US Pat. No. 10,426,279

BOLSTER PILLOW

1. A bolster pillow comprises:an internal rigid tube;
a cushioned sleeve;
an internal cover;
an external cover;
the internal rigid tube being enveloped by the internal cover;
the internal cover extending from a first end of the internal rigid tube to a second end of the internal rigid tube;
the cushioned sleeve being concentrically positioned with the internal rigid tube;
the cushioned sleeve being positioned about the internal cover, opposite the internal rigid tube;
the cushioned sleeve being attached to the internal cover; and
the internal rigid tube, the internal cover, and the cushioned sleeve being tensionably enveloped by the external cover.

US Pat. No. 10,426,277

INFLATABLE UNDER THE BED FILLER

1. A method of filling a space under a bed comprising the steps of:providing a membrane comprising a top layer, a bottom layer, and an outer sidewall joining the top layer and the bottom layer together, wherein an internal pocket capable of receiving and retaining a gas is formed within the membrane;
placing the membrane underneath a bed frame;
inflating the internal pocket until the membrane expands and occupies a majority of the space under the bed.

US Pat. No. 10,426,274

POCKETED SPRING ASSEMBLY COMPRISING STRINGS OF SPRINGS HAVING NON-LINEAR SEPARATING SEAMS

1. A bedding or seating product comprising:a pocketed spring assembly comprising a plurality of parallel strings of springs joined to each other, each of the strings of springs comprising a plurality of interconnected pockets, each of the pockets containing at least one spring encased in fabric, the fabric being joined to itself along a longitudinal seam,
wherein adjacent individually pocketed springs are separated from each other by first and second separating seams joining opposed first and second plies, each of the separating seams comprising a generally U-shaped end portion and a linear portion extending inwardly from the generally U-shaped end portion, wherein the fabric is folded downwardly from an upper surface of the string of springs towards a lower surface of the string of springs within the generally U-shaped end portion of the first separating seam, and the fabric is folded upwardly from the lower surface of the string of springs towards the upper surface of the string of springs within the generally U-shaped end portion of the second separating seam;
cushioning materials on at least one side of the pocketed spring assembly; and
an upholstered covering encasing the pocketed spring assembly and cushioning materials.

US Pat. No. 10,426,270

FOLDING CHAIR HAVING SUNSHADE

1. A folding lounge chair comprising:a rectangular seat section having a frame of two transverse rods separated by two parallel coextensive longitudinal rods and a pliant panel extending across the frame;
a leg extensions section having a rectangular frame rotatably attached to the rectangular seat section by one or more hinges;
a back section having a rectangular frame having to parallel coextensive longitudinal rods and a distal transverse rod, with a pliant panel of material extending over the frame;
a panel section having to coextensive lateral longitudinal rods and a panel of pliant material extending between them, the panel section being located between and pivotally attached to the seat section and the back section;
a stand affixed to the back of the back section that allows adjustments of the position of the back section relative to the panel section;
a canopy having a campus extending over five ribs, the ribs being joined to straps on both of the longitudinal rods of the panel section and capable of being spread over at least a portion of the back section, the panel section and the seat section;
two shoulder straps on the back of the back section.

US Pat. No. 10,426,268

FURNITURE CUSHION

1. A furniture cushion comprising:a cushion frame having a central opening;
a webbing sheet secured to a bottom surface of the cushion frame to define a cavity inside the opening of the cushion frame;
a matrix of pocketed springs supported by the webbing sheet inside the central opening of the cushion frame, the matrix of pocketed springs comprising strings of individually pocketed springs, adjacent strings being glued together, the matrix being at least partially in the cavity and extending above the cushion frame to create a crown;
a foam piece overlaying the matrix of pocketed springs and having an upper surface and a lower surface, the lower surface of the foam piece being secured directly to a top surface of the cushion frame and the upper surface of the foam piece being bowed upwardly;
a cover secured to the bottom surface of the cushion frame and extending over the foam piece.

US Pat. No. 10,426,265

CONVERTIBLE VEHICLE HAVING A TRANSPORTATION MODE AND A FIXATION MODE

1. A convertible vehicle having a transportation mode and a fixation mode, comprising:a framework assembly comprising a first framework unit and a second framework unit pivotally connected to each other;
a plurality of wheels being connected to the framework assembly and being all configured in one of the first framework unit and the second framework unit; and
a carrier member pivotally connected to the framework assembly;wherein in the transportation mode of the convertible vehicle, the first framework unit and the second framework unit are folded to form a horizontal platform, each of the wheels is located at a lower surface of the first framework unit or the second framework unit and located at a horizontal plane for transportation, and the carrier member is placed on the horizontal platform for carrying objects; andwherein in the fixation mode of the convertible vehicle, the first framework unit and the second framework unit are unfolded to be inclined and to form an X-shape structure, each of the wheels is located at the lower surface of the inclined first framework unit or the inclined second framework unit, and the carrier member is placed on a top of the X-shape structure for placing objects.

US Pat. No. 10,426,264

PORTABLE ORGANIZER SYSTEM

1. A portable organizer system, comprising:a base member;
a central vertical member having a longitudinal axis, the central vertical member coupled to the base member at a lower end of the central vertical member;
a plurality of receivers attached to the central vertical member, wherein each receiver in the plurality of receivers comprises:
a back planar element adapted to couple to the central vertical member and having a lower edge which is transverse to a direction of the longitudinal axis of the central vertical member,
an angled planar element having an upper edge and a lower edge which are generally transverse to the direction of the longitudinal axis of the central vertical member, wherein the lower edge of the back planer element is coupled to the lower edge of the angled planer element;
a first side planer element coupling a first side edge of the angled planar element to a first side edge of the back planar element;
a second side planar element coupling a second side edge of the angled planar element to a second side edge of the back planar element;
wherein a first receiver in the plurality of receivers is positioned such that the first receiver laterally opposes a second receiver with respect to the longitudinal axis, and both the first receiver and second receiver are positioned at a first substantially equal longitudinal distance along the longitudinal axis;
wherein a third receiver in the plurality of receivers is positioned such that the third receiver laterally opposes a fourth receiver with respect to the longitudinal axis, and both the third receiver and fourth receiver are positioned at a second substantially equal longitudinal distance along the longitudinal axis and above the first and second receivers with respect to the longitudinal axis and the base member;
wherein the third and fourth receivers are longitudinally positioned such that the lower edge of each angled planar element of the third and fourth receivers are longitudinally lower than the upper edge of each angled planar element of the first and second receivers, respectively; and
a handle rotatably coupled to a top portion of the central vertical member such that the handle rotates from a first position wherein a longitudinal axis of the handle is generally parallel to the longitudinal axis of the central vertical member to a second position where the longitudinal axis of the handle is generally perpendicular to the longitudinal axis of the central vertical member and wherein the handle cannot rotate past the second position.

US Pat. No. 10,426,260

ADJUSTABLE HEIGHT DESK HAVING A DEPLOYABLE FLOOR MAT

1. A desk, comprising:a tabletop;
at least one base member supporting the tabletop, the at least one base member being slidably movable between a sitting position and a standing position;
a connection bar rotatably coupled to the at least one base member;
a footrest coupled to and displaced from the connection bar, the footrest rotatable with the connection bar between a stowed position toward a back of the desk and a deployed position toward a front of the desk;
at least one mechanism disposed on the at least one base member and operatively coupled to the footrest, the at least one mechanism rotating the footrest between the stowed and deployed positions while moving the base member between the sitting position and the standing position; and
a floor mat coupled to the connection bar, wherein rotation of the footrest and the connection bar causes movement of the floor mat between a stowed mat position and a deployed mat position.

US Pat. No. 10,426,259

ADJUSTABLE HEIGHT TABLE

Varidesk, LLC, Coppell, ...

1. A table, comprising:a table top including an upper surface and a lower surface;
a first guide track and a second guide track located on the lower surface of the table top;
a first leg pivotally connected to a second leg, the first leg comprising a first slide adapted to slidably engage the first guide track, and the second leg comprising a second slide adapted to slidably engage the second guide track; and
a first retainer adapted to engage the first slide and the first guide track to prevent sliding of the first slide with respect to the first guide track, and a second retainer adapted to engage the second slide and the second guide track to prevent sliding of the second slide with respect to the second guide track,
wherein, when engaged, the first slide only engages the first guide track and the second slide only engages the second guide track, and
wherein the first slide engages the first guide track independently of the second slide engaging the second guide track.

US Pat. No. 10,426,255

ORAL CARE INSTRUMENT

Colgate-Palmolive Company...

1. A toothbrush comprising:a base component comprising
a gripping region, and
an oral engaging region defining a longitudinal axis along a length of the oral engaging region and a transverse axis along a width of the oral engaging region;
wherein the oral engaging region has a front side, the oral engaging region having bilateral symmetry with respect to a plane extending along the longitudinal axis perpendicular to the front side of the oral engaging region and comprises a distal region having an outer surface with a convex contour, the distal region gradually tapering to a middle region having an outer surface with a concave contour, the middle region gradually widening to a proximal region having an outer surface with a convex contour;
wherein a plurality of cleaning elements extend from the front side of the oral engaging region, wherein a portion of the plurality of cleaning elements are longest in length as measured from the front side to the oral engaging region at least near a distal end of the oral engaging region; and
wherein the plurality of cleaning elements are formed in a trim profile that approximately matches a shape of a lateral side of the oral engaging region such that a length of the plurality of cleaning elements in the distal and proximal regions is greater than a length of the plurality of cleaning elements in the middle region, the plurality of cleaning elements gradually decreasing in length from the distal end and a proximal end of the oral engaging region towards the middle region.

US Pat. No. 10,426,254

SYSTEMS AND METHODS FOR PROVIDING ANGLE GUIDANCE FOR A USER OPERATING AN ORAL HYGIENE DEVICE

KONINKLIJKE PHILIPS N.V.,...

1. An oral hygiene device, comprising:a longitudinal shaft defining a longitudinal axis;
an attachment assembly located at a first end of the longitudinal shaft, the attachment assembly for contacting a contact surface in a user's mouth;
a handle portion comprising:
a portion of the longitudinal shaft comprising a second end of the longitudinal shaft;
a force sensor operable to detect an amount of side force applied to the attachment assembly, the side force comprising a force applied by the contact surface in a direction perpendicular to both the longitudinal axis and the normal of the contact surface, the force sensor comprising a suspension system having at least one elastic spring element and a predefined stiffness for motion in a first direction and a second direction, wherein the first and second direction are both perpendicular to the longitudinal axis of the longitudinal shaft;
at least one accelerometer operable to measure an amount of gravitational force applied to the attachment assembly; and
at least one processor operable to determine an angle that the attachment assembly is applied at based on the detected amount of side force.

US Pat. No. 10,426,253

CLEANING DEVICE AND ASSOCIATED OPERATING METHOD

1. A cleaning device for an atomizer, comprising:a wet cleaning station with a housing and at least one cleaning nozzle, the at least one cleaning nozzle having a cleaning trunk rotatable relative to the housing and a nozzle aperture within the housing, the at least one cleaning nozzle being configured to dispense a cleaning fluid from the cleaning trunk at the nozzle aperture,
wherein the housing is configured with an introduction aperture and to receive the atomizer therewithin through the introduction aperture and along an introduction axis, the at least one cleaning nozzle being configured to dispense the cleaning fluid on the atomizer disposed within the housing, and
wherein the cleaning trunk includes at least one counterweight, the at least one counterweight configured to balance the cleaning trunk about a rotational axis of the cleaning trunk.

US Pat. No. 10,426,252

ORAL CARE SYSTEM AND METHOD

Colgate-Palmolive Company...

1. A dispenser comprising:a housing defining a longitudinal axis;
a pressurized product tube disposed in the housing and including a reservoir containing a material;
an outlet in fluid communication with the reservoir;
a valve fluidly coupled to the outlet, the valve being movable between an open dispensing position and a closed non-dispensing position; and
a compression device disposed inside the housing of the dispenser, the compression device configured to apply pressure to the product tube for dispensing the material, wherein the compression device includes a pair of opposing pressure plates resiliently biased into engagement with opposing sides of the product tube, the plates operable to squeeze the material from the reservoir when the valve is in the open dispensing position;
wherein the valve is configured to dispense the material from the reservoir under pressure when in the dispensing position;
wherein the valve includes an orifice movable into and out of a flow path defined through the outlet; and
wherein the pressure plates are resiliently coupled together by a pair of elastomeric members each anchored to mating opposing longitudinal edges of the pressure plates along opposing lateral sides of the compression device.

US Pat. No. 10,426,251

ORAL CARE SYSTEM AND ORAL CARE MATERIAL DISPENSER

Colgate-Palmolive Company...

1. An oral care system comprising:a toothbrush;
a dispenser detachably mounted to the toothbrush, the dispenser comprising:
a housing forming an internal cavity extending along a longitudinal axis between a proximal end and a distal end;
an elevator slideably disposed within the internal cavity that separates the internal cavity into a reservoir for containing an oral care material and a chamber, the elevator including an annular sealing portion having a proximal edge, distal edge, and sidewall therebetween that forms a fluid seal with the housing, a plug portion protruding axially from the sealing portion towards the distal end of the housing, and a mounting stem portion protruding axially beyond the proximal edge of the sealing portion towards the proximal end of the housing;
a dispensing orifice at the distal end of the housing for dispensing the material from the reservoir;
an actuator rotatably coupled to the housing;
a drive screw positioned in the chamber, the drive screw non-rotatably coupled to the actuator such that rotating the actuator rotates the drive screw, wherein the drive screw does not penetrate through the elevator into the reservoir; and
a tubular extension member having a distal end detachably coupled to the elevator via a component interface and a proximal end threadably coupled to the drive screw, the extension member being non-rotatable with respect to the housing;
wherein rotation of the actuator in a first direction causes the extension member and elevator to axially advance along the drive screw towards the dispensing orifice for dispensing the material due to relative rotation between the drive screw and the extension member.

US Pat. No. 10,426,250

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle;
a head coupled to the handle, the head comprising a front surface and a longitudinal axis that extends from a proximal end of the head to a distal end of the head;
a plurality of tooth cleaning elements extending from the front surface of the head;
the plurality of tooth cleaning elements comprising a first conical tuft comprising a first bristle wall having an inner surface defining a first cavity along a first cavity axis, the first cavity having a transverse cross-sectional area that increases with distance from the front surface of the head, wherein the first bristle wall of the first conical tuft terminates in a first annular top surface that is inclined relative to the front surface from a first high point to a first low point;
the plurality of tooth cleaning elements comprising a second conical tuft comprising a second bristle wall having an inner surface defining a second cavity along a second cavity axis, the second cavity having a transverse cross-sectional area that increases with distance from the front surface of the head, wherein the second bristle wall of the second conical tuft terminates in a second annular top surface that is inclined relative to the front surface from a second high point to a second low point; and
the first and second conical tufts arranged on the head such that the first and second high points are adjacent to one another.

US Pat. No. 10,426,249

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle;
a head coupled to the handle and having a front surface;
a first tuft of cleaning elements extending from the front surface of the head along an axis and comprising a first plurality of cleaning elements formed of an elastomeric material;
a second tuft of cleaning elements extending from the front surface of the head and comprising a second plurality of cleaning elements formed of the elastomeric material;
a first sleeve coupled to the head and extending from the front surface of the head, the first sleeve circumferentially surrounding a first portion of the tuft of cleaning elements, a second portion of the tuft of cleaning elements protruding beyond a distal end of the sleeve, and the first sleeve having a first height measured from the front surface of the head to a distal end of the first sleeve; and
a second sleeve coupled to the head and extending from the front surface of the head, the second sleeve circumferentially surrounding a portion of the second tuft of cleaning elements, the second sleeve having a second height measured from the front surface of the head to a distal end of the second sleeve;
wherein the first and second heights are different when the first and second tufts of cleaning elements are in a resting state with no external forces applied.

US Pat. No. 10,426,248

COLLAPSIBLE HAIR BRUSH

1. A hair brush comprising:a head having a front portion, a rear portion and an edge portion,
said edge portion having an upper rim and a flange defining an inner channel therebetween;
said rear portion and said edge portion defining a hollow housing, said rear portion has a central opening;
said front portion having a front face, an opposite rear face, a central portion and a perimeter that engages said inner channel, and is flexible, movable between a convex configuration and a concave configuration;
said rear face has a pad at said central portion;
a handle extending from said edge portion of said head;
a plurality of bristles extending uniformly from said front face of said front portion, except at said central portion where bristles would have been present from such uniformity, there are no bristles;
wherein when said front portion is in a concave configuration, said front portion is completely within said hollow housing and said rear face of said front portion is adjacent said rear portion with said pad matingly covers said central opening of said rear portion completely, and when said front portion is in a convex configuration, said bristles are outside said hollow housing.

US Pat. No. 10,426,246

COSMETIC CONTAINER

1. A cosmetic vessel comprising:an airless pump for discharging cosmetics to outside;
a discharge plate provided at one side of the airless pump from which the cosmetics is discharged, and including a plurality of discharge holes; and
a diffusion space configured to diffuse the cosmetics between the airless pump and the discharge holes to guide the cosmetics to the discharge holes,
wherein the discharge plate is made of metal, and is exposed to outside such that it may be contacted by a user's puff, and
the cosmetics is discharged from the airless pump as the discharge plate is pressed,
wherein the discharge holes do not coincide with an outlet of the airless pump, and
wherein a sealing is achieved by a close surface contact between a diffusion unit having the diffusion space and the discharge plate, and wherein the diffusion unit is provided between the airless pump and the discharge plate.

US Pat. No. 10,426,242

PORTABLE SUPPORT FOR A BODY PART

1. A portable support for a user comprising:a) a covering including a closable opening to an inner cavity adapted to carry articles; said inner cavity comprising: a first hinge and second hinge; said first hinge creating a first pivoting wing and said second hinge creating a second pivoting wing, wherein said first and second pivoting wings pivot about said first or said second hinges toward or away from said closable opening positioned above an intermediate segment of said inner cavity positioned between and distinct from said wings; and wherein an inward side of said covering creates said inner cavity;
b)
c) one or more receptacles attached to an outward side of said covering;
said receptacles adapted to carry one or more tangibles;
d) a first connector attached to said outward side proximate said first pivoting wing and a second connector attached to said outward side proximate said second pivoting wing;
e) cushion substances attached to portions of said inward side of said covering such that a user can position said portable support against a part of said user for resting said part against said portable support; and
f) a detachable carrier adapted for connection to said first and second connectors.

US Pat. No. 10,426,239

RECEIVING DEVICE

Fu Tai Hua Industry (Shen...

1. A receiving device comprising:a casing comprising a baseboard, a first side plate, a second side plate, and a receiving member;
a guiding member received in the receiving member and defining a receiving groove used for receiving a rod-shaped object;
a rotation member rotatably covering the receiving groove and defining a bump element and a first spring, wherein the bump element is connected to the first side plate by the first spring;
a key movably arranged in the casing and having an exposed end protruding out from the casing; and
a pushrod comprising a first end contacting the key, a second end mounted on the bump element, and a spindle mounted on the casing;
wherein when the exposed end of the key is pressed, the key drives the pushrod to rotate about the spindle, and the pushrod drives the rotation member to rotate until the receiving groove is no longer covered, thus the receiving groove is made accessible.

US Pat. No. 10,426,236

MULTI-FUNCTION DOUBLE-CANOPY UMBRELLA

15. A space-saver umbrella comprising:a first post-stabilizing foot;
a second post-stabilizing foot;
a mounting plate,
bolted on said first post-stabilizing foot
and said second post-stabilizing foot
a lower post,
an upper post;
an inner core
for being attached to said mounting plate and inserted into and bolted to said lower post and said upper post, or
for mounting said upper post on a fence, a balcony, a bumper, a hitch, a tailgate, a table, a column, or a wall
by being bolted to said upper post and being wedged into said fence, said balcony, said bumper, said hitch, said tailgate, said table, said column, or said wall;
a multi-canopy-lifting-arm intersector
attached to said upper post;
a multi-canopy-supporting-arm intersector
slidably attached to said upper post;
a slidable multi-position handle
molded to said multi-canopy-supporting-arm intersector;
a height-adjusting spring-loaded rocker
sandwiched within said slidable multi-position handle;
a handle-locking rocker pin
attached to said height-adjusting spring-loaded rocker;
a plurality of handle-locking post holes respectively
drilled into said upper post;
a foldable multi-canopy-supporting arm
pivotably bolted to said multi-canopy-supporting-arm intersector;
a foldable multi-canopy-lifting arm
pivotably bolted to said multi-canopy-lifting-arm intersector and
said foldable multi-canopy-supporting arm;
a multi-canopy-hanging central tube;
a multi-canopy-deploying rope
threaded through said multi-canopy-supporting-arm intersector, and
threaded through said multi-canopy-hanging central tube;
a central-canopy intersector
attached to said multi-canopy-hanging central tube;
a plurality of central-canopy-supporting ribs respectively
attached to said central-canopy intersector;
a plurality of central-canopy-rib-raising arms respectively
pivotably attached to said central-canopy-supporting ribs;
a central canopy
attached to said central-canopy-supporting ribs;
a ring-canopy-rib intersector
connected to said multi-canopy-hanging central tube;
a plurality of first ring-canopy-supporting ribs respectively
pivotably connected to said ring-canopy-rib intersector, and
pivotably attached to said central-canopy-rib-raising arms;
a plurality of second ring-canopy-supporting ribs;
a plurality of multi-rib-connecting cores respectively
inserted into and screwed to said first ring-canopy-supporting ribs and
said second ring-canopy-supporting ribs,
a plurality of rib-length-adjusting holes respectively
drilled into said first ring-canopy-supporting ribs,
said second ring-canopy-supporting ribs, and
said multi-rib-connecting inner cores;
a ring-canopy-arm intersector
slidably attached to said multi-canopy-hanging central tube,
said multi-canopy-deploying rope
attached to said ring-canopy-arm intersector;
a plurality of ring-canopy-rib-raising arms respectively
foldably attached to said ring-canopy-arm intersector;
a ring canopy
attached to said first ring-canopy-supporting ribs and said second ring-canopy-supporting ribs,
said ring canopy having a plurality of corners and a plurality of inner edges;
four pockets respectively
sewn to said corners of said ring canopy;
a plurality of canopy-size-adjusting flaps respectively
sewn to said inner edges of said ring canopy;
a plurality of canopy-size-adjusting holes respectively
drilled into said first ring-canopy-supporting ribs.

US Pat. No. 10,426,235

PORTABLE SHADE PROVIDER

1. A shade producing apparatus comprising:a pushcart having a collapsible handle, wheels, and a load platform;
an umbrella member having a telescoping and tiltable pole; said telescoping and tiltable pole being attached to a telescoping auxiliary pole; wherein said telescoping auxiliary pole is secured to a flange base that is mounted to the load platform; wherein the load platform includes a front edge and a back edge positioned adjacent to the wheels, wherein the flange base is positioned substantially closer to the back edge than to the front edge; wherein the apparatus further comprises a double tube connector that is attached to the collapsible handle to receive the umbrella member.

US Pat. No. 10,426,233

METHOD FOR MANUFACTURING WATERPROOF FASTENER TAPE

YKK Corporation, (JP)

1. A method for manufacturing a waterproof fastener tape, the method comprising:forming a viscous waterproof layer on a releasable substrate;
attaching the viscous waterproof layer formed on the releasable substrate to a fastener tape base fabric, and peeling the releasable substrate off the viscous waterproof layer that has been attached to the fastener tape base fabric;
promoting curing of the viscous waterproof layer formed on the fastener tape base fabric to form a reduced-viscosity waterproof layer; and
after said promoting of curing of the viscous waterproof layer, covering an exposed surface of the reduced-viscosity waterproof layer formed on the fastener tape base fabric with a releasable cover.

US Pat. No. 10,426,231

MOLDED SURFACE FASTENER, CUSHION BODY, CUSHION BODY MANUFACTURING METHOD, AND MOLDING DIE

YKK Corporation, (JP)

1. A molded surface fastener that is configured to be integrated to a groove portion for fixing a skin material provided on a surface portion of a cushion body along a length direction of the groove portion at a time of foam molding of the cushion body,comprising at least one surface fastener portion in which an engaging region is formed of a plurality of hook-shaped engaging elements standing on a first surface of a flat plate-shaped substrate portion wherein:
a foldable piece portion extends from one of left and right end edge portions in a width direction which is perpendicular to the length direction of the surface fastener portion,
at least a part of the foldable piece portion has flexibility which is foldable with respect to the surface fastener portion,
the surface fastener portion has a pair of first barrier portions standing along a width direction at both end portions in a length direction of the substrate portion and between which the engaging region is disposed, and a second barrier portion standing along the length direction at an end edge portion of an opposite side of a side of the foldable piece portion in the substrate portion,
each hook-shaped engaging element has a rising portion standing from the substrate portion and a hook portion extending in the width direction from an upper end of the rising portion, and
the hook portion extends only toward a side of the foldable piece portion.

US Pat. No. 10,426,230

THREE-DIMENSIONAL SHOE MANUFACTURING

adidas AG, Herzogenaurac...

1. A method for the manufacture of a plurality of shoes, the method comprising:producing a plurality of three-dimensionally pre-shaped shoe uppers relative to a plurality of three-dimensionally shaped mounting devices, the plurality of three-dimensionally shaped mounting devices comprising at least one mounting device having a three-dimensional shape that corresponds to a first shoe model shape for a first shoe model and at least one other mounting device having a three-dimensional shape that corresponds to a second shoe model shape for a second shoe model, each respective pre-shaped shoe upper being produced by constructing a material on a corresponding one of the mounting devices, wherein at least one shoe upper of the plurality of three-dimensionally pre-shaped shoe uppers has a three-dimensional pre-shape that corresponds to the first shoe model shape and at least one other shoe upper of the plurality of three-dimensionally pre-shaped shoe uppers has a three-dimensional pre-shape that corresponds to the second shoe model shape,
processing the plurality of three-dimensionally pre-shaped shoe uppers to produce the plurality of shoes, wherein at least one shoe of the plurality of shoes is the first shoe model and at least one other shoe of the plurality of shoes is the second shoe model,
wherein the processing comprises an individually controllable succession of processing steps that proceed in an automated manner.

US Pat. No. 10,426,229

FOOTWEAR MANUFACTURING PROCESS

1. A method of manufacturing a shoe sole, the method comprising the steps:acquiring a plurality of tennis balls
grinding the tennis balls in a granulator, thereby generating felt fuzz and rubber granules;
passing said felt fuzz and rubber granules through a screen, thereby separating said rubber granules from said felt fuzz;
combining water and polyurethane, resulting in a water and polyurethane mixture;
combining said water and polyurethane mixture with said rubber granules;
mixing said rubber granules and said water and polyurethane mixture into a rubber mixture;
placing said rubber mixture into a hydraulic press;
pressing said rubber mixture into a sheet;
curing said sheet;
selecting a cut-out die, said cut-out die shaped for forming a footwear sole;
cutting a sole from said sheet with said cut-out die; and
applying said sole to a piece of footwear.

US Pat. No. 10,426,228

SHOELACE WITH MAGNETS

1. A shoelace comprising:a cord having two ends;
two aglets, one at each end of the cord; and
three or more magnets integrated within the shoelace, wherein the three or more magnets include a first magnet disposed at a first location within or adjacent to one of the two aglets, a second magnet disposed at a second location within or adjacent to the other of the two aglets, and a third magnet disposed at a centerpoint of the cord.

US Pat. No. 10,426,227

LACELESS SHOE

adidas AG, Herzogenaurac...

1. A laceless shoe upper for a shoe, the shoe upper comprising:a. a lateral portion comprising a first coating portion applied to a first base fabric portion;
b. a medial portion comprising a second coating portion applied to a second base fabric portion; and
c. an elastic intermediate portion between the lateral portion and the medial portion and comprising a cupped portion uncoated by the first coating portion and the second coating portion, wherein the cupped portion is cupped above surrounding areas of the laceless shoe upper when the laceless shoe upper is laid out in an at-rest state, wherein the cupped portion maintains its shape when the shoe is not being worn, wherein the first coating portion is adapted to modify a stiffness of the first base fabric portion of the lateral portion to be at least 2 times higher than a stiffness of the elastic intermediate portion, and wherein the second coating portion is adapted to modify a stiffness of the second base fabric portion of the medial portion to be at least 2 times higher than the stiffness of the elastic intermediate portion.

US Pat. No. 10,426,226

FOOTWEAR UPPER WITH DYNAMIC AND LOCK-OUT REGIONS

Under Armour, Inc., Balt...

1. An article of apparel comprising:a base layer; and
an auxetic layer coupled to the base layer, the auxetic layer comprising an auxetic structure defining a repeating pattern of perimeter walls and interior recesses, the auxetic layer including a first region and a second region, wherein each interior recess in the first region provides a void exposing the base layer, and wherein each interior recess in the second region is at least partially filled with a recess material.

US Pat. No. 10,426,225

SHOE WITH A HIGH HEEL TO LOW HEEL CONVERSION

High-Low Heel, LLC, Vanc...

1. An article of footwear comprising:a sole including a heel receiver having a fixed hook portion, a movable hook portion disposed opposite the fixed hook portion, and an actuator configured to move the movable hook portion between a retracted position and an extended position, wherein the actuator and the movable hook portion are formed as a single piece and are guided and retained against a bottom of the sole by a pair of side guides and a retainer bar;
a first heel portion and a second heel portion, each of the first and second heel portions having a first recess configured to engage the fixed hook portion and a second recess configured to engage the movable hook portion, such that, when the respective heel portion is engaged with the heel receiver: (a) the respective heel portion is secured to the heel receiver when the movable hook portion is in the extended position, and (b) the respective heel portion is releasable from the heel receiver when the movable hook portion is in the retracted position;
wherein the article of footwear is transitionable between a first configuration, in which the first heel portion is secured to the heel receiver portion of the sole, and a second configuration, in which the second heel portion is secured to the heel receiver portion of the sole.

US Pat. No. 10,426,222

SOLE STRUCTURE FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A sole structure for an article of footwear, comprising:an upper element;
a lower element positioned below the upper element;
a first elongated, cantilevered flexure element extending from a base element, the base element constituting at least part of one of the upper element and the lower element; and
a second elongated, cantilevered flexure element joined to an opposed element, the opposed element being at least a part of the other of the upper element and the lower element, the second flexure element extending from the opposed element toward the base element,
wherein the first and second flexure elements have a first free end and a second free end respectively, and wherein the first flexure element is configured for slidingly contacting the opposed element when a vertical compressive load is applied to the upper element.

US Pat. No. 10,426,221

METHOD AND APPARATUS FOR DYNAMICALLY ALTERING A HEIGHT OF A SOLE ASSEMBLY

NIKE, Inc., Beaverton, O...

1. An actuator assembly for an article of footwear comprising:a wedge having an anterior end, a posterior end, and an inclined upper surface extending upwardly from the anterior end to the posterior end;
a retractor connected to a rear portion of the wedge and configured to pull the wedge rearwardly within a groove formed in a sole assembly of an article of footwear; and
a spring assembly connected to a front portion of the wedge and configured to provide tension in a forward direction on the wedge positioned in the groove.

US Pat. No. 10,426,220

POINTE SHOES WITH ENHANCED IMPACT PROTECTION AND RESISTANCE TO MOISTURE DEGRADATION

1. A pointe shoe for enhancing a dancer's ability to stand on pointed toes, the pointe shoe having a tip portion, a front portion, a right side portion, a left side portion, a front bottom portion, and a rear bottom portion; the tip portion, the front portion, the right side portion, and the left side portion comprising:an outer fabric layer configured to present an attractive outer surface of the point shoe;
an outer silicone layer, attached inside the outer fabric layer, the outer silicone layer being configured to present an outer moisture barrier;
a paper mache layer, attached to the silicone layer;
a viscoelastic urethane polymer layer, attached to the paper mache layer, configured to evenly spread impact of pointed toes of the dancer;
an inner silicone layer, attached to the viscoelastic urethane polymer layer, the inner silicone layer being configured to present an inner moisture barrier to protect at least the paper mache layer from moisture; and
an inner fabric layer, attached to the inner silicone layer, configured so as to allow the toes of the dancer to breathe.

US Pat. No. 10,426,217

FOOTWEAR WITH INTERCHANGEABLE SECTIONS

1. An article of footwear, comprising:a toe portion comprising:
a toe cover secured to a first end of an upper surface of a toe plate; and,
a plurality of prong receivers disposed in a first array across a majority of a width of said toe plate and along a second end of said toe plate;
a heel portion comprising:
a heel back secured to a first end of an upper surface of a heel plate;
a heel stem secured to a lower surface of said heel plate; and,
a plurality of prongs projecting away from said heel plate and disposed in a second array across a majority of a width of said heel plate and along a second end thereof; and,
a flap removably covering said upper surface of said toe plate and said heel plate and coextensive with a width of said toe plate and said heel plate;
wherein said plurality of prongs is capable of being removably secured within said plurality of receivers thereby securing said toe portion to said heel portion;
wherein each prong receiver comprises a square-shaped opening; and
wherein each prong comprises a lengthened pyramid having a sharp distal end.

US Pat. No. 10,426,215

HELMET WITH FACEMASK ADJUSTMENT MECHANISM

SPORT MASKA INC., Montre...

1. A protective helmet comprising:a helmet body having a front portion;
a facemask extending from the front portion to cover at least a portion of a face of a wearer;
at least one adjustment mechanism securing the facemask to the helmet body, the at least one adjustment mechanism including a base defining an aperture, the at least one adjustment mechanism connected to the helmet by a fastener received through the aperture and including an engagement member engaged with the facemask, the at least one adjustment mechanism being selectively engageable with the facemask in at least two vertically spaced apart positions of the facemask relative to the helmet body, the at least one adjustment mechanism allowing toolless adjustment between the at least two vertically spaced apart positions.

US Pat. No. 10,426,214

PROTECTIVE HEAD GEAR WITH MOVEABLE MEMBERS

1. A head gear device comprising:a helmet adapted to be worn by a user, the helmet including an exterior surface and an inner surface defining a cavity adapted to be fitted on a head of the user;
at least one sensor secured to the helmet, the at least one sensor configured to measure one or more of force and motion; and
multiple moveable members coupled to the inner surface of the helmet, with one or more moveable members, selected from the multiple moveable members, configured to be controllably actuated, based on an electrical actuating control signal, to cause at least a part of each of the selected one or more moveable members to be displaced, in response to detection by the at least one sensor secured to the helmet of a detected external force component applied to the helmet, towards the head of the user such that the selected one or more moveable members move in a direction opposite an impact direction at which the detected external force component was applied to the helmet in order to apply a counterforce to the head of the user, the at least part of the each of the selected one or more moveable members being displaced with a displacement force computed from a magnitude of the detected external force component detected by the at least one sensor secured to the helmet.

US Pat. No. 10,426,213

TOTAL CONTACT HELMET

Kranos IP Corporation, L...

1. A total contact helmet, comprising a body made completely from carbon fiber capable of distributing the force of an impact to a large surface area of said body by transmitting force of impact laterally and decreasing pressure as the force is transmitted through the body, said body being a layer having an inner surface configured to be in contact with a surface of an individual's head when worn and an outer surface exposed to the environment, wherein said layer is continuously formed from said inner surface to said outer surface.

US Pat. No. 10,426,212

MODULAR FOOTBALL HELMET APPARATUS AND SYSTEM

1. A modular helmet comprising:a frame comprising a plurality of elongated ribs extending upward from a base portion, the plurality of elongated ribs defining a cranial portion, each elongated rib in the plurality of elongated ribs being spaced apart from each adjacent elongated rib in the plurality of elongated ribs such that each elongated rib in the plurality of elongated ribs is configured to independently flex upon an impact; and,
a shell being configured to be removably coupled to the frame, the shell being configured to house the frame in an interior portion of the shell.

US Pat. No. 10,426,211

HEADGEAR TO ASSIST A CHILD ON THE SHOULDERS OF THE WEARER

1. A handle headgear for securing handles to a head of a wearer so that child on a back of the wearer can grip said handles, comprising:a frame strapping dimensioned and adapted to extend laterally across the skull of a human wearer, wherein opposing ends of the frame strapping are disposed adjacent to the two ears of the human wearer; and
the frame strapping comprises two spaced apart post straps and a plurality of rung straps extending between the two spaced apart post straps;
first and second handles upwardly extending from one of the two spaced apart post straps so as to be disposed at, near, along or just adjacent to the boundary of the frontal and parietal portions of the wearer's skull, wherein the first and second handles are disposed just leftward and just rightward of a longitudinal centerline of said skull.

US Pat. No. 10,426,210

KNOTTING SYSTEM, KNOTTING METHOD, AND METHOD FOR PRODUCING WIG USING SAME

HIMO, INC., Seoul (KR)

1. A hair knotting system comprising one or more hair knotting apparatuses installed in a feeding direction of a thread and configured to knot one or more hairs to the thread, the hair knotting apparatus comprising:a hair insertion member having an insertion groove configured for the one or more hairs being inserted therein, and a pull-out hole formed on a bottom surface of the insertion groove;
a hair pull-out member for picking up and pulling out the one or more hairs, inserted in the insertion groove, through the pull-out hole so that the one or more hairs are positioned past an area under the thread, and forming a knotting hole as the thread and the one or more hairs connect;
a hair knotting member passing through the knotting hole from bottom to top so as to be positioned above the thread; and
a hair winding member for picking up both end portions of the one or more hairs pulled out from the hair insertion member, and winding both the end portions of the one or more hairs while rotating around the hair knotting member above the thread,
wherein the hair knotting member is configured to knot the one or more hairs onto the thread by pulling down, through the knotting hole, both end portions of the one or more hairs wound around a circumferential surface of the hair knotting member.

US Pat. No. 10,426,209

PROCESS FOR CREATING TRANSITORY COLORED HAIR FOR HAIR EXTENSIONS AND WIG HAIR

1. A transitory colored hair for extensions or wigs having colors that segregate longitudinal hair strands into three horizontal sections and formed by combining a hair group 1 and a hair group 2 comprising:hair group 1 consists of hair strands of a predetermined length color processed to color A;
hair group 2 consists of hair strands approximately two-thirds the predetermined length of the hair group 1 color processed to color B;
the transitory colored hair formed by combining the hair group 1, which is colored A, and the hair group 2, which is colored B, to form a combination hair 1+2;
a top one-third segment of the combination hair color processed to color C;
wherein a top segment of the combination hair is adapted to be attached near a user's scalp having hair strands of color C;
a bottom segment of the combination hair composed of terminal ends of the hair strands having color A; and
a middle segment of the combination hair having hair strands having a mixture of the color A and the color B forming the transitory colored hair.

US Pat. No. 10,426,207

CLIP APPARATUSES AND METHODS OF MAKING AND USING THE SAME

1. A system comprising:a clip apparatus comprising:
a bottom plate;
a top plate comprising an aperture;
a bridge between the bottom plate and the top plate holding the bottom plate a distance from the top plate;
a resilient frame disposed within the bottom plate, the top plate and the bridge;
a mounded protrusion extending upwardly from the bottom plate toward the top plate, wherein the mounded protrusion extends through the aperture in the top plate such that a top surface of the mounded protrusion extends above a top surface of the top plate and further wherein the top plate and the aperture within the top plate completely surround the mounded protrusion; and
a clothing article disposed over the protrusion and frictionally held in place over the protrusion, and further wherein the clothing article is pushed through the aperture of the top plate by the mounded protrusion.

US Pat. No. 10,426,206

ARTICLE OF APPAREL UTILIZING ZONED VENTING AND/OR OTHER BODY COOLING FEATURES OR METHODS

NIKE, Inc., Beaverton, O...

1. A method, comprising:wetting a garment for at least an upper torso of a wearer, wherein the garment includes a head or neck opening, a waist opening, and two arm openings, and wherein the garment includes a first portion formed of a non-mesh fabric material having an air permeability of less than 550 ft3/min per ft2 measured according to ASTM D737-96 and a second portion including a mesh vented zone extending along a center back portion of the garment, wherein the mesh vented zone has an air permeability of at least 550 ft3/min per ft2 measured according to ASTM D737-96 and has an area of at least 20 in2;
at least 20 minutes prior to a start of an event or exercise routine, wherein the event or exercise routine consists of physical activity that causes a wearer's body temperature to increase as a result of the physical activity, donning the wetted garment and wearing it in a wetted condition so as to cool a wearer's body prior to the start; and
participating in the event or exercise routine.

US Pat. No. 10,426,205

INTELLIGENT FABRIC, INTELLIGENT SHOE AND INTELLIGENT GARMENT

BOE TECHNOLOGY GROUP CO.,...

1. An intelligent fabric, comprising:a base layer provided with vent holes;
a thermal insulation layer arranged on the base layer and movable relative to the base layer;
a temperature sensor configured to detect temperature information; and
a controller connected to the temperature sensor and the thermal insulation layer, and configured to control the thermal insulation layer to be moved relative to the base layer in accordance with the temperature information detected by the temperature sensor, so as to switch the thermal insulation layer between a state where the thermal insulation layer covers the vent holes completely and a state where the thermal insulation layer does not cover the vent holes, or among the state where the thermal insulation layer covers the vent holes completely, a state where the thermal insulation layer covers a portion of the vent holes, and the state where the thermal insulation layer does not cover the vent holes,
wherein in the case that the thermal insulation layer is switched between the state where the thermal insulation layer covers the vent holes completely and the state where the thermal insulation layer does not cover the vent holes, the controller comprises:
a first comparator connected to the temperature sensor and configured to compare the temperature information detected by the temperature sensor with a temperature threshold; and
a first control unit connected to the first comparator and the thermal insulation layer, and configured to, in the case that the first comparator determines that the temperature information detected by the temperature sensor is less than or equal to the temperature threshold, control the thermal insulation layer to completely cover the vent holes, and in the case that the first comparator determines that the temperature information detected by the temperature sensor is greater than the temperature threshold, enable the thermal insulation layer not to cover the vent holes.

US Pat. No. 10,426,204

VENTILATED GARMENT

1. A ventilated garment configured to be supported on a back of a wearer, the ventilated garment comprising:an inner panel having a top edge margin, an opposite bottom edge margin, and first and second opposite side edge margins, the inner panel being shaped and arranged for extending vertically along the back of the wearer when the ventilated garment is supported on the back of the wearer such that the bottom edge margin is positioned adjacent a base of the back and the top edge margin is positioned adjacent a neck of the wearer;
an outer panel having a top edge margin, an opposite bottom edge margin, and first and second opposite side edge margins, the first and second side edge margins of the outer panel being joined to the first and second side edge margins of the inner panel such that the inner and outer panels define an air flow guide channel therebetween, the bottom edge margins of the inner and outer panels being spaced apart from one another to define an air intake adjacent the base of the back of the wearer in fluid communication with the air flow guide channel and the top edge margins of the inner and outer panels being spaced apart from one another to define an air flow outlet adjacent the neck of the user in fluid communication with the air flow guide channel, the air flow guide channel fluidly connecting the air intake to the air flow outlet; and
a blower received in the air flow guide channel and configured to draw air into the air flow guide channel through the air intake and to blow the air vertically through the air flow guide channel and out the air flow outlet thereby providing convective cooling of at least one of the neck and a head of the wearer;
wherein the bottom edge margin and the top edge margin of the outer panel each have a generally convex shape.

US Pat. No. 10,426,198

ELECTRICAL CONNECTOR FOR AN ELECTRONIC VAPING DEVICE

ALTRIA CLIENT SERVICES LL...

1. An electronic vaping device comprising:a first section having a male connector, the male connector including
at least one flange on an outer surface of the male connector, at least a portion of the flange having a substantially planar first surface,
male anode portion, and
a male cathode portion; and
a second section having a female connector, the female connector configured to engage the male connector to connect the first section to the second section, the female connector defining a circular internal recess and including,
at least one secant flange on a surface of the defined internal recess, the secant flange having a semi-disk shape and including a surface extending across the defined internal recess,
a female anode portion, and
a female cathode portion.

US Pat. No. 10,426,197

AEROSOL-GENERATING SYSTEM WITH ENHANCED AIRFLOW MANAGEMENT

ALTRIA CLIENT SERVICES LL...

1. An aerosol-generating system comprising:a liquid storage portion comprising a housing holding a liquid aerosol-forming substrate and a capillary medium, the housing having an opening; and
a fluid permeable heater assembly comprising an arrangement of electrically conductive filaments arranged to define an air impingement surface, the air impingement surface being concave in a direction of an airflow that arrives at the concave air impingement surface, the electrically conductive filaments forming a mesh, the mesh not including a dedicated filament opening,
wherein the capillary medium is provided in contact with the heater assembly, the capillary medium is configured to draw the liquid aerosol forming substrate to the electrically conductive filament arrangement, and the capillary medium comprises a capillary medium opening which does not extend through the fluid permeable heater assembly.

US Pat. No. 10,426,194

FLAVOR INHALER AND INSIDE HOLDING MEMBER

JAPAN TOBACCO INC., Toky...

1. A flavor inhaler comprising:a cylindrical holding member extending from an ignition end to a non-ignition end;
a combustion heat source provided at the ignition end;
a flavor source provided on the non-ignition end side with respect to the combustion heat source;
an inside holding member that is provided into the cylindrical holding member, and retains at least the flavor source; and
an introduction port that introduces air to the flavor source, wherein
the inside holding member has a first side wall having a cylindrical shape to surround at least a part of the flavor source;
the cylindrical holding member has a second side wall having a cylindrical shape to surround the first side wall;
the introduction port is formed on the first side wall;
the second side wall has a through-hole that is fluidly coupled to external air;
the flavor inhaler further comprises a first flow path and a second flow path, the first flow path connecting the through-hole and the introduction port each other and passing between the first side wall and the second side wall, the second flow path connecting the flavor source and a suction port provided at the non-ignition end of the cylindrical holding member to suck flavor generated at the flavor source; and
a flow-path forming member is formed such that a length of a flavor source outer perimeter segment that is a section corresponding an outer perimeter of the flavor source, in the first flow path, is longer than a shortest length connecting the introduction port and a location where the external air from the through-hole flows into the flavor source outer perimeter segment.

US Pat. No. 10,426,190

MOIST TOBACCO PRODUCT AND METHOD OF MAKING

Philip Morris USA Inc., ...

1. A moist tobacco product for oral enjoyment having a membrane coating, the moist tobacco product comprising:a molded portion of moist tobacco material;
a multi-component polymer coating on said portion of moist tobacco material; and
said coating comprising a membrane coating on the molded moist tobacco material wherein said membrane coating comprises an insoluble component and a soluble component, the insoluble component forming a porous network due to dissolution of the soluble component when the moist tobacco product is placed in an oral cavity.

US Pat. No. 10,426,189

METHOD OF MANUFACTURING CUT STEM, CUT STEM MANUFACTURING APPARATUS, AND CUT STEM

JAPAN TOBACCO INC., Toky...

1. A cut stem manufacturing method comprising:tearing a rod-like stem material having a water content of 20 to 50% by weight;
shredding the torn rod-like stem material; and
subjecting the rod-like cut stem material to expansion treatment,
wherein the rod-like stem material is torn by passing the rod-like stem material between two rollers rotating in opposite directions at different speeds.

US Pat. No. 10,426,178

DECAFFEINATION METHODS AND SYSTEMS

1. A water based method for producing decaffeinated tea leaves comprising:(i) adding water having a temperature of less than 70° C. (degrees Celsius) to tea leaves to form an aqueous tea leaf mixture;
(ii) separating the tea leaves from the aqueous tea leaf mixture to obtain an aqueous extract and extracted tea leaves;
(iii) contacting the aqueous extract of (ii) with an active carbon adsorbent (ACA);
(iv) adsorbing caffeine in the extract reversibly to the ACA to obtain an aqueous decaffeinated tea extract (DTE);
(v) contacting the aqueous DTE of (iv) with the extracted tea leaves of (ii) to form a further aqueous tea leaf mixture, repeating (ii) to (v) until at least 85% of the caffeine is removed from the tea leaves, wherein
(i) to (v) are water-based, and
the repeating of (ii) to (v) causes an increase in concentration, up to the equilibrium concentration, of non-caffeine water soluble tea components in the aqueous DTE, which causes a reduction of the extraction of non-caffeine water soluble tea components from the tea leaf into the aqueous DTE in the repeated steps, and
(vi) drying the further aqueous tea leaf mixture to obtain the decaffeinated tea leaves, wherein the decaffeinated tea leaves retain at least about 50% of the non-caffeine water soluble components of the tea leaves provided in (i).

US Pat. No. 10,426,174

AUTOMATIC BREAD MAKER, INGREDIENT BOX AND BREAD MAKING METHOD

TSANN KUEN (ZHANGZHOU) EN...

1. A bread making method, comprising:providing an automatic bread maker including a housing; a hanging rack provided with a saw tooth blade; and a lid;
providing a bread ingredient box having a first accommodating room; and having an outer wall that is weak;
putting bread ingredients including flour and baking powder according to a proper bread formula into the first accommodating room of the bread ingredient box and packaging the bread ingredients within the bread ingredient box;
placing the outer wall of the bread ingredient box face down on the hanging rack above a baking pan inside the automatic bread maker, causing the sawtooth blade of the hanging rack to pierce the outer wall of the bread ingredient box and allowing the bread ingredients to drop into a stock bin for temporary storage, controlling covers of the stock bin to open as required, causing at least some of the bread ingredients to drop into the baking pan and adding water to the bread ingredients within the baking pan at the same time;
processing the bread ingredients and the water into a working dough by mixing, stirring and kneading, to provide a first dough within the baking pan;
resting and fermenting the first dough within the baking pan, and causing fermentation air to degas out of the first dough;
heating and baking the dough in the baking pan until the bread is baked; taking the baking pan out of the automatic bread maker, and removing the bread.

US Pat. No. 10,426,173

AUTOMATIC BREAD MAKER AND INGREDIENT BOX FOR THE SAME

TSANN KUEN (ZHANGZHOU) EN...

1. An automatic bread maker, comprising:a housing;
a baking pan disposed inside the housing to mix and heat bread ingredients and disposed with an entrance that is upwardly facing; and
a hanging rack disposed inside the housing that accommodates a bread ingredient box and a stock bin disposed above the hanging rack and above the entrance of the baking pan;
wherein the hanging rack is disposed with a sawtooth blade that faces upwardly to pierce the bread ingredient box and the stock bin is disposed with a drop opening that faces the entrance and that has a size that is smaller than that of the entrance so that, when the ingredient box is pierced, the bread ingredients of the bread ingredient box drop down into the stock bin,
wherein the stock bin includes a tubular wall and a cover coupled to the drop opening of the stock bin at a bottom portion of the tubular wall, and
wherein a driver is further disposed to control opening and closing of the cover of the stock bin relative to the tubular wall to discharge at least a portion of the bread ingredients contained inside the stock bin through the drop opening when the driver opens the cover or to retain the bread ingredients contained inside the stock bin when the driver closes the cover.

US Pat. No. 10,426,169

HETEROARYLPIPERIDINE AND -PIPERAZINE DERIVATIVES AS FUNGICIDES

BAYER INTELLECTUAL PROPER...

1. A compound of formula (XXVII)
or a salt, metal complex or N-oxide thereof,
in which the radicals are each defined as follows:
RB1 is hydrogen, cyano, hydroxyl, C1-C3-alkyl, C2-C3-alkenyl, C2-C3-alkynyl, C1-C3-haloalkyl, C2-C3-haloalkenyl, C2-C3-haloalkynyl, C2-C3-alkylcarbonyl, C2-C3-haloalkylcarbonyl, C1-C3-alkoxy, C1-C3-haloalkoxy, C1-C3-alkylthio, C1-C3-haloalkylthio, C1-C2-alkylcarbonyloxy, or C1-C2-haloalkylcarbonyloxy,
RB2 is hydrogen,
X is carbon,
R2 is hydrogen,
p is 0,
G is

where the bond identified by “v” is bonded directly to X and where the bond identified by “w” is bonded directly to Q,
RG1 is hydrogen,
Q is

where the bond identified by “x” is bonded directly to G, and where the bond identified by “y” is bonded directly to L2,
R5 is hydrogen,
L2 is a direct bond,
R1 is phenyl which is substituted at least once by a Z4 substituent and may otherwise be unsubstituted or substituted, where the substituents are each independently selected from Z4 and optionally from Z1-2,
Z1-2 is hydrogen, halogen, cyano, hydroxyl, amino, nitro, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C3-C8-cycloalkenyl, C3-C8-halocycloalkenyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylcarbonyl, C3-C8-cycloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkoxy, C3-C8-halocycloalkoxy, C1-C6-alkylcarbonyloxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, C3-C8-cycloalkylsulfonyl, tri(C1-C4-alkyl)silyl, or -L3Z3,
L3 is a direct bond, —CH2—, sulfur, oxygen or —(S?O)2—,
Z3 is a phenyl radical, naphthalenyl or a 5- or 6-membered heteroaryl radical which may contain up to two substituents, where the substituents are each independently selected from the following list:
halogen, cyano, nitro, hydroxyl, amino, —SH, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C2-C4-haloalkenyl, C2-C4-haloalkynyl, C2-C4-alkoxyalkyl, C1-C6-alkylcarbonyl, C1-C6-haloalkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C2-C6-alkenyloxy, C2-C6-alkynyloxy, C1-C4-alkylthio, C1-C4-haloalkylthio, C1-C4-alkylsulfonyl, C1-C4-haloalkylsulfonyl or C1-C4-alkylamino, di(C1-C4-alkyl)amino,
substituents on nitrogen: hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C 1-C 6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C1-C4-alkoxy-C1-C4-alkyl, phenyl, benzyl, C 1-C4-haloalkylsulfonyl, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, phenylsulfonyl, C1-C4-alkylsulfonyl, —C(?O)H, or C1-C3-alkylcarbonyl, and Z4 is C1-C6-alkylsulfonyloxy.

US Pat. No. 10,426,168

AGENT FOR CONTROLLING NOXIOUS ARTHROPODS

SUMITOMO CHEMICAL COMPANY...

1. An agent for controlling harmful arthropods, the agent comprising an inert carrier and an amide compound represented by formula (I):wherein:R2 represents a C1-C3 chain hydrocarbon group optionally substituted with one or more substituents selected from a group consisting of hydroxy group and halogen atom, a hydrogen atom, a halogen atom, a cyano group and a formyl group,
R9 represents a C1-C4 alkyl group optionally substituted with one or more fluorine atoms or a C1-C4 alkoxy group optionally substituted with one or more fluorine atoms,
R10 represents a C1-C4 alkyl group optionally substituted with one or more fluorine atoms, a C1-C4 alkoxy group optionally substituted with one or more fluorine atoms, or a hydrogen atom,
R11 represents a C1-C4 alkyl group optionally substituted with one or more fluorine atoms, a C1-C4 alkoxy group optionally substituted with one or more fluorine atoms, or a hydrogen atom,
R12 represents a C1-C4 alkyl group optionally substituted with one or more fluorine atoms, a C1-C4 alkoxy group optionally substituted with one or more fluorine atoms, or a hydrogen atom,
Y represents a single bond,
m is 0, and Q represents a 1-propyl, 1-butyl, 1-pentyl, 1-hexyl, 1-heptyl, or 1-octyl group,
each of a and b is 0, 1, 2, or 3, provided that the sum of a and b represents any one of an integer of 1 to 6.

US Pat. No. 10,426,167

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

1. A synergistic fungicidal mixture comprising at least one fungicidal multi-site inhibitor selected from the group consisting of captan, chlorothalonil, copper bis(3-phenylsalicylate), copper hydroxide, copper octanoate, copper oxychloride, copper sulfate, copper sulfate (tribasic), copper zinc chromate, cupric hydrazinium sulfate, cuprobam, cuprous oxide, folpet, mancozeb, maneb, metiram, propineb, mancopper and oxine-copper and a fungicidally effective amount of a compound of Formula I:

US Pat. No. 10,426,166

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

6. A synergistic fungicidal composition comprising an agriculturally acceptable adjuvant or carrier and a fungicidally effective amount of the synergistic fungicidal mixture of claim 1.

US Pat. No. 10,426,165

SYNERGISTIC FUNGICIDAL MIXTURES AND COMPOSITIONS COMPRISING 5-FLUORO-4-IMINO-3-METHYL-1-TOSYL-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE FOR FUNGAL CONTROL

ADAMA MAKHTESHIM LTD., B...

15. A synergistic fungicidal composition comprising an agriculturally acceptable adjuvant or carrier and a fungicidally effective amount of the synergistic fungicidal mixture of claim 1.

US Pat. No. 10,426,155

SMALL CHEWING MAMMAL DETERRENT APPARATUS AND METHOD

17. A method is provided for deterring small chewing mammals, comprising:providing an array of green light emitting diodes (LEDs), a power supply, and control circuitry including temperature sensor circuitry and timing circuitry;
distributing the array of green light emitting diodes (LEDs) in an environment having equipment at risk of chewing damage from small chewing mammals;
enabling with the temperature sensor circuitry the operation of the timing circuitry when the ambient temperature is below a threshold temperature determined based on the small chewing mammals; and
enabling with the timing circuitry the operation of the array of green light diodes to illuminate at short intervals with a pulse duration of 10 to 50 milliseconds and a pulse frequency of 0.2 to 5 Hertz to provide a constant photoreceptor effect from 0.00173 to 0.0518 seconds and generate a response in the ocular rod cells of small chewing mammals that annoys small chewing mammals.

US Pat. No. 10,426,153

ROD HOLDER ASSEMBLY

1. A rod holder assembly comprising:a receiving member comprising a cylindrically shaped rod receiver for supporting a fishing rod; a gear assembly engaged to the rod receiver and governing rotational movement of the rod receiver about a horizontal axis comprising a first housing element and a second housing element, wherein the first housing element comprises a first protrusion array affixed to a lateral face of the first housing element and wherein the second housing element comprises a first depression array affixed to a lateral face of the second housing element; and a base assembly governing rotational movement of the rod receiver about a vertical axis comprising a platform engaged to and supporting at least one of said housing elements of the gear assembly; and
a mounting mechanism comprising a cylindrically shaped main housing for supporting and substantially concealing the receiving member, wherein said main housing comprises an open upper end a lower end, and a tubular shaped inner surface for guiding the receiving member's travel through main housing between an exposed position wherein the cylindrically shaped rod receiver is adjustable about the horizontal axis to a substantially concealed position wherein cylindrically shaped rod receiver is not adjustable about the horizontal axis; and
wherein the rod receiver is locked into the substantially concealed position by a retention element.

US Pat. No. 10,426,151

DRAG ADJUSTMENT ASSEMBLY FOR A STAR DRAG REEL

Pure Fishing, Inc., Spir...

1. A drag adjustment assembly comprising:a lever arm unit forming a housing and comprising at least one keyway;
a nut having a threaded inner surface positioned partially in the housing;
a first keyed structure positioned in the housing, wherein the first keyed structure comprises at least one key engaging the at least one keyway and a threaded surface engaging the threaded inner surface of the nut;
a second keyed structure positioned in the housing, wherein the second keyed structure comprises at least one key engaging the at least one keyway; and
a spring secured between the first and second keyed structures.

US Pat. No. 10,426,150

TUBULAR STRUCTURE HAVING DECORATIVE LAYER AND METHOD OF FORMING DECORATIVE LAYER ON TUBULAR STRUCTURE

Globeride, Inc., Tokyo (...

1. A tubular structure comprising:a tubular body extending in an axial direction, the axial direction being defined by a center axis extending through a center of the tubular body; and
a decorative layer formed on a surface of the tubular body in a prescribed portion, the decorative layer having a lattice-like pattern in which first regions of a first color and second regions of a second color different from the first color are alternately arranged in the axial direction and a circumferential direction of the tubular body, wherein
the decorative layer includes axial-direction decorative rows arranged in the circumferential direction of the tubular body, each of the axial-direction decorative rows includes the first regions having a first prescribed shape and the second regions having a second prescribed shape that are alternately arranged along the axial direction of the tubular body, and
the second regions in each of the axial-direction decorative rows are formed such that one of the first regions in one axial-direction decorative row of the axial-direction decorative rows has a portion that is partially situated between two axially-adjacent first regions of the first regions in a next axial-direction decorative row of the axial-direction decorative rows adjacent to the one axial-direction decorative row in the circumferential direction with a clearance between the one first region in said one axial-direction decorative row and the two axially-adjacent first regions in said next axial-direction decorative row,
wherein the portion is defined as being between (a) a first axial line extending in the axial direction that only intersects edges of the first prescribed shapes of the first regions in the next axial-direction decorative row and intersects the first prescribed shapes of the first regions in the one axial-direction decorative row and (b) a second axial line extending in the axial direction that only intersects edges of the first prescribed shapes of the first regions in the one axial-direction decorative row and intersects the first prescribed shapes of the first regions in the next axial-direction decorative row, both the first axial line and the second axial line being parallel to the center axis.

US Pat. No. 10,426,149

METHODS AND APPARATUS FOR ENHANCED AUDIBLE FISHING EQUIPMENT WITH HEAT SHRINK

1. An audibly enhanced fishing lure comprising:a lure spoon comprising a convex side, a concave side, a hole through the convex side to the concave surface side at a proximate end of the lure spoon, a hole through the convex side to the concave side at a mid-portion of the lure spoon, and a hole through the convex side to the concave side at a distal end of the lure spoon;
a hook comprising a shank, a point and a fastening area, said fastening area fixedly attached to the hole at the mid-portion of the lure spoon with a fastener;
an audible generator fixedly attached to the shank of the hook via a first heat shrink tube;
a swivel with a proximate end and a distal end, said proximate end of the swivel attached to the hole at the distal end of the lure spoon; and
a second shrink tube fixedly attaching the shank of the hook to the swivel at a portion of the hook positioned beyond the distal end of the lure spoon, thereby fixedly positioning the hook to extend from the hole at the mid-portion of the spoon to beyond the distal end of the spoon.

US Pat. No. 10,426,148

CRAB POT

1. A crab pot, comprising:a top, a bottom, and at least one side wall disposed between the top and the bottom, the top, bottom, and the at least one side wall being supported by a frame and enclosing an interior space;
at least one entrance tunnel in the at least one side wall to permit entry of an animal into the interior space, the at least one entrance tunnel being made of injection molded plastic and including a first end adjacent the at least one side wall, a second end opposite the first end, and a trigger mount monolithically formed in a flat section of the at least one entrance tunnel, where the second end is disposed within the interior space and the trigger mount defines a depression in the flat section of the at least one entrance tunnel;
a trigger comprising at least one rod attached to a pivotable portion, the trigger pivotably mounted via the pivotable portion recessed in the depression in the flat section and on an upper portion of the at least one entrance tunnel at the second end of the at least one entrance tunnel, wherein the trigger pivots away from the first end of the at least one entrance tunnel into the interior space and wherein the depression receives the pivotable portion of the trigger such that the pivotable portion is recessed within the flat section of the at least one entrance tunnel; and
a trigger cover detachably attached to the at least one entrance tunnel to cover the depression such that the pivotable portion of the trigger is covered.

US Pat. No. 10,426,145

WAVE-MAKING PUMP WITH NOVEL DIRECTIONAL STRUCTURE

1. A wave-making pump, comprising a casing, a motor, an impeller that produces a wave, and a fixing device, wherein the motor is fixed in the casing; the impeller is arranged at an output end of the motor; the fixing device is used for fixing the casing; the wave-making pump is characterized in that the casing comprises a rear casing and a diversion protective cover arranged on a front side of the rear casing; openings are formed at two ends of the diversion protective cover; a hollow groove helically extending is formed in peripheral surface of the diversion protective cover; a diversion bar forming an 8 shape along an axis of the diversion protective cover is arranged at one of the openings far from the motor, of the diversion protective cover; the fixing device comprises an outer magnetic sucker, an inner magnetic sucker and a ferromagnetic body arranged in the rear casino, wherein both the outer magnetic sucker and the inner magnetic sucker are provided with a magnet; the outer magnetic sucker and the inner magnetic sucker attract each other to clamp a wall of an aquarium; the ferromagnetic body and the inner magnetic sucker attract each other, so as to ensure that the rear casing is connected with the wall of the aquarium.

US Pat. No. 10,426,144

TERRARIUM AND RELATED METHOD OF USE

1. A terrarium comprising:a base including a first base channel and a second base channel;
a support column including an upper end and a lower end, the column extending upwardly from the base, the lower end secured to the base;
a top including a first top channel and a second top channel, the top being supported entirely by the support column at a first preselected distance from the base;
a first arcuate panel extending between the top and the base, the first arcuate panel being disposed in the first top channel and the first base channel, the first arcuate panel forming an opening between the top and the base;
a second arcuate panel extending between the top and the base, the second arcuate panel being disposed in the second top channel and the second base channel, the second arcuate panel forming a closure of the opening,
wherein at least one of the first and second arcuate panels is a transparent panel,
wherein the first and second arcuate panels cooperate with the top and the base to define an internal compartment,
wherein the support column extends within the internal compartment,
wherein the closure is selectively slidable within the second top channel and the second base channel to provide access to the internal compartment between the top and the base.

US Pat. No. 10,426,143

SYSTEMS AND METHODS FOR LARVAL FISH ENUMERATION AND GROWTH MONITORING

FLORIDA ATLANTIC UNIVERSI...

1. A method for object enumeration in a culture tank, comprising:obtaining an array of two dimensional images of an illuminated scene in the culture tank;
correcting non-uniform background illumination in the two dimensional images;
improving a color contrast between a background and object edges shown in the two dimensional images;
performing a defocus analysis using the two dimensional images to generate a focus map image;
generating a modified focus map image by eliminating isolated spots shown in the focus map image and merging small spots with adjacent large objects in the focus map image;
classifying each object shown in the modified focus map image as an object of interest or an object of no interest, wherein the object of interest comprises larvae and the object of no interest comprises bubbles and feed; and
counting a number of objects classified as objects of interest.

US Pat. No. 10,426,139

PET GROOMING ENCLOSURE

1. An accessory for grooming an animal comprising:an enclosure that is adapted to receive an animal;
wherein said enclosure includes a plurality of suction nozzles that are adapted to collect water and debris from said animal;
wherein the enclosure is further defined with a top portion and a bottom portion;
wherein the top portion is affixed to and is seated onto the bottom portion along a perimeter edge;
wherein the enclosure includes a first opening and a second opening;
wherein the first opening includes a door that is attached to both the top portion and the bottom portion;
wherein the door pivots with respect to the enclosure via a top hinge and a bottom hinge;
wherein the top hinge connects to both the door and the top portion;
wherein the bottom hinge connects to both the door and the bottom portion;
wherein the first opening is provided on a front surface of the enclosure;
wherein the door provides access to an interior of the enclosure;
wherein the second opening is provided on a rear surface of the enclosure;
wherein the rear surface is distal of the front surface;
wherein the rear surface and the front surface are separated from one another via an enclosure length;
wherein the enclosure is adapted to receive said animal within the interior;
wherein the enclosure includes the plurality of vacuum nozzles within the interior of the enclosure;
wherein the plurality of vacuum nozzles are strategically located throughout the interior of the enclosure in order to adaptively remove water and debris from said animal.

US Pat. No. 10,426,137

ANIMAL TROUGH

1. An animal trough comprising:an inner wall with an inner surface and an elliptic, arcuate outer surface;
an outer wall with an inner surface and outer surface;
a compartment configured to removably receive a first fluid and formed between the inner surface of the inner wall and the inner surface of the outer wall;
a receptacle with an inverted, elliptic dome-shape that is configured to receive a second fluid and that is defined by the elliptic, arcuate outer surface of the inner wall, such that the receptacle is smooth and the inner wall separates the compartment from the receptacle such that the first fluid is separated from the second fluid; and
an insert including an insert outer surface shaped to substantially conform to the elliptic, arcuate outer surface of the inner wall when the insert is removably nested within the receptacle, the insert being configured to remove debris from the receptacle when removed from the receptacle.

US Pat. No. 10,426,135

METHYL- AND TRIFLUROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

Pfizer Inc., New York, N...

1. A method of treating a condition in a patient, wherein the condition is selected from the group consisting of plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, and erythrodermic psoriasis, comprising administering to the patient in need of such treatment a therapeutically effective amount of a compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein,Y is —CF3;
X is phenyl optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of —CH3, —CH2CH3, —CH2OH, —OH, —OCH3, —SCH3, —OCH2CH3, —OCH2CH2OH, —OCH2CH2OCH3, —F, —Cl, —Br and —CN;
R1 is —CH3 or —CH2CH3;
W is
each optionally substituted with one, two, three, four or five —CH3; andR2 is (C1-C6)alkyl, (C3-C10)cycloalkyl, phenyl, tetrahydrothiophenyl, thietanyl or indanyl, optionally substituted with one, two, three, four or five substituents independently selected for each occurrence from the group consisting of —F, —Cl, —Br, —OH, (C1-C3)alkyl, (C1-C3)haloalkyl and (C3-C10)cycloalkyl.

US Pat. No. 10,426,132

SMALL ANIMAL RESISTANCE EXERCISE SYSTEM

Kuwait University, Safat...

1. A small animal resistance exercise system, comprising:a main track compartment having a floor portion and opposing side walls positioned on the floor portion, the floor portion including a plurality of open-ended grooves and a plurality of closed-ended grooves defined therein, and each of the opposing side walls including an upright portion, a roof portion extending from a top end of the upright portion, and a base portion extending from a bottom end of the upright portion;
a pair of trap compartments, each of the trap compartments including a floor portion and opposing side walls positioned on the floor portion, the floor portion including a plurality of open-ended grooves and a plurality of closed-ended grooves defined therein, each of the sidewalls including an upright portion, a roof portion extending partially along a top end of the upright portion, and a base portion extending from a bottom end of the upright portion;
a plurality of screws configured for extending through the base portion of the trap compartments and the main track compartment and engaging the closed-ended grooves of the floor portion;
a pulley system including:
a clamp and a pulley shaft, the pulley shaft having an upper end and a lower end, the lower end being pivotally attached to the clamp;
a first pulley wheel rotatably attached to the upper end of the pulley shaft;
a second pulley wheel pivotally attached to the clamp;
a rope trained on the pulley wheels; and
one or more weight plates for attaching to an end of the rope.

US Pat. No. 10,426,130

COLLAPSIBLE PET CARRIER

1. A collapsible pet carrier comprising:an interior space defined between opposing side walls, opposing end walls, and a bottom wall;
one or more straps attached to one of the opposing side walls and opposing end walls;
a cover movably attached over a top opening of the collapsible carrier;
a pair of opposing pockets located on an exterior portion of the bottom wall, the pair of opposing pockets separated by a slit;
a board shaped to fit at least partially within the pair of opposing pockets and across the slit;
a closure mechanism formed along an edge of the exterior portion of the bottom wall;
wherein in an expanded configuration the board is located at least partially within both of the pair of opposing pockets of the bottom wall; and
wherein in a collapsed configuration the board does not extend across the slit such that opposing side walls, opposing end walls, straps, and cover are folded towards the bottom wall and the bottom wall is folded along a center of the bottom wall and secured closed with the closure mechanism.

US Pat. No. 10,426,129

CHEESE-MAKING METHODS AND APPARATUSES

1. A method for making pasta filata cheese comprising:flowing a dairy product through a product tube, wherein the dairy product comprises cheese curds;
heating the dairy product within a cooking portion of the product tube within a cooking chamber by applying electromagnetic energy to said dairy product within said cooking portion of the product tube from an electromagnetic energy source through an energy suppression tube which suppresses the electromagnetic energy from the electromagnetic energy source, wherein the energy suppression tube surrounds the cooking portion of the product tube, and the cooking chamber surrounds a portion of the energy suppression tube such that said electromagnetic energy passes through said portion of the energy suppression tube to reach the dairy product within said cooking portion of the product tube; and
collecting a heated dairy product from the product tube.

US Pat. No. 10,426,127

CAMERA SYSTEM, ANIMAL RELATED SYSTEM THEREWITH, AND METHOD TO CREATE 3D CAMERA IMAGES

LELY PATENT N.V., Maassl...

1. A camera system configured to create 3D images of an object, comprising:a 3D camera device to capture images of the object;
wherein the 3D camera device comprises at least two components, a first component comprising a first 2D receiver arranged to capture images of the object, and a second component comprising
an illuminating unit configured to project light on the object;
a processing device operatively connected to the 3D camera device and arranged to determine a 3D image from the captured images; and
a mover device configured to move at least one of the components with a reciprocating movement during capturing of images, wherein the mover device comprises an inactive state in which the mover device does not move at least one of the at least two components with a reciprocating movement, and an active state in which the mover device moves at least one of the at least two components with a reciprocating movement, wherein the camera system is configured to determine whether the object cannot be properly identified with the camera system when the mover is in the inactive state, and wherein the camera system is configured to bring the mover device from the inactive state to the active state when a position of the object cannot be properly identified with the camera system when the mover device is in the inactive state.

US Pat. No. 10,426,117

LETTUCE VARIETY 79-135 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A seed of lettuce variety 79-135 RZ, a sample of seed of said variety having been deposited under NCIMB Accession No. 42678.

US Pat. No. 10,426,108

ASSEMBLY WELL IRRIGATION SYSTEM FOR ENVIRONMENTALLY FRIENDLY WATER CONSERVATION

1. An assembly well irrigation system for environmentally friendly water conservation, comprising:at least one well, having a ventilation tube inserted into the top of the well, an absorbent element covered onto the bottom and outer wall of the ventilation tube and filled up in an opening formed between the top of the well and the ventilation tube, and a float contained in the ventilation tube; and
at least one water supply bottle, having a cover installed to the opening of the water supply bottle, and the cover having a fixed tube passing through the cover and a penetrating hole formed on the cover, and the penetrating hole having a movable tube capable of moving up and down for an adjustment, and the water supply bottle being inverted, such that the cover is installed to the well, and the fixed tube, the movable tube and the ventilation tube are situated in the well.

US Pat. No. 10,426,104

PRESSURE COMPENSATING EMITTER HAVING VERY LOW ACTIVATION PRESSURE AND LARGE OPERATING RANGE

Massachusetts Institute o...

1. Pressure-compensating emitter comprising:an inlet connected to a source of pressurized water;
an orifice in fluid communication with the inlet and extending into a channel including a raised land surrounding an outlet; and
a compliant membrane positioned above the land in the chamber wherein the pressurized water will cause the membrane to deform into contact with the land to alter flow through the outlet;
wherein dimensions of the orifice, land diameter, channel dimensions, outlet diameter and membrane characteristics are selected to provide substantially constant flow for varying water pressure with an activation pressure of 0.15 bar or below wherein the compliant membrane sits above the raised land by approximately 0.7 mm.

US Pat. No. 10,426,103

MULTILEVEL CLOSED ECOSYSTEM GREENHOUSE

1. A greenhouse comprising:a light-transmitting barrier; and
a floor surface;
the barrier and the floor surface defining an enclosure within the greenhouse for plant cultivation, the barrier comprising an inner layer delimiting the enclosure and an outer layer, the inner and outer layers being impermeable to air to prevent air from entering the enclosure through the inner layer, a shape of the outer layer being the same as a shape of the inner layer, the outer layer being spaced apart above the inner layer to define an air passage therebetween, the air passage being in fluid communication with at least one air inlet in a bottom portion of the outer layer and with an air outlet, the air passage being unobstructed between the at least one air inlet and the air outlet to allow air within the air passage to flow passively from the at least one air inlet to the air outlet upon being heated; and
an outlet tower mounted to a top portion of the outer layer and extending upwardly from an opening in an apex of the barrier to an outlet passage, the outlet tower having an hourglass shape and curved airfoil surface, and an inlet guide vane spaced inwardly from the curved airfoil surface to define a gap therebetween, the gap being in fluid communication with a secondary air inlet to provide air into the gap.

US Pat. No. 10,426,101

PLANT POT WITH IRREGULAR BOTTOM EDGE

1. An expandable planter pot for insertion into the ground, the pot comprising:a plurality of adjacent arcuate sections forming the expandable planter pot, a size of the expandable planter pot increasing or decreasing based on a number of adjacent arcuate sections included in the plurality of adjacent arcuate sections forming the expandable planter pot;
wherein each of the plurality of adjacent arcuate sections has a pair of upper connection tabs and a pair of lower connection tabs;
wherein each of the plurality of adjacent arcuate sections is joined to another adjacent arcuate section by aligning openings of the pair of upper connection tabs and openings of the pair of lower connection tabs of each arcuate section, using zip tie closures through the respective openings, thereby forming a continuous, unbroken sidewall of said planter pot, said sidewall comprising an upper rim and a lower peripheral edge that defines an open bottom, said lower peripheral edge comprising a formation of serrated teeth suitable for gouging the ground, wherein the pot is rigid for inserting into the ground by rotating the pot to gouge the ground;
wherein each of the pair of upper connection tabs:
is defined by the upper rim of each of the plurality of adjacent arcuate sections,
is integrated with the upper rim, and
forms a wall at both ends of the upper rim;
wherein each of the pair of upper connection tabs extends horizontally outward from an interior of the pot;
wherein each of the pair of lower connection tabs extends horizontally inward along a vertical cross-section of each of the plurality of adjacent arcuate sections; and
wherein said lower peripheral edge defines the open bottom so that the expandable planter pot is bottomless.

US Pat. No. 10,426,100

DRAINAGE COLLECTION CONTAINER

Plantlogic LLC, Smyrna, ...

1. A container for a plant, the container comprising:a body having an open top, a base, a sidewall extending upward from the base, holes extending through the base, legs extending downward from the base, and a vertical axis extending from the open top and through the base, wherein the holes comprise a first set of holes each having an opening facing the open top and at a lowest vertical elevation with respect to the vertical axis, the first set of holes comprises downward extending walls from a bottom surface of the base that are configured to induce liquid drainage from the container through the first set of holes, and the holes comprise a second set of holes each having an opening facing the open top and at an upper vertical elevation relative to the first set of holes and with respect to the vertical axis, wherein each of the openings of the first set of holes and each of the openings of the second set of holes form a plane that is perpendicular to the vertical axis, and the second set of holes comprises upward extending walls from a top surface of the base that are configured to substantially only permit air uptake to roots of a plant in the container and configured to not facilitate liquid drainage from the container through the second set of holes; and
a gutter configured to collect drainage from the first set of holes in the container, wherein the gutter has a width that fits between the legs of the container, and the gutter has a length that is greater than that of the container.

US Pat. No. 10,426,099

METHOD FOR CONTROLLING A GROWTH CYCLE FOR GROWING PLANTS USING STATE ORIENTED CONTROL

1. A computer implemented method for controlling of a growth cycle for a plant of a predetermined type comprising chlorophyll arranged in a controlled environment, to enable said plant to reach a desired growth status, said method comprising the steps of:defining a set of growth states, each of said growth states being a state of said growth cycle, wherein a selection of property values of respective detectable properties of said plant is within a defined range, and each of said growth states being associated with a plurality of growth regimes defining control of an artificial lighting arrangement for adjusting light spectral composition and/or light intensity; and
when in a present growth state:
determining, by means of a plurality of sensors, a current growth status of said plant, wherein said current growth status comprises a set of said property values of respective detectable properties of said plant, and
selecting a growth regime of said plurality of growth regimes and controlling said artificial lighting arrangement according to said selected growth regime,
wherein the step of selecting a growth regime in said present growth state is based on said desired growth status, said determined current growth status, and on previously selected growth regimes in previous growth states.

US Pat. No. 10,426,098

REMOTE-CONTROLLED ROBOTIC EQUIPMENT FOR TREE PRUNING NEAR ENERGIZED POWER LINES

1. A remote-controlled robotic equipment for tree pruning near energized power lines, said robotic equipment comprising:a stand and a truck trailer, wherein the stand is arranged along the rear of the truck trailer:
a base arranged over the truck trailer, including hydraulic jaws arranged on the lateral ends of the base, hydraulic actuators to stabilize and anchor the truck trailer arranged adjacent to the hydraulic jaws, and a gearing tower arranged over the base, said base comprising a rectilinear positioning rod arranged on the gearing tower and two telescopic booms each with three rotating shafts driven by hydraulic motors and two prismatic joints driven by hydraulic pistons and one hydraulic feeding system;
a rectilinear drive rod arranged on the rectilinear positioning rod and comprising a telescopic boom with three rotating joints driven by hydraulic motors and one prismatic joint driven by hydraulic pistons, a block-shaped end effector arranged on the rectilinear drive rod and containing a coupling arranged on the end effector, and a saw or a pole pruner or a pressure claw arranged on the coupling;
a collection bin arranged over the truck trailer;
a shredder arranged over the truck trailer;
a set of optical fibers for communication between components of said remote-controlled robotic equipment;
encoders to identify the actual position of the rectilinear positioning rod and the rectilinear drive rod; and
a remote control to control the remote-controlled robotic equipment by a man-machine interface.

US Pat. No. 10,426,097

AGRICULTURAL BALER WITH STARTUP MODE

1. An agricultural harvesting machine for crop material comprising:a crank arm connected to a rotational power source;
a plunger having an extended position which is located further rearward in a compression chamber than a retracted position; and
a connecting link connected between the plunger and the crank arm, one of the connecting link and the crank arm having a variable length, the movement of the plunger being decoupled from the movement of the crank arm during a startup mode, in which the crank arm is rotating below an operational speed, and the movement of the plunger being coupled to the movement of the crank arm during a run mode, in which a speed of the crank arm is rotating below an operational speed.

US Pat. No. 10,426,096

PLUNGER AND PRE-COMPRESSION CHAMBER LINK

CNH Industrial America LL...

1. An agricultural baler comprising:a baling chamber;
a plunger configured for reciprocally moving in the baling chamber;
a first drive that is drivingly linked to the plunger;
a pre-compression chamber comprising a stuffer oriented for pushing a slice of crop material into the baling chamber;
a second drive in driving connection with the stuffer, the first drive and the second drive being linked by a mechanical link to ensure synchronization;
a first rotating shaft connected to the first drive;
a second rotating shaft connected to the second drive; and
a gearbox comprising an intermediary element linking the first and second rotating shafts, the gearbox mounted in the mechanical link wherein the gearbox is provided to adjust a synchronization timing between a position of the plunger and a position of the stuffer, the intermediary element movable between a first position and a second position, the first and second rotating shafts having a relative angular position with respect to each other,
wherein the relative angular position of the first and second shafts when the intermediary element is in the first position is different from the relative angular position of the first and second rotating shafts when the intermediary element is in the second position.

US Pat. No. 10,426,095

AGRICULTURAL BALER WITH PLUNGER REPOSITION DURING STARTUP MODE

1. An agricultural harvesting machine for crop material comprising:a crank arm connected to a rotational power source;
a plunger having an extended position which is located further rearward in a compression chamber than a retracted position; and
a connecting link connected between the plunger and the crank arm, one of the connecting link and the crank arm having a variable length;
a startup mode in which the rotational power source accelerates up to an operational speed, the movement of the plunger being decoupled from the movement of the crank arm at the beginning of the startup mode, the plunger moving to a retracted position after the rotational power source has attained an intermediate speed which is less than the operational speed, and the plunger remains in the retracted position until the rotational power source has attained the operational speed; and
a run mode in which the rotational power source has attained the operational speed, and the movement of the plunger being coupled to the movement of the crank arm during the run mode.

US Pat. No. 10,426,094

HARVESTER RECIPROCATING DRIVE BALANCING SYSTEM

1. A harvester reciprocating drive balancing system comprising:a crop material separating member movably supported for reciprocal movement;
a drive operably coupled to the crop material separating member to reciprocate the crop material separating member, the drive comprising:
a drive crank operably coupled to the crop material separating member;
a shaft operably coupled to the drive crank;
a belt drive;
a driven pulley;
a belt wrapped about the belt drive and the driven pulley; and
a gear reduction mechanism operably coupled between the driven pulley and the shaft.

US Pat. No. 10,426,093

CONICAL ROTOR DISCHARGE HOUSING WITH ADJUSTABLE VANES

CNH Industrial America LL...

1. A threshing system for an agricultural harvester, the threshing system comprising:a rotor comprising an elongated body having a longitudinal axis, the elongated body having a proximal end adapted to receive material from a feeding mechanism and a distal end opposite the proximal end;
a cage that surrounds at least a portion of the proximal end of the rotor, the cage comprising an inner surface spaced radially apart from the rotor to define a threshing space between the rotor and the cage;
a discharge housing that surrounds at least a portion of the distal end of the rotor, the discharge housing comprising a side wall spaced radially apart from the rotor to define a discharge passage between the rotor and the discharge housing; and
a plurality of adjustable vanes mounted to the side wall of the discharge housing at a downswept side of the rotor, each adjustable vane extending radially from the inner surface of the discharge housing and into the discharge passage, each vane being movable relative to an adjacent portion of the discharge housing between a first position in which the vane is at a first helical angle relative to the longitudinal axis and a second position in which the vane is at a second helical angle relative to the longitudinal axis to thereby change a trajectory of the material expelled from the discharge passage and out of the threshing system,
wherein the vanes are axially spaced apart from each other such that a space is formed between the vanes along which material can pass.

US Pat. No. 10,426,092

DUAL AUGER GRAIN CART WITH ADJUSTABLE FORWARD REACH

Unverferth Manufacturing ...

1. A cart for transporting and conveying agricultural materials comprising:a frame;
a set of wheels or tracks coupled with said frame;
a hitch assembly coupled with said frame to allow said cart to be towed on said wheels or tracks behind a tow vehicle;
a hopper defined by a plurality of walls supported by said frame and having a hopper opening to receive agricultural material and a discharge opening for discharging agricultural material;
a conveyor assembly coupled to the hopper, said conveyor assembly including an inlet in communication with said discharge opening to receive agricultural material therefrom and an outlet to discharge agricultural material, wherein said conveyor assembly includes a lower conveyor section and an upper conveyor section;
said lower conveyor section including a lower conveyor housing and a lower conveyor extending within said lower conveyor housing and said upper conveyor section including an upper conveyor housing and an upper conveyor extending within said upper conveyor housing; and
a tilting assembly coupled to an end of said lower conveyor housing;
wherein said upper conveyor section is pivotable about a second tilt axis located between said lower and upper conveyor sections and positioned at an acute angle from vertical; and
wherein said tilting assembly is configured to pivot said upper conveyor section about the second tilt axis between a first operating position in which a longitudinal axis of said upper conveyor section is generally collinear with a longitudinal axis of said lower conveyor section and a second operating position in which said longitudinal axis of said upper conveyor section is angled relative to said longitudinal axis of said lower conveyor section.

US Pat. No. 10,426,091

PICKUP REEL FOR A CROP HARVESTING HEADER

HONEY BEE MANUFACTURING L...

1. A crop harvesting header apparatus comprising:a pickup reel mounted for rotation about a reel axis within the header apparatus;
a plurality of reel bats peripherally disposed on the pickup reel about a reel axis, each reel bat having a plurality of outwardly extending fingers along a length of the reel bat, each reel bat being rotatable about a bat axis;
a non-circular cam track mounted adjacent to the pickup reel and surrounding the reel axis, the cam track being immobilized with respect to the header apparatus, the cam track including a cam surface and a guide surface;
a linkage associated with each reel bat and having first and second spaced apart cam followers disposed to engage the cam surface at first and second points of contact, the cam surface being configured to cause displacement of the linkage in a generally radial direction with respect to the reel axis while traversing the cam track during rotation of the pickup reel, the linkage being coupled to the reel bat such that the displacement of the linkage causes rotation of the reel bat about the bat axis for changing an angle of attack of the fingers to control movement of a crop through the header apparatus;
a guide follower disposed on the linkage for engagement of the guide surface at a third point of contact between the first and second points of contact; and
wherein an offset between the guide surface and the cam surface along the cam track is selected to cause each of the first and second cam followers to maintain contact with the cam surface and the guide follower to maintain contact with the guide surface while traversing the cam track.

US Pat. No. 10,426,089

FEEDER HAVING LATERAL TILT FOR AN AGRICULTURAL HARVESTING COMBINE

Tribine Industries LLC, ...

1. An improved feeder house assembly, which comprises:a front end header adapter assembly, comprising
(a) a front hook assembly for carrying a grainhead;
(b) a front header cradle assembly supporting the front hook assembly and comprising a pair of frame assemblies, each having mated top domed surfaces, one of the frame assemblies being stationary and the other frame assembly laterally tilting along the mated top domed surfaces along an arc of rotation by a pair of linear actuators located at either top side of the front end header adapter and connected to the other laterally tilting frame assembly tangential to the arc of rotation.

US Pat. No. 10,426,088

CENTER FEED ASSEMBLY FOR A DRAPER

1. A draper head for a combine, the draper header comprising:a center section adapted for attachment to the combine and provided with a center feed assembly, the center feed assembly including first and second belt frames each supporting a drive roller, an idler roller, and a belt extending between the drive roller and the idler roller; and
first and second wings extending in opposite lateral directions from the center section, each of the first and second wings including a draper belt operable to feed crop material toward the center section,
wherein the second belt frame is movable relative to the first belt frame.

US Pat. No. 10,426,087

USER INTERFACE PERFORMANCE GRAPH FOR OPERATION OF A MOBILE MACHINE

1. A computer-implemented method, comprising:detecting a first set of sensor signals output by at least one of a grain loss sensor and a yield sensor implemented with an agricultural machine;
generating productivity performance metric values, based on the first set of sensor signals;
detecting a second set of sensor signals output by an image processing system implemented with the agricultural machine;
generating quality performance metric values, based on the second set of sensor signals;
displaying, on a user interface display, a time continuous display including:
a productivity strip chart that visually identifies the productivity performance metric values along a timeline of operation of the agricultural machine, and
a set of quality strip charts, each quality strip chart visually identifying one of the quality performance metric values along the timeline of operation;
defining a productivity performance window including a range of productivity threshold values, based on the productivity performance metric values;
defining a quality performance window including a range of quality threshold values, based on the quality performance metric values;
displaying, on the user interface display, the productivity performance window along the productivity strip chart and the quality performance window along the set of quality strip charts of the time continuous display;
automatically generating a control signal that controls operation of the agricultural machine, with a corresponding adjustment that is automatically applied to one or more settings of a controlled system to maintain a desired level of operating performance, based on a determination that at least one of the productivity performance metric values deviates outside of the range of productivity threshold values or a determination that at least one of the quality performance metric values deviates outside of the range of quality threshold values;
displaying, on the user interface display, an indication of where, along the time continuous display, the control signal is automatically generated along the timeline of operation of the agricultural machine;
based on receiving a drill input, selecting one of the quality performance metric values and displaying a more detailed display indicative of more detailed information corresponding to the selected quality performance metric value derived from the second set of sensor signals, and wherein displaying a more detailed display comprises:
displaying, along the timeline and with one or more of the quality strip charts, a time continuous display for each of a plurality of additional metric values derived from the second set of sensor signals and associated with the selected quality performance metric value.

US Pat. No. 10,426,085

CENTRIFUGAL FAN ROTOR AND APPARATUS INCORPORATING THE CENTRIFUGAL FAN ROTOR

Crary Industries, Inc., ...

1. A centrifugal fan rotor comprising:a frame having a rotary axis; and
a plurality of blades on the frame at circumferentially spaced locations around the rotary axis,
the plurality of blades each having a leading edge and a trailing edge radially outside of the leading edge,
the plurality of blades each having circumferentially oppositely facing first and second surfaces each extending between respective leading and trailing edges,
the plurality of blades each having a thickness between respective first and second surfaces,
each of the first and second surfaces having an exposed area,
wherein the plurality of blades each has a material bonded on the leading edge and over only a portion of the exposed surface area of one of the first and second surfaces,
wherein the leading edge of each of the plurality of blades has an axial length and the material is bonded over only a portion of the axial length of the leading edge of each of the plurality of blades,
the thickness of each of the plurality of blades being substantially uniform over the portion of the exposed surface area of the one of the first and second surfaces to which the material is bonded.

US Pat. No. 10,426,084

MOWER CAPABLE OF EFFECTIVELY COOLING A MOTOR

KUBOTA CORPORATION, Osak...

1. A mower comprising:at least one rotationally driven grass cutting blade;
at least one motor having a motor housing and being configured to cause rotation of the grass cutting blade;
a mower deck having an upper surface and an outer wall that extends down from the upper surface, said outer wall and said upper surface defining an interior that houses the grass cutting blade;
at least a part of the motor extending into the interior of the mower deck;
at least another part of the motor extending above the upper surface of the mower deck;
at least one guide member surrounding and being spaced apart from a portion of the motor housing of said motor; and
said at least one guide member being located entirely in the interior of the mower deck and below the upper surface of the mower deck,
wherein an air flow from outside the mower deck moves radially inwards inside the interior of the mower deck towards a motor shaft and is guided by the at least one guide member,
wherein the outer wall of the mower deck surrounds the grass cutting blade and the at least one guide member, and
wherein the at least one guide member defines an annular air flow passage along an outside of the motor, said air flow passage connecting the interior and an exterior of the mower deck.

US Pat. No. 10,426,083

BLADE ASSEMBLY FOR A GRASS CUTTING MOBILE ROBOT

iRobot Corporation, Bedf...

1. A grass cutting mobile robot comprising:a drive system operable to navigate the robot about a mowable area; and
a blade assembly comprising a housing and a blade to cut vegetation on the mowable area, the blade comprising:
a first portion extending outwardly from the housing and defining a longitudinal axis, a proximal end of the first portion mounting the blade to the housing on a mounting axis at a non-parallel angle to a vertical axis;
a second portion extending from a distal end of the first portion at an angle to the longitudinal axis; and
a third portion extending from a distal end of the second portion in a direction parallel to the longitudinal axis, the third portion being offset by a distance from the first portion, and a distal end of the third portion being angled in a first direction with respect to the longitudinal axis and tapered in a second direction with respect to the longitudinal axis to form a blade cutting tip, the third portion of the blade comprising a cutting portion configured to cut the vegetation on the mowable area, the cutting portion of the blade being coincident with a radial axis of the blade assembly.

US Pat. No. 10,426,081

ATTACHABLE STORAGE DEVICE FOR A LANDSCAPE MACHINE

1. A landscaping machine comprising:a protective rollover bar having a left bar portion extending from a left side of an operator seat, a top bar portion extending from the left bar portion above the operator seat, and a right bar portion extending from the top bar portion to a right side of the operator seat;
a storage device attached to the protective rollover bar, wherein the storage device comprises a support bar extending between and attached to the left bar portion and the right bar portion; and
wherein the storage device includes a receptacle that is configured to hold loose objects during operation of the landscaping machine, wherein the receptacle comprises an inner storage cavity, and wherein the support bar is configured to rotate about at least one of the left bar portion and the right bar portion while remaining attached to the protective rollover bar such that an axis of rotation of the storage device is at least substantially parallel to at least one of the left bar portion and the right bar portion.

US Pat. No. 10,426,080

MOBILE TURF SPRAYER

The Toro Company, Minnea...

1. A method of spraying a turf site using a mobile turf sprayer, the method comprising:identifying a plurality of regions of a turf site to be sprayed with the mobile turf sprayer, at least some of the plurality of regions being separated from each other;
determining a location of the mobile turf sprayer as it moves about the turf site;
determining that the mobile turf sprayer is located at an unsprayed portion of at least one of the plurality of regions;
automatically spraying the unsprayed portion of the at least one of the plurality of regions as the mobile turf sprayer moves about the turf site;
generating a first user interface for a first user on a display device using a computing device, the first user interface providing a set of selectable options, the selectable options being associated with a set of available functions; and
generating a second user interface for a second user on the display device using the computing device, the second user interface providing a reduced set of selectable options, the reduced set of selectable options being associated with a reduced set of available functions, wherein the set of available functions are configured to control the reduced set of available functions.
US Pat. No. 10,429,385

TREATING CONDITIONS ASSOCIATED WITH SEPSIS

TLA TARGETED IMMUNOTHERAP...

1. A method for treating sepsis in a subject in need thereof, which comprises applying peripheral blood from the subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine CXCR1 receptor immobilized directly or indirectly on the support, whereby one or more cells expressing chemokine receptor CXCR1 are removed from the peripheral blood of the subject, wherein the applied blood is recirculated back into the systemic circulation of the subject, and whereby the sepsis is treated.
US Pat. No. 10,426,823

METHODS FOR CONSTRUCTING ANTIBIOTIC RESISTANCE FREE VACCINES

THE TRUSTEES OF THE UNIVE...

1. A composition comprising an antibiotic resistance gene-free plasmid, said plasmid comprising: i) a first nucleic acid sequence encoding a polypeptide, wherein said polypeptide is a fusion protein comprising a heterologous antigen and a non-hemolytic Listeriolysin (LLO) protein or N-terminal fragment thereof, and ii) a second nucleic acid sequence encoding a metabolic enzyme.
US Pat. No. 10,428,359

METHOD FOR PRODUCING L-AMINO ACID

AJINOMOTO CO, INC., Toky...

1. A method for producing an L-amino acid, the method comprising the steps of:A) culturing a bacterium having an L-amino acid-producing ability in a medium resulting in accumulation of an L-amino acid in the medium; and
B) collecting the L-amino acid from the medium;
wherein the bacterium has been modified so that the activity of a C4-dicarboxylic acid-uptake carrier is increased as compared with a non-modified bacterium,
wherein the C4-dicarboxylic acid-uptake carrier is a protein encoded by a gene selected from the group consisting of a dctA gene, a dcuA gene, a dcuB gene, and combinations thereof, and
wherein the L-amino acid is an L-amino acid other than L-aspartic acid,
provided that the L-amino acid is L-glutamic acid when the C4-dicarboxylic acid-uptake carrier is a protein encoded by a dctA gene, and
provided that the bacterium has further been modified so as to harbor a mutant yggB gene when the bacterium is a coryneform bacterium and the C4-dicarboxylic acid-uptake carrier is a protein encoded by a dctA gene.
US Pat. No. 10,429,129

METHOD OF MICROWAVE VACUUM DRYING SPHERICAL-SHAPED PELLETS OF BIOLOGICAL MATERIALS

1. A method of preparing a dried pellet of an enveloped live virus, comprising:a) dispensing an aliquot of a liquid composition comprising the enveloped live virus as a single droplet onto a solid surface, wherein the temperature of the solid surface is at ?90° C. or below, in a manner that maintains the droplet as a single droplet as it contacts and freezes on the surface as a frozen pellet;
b) applying microwave radiation in a traveling wave format at a power in a range of between 0.5 and 8 KW/hr/Kg to the frozen pellet under a pressure below atmospheric pressure to produce a dried pellet;wherein the drying yield, as obtained by a plaque assay, is greater than or equal to 50%.
US Pat. No. 10,429,386

ANTIBODIES TO THE SURFACE OF TOXOPLASMA GONDII OOCYSTS AND METHODS OF USE THEREOF

The Regents of the Univer...

1. A method of specifically detecting an intact Toxoplasma gondii oocyst in a sample, the method comprising:a) contacting a sample suspected of containing a T. gondii oocyst with an IgG monoclonal antibody that specifically binds a protein on the outer wall of an intact T. gondii oocyst under conditions sufficient to form an immunocomplex of the antibody with the intact T. gondii oocyst; and
b) specifically detecting the presence or absence of the immunocomplex comprising the antibody.
US Pat. No. 10,426,824

COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS

The General Hospital Corp...

1. A method of treating cancer in a single subject in need thereof comprising:(a) comparing:
(i) nucleic acid sequences obtained by whole genome sequencing or whole exome sequencing of cancer cells from the single subject to,
(ii) nucleic acid sequences obtained by whole genome sequencing or whole exome sequencing of non-cancer cells from the single subject;
(b) identifying a plurality of cancer specific nucleic acid sequences that are specific to the cancer cells of the single subject based on (a),
wherein the identified plurality of cancer specific nucleic acid sequences encodes two or more different peptide sequences of two or more different proteins that are expressed by the cancer cells, and
wherein each of the two or more different peptide sequences of the two or more different proteins comprise a cancer specific amino acid mutation that is not present in the non-cancer cells from the single subject;
(c) calculating binding affinities of the two or more different peptide sequences encoded by the plurality of cancer specific nucleic acid sequences identified in (b) to a protein encoded by an HLA allele of the single subject by an HLA peptide binding analysis using a program implemented on a computer system;
(d) selecting at least two peptide sequences calculated in (c) to have a binding affinity to a protein encoded by an HLA allele of the single subject with an IC50 of less than 500 nM;
(e) administering a pharmaceutical composition to the single subject, wherein the pharmaceutical composition comprises one or more polypeptides comprising the at least two peptide sequences selected in (d) or one or more polynucleotides encoding the at least two peptide sequences selected in (d).
US Pat. No. 10,428,104

SUBSTITUTED NUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS

Pfizer Inc., New York, N...

1. A compound selected from:(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methylphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-chloro-4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-methoxyphenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
5-((R)-((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)(hydroxy)methyl)-2-fluorobenzonitrile,
(2R,3S,4R,5R)-2-((R)-(2-(dimethylamino)pyridin-4-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indazol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(3-(trifluoromethyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(3S,4R,5R)-2-((3-fluoro-5-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-(trifluoromethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(3-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(4-(methylsulfonyl)phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-(difluoromethyl)benzofuran-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-6-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(1-(difluoromethyl)-1H-benzo[d]imidazol-5-yl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-1-hydroxy-2-(phenylsulfonyl)ethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-indol-6-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2((S)-1-hydroxy-2-phenylethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxy-3-phenylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3-chlorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(3,5-difluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxypropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclopentyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclopropyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-1-hydroxy-2-methylpropyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-hydroxy(1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-cyclobutyl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-furan-2-yl(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((1H-pyrazol-1-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(3S,4R,5R)-2-(difluoro(4-fluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxypropyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-hydroxybutyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-phenyltetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(oxazol-5-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-1-hydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(hydroxymethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(1H-pyrazol-5-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-hydroxy(phenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((R)-(4-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(1-methyl-1H-pyrazol-3-yl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(3-(ethoxymethyl)-1H-pyrazol-5-yl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-(1,2-dihydroxyethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
((3aS,4S,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxo1-4-yl)(2-(methylsulfonyl)phenyl)methanone,
(2R,3S,4R,5R)-2-((R)-hydroxy(1H-indol-7-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(5-fluoropyridin-2-yl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chlorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(S)-1-((3aR,4S,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethan-1-ol,
2-((3aR,4R,6R,6aR)-2,2-dimethyl-6-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propan-2-ol,
(3,4-difluorophenyl)((2S,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)methanone,
(2S,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)fluoromethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2S,3S,4R,5R)-2-((S)-(3,4-difluorophenyl)fluoromethyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(3,4-difluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((S)-amino(3,4-difluorophenyl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-(difluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-(difluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(5-fluoro-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2,4-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-(4-fluorobenzyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(4-fluorobenzyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-(3,4-difluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-1-(3,4-difluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-1-(4-chloro-3-fluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5S)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-1-(4-chloro-3-fluorophenyl)-1-hydroxyethyl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-(fluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(4-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(methylamino)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(6-methylpyridin-3-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(2-methylpyridin-4-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-hydroxy(1,2,3,4-tetrahydroisoquinolin-8-yl)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
6-((R)-((2R,3S,4R,5R)-3,4-dihydroxy-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-2-yl)(hydroxy)methyl)pyridin-2(1H)-one,
(2R,3S,4R,5R)-2-((R)-(4-fluoro-3-(hydroxymethyl)phenyl)(hydroxy)methyl)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(4-chloro-3-fluorophenyl)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-(3,4-difluorophenyl)(hydroxy)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3S,4R,5R)-2-((R)-amino(3,4-difluorophenyl)methyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol,
(2R,3R,4S,5R)-2-(2-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(3,4-difluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol, and
(2R,3R,4S,5R)-2-(2-amino-5-fluoro-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)tetrahydrofuran-3,4-diol acetate,
or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,428,360

LOV-D ACYLTRANSFERASE MEDIATED ACYLATION

Codexis, Inc., Redwood C...

1. A method of making simvastatin, comprising contacting monacolin J substrate with a LovD polypeptide having acyltransferase activity, wherein said LovD polypeptide is a recombinant variant comprising SEQ ID NO: 20, in the presence of an alpha-dimethylbutyryl thioester co-substrate, under conditions such that said monacolin J substrate is converted to simvastatin.
US Pat. No. 10,428,361

BIOCATALYTIC PRODUCTION OF L-FUCOSE

BASF SE, Ludwigshafen am...

1. A method for producing L-fucose, comprising the following steps:(a) providing L-fucitol, a galactose oxidase of the enzyme class EC 1.1.3.9, a peroxidase and a catalase,
(b) combining L-fucitol, the galactose oxidase, the peroxidase, and the catalase to form a mixture,
(c) incubating the resulting mixture under conditions permitting the biocatalytic oxidation of L-fucitol to L-fucose, and
(d) optionally isolating the synthesized L-fucose.
US Pat. No. 10,429,388

METHODS, DEVICES, KITS AND COMPOSITIONS FOR DETECTING ROUNDWORM, WHIPWORM AND HOOKWORM

Idexx Laboratories, Inc.,...

1. An immunocomplex comprising a first antibody specifically bound to a polypeptide, wherein the first antibody is capable of specifically binding to an amino acid sequence of SEQ ID NO:19-23, 38, or Copro6728.
US Pat. No. 10,426,827

DENGUE HEMORRHAGIC FEVER VIRUS VACCINE

MicroVAX, LLC, Warrenton...

1. A composition for generating a humoral and cellular immune response in an individual against four strains of the Dengue Hemorrhagic Fever Virus (DHFV) with the E antigenic protein of the DHFV, in the form of a multi expression vector mixture comprising twelve expression vectors each of which comprises an effective amount of a nucleic acid encoding a secretable fusion protein comprising one of twelve distinct epitopes SEQ ID NOS. 1-12 from Domain III of the E protein, wherein said twelve distinct epitopes comprise three separate fragments from each of said four strains, each of said twelve epitopes recognized and bound by Class I and Class II MHC capable to generate both neutralizing antibodies and CD8 effector T cells, and wherein each of said twelve epitopes is separately linked to the N-terminal end of the extracellular domain of a CD40 ligand to define one of twelve distinct sub-compositions, and to collectively define said multi-expression vector mixture composition that is potent to anticipate immunological escape to heterologous strains of the DHFV thereby providing protection against related but not identical DHFV viruses.
US Pat. No. 10,428,363

AMPLIFICATION METHODS TO MINIMISE SEQUENCE SPECIFIC BIAS

ILLUMINA CAMBRIDGE LIMITE...

1. A method for amplifying nucleic acid templates of different sequences comprising:a) amplifying nucleic acid templates on a solid support in the presence of an additive capable of increasing efficiency of amplification of GC rich nucleic acid templates or decreasing efficiency of amplification of AT rich nucleic acid templates, wherein a subset of nucleotide types are incorporated into copies of the templates at a lower efficiency compared to at least one other type of nucleotide, thereby producing a plurality of different copies; and
b) using the plurality of different copies as templates in a second cycle of amplification.
US Pat. No. 10,429,391

BIOMARKERS FOR CHOLANGIOCELLULAR CARCINOMA (CCC)

1. A method for identifying biomarkers for cholangiocellular carcinoma (CCC), comprising:a) collecting tumorous tissue samples and non-tumorous tissue samples from at least 5 patients with CCC;
b) comparing the tumorous tissue samples with the non-tumorous tissue samples by two-dimensional differential in-gel electrophoresis (2D-DIGE) and thereby identifying a first set of biomarker candidates for CCC showing different expression in tumorous tissue and non-tumorous tissue determined by statistical analysis;
c) comparing the tumorous tissue samples with the non-tumorous tissue samples by label-free liquid chromatography-mass spectrometry (LC-MS) and thereby identifying a second set of biomarker candidates for CCC showing different expression in tumorous tissue and non-tumorous tissue determined by statistical analysis;
d) comparing the first set of biomarker candidates obtained by 2D-DIGE according to step b) with the second set of biomarker candidates obtained by label-free LC-MS according to step c) and thereby identifying a third set of biomarker candidates for CCC showing different expression with both 2D-DIGE and label-free LC MS; and
e) performing an immunohistochemical analysis of the third set of biomarker candidates for CCC identified from step d) by comparing the expression of a respective biomarker candidate in the tumorous tissue of a subject with the expression of said respective biomarker candidate in non-tumorous tissue of the same subject and selecting one or more biomarkers for CCC that display a sensitivity of 40% or more.
US Pat. No. 10,426,829

VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY

Novavax, Inc., Gaithersb...

1. A vaccine composition comprising:(i) a nanoparticle comprising a non-ionic detergent core and a viral glycoprotein,
wherein the viral glycoprotein is associated with the core; wherein the non-ionic detergent is PS80 wherein the viral glycoprotein is an RSV F glycoprotein and the molar ratio of PS80 to viral glycoprotein is about 30:1 to about 60:1; and
(ii) a pharmaceutically acceptable buffer.
US Pat. No. 10,429,648

AUGMENTED REALITY HEAD WORN DEVICE

1. An augmented reality head worn device comprising;a. a curved transparent mirror,
b. a scanning light source defining a field of view,
c. a holographic optical element (HOE) adapted to provide exit pupil expansion to create an enlarged eye-box, and
d. at least one projection system for providing pixels optically mapped to a pixel density;
wherein modulated red, green and blue lasers and a MEMS mirror micro-scanner are utilized to encode a display video illumination through conditioning and focusing optics onto the HOE and the HOE corrects for optical aberrations, replicates an image signal to create hexagonally packed exit pupil eye-box spots which are then redirected toward the curved transparent mirror which in turn directs the hexagonally packed exit pupil eye-box spots into the enlarged eye-box wherein the hexagonally packed exit pupil spots create the enlarged eye-box.
US Pat. No. 10,428,366

COLLAGENASE ASSAY

University of South Flori...

1. A method of measuring bacterial collagenase activity in a sample, comprising:staining native collagen fibrils with a dye at saturation level, said collagen fibrils being dry or lyophilized, said dye being capable of stably staining said collagen fibrils;
suspending said dyed collagen fibrils in a collagenase substrate buffer;
incubating said dyed collagen fibril suspension at about 37° C., wherein bacterial collagenase activity results in digestion of said dyed collagen fibrils into smaller, dyed collagen particulates that can be readily observed in a resulting mixture;
filtering said mixture to retain said dyed collagen particulates, wherein said dyed collagen particulates are digested and collected in a resulting filtrate;
extracting said dye from said filtrate to determine an amount of said digested dyed collagen particulates;
measuring absorbance of said extracted dye to determine an amount of said digested collagen particulates;
wherein said native fibrils are not solubilized by acid or gelled by heat, and
wherein said native fibrils are Type I collagen found in an animal body.
US Pat. No. 10,428,111

CANCER TARGETING BY ANTI-EGFR PEPTIDES AND APPLICATIONS THEREOF

1. A liposomal composition, comprising:a molecule; and
a lipid phase comprising a phospholipid, a PEGylated phospholipid, and cholesterol with molar ratio of between 50:30:5 and 60:40:5,
wherein the molecule consists of a lipid conjugated to a peptide through at least one linker with a molar ratio of the peptide to the lipid of 1.2:1,
wherein the peptide includes an amino acid sequence selected from the group consisting of LTVSPWY (SEQ ID NO: 1), MYWGDSHWLQYWYE (SEQ ID NO: 2), FCDGFYACYADV (SEQ ID NO: 3), IHNRYNRFFYWY (SEQ ID NO: 4), PRWGDSHWLQYWYE (SEQ ID NO: 5), LMWGGSHWLEYWYE (SEQ ID NO: 6), GHWGDQHWLQYWYE (SEQ ID NO: 7), GWWGDSHWLQYWYE (SEQ ID NO: 8), LTVEPWL (SEQ ID NO: 9), LTVSPLWD (SEQ ID NO: 11), LTVTPWL (SEQ ID NO: 12), LTVQPWP (SEQ ID NO: 13), LTVSPWT (SEQ ID NO: 14), VLTVQPW (SEQ ID NO: 15), LTVSLWT (SEQ ID NO: 16), PGVIPWN (SEQ ID NO: 17), LTYQTWP (SEQ ID NO: 18), and ELYVSRL (SEQ ID NO: 19), and
wherein the molecule comprises a spacer at N-terminal or C-terminal of the peptide, said spacer is the amino acid sequence CGGG as set forth in SEQ ID NO: 10,
wherein the liposomal composition comprises a plurality of liposomes, the plurality of liposomes comprising the molecule with a density between 25 and 200 molecules per liposome.
US Pat. No. 10,429,394

MONOCLONAL ANTIBODIES AGAINST KIR2DS1

National University Corpo...

7. A monoclonal antibody to KIR2DS1 that is produced by at least one hybridoma selected from the group consisting of a hybridoma with Accession No. NITE BP-01853, a hybridoma with Accession No. NITE BP-01855, and a hybridoma with Accession No. NITE BP-01854 or a fragment comprising an antigen-binding region thereof.
US Pat. No. 10,428,113

COMPOSITIONS FOR EXPANDING REGULATORY T CELLS (TREG), AND TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND CONDITIONS

THE REGENTS OF THE UNIVER...


US Pat. No. 10,427,090

CONTROL OF SWING ADSORPTION PROCESS CYCLE TIME WITH AMBIENT CO2 MONITORING

PRAXAIR TECHNOLOGY, INC.,...

1. A method for maximizing the time an adsorbent bed can remain online in feed mode in a swing adsorption process without experiencing breakthrough of adsorbate, wherein said swing adsorption process comprises at least two adsorbent beds each having a predetermined design bed capacity, wherein one adsorber bed is online in feed mode during which adsorbate is adsorbed from a feed gas mixture passing through the bed, while another adsorbent bed is in regeneration mode, during which the adsorbed component is desorbed from the bed, wherein the beds alternate between said modes, said method comprising:a) Repeatedly measuring the feed gas flow rate, feed gas temperature, feed gas pressure and the concentration levels of adsorbate in said feed gas during the on-stream mode;
b) Calculating the perturbation front velocity of the adsorbate through the adsorbent bed when there is a an instantaneous variation of ambient levels of said adsorbate in the feed gas;
c) Calculating the breakthrough time of said adsorbate based on the perturbation front velocity of said adsorbate through the adsorbent bed, and
d) Updating the bed capacity and the online cycle time to maximize the time that the adsorbent bed can remain online in feed mode without experiencing breakthrough of said adsorbate.
US Pat. No. 10,428,116

RHINOVIRUS C IMMUNOGENIC PEPTIDES

Wisconsin Alumni Research...

1. A composition comprising a peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and a heterologous carrier protein, wherein the peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:1, 3, 6, 8, 11, 13, 15, 17, 19, 21, 23, 25, 27, 30, 33, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 57, 59, 61, 63, 65, 67, 48, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 117, 119, 121, 123, 125, and 127.
US Pat. No. 10,428,373

DUPLICATING DNA WITH CONTIGUITY BARCODES FOR GENOME AND EPIGENOME SEQUENCING

The Regents of the Univer...

1. A method for sequencing a template polynucleotide comprising:(a) contacting the template polynucleotide with a plurality of oligonucleotide pairs, wherein each member of each oligonucleotide pair comprises (i) an adaptor sequence, (ii) a unique barcode sequence that hybridizes to its complement on the other member of the oligonucleotide pair, and wherein one or both of the oligonucleotide pairs comprises (iii) a primer sequence that hybridizes to the template polynucleotide;
(b) contacting the template polynucleotide and plurality of oligonucleotide pairs with a polymerase lacking strand displacement activity and reagents necessary for polymerization, and
(c) allowing extension of a polynucleotide strand from the 3? end of the primer sequence to produce an extended polynucleotide comprising components (i)-(iii) and a sequence complementary to the template polynucleotide;
(d) collecting the extended polynucleotides;
(e) sequencing the extended polynucleotides; and
(f) assembling the sequences of the extended polynucleotides based on the unique barcodes, thereby sequencing the template polynucleotide,
wherein the method does not include fragmenting the template, damaging the polynucleotide or removing epigenetic markers on the template polynucleotide.
US Pat. No. 10,428,118

HUMAN CYTOMEGALOVIRUS COMPRISING EXOGENOUS ANTIGENS

1. A recombinant human cytomegalovirus (HCMV) comprising:(1) a nucleic acid encoding at least one heterologous antigen,
(2) an inactivating mutation in the UL82 gene, and
(3) active US2, US3, US6, US7, UL131A, and UL97 genes;
wherein the recombinant HCMV is a genetically modified TR strain of HCMV; and the recombinant HCMV is Ganciclovir sensitive.
US Pat. No. 10,426,839

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM

AXSOME THERAPEUTICS, INC....

1. A method of improving oral bioavailability of meloxicam in a human being, comprising orally administering a solid dosage form comprising both a bicarbonate and meloxicam to the human being, wherein the solid dosage form contains 400 mg to 900 mg of the bicarbonate, wherein the oral bioavailability of meloxicam for the solid dosage form in the human being is improved as compared with a first reference dosage form that: 1) contains the same amount of meloxicam; 2) does not contain the bicarbonate; and 3) does not contain a carbonate, or a second reference dosage form that: a) contains the same amount of meloxicam; b) does not contain the bicarbonate; and c) contains an amount of potassium carbonate that achieves about the same pH as the bicarbonate; wherein the solid dosage form has been shown to have a median Cmax that is about 1800 ng/mL to about 3000 ng/mL in fasted human subjects.
US Pat. No. 10,428,119

PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES

The United States of Amer...

1. A Pseudomonas exotoxin A (PE) comprising the amino acid sequence of Formula I:FCS-R1m—R2p—R3n-PE functional domain III   (Formula I),
wherein:
m, n, and p are, independently, 0 or 1;
FCS comprises a furin cleavage amino acid sequence;
R1 comprises 1 or more continuous amino acid residues of residues 285-293 of SEQ ID NO: 1;
R2 comprises X1VAX2X3X4AAX5LSW (SEQ ID NO: 2), wherein X1, X2, and X4 are independently leucine, alanine, glycine, serine, or glutamine; X3 is tyrosine, alanine, glycine, serine, or glutamine; and X5 is arginine, alanine, glycine, serine, or glutamine; with the proviso that the PE does not comprise LVALYLAARLSW (SEQ ID NO: 3) and that when X5 is alanine, at least one of X1, X2, X3, and X4 is alanine, glycine, serine, or glutamine;
R3 comprises 1 or more continuous amino acid residues of residues 306-394 of SEQ ID NO: 1; and
PE functional domain III comprises residues 395-613 of SEQ ID NO: 1 with a substitution of amino acid residue D463,
optionally with a substitution of one or more amino acid residues within one or more B-cell epitopes of SEQ ID NO: 1; and/or
optionally with a substitution of one or more amino acid residues within one or more T cell epitopes within amino acid residues R421, L422, L423, A425, R427, L429, Y439, H440, F443, L444, A446, A447, I450, amino acid residues at positions 464-519, R551, L552, T554, I555, L556, and W558 of SEQ ID NO: 1.
US Pat. No. 10,427,096

METHOD AND SYSTEM FOR CONTROLLING MERCURY EMISSIONS FROM COAL-FIRED THERMAL PROCESSES

ADA-ES, INC., Highlands ...

1. A method, comprising:providing a mercury-containing gas stream generated from a combustible source having native mercury and native halogens, wherein the mercury-containing gas stream comprises a vapor-phase mercury, a vapor-phase halogen, and first particulates;
introducing, into the mercury-containing gas stream, a reactive surface agent to collect at least most of the halogen and the mercury, wherein the reactive surface agent comprises second particulates, and wherein the second particulates comprise one or more of a clay and a carbon sorbent; and
thereafter removing the first and second particulates from the mercury-containing gas stream to form a treated stream, at least a portion of the vapor-phase mercury being removed from the mercury-containing gas stream with removal of the first and second particulates,
wherein at least one of the following is true:
(i) the mercury-containing gas stream comprises about 3.5 ppmw or less of a vapor-phase iodine;
(ii) in the mercury-containing gas stream, a molar ratio of the vapor-phase iodine to the vapor-phase mercury is no more than about 600;
(iii) at an air preheater outlet, a concentration of the vapor-phase iodine ranges from about 0.1 to about 10 ppmw; and
(iv) a concentration of the iodine is about 30 ppmw or less relative to a weight of a mercury-containing feed material producing the vapor-phase mercury.
US Pat. No. 10,428,376

RNA AMPLIFICATION AND OLIGONUCLEOTIDE LIBRARY PREPARATION

REGENTS OF THE UNIVERSITY...

1. A method of amplifying an RNA template, the method comprising:annealing a primer to the RNA template, the primer comprising:
a region complementary to a portion of the RNA template; and
a digestible oligonucleotide adapter comprising RNA, DNA, an RNA/DNA hybrid, LNA, PNA, an oligonucleotide comprising at least one modified nucleotide, at least a portion of a plasmid, or at least a portion of a virus;
synthesizing an oligonucleotide from the primer, thereby producing a product that comprises a nucleotide strand complementary to the RNA template having the digestible oligonucleotide adapter;
isolating at least a portion of the oligonucleotide; and
subjecting the isolated product to treatment that digests at least a portion of the digestible adapter but does not digest the nucleotide strand complementary to the RNA template.
US Pat. No. 10,431,451

METHODS AND APPARATUSES FOR INCREASING REACTOR PROCESSING BATCH SIZE

LAM RESEARCH CORPORATION,...

1. A method of increasing a reaction chamber batch size, the method comprising:(a) processing a portion of a batch of wafers within the reaction chamber, wherein the processing results in at least some off-target deposition of material on interior surfaces of the reaction chamber;
(b) without cleaning the chamber, conducting a mid-batch reaction chamber processing to stabilize the off-target deposition material accumulated on interior surfaces of the reaction chamber comprising depositing a dielectric film coating that binds to the material on the interior surfaces of the reaction chamber; and
(c) processing another portion of the batch of wafers within the reaction chamber.
US Pat. No. 10,428,121

NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B

Novartis AG, Basel (CH) ...

1. A fusion polypeptide consisting of (i) a polypeptide which has at least 95% sequence identity to SEQ ID NO: 4212 and (ii) a heterologous sequence.
US Pat. No. 10,428,123

CONSTITIUTIVE PROMOTER

Lonza Ltd, Visp (CH)

1. An expression construct comprising a pCS1 promoter which is any of:i) a promoter comprising the nucleic acid sequence identified as SEQ ID NO: 1, or
ii) a promoter which is a size variant of SEQ ID NO: 1 comprising a contiguous fragment of SEQ ID NO: 1 that has a length of at least 500 bp and includes the 3? terminus of SEQ ID NO: 1 wherein the size variant has at least 80% sequence identity to the contiguous fragment of SEQ ID NO: 1, which pCS1 promoter is operably linked to a nucleotide sequence encoding a protein of interest (POI), which pCS1 promoter is not natively associated with the nucleotide sequence encoding the POI.
US Pat. No. 10,426,844

CAPSID-MUTATED RAAV VECTORS AND METHODS OF USE

University of Florida Res...

1. A recombinant adeno-associated virus (rAAV) particle, comprising:(a) a mutated AAV2 VP3 capsid protein comprising phenylalanines at each of the positions corresponding to Y444, Y500 and Y730 in a wild type AAV2 VP3 capsid protein; and
(b) a rAAV nucleic acid vector comprising a 5? inverted terminal repeat (ITR), a transgene, and a 3? ITR.
US Pat. No. 10,428,125

CYSTINE KNOT SCAFFOLD PLATFORM

Genentech, Inc., South S...

1. A peptide that binds to vascular endothelial growth factor A (VEGF-A), and comprises the scaffold structure:Z1C1L1C2L2C3L3C4L4C5L5C6Z2 wherein:Z1 corresponds to the N-terminus of the peptide and is selected from the group consisting of: G, no amino acid, and X, wherein X is acetylglycine or PEG6-propargylglycine;
Z2 corresponds to the C-terminus of the peptide and is selected from the group consisting of G, no amino acid, L-serine, D-serine, X, wherein X is selected from the group consisting of: L-beta-homoserine, L-beta-alanine, N-alpha-methyl-glycine, glycine comprising amidated carboxyl group, glycine ester of glycerol, glycine ester of glycol, glycine ester of oxetane-3-yl, glycine amide, and glycine morpholine amide, GFH, GIA, GGS, GTR, GVH, GLS and amino acids 30-33 of any one of SEQ ID NOs: 369-378;
C1-C6 are cysteine residues; and
L1 is loop 1 , L2 is loop 2 , L3 is loop 3 , L4 is loop 4 , and L5 is loop 5;whereinL1 is selected from the group consisting of SEQ ID NOs: 33, 141, 143, 212, 213, 277, 396-404, 414, 416, 433, 434, and amino acids 3 to 8 of SEQ ID NO: 548;
L2 is selected from the group consisting of SEQ ID NO: 97, 418, and amino acids 12-16 of SEQ ID NOs: 538, 539, 540, and 541;
L3 is selected from the group consisting of LAG, LQQ, VER, MSD, MNQ, MQT, VYQ, FIN, VSQ, VTE, FYE, MEQ, LEQ, VYR, VSD, VSE, VSK, VSN, VSX, wherein X is ornithine, LAK, MED, MEE, MEK, MEN, and MEX wherein X is ornithine, LAX wherein X is ornithine, LSG, LTG, LEG, and XAG wherein X is selected from the group consisting of: t-butyl-L-alanine, cyclobutyl-L-alanine, cyclopentyl-L-alanine, and 5,5,5-trifluoro-L-leucine, and XEQ wherein X is selected from the group consisting of: norleucine, t-butyl-L-alanine, and cyclobutyl-L-alanine;
L4 is selected from the group consisting of: V, L, I, and X wherein X is selected from the group consisting of: norleucine, butyl-L-glycine, t-butyl-L-alanine, L-cyclopentylglycine, cyclopentyl-L-alanine, cyclobutyl-L-glycine, cyclobutyl-L-alanine, and 5,5,5-trifluoro-L-leucine; and
L5 is selected from the group consisting of SEQ ID NOs: 45, 220, 427, and 429; and
wherein C1 forms a disulfide bond with C4, C2 forms a disulfide bond with C3, and C5 forms a disulfide bond with C6.
US Pat. No. 10,426,846

OLIG1 MINI-PROMOTERS: PIE305

University of British Col...

1. An isolated polynucleotide comprising an OLIG1 mini-promoter wherein the OLIG1 mini-promoter comprises one or more OLIG1 regulatory elements with at least 95% sequence identity to one, two or all of SEQ ID NOs: 3-5 operably joined to an OLIG1 basal promoter with at least 95% sequence identity to SEQ ID NO: 2 through a non-native spacing between the regulatory elements and the basal promoter, wherein the OLIG1 mini-promoter has at least 95% sequence identity to SEQ ID NO: 1.
US Pat. No. 10,428,126

DERMASEPTIN-TYPE AND PISCIDIN-TYPE ANTIMICROBIAL PEPTIDES

The Regents of the Univer...

1. An antimicrobial peptide (AMP) comprising the amino acid sequence selected from the group consisting of: ALWMTLKKKVLKAKAKALNAVLKGANA (SEQ ID NO: 16); ALWMTLKKKVLKAKAKALNAVLAGVNA (SEQ ID NO: 17); and ALWMTLKKKVLKAKAKALNAVLVGLNA (SEQ ID NO: 19)or a pharmaceutically-acceptable salt thereof.
US Pat. No. 10,428,198

ULTRAVIOLET LIGHT ABSORBING MATRIX-MODIFIED LIGHT STABILIZING SILICA PARTICLES

International Business Ma...

1. A silica particle comprising:a silica matrix having an ultraviolet (UV) light absorbing material incorporated into the silica matrix; and
a light stabilizer material bonded to a surface of the silica matrix, the light stabilizer material comprising 4-(3-(dimethoxy(methyl)silyl)propoxy)-2,2,6,6-tetramethylpiperidine bonded to the surface of the silica matrix.
US Pat. No. 10,428,230

SYNERGISTIC MIXED SOLVENTS-BASED COMPOSITIONS WITH IMPROVED EFFICIENCY OF PERFORMANCE AND ENVIRONMENTAL SAFETY FOR REMOVAL OF PAINT, VARNISH AND STAIN

1. A non-aqueous composition for removing a paint or varnish coating from wood, metal or concrete surfaces which consists essentially of a mixture of environmentally acceptable mixed polar solvents consisting essentially of a first environmentally acceptable polar solvent selected from the group consisting of an ester amide, a lactone, an organic carbonate, a dialkyl sulfoxide, an alkyl imidazolidinone, an arylalkyl alcohol, and mixtures thereof, and a second environmentally acceptable polar solvent selected from the group consisting of an ester amide, a lactone, an organic carbonate, a dialkyl sulfoxide, an alkyl imidazolidinone, an arylalkyl alcohol, and mixtures thereof, wherein each of the first and second solvents have a Hansen's fractional polar solubility parameter component of greater than about 0.16 or 16% and at least one of the first or second solvents has a Hansen's fractional polar solubility parameter component of greater than about 0.25 or 25%; an activator; and optionally one or more additional environmentally acceptable polar solvents and optionally one or more additives chosen from rheology modifiers, bittering agents, fragrance, diluents, and/or emulsifiers, wherein the relative amounts of the first and second solvents are sufficient to cause an increase in the removal of coating of at least 5 percent compared to a composition containing either of the first or second solvents alone, and wherein the composition is devoid of N-methyl pyrrolidone.
US Pat. No. 10,431,325

METHODS TO IDENTIFY AMINO ACID RESIDUES INVOLVED IN MACROMOLECULAR BINDING AND USES THEREFOR

NOVARTIS AG, Basel (CH) ...

1. An in vitro method of producing a protein variant which exhibits increased binding to a macromolecule, the method comprisingreplacing or deleting one or more hot-spot amino acid residues in the protein by site-directed mutagenesis, wherein binding affinity of the modified protein to a macromolecule is increased, as compared to a corresponding protein lacking the replacement or deletion of one or more hot-spot amino acid residues,
(i) wherein the one or more hot-spot amino acid residues were identified using a computer-implemented method for predicting hot-spot amino acid residues of the protein, or portion thereof,
wherein the protein, or portion thereof, was represented in a structural model comprising a plurality of amino acid residues, and wherein
(i) a cluster of highly hydrophobic amino acid residues was selected from the plurality of amino acid residues of the model, wherein the cluster comprised two or more amino acid residues each having an effective-hydrophobicity greater than a chosen threshold, and wherein each amino acid residue in the cluster was within a first defined distance of at least one other amino acid residue in the cluster;
(ii) one or more solvent-exposed polar amino acid residues within a second defined distance of at least one amino acid residue in the cluster of highly hydrophobic amino acid residues was selected from the plurality of amino acid residues of the model;
(iii) amino acid residues that did not meet a criterion for evolutionary conservation were removed from the cluster of highly hydrophobic amino acid residues and from the one or more solvent-exposed polar amino acid residues, to produce a set of one or more predicted hot-spot amino acid residues; and
(iv) the one or more predicted hot-spot amino acid residues were stored;
wherein, if the hot-spot amino acid residue is replaced and is in the cluster of highly hydrophobic amino acid residues, it is replaced with an amino acid residue which is more hydrophobic such that the binding affinity is increases, or if the hot-spot amino acid residue is replaced and is from the one or more solvent-exposed polar amino acid residues, it is replaced with an amino acid residue which is more hydrophilic such that the binding affinity is increases.
US Pat. No. 10,427,995

MOLECULAR SIEVES MEDIATED UNSATURATED HYDROCARBON SEPARATION AND RELATED COMPOSITIONS, MATERIALS, METHODS AND SYSTEMS

CALIFORNIA INSTITUTE OF T...

1. A sieved hydrocarbon mixture obtained by separating an eight-membered monocyclic unsaturated hydrocarbon from a hydrocarbon mixture further comprising additional nonlinear unsaturated C8H2m hydrocarbons with 4?m?8,wherein separating the eight-membered monocyclic unsaturated hydrocarbon comprises
providing a 10-ring pore molecular sieve having a sieving channel with a 10-ring sieving aperture with a minimum crystallographic free diameter greater than 3 ? and a ratio of the maximum crystallographic free diameter to the minimum crystallographic free diameter between 1 and 2,
the 10-ring pore molecular sieve having a T1/T2 ratio?20:1 wherein T1 is an element independently selected from Si and Ge or a combination thereof, and T2 is an element independently selected from Al, B and Ga or a combination thereof,
the 10-ring pore molecular sieve further having a counterion selected from NH4+, Li+, Na+, K+ and Ca++ or a combination thereof, and
contacting the hydrocarbon mixture with the 10-ring pore molecular sieve at a temperature of ?20° C. to 60° C. for a time and under conditions to obtain a sieved hydrocarbon mixture comprising the eight-membered monocyclic unsaturated hydrocarbon at a separation concentration Cs>Ci,
wherein the 10-ring pore molecular sieve has a framework type selected from group consisting of MEL, TUN, IMF, MFI, OBW, MFS and TER, and
wherein, the sieved hydrocarbon mixture comprises the eight-membered monocyclic unsaturated hydrocarbon at a separation concentration Cs?99.3% wt.
US Pat. No. 10,428,251

TWO-PART POLYURETHANE ADHESIVES MADE USING ISOCYANATE-TERMINATED QUASI-PREPOLYMERS BASED ON POLY(BUTYLENE OXIDE)

Dow Global Technologies L...

1. A two-component polyurethane adhesive composition having a polyol component and an isocyanate component, wherein:the polyol component includes:
a) at least 35 weight percent, based on the weight of the polyol component, of one or more polyether polyols having a hydroxyl equivalent weight of 400 to 2000 and a nominal hydroxyl functionality of 2 to 4, which polyether polyols(s) are selected from homopolymers of propylene oxide and copolymers of 70 to 99% by weight propylene oxide and correspondingly 1 to 30% by weight ethylene oxide;
b) 5 to 20 parts by weight, per 100 parts by weight of ingredient a) of the polyol component, of one or more diol chain extenders;
c) 0.1 to 3 parts by weight, per 100 parts by weight of ingredient a) of the polyol component, of at least one compound having at least two primary and/or secondary aliphatic amine groups;
d) a catalytically effective amount of at least one urethane catalyst; and
e) up to 60 weight percent, based on the weight of the polyol component, of at least one particulate filler;
and the polyisocyanate component includes:
15 to 60 weight percent, based on the weight of the polyisocyanate component, of at least one isocyanate-terminated poly(butylene oxide) prepolymer having at least 2 isocyanate groups per molecule and an isocyanate equivalent weight of 700 to 3500, a poly(butylene oxide) segment having a weight of 1000 to 6000 g/mol;
20 to 50 weight percent, based on the weight of the polyisocyanate component, of at least one polyisocyanate compound having an isocyanate equivalent weight of up to 350 and 2 to 4 isocyanate groups per molecule; and
up to 50% by weight of at least one particulate filler;
wherein the isocyanate equivalent weight of the polyisocyanate component and the equivalent weight per isocyanate-reactive group of the polyol component are such that when the polyisocyanate component and the polyol component are mixed at a 1:1 ratio by volume the isocyanate index is 1.1 to 1.8.
US Pat. No. 10,426,716

COMPOSITIONS AND METHODS FOR IMPROVING COLOR DEPOSIT AND DURABILITY OF COLOR IN ARTIFICIALLY COLORED HAIR

1. A hair coloring composition comprising, in a cosmetically acceptable solvent:(a) above 0 wt. % to about 50 wt. % of one or more divalent metal salts of an inorganic acid chosen from salts of calcium, zinc, iron, nickel, copper, silver, magnesium, strontium, barium, manganese, cobalt, and mixtures thereof;
(b) above 0 wt. % to about 50 wt. % of one or more monovalent or divalent metal salts of an organic acid, wherein
the one or more divalent metal salts of an organic acid are chosen from salts of calcium, zinc, iron, nickel, copper, silver, magnesium, strontium, barium, manganese, cobalt, and mixtures thereof,
the one or more monovalent metal salts of an organic acid are chosen from salts of lithium, sodium, potassium, copper, silver, and mixtures thereof, and
the organic acid of the one or more monovalent or divalent metal salts of an organic acid is chosen from C1 to C9 monocarboxylic or di-carboxylic acids, polycarboxylic acids, hydroxy-carboxylic acids, and fatty acids having at least 10 carbon atoms; and
(c) one or more colorants chosen from oxidative dye precursors, direct dyes, pigments, and mixtures thereof.
US Pat. No. 10,427,996

FERMENTATION HYDROCARBON GAS PRODUCTS SEPARATION VIA MEMBRANE

Braskem S.A., Camacari (...

1. A method of separating and purifying a fermentation product directly from a fermenter off-gas containing the fermentation product, volatile impurities and bio-byproduct impurities, comprising the steps of: (a) compressing the fermenter off-gas to produce a compressed off-gas on a multi-stage compressor system wherein the bio-byproduct impurities and water are removed, and feeding the compressed off-gas into at least one membrane module comprising a membrane, and (b) selectively permeating the volatile impurities through the membrane, resulting in a retentate stream rich in the fermentation product.
US Pat. No. 10,428,252

TWO-COMPONENT COMPOSITION

SIKA TECHNOLOGY AG, Baar...

1. A composition comprising a first component and a second component, comprisingat least one silane group-containing polymer, liquid at room temperature,
at least one liquid epoxy resin,
at least one polyetheramine, and
at least one amino- or mercaptosilane,
the polyetheramine and the amino- or mercaptosilane not being present in the same component as the liquid epoxy resin, and
90% or more of groups reactive with an epoxide group are from the at least one polyetheramine and the at least one amino- or mercaptosilane.
US Pat. No. 10,426,719

ORAL CARE COMPOSITIONS AND METHODS FOR WHITENING TEETH

Colgate-Palmolive Company...

1. An oral care composition, comprising:a perhydrolase enzyme that catalyzes the generation of peracetic acid between a source of hydrogen peroxide and an acyl donor, wherein the enzyme comprises an amino acid sequence comprising a CE-7 signature motif and has at least 80% amino acid sequence identity to SEQ ID NO: 1 or the enzyme comprises a CE-7 signature motif that aligns with SEQ ID NO: 2, the CE-7 signature motif comprising a) an RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2: b) a GXSQG (SEQ ID NO: 3) motif at positions corresponding to positions 179-183 of SEQ ID NO: 2 and an HE motif at positions corresponding to positions 298-299 of SEQ ID NO:2; and
an anhydrous matrix configured to at least partially stabilize the perhydrolase enzyme, wherein the anhydrous matrix comprises said source of hydrogen peroxide, said acyl donor, a non-aqueous anhydrous liquid, and a thickener;
wherein the non-aqueous anhydrous liquid comprises a polyethylene oxide-polypropylene oxide block copolymer;wherein the oral care composition is a single phase composition.
US Pat. No. 10,427,999

PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE

HONEYWELL INTERNATIONAL I...

1. A composition comprising (i) at least 50% by weight 1,1,1,2,3-pentafluoropropane (245eb), (ii) 1,1,1,2,3,3-hexafluoropropane (236ea) and (iii) 1,2,3,3,3-pentafluoropropene (1225ye), wherein the composition comprises less than 2% by weight each of 1,1,1,2,3,3-hexafluoropropane (236ea) and 1,2,3,3,3-pentafluoropropene (1225ye).
US Pat. No. 10,426,720

FILM COMPOSITIONS FOR ORAL USE

Colgate-Palmolive Company...

1. An oral care composition comprising:(i) flakes of a water dissolvable or soluble film comprising:
(a) about 15 to about 40% by weight of a water soluble cellulose polymer in the form of a polymer matrix, wherein the cellulose polymer is hydroxypropylmethyl cellulose; and
(b) a dye which is entrapped in a silica sol-gel, wherein the silica sol-gel is entrained in the polymer matrix, and
(c) betaine; and
(ii) an orally acceptable carrier vehicle,
wherein the film flakes are single-layer film flakes and are pliable;
wherein the hydroxypropylmethyl cellulose is a blend of a first hydroxypropylmethyl cellulose having a viscostity ranging from 4 to 6 mPas, and a second hydroxypropylmethyl cellulose having a viscosity ranging from 40 cps to 60 mPas; and
wherein the first and second hydroxylpropylmethyl cellulose are present in a weight ratio of about 1:1.
US Pat. No. 10,428,001

FILM OZONOLYSIS IN A TUBULAR OR MULTITUBULAR REACTOR

P2 SCIENCE, INC., Woodbr...

1. A method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using an industrial scale tubular falling film reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current, and wherein the ozonolysis occurs continuously without accumulation of large amounts of hazardous intermediates, and wherein the tubes are cooled by flow of a coolant; andwherein the gas flow rate is from 10 to 1500 L/min in each of said tube or tubes.
US Pat. No. 10,426,722

COMPOSITIONS CONTAINING AN ALKYLATED SILICONE ACRYLATE COPOLYMER

1. A liquid lip composition, comprising:at least one alkylated silicone acrylate copolymer in an amount of from about 20% to about 50% by weight based on a total weight of the composition;
at least one coloring agent, and
at least one non-volatile oil in an amount of from about 5% to 60% by weight based on the total weight of the composition,
wherein the composition is anhydrous and has a gloss value at 20° angle of 10 or greater.
US Pat. No. 10,426,979

AEROSOL HAIRSPRAY PRODUCT FOR STYLING AND/OR SHAPING HAIR

The Procter and Gamble Co...

1. An aerosol hairspray product for styling and/or shaping hair wherein the product comprises:i. a container comprising a container wall which encloses a reservoir for storing a hairstyling formulation and a propellant;
ii. the hairstyling formulation comprising:
(a) from about 50% to about 99% water by total weight of the hairstyling formulation and propellant;
(b) from about 2% to about 12% of a neutralized hairstyling polymer by total weight of the hairstyling formulation and propellant, wherein the neutralized hairstyling polymer is an acrylate co-polymer;
(c) less than 0.5% of a cationic surfactant by total weight of the hairstyling formulation and propellant; and
iii. a propellant, wherein the propellant is dimethylether; and
iv. a spraying device attached to the container for dispensing the hairstyling formulation from the reservoir of the container;
wherein the hair styling formulation is free of ethanol; and
wherein the hairstyling formulation is fully dissolved.
US Pat. No. 10,426,726

MEDICAL CHEWING GUM

1. A medical chewing gum comprising gum base components, chewing gum components, gum base polymers as part of the gum base components and nicotine,wherein the gum base polymers of the chewing gum are synthetic,
the gum base polymers comprising a combined amount of polyvinyl acetate and vinyl laurate-vinyl acetate copolymer of more than 90% by weight of the gum base polymers,
wherein the combined amount of polyvinyl acetate and vinyl laurate-vinyl acetate copolymer includes 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, and
wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin,
whereby nicotine release is increased compared to a conventional nicotine chewing gum comprising natural resins having a similar level of burning.
US Pat. No. 10,428,262

NANOPARTICLE MODIFIED FLUIDS AND METHODS OF MANUFACTURE THEREOF

BAKER HUGHES, A GE COMPAN...

1. A nanoparticle modified fluid comprising:first nanoparticles that are surface modified to increase a viscosity of the nanoparticle modified fluid and that have at least one dimension that is less than or equal to about 100 nanometers;
second nanoparticles that are surface modified to increase a viscosity of the nanoparticle modified fluid and that have at least one dimension that is less than or equal to about 100 nanometers, the first nanoparticles being different from the second nanoparticles, the first and second nanoparticles having different functional groups, wherein the first nanoparticles are surface modified with epoxy groups and the second nanoparticles are surface modified with carboxyl groups; and
a liquid carrier comprising water;
wherein
the first and second nanoparticles each independently comprises carbonaceous nanoparticles, metal oxide nanoparticles, metal nanoparticles, polyhedral oligomeric silsesquioxane nanoparticles, clay nanoparticles, silica nanoparticles, boron nitride nanoparticles or a combination comprising at least one of the foregoing nanoparticles provided that where at least one of the first and second nanoparticles are the carbonaceous nanoparticles comprising carbon nanotubes, graphite nanoparticles, graphene nanoparticles, fullerenes, or a combination comprising at least one of the foregoing carbonaceous nanoparticles;
at least one of the first and second nanoparticles has an aspect ratio greater than 5;
the nanoparticle modified fluid exhibits a viscosity above that of a comparative nanoparticle modified fluid that contains the same nanoparticles but whose surfaces are not modified, when both nanoparticle modified fluids are tested at the same shear rate and temperature; and
the sum of the weight of the first and second nanoparticles is about 0.1 to about 2 wt. %, based on the total weight of the nanoparticle modified fluid, and the nanoparticle modified fluid has a viscosity increase of about 2 to about 6 orders of magnitude when the shear rate is decreased from 1,000 seconds?1 to 0.1 second?1.
US Pat. No. 10,426,728

SYNERGISTIC LIPOSOMAL FORMULATION FOR THE TREATMENT OF CANCER

Council of Scientific and...

1. A synergistic liposomal formulation for the treatment of cancer, wherein said synergistic liposomal formulation consists of drug-free phosphatidylcholine (PC) and stearylamine (SA) liposomes, and camptothecin (CPT), doxorubicin (DOX), or combinations thereof, and wherein phosphatidylcholine, stearylamine, and camptothecin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.7(CPT) or wherein phosphatidylcholine, stearylamine, and doxorubicin w/w molar ratio in said synergistic liposomal formulation is 7(PC):2(SA):0.5(DOX).
US Pat. No. 10,428,521

MASONRY BLOCK HAVING A CAVITY WEB

King Fahd University of P...

1. A masonry block with a cavity web, comprising:5-10 wt % cement;
75-80 wt % of an aggregate, which is not crumb rubber;
5-8 wt % water;
5-10 wt % crumb rubber relative to the total weight of the masonry block;
wherein the crumb rubber is in the form of coarse particles having a particle size of 1.5-5 mm, fine particles having a particle size of 50-250 ?m, or a mixture of the coarse particles and the fine particles; and
at least one of cement kiln dust and limestone powder, wherein the limestone powder has an average particle size of from 1 to 50 ?m,
wherein the aggregate is at least one selected from the group consisting of a crushed recycled concrete material and crushed limestone having an average particle size of greater than 1 millimeter, and
wherein the masonry block has a rectangular form with a front face, a back face, a first end face and a second end face forming a face perimeter surrounding a plurality of interior cavities separated by a web.
US Pat. No. 10,431,851

NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY AND METHOD FOR MANUFACTURING THE SAME

NISSAN MOTOR CO., LTD., ...

1. A non-aqueous electrolyte secondary battery comprising a power generating element including:two electrodes having different polarities, each of the electrodes including an active material layer formed on a current collector; and
an electrolyte layer positioned between the electrodes,
wherein the active material layer of at least one of the electrodes contains an active material and a conductive member made from an electron conducting material,
the active material layer has a first principal surface which comes into contact with the electrolyte layer, and a second principal surface which comes into contact with the current collector,
at least a part of the conductive member forms a conductive path electrically connecting the first principal surface to the second principal surface, and the conductive path is in contact with the active material in a periphery of the conductive path,
at least a part of a surface of the active material is coated with a coating agent that includes a coating resin and a conduction assisting agent,
an electrolyte solution contained in the electrolyte layer or the electrodes is a gel phase electrolyte,
the coating resin has a tensile elongation at break of 10% or more in a saturated liquid absorption state, and
the active material layer of at least one of the electrodes does not contain a binder.
US Pat. No. 10,426,731

METHODS OF PROCESSING FETAL SUPPORT TISSUES, FETAL SUPPORT TISSUE POWDER PRODUCTS, AND USES THEREOF

TISSUETECH, INC., Miami,...

1. A fetal support tissue powder product produced by a process consisting essentially of:a) first, lyophilizing a fetal support tissue comprising amniotic membrane, chorion, or a combination thereof from frozen or previously frozen placenta to produce lyophilized fetal support tissue; and
b) second, grinding the lyophilized fetal support tissue to generate a fetal support tissue powder product.
US Pat. No. 10,428,271

COMPOSITIONS AND METHODS FOR SELECTIVELY ETCHING TITANIUM NITRIDE

Entegris, Inc., Billeric...

1. A composition comprising: at least one oxidizing agent, an etchant, at least one activator present in an amount ranging from about 0.01 percent to about 10 percent by weight, and at least one solvent, wherein the at least one activator comprises a species selected from the group consisting of acetic acid, ammonium acetate, sodium acetate, potassium acetate, phosphonium acetate, ammonium butyrate, ammonium trifluoroacetate, amino acids, phosphoric acid, diammonium monohydrogen phosphate, ammonium dihydrogen phosphate, bis(tetramethylammonium) monohydrogen phosphate, disodium monohydrogen phosphate, sodium dihydrogen phosphate, dipotassium monohydrogen phosphate, potassium dihydrogen phosphate, ditetraalkylammonium monohydrogen phosphate, ditetraalkylammonium dihydrogen phosphate, diphosphonium monohydrogen phosphate, phosphonium dihydrogen phosphate, ammonium phosphonate, sodium phosphonate, potassium phosphonate, phosphonium phosphonate, and combinations thereof, wherein when in contact with a surface of a microelectronic device, the composition selectively removes titanium nitride and/or photoresist material from the surface of the microelectronic device without removing low-k dielectric material.
US Pat. No. 10,431,347

MASTERBATCHES FOR PREPARING COMPOSITE MATERIALS WITH ENHANCED CONDUCTIVITY PROPERTIES, PROCESS AND COMPOSITE MATERIALS PRODUCED

1. A masterbatch for use in a process of preparing a composite material, the masterbatch comprising a blend of a first amorphous polymer with carbon nanotubes, at least 5% by weight of carbon nanotubes based on the total weight of the masterbatch as determined according to ISO 11358, and having a high load melt flow index HLMI1 of less than 40 g/10 min determined at 200° C. under a load of 21.6 kg according to ISO1133, the masterbatch being characterized in that the first amorphous polymer has a melt flow index MFI1 of at least 10 g/10 min determined at 200° C. under a load of 5 kg according to ISO1133H, wherein the first amorphous polymer is selected from the group consisting of polystyrene, modified-polystyrene, acrylonitrile-butadiene-styrene, polycarbonate, styrene acrylonitrile, poly(methyl methacrylate), poly(vinyl chloride), polybutadiene, polybutylene terephthalate, poly(p-phenylene oxide), polysulfone, polyethersulfone, polyethylenimine, polyphenylsulfone, acrylonitrile styrene acrylate and any combination thereof, wherein the masterbatch comprises at least 80% by weight of the first amorphous polymer, and wherein the masterbatch comprises a surface resistivity of at most 1×102 Ohm/sq as determined according to CEI 60167.
US Pat. No. 10,429,300

SURFACE PLASMON RESONANCE APPROACH TO MONITOR PROTEIN-LIGAND INTERACTIONS

The Johns Hopkins Univers...

1. A method of identifying a ligand that binds to a paddle motif peptide, the method comprising:a) contacting a paddle motif peptide immobilized on a sensor chip with a test molecule, wherein the paddle motif peptide comprises SEQ ID NO: 2 or SEQ ID NO: 4;
b) detecting binding of the ligand and the paddle motif peptide using surface plasmon resonance (SPR), thereby identifying the test molecule as a ligand that binds the paddle motif peptide.
US Pat. No. 10,426,738

POLYNUCLEOTIDES ENCODING METHYLMALONYL-COA MUTASE

ModernaTX, Inc., Cambrid...

1. A messenger RNA (mRNA) comprisingan open reading frame (ORF) encoding the human methylmalonyl-CoA mutase (MCM) polypeptide of SEQ ID NO:213, wherein the ORF is at least 99% identical to the nucleotide sequence of SEQ ID NO:732.
US Pat. No. 10,427,251

FINE SILVER PARTICLE DISPERSION, FINE SILVER PARTICLES, AND METHOD FOR PRODUCING SAME

BANDO CHEMICAL INDUSTRIES...

1. A fine silver particle dispersion, which comprisesfine silver particles,
a short chain amine having 5 or less carbon atoms and
a highly polar solvent,
wherein a partition coefficient log P of the short chain amine is ?1.0 to 1.4 and
wherein the short amine is an alkoxyamine.
US Pat. No. 10,428,023

HETEROCYCLIC COMPOUND AND USE THEREOF

Takeda Pharmaceutical Com...

1. N-((2S,3S)-1-(2-hydroxy-2-methylpropanoyl)-2-((2,3?,5?-trifluorobiphenyl-3-yl)methyl)pyrrolidin-3-yl)methanesulfonamide or a salt thereof.
US Pat. No. 10,428,279

ELECTROLYZED WATER-AMINE COMPOSITIONS AND METHODS OF USE

1. A method of killing sulphate reducing microorganisms or microorganisms which can generate hydrogen sulphide, comprising the step of contacting the microorganism with a treatment fluid comprising a reaction product of electrolyzed water and an amine.
US Pat. No. 10,429,306

SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS DEVICE AND SURFACE PLASMON RESONANCE FLUORESCENCE ANALYSIS METHOD

KONICA MINOLTA, INC., To...

1. A surface plasmon resonance fluorescence analysis device to which an analysis chip including a prism having a metal film provided on one surface of the prism is attached, and in which the metal film is irradiated with excitation light through the prism to excite a fluorescence material for labelling a substance to be detected on the metal film and fluorescence emitted from the fluorescence material is detected to detect presence or an amount of the substance to be detected, the surface plasmon resonance fluorescence analysis device comprising:a chip holder configured to detachably hold the analysis chip;
a light source configured to emit excitation light;
an angle adjusting section configured to adjust an incident angle of the excitation light with respect to the metal film to irradiate the metal film with the excitation light through the prism at a predetermined incident angle;
a first light sensor configured to detect fluorescence emitted from the fluorescence material;
a light reception optical system configured to guide light emitted from the metal film to the first light sensor;
an excitation light reflection filter disposed in the light reception optical system, and configured to reflect light having a wavelength same as that of the excitation light emitted from the light source in the light emitted from the metal film;
a second light sensor configured to detect the light reflected by the excitation light reflection filter; and
a control section configured to control the angle adjusting section; wherein
the control section controls the incident angle of the excitation light with respect to the metal film to be adjusted by the angle adjusting section on a basis of a detection result of the light obtained by the second light sensor.
US Pat. No. 10,428,281

TRANSITION METAL TUNGSTEN OXY-HYDROXIDE

UOP LLC, Des Plaines, IL...

1. A conversion process comprising contacting a feed with a catalyst at conversion conditions to give at least one product, the catalyst comprising the decomposition product of the decomposition by sulfidation of a metal tungsten oxy-hydroxide material having the formula:Sa(NH4)bM(OH)xWyOz where ‘S’ is a sugar selected from glucose, fructose, galactose, lactose, maltose, sucrose, and mixtures thereof; ‘a’ varies from 0.001 to 5; ‘b’ varies from 0.1 and 3 ‘M’ is a metal selected from Mg, Mn, Fe, Co, Ni, Cu, Zn, and combinations thereof; ‘x’ varies from 0.1 to 2; ‘y’ varies from 0.1 to 4; z is a number which satisfies the sum of the valences of M, b, x and y; the material having a poorly crystalline diffraction pattern showing a broad peak between d-spacing 4.45-2.25 ?.
US Pat. No. 10,427,003

GOLF BALL HAVING AT LEAST ONE LAYER CONSISTING OF A MIXTURE OF A THERMOSET OR THERMOPLASTIC COMPOSITION AND A PLURALITY OF ALKOXYLATED SILOXANE-SURFACE TREATED PARTICLES AND/OR POLYETHER-MODIFIED SILOXANE-SURFACE TREATED PARTICLES

Acushnet Company, Fairha...

1. A golf ball having a CoR of at least 0.700 and an Atti compression of at least about 50 and comprising at least one layer comprising a mixture of a polyurethane composition and a plurality of titanium dioxide particulates, wherein at least a portion of the plurality is surface-treated with alkoxylated siloxanes, polyether-modified siloxanes, or combinations thereof;wherein the plurality of titanium dioxide particulates is included in the mixture in an amount such that the cover layer has a specific gravity of from 0.5 to about 5.0 and greater than a specific gravity of the polyurethane composition; and
wherein the plurality of titanium dioxide particulates creates a specific gravity gradient within the cover layer.
US Pat. No. 10,428,283

REACTOR WITH STRIPPING ZONE

UOP LLC, Des Plaines, IL...

1. A hydrotreating process comprising:providing a feed stream to a hydrotreating vessel, where the hydrotreating vessel comprises an upper zone, an intermediate zone and a lower zone;
passing the feed stream through the upper zone of the hydrotreating vessel, wherein the upper zone includes at least one upper catalyst bed;
separating a gas from a liquid within the intermediate zone;
passing the gas separated within the intermediate zone out of the hydrotreating vessel, said step of passing the separated gas comprises passing the separated gas through a heat exchanger and separating the vapor and liquid phase in a separator and routing liquid effluent from the separator back to said intermediate zone of the hydrotreating vessel;
providing a stripping gas to the lower zone through a first gas line;
replacing gas separated within the intermediate zone in the lower zone with a replacement gas via a second gas line in the lower zone; and
passing the liquid within the intermediate zone to the lower zone, wherein the lower zone includes a packed section wherein the liquid is contacted in counter current fashion with the stripping gas to remove impurities;
passing the liquid through to at least one lower catalyst in the lower zone,
wherein the step of removing impurities involves removing hydrogen sulfide and ammonia; and further wherein the hydrogen sulfide and the ammonia are passed out of the hydrotreating vessel during said step of passing the gas separated out of the hydrotreating vessel.
US Pat. No. 10,426,748

COMPOSITIONS AND METHODS FOR TREATING CHRONIC INFLAMMATION AND INFLAMMATORY DISEASES

Infirst Healthcare Limite...

1. A pharmaceutical composition comprising:a) a therapeutically effective amount of an ibuprofen;
b) less than about 20% by weight of the composition of a pharmaceutically-acceptable liquid polyethylene glycol (PEG) polymer; and
c) at least 50% by weight of the composition of pharmaceutically-acceptable glycerolipids comprising monoglycerides, diglycerides, and triglycerides;
wherein the pharmaceutical composition is formulated to have a melting point temperature of about 25° C. or higher.
US Pat. No. 10,427,004

GOLF BALLS INCORPORATING THERMOPLASTIC BLENDS(S) OF IONOMER(S), THERMOPLASTIC POLYMER(S), PGM REACTIVE CROSSLINKER(S), AND CATALYST(S)

Acushnet Company, Fairha...

1. A golf ball comprising a core and at least one layer comprising a thermoplastic blend of (i) at least one ionomer; (ii) at least one thermoplastic polyurethane; (iii) at least one reactive crosslinker consisting of maleic group-modified polymer(s), glycidyl (meth)acrylate-modified polymer(s), or combinations thereof (“PGM”); and (iv) at least one catalyst;wherein the ionomer is present in an amount of about 45 wt % or greater and the PGM is present in an amount of from about 2 wt % to about 35 wt %.
US Pat. No. 10,427,006

GOLF BALL INCORPORATING AT LEAST ONE LAYER OF PLASTICIZED NEUTRALIZED ACID POLYMER COMPOSITION CONTAINING LOW MOLECULAR WEIGHT ACID WAX(ES) AS SOLE ACID POLYMER COMPONENT AND LOW MOLECULAR WEIGHT NON-ACID WAX(ES) IN THE NON-ACID POLYMER COMPONENT

Acushnet Company, Fairha...

1. A golf ball comprising at least one layer consisting of a plasticized neutralized acid polymer composition consisting of a mixture of: (a) at least one low molecular weight acid-containing wax; (b) at least one non-acid-polymer, of which at least one is a low molecular weight non-acid wax; (c) at least one organic acid or salt thereof; and (d) at least one plasticizer;wherein each low molecular weight acid-containing wax has a molecular weight of from about 500 to about 30,000;
wherein the mixture contains at least 70 percent of neutralized acid groups; and
wherein the mixture has a melt flow index of at least 0.5 g/10 min.
US Pat. No. 10,427,007

GOLF BALL COMPOSITIONS

Acushnet Company, Fairha...

1. A golf ball comprising an innermost core layer formed from a heterogeneous composition comprising a thermoplastic matrix and discrete particles dispersed within the matrix, wherein the discrete particles are formed from a crosslinked rubber composition having a Shore D hardness of 65 or greater, and wherein each of the discrete particles present in the composition has a particle size of from 0.030 mm to 2.38 mm, and wherein the discrete particles are present in the heterogeneous composition in an amount of 60 wt % or greater, based on the total weight of the heterogeneous composition.
US Pat. No. 10,428,288

PROCESS FOR CONVERTING A BIOMASS INTO AT LEAST ONE BIOCHAR

1. A method for transforming a biomass into at least one biochar, comprising the following steps of:(a) providing a ground and dried biomass, said biomass containing at least 30% of a lignocellulosic biomass, by mass relative to the dry weight of the ground and dried biomass and said biomass being in the form of particles with homogeneous dimensions and having a moisture content close to 0;
(b) heating progressively this biomass at a temperature higher than 140° C. and lower than 350° C., in an oxygen-free gas stream, at a pressure comprised between 1 and 40 bar until exothermic phenomenon takes off;
(c) allowing the exothermic reaction to proceed by maintaining the temperature in the 300-700° C. range and the pressure in the 1-40 bar range;
(d) cooling the biomass derived from step (c), at a temperature of at most 100° C., in an oxygen-free gas stream; and
(e) collecting the biochar,
said method being implemented without any supply of external inert gas.
US Pat. No. 10,428,290

DE-ICING LUBRICANT COMPOSITION

1. A de-icing lubricant composition, comprising:a. isopropyl alcohol comprising 60-90% of the composition by weight; and
b. mineral oil.
US Pat. No. 10,426,757

COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL AND/OR NON-STEM PROGENITOR CELL FUNCTION

Whitehead Institute for B...

1. A method of stimulating the proliferation and/or self-renewal of one or more intestinal stem cells in mammalian intestinal tissue in a subject, the method comprising contacting a population of cells in the mammalian intestinal tissue with an effective amount of a compound that increases the level and/or activity of peroxisome proliferator activated receptor delta (PPAR-?) or a PPAR-? target protein, thereby stimulating the proliferation and/or self-renewal of one or more intestinal stem cells, wherein the contacting of the population of cells with the effective amount of the compound occurs in a subject suffering a disease characterized by intestinal stem cells that require increased proliferation and/or self-renewal, wherein the compound comprises a PPAR-? agonist or a PPAR-? target protein agonist selected from the group consisting of a CPT1A agonist, a HMGCS2 agonist, and a FABP1 agonist.
US Pat. No. 10,428,037

METHOD FOR THE SYNTHESIS AND PURIFICATION OF ETHERS

The United States of Amer...

1. A method of purifying an ether, comprising:reacting a mixture comprising tetrahydrofurfuryl alcohol, about one-half equivalent of low work function element;
adding about one-half equivalent of a halide;
adding about one-half equivalent of low work function element and one-half equivalent of halide and reacting;
adding an excess amount of low work function element until unreacted low work function element is detected; and,
fractionally distilling said mixture to obtain the purified ether wherein said low work function element is an elemental metal or a metal hydride which has a ? of less than about 3.0 eV.
US Pat. No. 10,428,293

ENHANCED EXTREME PRESSURE LUBRICANT FORMULATIONS

Dow Global Technologies L...

1. A lubricant formulation comprising:a. at least 50 weight-percent of a hydrocarbon base oil;
b. five weight-percent or more and less than 50 weight-percent of an oil soluble polyalkylene glycol selected from a group consisting of monol, diol and triol initiated 1,2-butylene oxide homopolymers and monol initiated copolymers of 1,2-butylene oxide and propylene oxide; and
c. 0.1 weight-percent or more and five weight-percent or less of a sulfurized olefin, where weight-percent is based on total lubricant formulation weight.
US Pat. No. 10,426,759

USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS

NOVARTIS AG, Basel (CH)

1. A compound which is a citrate salt of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide.
US Pat. No. 10,428,040

PROCESSES FOR THE ISOLATION OF A CANNABINOID EXTRACT AND PRODUCT FROM CANNABIS PLANT MATERIAL

1. A process for obtaining a cannabinoid extract from Cannabis plant material comprising:a) the step of providing a dispersion of material comprising cannabinoids derived from one or more Cannabis plants in an oil;
b) the step of isolating at least a portion of said cannabinoids from said dispersion to obtain a cannabinoid extract, wherein said step of isolating comprises one or both of:
A) stripping said dispersion under reduced pressure with a gaseous stripping medium to extract at least a portion of said cannabinoids from said dispersion into said gaseous stripping medium to obtain a vapour containing cannabinoids;
condensing at least part of said vapour to form a condensate; and
recovering a cannabinoid extract from said condensate; and/or
B) mixing said dispersion with a polar solvent, and forming a two-phase system with a first phase of said dispersion and a second phase of said polar solvent, wherein at least part of the cannabinoids is extracted into the second phase: isolating at least part of the second phase from the first phase; and wherein the extraction is optionally followed by
evaporating at least part of said isolated second phase to obtain a cannabinoid containing evaporation residue.
US Pat. No. 10,428,296

UNIT DOSE FABRIC SOFTENER

Colgate-Palmolive Company...

1. A unit dose fabric conditioner comprising a fabric conditioner composition contained within a water soluble pouch, wherein the composition is liquid at 25° C. and comprises:a) a cationic fabric softening active, wherein the cationic fabric softening active is at least one active chosen from esterquat, tallow esterquat, triolyeyl esterquat, and diolyeyl esterquat;
b) at least 50% by weight of the composition of a C3-C12 polyol that is liquid at 25° C.;
c) a C9-C15 alkoxylated alcohol having an average of 3 to 8 EO per mole and which is liquid at 25° C.;
d) a dispersing polymer for dispersing the cationic fabric softening active; and
encapsulated fragrance;
wherein the alkoxylated alcohol is present in an amount of 2.6 to 7.1% by weight of the composition; and
wherein the dispersing polymer is present in an amount of 1.6 to 5.8% by weight of the composition.
US Pat. No. 10,428,043

GREEN OXIDATION CATALYTIC SYSTEM

TRUSTEES OF BOSTON UNIVER...

1. A reaction mixture comprisingan oxidation catalyst comprising a metal ion complexed with an ?-keto acid and a tridentate N,N,O-ligand;
a solvent, wherein the solvent is in contact with the oxidation catalyst; and
a substrate dissolved in the solvent, wherein the solvent and the substrate are different; and wherein the solvent is a polar or polar aprotic solvent.