1. A method for treating a human diffuse large B-cell lymphoma (DLBCL) patient comprising:(a) obtaining a first biological sample from a lymph-node biopsy of a human DLBCL patient;
(b) determining the nucleic acid expression levels of
(i) all genes from the group consisting of C10orf54, C1RL, C20orf112, C8orf4, CCDC88C, CILP, CIRH1A, CLU, CPVL, CSF1R, CTSB, EPB41L3, FBXO32, IFI44, LRP11, MEGF6, MEIS1, PHACTR2, PLAT, SERPING1, SPC25, THEMIS2, TPSAB1, ULK1, XAF1, and ZNF215;
(ii) all genes from the group consisting of ANXA4, BACH2, BIN2, C7orf10, CXCL14, DAPL1, FBXO32, FCGR1B, FTX, GIMAP6, IL18BP, KCNMB1, KIAA1671, LOC284837, MPP6, MZT1, NFIC, ODF3B, OLFM1, PPAT, RFESD, RPL22L1, SERPING1, TNC, TNFRSF17, and ZNF506; or
(iii) all genes from the group consisting of BMS1P20, MZB1, TNFRSF17, FKBP11, IGLV1-44, MS4A1, BCL11A, MACROD2, FAM129C, ALDH2, KIAA1598, TGFBI, TYMP, SAMD4A, GPX3, A2M, CFB, FSTL1, SLC27A3, and NRP1;
(c) classifying the patient as a responsive patient to the treatment of a drug using the nucleic acid expression levels determined in step (b) as compared to nucleic acid expression levels of the same genes in DLBCL patients whose responsiveness to the drug is known;
wherein the drug is 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (lenalidomide); 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione (Compound A); or a stereoisomer thereof; or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate thereof; or a polymorph thereof;
(d) administering the drug to the responsive patient to the treatment of the drug as classified in step (c).