1. An in vivo method of treating or preventing a viral infection in a mammal comprising administering a composition comprising:(a) a pharmaceutically acceptable grade of squalamine or a pharmaceutically acceptable salt or derivative thereof in an amount sufficient to produce an antiviral effect, and
(b) at least one pharmaceutically acceptable carrier,
wherein the viral infection is caused by a virus selected from the group consisting of Yellow Fever, Eastern Equine Encephalitis virus, Human Immunodeficiency virus (HIV), African Swine Fever Viruses, Arbovirus, Adenoviridae, Arenaviridae, Arterivirus, Astroviridae, Baculoviridae, Bimaviridae, Bimaviridae, Bunyaviridae, Caliciviridae, Caulimoviridae, Circoviridae, Coronaviridae, Cystoviridae, EBV, Deltaviridae, Filviridae, Filoviridae, Flaviviridae, Iridoviridae, Mononegavirus, Myoviridae, Papiloma virus, Papovaviridae, Paramyxoviridae, Prions, Parvoviridae, Phycodnaviridae, Poxviridae, Potyviridae, Reoviridae, Retroviridae, Rhabdoviridae, Tectiviridae, Togaviridae, pox, papilloma, corona, influenza, sendai virus (SeV), sindbis virus (SINV), vaccinia viruses, West Nile, Hanta, viruses which cause the common cold, and any combination thereof, and
wherein the composition is systemically administered intravenously, subcutaneously, intramuscularly, orally, or by inhalation.