING ANTIBIOTIC RESISTANCE FREE VACCINES

THE TRUSTEES OF THE UNIVE...

1. A composition comprising an antibiotic resistance gene-free plasmid, said plasmid comprising: i) a first nucleic acid sequence encoding a polypeptide, wherein said polypeptide is a fusion protein comprising a heterologous antigen and a non-hemolytic Listeriolysin (LLO) protein or N-terminal fragment thereof, and ii) a second nucleic acid sequence encoding a metabolic enzyme.
US Pat. No. 10,428,359

METHOD FOR PRODUCING L-AMINO ACID

AJINOMOTO CO, INC., Toky...

1. A method for producing an L-amino acid, the method comprising the steps of:A) culturing a bacterium having an L-amino acid-producing ability in a medium resulting in accumulation of an L-amino acid in the medium; and
B) collecting the L-amino acid from the medium;
wherein the bacterium has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier is increased as compared with a non-modified bacterium,
wherein the C4-dicarboxylic acid-uptake carrier is a protein encoded by a gene selected from the group consisting of a dctA gene, a dcuA gene, a dcuB gene, and combinations thereof, and
wherein the L-amino acid is an L-amino acid other than L-aspartic acid,
provided that the L-amino acid is L-glutamic acid when the C4-dicarboxylic acid-uptake carrier is a protein encoded by a dctA gene, and
provided that the bacterium has further been modified so as to harbor a mutant yggB gene when the bacterium is a coryneform bacterium and the C4-dicarboxylic acid-uptake carrier is a protein encoded by a dctA gene.
US Pat. No. 10,429,129

METHOD OF MICROWAVE VACUUM DRYING SPHERICAL-SHAPED PELLETS OF BIOLOGICAL MATERIALS

1. A method of preparing a dried pellet of an enveloped live virus, comprising:a) dispensing an aliquot of a liquid composition comprising the enveloped live virus as a single droplet onto a solid surface, wherein the temperature of the solid surface is at ?90° C. or below, in a manner that maintains the droplet as a single droplet as it contacts and freezes on the surface as a frozen pellet;
b) applying microwave radiation in a traveling wave format at a power in a range of between 0.5 and 8 KW/hr/Kg to the frozen pellet under a pressure below atmospheric pressure to produce a dried pellet;wherein the drying yield, as obtained by a plaque assay, is greater than or equal to 50%.
US Pat. No. 10,429,386

ANTIBODIES TO THE SURFACE OF TOXOPLASMA GONDII OOCYSTS AND METHODS OF USE THEREOF

The Regents of the Univer...

1. A method of specifically detecting an intact Toxoplasma gondii oocyst in a sample, the method comprising:a) contacting a sample suspected of containing a T. gondii oocyst with an IgG monoclonal antibody that specifically binds a protein on the outer wall of an intact T. gondii oocyst under conditions sufficient to form an immunocomplex of the antibody with the intact T. gondii oocyst; and
b) specifically detecting the presence or absence of the immunocomplex comprising the antibody.
US Pat. No. 10,426,824

COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS

The General Hospital Corp...

1. A method of treating cancer in a single subject in need thereof comprising:(a) comparing:
(i) nucleic acid sequences obtained by whole genome sequencing or whole exome sequencing of cancer cells from the single subject to,
(ii) nucleic acid sequences obtained by whole genome sequencing or whole exome sequencing of non-cancer cells from the single subject;
(b) identifying a plurality of cancer specific nucleic acid sequences that are specific to the cancer cells of the single subject based on (a),
wherein the identified plurality of cancer specific nucleic acid sequences encodes two or more different peptide sequences of two or more different proteins that are expressed by the cancer cells, and
wherein each of the two or more different peptide sequences of the two or more different proteins comprise a cancer specific amino acid mutation that is not present in the non-cancer cells from the single subject;
(c) calculating binding affinities of the two or more different peptide sequences encoded by the plurality of cancer specific nucleic acid sequences identified in (b) to a protein encoded by an HLA allele of the single subject by an HLA peptide binding analysis using a program implemented on a computer system;
(d) selecting at least two peptide sequences calculated in (c) to have a binding affinity to a protein encoded by an HLA allele of the single subject with an IC50 of less than 500 nM;
(e) administering a pharmaceutical composition to the single subject, wherein the pharmaceutical composition comprises one or more polypeptides comprising the at least two peptide sequences selected in (d) or one or more polynucleotides encoding the at least two peptide sequences selected in (d).
US Pat. No. 10,428,104

SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS

Pfizer Inc., New York, N...

1. A compound selected from:(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methylphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-chloro-4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methoxyphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
5-((R)-((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)(hydroxy)methyl)-2-fluorobenzonitrile,
(2R,3S,4R,5R)-2-((R)-(2-(dimethylamino)pyridin-4-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indazol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(3-(trifluoromethyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(3S,4R,5R)-2-((3-fluoro-5-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(3-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(4-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-(difluoromethyl)benzofuran-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-6-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-1-hydroxy-2-(phenylsulfonyl)ethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2((S)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((1H-pyrazol-1-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(3S,4R,5R)-2-(difluoro(4-fluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxypropyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxybutyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(oxazol-5-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(hydroxymethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(1H-pyrazol-5-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(1-methyl-1H-pyrazol-3-yl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(3-(ethoxymethyl)-1H-pyrazol-5-yl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(1,2-dihydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
((3aS,4S,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxo1-4-yl)(2-(methylsulfonyl)phenyl)methanone,
(2R,3S,4R,5R)-2-((R)-hydroxy(1H-indol-7-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(5-fluoropyridin-2-yl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chlorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(S)-1-((3aR,4S,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethan-1-ol,
2-((3aR,4R,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propan-2-ol,
(3,4-difluorophenyl)((2S,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)methanone,
(2S,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)fluoromethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-(3,4-difluorophenyl)fluoromethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(3,4-difluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-amino(3,4-difluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-(difluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-(difluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(5-fluoro-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2,4-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-(4-fluorobenzyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(4-fluorobenzyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-(3,4-difluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-1-(3,4-difluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-(4-chloro-3-fluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-1-(4-chloro-3-fluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-(fluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(methylamino)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(6-methylpyridin-3-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(2-methylpyridin-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
6-((R)-((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)(hydroxy)methyl)pyridin-2(1H)-one,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-(hydroxymethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(4-chloro-3-fluorophenyl)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(3,4-difluorophenyl)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, and
(2R,3R,4S,5R)-2-(2-amino-5-fluoro-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol acetate,
or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,428,361

BIOCATALYTIC PRODUCTION OF L-FUCOSE

BASF SE, Ludwigshafen am...

1. A method for producing L-fucose, comprising the following steps:(a) providing L-fucitol, a galactose oxidase of the enzyme class EC 1.1.3.9, a peroxidase and a catalase,
(b) combining L-fucitol, the galactose oxidase, the peroxidase, and the catalase to form a mixture,
(c) incubating the resulting mixture under conditions permitting the biocatalytic oxidation of L-fucitol to L-fucose, and
(d) optionally isolating the synthesized L-fucose.
US Pat. No. 10,429,388

METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING ROUNDWORM, WHIPWORM AND HOOKWORM

Idexx Laboratories, Inc.,...

1. An immunocomplex comprising a first antibody specifically bound to a polypeptide, wherein the first antibody is capable of specifically binding to an amino acid sequence of SEQ ID NO:19-23, 38, or Copro6728.
US Pat. No. 10,426,827

DENGUE HEMORRHAGIC FEVER VIRUS VACCINE

MicroVAX, LLC, Warrenton...

1. A composition for generating a humoral and cellular immune response in an individual against four strains of the Dengue Hemorrhagic Fever Virus (DHFV) with the E antigenic protein of the DHFV, in the form of a multi expression vector mixture comprising twelve expression vectors each of which comprises an effective amount of a nucleic acid encoding a secretable fusion protein comprising one of twelve distinct epitopes SEQ ID NOS. 1-12 from Domain III of the E protein, wherein said twelve distinct epitopes comprise three separate fragments from each of said four strains, each of said twelve epitopes recognized and bound by Class I and Class II MHC capable to generate both neutralizing antibodies and CD8 effector T cells, and wherein each of said twelve epitopes is separately linked to the N-terminal end of the extracellular domain of a CD40 ligand to define one of twelve distinct sub-compositions, and to collectively define said multi-expression vector mixture composition that is potent to anticipate immunological escape to heterologous strains of the DHFV thereby providing protection against related but not identical DHFV viruses.
US Pat. No. 10,429,391

BIOMARKERS FOR CHOLANGIOCELLULAR CARCINOMA (CCC)

1. A method for identifying biomarkers for cholangiocellular carcinoma (CCC), comprising:a) collecting tumorous tissue samples and non-tumorous tissue samples from at least 5 patients with CCC;
b) comparing the tumorous tissue samples with the non-tumorous tissue samples by two-dimensional differential in-gel electrophoresis (2D-DIGE) and thereby identifying a first set of biomarker candidates for CCC showing different expression in tumorous tissue and non-tumorous tissue determined by statistical analysis;
c) comparing the tumorous tissue samples with the non-tumorous tissue samples by label-free liquid chromatography-mass spectrometry (LC-MS) and thereby identifying a second set of biomarker candidates for CCC showing different expression in tumorous tissue and non-tumorous tissue determined by statistical analysis;
d) comparing the first set of biomarker candidates obtained by 2D-DIGE according to step b) with the second set of biomarker candidates obtained by label-free LC-MS according to step c) and thereby identifying a third set of biomarker candidates for CCC showing different expression with both 2D-DIGE and label-free LC MS; and
e) performing an immunohistochemical analysis of the third set of biomarker candidates for CCC identified from step d) by comparing the expression of a respective biomarker candidate in the tumorous tissue of a subject with the expression of said respective biomarker candidate in non-tumorous tissue of the same subject and selecting one or more biomarkers for CCC that display a sensitivity of 40% or more.
US Pat. No. 10,426,829

VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY

Novavax, Inc., Gaithersb...

1. A vaccine composition comprising:(i) a nanoparticle comprising a non-ionic detergent core and a viral glycoprotein,
wherein the viral glycoprotein is associated with the core; wherein the non-ionic detergent is PS80 wherein the viral glycoprotein is an RSV F glycoprotein and the molar ratio of PS80 to viral glycoprotein is about 30:1 to about 60:1; and
(ii) a pharmaceutically acceptable buffer.
US Pat. No. 10,429,648

AUGMENTED REALITY HEAD WORN DEVICE

1. An augmented reality head worn device comprising;a. a curved transparent mirror,
b. a scanning light source defining a field of view,
c. a holographic optical element (HOE) adapted to provide exit pupil expansion to create an enlarged eye-box, and
d. at least one projection system for providing pixels optically mapped to a pixel density;
wherein modulated red, green and blue lasers and a MEMS mirror micro-scanner are utilized to encode a display video illumination through conditioning and focusing optics onto the HOE and the HOE corrects for optical aberrations, replicates an image signal to create hexagonally packed exit pupil eye-box spots which are then redirected toward the curved transparent mirror which in turn directs the hexagonally packed exit pupil eye-box spots into the enlarged eye-box wherein the hexagonally packed exit pupil spots create the enlarged eye-box.
US Pat. No. 10,428,366

COLLAGENASE ASSAY

University of South Flori...

1. A method of measuring bacterial collagenase activity in a sample, comprising:staining native collagen fibrils with a dye at saturation level, said collagen fibrils being dry or lyophilized, said dye being capable of stably staining said collagen fibrils;
suspending said dyed collagen fibrils in a collagenase substrate buffer;
incubating said dyed collagen fibril suspension at about 37° C., wherein bacterial collagenase activity results in digestion of said dyed collagen fibrils into smaller, dyed collagen particulates that can be readily observed in a resulting mixture;
filtering said mixture to retain said dyed collagen particulates, wherein said dyed collagen particulates are digested and collected in a resulting filtrate;
extracting said dye from said filtrate to determine an amount of said digested dyed collagen particulates;
measuring absorbance of said extracted dye to determine an amount of said digested collagen particulates;
wherein said native fibrils are not solubilized by acid or gelled by heat, and
wherein said native fibrils are Type I collagen found in an animal body.
US Pat. No. 10,428,111

CANCER TARGETING BY ANTI-EGFR PEPTIDES AND APPLICATIONS THEREOF

1. A liposomal composition, comprising:a molecule; and
a lipid phase comprising a phospholipid, a PEGylated phospholipid, and cholesterol with molar ratio of between 50:30:5 and 60:40:5,
wherein the molecule consists of a lipid conjugated to a peptide through at least one linker with a molar ratio of the peptide to the lipid of 1.2:1,
wherein the peptide includes an amino acid sequence selected from the group consisting of LTVSPWY (SEQ ID NO: 1), MYWGDSHWLQYWYE (SEQ ID NO: 2), FCDGFYACYADV (SEQ ID NO: 3), IHNRYNRFFYWY (SEQ ID NO: 4), PRWGDSHWLQYWYE (SEQ ID NO: 5), LMWGGSHWLEYWYE (SEQ ID NO: 6), GHWGDQHWLQYWYE (SEQ ID NO: 7), GWWGDSHWLQYWYE (SEQ ID NO: 8), LTVEPWL (SEQ ID NO: 9), LTVSPLWD (SEQ ID NO: 11), LTVTPWL (SEQ ID NO: 12), LTVQPWP (SEQ ID NO: 13), LTVSPWT (SEQ ID NO: 14), VLTVQPW (SEQ ID NO: 15), LTVSLWT (SEQ ID NO: 16), PGVIPWN (SEQ ID NO: 17), LTYQTWP (SEQ ID NO: 18), and ELYVSRL (SEQ ID NO: 19), and
wherein the molecule comprises a spacer at N-terminal or C-terminal of the peptide, said spacer is the amino acid sequence CGGG as set forth in SEQ ID NO: 10,
wherein the liposomal composition comprises a plurality of liposomes, the plurality of liposomes comprising the molecule with a density between 25 and 200 molecules per liposome.
US Pat. No. 10,429,394

MONOCLONAL ANTIBODIES AGAINST KIR2DS1

National University Corpo...

7. A monoclonal antibody to KIR2DS1 that is produced by at least one hybridoma selected from the group consisting of a hybridoma with Accession No. NITE BP-01853, a hybridoma with Accession No. NITE BP-01855, and a hybridoma with Accession No. NITE BP-01854 or a fragment comprising an antigen-binding region thereof.
US Pat. No. 10,428,113

COMPOSITIONS FOR EXPANDING REGULATORY T CELLS (TREG), AND TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND CONDITIONS

THE REGENTS OF THE UNIVER...


US Pat. No. 10,427,090

CONTROL OF SWING ADSORPTION PROCESS CYCLE TIME WITH AMBIENT CO2 MONITORING

PRAXAIR TECHNOLOGY, INC.,...

1. A method for maximizing the time an adsorbent bed can remain online in feed mode in a swing adsorption process without experiencing breakthrough of adsorbate, wherein said swing adsorption process comprises at least two adsorbent beds each having a predetermined design bed capacity, wherein one adsorber bed is online in feed mode during which adsorbate is adsorbed from a feed gas mixture passing through the bed, while another adsorbent bed is in regeneration mode, during which the adsorbed component is desorbed from the bed, wherein the beds alternate between said modes, said method comprising:a) Repeatedly measuring the feed gas flow rate, feed gas temperature, feed gas pressure and the concentration levels of adsorbate in said feed gas during the on-stream mode;
b) Calculating the perturbation front velocity of the adsorbate through the adsorbent bed when there is a an instantaneous variation of ambient levels of said adsorbate in the feed gas;
c) Calculating the breakthrough time of said adsorbate based on the perturbation front velocity of said adsorbate through the adsorbent bed, and
d) Updating the bed capacity and the online cycle time to maximize the time that the adsorbent bed can remain online in feed mode without experiencing breakthrough of said adsorbate.
US Pat. No. 10,428,116

RHINOVIRUS C IMMUNOGENIC PEPTIDES

Wisconsin Alumni Research...

1. A composition comprising a peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and a heterologous carrier protein, wherein the peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:1, 3, 6, 8, 11, 13, 15, 17, 19, 21, 23, 25, 27, 30, 33, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 57, 59, 61, 63, 65, 67, 48, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 117, 119, 121, 123, 125, and 127.
US Pat. No. 10,428,373

DUPLICATING DNA WITH CONTIGUITY BARCODES FOR GENOME AND EPIGENOME SEQUENCING

The Regents of the Univer...

1. A method for sequencing a template polynucleotide comprising:(a) contacting the template polynucleotide with a plurality of oligonucleotide pairs, wherein each member of each oligonucleotide pair comprises (i) an adaptor sequence, (ii) a unique barcode sequence that hybridizes to its complement on the other member of the oligonucleotide pair, and wherein one or both of the oligonucleotide pairs comprises (iii) a primer sequence that hybridizes to the template polynucleotide;
(b) contacting the template polynucleotide and plurality of oligonucleotide pairs with a polymerase lacking strand displacement activity and reagents necessary for polymerization, and
(c) allowing extension of a polynucleotide strand from the 3? end of the primer sequence to produce an extended polynucleotide comprising components (i)-(iii) and a sequence complementary to the template polynucleotide;
(d) collecting the extended polynucleotides;
(e) sequencing the extended polynucleotides; and
(f) assembling the sequences of the extended polynucleotides based on the unique barcodes, thereby sequencing the template polynucleotide,
wherein the method does not include fragmenting the template, damaging the polynucleotide or removing epigenetic markers on the template polynucleotide.
US Pat. No. 10,428,118

HUMAN CYTOMEGALOVIRUS COMPRISING EXOGENOUS ANTIGENS

1. A recombinant human cytomegalovirus (HCMV) comprising:(1) a nucleic acid encoding at least one heterologous antigen,
(2) an inactivating mutation in the UL82 gene, and
(3) active US2, US3, US6, US7, UL131A, and UL97 genes;
wherein the recombinant HCMV is a genetically modified TR strain of HCMV; and the recombinant HCMV is Ganciclovir sensitive.
US Pat. No. 10,428,119

PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES

The United States of Amer...

1. A Pseudomonas exotoxin A (PE) comprising the amino acid sequence of Formula I:FCS-R1m—R2p—R3n-PE functional domain III   (Formula I),
wherein:
m, n, and p are, independently, 0 or 1;
FCS comprises a furin cleavage amino acid sequence;
R1 comprises 1 or more continuous amino acid residues of residues 285-293 of SEQ ID NO: 1;
R2 comprises X1VAX2X3X4AAX5LSW (SEQ ID NO: 2), wherein X1, X2, and X4 are independently leucine, alanine, glycine, serine, or glutamine; X3 is tyrosine, alanine, glycine, serine, or glutamine; and X5 is arginine, alanine, glycine, serine, or glutamine; with the proviso that the PE does not comprise LVALYLAARLSW (SEQ ID NO: 3) and that when X5 is alanine, at least one of X1, X2, X3, and X4 is alanine, glycine, serine, or glutamine;
R3 comprises 1 or more continuous amino acid residues of residues 306-394 of SEQ ID NO: 1; and
PE functional domain III comprises residues 395-613 of SEQ ID NO: 1 with a substitution of amino acid residue D463,
optionally with a substitution of one or more amino acid residues within one or more B-cell epitopes of SEQ ID NO: 1; and/or
optionally with a substitution of one or more amino acid residues within one or more T cell epitopes within amino acid residues R421, L422, L423, A425, R427, L429, Y439, H440, F443, L444, A446, A447, I450, amino acid residues at positions 464-519, R551, L552, T554, I555, L556, and W558 of SEQ ID NO: 1.
US Pat. No. 10,427,096

METHOD AND SYSTEM FOR CONTROLLING MERCURY EMISSIONS FROM COAL-FIRED THERMAL PROCESSES

ADA-ES, INC., Highlands ...

1. A method, comprising:providing a mercury-containing gas stream generated from a combustible source having native mercury and native halogens, wherein the mercury-containing gas stream comprises a vapor-phase mercury, a vapor-phase halogen, and first particulates;
introducing, into the mercury-containing gas stream, a reactive surface agent to collect at least most of the halogen and the mercury, wherein the reactive surface agent comprises second particulates, and wherein the second particulates comprise one or more of a clay and a carbon sorbent; and
thereafter removing the first and second particulates from the mercury-containing gas stream to form a treated stream, at least a portion of the vapor-phase mercury being removed from the mercury-containing gas stream with removal of the first and second particulates,
wherein at least one of the following is true:
(i) the mercury-containing gas stream comprises about 3.5 ppmw or less of a vapor-phase iodine;
(ii) in the mercury-containing gas stream, a molar ratio of the vapor-phase iodine to the vapor-phase mercury is no more than about 600;
(iii) at an air preheater outlet, a concentration of the vapor-phase iodine ranges from about 0.1 to about 10 ppmw; and
(iv) a concentration of the iodine is about 30 ppmw or less relative to a weight of a mercury-containing feed material producing the vapor-phase mercury.
US Pat. No. 10,428,376

RNA AMPLIFICATION AND OLIGONUCLEOTIDE LIBRARY PREPARATION

REGENTS OF THE UNIVERSITY...

1. A method of amplifying an RNA template, the method comprising:annealing a primer to the RNA template, the primer comprising:
a region complementary to a portion of the RNA template; and
a digestible oligonucleotide adapter comprising RNA, DNA, an RNA/DNA hybrid, LNA, PNA, an oligonucleotide comprising at least one modified nucleotide, at least a portion of a plasmid, or at least a portion of a virus;
synthesizing an oligonucleotide from the primer, thereby producing a product that comprises a nucleotide strand complementary to the RNA template having the digestible oligonucleotide adapter;
isolating at least a portion of the oligonucleotide; and
subjecting the isolated product to treatment that digests at least a portion of the digestible adapter but does not digest the nucleotide strand complementary to the RNA template.
US Pat. No. 10,431,451

METHODS AND APPARATUSES FOR INCREASING REACTOR PROCESSING BATCH SIZE

LAM RESEARCH CORPORATION,...

1. A method of increasing a reaction chamber batch size, the method comprising:(a) processing a portion of a batch of wafers within the reaction chamber, wherein the processing results in at least some off-target deposition of material on interior surfaces of the reaction chamber;
(b) without cleaning the chamber, conducting a mid-batch reaction chamber processing to stabilize the off-target deposition material accumulated on interior surfaces of the reaction chamber comprising depositing a dielectric film coating that binds to the material on the interior surfaces of the reaction chamber; and
(c) processing another portion of the batch of wafers within the reaction chamber.
US Pat. No. 10,428,121

NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B

Novartis AG, Basel (CH) ...

1. A fusion polypeptide consisting of (i) a polypeptide which has at least 95% sequence identity to SEQ ID NO: 4212 and (ii) a heterologous sequence.
US Pat. No. 10,428,123

CONSTITIUTIVE PROMOTER

Lonza Ltd, Visp (CH)

1. An expression construct comprising a pCS1 promoter which is any of:i) a promoter comprising the nucleic acid sequence identified as SEQ ID NO: 1, or
ii) a promoter which is a size variant of SEQ ID NO: 1 comprising a contiguous fragment of SEQ ID NO: 1 that has a length of at least 500 bp and includes the 3? terminus of SEQ ID NO: 1 wherein the size variant has at least 80% sequence identity to the contiguous fragment of SEQ ID NO: 1, which pCS1 promoter is operably linked to a nucleotide sequence encoding a protein of interest (POI), which pCS1 promoter is not natively associated with the nucleotide sequence encoding the POI.
US Pat. No. 10,428,125

CYSTINE KNOT SCAFFOLD PLATFORM

Genentech, Inc., South S...

1. A peptide that binds to vascular endothelial growth factor A (VEGF-A), and comprises the scaffold structure:Z1C1L1C2L2C3L3C4L4C5L5C6Z2 wherein:Z1 corresponds to the N-terminus of the peptide and is selected from the group consisting of: G, no amino acid, and X, wherein X is acetylglycine or PEG6-propargylglycine;
Z2 corresponds to the C-terminus of the peptide and is selected from the group consisting of G, no amino acid, L-serine, D-serine, X, wherein X is selected from the group consisting of: L-beta-homoserine, L-beta-alanine, N-alpha-methyl-glycine, glycine comprising amidated carboxyl group, glycine ester of glycerol, glycine ester of glycol, glycine ester of oxetane-3-yl, glycine amide, and glycine morpholine amide, GFH, GIA, GGS, GTR, GVH, GLS and amino acids 30-33 of any one of SEQ ID NOs: 369-378;
C1-C6 are cysteine residues; and
L1 is loop 1 , L2 is loop 2 , L3 is loop 3 , L4 is loop 4 , and L5 is loop 5;whereinL1 is selected from the group consisting of SEQ ID NOs: 33, 141, 143, 212, 213, 277, 396-404, 414, 416, 433, 434, and amino acids 3 to 8 of SEQ ID NO: 548;
L2 is selected from the group consisting of SEQ ID NO: 97, 418, and amino acids 12-16 of SEQ ID NOs: 538, 539, 540, and 541;
L3 is selected from the group consisting of LAG, LQQ, VER, MSD, MNQ, MQT, VYQ, FIN, VSQ, VTE, FYE, MEQ, LEQ, VYR, VSD, VSE, VSK, VSN, VSX, wherein X is ornithine, LAK, MED, MEE, MEK, MEN, and MEX wherein X is ornithine, LAX wherein X is ornithine, LSG, LTG, LEG, and XAG wherein X is selected from the group consisting of: t-butyl-L-alanine, cyclobutyl-L-alanine, cyclopentyl-L-alanine, and 5,5,5-trifluoro-L-leucine, and XEQ wherein X is selected from the group consisting of: norleucine, t-butyl-L-alanine, and cyclobutyl-L-alanine;
L4 is selected from the group consisting of: V, L, I, and X wherein X is selected from the group consisting of: norleucine, butyl-L-glycine, t-butyl-L-alanine, L-cyclopentylglycine, cyclopentyl-L-alanine, cyclobutyl-L-glycine, cyclobutyl-L-alanine, and 5,5,5-trifluoro-L-leucine; and
L5 is selected from the group consisting of SEQ ID NOs: 45, 220, 427, and 429; and
wherein C1 forms a disulfide bond with C4, C2 forms a disulfide bond with C3, and C5 forms a disulfide bond with C6.
US Pat. No. 10,426,846

OLIG1 MINI-PROMOTERS: PIE305

University of British Col...

1. An isolated polynucleotide comprising an OLIG1 mini-promoter wherein the OLIG1 mini-promoter comprises one or more OLIG1 regulatory elements with at least 95% sequence identity to one, two or all of SEQ ID NOs: 3-5 operably joined to an OLIG1 basal promoter with at least 95% sequence identity to SEQ ID NO: 2 through a non-native spacing between the regulatory elements and the basal promoter, wherein the OLIG1 mini-promoter has at least 95% sequence identity to SEQ ID NO: 1.
US Pat. No. 10,428,126

DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES

The Regents of the Univer...

1. An antimicrobial peptide (AMP) comprising the amino acid sequence selected from the group consisting of: ALWMTLKKKVLKAKAKALNAVLKGANA (SEQ ID NO: 16); ALWMTLKKKVLKAKAKALNAVLAGVNA (SEQ ID NO: 17); and ALWMTLKKKVLKAKAKALNAVLVGLNA (SEQ ID NO: 19)or a pharmaceutically-acceptable salt thereof.
US Pat. No. 10,428,198

ULTRAVIOLET LIGHT ABSORBING MATRIX-MODIFIED LIGHT STABILIZING SILICA PARTICLES

International Business Ma...

1. A silica particle comprising:a silica matrix having an ultraviolet (UV) light absorbing material incorporated into the silica matrix; and
a light stabilizer material bonded to a surface of the silica matrix, the light stabilizer material comprising 4-(3-(dimethoxy(methyl)silyl)propoxy)-2,2,6,6-tetramethylpiperidine bonded to the surface of the silica matrix.
US Pat. No. 10,428,230

SYNERGISTIC MIXED SOLVENTS-BASED COMPOSITIONS WITH IMPROVED EFFICIENCY OF PERFORMANCE AND ENVIRONMENTAL SAFETY FOR REMOVAL OF PAINT, VARNISH AND STAIN

1. A non-aqueous composition for removing a paint or varnish coating from wood, metal or concrete surfaces which consists essentially of a mixture of environmentally acceptable mixed polar solvents consisting essentially of a first environmentally acceptable polar solvent selected from the group consisting of an ester amide, a lactone, an organic carbonate, a dialkyl sulfoxide, an alkyl imidazolidinone, an arylalkyl alcohol, and mixtures thereof, and a second environmentally acceptable polar solvent selected from the group consisting of an ester amide, a lactone, an organic carbonate, a dialkyl sulfoxide, an alkyl imidazolidinone, an arylalkyl alcohol, and mixtures thereof, wherein each of the first and second solvents have a Hansen's fractional polar solubility parameter component of greater than about 0.16 or 16% and at least one of the first or second solvents has a Hansen's fractional polar solubility parameter component of greater than about 0.25 or 25%; an activator; and optionally one or more additional environmentally acceptable polar solvents and optionally one or more additives chosen from rheology modifiers, bittering agents, fragrance, diluents, and/or emulsifiers, wherein the relative amounts of the first and second solvents are sufficient to cause an increase in the removal of coating of at least 5 percent compared to a composition containing either of the first or second solvents alone, and wherein the composition is devoid of N-methyl pyrrolidone.
US Pat. No. 10,431,325

METHODS TO IDENTIFY AMINO ACID RESIDUES INVOLVED IN MACROMOLECULAR BINDING AND USES THEREFOR

NOVARTIS AG, Basel (CH) ...

1. An in vitro method of producing a protein variant which exhibits increased binding to a macromolecule, the method comprisingreplacing or deleting one or more hot-spot amino acid residues in the protein by site-directed mutagenesis, wherein binding affinity of the modified protein to a macromolecule is increased, as compared to a corresponding protein lacking the replacement or deletion of one or more hot-spot amino acid residues,
(i) wherein the one or more hot-spot amino acid residues were identified using a computer-implemented method for predicting hot-spot amino acid residues of the protein, or portion thereof,
wherein the protein, or portion thereof, was represented in a structural model comprising a plurality of amino acid residues, and wherein
(i) a cluster of highly hydrophobic amino acid residues was selected from the plurality of amino acid residues of the model, wherein the cluster comprised two or more amino acid residues each having an effective-hydrophobicity greater than a chosen threshold, and wherein each amino acid residue in the cluster was within a first defined distance of at least one other amino acid residue in the cluster;
(ii) one or more solvent-exposed polar amino acid residues within a second defined distance of at least one amino acid residue in the cluster of highly hydrophobic amino acid residues was selected from the plurality of amino acid residues of the model;
(iii) amino acid residues that did not meet a criterion for evolutionary conservation were removed from the cluster of highly hydrophobic amino acid residues and from the one or more solvent-exposed polar amino acid residues, to produce a set of one or more predicted hot-spot amino acid residues; and
(iv) the one or more predicted hot-spot amino acid residues were stored;
wherein, if the hot-spot amino acid residue is replaced and is in the cluster of highly hydrophobic amino acid residues, it is replaced with an amino acid residue which is more hydrophobic such that the binding affinity is increases, or if the hot-spot amino acid residue is replaced and is from the one or more solvent-exposed polar amino acid residues, it is replaced with an amino acid residue which is more hydrophilic such that the binding affinity is increases.
US Pat. No. 10,427,995

MOLECULAR SIEVES MEDIATED UNSATURATED HYDROCARBON SEPARATION AND RELATED COMPOSITIONS, MATERIALS, METHODS AND SYSTEMS

CALIFORNIA INSTITUTE OF T...

1. A sieved hydrocarbon mixture obtained by separating an eight-membered monocyclic unsaturated hydrocarbon from a hydrocarbon mixture further comprising additional nonlinear unsaturated C8H2m hydrocarbons with 4?m?8,wherein separating the eight-membered monocyclic unsaturated hydrocarbon comprises
providing a 10-ring pore molecular sieve having a sieving channel with a 10-ring sieving aperture with a minimum crystallographic free diameter greater than 3 ? and a ratio of the maximum crystallographic free diameter to the minimum crystallographic free diameter between 1 and 2,
the 10-ring pore molecular sieve having a T1/T2 ratio?20:1 wherein T1 is an element independently selected from Si and Ge or a combination thereof, and T2 is an element independently selected from Al, B and Ga or a combination thereof,
the 10-ring pore molecular sieve further having a counterion selected from NH4+, Li+, Na+, K+ and Ca++ or a combination thereof, and
contacting the hydrocarbon mixture with the 10-ring pore molecular sieve at a temperature of ?20° C. to 60° C. for a time and under conditions to obtain a sieved hydrocarbon mixture comprising the eight-membered monocyclic unsaturated hydrocarbon at a separation concentration Cs>Ci,
wherein the 10-ring pore molecular sieve has a framework type selected from group consisting of MEL, TUN, IMF, MFI, OBW, MFS and TER, and
wherein, the sieved hydrocarbon mixture comprises the eight-membered monocyclic unsaturated hydrocarbon at a separation concentration Cs?99.3% wt.
US Pat. No. 10,428,251

TWO-PART POLYURETHANE ADHESIVES MADE USING ISOCYANATE-TERMINATED QUASI-PREPOLYMERS BASED ON POLY(BUTYLENE OXIDE)

Dow Global Technologies L...

1. A two-component polyurethane adhesive composition having a polyol component and an isocyanate component, wherein:the polyol component includes:
a) at least 35 weight percent, based on the weight of the polyol component, of one or more polyether polyols having a hydroxyl equivalent weight of 400 to 2000 and a nominal hydroxyl functionality of 2 to 4, which polyether polyols(s) are selected from homopolymers of propylene oxide and copolymers of 70 to 99% by weight propylene oxide and correspondingly 1 to 30% by weight ethylene oxide;
b) 5 to 20 parts by weight, per 100 parts by weight of ingredient a) of the polyol component, of one or more diol chain extenders;
c) 0.1 to 3 parts by weight, per 100 parts by weight of ingredient a) of the polyol component, of at least one compound having at least two primary and/or secondary aliphatic amine groups;
d) a catalytically effective amount of at least one urethane catalyst; and
e) up to 60 weight percent, based on the weight of the polyol component, of at least one particulate filler;
and the polyisocyanate component includes:
15 to 60 weight percent, based on the weight of the polyisocyanate component, of at least one isocyanate-terminated poly(butylene oxide) prepolymer having at least 2 isocyanate groups per molecule and an isocyanate equivalent weight of 700 to 3500, a poly(butylene oxide) segment having a weight of 1000 to 6000 g/mol;
20 to 50 weight percent, based on the weight of the polyisocyanate component, of at least one polyisocyanate compound having an isocyanate equivalent weight of up to 350 and 2 to 4 isocyanate groups per molecule; and
up to 50% by weight of at least one particulate filler;
wherein the isocyanate equivalent weight of the polyisocyanate component and the equivalent weight per isocyanate-reactive group of the polyol component are such that when the polyisocyanate component and the polyol component are mixed at a 1:1 ratio by volume the isocyanate index is 1.1 to 1.8.
US Pat. No. 10,426,716

COMPOSITIONS AND METHODS FOR IMPROVING COLOR DEPOSIT AND DURABILITY OF COLOR IN ARTIFICIALLY COLORED HAIR

1. A hair coloring composition comprising, in a cosmetically acceptable solvent:(a) above 0 wt. % to about 50 wt. % of one or more divalent metal salts of an inorganic acid chosen from salts of calcium, zinc, iron, nickel, copper, silver, magnesium, strontium, barium, manganese, cobalt, and mixtures thereof;
(b) above 0 wt. % to about 50 wt. % of one or more monovalent or divalent metal salts of an organic acid, wherein
the one or more divalent metal salts of an organic acid are chosen from salts of calcium, zinc, iron, nickel, copper, silver, magnesium, strontium, barium, manganese, cobalt, and mixtures thereof,
the one or more monovalent metal salts of an organic acid are chosen from salts of lithium, sodium, potassium, copper, silver, and mixtures thereof, and
the organic acid of the one or more monovalent or divalent metal salts of an organic acid is chosen from C1 to C9 monocarboxylic or di-carboxylic acids, polycarboxylic acids, hydroxy-carboxylic acids, and fatty acids having at least 10 carbon atoms; and
(c) one or more colorants chosen from oxidative dye precursors, direct dyes, pigments, and mixtures thereof.
US Pat. No. 10,427,996

FERMENTATION HYDROCARBON GAS PRODUCTS SEPARATION VIA MEMBRANE

Braskem S.A., Camacari (...

1. A method of separating and purifying a fermentation product directly from a fermenter off-gas containing the fermentation product, volatile impurities and bio-byproduct impurities, comprising the steps of: (a) compressing the fermenter off-gas to produce a compressed off-gas on a multi-stage compressor system wherein the bio-byproduct impurities and water are removed, and feeding the compressed off-gas into at least one membrane module comprising a membrane, and (b) selectively permeating the volatile impurities through the membrane, resulting in a retentate stream rich in the fermentation product.
US Pat. No. 10,428,252

TWO-COMPONENT COMPOSITION

SIKA TECHNOLOGY AG, Baar...

1. A composition comprising a first component and a second component, comprisingat least one silane group-containing polymer, liquid at room temperature,
at least one liquid epoxy resin,
at least one polyetheramine, and
at least one amino- or mercaptosilane,
the polyetheramine and the amino- or mercaptosilane not being present in the same component as the liquid epoxy resin, and
90% or more of groups reactive with an epoxide group are from the at least one polyetheramine and the at least one amino- or mercaptosilane.
US Pat. No. 10,426,719

ORAL CARE COMPOSITIONS AND METHODS FOR WHITENING TEETH

Colgate-Palmolive Company...

1. An oral care composition, comprising:a perhydrolase enzyme that catalyzes the generation of peracetic acid between a source of hydrogen peroxide and an acyl donor, wherein the enzyme comprises an amino acid sequence comprising a CE-7 signature motif and has at least 80% amino acid sequence identity to SEQ ID NO: 1 or the enzyme comprises a CE-7 signature motif that aligns with SEQ ID NO: 2, the CE-7 signature motif comprising a) an RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2: b) a GXSQG (SEQ ID NO: 3) motif at positions corresponding to positions 179-183 of SEQ ID NO: 2 and an HE motif at positions corresponding to positions 298-299 of SEQ ID NO:2; and
an anhydrous matrix configured to at least partially stabilize the perhydrolase enzyme, wherein the anhydrous matrix comprises said source of hydrogen peroxide, said acyl donor, a non-aqueous anhydrous liquid, and a thickener;
wherein the non-aqueous anhydrous liquid comprises a polyethylene oxide-polypropylene oxide block copolymer;wherein the oral care composition is a single phase composition.
US Pat. No. 10,427,999

PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE

HONEYWELL INTERNATIONAL I...

1. A composition comprising (i) at least 50% by weight 1,1,1,2,3-pentafluoropropane (245eb), (ii) 1,1,1,2,3,3-hexafluoropropane (236ea) and (iii) 1,2,3,3,3-pentafluoropropene (1225ye), wherein the composition comprises less than 2% by weight each of 1,1,1,2,3,3-hexafluoropropane (236ea) and 1,2,3,3,3-pentafluoropropene (1225ye).
US Pat. No. 10,426,720

FILM COMPOSITIONS FOR ORAL USE

Colgate-Palmolive Company...

1. An oral care composition comprising:(i) flakes of a water dissolvable or soluble film comprising:
(a) about 15 to about 40% by weight of a water soluble cellulose polymer in the form of a polymer matrix, wherein the cellulose polymer is hydroxypropylmethyl cellulose; and
(b) a dye which is entrapped in a silica sol-gel, wherein the silica sol-gel is entrained in the polymer matrix, and
(c) betaine; and
(ii) an orally acceptable carrier vehicle,
wherein the film flakes are single-layer film flakes and are pliable;
wherein the hydroxypropylmethyl cellulose is a blend of a first hydroxypropylmethyl cellulose having a viscostity ranging from 4 to 6 mPas, and a second hydroxypropylmethyl cellulose having a viscosity ranging from 40 cps to 60 mPas; and
wherein the first and second hydroxylpropylmethyl cellulose are present in a weight ratio of about 1:1.
US Pat. No. 10,426,722

COMPOSITIONS CONTAINING AN ALKYLATED SILICONE ACRYLATE COPOLYMER

1. A liquid lip composition, comprising:at least one alkylated silicone acrylate copolymer in an amount of from about 20% to about 50% by weight based on a total weight of the composition;
at least one coloring agent, and
at least one non-volatile oil in an amount of from about 5% to 60% by weight based on the total weight of the composition,
wherein the composition is anhydrous and has a gloss value at 20° angle of 10 or greater.
US Pat. No. 10,426,979

AEROSOL HAIRSPRAY PRODUCT FOR STYLING AND/OR SHAPING HAIR

The Procter and Gamble Co...

1. An aerosol hairspray product for styling and/or shaping hair wherein the product comprises:i. a container comprising a container wall which encloses a reservoir for storing a hairstyling formulation and a propellant;
ii. the hairstyling formulation comprising:
(a) from about 50% to about 99% water by total weight of the hairstyling formulation and propellant;
(b) from about 2% to about 12% of a neutralized hairstyling polymer by total weight of the hairstyling formulation and propellant, wherein the neutralized hairstyling polymer is an acrylate co-polymer;
(c) less than 0.5% of a cationic surfactant by total weight of the hairstyling formulation and propellant; and
iii. a propellant, wherein the propellant is dimethylether; and
iv. a spraying device attached to the container for dispensing the hairstyling formulation from the reservoir of the container;
wherein the hair styling formulation is free of ethanol; and
wherein the hairstyling formulation is fully dissolved.
US Pat. No. 10,426,726

MEDICAL CHEWING GUM

1. A medical chewing gum comprising gum base components, chewing gum components, gum base polymers as part of the gum base components and nicotine,wherein the gum base polymers of the chewing gum are synthetic,
the gum base polymers comprising a combined amount of polyvinyl acetate and vinyl laurate-vinyl acetate copolymer of more than 90% by weight of the gum base polymers,
wherein the combined amount of polyvinyl acetate and vinyl laurate-vinyl acetate copolymer includes 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, and
wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin,
whereby nicotine release is increased compared to a conventional nicotine chewing gum comprising natural resins having a similar level of burning.
US Pat. No. 10,428,262

NANOPARTICLE MODIFIED FLUIDS AND METHODS OF MANUFACTURE THEREOF

BAKER HUGHES, A GE COMPAN...

1. A nanoparticle modified fluid comprising:first nanoparticles that are surface modified to increase a viscosity of the nanoparticle modified fluid and that have at least one dimension that is less than or equal to about 100 nanometers;
second nanoparticles that are surface modified to increase a viscosity of the nanoparticle modified fluid and that have at least one dimension that is less than or equal to about 100 nanometers, the first nanoparticles being different from the second nanoparticles, the first and second nanoparticles having different functional groups, wherein the first nanoparticles are surface modified with epoxy groups and the second nanoparticles are surface modified with carboxyl groups; and
a liquid carrier comprising water;
wherein
the first and second nanoparticles each independently comprises carbonaceous nanoparticles, metal oxide nanoparticles, metal nanoparticles, polyhedral oligomeric silsesquioxane nanoparticles, clay nanoparticles, silica nanoparticles, boron nitride nanoparticles or a combination comprising at least one of the foregoing nanoparticles provided that where at least one of the first and second nanoparticles are the carbonaceous nanoparticles comprising carbon nanotubes, graphite nanoparticles, graphene nanoparticles, fullerenes, or a combination comprising at least one of the foregoing carbonaceous nanoparticles;
at least one of the first and second nanoparticles has an aspect ratio greater than 5;
the nanoparticle modified fluid exhibits a viscosity above that of a comparative nanoparticle modified fluid that contains the same nanoparticles but whose surfaces are not modified, when both nanoparticle modified fluids are tested at the same shear rate and temperature; and
the sum of the weight of the first and second nanoparticles is about 0.1 to about 2 wt. %, based on the total weight of the nanoparticle modified fluid, and the nanoparticle modified fluid has a viscosity increase of about 2 to about 6 orders of magnitude when the shear rate is decreased from 1,000 seconds?1 to 0.1 second?1.
US Pat. No. 10,426,728

SYNERGISTIC LIPOSOMAL FORMULATION FOR THE TREATMENT OF CANCER

Council of Scientific and...

1. A synergistic liposomal formulation for the treatment of cancer, wherein said synergistic liposomal formulation consists of drug-free phosphatidylcholine (PC) and stearylamine (SA) liposomes, and camptothecin (CPT), doxorubicin (DOX), or combinations thereof, and wherein phosphatidylcholine, stearylamine, and camptothecin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.7(CPT) or wherein phosphatidylcholine, stearylamine, and doxorubicin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.5(DOX).
US Pat. No. 10,428,521

MASONRY BLOCK HAVING A CAVITY WEB

King Fahd University of P...

1. A masonry block with a cavity web, comprising:5-10 wt % cement;
75-80 wt % of an aggregate, which is not crumb rubber;
5-8 wt % water;
5-10 wt % crumb rubber relative to the total weight of the masonry block;
wherein the crumb rubber is in the form of coarse particles having a particle size of 1.5-5 mm, fine particles having a particle size of 50-250 ?m, or a mixture of the coarse particles and the fine particles; and
at least one of cement kiln dust and limestone powder, wherein the limestone powder has an average particle size of from 1 to 50 ?m,
wherein the aggregate is at least one selected from the group consisting of a crushed recycled concrete material and crushed limestone having an average particle size of greater than 1 millimeter, and
wherein the masonry block has a rectangular form with a front face, a back face, a first end face and a second end face forming a face perimeter surrounding a plurality of interior cavities separated by a web.
US Pat. No. 10,431,851

NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY AND METHOD FOR MANUFACTURING THE SAME

NISSAN MOTOR CO., LTD., ...

1. A non-aqueous electrolyte secondary battery comprising a power generating element including:two electrodes having different polarities, each of the electrodes including an active material layer formed on a current collector; and
an electrolyte layer positioned between the electrodes,
wherein the active material layer of at least one of the electrodes contains an active material and a conductive member made from an electron conducting material,
the active material layer has a first principal surface which comes into contact with the electrolyte layer, and a second principal surface which comes into contact with the current collector,
at least a part of the conductive member forms a conductive path electrically connecting the first principal surface to the second principal surface, and the conductive path is in contact with the active material in a periphery of the conductive path,
at least a part of a surface of the active material is coated with a coating agent that includes a coating resin and a conduction assisting agent,
an electrolyte solution contained in the electrolyte layer or the electrodes is a gel phase electrolyte,
the coating resin has a tensile elongation at break of 10% or more in a saturated liquid absorption state, and
the active material layer of at least one of the electrodes does not contain a binder.
US Pat. No. 10,426,731

METHODS OF PROCESSING FETAL SUPPORT TISSUES, FETAL SUPPORT TISSUE POWDER PRODUCTS, AND USES THEREOF

TISSUETECH, INC., Miami,...

1. A fetal support tissue powder product produced by a process consisting essentially of:a) first, lyophilizing a fetal support tissue comprising amniotic membrane, chorion, or a combination thereof from frozen or previously frozen placenta to produce lyophilized fetal support tissue; and
b) second, grinding the lyophilized fetal support tissue to generate a fetal support tissue powder product.
US Pat. No. 10,428,271

COMPOSITIONS AND METHODS FOR SELECTIVELY ETCHING TITANIUM NITRIDE

Entegris, Inc., Billeric...

1. A composition comprising: at least one oxidizing agent, an etchant, at least one activator present in an amount ranging from about 0.01 percent to about 10 percent by weight, and at least one solvent, wherein the at least one activator comprises a species selected from the group consisting of acetic acid, ammonium acetate, sodium acetate, potassium acetate, phosphonium acetate, ammonium butyrate, ammonium trifluoroacetate, amino acids, phosphoric acid, diammonium monohydrogen phosphate, ammonium dihydrogen phosphate, bis(tetramethylammonium) monohydrogen phosphate, disodium monohydrogen phosphate, sodium dihydrogen phosphate, dipotassium monohydrogen phosphate, potassium dihydrogen phosphate, ditetraalkylammonium monohydrogen phosphate, ditetraalkylammonium dihydrogen phosphate, diphosphonium monohydrogen phosphate, phosphonium dihydrogen phosphate, ammonium phosphonate, sodium phosphonate, potassium phosphonate, phosphonium phosphonate, and combinations thereof, wherein when in contact with a surface of a microelectronic device, the composition selectively removes titanium nitride and/or photoresist material from the surface of the microelectronic device without removing low-k dielectric material.