US Pat. No. 10,709,360

MEDICAL DEVICE WITH INTEGRATED BIOSENSOR

BIOCREDE INC., San Diego...

1. A medical device (100) with integrated bio-sensor, comprising:a tubular body (101), the tubular body comprising a first lumen (250) and a second lumen (350) therein;
the first lumen comprising a nitric oxide donor material (201) disposed therein, wherein said nitric oxide donor material is configured to release nitric oxide gas;
the second lumen being longitudinally disposed parallel with respect to the first lumen and configured to house componentry of at least a first biosensor (300), the first biosensor having a first sensor-volume (375) associated therewith;
wherein a first nitric oxide channel (275) is disposed between the nitric oxide donor material and the first sensor-volume, the first nitric oxide channel being configured to direct a flow of the nitric oxide gas into the first sensor-volume for preventing bacterial-proliferation, coagulation, or a combination thereof,
wherein the first biosensor and the nitric oxide donor material are each disposed in a distinct lumen of the first and second lumens.

US Pat. No. 10,709,358

SIZING DEVICE, AND METHODS OF MANUFACTURE AND USE THEREOF

SOMMETRICS, INC., Vista,...

1. A sizing frame for determining the fit of a therapy device, the therapy device configured to mate to an individual at a position corresponding approximately to the anterior triangle of the neck of the individual to create an enclosed space for the administration of negative pressure upon the external neck surface of the individual, the sizing frame comprising:a mating surface configured to engage with a surface on the individual corresponding to the contact surface of the therapy device, the mating surface configured to permit visualization of the individual's skin surface from a position that will be internal to the enclosed space of the desired therapy device.

US Pat. No. 10,709,355

SYSTEMS, DEVICES, AND METHODS FOR PERFORMING ACTIVE AUSCULTATION AND DETECTING SONIC ENERGY MEASUREMENTS

Respira Labs, Inc., Moun...

1. A method of performing active auscultation comprising:directing, by a processor, a broadband acoustic signal into user's body toward a user's lung, wherein the broadband acoustic signal is a pulse that comprises a plurality of frequencies;
receiving, by the processor, an acoustic signal from the user's body, the received acoustic signal corresponding to the broadband acoustic signal;
determining, by the processor, a characteristic of the received acoustic signal, wherein the characteristic is at least one of an intensity and a frequency of the received acoustic signal; and
determining, by the processor, a volume of trapped air present in the user's lung using the determined characteristic, the trapped air being air that is trapped within discrete pockets of lung tissue of the user's lung following the user's exhalation of air from the lung.

US Pat. No. 10,709,350

BODY IMPEDANCE MEASURING DEVICE

Falko Skrabal, Graz (AT)...

1. Device for impedance measurements on segments of a human or animal body, the impedance measurements being multi-frequency impedance measurements, wherein the device comprises a current source, current changeover switches, current electrodes placeable on segments of the human or animal body, voltage changeover switches and measuring electrodes, wherein each output of the current source is connected to an input of a current changeover switch, wherein each current changeover switch has a plurality of outputs and the input of the respective current changeover switch is switchably interconnectable with one of its outputs, wherein each of the outputs of the current changeover switches is connected by an electric feed line to one of the current electrodes, wherein each voltage changeover switch has a plurality of inputs and an output and the output of the respective voltage changeover switch is switchably interconnectable with one of its inputs, wherein each of the inputs of the voltage changeover switches is connected by a signal line to one of the measuring electrodes, wherein the measuring electrodes detect voltage signals and the device determines the impedances of the segments of the human or animal body from the current supplied by the current source and the detected voltage signals, wherein switching devices are incorporated into each of the electric feed lines at the current electrodes, with which switching devices each of the current electrodes may be connected to or disconnected from its electric feed line, wherein the device is configured to always open up only one measuring section via the voltage changeover switches and respectively connect only two current electrodes to the current source by switching the current changeover switches and the switching devices, while all other current electrodes are disconnected from their electric feed lines by switching the switching devices, and to disconnect the electric feed lines from the current source by switching the current changeover switches.

US Pat. No. 10,709,342

SYSTEM AND METHOD FOR SPATIAL CARDIOVASCULAR MONITORING

1. A method of measuring arterial and venous blood pulse waveforms (BPWs) of a subject utilizing spatially selective lighting changes, comprising:providing a plurality of virtual sensors positioned to cover a desired field-of-view of the subject, each virtual sensor adapted to detect and measure intensity of arterial and venous BPW signals from an area of a subject's body and provide arterial and venous BPW signal outputs using spatially coded lighting and sensing;
processing the arterial and venous BPW signal outputs of the plurality of virtual sensors to compare the arterial and venous BPWs at multiple areas of the subject's body in the time and frequency domain to perform spatial perfusion analysis; and
displaying at least one arterial and venous pulsatility perfusion aggregate output utilizing different colors to show the intensity of arterial and venous BPWs.

US Pat. No. 10,709,333

INSTRUMENT FOR ACQUIRING CO-REGISTERED ORTHOGONAL FLUORESCENCE AND PHOTOACOUSTIC VOLUMETRIC PROJECTIONS OF TISSUE AND METHODS OF ITS USE

1. An instrument for acquiring co-registered orthogonal fluorescence and photoacoustic volumetric projections, comprising:an imaging tank filled with liquid, the liquid comprising a coupling medium selected from the group consisting of: a single chemical, mixture, solution, suspension, emulsion or gel;
an object positioning mechanism configured to position an interrogated object, or part thereof, inside the coupling medium in the tank and to rotate the interrogated object about a rotation axis relative to the tank;
an optical excitation unit fixed with respect to the tank and configured to induce both fluorescence and photoacoustic responses inside the interrogated object using the same optical excitation spectrum and the same irradiation pattern at the surface of the interrogated object, with light-emitting outputs arranged so as to illuminate two opposite sides of the interrogated object at each of a plurality of rotational positions of the interrogated object;
an array of unfocused photoacoustic transducers fixed with respect to the tank, each element of the array configured to detect photoacoustic signals generated inside the interrogated object, the array being arranged such that a plane connecting the rotation axis and a central portion of the array cuts through the interrogated object separating the two sides irradiated by the optical excitation unit;
at least one optical detector fixed with respect to the tank, configured to register planar projections of sources of fluorescence generated inside the object, and arranged opposite to the array of photoacoustic transducers with respect to the interrogated object; and,
a data acquisition unit configured to synchronize acquisition of photoacoustic data, acquisition of fluorescence data, optical excitation, and rotational position of the interrogated object;
the instrument being further configured to amplify, filter, digitize, and transfer acquired data to a peripheral system for subsequent storage, processing, or visualization.

US Pat. No. 10,709,327

THIN FILM ANALYSIS APPARATUS AND METHOD FOR A CURVED SURFACE

1. A thin film analysis apparatus, comprising:an illuminator for providing illumination light to an extended area of a sample, wherein said sample has a geometrical shape;
an imaging group to receive reflected light from said extended area of said sample;
at least one non-polarizing beamsplitter to receive said reflected light from said imaging group and split said reflected light into more than one optical branch;
at least two analyzers, one for receiving one of said more than one optical branch from said beamsplitter and analyzing a polarization state thereof, wherein each of said at least two analyzers is located between one of said at least one beamsplitter and a detector;
at least two detectors, one for receiving one of said more than one optical branch from one of said at least two analyzers to generate and record image series of a surface of said extended area of said sample, wherein one detector is aligned uniquely with one of said at least two analyzers; and
a reference phantom with known optical properties to replace said sample for calibration, wherein said reference phantom has the same or substantially similar geometrical shape as of said sample or a segment of said sample.

US Pat. No. 10,709,324

SYSTEMS AND METHODS FOR PERFORMING A SURGICAL PROCEDURE

Purdue Research Foundatio...

1. A system for performing a surgical procedure within a cavity of a living body, the system comprising:a cannula having a tubular body with at least first and second ports located at first and second ends thereof, the second end configured to be inserted into the cavity; and
at least a first tool configured to be inserted into the cannula through the first port on the first end, extend through the body of the cannula, and protrude from the second end through a second port, the first tool comprising a shaft with a working element on a distal end of the shaft, the working element comprising a base, a flexible joint directly coupled to the base, and at least a first portion coupled to the base by the flexible joint and capable of articulation relative to the base and the shaft and rotation relative to the cannula, the working element being configured to perform tasks in the cavity;
wherein the working element is produced during an additive manufacturing step so that the base, the flexible joint, and the first portion of the working element are a single integral component as a result of the base, the flexible joint, and the first portion being formed by particles fused together, the flexible joint is formed of a flexible material such that the first portion is able to articulate relative to the base, and the base and the first portion are formed of materials that are different than the flexible material of the flexible joint so that the base and the first portion are more rigid than the flexible material of the joint.

US Pat. No. 10,709,322

LARYNGOSCOPE WITH INTEGRATED AND CONTROLLABLE SUCTION

UNIVERSITY OF LOUISVILLE ...

1. A laryngoscope, the laryngoscope comprising:a handle, said handle comprising an upper internal channel formed within the handle so that the handle and the upper internal channel comprise a single structure;
a suction port configured for connection to an air source at a proximal end of the handle and formed within the handle so that the handle and the suction port comprise a single structure, said suction port defining an opening into the upper internal channel;
a middle internal channel formed within the handle so that the handle and the middle internal channel comprise a single structure, said middle internal channel configured to (a) be operatively connected to at least one port to an external surface of the handle, said operative connection providing fluid communication between the middle internal channel and the at least one port, and (b) be transverse to the upper internal channel; and
a blade formed in connection with the handle such that the handle and the blade comprise one structure, said blade comprising a first set of one or more intake ports and a second set of one or more intake ports;
wherein the laryngoscope comprises a first lower internal channel with a non-circular profile formed within the blade that defines a first air flow path that extends from the upper internal channel to the first set of one or more intake ports,
wherein the laryngoscope comprises a second lower internal channel with a non-circular profile formed within the blade that defines a second air flow path that extends from the upper internal channel to the second set of one or more intake ports,
wherein the middle internal channel is configured to be interposed and provide fluid communication between (a) the upper internal channel and (b) the first and second lower internal channels such that the upper internal channel and the first and second lower internal channels are connected to the at least one port to the external surface of the handle by the middle internal channel,
wherein the first lower internal channel, the second lower internal channel, the middle internal channel, the upper internal channel, the handle and the blade comprise a monolithic structure, and
wherein the second set of one or more intake ports is located at a distance from the first set of one or more intake ports such that the second set of one or more intake ports applies suction in a different part of a patient anatomy from the first set of one or more intake ports.

US Pat. No. 10,709,319

SYSTEM AND METHOD FOR SUB-COLUMN PARALLEL DIGITIZERS FOR HYBRID STACKED IMAGE SENSOR USING VERTICAL INTERCONNECTS

DePuy Synthes Products, I...

1. An imaging sensor comprising:a pixel array comprising a plurality of pixel columns disposed on a first substrate, wherein each of the plurality of pixel columns is divided into a plurality of pixel sub-columns;
a plurality of supporting circuits disposed on a second substrate and corresponding to each of the plurality of pixel sub-columns, wherein the plurality of supporting circuits disposed on the second substrate are each only connected to one of the plurality of pixel sub-columns; and
wherein the plurality of supporting circuits are configured to independently read and process data from a corresponding pixel sub-column, and wherein pixel sub-columns within a same pixel column are read simultaneously as part of a rolling shutter.

US Pat. No. 10,709,316

METHOD AND APPARATUS FOR A ROTATING SLEEVE FOR ENDOSCOPIC PROPULSION WITH MITIGATION OF COLONOSCOPIC PERFORATION

Eladio A. Vargas, Glenvi...

1. An endoscopic sleeve apparatus for mitigating propulsion-related epithelial tearing and tissue damage, said apparatus comprising:an elastomeric, pliable, and rotatable sleeve for encasing an elongated shaft member of an endoscope, the sleeve comprising wells or slits through a proximal end of the sleeve;
any one of a right-turn or left-turn helical threading disposed on an outer surface of the sleeve from a proximal base of the endoscope and radially extending to a distal tip of the endoscope;
a distal tip port opening configured for allowing at least one channel and/or lumen axially disposed within the elongated shaft member of the endoscope to be engaged to the distal tip port opening for release and/or capture of any agent;
a housing at the proximal end of the sleeve;
a sleeve-actuator junction seal comprising prongs on a surface of the sleeve-actuator junction seal facing the proximal end of the sleeve;
at least one motor coupled to at least one actuator gear contained within the housing, whereby said actuator gear is in operable communication to the sleeve via the sleeve-actuator junction seal;
a prong-well locking mechanism to securely attach the elastic sleeve to the sleeve actuator junction seal to avoid displacement of the sleeve from the shaft member during operation, wherein prongs disposed on the surface of the seal facing the sleeve, securely fit into complementary dimensioned wells or slits on the proximal end of the sleeve;
a finger-led control disposed on the housing and operably coupled to the motor and/or actuator gear for triggering axial rotational force; and
wherein the axial rotational force caused by the motor via the actuator gear drives axial rotation of the sleeve over the elongated shaft member of the endoscope via the sleeve-actuator junction seal, and thereby allowing for forward and reverse propulsion of the endoscope through a lumen.

US Pat. No. 10,709,304

UNIVERSAL HOSE ASSEMBLY FOR WET/DRY VACUUMS

1. A universal hose assembly for wet/dry vacuums, comprising:a belt including:
at least one loop attached thereto adapted to releasably hold accessories thereto;
wherein said belt is adapted to adjustably attach around an outer wall of a wet/dry vacuum;
an expanding hose including:
an elongated cylindrical wall including:
a proximal end;
a distal end: and
a length extending from said proximal end to said distal end;
wherein said elongated cylindrical wall forms a hollow interior volume;
an attachment portion including:
a ring portion;
wherein said ring portion is adapted to connect with a ring portion of said wet/dry vacuum; and
a connector portion;
wherein said connector portion is rotatably connected to said ring portion and extends outwardly therefrom;
wherein said ring portion and said hose connector portion form a hollow cylindrical interior volume;
wherein said proximal end of said elongated cylindrical wall is pivotally connected to said connector portion of said attachment portion; and
an expandable hose member including:
a flexible cylindrical wall including:
a proximal end;
a distal end;
an exterior surface; and
an interior surface;
wherein said flexible cylindrical wall forms a hollow interior volume; and
a helical wire;
wherein said helical wire is attached to said interior surface of said flexible cylindrical wall from said proximal end to said distal end, such that said expandable hose member is adapted to contract into a contracted configuration and be pulled into a plurality of expanded configurations to thereby adjust the length of said expandable hose member;
wherein said expandable hose member is attached to said attachment portion and extends a substantial portion of said length of said elongated cylindrical wall when in said contracted configuration, and is adapted to extend a substantial length beyond said length of said elongated cylindrical wall when in a plurality of said expanded configurations;
wherein said ring portion of said attachment portion of said expanding hose is releasably connected to said belt; and
wherein said belt is adapted to releasably and adjustably hold said expanding hose to said ring portion of said wet/dry vacuum, such that air leaving and entering said ring portion of said wet/dry vacuum passes through said expanding hose.

US Pat. No. 10,709,296

BACKSPLASH COVERING ASSEMBLY

1. A backsplash covering assembly for protecting grout in a backsplash from damage and discoloration, said assembly comprising:a countertop having a sink therein;
a wall intersecting said countertop behind said sink; and
a splash guard being positioned at an intersection between said countertop and said sink, said splash guard being comprised of a fluid impermeable material wherein said splash guard is configured to inhibit water from reaching said intersection, said splash guard being positioned behind said sink directly against said countertop and said wall wherein said splash guard is configured to protect the grout in said intersection, said splash guard being comprised of a translucent material such that said grout is visible through said splash guard, said splash guard having a first end, a second end and an outer surface extending therebetween, said splash guard being elongated between said first and second ends, said outer surface having a front side, a back side, a bottom side and a top side, said back side being oriented perpendicular to each of said top and bottom sides, said back side being positioned against said wall, said bottom side being positioned against said countertop, said front side having a curve therein extending inwardly toward an intersection between said bottom side and said back side to define a vertical portion of said front side and a horizontal portion of said front side, said vertical portion extends downwardly from said top side having said vertical portion being oriented collinear with said back side, said horizontal portion sloping downwardly toward said bottom side wherein said horizontal portion is configured to direct water to flow onto said countertop when the water is splashed onto said splash guard.

US Pat. No. 10,709,227

OBJECT MOUNTING DEVICE

1. An object mounting device, the device comprising:a base;
a planar support surface disposed on the base;
a mounting surface disposed on the base, the mounting surface opposingly positioned to the support surface, and the mounting surface comprising a curved shape that is concave curved relative to the support surface; and
wherein the base comprises a first side wall and a base wall, and wherein the mounting surface is formed into the base wall and the first side wall.

US Pat. No. 10,709,217

PERSONAL-ORNAMENT CLASP AND PERSONAL ORNAMENT USING THE SAME

MIUMA JEWELRY CO., LTD., ...

1. A personal-ornament clasp comprising:a holder having, on a first side, a holding portion where an elongated personal ornament main body can be held via an opening, wherein the holding portion has an arc-shaped curved surface, and the holder defines a U-shaped cross section;
a closing member pivotally attached to the holder via an attaching portion on a second end of the holder, wherein the closing member defines a second U-shaped cross section and has a curved upper surface;
a soft member attached to the closing member, wherein the soft member is formed in a flat shape, and is fitted in an interior space defined by the closing member, and wherein a first end of the soft member projects beyond an open end of the first end of the closing member for gripping the personal ornament main body, and the first end of the soft member defines a convex arc portion; and
a spring mounted to the attaching portion and accommodated inside the holder, the spring having a first end piercing the soft member so as to bias the closing member and the soft member toward a closed position,
wherein, in the closed position of the closing member, a first end portion of the curved upper surface of the closing member comes into contact with the holding portion and a grip space for gripping the personal ornament main body is secured between the convex arc portion of the soft member and an open end of the holding portion,
wherein the soft member is made of silicone or rubber having a friction resistance, and
wherein the closing member is rotatable about the attaching portion due to the resilient force of the spring such that any part of the personal ornament main body can be held between the convex arc portion and the holder portion due to the friction resistance of the convex arc portion.

US Pat. No. 10,709,202

METHOD FOR MANUFACTURING SHOE

In Kwon Kang, Busan (KR)...

1. A method for manufacturing a shoe, the method comprising:putting unvulcanized rubber into an outsole frame formed in a first-stage mold;
applying predetermined heat and pressure to the unvulcanized rubber in the outsole frame;
preparing a first film by applying a pretreatment film to one surface of a first release film or first paper to a predetermined thickness and positioning the first film such that the pretreatment film borders a top of the first-stage mold and a top of the unvulcanized rubber in the outsole frame;
performing vulcanization on the unvulcanized rubber in the outsole frame;
preparing an outsole of which a top is processed with the pretreatment film by removing the first release film or first paper from the first film;
preparing a second-stage mold having a midsole frame penetrated vertically and positioning the second-stage mold on the first-stage mold such that the midsole frame is on a top of the outsole frame;
positioning a first reactive adhesive film on top of the second-stage mold;
tightly applying the first reactive adhesive film to an inner surface of the midsole frame by heating the first reactive adhesive film and creating a vacuum in the midsole frame;
preparing a third-stage mold having a fixed frame penetrated vertically and positioning an upper part inside the fixed frame;
positioning a second reactive adhesive film on a bottom of the third-stage mold such that the second reactive adhesive film is positioned on a bottom of the upper part;
tightly applying the second reactive adhesive film to the bottom of the upper part by heating the second reactive adhesive film and creating a vacuum between the bottoms of the upper part and the third-stage mold and the second reactive adhesive film;
injecting liquid foam into the midsole frame coated with the first reactive adhesive film;
putting the third-stage mold on the second-stage mold such that the bottom of the upper part coated with the second reactive adhesive film is positioned on the midsole frame injected with the liquid foam; and
forming a midsole between the outsole and the upper part by performing a foam process on the liquid foam.

US Pat. No. 10,709,179

PROTECTIVE APPARATUS HAVING AN IMPACT ATTENUATION COMPONENT

NIKE, Inc., Beaverton, O...

1. A protective apparatus comprising:a first shin guard and a second shin guard, wherein the first shin guard is a mirror image of the second shin guard, and wherein each of the first shin guard and the second shin guard includes an impact shell and an impact attenuating surface;
the impact shell having an anterior surface, an opposite posterior surface, a medial edge, an opposite lateral edge, a superior edge, and an opposite inferior edge; and
the impact attenuating structure being less rigid than the impact shell and including an anterior surface adhered to the posterior surface of the impact shell, the impact attenuating structure including a plurality of grooves positioned in a posterior surface of the impact attenuating structure,
wherein the impact attenuating structure includes a medial edge, a lateral edge, a superior edge, an inferior edge, and a midline spaced evenly between the medial edge and the lateral edge;
wherein a first groove and a second groove in the plurality of grooves extend from the superior edge of the impact attenuating structure to the inferior edge of the impact attenuating structure;
wherein the first groove is positioned on a medial side between the midline and the medial edge, and the second groove is positioned on a lateral side between the midline and the lateral edge;
wherein the first groove positioned closer to the medial edge includes a shallower groove depth than the second groove, such that a first thickness of impact attenuating structure between the first groove and the anterior surface of the impact attenuating structure is larger than a second thickness of impact attenuating structure between the second groove and the anterior surface of the impact attenuating structure; and
wherein a larger distribution of the impact attenuating structure is on the medial side of the impact attenuating structure than the lateral side of the impact attenuating structure.

US Pat. No. 10,709,166

METHOD FOR TREATING TOBACCO PLANTS WITH ENZYMES

R.J. Reynolds Tobacco Com...

1. A method of modifying the content of one or more compounds, comprising contacting an unharvested tobacco plant or portion thereof with one or more enzymes,wherein the one or more enzymes are applied in liquid form or in dry form in an amount sufficient to change the amount of the one or more compounds in a tobacco material derived from the tobacco plant or portion thereof,
wherein the one or more enzymes comprise a polyphenol oxidase, and
wherein the one or more compounds comprise smoke toxicants or smoke toxicant precursors.

US Pat. No. 10,709,161

ROTARY SCREW BLANCHER

Lyco Manufacturing, Inc.,...

1. A food processing apparatus comprising:a compartment having an inlet end for receiving food product and an outlet end for discharging food product;
a screen mounted within the compartment, the screen including a screen wall having a length, a circumferential first end and an opposite, circumferential second end, the first end and the second end defining therebetween a circumferentially-extending open portion of the screen, the open portion extending along at least a portion of the length of the screen wall, the screen being oriented relative to an auger during a food processing operation in a first orientation, in which a sidewall portion of the screen supports the food product and the open portion opens at least partially upwardly in a first direction, a screen position being adjustable to a second orientation relative to the auger, in which the screen is oriented such that the sidewall portion is accessible for cleaning; and
an auger mounted such that at least a portion of the auger is within the screen, a portion of the auger being accessible through the open portion of the screen, the auger being rotatable about an axis and for advancing food product within the compartment from the inlet end toward the outlet end.

US Pat. No. 10,709,112

PET WASTE COLLECTING DEVICE

1. A system for pet waste collecting, comprising:a. a telescopic pet waste assembly including a shaft body being telescopic and having a proximal end and distal end, said telescopic pet waste assembly further including a light at said distal end of said shaft body and a button located at said proximal end adapted to activate and deactivate said light upon pressing thereof said button;
b. a storage compartment mounted to said shaft body, said storage compartment includes a storage compartment lid mounted thereon, said storage compartment adapted to receive and hold bags therein;
c. a dispensing assembly including a dispensing body being hollow adapted to receive and hold granular material therein, said dispensing body having a filling lid hingedly mounted at a dispenser proximal end of said dispensing body and a dispensing lid hingedly mounted at a dispenser distal end of said dispensing body, said dispensing body further including a viewing window adapted to allow viewing of amounts of said granular materials stored therein said dispensing body;
d. a scooping assembly having a scooper, said scooper having a first claw and a second claw; and
e. a handle assembly including a handle body having a top portion and an opening therebetween, said handle assembly further including a finger grip mounted therebetween said opening of said handle body, said finger grip including grips adapted to receive the fingers of a user and a smooth top surface, said handle assembly having a rod mounted to said finger grip, said rod extending from said finger grip on one end therethrough telescopic shaft and mounted to said scooping assembly on an opposite end, said finger grip and said rod adapted to open and close said scooper, said scooper is opened upon said finger grip, more specifically said smooth top surface, and said rod being pulled towards said top portion of said handle body.

US Pat. No. 10,709,108

AUTOMATED SCENT TRAINING

Partrick L. Nolan, Smith...

1. An automated scent training wheel for training animals to detect and respond to target scents, comprising:a rotatable carousel;
a plurality of elongated support arms attached to and radially projecting outward from the rotatable carousel;
a plurality of ring-shaped sleeve members each attached to a distal end of one of the support arms, wherein the sleeve members each have a cylindrical wall defining an open ended cavity extending in a horizontal direction;
a plurality of scent receptacles each detachably coupled to one of the plurality of ring-shaped sleeves, wherein the scent receptacles are each configured to hold scent source material therein; and
a plurality of sensing systems each disposed at one of the plurality of scent receptacles, wherein each sensing system is configured to automatically detect investigation of the associated scent receptacle by an animal.

US Pat. No. 10,709,072

STACKABLE SELF-WATERING PLANTER WITH REMOVABLE RISER

1. A stack of stackable planters, comprising:a first planter pot and a second planter pot, wherein each of the first planter pot and second planter pot are configured to be nestable with other matching planter pots, and include:
a base;
at least one planter sidewall formed on the base and extending upwards towards a rim that is larger in area than the base;
at least one hollow support pillar formed on the base and extending substantially vertically upwards with a drain opening at the top of each of the at least one hollow support pillars in communication with an exterior side of the base;
a first removable riser and a second removable riser, wherein each removable riser is configured to be nestable with other matching removable risers, and include:
a plate having a bottom side configured to be supported only by an interior of the at least one planter sidewall above the base by an interference fit, and a top side of the plate having a same area as the base; and
at least one aperture configured to accept a corresponding hollow support pillar;
wherein, in an operation mode, the first removable riser is inserted with the top side facing up into the first stackable planter with the first removable riser being supported by the interference fit between a perimeter of the bottom side and an interior side of the planter sidewall, and the second removable riser is inserted with the top side facing up into the second stackable planter with the second removable riser being supported by the interference fit between a perimeter of the bottom side and an interior side of the planter sidewall; and
wherein, in a nested mode, the first stackable planter, the second stackable planter, the first removable riser and the second removable riser are all nested together to form a single planter stack,
wherein with the first and second removable risers each in the nested mode within the first and the second planters, respectively, the first planter is inserted into the second planter in a nested fashion, wherein the support pillar of the second planter maintains a clearance between the base of the first planter and the second removable riser.

US Pat. No. 10,709,060

LAWN CARE VEHICLE WITH ON BOARD BATTERY CHARGING

HUSQVARNA AB, Huskvarna ...

1. A riding lawn care vehicle comprising:a power unit;
a working element configured to perform a work function;
a working element driver providing operable coupling between the power unit and the working element, the working element driver being configured to drive the working element responsive to operation of the power unit; and
an external battery charger operably coupled to, and powered by, the working element driver, the external battery charger being configured to charge an external battery of a device other than the riding lawn care vehicle;
wherein the external battery charger comprises an enclosure with a plurality of electrode plates disposed on an internal base of the enclosure, the electrode plates being configured to mate with battery electrodes of the external battery.
US Pat. No. 10,711,113

POLYSACCHARIDE ADHESIVE

1. A method comprising:obtaining a polysaccharide adhesive comprising cold water-soluble and/or cold water-swellable, completely lysed, covalently cross-linked starch as a binding agent in combination with a foaming agent further defined as comprising at least one anionic, cationic, amphoteric, or nonionic surfactant; and
using the polysaccharide adhesive to prepare an adhesive foam.
US Pat. No. 10,711,371

LITHIUM NIOBATE SINGLE CRYSTAL SUBSTRATE AND METHOD OF PRODUCING THE SAME

SUMITOMO METAL MINING CO....

1. A method of producing a lithium niobate single crystal substrate by using a lithium niobate single crystal grown by the Czochralski process, whereina lithium niobate single crystal having a Fe concentration of 50 mass ppm or more and 1000 mass ppm or less in the single crystal and processed into a form of a substrate is buried in an Al powder or a mixed powder of Al and Al2O3 and heat-treated at a temperature of 450° C. or more and less than 500° C., to produce a lithium niobate single crystal substrate having a volume resistivity controlled to be within a range of 1×108 ?·cm or more to 1×1010 ?·cm or less, and
the variation (?/Ave) in the volume resistivity in the plane of the lithium niobate single crystal substrate is less than 3%, wherein
Ave is an average value of volume resistivities measured at one point in a center portion and four points on an outer peripheral portion, five points in a surface in total, of the lithium niobate single crystal substrate, and ? is a standard deviation of the volume resistivities, and the volume resistivities are values measured by a three-terminal method according to HS K-6911, and wherein
an arithmetic average roughness Ra of a surface of the lithium niobate single crystal processed into the form of the substrate is 0.2 ?m or more and 0.4 ?m or less.
US Pat. No. 10,711,127

CHLORINE-CONTAINING POLYMER COMPOSITION COMPRISING A CHLORINE-CONTAINING POLYMER AND A WAX COMPRISING A FRACTION CONSISTING OF OXIDIZED HYDROCARBONS AND A FRACTION CONSISTING OF NON-OXIDIZED HYDROCARBONS, METHOD OF PROCESSING THE POLYMER COMPOSITION AND T

Sasol South Africa (Pty) ...

1. A chlorine-containing polymer composition comprising:a chlorine-containing polymer; and
a wax comprising
a fraction consisting of oxidized hydrocarbons; and
a fraction consisting of non-oxidized hydrocarbons, wherein both fractions are Fischer-Tropsch waxes and both fractions have
an average number of carbon atoms (number average) per molecule between 40 to 100 carbon atoms; and
an amount of molecules in which the carbon chain is linear of more than 75 wt.-%.
US Pat. No. 10,709,080

MAIZE INBRED PH48RS

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH48RS, representative seed of the variety having been deposited under ATCC accession number PTA-126645.
US Pat. No. 10,711,131

HIGH-STRENGTH RUBBER COMPOSITION COMPRISING AN AROMATIC POLYPHENOL DERIVATIVE

Compagnie Generale Des Et...

1. A rubber composition comprising: at least one elastomer and at least one phenol-aldehyde resin based:on at least one derivative of an aromatic polyphenol comprising at least one aromatic ring bearing three —O—Z groups in the meta position relative to one another, the two positions ortho to at least one of the —O—Z groups being unsubstituted, Z being other than hydrogen, and
on at least one aldehyde.
US Pat. No. 10,709,082

MAIZE INBRED PH40W4

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH40W4, representative seed of the variety having been deposited under NCMA accession number 202004018.
US Pat. No. 10,714,208

COMPUTER SYSTEMS FOR TREATING DISEASES

BIOTEMPUS PTY LTD, North...

1. A non-transitory computer-readable information storage medium having stored thereon instructions, that if executed by one or more processors, perform a method comprising:i) obtaining from a first memory measurements of an immune system marker in samples from a subject having a disease characterized by cycling immune system markers;
ii) obtaining from a second memory a model of cycling of the immune system marker;
iii) fitting the measurements to the model;
iv) obtaining a best-fit curve of the measurements to the model to estimate a periodicity of the cycling of the immune system marker;
v) projecting the obtained best-fit curve into the future; and
vi) outputting a preferred time in the future, based on the projected best-fit curve, to administer a therapy to treat the disease.
US Pat. No. 10,709,083

MAIZE INBRED PH48J7

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH48J7, representative seed of the variety having been deposited under NCMA accession number 202004012.
US Pat. No. 10,714,209

METHOD AND SYSTEM FOR SPECTRAL DATA ANALYSIS

Protein Dynamic Solutions...

1. A method for processing data representing a characteristic of proteins, peptides, and/or peptoids, the method comprising:applying a controlled perturbation to the proteins, peptides, and/or peptoids in a solution;
sequentially acquiring spectral images of the proteins, peptides, and/or peptoids in the solution using a quantum cascade laser microscope without the use of exogenous probes or additives, the sequentially acquired spectral images capturing induced changes in spectral intensities as a function of the applied perturbation;
identifying and selecting, in at least one of the acquired spectral images, a region of interest with respect to the applied perturbation;
selecting and analyzing spectral data including data for side chains of amino acids in the proteins, peptides and/or peptoids in the solution for the region of interest in a plurality of the sequentially acquired spectral images, wherein analyzing the spectral data includes analyzing side chain modes of the proteins, peptides, and/or peptoids as internal probes;
applying two-dimensional co-distribution (2DCDS) analysis to generate an asynchronous co-distribution plot for the proteins, peptides, and/or peptoids; and
identifying in the asynchronous co-distribution plot at least one cross peak associated with aggregation of the proteins, peptides, and/or peptoids.
US Pat. No. 10,709,084

MAIZE INBRED PH2T8W

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH2T8W, representative seed of the variety having been deposited under NCMA accession number No. 202004006.
US Pat. No. 10,711,135

HIGH TEMPERATURE RESISTANT, TWO COMPONENT, LOW VISCOSITY SILICONE COMPOSITION

1. A two part curable composition, wherein:the first part comprises organosiloxane polymer, water, and 0% to 1% hexamethyldisilazane (HMDS);
the second part comprises crosslinker; aminosilane adhesion promoter, catalyst, and 0% to 12% hexamethyldisilazane (HMDS); and
either or both parts can optionally further comprise one or more of vinyltrimethoxysilane; plasticizer; colorant, filler and additives; wherein at least one of the parts contains at least 0.1 wt. % of hexamethyldisilazane (HMDS) and the mixed composition has a viscosity at room temperature less than 200,000 cP.
US Pat. No. 10,713,700

REPLACEMENT FOOTWEAR, PROCESS FOR ADDITION OF FOOTWEAR TO A USER'S FOOTWEAR COLLECTION, FOOTWEAR VENDING MACHINE, FOOTWEAR DISTRIBUTION PROCESS AND FOOTWEAR REPLACEMENT PROCESS

Grendene S.A., Sobral (B...

1. A shoe vending machine for selling an individual shoe to a user, comprising:a) a partitioned storage means, comprising at least one shoe storage partition;
b) a selection interface;
c) a payment means;
d) a delivery means for individually supplying a shoe stored in the partioned storage means to the user; and
e) a processing modulus comprising a means for communication with the internet, the processing modulus actuating the partitioned storage means, the selection interface, the payment means, and the delivery means;
wherein:
each of the at least one shoe storage partition having at least one shoe having at least one feature in common with at least one feature of at least one shoe of a user shoes collection;
the shoes stored in the partitioned storage means each having a geometry that adapts to both of the user's left foot and right foot;
the selection interface provides available shoe options for the shoes stored in the partitioned storage means, according to any physical feature of the shoe, wherein the selection interface comprises at least one of a shoe models catalog for pre-sale of a shoe ordered by the user, an interactive menu for customization of a shoe by the user, a means for communication with the user to inform the user that a requested shoe is ready for pickup, and a means to identify the shoes available in the partitioned storage means, wherein the means to identify the shoes available automatically issues a restock order from a predetermined minimum shoe stock limit in the partitioned storage means; and
the physical feature is selected from the group consisting of: size; shape; decorativeness; functionality; and material.
US Pat. No. 10,709,089

INTROGRESSION OF TWO YIELD QTLS IN CUCUMIS SATIVUS PLANTS

NUNHEMS B.V., Nunhem (NL...

1. A cultivated Cucumis sativus var. sativus plant, or plant cell, tissue, plant part or seed thereof, comprising an introgression fragment on chromosome 2 in homozygous or heterozygous form, wherein said introgression fragment is the fragment as found on chromosome 2 in seeds of which a representative sample has been deposited under accession number NCIMB 42545, wherein said introgression fragment comprises a Quantitative Trait Locus referred to as QTL2.1, which confers an increase in cucumber fruit yield, wherein said introgression fragment on chromosome 2 comprises at least one of the following markers:a) the CC or CT genotype for the Single Nucleotide Polymorphism marker SNP 01 at nucleotide 75 of SEQ ID NO: 1;
b) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 02 at nucleotide 75 of SEQ ID NO: 2;
c) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 03 at nucleotide 75 of SEQ ID NO: 3;
d) the TT or TC genotype for the Single Nucleotide Polymorphism marker SNP 04 at nucleotide 75 of SEQ ID NO: 4;
e) the TT or TC genotype for the Single Nucleotide Polymorphism marker SNP 05 at nucleotide 75 of SEQ ID NO: 5;
f) the CC or CT genotype for the Single Nucleotide Polymorphism marker SNP 06 at nucleotide 75 of SEQ ID NO: 6;
g) the CC or CT genotype for the Single Nucleotide Polymorphism marker SNP 07 at nucleotide 75 of SEQ ID NO: 7;
h) the AA or AG genotype for the Single Nucleotide Polymorphism marker SNP 08 at nucleotide 75 of SEQ ID NO: 8;
i) the TT or TG genotype for the Single Nucleotide Polymorphism marker SNP 09 at nucleotide 75 of SEQ ID NO: 9;
j) the TT or TG genotype for the Single Nucleotide Polymorphism marker SNP 10 at nucleotide 75 of SEQ ID NO: 10;
k) the GG or AG genotype for the Single Nucleotide Polymorphism marker SNP 11 at nucleotide 75 of SEQ ID NO: 11;
l) the GG or GT genotype for the Single Nucleotide Polymorphism marker SNP 12 at nucleotide 75 of SEQ ID NO: 12;
m) the CC or CA genotype for the Single Nucleotide Polymorphism marker SNP 13 at nucleotide 75 of SEQ ID NO: 13;
n) the AA or AG genotype for the Single Nucleotide Polymorphism marker SNP 14 at nucleotide 75 of SEQ ID NO: 14;
o) the CC or CT genotype for the Single Nucleotide Polymorphism marker SNP 15 at nucleotide 75 of SEQ ID NO: 15;
p) the AA or AC genotype for the Single Nucleotide Polymorphism marker SNP 16 at nucleotide 75 of SEQ ID NO: 16;
q) the TT or TC genotype for the Single Nucleotide Polymorphism marker SNP 17 at nucleotide 75 of SEQ ID NO: 17;
r) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 18 at nucleotide 75 of SEQ ID NO: 18;
s) the AA or AG genotype for the Single Nucleotide Polymorphism marker SNP 19 at nucleotide 75 of SEQ ID NO: 19;
t) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 20 at nucleotide 75 of SEQ ID NO: 20;
u) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 21 at nucleotide 75 of SEQ ID NO: 21;
v) the GG or GT genotype for the Single Nucleotide Polymorphism marker SNP 22 at nucleotide 75 of SEQ ID NO: 22;
w) the TT or TG genotype for the Single Nucleotide Polymorphism marker SNP 23 at nucleotide 75 of SEQ ID NO: 23;
x) the GG or GT genotype for the Single Nucleotide Polymorphism marker SNP 24 at nucleotide 75 of SEQ ID NO: 24;
y) the GG or GA genotype for the Single Nucleotide Polymorphism marker SNP 25 at nucleotide 75 of SEQ ID NO: 25; or
z) the CC or CA genotype for the Single Nucleotide Polymorphism marker SNP 26 at nucleotide 251 of SEQ ID NO: 26.
US Pat. No. 10,714,224

METHOD OF PREPARING OF IRRADIATION TARGETS FOR RADIOISOTOPE PRODUCTION AND IRRADIATION TARGET

FRAMATOME GMBH, Erlangen...

1. A method for preparing irradiation targets for radioisotope production in instrumentation tubes of a nuclear power reactor, the method comprising the steps of:providing a powder consisting of an oxide of a rare earth metal having a purity of greater than 99% and, optionally, an organic binder;
agglomerating the powder and the optional organic binder in a rotating drum or on a rotating disc so as to pelletize the powder and the optional organic binder and to form the powder and the optional organic binder into a substantially spherical green body having a diameter of from between 1 to 10 mm, and
sintering the green body in solid phase at a temperature of at least 70 percent of a solidus temperature of the rare earth metal oxide powder and for a time sufficient to form a substantially spherical sintered rare earth metal oxide target having a sintered density of at least 80 percent of the theoretical density.
US Pat. No. 10,714,751

NEGATIVE ELECTRODE FOR LITHIUM ION SECONDARY BATTERY AND LITHIUM ION SECONDARY BATTERY

Envision AESC Energy Devi...

1. A negative electrode for a lithium ion secondary battery, comprising a current collector and a negative electrode active material layer on the current collector,wherein the negative electrode active material layer comprises:
a first composite particle comprising a first graphite core particle and a first non-graphite-based carbon material coating a surface thereof; and
a second composite particle comprising a second graphite core particle and a second non-graphite-based carbon material coating a surface thereof, and wherein
an average particle diameter dA (D50) of the first composite particles is 5 to 30 ?m;
an average particle diameter dB (D50) of the second composite particles is 2 to 25 ?m, and is smaller than the average particle diameter dA of the first composite particles;
a mixing ratio of the first composite particle A and the second composite particle B is 50:50 to 95:5 in mass ratio (A:B); and
a density of the negative electrode active material layer is 1.4 to 1.7 g/cm3, and
wherein, provided that D10, D50 and D95 represent particle diameters at a cumulation of 10%, 50% and 95% from the fine particle size side in a cumulative particle size distribution, respectively,
a ratio D50/D10 of D50 and D10 of the first composite particles is 1.5 or lower;
a ratio D95/D10 of D95 and D10 of the first composite particles is 1.7 or higher;
a ratio D50/D10 of D50 and D10 of the second composite particles is 1.3 or lower; and
a ratio D95/D10 of D95 and D10 of the second composite particles is lower than 1.7.
US Pat. No. 10,711,167

ADHESIVE COMPOSITION

Strongbond B.V., Dinxper...

1. Aqueous adhesive composition comprising(a1) 40-97 wt. % of a dispersion, comprising one or more of polychloroprene dispersion, polyurethane dispersion, natural rubber dispersion, styrene-butadiene-styrene copolymer dispersion, nitrile-butadiene rubber, polyvinyl butyral dispersion, styrene-butadiene rubber dispersion, and combinations thereof, the dispersion comprising 30-80 wt. % solids,
(a2) 2-50 wt. % plasticizer, wherein the plasticizer is selected from mono-esters from benzoic acid and a C4-C16 alcohol, and combinations thereof,
(a3) 0.0-5 wt. % surfactant,
(a8) 0.1-40 wt. % pH stabilizer,
(a9) 0.1-2 wt. % of one or more of a fungicide, a bactericide, and an algaecide, and preferably at least one of
(a5) 0.1-40 wt. % of a resin dispersion, the resin dispersion comprising 30-70 wt. % solids,
(a6) 0.1-8 wt. % of an acid binder,
(a7) 0.1-15 wt. % thickener,
(a10) 0.001-1 wt. % defoamer,
(a11) 0.001-1 wt. % emulsifier,
(a12) 0.001-1 wt. % wetting agent
(a13) 0.1-2 wt. % of a colorant, and
(a14) 0.1-3 wt. % of anti-degradant,
(a4) the remainder being water,
wherein all parts are calculated based on the total weight of the composition.
US Pat. No. 10,711,170

TWO-COMPONENT TYPE URETHANE-BASED ADHESIVE COMPOSITION FOR AN AUTOMOBILE

Sunstar Engineering Inc.,...

1. A two-component type urethane-based adhesive composition for an automobile comprising:(1) a first component comprising an isocyanate group-terminated polyether polyol compound, and
(2) a second component comprising a polyol compound and a curing catalyst,wherein the polyol compound in the second component comprises a polyol having an average hydroxyl value of 40 to 100 [mgKOH/g], and comprises 2 to 50% by mass of a multifunctional polyol having a number of hydroxyl groups from 2.3 to 10 and a hydroxyl value of 160 to 550 [mgKOH/g], based on the mass of the polyol compound,wherein a cured product formed from the first component alone has an elastic modulus of 5 to 20 MPa and an elongation of 300 to 850%,
and wherein a cured product formed from a mixture of the first and second components at a mixing ratio of the first component to the second component of 100:10 has an elastic modulus of 3 to 20 MPa and an elongation of 300 to 650%.
US Pat. No. 10,709,644

ORAL CARE PRODUCTS AND METHODS OF USE AND MANUFACTURE THEROF

Colgate-Palmolive Company...

1. A lubricating dual-phase mouthwash for the treatment or alleviation of dry mouth comprising:a hydrophilic phase;
a hydrophobic phase comprising at least two oils, wherein the oils comprise coconut oil in an amount of from 0.1%-1% by weight of the composition and mineral oil in an amount of from 5%-15% by weight of the composition, wherein the coconut oil is dispersed in the mineral oil, wherein the hydrophobic phase is from 5% to 20% of the composition by volume;
a hydrotrope component, wherein the hydrotrope component comprises glycerin and sorbitol;
wherein the mouthwash is prepared by a process comprising the steps of:
a) dispersing coconut oil in a hydrophobic composition comprising an oil to form a mixture; and
b) combining the mixture with the hydrophilic phase and the hydrotrope component, and
wherein the composition delivers a lubricating effect to the oral cavity.
US Pat. No. 10,709,646

ORAL CARE WHITENING COMPOSITIONS

Colgate-Palmolive Company...

1. An oral care whitening composition comprising a non-aqueous phase comprising:a peroxysulfate whitening agent comprising potassium peroxymonosulfate;
a hydrophobic base comprising a silicone adhesive and a silicone polymer present in a weight ratio ranging from about 70:30 to about 50:50, wherein the hydrophobic base is present at a concentration of 20 to 80%, by weight of the composition; and
at least one hydrophilic polymer comprising:a block copolymer of ethylene oxide and propylene oxide, wherein the ethylene oxide constituent comprises from 65% to 75% by weight of the copolymer;a mixture of soluble linear polymers and insoluble cross-linked polymers, selected from a mixture of linear polyvinylpolypyrrolidone (PVP) and cross-linked PVP; andwherein the non-aqueous phase is substantially anhydrous.
US Pat. No. 10,709,654

SYNERGISTIC PHOTOPROTECTIVE COMPOSITIONS

EDGEWELL PERSONAL CARE BR...

1. A photoprotective composition, comprising:at least one photoactive agent present in an amount of about 0.1 to about 40 wt. %, based on a total weight of the photoprotective composition;
a synergistic combination of polymers present in an amount of about 0.1 to about 15 wt. %, based on a total weight of the photoprotective composition comprising:
0.1 to 5 wt. % of an alkyl-dimethicone having a hydrophilic group, an alkyl-PPG dimethicone, an alkyl-PEG dimethicone, or combinations thereof;
0.1 to 5 wt. % of a polymer with ester linkages comprising polyglyceryl stearate/isostearate dilinoleate crosspolymer in semi-solid form, polyglyceryl stearate/isostearate dilinoleate crosspolymer in liquid form, polyglyceryl stearate/isostearate dilinoleate crosspolymer in solid form or combinations thereof; and
0.1 to 5 wt. % of phenylisopropyl dimethicone; and
0.1 to 5 wt. % of an abietic acid ester,wherein said photoprotective composition is an anhydrous, single phase, homogenous composition that forms a substantially complete film on a dry or wet substrate, andwherein said synergistic combination of polymers increases a UVR absorbance of the photoprotective composition in comparison with a photoprotective composition without said synergistic combination of polymers.
US Pat. No. 10,711,201

METHOD FOR CONVERTING ALGAL BIOMASS INTO A GAS OR INTO BIOCRUDE BY HYDROTHERMAL GASIFICATION OR HYDROTHERMAL LIQUEFACTION, RESPECTIVELY

1. A method for converting algal biomass into a gas or biocrude with a view to producing a fuel, a motor fuel, or a liquid fuel, or some other synthetic product, comprising:(a) gasification or hydrothermal liquefaction of an algal biomass in at least one first reactor;
(b) separation between respectively the gas or biocrude produced and the aqueous effluents and the CO2 produced at the outlet of the first reactor;
(c) recovery of the aqueous effluents; and
(d) oxidation of the aqueous effluents in at least one second reactor;
wherein step (d) is oxidation by a wet process or a hydrothermal oxidation (HTO) in supercritical conditions.
US Pat. No. 10,709,672

POLYPHENOL-CONTAINING SOLID COMPOSITION

SAN-EI GEN F.F.I., INC., ...

1. A solid composition comprising(1) an amorphous poorly water-soluble polyphenol,
(2) a hydrophilic polymer, and
(3) at least one nonionic surfactant selected from the group consisting of polyglycerol fatty acid esters and sucrose fatty acid esters.
US Pat. No. 10,711,244

MAMMALIAN NEURAL PLATE BORDER STEM CELLS CAPABLE OF FORMING NEURAL TUBE AND NEURAL CREST CELL LINEAGES INCLUDING CENTRAL AND PERIPHERAL NEURONS

1. A method for producing mammalian neural plate border stem cells (NPBSCs), comprising:(a) differentiating mammalian pluripotent stem cells by
(a-i) culturing mammalian pluripotent stem cells in pluripotent stem cell medium for about 24 to about 96 hours, wherein the pluripotent stem cell medium comprises:
(i) an inhibitor of the activin/TGF-? signalling pathway;
(ii) an inhibitor of the BMP signalling pathway;
(iii) 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; and
(iv) an activator of the Hedgehog signalling pathway; subsequently
(a-ii) culturing the cells obtained in step (a-i) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises:
(i) an inhibitor of the activin/TGF-? signalling pathway;
(ii) an inhibitor of the BMP signalling pathway;
(iii) 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; and
(iv) an activator of the Hedgehog signalling pathway; subsequently
(a-iii) culturing the cells obtained in step (a-ii) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises:
(i) 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile;
(ii) an activator of the Hedgehog signalling pathway; and
(iii) an inhibitor of oxidation;
(b) plating the obtained differentiated mammalian pluripotent stem cells in NPBSCs expansion medium, wherein the NPBSCs expansion medium comprises
(i) 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile;
(ii) an activator of the Hedgehog signalling pathway; and
(iii) an inhibitor of oxidation;
and expanding the cells in the NPBSCs expansion medium for about 24 to about 96 hours;
(c) splitting the cells obtained in (b) and further expanding the cells in the NPBSCs expansion medium; and
(d) repeating step (c) at least two times; thereby obtaining cells that
(1) express SOX1, MSX1 and PHOX2B and do not express NKX6.1 and VCAM-1; or
(2) express SOX2, IRX3, and MSX1 and do not express HOXB8, HOXA5 and VCAM-1;wherein expression of SOX1, MSX1, PHOX2B, NKX6.1, VICAM-1, SOX2, IRX3, HOXB8 and HOXA5 is determined by detecting mRNA.
US Pat. No. 10,711,246

METHODS AND COMPOSITIONS FOR GENERATING EPICARDIUM CELLS

UNIVERSITY HEALTH NETWORK...

1. A method of specifying a WT1+ cardiovascular progenitor cell population comprising the step of contacting an hPSC-derived KDR+ and PDGFRalpha+ cardiovascular mesoderm cell population with a cardiovascular progenitor specification cocktail comprising human BMP4 at a concentration of between 0.63 ng/ml and 10 ng/ml.
US Pat. No. 10,709,713

NANOPARTICULATE MELOXICAM FORMULATIONS

BAUDAX BIO, INC., Malver...

1. A method of treating moderate to severe pain in an adult human in need thereof comprising:administering once a day to the adult human an intravenous bolus injection of a meloxicam formulation to achieve a mean AUCinf of 107508.7±34443.0 ng*hr/ml in the adult human,
wherein the meloxicam formulation consists of 30 milligrams of nanoparticulate meloxicam, water, a surface stabilizer and a pharmaceutically acceptable excipient,
wherein the nanoparticulate meloxicam has an effective average particle size of less than about 150 nm;
wherein the meloxicam formulation comprises no more than 6,000 meloxicam particles that are greater than 10 ?m in size and no more than 600 meloxicam particles that are greater than 25 ?m in size; and
wherein the surface stabilizer is adsorbed on the surface of the nanoparticulate meloxicam and is essentially free of intermolecular cross-linkages.
US Pat. No. 10,711,252

SHIGELLA BACTERIOPHAGES AND USES THEREOF

INTRALYTIX, INC., Columb...

1. A composition comprising an isolated bacteriophage SHFML-26 deposited under ATCC Deposit Accession No. PTA-121236, SHFML-11 deposited under ATCC Deposit Accession No. PTA-121234, SHSML-45 deposited under ATCC Deposit Accession No. PTA-121238, SHSML-52-1 deposited under ATCC Deposit Accession No. PTA-121241, SHBML-50-1 deposited under ATCC Deposit Acquisition No. PTA-121239, SHBML-50-2 deposited under ATCC Deposit Accession PTA-121240, SHSML-52-2 deposited under ATCC Deposit Accession PTA-121242, SHSML-36 deposited under ATCC Deposit Accession PTA-121237, SHFML-21 deposited under ATCC Deposit Accession No. PTA-121235, an isolated progeny thereof, a variant thereof, or a combination thereof,wherein said variants have the same phenotypic characteristics of said deposited bacteriophage,
wherein said deposited bacteriophage and variants thereof have the same lytic activity against Shigella species strains,
wherein said variants have a Restriction Fragment Length Polymorphism (RFLP) profile of their DNA obtained by digesting their DNA with a restriction enzyme, said RFLP having the same number of bands and the corresponding bands are the same apparent size as the RFLP profile of said deposited bacteriophage's DNA obtained by digesting said deposited bacteriophage's DNA with the same restriction enzyme,
wherein the composition is a pharmaceutical composition, food product, dietary supplement, probiotic, and/or prebiotic,
wherein the composition is formulated as a lyophilized or spray-dried powder, an enteric capsule, a tablet, or a syrup, wherein the bacteriophage in the syrup is stabilized with an effective amount of an agent selected from the group consisting of: a water-soluble polymer or sugar, a derivative of cellulose, a low or medium molecular weight polyvinylpyrrolidone, a glycol with a molecular weight of 4000 or 6000, sodium alginate, a protein, a lipid, a polysaccharide, and a mixture thereof.
US Pat. No. 10,711,254

DUCK ENTERITIS VIRUS AND THE USES THEREOF

CEVA SANTE ANIMALE, Libo...

1. A method of vaccinating or immunizing poultry against Duck Enteritis Virus (DEV), comprising administering to said poultry a DEV having an inactive UL4 gene, said DEV optionally comprising a foreign nucleic acid.
US Pat. No. 10,711,256

GENETIC CORRECTION OF MUTATED GENES

Duke University, Durham,...

1. An engineered transcription activator-like effector nuclease (TALEN) protein that binds to a dystrophin gene, wherein the TALEN protein binds upstream from a premature stop codon on the dystrophin gene, downstream from a premature stop codon on the dystrophin gene, a region in exon 51 of the dystrophin gene, or a region in the 5? UTR of the dystrophin gene, wherein the TALEN protein comprises an amino acid sequence selected from the group consisting of the amino acid sequence of SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, and SEQ ID NO: 15.
US Pat. No. 10,709,720

HUMAN MILK OLIGOSACCHARIDES FOR MODULATING INFLAMMATION

Abbott Laboratories, Abb...

1. A method of inhibiting the growth of respiratory viruses in an infant, toddler, or child, the method comprising:identifying an infant, toddler, or child having a respiratory virus; and
administering to the infant, toddler, or child a nutritional composition comprising lacto-N-neotetraose in a concentration of from about 0.001 mg/mL to about 0.2 mg/mL.
US Pat. No. 10,712,284

METHOD FOR GRAFTING A COLOURED INDICATOR ONTO A SOLID SUBSTRATE AND IMPLEMENTATION KIT

1. A method for grafting, in a covalent manner, onto a surface of a solid substrate, a coloured indicator having at least one aromatic primary amine function, comprising the following steps:a) preparing, from said coloured indicator having at least one aromatic primary amine function, a corresponding diazonium salt;
b) placing the solid substrate in contact with a solution containing the diazonium salt prepared in step (a) and subjecting said solution to non-electrochemical conditions for an optimal grafting time whereby organic chains comprising units that are derivatives of said diazonium salt are grafted, in a covalent manner, onto the surface of said solid substrate;
c) washing the solid substrate thus grafted;
d) repeating steps (b) and (c) or possibly steps (a) to (c) at least once;
wherein said optimal grafting time is determined for a given coloured indicator by a method involving:
?) carrying out a plurality of grafting experiments, each grafting experiment being carried out for a period of time T, regularly subdivided into n sub-periods, n being a whole number greater than or equal to 1 that is different for each grafting experiment,
each sub-period corresponding to a step of free-radical chemical grafting of the coloured indicator onto the surface of a solid substrate and each grafting step being followed by at least one washing step,
?) after the period of time T, determining a quantity of coloured indicator grafted for each grafting experiment, normalising the quantity determined for each grafting experiment with respect to a quantity determined for the grafting experiment in which n is equal to 1, and determining an experiment E for which the normalised quantity is maximum whereby the optimal grafting time is T/ne with ne corresponding to a value of n during the experiment E, and T corresponding to the period of time T during the experiment E.
US Pat. No. 10,711,262

STORAGE-STABLE ENZYME GRANULES

1. A granule having a core, which core comprises a homogeneous mixture comprising an enzyme in soluble form and a polyamine having a molecule with at least 10% w/w of nitrogen wherein at least 50% of the N atoms are present as amines, wherein the enzyme is free of covalent links to the polyamine.
US Pat. No. 10,709,729

COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF ADAMTS-5 AND ADAM17

GUANGZHOU INSTITUTES OF B...

1. A pharmaceutical composition comprising at least one siRNA targeted against ADAMTS-5, and at least one siRNA targeted against ADAM17, and optionally a pharmaceutically acceptable carrier, wherein the sense strand of the double-stranded siRNA targeted against ADAMTS-5 comprises a nucleotide sequence of SEQ ID NO: 3, and the antisense strand of double-stranded siRNA targeted against ADAMTS-5 comprises a nucleotide sequence of SEQ ID NO: 4, and wherein the sense strand of the double-stranded siRNA targeted against ADAM17 comprises a nucleotide sequence of SEQ ID NO: 7, and the antisense strand of the double-stranded siRNA targeted against ADAM17 comprises a nucleotide sequence of SEQ ID NO: 8.
US Pat. No. 10,709,732

HYPERTONIC PHARMACEUTICAL COMPOSITIONS CONTAINING AN ANTI-PLATINUM CHEMOPROTECTANT AGENT

Decibel Therapeutics, Inc...

1. A hypertonic pharmaceutical composition having a calculated osmolarity of 1,500-7,000 mOsm/L and comprising 0.5M-2.0M of an anti-platinum chemoprotectant agent, a gelling agent, and an optional tonicity agent; wherein the calculated osmolarity is calculated based on the chemoprotectant agent and the tonicity agent, if present.
US Pat. No. 10,711,270

HIGH EFFICIENCY LIBRARY-IDENTIFIED AAV VECTORS

University of Massachuset...

1. A chimeric AAV capsid protein comprising distinct polypeptide regions derived from at least three different AAV serotypes selected from the group consisting of: AAV1, AAV2, AAV4, AAV5, AAV6, AAV8, AAV9, AAVrh8, AAVrh10, AAVrh39, and AAVrh43, wherein the chimeric AAV capsid protein comprises the sequence as set forth in any one of SEQ ID NOs: 5-8.
US Pat. No. 10,709,735

IMMUNOTHERAPY AGAINST NEURONAL AND BRAIN TUMORS

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has glioblastoma, comprising administering to said patient a population of activated CD8+cytotoxic T cells that kill the cancer cells that aberrantly present a peptide consisting of the amino acid sequence selected from SEQ ID NOs: 1, 2, 4, and 6-11 on the cell surface, wherein the peptide is in a complex with an WIC class I molecule, wherein the activated CD8+cytotoxic T cells are autologous to the patient, wherein the activated CD8+cytotoxic T cells are produced by contacting T cells in vitro with an antigen presenting cell comprising the peptide in a complex with an WIC class I molecule on the surface of the antigen presenting cell, for a period of time sufficient to activate said T cell.
US Pat. No. 10,709,737

PEPTIDES AND COMBINATION OF PEPTIDES OF NON-CANONICAL ORIGIN FOR USE IN IMMUNOTHERAPY AGAINST DIFFERENT TYPES OF CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has cancer, comprising administering to said patient a population of activated T cells that kill cancer cells that present a peptide consisting of the amino acid sequence of SEQ ID NO: 37,wherein said cancer is selected from colorectal cancer (CRC), gastric cancer (GC), hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC).
US Pat. No. 10,711,274

RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS

University of Massachuset...

1. A synthetic miRNA comprising 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 21 consecutive nucleotides encoded by a sequence set forth in SEQ ID NO: 17, and flanking regions of miR-155.
US Pat. No. 10,709,740

IN VITRO PRE-CONDITIONED BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AND USES THEREOF

THE JOHNS HOPKINS UNIVERS...

1. A method of treating an enteric nervous system disorder comprising:administering to a subject in need thereof a pharmaceutical composition comprising:
a pharmaceutically acceptable carrier; and
an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (BMSCs),
wherein the BMSC population express at least one neuronal marker,
wherein the at least one neuronal marker is selected from the group consisting of PGP9.5, NSE, Tuj1, HuC/D, and neuronal nitric oxide synthase (nNOS); and
regenerating a population of cells expressing at least one neuronal marker in the subject, wherein the at least one neuronal marker of the regenerated cell population is selected from the group consisting of PGP9.5, nNOS, Tuj1 and/or HuC/D, and
wherein the regenerated cells do not originate from the administered BMSCs.
US Pat. No. 10,711,278

GENETICALLY ALTERED ALFALFA PRODUCING CLOVAMIDE AND/OR RELATED HYDROXYCINNAMOYL AMIDES

The United States of Amer...

1. An expression cassette comprising a heterologous promoter operably linked to a cDNA, said cDNA comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, a sequence that is at least 95% identical to SEQ ID NO: 1, and a sequence that is at least 95% identical to SEQ ID NO: 3,wherein said cDNA encodes a protein with hydroxycinnamoyl-CoA:L-DOPA/tyrosine hydroxycinnamoyl transferase activity.
US Pat. No. 10,709,744

PROBIOTIC BIOFILM SUPPOSITORIES

MYBIOTICS PHARMA LTD., N...

1. A composition in the form of a suppository, comprising:(i) at least one viable probiotic bacteria in the form of dried biofilm;
(ii) a first agent comprising an antibiotic agent;
(iii) a first lipophilic carrier; and
optionally (iv) a pH adjusting agent,
wherein said at least one probiotic bacteria is 10% to 50% (w/w) of the total composition, and
wherein said at least one probiotic bacteria and said antibiotic agent are homogeneously dispersed within said first lipophilic carrier.
US Pat. No. 10,711,281

ADENO-ASSOCIATED VIRAL (AAV) VECTORS USEFUL FOR TRANSDUCING ADIPOSE TISSUE

1. An adeno-associated viral (AAV) vector selected from the group consisting of AAV6, AAV7, AAV8 and AAV9, comprising a recombinant viral genome wherein said recombinant viral genome comprises AAV Inverted Terminal Repeats (ITRs) and an expression cassette comprising an adipose tissue-specific transcriptional regulatory region operatively linked to a polynucleotide of interest, said vector further comprising a capsid of AAV serotype 6, AAV serotype 7, AAV serotype 8 or AAV serotype 9, wherein said polynucleotide is specifically expressed in adipocytes of a mammal after administration of the vector to the mammal.
US Pat. No. 10,711,282

OPTIMIZED LENTIVIRAL TRANSFER VECTORS AND USES THEREOF

Novartis AG, Basel (CH) ...

1. A lentiviral transfer vector comprising a heterologous nucleic acid sequence and being characterized by the following features:(a) comprising a cytomegalovirus (CMV) promoter,
(b) comprising a polynucleotide encoding at least a portion of a gag protein that comprises a mutated INS1 inhibitory sequence that reduces restriction of nuclear export of RNA relative to wild-type INS1,
(c) not comprising a polynucleotide encoding the INS2, INS3, and INS4 inhibitory sequences of gag, and
(d) not comprising an SV40 origin of replication and/or an f1 origin of replication.
US Pat. No. 10,710,002

METHOD OF EXTRACTING NUTRIENTS FROM A PLANT

NUECOLOGY BIOMEDICAL INC....

1. A method of extracting nutrients from a plant, comprising:(a) pulverizing a first plant material of the plant so as to obtain a first pulverized plant part containing a water-soluble nutrient and a plant juice;
(b) pulverizing a second plant material so as to obtain a second pulverized plant part containing a lipid-soluble nutrient;
(c) subjecting the first pulverized plant part to a fractional distillation under an increasing temperature gradient at a pressure in a range from 0.01 kPa to 202.2 kPa to obtain a liquid distillate fraction and a first residue that contains a water-soluble nutrient,
wherein the distillate includes three separated distillate fractions: a first distillate fraction collected at a temperature of lower than 50° C., a second distillate fraction collected at a temperature ranging from 50° C. to 70° C., and a third distillate fraction collected at a temperature ranging from 70° C. to 90° C.; and
(d) immersing the second pulverized plant part in a liquid distillate fraction at a temperature in a range from 5° C. to 75° C. for 1 hour to 48 hours to form a mixture followed by distilling the mixture at a temperature in a range from 40° C. to 90° C. for 0.5 hours to 10 hours to obtain a second residue that is a second extract that contains the lipid-soluble nutrient,
wherein the water-soluble nutrient is selected from the group consisting of vitamin C, ?-aminobutyric acid, salvianolic acid, norbixin, catechin, citric acid, anthocyanidin, and combinations thereof, and
wherein the lipid-soluble nutrient is selected from the group consisting of vitamin E, curcumin, tashinone, phytosterol, chlorophyll, and combinations thereof.
US Pat. No. 10,711,283

PRIMARY CELL GENE EDITING

PACT PHARMA, INC., South...

1. A composition comprising a polynucleotide, wherein the polynucleotide comprises:a. first and second homology arms homologous to first and second target nucleic acid sequences;
b. a TCR gene sequence positioned between the first and second homology arms;
c. a first P2A-coding sequence positioned upstream of the TCR gene sequence and a second P2A-coding sequence positioned downstream of the TCR gene sequence, wherein the first and second P2A-coding sequences code for the same amino acid sequence that are codon-diverged relative to each other;
d. a sequence coding for the amino acid sequence Gly Ser Gly positioned immediately upstream of the P2A-coding sequences; and
e. a sequence coding for a Furin cleavage site positioned upstream of the second P2A-coding sequence.
US Pat. No. 10,711,284

CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING

THE REGENTS OF THE UNIVER...

1. A single vector comprising at least one synthetic oligonucleotide, wherein the at least one synthetic oligonucleotide comprises the following covalently-linked components: (i) two nucleic acids each encoding a gRNA sequence targeting a target region in a cell; (ii) a region homologous to the target region comprising a change in sequence relative to the target region; and (iii) a site conferring immunity to nuclease-mediated editing.
US Pat. No. 10,709,748

ENCAPSULATED CANNABINOID FORMULATIONS FOR TRANSDERMAL DELIVERY

NUTRAE, LLC, Sarasota, F...

1. A cannabinoid composition capable of trans canal delivery, comprising:a cannabinoid composition further comprising:
a cannabinoid preparation ranging from 0.1% to 20% (w/w);
at least one surfactant ranging from 5% to 50% (w/w);
at least one co-solvent ranging from 10% to 70% (w/w);
water ranging from 16% to 60% (w/w); and
wherein the cannabinoid composition is capable of topical application and wherein the cannabinoid preparation is encapsulated by surfactants to form micelles having uni-, bi-, or multi-lamellar structures.
US Pat. No. 10,711,031

METHOD FOR EXTRACTING PHYTOSTEROLS FROM TALL OIL PITCH

ORGKHIM BCH MANAGEMENT CO...

1. A method for extracting phytosterols from tall oil pitch, the method consisting of saponifying tall oil pitch with an alkali in a polyatomic alcohol, extracting unsaponified matter from the alkali-alcohol solution using a hydrocarbon solvent, subsequently removing the solvent by distillation, and concentrating the phytosterols, wherein a mixture of paraffin hydrocarbons with 8 to 17 carbon atoms is used as the hydrocarbon solvent, and, following the extraction, botulin is isolated from the extract solution by crystallization at a temperature of 50 to 83° C. and the phytosterols are then concentrated by means of rectification.
US Pat. No. 10,709,755

SOLID FORMULATION AND METHOD FOR PREVENTING OR REDUCING COLORATION THEREOF

1. A solid formulation characterized by comprising:(A) 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N—{(R)-1?-phenyl-1?-[N?-(carboxymethyl)carbamoyl]methyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,5-benzothiazepine, or a pharmaceutically acceptable salt, solvate, or solvate of such a salt, wherein the solid formulation comprises:
one core, wherein said core is a homogenous mixture comprising ingredient (A), and
one coating layer or capsule layer enclosing at least a part of said core, wherein said coating layer or capsule layer comprises (C) polyvinyl alcohol and does not comprise (b) polyethylene glycol
wherein said coating layer or capsule layer comprises said ingredient (C) in an amount ranging from 50 to 90% by weight based on the total weight of the coating layer or capsule layer.
US Pat. No. 10,711,293

METHODS FOR DISTINGUISHING AND IDENTIFYING PLANT VARIETIES

Syngenta Participations A...

1. A method of distinguishing a first transgenic maize plant from a second maize plant, the method comprising the steps of:a. heating a solution of a milled transgenic maize plant part from a first transgenic maize plant comprising event 3272 expressing a heterologous thermotolerant 797GL3 alpha-amylase enzyme to a temperature above a gelatinization temperature of starch, wherein the temperature is between about 60° C. to about 100° C.;
b. continuously measuring viscosity changes of the solution for a time period of about 10 seconds to about 2 minutes, which results in only partial hydrolysis of starch;
c. obtaining a viscosity curve for the first transgenic maize plant based on the measurements of step (b); and
d. comparing the viscosity curve from the first transgenic maize plant to a viscosity curve obtained in the same manner from a second maize plant, wherein differences in the slopes of the viscosity curves distinguish the first transgenic maize plant from the second maize plant.
US Pat. No. 10,711,038

AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS

Bausch Health Ireland Lim...

1. A method for treating Irritable Bowel Syndrome (IBS) comprising:administering daily orally to a patient an effective dosage of a guanylate cyclase receptor agonist having the amino acid sequence of SEQ ID NO:1, wherein said agonist is a [4,12;7,15] bicyclic peptide, and
administering to said patient an effective dose of a cGMP-dependent phosphodiesterase inhibitor comprising sulindac sulfone or zaprinast, either concurrently or sequentially with said agonist.
US Pat. No. 10,709,759

SELF-REPLICATING CELL SELECTIVE GENE DELIVERY COMPOSITIONS, METHODS, AND USES THEREOF

University of South Flori...

1. A polyribonucleotide comprising:an RNA molecule of interest (ROI), wherein the ROI comprises a nucleic acid sequence encoding a protein, wherein the protein comprises BAX, PTEN, p16, P15, P18, P19, P21, P57 or CDKN3;
a microRNA (miRNA) target sequence operatively linked to the ROI, wherein the miRNA target sequence is a target for miR-126, miR-122, miR-208, miR-145, or miR-143; and
an RNA molecule comprising a nucleic acid sequence encoding a viral RNA replicase operatively linked to the ROI, the miRNA target sequence, or both the ROI and miRNA target sequence.
US Pat. No. 10,711,041

LYOPHILISATE CONTAINING A CYCLIC PEPTIDE OF FORMULA X1-GQRETPEGAEAKPWY-X2

APEPTICO FORSCHUNG UND EN...


wherein
X1 comprises an amino acid sequence, with 1 to 4 members, comprising natural and unnatural amino acids, and
X2 comprises a natural amino acid, and wherein
X1 comprises the N-terminal amino acid in position 1 on the left in formula I, and X2 comprises the C-terminal amino acid in the ultimate, right position in formula I,
wherein the cyclic peptide is in the form of a lyophilisate prior to mixing with the water,
wherein the aqueous aerosol includes particles of the water and the cyclic peptide, the particles having a diameter less than or equal to 5 ?m,
wherein the cyclic peptide, when in solution, remains fully active for a period of at least 7 days, and
wherein the cyclic peptide, when in a lyophilized form, remains fully active at room temperature for a period of at least 6 months.
US Pat. No. 10,709,761

METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING CANCER

UNIVERSITY OF UTAH RESEAR...

1. A method of inhibiting human cancer, which comprises contacting a human cancer cell with(a) one or more nucleic acids each having a sequence encoding an elephant p53 protein, selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 12, SEQ ID NO: 20 and combinations thereof, or
(b) one or more elephant p53 proteins each having a sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 13, SEQ ID NO: 21 and combinations thereof, whereby the human cancer is inhibited by causing the human cancer cell to undergo apoptosis.
US Pat. No. 10,711,042

STABILIZED VIRAL CLASS I FUSION PROTEINS

1. A method for treating a viral infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a pre-fusion class I fusion protein or a nucleic acid molecule encoding the pre-fusion class I fusion protein, wherein the pre-fusion class I fusion protein comprises one or more mutations in the hinge-loop that is present between the base helix and the RR1, wherein the one or more mutations comprise a mutation of one or more hydrophobic amino acid residues into Pro, and wherein the class I fusion protein is a Filovirus fusion F protein, a retroviral envelope protein, or an influenza hemagglutinin (HA) protein.
US Pat. No. 10,710,278

METHOD FOR PRODUCING AN ELASTOMERIC SKIN HAVING A GRAINED SURFACE

1. A method for producing an elastomeric skin, wherein said skin has at least a portion which has a grained surface having valleys and peaks, which comprises at least one elastomeric skin layer and which has at least one coating layer overlying the skin layer, which method comprises the steps of:applying a low viscosity coating composition, comprising effect pigment particles contained in a transparent or translucent medium, onto at least a portion of a mould surface, which portion is grained by having valleys and peaks to produce said coating layer, said mould surface having a grain depth and said coating layer having an average dry thickness which is smaller than said grain depth; and
moulding said elastomeric skin layer at least against a back side of said coating layer to produce said portion of the elastomeric skin,
wherein said low viscosity coating composition has a viscosity of less than 800 centistoke at the temperature of the mould surface and is a liquid coating composition or is liquefied when being applied and said coating layer of said portion of the elastomeric skin has a thickness that is smaller in the valleys of said portion of the elastomeric skin than in the peaks of said portion of the elastomeric skin.
US Pat. No. 10,711,046

METHOD FOR ESTABLISHING EUKARYOTIC EXPRESSION CELL LINE OF CD36 MUTANT GENE THAT ENCODES CD36 DEFICIENCY

NAN-NING INSTITUTE OF TRA...

1. A method for establishing eukaryotic expression cell line of CD36 mutant gene that encodes CD36 deficiency, the method comprising:(1) extracting total RNA from a whole blood sample derived from a CD36-deficient individual, and amplifying a coding sequence (CDS) in CD36 mRNA in the total RNA by Reverse Transcription PCR (RT-PCR) using a pair of primers, to obtain a cDNA sequence fragment of the mutant CD36 gene (MT-CD36 cDNA), wherein the pair of primers comprise an upstream primer YC-36F having a sequence of SEQ ID NO: 1, and a downstream primer YC-36R having a sequence of SEQ ID NO: 2;
2) using the MT-CD36 cDNA obtained in (1) as a template, a forward primer CD36-F2, and a reverse primer CD36-R3 to PCR-amplify a target sequence of MT-CD36-EGFP-1 comprising an EcoR 1 cleavage site and protective bases, a full-length coding sequence (CDS) excluding the terminator of CD36 cDNA, a fusion gene BamH I and protective bases, and a portion of a 5?-terminal sequence of an EGFP fluorescent reporter gene, wherein the forward primer CD36-F2 has a sequence of SEQ ID NO: 3, and the reverse primer CD36-R3 has a sequence of SEQ ID NO: 4;
using a eukaryotic plasmid pEGFP-N1 comprising the EGFP fluorescent reporter gene as a template, a forward primer EGFP-F4, and a reverse primer EGFP-R2 to PCR-amplify a target sequence of MT-CD36-EGFP-2 comprising a portion of the 3?-terminal fragment of the CD36 CDS cDNA, the fusion gene BamH I and protective bases, a full-length of the EGFP fluorescent reporter gene, and an XhoI cleavage site and protective bases, wherein the forward primer EGFP-F4 has a sequence of SEQ ID NO: 5, and the reverse primer EGFP-R2 has a sequence of SEQ ID NO: 6; and
performing Gene Splicing by Overlap Extension PCR (SOE-PCR) using the MT-CD36-EGFP-1 and MT-CD36-EGFP-2 as templates and CD36-F2 and EGFP-R2 as primers to obtain a mutant gene sequence of MT-CD36-EGFP;
(3) constructing and amplifying a MT-CD36-EGFP-pLV4/StripII-HIS10 eukaryotic expression vector by ligating the MT-CD36-EGFP of (2) to a pLV4/StripII-HIS10 vector; the MT-CD36-EGFP-pLV4/StripII-HIS10 eukaryotic expression vector comprising the full-length CDS excluding the terminator of the mutant CD36 cDNA and the EGFP fluorescent gene; and
(4) transfecting the MT-CD36-EGFP-pLV4/StripII-HIS10 eukaryotic expression vector into a CHO-K1 cell line by using virus-mediated transfection of eukaryotic cells, and screening and constructing a eukaryotic cell line MT-CD36-CHO-K1 expressing the mutant CD36 gene that encodes CD36 deficiency.
US Pat. No. 10,711,302

PREDICTING RESISTANCE TO DISEASE

AquaGen AS, Trondheim (N...


US Pat. No. 10,711,048

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST LUNG CANCER, INCLUDING NSCLC, SCLC AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that selectively recognize cells that present a peptide consisting of the amino acid sequence of QYQNVLTLW (SEQ ID NO: 31), wherein the cancer is selected from lung cancer, brain cancer (GBM), gastric cancer (GC), hepatocellular carcinoma (HCC), melanoma (MEL), non-Hodgkin lymphoma (NHL), prostate cancer and benign prostate hyperplasia (PRCA), renal cell carcinoma (RCC), and uterine cancer (UEC).
US Pat. No. 10,711,051

MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS

ZYMEWORKS INC., Vancouve...

1. A heteromultimer comprising:(i) a first monomeric protein that comprises a first transporter polypeptide comprising a first segment of albumin, and at least one cargo polypeptide, and
(ii) a second monomeric protein that comprises a second transporter polypeptide comprising a second segment of albumin, and at least one cargo polypeptide;
wherein the first segment of albumin and the second segment of albumin are derived from an albumin by segmentation of the albumin, the first transporter polypeptide is different from the second transporter polypeptide, and the transporter polypeptides self-assemble to form a quasi-native albumin structure.
US Pat. No. 10,711,307

METHOD FOR DETERMINING STATE OF DIFFERENTIATION OF STEM CELLS, AND NOVEL DIFFERENTIATION MARKER USED THEREFOR

FUJIFILM WAKO PURE CHEMIC...

1. A method for preparing differentiated stem cells comprising:(a) subjecting undifferentiated stem cells to differentiation-inducing treatment,
(b) detecting an expression of FOXB2 gene in the stem cells, and
(c) isolating the stem cells in which the expression of FOXB2 gene is detected.
US Pat. No. 10,709,771

METHOD FOR PREVENTING OR TREATING DIABETIC RETINOPATHY

TALENGEN INTERNATIONAL LI...

1. A method for preventing and/or treating retinopathy caused by diabetes mellitus in a subject, comprising administering an effective amount of plasminogen to the subject, wherein the plasminogen is selected from Glu-plasminogen, Lys-plasminogen, mini-plasminogen, micro-plasminogen, ? (delta)-plasminogen or any combination thereof.
US Pat. No. 10,711,052

METHOD FOR PROMOTING WOUND HEALING

UNIVERSITY OF SOUTHERN CA...

1. A method for treating or accelerating healing of a wound in the skin of a subject having epidermolysis bullosa, comprising:intravenously administering to the subject having epidermolysis bullosa and the skin wound an effective amount of a pharmaceutical composition comprising recombinant human collagen type VII protein comprising an alpha chain having a collagenous triple-helical segment.
US Pat. No. 10,711,308

MUTATION SIGNATURES FOR PREDICTING THE SURVIVABILITY OF MYELODYSPLASTIC SYNDROME SUBJECTS

DANA-FARBER CANCER INSTIT...

1. A method of aggressively treating myelodysplastic syndrome (MDS) in a subject, the method comprising:(a) detecting whether one or more protein sequence-disrupting mutations is present in each of genes TP53, ETV6, EZH2, RUNX1 and ASXL1 in a polynucleotide sample obtained from a subject, using a nucleic acid detection assay;
(b) diagnosing the subject as needing aggressive treatment for MDS when one or more mutations is detected in two or more of the TP53, ETV6, EZH2, RUNX1 and ASXL1 genes; and
(c) administering an effective amount of an aggressive drug regimen comprising azacytidine, decitabine, lenalidomide, and/or bone marrow transplantation, to the subject diagnosed in step (b) to aggressively treat MDS.
US Pat. No. 10,711,053

INSULIN LIKE PEPTIDES

1. A method for making a chimeric polypeptide comprising two different peptide chains, wherein the two different peptide chains are chain A from one insulin like peptide and chain B from a different insulin like peptide, wherein chain A is selected from the A chain of insulin (INS), INSL3 (RLF), INSL4, INSL5, INSL6 (RIF-1), Relaxin 1 (RLN1), Relaxin 2 (RLN2), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor 2 (IGF-2), and chain B is selected from the B chain of insulin (INS), INSL3 (RLF), INSL4, INSL5, INSL6 (RIF-1), Relaxin 1 (RLN1), Relaxin 2 (RLN2), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor 2 (IGF-2); the method comprising(i) combining a chain A which contains at least two disulfide bonds, with a chain B which contains at least one disulfide bond, in the presence of a reducing agent; or
(ii) combining a chain A which contains at least two disulfide bonds, with a chain B which contains at least two cysteine residues, in the presence of dimethyl sulfoxide (DMSO);
thereby making the chimeric polypeptide.
US Pat. No. 10,711,310

TERT PROMOTER MUTATIONS IN GLIOMAS AND A SUBSET OF TUMORS

Duke University, Durham,...

1. A method of identifying a mutation in a human subject and treating a human subject, comprising:subjecting a nucleic acid sample obtained from a tumor of the human selected from the group consisting of: glioma, astrocytoma, oligodendroglioma, and oligoastrocytoma, to a reaction whereby reaction products are formed;
detecting in the reaction products from the human tumor a somatic mutation at nucleotide chr5 1,295,228 in hg19; and
administering to the subject with the somatic mutation a therapy selected from the group consisting of chemotherapy, radiotherapy, biological therapy, or surgery.
US Pat. No. 10,709,775

CELLS FOR IMMUNOTHERAPY ENGINEERED FOR TARGETING CD38 ANTIGEN AND FOR CD38 GENE INACTIVATION

Cellectis, Paris (FR)

1. An anti-CD38 specific chimeric antigen receptor (anti-CD38 CAR) comprising an extra cellular ligand binding-domain comprising VH and VL from a monoclonal anti-CD38 antibody, a hinge, a transmembrane domain, and a cytoplasmic domain comprising a CD3 zeta signaling domain and a co-stimulatory domain from 4-1BB,wherein said VH and VL comprise the CDRs sequences of respectively SEQ ID NO.15-17 and SEQ ID NO.11-13; respectively SEQ ID NO.63-65 and SEQ ID NO.59-61; respectively SEQ ID NO.55-57 and SEQ ID NO.51-53; respectively SEQ ID NO.31-33 and SEQ ID NO.27-29; respectively SEQ ID NO.39-41 and SEQ ID NO.35-37; respectively SEQ ID NO.47-49 and SEQ ID NO.43-45; respectively SEQ ID NO.23-25 and SEQ ID NO.19-21.
US Pat. No. 10,711,056

AGLYCOSYLATED ANTI-PROPERDIN ANTIBODIES

NOVELMED THERAPEUTICS, IN...

1. A method for reducing antibody-mediated classical complement pathway activation, comprising administering to a subject an engineered form of a parent antibody which binds to properdin, the engineered antibody contains a human heavy chain IgG1 CH1 portion and a human IgG2 Fc portion, wherein the engineered antibody comprises a substitution at position 297 from asparagine (N) to Alanine (A) or Glutamine (Q) in the CH2 region of said heavy chain constant region that prevents glycosylation of the substitution position.
US Pat. No. 10,709,777

SALMONELLA PARATYPHI A WITH AN O-ANTIGEN HAVING AN EXTENDED CARBOHYDRATE CHAIN AND USE THEREOF

Institute of Biotechnolog...

1. A recombinant strain, which is obtained by introducing a cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium into Salmonella paratyphi A which is deficient in cld gene encoding an enzyme controlling chain length of O-antigen;wherein the amino acid sequence of the enzyme controlling chain length of the O-antigen of Salmonella typhimurium has the amino acid sequence as shown in SEQ ID NO: 2.
US Pat. No. 10,711,315

METHOD FOR PRODUCING RNA

1. A method for producing purified mRNA on a preparative scale comprising the following steps:a) providing a template DNA comprising a nucleic acid sequence encoding a mRNA sequence;
b) in vitro transcription of the template DNA in order to obtain a composition comprising the mRNA;
c) purification of a preparative quantity of the mRNA obtained in step b) by purification steps comprising, at least:
i) oligo dT-based affinity purification; and
ii) RP-HPLC,
thereby producing a preparative quantity of purified mRNA.
US Pat. No. 10,711,316

PRIMERS AND KITS FOR COLONY MULTIPLEX PCR FOR THE DETECTION OF CLASS A, B, C, AND D BETA-LACTAMASE GENES AND METHODS OF USING THEREOF

MYONGJI UNIVERSITY INDUST...

1. A method for treating a patient with bacterial infection, the method comprising:determining a ?-lactamase (bla) gene of a bacterial pathogen in the patient by performing a multiplex polymerase chain reaction (PCR) with primer pairs;
determining a ?-Lactam antibiotics to which the bacterial pathogen is not resistant, in accordance with the determination of the ?-lactamase (bla) gene; and
administering the ?-Lactam antibiotics to the patient,
wherein the primer pairs comprise:
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 1 and 2, a pair of Seq. 3 and 4, a pair of Seq. No. 5 and 6, a pair of Seq. No. 7 and 8, a pair of Seq. No. 9 and 10, a pair of Seq. No. 11 and 12, a pair of Seq. No. 13 and 14, and a pair of Seq. No. 15 and 16;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 17 and 18, a pair of Seq. No. 19 and 20, a pair of Seq. No. 21 and 22, a pair of Seq. No. 23 and 24, and a pair of Seq. No. 25 and 26;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 27 and 28, a pair of Seq. No. 29 and 30, a pair of Seq. No. 31 and 32, a pair of Seq. No. 33 and 34, a pair of Seq. No. 35 and 36, a pair of Seq. No. 37 and 38, a pair of Seq. No. 39 and 40, and a pair of Seq. No. 41 and 42;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 43 and 44, a pair of Seq. No. 45 and 46, a pair of Seq. No. 47 and 48, a pair of Seq. No. 49 and 50, a pair of Seq. No. 51 and 52, a pair of Seq. No. 53 and 54, No. 55 and 56, and a pair of Seq. 57 and 58;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 59 and 60, a pair of Seq. No. 61 and 62, a pair of Seq. No. 63 and 64, a pair of Seq. No. 65 and 66, and a pair of Seq. No. 67 and 68;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 69 and 70, a pair of Seq. No. 71 and 72, a pair of Seq. No. 73 and 74, a pair of Seq. No. 75 and 76, a pair of Seq. No. 77 and 78;
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 79 and 80, a pair of Seq. No. 81 and 82, a pair of Seq. No. 83 and 84, a pair of Seq. No. 85 and 86, a pair of Seq. No. 87 and 88, a pair of Seq. No. 89 and 90, a pair of Seq. No. 91 and 92, and a pair of Seq. No. 93 and 94; and
at least two primer pairs selected from the primer pair group consisting of a pair of Seq. No. 95 and 96, a pair of Seq. No. 97 and 98, a pair of Seq. No. 99 and 100, a pair of Seq. No. 101 and 102, a pair of Seq. No. 103 and 104, a pair of Seq. No. 105 and 106, and a pair of Seq. No. 107 and 108.
US Pat. No. 10,709,522

REACTIVE MICRO APPLICATOR WITH METAL-CONTAINING ADDITIVES FOR USE IN DENTAL ADHESIVES

KULZER GMBH, Hanau (DE)

21. Method of affecting the polymerization of a dental material, the method comprising providing at least one additive selected from metals, metal-containing compounds, and organometallic compounds at or on an application aid by contacting the at least one additive to a polymerizable dental adhesive, wherein the at least one additive comprises as the at least one additive catalytically active platinum in form of platinum sponge, wherein the application aid is impregnated, at least in part, with nano-particulate platinum, wherein the nano-particulate platinum has a particle size of less than or equal to 10 nm, and wherein the nano-particulate platinum is platinum sponge.
US Pat. No. 10,709,780

INTEGRIN ACTIVATOR VACCINE COMPOSITIONS

7 Hills Pharma LLC, Hous...

1. A composition comprising:(A) an antigen, and
(B) an adjuvanting amount of at least one integrin activating compound that increases an immune response to the antigen,
wherein the at least one integrin activating compound comprises one or more compounds of the general Formula (I):
R1-M1-N(R2)-M2-M3-M4-M5-M6-R3  (I)
wherein a first class of the compounds of Formula (I) is defined by:
R1 is selected from the group consisting of aryl and aralkyl,
R2 is alkyl, aryl, or aralkyl,
M1 is CH2,
M2 is CO,
M3 is O, S, or NR6,
R6 when present is hydrogen or lower alkyl,
M4 is absent or CH2,
M5 is (CR11R12),
R11 is hydrogen,
R12 is selected from the group consisting of hydrogen, NR21CONR22R23, NR21COR24, NR21SO2R24, NR21COOR24, OCOR24, OR24, O(CH2CH2O)sR24, COOR24, alkyl, and hydroxyalkyl,
s is an integer of 1 to 6,
R21 and R22 when present are independently selected from the group consisting of hydrogen or lower alkyl,
R23 when present is selected from the group consisting of hydroxyalkyl, alkoxyalkyl, alkyl, aryl, aralkyl and alkoxycarbonylalkyl,
 provided that when M3 is NR6 and M4 is absent, then R23 is not 1-(1,3-benzodioxol-5-yl)-3-ethoxy-3-oxopropyl,
R24 when present is selected from the group consisting of alkyl, aryl, aralkyl, heterocyclyl, cycloalkyl, cycloalkylalkyl, and heterocyclylalkyl, and mixtures thereof,
M6 is (CH2)q, where
q is an integer from 0 to 6,
R3 is selected from the group consisting of hydrogen, CONR13R14, NR15COOR16, NR15COR16, NR15CONR13R14, NR15SO2R16, OCOR16, COOR16, OR16, SR16, heterocyclyl, hydroxyl, hydroxyalkyl, guanadino, alkyl and aryl,
R13 and R15 when present are independently hydrogen or lower alkyl,
R14 and R16 when present are independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl, cycloalkylalkyl, and heterocyclylalkyl,
R1, R2, R3, R12, R14, R16, R23 and R24 when present may independently be either unsubstituted or substituted with one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heterocyclylaryl, hydroxy, alkoxy, azido, haloalkoxy, hydroxyalkyl, aryloxy, hydroxyaryl, alkoxyaryl, halo, haloalkyl, haloaryl, amino, alkylamino, dialkylamino, arylamino, diarylamino, —NHCO(alkyl), —NHCO(aryl), —NHCO(aralkyl), —NHCO(haloalkyl), —NHSO2(alkyl), —NHSO2(aryl), —NHSO2(aralkyl), alkoxycarbonyl, alkoxycarbonylalkyl, —OCO(alkylamino), —OCO(dialkylamino), and mixtures thereof;orwherein a second class of the compounds of Formula (I) is defined by:
R1 is aryl or aralkyl,
R2 is alkyl or aralkyl,
M1 is CH2,
M2 is CO,
M3 is absent or is O or CH2,
M4 is absent or is CH2,
M5 is absent or is O or (CR11R12),
R11 is hydrogen,
R12 is selected from the group consisting of hydrogen, NR21CONR22R23,
NR21COR24, NR21SO2R24 and NR21COOR24,
R21 and R22 each of which, when present is independently selected from the group of hydrogen and lower alkyl,
R23 and R24, each of which, when present is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl,
M6 is selected from the group consisting of (CH2)q, (CH2)q—CH?CH—(CH2)r, (CH2)q-arylene-(CH2)r and (CH2CH2O)q, where
q and r are independently integers from 0 to 6,
R3 is CONR13R14,
R13 and R14, each of which, when present is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl, and
R1, R2, R13, R14, R23 and R24, when present, independently either are unsubstituted or are substituted with one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heterocyclylaryl, hydroxy, alkoxy, azido, haloalkoxy, hydroxyalkyl, aryloxy, hydroxyaryl, alkoxyaryl, halo, haloalkyl, haloaryl, amino, alkylamino, dialkylamino, arylamino, diarylamino, —NHCO(alkyl), —NHCO(aryl), —NHCO(aralkyl), —NHCO(haloalkyl), —NHSO2(alkyl), —NHSO2(aryl), —NHSO2(aralkyl), alkoxycarbonyl, alkoxycarbonylalkyl, —OCO(alkylamino), —OCO(dialkylamino), and mixtures thereof;orwherein a third class of the compounds of Formula (I) is defined by:
R1 is aryl or aralkyl,
R2 is alkyl or aralkyl,
M1 is CH2,
M2 is SO2, or CO,
M3 is absent or is CH2,
M4 is absent or is CH2,
M5 is absent or is (CR11R12),
R11, when present, is hydrogen,
R12, when present, is selected from the group consisting of hydrogen, alkyl,
NR21CONR22R23, NR21COR24, NR21SO2R24 and NR21COOR24,
R21 and R22, each of which when present, is independently selected from the group of hydrogen, lower alkyl, and aralkyl,
R23 and R24, each of which, when present is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl,
M6 is (CH2)q, or NR34(CH2)q,
q is an integer from 0 to 6,
R34, when present, is selected form the group consisting of alkyl, aralkyl, COR35, and SO2R35,
R35 when present, is selected form the group consisting of alkyl, aryl, and aralkyl, and
R3 is selected from the group consisting of CONR13R14, SO2NR13R14, NR15COOR16, NR15COR16, NR15CONR13R14, and NR15SO2R16,
R13 and R14, each of which, when present, is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl,
R15 and R16, each of which when present, is independently selected from the group of hydrogen, lower alkyl, and aralkyl,
R1, R2, R13, R14, R15, R16, R23, R24, R34 and R35, when present, either are unsubstituted or are substituted with one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heterocyclylaryl, hydroxy, alkoxy, azido, haloalkoxy, hydroxyalkyl, aryloxy, hydroxyaryl, alkoxyaryl, halo, haloalkyl, haloaryl, amino, alkylamino, dialkylamino, arylamino, diarylamino, —NHCO(alkyl), —NHCO(aryl), —NHCO(aralkyl), —NHCO(haloalkyl), —NHSO2(alkyl), —NHSO2(aryl), —NHSO2(aralkyl), alkoxycarbonyl, alkoxycarbonylalkyl, —OCO(alkylamino), and —OCO(dialkylamino), with the proviso that when M2 is CO, then M6 is NR34(CH2)q,
wherein q is not 0;orwherein a four class of the compounds of Formula (I) is defined by:
R1 is alkyl, aryl or aralkyl,
R2 is selected from the group consisting of aralkyl and alkyl,
provided that when R1 is alkyl, R2 is aralkyl,
M1 is CO or SO2,
provided that when M1 is SO2 and R1 is phenyl, 4-methylphenyl or 2,4,6-trimethylphenyl, R2 is not alkyl, 2-phenethyl, benzyl, or 2-methoxy-2-oxoethyl, and when M1 is CO and R1 is 2-furyl, 4-pyridyl, or 3,5-dinitrophenyl, R2 is not alkyl, benzyl or 2-(1H-indol-2-yl)ethyl,
M2 is absent or CH2,
M3 and M4 are absent,
M5 is (CR11R12),
R11 is hydrogen,
R12 is selected from the group consisting of hydrogen, NR21CONR22R23, NR21COR24, NR21SO2R24, NR21COOR24, CONR22R23, COOR24, O(CH2CH2O)sR24, hydroxyalkyl, and alkoxyalkyl,
R21, and R22, when present, are independently selected from the group consisting of hydrogen and C1-C6 alkyl, and
R23 and R24, each of which, when present, is independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl, and
s is an integer of 1 to 6,
M6 is (CH2)q,
q is an integer of 0 to 6,
R3 is selected from the group consisting of NR15COOR16, NR15COR16, NR15CONR13R14, and NR15SO2R16, and
R13 when present, is independently selected from the group consisting of hydrogen and C1-C6 alkyl, and
R14, R15, and R16 each of which, when present, are independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl and aralkyl, and
R1, R2, R3, R12, R14, R15, R16, R23, and R24, when present, independently either are unsubstituted or are substituted with one or more substituents selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heterocyclylaryl, hydroxy, alkoxy, azido, haloalkoxy, hydroxyalkyl, aryloxy, hydroxyaryl, alkoxyaryl, halo, haloalkyl, haloaryl, amino, alkylamino, dialkylamino, arylamino, diarylamino, —NHCO(alkyl), —NHCO(aryl), —NHCO(aralkyl), —NHCO(haloalkyl), —NHSO2(alkyl), —NHSO2(aryl), —NHSO2(aralkyl), alkoxycarbonyl, alkoxycarbonylalkyl, —OCO(alkylamino) and —OCO(dialkylamino),orpharmaceutically acceptable salts thereof.
US Pat. No. 10,712,341

BIOSENSOR

Duke University, Durham,...

1. A method of assaying for glutamate in a sample, comprising contacting a biosensor with said sample under conditions such that said biosensor is able to bind to glutamate present in said sample, wherein said biosensor comprises Escherichia coil E. coli) glutamate/aspartate binding protein (EBP) comprising a reporter group attached at amino acid position 126 of said E. coil EBP, wherein said E. coli EBP comprises the amino acid sequence set forth in SEQ ID NO: 3, and wherein binding of glutamate in a glutamate-binding pocket of said biosensor causes a change in signaling by said reporter group.
US Pat. No. 10,711,318

MICROBIAL STRAIN FOR ELECTROSYNTHESIS AND ELECTROFERMENTATION

UNIVERSITY OF MASSACHUSET...

1. A genetically engineered Geobacter sulfurreducens strain, wherein the strain comprises a genetically engineered modification resulting from the insertion of a genetic element encoding ATP-citrate lyase (EC 2.3.3.8), wherein the strain is capable of effectively growing on a cathode under anaerobic conditions with electrons derived solely from the cathode as electron donor source.
US Pat. No. 10,712,342

DIAGNOSTIC TO DISTINGUISH BACTERIAL INFECTIONS

Arizona Board of Regents ...

1. An array comprising at least two peptides that are capable of differentially binding to one or more antibodies produced in response to a bacterial infection or to one or more antibodies produced in response to a viral infection, wherein said array comprises SEQ ID NO.1 and SEQ ID NO.2.
US Pat. No. 10,711,063

NEUTRALIZATION OF INHIBITORY PATHWAYS IN LYMPHOCYTES

INNATE PHARMA, Marseille...

1. A method of treating a cancer in a human patient, the method comprising administering to the patient an effective amount of each of: (a) an antibody that neutralizes human NKG2A, and (b) an antibody that neutralizes human PD-L1, wherein the antibody that neutralizes human NKG2A comprises the CDR1, CDR2 and CDR3 domains of a heavy chain having the sequence set forth in any one of SEQ ID NOS: 4-8, and the CDR1, CDR2 and CDR3 domains of a light chain having the sequence set forth in SEQ ID NO: 9 and the antibody that neutralizes human PD-L1 is selected from nivolumab, lambrolizumab, pembrolizumab, atezolizumab, or pidlizumab.
US Pat. No. 10,711,319

METHOD FOR TREATING CELLULOSIC MATERIAL

SilvaNova, LLC, Plymouth...

1. A method comprising(i) contacting a cellulose-comprising input material with an aqueous hydrolyzing solution comprising at least 35% wt. of at least one mineral acid to form a hydrolyzate comprising a mixture of water-soluble carbohydrates and optionally a solid fraction;
(ii) contacting said hydrolyzate with an extractant comprising a first solvent S1, to form (a) a solid first residue comprising precipitated carbohydrates and (b) an acid-comprising extract;
(iii) separating said acid-comprising extract from said solid first residue;
(iv) modifying said acid-comprising extract to form (a) a liquid second residue comprising dissolved carbohydrates and (b) an acid-comprising modified extract, wherein said modifying said acid-comprising extract comprises combining said extract with a second solvent S2;
(v) fractionating said modified extract into an S1-enriched fraction and an acid-enriched fraction;
(vi) reusing said S1-enriched fraction to form said extractant; and
(vii) reusing said acid-enriched fraction to form said aqueous hydrolyzing solution; wherein
(a) at least 10% wt. of the cellulose is hydrolyzed and said mixture of water-soluble carbohydrates comprises monosaccharides, disaccharides and/or oligosaccharides;
(b) S1 forms a single phase when mixed with an identical weight of 70% sulfuric acid aqueous solution at 25° C.;
(c) S1 is at least 65% wt. of said extractant; and
(d) said acid-comprising extract comprises at least 60% wt. of the acid and at least 5% wt. of the carbohydrates in said hydrolyzate.
US Pat. No. 10,712,343

MOLECULAR ANALYSIS OF TUMOR SAMPLES

The General Hospital Corp...

1. A method for treating an intra-abdominal tumor in a subject, the method comprising:obtaining a sample from the subject, wherein the sample is not from breast or lung tissue;
detecting levels of biomarkers consisting of MUC-1, HER2, EGFR, and EpCAM in the sample by contacting the sample with antibodies or antigen-binding fragments thereof that bind to MUC-1, HER2, EGFR, and EpCAM and are labeled with superparamagnetic cross-linked iron oxide (CLIO) nanoparticles having a hydrodynamic diameter of 28.8 nm;
comparing the levels of MUC-1, HER2, EGFR, and EpCAM in the sample to reference levels; and
administering a treatment for cancer to a subject who has levels of MUC-1, HER2, EGFR, and EpCAM above the reference levels.
US Pat. No. 10,711,064

LYM-1 AND LYM-2 TARGETED CAR CELL IMMUNOTHERAPY

University of Southern Ca...

1. A chimeric antigen receptor (CAR) comprising: (a) an antigen binding domain of an anti-HLA-DR antibody; (b) a CD8 ? hinge domain; (c) a CD8 ? transmembrane domain; (d) a CD28 costimulatory signaling region and/or a 4-1BB costimulatory signaling region; and (e) a CD3 zeta signaling domain, wherein the antigen binding domain of an anti-HLA-DR antibody comprises:(i) a heavy chain variable region comprising SEQ ID NO: 8 and a light chain variable region comprising SEQ ID NO: 18; or
(ii) a heavy chain variable region comprising SEQ ID NO: 10 and a light chain variable region comprising SEQ ID NO: 20.
US Pat. No. 10,711,065

ANTI-FLT-1 ANTIBODIES IN TREATING BRONCHOPULMONARY DYSPLASIA

1. A method of treating bronchopulmonary dysplasia (BPD) in an infant comprising administering to an infant in need of treatment an effective amount of an anti-Flt-1 antibody or antigen fragment thereof, wherein the anti-Flt-1 antibody or antigen fragment thereof comprises:a VL CDR1 defined by the amino acid sequence of SEQ ID NO: 21,
a VL CDR2 defined by the amino acid sequence of SEQ ID NO: 24,
a VL CDR3 defined by the amino acid sequence of SEQ ID NO: 32,
a HL CDR1 defined by the amino acid sequence of SEQ ID NO: 3,
a HL CDR2 defined by the amino acid sequence of SEQ ID NO: 12, and
a HL CDR3 defined by the amino acid sequence of SEQ ID NO: 17.
US Pat. No. 10,711,067

TREATMENT OF POST-PRANDIAL HYPERINSULINEMIA AND HYPOGLYCEMIA AFTER BARIATRIC SURGERY

XOMA (US) LLC, Emeryvill...

1. A method of treating post-prandial hypoglycemia following bariatric surgery, comprising administering to a subject in need thereof an antibody that is a negative modulator of insulin binding to the insulin receptor and/or insulin action at the insulin receptor in an amount effective to ameliorate post-prandial hypoglycemia, wherein the antibody comprises three heavy chain CDRs set out in SEQ ID NO: 11-13 and three light chain CDRs set out in SEQ ID NO: 26-28.
US Pat. No. 10,711,323

STEEL SHEET, AND PRODUCTION METHOD THEREFOR

JFE Steel Corporation, T...

1. A steel sheet having a composition comprising, in mass %,C: 0.05% or more and 0.20% or less,
Si: 0.60% or more and 1.65% or less,
Mn: 1.8% or more and 3.5% or less,
P: 0.05% or less,
S: 0.005% or less,
Al: 0.08% or less, and
N: 0.0060% or less,
the balance being Fe and inevitable impurities,
the steel sheet having a metallographic structure containing, in terms of an area ratio, ferrite of 25% or more and 65% or less, martensite having iron-based carbides precipitated in the grains thereof of 35% or more and 75% or less, and the balance structure other than the ferrite and the martensite having the iron-based carbides precipitated in the grains thereof of 20% or less (including 0%) in total,
average grain diameters of the ferrite and the martensite having the iron-based carbides precipitated in the grains thereof being respectively 5 ?m or lower, and
a total of concentrations of Si and Mn at interface between the ferrite and the martensite having the iron-based carbides precipitated in the grains thereof being, in terms of an atomic concentration, 5% or more, and
the steel sheet having a tensile strength of 900 MPa or higher.
US Pat. No. 10,709,787

HYDROGELS OF METHACRYLIC HYALURONIC ACID DERIVATIVES FOR ORAL ENZYME THERAPY IN CELIAC DISEASE

NEMYSIS LIMITED, Dublin ...

1. A composition comprising:at least one exogenous enzyme, said enzyme being selected from the group consisting of prolyl endopeptidase (PEP), endoprotease (EP) and combinations thereof, said enzyme in a concentration between 1 mU/mg and 100 U/mg being entrapped in an HA-EDA-MA hydrogel; and
trehalose in a concentration between 0.1 and 10% w/w with respect to the weight of the HA-EDA-MA hydrogel;
wherein the HA-EDA-MA hydrogel is formed by photocrosslinking HA-EDA-MA derivatives;
wherein the HA-EDA-MA derivatives is formed from hyaluronic acid (HA) or a salt thereof, having a molecular weight between 50,000 and 1,500,000 Daltons, and is formed via activation of at least one hydroxyl group of HA with a carbonating agent chosen between carbonic phenylesters and haloformic phenylesters followed by functionalization of the activated hydroxyl group by reaction with ethylenediamine (EDA) and subsequent reaction with methacrylic anhydride (MA); and wherein the composition is in the form of a freeze dried powder.
US Pat. No. 10,712,349

CIRCULATING KIM-1 LEVELS FOR DETECTION OF PATHOLOGIES ASSOCIATED WITH INJURY TO, OR CANCER OF, THE KIDNEY

1. An assay for diagnosing kidney injury or Renal Cell Carcinoma (RCC) in a subject and treating the subject, consisting essentially of:a. contacting a blood sample obtained from a subject identified to have, or at risk of having a kidney injury, with an anti-KIM-1 antibody that specifically binds to a KIM-1 polypeptide of (SEQ ID NO: 1), and measuring the binding between the KIM-1 polypeptide and the anti-KIM-1 antibody;
b. comparing the level of the KIM-1 polypeptide in the blood sample with a reference level of the KIM-1 polypeptide;
c. selecting the subject as having a kidney injury or Renal Cell Carcinoma (RCC) when the level of KIM-1 polypeptide in the blood sample is 4-fold higher, or greater than 4-fold higher than the reference level for the KIM-1 polypeptide; and
d. administering an effective treatment for treating kidney disease to the subject selected as being diagnosed with a kidney injury or RCC.
US Pat. No. 10,709,789

LOW PROTEIN PERCENTAGE GELLING COMPOSITIONS

Keranetics, Inc., Winsto...

1. A composition comprising keratose, kerateine or a combination thereof, wherein said composition forms a hydrogel at a protein concentration of less than 20%,wherein said keratose, kerateine or combination thereof is prepared by a method including dialyzing said keratose, kerateine or combination thereof at a transmembrane pressure of from about 30 psi to about 70 psi, and
wherein said hydrogel exhibits a dynamic complex viscosity of at least 113.9 Pascals as measured at 25.degree. Celsius at a frequency of 1 Hertz.
US Pat. No. 10,710,045

CAPSULES CONTAINING MAMMALIAN CELLS

CAPSUM, Marseilles (FR)

1. A microcapsule comprising:a liquid core;
a stiff intermediate envelope comprising at least one biopolymer; and
at least one external envelope totally encapsulating the liquid core at its periphery,
said intermediate envelope being located between the liquid core and the external envelope,
said external envelope being able to retain the liquid core when the microcapsule is immersed in a gas and comprising at least one gelled polyelectrolyte and/or one stiffened biopolymer,
said microcapsule further comprising at least one eukaryotic mammalian cell, wherein the liquid core comprises at least one keratinocyte and the intermediate envelope comprises at least one fibroblast; and
said stiff intermediate envelope having an elastic modulus that is non-zero.

US Pat. No. 10,715,766

WEARABLE CAMERA SYSTEM AND RECORDING CONTROL METHOD

PANASONIC I-PRO SENSING S...

1. A wearable camera system comprising:a wearable camera, which in use, is mounted on a user; and
a camera capable of communicating with the wearable camera;
wherein the wearable camera includes:
a first capture, which, in operation, captures an image of a capturing area,
a first recorder, which, in operation, records a first image captured by the first capture in a first memory,
a recording switch, operation of which causes the first recorder to record the first image, and
a communication mode switch including a first communication mode position, a second communication mode position and a third communication mode position, a communication mode of the wearable camera is different when the communication mode switch is in the first communication mode position, when the communication mode switch is in the second communication mode position and when the communication mode switch is in the third communication mode position,
wherein the camera includes:
a second recorder, which, in operation, records a second image captured by the camera in a second memory, and
wherein the wearable camera, in response to operation of the recording switch and depending on which of the first communication mode position, the second communication mode position and the third communication mode position is occupied by the communication mode switch, executes a first recording mode in which the recording of the first image to the first memory starts and a signal is transmitted to the camera which causes the camera to record the second image in the second memory, executes a second recording mode in which the recording of the first image to the first memory is started and the signal to the camera is not transmitted or executes a third recording mode in which recording of the first image to the first memory starts, the wearable camera wirelessly connects automatically to an access point and the wearable camera is connected with a mobile terminal of the user, at least one image chosen from a current image captured by the first capture, the recorded first image and a still image is displayed on the mobile terminal and a recording start trigger indicating a factor by which the recording of the first image started which is linked to the recorded first image is displayed on the mobile terminal.

US Pat. No. 10,711,893

BRAKE FOR UNINTENDED NEUTRAL MODE IN TRANSFER CASE

BorgWarner Inc., Auburn ...

1. A product comprising:an output shaft, wherein the output shaft includes a radial flange having a plurality of teeth;
a range shifter operatively connected to the output shaft, wherein the range shifter is constructed and arranged to selectively shift a vehicle between a low range mode, a high range mode, and a neutral mode;
a mode shifter operatively connected to the output shaft, wherein the mode shifter is constructed and arranged to shift the vehicle between a four-wheel drive mode and a two-wheel drive mode;
a dual drive gear operatively attached to the output shaft and interposed between the range shifter and the mode shifter, wherein the dual drive gear is constructed and arranged so that rotation of the dual drive gear drives the range shifter and the mode shifter;
at least one plunger radially displaced around the output shaft; and
wherein the dual drive gear is constructed and arranged to actuate the at least one plunger during a range shift so that the at least one plunger engages a slot between the plurality of teeth on the radial flange to prevent rotation of the output shaft, wherein the dual drive gear includes a radial cam surface, wherein the at least one plunger comprises a first sleeve and a second sleeve that is coaxial with the first sleeve, the first sleeve being cylindrical and having a top surface and a body having a first end and a second end, the first end having a first radial lip extending outward from an outer diameter of the first sleeve, and the second end having a radial lip which extending outward from an inner diameter of the first sleeve, the second sleeve constructed and arranged to fit within the inner diameter of the first sleeve, the second sleeve including a body having a first surface, a second surface, and a second radial lip extending therebetween, the second radial lip constructed and arranged to sit on the first radial lip on the second end of the first sleeve, the second surface of the second sleeve having a diameter which is less than the diameter of the first surface of the second sleeve, a cam follower spring surrounding a portion of the first sleeve and sitting against the first radial lip on the first end of the first sleeve, the cam follower spring constructed and arranged to ensure that the at least one plunger follows the radial cam surface during a range shift, the radial cam surface being eccentric to the output shaft so that when a range shift is initiated, the cam follower spring compresses causing the at least one plunger to engage the output shaft by entering into a slot between the teeth on the radial flange of the output shaft grounding the output shaft to a shift support to prevent rotation of the output shaft and therefore rolling of the vehicle during a range shift, the at least one plunger including a blocking spring interposed within the first end of the first sleeve so that the second sleeve is spring-loaded against the first sleeve.

US Pat. No. 10,711,220

HIGH TEMPERATURE HEAT-RESISTANT OIL-BASED RELEASE AGENT, HIGH TEMPERATURE HEAT-RESISTANT ELECTROSTATIC APPLICATION-TYPE OIL-BASED RELEASE AGENT, AND APPLICATION METHOD THEREFOR

AOKI SCIENCE INSTITUTE CO...

1. An oil-based release agent comprisinga petroleum-based hydrocarbon solvent (a),
an adhesive (b), wherein adhesive (b) is dimethyl polysiloxane having a weight average molecular weight of 100,000 or more, and
a conductive modifier (f), wherein the conductive modifier (f) is at least one selected from the group consisting of
an imidazolium salt (f-1),
a pyrrolidinium salt (f-2),
a pyridinium salt (f-3),
a phosphonium salt (f-5), and
a sulfonium salt (f-6);
wherein the release agent contains 0% water.

US Pat. No. 10,711,210

METHOD OF PREPARING METAL DIBORIDE DISPERSIONS AND FILMS

Arizona Board of Regents ...

1. A method of producing metal diboride nanomaterials comprising:preparing a mixture of at least one metal diboride and a suspending solution, the suspending solution including at least one solvent;
at least partially exfoliating the at least one metal diboride by exposing the mixture to ultrasonic energy comprising ultrasonic vibrations;
centrifuging the mixture and forming at least a lower phase and an adjacent supernatant, the supernatant including a dispersion of exfoliated metal diborides; and
extracting at least a portion of the dispersion from the supernatant;
wherein the at least one solvent is selected from N-methyl-2-pyrrolidone, dimethylformamide, cyclopentanone, cyclohexanone, N-formyl piperidine, vinyl pyrrolidone, 1,3-dimethyl-2-imidazolidinone, bromobenzene, benzonitrile, benzyl benzoate, N,N?-dimethylpropylene urea, y-butrylactone, N-ethylpyrrolidone, dimethylacetamide, cyclohexylpyrrolidone, dimethyl sulfoxide, dibenzyl ether, chloroform, isopropylalcohol, cholobenzene, 1-octyl-2-pyrrolidone, 1-3 dioxolane, ethyl acetate, quinoline, benzaldehyde, ethanolamine, diethyl phthalate, NDodecyl-2-pyrrolidone, pyridine, dimethyl phthalate, formamide, ethanol, vinyl acetate, acetone, ethylene glycol, toluene, heptane, hexane, and pentane.

US Pat. No. 10,711,197

LIQUID-CRYSTALLINE MEDIUM AND HIGH-FREQUENCY COMPONENTS COMPRISING SAME

MERCK PATENT GMBH, Darms...

1. A liquid-crystal medium comprising:one or more compounds selected from formulae I-3a to I-3d:

in which
R1 denotes H, unfluorinated alkyl or unfluorinated alkoxy having 1 to 17 C atoms or unfluorinated alkenyl, unfluorinated alkenyloxy or unfluorinated alkoxyalkyl having 2 to 15 C atoms;
one or more compounds selected from formula II:

in which
R2 denotes H, unfluorinated alkyl or unfluorinated alkoxy having 1 to 17 C atoms or unfluorinated alkenyl, unfluorinated alkenyloxy or unfluorinated alkoxyalkyl having 2 to 15 C atoms,
Z21 denotes trans-CH?CH—, trans-CF?CF— or —C?C—, and

independently of one another, denote

and one or more compounds selected from formula III-1b:

in which
R3 denotes H, unfluorinated alkyl or unfluorinated alkoxy having 1 to 17 C atoms or unfluorinated alkenyl, unfluorinated alkenyloxy or unfluorinated alkoxyalkyl having 2 to 15 C atoms,
wherein the amount of compounds of formula III-1b in said medium is in the range from 5 to 45 wt. %,
wherein the liquid-crystal medium has a clearing point of 90° C. or more,
wherein the medium has a material quality, ?, of 20 or more at 20° C. and 19 GHz, and
wherein the total concentration of compounds of formulae I-3a to I-3d, II, and III-1b is 90% to 100%.

US Pat. No. 10,711,175

COMPOSITIONS AND METHODS FOR CONTROLLING PARAFFIN AND ASPHALTENE PROBLEMS IN WELLS

Sasol Performance Chemica...

1. A composition for use in controlling heavy hydrocarbon deposits, including both paraffins and asphaltenes, in oil and gas wells comprising:A. an ether having the general formula:
R—O—R1  I
wherein R and R1 are each alkyl groups which, independent of each other, can be linear or branched containing from about 1 to about 29 carbon atoms, said ether being present in an amount of 40 wt % to 90 wt %
B. at least one additional component selected from the group consisting of:
(i) an ester of the formula:

wherein R2-R5 are linear or branched alkyl groups having from 1 to 30 carbon atoms and n is from 0 to 20;
(ii) an alkoxylated branched alcohol having the general formula:
CH3(CxH2x)—O—(CnH2nO)y—(C2H4O)z—H  IV
wherein x is from 3 to 30, n is from 2 to 4, y is from 0 to 6 and z is from 3 to 20;
(iii) mixtures of (i) and (ii); and C. a hydrocarbon co-solvent comprising a liquid hydrocarbon containing from about 6 to about 30 carbon atoms, and from about 20 to about 90 wt % or greater naphthenics, isoparaffins, or mixtures thereof.

US Pat. No. 10,711,171

ABRASIVE ARTICLE INCLUDING SHAPED ABRASIVE PARTICLES

1. A shaped abrasive particle comprising a body having a first major surface, a second major surface, and a side surface joined to the first major surface and the second major surface, a first exterior corner and a second exterior corner, wherein at least one edge defined by the joining of the side surface with the first major surface comprises a first discrete stepped depression having a first depression and a second depression, and wherein the first discrete stepped depression is spaced away from the first exterior corner and the second exterior corner.

US Pat. No. 10,710,877

METHOD AND APPARATUS FOR GENERATING HYDROGEN FROM FORMIC ACID

KOREA INSTITUTE OF SCIENC...

1. An apparatus for generating hydrogen by dehydrogenation of a formic acid, comprising:a reactor containing a heterogeneous catalyst, wherein the reactor has an opening within the reactor capable of feeding water to the reactor;
a syringe pummp connected to the reactor configured to supply a formic acid into the reactor;
a moisture remover connected to the reactor configured to remove moisture generated at the reactor; and
a cold trap bath configured to condense the moisture removed by the moisture remover and supply the condensed moisture as in a form of water to the reactor,
wherein the cold trap bath is connected to the reactor to supply the water to the reactor via the opening,
wherein the heterogeneous catalyst comprises a metal heterogeneous catalyst and a catalyst support,
wherein the metal heterogeneous catalyst is at least one selected from the group consisting of Pt, Rh, Ru, Au, Ag, Pd, Ni, Co, Cu, and Fe.

US Pat. No. 10,710,746

GROUND STATION AND TETHER FOR UNMANNED AERIAL VEHICLES

Stabilis Inc., South Pas...

1. An unmanned aerial vehicle system, comprising:a ground station, comprising:
a case;
a power supply housed in the case; and
a tether having a first end and a second end opposite to the first end, the first end of the tether coupled to the case; and
a module comprising smart battery authentication circuitry configured to be coupled to the second end of the tether,
wherein the module is configured to be connected to an unmanned aerial vehicle,
wherein the smart battery authentication circuitry enables the unmanned aerial vehicle to receive power from the power supply housed in the case when the module is connected to the unmanned aerial vehicle, and
wherein the ground station comprises a receptacle configured to accommodate the module.

US Pat. No. 10,710,064

PAG COMPRESSOR OIL CONDITIONING FILTER ELEMENT

SCHROEDER INDUSTRIES, LLC...

1. A PAG compressor oil conditioning filter element (10) configured for outside in flow comprising:a proximal end cap (22) and a distal end cap (24), wherein the proximal endcap (22) includes a central outlet (23) therein;
a cylindrical outer wrap (26) between the end caps (22 and 24) having perforations (28) there through on only a portion of the outer wrap (26) adjacent the distal end cap (24), wherein the flow (5) of PAG compressor oil is configured to flow into the element (10) through the perforations (28) in conventional operation;
an outer layer of ion exchange polymers beads (30) radially within the outer wrap (26) configured to remove acid from the treated PAG compressor oil;
an annular particulate removing micro-glass media (34) adjacent the proximal end cap (22) and radially within at least a portion of the outer layer of ion exchange polymers beads (30) and configured to remove particulates from the treated PAG compressor oil, wherein a distal end of the micro-glass media (34) is axially spaced from the portion of the outer wrap (26) having perforations (28) whereby the portion of the outer wrap (26) having perforations (28) is positioned axially closer to the distal end cap (24) than the distal end of the micro-glass media (34); and
a central flow area (36) radially within the particulate removing micro-glass media (34) and in fluid communication with the central outlet (23).

US Pat. No. 10,710,036

INSTALLATION AND METHOD FOR TREATING A PLASTIC MELT

Next Generation Recycling...

1. An installation (1) for treating a plastics melt, and setting the intrinsic viscosity thereof, having a reactor (2) which has a reactor housing (3) with at least one first reactor housing part (4) with an upper end region (6) and a lower end region (7) and which has a chamber part (8) extending between the upper and lower end regions (6, 7), wherein the first chamber part (8) has a vertical height extent, and the reactor housing (3) has, in the region of the lower end region (7) of the at least first reactor housing part (4), an at least second reactor housing part (5) which directly adjoins said first reactor housing part and which has a second chamber part (9), wherein the two chamber parts (8, 9) are connected to one another in terms of flow and are formed so as to be sealed off with respect to the external surroundings, and in the region of the upper end region (6) of the first reactor housing part (4), at at least one inlet opening, at least one feed line (10) for the plastics melt opens into the first reactor housing part (4), and at least one outlet opening (11) for the plastics melt is arranged in the second reactor housing part (5), and having at least one mixing element (12) which is arranged in the second reactor housing part (5), which mixing element (12) is mounted in the second reactor housing part (5) so as to be rotatable about an axis of rotation (13), and wherein the mixing element (12) is connected in terms of drive to a dedicated, independent first drive device (18),wherein the reactor (2) is supported on a standing surface with the interposition of at least one weight-determining device (21),
wherein a discharge device (19) for the plastics melt is arranged so as to adjoin the outlet opening (11) of the second reactor housing part (5), which discharge device is in the form of a melt pump or in the form of an extruder,
wherein the discharge device (19) is also supported on the standing surface with the interposition of at least one weight-determining device (21), and
wherein the discharge device (19) is connected in terms of drive to a second drive device (20), wherein the second drive device (20) is driven independently of the first drive device (18) of the mixing element (12).

US Pat. No. 10,710,035

FEED MIXTURE DISTRIBUTION DEVICE

OUTOTEC (FINLAND) OY, Es...

1. A feed mixture distribution device configured to evening out a feed of feed mixture in an annular feed mixture feed channel of a burner, wherein the feed mixture distribution device comprises:a cylindrical member having a cylindrical wall, a first end, a second end, and a longitudinal central axis X, and
wherein the cylindrical member is at the first end provided with rectangular flat plate means, which extend radially from the cylindrical wall of the cylindrical member and which are arranged symmetrically about the longitudinal central axis X of the cylindrical member,
wherein
the cylindrical wall of the cylindrical member is between the rectangular flat plate means and the second end provided with at least one helical plate means arranged symmetrically about the longitudinal central axis X of the cylindrical member,
each helical plate means extend towards the second end of the cylindrical wall of the cylindrical member in a helical manner about the longitudinal central axis X of the cylindrical member,
each helical plate means has a downstream end and a feed mixture bearing surface, wherein the width of the feed mixture bearing surface as measured along a line normal to the longitudinal central axis X of the cylindrical member decreases in a direction towards the downstream end of the helical plate means,
each helical plate means comprises an upstream helical plate section, which comprises a part of the feed mixture bearing surface and which extend towards the second end of the cylindrical member in a helical manner about the longitudinal central axis X of the cylindrical member and a downstream helical plate section, which comprises a part of the feed mixture bearing surface and which extend towards the second end of the cylindrical member in a helical manner about the longitudinal central axis X of the cylindrical member,
a slit between each upstream helical plate section of the helical plate means and each downstream helical plate section of the helical plate means,
the handedness of the upstream helical plate section of the helical plate means being different than the handedness of the downstream helical plate section of the helical plate means, and
the downstream end of the helical plate means being a part of the downstream helical plate section of the helical plate means.

US Pat. No. 10,710,028

MULTILAYER COMPOSITE MEMBRANE

Industrial Technology Res...

1. A multilayer composite membrane consisting essentially of the following layers:a porous support layer;
an inorganic porous layer consisting of a plurality of inorganic particles and located on the porous support layer;
a polymer porous layer located on the inorganic porous layer, the polymer porous layer has a porous structure connected to pores of the inorganic porous layer, wherein a thickness of the polymer porous layer is 30 microns to 60 microns; and
a separation layer located on the polymer porous layer.

US Pat. No. 10,709,888

SYSTEMS AND METHODS FOR MAKING AND USING AN ELECTRICAL STIMULATION SYSTEM FOR PERIPHERAL NERVE STIMULATION

BOSTON SCIENTIFIC NEUROMO...

1. An electrical stimulation lead, comprising:a lead body having a proximal end portion and a distal end portion, wherein the distal end portion has a smaller lateral width in at least one direction than a remainder of the lead body;
a plurality of terminals disposed at the proximal end portion of the lead body;
a plurality of electrodes disposed at the distal end portion of the lead body; and
a plurality of conductors extending along the lead body and electrically coupling the plurality of terminals to the plurality of electrodes.

US Pat. No. 10,709,876

BALLOON CATHETER

ABBOTT CARDIOVASCULAR SYS...

1. A catheter comprising:an outer shaft member having a proximal section and a distal outer member, the outer shaft member having an inflation lumen defined therethrough;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft, a proximal cone portion, a working length, a distal cone portion, and a distal balloon shaft, wherein the proximal balloon shaft is coupled to the distal outer member; and
an inner tubular member comprising a plurality of tubes connected together and having guidewire lumen defined therethrough, the inner tubular member extending from the outer shaft member proximal section through the distal outer member and through the balloon to form a tip,
wherein the distal balloon shaft has an inner diameter and comprises a distal seal portion coupled to the inner tubular member and a proximal portion free of attachment to the inner tubular member and monolithic with the distal seal portion, and wherein the inner diameter is constant across the proximal portion of the distal balloon shaft and the distal seal portion, and the length of the proximal portion of the distal balloon shaft is at least two times the inner diameter of the distal balloon shaft.

US Pat. No. 10,709,816

IMPLANT

Medizinische Hochschule H...

1. Implant useful for bone in-growth consisting exclusively of a sintered bulked volume of packed layers of scattered fibers of a magnesium master alloy containing greater than 50% magnesium and excluding each of aluminium, copper, and nickel except in traces of maximally 1%, wherein the fibers have a length ranging from 2 mm to 15 mm and are securely connected to each other by sintered bridges that are locally spaced vis-à-vis one another and thereby form an open-pored body, which implant disintegrates in a living being through biological adsorption.

US Pat. No. 10,709,794

PHOTODYNAMIC THERAPY COMPOSITION

CASE WESTERN RESERVE UNIV...

1. A method of treating cancer comprising:(a) administering to a subject with cancer a therapeutically effective amount of a composition comprising a pharmaceutical composition comprising a phthalocyanine compound or targeted conjugate thereof having the formula (I):

wherein X1 is hydrogen or includes a targeting moiety directly or indirectly coupled or conjugated to the thiol group;
R1, R4, R5, R8, R9, R12, R13, and R16 are each independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, thiol, amino, and methyl;
R2, R3, R6, R7, R10, R11, R14, and R15 are each independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, thiol, amino, carboxy, aryl, heteroaryl, carbocyclyl, heterocyclyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy, C1-6 acyl, C1-6 alkylcarbonyloxy, C1-6 carbocyclylalkyl, C1-6 aminoalkyl, alkylamino, C1-6 thioalkyl, C1-6alkylthio, C1-6hydroxyalkyl, C1-6 alkyloxycarbonyl, C1-6 alkylaminocarbonyl, and C1-6 alkylcarbonylamino; and pharmaceutically acceptable salts thereof; and
(b) exposing the phthalocyanine compound or targeted conjugate thereof to light, thereby inducing the cytotoxic effects of the phthalocyanine compound or targeted conjugate thereof.

US Pat. No. 10,709,757

PHARMACEUTICAL COMPOSITION FOR ANTI-ANGIOGENESIS CONTAINING CYCLIC PENTADEPSIPEPTIDE AS AN EFFECTIVE INGREDIENT

CHUNG-ANG UNIVERSITY INDU...

1. A method for inhibiting angiogenesis, wherein the method comprises administering a pharmaceutical composition for inhibiting angiogenesis, comprising an isolated cyclic pentadepsipeptide of the following Chemical Formula 1 as an effective ingredient, to a subject in need thereof,
wherein the peptadepsipeptide inhibits the proliferation of vascular endothelial cells.
US Pat. No. 10,709,715

METHOD OF TREATING HYPERTENSION

Cipla Limited, Mumbai (I...

1. A method of treating pulmonary hypertension in a patient in need thereof, comprising administering to the patient a composition comprising an effective amount of temozolomide or a pharmaceutically acceptable salt or ester thereof, and at least one excipient.

US Pat. No. 10,715,761

METHOD FOR PROVIDING VIDEO CONTENT AND ELECTRONIC DEVICE FOR SUPPORTING THE SAME

Samsung Electronics Co., ...

1. An electronic device, comprising:a memory configured to store a high-speed video captured with a first number of frames per second; and
a processor electrically connected with the memory and configured to:
detect an amount of image variation based on at least one frame of the high-speed video captured at the first number of frames per second,
generate a slow motion interval, a playback time of which is extended, by dividing the first number of frames per second into a second number of frames per second which is less than the first number of frames per second with respect to at least part of the high-speed video, wherein a number of frames per second in the slow motion interval generated by the division is less than the first number of frames per second, and
output the slow motion interval, the slow motion interval having less frames per second than the first number of frames per second, for display,
wherein the processor is further configured to:
detect candidate objects based on a preview image configured with some frames captured at the first number of frames per second,
display the candidate objects, and
detect an object selected by a user input among the candidate objects and generate the slow motion interval based on frames at times when the selected object has an amount of object variation of a level or more.

US Pat. No. 10,715,756

IMAGE SENSOR EMPLOYING AVALANCHE DIODE

PIXART IMAGING INC., Hsi...

1. An image sensor, comprising:a pixel array comprising a plurality of pixel circuits arranged in a matrix, each of the pixel circuits comprising:
an avalanche diode having an anode and a cathode, the cathode being connected to a positive bias voltage;
a resistive transistor, a drain of the resistive transistor connected to the anode of the avalanche diode, and a gate of the resistive transistor configured to receive a fixed voltage signal;
a first switch transistor, a drain of the first switch transistor connected to a source of the resistive transistor, a gate of the first switch transistor configured to receive an exposure signal, and a source of the first switch transistor connected to a ground voltage;
a pull down transistor, a gate of the pull down transistor connected to the anode of the avalanche diode, and a source of the pull down transistor connected to the ground voltage; and
a second switch transistor, a gate of the second switch transistor configured to receive the exposure signal, a source of the second switch transistor connected to a drain of the pull down transistor, and a drain of the second switch transistor configured to generate an output voltage; and
a plurality of pulling circuits each being configured to be coupled to the drain of the second switch transistor of each pixel circuit of one pixel circuit column via a readout line to read the output voltage.

US Pat. No. 10,714,181

MEMORY CELL

Taiwan Semiconductor Manu...

1. A cell structure for reducing negative bias temperature instability (NBTI), comprising:a first unit comprising a first group of transistors and a first data latch;
a second unit comprising a second group of transistors and a second data latch;
a read port unit comprising a plurality of p-type transistors, wherein the read port unit comprises a first p-type read port transistor and a second p-type read port transistor;
a search line and a complementary search line, wherein the search line and the complementary search line function as inputs to the cell structure; and
a master line, wherein the master line functions as an output of the cell structure,
wherein the first unit is operatively coupled to the second unit,
wherein both the first and the second units are operatively coupled to the read port unit,
wherein gate of the first p-type read port transistor is coupled to the complementary search line,
wherein source of the first p-type read port transistor is coupled to a power supply line,
wherein gate of the second p-type read port transistor is coupled to the first data latch,
wherein source of the second p-type read port transistor is coupled to the master line,.
where an initial state of the search line is set and kept to logic high before the cell structure enters each search operation mode,
wherein an initial state of the master line is set and kept to logic low before the cell structure enters each search operation mode.

US Pat. No. 10,713,358

SYSTEM AND METHOD TO EXTRACT AND UTILIZE DISASSEMBLY FEATURES TO CLASSIFY SOFTWARE INTENT

FireEye, Inc., Milpitas,...

1. A method to extract and utilize disassembly features to classify an intent of a software program, the method comprising:generating a model based, at least in part, on features associated with at least (i) one or more samples from labeled malicious software, and (ii) one or more samples from labeled benign software extracted from training files, the model to maintain statistics associated with each particular type of sample; and
classifying an unknown sample being a software program in accordance with the model being utilized by a classifier, the classifying of the software program comprises
disassembling the unknown sample being a software program selectable via a user interface, the disassembling includes parsing the software program, identifying machine code instructions within the parsed software program, and analyzing a structure of the software program by identifying at least one of code blocks, function boundaries, and stack frames, wherein at least one or more of the identified code blocks, function boundaries or stack frames corresponding to at least one feature of the unknown sample;
analyzing the at least one feature by a machine-learning algorithm operating in accordance with the model by comparing the at least one feature to features contained in the model, the machine-learning algorithm being executed by a hardware processor; and
classifying the software program based on a result yielded from the analyzing of the at least one feature.

US Pat. No. 10,712,450

INTELLIGENT SATELLITE EXCLUSION FOR MULTIPATH MITIGATION BASED ON LINE OF SIGHT

Honeywell International I...

1. A method of operating a global navigation satellite system receiver, the method comprising:receiving a plurality of signals from a plurality of satellites at a vehicle with the global navigation satellite system receiver;
using at least one controller in,
determining at least a measurement from and location of each satellite based on the received plurality of signals;
determining an approximate vehicle velocity vector based on the received plurality of signals;
determining a dot product between a line of sight between each satellite and a vehicle having the receiver and the determined vehicle velocity vector;
removing each measurement associated with each determined dot product that is below a minimum dot product threshold to obtain a resultant set of measurements;
determining a geometric reliability factor of the resultant set of measurements;
decreasing the dot product minimum threshold when the determined geometric reliability factor is more than a defined maximum geometric reliability factor threshold; and
determining a position solution based on the resultant set of measurements.

US Pat. No. 10,712,438

RADAR USING PERSONAL PHONE, TABLET, PC FOR DISPLAY AND INTERACTION

Honeywell International I...

1. A radar system comprising:a transmit array comprising a plurality of transmit antenna elements;
radar transmitter electronics in signal communication with the transmit array, wherein the radar transmitter electronics, in conjunction with the transmit array, are configured to output a frequency modulation continuous wave (FMCW) transmit beam that illuminates an area with a greater extent in a first illumination direction than in a second illumination direction,
wherein the second illumination direction is substantially perpendicular to the first illumination direction, and
wherein the transmit beam is fixed in the first illumination direction and the second illumination direction;
a receive array comprising a plurality of receive antenna elements;
radar receiver electronics operable to:
receive a plurality of receive signals from the receive array; and
processing circuitry operable to:
digitally form a receive beam from the plurality of receive signals;
determine one or more characteristics of a sub-area of the area illuminated by the fixed FMCW transmit beam, wherein the sub-area is within the receive beam;
establish communication with an external mobile computing device via an application program interface (API), wherein the communication comprises:
output a signal to the mobile computing device, wherein the signal comprises:
target detection information in three dimensions;
target movement characteristics, including relative velocity and angular velocity; and
receive inputs via the API to control one or more functions of the radar system.

US Pat. No. 10,712,420

SYSTEMS AND METHODS FOR CONCOMITANT FIELD CORRECTION IN MAGNETIC RESONANCE IMAGING WITH ASYMMETRIC GRADIENTS

Mayo Foundation for Medic...

1. A method for compensating first order concomitant field effects in data acquired with a magnetic resonance imaging (MRI) system having an asymmetric gradient system, the steps of the method comprising:(a) providing to a computer system, gradient waveforms that will be applied during data acquisition with the MRI system;
(b) computing with the computer system, compensatory gradient waveforms that when added to the provided gradient waveforms compensate for first order concomitant field effects;
(c) providing the gradient waveforms and the compensatory gradient waveforms to the MRI system; and
(d) acquiring data with the MRI system using a data acquisition that generates magnetic field gradients using the provided gradient waveforms and the provided compensatory gradient waveforms, wherein the acquired data are compensated for first order concomitant field effects by generating the magnetic field gradients using the provided gradient waveforms and the provided compensatory gradient waveforms.

US Pat. No. 10,711,890

CONTROL APPARATUS FOR VEHICLE DRIVE-FORCE TRANSMITTING APPARATUS

TOYOTA JIDOSHA KABUSHIKI ...

1. A control apparatus for a drive-force transmitting apparatus that is to be provided in a vehicle having a drive force source and drive wheels,wherein the drive-force transmitting apparatus includes:
an input rotary member to which a drive force is to be transmitted from the drive force source;
an output rotary member from which the drive force is to be outputted to the drive wheels;
a continuously-variable transmission mechanism configured to provide a continuously-variable gear ratio that is variable within a given range; and
a gear mechanism configured to provide at least a gear ratio that is higher than the continuously-variable gear ratio provided by the continuously-variable transmission mechanism,
wherein the drive-force transmitting apparatus defines a plurality of drive-force transmitting paths that are provided in parallel with each other between the input rotary member and the output rotary member such that the drive force is to be transmitted from the input rotary member to the output rotary member through an established one of the drive-force transmitting paths,
wherein the plurality of drive-force transmitting paths include a first drive-force transmitting path, through which the drive force is to be transmitted by the gear mechanism when the first drive-force transmitting path is established,
wherein the plurality of drive-force transmitting paths include a second drive-force transmitting path, through which the drive force is to be transmitted by the continuously-variable transmission mechanism when the second drive-force transmitting path is established,
wherein the drive-force transmitting apparatus is configured to establish a selected state that is one of (i) a first state in which the first drive-force transmitting path is established and (ii) a second state in which the second drive-force transmitting path is established, such that the selected state is switched from the first state to the second state when a state-switch-requiring shift-up action is executed in the drive-force transmitting apparatus,
wherein said control apparatus comprises a shift-up-action permitted gear-ratio setting portion configured to set a shift-up-action permitted gear ratio that is a value or a range of the continuously-variable gear ratio of the continuously-variable transmission mechanism, which makes the state-switch-requiring shift-up action permitted to be executed, such that the state-switch-requiring shift-up action requiring the selected state to be switched from the first state to the second state is permitted to be executed when the continuously-variable gear ratio of the continuously-variable transmission mechanism corresponds to said shift-up-action permitted gear ratio,
wherein said shift-up-action permitted gear-ratio setting portion is configured, when a running speed of the vehicle is not higher than a given value, to set a predetermined high gear ratio value as said shift-up-action permitted gear ratio, and
wherein said shift-up-action permitted gear-ratio setting portion is configured, when the running speed of the vehicle is higher than said given value, to set, as said shift-up-action permitted gear ratio, a predetermined gear ratio range ranging from said predetermined high gear ratio value to a predetermined low gear ratio value that is lower than said predetermined high gear ratio value.

US Pat. No. 10,710,948

PROCESSES FOR PREPARING (R)-1-(5-CHLORO-[1,1?-BIPHENYL] -2-YL)-2,2,2-TRIFLUOROETHANOL AND 1-(5-CHLORO-[1,1?-BIPHENYL]-2-YL)-2,2,2-TRIFLUOROETHANONE

Roivant Sciences GmbH, B...

1. A process of preparing a compound of Formula A:comprising reducing a compound of Formula B:in the presence of a chiral catalyst.

US Pat. No. 10,710,790

NESTED INSULATED PACKAGING

Pratt Corrugated Holdings...

1. A nested insulated packaging assembly comprising:an outer box including an outer top side wall, an outer bottom side wall, and a plurality of outer lateral side walls;
an inner corrugated cardboard portion positioned in the outer box, the inner corrugated cardboard portion including a plurality of inner lateral side walls, the plurality of inner later side walls defining a lateral outer surface and a lateral inner surface, the lateral inner surface disposed opposite from the lateral outer surface, the lateral inner surface at least partially defining an inner storage cavity within the inner corrugated cardboard portion, the lateral outer surface and the lateral inner surface each defined by corrugated cardboard;
a first thermal liner contacting the outer bottom side wall of the outer box; and
a second thermal liner contacting at least a first outer lateral side wall, a second outer lateral side wall, and a third outer lateral side wall of the plurality of outer lateral side walls of the outer box and at least a first inner lateral side wall, a second inner lateral side wall, and a third inner lateral side wall of the plurality of inner lateral side walls of the inner corrugated cardboard portion, the second thermal liner contacting the lateral outer surface, the second thermal liner comprising a left fold, a front fold, and a right fold, the second thermal liner defining an inner surface and an outer surface, a thickness of the second thermal liner being defined between the inner surface and the outer surface, a portion of the outer surface defined by the left fold contacting the first outer lateral side wall, a portion of the inner surface defined by the left fold contacting the first inner lateral side wall, a portion of the outer surface defined by the front fold contacting the second outer lateral side wall, a portion of the inner surface defined by the front fold contacting the second inner lateral side wall, a portion of the outer surface defined by the right fold contacting the third outer lateral side wall, a portion of the inner surface defined by the right fold contacting the third inner lateral side wall, the second thermal liner defining a first bend line between the left fold and the front fold, the portion of the inner surface defined by the left fold being connected to the portion of the inner surface defined by the front fold at the first bend line, the second thermal liner defining a second bend line between the front fold and the right fold, the portion of the inner surface defined by the front fold being connected to the portion of the inner surface defined by the right fold at the second bend line, the left fold defining a left side end of the second thermal liner, the right fold defining a right side end of the second thermal liner, the left side end defined opposite from the right side end, the thickness being uniform from the left side end to the right side end.

US Pat. No. 10,710,638

VEHICLE LOWER PORTION STRUCTURE

TOYOTA JIDOSHA KABUSHIKI ...

1. A vehicle lower portion structure comprising:a pair of rocker panels extending along a vehicle front-rear direction, the rocker panels being respectively arranged on both outer sides of a vehicular floor panel in a vehicle width direction; and
an electric power supply device arranged below the floor panel, wherein:
the rocker panel is configured to include an outer portion, an inner portion, and a first shock absorbing portion;
the outer portion is positioned to define an outer wall of the rocker panel in the vehicle width direction;
the inner portion is formed integrally with the outer portion, is positioned inward of the outer portion in the vehicle width direction, and forms a closed sectional portion with the outer portion;
the first shock absorbing portion extends in the vehicle width direction from the outer portion to the inner portion in the closed sectional portion and is disposed to overlap the electric power supply device in vehicle side view
the electric power supply device is a storage battery;
the storage battery is provided with a battery case accommodating a plurality of battery modules;
a first cross member extending along the vehicle width direction is disposed to overlap the first shock absorbing portion in vehicle side view in the battery case;
the first shock absorbing portion is configured to include a first lateral wall extending in the vehicle width direction; and
the first cross member is configured to include a second lateral wall overlapping the first lateral wall extending in the vehicle width direction in vehicle side view.

US Pat. No. 10,710,039

DEVICE AND METHOD FOR LOADING PELLETS

Tubemaster, Inc., Louisv...

1. A method for loading porous pellets, comprising the steps of:providing a tubular member defining a bottom opening, a top opening, and a fluid flow path from said bottom opening to said top opening, with a screen across said fluid flow path which is sized with a small enough mesh to prevent a desired size of porous pellets from passing through said screen while allowing smaller-sized dust to pass through, wherein a lower portion of said tubular member below said screen defines a desired volume;
providing a vacuum line in fluid communication with said top opening of said tubular member;
creating an air flow along said fluid flow path and through said vacuum line, with a desired volume of porous pellets in said lower portion of said tubular member;
moving said tubular member to a position over a desired loading location; and then
reducing said upward flow of air sufficiently to allow said desired volume of porous pellets to fall down, through said lower portion of said tubular member.

US Pat. No. 10,710,037

CHEMICAL MIXING SYSTEM AND METHOD

DuBois Chemicals, Inc., ...

1. A method for mixing a concentrated liquid chemical detergent solution for use with a car wash application-level delivery system, comprising:receiving a base fluid into a mixing station having an injector assembly that includes at least one venturi chamber having at least one suction port in fluid communication with the at least one venturi chamber;
regulating the pressure of the base fluid to less than 40 psi;
providing a source of at least one super concentrate liquid chemical detergent component in fluid communication with the injector assembly via a first tube;
providing a receiving container for collection of a final concentrated liquid chemical detergent solution that is in fluid communication with the injector assembly via a second tube;
mixing the at least one super concentrate liquid chemical detergent component with the base fluid in the at least one venturi chamber to create a concentrated liquid chemical detergent solution, wherein a flow of the base fluid through the at least one venturi chamber of the injector assembly draws the at least one super concentrate liquid chemical detergent component through the at least one suction port and into the flow of the base fluid; and
dispensing the concentrated liquid chemical detergent solution into the receiving container, wherein the dispensed concentrated liquid chemical detergent solution is suitable for use with the car wash application-level delivery system to produce an application-level dilution of the chemical detergent component.

US Pat. No. 10,710,031

BEVERAGE DISPENSER SYSTEM WITH INTEGRATED CARBONATOR

The Coca-Cola Company, A...

1. A chilling reservoir for a beverage dispenser; the chilling reservoir comprising:a housing defining a first beverage material pathway extending therethrough, the first beverage material pathway having a flow inlet arrangement and a flow outlet arrangement wherein the first beverage material pathway is a coil formed of stainless steel tubing;
a heat exchanger arrangement that is positioned and configured to be operated to chill beverage material passing through the first beverage material pathway; and
a carbonation chamber including an outer shell, the outer shell of the carbonation chamber being operably positioned in the first beverage material pathway of the housing, the outer shell of the carbonation chamber being configured to removably receive therein a carbonator;
wherein the chilling reservoir is a cold plate that is formed as a cast metal around the stainless steel tubing.

US Pat. No. 10,710,025

INORGANIC FIBROUS MEMBRANE AND A METHOD OF FABRICATING THEREOF

NANYANG TECHNOLOGICAL UNI...

1. A method of fabricating a non-calcined inorganic fibrous membrane, the method comprising the steps of:providing sulfonated graphene oxide in a dispersion;
grafting the sulfonated graphene oxide to inorganic nanofibers by adding the inorganic nanofibers to the dispersion and forming a suspension of heterojunctions, wherein the inorganic nanofibers are selected from the group consisting of: cryptomelane manganese oxide nanowires, TiO2 nanofibers, MnO2 nanofibers, SnO2 nanowires, SrTiO3 nanofibers, and Fe3O4 nanofibers;
filtering the suspension through a support to obtain a cake layer of the heterojunctions on the support;
drying the cake layer on the support at a non-calcining temperature to provide a non-calcined inorganic fibrous membrane on the support; and
removing the non-calcined inorganic fibrous membrane from the support.

US Pat. No. 10,709,566

IMPLANT AND METHOD FOR ANKLE SYNDESMOSIS TREATMENT

WRIGHT MEDICAL TECHNOLOGY...

1. An implant, comprising:a curved first plate section having a curvature about a longitudinal axis extending in a longitudinal direction, the curved first plate section having a first hole and a second hole, the first hole positioned to receive a first bone screw and the second hole positioned to receive a second bone screw for attaching the implant to a first curved surface of a bone having a syndesmosis;
a second plate section extending continuously from the curved first plate section, the second plate section having at least a third hole that is positioned to be offset in a direction anterior or posterior from the first hole and the second hole in a case where the longitudinal axis is aligned along a superior-inferior direction, the third hole configured to receive at least one button, wherein the at least one button is configured to hold a suture at a position offset from the first hole and the second hole in the anterior or posterior direction, wherein the suture is configured to reduce the syndesmosis, and wherein the third hole is configured to receive the suture parallel to a tibial plafond in a coronal plane such that a force vector is approximately along a line segment connecting an area centroid of a tibia with an area centroid of the fibula; and
wherein the third hole is offset from the first hole and the second hole by an angle in range from 25 degrees to 35 degrees.

US Pat. No. 10,709,359

SYSTEMS AND METHODS FOR DYNAMICALLY IDENTIFYING A PATIENT SUPPORT SURFACE AND PATIENT MONITORING

CareView Communications, ...

11. A method for processing a chronological series of frames containing three dimensional pixel information generated by a camera to monitor a patient in a patient area by performing the following steps, each step performed at least in part by a computing system:receiving the three dimensional pixel information of the plurality of frames;
identifying a location and dimensions of a patient support surface based on the three dimensional pixel information;
setting at least one threshold that is extended above, below, or vertically beyond the location and dimensions of the patient support surface;
determining a repositioning of the patient support surface;
adjusting the at least one threshold based on the repositioning of the patient support surface;
identifying one or more patient locations based on the three dimensional pixel information;
comparing the one or more patient locations to the at least one threshold; and
generating an output with the user interface based on the one or more patient locations traversing the at least one threshold.
US Pat. No. 10,709,742

METHOD TO AMPLIFY CARDIAC STEM CELLS IN VITRO AND IN VIVO

VESTION, INC., Miami, FL...

1. A pharmaceutical composition for treating heart disease comprising mesenchymal stem cells and c-kit+ cardiac stem cells and a pharmaceutically acceptable carrier.
US Pat. No. 10,711,050

VARIANT SERUM ALBUMIN WITH IMPROVED HALF-LIFE AND OTHER PROPERTIES

ALBUMEDIX LTD, Nottingha...

1. A method of making a variant serum albumin polypeptide (VSA) having an altered binding affinity to FcRn as compared with the binding affinity of a wild type human serum albumin (HSA) to FcRn comprising:providing a nucleic acid encoding a variant serum albumin polypeptide (VSA) comprising a sequence that has a substitution to A at a position corresponding to position 547 of SEQ ID NO: 2, a substitution to G at a position corresponding to position 505 of SEQ ID NO: 2, and is at least 90% identical but less than 100% identical to amino acid residues 380 to 585 of SEQ ID NO: 2;
introducing the nucleic acid encoding the VSA in a suitable host cell;
culturing the host cell under conditions that allow expression of the polypeptide; and
isolating the polypeptide from the host cell or from the host cell growth medium,
wherein the VSA binds to FcRn with a higher affinity as compared to the binding affinity of HSA to FcRn.

US Pat. No. 10,715,760

DISPLAY SYSTEM, DISPLAY METHOD, AND DISPLAY APPARATUS

Panasonic Intellectual Pr...

1. A display apparatus comprising:an electro-optical transfer function (EOTF) converter that receives a video signal having a first luminance range and performs EOTF conversion on the video signal to obtain a first luminance value;
a luminance converter, which is provided for converting the video signal into a pseudo High Dynamic Range signal having a second luminance range, a maximum value of the second luminance range being smaller than a maximum value of the first luminance range, the luminance converter that converts the first luminance value into a second luminance value within the second luminance range, the maximum value of the second luminance range being larger than a maximum value of a luminance of a Standard Dynamic Range (SDR) signal, and the maximum luminance value of the SDR signal being 100 nit; and
a display that displays the pseudo High Dynamic Range signal having the second luminance range based on the second luminance value,
wherein the maximum value of the second luminance range is a maximum possible display peak luminance (DPL) that the display is capable of displaying, and is greater than the maximum luminance value of the SDR signal, and
wherein the luminance converter performs conversion of the first luminance value into the second luminance value, based on content luminance information of the video signal.

US Pat. No. 10,714,848

ELECTRICAL HIGH-CURRENT CONNECTOR AND METHOD FOR PRODUCING AN ELECTRICAL HIGH-CURRENT CONNECTOR

TE Connectivity Germany G...

1. An electrical connector assembly for an accumulator or a battery, comprising:an electrical connector including a stranded wire having a longitudinal end section and a connecting piece, the longitudinal end section of the stranded wire is incorporated in a material of the connecting piece;
a jacket electrically insulating a central region of the electrical connector; and
a capsule electrically insulating a longitudinal end region of the electrical connector, the capsule including a pair of insulating shells attachable to one another.

US Pat. No. 10,713,357

DETECTING LATERAL MOVEMENT USING A HYPERVISOR

NICIRA, INC., Palo Alto,...

1. A system for hypervisor detection of attempted arbitrary code execution in zero-day exploits, said system comprising:at least one physical processor; and
at least one memory comprising computer program code, the at least one memory and the computer program code configured to, with the at least one physical processor, cause the physical processor to at least:
detect, by a hypervisor via a hidden breakpoint, a request from a current process in a guest operating system (OS) to create a thread, the request including a process identifier (ID) for the thread;
in response to detecting the request, determine whether a process ID for the current process is different from the process ID for the thread and different from a process ID for a parent process of the thread; and
upon determining that the process ID for the current process is different from the process ID for the thread and different from the process ID for the parent process of the thread:
obtain a thread context for the thread and a process context for the current process, the thread context identifying an entry point for the thread, the process context identifying a set of modules associated with the current process; and
upon the entry point being outside an address space of the identified set of modules or associated with a function that loads other code, classify the request as attempted lateral movement associated with malware.

US Pat. No. 10,712,339

ENGINEERING OF A NOVEL BREAST TUMOR MICROENVIRONMENT ON A MICROFLUIDIC CHIP

Arizona Board of Regents ...

1. A microfluidic device, comprising:a surface defining one or more microfluidic channels, wherein the surface extends beyond the one or more microfluidic channels;
a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels;
a second three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the first three dimensional scaffold, and that is spatially separated from the one or more microfluidic channels; and
a third three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the one or more microfluidic channels and the second three dimensional scaffold, wherein the extended surface underlies the first, second and third three dimensional scaffolds.

US Pat. No. 10,712,306

SENSOR FOR DETECTION OF ACETONE

The Florida International...

17. A sensor device, comprising:a substrate;
a micro-fuel cell sensor disposed on a first surface of the substrate;
at least one humidity sensor disposed on the substrate; and
at least one thermocouple disposed on the substrate,
the first surface of the substrate having a surface area of 81 square millimeters (mm2) or less,
the sensor device further comprising a processor and a machine readable medium comprising instructions stored thereon that, when executed by the processor, perform a multivariate statistical technique on data obtained from the micro-fuel sensor,
the multivariate statistical technique being principle component analysis (PCA),
the performing of the PCA comprising:
(i) standardizing the data;
(ii) obtaining eigenvectors and eigenvalues (d) from a covariance or correlation matrix of the data;
(iii) sorting the eigenvalues in descending order and choosing the eigenvectors that correspond to the k largest eigenvalues, where k is the number of dimensions of a new feature subspace (k?d);
iv) multiplying the received data and the eigenvectors to obtain a new data set;
v) re-orientating the new data set onto new axes of a plot to obtain a re-oriented data set; and
vi) plotting the re-oriented data set on the plot,
each thermocouple of the at least one thermocouple comprising a U-shape structure with a first side formed of chromium and a second side formed of aluminum,
each humidity sensor of the at least one humidity sensor comprising interdigitated electrodes formed of gold,
the micro-fuel cell sensor comprising a working electrode, a reference electrode, a counter electrode, and a proton exchange membrane (PEM),
the at least one humidity sensor comprising a first humidity sensor formed at a first corner on the first surface of the substrate and a second humidity sensor formed at a second corner on the first surface of the substrate,
the at least one thermocouple comprising a first thermocouple formed at a third corner on the first surface of the substrate and a second thermocouple formed at a fourth corner on the first surface of the substrate, and
the micro-fuel cell sensor being disposed on a central region of the first surface of the substrate.

US Pat. No. 10,711,894

VEHICLE AND ELECTRIC POWER TRANSMISSION SYSTEM

Toyota Jidosha Kabushiki ...

1. A vehicle equipped with a power receiving device that is configured to receive electric power contactlessly from a power feeding device that is located outside the vehicle, the vehicle comprising:a power receiving part configured to receive electric power contactlessly from a power feeding part of the power feeding device;
a communication part configured to communicate with the power feeding device;
an operating part configured to allow a driver to select a parking lock state where rotation of an axle is locked or a non-parking lock state where the parking lock state is cancelled;
a parking lock device configured to be mechanically switchable between the parking lock state and the non-parking lock state; and
a controller configured to control the parking lock device according to an electric signal that is output from the operating part,
wherein, while the power receiving part is receiving electric power with the parking lock device being in the parking lock state, the controller
sends a first command that commands stop of power feeding to the power receiving device to the power feeding device via the communication part when the non-parking lock state is selected by the operating part, and
controls the parking lock device so that the parking lock device is switched from the parking lock state to the non-parking lock state after electric power that is being transmitted from the power feeding device to the power receiving device has decreased to a predetermined value or lower.

US Pat. No. 10,711,889

METHOD OF OPERATING A VEHICLE AND A VEHICLE

8. A method of operating a vehicle,the vehicle comprising:
an engine;
an engine coolant temperature sensor sensing an engine coolant temperature;
a throttle operator being operable by a driver of the vehicle;
a throttle valve regulating airflow to the engine, a throttle valve position of the throttle valve being based at least in part on a throttle operator position of the throttle operator;
a continuously variable transmission (CVT) operatively connected to the engine, the CVT including a driving pulley, a driven pulley, and a belt operatively connecting the driving pulley to the driven pulley;
at least one ground engaging member operatively connected to the driven pulley and comprising at least one of: a wheel and a track;
a piston operatively connected to the driving pulley for applying a piston force to the driving pulley when actuated and thereby changing an effective diameter of the driving pulley; and
a control unit for controlling actuation of the piston and the piston force, the method comprising:
determining at least one of the throttle operator position and the throttle valve position;
determining the engine coolant temperature;
detecting a parking/drive away condition indicative of one of a parking operation and a drive-away operation of the vehicle;
responsive to the detection of the parking/drive away condition, actuating the piston and controlling the piston force based on the at least one of the throttle operator position and the throttle valve position; and
controlling the piston force based on the engine coolant temperature.

US Pat. No. 10,711,372

SILICON CARBIDE EPITAXIAL WAFER MANUFACTURING METHOD, SILICON CARBIDE SEMICONDUCTOR DEVICE MANUFACTURING METHOD AND SILICON CARBIDE EPITAXIAL WAFER MANUFACTURING APPARATUS

Mitsubishi Electric Corpo...

1. A silicon carbide epitaxial wafer manufacturing apparatus comprising:a growth furnace performing epitaxial growth;
a first gas introduction port provided on a first side of the growth furnace and leading into the growth furnace a process gas for growing a silicon carbide epitaxial layer;
a second gas introduction port provided on the first side of the growth furnace and leading into the growth furnace a stabilization gas for nitriding, oxidizing or oxynitriding and stabilizing silicon carbide attached to an inner wall surface of the growth furnace;
a wafer holder having a mount surface on which a wafer is mounted;
a first gas exhaust port provided on a second side of the growth furnace that is opposite to the first side, the first gas exhaust port for exhausting the process gas; and
a plurality of second gas exhaust ports provided lower than the wafer holder and for exhausting the stabilization gas.

US Pat. No. 10,710,993

BENZOFURAN PYRAZOLE AMINE KINASE INHIBITOR

HANGZHOU REX PHARMACEUTIC...

1. A compound having the following general structural formula (I) or a pharmaceutically acceptable salt thereof:
Wherein R1 is selected from

R0, R8 and R9 are each independently selected from one or more of the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, acyl, amido, sulfo group, sulfanilamido, hydroxyl, aryl and heterocyclyl;
R2, R3, R4, R5, R6, R7, R10 and R11 are each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, cyano and amino;
R13 is selected from one or more of the group consisting of hydrogen, C1-6 alkoxy, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, amido, boryl, amino, hydroxyl, cyano, carbonyl, carboxy, aryl and heterocyclyl;
R12 and R14 are each independently selected from one or more of the group consisting of hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C3-6 cycloalkyl, amino, amido, hydroxyl, carbonyl, ureido, sulfuryl, sulfamido, phosphoroso, boryl, aryl and heterocyclyl;
R10 and R11 each substitute at the pyrimidine of the parent nucleus, or R10 and R11 are linked to each other to form a 5-7 membered saturated or unsaturated carbocyclic or heterocyclic ring fused with the pyrimidine of the parent nucleus;
the heterocyclyl is a 3-12 membered heterocyclic ring containing one or more of N and O atoms;
m is selected from any integer from 0 to 3; p is selected from any integer from 0 to 6; andn is 1 or 2.

US Pat. No. 10,710,987

HYDROCHLORIDE SALT FORM FOR EZH2 INHIBITION

Epizyme, Inc., Cambridge...

1. A method of preparing a solid crystalline form of a N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide monohydrochloride, wherein the solid crystalline form exhibits an X-ray powder diffraction pattern having two or more peaks expressed in degrees 2-theta (+/?0.2), selected from the group consisting of 8.438, 10.083, 10.18, 10.74, 10.940, 11.22, 12.0, 13.116, 13.318, 13.418, 13.541, 13.762, 13.899, 16.443, 16.583, 17.026, 17.124, 17.219, 17.53, 17.78, 18.032, 18.32, 18.340, 18.419, 18.66, 19.399, 20.182, 20.199, 20.421, 20.500, 20.839, 21.14, 21.84, 21.917, 21.958, 22.22, 22.499, 23.238, 23.46, 23.725, 24.159, 24.363, 24.7, 24.958, 25.498, 26.222, 26.596, 26.863, 27.72, 30.30, 30.557, and 30.879, comprising the step of combining N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide with hydrochloric acid.

US Pat. No. 10,710,792

AEROSOL CONTAINER WITH EASY-TO-OPERATE PUSH BUTTON

1. An aerosol container comprising:a main body filled with aerosol substance, wherein said main body is cylindrical in shape and includes a bottom end being entirely flat;
a nozzle disposed on a top end of said main body, wherein said nozzle includes a vertical portion and a horizontal portion, wherein said nozzle extends within said main body a predetermined depth and lies above said bottom end of said main body, wherein said horizontal portion is located at said top end of said vertical portion, wherein said top end of said vertical portion extends outwardly from said top end of said main body, wherein said horizontal portion forms a right angle with said vertical portion;
a pipe defined with a first end introduced in aerosol substance, a second end connected to said nozzle and a body therebetween; and
an actuating mechanism including a valve in connection with an internal body portion of said pipe, wherein said valve is actuated by a push button located on an outer surface of said main body, a rod mounted in a horizontal configuration connecting said push button and said valve, wherein said rod includes a spring mounted to an outer surface of said rod, wherein said rod and said spring are located entirely within said main body.

US Pat. No. 10,710,791

HAIR TREATMENT PROCESS THAT PROVIDES SHEEN USING AN AEROSOL DEVICE

1. A hair treatment process comprising:applying to the hair a composition comprising at least one fatty substance using an aerosol device, wherein the aerosol device comprises:
a container containing the composition and at least one propellant, wherein the at least one propellant possibly is present in the composition or in the container, separate from the composition; and
a diffuser for dispensing said composition, the diffuser comprising:
a body extending around a dispensing axis and being open at two opposite axial ends, and
an engaging part extending around the dispensing axis and being open at two opposite axial ends,
wherein the engaging part at least partially defines a dispensing orifice.

US Pat. No. 10,710,040

SYSTEMS FOR PROMOTING ENDOTHERMIC CONVERSIONS WITH OXYGEN TRANSFER AGENTS

EcoCatalytic Inc., Wobur...

1. A system for promoting endothermic conversions comprising:a) a first portion defining a first inner volume at least partially filled with an oxygen transfer agent;
b) a first supply containing one or more of hydrogen and a saturated hydrocarbon fluidly connected to a first inlet of the first inner volume;
c) a first outlet conveying one or more of carbon dioxide, water, and an unsaturated hydrocarbon from the first inner volume;
d) a second portion and a heat exchanger within the second portion, the second portion defining a second inner volume at least partially filled with reduced oxygen transfer agent, the heat exchanger defining a third inner volume segregated from the second inner volume;
e) a second supply containing an oxidizing agent fluidly connected to a second inlet to the second inner volume; and
f) a third supply fluidly connected to the third inner volume, wherein the third supply contains a saturated hydrocarbon and, optionally, water;
wherein the heat exchanger is configured to transfer heat resulting from the oxidation of the reduced oxygen transfer agent in the second inner volume to the third inner volume and the heat from the oxidation of the reduced oxygen transfer agent results in endothermic conversion of the saturated hydrocarbon in the third inner volume to an unsaturated hydrocarbon; and
wherein at least one of condition i) or condition ii) is met: i) the first supply additionally contains a sulfur containing gas; ii) the oxidizing agent is comprised of at least one oxide of sulfur.

US Pat. No. 10,710,032

UNIVERSAL BRIDGE AND WALL MOUNTED AERATION APPARATUS

Aeration Industries Inter...

1. In combination, a wall and bridge mount, a track extending between two distinct elevations and coupled to said wall and bridge mount, an aeration unit pivotally coupled to said track and having an aerator configured to operatively at least partially submerge within and aerate a liquid, and a drive configured to operatively move said aeration unit along said track and thereby vary an elevation of said aeration unit,said wall and bridge mount having:
at least one horizontal wall brace configured to affix upon the top surface of a stationary structure;
at least one vertical wall brace rigidly affixed to said at least one horizontal wall brace and that extends down therefrom, said at least one vertical wall brace configured to affix upon the vertical side of a stationary structure;
at least one lower track support bar extending horizontally from adjacent a lower end of said at least one vertical wall brace;
said track extending from said at least one lower track support bar adjacent an end of said at least one lower track support bar distal to said at least one vertical wall brace lower end and passing through a vertical plane defined by said vertical side of said stationary structure.

US Pat. No. 10,710,030

GAS SOLUTION PRODUCTION APPARATUS

EBARA CORPORATION, Tokyo...

1. A gas solution production apparatus, comprising:a gas dissolving unit that dissolves gas of a second raw material into a liquid of a first raw material to generate a liquid mixture; and
a gas-liquid separation unit that separates the liquid mixture generated by the gas dissolving unit into a gas solution that is supplied to a use point and an exhaust gas that is discharged from an exhaust port,
wherein the gas-liquid separation unit includes a capacity variable section that changes a capacity of an internal space of the gas-liquid separation unit for receipt of the liquid mixture into the internal space.

US Pat. No. 10,709,963

GAME SYSTEM AND IMAGE DISPLAY METHOD

SEGA SAMMY CREATION INC.,...

1. A game system comprising:a master control unit having a central processing unit (CPU) and memory; and
a plurality of game units, each of the plurality of game units being configured to progress a game over a plurality of rounds;
wherein the master control unit comprises:
a game progress control unit that configures the CPU to allow the plurality of game units to progress and output game result information that indicates whether a player has won, lost, or tied in each of the plurality of rounds;
a win and loss history managing unit that configures the CPU to manage a win and loss history of each of the plurality of game units by storing and updating win and loss history information stored in a win and loss history storing area corresponding to each of the plurality of game units in a memory each time when new game result information is received; and
an image generating unit that configures the CPU to read out each of the win and loss history information from the win and loss history storing area corresponding to each of the plurality of game units, generate an icon image that represents any of win, loss, or tie that the win and loss history information indicates, and generate a win and loss history image that represents the win and loss history for each of the plurality of game units by lineups of the icon images,
wherein the image generating unit further configures the CPU to determine whether the win and loss history meets a predetermined highlight condition, and to perform highlighting on the win and loss history image corresponding to the win and loss history determined to meet the highlight condition;
wherein the highlighting includes changing a display mode of a plurality of the icon images displayed at a position where the highlight condition is met;
wherein changing the display mode of the plurality of the icon images includes highlighting the plurality of icon images that match a predetermined condition to indicate reaching the predetermined condition;
wherein changing the display mode of the plurality of the icon images includes changing the plurality of icon images that have matched the predetermined condition into another image.

US Pat. No. 10,715,764

SYSTEM AND METHOD FOR SCALABLE MEDIA SWITCHING CONFERENCING

Cisco Technology, Inc., ...

1. A method comprising:obtaining, by a server from a first client device, metadata indicating different formats of video that the first client device is configured to transmit during a call connection with a second client device, wherein the first client device is establishing a connection via the server to the second client device using a call control protocol and the different formats of the video are provided in a form of a plurality of different video streams each of which has a different format for the video;
selecting, by the server, at least two of the plurality of different video streams including a first video stream having a first format and a second video stream having a second format different from the first format;
providing, by the server to the second client device, a first identifier with the first video stream, and a second identifier with the second video stream, the second identifier being different from the first identifier;
obtaining, by the server from the second client device, a first subscription message including the first identifier or the second identifier;
based on the first identifier or the second identifier obtained in the first subscription message, providing, by the server to the first client device, a message instructing to start transmission, to the second client device, of a first selected video stream from among the first video stream and the second video stream; and
obtaining, by the server from the second client device, an unsubscribe message unsubscribing to the first selected video stream, based on an event occurring during the call connection.

US Pat. No. 10,715,585

PACKET PROCESSOR IN VIRTUAL FILTERING PLATFORM

Microsoft Technology Lice...

1. A method for facilitation communication in a distributed computing system having hosts individually supporting a virtual switch and one or more virtual machines, comprising:receiving, at the virtual switch provided by a host, a packet having a header with multiple header fields and a payload; and
processing, at the virtual switch, the received packet based on multiple layer, group, and rule objects arranged in a hierarchy in which the multiple layer objects individually contain one or more group objects that individually contain one or more rule objects, each of the rule objects containing one or more conditions and a corresponding action performable by the virtual switch on the packet, wherein processing the received packet includes,
parsing one or more of the header fields of the packet;
matching the parsed one or more header fields with the conditions of one of the rule objects from the group objects of each of the layer objects;
generating a composite action having multiple actions each corresponding to a matched rule object from each of the layer objects without applying any of the multiple actions to the packet, the multiple actions being accumulative to one another; and
subsequently, applying the generated composite action to the packet.

US Pat. No. 10,713,354

METHODS AND APPARATUS TO MONITOR PERMISSION-CONTROLLED HIDDEN SENSITIVE APPLICATION BEHAVIOR AT RUN-TIME

1. An apparatus for resource access monitoring comprising:a display;
a processor coupled to the display; and
a memory coupled to the processor, the memory comprising instructions executable by the processor to:
identify an access attempt to a monitored resource by an application, the identification occurring after an access permission check is performed,
implement a monitor on a critical access path to the monitored resource, the monitor configured to identify the access attempt to the monitored resource by the application,
implement a permission monitor, the permission monitor configured to receive, via the monitor, a call reporting the access attempt to the monitored resource by the application,
authenticate the call to the permission monitor by a caller authenticator,
responsive to the caller authenticator authenticating the call to the permission monitor, determine whether the access attempt involves suspicious activity by evaluating a potential risk associated with the application accessing the monitored resource, and
in response to determining that the access attempt involves suspicious activity, provide a graphical user interface (GUI) to the display, the GUI providing a notification of the access attempt.

US Pat. No. 10,713,352

METHOD AND APPARATUS FOR TRUSTED MEASUREMENT

Huawei Technologies Co., ...

1. A method for trusted measurement, comprising:obtaining, when start-up of a system is completed, a first processing result by performing a first-manner processing on a code segment in a memory, and using a result obtained by performing a platform configuration register (PCR) extending operation on the first processing result as a first reference value, wherein the performing the first-manner processing on the code segment in the memory comprises performing a hash calculation on the code segment in the memory, and the performing the PCR extending operation on the first processing result comprises obtaining the first reference value by performing the hash calculation on the first processing result and a preset first value;
obtaining, at a first moment when the system is running, a second processing result by performing the first-manner processing on the code segment in the memory, and obtaining a first measurement value by performing the hash calculation on the second processing result and the first preset value;
determining whether the first measurement value and the first reference value are equal;
determining, when the first measurement value and the first reference value are equal, that the system is trusted, or determining, when the first measurement value and the first reference value are not equal, that the system is not trusted; and
when the first measurement value and the first reference value are equal, using a result obtained by performing the PCR extending operation on the second processing result as a first expected value, and the first expected value is used as a second reference value for a next trusted measurement when the system is still running;
wherein the code segment in the memory is a code segment that does not change with normal running of the system during one start-up and a running process of the system.

US Pat. No. 10,712,439

METHOD FOR DETERMINING A DISTANCE BETWEEN A VEHICLE AND AN IDENTIFIER

1. A method for measuring a distance separating a vehicle and an identifier for accessing and starting the vehicle, the vehicle and the identifier being synchronized, the method comprising:transmitting, from the vehicle to the identifier, a first train of N first sinusoidal signals with identical amplitudes and with regularly spaced respective frequencies fp, P?[1;N];
receiving, by the identifier, an image train of N second sinusoidal signals corresponding to the N first sinusoidal signals, wherein the N second sinusoidal signals comprise phases and amplitudes that are altered from the N first sinusoidal signals by transmission from the vehicle to the identifier;
generating, by the identifier, measurements of the phases and the amplitudes of the N second sinusoidal signals;
transmitting the measurments of the phases and the amplitudes of the N second sinusoidal signals, from the identifier to the vehicle;
transmitting, from the identifier to the vehicle, a second train of N third sinusoidal signals that are identical to the N first sinusoidal signals of the first train;
receiving, by the vehicle from the identifier, a second image train corresponding to the second train altered by transmission from the identifier to the vehicle;
constructing a frequency spectrum based on the measurements of the phases and the amplitudes transmitted to the vehicle and the second image train received by the vehicle, wherein the frequency spectrum is constructed by detecting spectral lines of the first image train and the second image train;
performing, by a computer processor, an inverse Fourier transform of the frequency spectrum to obtain a temporal signature;
determining, by the computer processor, an intermediate time associated with a maximum of the temporal signature; and
calculating by the computer processor, the distance on the basis of the intermediate time.

US Pat. No. 10,712,337

DETECTING GASES AND RESPIRATION BY THE CONDUCTIVITY OF WATER WITHIN A POROUS SUBSTRATE SENSOR

President and Fellows of ...

1. A method of detecting respiration of a patient comprising:providing a sensor comprising an electrode pair in electrical contact with a layer of hygroscopic porous cellulose paper material capable of adsorbing and desorbing water as a function of relative humidity;
positioning the sensor in the proximity of a mouth and/or nose of the patient; and
monitoring the change in water content of the sensor over time by application of a voltage across the electrode pair, such that a current is induced that is proportional to the ionic content of water in the hygroscopic porous cellulose material, and wherein the increase and decrease in water content is correlated to exhalation and inhalation, respectively.

US Pat. No. 10,711,895

CONTROL APPARATUS FOR VEHICLE TRANSMISSION

Toyota Jidosha Kabushiki ...

1. A control apparatus for a vehicle transmission that includes (i) a shaft, (ii) a plurality of transmission gears which are disposed on the shaft, (iii) a switching mechanism which is disposed to be adjacent to one of the transmission gears in an axial direction of the shaft and which is to be switched between a connecting state in which the one of the transmission gears is rotatable integrally with the shaft and a disconnecting state in which the one of the transmission gears is rotatable relative to the shaft, (iv) a shift fork which is configured to move the switching mechanism in the axial direction and (v) a shift barrel that is to be rotated to position the shift fork in a position that is dependent on a rotation angle of the shift barrel, in the axial direction,wherein the switching mechanism includes (iii-1) first and second rings which are disposed on the shaft so as to be arranged in the axial direction and which are unrotatable relative to the shaft and movable relative to the shaft in the axial direction and (iii-2) an elastic member which is disposed between the first and second rings in the axial direction and connects the first and second rings, and
wherein said control apparatus comprises a failure determining portion configured to determine that a failure occurs in the vehicle transmission, when a reaction-force-related value related to a reaction force that acts on the shift barrel during rotation of the shift barrel is deviated from a predetermined range.

US Pat. No. 10,711,892

GEARBOX FOR A MOTOR VEHICLE

1. A gearbox for a motor vehicle including a plurality of forward gear ratios and a reverse gear ratio, the gearbox further including:a control device configured for controlling the selection and the engagement of said forward gear ratios and of said reverse gear ratio; and
a plurality of engagement devices that can be controlled by means of said control device for engaging the forward gear ratios or reverse gear ratio of the gearbox that are operatively associated to said devices,
wherein the gearbox includes a locking device, which is electrically controlled and configured for preventing actuation of the engagement device associated to a predetermined forward gear ratio, said locking device being configured for being actuated above a threshold speed of a motor vehicle on which said gearbox is installed,
wherein said predetermined forward gear ratio includes a first gear ratio,
wherein said locking device includes at least one actuator configured for displacing a pin between an extracted position and a retracted position,
wherein said control device includes a case fixed to a casing of said gearbox and a control shaft rotatably mounted and axially movable within said case,
said control shaft comprising a first radial engagement finger and a second radial engagement finger for controlling corresponding devices for engagement of the forward gear ratios and of the reverse gear ratio, and
said locking device comprising a bushing connected in rotation to said control shaft and axially movable with respect thereto, said bushing being countered in the axial movement of the control shaft by an elastic element, said at least one actuator of said locking device including at least one electromagnetic actuator fixed to said case.

US Pat. No. 10,711,005

COMPOUND I AND COMPOUND II AS WELL AS PREPARATION METHODS THEREFOR AND APPLICATION THEREOF

SHENZHEN UNIVERSITY, She...

1. A compound of formula I:

US Pat. No. 10,710,990

METHOD FOR PRODUCING GLYCERIC ACID ESTER

KAO CORPORATION, Tokyo (...

1. A method of producing a compound represented by the following formula (II), comprising a step of oxidatively esterifying Compound A, Compound A being represented by the following formula (I), with Compound B, Compound B being selected from an organic nitroxyl radical, an N-hydroxy form thereof, and a salt containing an oxo ammonium cation of them, and an oxidizing agent, and in the presence of a pyridine having an alkyl substituent, wherein the molar ratio of Compound B to Compound A (B:A) used in the oxidative esterification is in the range from 0.0001:1 through 0.1:1:
wherein, in the formula (I), R1 and R2 each independently represent a hydrogen atom or a monovalent hydrocarbon group, or R1 and R2 are bonded to each other to form a divalent hydrocarbon group for constituting a ring structure; and

wherein, in the formula (II), R1 and R2 each independently represent a hydrogen atom or a monovalent hydrocarbon group, or R1 and R2 are bonded to each other to form a divalent hydrocarbon group for constituting a ring structure.

US Pat. No. 10,710,986

PD-1/PD-L1 INHIBITORS

Gilead Sciences, Inc., F...

1. A compound which is:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,710,984

N-[(PYRIMIDINYLAMINO)PROPANYL]-AND N-[(PYRIDINYLAMINO)-PROPANYL]ARYLCARBOXAMIDES

Boehringer Ingelheim Inte...

1. A compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.