US Pat. No. 10,478,424

[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS

Bristol-Myers Squibb Comp...

14. A method of treating an autoimmune disease or a chronic inflammatory disease, comprising administering to a mammalian patient a compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein said autoimmune disease or chronic inflammatory disease is systemic lupus erythematosus.

US Pat. No. 10,478,423

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS

NERVIANO MEDICAL SCIENCES...

1. A compound of formula (I):
wherein:
Ar is a group selected from

wherein:
R1 is A, NR6R7, OR8, SOnR9, COR10, nitro, cyano or an optionally substituted group selected from C3-C6 cycloalkyl and heteroaryl;
R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, SOnR9, COR10, NR11R12, OR13 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl and heterocyclyl wherein:
A is a straight or branched C1-C6 alkyl substituted with a group selected from an optionally substituted heterocyclyl, an optionally substituted heteroaryl, SOnR9, COR10, NR11R12 and OR13;
R6 is hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl;
R7 is hydrogen, SOnR9, COR10, a substituted straight or branched C1-C6 alkyl or an optionally substituted group selected from straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl or
R6 and R7, taken together with the nitrogen atom to which they are bound, may form an optionally substituted heterocyclyl group;
R8 is hydrogen, A, COR10 or an optionally substituted group selected from straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein A is as defined above;
R9 is NR11R12 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl;
R10 is hydrogen, NR11R12, OR13 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl;
R11 and R12 are independently hydrogen, SOnR9, COR10 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein R9 and R10 are as defined above, or
R11 and R12, taken together with the nitrogen atom to which they are bound, may form an optionally substituted heterocyclyl group;
R13 is hydrogen, COR10 or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein R10 is as defined above;
n is 0, 1 or 2;
X is an optionally substituted straight or branched C1-C6 alkyl;
Y is oxygen;
Z is an optionally substituted straight or branched C1-C6 alkyl;
Ar? is an optionally substituted aryl or an optionally substituted heteroaryl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,478,421

SORTILIN BINDING COMPOUNDS, FORMULATIONS, AND USES THEREOF

University of Florida, T...

1. A method comprising:administering an amount of a compound according to Formula 2A

or a pharmaceutical formulation thereof and an amount of compound 541

or a pharmaceutical formulation thereof to a subject.

US Pat. No. 10,478,415

KETONE BODIES TO PROTECT TISSUES FROM DAMAGE BY IONIZING RADIATION

TDELTAS LIMITED, Thame O...

1. A method of protecting animal tissue from damage caused by radiation exposure, comprising contacting the tissue of a subject in need thereof with a therapeutically effective amount of an agent, wherein the agent is:
wherein n and m are 3; or

wherein n is 3;
thereby protecting the tissue from radiation damage.

US Pat. No. 10,478,412

GABA CONJUGATES AND METHODS OF USE THEREOF

Xgene Pharmaceutical Inc....

1. A compound comprising a first moiety, a second moiety and a linker which covalently links the first moiety to the second moiety, wherein the first moiety is covalently linked via an amino terminus to the linker, and wherein:the first moiety is baclofen, vigabatrin, gabapentin, or pregabalin;
the second moiety is a nonsteroidal anti-inflammatory drug (NSAID) selected from the group consisting of fenoprofen, flurbiprofen, ibuprofen, ketoprofen, and naproxen; and
the linker has a structure selected from the group consisting of:

wherein R6 and R7 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl, substituted alkoxycarbonyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, carbamoyl, cycloalkyl, substituted cycloalkyl, cycloalkoxycarbonyl, substituted cycloalkoxycarbonyl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl.

US Pat. No. 10,478,406

HIGH-PH SOLID-STATE EPINEPHRINE FORMULATION

HARC Therapeutics AG, Zu...

1. A process for manufacturing a solid-state epinephrine pharmaceutical dosage form, the process comprising: mixing epinephrine in an aqueous solvent and at least one basic-pH excipient to produce a mixture having a pH of about 8.5, whereby the epinephrine remains in solid state,wherein the mixture comprises an antioxidant and a chelating agent,
wherein the process comprises the step of removing the aqueous solvent to produce a dry dosage form, and
wherein the dry dosage form is a tablet.

US Pat. No. 10,478,405

METHOD FOR TREATING POST-TRAUMATIC STRESS DISORDER

Icahn School of Medicine ...

1. A method of treating post-traumatic stress disorder (PTSD) in a patient determined to be suffering from PTSD, comprising conducting a psychiatric evaluation of a patient to determine if the patient is afflicted with PTSD, and intranasally administering to a patient determined to be suffering from PTSD multiple sub-analgesic therapeutic doses of ketamine of between about 0.01 to about 3.0 mg of ketamine per kilogram of body weight of the patient (mg/kg).

US Pat. No. 10,478,403

INTRAOPERATIVE TOPICALLY-APPLIED NON-IMPLANTABLE RAPID RELEASE PATCH

Privo Technologies, Inc.,...

1. A device for rapid delivery of a therapeutic agent to a surgical cavity, the device comprising:a porous, mucoadhesive, freeze-dried polymeric matrix having first and second opposed surfaces, the matrix formed by a composition comprising chitosan, and a particle adhesion inhibitor, comprising hydroxypropylmethylcellulose (HPMC);
a plurality of particles, having an average diameter between 500 nm and 2000 nm, embedded within the matrix so as to be directly surrounded by, and in contact with, the matrix, the particles containing the therapeutic agent and having a coating around the therapeutic agent, the coating comprising chitosan so as to provide controlled release of the therapeutic agent from the particles through the first opposed surface of the matrix; and
one or more additives selected from the group consisting of a hydration promoter, a particle aggregation inhibitor, and combinations thereof,
wherein:
the first surface of the matrix is configured to be applied to the surgical cavity;
the device is configured to provide release of the particles through the first surface;
the device is sterilized;
the device provides release of approximately 20% to 100% of the therapeutic agent within 20 minutes of application to the surgical cavity, and
the particle adhesion inhibitor, and, when present, the hydration promoter, and the particle aggregation inhibitor are compounds mutually distinct from one another and present in amounts sufficient to achieve the controlled release of the particles without preventing formation of the freeze-dried matrix.

US Pat. No. 10,478,400

IMMEDIATE-RELEASE TABLETS CONTAINING COMBIMETINIB AND METHODS OF MAKING AND USING THE SAME

Genentech, Inc., South S...

1. A process for preparing a pharmaceutical dosage unit tablet core, the process comprising:(1) blending a particulate pharmaceutical active drug, an intragranular filler, an intragranular disintegrant and an intragranular lubricant to form a pre-blend, wherein the particulate pharmaceutical drug active has a particle size D[v, 0.5] of from about 25 ?m to about 65 ?m, from about 25 ?m to about 50 ?m, or from about 30 ?m to about 40 ?m;
(2) compacting the pre-blend by application of a compaction force of from about 1 kN/cm to about 8 kN/cm, from about 2 kN/cm to about 5 kN/cm, or from about 2 kN/cm to about 4 kN/cm;
(3) milling and screening the compacted pre-blend to form granules; and
(4) tableting the granules by application of a tableting compression force of from about 5 kN to about 20 kN, from about 14 kN to about 19 kN, from about 14 kN to about 18 kN, or from about 8 kN to about 13 kN to form the pharmaceutical dosage unit tablet core, wherein the particulate pharmaceutical active drug is cobimetinib hemifumarate polymorph Form A.

US Pat. No. 10,478,389

HAIR-DYE COMPOSITION

KAO CORPORATION, Tokyo (...

1. A hair dye composition comprising the following components (A) and (B), wherein a mass ratio of a component (B) to a component (A), (B)/(A), in a whole composition is 1 to 60 and pH (25° C.) during application is 7.5 to 12:(A): one or more azo dyes selected from the group consisting of the following (A-1), (A-2) and (A-3):

(B): at least one member selected from the group consisting of guanidine carbonate, guanidine hydrogen carbonate, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate and lithium carbonate.

US Pat. No. 10,478,388

SKIN ENGAGING SHAVING AID MEMBER COMPRISING AT LEAST ONE THERMALLY RESILIENT SENSATE

The Gillette Company LLC,...

1. A skin engaging shaving aid member, said skin engaging shaving aid member comprising:a. a matrix comprising at least one of: a water soluble polymer, an emollient, and a soap base, wherein the water soluble polymer is at a level of from about 50% to about 100%, by weight of the matrix;
b. from about 5% to about 15%, by weight of the skin engaging shaving aid member, of a thermally resilient sensate, the thermally resilient sensate comprising
N-[4-(cyanomethyl)phenyl]-(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxamide of formula:
andc. from about 15% to about 35%, by weight of the skin engaging shaving aid member, of a water insoluble polymer.

US Pat. No. 10,478,387

COATING OF CLAY MICRO-TUBES ON SURFACES OF HAIR AND NATURAL FIBERS

Louisiana Tech Research C...

1. A biocide mixture for hair comprising:(a) a carrier liquid;
(b) alumino-silicate micro-tubes having a biocide loaded into a lumen of the micro-tubes;
(c) wherein the micro-tubes are present in the carrier liquid in a concentration of between about 3 mg/ml and about 100 mg/ml; and
(d) wherein the mixture has a pH of between about 3.5 and about 7.5.

US Pat. No. 10,478,380

GLASS CONTAINERS WITH IMPROVED STRENGTH AND IMPROVED DAMAGE TOLERANCE

CORNING INCORPORATED, Co...

1. A coated glass container comprising:a borosilicate glass body having a Type 1 chemical durability according to USP 660 (2011), at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween, wherein the glass body forms the interior surface of the coated glass container and wherein the coated glass container does not comprise a boron-rich layer on the interior surface of the glass body;
a lubricous coating having a thickness of less than 100 microns positioned on at least a portion of the exterior surface, wherein:
the portion of the exterior surface of the coated glass container with the lubricous coating has a coefficient of friction that is at least 20% less than an uncoated glass container formed from the same glass composition and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle at a temperature of about 260° C. for 30 minutes and abrasion under a 30 N load;
the lubricous coating can be pyrolized at temperatures less than or equal to 300° C. in a time period of less than or equal to 1 hour;
a horizontal compression strength of the coated glass container is at least 10% greater than an uncoated glass container formed from the same glass composition and the horizontal compression strength is not reduced by more than 20% after undergoing a heat treatment at a temperature of about 260° C. for a period of time of 30 minutes and abrasion under a 30 N load;
the lubricous coating is a polymer; and
a surface region extending over the inner surface and having a persistent surface homogeneity such that the glass body is resistant to delamination such that for a discrete point on the inner surface of the glass body, an extrema of a surface concentration of each constituent component of the glass composition in the surface region at the discrete point is greater than or equal to about 70% and less than or equal to about 130% of the same constituent component in the surface region at any second discrete point on the inner surface of the glass body when the glass body is in an as-formed condition.

US Pat. No. 10,478,379

BIOLOGICAL SAMPLE CONTAINMENT SYSTEM AND LABEL

Becton, Dickinson and Com...

1. A biological sample containment system, comprising:a container for containing a biological sample, the container having a top and a bottom disposed opposite the top; and
a label capable of being affixed to the container, the label comprising:
a first side;
a second side, the label affixable to the container by the second side, the second side includes a first readable information portion comprising a fill line indicator and a second readable information portion comprising a barcode indicator above the first readable information portion;
a first top edge portion, a second bottom edge portion opposite and substantially parallel to the first top edge portion, a third edge portion, and fourth edge portion, the third and fourth edge portions each extending from the first top edge portion to the second bottom edge portion,
wherein the third edge portion and the fourth edge portion are each longer than the first top edge portion and the second bottom edge portion,
wherein the barcode indicator is disposed between the fill line indicator and the first top edge portion,
wherein the top of the container is disposed adjacent the first top edge portion,
wherein the bottom of the container is disposed adjacent the second bottom edge portion,
wherein with the label affixed to the container, at least one of the first readable information portion and the second readable information portion is readable through a portion of the container, and
wherein with the label affixed to the container and with the biological sample filled within the container to the fill line indicator, the second readable information portion is readable through a portion of the container.

US Pat. No. 10,478,378

MULTI-FUNCTIONAL ELECTRO-SPOON NEEDLE THERAPEUTIC APPARATUS

Qiang Tang, Harbin, Heil...

1. A multi-functional electro-spoon needle therapeutic apparatus, comprising a top cover, a plurality of locating pieces, two fixed lids, a rear cover, a plurality of electro-spoon needles, and an adjustment mechanism; the plurality of locating pieces being mounted on the top cover and the rear cover respectively, each of the locating pieces being provided with a long groove; the two fixed lids being fixed on the top cover and the rear cover respectively, the locating pieces being respectively held between the top cover and one of the fixed lids and between the rear cover and the other of the fixed lids; the rear cover being arranged behind the top cover and connected to the top cover through the adjustment mechanism; the electro-spoon needles being mounted in the long grooves of the locating pieces and movable along the long grooves respectively; wherein each of the electro-spoon needles includes a needle bar, an electrode member, a hollow screw, a locking nut, a silicone plug, and a cap; the electrode member is held at a bottom of the hollow screw and is in contact with the needle bar; the locking nut is screwed to the hollow screw; the silicone plug is a flexible silicone plug accommodated in the hollow screw, the silicone plug elastically holds the needle bar; the needle bar is vertically inserted through the locking nut, the silicone plug, the hollow screw and the electrode member; and the cap is disposed on a top of the needle bar.

US Pat. No. 10,478,377

PRECAST TUB

1. A precast tub comprising:at least one perimeter side wall having an interior surface, an exterior surface, a bottom edge and a top edge;
a floor extending from the bottom edge of the at least one perimeter side wall to enclose a bottom portion of the precast tub;
said at least one perimeter side wall and floor being constructed out of precast concrete;
a plumbing system encased within said concrete of said at least one perimeter side wall;
an electrical system encased within said concrete of said at least one least one perimeter side wall; and
a connection manifold located on the exterior surface of said at least one perimeter side wall wherein said plumbing system and said electrical system are connected to said connection manifold to allow said plumbing system and said electrical system to be connected to outside power sources.

US Pat. No. 10,478,376

FOOT SPA WITH ILLUMINATION

Gulfstream Inc., Cambrid...

1. An illuminated mount used in a foot spa, the foot spa having a surface defining a basin for containing water, a pump magnetically driven by rotating magnets and held against rotation by the mount which also defines part of the surface, the improvement comprising:a coil associated with the mount and disposed exteriorly of the surface of the basin and interiorly of a magnetic field produced by the rotating magnets to produce a current;
a plurality of lights operatively connected to and powered by the coil;
a plurality of platforms defined on the mount with a circuit board releasably received by one of the plurality of platforms and operatively coupling the coil to the lights;
a cover portion of the mount with a first set of receivers that engage plugs on the circuit board, and the circuit board has a second set of receivers that engage plug ends of a set of removable cords; and
wherein the mount is one of translucent or transparent to provide light conductivity to permit light from the plurality of lights to be visible interiorly of the basin.

US Pat. No. 10,478,374

SYSTEMS AND METHODS TO INCREASE SURVIVAL WITH FAVORABLE NEUROLOGICAL FUNCTION AFTER CARDIAC ARREST

ZOLL MEDICAL CORPORATION,...

1. A system for treating a patient in cardiac arrest comprising:a guidance device configured to provide feedback to a user to compress a patient's chest at a rate of between about 90 and 110 compressions per minute and at a depth of between about 4.5 centimeters per compression to about 6 centimeters per compression;
a pressure regulation system comprising a pressure-responsive valve that is adapted to be coupled to a patient's airway, wherein the pressure-responsive valve is configured to remain closed during successive chest compressions in order to permit removal of at least about 200 ml of air from the lungs, and wherein the pressure-responsive valve is configured to remain closed until the negative pressure within the patient's airway reaches about ?7 cm H2O to ?18 cm H2O, at which time the pressure-responsive valve is configured to open to provide respiratory gases to flow to the lungs through the pressure-responsive valve.

US Pat. No. 10,478,370

ACTUATED GLOVE ORTHOSIS AND RELATED METHODS

Rehabilitation Institute ...

1. An orthosis, comprising:a. a finger actuation system for a finger of a person's hand, comprising:
i. a digit having an opening to receive the finger;
ii. a cable guide connected to the digit and comprising at least one joint hyperextension mechanical stop;
iii. an actuator for applying tension on a plurality of cables;
iv. the plurality of cables inserted through the cable guide and coupled to the actuator;
v. a control system for controlling the operation of the actuator and measuring the amount of tension needed to fully extend the digit when the user is in a relaxed state;
vi. wherein the control system actuates the actuator to create a tension on the plurality of cables, which causes the cable guide to extend, in order to extend the finger;
vii. wherein in one mode of the control system, the actuator is actuated to apply a constant extension force on the plurality of cables as the finger extends from a fully flexed position to a fully extended position, the constant extension force determined by the measured tension when the user is in the relaxed state; and
vii. wherein the control system further allows voluntary finger flexion when the user exerts a voluntary flexion force that exceeds the applied extension force.

US Pat. No. 10,478,367

RECLINABLE THERAPEUTIC MASSAGE CHAIR

Ergo-Flex Technologies, L...

1. A reclinable therapeutic massage chair for use in exercising and strengthening the muscles in the back, redeveloping the muscles in the back, restoring motion to joints and alleviating soreness and stiffness in the joints and muscles of the back comprising:a floor support assembly,
a chair support frame pivotably attached to the floor support assembly,
a linear actuator extending between the floor support assembly and the chair support frame for moving the chair support frame from an inclined position to a horizontal position,
an upper back support mounted on the chair support frame and
a lower body support member having a lower back support surface, a thigh support surface and a lower leg support surface, said lower body support member being mounted for both reciprocal and oscillating movement in a same plane on the chair support frame,
the thigh support surface forming an obtuse angle with the lower back support surface and the lower leg surface is at an angle with respect to the thigh support surface, wherein the lower back support surface is located in the same plane as the upper back support, the thigh support surface and the lower leg support surface form an angle having an apex, with the apex adapted to be positioned behind a user's knee whereby when the chair is in the horizontal position, the user's thighs will be inclined upwardly toward the apex and the user's lower leg will extend downwardly from the apex.

US Pat. No. 10,478,366

ADJUSTABLE ORTHOSTATIC INTOLERANCE SYSTEM AND GARMENT

BSN Medical, Inc., Charl...

1. An adjustable orthostatic intolerance garment, comprising:(a) two leg portions and a torso portion constructed of a knitted compression fabric, the leg portions each having lateral portions configured to extend along an outer thigh and opposing medial portions configured to extend along an inner thigh and the torso portion configured to extend upwardly from the leg portions into the abdominal area and below the pectoral muscles;
(b) a pair of elongate openings, each continuously extending along the lateral portions of one of the leg portions and each defined by adjacent side edges of the fabric extending from an uppermost extent of the torso portion to a lowermost extent of a respective one of the leg portions and adapted to be releasably connected together by attachment elements continuous along an entire length of the garment extending from an outermost end portion of the torso portion of the garment to an outermost end portion of each leg portion of the garment to provide the legs and the torso with openings sized to provide a predetermined volume and an upwardly directed pressure gradient to the body of the wearer;
(c) a pair of removable elongate fabric panels adapted for insertion into a respective one of the pair of elongate openings, each fabric panel having panel side edges with complementary attachment elements continuous along an entire length of each fabric panel for being attached to the attachment elements continuous on adjacent side edges of the fabric of the elongate openings along the entire length of the torso portion and the leg portions to form the torso and leg portions with a volume that is greater than the volume provided when joined directly together, the volume comprising an upwardly directed pressure gradient configured for a wearer whose dimensional profile has changed as a result of fluid redistribution during a prolonged stay in a zero gravity environment; and
(d) a pair of knitted compression stockings adapted to extend upwardly along the legs and overlap with the lowermost extent of the leg portions for providing a pressure gradient directed upwardly from the feet of the wearer;
wherein the pair of removable elongate fabric panels when inserted into the respective one of the pair of elongate openings do not overlap the leg and torso portions;
wherein each removable elongate fabric panel includes a plurality of attachment elements, each attachment element of the plurality of attachment elements is parallel relative to one another and continuously extends on the longitudinal axis of the elongate fabric panel to selectively vary leg portion circumference of the adjustable orthostatic intolerance garment to provide the desired upwardly directed pressure gradient; and
wherein a continuous pressure gradient is highest at an ankle of the wearer and decreases progressively towards the uppermost extent of the torso portion.

US Pat. No. 10,478,364

LIMB POSITIONING SYSTEM

Stryker Corporation, Kal...

1. A limb positioning system comprising:a clamp attachable to a patient support, the clamp having first and second channels;
a first support member including first and second pylons extending outwardly from an elongate rod, the first and second pylons being receivable in the first and second channels so that the first support member is slideable relative to the clamp along a first longitudinal axis;
a second support member coupled to the first support member so that the second support member is slideable relative to the first support member along a second longitudinal axis transverse to the first longitudinal axis; and
a limb holder coupled to the second support member,
wherein the clamp includes a first wheel adjacent the first channel, and a second wheel adjacent the second channel, the first pylon includes a plurality of first notches spaced apart from one another, each first notch configured to receive the first wheel, and the second pylon includes a plurality of second notches spaced apart from one another, each second notch configured to receive the second wheel.

US Pat. No. 10,478,362

DEVICE FOR REPOSITIONING BONE FRACTURE FRAGMENTS

MAQUET GMBH, Rastatt (DE...

1. A device for repositioning bone fracture fragments, comprising:a carrier assembly;
a first arm assembly attached to the carrier assembly, the first arm assembly configured to hold a first bone fracture fragment;
a second arm assembly comprising a first end attached to the carrier assembly, and a second end extending away from the carrier assembly, the second end having a holder assembly that is configured to hold at least one Schanz screw to hold a second bone fracture fragment;
an actuator assembly configured to adjust the second arm assembly; and
an operating assembly configured to control an adjustment of the second arm assembly via the actuator assembly;
wherein the operating assembly is a manually operable operating assembly disposed in a region of the second end of the second arm assembly and configured to undergo no movement with respect to the holder assembly of the second arm assembly, or with respect to the at least one Schanz screw when present, when the second arm assembly is adjusted via the actuator assembly.

US Pat. No. 10,478,361

PERSON LIFTING DEVICES AND METHODS FOR OPERATING PERSON LIFTING DEVICES

1. A person lifting device comprising:a lift actuator operatively connected to an accessory coupling, whereby the lift actuator raises and lowers the accessory coupling;
at least one imaging sensor; and
an electronic control unit communicatively coupled to the lift actuator and the at least one imaging sensor, the electronic control unit comprising a processor and a non-transitory memory storing a computer readable and executable instruction set which, when executed by the processor:
collects, with the at least one imaging sensor, at least one image of a person to be lifted with the person lifting device;
determines, automatically with image analysis software stored on the electronic control unit and based on the at least one image, a characteristic of the person to be lifted with the person lifting device; and
determines, automatically with the electronic control unit and based on the determined characteristic, an identification of a lift accessory for attachment to the accessory coupling, wherein the characteristic comprises a weight of the person to be lifted.

US Pat. No. 10,478,360

PERSON LIFTING DEVICES WITH ACCESSORY DETECTION FEATURES AND METHODS FOR OPERATING THE SAME

1. A method for operating a person lifting device, the method comprising:detecting, with a first coupling detector, an identification of a first accessory coupling attached to a first lifting hook of a sling bar of the person lifting device;
determining, automatically with an electronic control unit communicatively coupled to the first coupling detector, a type of the first accessory coupling based on the identification of the first accessory coupling, wherein the type of the first accessory coupling is based on a predetermined attachment configuration for attaching the first accessory coupling to the sling bar;
detecting, with the first coupling detector, an identification of a second accessory coupling attached to the first lifting hook of the sling bar of the person lifting device;
determining, automatically with the electronic control unit communicatively coupled to the first coupling detector, a type of the second accessory coupling based on the identification of the second accessory coupling, wherein the type of the second accessory coupling is based on a predetermined attachment configuration for attaching the second accessory coupling to the sling bar;
comparing, with the electronic control unit communicatively coupled to the first coupling detector, the type of the first accessory coupling and the type of the second accessory coupling; and
communicating, automatically with the electronic control unit, a warning signal indicating that an accessory is improperly attached to the sling bar when the type of the first accessory coupling and the type of the second accessory coupling are different.

US Pat. No. 10,478,359

PERSON SUPPORT APPARATUSES WITH ACCELERATION DETECTION

Stryker Corporation, Kal...

1. A person support apparatus comprising:a support surface adapted to support a cushioning structure and a person thereon, the support surface including a first section and a second section, the first section being pivotable between a raised orientation and a lowered orientation;
a litter adapted to support the support surface;
a first accelerometer positioned below the first section and coupled to the litter such that the first accelerometer does not change orientation when the first section pivots; and
a controller in communication with the first accelerometer, the controller adapted to process signals from the first accelerometer to detect a presence or absence of the person on the support surface.

US Pat. No. 10,478,358

PHYSICALLY DISABLED PATIENT SUPPORT UNIT

1. A support unit for a physically disabled patient support unit comprising: a functional underwear device comprising pallets configured to be fixed to the patient after centering the anus of the patient over the device after separating the buttocks to both sides, the pallets configured to support both calves of the patient and are configured to move independently; a silicone shell casing on the device, an upper portion end part of the silicone shell casing configured to contact an area around the anus when an inclined waste pump supported by a rail mechanism located on a lower portion of the support device is lifted, the inclined waste pump being mounted inside the functional underwear device and configured to provide fluidity to wastes and ensure the descent of the wastes into a waste storage positioned below a seat portion of the support unit; an electromechanical motor which rotates a borer inside the inclined waste pump; an electromagnetic coil boated inside the rail mechanism configured to ensure a flow of the waste into the inclined waste pump in a controlled manner by rapidly controlling an opening of a slide, the slide being configured to be pulled open by the electromagnetic coil mechanism when activated by a warning of motion sensors when the motion sensors detect waste of the patient, the slide, when closed, being configured to provides a hygienic environment by closing off relationship between the patient and the waste storage; a urine removal apparatus attached to a chassis of the device and configured to be located between the legs of the patient, the urine removal apparatus containing a motion sensor and a urine area ejector, the urine area ejector configured to enable a washing and cleaning of the urine removal apparatus with a hygienic material, a tapered duct with an upper portion mounted inside the functional underwear device beneath the silicone shell casing and whose lower portion is fixed to a top cover of the slide with a ring, two sides of the tapered duct being configured with motion sensor channels, the ring being provided with a plurality of holes with different inclinations according to an inner wall of the tapered duct, the plurality of holes being configured to allow a flow of water and air from a water-air inlet opening; a moving step connected to the chassis of the support unit that is configured to be used as a step by the patient; a pipe mounted inside the moving step and configured to transfer the waste from the waste pump to a waste transfer station.

US Pat. No. 10,478,355

ABSORBENT CORE

GRUPE P.I. MABE, S.A. DE ...

1. An absorbent core for use in a disposable absorbent article having a upper surface and a lower surface, a front portion, a rear portion and a crotch portion, two longitudinal edges and two transverse edges, wherein the absorbent core is formed of three layers: an upper layer, an intermediate layer and a lower layer, such that:the upper and lower layers are comprised by a homogeneous mixture of fibers of absorbent material and particles of superabsorbent material and the particles of superabsorbent material are present in the upper and lower layers in a concentration lower than 25% by weight, wherein the upper and lower layers are not comprised 100% by fibers of absorbent material,
the intermediate layer is comprised by fibers of absorbent material homogeneously mixed with particles of superabsorbent material and has three zones with different specific weights: an acquisition-distribution zone; one or more transition zones; and one or more anti-leakage zones, in which the specific weight in g/m2 of absorbent material plus superabsorbent material of the acquisition-distribution zone of the intermediate layer is 75% to 100% greater than the specific weight in g/m2 of absorbent material plus superabsorbent material of the one or more anti-leakage zones, the specific weight in g/m2 of absorbent material plus superabsorbent material of the acquisition-distribution zone of the intermediate layer is 30 to 50% greater than an average specific weight of absorbent material plus superabsorbent material of the one or more transition zones, and the specific weight expressed in g/m2 of superabsorbent material plus absorbent material of the one or more transition zones of the intermediate layer gradually decreases towards the transverse edges of the core.

US Pat. No. 10,478,353

ABSORBENT ARTICLE HAVING A FOLDED WAIST

1. A pull-on wearable article comprising:a front region;
a back region opposite the front region;
a crotch region disposed between the front region and the back region, wherein the crotch region comprises two opposing longitudinal edges;
a chassis comprising an absorbent core extending from the front region to the back region, the absorbent core comprising a front end edge and a back end edge;
wherein the front region extends laterally outward beyond side edges of the chassis and the back region extends laterally outward beyond side edges of the chassis;
wherein the front region comprises a first front edge and a second front edge and the back region comprises a first back edge and a second back edge;
wherein a portion of the front region and a portion of the back region abut to form a first seam and a second seam such that the front region and the back region are configured to form a continuous belt, a first leg opening, and a second leg opening;
wherein at least one of the front region and the back region comprise an elastic member;
a folded continuous belt portion comprising a fold and including at least a first outer nonwoven layer of the front region and at least a second outer nonwoven layer of the back region, wherein the folded continuous belt portion extends about a circumference of the continuous belt when positioned on the wearer, and wherein the folded continuous belt portion comprises an upper edge in the front and back regions such that a distal end of each of the first outer nonwoven layer and the second outer nonwoven layer is disposed between the upper edge and the front and back end edges of the absorbent core, respectively; and
wherein the folded continuous belt comprises a first portion extending laterally between the first seam and the second seam and extending longitudinally between the upper edge and the distal end of the first outer nonwoven layer, the first portion has a first longitudinal distance measured from the upper edge to the distal end of the first outer nonwoven layer;
wherein the folded continuous belt comprises a second portion extending laterally between the first seam and the second seam and extending longitudinally between the upper edge and the distal end of the second outer nonwoven layer, the second portion has a second longitudinal distance;
wherein each of the first front edge, the second front edge, the first back edge, and the second back edge extend in a longitudinal direction perpendicular to at least one of the distal end of the first outer nonwoven layer and the distal end of the second outer nonwoven layer;
wherein the first longitudinal distance is substantially uniform relative to the second longitudinal distance;
wherein the first seam comprises discrete spaced bonds extending in the longitudinal direction from the first leg opening to the upper edge;
wherein the second seam comprises discrete spaced bonds extending in the longitudinal direction from the second leg opening to the upper edge.

US Pat. No. 10,478,350

MALE INCONTINENCE ARTICLE HAVING AN ABSORBENT CUP

KIMBERLY-CLARK WORLDWIDE,...

1. A male incontinence article comprising:a liquid permeable liner positioned to contact a male user's penis when the article is worn by the male user, the liner having a peripheral edge;
a liquid impermeable outer cover having a peripheral edge;
an absorbent core disposed between the liner and the outer cover, the absorbent core having a peripheral edge; and
a barrier positioned adjacent the peripheral edges of the liner and the outer cover, wherein the barrier is coextensive with the peripheral edges when the article is in a use configuration, the barrier including an outer surface and an inner surface, the outer surface being configured to engage the male user's skin and form a seal, wherein the barrier lies on the liner such that the entire inner surface of the barrier is in contact with the liner.

US Pat. No. 10,478,347

NOZZLE ASSEMBLY USED TO MANUFACTURE ABSORBENT ARTICLES

1. An apparatus for applying fluid to an advancing substrate, the apparatus comprising:a nozzle body comprising a first material, wherein the first material is selected from the group consisting of: an iron based alloy, an aluminum based alloy, and a titanium based alloy, and wherein the nozzle body comprises:
a passageway;
one or more abrasion resistant materials fused to the nozzle body to form a nozzle contact portion adapted to contact the advancing substrate, the one or more abrasion resistant materials comprising a first layer comprising tungsten carbide or vanadium carbide, and a second layer comprising a nickel-based alloy; and
a shim plate connected with the nozzle body, the shim plate comprising a plurality of slots in fluid communication with the passageway.

US Pat. No. 10,478,346

METHODS OF HANDLING ADHESIVE LAMINATE PATCHES

3M Innovative Properties ...

1. A method of handling adhesive laminate patches, the method comprising:providing a first article comprising a plurality of disconnected adhesive laminate patches adhered to a first web, wherein each patch is aligned over and adhered to a tab in the first web, such that a leading edge of each tab is located adjacent a leading edge of each patch;
providing a first supporting structure and a second supporting structure positioned adjacent the first supporting structure, wherein the second supporting structure and the first supporting structure are separated by a gap;
leading a second web over the second supporting structure, wherein the second web has a release surface, and wherein the second web is oriented such that the release surface of the second web faces the first supporting structure;
passing the first article over the first supporting structure to cause a leading portion of a first tab and a leading portion of a first patch aligned over the first tab to lift off of the first web together in such a way that the leading portion of the first patch is supported by the first tab and extends across the gap between the first supporting structure and the second supporting structure;
adhering the leading portion of the first patch to the second web on the second supporting structure; and
advancing the second web on the second supporting structure to transfer the first patch from the first web to the second web to form a second article comprising a plurality of patches aligned over tabs on the second web, wherein the patches are spaced apart longitudinally on the second web.

US Pat. No. 10,478,345

REDUCED-PRESSURE, LINEAR-WOUND TREATMENT SYSTEMS

KCI, Licensing Inc., San...

1. A closing dressing bolster for placing over a linear wound on a patient, the closing dressing bolster comprising:a top wall;
a bottom wall coupled to the top wall in a spaced relationship and forming a compartment between the top wall and the bottom wall, the bottom wall having a center portion, a first lateral portion, and a second lateral portion;
a plurality of beads positioned within the compartment;
a first closing member formed on the first lateral portion; and
a second closing member formed on the second lateral portion;
wherein the first closing member has a surface formed with an oblique angle to a center plane between the first closing member and the second closing member;
wherein the second closing member has a surface formed with an oblique angle to the center plane.

US Pat. No. 10,478,344

ADHESIVE EARPLUGS USEFUL FOR SEALING THE EAR CANAL

Tusker Medical, Inc., Me...

1. An earplug comprising:a dome-shaped portion for insertion into an ear canal, said dome-shaped portion having an outside surface and an inside surface;
a pressure sensitive adhesive positioned on the outside surface of the dome-shaped portion and configured to contact a surface of the ear canal to define a space in the ear canal between the dome-shaped portion and a tympanic membrane such that a solution delivered into the space can be retained in the space for a period of time; and
a liner in a folded configuration configured to protect the pressure sensitive adhesive when the dome-shaped portion with the pressure sensitive adhesive positioned thereon is inserted into the ear canal, the liner configured to unfold after the dome-shaped portion is positioned in the ear canal such that the pressure sensitive adhesive is exposed for contact with the surface of the ear canal.

US Pat. No. 10,478,342

OPHTHALMOLOGIC LASER DEVICE AND METHOD FOR PREVENTING AND TREATING AFTERCATARACT

CARL ZEISS MEDITEC AG, J...

1. An ophthalmologic laser device comprising:a pulsed laser configured to produce treatment laser pulses of a predetermined pulse energy that propagate along a treatment beam path;
a focusing lens system disposed in the treatment beam path;
a variably adjustable beam deflector unit disposed in the treatment beam path and configured to deflect the treatment laser pulses to different volumes;
a measuring equipment configured to determine a shape and position of optical interfaces along a detection beam path; and
a controller configured to control the pulsed laser and the variably adjustable beam deflector unit, the controller being configured to:
determine, using the measuring equipment, a shape and position of at least one interface of a membrane of a capsular bag of an eye located in a treatment area,
determine, based on the predetermined pulse energy, an effect distance over which a hypothetical pressure wave, which would be induced by irradiation of tissue in an interior space of the capsular bag of the eye with a laser pulse of the predetermined pulse energy, must propagate before an intensity of the hypothetical pressure wave has decreased to a level insufficient to tear the membrane of the capsular bag of the eye but sufficient to cause a photodisruption-free, non-linear interaction with the membrane that detaches cells or molecules from the membrane or deactivates the cells or molecules,
determine, as a function of the effect distance, coordinates of a center of a target volume, the center of the target volume being located at the effect distance from the at least one interface of the membrane of the capsular bag of the eye, and
adjust the deflector unit so as to deflect the treatment laser pulses produced by the pulsed lasr to the target volume.

US Pat. No. 10,478,341

SYSTEM AND METHOD FOR PLASMA-MEDIATED MODIFICATION OF TISSUE

OPTIMEDICA CORPORATION, ...

1. A method for cataract surgery on an eye of a patient, comprising:scanning a first focus position of a first pulsed laser beam at a first pulse energy in a first scanning pattern to photodisrupt a tissue structure of a lens of the eye with a plurality of pulses of the first laser beam to form a cut within the lens, the cut defining a two-dimensional cut surface formed by the scanned first focus positions of the first pulsed laser beam, the two-dimensional cut surface extending in a depth direction of the lens and being short of reaching an edge of the lens and further being short of reaching a posterior surface of the lens, and being configured to divide the lens into two or more segments which are attached to each other in regions adjacent the edge of the lens; and
thereafter, completely separating the two or more segments of the lens from each other by scanning a second focus position of a second pulsed laser beam having a second pulse energy higher than the first pulse energy in a second scanning pattern, wherein the scanned second focus positions of the second pulsed laser beam are disposed on the two-dimensional cut surface which have been formed by the scanned first focus positions of the first laser beam, wherein at least some of the scanned second focus positions are located deeper than some of the scanned first focus positions and shallower than some other scanned first focus positions, wherein a plurality of pulses of the second laser beam further photodisrupt the tissue structure of the lens along the two-dimensional cut surface formed by the scanned first focus positions of the first laser beam to drive the segments apart from each other,
wherein the completely separating step comprises:
scanning the second focus position of the second pulsed laser beam in a portion of the second scanning pattern;
using an imaging system or an optical coherence tomography (OCT) system, monitoring bubble creation and tissue displacement resulting from the scanning of the second focus position of the second pulsed laser beam in the portion of the second scanning pattern;
based on the monitored bubble creation and tissue displacement, determining whether a predefined level of tissue separation of the lens has occurred; and
if the predefined level of tissue separation of the lens has not occurred, scanning the second focus position of the second pulsed laser beam in another portion of the second scanning pattern.

US Pat. No. 10,478,339

SYSTEM AND METHOD FOR MANAGING PATIENT DATA DURING OPHTHALMIC SURGERY

Novartis AG, (CH)

1. An ophthalmic surgical device comprising:a surgical microscope;
a user interface;
an RFID read-write module operable read an RFID chip and write patient data to an RFID chip associated with a patient;
surgical instrumentation;
a warning system; and
a processor operable to:
receive data from the RFID chip associated with a patient, the data from the RFID chip comprising a first measurement of an eye;
receive data from the surgical microscope associated with the patient, the data from the surgical microscope comprising a second measurement of the eye;
compare the data from the RFID chip to the data from the surgical microscope;
determine whether the eye has changed by determining whether the data from the RFID chip varies from the data from the surgical microscope by more than a predetermined percentage;
generate a warning, if the data from the RFID chip and the data from the surgical microscope vary by more than the predetermined percentage; and
transmit the warning to the warning system, causing the warning system to present a warning.

US Pat. No. 10,478,337

MULTIPLE FREQUENCY PHACOEMULSIFICATION NEEDLE DRIVER

1. A system for operating a phacoemulsification handpiece at multiple operating frequencies, comprising:a first sine wave signal source configured to deliver a first sinusoidal signal at a first frequency;
a second sine wave signal source configured to deliver a second sinusoidal signal at a second frequency differing from the first frequency; and
a multi-tap transformer configured to receive the first sinusoidal signal at a first input tap and the second sinusoidal signal at a second input tap;
wherein an output tap of the multi-tap transformer connects to the phacoemulsification handpiece and drives the phacoemulsification handpiece at the first frequency, the second frequency, or a combination of the first frequency and the second frequency.

US Pat. No. 10,478,335

INTRAOCULAR DELIVERY DEVICES AND METHODS THEREFOR

OcuJect, LLC, Newport Be...

1. A method of loading a drug into a drug reservoir, comprising:providing a drug vial comprising a stopper and the drug within a vial cavity;
providing a drug reservoir injector comprising a distal port and the drug reservoir;
loading the drug reservoir with the drug from the vial through a needle assembly; removing the needle assembly from the drug reservoir system; and
connecting the drug reservoir injector with an injector attachment comprising:
a needle hub comprising a tubular body and comprising an input port on its proximal end for removable connection to the injector, and a distal stop surface;
a needle comprising a proximal portion and a distal portion, the proximal portion of the needle housed within the tubular body of the needle hub, and the distal end of the needle extending distally beyond the needle hub;
a rigid slidable shield comprising a distal opening, a proximal opening, and an uninterrupted sidewall between the distal opening and the proximal opening configured to protect the sterility of the needle and operatively coupled to the needle hub and having a fixed axial dimension, the slidable shield configured for axial movement along the needle hub between the input port and the distal stop surface and configured such that the needle is completely circumscribed by the shield and the distal portion of the needle hub when the shield is in a first, distal position with respect to the needle hub, and the distal portion of the needle extends distally beyond the shield when the shield is in a second, proximal position with respect to the needle hub,
a patient contact surface, the patient contact surface comprising a perimeter and located at a distal end of the slidable shield; and
a lever attached to the needle hub, the lever configured to prevent axial movement of the slidable shield and to maintain the shield in the first, distal position with respect to the needle hub by a locking shoulder at a distal end of the lever contacting a proximal end wall of the slidable shield thereby preventing proximal movement of the shield away from the first, distal position.

US Pat. No. 10,478,334

DEVICES AND METHODS FOR CUTTING LENTICULAR TISSUE

Carl Zeiss Meditec Catara...

1. A method of cutting a lens within a capsular bag of an eye, the lens having a posterior surface and an anterior surface, the method comprising:positioning a first portion of a cutting element of a device over the anterior surface of the lens with the cutting element in a first configuration, a second portion of the cutting element positioned within a lumen in a shaft of the device;
extending the second portion of the cutting element out of the lumen so that the cutting element expands toward a second configuration, the second configuration comprising an approximately closed loop formed entirely by the cutting element, said approximately closed loop having a first open area, wherein the first open area comprises a first, larger inner radius of curvature, a second, smaller inner radius of curvature, and wherein the approximately closed loop formed entirely by the cutting element extends both distally of a distal-most portion of the shaft and proximally of the distal-most portion of the shaft;
advancing the cutting element between the lens and the capsular bag so as to capture a portion of the lens within the first open area of the cutting element; and
tensioning the cutting element to cut the lens.

US Pat. No. 10,478,333

OCULAR IONTOPHORESIS DEVICE

OPIA TECHNOLOGIES, (FR)

1. An ocular iontophoresis device for delivering at least one active substance to an eyeball, comprising:a reservoir configured for receiving the at least one active substance,
a wall defining a tubular-shaped body arranged along a longitudinal axis, delimitating laterally the reservoir and comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding a cornea and a part of a sclera of the eyeball,
a first electrode configured to be positioned in front of the part of the sclera which is surrounded by the wall when the wall is in place on said ocular surface, said first electrode being configured for delivering a first current density to the at least one active substance of the reservoir, the ocular iontophoresis device being characterized in that it further comprises:
a second electrode configured to be positioned in front of the cornea when the wall is in place on said ocular surface, said second electrode being configured for delivering a second current density to the at least one active substance of the reservoir,
at least one controller for independently controlling said first electrode and said second electrode, and in that:
the second electrode defines a disk-shaped second surface that is arranged over a central part of the reservoir, the first electrode defining an annular-shaped first surface that is arranged over a peripheral part of the reservoir,
said first electrode and said second electrode arranged concentrically to each other, so that the first electrode and the second electrode are respectively positioned in front of part of the sclera and in front of the cornea, when the ocular iontophoresis device is positioned on said ocular surface,
wherein the reservoir comprises a separating wall defining a first chamber and a second chamber arranged concentrically to each other, the first chamber receiving the first electrode and the second chamber receiving the second electrode.

US Pat. No. 10,478,332

MAGNETIC OPERATING MICROSCOPES AND METHODS OF TREATMENT AND DIAGNOSIS USING THE SAME

EMMETROPE OPHTHALMICS LLC...

1. A device selected from an operating microscope with an attached magnet or an attachable magnet that is configured for attachment to the operating microscope, wherein the attached magnet, or the attachable magnet when attached to the operating microscope, is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of an intraocular magnetic field of sufficient magnitude and direction to move a magnetic therapeutic agent, a magnetic diagnostic agent, or both, that is positioned inside the tissue to a target location within the tissue.

US Pat. No. 10,478,330

OSTOMY APPLIANCE

Salts Healthcare Limited,...

1. An ostomy appliance having:first and fourth walls connected to each other at or near their peripheries, the first wall having a stoma-receiving opening;
second and third walls positioned in between the first and fourth walls;
a waste collecting cavity defined between either the first and second walls or between the first, second and fourth walls;
a second cavity defined between the second and third walls;
a third cavity defined between the third and fourth walls;
a first gas flow path in the second wall, wherein the first gas flow path permits waste gases to pass through the second wall from the waste collecting cavity to the second cavity;
a second gas flow path in the third wall, wherein the second gas flow path permits waste gases to pass through the third wall from the second cavity to the third cavity; and
a third gas flow path in the fourth wall, wherein the third gas flow path permits waste gases to escape through the fourth wall from the third cavity,
wherein the second and third walls are connected to each other at their peripheries and connected to each other by at least one additional connection located at a lower portion of the second and third walls to define a liquid flow path which permits liquid within the second cavity to flow into the waste collecting cavity.

US Pat. No. 10,478,324

HANDLE FOR MEDICAL DEVICE DEPLOYMENT

1. A delivery system for endoluminal delivery of an expandable device, said delivery system comprisinga catheter having a proximal end and an opposite distal end, the distal end configured to support the expandable device;
a primary sheath having a delivery position in which the primary sheath constrains the expandable device toward a collapsed configuration suitable for endoluminal delivery;
a handle having a first actuator that is rotatable and non-translatable wherein rotation of the first actuator causes axial displacement of the primary sheath along the catheter from the delivery position, the handle having a second actuator for operating one or more functions of the handle, wherein the second actuator is initially hidden to prevent use by a user and then revealed as a result of the axial displacement of the primary sheath along the catheter from the delivery position so as to allow subsequent actuation of the second actuator by the user.

US Pat. No. 10,478,322

RETRACTOR DEVICE FOR TRANSFORMING A RETRIEVAL DEVICE FROM A DEPLOYED POSITION TO A DELIVERY POSITION

Covidien LP, Mansfield, ...

1. A kit for retrieving material from a body of a subject, the kit comprising:a retrieval device including an elongated shaft and a retrieval assembly coupled to a distal zone of the elongated shaft, wherein—
the retrieval assembly includes a capture structure and a cover,
the cover has a first portion coupled to the distal zone of the elongated shaft and a free second portion, and
the cover has a first position in which the second portion extends proximally from the first portion, a second position in which the second portion extends distally from the first portion, and the cover surrounds at least a portion of the capture structure in the second position; and
a retractor having a tubular structure that defines a channel configured to slidably receive the retrieval device, wherein the tubular structure has a length no greater than twice a length of the capture structure measured along a longitudinal axis, and wherein the retractor is configured to extend distally beyond the capture structure to facilitate moving the cover from the second position after deployment to the first position for redeployment.

US Pat. No. 10,478,320

MODULAR ENDO-AORTIC DEVICE FOR ENDOVASCULAR AORTIC REPAIR OF DISSECTIONS AND BEING CONFIGURED FOR ADAPTABILITY OF ORGANS OF VARIOUS ANATOMICAL CHARACTERISTICS AND METHOD OF USING THE SAME

Aortic Innovations, LLC, ...

1. A kit comprising:a stent device for placement in the aorta arch of a patient, wherein a diameter of the stent device may be modified by translation of an end of the stent device to thereby alter a length thereof causing modification of the diameter of the stent device,
wherein the stent device comprises:
a distal stent portion that is permeable,
wherein the distal stent portion is a wireframe assembly that defines a circumferential periphery that spans but does not extend into the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient; and
a proximal portion that is impermeable and having a constraining member for constraining a diameter thereof,
wherein the proximal portion engages the distal stent portion at respective ends thereof such that the proximal portion is spaced-apart from the distant stent portion; and
a deployment apparatus comprising a sheath for housing the stent device and having a guide rod passing through a center therethrough for deploying the stent device at an operational site,
wherein the sheath constrains the distal portion of the stent device in a compressed state,
wherein the constraining member constrains the proximal portion of the stent device in a compressed state after removal of the sheath until release of the constraining member, and
wherein the guide rod carries the stent device and is removable through a center of the stent device when the stent device is in an expanded state and positioned within the aortic arch of the patient upon removal of the sheath.

US Pat. No. 10,478,317

METHODS AND TOOLS FOR HIP REPLACEMENT WITH SUPERCAPSULAR PERCUTANEOUSLY ASSISTED TOTAL HIP APPROACH

1. A surgical procedure for replacing a hip joint in an operative leg of a patient, comprisingmaking a main incision on an operative leg, the main incision is initiated at a point being a projection of a tip of a greater trochanter and extends proximally about a distance in the range of from 1 cm to 8 cm generally parallel to a femoral axis of the operative leg;
making an inline capsulotomy to expose a hip joint capsule for accessing a hip joint, the inline capsulotomy is performed while keeping muscles and posterior capsule intact;
preparing a femoral canal of a femur in the operative leg for receipt of a femoral implant;
resecting and removing a femoral head of the femur wherein the step of resecting and removing the femoral head comprises:
inserting a first Schanz pin into a solid part of the femoral head; and
moving the first Schanz pin to rotate the femoral head;
inserting a second Schanz pin into a different solid part of the femoral head; and
moving the second Schanz pin to rotate the femoral head; and
performing a step of acetabular preparation using a retractor comprising two tip rails, each tip rail having a plurality of tines, wherein the step of performing a step of acetabular preparation using the retractor having the two tip rails with the tines comprises:
placing a bone hook into a broach inside and along the femur, wherein the bone hook and the two tip rails are configured to form a three-point capsular distraction.

US Pat. No. 10,478,315

APPARATUS AND METHOD FOR INJECTING BONE GRAFT SUBSTITUTE AND OTHER MATERIALS

The University of Toledo,...

1. A metering delivery apparatus comprising:a body portion having a drive housing that supports an actuator drivetrain and receiver end;
a material containment vessel configured to dispense a quantity of material and supported on the receiver end such that a portion of the vessel is secured to the body portion and another portion of the vessel is moveable relative to the body portion;
an actuator having a first end connected to the actuator drivetrain and a second end configured to connect to and support the moveable portion of the vessel in both of a dispensing movement that exerts pressure on the material and a retracting movement that relieves pressure applied to the material; and
a control unit that receives actuator parameter inputs and includes a sensor to detect a signal of at least one of a pressure level and a time period, the sensor providing the detected signal to the control unit such that the control unit operates the actuator between the dispensing and retracting movements based on the detected signal and the actuator parameter inputs;
wherein the control unit includes a central processing unit (CPU) configured to receive the actuator parameter inputs and determine whether the detected signal is above or below a signal threshold value to operate the actuator and a display unit to display actuator operation parameters;
wherein the control unit includes a current sensor circuit configured to monitor a power consumption level of the actuator; and,
wherein the current sensor circuit detects at least one of an electrical current level flowing through the actuator and a voltage drop across the actuator during the dispensing and retracting movements, the circuit including an amplifier and a resistor, the CPU having an algorithm that determines the actuator power consumption from a voltage drop measurement from the actuator and a current level passing through the resistor.

US Pat. No. 10,478,314

SYSTEMS AND METHODS FOR PROVIDING A FEMORAL COMPONENT

1. A knee prosthesis comprising:a femoral component for replacing at least a portion of a distal end of a femur, the femoral component comprising:
posterior medial condylar component;
a medial femoral articular surface on the posterior medial condylar component; and
a proximal extension that extends at a proximal portion of the posterior medial condylar component,
wherein an articular surface of the proximal extension provides an indented articulation surface that is configured to articulate against a portion of at least one of a tibia and a tibial component.

US Pat. No. 10,478,313

SPINAL FUSION IMPLANT AND RELATED METHODS

NuVasive, Inc., San Dieg...

1. A spinal fusion implant for insertion between first and second vertebral bodies, each vertebral body having a cancellous bone interior bounded by a cortical bone exterior wall, each vertebral body having a curved anterior portion and a posterior portion curved to a lesser extent than the anterior portion, said posterior portion adjacent to a spinal canal, said spinal fusion implant comprising:a first vertebral body engagement side and a second vertebral body engagement side opposing said first vertebral body engagement side, an anterior side and a posterior side opposing said anterior side, a first end portion and a second end portion, a longitudinal axis extending through said first end portion and said second end portion, a central aperture situated between the first end portion and the second end portion and extending through the first vertebral body engagement side and the second vertebral body engagement side, a transverse plane extending from the anterior side to the posterior side at a right angle to the longitudinal axis and passing through a proximal-most point of the central aperture, said second end portion further including an engagement recess that extends distally toward the central aperture from a proximal end of the implant to a position short of the transverse plane and separates the second end portion into a top portion and a bottom portion, the top portion having at least one top aperture extending therethrough and configured to temporarily receive a complementary engagement feature on an insertion tool, and the bottom portion having at least one bottom aperture extending therethrough and configured to temporarily receive a complementary engagement feature on an insertion tool, wherein said top portion includes a top exterior surface forming part of the first vertebral body engagement side and a top interior surface, said bottom portion includes a bottom exterior surface forming part of the second vertebral body engagement side and a bottom interior surface, the at least one top aperture opening through said top exterior surf ace and said top interior surface, and the at least one bottom aperture opening through said bottom exterior surface and said bottom interior surface, wherein said at least one top aperture comprises a top center aperture and a plurality of smaller top radial apertures arranged around the top center aperture and said at least one bottom aperture comprises a bottom center aperture and a plurality of smaller bottom radial apertures arranged around the bottom center aperture.

US Pat. No. 10,478,311

MEDICAL DEVICES INCLUDING TITANIUM SURFACE TREATMENT

Globus Medical, Inc., Au...

1. A surgical implant comprising:a body sized and configured to be inserted in a disc space, the body comprising an upper surface and a lower surface, wherein at least one of the upper surface and lower surface comprises a surface treatment which contains primary cavities and secondary cavities, the primary cavities being larger than the secondary cavities, wherein the primary cavities have an average length ranging from 20-500 micrometers, and wherein the surface treatment comprises recasted material adjacent to a plurality of the primary cavities.

US Pat. No. 10,478,307

KNEE PROSTHESIS INCLUDING ROTATABLE POST

WM INNOVATIONS, LLC, Sta...

1. A knee joint prosthesis for a human tibia and femur, the knee joint prosthesis comprising:a tibial component comprising:
a tibial baseplate comprising a proximal surface including a sagittal axis, and an opposing distal surface; and
a tibial stem extending from the distal surface of the tibial baseplate and including a cavity therein;
a tibial bearing disposable on the proximal surface of the tibial baseplate, the tibial bearing comprising:
a first bearing portion positionable on a first side of the sagittal axis and having a first shape;
a second bearing portion positionable on a second side of the sagittal axis and having a second shape different than the first shape; and
an aperture alignable with the cavity of the tibial stem;
a post extendable through the aperture of the tibial bearing and disposable in the cavity of the tibial component, the post rotatable relative to the tibial baseplate and the tibial bearing, the post together with the first bearing portion and the second bearing portion configured to promote the femur to substantially pivot about the first bearing portion; and
a collar extending radially from the post and engageable with the tibial baseplate around the cavity and engageable with the bearing aperture to limit movement of the femur along a coronal plane of the femur.

US Pat. No. 10,478,305

STEERABLE LESION EXCLUDING HEART IMPLANTS FOR CONGESTIVE HEART FAILURE

BioVentrix, Inc., San Ra...

1. A method for treating a heart, the heart having a first chamber bordered by a septum and a wall, wherein the chamber comprises a left ventricle of the heart, the heart having a second chamber separated from the first chamber by the septum, the method comprising:providing a perforation device having a distal tip that is configured to deliver electrosurgical energy to heart tissue to enable the perforation device to penetrate through the heart tissue;
penetrating, via the perforation device, the septum at a first location selected for deployment of an implant;
penetrating, via the perforation device, the wall at a second location selected for the deployment of the implant;
controllably steering the perforation device between the first location and the second location; and
deploying the implant by affixing a first anchor of the implant adjacent the penetration of the septum, affixing a second anchor of the implant adjacent the penetration of the wall, and applying tension between the first anchor and the second anchor;
wherein the tensioned members are tensioned sufficiently to bring the wall and septum into engagement, and thereby effectively exclude a region of the wall and septum from the left ventricle with scar tissue extending along the excluded region.

US Pat. No. 10,478,302

MATERIAL FOR TREATMENT OF A HEART VALVE, IN PARTICULAR A MITRAL VALVE

MEDTRONIC CV LUXEMBOURG S...

1. An apparatus for treating a heart valve, comprising:a catheter configured for percutaneous introduction through a minimally invasive vascular access;
a guide member deployable from a distal end of the catheter, the guide member having a distal portion of a length that is configured to extend from the distal end of the catheter such that when the guide member is deployed for treating the heart valve the distal portion of the guide member extends from a proximal side to a distal side of a valve annulus and a bent shape of the distal portion of the guide member is configured to engage the distal side of the valve annulus; and
an implant having a helical shape and being disposed within the catheter being spiraled around the guide member, and being rotatable relative to the guide member, the implant being detachably connected to an actuator that is disposed within the catheter, the actuator being configured to rotate the implant about the guide member and to distally advance the implant relative to the guide member,
wherein the implant is configured to be deployed from the distal end of the catheter and to penetrate the tissue of the valve annulus while longitudinally advancing along and rotating relative to the deployed distal portion of the guide member.

US Pat. No. 10,478,301

CONVERTIBLE ANNULOPLASTY RING CONFIGURED TO RECEIVE AN EXPANDABLE PROSTHETIC HEART VALVE

Edwards Lifesciences Corp...

1. An annuloplasty ring, comprising:an annuloplasty support frame consisting of a single contiguous segment defining a circumferential shape surrounding a ring opening as seen when view from above, wherein the annuloplasty support frame is configured to transition from a first configuration to a second configuration only upon being subjected to a radially expansive force in vivo of at least 2 atm, and wherein in the first configuration the ring opening is “D”-shaped and in the second configuration the ring opening is more circular than the “D-shaped” first configuration, and wherein the annuloplasty support frame remains in the first configuration prior to being subjected to the radially expansive force and a transition from the first configuration to the second configuration occurs suddenly.

US Pat. No. 10,478,300

BOND BETWEEN COMPONENTS OF A MEDICAL DEVICE

BOSTON SCIENTIFIC SCIMED,...

1. An elongated member comprising:a first elongated rod;
a second elongated rod;
a third elongated rod mandrel;
wherein the first, second, and third elongated rods each include a proximal end and a flattened distal portion;
wherein the first, second, and third elongated rods are fixed together such that the flattened distal portions of the first, second, and third elongated rods are arranged perpendicular to radii extending out from a shared central axis of the first, second, and third elongated rods at 120-degree radial intervals;
a coupling element having a lumen and a proximal end;
wherein the first, second, and third elongated rods are disposed within the lumen and are fixedly attached to the coupling element;
wherein the coupling element includes a proximal portion having a first outer diameter and distal portion having a second outer diameter greater than the first outer diameter; and
an elongate shaft having a distal lumen
wherein the proximal portion of the coupling element is inserted into the distal lumen of the elongate shaft such that the distal portion of the coupling element abuts the distal end of the elongate shaft and is fixedly attached thereto.

US Pat. No. 10,478,299

LOW CROSSING PROFILE DELIVERY CATHETER FOR CARDIOVASCULAR PROSTHETIC IMPLANT

DFM, LLC, Incline Villag...

1. A method of deploying a cardiovascular prosthetic implant, the method comprising the steps of:translumenally advancing a catheter having a distal portion with a diameter of 18 French and carrying a cardiovascular prosthetic implant with a tissue valve having a thickness of at least about 0.011 inches to a position proximate a native valve of a patient, wherein the cardiovascular prosthetic implant comprises an inflatable cuff, a tissue valve coupled to the inflatable cuff;
inflating the inflatable cuff fully with a hardenable inflation media; and
removing the catheter from the patient, leaving the hardenable inflation media in the cardiovascular prosthetic implant within the patient.

US Pat. No. 10,478,289

REPLACEMENT VALVE AND ANCHOR

BOSTON SCIENTIFIC SCIMED,...

1. An implantable prosthetic heart valve, comprising:a stent having a distal inflow region defining a distal end of the stent and a distalmost inflow outer diameter, a central region having a central outer diameter, and a proximal outflow region defining a proximal end of the stent and a proximalmost outflow outer diameter; and
a plurality of leaflets coupled to the stent;
wherein the proximalmost outflow outer diameter is greater than the central outer diameter;
wherein the proximalmost outflow outer diameter is greater than the distalmost inflow outer diameter; and
wherein the distalmost inflow outer diameter is greater than the central outer diameter.

US Pat. No. 10,478,288

TRILEAFLET MECHANICAL PROSTHETIC HEART VALVE

Clover Life Sciences Inc....

1. A trileaflet mechanical prosthetic heart valve comprising:a ring including three or more protrusions located along an inner circumference of the ring;
three or more hinges attached to the ring, the three or more hinges evenly spaced from one another along the inner circumference of the ring; and
three or more leaflets, each leaflet attached to one of the three or more hinges, each leaflet attached to a hinge by an opening located in a center of a lower portion of the leaflet, each leaflet including:
a front surface having a concave shape in a transverse axis and a flat shape in a longitudinal axis,
a rear surface having a convex shape in the transverse axis and a flat shape in the longitudinal axis, the rear surface of the leaflets configured to be in contact with the protrusions of the ring when the leaflets are in an open position such that there is an arc shaped gap formed between the rear surface of the leaflets and the inner circumference of the ring when the leaflets are in the open position, wherein the the rear surface of the leaflets substantially tracks the inner circumference of the ring when the leaflets are in the open position; and
flat regions on left and right sides of the front surface of the leaflets, the flat regions for improved fluid dynamics.

US Pat. No. 10,478,286

ARTIFICIAL VESTIBULAR ORGAN SYSTEM

INHA UNIVERSITY RESEARCH ...

1. An artificial vestibular organ system comprising: an artificial semicircular canal;an artificial hair in the artificial semicircular canal configured to generate an electrical or magnetic signal according to changes in position; and
a body stimulation pulse generation unit configured to generate a body stimulation pulse using the electrical or magnetic signal generated from the artificial hair to transmit the body stimulation pulse to an ampulla,
wherein the artificial hair is disposed on one surface of an interior of the artificial semicircular canal and is configured to sense a movement of a liquid.

US Pat. No. 10,478,284

METHODS FOR TISSUE PASSIVATION

The General Hospital Corp...

1. A method of preventing or decreasing intimal hyperplasia within a human blood vessel, the method comprising exposing an intact, non-proliferative, exterior surface of the human blood vessel to a cross-linking tissue structure stabilizing agent (“TSSA”) that does not penetrate beyond an external layer of collagen in the exterior surface under conditions sufficient to promote cross-linking of proteins within the exterior vascular surface while preserving normal tissue architecture of regions of the human blood vessel beyond the external layer of collagen, thereby preventing or decreasing intimal hyperplasia within the human blood vessel.

US Pat. No. 10,478,280

METHODS AND DEVICES FOR DELIVERING AND SECURING ADJUNCT MATERIALS TO A TREATMENT SITE

Ethicon LLC, Guaynabo, P...

1. A method for stapling tissue, comprising:activating an applicator to deliver a flowable adjunct precursor to a tissue within a body cavity with the applicator; and
after the flowable adjunct precursor solidifies to form an adjunct, engaging the tissue and the adjunct with opposed jaws on an end effector of a surgical stapling device, and actuating the surgical stapling device to deliver at least one staple through the adjunct and the tissue.

US Pat. No. 10,478,278

SURGICAL ARTICLES AND METHODS

Boston Scientific Scimed,...

1. A system for treating urinary incontinence, the system comprising:a multi-piece implant including a support portion piece and an extension portion piece, the support portion piece including a tissue support portion sized and shaped for placement to support a urethra, the extension portion piece including a proximal end, a distal end, and a tissue fastener, the extension portion piece being adjustably connected to the support portion piece at an adjusting engagement; and
an adjusting tool including a proximal end portion, a shaft, and a distal end portion, the distal end portion of the adjusting tool including a surface configured to engage the support portion piece, the shaft including a moveable holder configured to move along at least a portion of a length of the shaft, the movable holder configured to engage the proximal end of the extension portion piece and move the proximal end in a proximal or distal direction along the shaft.

US Pat. No. 10,478,277

BIOABSORBABLE MESH FOR SURGICAL IMPLANTS

Boston Scientific Scimed,...

1. An implantable mesh comprising:a plurality of absorbable fibers;
a plurality of non-absorbable fibers, the plurality of absorbable fibers being aligned in a first direction and the plurality of non-absorbable fibers i-s being aligned in a second direction, the second direction being substantially perpendicular to the first direction, to form openings between the plurality of absorbable fibers and the plurality of non-absorbable fibers,
the plurality of absorbable fibers being interwoven or knitted with the plurality of non-absorbable fibers to form a mesh structure,
the plurality of absorbable fibers being configured to degrade after implantation into a human subject; and
an absorbable polymer, the absorbable polymer being located at least some of the openings.

US Pat. No. 10,478,272

METHODS AND APPARATUSES FOR FORMING A THREE-DIMENSIONAL VOLUMETRIC MODEL OF A SUBJECT'S TEETH

Align Technology, Inc., ...

1. An intraoral scanning system, comprising:a hand-held wand configured to operate with one or more sensors to detect infrared and visible light, wherein the one or more sensors comprises an image sensor;
a sleeve configured to be placed over a distal end of the hand-held wand having a window at a distal end region; and
one or more processors operably connected to the hand-held wand, the one or more processors configured to:
receive visible light information and infrared information from the one or more sensors;
determine, in real time, surface information from the visible light information and generate a three-dimensional (3D) surface model of a subject's teeth using the surface information;
display the 3D surface model on a display screen in real time as the hand-held wand is moved;
capture, in real time using the image sensor, one or more two-dimensional (2D) images of an internal region of the subject's teeth from the infrared information; and
display, on the display screen, the one or more 2D images of the internal region of the subject's teeth.

US Pat. No. 10,478,271

ORTHODONTIC APPLIANCE FOR DISTALIZATION AND/OR SPACE CLOSURE

1. An orthodontic system for distalization and space closure, comprising:an anterior orthodontic appliance comprising two bonding pads contoured for attaching to a lingual side of a patient's teeth; two spaced apart elongated vertical connectors attaching a netted structure to the two bonding pads in a mesial-distal direction apical to the two bonding pads, the netted structure and the two spaced apart elongated vertical connectors being rigidly formed; wherein the netted structure comprises a body having a first engaging structure and a second engaging structure, each of said first and second engaging structures is comprised of at least one of a hole, a hook, a stop, and a combination thereof;
a posterior orthodontic appliance spaced from the anterior orthodontic appliance, said posterior orthodontic appliance having two ends and a central portion with at least one opening; and
at least one force delivering component configured to be selectively attached to the first engaging structure or the second engaging structure of the netted structure, securing the central portion of the posterior orthodontic appliance to the netted structure of the anterior orthodontic appliance such as to deliver a desired level and direction of force vectors to a dentition; wherein first force vectors are present when the at least one force delivering component is secured to the first engaging structure in the netted structure, and second force vectors are present when the at least one force delivering component is secured to the second engaging structure in the netted structure, wherein the first force vectors and the second force vectors have different values of level and direction.

US Pat. No. 10,478,270

DENTAL ARCH AND AIRWAY EXPANDER DEVICE AND METHOD

1. An orthodontic appliance for treatment of a patient, comprising:a. left and right attachment units, structured to be secured respectively to left and right molars, joined together by an expandable frame;
b. wherein said expandable frame includes first and second selectively expandable arms, each joined to one of said left and right attachment units and being joined together by a selectively expandable anterior bridge, said selectively expandable anterior bridge, when expanded, pushes said first and second selectively expandable arms further apart;
c. wherein each said first and second selectively expandable arms includes:
i. an arm shaft having a first end attached to one of said left and right attachment units and a second end having a head expanded in transverse dimension;
ii. an arm sheath, receiving said head expanded in transverse dimension, which is captured by a narrowed sheath exit;
iii. an arm position-adjustable block, positioned on said arm shaft, outside of said arm sheath, and including a position lock;
iv. an arm spring positioned around said arm shaft and having a first end joined to said arm sheath and a second end joined to said arm position-adjustable block;
d. wherein said selectively expandable anterior bridge includes:
i. a first bridge shaft attached to said arm sheath of said first selectively expandable arm, said first bridge shaft having a bend and supporting a bridge sheath;
ii. a second bridge shaft attached to said arm sheath of said second selectively expandable arm, and bending inwardly toward said bridge sheath, and having an expanded in transverse dimension head, retained in said bridge sheath by a narrowed exit;
iii. a bridge position-adjustable block, positioned on said second bridge shaft, outside of said bridge sheath, and including a position lock;
iv. a bridge spring positioned around said second bridge shaft and having a first end joined to said bridge sheath and a second end joined to said bridge position-adjustable block;
e. whereby a user-selectable force, chosen from a set of two alternative force applications that consists of:
i. a force application of pushing rearward; and
ii. a force application of pulling forward may be applied to either molar by changing the position of either arm position-adjustable block, to place either arm spring into a state selected from a set of two alternative states that consist of:
i. a state of compression and;
ii. a state of tension; and
f. whereby a user-selectable force, chosen from a set of two alternative force applications that consists of:
i. a force application of pushing outward; and
ii. a force application of pulling inward may be applied to both molars by changing the position of said bridge position-adjustable block, to place said bridge spring into a state selected from a set of two alternative states that consist of:
i. a state of compression; and
ii. a state of tension.

US Pat. No. 10,478,268

ELECTRIC MOTOR AND DENTAL DEVICE

NAKANISHI INC., Tochigi ...

1. A brushless electric motor comprising:a stator that includes a stator core and a plurality of coils, the plurality of coils being disposed at an inner circumference side of the stator core;
a rotor that includes a shaft, the rotor being rotated around the shaft with respect to the stator;
a medium pathway through which a medium passes, the medium being used for actualizing a function of an application object of the electric motor; and
a holder member that holds the plurality of coils,
wherein the plurality of coils are adjacent to each other in a rotation direction of the rotor so as not to lap mutually,
wherein the medium pathway is disposed between the adjacent coils,
wherein the holder member includes:
a cylinder portion, the plurality of coils being disposed on an outer circumference of the cylinder portion, and
a flange that is formed integrally as a single unit with the cylinder portion to project from the cylinder portion in a radially outward direction, and
a plurality of convex portions that are arranged to protrude from the outer circumference of the cylinder portion, wherein each of the plurality of coils is configured to be fitted to one of the plurality of convex portions, and
wherein the medium pathway penetrates the flange.

US Pat. No. 10,478,267

ORAL IRRIGATOR

TOOTHSHOWER LLC, College...

1. An oral irrigator comprising:a) a water delivery system for connecting a source of high pressure water to an inlet of a
pick;
b) a mouth rinse delivery system for connecting a reservoir of mouth rinse to said inlet of said pick;
c) a handle comprising:
i) a blocking valve comprising:
1) a blocking valve inlet;
2) a blocking valve outlet;
3) a body comprising an internal channel connecting said blocking valve inlet to said blocking valve outlet; and
4) a spring loaded valve button wherein:
a) said spring loaded valve button is biased to a normally open position; and
b) said spring loaded valve button will close off said internal channel when urged closed; and
ii) a hand pump comprising:
1) a spring loaded piston at least in part defining a fluid chamber within the hand pump and movable to vary a volume of the fluid chamber, wherein said spring loaded piston is biased to a normally expanded configuration;
2) a pump button attached to said spring loaded piston such that said spring loaded piston will be compressed when pressure is placed on said pump button;
3) an inlet check valve fluidly connected to said fluid chamber and configured to allow fluid flow into said fluid chamber; and
4) an outlet check valve fluidly connected to said fluid chamber and configured to allow fluid flow out of said fluid chamber;whereinsaid hand pump is mounted adjacent to said blocking valve such that said valve button will be urged closed when pressure is put on said pump button thus shutting off said source of high pressure water to said pick and allowing said mouth rinse to be pumped into said pick from said reservoir using said hand pump.

US Pat. No. 10,478,266

ILLUMINATED SURGICAL PROBE HAVING MULTIPLE OPTICAL FIBERS

Novartis AG, Basel (CH)

1. An illuminated surgical probe system, comprising:a surgical probe having a probe needle;
a first optical fiber incorporated onto the probe needle, wherein a distal end of the first optical fiber projects a first beam of illumination light over a tip of the probe needle when activated;
a second optical fiber incorporated onto the probe needle, wherein a distal end of the second optical fiber projects a second beam of illumination light over the tip of the probe needle when activated;
a third optical fiber incorporated onto the probe needle, wherein a distal end of the third optical fiber projects a third beam of light over the tip of the probe needle to perform a distance measurement between the probe needle and a patient's retina when activated, wherein the distance measurement is displayed or audibly presented to aid a user in positional awareness of the probe needle with respect to the patient's retina; and
a processor that, based on the distance measurement, automatically toggles the illumination light between the first beam having a first numerical aperture that facilitates vitreous visualization and the second beam having a second numerical aperture that facilitates background illumination, wherein the second numerical aperture is larger than the first numerical aperture.

US Pat. No. 10,478,265

CRANIAL FIXATION DEVICE

Integra LifeSciences Corp...

1. A cranial fixation device comprising:a cap comprising:
a central body having a mating connector with a threaded portion projecting from a distal end of the central body;
a pair of wings extending radially out from the central body; and
a first opening extending from a proximal end of the central body to the distal end of the central body and through the threaded portion of the mating connector, a base comprising:
a threaded central opening corresponding to the threaded portion of the mating connector, the threaded central opening being positioned on a proximal end of the base;
a distal threaded portion configured to engage with an opening in a skull;
a pair of wings extending radially out from the threaded central opening; and
a second opening extending through the threaded central opening and the distal threaded portion; and
a compression grommet configured to be placed into the threaded central opening of the base, the compression grommet having a third opening extending from a proximal end of the compression grommet to a distal end of the compression grommet, the first opening, the second opening and the third opening being aligned when the cap mates with the base and forms an instrument lumen configured to accept a portion of an instrument cable,
the threaded portion of the cap being configured to mate with the threaded central opening of the base, and
at least one wing of the pair of wings of the cap having a projection protruding in a direction towards the base, and each wing of the pair of wings of the base having a seat,
wherein, when the instrument cable extends through the instrument lumen, the projection from at least one wing of the pair of wings of the cap and at least one of the seats in the pair of wings of the base are configured to create a torque stop when a predetermined compression of the compression grommet is applied by tightening the cap on the base, and
when the predetermined compression of the compression grommet is applied, the compression grommet compresses against the instrument cable fixing the instrument cable in place at a determined depth.

US Pat. No. 10,478,264

APPARATUS AND METHOD FOR APPLYING LIGHT IN OCULAR AND PERIOCULAR AREAS

LUMENIS LTD., Yokneam (I...

1. A method of protecting ocular tissue during application of light energy, the method comprising:providing a handpiece having a light energy device, the handpiece having a tip having a shielding extension configured to be inserted posterior to an eyelid;
inserting the shielding extension behind the eyelid prior to applying light energy to the eyelid;
applying light energy from the light energy device to the eyelid;
wherein the light energy device comprises an LED; and
wherein the shielding extension is comprised of a sufficiently thermally insulative material such that heat from a target tissue is prevented from reaching ocular tissue located posterior to the eyelid in a quantity that would damage the ocular tissue.

US Pat. No. 10,478,261

SYSTEM, METHOD, AND APPARATUS FOR REMOTE PATIENT CARE

DEKA Products Limited Par...

1. A portable patient-care kit, comprising:two-housing portions pivotally coupled together to form a container space;
a plurality of compartments disposed within at least one of the two-housing portions, each compartment configured to retain at least one medical apparatus;
a central control unit comprising a touch-screen user interface device having a transceiver configured to communicate via a mobile data network; and
a light bar disposed along an exterior of one of the two-housing portions configured to provide light;
a plurality of lights, each of the plurality of lights being configured to supply light within a separate one of each of the plurality of compartments,
wherein a compartment of the plurality of compartments includes a door, wherein the touch-screen user interface device is in operative communication with the door to instruct the door to automatically open, and
wherein the central control unit is configured to illuminate the plurality of lights so as to illuminate the plurality of compartments and the at least one medical apparatus retained therein in a sequence of operation, the control unit configured to automatically illuminate a next compartment in the sequence of operation based on data from at least one of the at least one medical apparatus.

US Pat. No. 10,478,258

METHODS, SYSTEMS, AND DEVICES FOR CONTROLLING A MOTOR OF A ROBOTIC SURGICAL SYSTEM

Ethicon LLC, Guaynabo, P...

1. A surgical apparatus, comprising:a motor of a robotic surgical system, the motor being configured to provide torque to a surgical tool removably and replaceably coupled to the robotic surgical system, and the motor including a first plurality of magnets configured to generate a first electromagnetic field and a second plurality of magnets configured to generate a second electromagnetic field, wherein the motor is configured to provide a first amount torque to the surgical tool and a second amount of torque to the surgical tool in response to interference of the second electromagnetic field with the first electromagnetic field.

US Pat. No. 10,478,257

ROBOTIC SURGICAL TOOL, SYSTEM, AND METHOD

Ethicon LLC, Guaynabo, P...

1. A robotic surgical tool, comprising:a housing configured to couple to a surgical robot;
an elongate shaft extending distally from the housing and having an end effector coupled to a distal end thereof, at least a portion of the elongate shaft being rotatable; and
a belt coupled to the elongate shaft, the belt being configured to indicate a rotational position of the elongate shaft with respect to an initial rotational position of the elongate shaft, the belt including a stop protrusion surrounding an outer perimeter of the belt and configured to prevent rotation of the elongate shaft beyond a preselected maximum rotation position.

US Pat. No. 10,478,256

ROBOTICS TOOL BAILOUTS

Ethicon LLC, Guaynabo, P...

1. A surgical tool, comprising:a housing having a plurality of motor-driven drive gears;
an elongate shaft extending distally from the housing;
an end effector coupled to a distal end of the elongate shaft;
at least first and second actuation assemblies, each actuation assembly being coupled to one of the plurality of motor-driven drive gears such that each of the motor-driven drive gears is configured to drive a corresponding actuation assembly, the first actuation assembly being configured to operate a first function of the end effector, and the second actuation assembly being configured to operate a second function of the end effector that is different than the first function; and
at least first and second bailout mechanisms, the first bailout mechanism being selectively engageable with the first actuation assembly and being configured to be manually driven to subsequently drive the first actuation assembly, and the second bailout mechanism being selectively engageable with the second actuation assembly and being configured to be manually driven to subsequently drive the second actuation assembly, the first bailout mechanism including a first one-way gear, the second bailout mechanism including a second one-way gear, each of the first and second one-way gears being configured to be rotatable in only one direction to drive the corresponding first and second actuation assembly.

US Pat. No. 10,478,255

SYSTEM AND METHOD FOR HOLOGRAPHIC IMAGE-GUIDED PERCUTANEOUS ENDOVASCULAR PERCUTANEOUS PROCEDURES

THE CLEVELAND CLINIC FOUN...

1. A method comprising:receiving, by a head-mounted device comprising a processor, tracking data for a physical interventional device in a tracking coordinate system, wherein the physical interventional device is used during an endovascular percutaneous medical procedure;
transforming, by the head-mounted device, the tracking data for the physical interventional device in the tracking coordinate system into a headset coordinate system;
accessing, by the head-mounted device, image data from a pre-operative image of a patient's anatomy comprising a physical operative site in an imaging coordinate system;
transforming, by the head mounted device, the image data in the imaging coordinate system into the headset coordinate system;
registering, by the head-mounted device, a 3D holographic representation of the interventional device based on the tracking data for the physical interventional device in the headset coordinate system to 3D anatomical holographic projections of the patient's anatomy based on the imaging data in the headset coordinate system;
displaying, by the head mounted device, the 3D anatomical holographic projections providing a visualization of a holographic version of the patient's anatomy with reference graphics related to a physical operative site within the patient's anatomy;
displaying, by the head mounted device, the 3D holographic representation of the interventional device providing a visualization of a holographic version of the interventional device with guidance control graphics related to the physical interventional device; and
navigating, by the head mounted device, the 3D holographic representation of the interventional device in the 3D anatomical holographic projections based on the tracking data for the interventional device in the headset coordinate system,
wherein the reference graphics and the guidance control graphics provide guidance for tracking the physical interventional device through the patient's anatomy using the 3D anatomical holographic projections and the 3D holographic representation of the interventional device.

US Pat. No. 10,478,254

SYSTEM AND METHOD TO ACCESS LUNG TISSUE

COVIDIEN LP, Mansfield, ...

1. A method for providing tool navigation assistance comprising:tracking a location of a first sensor disposed on a distal portion of a catheter using an electromagnetic tracking system;
tracking a location of a second sensor disposed on a tool positionable through a lumen of the catheter using the electromagnetic tracking system when the second sensor is in a first position within a patient coordinate frame of reference and when the second sensor is in a second position within the patient coordinate frame of reference;
determining a distance between a target site within a patient's body and the tracked location of the first sensor;
displaying the determined distance between the target site and the tracked location of the first sensor;
determining a distance between the tracked location of the first sensor and the tracked location of the second sensor in the first position;
determining a distance between the tracked location of the second sensor in the first position within the patient coordinate frame of reference and the tracked location of the second sensor in the second position within the patient coordinate frame of reference;
determining a distance between the tracked location of the first sensor and the tracked location of the second sensor in the second position by adding the determined distance between the tracked location of the first sensor and the tracked location of the second sensor in the first position and the determined distance between the tracked location of the second sensor in the first position and the tracked location of the second sensor in the second position;
displaying the determined distance between the tracked location of the first sensor and the tracked location of the second sensor in the second position; and
determining whether the second sensor is advanced to the target site.

US Pat. No. 10,478,253

SYSTEM AND METHOD FOR PROVIDING SURGICAL GUIDANCE BASED ON POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

SYNAPTIVE MEDICAL (BARBAD...

1. A system comprising:a laser emitting linearly polarized light; one or more fiber couplers; an Optical Coherence Tomography (OCT) reference arm including a first quarter wave plate (QWP); an OCT sample arm including a second QWP; one or more polarization beam splitters (PBS); a first detector and a second detector for each of the one or more PBSs,
the linearly polarized light being split between the OCT reference arm and the OCT sample arm by the one or more fiber couplers, the OCT reference arm configured to: reflect reference polarized light back to the one or more fiber couplers after the reference polarized light passes twice through the first QWP; and the OCT sample arm configured to scan polarized light across a sample after the linearly polarized light passes through the second QWP; and convey sample light from the sample back through the second QWP to the one or more fiber couplers,
the one or more fiber couplers further interfering the reference polarized light with the sample light into combined light, and conveying the combined light to the one or more PBSs, the one or more PBSs splitting the combined light into first polarization state light and second polarization state light, the first polarization state light detected by the first detector, and the second polarization state light detected by the second detector,
wherein light is conveyed between optical components using polarization-maintaining (PM) optical fibers,
wherein respective PM optical fibers conveying the light between the one or more fiber couplers and each of the OCT reference arm and the OCT sample arm comprises: respective fiber pigtails optically connected to the one or more fiber couplers using a connector-free optical connection, and
wherein one or more of the respective fiber pigtails is respectively connected to the OCT reference arm and the OCT sample arm using a respective connector-free optical connection.

US Pat. No. 10,478,252

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

HeartFlow, Inc., Redwood...

1. A computer-implemented method for enabling the assessment of one or more blood vessels of a patient, based on calculated values of a blood flow characteristic, the method comprising:receiving patient-specific imaging data of a geometry of a plurality of blood vessels interconnected to form a vessel tree of the patient;
determining, using a processor, a three-dimensional geometrical model of the plurality of blood vessels interconnected to form the vessel tree of the patient, based on the received patient-specific imaging data, the three-dimensional geometrical model comprising a model, in three dimensions, of a geometry of the plurality of blood vessels;
determining, using the processor, a patient-specific model of blood flow through the plurality of blood vessels interconnected to form the vessel tree of the patient, based on the received patient-specific imaging data, the patient-specific model of blood flow comprising a model of the flow of blood through the plurality of blood vessels;
determining a first value of the blood flow characteristic within the plurality of blood vessels of the patient based on the three-dimensional geometrical model or the patient-specific model of blood flow through the plurality of blood vessels of the patient;
upon receiving a selection, from a user input received from a user or health care provider, of a blood vessel of the plurality of blood vessels interconnected to form the vessel tree, enabling a modification of one or both of the patient-specific model of blood flow and a geometry of the three-dimensional geometrical model to simulate an occlusion that prevents blood flow through the blood vessel of the plurality of blood vessels interconnected to form the vessel tree;
modifying the patient-specific model of blood flow to prevent blood flow through the blood vessel of the plurality of blood vessels to simulate occlusion of the blood vessel of the plurality of blood vessels interconnected to form the vessel tree;
predicting a change in blood flow, based on the occlusion, in vessels of the vessel tree different from the blood vessel having the occlusion, based on the modified patient-specific model of blood flow and/or the modified three-dimensional geometrical model;
determining a second value of the blood flow characteristic within the plurality of blood vessels of the patient based on the modified three-dimensional geometrical model reflecting the occlusion, and/or the modified patient-specific model of blood flow reflecting the occlusion;
predicting an effect on the patient of the occlusion based on the second value of the blood flow characteristic; and
outputting one or more of the first or second values of the blood flow characteristic, the modified three-dimensional geometrical model, the modified patient-specific model of blood flow, or the predicted effects, to an electronic storage medium or display.

US Pat. No. 10,478,251

STEERABLE AND CONTROLLABLE MEDICAL LASER FIBERS

SRGI HOLDINGS LLC, Hende...

1. A device comprising:a catheter section comprising a distal end and a proximal end;
a flexible joint region located at the distal end and including a lumen formed by tubing that runs through the catheter section, wherein a distal end of the flexible joint region includes a portion of the tubing extending as an extension past a distal end of the flexible region;
a laser fiber disposed within the catheter section, wherein the laser fiber emits laser light at a fiber distal end;
a wire comprising a distal end coupled to the catheter section, wherein the wire is a push-pull wire configured to be pushed distally and pulled proximally along a longitudinal axis of the wire such that translation of the wire distally or proximally effects flexion of the distal end of the catheter section about the flexible joint region, wherein a distal portion of the wire has a smaller diameter than a proximal portion of the wire.

US Pat. No. 10,478,250

ELECTROSURGICAL RETURN ELECTRODE AND RFID SYSTEM

Megadyne Medical Products...

1. An electrosurgical return electrode comprising:a conductive element configured to conduct electrical current, the conductive element having opposing first and second major surfaces and including an aperture array configured to allow passage of a magnetic, electric, or electromagnetic interrogation signal from an associated transponder detection unit through the conductive element, and
a patient contact pad positioned adjacent the first major surface of the conductive element and configured to be disposed between the conductive element and a patient when the patient is at least partially positioned upon the patient contact pad;
wherein the electrosurgical return electrode is configured to be at least partly positionable upon the transponder detection unit with the second major surface facing the transponder detection unit, and
wherein the aperture array is configured to be adjustable between an open configuration and a closed configuration to thereby adjust the magnetic, electric, or electromagnetic transparency of the electrosurgical return electrode.

US Pat. No. 10,478,248

ELECTROPORATION ABLATION APPARATUS, SYSTEM, AND METHOD

Ethicon LLC, Guaynabo, P...

1. An ablation apparatus attachable to an elongate shaft, the ablation apparatus comprising:a first probe configured to extend through a first lumen defined in the elongate shaft, the first probe comprising:
a distal end configured to protrude beyond a distal end of the elongate shaft; and
a proximal end, wherein a first bore is longitudinally defined by the first probe between the distal end and the proximal end of the first probe, and wherein the proximal end of the first probe is coupleable to a source of suction to extract tissue through the first bore;
a first electrode attached to the distal end of the first probe external to the elongate shaft;
a first conductor electrically coupled to the first electrode;
a second probe configured to extend through a second lumen defined in the elongate shaft, the second probe comprising:
a distal end configured to protrude beyond the distal end of the elongate shaft; and
a proximal end, wherein a second bore is longitudinally defined by the second probe between the distal end and the proximal end of the second probe, and wherein the proximal end of the second probe is coupleable to the source of suction to extract tissue through the second bore;
a second electrode attached to the distal end of the second probe external to the elongate shaft; and
a second conductor electrically coupled to the second electrode;
wherein the first probe and the second probe are rotatable and translatable relative to the first lumen and the second lumen respectively, and wherein the first electrode and the second electrode are rotatably and translatably positionable with respect to one another, via the first probe and the second probe, to define a region between the first electrode and the second electrode.

US Pat. No. 10,478,246

ABLATION OF TISSUE WITHIN VERTEBRAL BODY INVOLVING INTERNAL COOLING

Relievant Medsystems, Inc...

1. A method of accessing and ablating tissue within a vertebral body involving internal cooling, the method comprising:inserting a stylet within a cannula;
percutaneously inserting the stylet and the cannula through skin of a patient;
advancing the stylet and the cannula within the vertebral body using a transpedicular approach through a first pedicle using real time image guidance;
removing the stylet from the cannula;
inserting a channeling tool through the cannula to create a working channel beyond a path formed by the stylet within the vertebral body using real time image guidance;
removing the channeling tool from the cannula;
identifying a treatment zone within the vertebral body to include an anterior-posterior distance;
inserting a first radiofrequency probe through the cannula to the treatment zone within the vertebral body using real time image guidance,
wherein the first radiofrequency probe comprises a bipolar probe having a first two electrodes, wherein a return electrode of the first two electrodes is spaced proximally from an active electrode of the first two electrodes,
inserting a second radiofrequency probe within the vertebral body through a second pedicle and to the treatment zone using real time image guidance,
wherein the second radiofrequency probe comprises a bipolar probe having a second two electrodes, wherein a return electrode of the second two electrodes is spaced proximally from an active electrode of the second two electrodes;
wherein the first and second radiofrequency probes are coupled to a single generator,
causing energy within a frequency range between 400 kHz and 600 kHz to be delivered to the treatment zone within the vertebral body using the first and second radiofrequency probes for a duration of time sufficient to ablate tissue at the treatment zone,
wherein the tissue comprises at least one of a basivertebral nerve and a tumor,
wherein the first radiofrequency probe comprises one or more diagnostic devices configured to provide diagnostic information in connection with treatment of the tissue; and
causing cooling fluid to circulate through one or more lumens of at least one of the first and second radiofrequency probes to provide cooling to the treatment zone.

US Pat. No. 10,478,245

ENERGIZABLE ATTACHMENT FOR SURGICAL DEVICES

Covidien LP, Mansfield, ...

1. A surgical system, comprising:a surgical instrument, including:
a housing;
a shaft extending distally from the housing; and
an end effector assembly disposed at a distal end of the shaft, the end effector assembly defining a distal end; and
a selectively engagable energizable surgical attachment, including:
an outer sheath defining a proximal end and a distal end and including an internal surface defining a lumen extending longitudinally through the outer sheath, the outer sheath configured for positioning about the shaft of the surgical instrument;
an energizable rod member coupled to the outer sheath, wherein the outer sheath and the energizable rod member are configured to translate about the shaft of the surgical instrument between a retracted position, wherein the entire outer sheath and the entire energizable rod member are proximally-spaced from the distal end of the end effector assembly, and a deployed position, wherein the outer sheath and the energizable rod member extend distally from the distal end of the end effector assembly, the energizable rod member and the outer sheath rotatable relative to the surgical instrument in both the retracted position and the deployed position;
a connector attachment disposed towards the proximal end of the outer sheath, the connector attachment electrically coupled to the energizable rod member; and
at least one o-ring disposed within the lumen of the outer sheath and coupled to the internal surface of the outer sheath, the at least one o-ring configured to establish a fluid-tight seal between the outer sheath and the shaft of the surgical instrument and to bias the outer sheath towards a stationary position relative to the shaft of the surgical instrument,
the proximal end of the outer sheath of the energizable surgical attachment spaced apart from a distal-most end of the housing of the surgical instrument in both the retracted and deployed positions.

US Pat. No. 10,478,242

BONE CEMENT MIXING CARTRIDGE AND METHOD OF USE

Encore Medical, L.P., Au...

1. A container for bone cement, the container comprising:a first member defining a first chamber operable to contain a first ingredient;
a port connected to the first chamber, the port configured for dispensing bone cement from the first chamber, and the port further configured for coupling the first chamber to a vacuum source;
a second member comprising
a second chamber operable to contain a second ingredient, the second member defining the second chamber;
a sealing member sealing the second chamber,
an extension member extending through a central aperture to the first chamber, the extension member including a passage defined therein, the passage at least partially defining the second chamber,
a mixing device coupled to the extension member and disposed within the first chamber, the mixing device movably disposed within the first chamber; and
an opening device positioned within the first chamber and operable for selectively opening the sealing member allowing the second ingredient to enter the first chamber, the mixing device being movable within the first chamber to promote mixing of the first ingredient and the second ingredient to prepare the bone cement.

US Pat. No. 10,478,241

ARTICULATING OSTEOTOME WITH CEMENT DELIVERY CHANNEL

Merit Medical Systems, In...

1. A medical device for treating hard tissue, comprising: a conduit having a series of slots along a first side of an articulating distal portion of the conduit; a rod extending through the conduit, the rod including a flexible portion; a handle including an actuating portion coupled to a proximal end of the rod, wherein movement of the actuating portion results in an associated movement of the rod and the conduit to selectively move the articulating distal portion between a linear configuration and an articulated configuration; and a side port coupled to the handle with an insertion guide that extends to an accessible portion of the conduit extending along the conduit to a distal end of the conduit; further comprising a lumen inserted in the insertion guide and extending through the conduit, wherein the lumen is semicylindrical, and wherein the semicylindrical flexible portion of the rod and the lumen are positioned within the conduit to form a cylinder that fills the conduit.

US Pat. No. 10,478,240

DEVICE FOR PERFORMING A SURGICAL PROCEDURE AND METHODS OF USE

1. A method comprising:providing a device comprising an expandable first tubing portion, an expandable second tubing portion, a transition portion, and a substantially rigid outer member, the first tubing portion and the second tubing portion being joined by the transition portion, the first tubing portion extending through a first passage extending through the substantially rigid outer member, and the second tubing portion extending outwardly from the substantially rigid outer member;
creating an access path to a bone;
inserting the device into the access path to position at least a first inflatable lobe portion and a second inflatable lobe portion of the second tubing portion within the bone;
passing an inflation medium through a second passage formed by an inner surface of the first tubing portion, through a third passage formed by an inner surface of the transition portion, and into a chamber formed by an inner surface of the second tubing portion, the inner surfaces of the first tubing portion, the transition portion, and the second tubing portion being continuous with one another;
preventing the first tubing portion from expanding via contact of an outer surface of the first tubing portion with an inner surface of the substantially rigid outer member;
inflating the first inflatable lobe portion and the second inflatable lobe portion of the second tubing portion from uninflated positions to inflated positions with the inflation medium by expanding the first inflatable lobe portion and the second inflatable lobe portion; and
compressing a portion of the bone and create a cavity via inflation of the first inflatable lobe portion and the second inflatable lobe portion.

US Pat. No. 10,478,239

PEDICLE SCREW ASSEMBLY

Spinal Balance, Inc., Ho...

1. A pedicle screw assembly comprising:a head assembly including a tulip having a U-shaped pocket defined by a pair of extending arms, each of the extending arms including a threaded inner surface and a threaded outer surface;
a threaded shank portion extending from the tulip;
a retaining nut threadably engaged with the threaded outer surface of the extending arms; and
a set screw threadably engaged with the threaded inner surface of the extending arms, wherein the set screw outwardly deflects the extending arms against the retaining nut such that the retaining nut is frictionally prevented from rotating.

US Pat. No. 10,478,238

ACTIVE COMPRESSION DEVICES, METHODS OF ASSEMBLY AND METHODS OF USE

ActivOrtho, Inc., Plymou...

1. A bone fixation device comprising:a first member comprising a proximal end of the device;
a second member comprising a distal end of the device;
at least one deformable member positioned between the first member and the second member configured to lengthen the device upon compression;
wherein the first member comprises an opening extending from a second end towards a first end along at least a portion of the first member that defines an interior surface in the first member;
wherein the interior surface comprises at least one channel extending along at least a portion of a length of the first member;
wherein the second member comprises an exterior surface having a shaft region near a first end of the second member, wherein the shaft region comprises:
at least one depression near the first end of the second member; and
at least one channel extending from the first end of the second member towards a second end of the second member;
the bone fixation device further comprising a ring member shaped to engage the first member and the second member;
wherein the interior surface of the first member further comprises:
a groove proximate the second end of the first member; and
wherein the at least one channel extends from the groove;
wherein the ring member comprises
a body portion having an exterior surface removably coupled to the groove; and
at least one protrusion extending away from an interior surface of the body portion of the ring member, the at least one protrusion shaped to engage the at least one channel of the shaft region of the second member.

US Pat. No. 10,478,237

ORTHOPEDIC BONE PLATE SYSTEM

OsteoCertus, LLC, Pembro...

1. A bone plate for repair of a bone, consisting of:a planar metal plate consisting of a first side, an opposite second side, and a plurality of nodes and intervening bridges extending in a linear arrangement,
the plurality of nodes having a longitudinal channel at each of the first and second sides of the plate, rails extending longitudinally along the longitudinal channels at each of the first and second sides of the plate, a countersunk screw hole countersunk between and relative to the rails at each of the first and second sides of the plate, and bilaterally extending wings that laterally taper in thickness, and
the bridges having a reduced area moment of inertia relative to the nodes such that the bridges have an increased propensity to bending relative to the nodes when a force is applied thereto,
wherein the first and second sides of the plate have a same structure such that each of the first and second sides are configured to be positioned against and in contact with the bone.

US Pat. No. 10,478,236

METAL ALLOY MONO AND POLY-FILAMENT WIRE REINFORCED CARBON FIBER PLATING SYSTEM

Elemental Orthopedics LLC...

1. A device for use in skeletal fixation, comprising: an orthopedic plate comprising at least one metal alloy mono-filament and/or poly-filament wire infrastructure between at least two sheets consisting of carbon fiber, resin, and hardener, wherein said wire infrastructure is positioned to provide reinforcement and increase internal rigidity of said plate while retaining radiolucent regions of said plate.

US Pat. No. 10,478,235

SURGICAL TOOL

Warsaw Orthopedic, Inc., ...

1. A surgical tool comprising:a housing;
a motor positioned within the housing;
a sleeve portion coupled to the housing;
a spline drive positioned within the sleeve portion;
a motor shaft coupled to the motor, a proximal end of the motor shaft extending through an opening in the spline drive;
a hex drive output gear, a distal end of the motor shaft extending through an opening in the hex drive output gear; and
an output shaft, the sleeve portion being moveable relative to the housing between a first position in which the output shaft is spaced apart from the motor shaft and a second position in which the output shaft engages the motor shaft,
wherein splines of the spline drive engage a channel within the sleeve portion such that the splines move radially outward and are coupled with a lip portion of the hex drive output gear as the sleeve portion moves from the first position to the second position.

US Pat. No. 10,478,234

INTERSPINOUS IMPLANT AND IMPLANTATION INSTRUMENT

LDR Medical, Rosieres Pr...

1. An interspinous implant configured to be implanted between two adjacent dorsal spines, each including an upper edge, a lower edge and two opposed lateral faces, wherein the implant includes at least one body with dimensions arranged so as to maintain or restore a distance between the adjacent edges of the two spinous processes and including at least two wings extending so that at least a part of each wing lies along at least a part of one lateral face of one of the two spinous processes and, additionally, at least one retainer for the implant, designed to retain the body of the implant between the two spinous processes and to be inserted from the same lateral face as the body;wherein the retainer includes an insert and the implant comprises at least one passage passing through at least one part of the body and including a shape, dimensions and orientation arranged for insertion, through the body, of at least one insert including at least one curved plate retained within the body so that at least a part of the said curved plate lies along at least a part of one lateral face opposite the at least one lateral face along which one wing lies; and
wherein the body includes two wings each arranged on one lateral face of the implant opposite the other wing and each extending toward one of the two spinous processes, so that the wings each lie along one spinous process, but on opposite lateral faces, the insert being of substantially sigmoidal shape due to its plate including at least two radii of curvature of opposite orientations, so that both faces of the plate include both a concave and a convex part, the passage and the insert being arranged in such a way that, when the insert is lodged in the passage, at least one portion of the said convex parts of the two faces of the insert each lies along at least one part of the spinous processes, on the lateral faces opposite those which the wings lie along.

US Pat. No. 10,478,232

INTERSPINOUS PROCESS DEVICE AND METHOD

NuVasive Specialized Orth...

1. An interspinous process device configured for placement between adjacent spinous processes on a subject's spine comprising:a housing comprising: a lead screw fixedly secured at one end thereof, a first mounting surface, and an upward facing hook pivotally coupled to the first mounting surface configured to configured to cradle a lower portion of a first spinous process, the upward facing hook configured to be pivoted between a low-profile configuration during insertion and a deployed configuration, and the upward facing hook having a stop configured to abut the first mounting surface to hold the upward facing hook static in the deployed configuration;
a magnetic assembly at least partially disposed within the housing, the magnetic assembly comprising:
a hollow magnet having a longitudinally extending bore defining an inner surface, the hollow magnet configured for rotation within the magnetic assembly, the hollow magnet comprising an internally threaded insert affixed to the inner surface of the bore, the internally threaded insert configured to coaxially engage with the lead screw; and
a downward facing hook pivotally coupled to a second mounting surface of the magnetic assembly, the downward facing hook configured to cradle an upper portion of a second spinous process, the downward facing hook configured to be pivoted between a low-profile configuration during insertion and a deployed configuration, and the downward facing hook having a stop configured to abut the second mounting surface to hold the downward facing hook static in the deployed configuration;
wherein an externally applied magnetic field rotates the hollow magnet, and wherein rotation of the hollow magnet in a first direction effectuates telescopic movement of the magnetic assembly out of the housing.

US Pat. No. 10,478,231

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:a body including opposite first and second surfaces and opposite top and bottom surfaces, the top and bottom surfaces extending from the first surface to the second surface, the body including an inner surface that defines a passageway that extends through the top and bottom surfaces, the body further including a bay that extends into the first surface; and
a locking element comprising a screw and a fixation element, the screw being positioned within the passageway and including a non-threaded proximal portion and a threaded shank extending from the proximal portion, the proximal portion having a maximum diameter that is greater than a maximum diameter of the shank, the shank defining a longitudinal axis, the fixation element being coupled directly to the proximal portion such that the fixation element is translatable relative to the body along the longitudinal axis.

US Pat. No. 10,478,225

TOOL COMPRESSED INSERT FOR CLOSURE INDEPENDENT LOCKING OF A PIVOTAL BONE ANCHOR ASSEMBLY

Roger P. Jackson, Prairi...

1. A pivotal bone anchor assembly for securing an elongate rod to a bone with a closure via closure independent locking with an insert compressing tool, the pivotal bone anchor assembly comprising:a receiver having a base defining a cavity communicating with a bottom opening, and a pair of upright arms extending upwardly from the base to define an open channel for receiving the elongate rod, the open channel communicating with the cavity to define a central bore, the pair of upright arms including:
opposed inward-facing surfaces having a discontinuous helically wound closure-mating structure formed therein; and
outward-facing surfaces having receiver tool engagement structures formed therein for releasable overlapping engagement with the insert compressing tool;
a bone anchor having a capture portion pivotally disposed within the receiver cavity and an anchor portion extending distally from the capture portion and through the receiver bottom opening for fixation to the bone; and
a compression insert at least partially disposed within the receiver center bore and having an upper surface configured for engagement with the elongate rod, the insert having a central opening and upward-facing surfaces on tool engagement structures positioned radially outward from the central opening,
wherein the the receiver tool engagement structures and the insert upward-facing tool engagement structures are configured for simultaneous non-threadable engagement and downward compressing engagement, respectively, by the insert compressing tool, thereby applying a downward force to independently lock a position of the bone anchor with respect to the receiver prior to securing the elongate rod within the receiver open channel via the closure, and
wherein the closure is positionable within the channel while the position of the bone anchor with respect to the receiver is so independently locked by the insert compressing tool.

US Pat. No. 10,478,223

ENDOSCOPIC TREATMENT TOOL

OLYMPUS CORPORATION, Tok...

1. An endoscopic treatment tool comprising:a sheath;
an operating wire inserted into the sheath and being configured to advance and retract;
a basket part positioned at a distal side of the operating wire and formed by binding a plurality of elastic basket wires having helical shapes in a natural state;
a distal end tip which binds and fixes distal ends of the plurality of basket wires at a distal end of the basket part;
a binding part in which proximal end portions of the plurality of basket wires are bound together and fixed; and
a support member disposed through the basket part along a central axis of the basket part, a proximal end portion of the support member being positioned inside the sheath, and a distal end portion of the support member being fixed to the distal end tip; and
a connecting member positioned more proximally than the binding part, the connecting member including an insertion hole, the support member being configured to be inserted into the insertion hole to connect the proximal end portion of the support member to the operating wire inside the sheath, the proximal end portion of the support member being provided along a longitudinal axis of the operating wire.

US Pat. No. 10,478,222

METHOD OF SECURING PERIANAL SUPPORT DEVICE

Stetrix, Inc., Oakland, ...

1. A method of inhibiting perianal tissue distention of a patient during a child birthing process, comprising:providing a support member having an engagement surface configured for engaging perianal tissue of the patient as the patient pushes during at least a portion of the child birthing process;
positioning the engagement surface in a first supporting position in engagement with the perianal tissue of the patient prior to delivery of a child;
securing the support member in the first supporting position relative to the perianal tissue; and
maintaining the first supporting position of the support member on at least a portion of perianal tissue during at least one push of the child birthing process.

US Pat. No. 10,478,221

INTRODUCER FOR INTRODUCTION OF A PROSTHESIS INTO A LUMEN OF A PATIENT

Cook Medical Technologies...

1. An introducer for introduction of a prosthesis into a lumen of a patient, the introducer comprising: a sheath having a proximal end and a distal end; a housing mounted to the distal end of the sheath, the housing having a passage there-through adapted to receive a delivery assembly; a port for introducing flushing fluid, the port communicating with the passage; a liquid absorbing seal for sealably receiving the delivery assembly, a material of the liquid absorbing seal composed of a hydrogel, the liquid absorbing seal disposed within the housing distally of the port; and a compression assembly operable to compress the liquid absorbing seal comprising a rotatable body and a compression segment, wherein the compression segment is disposed between the liquid absorbing seal and the rotatable body and is a separate component to the rotatable body, and wherein the compression segment and the rotatable body are mutually arranged and constructed to allow rotation of the rotatable body relative to the compression segment; whereby introduction of a flushing fluid through the port into the passage results in absorption of a portion of the flushing fluid into the hydrogel.

US Pat. No. 10,478,216

ATHERECTOMY DEVICES AND METHODS

Cardio Flow, Inc., St. P...

1. A method for performing rotational atherectomy to remove stenotic lesion material from a blood vessel of a patient, the method comprising:navigating a rotational atherectomy device within the blood vessel, the rotational atherectomy device comprising an elongate flexible drive shaft defining a longitudinal axis and including helically wound metallic filars that form a coil having an outer diameter;
advancing a distal tip portion of the drive shaft past stenotic lesion material within the blood vessel;
after advancing the distal tip portion past the stenotic lesion material, advancing a concentric metallic stability element affixed to the coil of the drive shaft past the stenotic lesion material, the concentric metallic stability element having a center of mass aligned with the longitudinal axis;
after advancing the concentric metallic stability element past the stenotic lesion material, advancing a distal-most eccentric abrasive element of an array of at least three eccentric abrasive elements past the stenotic lesion material while causing a rotary actuator coupled to the drive shaft to rotate the drive shaft about the longitudinal axis, the eccentric abrasive elements affixed to the drive shaft such that a center of mass of each eccentric abrasive element is offset from the longitudinal axis, each eccentric abrasive element being spaced apart from an adjacent eccentric abrasive element, wherein said causing the rotary actuator to rotate the drive shaft about the longitudinal axis causes the distal-most eccentric abrasive element to move in an orbital path to abrade the stenotic lesion material.

US Pat. No. 10,478,215

ATHERECTOMY DEVICES AND METHODS

Cardio Flow, Inc., St. P...

1. A system for performing rotational atherectomy to remove stenotic lesion material from a blood vessel of a patient the system comprising:an elongate tube defining a lumen; and
a rotational atherectomy device comprising:
an elongate flexible drive shaft comprising helically wound metallic filars that form a coil having an outer diameter, the drive shaft defining a longitudinal axis;
an array of at least three eccentric spherical abrasive elements being fixed to the drive shaft such that a center of mass of each abrasive element is offset from the longitudinal axis; and
a metallic stability element having a cylindrical shape defining an inner diameter, the metallic stability element being fixed to the helically wound metallic filars of the drive shaft the metallic stability element having a center of mass aligned with the longitudinal axis; and
a distal-most extension portion that extends distally of the metallic stability element to a distal free end;
wherein the drive shaft, the abrasive elements, and the metallic stability element rotate together about the longitudinal axis,
wherein the distal-most extension portion extends distally of the metallic stability element for a distal extension distance,
wherein the distal-most extension portion is distally spaced apart from a distal-most abrasive element of the eccentric spherical abrasive elements by a distal separation distance, and
wherein the center of mass for each eccentric spherical abrasive elements in said array is offset from the longitudinal axis while contemporaneously the center of mass of the metallic stability element is aligned with the longitudinal axis, and
wherein the distal separation distance being greater than an element spacing distance, wherein each abrasive element is spaced apart from an adjacent abrasive element by the element spacing distance.

US Pat. No. 10,478,214

BALLOON CATHETER WITH LITHOTRIPSY AMPLIFICATION SYSTEM

Cook Medical Technologies...

1. An intraluminal scoring system comprising:a balloon comprising an outer surface, a proximal portion, and a distal portion, wherein the proximal and distal portions are attached to a catheter, and wherein the outer surface inflates radially from the catheter;
a wire comprising proximal and distal portions, wherein the distal portion of the wire extends along the outer surface of the balloon;
a scoring element comprising a contacting surface directly secured to the outer surface of the balloon, wherein the distal portion of the wire is enclosed within the scoring element, and the distal portion of the wire comprises a projection extending radially through an opening on the scoring element; and
a lithotripter coupled to the proximal portion of the wire, wherein the lithotripter may be activated to transmit mechanical energy from the lithotripter, through the wire to vibrate the distal portion of the wire.

US Pat. No. 10,478,212

METHOD AND SYSTEM FOR HARVESTING BIOLOGICAL TISSUE

Medline Industries, Inc.,...

1. A method for manufacturing hollow needles, the method comprising the steps of:a. stamping a needle design into a sheet of material, wherein the needle design comprises a row of a plurality of hollow needles to be formed and a carrier, wherein the needle design of each of the plurality of hollow needles comprises a plurality of needle tips and at least one narrow heel;
b. processing the stamped needle design, including sharpening the plurality of needle tips and the at least one narrow heel; and
c. rolling the stamped, processed needle design to form the row of hollow needles wherein each hollow needle comprises a plurality of sharp tips, and at least one sharp narrow heel and wherein each needle remains attached to the carrier.

US Pat. No. 10,478,207

SURGICAL GRASPER

Vanderbilt University, N...

1. A surgical grasper comprising:a first handle arm;
a second handle arm coupled to the first handle arm; and
a lock that locks relative movement between the first and second handle arms, the lock including:
a first ratchet arm fixed to the first handle arm;
a second ratchet arm coupled to the second handle arm;
a pusher element slidably coupled to the second ratchet arm that moves the second ratchet arm toward and away from the first ratchet arm; and
a lockout element releasably coupled to the pusher element that locks a position of the pusher element.

US Pat. No. 10,478,204

STONE RETRIEVAL BALLOON CATHETER

CALCULA TECHNOLOGIES, INC...

1. A method for removing a urinary tract stone, the method comprising:advancing a distal end of a ureteroscope into a body lumen to a location near the urinary tract stone;
advancing a distal end of a flexible stone removal device out of the distal end of the ureteroscope;
sliding a basket slider distally along a handle of the stone removal device to advance a wire basket out of an inner shaft of the stone removal device, thus allowing the wire basket to expand;
sliding the basket slider proximally along the handle to trap the urinary tract stone within the wire basket;
inflating an inflatable balloon on the stone removal device;
sliding an inversion slider proximally along the handle to invert a rounded distal tip of the inflatable balloon, wherein the inversion slider is frictionally coupled with the basket slider, and wherein sliding the inversion slider proximally automatically slides the basket slider proximally to pull the wire basket and the trapped urinary tract stone into the rounded distal tip of the inflatable balloon; and removing the ureteroscope and the stone removal device from the body lumen, along with the urinary tract stone, while the urinary tract stone is at least partially located inside the inflatable balloon.

US Pat. No. 10,478,203

SNARE INSTRUMENT WITH SNARE STRUCTURE FORMED FROM A TUBE SECTION

1. A snare instrument comprisingan enclosure; and
a snare structure placed in the enclosure, where the snare structure is formed by a tube section that extends from a proximal end of a proximal base portion to a distal end of a distal snare portion, the tube section including:
a plurality of open slits formed in the distal end of the tube section, with each open slit extending a distance L in an axial direction toward the proximal base portion, and
a plurality of closed wire sections, with each closed wire section located between a first open slit of the plurality of open slits and a second open slit of the plurality of open slits adjacent to the first open slit, where each closed wire section is formed by a channel opening, and the channel opening is spaced a distance Bd away from the distal end of the tube section such that the closed wire section is closed at the distal end of the tube section by a curved wire section, where the curved wire section has a radius of curvature R;
wherein the channel opening is semi-circular and the radius of curvature R of the curved wire section is at least a factor of 2.5 greater than the distance Bd;
wherein the snare structure is movable between a snaring position characterized by the snare structure moved forward in a distal direction out of the enclosure and a securing position characterized by the snare structure moved back in a proximal direction into the enclosure;
wherein, when in the snaring position, the snare structure forms a cup shape having a distal snare opening that is approximately circular;
wherein n is defined as a number of the plurality of open slits, and a circumferential length of the distal snare circular opening is 70% or more of the product of 2 nL.

US Pat. No. 10,478,200

GLENOID RESURFACING SYSTEM AND METHOD

Arthrosurface Incorporate...

1. A method for repairing a defect on a portion of an articular surface of a patient's glenoid, said method comprising:advancing an excision device along a working axis and said working axis is positioned at an angle ? relative to the articular surface, wherein angle ? is less than or equal to 90 degrees, wherein said excision device includes a shaft and at least one cutter extending radially outwardly from said shaft, wherein said at least one cutter is generally aligned in a single plane extending along a longitudinal axis of said shaft; and
rotating said excision device about said working axis to form a generally hemi-spherical excision site within the articular surface of the glenoid.

US Pat. No. 10,478,196

COMPRESSION DEVICE AND PRESSURE SENSOR FOR TREATMENT OF ABNORMAL UPPER ESOPHAGEAL SPHINCTER FUNCTIONALITY

The Medical College of Wi...

1. A compression device for reducing pharyngeal reflux in a subject, the compression device comprising:a frame;
a clasp;
a strap having a first end section attached to the frame and an opposite second end section attached to the clasp, a length of the strap between the first end section and the second end section being adjustable; and
a cushion disposed on the frame, wherein the clasp is configured to engage at least a portion of the frame, such that the clasp fastens the strap to the frame to position the cushion over a cricoid of the subject and to apply a predetermined amount of pressure to the cricoid in order to reduce pharyngeal reflux in the subject while allowing the subject to open an upper esophageal sphincter of the subject for other physiological events;
an adjustment mechanism for moving the cushion toward or away from the frame, wherein the adjustment mechanism comprises a plate and a position adjustor movably attached to the plate, the position adjustor being located on a first side of the frame, the plate having a first surface and an opposite second surface, the first surface of the plate being attached to the cushion, the second surface of the plate being in contact with a second side of the frame; and
wherein the clasp is configured to unfasten the strap from the frame and to refasten the strap to the frame to reapply the predetermined amount of pressure to the cricoid.

US Pat. No. 10,478,195

DEVICES, SYSTEMS, AND METHODS FOR THE TREATMENT OF VASCULAR DEFECTS

Covidien LP, Mansfield, ...

1. A vascular occlusion device for treating an aneurysm, wherein a neck of the aneurysm opens to a blood vessel, the device comprising:a proximal portion having a mesh configured to be positioned within the aneurysm;
a distal portion including a directing region having:
a proximal terminus that coincides with a proximal terminus of the distal portion,
a distal terminus, wherein the directing region extends along a first direction that runs through the proximal terminus and the distal terminus, and
a length measured along the first longitudinal direction between the proximal terminus and the distal terminus; and
an intermediate mesh portion between the proximal and distal portions that, when in a deployed configuration, forms a preset bend in the device that orients the first longitudinal direction of the directing region at an angle to a portion of the proximal portion adjacent the intermediate mesh portion, wherein the angle is between about 45 degrees and about 135 degrees, and
wherein, when the device is being pushed distally out of a delivery catheter into the aneurysm, the directing region directs the distal portion to inhibit the distal portion from exiting the aneurysm through the neck such that the proximal portion crosses the neck and generally remains within the aneurysm,
wherein the device is configured to be implanted within the aneurysm.

US Pat. No. 10,478,193

CATHETER MAINTAINING BLOOD FLOW BY VEIN BYPASS

BEBILLER YAZILIM MEDIKAL ...

1. A catheter apparatus (1) maintaining blood flow by vein bypass, made of a plastic and similar raw materials, that is open on both ends, characterized in that the catheter apparatus comprises:a first path connecting both ends,
one balloon (3) on a point close to each of both ends,
a protective layer (4) positioned on each of the balloons (3),
a second path (5) enabling deflation and inflation of the balloons (3), having a monolithic pipe shape adhered side by side to the first path (2), whose one open end terminates within the balloon (3),
a check valve apparatus (7) that is monolithic with a back end of the second path (5) and provides substances such as air and liquid with an external injector for inflation and deflation of the balloon (3),
a protective segment (6) surrounding externally the first path (2) and second path (5), thus preventing blockage of the first path and second path when compressed, the protective segment configured to have various lengths from a back end of the balloon (3) to a backside of the catheter (1), and is monolithic along with the first path (2) and the second path (5),
a cover (8) that prevents the catheter apparatus (1) from going out of the vein or movement of the catheter apparatus, that is located on a body side of the catheter apparatus (1), positioned on the back of the balloon (3), that can be moved over the catheter apparatus (1) as it is wider than a width of the body of the catheter apparatus (1), that has a flexible structure having both ends open, configured to have a shape of a funnel or a circle or an ellipsis or different shapes,
a clamping apparatus (9) used to fix the cover on a relevant location,
at least a third path (10) in the shape of a pipe with both ends open, having one end positioned within the first path (2), another end located out of the first path (2) and used to draw the liquid or air,
a connection apparatus (11) that is integrated with an outer back end of the third path (10) and that enables connection with the external injector and catheters.

US Pat. No. 10,478,192

DETACHMENT MECHANISMS FOR IMPLANTABLE DEVICES

Boston Scientific Scimed,...

1. An assembly, comprising:an implantable device that includes a structure having a plurality of adjacent windings extending therefrom; and
a detachment mechanism that includes a first electroactive polymer and a second electroactive polymer each configured to reversibly engage the structure between two of the adjacent windings;
wherein the first and second electroactive polymers move from an expanded configuration to an unexpanded configuration such that the first and second electroactive polymers overlap each other, upon application of heat or electrical energy, to release the implantable device.

US Pat. No. 10,478,191

BUTTRESS ATTACHMENT FOR CIRCULAR STAPLING DEVICE

Covidien LP, Mansfield, ...

1. An anvil assembly, comprising:a circular anvil head having a first engaging feature and supporting a crush ring member;
an anvil cap having a second engaging feature that connects with the first engaging feature of the anvil head to secure the anvil cap to the anvil head, the anvil cap being movable relative to the anvil head between an approximated position and an unapproximated position, the crush ring member being spaced from the second engaging feature when the anvil cap is disposed in the approximated position and movable into engagement with the second engaging feature to move the anvil cap to the unapproximated position; and
a circular anvil buttress member including a body portion and an extension portion that extends from the body portion, the body portion supported on a tissue engaging surface of the anvil head, the extension portion being secureable between the anvil cap and the anvil head when the anvil cap is disposed in the approximated position, the extension portion being releasable from between the anvil cap and the anvil head when the anvil cap is disposed in the unapproximated position so that the body portion separates from the tissue engaging surface of the anvil head.

US Pat. No. 10,478,189

METHOD OF APPLYING AN ANNULAR ARRAY OF STAPLES TO TISSUE

Ethicon LLC, Guaynabo, P...

1. A method of operating a surgical instrument, wherein the surgical instrument comprises:(a) a body;
(b) a shaft assembly extending distally from the body;
(c) a stapling head assembly located at the distal end of the shaft assembly, wherein the stapling head assembly comprises a distal surface, wherein the stapling head assembly is operable to drive an annular array of staples through the distal surface;
(d) an anvil, wherein the anvil is configured to couple with the stapling head assembly;
(e) an anvil adjustment assembly, wherein the anvil adjustment assembly comprises a translating member, wherein the translating member is operable to translate relative to the body along a longitudinal axis defined by the body to thereby adjust the longitudinal position of the anvil relative to the distal surface of the stapling head assembly;
(f) a first trigger, wherein the first trigger is operable to actuate the stapling head assembly to thereby drive the annular array of staples through the distal surface toward the anvil; and
(g) a lockout assembly, wherein the lockout assembly comprises an electrically powered braking feature, wherein the electrically powered braking feature further comprises an actuator that defines an enclosure and a lock member that extends from inside the enclosure from a retracted position to an extended position, wherein the lockout assembly is configured to transition between a first state and a second state, wherein:
(i) in the first state, the lockout assembly is configured to permit translation of the translating member, and
(ii) in the second state, the lockout assembly is configured to prevent translation of the translating member;
wherein the method comprises:
(a) providing the lockout assembly in the first state to permit translation of the translating member, wherein in the first state the electrically powered braking feature is separated at a distance from the translating member;
(b) translating the translating member; and
(c) transitioning the lockout assembly to the second state to prevent further translation of the translating member by linearly translating the lock member of the electrically powered braking feature away from the enclosure defined by the actuator to be in contact with the translating member.

US Pat. No. 10,478,187

BIOLOGICALLY DERIVED EXTRACELLULAR MATRIX WITH INFUSED VISCOUS ABSORBABLE COPOLYMER FOR RELEASABLY ATTACHING A STAPLE BUTTRESS TO A SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

20. A surgical stapler end effector, the end effector comprising:(a) a staple cartridge, wherein the staple cartridge comprises:
(i) a plurality of staples, and
(ii) a deck, wherein the staple cartridge is operable to drive the staples through the deck;
(b) an anvil, wherein the anvil is movable from an open position toward the staple cartridge to reach a closed position, wherein the anvil includes an underside having staple forming surface configured to receive staples driven through the deck;
(c) a buttress assembly, wherein the buttress assembly comprises:
(i) a buttress body, wherein the buttress body defines a plurality of cells, and
(ii) an adhesive material, wherein the adhesive material is configured to removably secure the buttress body to the deck of the staple cartridge or the underside of the anvil, wherein at least some of the adhesive material is located in at least some of the cells; and
(d) a retainer, wherein the retainer is configured to removably hold the buttress assembly, wherein the retainer includes a plurality of projections on a surface of the retainer, wherein the projections are configured to provide focused pressure in a direction away from the surface of the retainer to discrete regions of the buttress assembly.

US Pat. No. 10,478,185

TOOL ASSEMBLY WITH MINIMAL DEAD SPACE

Covidien LP, Mansfield, ...

1. A surgical stapling device comprising:an elongate body; and
a tool assembly supported on a distal portion of the elongate body, the tool assembly including a cartridge assembly and an anvil assembly that are movable in relation to each other between spaced and approximated positions, the cartridge assembly including a staple cartridge supporting a plurality of staples, a clamp member having a body supporting a knife, and an actuation sled having a first portion and a second portion, each of the first and second portions of the actuation sled defining a cam member, the second portion of the actuation sled being physically separated and spaced from the first portion of the actuation sled to define a channel between the first and second portions, wherein in a pre-actuated state of the surgical stapling device, the clamp member is positioned within the channel between the first and second portions of the actuation sled with the knife of the clamp member positioned distally of a proximal end of the cam member of the first and second portions of the actuation sled, wherein during at least a portion of a firing stroke of the surgical stapling device, the clamp member is movable to position the knife proximally of the cam members; wherein each of the first and second portions of the actuation sled include an inner wall including a longitudinally extending portion and a transverse portion.

US Pat. No. 10,478,184

SYSTEM FOR CONTROLLING A TISSUE-STAPLING OPERATION

Boston Scientific Scimed,...

1. A method of operating an endoscopic stapler including (a) a staple member with one or more staples and (b) an anvil member, comprising:positioning the stapler within a body;
advancing a first pusher unit relative to a first fluid source of a controller operably coupled to the stapler to direct a pressurized fluid through a first conduit to relatively move the staple member and the anvil member towards one another, wherein the controller includes a sensor that measures an amount of pressurized fluid directed through the first conduit based on an amount of time a current supplied by the controller is activated; and
advancing a second pusher unit of the controller relative to a second fluid source to direct a pressurized fluid through a second conduit to eject one or more staples from the staple member.

US Pat. No. 10,478,181

CARTRIDGE LOCKOUT ARRANGEMENTS FOR ROTARY POWERED SURGICAL CUTTING AND STAPLING INSTRUMENTS

Ethicon LLC, Guaynabo, P...

1. A surgical cutting and stapling end effector, comprising:a channel configured to operably support a removable staple cartridge that includes surgical staples stored therein that are ejected from the removable staple cartridge as a sled that is movably supported therein is moved from a starting position to an ending position in the removable staple cartridge;
a rotary end effector drive shaft supported within said channel and being selectively rotatable by a source of rotary motion applied thereto; and
a firing assembly movable from a first position wherein said firing assembly is longitudinally movable through said channel and a second locked position wherein said firing assembly is prevented from moving distally through said channel, said firing assembly being biased into said first position prior to rotation of said rotary end effector drive shaft and moving to said second locked position upon rotation of said rotary end effector drive shaft unless said sled of said removable staple cartridge that has been seated in said channel is in the starting position and retainingly engages said firing assembly to thereby retain said firing assembly in said first position during further rotation of said rotary end effector drive shaft, said firing assembly comprising:
a firing body movably supported on said rotary end effector drive shaft;
a rotary advancement member in driving engagement with said rotary end effector drive shaft and in driving engagement with said firing body, said rotary advancement member being movable between said first position and said second locked position relative to said firing body; and
a biasing member between said firing body and said rotary advancement member to bias said rotary advancement member into said first position.

US Pat. No. 10,478,180

SLITTED TISSUE FIXATION DEVICES AND ASSEMBLIES FOR DEPLOYING THE SAME

EndoGastric Solutions, In...

1. A method for mounting a fastener onto a deployment wire, comprising:providing a fastener and a deployment wire, the fastener including a first member and a second member, connecting the first member to the second member by a connecting member that is not the deployment wire, only the first member having a through channel dimensioned to be slidingly received on the deployment wire and a slit configured to be made larger so that the deployment wire can be snapped onto and released from the through channel;
the slit having a first elongated edge and a second elongated edge, the first and second elongated edges being spaced apart; and
snapping the deployment wire through the slit and into the through channel by moving the first and second elongated edges farther apart to accommodate the deployment wire.

US Pat. No. 10,478,179

ABSORBABLE FASTENER FOR HERNIA MESH FIXATION

Covidien LP, Mansfield, ...

1. A mesh fastener for penetrating tissue and fixating mesh, the mesh fastener having a longitudinal axis and comprising:a head section with a distal surface and a proximal surface perpendicular to the longitudinal axis, the head section having an outer wall defining an outer diameter, the outer wall having a pair of spaced apart tool engaging flanges defining a pair of open sections and a pair of threaded sections, each open section of the pair of open sections extending from the proximal surface to the distal surface of the head section, the pair of threaded sections being located about 180° from each other, each flange of the pair of spaced apart tool engaging flanges including a single thread having a first pitch formed on an outer surface of a respective one of the pair of spaced apart tool engaging flanges, each thread extending radially to a single peak;
a threaded, truncated tissue snaring section, having a distal and a proximal end, the proximal end of which is formed on the distal surface of the head section,
the threads of the tissue snaring section, having a diameter and root diameter, and extending from the proximal end of the tissue snaring section to the distal end of the tissue snaring section, the threads of the tissue snaring section having a second pitch that is different from the first pitch; and
a sharpened tip extending distally from the tissue snaring section, a distal-most tip of the sharpened tip radially spaced from the longitudinal axis of the mesh fastener,
wherein the fastener is formed of a polymer that exhibits a young's modulus in the range of 150,000 to 2,000,000 PSI.

US Pat. No. 10,478,178

SUTURE WITH TRIM FORMED TIP

Ethicon, Inc., Somervill...

1. A monofilament suture having a formed distal tip, comprising;a suture filament having a body, proximal end and a distal end, the body of the suture having a maximum cross-sectional dimension;
a tip section on the distal end, the tip section having a configuration with an outer perimeter comprising at least first and second opposed arcuate sections joined together by opposed first and second flat or linear sections that are substantially parallel to each other, and a cross-section having a maximum dimension, wherein the maximum dimension of the cross-section of the tip section is less than the maximum cross-sectional dimension of the body of the suture;
a transition section between the suture filament body and the tip section, the transition section tapering from the suture filament body to the tip section to transition from a diameter of the suture filament body to a diameter of the tip section; and
lateral trim regions in the distal end extending through the transition section into at least a portion of the tip section, the lateral trim regions comprising connected opposed arced portions.

US Pat. No. 10,478,177

SYSTEMS AND METHODS FOR INCREASED OPERATING ROOM EFFICIENCY

SHARP FLUIDICS LLC, Hayw...

1. A needle receptacle comprising:a housing comprising a lower structure and an upper structure,
wherein the upper structure comprises an optically transmissive material and the lower structure comprises an optically transmissive material in order to view needles within a secure zone of the receptacle with backlight illumination,
wherein the upper structure has a longitudinal slot to receive a needle driver, and
wherein the secure zone comprises an elongate needle slot to receive a plurality of needles, the elongate needle slot extending between the upper structure and the lower structure, and wherein needles in the needle slot can be viewed through the upper structure with the backlight illumination through the lower structure.

US Pat. No. 10,478,176

TISSUE LIGATING DEVICE

The University of Tokyo, ...

1. A tissue ligating device used for ligating tissue, comprising:a first fixation part configured to allow a base end part of a suture thread to be fixed thereto; and
a second fixation part configured to allow insertion of the suture thread therethrough and allow to be crimped so as to newly fix a part of the suture thread, and thereby to define a loop starting from the base end part, in a state after ligation of tissue is performed,
wherein:
the second fixation part includes a back side wall part, a front side wall part, and a curved wall part turning back from the back side wall part to the front side wall part,
the back side wall part is longer than the front side wall part, and
a first part of the back side wall part farther from the curved wall part than an end part of the front side wall part far from the curved wall part has a rising surface that extends straightly towards the front side wall part and an inclined surface continuing to the rising surface and inclined or curved away from the rising surface, the inclined surface being farther away from the curved wall part than the rising surface.

US Pat. No. 10,478,174

ADAPTOR FOR SURGICAL INSTRUMENT FOR CONVERTING ROTARY INPUT TO LINEAR OUTPUT

Covidien LP, Mansfield, ...

1. An adaptor for a surgical stitching instrument, the adaptor comprising:a casing;
a cam drum disposed within the casing and defining a longitudinal axis, the cam drum being supported for rotation about the longitudinal axis and defining at least one radial cam groove about an outer surface thereof;
at least one linear driver including a first cam follower disposed in the at least one cam groove, the at least one linear driver being supported for movement between advanced and retracted positions in relation to the cam drum along an axis parallel to the longitudinal axis in response to rotation of the cam drum about the longitudinal axis, the at least one linear driver manipulating at least one drive rod of a jaw assembly of the stitching instrument; and
an articulation assembly having an articulation drum defining at least one cam surface, the articulation assembly having a drive bar with a cam follower disposed in the at least one cam surface, rotation of the articulation drum effecting advancement and retraction of the drive bar to articulate the jaw assembly of the stitching instrument.

US Pat. No. 10,478,173

MEDICAL APPARATUS AND METHOD FOR ATTACHING A SUTURE TO A BONE

1. A medical implement for attaching a suture to a bone, comprising:a handle having a proximal end for manual grasping and a distal end for engagement with said bone to which said suture is to be attached, said bone being pre-formed with a first bore, said handle extending axially from said proximal end to said distal end;
a hook extending from the distal end of the handle and configured for reception in said first bore of the bone;
a movable member resiliently coupled to said handle and urged in an axial direction of the handle toward the hook responsive to the resilient coupling, said movable member being movable to a retracted position with respect to the hook to facilitate reception of the hook into said first bore, and biased to an extended position with respect to the proximal end of the handle for clamping said handle to said bone with a resilient force at a predetermined angle with respect to said first bore;
and a manually manipulatable member coupled to said movable member for moving said movable member to said extended and retracted positions;
said handle being formed with a passageway extending longitudinally therethrough from its proximal end to its distal end, said passageway being configured for receiving a drill, for drilling a second bore through said bone at said predetermined angle with respect to said first bore and for passing through the passageway one end of a suture to traverse, and to extend past, said first bore such that said one end of the suture is accessible through said first bore for being pulled out therefrom, while the opposite end of the suture is accessible through said second bore for pulling out therefrom in order to attach the suture to said bone.

US Pat. No. 10,478,171

FLUSH ANCHOR METHOD AND APPARATUS

LITTLE ENGINE, LLC, Belm...

1. An apparatus for anchoring a tensile member to bone, comprising:an anchor, comprising:
a housing extending along a central axis between open first and second ends, and having a hollow interior;
a collet disposed in the hollow interior of the housing, the collet having a peripheral wall defining a central bore for accepting a tensile member therethrough and an exterior surface, wherein the collet is configured to be swaged around and against the tensile member;
a sleeve having a peripheral wall defining opposed interior and exterior surfaces, the sleeve disposed in the hollow interior of the housing and positioned generally axially adjacent to the collet, so as to be movable parallel to the central axis between first and second positions; and
wherein at least one of the exterior surface of the collet and the interior surface of the sleeve is tapered and the sleeve and the collet are arranged such that movement of the sleeve from the first position to the second position will cause the interior surface of the sleeve to bear against the exterior surface of the collet, causing the collet to swage radially inwards around and against the tensile member without moving axially relative to the housing or tensile member; and
an insertion instrument including:
a stem having an anchor connection mechanism;
a hollow pushrod extending through the stem and slidably movable between retracted and extended positions; and
a driving mechanism operable to move the pushrod between the retracted and extended positions.

US Pat. No. 10,478,170

T-FASTENER SUTURE DELIVERY SYSTEM

C. R. Bard, Inc., Murray...

1. A delivery device, comprising:a housing including a plurality of teeth defining a plurality of pockets on an interior side surface;
a needle extending from a distal end of the housing;
a plurality of T-fasteners, each of the T-fasteners including:
a fastener portion disposed in a lumen of the needle; and
a suture portion extending toward a proximal end of the housing; and
an ejection assembly including:
an actuator designed for reciprocal movement between a first position and a second position, wherein the fastener portion is ejected from a distal end of the needle in the second position; and
an ejector designed for incremental distal movement, the ejector including:
a plurality of teeth designed to engage the actuator; and
an ejector arm designed to engage the plurality of pockets.

US Pat. No. 10,478,168

DEVICE AND METHOD FOR TREATMENT OF INCISION OR HERNIA

LifeCell Corporation, Ma...

1. A device for treating an incision, hernia, or abdominal wall defect, comprising:an elongate element having a first longitudinal axis; and
at least one sheet connected to the elongate element along the first longitudinal axis;
wherein the at least one sheet comprises an acellular dermal tissue matrix derived from porcine dermis having a Young's modulus within a range of 49.5 MPa to 94.7 MPa.

US Pat. No. 10,478,166

LAPAROSCOPIC MORCELLATING RECEPTACLE AND METHODS OF USE

1. A morcellation receptacle system comprising:a collapsible and expandable receptacle, having a vertical axis with a lower half section with a distal area, and an upper half section with a proximal end, and a horizontal axis, configured such that when the collapsible receptacle is collapsed on its horizontal axis, it is linearly sized to fit within and through an opening between 14-20 mm in width but not when expanded in a natural open position; said receptacle comprising:
a plurality of at least three support rods positioned in a circumferential and equidistant manner around the vertical axis, or substantially so, having distal ends coupled to the distal area of the receptacle and having proximal ends extending proximally and laterally away from the distal area and configured to have natural spring tension such that the support rods are expanded, away from each other in a natural, open, position, and move towards each other on the horizontal axis when the receptacle is collapsing and move away from each other on the horizontal axis when the receptacle is opening,
a flexible liner that is water resistant, low-friction, tear-resistant, and made of material different from the support rods, having a thickness between 0.05-0.15 mm, wrapped along the support rods such as to define a bag with a closed end at the distal area;
and a cover made of a thin flexible material that is permanently attached to a perimeter of the proximal end of the receptacle, such that the cover and the perimeter of the proximal end of the receptacle are expandable and collapsible to fit through the 14 to 20 mm opening and the cover establishes a surface area having a plurality of premade holes configured to allow a trocar sleeve to pass through into the receptacle along the vertical axis when the receptacle is in a natural expanded position, and wherein the cover comprises a substantially central opening configured to be releasably closable, such that at least 75% of area of the substantially central opening is occluded, while the perimeter of the proximal end of the receptacle is maintained in its expanded natural, open position and the plurality of premade holes individually remain accessible for the trocar sleeve to pass through into the receptacle along the vertical axis.

US Pat. No. 10,478,165

MULTI-UTILITY SURGICAL INSTRUMENT

KATALYST SURGICAL, LLC, ...

1. An instrument comprising:a handle having a handle distal end and a handle proximal end;
a nosecone having a nosecone distal end and a nosecone proximal end wherein the nosecone is connected to the handle;
a hypodermic tube having a hypodermic tube distal end and a hypodermic tube proximal end wherein the hypodermic tube proximal end is disposed in the nosecone;
an end plug having an end plug distal end and an end plug proximal end wherein the end plug is at least partially disposed in the handle; and
an interface taper of the end plug configured to interface with a syringe wherein the syringe is configured to flush a fluid through the instrument and expel the fluid from the hypodermic tube distal end.

US Pat. No. 10,478,162

SYSTEMS AND METHODS FOR DISPLAY OF PATHOLOGICAL DATA IN AN IMAGE GUIDED PROCEDURE

INTUITIVE SURGICAL OPERAT...

1. A method comprising:displaying, in a first region of a display screen, an image of a patient anatomy for guiding a medical instrument to a deployment location during a medical procedure;
recording a plurality of sample identifiers, wherein each sample identifier of the plurality of sample identifiers is associated with a corresponding tissue sample of a plurality of tissue samples;
recording a plurality of location stamps, wherein each location stamp of the plurality of location stamps indicates a location in the patient anatomy of a corresponding tissue sample of the plurality of tissue samples;
receiving tissue sample pathology information for each tissue sample in the plurality of tissue samples; and
displaying, in a table in a second region of the display screen, the plurality of sample identifiers, the plurality of location stamps, and the tissue sample pathology information for each tissue sample during the medical procedure.

US Pat. No. 10,478,161

TISSUE CUTTING MEMBER FOR A BIOPSY DEVICE

SenoRx, Inc., Franklin L...

1. A method for forming a tissue cutting member to separate a tissue specimen from a target site within a patient's body, comprising:providing a distal tubular portion including a side wall defining a lumen, a longitudinal axis, and a flared distal section;
configuring the flared distal section to include an inclined distal tip at a distal end of the side wall and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture, the inclined distal tip having a beveled front face with a leading cutting edge and a trailing cutting edge, the outwardly flared distal tubular portion being outwardly flared in a distal direction to the leading cutting edge;
providing a single longitudinally oriented opening in the side wall in the flared distal section which radially opens to the lumen, the single longitudinally oriented opening having an open distal end and extending from a closed proximal end to the open distal end; and
providing a relief opening at the closed proximal end, the relief opening having a transverse dimension larger than a transverse dimension of the single longitudinally oriented opening adjacent the relief opening, the single longitudinally oriented opening diverging from the closed proximal end to intersect the trailing cutting edge of the beveled front face of the inclined distal tip of the distal tubular portion and facilitating formation of the outwardly flared distal tubular portion.

US Pat. No. 10,478,160

TECHNOLOGIES FOR CARTILAGE HARVESTING

1. A method comprising:coupling a cutting head onto an actuator, wherein the cutting head is coupled to the actuator via a shaft, wherein the shaft includes a first end portion, a second end portion, and a disc portion, wherein the disc portion is positioned between the first end portion and the second end portion, wherein the first end portion is coupled to the actuator such that the first portion is not visible external to the actuator, wherein the disc portion engages the actuator such that the disc portion is visible external to the actuator, wherein the second end portion is fastened to the cutting head;
applying a force to the cutting head via the actuator; and
cutting a cartilage with the cutting head based on the force.

US Pat. No. 10,478,159

BIOPSY NEEDLE DESIGN

3DBiopsy, Inc., Aurora, ...

1. An apparatus, comprising:a cannula, comprising:
a body extending between a first end and a second end, the body having a first side and an opposite second side; and
a leading edge formed by the first end, the leading edge extending along a first plane, the first plane extending between the first side and second side, the first plane forming a leading edge angle between the intersection of the first side and the first plane;
a mandrel, comprising:
a body extending between a first end and a second end along a central longitudinal axis;
a notch formed by the body, the notch forming a bed extending between the first end and the second end;
a first sample region formed by the bed, the first sample region, comprising:
a first plurality of ridges, wherein each of the first plurality of ridges comprises:
a flank extending from the bed toward the mandrel body second end, the flank terminating at a crest; and
a concave slope descending from the crest;
a second sample region formed by the bed, the second sample region comprising:
a second plurality of ridges, wherein each of the second plurality of ridges comprises:
a flank extending from the bed toward the mandrel body second end, the flank terminating in a crest; and
a concave slope descending from the crest;
a deck disposed between the first plurality of ridges and the second plurality of ridges.

US Pat. No. 10,478,157

METHODS FOR DRUG DELIVERY

PRESAGE BIOSCIENCES, INC....

1. A method of delivering one or more agents to a solid tumor of a subject, comprising:(a) inserting one or more needles of a needle array device into said solid tumor, said needle array device comprising five or more needles and one or more agents; and
(b) injecting said one or more agents into said solid tumor via said one or more needles of said needle array device while simultaneously withdrawing said one or more needles from said solid tumor.

US Pat. No. 10,478,156

IMAGING APPARATUS FOR DIAGNOSIS, METHOD OF CONTROLLING THE SAME, PROGRAM, AND COMPUTER READABLE STORAGE MEDIUM

TERUMO KABUSHIKI KAISHA, ...

1. An imaging apparatus for diagnosis accommodating an imaging core which has an optical transceiver for transmitting light from a light source toward a vascular tissue and for receiving reflected light from the vascular tissue, and reconstructing a blood vessel image based on interference light data obtained by converting into an electric signal interference light in which measurement light obtained by rotating the imaging core by using a catheter which has an open hole at a distal end portion and reference light separated from the light from the light source are synthesized, the imaging apparatus for diagnosis comprising:line data generation means for generating line data in a radial direction from a rotary center position of the imaging core based on the interference light data;
determination means for determining whether or not a foreign substance other than a predetermined liquid enters between the imaging core and an inner surface of the catheter based on distribution of signal strength values in the line data which is generated by the line data generation means; and
display means for displaying a message which indicates that entrance of the foreign substance is detected in a case where a determination result of the determination means indicates the entrance of the foreign substance.

US Pat. No. 10,478,155

ULTRASONIC DEVICE, PROBE, ELECTRONIC INSTRUMENT, DIAGNOSTIC DEVICE, AND PROCESSING DEVICE

Seiko Epson Corporation, ...

13. An ultrasonic device comprising:a piezoelectric element group including a plurality of piezoelectric elements, the piezoelectric elements forming “N” columns arranged along a second direction intersecting with a first direction with each of the “N” columns including a plurality of the piezoelectric elements arranged along the first direction, “N” being a natural number that is equal to or more than 2, each of the piezoelectric elements including a cavity section disposed in a substrate, a membrane covering the cavity section, a first electrode disposed on the membrane, a piezoelectric body disposed on the first electrode, and a second electrode disposed on the piezoelectric body;
a first to an Nth driving electrode lines arranged along the first direction;
a first terminal from which a first driving signal for driving the piezoelectric elements, which is a voltage having an amplitude, is supplied to the piezoelectric elements; and
a second terminal from which a second driving signal for driving the piezoelectric elements, which is a voltage having an amplitude, is supplied to the piezoelectric elements; and
a driving signal output circuit configured to output the first and second driving signals to the first and second terminals, respectively,
an ith driving electrode line among the first to the Nth driving electrode lines being connected to the piezoelectric elements constituting an ith column among the “N” columns, with “i” being a natural number that is equal to or less than “N”, the first terminal being connected to one end of the ith driving electrode line, the second terminal being connected to the other end of the ith driving electrode line,
the driving signal output circuit having an output amplifier, a first variable resistance that is configured to adjust the amplitude of the voltage of the first driving signal and is arranged between the output amplifier and the first terminal, and a second variable resistance that is configured to adjust the amplitude of the voltage of the second driving signal and is disposed between the output amplifier and the second terminal.

US Pat. No. 10,478,154

ULTRASOUND SENSOR ELEMENT, ULTRASOUND SENSOR ARRAY ASSEMBLY, ULTRASOUND TRANSMIT SENSOR ELEMENT, IMAGING DEVICE, ULTRASOUND TRANSDUCER, AND METHOD OF PERFORMING AN ULTRASOUND SCAN

Sharp Kabushiki Kaisha, ...

1. An ultrasound sensor array assembly comprising a two dimensional array of ultrasound sensor elements, each sensor element in the two dimensional array of ultrasound sensor elements comprising:an ultrasound transducer,
a transmit circuit configured to provide an electrical signal to the transducer for output of an ultrasound signal; and
a receive circuit configured to receive an electrical signal from the transducer, based on a received reflected ultrasound signal,
wherein the transmit and receive circuits each comprise one or more thin film transistors;
the sensor array assembly further comprising:
a plurality of transmit delay circuits, wherein each transmit delay circuit is in electrical communication with each sensor element in a row of the array of sensor elements, and wherein the transmit delay circuits are configured to delay a transmit signal to the sensor elements in each row for steering a beam of emitted ultrasound; and
a plurality of receive delay circuits, wherein each receive delay circuit is in electrical communication with each sensor element in a column of the array of sensor elements, and wherein the receive delay circuits are configured to delay a receive signal from the sensor elements in each column for steering the beam of received reflected ultrasound;
wherein the plurality of transmit delay circuits are incorporated into a first driver circuit, and the plurality of receive delay circuits are incorporated into a second driver circuit, and the first and second driver circuits are located external and adjacent to the two dimensional array of ultrasound sensor elements.

US Pat. No. 10,478,152

ENDOSCOPE APPARATUS

FUJIFILM Corporation, To...

1. An endoscope apparatus comprising:an insertion part configured to be inserted into a body; an operation part continuously provided on a proximal end side of the insertion part;
a forceps elevator which is erectably provided to a distal end part of the insertion part, has an erecting motion range from a minimum angular position where the forceps elevator is most reclined to a maximum angular position where the forceps elevator is most erected, and is configured to guide a treatment tool led out from the distal end part;
an operation wire coupled at one end with the forceps elevator and which is inserted into the insertion part; and
an erecting operation lever provided to the operation part, coupled to the other end of the operation wire, and configured to operate the operation wire to erect the forceps elevator;
a first elevator restricting surface configured to restrict the forceps elevator to the minimum angular position in the erecting motion range;
a second elevator restricting surface configured to restrict the forceps elevator to the maximum angular position in the erecting motion range;
a first operation lever restricting surface provided in the operation part, and configured to restrict the erecting operation lever to one end position on a side the forceps elevator is reclined in an entire operating range where the erecting operation lever is operable; and
a second operation lever restricting surface provided in the operation part, and configured to restrict the erecting operation lever to the other end position on a side the forceps elevator is erected in the entire operating range where the erecting operation lever is operable,
wherein an index is disposed on the operation part between the operation part and the erecting operation lever such that the index is entirely shielded by the erecting operation lever when the forceps elevator is in the minimum angular position, and such that the index is exposed when the forceps elevator is in a position in which the forceps elevator is erected from the minimum angular position,
wherein, when an intermediate position is defined between the one end position and the other end position in the entire operating range of the erecting operation lever, the erecting operation lever has: a first operating range being a range between the one end position and the intermediate position; and a second operating range being a range between the intermediate position and the other end position,
wherein, the operation wire has a length such that the forceps elevator is movable from the minimum angular position to the maximum angular position when the erecting operation lever is operated from the one end position to the intermediate position in the first operating range in a state where the treatment tool is not led out from the distal end part,
wherein, the second operating range is a range enabling to position the forceps elevator at the maximum angular position by operating the erecting operation lever from the intermediate position toward the other end position, when the forceps elevator is positioned at an angular position smaller than the maximum angular position even though the erecting operation lever is operated and reaches the intermediate position in a state where the treatment tool is led out from the distal end part.

US Pat. No. 10,478,151

SYSTEM AND METHOD FOR AUTOMATED MONITORING OF FETAL HEAD DESCENT DURING LABOR

GENERAL ELECTRIC COMPANY,...

1. A method for automatically monitoring fetal head descent in a birth canal, comprising:acquiring, via at least one processor, one or more transperineal ultrasound images corresponding to a birth canal of a patient in labor such that the one or more transperineal ultrasound images comprise at least two structures of interest;
segmenting, via the at least one processor, each of the one or more transperineal ultrasound images into a plurality of neighborhood components;
determining, via the at least one processor, a cost function corresponding to each neighborhood component in the plurality of neighborhood components in each of the one or more transperineal ultrasound images;
identifying, via the at least one processor, the at least two structures of interest in each of the one or more transperineal ultrasound images based on the cost function, wherein the at least two structures of interest comprise a pubic ramus and a fetal head;
measuring, via the at least one processor, an angle of progression between a first line passing through the pubic ramus and a second line extending from an inferior apex of the pubic ramus and tangentially intersecting a contour of the fetal skull;
determining, via the at least one processor, the fetal head descent in the birth canal based on the angle of progression to automatically monitor progression of the fetal head in the birth canal of the patient during labor; and
visualizing the one or more transperineal ultrasound images, the pubic ramus, the fetal head, a tangent point on the fetal head, the angle of progression, the fetal head descent, or combinations thereof on a display, wherein at least the angle of progression is overlaid on the one or more transperineal ultrasound images,
wherein the steps of acquiring the one or more transperineal ultrasound images, segmenting each of the one or more transperineal ultrasound images, determining the cost function, identifying the at least two structures of interest, measuring the angle of progression, determining the fetal head descent, and visualizing are automated steps.

US Pat. No. 10,478,150

MEDICO—SURGICAL DEVICES

The Cooper Companies Glob...

1. An embryo replacement catheter comprising:a hub; and
a shaft attached to the hub, the shaft having a bore extending therethrough, the shaft comprising a wall of a transparent plastic material with gas bubbles incorporated therein,
wherein the gas bubbles extend through a major part of a thickness of the wall of the shaft, and the gas bubbles have a density and size to enable visibility of the catheter under ultrasound imaging and to enable an embryo within the bore of the shaft to be viewed by a naked eye of a user.

US Pat. No. 10,478,148

SELF-CALIBRATING PROJECTION GEOMETRY FOR VOLUMETRIC IMAGE RECONSTRUCTION

The Johns Hopkins Univers...

1. A method for self-calibrating projection geometry for a volumetric image reconstruction comprising:selecting a prior volumetric representation of a patient;
dividing a cone-beam computed tomography (CBCT) scan from a CBCT scanner to be self-calibrated into a number of projections;
selecting a projection from the number of projections;
registering the projection to the prior volumetric representation in order to determine a 9-degree-of freedom geometric calibration of the selected projection;
applying the 9-degree-of-freedom geometric calibration of the selected projection;
generating a projection matrix from the 9-degree-of-freedom geometric calibration of the selected projection; and
generating and displaying a three-dimensional, volumetric reconstruction of the CBCT scan using a plurality of the projection matrix for self-calibration of the CBCT scanner.

US Pat. No. 10,478,147

CALIBRATION APPARATUS AND METHOD FOR COMPUTED TOMOGRAPHY

NIKON METROLOGY NV, Leuv...

1. A method of calibrating a radiographic system comprising a source and a detector, the method comprising:providing a calibration object comprising a plurality of markers,
rotating the calibration object relative to the source and/or detector,
acquiring a plurality of radiographic images of the calibration object,
identifying the plurality of markers in the plurality of images,
deriving an elliptical path for each of the plurality of markers using said plurality of images by
assigning a nominal value representing a distance between the source and an axis of rotation of each said marker, and
determining complete geometrical parameters of the system apart from said nominal distance value using the radiographic images and said nominal distance value,
where said complete geometrical parameters are seven parameters including two parameters specifying a principal point, one parameter specifying a focal length, two parameters specifying the orientation of the axis of rotation and two parameters specifying the position of the axis of rotation, and using said elliptical paths to determine geometrical parameters of the system.

US Pat. No. 10,478,144

X-RAY IMAGING APPARATUS AND IMAGING METHOD USING THE SAME

SHIMADZU CORPORATION, Ky...

1. An X-ray imaging apparatus, comprising:an X-ray irradiation detection element including an X-ray irradiation element that irradiates an X-ray to a subject and an X-ray detection element that detects said X-ray transmitting through said subject;
a table that is enabled to load said subject on a loading plane;
a driving element that relatively moves said table relative to said X-ray irradiation detection element; and
a control element that controls a to move of at least one of said table and said X-ray irradiation detection element by said driving element based on a pre-registered pathway information when imaging said subject;
wherein said control element acquires an information as a representative point that is relative to a location at which said table and said X-ray irradiation detection element suspend moving relative to each other y based on either that a relative moving between said table and said X-ray irradiation element suspends, or that once the relative moving between said table and said X-ray irradiation detection element is suspended and then said relative moving between said table and said X-ray irradiation detection element restarts after said table and said X-ray irradiation detection element are relatively moved by at least one of a manual element and or a driving element, and registers said pathway information based on said acquired representative point.

US Pat. No. 10,478,143

SYSTEM AND METHOD OF GENERATING AND UPDATNG A THREE DIMENSIONAL MODEL OF A LUMINAL NETWORK

COVIDIEN LP, Mansfield, ...

1. A method of updating a model of a luminal network, comprising:generating 3D image data including fiducial markers disposed at a first location using images captured in a first imaging of a target;
generating 2D image data including the fiducial markers disposed at a second location using images captured in a second imaging of the target, the second imaging of the target including imaging of the target from a first viewpoint and imaging the target from a second viewpoint, the first and second viewpoints oriented at a known angle relative to each other;
determining the second location of the fiducial markers in 3D space based on the second location of the fiducial markers within the 2D image data of the first viewpoint, the second location of the fiducial markers within the 2D image data of the second viewpoint, and the known angle;
comparing the first location of the fiducial markers in the 3D image data to the second location of the fiducial markers in 3D space;
determining a difference between the first location of the fiducial markers in the 3D image data and the second location of the fiducial markers in 3D space based on the comparison;
updating the 3D image data generated using images captured in the first imaging with the determined second location of the fiducial markers in 3D space based on the determined difference;
displaying the updated 3D image data including the fiducial markers disposed at the second location of the fiducial markers in 3D space;
determining movement distances between the second location of the fiducial markers in 3D space and the first location of the fiducial markers in the 3D image data from the first imaging;
determining which of the movement distances exceeds a threshold; and
registering the 3D image data generated using images captured in the first imaging with the determined second location of the fiducial markers in 3D space, wherein the registering excludes the second location in 3D space of the fiducial marker corresponding to movement distances that exceed the threshold.

US Pat. No. 10,478,139

COMPUTED TOMOGRAPHY SYSTEM HAVING COOLING SYSTEM

Samsung Electronics Co., ...

1. A cooling system of a computed tomography (CT) system, comprising:a gantry having a bore therein; and
a table that moves into and out of the bore of the gantry,
wherein the gantry comprises a part box mounted therein, and blade elements that are formed in regions of the part box are arranged to control an air flow inside the gantry,
wherein the part box is an external housing for a part,
wherein the part comprises one or more of an X-ray generator, an X-ray detector, a data acquisition system (DAS), a power supplier, a heat exchanger (HX), an high voltage generator (HVG),or a wireless transducer for each part box,
wherein the part box comprises an inlet hole and an exhaust hole arranged in one or more surfaces of the part box, and the blade elements are fixed on an inner surface of the part box,
wherein one edge of each of the blade elements is exposed at a surface of the part box through the inlet hole, and another edge of each of the blade elements extends toward an inner side of the inlet hole of the part box, and
wherein an extended portion between the one edge and the another edge in each of the blade elements is not visible through the inlet hole of the part box.

US Pat. No. 10,478,136

RADIOLOGICAL DOSING SYSTEM AND METHOD

Certa Dose, Inc.

1. A method of administering radiation to a patient, the method comprising:receiving, at a processor associated with a radiation device, information indicating that a patient is associated with a coded region included among a plurality of coded regions wherein each of the plurality of coded regions corresponds to one or more values of a physical characteristic wherein the processor determines a patient size;
receiving, at the processor, a radiation location for the patient;
determining, at the processor and based on the patient size, a safe range of radiation for the patient;
correlating, at the processor, the coded region and the radiation location with a dose of radiation; and
applying the dose of radiation to the patient at the radiation location.

US Pat. No. 10,478,135

UROLOGY TABLE WITH TILTABLE X-RAY TUBE

STORZ MEDICAL AG, Tagerw...

1. A urological device oriented with respect to a Cartesian system of coordinates defined by an x-axis, a y-axis, and a z-axis, the device comprising:a patient table having a longitudinal side aligned with the x-axis, and a broad side aligned with the y-axis, wherein the z-axis extends above and below the patient table in a direction transverse to the patient table;
an X-ray source mounted above the patient table and configured to emit a beam of X-ray radiation directed to the patient table,
an X-ray detector mounted below the patient table and configured to detect the X-ray radiation that has been emitted by the X-ray source and that has passed through a patient on the patient table,
an X-ray source linear drive configured to move the X-ray source parallel to the y-axis,
a pivot mechanism configured to pivot the X-ray source about a first pivot axis and in a plane parallel to the y-axis and z-axis,
an X-ray detector linear drive configured to move the X-ray detector parallel to the y-axis without tilting the X-ray detector,
and
a control unit operably connected with the X-ray detector and X-ray source and configured to coordinate
(i) a first movement of the X-ray source in a first direction
with
a unidirectional second movement of the X-ray detector in a second direction that is opposite to the first direction,
and
(ii) pivoting of the X-ray source to position the X-ray source for directing the X-ray beam to the detector at different angles,
such as to have a center of the X-ray beam aligned with a center of the X-ray detector at each position of the X-ray detector.

US Pat. No. 10,478,134

SYSTEMS AND METHODS FOR IMPROVED DIAGNOSTICS FOR NUCLEAR MEDICINE IMAGING

GENERAL ELECTRIC COMPANY,...

1. A method comprising:defining an uncertainty model of a medical imaging system, wherein the uncertainty model is based on a natural-statistics distribution of the medical imaging system;
acquiring image data of a patient from the medical imaging system;
calculating an uncertainty map of the patient based on the uncertainty model and the image data, wherein the uncertainty map represents a collection of realizations that are generated based on the image data and the uncertainty model; and
applying a classification or ranking algorithm to the image data and the uncertainty map to calculate image data classification or ranking of the patient including confidence values,
wherein the realizations are based on simulations of selections from the uncertainty model, the simulations automatically randomize parameters of the medical imaging system to select different image voxel values.

US Pat. No. 10,478,128

HEART RATE DETECTION ARCHITECTURE

PIXART IMAGING INC., Hsi...

13. A heart rate detection device, configured to receive a photoplethysmography (PPG) raw data from a PPG detector and a microelectromechanical systems (MEMS) raw data from a MEMS accelerometer, the heart rate detection device comprising:a PPG hardware module configured to receive the PPG raw data, the PPG hardware module comprising:
a first bandpass filter configured to filter the PPG raw data;
a first conversion module configured to convert the filtered PPG raw data to PPG spectrum values and PPG frequency index; and
a first peak extraction module configured to search PPG peak spectrum values among the PPG spectrum values, and output the PPG peak spectrum values and the PPG frequency index;
a MEMS hardware module configured to receive the MEMS raw data, the MEMS hardware module comprising:
a second bandpass filter configured to filter the MEMS raw data;
a second conversion module configured to convert the filtered MEMS raw data to MEMS spectrum values and MEMS frequency index; and
a second peak extraction module configured to search a MEMS peak spectrum value among the MEMS spectrum values, and output the MEMS peak spectrum values and the MEMS frequency index; and
a microcontroller unit (MCU), electrically coupled to the PPG hardware module and the MEMS hardware module, and configured to estimate a heart rate according to the PPG peak spectrum values, the PPG frequency index, the MEMS peak spectrum values and the MEMS frequency index by
determining a reference index according to a frequency index corresponding to the MEMS peak spectrum value in the MEMS spectrum values,
determining a denoising range according to the reference index,
removing the PPG spectrum values in the PPG spectrum values corresponding to the denoising range to generate denoised PPG frequency data, and
calculating the heart rate according to a PPG peak spectrum value of the denoised PPG frequency data,
wherein the PPG hardware module outputs the PPG peak spectrum values as well as the PPG frequency index and the MEMS hardware module outputs the MEMS peak spectrum value as well as the MEMS frequency index without MCU operation to share loading of the MCU, and
wherein the estimated heart rate is configured to be shown on a display.

US Pat. No. 10,478,127

APPARATUSES, METHODS, PROCESSES, AND SYSTEMS RELATED TO SIGNIFICANT DETRIMENTAL CHANGES IN HEALTH PARAMETERS AND ACTIVATING LIFESAVING MEASURES

Sherlock Solutions, LLC, ...

54. A system comprising:a biometric apparatus including a biometric sensor wearable by a user and situationally calibratable based on a physically-measured value of said user measured by said system during a movement of said user, said biometric sensor configured to measure biometric data from said user and generate one or more processed signals based on said biometric data; and
at least one primary processor in communication with said biometric sensor, said at least one primary processor receiving said one or more processed signals, said at least one primary processor determining whether said user has experienced a physiological change based on one or more changes in at least one of a QRS complex or a Peak-Peak interval, said at least one primary processor determining whether said physiological change is a detrimental change or a not detrimental change based on a comparison of one or more health parameters generated based on said one or more processed signals, said at least one primary processor determining an action based on whether said physiological change is said detrimental change or said not detrimental change, said action including automatically notifying at least one of said user, an emergency medical system, or a remote device identifying whether said physiological change is said detrimental change or said not detrimental change.

US Pat. No. 10,478,125

SYSTEMS AND METHODS FOR FLUSHING AN ASSESSMENT CATHETER

Pulmonx Corporation, Red...

1. A pulmonary diagnostic system, comprising:a pulmonary catheter configured to be introduced transtracheally into a lung passageway of a lung segment in a patient, wherein the pulmonary catheter comprises a distal end and a proximal end with a lumen disposed in-between; and
a flushing unit comprising:
an intake port connectable to a gas source;
a pressure regulator distal to the intake port configured to regulate the pressure and flow of a clearing gas from the gas source into the flushing unit;
a first gas restrictive element;
a fixed volume gas chamber between the intake port and the first gas restrictive element, wherein the gas chamber is configured to store a volume of the clearing gas and act as a flush capacitor, and wherein the first gas restrictive element is configured to regulate delivery of the clearing gas from the gas chamber; and
a control unit configured to control a state of the first gas restrictive element;
wherein the flushing unit is configured to deliver the clearing gas to the lumen of the pulmonary catheter and out the distal end into the lung passageway with sufficient force to remove debris from the lumen while the distal end is within the lung passageway of the lung segment in the patient.

US Pat. No. 10,478,124

PRESSURE SENSOR TO DETECT BODY SOUNDS

Cardiac Pacemakers, Inc.,...

1. A system, comprising:a pressure sensor configured to receive physiologic information from a patient; and
a control circuit, coupled to the pressure sensor, configured to receive information from the pressure sensor, and to control a state of the pressure sensor, wherein the control circuit is configured to:
detect pressure information from the patient using the physiologic information received by the pressure sensor in a first state; and
detect body sound information from the patient using the physiologic information received by the pressure sensor in a second state.

US Pat. No. 10,478,123

ELASTIC SENSOR FOR MEASURING VITAL PARAMETERS IN THE AUDITORY CANAL

Cosinuss GmbH, Munich (D...

1. A sensor for measuring a vital parameter in the auditory canal (8) of a person or an animal, comprising:a sensor element fixture (2), which is positionable at least partially in the auditory canal (8),
a sensor element (1), which is connectable to the sensor element fixture (2) and is positionable at least partially in the auditory canal (8), and
a positioning element (3), suitable for positioning the sensor element fixture (2) in the auditory canal (8), wherein at least one end of the positioning element (3) is connectable to the sensor element fixture (2),
wherein the position of the sensor element (1) within the auditory canal (8) is determined by the insertion depth of the sensor element fixture (2) in the auditory canal (8), and
wherein the positioning element (3) exhibits a suitable shape relating to the anatomy of the interior face of the auricle, and is suitable for pushing the sensor element fixture (2) into the interior of the auditory canal such that the sensor is held firmly and a continuous measurement of the vital parameter occurs in the auditory canal (8) characterized in that
the sensor element (1), the sensor element fixture (2) and the positioning element (3) are arranged at least partially in a housing (4) and the housing (4) is adaptable to the anatomy of at least part of the head of the person or the animal, wherein the housing (4) is at least partially elastic, the housing (4) is rotatable and/or size adjustable, the housing (4) comprises a piston and a guide wherein the piston is at least partially aligned in the guide, the piston and/or the guide are arranged with a material comprising a plastic, a rubber, a silicone and/or an elastomer such that they may be pulled apart in the 0° position and such that a rotation of up to ?120° or +120° results in a deadlock, wherein the 0° position lies in a plane parallel to the sagittal plane of the head.

US Pat. No. 10,478,122

MEASUREMENT METHOD AND MEASUREMENT DEVICE FOR BROWN ADIPOSE TISSUE

TOKYO MEDICAL UNIVERSITY,...

1. A measurement method for brown adipose tissue, comprising:a light input step of inputting near-infrared light from a light input unit into a measurement target portion;
a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit;
a calculation step of measuring any one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit;
a defining step in which an index value for a brown adipose tissue amount is defined as the any one value measured; and
a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

US Pat. No. 10,478,121

DEVICE AND METHOD FOR DETERMINING AN INCORRECT POSITIONING IN THE ALIGNMENT OF PROSTHESES

1. A method for determining positions for alignment of a prosthetic foot relative to a lower leg tube as part of an alignment of a lower extremity device, comprising:establishing, using sensor data measured by at least one inertial sensor connected to the lower extremity device, over at least one gait cycle for a treated extremity, at least one of inertial measurement data and variables derived from the inertial measurement data for the treated extremity, the inertial measurement data comprising absolute angles of a lower leg and a thigh of the treated extremity;
determining a knee angle of the lower leg and the thigh from the absolute angles of the lower leg and thigh;
comparing the inertial measurement data and the knee angle with intended values;
determining positions for alignment of the prosthetic foot relative to the lower leg tube based on the comparing.

US Pat. No. 10,478,120

MRI-GUIDED INTRAARTERIAL CATHETER-BASED METHOD FOR PREDICTING TERRITORY OF LOCAL BLOOD BRAIN BARRIER OPENING

The Johns Hopkins Univers...

1. A method of administering a therapeutic agent directly to the brain parenchyma through a compromised region of the blood-brain barrier in a subject having a brain disorder, comprising:disrupting the blood-brain barrier (BBB) at an isolated region by locally administering an effective amount of a hyperosmolar agent at said region using a catheter,
locating an opening in the BBB using non-invasive MR (magnetic resonance) imaging with a contrast agent administered at said isolated region, and
administering a therapeutically effective amount of a therapeutic agent at the located opening in the BBB.

US Pat. No. 10,478,119

SYSTEM AND METHOD FOR DRUG DOSAGE MEDICAMENT REGIME ADHERENCE MONITORING

1. A method for oral drug dosage medicament regime adherence monitoring comprising:creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs,
loading the plurality of oral drugs into a cartridge of an oral drug dispensing device;
providing a patient wearable vital sign monitoring device for being worn by the patient,
associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime, wherein, for at least one medicament interval, the method comprises:
alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device;
obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device;
detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device;
ascertaining the proximity of the patient wearable vital sign monitoring device and the oral drug dispensing device at substantially the same time as the detecting of the dispensing of the oral drug from the cartridge;
obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device, and
comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug.

US Pat. No. 10,478,118

METHOD AND DEVICE FOR SLEEP ANALYSIS

Cleveland Medical Devices...

1. A method of remote sleep analysis and diagnosis comprising the steps of:a) providing a patient with a portable patient interface box adapted to be worn by the patient and a nasal cannula or a facemask, a respiratory effort belt and a fingertip pulse oximeter, the patient interface box comprising a battery, at least one kinetic sensor, a nonvolatile digital memory, first and second pressure transducers, a first air port for connecting the nasal cannula or the facemask to the first pressure transducer, a second air port for connecting the respiratory effort belt to the second pressure transducer, and a releasable connector sensor input to electrically connect and disconnect the fingertip pulse oximeter, the nasal cannula or facemask for measuring airflow of the patient, the respiratory effort belt for measuring respiratory effort of the patient, the kinetic sensor for measuring body position or orientation, and the fingertip pulse oximeter for measuring oxygenation of the patient;
b) applying and connecting the nasal cannula or facemask, the respiratory effort belt and the fingertip pulse oximeter to the patient, and further the patient interface box to the patient;
c) measuring and collecting data from the sensors through the patient interface box of the airflow, respiratory effort, body position or orientation and oxygenation of the patient in a remote sleep location from the sleep unit or lab while the patient is attempting to sleep;
d) digitizing and storing the collected data from the patient in the nonvolatile digital memory of the patient interface box;
e) to the sleep analysis unit or lab or to a database accessible to individuals from the sleep analysis unit or lab;
f) providing a computer or processor for analyzing the transferred collected data to identify and draw attention to physiological or technological events in the data indicative of a sleeping disorder; and
g) further analyzing at a minimum the transferred collected data and/or the physiological or technological events in the data at the sleep analysis unit or lab, or at a location remote from the remote sleep location to determine whether the patient suffers from a sleeping disorder.

US Pat. No. 10,478,116

METHODS AND SYSTEMS FOR FEEDING READINESS DIAGNOSIS

University of Florida Res...

1. A method for diagnosing a digestion condition of a subject, the method comprising:obtaining electrogastrogram (EGG), bowel sound, and Near Infrared Spectroscopy (NIRS) signals from an EGG sensor, acoustic sensor and NIRS sensor, respectively, positioned about an abdominal region of a subject;
removing artifacts from the signals to obtain conditioned signal data; and
determining a digestion condition of the subject based at least in part upon the conditioned signal data, wherein determining the digestion condition of the subject comprises identifying an abnormal digestion condition or the location or severity thereof.

US Pat. No. 10,478,114

BRAIN DYSFUNCTION ASSESSMENT METHOD, BRAIN DYSFUNCTION ASSESSMENT DEVICE, AND PROGRAM THEREOF

MAXELL, LTD., Kyoto (JP)...

1. A measurement method for cerebral dysfunction evaluation, the method comprising:providing a subject with a touch enabled computer, wherein the touch enabled computer includes one or more sensors that measure a position of a touch gesture by a first hand or a second hand of the subject;
acquiring, using the one or more sensors, a response time and position accuracy for a plurality of prescribed touch gestures performed by the subject, where the response time and the position accuracy for each of the plurality of prescribed touch gestures are acquired by:
displaying, using the display, a target with a known position on the display,
detecting, using the one or more sensors, a touch gesture performed in response to the displaying,
determining, by a processor of the touch enabled computer, the position of the touch gesture detected,
calculating, by the processor, an elapsed time from the displaying to the detecting as the response time, and
calculating, by the processor, a difference between the known position and the position of the touch gesture performed in response to the displaying as the position accuracy; and
generating evaluation data for cerebral dysfunction evaluation based on a correlation between the response time and the position accuracy for the plurality of prescribed touch gestures performed by the subject.

US Pat. No. 10,478,111

SYSTEMS FOR SPEECH-BASED ASSESSMENT OF A PATIENT'S STATE-OF-MIND

SRI International, Menlo...

1. A computer-implemented method of improving output of a speech-based state-of-mind detection system, the method comprising:receiving, using the speech-based state-of-mind detection system, a speech pattern collected from a patient;
determining, using the speech-based state-of-mind detection system, at least one feature of the collected speech pattern;
determining, using the speech-based state-of-mind detection system, a presence or absence of a state-of-mind of the patient using a first distribution of a non-lexical speech feature computed over a first time interval in which speech of the patient is collected during a session and a second distribution of the non-lexical speech feature computed over a second time interval in which speech of the patient is collected during the session to indicate a change in the patient from a first state-of-mind to a second state-state-of-mind as a result of the session;
wherein the state-of-mind is defined by a clinical protocol; and
outputting, by the speech-based state-of-mind detection system, the presence or absence of the state-of-mind to the patient, a clinical expert, or both the patient and the clinical expert.

US Pat. No. 10,478,108

ANALYTE MONITORING DEVICE AND METHODS OF USE

Abbott Diabetes Care Inc....

1. A physiological monitoring system, comprising:an analyte sensor to generate signals corresponding to monitored analyte level in bodily fluid under a skin surface of a user;
a motion detector to monitor an activity level of the user corresponding to a completed exercise activity by the user;
a processor operatively coupled to the analyte sensor and the motion detector to determine a previously monitored variation in the analyte level monitored by the analyte sensor based on the monitored activity level of the user, to receive a user-determined bolus quantity, to enable a therapy device to deliver the user-determined bolus quantity, to determine that the determined previously monitored variation in the analyte level exceeds a predetermined threshold, and in response to the determined previously monitored variation in the analyte level exceeding the predetermined threshold, temporarily disable the therapy device from delivering the user-determined bolus quantity; and
a user interface in signal communication with the processor to output a warning of an impending hypoglycemic condition based on the determined previously monitored variation in the analyte level based on the monitored activity level of the user, the user interface configured to output the warning by at least displaying a therapy information relating to the user-determined bolus quantity and a prompt to receive a user input to confirm that the user-determined bolus quantity should be delivered, the therapy information and the prompt to receive the user input being overlaid on a real-time depiction of the analyte level;
wherein the processor is configured to, in response to the user input, re-enable the therapy device to deliver the user-determined bolus quantity.

US Pat. No. 10,478,107

NON-INVASIVE PHYSIOLOGICAL SENSOR COVER

Masimo Corporation, Irvi...

1. A method of providing a sensor cover for a noninvasive optical physiological sensor, the method comprising:providing a sensor cover comprising:
a first cover portion attachable to the sensor and configured to block at least a portion of light from one or more emitters of the sensor from being received by a detector of the sensor when the sensor is active; and
a second cover portion that protrudes from the sensor to facilitate removal of the sensor cover; and
removably attaching the sensor cover to the sensor,
wherein the sensor comprises:
the one or more emitters configured to emit light; and
the detector configured to receive at least some of the light emitted by the one or more emitters after the light has passed through a tissue site.

US Pat. No. 10,478,106

PROBE, SYSTEM, AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES

1. A measuring probe for non-invasive in vivo measurement of blood analytes by Raman spectroscopy, the measuring probe comprising a housing having a skin engaging surface for engaging a subject's skin, the housing comprising:a first optical system comprising light guiding optics configured to direct source light, as a collimated beam, to the skin engaging surface and further configured to cause penetration of the subject 'skin with said collimated beam, for interacting of the collimated beam with the blood analytes, wherein angles between rays of light in the collimated beam are within a threshold value of 10 degrees; and
a second optical system configured to collect scattered Raman light, obtained from scattering of the collimated beam by the blood analytes, for use in measurement of the blood analytes;
wherein the first optical system is configured to direct the collimated beam at an oblique incidence angle with respect to a normal incidence angle of the skin engaging surface; and
wherein the second optical system is configured to spatially separate the scattered Raman light from a specular reflection of the collimated beam from the subject's skin.

US Pat. No. 10,478,105

EXTRACORPOREAL CIRCULATION MANAGEMENT DEVICE AND EXTRACORPOREAL CIRCULATION DEVICE HAVING IT

TERUMO KABUSHIKI KAISHA, ...

1. An extracorporeal circulation management device comprising:first controller means programmed for determining a plurality of first oxygenation-related parameter values of blood supplied from an output of an oxygenator unit that carries out gas exchange of blood to a target person with time-course information and for determining a plurality of second oxygenation-related parameter values of blood introduced from the target person into an input of the oxygenator unit with time-course information;
calculation means programmed for determining in-body passing time information defining a time period for blood supplied from the output of the oxygenator unit to the target person to be discharged from the target person according to a bloodstream volume of the target person and a flow rate of the supplied blood; and
second controller means programmed for selecting first oxygenation-related parameter values separated by the stored in-body passing time information and for selecting second oxygenation-related parameter values separated by the calculated in-body passing time information as comparison targets to evaluate oxygenation consumption of the target person;
wherein the calculation means is further programmed to correct the in-body passing time information according to locations on the target person where the blood is introduced from the oxygenator unit into the target person and where the blood is discharged from the target person.

US Pat. No. 10,478,103

APPARATUS, SYSTEMS, AND METHODS FOR DETERMINING AND DISPLAYING PRE-EVENT AND POST-EVENT ANALYTE CONCENTRATION LEVELS

Ascensia Diabetes Care Ho...

1. A hand-held device for identifying and displaying event readings, the hand-held device comprising:a processor;
a memory coupled to the processor;
software stored in the memory and executable by the processor; and
a display coupled to the processor and operable to present a graphical user interface (GUI), wherein the processor executing the software is operable to:
receive at the hand-held device from a measurement device a first analyte concentration reading and a second analyte concentration reading, both readings associated with a first event;
calculate a numerical delta between the first analyte concentration reading and the second analyte concentration reading for the first event with the hand-held device; and
display on the display via the GUI a time graph including a representation of the first event occurring and the numerical delta associated with the first event, wherein the numerical delta is displayed proximate to the representation of the occurrence of the first event to facilitate immediate visual evaluation of a relative magnitude of the numerical delta and an association with the first event, both indicating a significance of the first event.

US Pat. No. 10,478,102

NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS

MEDTRONIC MINIMED, INC., ...

1. A method of covering an introducer needle comprising:providing a sensor hub, a sensor, and an introducer, the introducer being configured to insert the sensor into a patient, the introducer comprising:
a housing detachably connectable to the sensor hub, wherein the sensor hub contains the sensor prior to connection to the housing, the housing including a needle cover, wherein the needle cover is an internal compartment of the housing;
a needle that is moveable with respect to the needle cover and is extendable out of, and retractable into, the housing;
a needle holder connected to the needle and contained within the housing; and
a spring having a top end in contact with the needle holder and a bottom end in contact with the housing,
wherein said needle holder and spring are configured such that, when the housing is connected to the sensor hub, said spring is in a compressed position and the needle extends out of the housing to insert the sensor into the patient, and such that disconnection of the housing from the sensor hub causes said spring to expand, thereby retracting the needle into the housing to be covered by said needle cover inside the housing, and the sensor remaining inserted in the patient;
wherein the housing includes a mating component to mate with the sensor hub and hold said spring in said compressed position when the housing is connected to the sensor hub; and
wherein the mating component includes a lock that locks the needle holder into a needle extended position when the housing is connected to the sensor hub, and when the mating component is not mated with the sensor hub the housing is completely detached from the sensor hub;
connecting the housing to the sensor hub so as to insert the sensor into the patient; and
disconnecting the housing from the sensor hub, whereby the needle cover covers the needle when the housing is detached from the sensor hub.

US Pat. No. 10,478,101

CONTINUOUS GLUCOSE MONITORING BASED ON REMOTE SENSING OF VARIATIONS OF PARAMETERS OF A SIC IMPLANTED ANTENNA

University of South Flori...

1. A passive sensing continuous glucose monitoring system for continuously monitoring a glucose level in a patient or subject, comprising:an external transmitting antenna that is configured to be positioned outside of a body of said patient or subject, said transmitting antenna transmitting a radiofrequency signal into said body of said patient or subject;
a passive internal antenna formed of silicon carbide and including an amorphous silicon carbide insulation, said internal antenna configured to be positioned subdermally in said patient or subject, said internal antenna receiving said radiofrequency signal from said transmitting antenna and configured to reflect said radiofrequency signal out of said body of said patient or subject, wherein a resonant frequency of said internal antenna varies as said blood glucose level in said patient or subject changes;
an external receiving antenna that is configured to be positioned outside of said body of said patient or subject, said receiving antenna receiving said reflected radiofrequency signal from said internal antenna,
wherein said external transmitting antenna and said external receiving antenna are disposed in proximity to each other, and said passive internal antenna is mounted directly towards said external transmitting antenna and said external receiving antenna;
one or more power sources for powering said external transmitting antenna and said external receiving antenna,
wherein said received radiofrequency signal is translated into a measure of said glucose level of said patient or subject;
a display for displaying said measure of said glucose level of said patient or subject.

US Pat. No. 10,478,099

SYSTEMS AND METHODS FOR DETERMINING AXIAL ORIENTATION AND LOCATION OF A USER'S WRIST

Apple Inc., Cupertino, C...

1. A strap for a wearable device, the strap comprising:an inner side and an outer side;
a plurality of strap holders configured to attach to a first edge and a second edge of a wearable device body; and
a plurality of capacitance sensors located on the inner side of the strap, the plurality of capacitance sensors configured to sense one or more changes in capacitance due to one or more forces of a user's wrist causing one or more changes in capacitance coupling, the plurality of capacitance sensors configured to generate one or more capacitance signals indicative of the one or more changes in capacitance coupling,
wherein the plurality of capacitance sensors is arranged as a grid of drive lines and sense lines.

US Pat. No. 10,478,098

INFORMATION PROCESSING SYSTEM

FUJI XEROX CO., LTD., To...

20. An information processing system comprising:a sheet that is usable in a use mode which is any one of an underlay mode and a cover mode;
a determination unit that determines that the sheet is in one of a state in which the sheet is used in the underlay mode, a state in which the sheet is used in the cover mode, and a state in which the sheet is not used, based on data detected by one or more sensors provided in the sheet; and
a unit that calculates a time during which a user is seated based on a length of time in which the sheet is determined to be used in the underlay mode or the cover mode by the determination unit.

US Pat. No. 10,478,095

SYSTEM AND METHOD FOR REAL-TIME PERSONNEL FATIGUE LEVEL MONITORING

Dharma P. Agrawal, Cinci...

1. A system for embedding in a shoe and monitoring fatigue level of a subject, wherein said shoe having a sole, comprising:a plurality of sensors disposed in the shoe sole;
a micro-controller communicatively connecting to said plurality of sensors and configured to receive readings of said plurality of sensors, and is further configured to validate the readings of a first sensor of the plurality of sensors with readings of a second sensor, wherein the first sensor of the plurality of sensors is a ball tilt sensor configured to detect orientation of the subject to generate first sensor data and the second sensor is an accelerometer configured to generate second sensor data used to reduce an error in the first sensor data; and
a wireless interface communicatively connecting to said micro-controller and configured to send the readings of said plurality of sensors wirelessly to a base station, wherein said base station determines the fatigue level of the subject based on at least a portion of the readings of said plurality of sensors transmitted by the wireless interface.

US Pat. No. 10,478,094

KETONE MEASUREMENT SYSTEM CAPABLE OF DETERMINING CASUAL COMPONENTS OF A KETONE MEASUREMENT

Invoy Holdings, LLC, Ali...

1. A system, comprising:a breath analysis device, the breath analysis device comprising a breath input port that receives a breath sample of a user and a ketone sensor that generates a breath ketone measurement representing a ketone level in the breath sample, the breath analysis device further comprising a wireless transceiver;
a data processing system comprising one or more processors and a wireless transceiver, the data processing system configured to communicate wirelessly with the breath analysis device and to receive from the breath analysis device a data value representing the breath ketone measurement, the data processing system comprising a user interface that prompts the user to supply, in association with breath sample, data regarding ingestion by the user of a confounding substance, including data regarding ingestion by the user of excess dietary fat;
wherein the data processing system is configured to generate, based on the data regarding ingestion by the user of a confounding substance, an estimate of a portion of the breath ketone measurement that is attributable to metabolism of stored fat, and is programmed to generate, and display in the user interface, a breakdown of the breath ketone measurement into at least a portion caused by metabolism of stored fat and a portion not caused by metabolism of stored fat, wherein the breakdown further indicates, for the portion not caused by metabolism of stored fat, how much is attributable to consumption of excess dietary fat.

US Pat. No. 10,478,091

METHOD AND DEVICE FOR DETECTING POSITION OF MICRO ROBOT USING ULTRA WIDE-BAND IMPULSE RADAR SIGNAL

Electronics and Telecommu...

1. A method of detecting a position of a micro robot, the method comprising:emitting an ultra wide-band impulse radar signal to a space in which a micro robot is;
driving the micro robot with electromagnetic field;
using a reflected signal of the ultra wide-band impulse radar signal to detect a natural oscillating resonance frequency signal generated when the micro robot is driven, to extract a micro robot signal;
analyzing the micro robot signal to calculate position information for the micro robot,
acquiring a real-time image data for a subject where the micro robot is inserted; and
performing position correction on the calculated position information based on pre-stored reference image and the real-time image data.

US Pat. No. 10,478,090

SPECTRAL BIN UN-ALIASING FOR REDUCED FIELD-OF-VIEW MAGNETIC RESONANCE IMAGING NEAR METAL IMPLANTS

Medical College of Wiscon...

1. A magnetic resonance imaging (MRI) system comprising:a MRI scanner, including a plurality of radio frequency (RF) receivers, for imaging objects of interest;
at least one processor; and
a memory, with computer code instructions stored thereon, the computer code instructions, when executed by the at least one processor, cause the at least one processor to:
cause the MRI scanner to perform a first scan, on an anatomy region including an implant, according to a first field of view to acquire first multi-spectral MRI data associated with a plurality of frequency bins;
compute, for each pair of a single RF receiver and a single frequency bin, a respective spectral sensitivity map using at least a portion of the first multi-spectral MRI data;
cause the MRI scanner to perform a second scan according to a second field of view to acquire second multi-spectral MRI data associated with the plurality of frequency bins, the second field of view smaller than the first field of view; and
reconstruct one or more MRI images according to the second field of view using the second multi-spectral MRI data and the spectral sensitivity maps.