US Pat. No. 10,596,378

METHOD FOR TREATMENT OF DEPRESSION USING SYNAPTIC PATHWAY TRAINING

1. A method of treating a neurologic condition by synaptic pathway training comprising the steps of:activating a synaptic pathway with a pharmacologic agent in an amount in the range of from about 0.5 to about 1 mg/kg; and
stimulating the activated synaptic pathway.

US Pat. No. 10,596,377

SEIZURE DETECTION, PREDICTION AND PREVENTION USING NEUROSTIMULATION TECHNOLOGY AND DEEP NEURAL NETWORK

International Business Ma...

1. A method for neuromodulation, the method comprising:monitoring brain activity of a patient using one or more electrodes attached to the patient;
predicting, using a first machine learning model, whether a patient will have a seizure based on the monitored brain activity of the patient;
responsive to the first machine learning model predicting that the patient will have a seizure, determining, using a second machine learning model, a neuromodulation signal pattern for preventing the predicted seizure;
using a neurostimulator to apply the determined neuromodulation signal pattern to the patient;
after applying the determined neuromodulation signal pattern to the patient, detecting whether the patient had the predicted seizure based on the monitored brain activity of the patient; and
adjusting at least the second machine learning model based on whether the patient had the predicted seizure.

US Pat. No. 10,596,376

STIMULATION OF THE VENTRAL PALLIDUM FOR THE TREATMENT OF EPILEPSY

ALBANY MEDICAL COLLEGE, ...

1. A method of treating a patient having seizures and that is at risk for sudden unexpected death in epilepsy (SUDEP), comprising the step of applying electrical stimulation to the ventral pallidum of the patient at a frequency of 50 Hertz for at least a first predetermined period of time that is sufficient to reduce epileptiform activity in the nucleus tractus solitarius (NTS) and prebotzinger complex (PBC) of the patent and avert cardiac disfunction associated with the patient that is at risk for SUDEP.

US Pat. No. 10,596,374

SINUS TREATMENT DEVICE WITH ENHANCED TIP

TIVIC HEALTH SYSTEMS INC....

1. A sinus treatment device, comprising:a housing configured to be held in a hand;
a return electrode operatively coupled to the housing;
a conductive tip;
sinus treatment circuitry positioned within the housing and configured to detect sinus treatment locations on a face of a user based on an impedance between the conductive tip and the return electrode and to pass a treatment current between the conductive tip and the return electrode via the sinus treatment location on the face of the user by applying a stimulation voltage between the conductive tip and the return electrode; and
a resilient member coupled to the conductive tip and configured to enable the conductive tip to resiliently depress toward the housing, wherein the resilient member is positioned within the housing.

US Pat. No. 10,596,372

TARGETED STEERABLE TRANSCRANIAL INTERVENTION TO ACCELERATE MEMORY CONSOLIDATION

HRL Laboratories, LLC, M...

1. A system for steerable transcranial intervention to accelerate memory consolidation, the system comprising:one or more processors and a memory, the memory being a non-transitory computer-readable medium having executable instructions encoded thereon, such that upon execution of the instructions, the one or more processors perform operations of:
generating a unique transcranial and steerable stimulation tag to associate with memory of a task or event;
activating at least a plurality of electrodes to apply the unique transcranial and steerable stimulation tag during an occurrence of the task or event; and
wherein activating the plurality of electrodes includes applying an electrical stimulation to a region of stimulation through the unique transcranial and steerable stimulation tag such that the region of stimulation is varied during application of unique transcranial and steerable stimulation tag.

US Pat. No. 10,596,369

LOW EQUIVALENT SERIES RESISTANCE RF FILTER FOR AN ACTIVE IMPLANTABLE MEDICAL DEVICE

Greatbatch Ltd., Clarenc...

1. A hermetically sealed filtered feedthrough assembly that is attachable to an opening of a housing of an active implantable medical device (AIMD), the filtered feedthrough assembly comprising:a) an electrically conductive ferrule comprising a ferrule opening, wherein the ferrule is configured to be attachable to an opening in a housing of an AIMD;
b) an insulator at least partially residing in the ferrule opening where a first gold braze hermetically seals the insulator to the ferrule, the insulator comprising an insulator outer surface extending to an insulator body fluid side and to an insulator device side, wherein, when the ferrule is attached to the housing of the AIMD, the insulator body fluid and device sides reside outside and inside the AIMD, respectively;
c) at least one insulator active via hole extending through the insulator to the insulator body fluid and device sides;
d) an electrically conductive active leadwire residing in the at least one insulator active via hole where a second gold braze hermetically seals the active leadwire to the insulator, the active leadwire extending from an active leadwire body fluid side portion to an active leadwire device side portion; and
e) a capacitor disposed adjacent to the insulator device side, the capacitor comprising:
i) a capacitor dielectric comprising a capacitor dielectric outer surface extending to a capacitor dielectric first side adjacent to the insulator device side and to a capacitor dielectric second side, wherein the capacitor dielectric supports at least one active electrode plate interleaved in a capacitive relationship with at least one ground electrode plate;
ii) a capacitor active metallization supported on the capacitor dielectric and being conductively connected to the at least one active electrode plate, wherein an active electrical connection conductively connects the active leadwire to the capacitor active metallization; and
iii) a capacitor ground metallization supported on the capacitor dielectric and being conductively connected to the at least one ground electrode plate, wherein a ground electrical connection conductively connects the capacitor ground metallization to the ferrule, and
iv) wherein the capacitor dielectric has a dielectric constant k that is greater than 0, but less than 1000, and
v) wherein the capacitor is the first filter capacitor conductively connected to the conductive leadwire device side portion at or adjacent to the insulator device side.

US Pat. No. 10,596,367

SYSTEMS AND METHODS FOR ESTABLISHING A NERVE BLOCK

SetPoint Medical Corporat...

1. A nerve cuff for establishing a nerve block on a nerve, the nerve cuff comprising:a cuff body having a channel extending within a length of the cuff body for passage of a nerve, the cuff body having an elongate opening slit extending the length of the cuff body configured to be opened to provide access to the channel, and configured to be closed around the channel and thereby enclose the cuff body around the nerve;
a nerve blocking device positioned within the channel and removable from the channel via the elongate opening slit, the nerve blocking device including a housing with a controller, a reservoir and a pump disposed therein, the controller configured to activate the pump to transfer a nerve blocking agent from the reservoir to the nerve within the channel.

US Pat. No. 10,596,366

ORAL MUSCLE TRAINING

SIGNIFIER MEDICAL TECHNOL...

1. A trans mucosal neuromuscular electrical stimulation device comprising a mouthpiece, the mouthpiece comprises a pair or arms joined together at one end and diverging from one another, at least one of the arms comprises a first member shaped to cooperate with or approximate or accommodate a dorsal tongue surface, and at least one of the said pair of arms comprises a second member, wherein the first member comprises a first electrode, and the second member comprises a second electrode, the mouthpiece further comprises electrical circuitry operatively connected to the first and second electrodes, wherein the device is configured to provide, in use, via the first electrode to the second electrode or via the second electrode to the first electrode, electrical stimulation from a first side to a second side of the mouthpiece, through the tongue to increase resting muscle tone and/or muscle tone during sleep.

US Pat. No. 10,596,365

GARMENT SYSTEM INCLUDING AT LEAST ONE SENSOR AND AT LEAST ONE ACTUATOR RESPONSIVE TO THE SENSOR AND RELATED METHODS

ELWHA LLC, Bellevue, WA ...

1. A garment system, comprising:at least one flexible compression garment configured to be worn on at least one body part of a subject, the at least one flexible compression garment defining an interior space configured to receive the at least one body part;
motion-conducive equipment;
one or more sensors disposed on or in the motion-conducive equipment, the one or more sensors configured to sense at least one characteristic associated with movement of the subject or at least one physiological characteristic of the subject, the one or more sensors further configured to output one or more sensing signals indicative of the at least one characteristic;
one or more actuators positioned relative to the at least one flexible compression garment and configured to selectively constrict or selectively dilate the at least one flexible compression garment; and
a control system operably coupled to the one or more actuators and further operably coupled to the one or more sensors to receive the one or more sensing signals therefrom, the control system including control electrical circuitry configured to direct the one or more actuators to selectively constrict or selectively dilate the at least one flexible compression garment responsive to the one or more sensing signals from the one or more sensors;
wherein the control system includes a user interface through which the control system can be programmed with at least one operational program that controls an amount of selective constriction or selective dilation applied by the one or more actuators and the user interface is remote from at least one of the subject or the motion-conducive equipment.

US Pat. No. 10,596,363

MEDICAL TREATMENT TOOL

TERUMO KABUSHIKI KAISHA, ...

1. A medical treatment tool comprising:a bendable tube configured to be inserted into a body of a patient;
an operating body disposed in the bendable tube and configured to cause bending of the bendable tube, the operating body including:
a plurality of divided members that are divided from each other along axially extending edges of adjacent divided members, portions of the divided members forming a tubular structure, and
an annular connecting portion, an outer surface of the annular connecting portion being continuous with outer surfaces of the divided members; and
a cylindrical member located inside the operating body,
wherein each divided member comprises a cutout portion formed between the tubular structure and the annular connecting portion, and
wherein the cylindrical member is in contact with inner surfaces of the divided members.

US Pat. No. 10,596,362

PERCUTANEOUS DRUG DELIVERY APPARATUS

RENISHAW (IRELAND) LIMITE...

1. An implantable percutaneous fluid delivery device comprising:a subcutaneous base portion comprising one or more ports configured to supply fluid to one or more implanted catheter devices; and
a percutaneous portion comprising an extracorporeal surface, the one or more ports of the subcutaneous base portion configured to be accessible from the extracorporeal surface of the percutaneous portion, and at least part of the percutaneous portion comprises a at least one of a peripheral porous surface and a peripheral rough surface configured to encourage tissue ingrowth,
wherein the subcutaneous base portion is configured to be at least partially insertable into a complementary recess formed in a bone, the subcutaneous base portion comprising at least one bone anchor configured to grip an internal surface of the complementary recess in order to directly secure the subcutaneous base portion to the bone.

US Pat. No. 10,596,358

DEVICES AND METHODS FOR INTRALUMINAL RETENTION AND DRUG DELIVERY

PALO ALTO RESEARCH CENTER...

1. A device for drug delivery comprising:a housing configured for intraluminal deployment into a lumen of a human or animal subject;
at least one reservoir contained within the housing, the at least one reservoir having an actuation end and a release end and containing at least one drug formulation;
a plug within the at least one reservoir and moveable from the actuation end toward the release end;
an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir;
at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject; and
a retention member release mechanism configured to be slideable with respect to the housing in a direction from the release end toward the actuation end to transform the retention member from the retention position to the deployment position.

US Pat. No. 10,596,357

ENDOVASCULAR CEREBROSPINAL FLUID SHUNT

Tufts Medical Center, Inc...

1. A method for draining cerebrospinal fluid from a patient's subarachnoid space into the venous system, the method comprising:providing a shunt having opposed first and second ends and a one-way valve, wherein the first and second ends are in fluid communication to enable the cerebrospinal fluid to be drained from the subarachnoid space through the second end, the first end and the valve into the venous system;
endovascularly delivering the shunt to a dural venous sinus;
stabilizing the shunt against an inner wall of the dural venous sinus at a desired location proximal to the subarachnoid space;
implanting a portion of the shunt through the venous sinus wall of the patient; and
draining cerebrospinal fluid from the patient's subarachnoid space into the patient's venous system.

US Pat. No. 10,596,356

METHODS FOR PLACING A STENT-GRAFT TO COVER COLLATERAL VESSELS IN LOWER EXTREMITY VASCULATURE

LimFlow GmbH, Dresden (D...

1. A method of modifying a vessel including covering collateral vessels of the vessel, the method comprising:forming a fistula between a first vessel and the vessel, wherein the first vessel is an artery and the vessel is a vein, wherein forming the fistula comprises:
inserting a first catheter into the first vessel, the first catheter comprising a needle being configured to radially extend from the first catheter;
inserting a second catheter into the vessel, the second catheter comprising an expandable device; and
extending the needle from the first catheter, wherein extending the needle comprises:
exiting the first vessel,
traversing interstitial tissue between the first vessel and the vessel,
entering the vessel, and
puncturing the expandable device to confirm advancement of the needle into the vessel;
advancing a guidewire from the first vessel, through the needle, and into the vessel;
deploying a prosthesis at least partially in the fistula, wherein deploying the prosthesis comprises:
tracking the prosthesis over the guidewire, and
expanding the prosthesis with a balloon,
wherein after deploying the prosthesis, blood is diverted from the first vessel to the vessel through the prosthesis; and
making the valves in the vessel incompetent, wherein making the valves in the vessel incompetent comprises positioning a stent-graft in the vessel,
wherein positioning the stent-graft in the vessel comprises covering the collateral vessels of the vessel,
wherein the stent-graft is separate from the prosthesis, and
wherein a proximal segment of the stent-graft longitudinally overlaps a distal segment of the prosthesis.

US Pat. No. 10,596,351

SELF-SEALING CATHETER VALVE

TRAINCO AB, Stockholm (S...

1. A peripheral catheter assembly comprising:a catheter hub or other tubular passageway that has an internal surface; and
a self-sealing peripheral catheter valve including:
a flexible tubular part having a distal opening and an opposite proximal opening, and
a proximal valve part that has a curved self-sealing flexible diaphragm disposed inside the flexible tubular part and has a base perimeter united with a circumferential wall of the flexible tubular part at an axial distance from the proximal opening of said catheter valve, and an annular flange which defines or includes the base perimeter and which has an external surface that includes an exterior diameter that is larger than the exterior diameter of the flexible tubular part,
wherein the curved self-sealing flexible diaphragm has a concave surface facing towards the proximal opening and a convex surface facing towards the distal opening, and
wherein the curved self-sealing flexible diaphragm has a traverse slit,
wherein the convex surface of the curved self-sealing flexible diaphragm has an upright rib extending crosswise and perpendicular to the traverse slit towards the interior surface of the circumferential wall of the flexible tubular part, and
wherein the catheter valve is present in the catheter hub or passageway with the external surface of the annular flange of the tubular part in contact with the internal surface of the catheter hub or passageway, so that the catheter valve provides a fluid tight seal in the catheter hub or passageway, wherein the exterior surface of the circumferential wall of the flexible tubular part has at least two protuberances, positioned diametrically opposite each other on a line taken through the upright diametrical ribs of the diaphragm.

US Pat. No. 10,596,350

CATHETER SECUREMENT DEVICE WITH DUAL RETENTION STRAPS

KT KYUIK, LLC, Satellite...

1. A catheter securement device comprising a main body, a mounting body affixed to said main body, and retention strap members in an unfolded configuration extending from said mounting body;said main body having an upper side and an adhesive underside, said main body defining a transverse axis and a longitudinal axis perpendicular to said transverse axis, said transverse axis being disposed between said retention strap members;
said retention strap members each having a free end;
said mounting body being affixed onto said upper side of said main body; said mounting body and said retention strap members having adhesive upper surfaces;
whereby the junction of each of said retention strap members with said mounting body defines a fold line, such that said fold line is non-parallel and non-perpendicular to both said transverse axis and said longitudinal axis and wherein the combination of said fold lines define an angle facing away from said free ends of said retention strap members in the unfolded configuration of less than 180 degrees;
whereby said retention straps are structured such that with a catheter positioned on said mounting body along said transverse axis and said retention strap members folded toward said mounting body along said fold lines, said retention strap members are sized and angled to extend across said transverse axis, across the catheter, across each other, and beyond said main body on opposite sides of the catheter.

US Pat. No. 10,596,348

CONDUCTIVE TIP CATHETER

TELEFLEX MEDICAL INCORPOR...

22. A conductive tip catheter, comprising:a flexible tubular member comprising a proximal end and a distal end, the flexible tubular member defining a lumen extending between the proximal end and the distal end;
an electrically conductive metallic coil at least partially located within the lumen of the flexible tubular member, the metallic coil comprising:
a first region located at a distal end of the metallic coil and having a first pitch;
a second region proximal to the first region and having a second pitch that is greater than the first pitch; and
a third region proximal to the second region and having a third pitch that is less than the second pitch;
a conductive tip made from carbon-filled polyurethane and welded over and around the first region of the metallic coil through radio frequency welding, the conductive tip defining a tip lumen in fluid communication with the lumen; and
a safety ribbon located within the lumen of the flexible tubular member, the safety ribbon coupled to the electrically conductive metallic coil at a distal region of the electrically conductive metallic coil and a proximal region of the electrically conductive metallic coil,
wherein the electrically conductive metallic coil directly connects to the flexible tubular member at each point of contact between the electrically conductive metallic coil and the flexible tubular member.

US Pat. No. 10,596,346

TRIAXIAL FIBER OPTIC FORCE SENSING CATHETER

1. A catheter for exploration or treatment of a vessel, organ or other tissue, comprising:a flexible elongated body having a proximal end and a distal extremity; and
a fiber optic force sensing assembly disposed within the flexible elongated body proximate the distal extremity, the fiber optic force sensing assembly including:
a structural member having an outer surface and defining a longitudinal axis, the structural member including a plurality of segments that are adjacent each other to define a plurality of gaps, each of the plurality of gaps being located between adjacent ones of the plurality of segments;
a plurality of flexures dispersed between the plurality of segments so that the adjacent ones of the plurality of segments are bridged by one of the plurality of flexures, each of the flexures defining a portion of the outer surface of the structural member; and
a fiber optic operatively coupled with the structural member.

US Pat. No. 10,596,345

SYSTEMS AND METHODS FOR HUMIDITY CONTROL

VAPOTHERM, INC., Exeter,...

1. A method for humidifying a breathing gas using a vapor transfer unit, the method comprising the steps of:delivering gas to a vapor transfer unit having a vapor transfer device and a bypass gas passage having a constriction positioned therein, the constriction comprising a ring-shaped protrusion that narrows a portion of the bypass gas passage, wherein the gas is delivered at a gas flow rate;
passing a fraction of the gas through the constriction in the bypass gas passage; and
automatically altering the fraction of the gas passed through the bypass gas passage inversely with a change in the gas flow rate.

US Pat. No. 10,596,343

OXYGEN SENSOR ASSEMBLY FOR MEDICAL VENTILATOR

COVIDIEN LP, Mansfield, ...

1. A medical ventilator comprising:a manifold comprising a first air flow path to a patient circuit;
a port in the manifold, the port comprising a second air flow path through an opening in the port, wherein the first and second air flow paths are in fluid communication with each other, and wherein the port is configured to mate with a removable oxygen sensor assembly, comprising:
a sensor adapter including a body that forms a cavity; and
an oxygen sensor removably retained by the cavity of the sensor adapter; and
a valve biased toward a closed position in which the valve closes the opening, wherein the valve is movable, by insertion of such oxygen sensor assembly, into an open position in which the second air flow path through the opening is exposed.

US Pat. No. 10,596,342

BREATHING MASK FOR FEEDING A BREATHING GAS TO A MASK USER AND DISCHARGE DEVICE FOR DISCHARGING BREATHING GAS

1. A breathing mask arrangement for delivering breathable gas to a patient for treatment of sleep disordered breathing, the breathing mask arrangement comprising:a frame including a main body and a forehead support movably coupled to the main body, the forehead support including a pair of upper head band coupling structures and the main body including a pair of lower head band coupling structures;
a mask configured to releasably couple with the frame, the mask including a body portion and a sealing portion,
the body portion forming a mask interior breathing chamber pressurizable to a therapeutic pressure, and the body portion including an inlet opening structured to receive a flow of gas at the therapeutic pressure for breathing by the patient,
the body portion includes an inside surface exposed to said therapeutic pressure in use and an outside surface exposed to ambient pressure, and the main body of the frame includes a side wall arranged along the outside surface of the body portion so that the side wall is outside the mask interior breathing chamber, and
the sealing portion is constructed and arranged to form a seal with at least nasal bridge and cheek regions of a patient's face, the sealing portion including a hole therein adapted to receive a patient's nose such that the flow of gas at the therapeutic pressure is delivered to the patient's nose;
an adjustment arrangement to allow selective adjustment of the forehead support relative to the main body, the adjustment arrangement including a fixing mechanism to positively lock the forehead support relative to the main body in one of a plurality of predetermined or fixed positions;
a gas hose connector structured to connect to a breathing gas hose to deliver the flow of gas at the therapeutic pressure to the mask interior breathing chamber of the mask, wherein the gas hose connector is configured to communicate with the mask through the inlet opening of the body portion; and
a head band assembly to maintain the breathing mask arrangement in position on a patient's head, the head band assembly including an upper head band arrangement adapted to connect to the pair of upper head band coupling structures of the frame and a lower head band arrangement adapted to connect to the pair of lower head band coupling structures of the frame.

US Pat. No. 10,596,341

MODULARIZED RESPIRATORY TREATMENT APPARATUS

ResMed Pty Ltd, (AU)

1. A system for respiratory pressure treatment, the system comprising:a respiratory pressure treatment module having a flow generator, the respiratory pressure treatment module including a controller, with at least one processor, the controller configured to control the flow generator to generate a pressure treatment to a patient interface according to first and second pressure therapy regimes,
wherein the controller is configured to enable the first pressure therapy regime and disable the second pressure therapy regime in an absence of a detection by the controller of an alarms module, and enable the second pressure therapy regime based on a detection by the controller of a presence of the alarms module, and
wherein the alarms module includes:
a breathable gas flow channel including an inlet coupling and outlet coupling, the inlet coupling adapted to couple with a breathable gas flow output of the respiratory pressure treatment module;
an alarm controller including at least one processor, the processor configured for activating an alarm associated with operation of the respiratory pressure treatment module;
an electrical coupler, the coupler adapted for electrical communication between the alarm controller and the controller of the respiratory pressure treatment module; and
a modularized housing configured to retain the channel and the alarm controller, the modularized housing adapted for coupling with a housing of the respiratory pressure treatment module.

US Pat. No. 10,596,339

INTUBATION DEVICES AND METHODS OF USE

1. An intubation device comprising: a laryngeal mask airway (LMA) component comprising a mask portion having an internal opening, and an elongated tube mounted to the mask portion, the elongated tube having an internal passageway in fluid communication with the internal opening of the mask portion; a movable endotracheal tube (ETT) component comprising an elongated tube positioned and movable within the elongated tube of the LMA component; and a manipulation rod mounted for translation through a passage in the LMA component, the manipulation rod extending longitudinally substantially parallel to a longitudinal axis of the LMA component, the manipulation rod having a first end operatively mounted to the ETT component and a second end, opposite the first end, positioned outside the LMA component to allow an operator to manipulate the second end of the manipulation rod to translate the ETT component within and along the LMA component.

US Pat. No. 10,596,338

TRACHEAL TUBE AND SUCTION DEVICE

NEVAP, INC., San Jose, C...

1. A tracheal tube system comprising:a first tube that is flexible and hollow and having a first open end and a second open end;
an inflatable balloon affixed to, and circumferentially surrounding an exterior portion of the first tube, the inflatable balloon being positioned between the first open end and the second open end of the first tube; and
a second tube, the second tube being hollow and having a multiplicity of holes along a sidewall of the second tube, the second tube being substantially perpendicular to the first tube, positioned above the inflatable balloon, and surrounding a portion of the first tube, wherein the second tube is configured to be coupled to a suction device that creates a negative pressure in the second tube and the second tube is positioned such that when the tracheal tube system is inserted into a trachea, the inflatable balloon is inflated, and negative pressure is applied to the second tube by the suction device, the second tube is positioned against a portion of a tracheal wall.

US Pat. No. 10,596,337

ADJUSTABLE TRACHEOSTOMA VALVE

1. A tracheostoma valve adapted to control the flow of air through a tracheostoma comprising:a first body including a passageway,
a second body movably coupled to the first body, the second body including a rim surface surrounding a bore that is aligned with the passageway of the first body,
an air permeable elastic membrane positioned in the passageway of the first body, and
a disk having a first surface that is sized to cover the bore of the second body, the disk being attached to the air permeable elastic membrane,
wherein the second body is movable relative to the first body to advance the bore toward and away from the passageway of the first body, and
wherein the air permeable elastic membrane is deflectable between a first position in which the disk is spaced apart from the bore of the second body to permit the passage of air through the bore and the first surface of the disk extends parallel to the rim surface of the second body and a second position in which the first surface of the disk engages the rim surface to cover the bore and prevent the passage of air through the bore.

US Pat. No. 10,596,332

DEVICE FOR ADJUSTING NEEDLE INSERTION DEPTH

SHL MEDICAL AG, Zug (CH)...

1. A penetration depth adjusting mechanism for a medicament delivery device, which extends a longitudinal axis comprising:a medicament delivery device housing having a proximal end and a distal end;
a medicament container arranged entirely inside of the medicament delivery device housing, wherein the medicament container is provided with a medicament delivery member;
a medicament delivery member cover coaxially arranged and movable in relation to the medicament delivery device housing; the penetration depth adjusting mechanism comprising:
a delivery member protruding adjuster operably connected to the medicament delivery member cover of the medicament delivery device and further comprises a signal generating mechanism arranged between the delivery member protruding adjuster and the medicament delivery member cover such that when the delivery member protruding adjuster is moved in relation to the medicament delivery member cover an audible and/or tactile and/or visual signal is generated,
wherein the medicament delivery member cover together with the delivery member protruding adjuster are movable in relation to the medicament delivery device housing from a first position in which the medicament delivery member is surrounded by the medicament delivery member cover or by both the medicament delivery member cover and the delivery member protruding adjuster, to a second position in which the medicament delivery member is enabled to protrude a depth measured from a proximal end of the delivery member protruding adjuster,
wherein the signal generating mechanism further comprises first signal elements arranged on the medicament delivery member cover of the medicament delivery device and second signal elements arranged on the delivery member protruding adjuster such that the first and second signal elements are able to interact with each other when displacement of the delivery member protruding adjuster occurs in relation to the medicament delivery member cover to thereby providing the audible and/or the tactile and/or the visual signal, and the first signal elements comprise at least one flexing element flexible in a direction generally perpendicular to a longitudinal axis of the penetration depth adjusting mechanism, and
wherein the first signal elements further comprise at least one protrusion and the second signal elements comprise a plurality of recesses, wherein the plurality of recesses correspond to a plurality of medicament delivery member protruding depth setups, wherein, when the at least one protrusion is moved in position with one of the plurality of recesses, the at least one flexing element will cause a sudden movement of the at least one protrusion into the one of the plurality of recesses, causing an impact, thereby providing the audible and/or the tactile and/or the visual signal indicating that one of the medicament protruding depth setup of the plurality of medicament delivery member protruding depth setups has been set.

US Pat. No. 10,596,331

PHARMACEUTICAL INJECTING DEVICE, DISPLAY CONTROL METHOD FOR PHARMACEUTICAL INJECTING DEVICE, AND INJECTION SITE DISPLAY DEVICE

PHC HOLDINGS CORPORATION,...

1. A pharmaceutical injecting device, comprising:a main body case having a pharmaceutical syringe installation component in which a pharmaceutical syringe is installed;
a piston that is provided movably with respect to the pharmaceutical syringe installed in the pharmaceutical syringe installation component;
a drive mechanism that drives the piston;
a display component that displays injection sites at which a pharmaceutical in the pharmaceutical syringe is injected; and
a display controller that causes the display component to display a plurality of the injection sites and to display, at two or more injection sites, selectable displays, respectively, indicating that the two or more injection sites are suitable for injection,
wherein, after injection, the display controller changes the selectable displays of one selected injection site of the two or more injection sites to an already-selected display indicating unsuitability for injection, and
wherein the display controller displays an article on the already-selected display at the one selected injection site of the two or more injection sites and displays an indication of a growth state of the article displayed at the one selected injection site of the two or more injection sites as an indicator as to when the one selected injection site of the two or more injection sites will again become selectable.

US Pat. No. 10,596,330

RESORBABLE, DRUG-ELUTING SUBMUCOSAL TURBINATE IMPLANT DEVICE AND METHOD

MEDTRONIC XOMED, INC., J...

1. A surgical device comprising:(a) a proximal grip portion configured to be grasped outside a patient;
(b) a distal hollow sharp needle portion configured to be manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue in the patient;
(c) one or more biodegradable, drug-eluting solid implants disposed within the hollow needle portion, the implants having a length along the hollow needle portion, and one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along the length; and
(d) an actuator disposed within the device and configured to deliver one or more of the implants from the hollow needle portion into the mucosal turbinate tissue and submucosally bury at least one of the implant withdrawal-discouraging, mucosal tissue-engaging surface features therein.

US Pat. No. 10,596,329

TORSION SPRING DRIVEN INJECTION DEVICE

1. A torsion spring driven injection device for delivering set doses of a liquid drug, comprising:a housing storing a cartridge containing a liquid drug,
a needle cannula in liquid communication with the interior of the cartridge and having a distal tip shielded by a telescopically movable needle shield, wherein the needle shield is axially movable from a first position in which the needle shield is extended to cover the distal tip of the needle cannula to a second position in which the needle shield is retracted to expose the distal tip of the needle cannula,
a piston rod having a threaded outer surface and a noncircular cross-section, for driving the liquid drug out from the cartridge through the needle cannula,
a rotatable dose setting member by which a user can set the size of a dose to be injected,
a torsion spring which is strainable in response to the user rotating the dose setting member and releasable to drive the piston rod, and
a user operable injection button, activation of which releases the torsion spring,
a rotatable drive member mating with the noncircular cross-section of the piston rod or having an inner thread mating with the outer thread of the piston rod, and
a nut member releasably coupled to the housing and having an inner thread mating with the outer thread of the piston rod or having a cross-section mating with the noncircular cross-section of the piston rod, such that the piston rod is moved axially in the housing upon rotation of the drive member relative to the housing, whereinthe needle shield is configured to lock the nut member to the housing upon telescopic movement of the needle shield from the first position to the second position.

US Pat. No. 10,596,328

SPRING-DRIVEN DRUG DELIVERY DEVICE

1. A drug delivery device, comprising:a housing,
a threaded piston rod defining an axial direction and having a proximal end and a distal end,
a rotatable drive tube,
a drive nut in threaded engagement with the piston rod and being rotationally locked but axially moveable relative to the drive tube,
a drive member being rotationally locked but axially moveable relative to the piston rod,
a support member arranged rotationally free on the piston rod and arranged to allow the drive tube to move axially, the support member being arranged axially stationary relative to the housing and arranged to allow the drive tube to move axially,
a compression drive spring arranged between the piston rod and the drive tube, the compression drive spring being arranged axially between the drive nut and the support member, and
dose setting structure allowing a user to set a dose amount of drug to be expelled, the compression drive spring being strained corresponding to the dose being set,
wherein the drive tube can be moved distally from a dose setting position to a drive position in which the drive tube non-rotationally engages the drive member and is allowed to rotate therewith.

US Pat. No. 10,596,325

PEN-TYPE DRUG INJECTION DEVICE WITH IRIS STYLE QUICK COUPLING FOR PISTON ROD RESETTING

Sanofi-Aventis Deutschlan...

1. A drug delivery device comprising:a housing having a longitudinal axis;
a piston rod;
a guide member for guiding the piston rod in a drug dispense operation; and
a cartridge holder for receiving a cartridge,
wherein the cartridge holder is detachable from the housing,
wherein the guide member comprises a hole with a variable diameter,
wherein the guide member comprises a plurality of segments,
wherein the segments are configured to pivot when the cartridge holder is being detached or attached to the housing, and
wherein the drug delivery device is configured such that the hole increases in diameter when the cartridge holder is being detached from the housing.

US Pat. No. 10,596,322

PUMP

Oxford Nanopore Technolog...

1. A pump comprising:a barrel for holding fluid; and
a piston for drawing fluid into the barrel and driving fluid out of the barrel, wherein the piston comprises a plunger configured to move within the barrel and a sheath configured to move around an outer surface of the barrel;
wherein an inner surface of the sheath and the outer surface of the barrel have complementary screw threads so that, in use, rotating the piston causes the piston to travel along the barrel;
wherein the piston has a piston head having a barrier portion;
wherein the barrier portion has a barrier surface configured to face a fluid being displaced within the barrel;
wherein a peripheral portion of the barrier portion is formed into a lip;
wherein the lip extends and projects at least partially around a resilient member;
wherein the plunger is hollow;
wherein the piston comprises an engagement section for engaging with a driving member and enabling the driving member to turn the piston; and
wherein the engagement section comprises an opening into the hollow plunger.

US Pat. No. 10,596,321

ASPIRATION AND INJECTION DEVICE

Allergan, Inc., Irvine, ...

1. A syringe comprising:a barrel having an inner lumen and a flange extending radially from a proximal end portion of the barrel for facilitating handling of the syringe during operation; and
a plunger having a plunger rod and a plunger head, the plunger rod having a distal end portion at least partially disposed within the inner lumen of the barrel and a proximal end portion coupled to the plunger head, the plunger head comprising proximal and distal-facing surfaces and a plurality of engagement structures extending distally from the distal-facing surface to facilitate gripping with a user's thumb during operation of the syringe.

US Pat. No. 10,596,315

SYSTEMS AND METHODS FOR DELIVERING A FLUID TO A PATIENT WITH REDUCED CONTAMINATION

Magnolia Medical Technolo...

1. A method, comprising:establishing fluid communication between a patient and a first channel of a fluid transfer device, the fluid transfer device including a seal, the seal being in a first state when establishing fluid communication;
receiving a first volume of fluid from the patient into the fluid transfer device via the first channel and into a second channel that extends from the first channel, the second channel including a valve seat and a valve, the valve in contact with the valve seat such that the valve forms a substantially fluid tight seal with a wall defining a portion of the second channel, the valve being in an open state during the receiving;
sequestering the first volume of fluid when the seal is in a second state and the valve is in a closed state;
after the first volume of fluid is sequestered, receiving a second volume of fluid into the fluid transfer device; and
providing, via the first channel, the second volume of fluid.

US Pat. No. 10,596,310

PORTABLE DIALYSIS MACHINE

Fresenius Medical Care Ho...

1. A dialysis machine comprising:a molded plastic substrate defining a first flow path which is fluidically isolated from a second flow path, wherein the molded plastic substrate is bonded to a plurality of tubing and wherein the plurality of tubing is bonded to a dialyzer;
a controller unit wherein the controller unit comprises:
a door having an interior face;
a housing with a panel wherein the housing and panel define a recessed region configured to receive the interior face of the door; and
a component receiver fixedly attached to the panel and configured to receive the molded plastic substrate; and
a transceiver configured to communicate data through a network, wherein the data comprises an identity of one or more disposable components installed in the dialysis machine; and
a reservoir unit in fluid communication with the controller unit, wherein the reservoir unit further comprises a member connected to an exterior of the reservoir unit and wherein the member is configured to physically receive the dialyzer.

US Pat. No. 10,596,309

HEMODIALYSIS SYSTEM

NextKidney SA, Lausanne ...

23. A method for purifying blood with a system including a dialysate circuit forming a loop circuit having a mixing bag, a dialyzer, and a sorbent device, a pumping device positioned in the loop circuit, and a supply bag including a supply solution, the method comprising the following steps:first actuating the pumping device to move a dialysate solution through the dialysate circuit such that the dialysate solution flows through the dialyzer to perform a dialysis treatment, then through the sorbent device to remove some solute included in the dialysate solution, and then to the mixing bag; and
second actuating the pumping device to move a supply solution from the supply bag to the dialysate circuit by a supply line into the dialysate circuit to reach the mixing bag, wherein the pumping device is the only means for pumping supply solution from the supply bag.

US Pat. No. 10,596,305

SUCTION CANISTER AND CORRESPONDING SYSTEMS AND METHODS

Medline Industries, Inc.,...

1. A canister system, comprising:a canister lid comprising an annular perimeter interrupted by a suction conduit defined by a suction duct separating a first lobe and a second lobe, the first lobe disposed interior of the annular perimeter, the second lobe disposed exterior to the annular perimeter, and the suction duct traversing the annular perimeter; and
a canister comprising a valve coupled to a mechanical support extending distally from a canister sidewall, the valve defining a duct from the second lobe of the canister lid when the canister lid is coupled to the canister;
wherein the canister lid defines a top side and an canister engaging side, the first lobe is disposed above a first aperture, the second lobe is disposed above a second aperture, and each of the first lobe and the second lobe are disposed on the canister engaging side of the canister lid.

US Pat. No. 10,596,302

CATHETER TUBING WITH TAILORED MODULUS RESPONSE

Becton, Dickinson and Com...

1. A catheter tubing comprising:an elongate body comprising a base thermoplastic polyurethane; and
a compounded thermoplastic polyurethane co-extruded with the base thermoplastic polyurethane to provide a section of catheter tubing discrete from the elongate body, the compounded thermoplastic polyurethane comprising a thermoplastic polyurethane and a radiopaque material;
wherein the catheter tubing comprises a first elastic modulus under first conditions prior to entry into a patient;
wherein when exposed to second conditions comprising two or more in vivo stimuli for a time, the catheter tubing comprises a second elastic modulus that is not more than fifty percent of the first elastic modulus; and
wherein the first elastic modulus is a minimum of 1300 MPa.

US Pat. No. 10,596,301

DEVICE INCLUDING BIOLOGICAL AGENTS FOR IN VITRO INDUCTION OF BIOMINERALIZATION

THE GOVERNING COUNCIL OF ...

1. A device for in vitro induction of biomineralization, comprising:a) a physiologically acceptable porous scaffold;
b) said porous scaffold being impregnated with a first layer of collagen gel;
c) a second collagen layer located on top of the first layer, said second layer including a mixture of collagen and Amelotin protein (AMTN), the Amelotin protein being present in the second collagen layer is an amount from about 5 to about 25% % by wt. in collagen solution; and
d) wherein in use said device is configured to be applied with said second layer with the mixture of collagen gel containing Amelotin protein in physical contact with a mineralized tissue surface, the device being characterized in that a presence of Amelotin protein in the second layer triggers the formation of hydroxyapatite mineral deposits that intimately connect the second layer with the mineralized tissue surface and thus provide physical attachment.

US Pat. No. 10,596,298

MALLEABLE DEMINERALIZED BONE COMPOSITION AND METHOD OF MANUFACTURE

Vivex Biologics Group, In...

1. A malleable demineralized bone composition consisting of cortical bone wherein a first portion of cortical bone is made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried and a second portion of cortical bone is shaved into shavings, the shavings being strips subjected to freeze-drying, the freeze-dried shavings being ground and demineralized to a particle size up to 125 microns and then freeze-dried a second time; and wherein a volume of the freeze-dried particles of the second portion placed in a solution of sterile water to create a mixture, the water volume being twice the volume of freeze-dried particles of the second portion, the mixture consisting of only demineralized cortical bone particles up to 125 microns and sterile water is autoclaved over 1.25 hours including conditioning of 15 minutes, exposure of 30 minutes and drying of 30 minutes, the exposure being under heat of 121.1 degrees C. at a pressure of 30.15 psi to liquify the bone particles to form a gelatin, the gelatin being cooled not to exceed 40° C. when the first portion is mixed with the liquid gelatin and thereafter cooled to form a malleable putty or paste, wherein the ratio of gelatin to particles from the first portion is 80:20 by volume and wherein the ground particles of the first portion are sieved to a first size range of 125 to 300 microns, a second size range 300 to 500 microns and a third range 500 to 850 microns and wherein the first size through second size and third size have a ratio of 40:40:20 by weight, respectively.

US Pat. No. 10,596,294

AIR CLEANER

SEOUL VIOSYS CO., LTD., ...

1. An air cleaner comprising:an outer housing formed with a suction port and a discharge port;
an inner housing disposed inside the outer housing and separated from the outer housing by a substantially cylindrical gap between an outer surface of the inner housing and an inner surface of the outer housing, wherein the inner housing is configured to receive air that passes through the substantially cylindrical gap from the suction port of the outer housing;
a fan disposed in the inner housing and inducing a discharge of air towards the discharge port;
a photocatalytic filter disposed in the inner housing in an air discharge direction from the fan or in an opposite direction to the air discharge direction;
a UV light source disposed before the photocatalytic filter in a direction of air flow entering from the suction port and passing through the fan and emitting UV light towards the photocatalytic filter; and
a collection filter disposed in the inner housing and arranged at a position before the fan, the photocatalytic filter and the UV light source in the direction of the air flow.

US Pat. No. 10,596,292

COMPACT AROMATIC DIFFUSER AND METHOD OF USE

1. A compact diffuser configured for portability and for distributing therapeutic essential oil aroma directly to an individual user, the compact diffuser comprising,a body portion, the body portion defining a diffuser cavity and including,
a battery;
a distribution fan powered by the battery, wherein the distribution fan is disposed within the diffuser cavity and proximate a plurality of holes formed in a sidewall of the body portion, wherein the distribution fan is configured to generate an airflow by drawing air through the plurality of holes and into the diffuser cavity during operation;
a programmable computer board disposed within the diffuser cavity and operably connected to the distribution fan;
an exhaust opening; and
at least one felt wicking element associated with the diffuser cavity such that the airflow generated by the distribution fan is directed along the at least one felt wicking element and out of the diffuser cavity; and
an adaptor fitting, wherein the adaptor fitting is configured to engage the exhaust opening of the compact diffuser and to couple the compact diffuser with an intake opening of a breathing mask.

US Pat. No. 10,596,291

EFFECTIVE ANTI-BACTERIA AND ANTI-VIRAL AIR TREATMENT DEVICE

KONINKLIJKE PHILIPS N.V.,...

18. A method for deactivating one or more of bacteria and viruses from air in a closed air space, the method comprising:providing an air treatment device into said closed air space, wherein said air treatment device includes a device chamber with an inlet opening and an outlet opening, and a deactivating material unit situated within the device chamber configured to host the deactivating material, the deactivating material unit comprising an opening in direct fluid contact with the device chamber,
arranging a deactivating material into a deactivating material enclosure partially enclosed by the device chamber of the air treatment device, and
activating a gas flow generation unit of the air treatment device to control the emission of said deactivating material into said closed air space with an emission rate of at maximum 250 mg/h from a release area, wherein said activation comprises introducing external air into the device via said inlet opening and transporting at least part of the deactivating material with the air via the outlet opening,
wherein said deactivating material comprises at least 80 wt. % of one or more of a terpene and a terpenoid having no aliphatic unsaturated bond, with a concentration of the deactivating material in air in said space at a level selected from the range of 0.001-1 mg/m3.

US Pat. No. 10,596,290

FORMED THREE-DIMENSIONAL MATRIX AND ASSOCIATED COATING PROVIDING MODULATED RELEASE OF VOLATILE COMPOSITIONS

Enviroscent, Inc., Atlan...

1. An aggregate article comprising:a plurality of scent reservoirs comprising an absorbent matrix material, the plurality of scent reservoirs constructed into a three-dimensional matrix via a modulating coating bonding between the plurality of scent reservoirs;
a volatile composition, wherein at least some of the volatile composition is located in the internal structure absorbent matrix material;
wherein the modulating coating also substantially covers each of the plurality of scent reservoirs and comprises a barrier substance and hygroscopic silica having a diameter ranging from 1 nm to 100 nm;
wherein the barrier substance hinders a release of the volatile composition through the modulating coating; and
wherein the hygroscopic silica facilitates the release of the volatile composition through the modulating coating.

US Pat. No. 10,596,287

APPARATUS AND METHOD TO LINK MEDICAL DEVICE STERILIZATION EQUIPMENT

ASP GLOBAL MANUFACTURING ...

1. A communication hub comprising:(a) a processor;
(b) a memory configured to store instructions executable by the processor; and
(c) a network interface configured to place the communication hub in communication with a plurality of devices over a network;
wherein the processor is programmed to execute instructions to:
(i) receive a first set of device configurations from a user device,
(ii) create a device record for a first medical device processing component based upon the first set of device configurations,
(iii) establish a network connection to the first medical device processing component via the network interface,
(iv) provide a first set of device information to the user device, wherein the first set of device information is received from the first medical device processing component, and
(v) provide a task record to a second medical device processing component, wherein the task record describes a first task performed by the first medical device processing component, and wherein the first task is associated with sterilizing a medical device;
wherein the first set of device information is configured to cause the user device to display at least a portion of the first set of device information via a display of the user device, and
wherein the task record is required by the second medical device processing component in order to perform a second task associated with sterilizing the medical device.

US Pat. No. 10,596,285

STERILIZING METHOD

Ushio Denki Kabushiki Kai...

1. A sterilization method comprising:irradiating an air serving as an ozone raw material gas with light for producing ozone which does not include light with a wavelength region where the light decomposes ozone and which has a wavelength of about 172 nm to not more than 200 nm, to obtain an ozone-containing air; and
exposing an object to be sterilized to the ozone-containing air, thereby subjecting the object to a sterilization treatment, wherein
the ozone raw material gas has a relative humidity of 20% RH to not more than 60% RH.

US Pat. No. 10,596,284

CHLORINE DIOXIDE DECONTAMINATION SYSTEM AND METHODS

Controlled Performance wi...

1. A fumigant activation unit for a chlorine dioxide (ClO2) decontamination system, comprising:an activation chamber;
a fumigant activator in fluid communication with the activation chamber, wherein the fumigant activator is operable to selectively provide water to the activation chamber and to blow air through the activation chamber;
an activation pouch positioned in the activation chamber so as to be exposed to the air blowing through the activation chamber, wherein the activation pouch is adapted to receive water provided by the fumigant activator and reagents adapted to generate ClO2 gas, and wherein the activation pouch is adapted to release ClO2 gas generated by a reaction solution of the reagents and water into the air blowing through the activation chamber to form a decontamination fumigant; and
a back plate in fluid communication with the activation chamber and adapted to direct the decontamination fumigant to an area to be decontaminated, wherein the back plate is selectively adjustable to interface the fumigant activation unit with the area to be decontaminated in any of a plurality of selected orientations;
wherein the activation chamber, fumigant activator, and back plate are interconnected as an integral sealed unit.

US Pat. No. 10,596,282

STERILIZATION DEVICE UTILIZING LOW INTENSITY UV-C RADIATION AND OZONE

Hepco Holdings, LLC, Sem...

12. A system for killing Methicillin-resistant Staphylococcus aureus (MRSA) pathogens, the system comprising:an enclosure;
one or more ultraviolet emitters housed in the enclosure and covered by a filter, the filter passing ultraviolet light from the one or more ultraviolet emitters, the one or more ultraviolet emitters configured to emit ultraviolet light from the housing, through the filters, and onto a zone of a surface of a metallic object where ozone is produced by ultra violet light emitted from the one or more ultraviolet emitters for killing Methicillin-resistant Staphylococcus aureus (MRSA) pathogens;
means for detecting proximity to the surface of the metallic object by way of a magnetic sensor, the means for detecting proximity prevents the one or more ultraviolet emitters from emitting the ultraviolet light until the system for killing the Methicillin-resistant Staphylococcus aureus (MRSA) pathogens is at the surface; and
a timer configured to connect a source of power to the one or more ultraviolet emitters for a period of time responsive to the means for detecting the surface indicating contact with the surface, the period of time sufficient for killing Methicillin-resistant Staphylococcus aureus (MRSA).

US Pat. No. 10,596,281

STERILIZING TOUCH SCREEN DISPLAYS WITH ULTRAVIOLET LIGHT

Rockwell Collins, Inc., ...

1. A computer apparatus comprising:a touch screen display device;
a plurality of light-emitting diodes (LEDs) disposed along at least one edge of the touch screen display device, a first set of the plurality of LEDs disposed at a first angle to and above a first edge, and a second set of the plurality of LEDs disposed at a second angle to and above the first edge;
at least one processor in data communication with the plurality of LEDs and with a memory storing processor executable code for configuring the at least one processor to:
activate the plurality of LEDs for a predetermined period of time to sterilize a touch screen display device with ultraviolet (UV) light during a startup operation; and
periodically activate the plurality of LEDs for the predetermined period of time to sterilize the touch screen display device with UV light during operation.

US Pat. No. 10,596,272

VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 5

1. A saccharide of general formula (I)
wherein
R1 is selected from —R2, —R4,

R2 represents

R3 is selected from —H, —CH3, —C2H5, —C3H7, —C4H9 and —CF3;
R4 represents R6 or

R5 represents —H or

R6 represents —O-L-NH2;
R7 and R8 are independently of each other selected from —H and —OH and cannot be simultaneously —H;
R7 and R8 can form together with the carbon atom to which they are attached to a carbonyl group C?O;
R23 is selected from —H, —C(O)CH3, —C(O)CF3 and —C(O)CCl3;
-L- is selected from: —CH2—, —(CH2)2—, —(CH2)3—, —(CH2)4—, —(CH2)5—, —(CH2)6—, —(CH2)7—, —(CH2)8—, —(CH2)9—, —(CH2)10—, —CF2—, —(CF2)2—, —(CF2)3—, —(CF2)4—, —(CF2)5—, —(CF2)6—, —(CF2)7—, —(CF2)8—, —(CF2)9—, —(CF2)10—, —(CH2)2—O—(CH2)2—, —CH2—O—(CH2)3—, —(CH2)3—O—CH2—, —CH2—O—(CH2)2—, —(CH2)2—O—CH2—, —(CH2)3—O—(CH2)2—, —(CH2)2—O—(CH2)3—, —(CH2)4—O—CH2—, —CH2—O—(CH2)4—, -La-, -La-Le-, -La-Lb-Le-, -La-Lb-Ld-Lc-Le, -La-Ld-Le;
wherein
-La- is selected from: —(CH2)m, —(CF2)m, —(CH2—CH2—O)m—C2H4—, —(CH2—CH2—O)m—CH2—, —(CR10R11)m—,

-Lb- and -Lc- are independently of each other selected from: —O—, —S—, —NH—C(O)—NH—, —NH—C(S)—NH—, —NH—C(O)—, —C(O)—NH—, —NH—C(O)—O—, —NR9—, —NR18—, —SO2—,

-Ld- represents —(CH2)n—, —(CF2)n—, —(CR12R13)n—, —(CH2—CH2—O)n—C2H4—, —(CH2—CH2—O)n—CH2—,

-Le- is selected from: —(CH2)p1—, —(CF2)p1—, —C2H4—(O—CH2—CH2)p1—, —CH2—(O—CH2—CH2)p1—, —(CH2)p1—O—(CH2)p2—, —(CH2)p1—S—(CH2)p2—, —(CR14R15)p1—, —(CR14R15)p1—O—(CR21R22)p2—, —(CR14R15)p1—S—(CR21R22)p2—,

R9 and R18 are independently of each other selected from: —CH3, —C2H5, —C3H7, and —C(O)CH3;
R10, R11, R12, R13, R14, R15, R16, R17, R19, R20, R21 and R22 are independently of each other selected from: —H, —F, —Cl, —CH3, —C2H5, —C3H7, —C5H9, —C6H13, —OCH3, —OC2H5, —CH2F, —CHF2, —CF3, —C(O)—NH2, —SCH3, —SC2H5, —NHC(O)CH3, —N(CH3)2 and —N(C2H5)2;
m, n, p1 and p2 are independently of each other an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10;
and pharmaceutically acceptable salts thereof.

US Pat. No. 10,596,269

DELIVERING ENHANCED ACTIVE AGENTS

Mamoun M. Alhamadsheh, S...

1. A method of administering an enhanced active agent to a subject, the method comprising: obtaining a conjugated active agent including an active agent and a delivery system for the agent, the delivery system having;a ligand that is selective for transthyretin in the serum of the subject; and,
a linker configured for operatively attaching the ligand covalently to the active agent, the linker selected to cause release of the active agent from the transthyretin in the subject as the conjugated active agent, wherein the linker ranges from 14-20 angstroms in length;
wherein, the delivery system has a structure comprising:

where,
n is 1 to 8;
R1 and R3 are independently selected from a short chain alkyl having 1 to 4 carbon atoms;
R2 is selected from the group consisting of a hydrogen, a short chain alkyl having 1 to 4 carbon atoms, and an aryl;
Xa is C(R4)(R5), O, N—R5, or S; where R4 and R5 are independently selected from hydrogen, an alkyl having 1 to 4 carbon atoms, a substituted alkyl, an alkoxy, hydroxyl, an alkoxycarbonyl, an an amino;
Ra is CHO, COOH, COOCH3, COOR6, CONR7R8, tetrazolyl, CONHOH, B(OH)2, CONHSO2Ar, CONHCH(R9)COOH, halogen, acyl, substituted acyl, carboxyl, heterocyclic group, sulfonamide, sulfonyl fluoride, thioester, alkoxycarbonyl or substituted alkoxycarbonyl;
Rb is the linker and is positioned ortho or meta to Ra, the linker including a CHO, COOH, COOCH3, COOR6, CONR7R8, tetrazolyl, CONHOH, B(OH)2, CONHSO2Ar, CONHCH(R)COOH, CF3, hydrogen, halogen, alkyl, substituted alkyl, acyl, substituted acyl, carboxyl, heterocyclic group, sulfonamide, sulfonyl fluoride, ester, thioester, ether, thioether, triazolyl, alkoxycarbonyl or substituted alkoxycarbonyl;
R6 is alkyl, haloalkyl, cycloalkyl, or heterocyclyl;
R7 and R8 are each independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, or heteroaryl; and,
R9 is the side chain of a naturally occurring ?-amino carboxylic acid;
or, a pharmaceutically acceptable salt, ester, enol ether, enol ester, amide, acetal, ketal, orthoester, hemiacetal, hemiketal, hydrate, solvate or prodrug thereof; and administering the conjugated active agent to the subject.

US Pat. No. 10,596,268

CONJUGATE OF DEZOCINE AND POLYETHYLENE GLYCOL

JENKEM TECHNOLOGY CO., LT...

1. A conjugate of dezocine and polyethylene glycol having the following structure:
wherein, Y is selected from: H or a protecting group; and
m1, m2, m3, m4, m5, m6, m7, m8 and m9 are independently selected from integers of 0-20.

US Pat. No. 10,596,264

PEPTIDES WITH VIRAL INFECTION ENHANCING PROPERTIES AND THEIR USE

Genethon, Evry (FR) Cent...

1. A method for promoting the infection of an eukaryotic cell by a virus or a viral particle, comprising contacting a cell or a subject in need thereof with the virus or viral particle and with a peptide having the sequence of SEQ ID NO: 14.

US Pat. No. 10,596,262

POLYMER COMPOSITIONS IN BIOMEDICAL APPLICATIONS

TRGel, LLC, Mission Viej...

1. A biomedically useful composition comprising:a C2-C3 linked polyether of a 1,6:3,3-dianhydrohexapyranose comprising one or more monomeric units selected from the group consisting of a monomeric unit of the structural formula
a monomeric unit of the structural formulaand a monomeric unit of the structural formulawherein R1, R2, R3, R4, R5, R6, R7 and R8 are moieties that to render said C2-C3 linked polyether insoluble in aqueous media chosen from the group consisting of:and, further comprising an effective amount of at least one bioactive agent.

US Pat. No. 10,596,261

COPROCESSED SILICA COATED POLYMER COMPOSITION

1. A coprocessed excipient comprising:about 90.0% to about 99.9% of w/w a vinyl lactam derived polymer comprising a monomer selected from the group consisting of N-vinyl-2-pyrrolidone, N-vinyl-2-caprolactam, N-vinyl-3-methyl-2-pyrrolidone, N-vinyl-3-methyl-2-caprolactam, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl-4-methyl-2-caprolactam, N-vinyl-5-methyl-2-pyrrolidone, N-vinyl-5,5-dimethyl-2-pyrrolidone, N-vinyl-3,3,5 -trimethyl-2-pyrrolidone, N-vinyl-5-methyl-5-ethyl-2-pyrrolidone, N-vinyl-3,4,5-trimethyl-3-ethyl-2-pyrrolidone, N-vinyl-7-methyl-2-caprolactam, N-vinyl-7-ethyl-2-caprolactam, N-vinyl-3,5-dimethyl-2-caprolactam, N-vinyl-4,6-dimethyl-2-caprolactam, N-vinyl-3,5,7-trimethyl-2-caprolactam, and combinations thereof; and
about 0.1% w/w to about 10.0% w/w of a deagglomerated coprocessing agent comprising a silica having a particle size less than 500 nm, where the coprocessing agent is deagglomerated using shear in magnitude of at least 0.01 kW-hour/kilogram;
wherein the coprocessed excipient is prepared in a continuous process, where the coprocessing results in silica coating of the vinyl lactam derived polymer, and the coprocessed excipient has a Brookfield cohesion of less than 0.12 kPa and a bulk density of at least 0.249 gram/milliliter,
wherein the silica is selected from the group consisting of a fumed silica, a colloidal silica, a silicon dioxide, a calcium silicate and combinations thereof.

US Pat. No. 10,596,222

COMBINATION THERAPY WITH PEPTIDE EPOXYKETONES

ONYX THERAPEUTICS, INC., ...

1. A method of treating multiple myeloma in a patient, the method comprising administering to the patient in need of treatment a combination of: (a) melphalan, and (b) an effective amount of an epoxy ketone proteasome inhibitor having the structure of
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,596,221

CONTROLLED-RELEASE FERTILIZER COMPRISING OXIDIZED GLUTATHIONE

KANEKA CORPORATION, Osak...

8. A method for growing a plant, comprising applying a controlled-release fertilizer to the plant,wherein the controlled-release fertilizer comprises:
0.000001% to 20% by mass of oxidized glutathione;
0.01% to 20% by mass of carboxymethyl cellulose or a salt thereof; and
60% to 99.98% by mass of an inorganic porous material.

US Pat. No. 10,596,220

SMAC MIMETIC

Medivir AB, Huddinge (SE...

1. A method for treating cervical cancer in a mammal in need thereof that comprises administering to said mammal an effective amount of Compound 15 of the following formula:wherein R5 is —CH2CH3, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,596,213

FRUIT OR VEGETABLE POMACE COMPOSITION AND USE AS BLOOD GLUCOSE MODULATOR AND ANTI-DIABETIC AGENT

Brandeis University, Wal...

1. A method of maintaining or achieving normal blood glucose concentration in response to a diabetogenic diet in a mammalian subject, the method comprising periodically administering to the mammalian subject consuming the diabetogenic diet a nutritional composition comprising a therapeutically effective amount of carrot pomace, whereby the subjects blood glucose concentration is maintained within a normal range or achieves a value within a normal range.

US Pat. No. 10,596,198

DEVICES FOR SELECTIVELY RELEASING VOLATILE COMPOUNDS

Vium, Inc., San Mateo, C...

14. An apparatus for releasing compounds into a living space of an experimental animal, the apparatus comprising:a cage comprising one or more walls that enclose a living space for an experimental animal;
a card adapted to be positioned inside the cage or in an air supply pathway to the cage, the card comprising a plurality of compound-sequestering structures to release compounds into the living space of the cage;
a heating structure adapted to be positioned outside the cage, the heating structure comprising a two-dimensional array of laser or infrared sources adapted to align with the respective compound-sequestering structures and selectively direct their outputs toward the respective compound-sequestering structures; and
a controller configured to independently control an intensity of emission from each of the laser or infrared sources to cause a corresponding compound-sequestering structure to release compounds into the atmosphere of the living space.

US Pat. No. 10,596,191

POLYMER CONJUGATE OF HEXA-COORDINATED PLATINUM COMPLEX

Nippon Kayaku Kabushiki K...

1. A polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded directly to a side-chain carboxyl group of the block copolymer,wherein the polymer conjugate is represented by the following Formula (I):

wherein R1 represents a methyl group; R2 represents a trimethylene group; R3 represents an acetyl group; R4 represents a residue of a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions; R5 represents a substituent selected from the group consisting of a residue obtained by eliminating H from an amino group of phenylalanine benzyl ester, and —NR9CONHR10; and R9 and R10 both represent a cyclohexyl group or an isopropyl group; a represents an integer from 5 to 11,500; d, e, f, g, h, i, and j each represents an integer from 0 to 200; d+e represents an integer from 1 to 200; d+e+f+g+h+i+j represents an integer from 2 to 200; and the bonding order of the various constituent units of the polyaspartic acid is arbitrary.

US Pat. No. 10,596,187

THERAPEUTIC COMPOSITIONS

Yale University, New Hav...

1. An oral rehydration composition for addition to water comprising:a salt composition;
a fermentable acetylated type IV resistant starch in an amount of 35 g/L to 60 g/L that is acetylated to a substitution value of up to and including 2.5%, and has an amylose content of at least 70% w/w;
xanthan gum in an amount of 1 g/L to 3 g/L to suspend the fermentable acetylated type IV resistant starch in water; and
optionally one or more of:
glucose;
water soluble salts of zinc, magnesium or copper;
sodium bicarbonate; and
combinations thereof.

US Pat. No. 10,596,172

2,4-DISUBSTITUTED PYRIMIDINES USEFUL AS KINASE INHIBITORS

Celgene CAR LLC, Pembrok...

1. A method for inhibiting the activity of one or more of ErbB1, ErbB2, ErbB3, or ErbB4, or a mutant thereof, in a patient or in a biological sample comprising the step of administering to said patient or contacting said biological sample with a compound selected from the group consisting of:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,596,163

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

ChemoCentryx, Inc., Moun...

1. A compound or salt thereof of formula (II):
wherein:
R1 is selected from the group consisting of substituted or unsubstituted C2-8 alkyl, substituted or unsubstituted C1-8 alkoxy, unsubstituted C1-8 alkylamino, and substituted or unsubstituted C3-10 heterocyclyl; and
R2 is H, F, Cl, or substituted or unsubstituted C1-8 alkoxy; or
R1 and R2 together with the carbon atoms to which they are attached form a non-aromatic carbocyclic ring or a heterocyclic ring;
R3 is H, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C1-8 alkoxy, or halo;
R4 is H or F;
R5 is H, F, Cl, or —CH3; and
R6 is H, halo, —CN, —CO2Ra, —CONH2, —NH2, unsubstituted C1-8 aminoalkyl, substituted or unsubstituted C1-8 alkyl, or substituted or unsubstituted C1-8 alkoxy, wherein Ra is H or substituted or unsubstituted C1-8 alkyl; or
R5 and R6 together with the carbon atoms to which they are attached form a carbocyclic ring;
L is a bond, —CH2—, or —CH(CH3)—;
Z is selected from the group consisting of

and N-oxides thereof;
the Z group is unsubstituted or substituted with 1 to 3 independently selected R8 substituents;
each R8 is independently selected from the group consisting of H, halo, —CN, —OH, oxo, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C1-8 alkoxy, —NR20R21, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heterocyclyl;
R20 and R21 are each independently H or substituted or unsubstituted C1-8 alkyl,
wherein substituents for substituted alkyl including the alkyl portions of aminoalkyl, alkylamino, and alkoxy are independently selected from: halogen, —CN, —CO2R?, —C(O)R?, —C(O)NR?R?, oxo (?O or —O?), —OR?, —OC(O)R?, —OC(O)NR?R?, —NO2, —NR?C(O)R?, —NR??C(O)NR?R?, —NR?R?, —NR?CO2R?, —NR'S(O)R?, —NR'S(O)2R??, —NR??S(O)NR?R?, —NR??S(O)2NR?R?, —SR?, —S(O)R?, —S(O)2R?, —S(O)2NR?R?, —NR?—C(NHR?)?NR??, —SiR?R?R??, —OSiR?R?R??, —N3, unsubstituted C6-10 aryl, unsubstituted 5- to 10-membered heteroaryl, and unsubstituted 3- to 10-membered heterocyclyl;
wherein the number of substituents is from zero to (2m?+1), where m? is the total number of carbon atoms in the alkyl, alkenyl, and alkynyl group;
wherein substituents for substituted aryl, heterocyclyl, and heteroaryl are independently selected from halogen, —CN, —CO2R?, —C(O)R?, —C(O)NR?R?, oxo (?O or —O?), —OR?, —OSiR?R?R??, —OC(O)R?, —OC(O)NR?R?, —NO2, —NR?C(O)R?, —NR??C(O)NR?R?, —NR?R?, —NR?CO2R?, —NR'S(O)R?, —NR'S(O)2R?, —NR??S(O)NR?R?, —NR??S(O)2NR?R?, —SR?, —S(O)R?, —S(O)2R?, —S(O)2NR?R?, —NR?—C(NHR?)?NR??, —SiR?R?R??, —N3, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl, unsubstituted C6-10 aryl, unsubstituted 5- to 10-membered heteroaryl, and unsubstituted 3- to 10-membered heterocyclyl;
wherein the number of possible substituents to substituted aryl, heterocyclyl, and heteroaryl is from 0 to the total number of open valences on the ring system; and
wherein R?, R? and R?? are each independently hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, or unsubstituted C2-8 alkynyl.

US Pat. No. 10,596,158

SOLID FORMS OF {[5-(3-CHLOROPHENYL)-3-HYDROXYPYRIDINE-2-CARBONYL]AMINO}ACETIC ACID, COMPOSITIONS, AND USES THEREOF

Akebia Therapeutics, Inc....

1. A method for preparing a crystalline Compound (I):
a) preparing a solution of a Compound (I) in an organic solvent that is acetone;
b) bringing the solution to super-saturation to cause formation of crystals; and
c) isolating the crystals.

US Pat. No. 10,596,157

ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE

Nissan Chemical Corporati...

1. A method for protecting a mammal from a flea comprising orally administering to the mammal a pesticidally effective amount sufficient to protect the mammal from the flea of a compound of Formula (1) or a salt thereof,
wherein
A1, A2 and A3 independently of one another are carbon atom;
G is benzene ring;
W is oxygen atom or sulfur atom;
X is halogen atom, C1-C6 alkyl, C1-C6 alkyl arbitrarily substituted with R4, —OR5 or —S(O)rR5;
Y is halogen atom, C1-C6 alkyl, or —S(O)rR5;
R1 is C1-C6 alkyl arbitrarily substituted with R16, C3-C6 cycloalkyl, C3-C6 alkenyl, C3-C6 haloalkenyl, —N(R20)R19, —C(O)N(R10)R9, —C(S)N(R10)R9, phenyl substituted with (Z)p1, D-15, D-47, D-50, D-51, E-4, E-5, E-6, E-9 or E-23, wherein
D-15, D-47, D-50, and D-51 are aromatic heterocyclic rings of the following formulae, respectively

 and
E-4, E-5, E-6, E-9 and E-23 are saturated heterocyclic rings of the following formulae, respectively

R2 is hydrogen atom, C1-C6 alkyl, C1-C6 haloalkyl, C1-C4 alkoxy C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 alkynyl, —C(O)R9 or —C(O)OR9;
R3 is C1-C6 haloalkyl;
R4 is halogen atom;
R5 is C1-C6 alkyl, C1-C6 haloalkyl;
R9 is C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy C1-C4 alkyl, C3-C6 alkenyl;
R10 is hydrogen atom;
R15 is C1-C6 alkyl;
R16 is halogen atom, cyano, C3-C6 cycloalkyl, —OR25, —S(O)rR27, —C(O)R28, —C(O)OR28, —C(O)NHR29, —C(O)N(R29)R28, —C(R31)?NOR30, phenyl, D-1, D-3, D-10, D-17, D-21, D-22, D-23, D-31, D-34, D-35, D-38, D-47, D-48, D-49, D-50, D-51, D-53, E-4 or E-10, wherein
D-1, D-3, D-10, D-17, D-21, D-22, D-23, D-31, D-34, D-35, D-38, D-47, D-48, D-49, D-50, D-51, and D-53 are aromatic heterocyclic rings of the following formulae, respectively

 and
E-4 and E-10 are saturated heterocyclic rings of the following formulae, respectively

R19 is —C(O)OR28, phenyl, D-47 or D-50, wherein
D-47 and D-50 are aromatic heterocyclic rings of the following formulae, respectively

R20 is hydrogen atom, C1-C6 alkyl;
R22 is C1-C6 alkoxy or two R22s present on the same carbon atom may together form oxo;
R23 is C1-C6 alkyl substituted with R32;
R25 is hydrogen atom, C1-C6 alkyl or C1-C6 haloalkyl;
R27 is C1-C6 alkyl;
R28 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 alkenyl or C3-C6 alkynyl;
R29 is hydrogen atom or C1-C6 alkyl;
R30 is C1-C6 alkyl;
R31 is C1-C6 alkyl;
R32 is halogen atom;
Z is halogen atom, C1-C6 alkyl or C1-C6 haloalkyl;
m is an integer of 0 to 5;
n is an integer of 0 to 4;
p1 is an integer of 1 to 5;
p2 is an integer of 0 to 4;
p3 is an integer of 0 to 3;
p4 is an integer of 0 to 2;
p5 is an integer of 0 or 1;
q2 is an integer of 0 to 5;
q3 is an integer of 0 to 7;
q4 is an integer of 0 to 9;
r is an integer of 0 to 2; and
t is an integer of 0 or 1.

US Pat. No. 10,596,156

PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF

BOEHRINGER INGELHEIM ANIM...

1. A soft chewable veterinary composition for treating and/or preventing a parasitic infection or infestation in an animal comprising:a) a combination of:
(i) at least one isoxazoline active agent of Formula (I):
wherein:A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting of CR3 and N, provided that at most 3 of A1, A2, A3, A4, A5 and A6 are N;
B1, B2 and B3 are independently selected from the group consisting of CR2 and N;
W is O or S;
R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R6;
each R2 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, C2-C4 alkoxycarbonyl, —CN or —NO2;
each R3 is independently H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, —CN or —NO2;
R4 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl, C4-C7 cycloalkylalkyl, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl;
R5 is H, OR10, NR11R12 or Q1; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R7; or
R4 and R5 are taken together with the nitrogen to which they are attached to form a ring containing 2 to 6 atoms of carbon and optionally one additional atom selected from the group consisting of N, S and O, said ring optionally substituted with 1 to 4 substituents independently selected from the group consisting of C1-C2 alkyl, halogen, —CN, —NO2 and C1-C2 alkoxy;
each R6 is independently halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, —CN or —NO2;
each R7 is independently halogen; C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 alkylamino, C2-C8 dialkylamino, C3-C6 cycloalkylamino, C2-C7 alkylcarbonyl, C2-C7 alkoxycarbonyl, C2-C7 alkylaminocarbonyl, C3-C9 dialkylaminocarbonyl, C2-C7 haloalkylcarbonyl, C2-C7 haloalkoxycarbonyl, C2-C7 haloalkylaminocarbonyl, C3-C9 dihaloalkylaminocarbonyl, hydroxy, —NH2, —CN or —NO2; or Q2;
each R8 is independently halogen, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, C2-C4 alkoxycarbonyl, —CN or —NO2;
each R9 is independently halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, C1-C6 alkylamino, C2-C6 dialkylamino, —CN, —NO2, phenyl or pyridinyl;
R10 is H; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one of more halogen;
R11 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl, C4-C7 cycloalkylalkyl, C2-C7 alkylcarbonyl or C2-C7 alkoxycarbonyl;
R12 is H; Q3; or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R7; or
R11 and R12 are taken together with the nitrogen to which they are attached to form a ring containing 2 to 6 atoms of carbon and optionally one additional atom selected from the group consisting of N, S and O, said ring optionally substituted with 1 to 4 substituents independently selected from the group consisting of C1-C2 alkyl, halogen, —CN, —NO2 and C1-C2 alkoxy;
Q1 is a phenyl ring, a 5- or 6-membered heterocyclic ring, or an 8-, 9- or 10-membered fused bicyclic ring system optionally containing one to three heteroatoms wherein said one to three heteroatoms comprise up to 1 O, up to 1 S and up to 3 N, each ring or ring system optionally substituted with one or more substituents independently selected from R8;
each Q2 is independently a phenyl ring or a 5- or 6-membered heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from R9;
Q3 is a phenyl ring or a 5- or 6-membered heterocyclic ring, each ring optionally substituted with one or more substituents independently selected from R9; and
n is 0, 1 or 2; and
(ii) at least one systemically-acting active agent, wherein the systemically active agent is one or more avermectins, one or more milbemycins, one or more spinosyn compounds, one or more spinosoid compounds, one or more benzimidazoles, levamisole, pyrantel, morantel, praziquantel, closantel, clorsulon, one or more amino acetonitrile active agents, one or more depsipeptides, one or more insect growth regulators, one or more neonicotinoids, one or more arylpyrazoles or one or more aryloazol-2-yl cyanoethylamino active agents, or a combination of different agents thereof; and
b) a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier comprises:
i) a surfactant which is a polyethylene glycol stearate or a polyethylene glycol hydroxystearate;
ii) one or more fillers;
iii) one or more binders; and
iv) at least one humectant, solvent or lubricant, or a combination thereof; wherein said fillers, binders, humectant, solvent and lubricant are different compounds.

US Pat. No. 10,596,153

ANTIMICROBIAL AGENTS AND THE METHOD OF SYNTHESIZING THE ANTIMICROBIAL AGENTS

Arkansas State University...

1. A composition comprising a compound having a formulaor a salt thereof;wherein R1 is selected from fluorine, a branched or unbranched, substituted or unsubstituted C2-C12 alkyl, methoxy, nitrogen dioxide, carboxyl, sulfonamide, tetrazole, triazole, or trifluoromethyl;
wherein R2 is selected from hydrogen, fluorine, chlorine, bromine, a branched or unbranched, substituted or unsubstituted C1-C12 alkyl, methoxy, nitrogen dioxide, carboxyl, or trifluoromethyl;
wherein R3 is selected from hydrogen, a branched or unbranched, substituted or unsubstituted C1-C6 alkyl, phenyl, aryl, trifluoromethylphenyl, halophenyl, coumarinyl, hydroxycoumarinyl, naphthalinyl, or methoxy naphthalinyl;
wherein R4 is selected from a branched or unbranched, substituted or unsubstituted C1-C6 alkyl, phenyl, aryl, trifluoromethylphenyl, halophenyl, coumarinyl, hydroxycoumarinyl, naphthalinyl, or methoxy naphthalinyl; and
wherein R5 is selected from hydrogen or methyl.

US Pat. No. 10,596,152

SELENIUM CONTAINING KGA/GDH DUAL INHIBITORS AND THE APPLICATIONS THEREOF

HANGZHOU GAMMA BIOTECH CO...

1. A composition of selenium-containing inhibitors that bind to the allosteric site of glutaminase and/or inhibit glutamate dehydrogenase, selected from the following compounds:
Wherein:
R, R1, R2 are independently selected substituents comprising aromatic heterocycle, heterocycle, substituted alkyl, lipid, amide, ether, halogen, silane, thioether, amine, phosphate group, and sulfoxide.

US Pat. No. 10,596,144

TREATING OR PREVENTING NEPHROGENIC DIABETES INSIPIDUS

Emory University, Atlant...

1. A method of preventing nephrogenic diabetes insipidus comprising administering an effective amount of an AMPK activator in combination with lithium to a subject in need thereof.

US Pat. No. 10,596,140

PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES

Alkermes Pharma Ireland L...

1. A compound having the formulaor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,596,133

TREATMENT OF CANCER WITH SPECIFIC RXR AGONISTS

Io Therapeutics, Inc., H...

1. A method of treating a cervical cancer comprising administering to a patient in need of such treatment a retinoid X receptor (RXR) agonist at a dose below its Retinoic Acid Receptor (RAR) activating threshold and at or above its RXR effective dose, the RXR agonist has a chemical structure
or a pharmaceutically acceptable salt thereof; where R is H or lower alkyl of 1 to 6 carbons, and the dose of the RXR agonist is from about 0.1 to about 20 mg/m2/day.

US Pat. No. 10,596,125

NANOWIRE-COATED MICRODEVICE AND METHOD OF MAKING AND USING THE SAME

The Regents of the Univer...

1. A method of forming a microdevice comprising a plurality of nanowires on a biocompatible surface, comprising:a) depositing onto a surface of a first planar biocompatible polymeric layer a second planar biocompatible polymeric layer, wherein the melting temperature of the first biocompatible polymeric layer is higher than the melting temperature of the second biocompatible polymeric layer;
b) contacting a surface of the second planar biocompatible polymeric layer with a nanoporous membrane; and
c) forming the second planar biocompatible polymeric layer into a plurality of nanowires using the nanoporous membrane as a template,
wherein the nanowires are present on only one surface of the microdevice.

US Pat. No. 10,596,088

ORAL CARE COMPOSITIONS FOR PROMOTING GUM HEALTH

1. An oral care composition comprising:a) a stannous ion source; and
b) citrulline in free or salt form;
wherein the oral care composition has a pH of 7.2 or less.

US Pat. No. 10,596,072

MEDICATION DISPENSING SYSTEM

DOSE HEALTH, LLC, Maple ...

1. A medication dispensing system comprising:a cassette having a plurality of separated chambers, with each chamber being configured to contain a plurality of medications;
a housing containing the cassette and accommodating the controlled access to a predetermined chamber, the housing comprising a base and a movable cover, wherein the movable cover has an access opening which is positionable above any one of the plurality of separated chambers;
an accelerometer positioned within the housing and configured to detect an orientation of the housing;
a drive mechanism coupled to the base and the movable cover to control movement of the cassette relative to the base;
a user interface coupled to the housing, the user interface capable of presenting information and receiving commands; and
a control system operatively coupled to the user interface and the drive mechanism, the control system configured to engage the drive mechanism only when the accelerometer detects a desired orientation and based upon a dispensing schedule having a plurality of dispensing events stored in the control system, wherein each one of the plurality of dispensing events comprises a dispensing type and dispensing time, by generating appropriate drive control signals in response to the one of the dispensing events, which causes the drive mechanism to engage to position the access opening and the designated chamber adjacent one another.

US Pat. No. 10,596,064

CPR CHEST COMPRESSION SYSTEM WITH TONOMETRIC INPUT AND FEEDBACK

ZOLL Medical Corporation,...

1. A system for providing CPR (cardiopulmonary resuscitation) compressions on a cardiac arrest victim, said system comprising:a chest compressor comprising a motor within a housing, the chest compressor configured to repetitively compress the chest of the cardiac arrest victim and generate compression-induced pulse pressure waves;
a tonometric sensor operable to detect the compression-induced pulse waves and produce pulse wave signals corresponding to each of the compression-induced pulse pressure waves;
at least one processor configured to:
control the chest compressor to generate a plurality of test chest compression sets comprised of chest compression parameters, wherein each test compression set includes at least one modified chest compression parameter, wherein the at least one modified chest compression parameter affects one or more waveform features of the compression induced pulse waves, the one or more waveform features including: a pseudo-reflective notch, and at least one of: a systolic pressure time integral (SPTI) value, a diastolic pressure time integral (DPTI) value, and a shelf;
receive the pulse wave signals and determine a one or more waveform for each of the pulse wave signals, and further identify the one or more waveform features of the pulse pressure waveforms;
identify which of the test compression sets resulted in the received pulse pressure waveforms having the one or more waveform features comprising the pseudo-reflective notch,
determine which of the identified test compression sets resulted in improved compression-induced blood flow based on at least one of: the SPTI value, DPTI value, and the shelf; and
operate the chest compressor according to the determined test compression sets that resulted in the improved compression-induced blood flow.

US Pat. No. 10,596,062

VISUAL REHABILITATION SYSTEMS AND METHODS

MAGNO PROCESSING SYSTEMS,...

1. A visual rehabilitation system, comprising:a virtual reality (VR) device;
a processor; and
a computer readable medium having computer-executable instructions comprising at least one visual rehabilitation program that, when executed by the processor, cause the processor to perform a visual rehabilitation method including causing the VR device to stimulate a magnocellular pathway of a user in isolation by visually presenting to the user one or more images, wherein the one or more of images are selected from a group consisting of the following: checkerboards, horizontal stripes, vertical stripes, horizontal sinusoidal stripes, and vertical sinusoidal stripes.

US Pat. No. 10,596,061

MOBILITY AID MONITORING SYSTEM WITH MOTION SENSOR AND TRANSCEIVER

Auto-Pilot Medical Techno...

1. A method comprising:receiving data generated by a monitoring device for a mobility aid, including interval summaries having cumulative motion information detected by a motion sensor of the monitoring device and indicative of motion of the mobility aid during a corresponding interval of time;
determining that the data satisfies an alert condition, including:
determining a current inactivity streak value for motion of the mobility aid based on the received data, wherein the inactivity streak value is a time value that represents a number of intervals in which no motion of the mobility aid is detected;
comparing the current inactivity streak value to an inactivity threshold; and
determining the current inactivity streak value exceeds the inactivity threshold; and
generating an alert based on the alert condition being satisfied.

US Pat. No. 10,596,060

FRAME ASSEMBLY AND MOTION ASSISTANCE APPARATUS INCLUDING THE SAME

Samsung Electronics Co., ...

1. A motion assistance apparatus comprising: a back support configured to support a back of a user; a driver on one side of a joint of the user; and a frame assembly including a plurality of longitudinal members each having first ends connected to the driver and second ends connected to the back support such that a stiffness of the plurality of longitudinal members collectively increases from an intermediate portion thereof between the first ends and the second ends towards each of the first ends and the second ends, the plurality of longitudinal members including, a first longitudinal member configured to connect to back support and the driver, a second longitudinal member configured to connect to back support and the driver such that the second longitudinal member and the first longitudinal member are separated by a distance, and a third longitudinal member configured to diagonally connect the first longitudinal member and the second longitudinal member.

US Pat. No. 10,596,059

DEVICE AND METHOD FOR STRENGTHENING THE ARMS OF HUMAN EXOSKELETONS

Ekso Bionics, Inc., Rich...

1. An exoskeleton comprising:an arm brace configured to be coupled to and extend across an elbow of an arm of a wearer;
a tensile member connected to the arm brace;
an actuator configured to exert a pulling force on the tensile member, wherein the pulling force reduces a length of the tensile member between the arm brace and the actuator and causes the arm of the wearer to bend at the elbow; and
a torso brace configured to be coupled to a torso of the wearer, wherein the actuator is coupled to the torso brace.

US Pat. No. 10,596,056

UPPER LIMB REHABILITATION ROBOT SYSTEM

Institute of Automation C...

1. An upper limb rehabilitation robot system comprising a computer and a rehabilitation robot;wherein the computer is used for performing information interaction with the rehabilitation robot, recording training information, sending control command to the rehabilitation robot, showing the virtual training environment, providing rehabilitation training visual feedback and showing the control interface and rehabilitation training information;
wherein the rehabilitation robot, acting as a system actuator, is connected to the computer for receiving the control command from the computer to complete the motion control and terminal power output, and sending sensor data to the computer at the same time; and
wherein the rehabilitation robot includes a kinematic mechanism that is a five-bar parallel mechanism formed by four arms and two rotation axes, in order to achieve a force output in any direction of the motion in a planar workspace, and wherein a driving torque outputted by an electric actuator is magnified and transmitted to the kinematic mechanism by a cable transmission.

US Pat. No. 10,596,054

INFANT WARMING SYSTEM AND METHOD

General Electric Company,...

17. An infant warming system comprising:at least two temperature probes, each of the at least two temperature probes having:
a temperature sensor configured to measure a temperature on the infant, wherein the temperature sensor is one of a body temperature sensor removably fixable to an infant's torso to measure a body temperature of the infant and a peripheral temperature sensor removably fixable to the infant's extremity to measure a peripheral temperature of the infant;
a connector configured to connect to an input jack to transmit the temperature measurement;
at least two identical input jacks, each identical input jack configured to receive the connector of either one of the at least two temperature probes;
a probe detection module configured to automatically distinguish whether each identical input jack is connected to a body temperature probe having the body temperature sensor measuring body temperature or a peripheral temperature probe having the peripheral temperature sensor measuring a peripheral temperature; and
a temperature determination module configured to measure a temperature of at least one infant based on the probes detected by the probe detection module, wherein:
if one of the at least two temperature probes comprises the peripheral temperature sensor and the other of the at least two temperature probes comprises the body temperature sensor, then determine a temperature differential between the body temperature measurement for the infant and the peripheral temperature measurement for the infant;
if both of the at least two temperature probes comprises the body temperature sensor, then determining two body temperatures for two different infants; and
if both of the at least two temperature probes comprises the peripheral temperature sensor, generate an error alert.

US Pat. No. 10,596,053

INFLATABLE ASSIST CHAIR

1. An inflatable assist chair comprising:a chair and a compressor;
wherein the chair is inflated using the compressor to form an inflated chair;
wherein the chair is deflated using the compressor to form a deflated chair;
wherein the deflated chair is adapted to be placed under a supine person;
wherein the supine person is adapted to be elevated and repositioned into a seated position when the inflated chair is fully formed;
wherein the chair comprises a rear side, a bottom, a top, a front side, a seat back, a seat, a left side, and a right side;
wherein the chair is an airtight container that is inflated and deflated;
wherein when inflated, the chair expands and changes shape to form the inflated chair;
wherein when deflated, the chair contracts and changes shape to form the deflated chair;
wherein the rear side is a rectangular outer covering on the rear side of the inflated chair;
wherein the rear side is defined by a first edge, a second edge, a third edge, and a fourth edge;
wherein the bottom is a rectangular outer covering on the underside of the inflated chair;
wherein the bottom is defined by a fifth edge, a sixth edge, a seventh edge, and an eighth edge;
wherein the top is a rectangular outer covering on the top side of the inflated chair;
wherein the top is defined by a ninth edge, a tenth edge, an eleventh edge, and a twelfth edge;
wherein the front side is a rectangular outer covering on the underside of the inflated chair;
wherein the front side is defined by a thirteenth edge, a fourteenth edge, a fifteenth edge, and a sixteenth edge;
wherein the seat is a rectangular outer covering on the underside of the inflated chair;
wherein the seat is defined by a twenty-first edge, a twenty-second edge, a twenty-third edge, and a twenty-fourth edge;
wherein the left side is an L-shaped outer covering of the chair located on the left side of the chair;
wherein the left side is defined by a twenty-fifth edge, a twenty-sixth edge, a twenty-seventh edge, a twenty-eighth edge, a twenty-ninth edge, and a thirtieth edge;
wherein the right side is an L-shaped outer covering of the chair located on the right side of the chair;
wherein the right side is defined by a thirty-first edge, a thirty-second edge, a thirty-third edge, a thirty-fourth edge, a thirty-fifth edge, and a thirty-sixth edge.

US Pat. No. 10,596,051

SYSTEM AND METHOD FOR PATIENT TURNING AND REPOSITIONING WITH SIMULTANEOUS OFF-LOADING OF THE BODY IN THE PRONE POSITION

MOLNLYCKE HEALTH CARE AB,...

4. A system for patient turning and positioning, comprising:a plenum comprising a fixed amount of static gas therein, the plenum comprising an upper bladder having a first width configured to a shape to fit underneath a patient's back and an extension bladder having a second width that is smaller than the first width,
wherein at least a portion of the extension bladder comprises a higher coefficient of friction than at least a portion of the upper bladder.

US Pat. No. 10,596,050

MOTOR-DRIVING MECHANISM AND MOTOR-DRIVEN FURNITURE

Jiaxing Sino Hardware Man...

1. A motor-driven furniture comprising:a frame;
a motor; and
a lifting lever mounted to the frame for rotation between a lifted position in which a liftable part of the furniture is lifted and a lowered position in which the liftable part of the furniture is lowered, the lifting lever comprising a first section and a second section connected to the first section, the second section configured to support the liftable part of the furniture, the first section pivotably connected to the motor, the second section connected to the first section in such a way that the first section and the second section are fixedly connected and as a whole are drivable by the motor to rotate in a first direction from the lowered position toward the lifted position, and the first section is not fixedly connected to the second section and is drivable by the motor to rotate relative to the second section in a second direction from the lowered position toward a third position while the second section remains at the lowered position, the second direction being opposite to the first direction.

US Pat. No. 10,596,049

WHEELCHAIR PIN PLATFORM GUARD

1. A device to be used with a wheelchair having an exposed pin platform including a plate with a peg for supporting a detachable leg rest for protecting a wheelchair user comprising:a protection cover member having at least approximately the cross-sectional shape of the plate, the protection cover member comprising a partial opening configured to fit over the plate and a hole configured to receive the peg;
the protection cover member comprising a unitary piece of flexible material configured to grasp the plate and peg without assembly mating elements.

US Pat. No. 10,596,047

ELASTICATED MATERIALS WITH DIRECTIONAL STRETCH PROPERTIES

KIMBERLY-CLARK WORLDWIDE,...

1. An elasticated material comprising:a first layer of material;
a second layer of material bonded to the first layer of material by a first pair of bonds comprising a first bond and a second bond and a second pair of bonds comprising a third bond and a fourth bond; and
a plurality of elastomeric strands extending in a lateral direction and disposed between the first layer of material and the second layer of material and separated in a longitudinal direction,
wherein the first bond and the second bond are disposed on opposite sides of a first strand of the plurality of elastomeric strands and are separated by a longitudinal distance less than an un-tensioned diameter of the first strand,
wherein the third bond and the fourth bond are disposed on opposite sides of a second strand of the plurality of elastomeric strands and are separated by a longitudinal distance less than an un-tensioned diameter of the second strand,
wherein the first bond and the third bond are located on a first side of the first strand and the second strand, respectively, and the second bond and the fourth bond are located on a second side of the first strand and the second strand, respectively,
wherein the first bond and the third bond comprise first side portions and second side portions,
wherein the first side portion of the first bond forms a first angle with respect to the first strand of the plurality of elastomeric strands,
wherein the first side portion of the third bond forms a second angle with respect to the second strand of the plurality of elastomeric strands, and
wherein the first angle is different than the second angle.

US Pat. No. 10,596,046

TAMPON PLEDGET FOR INCREASED BYPASS LEAKAGE PROTECTION

Edgewell Personal Care Br...

1. A tampon pledget, comprising:a bottom pad having a length that is between about 1 inch and about 4 inches, and a width that is between about 1 inch and about 4 inches;
a top pad having a width of about 2 inches and a length of about 4 inches;
a fiber weight distribution ratio of the bottom pad to the top pad being between about 0.75:1 and about 1.5:1; and
wherein prior to folding the bottom pad and the top pad to form a compressed tampon pledget, the top pad and the bottom pad are in a cross-pad configuration, the cross-pad configuration having an overlap portion that is formed where the top pad and the bottom pad overlap and a plurality of non-overlap portions that are formed where the top pad and the bottom pad do not overlap
wherein the cross-pad configuration is folded, compressed, and heated to form a shaped tampon pledget, the tampon pledget having insertion tip region having an insertion tip end and an insertion rearward end, a main body region having a main forward end and a main rearward end, and a withdrawal region having a withdrawal forward end and withdrawal rearward end, said insertion rearward end is adjacent said main forward end, and said main rearward end is adjacent said withdrawal forward end, the shaped tampon pledget has a maximum diameter of the insertion tip region and the main body region where the insertion rearward end and the main forward end meet, wherein the main body region tapers from the maximum diameter to a minimum diameter and thereafter increases to a middle diameter that is greater than said minimum diameter, the compressed tampon pledget having a greater absorption potential near the bottom end of the tampon pledget.

US Pat. No. 10,596,045

COMPOSITE STRETCHABLE MEMBER, WEARABLE ARTICLE, AND METHOD FOR PRODUCING WEARABLE ARTICLE

ZUIKO CORPORATION, Osaka...

1. A composite stretchable member which is stretchable in a specific direction, comprising:two sheets which are opposed to each other; and
a plurality of elastic elements each disposed between the sheets to extend along the specific direction in such a manner as to be stretchable in the specific direction,
wherein:
the sheets are bonded together in a plurality of bonding sections, each of the bonding sections being configured to continuously extend along a line intersecting the specific direction and to intersect the plurality of elastic elements; and
each of the elastic elements is bonded to the sheets at intersection points with the bonding sections.

US Pat. No. 10,596,043

COLOR PRINTED LAMINATED STRUCTURE, ABSORBENT ARTICLE COMPRISING THE SAME AND PROCESS FOR MANUFACTURING THE SAME

1. A process for manufacturing a disposable absorbent article comprising a wearer-facing surface and a garment-facing surface, the method comprising the steps of:providing a first layer comprising a first surface and an opposing second surface, wherein the first layer comprises a film;
color printing the first layer on at least one of the first surface or second surface, wherein the color printing comprises more than one color;
providing a second layer comprising constituent fibers, wherein the second layer is a nonwoven and has a first surface and an opposing second surface;
providing a topsheet, an absorbent core, and a backsheet, wherein the topsheet forms a portion of the wearer-facing surface and the backsheet forms a portion of the garment-facing surface; and
placing the first layer and second layer between the topsheet and an absorbent core such that the color printing is visible through the wearer-facing surface.

US Pat. No. 10,596,041

APPARATUSES AND METHODS FOR MINIMIZING WOUND DEHISCENCE, SCAR SPREAD, AND/OR THE LIKE

ASCENSION TEXAS, Austin,...

18. A method for minimizing scar spread and reducing risk of wound dehiscence, the method comprising:adjusting a distance between a flexible first strip and a flexible second strip, the first and second strips coupled to a patient's skin on opposing sides of a sutured wound; and
coupling an inelastic and flexible layer of material across the first and second strips such that the layer is held in tension by and resists separation of the first and second strips;
where the layer is configured to substantially overlie both of the first and second strips.

US Pat. No. 10,596,040

TRANSDERMAL ADMINISTRATION DEVICE

TOPPAN PRINTING CO., LTD....

1. A transdermal administration device, comprising:a microneedle comprising a substrate, and a projection protruding from a first surface of the substrate;
a first adhesive sheet comprising a first base sheet and a first adhesive layer such that the first adhesive layer is adhered to a second surface of the substrate on an opposite side of the first surface and that the first base sheet and first adhesive layer are extending outward from the second surface of the substrate;
a second adhesive sheet comprising a second base sheet and a second adhesive layer such that the second adhesive layer is adhered to the first base sheet of the first adhesive sheet and that the second base sheet and second adhesive layer are extending outward from the first adhesive sheet; and
a cover comprising a main body configured to cover the microneedle and the first adhesive sheet, and a flange extending outward from an edge of the main body and adhered to the second adhesive layer of the second adhesive sheet,
wherein the cover is formed such that the main body and the flange form a structure body including a remaining portion which includes at least a portion of the flange and is configured to remain adhered on the second adhesive sheet, a tear-off portion which includes at least a portion of the main body and is configured to be separated from the remaining portion, and a tear-off assistance portion configured to form a cut separating the tear-off portion from the remaining portion.

US Pat. No. 10,596,039

MACHINE-READABLE MEDIUM, KERATOTOMY SYSTEM, AND KERATOTOMY METHOD

1. A corneal ablation system comprising:an operation device for collecting corneal status information that includes information of a low-order aberration of a cornea, a corneal thickness distribution map, and a posterior corneal shape map and creating an integrated corneal ablation plan for simultaneously correcting a defective shape and a curvature error of the cornea according to the corneal status information;
a laser control unit for controlling a laser module according to the integrated corneal ablation plan transmitted from the operation device; and
the laser module for generating and transmitting laser light to an optical unit under control of the laser control unit,
wherein the operation device is configured to:
create a partial corneal ablation plan for cutting the cornea on a region except for an eccentric posterior corneal cone by using the corneal thickness distribution map and the posterior corneal shape map to reduce thickness deviation from a point symmetry;
estimate curvature fluctuation that is generated upon execution of the partial corneal ablation plan to obtain a myopic spherical aberration for offsetting the curvature fluctuation;
add the myopic spherical aberration to the low-order aberration of the cornea to obtain an interlocking low-order aberration, and
create the integrated corneal ablation plan by integrating the partial corneal ablation plan with the interlocking low-order aberration.

US Pat. No. 10,596,038

CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN

JOURNEY1, INC., Brisbane...

17. A method of treating a cornea of an eye, comprising:applying an apparatus to an anterior surface of a cornea, wherein the cornea comprises an epithelium, a stroma, an inner portion and an outer portion; and
applying energy from the apparatus to denervate a region of the cornea corresponding to a
denervation treatment profile,
wherein denervation comprises denervating nerves without causing substantial damage to the endothelium.

US Pat. No. 10,596,036

DEVICE FOR TREATING GLAUCOMA

InnFocus, Inc., Miami, F...

1. An implantable device for treatment of glaucoma of the eye, the implantable device comprising:an elongate duct for diverting aqueous humor from the anterior chamber of the eye, said elongate duct having a central longitudinal axis with a proximal end and distal end opposite one another; and
first and second tabs that are spaced apart from the proximal end and the distal end of said elongate duct and extend radially outward beyond an outer surface of said elongate duct on opposite sides of said elongate duct to respective outer edges, wherein each outer edge has a first portion having a tapered profile facing the distal end of said elongate duct, and has a second portion at a maximal radial offset with respect to the central longitudinal axis, the second portion of said outer edges defining a maximal cross-sectional dimension of the device, and wherein the first and second portions of each outer edge extend longitudinally relative to the central longitudinal axis of said elongate duct;
wherein said first and second tabs each have a hardness within a range between Shore 30A and Shore 80A, and wherein said outer edges of said first and second tabs are configured to contact and form a seal with ocular tissue that surrounds said first and second tabs.

US Pat. No. 10,596,035

APPARATUS FOR TREATING EXCESS INTRAOCULAR FLUID

Ecole Polytechnique Feder...

1. A device for the treatment of excess fluid pressure within an eye, the device comprising:a housing configured to be implanted beneath a conjunctiva;
a deformable tube disposed within the housing, the deformable tube having an exterior surface and a continuous lumen extending between a first end configured for fluid communication with an anterior chamber of the eye and a second end configured to be disposed beneath the conjunctiva, the deformable tube having a variable flow area; and
a spring having a substantially constant spring force within a predetermined working range, the spring mounted within the housing to apply a force on a portion of the exterior surface of the deformable tube sufficient to self-regulate the flow of fluid through the deformable tube.

US Pat. No. 10,596,034

CRUSHING TIP FOR EYE SURGERY

1. A crushing tip for an eye surgery, which is adapted to be inserted into a crystalline lens of an eye of a patient at a time of an eye surgery for crushing, sucking, and discharging the crystalline lens by providing ultrasonic vibrations, comprising:a cylindrical tip main member having a tip end face at one end, and a through hole; and
a partition wall having one end and provided in the through hole to cross therethrough,
wherein the one end of the partition wall is positioned on a same face as the tip end face at the one end of the tip main member.

US Pat. No. 10,596,033

PHACOEMULSIFICATION ULTRASONIC DEVICE SWITCHING BETWEEN DIFFERENT OPERATIONAL MODES

1. A surgical instrument for a phacoemulsification procedure, the surgical instrument comprising:a handpiece that includes a piezoelectric transducer;
a hollow titanium needle having a free distal tip and a supported end structure that is attached to the handpiece, the supported end structure includes external threads that mate with internal threads in the handpiece, the hollow titanium needle having a substantially cylindrical portion between the supported end structure and the free distal tip;
a circuit that drives the piezoelectric transducer to a) periodically expand and contract at a high-ultrasound frequency that rings the hollow titanium needle with a high-ultrasonic frequency standing wave consisting of a single node of minimum amplitude residing in the substantially cylindrical portion between the supported end structure and the free distal tip, and b) periodically expand and contract at an ultrasound frequency that rings the hollow titanium needle with an ultrasonic frequency standing wave, the circuit configured to switch the piezoelectric transducer from between the high-ultrasonic frequency and the ultrasonic frequency, but not both a) and b) at the same time.

US Pat. No. 10,596,032

SYSTEM AND METHOD FOR CONTROLLING A TRANSVERSE PHACOEMULSIFICATION SYSTEM WITH A FOOTPEDAL

1. An apparatus configured for use in an ocular surgical procedure, comprising: a handpiece having a tip configured to ultrasonically vibrate, the handpiece configured to support a plurality of operating modes comprising a first operating mode and a second operating mode, wherein at least one tip displacement parameter is allocated to the first operating mode and at least one tip displacement parameter is allocated to the second operating mode; an engageable switching apparatus; and a controller connected to the handpiece and the engageable switching apparatus, wherein the engageable switching apparatus comprises a footpedal and is capable of deflection, and wherein the controller is configured to: receive input from the engageable switching apparatus, generate a tip displacement control signal to vary a tip displacement ratio of the handpiece based on the input received from the engageable switching apparatus, and transmit the tip displacement control signal to the handpiece, thereby enabling a user to dynamically adjust the tip displacement ratio, wherein the tip displacement ratio relates the at least one tip displacement parameter allocated to the first operating mode to the at least one tip displacement parameter allocated to the second operating mode, and wherein dynamically adjusting the tip displacement ratio includes adjusting a percentage of the at least one tip displacement parameter allocated to the first operating mode and adjusting a percentage of the at least one tip displacement parameter allocated to the second operating mode in real-time based on input received from the engageable switching apparatus, wherein the adjusting of the percentages of the at least one tip displacement parameters of the first operating mode and the second operating mode is relative to each other, and wherein the adjusting of the percentages is based on an amount of the deflection of the engageable switching apparatus, wherein adjusting the tip displacement ratio comprises 1) increasing the at least one tip displacement parameter allocated to the first operating mode while proportionally decreasing the at least one displacement parameter allocated to the second operating mode, or 2) decreasing the at least one tip displacement parameter allocated to the first operating mode while proportionally increasing the at least one displacement parameter allocated to the second operating mode.

US Pat. No. 10,596,027

APPARATUS FOR IMPROVED BREATHING

AirWay Technologies, LLC,...

1. An oral appliance comprising:a lower frame configured to be positioned within a user's mouth, the lower frame comprising:
a left occlusal portion configured to be positioned proximate at least one of a left bicuspid or a left molar of a mandibular arch of the user but not proximate an incisor of the mandibular arch of the user;
a right occlusal portion configured to be positioned proximate at least one of a right bicuspid or a right molar of the mandibular arch of the user, wherein the left and right occlusal portions define an open space between the left occlusal portion and the right occlusal portion, the space configured to be positioned above the incisor of the mandibular arch of the user when the lower frame is positioned within the user's mouth; and
a flange coupled to the left occlusal portion and the right occlusal portion, the flange extending substantially perpendicular and mesial to the left and right occlusal portions;
a thermoplastic moldable tray coupled to the left occlusal portion, the right occlusal portion, and the flange such that the thermoplastic moldable tray extends beyond the flange in an inferior direction, the thermoplastic moldable tray comprising irradiated, cross-linked thermoplastic polymer not customized to any user's teeth, wherein the irradiated, cross-linked thermoplastic polymer softens to be moldable to a shape of a portion of the user's dental arch when the thermoplastic polymer is heated to 40 to 80 degrees Celsius; and
an adjustment mechanism coupled to the lower frame, the adjustment mechanism configured to adjust a forward position of the lower frame relative to an upper frame configured to be positioned proximate a maxillary arch of the user.

US Pat. No. 10,596,026

APPARATUS FOR IMPROVED BREATHING

AirWay Technologies, LLC,...

1. An oral appliance comprising:a frame configured to be positioned within a user's mouth, the frame comprising:
an occlusal surface configured to be positioned proximate an occlusal surface of a dental arch of the user, the occlusal surface of the frame comprising:
a first occlusal portion configured to be positioned proximate at least one of a left bicuspid and a left molar of the dental arch of the user; and
a second occlusal portion configured to be positioned proximate at least one of a right bicuspid and a right molar of the dental arch of the user;
wherein the occlusal surface of the frame defines an open space that extends between the first occlusal portion and the second occlusal portion, the open space configured to be positioned proximate an incisor of the dental arch when the frame is positioned in the user's mouth; and
a thermoplastic moldable tray comprising irradiated, cross-linked thermoplastic polymer not customized to any user's teeth, wherein the irradiated, cross-linked thermoplastic polymer softens to be moldable to a shape of a portion of the user's dental arch when the thermoplastic polymer is heated to 40 to 80 degrees Celsius;
wherein the thermoplastic moldable tray is coupled to the first and second occlusal portions such that the frame does not extend beyond the thermoplastic moldable tray in a buccal direction and such that the tray is substantially between the frame and the dental arch of the user when the frame is positioned in the user's mouth.

US Pat. No. 10,596,020

CATHETER DEVICE

17. A catheter having a shaft and an implant mounted on a distal end of the shaft wherein the shaft comprises:an adapter block comprising a first shaft lumen and a second shaft lumen;
a first shaft element having a distal end within the first shaft lumen and a proximal end disposed at a handle;
a second shaft element having a proximal end within the second shaft lumen;
a sheath that lies over the implant having a proximal end distal of the adapter block;
an annulus disposed outside the second shaft element, disposed inside the sheath, and extending proximally of the proximal end of the sheath;
a pull wire disposed in the first shaft element and connected to the annulus;
a telescopic tube having a distal end connected to the proximal end of the sheath;
a flushing tube connected to a proximal end of the telescopic tube;
a guider block comprising a guider block lumen and a guider block guidewire lumen; and
a band disposed around the flushing tube connecting the flushing tube to the guider block, wherein:
a distal bend of the second shaft element is proximal of the annulus,
a proximal bend of the second shaft element is distal of the adapter block, and
the guider block is disposed on the first shaft element.

US Pat. No. 10,596,019

LOADING APPARATUS AND SYSTEM FOR EXPANDABLE INTRALUMINAL MEDICAL DEVICES

Cook Medical Technologies...

1. A medical device loading system, comprising:a loading apparatus comprising a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings, the passageway defining a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers, the second inner diameter being greater than the first inner diameter and the transition chamber having an inner diameter that transitions along an axial length of the transition chamber from the second inner diameter to the first inner diameter;
a delivery catheter comprising an outer tubular member defining a sheath lumen, a dilator body disposed within the sheath lumen and defining a dilator lumen, and a distal tip member comprising an elongate cannula and a distal tip body, the elongate cannula adapted to be slideably disposed within the dilator lumen and the distal tip body defining an outer diameter that is smaller than the second inner diameter and larger than the first inner diameter; and
an expandable intraluminal medical device;
wherein the distal tip member has a separable connection that divides the distal tip member into a proximal distal tip member portion and a distal distal tip member portion when disrupted.

US Pat. No. 10,596,018

INTRAVASCULAR STENT

Abbott Cardiovascular Sys...

1. A flexible intravascular stent for use in a body lumen, comprising:a plurality of cylindrical rings aligned along a common longitudinal axis;
an undulating link connecting adjacent cylindrical rings together, the undulating link having a curved portion connecting two straight portions, the two straight portions being transverse to a longitudinal axis of the stent;
wherein each cylindrical ring includes a plurality of peaks and a plurality of valleys, the plurality of peaks including a first peak having a first height and a first radius of curvature, a second peak having a second height and a second radius of curvature, the second height being less than the first height and the second radius of curvature being greater than the first radius of curvature, and a third peak having a third height and a third radius of curvature, the third height being less than the second height and the third radius of curvature being greater than the second radius of curvature;
wherein a first end of the undulating link is connected only to the third peak on one cylindrical ring and a second end of the undulating link is connected only to an intermediate valley on an adjacent cylindrical ring; and
wherein the curved portion of the undulating link is axially aligned with but not overlapping a second peak of the cylindrical ring connected to the first end of the undulating link when the stent is in a compressed configuration.

US Pat. No. 10,596,017

SELF-SEALING TUBULAR GRAFTS, PATCHES, AND METHODS FOR MAKING AND USING THEM

SOLINAS MEDICAL INC., Sa...

1. A self-sealing cuff, comprising:base material defining a first end, a second end, and having a “C” shaped cross-section defining opposing edges extending between the first and second ends; and
first and second reinforcement members embedded within the base material, the first reinforcement member extending axially along a first length and including elements that extend at least partially around a circumference of the base material, the second reinforcement member extending axially along the first length and including elements that extend at least partially around the circumference of the base material, the second reinforcement member disposed concentrically around and spaced apart radially from the first reinforcement member along the first length; and wherein base material is located between the radially spaced apart first and second reinforcement members.

US Pat. No. 10,596,015

INTRALUMINAL VASCULAR PROSTHESIS

JOTEC GmbH, Hechingen (D...

1. An intraluminal vascular prosthesis designed for implantation in the area of the ascending aorta, the aortic arch and the descending aorta in a patient in need thereof, wherein the vascular prosthesis for introduction into the aorta can be transferred from a compressed state to an expanded state, the vascular prosthesis having a hollow cylindrical body with a first end and a second end,wherein the vascular prosthesis comprises, at its first end, a first vascular prosthesis portion, with successive rings of meandering supports, and a first prosthesis material secured onto the rings and connecting them,wherein the vascular prosthesis has, at its second end, a second vascular prosthesis portion consisting exclusively of a second prosthesis material and not having successive rings of meandering supports connected to the second prosthesis material,wherein the vascular prosthesis moreover has a tubular stent portion which is provided between the first vascular prosthesis portion and the second vascular prosthesis portion and which is fixedly connected to said vascular prosthesis portions, said tubular stent portion being substantially free of any prosthesis material and consisting of a self-expanding stent material and having meshes or openings, wherein the second prosthesis material of the second vascular prosthesis portion overlaps with the tubular stent portion, such that the tubular stent portion is only covered in the connecting area with the second vascular prosthesis portion and otherwise remains free from prosthesis material,
and wherein the stent portion is designed for a release in the area of the aortic arc in the area of the origins of the brachiocephalic trunk, the common carotid artery and the left subclavian artery, such, that the stent portion allows blood to flow into the branching-off vessels of the brachiocephalic trunk, the common carotid artery and the left subclavian artery, and wherein the first vascular prosthesis portion for a release in the distal direction in relation to the subclavian artery, and the second vascular prosthesis portion for a release in the proximal direction in relation to the origin of the brachiocephalic trunk.

US Pat. No. 10,596,013

WALKING ASSISTANCE APPARATUS AND METHOD OF CONTROLLING THE WALKING ASSISTANCE APPARATUS

Samsung Electronics Co., ...

1. A method of controlling a walking assistance apparatus, the method comprising:measuring, using a sensor of the walking assistance apparatus, a movement of a hip joint of a user associated with the walking assistance apparatus and a movement associated with another portion of a body of the user;
correcting movement information of the hip joint based on movement information of the other portion of the body to generate corrected movement information; and
controlling a torque to apply to a driver of the walking assistance apparatus based on the corrected movement information of the hip joint, wherein
the driver is configured to assist the user in walking.

US Pat. No. 10,596,012

ARTIFICIAL LIMB FOR HOST ASSISTANCE

Toyota Research Institute...

1. A mobility system for improving mobility of a user, comprising:a support component including at least a waist device that is configured to secure the mobility system to the user at a waist area of the user; and
a single limb attached to the support component and extendable from the support component to a floor when the user is in a standing position, wherein the single limb is configured to support the user by providing a rigid structure between the floor and the user and in isolation without additional support structures,
wherein the single limb is configured to assist the user in transitioning from a seated position to the standing position by applying a substantially upward force to the user through the support component when transitioning to the standing position,
wherein the support component is configured to attach the single limb midway on a back of the user aligned with a spine of the user, and
wherein the single limb is configured to be wholly aligned with the spine of the user.

US Pat. No. 10,596,011

ORTHOPAEDIC SURGICAL INSTRUMENT AND METHOD FOR POSITIONING AN ACETABULAR PROSTHETIC COMPONENT

DePuy Ireland Unlimited C...

1. An orthopaedic surgical instrument, comprising:a first impactor head having a convex curved impaction surface configured to engage a concave curved surface of an acetabular cup prosthesis,
a second impactor head having a concave curved impaction surface configured to engage a convex curved surface of a femoral head prosthesis, and
a suction cup configured to be selectively coupled to the first impactor head and the second impactor head, the suction cup including a distal opening that is defined by an outer rim positioned proximal of the impaction surface of the first impactor head or the second impactor head when one of the impactor heads is coupled to the suction cup,
wherein the suction cup is configured to engage both the concave curved surface of the acetabular cup prosthesis and the convex curved surface of the femoral head prosthesis so as to selectively couple the first impactor head to the to the acetabular cup prosthesis and the second impactor head to the femoral head prosthesis.

US Pat. No. 10,596,010

STAND-ALONE EXPANDABLE INTERBODY SPINAL FUSION DEVICE WITH LOCKING MECHANISM

1. A stand-alone expandable interbody spinal fusion device, comprising:a superior component;
an inferior component;
an expansion mechanism operatively arranged to displace the superior component in a first direction relative to the inferior component about a first hinge; and,
a locking mechanism comprising:
a plate operatively arranged to pivot about a second hinge, the plate further comprising a first aperture and a first plurality of teeth;
a pawl operatively arranged to pivot about a third hinge, the pawl further comprising a second aperture; and,
a post operatively arranged to pass through the first and second apertures,
wherein after the superior component is displaced in the first direction, the locking mechanism prevents displacement of the superior component in a second direction, opposite the first direction.

US Pat. No. 10,596,009

KNEE AUGMENT

1. A knee prosthesis kit, comprising:an implant including an implant base and a stem extending from the implant base, the implant base having a superior side and an inferior surface, and further including at least one planar wing extending from the stem and the inferior surface; and
an augment including an augment base, the augment base having an implant surface and a bone contacting surface, the augment also including a cone-shaped portion extending distally from the augment base in a direction away from the bone contacting surface to a distal end of the cone-shaped portion, the cone-shaped portion having a cone-shaped outer surface, the augment base having at least two openings for receiving fasteners for securing the augment to the implant base, the cone-shaped portion and the augment base comprising a bore for receipt of the implant stem, the cone-shaped portion comprising at least two grooves extending distally from the augment base parallel to a direction of fastener insertion, wherein the at least two grooves are aligned with the at least two openings to provide clearance for the fasteners;
wherein the inferior surface of the implant base is adapted to receive the implant surface of the augment, and the implant surface is engaged with the inferior surface when the augment is secured to the implant base; and
wherein the augment further comprises a clearance space with a first portion in the augment base and a second portion in the cone-shaped portion, the first and second portions arranged to receive the at least one planar wing.

US Pat. No. 10,596,008

METHOD OF DESIGNING ORTHOPEDIC IMPLANTS USING IN VIVO

1. A reconfigurable orthopedic implant system comprising:a tibial tray insert trial including a right bay and a left bay, each bay configured for receiving a condyle receiver insert for reconfiguring the tibial tray insert trial;
a plurality of condyle receiver inserts configured for being removably mounted in a respective one of the bays, the condyle receiver inserts varying in shape with respect to each other for reconfiguring the tibial tray insert trial;
a plurality of orifices formed in the tibial tray insert trial generally at a plurality of different locations between the right and left bays, each of the orifices configured for receiving a tibial post for further reconfiguring the tibial tray insert trial;
a plurality of tibial posts, each post being configured for insertion into an orifice, each of the of tibial posts varying in shape with respect to each other for configuring the tibial tray insert trial;
a tibial tray configured for receiving the tibial tray insert trial.

US Pat. No. 10,596,007

EXTRA-ARTICULAR IMPLANTABLE MECHANICAL ENERGY ABSORBING SYSTEMS AND IMPLANTATION METHOD

MOXIMED, INC., Fremont, ...

1. An implantable device for relieving knee joint pain while a patient is ambulating, the device comprising:a first base and a second base each configured for attachment to bones on opposite sides of a patient's knee joint; and
an energy manipulation assembly comprising:
a spring;
a rod;
a mating section engaged to the first base;
a first joint positioned between and connected to the mating section and one of the rod and the spring; and
a second joint positioned between the other of the rod and the spring and the second base,
wherein the rod is configured to compress the spring and transfer load between the first base and the second base when the first base and the second base are a first distance apart while a patient is ambulating, and the rod is configured to move relative to the spring while a patient is ambulating such that the energy manipulation assembly transfers no force between the first base and the second base beyond a point where the first base and the second base are a second distance apart, wherein the second distance is larger than the first distance.

US Pat. No. 10,596,006

ELBOW PROSTHESIS

Encore Medical, L.P., Au...

1. An elbow prosthesis comprising:a tray structure operable to be positioned in a bone of a joint, the tray structure comprising:
a first C-shaped body portion having a first retaining mechanism formed thereon;
a boss portion extending from the first C-shaped body portion and defining a bore extending a first distance and operable to be positioned in the bone;
an articulating component having a second retaining mechanism formed thereon the articulating component comprising:
a second C-shaped body portion extending between a first end and a second end; and
a tab extending from the first end, the tab including a passage extending through the tab for receiving a fastener therethrough;
a securing member having a length that is greater than the first distance, the securing member adapted to be inserted into the boss, such that a portion of a distal end of the securing member is advanced into the bone in an implanted position; and
wherein the first and second retaining mechanisms cooperatively mate to inhibit movement of the articulating component relative to the first C-shaped body portion in an assembled position.

US Pat. No. 10,596,005

FRICTIONLESS HIP JOINT

1. An orthopedic hip prosthesis comprising:a prosthetic femoral neck sized and configured to be fixedly connected to a femur of a patient, the prosthetic femoral neck comprising a cylindrical axle extending from a proximal end and a femoral shank extending from a distal end, the axle defining an outer circumferential surface and a reservoir disposed within the axle;
a prosthetic femoral head sized and configured to be received by an acetabulum of the patient and rotationally connected to the prosthetic femoral neck, the prosthetic femoral head being substantially spherical and comprising a cylindrical recess defining an inner circumferential surface, wherein the axle of the prosthetic femoral neck is rotationally engaged within the recess of the prosthetic femoral head;
a plurality of roller bearings proximally-positioned between the outer circumferential surface of the axle and the inner circumferential surface of the recess, the plurality of roller bearings disposed to support rotational movement between the prosthetic femoral head and the prosthetic femoral neck; and
a plurality of ball bearings positioned between the outer circumferential surface of the axle and the inner circumferential surface of the recess, the plurality of ball bearings disposed to restrict translational movement of the prosthetic femoral neck relative to the prosthetic femoral head, the plurality of ball bearings retained inside an annular retention channel,
wherein said prosthetic femoral head and said prosthetic femoral neck are configured to accommodate coaxial motion of the hip joint.

US Pat. No. 10,596,003

SACROILIAC JOINT IMPLANT SYSTEM

JCBD, LLC, Fort Collins,...

1. A method of treating a sacroiliac joint at a sacroiliac joint region having a sacrum, an ilium and a sacroiliac joint space therebetween, the ilium comprising a posterior inferior iliac spine (PIIS) and a posterior superior iliac spine (PSIS), the method comprising:delivering a joint implant into the sacroiliac joint region via a posterior approach such that the joint implant passes through a posterior access region defined between the PSIS and the PIIS, the joint implant being oriented in the sacroiliac joint space such that a portion of the joint implant is positioned within a joint plane of the sacroiliac joint space, the joint implant comprising a body including a length extending between a proximal end and the distal end, an external surface extending the length, and a fixation member receiving channel extending the length and disposed in the external surface; and
delivering a fixation member into the fixation member receiving channel such that the fixation member passes through the posterior access region defined between the PSIS and the PIIS thereby forming a joint implant assembly, the fixation member slidingly and matingly engaging the fixation member receiving channel in a grooved arrangement, wherein, when the fixation member is received into the fixation member receiving channel, the fixation member extends outward from the external surface of the joint implant and extends a portion of the length.

US Pat. No. 10,596,002

SACROILIAC FUSION SYSTEM

RTI Surgical, Inc., Alac...

1. A method of performing a sacroiliac fusion procedure, wherein the method comprises:providing a cutting assembly having a distal end;
forming an aperture in an ilium;
positioning the cutting assembly in a retracted configuration;
extending the distal end of the cutting assembly through the aperture in the ilium;
moving the cutting assembly to an extended configuration where the distal end pivots with respect to a non-pivoted portion of the cutting assembly;
rotating the cutting assembly to cut tissue between the ilium and the sacrum;
withdrawing the cutting assembly from the aperture in the ilium; and
inserting a fastening device through the aperture in the ilium and into the sacrum.

US Pat. No. 10,596,001

SYSTEM AND METHOD OF ATTACHING SOFT TISSUE TO AN IMPLANT

PURDUE RESEARCH FOUNDATIO...

1. A method of inducing the growth of fibrocartilage tissue and/or bone on an implant to enhance the attachment of the implant to a patient's tissue or bone, said method comprising:providing an implant comprising a metallic surface;
anodizing said metallic surface in the presence of an acid, thereby forming nanosurface roughness on the metallic surface; and
implanting the implant comprising the anodized metallic surface having nanosurface roughness produced from said anodizing, to induce the growth of fibrocartilage tissue and/or bone on said implant,
wherein said nanosurface roughness comprises a plurality of surface structures having an average height of about 20 nm to about 200 nm, and
wherein the distance between said surface structures ranges from about 25 nm to about 500 nm.

US Pat. No. 10,596,000

DYNAMIC BIOACTIVE NANOFIBER SCAFFOLDING

MO-SCI CORPORATION, Roll...

1. A biologically resorbable tissue regrowth scaffold material, consisting essentially of:a porous, pliable and formable support matrix comprising a plurality of overlapping and entangled solid, polymer-free bioactive, resorbable ceramic fibers;
a plurality of pores distributed throughout the support matrix; and
a plurality of bioactive, resorbable, glass or ceramic beads distributed throughout the support matrix;
wherein each respective fiber has a diameter ranging from 5 nanometers to 100 micrometers, and wherein the biologically resorbable tissue regrowth scaffold material is polymer-free.

US Pat. No. 10,595,997

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair device for repairing a native valve of a patient, the valve repair device comprising:a pair of paddles that are movable between an open position and a closed position; and
a pair of gripping members that each have a barbed portion for securing the gripping member to the native valve of the patient;
wherein each gripping member of the pair of gripping members is slidably attached to a corresponding paddle of the pair of paddles;
wherein each gripping member is moved in a first direction along the paddle before the barbed portion of the gripping member pierces the native valve of the patient; and
wherein each gripping member is moved in a direction along the paddle substantially opposite the first direction after the barbed portion pierces the native valve of the patient such that the gripping members create a tensioning force on the native valve of the patient.

US Pat. No. 10,595,996

THROMBUS MANAGEMENT AND STRUCTURAL COMPLIANCE FEATURES FOR PROSTHETIC HEART VALVES

Tendyne Holdings, Inc., ...

1. A prosthetic heart valve comprising:an outer frame assembly having an atrium portion, a ventricle portion, and an annulus portion between the atrium portion and the ventricle portion,
the outer frame assembly having an hourglass shape and including shape memory material such that the outer frame assembly reverts to a memory shape in the absence of applied forces; and
an inner valve assembly including an inner frame having an atrium end and a ventricle end,
the inner valve assembly coupled to the outer frame assembly by a connection between the ventricle end of the inner frame and the ventricle portion of the outer frame assembly,
the inner frame assembly extending from the connection towards the atrium portion of the outer frame assembly,
the inner frame assembly and the outer frame assembly diverging from each other in a direction from the connection towards the atrium portion of the outer frame assembly,
the annulus portion of the outer frame assembly being spaced radially from the inner valve assembly and radially inwardly deflectable towards the inner valve assembly to accommodate in the annulus portion a natural valve annulus having a perimeter smaller than a minimum perimeter of the annulus portion when the outer frame assembly has the memory shape.

US Pat. No. 10,595,995

DEVICE AND METHOD FOR IMPROVING FUNCTION OF HEART VALVE

Medtentia International L...

1. A method of implanting an annuloplasty device, the method comprising:directing an annuloplasty device to a native heart valve; the annuloplasty device comprising a first and second loop-shaped support, the first loop-shaped support being continuous with the second loop-shaped support to form a coil-shaped body,
inserting an end of the second loop-shaped support through a natural opening of the native heart valve formed between leaflets of the native heart valve at a commissure of the leaflets of the native heart valve,
rotating the second loop-shaped support into place on a second side of the native heart valve, opposite a first side of the native heart valve such that the second loop-shaped support abuts the second side,
placing the first loop-shaped support to abut the first side to trap a portion of the native heart valve between the first and second loop-shaped supports;
fixating a heart valve prosthesis to the annuloplasty device, and
anchoring at least one of said first and second loop-shaped supports into tissue at the native heart valve for said implanting of the annuloplasty device.

US Pat. No. 10,595,993

METHOD OF MAKING AN INTRODUCER SHEATH WITH AN INNER LINER

Edwards Lifesciences Corp...

1. A method of making an introducer sheath with an inner liner for percutaneous insertion of a medical device into a patient, comprising:inserting a metal sleeve into a mold;
inserting a polymer tube comprising a closed end and an open end into the metal sleeve;
pressurizing and heating the polymer tube to cause the polymer tube to expand against an inner surface of the metal sleeve so as to form the inner liner of the sheath.

US Pat. No. 10,595,992

DEVICES, SYSTEMS AND METHODS FOR CARDIAC TREATMENT

4C Medical Technologies, ...

1. A device for implantation within a heart chamber with a size and shape defined by at least a roof and walls and having a size and shape, the chamber in operational communication with a native valve having leaflets and an annulus, the device comprising:a retention body comprising an expandable and collapsible stent defining an interior, a first side and a second side and comprising:
a base section having an outer surface and an inner surface, wherein the outer surface of the base section comprises a lowermost surface of the device;
an opening disposed at the first side of the retention body;
at least one support member attached to the second side of the retention body opposite the first side;
an upper support member top attached to the at least one support member that, when implanted, is in contact with the roof of the chamber, the at least one support member biased to press the upper support member top against the heart chamber roof; and
a prosthetic valve comprising a plurality of prosthetic leaflets, wherein the prosthetic valve is disposed entirely within the interior of the base section and proximate the opening disposed at the first side of the retention body such that the prosthetic valve is spaced above the lowermost surface of the device,
wherein the device, when implanted in the heart chamber, is configured to be retained completely within the heart chamber and wherein the prosthetic valve is spaced away from the native valve.

US Pat. No. 10,595,991

HEART VALVE ASSEMBLIES

MEDTRONIC, INC., Minneap...

1. A prosthetic valve assembly comprising:a first annular prosthesis having a frame configured to have a first diameter in a collapsed state for introduction into a body lumen and a second diameter in an expanded state for implantation within an annulus of a heart, the first annular prosthesis having a first alignment element, wherein the first alignment element is a groove that extends in parallel with a longitudinal axis of the first annular prosthesis; and
a second annular prosthesis including a prosthetic valve, the second annular prosthesis having a second alignment element that is configured to align with the first alignment element when the second annular prosthesis is positioned within the first annular prosthesis in the expanded state.

US Pat. No. 10,595,990

OSSEOINTEGRATIVE ADJUSTABLE OSSICULAR PROSTHESIS

Gyrus ACMI, Inc., Southb...

15. An otologic prosthesis, comprising:a set of crimping prongs positioned at a distal end of the otologic prosthesis, the set of crimping prongs being joined at a proximal end thereof and open at a distal end thereof;
a lattice structure provided on a surface of each crimping prong in the set of crimping prongs; and
a stem connecting the set of crimping prongs to a TM plate at a proximal end, the stem comprising an annular snap-fit mechanism and a slit formed along a proximal portion of the stem, the TM plate comprising a plug,
wherein the plug is configured to be inserted into the annular snap-fit mechanism to secure the stem to the TM plate,
wherein the stem is configured to be cut for sizing.

US Pat. No. 10,595,988

COSMETIC CORNEAL INLAY AND IMPLANTATION METHOD THEREOF

OPHTA INNOVATIONS INC., ...

1. An intrastromal corneal insert constituted by a film of solid, transparent, impermeable, biocompatible, physiologically inert and chemically resistant material, having thickness between 4.5 and 50 ?m, wherein the intrastromal corneal insert has a shape of an annulus of variable dimensions as a function of dimensions of a cornea in a subject who has to receive the insert and of pupillometry detected in mesopic conditions in the subject, wherein a central hole of the annulus has an inner perimeter in a form of a multilobed line, wherein each lobe has a shape of an arc of circumference and the lobes are two by two symmetric and opposing, and the annulus having four holes respectively positioned at 2, 4, 8, and 10 o'clock, wherein the insert has a plurality of chromatic patterns printed thereon, and wherein the patterns reproduce a chromatic pattern of an iris in the subject who has to receive the insert or of another chromatic pattern.

US Pat. No. 10,595,987

PROSTHETIC IRIS PREPARATION METHOD

8. A method of producing an iris that matches an iris of a natural eye and gives the produced iris a lifelike appearance of a pupil that dilates in dimmed light, comprising:comparing an array of sample irises with the iris of the natural eye, wherein each sample iris in the array comprises at least one unique characteristic and a unique indicia associated with the at least one unique characteristic;
selecting one sample iris from the array of the sample irises as a matching iris;
identifying the unique indicia of the matching iris;
retrieving a digital image of the matching iris from a database in a computer based on the identified unique indicia;
using a 2-dimensional digital printer and the retrieved digital image to print the matching iris;
printing an overlay screen of closely spaced marks of a selected color with the 2-dimensional digital printer in at least a portion of a pupil region of the matching iris during the printing of the matching iris; and
encapsulating the printed matching iris in a final iris such that the final iris comprises:
i. a final cornea,
ii. the printed matching iris, and
iii. a final backing.

US Pat. No. 10,595,985

MINIMALLY INVASIVE BREAST LIFT METHOD WITH A SUPERIOR TISSUE SUPPORT AND AN INFERIOR ANCHOR

Sinclair Pharmaceuticals ...

1. A system for performing a breast tissue lift, comprising:an elongate, flexible mesh sling having a first end and a second end and configured to be subcutaneously introduced along a generally medial-lateral axis of a patient's body, wherein medial generally refers to a direction closer to the midline of the patient's body with respect to a lateral location;
a first suspension line carrying a first inferior soft tissue anchor and having a first superior free end, wherein superior generally refers to a direction that is relatively cephalad or towards the patient's head while inferior refers to a direction that is relatively caudal or towards the patient's feet;
a second suspension line carrying a second inferior soft tissue anchor and having a second superior free end, wherein each of the first and second inferior soft tissue anchors comprises a rod comprising a rounded end, an oblique end cut at an angle, and a central aperture; and
a needle for introducing the elongate, flexible mesh sling subcutaneously, the needle comprising an arc of greater than 180 degrees,
wherein the first superior free end is configured to be connected to the first end of the elongate, flexible mesh sling,
wherein the second superior free end is configured to be connected to the second end of the elongate, flexible mesh sling, and
wherein the elongate, flexible mesh sling is configured to be positioned superiorly to tissue to be lifted.

US Pat. No. 10,595,984

IMPLANTED PASSIVE ENGINEERED MECHANISMS AND METHODS FOR THEIR USE AND MANUFACTURE

Oregon State University, ...

1. An implantable passive engineered mechanism comprising a biocompatible material, the mechanism comprising a strut having a first end and a second end, the strut having an aperture on the first end to receive a suture for coupling the first end to a first output tendon and an aperture on the second end to receive a suture for coupling the second end to a second output tendon.

US Pat. No. 10,595,983

CONSTRUCTS AND METHODS FOR REPAIRING A TENDON WITH A REDUCED RISK OF REINJURY

Riverpoint Medical, LLC, ...

1. A method of effecting a tendon repair in a patient, comprising,(a) providing a suture, having:
(i) a braid of high strength fibers and fibers of absorbable polymer selected from a group consisting of poly butylene succinate homopolmers and copolymers;
(ii) including at least 2 fibers of said absorbable polymer and 4 high strength fibers;
(iii) capable of being stretched at least 10% from its shortest length to the length at which said suture breaks; and
(iv) capable of withstanding a load of at least 100 Newtons, before breaking;
(b) using said suture tape to connect tendon tissue of said patient to other tissue of said patient; and
(c) permitting ingrowth of tendon tissue into said suture tape, as said fibers of absorbable polymer are absorbed into said patient's tissue over a period of at least 11 months.

US Pat. No. 10,595,982

ENDOLUMINAL PROSTHESIS

Cook Medical Technologies...

1. An endoluminal prosthesis comprising:a tubular main body comprising a proximal end opening, a distal end opening, a main lumen extending between the proximal end opening and the distal end opening, a sidewall, a first fenestration in the sidewall, and a second fenestration in the sidewall positioned distal of the first fenestration; and
a tubular auxiliary body disposed about the main body and comprising a sidewall, an outlet opening in the sidewall, a first end attached to the main body proximal of the first fenestration, a second end attached to the main body distal of the second fenestration, and a first dividing wall attached to the sidewall of the main body and the sidewall of the auxiliary body and extending longitudinally at least partially between the first end of the auxiliary body and the second end of the auxiliary body;
wherein a cavity is disposed between the sidewall of the main body and the sidewall of the auxiliary body and comprises a first chamber and a second chamber disposed on opposite sides of the first dividing wall and in fluid communication with one another through an opening in the first dividing wall, the main lumen is in fluid communication with the first chamber through the first fenestration, the main lumen is in fluid communication with the second chamber through the second fenestration, and the first chamber is in fluid communication with a point external of the prosthesis through the outlet opening of the auxiliary body.

US Pat. No. 10,595,980

TEMPORARY VALVE AND VALVE-FILTER

Valve Medical Ltd., Tel ...

1. A percutaneous temporary valve system for use in percutaneous cardiovascular procedures, comprising a temporary valve having a central core, and a sheath for containing and delivering said temporary valve and said central core; said temporary valve comprising a valve body and a plurality of lines, each line of said plurality of lines connected at a first end to a rim of said valve body and at a second end to said central core; said central core having an inverted delivery configuration and connected to said sheath.

US Pat. No. 10,595,979

TEXTURED SURFACES FOR BREAST IMPLANTS

Establishment Labs S.A., ...

1. An implant comprising a textured surface having:at an area scale of 1 mm×1 mm:
a mean surface roughness Sa value of from 2 ?m to 12 ?m; and
a maximum peak height to trough depth Sz value of 20 ?m to 60 ?m; and
at an area scale of 90 ?m×90 ?m:
a mean surface roughness Sa value of from 0.1 ?m to 5 ?m;
wherein the surface comprises a biocompatible polymer.

US Pat. No. 10,595,978

SYSTEM AND METHOD OF LAPAROSCOPIC USE OF HEMOSTATIC PATCH

Covidien LP, Mansfield, ...

1. An apparatus for delivering a surgical patch into a body cavity during laparoscopic surgery, the apparatus comprising:a surgical patch including a first hydrogel precursor and a second hydrogel precursor on the first hydrogel precursor, the first hydrogel precursor including one of nucleophilic functional groups or electrophilic functional groups, and the second hydrogel precursor including the other of the nucleophilic functional groups or the electrophilic functional groups, the first and second hydrogel precursors configured to react with one another to form a biocompatible cross-linked material; and
a polymeric bag,
the surgical patch disposed in the polymeric bag, the surgical patch and polymeric bag configured to be received within a deployment device for delivering the surgical patch and the polymeric bag into a body cavity.

US Pat. No. 10,595,974

FLASHLIGHT DEVICE FOR CURING LIGHT-CURABLE MATERIALS, METHOD AND SET

1. A set for at least one of gluing, bonding, modeling and repairing of an object, the set comprising:a pen-type housing comprising a first end, a second end, and a reservoir;
a light-curable material arranged in the reservoir; and
an LED lamp configured to emit a light having a wavelength or a spectrum of wavelengths at which the light-curable material is selectively cured and to be coupled to the pen-type housing at the second end so that the light emitted by the LED lamp is only emitted in a direction which faces away from the first end,
wherein,
the reservoir comprises an exit opening which is configured to selectively discharge the light-curable material at the first end.

US Pat. No. 10,595,973

METHOD FOR DETERMINING RELATIVE ARRANGEMENT OF PATIENT'S JAWS

1. A method for determining a relative arrangement of a patient's first and second jaws in a bite position at least partly defined by a first denture so that a relative spacing can be maintained between the patient's first and second jaws when using a new denture for the first jaw, the method comprising:obtaining a first digital 3D representation of the first denture for the first jaw, where the first digital 3D representation comprises geometrical data for artificial teeth of the first denture and for a first surface of a base of the first denture, which surface is configured to face a gum of the first jaw, where a first layer of impression material shaped according to a surface of the gum of the first jaw is arranged at the first surface of the base of the first denture, the first layer of impression material having a shape of the surface of the gum of the first jaw by having previously placed the first denture with the first layer of impression material at the surface of the gum of the first jaw;
obtaining a second digital 3D representation comprising geometrical data for the artificial teeth of the first denture and geometrical data for antagonist teeth in the second jaw, where the artificial teeth of the first denture and the antagonist teeth are arranged according to occlusion of the patient;
mapping the first digital 3D representation into a coordinate system of the second digital 3D representation;
deriving from the first digital 3D representation and the second 3D representation a third digital 3D representation comprising geometrical data for the surface of the gum of the first jaw in the coordinate system of the second digital representation;
obtaining a fourth digital 3D representation comprising geometrical data for the second jaw; and
mapping the fourth digital 3D representation into the coordinate system of the second digital 3D representation, and
using the geometrical data of the mapped first, second, and fourth digital 3D representations and the third digital 3D representation to determine the relative spacing of the surface of the gum of the first jaw and the antagonist teeth when using a new denture for the first jaw.

US Pat. No. 10,595,970

BONDING OF SOFT GINGIVAL TISSUES WITH ANATOMICAL AND OTHER DENTAL PROSTHESES

Esthetic Implant Solution...

1. A method for providing increased soft tissue adhesion to a prosthesis anchored in a dental implant, the method comprising:providing a prosthesis that is an anatomical healing abutment for promoting healing of gingival tissue around a subgingival void of a given tooth position and shaping of a gingival margin of a patient at the given tooth position, and which exhibits soft tissue adhesion during healing, the anatomical healing abutment comprising:
a cuff body having an anatomical subgingival portion extending from an implant end to the gingival margin of the patient, and an emergent crown portion extending from the subgingival portion and occlusally beyond the gingival margin of the patient; and
wherein the anatomical subgingival portion has an asymmetric cross section and an outer surface that is shaped to provide substantially custom filling of at least an emergence portion of the subgingival void where a natural tooth once emerged from the void, or where a tooth would have emerged from the void, the subgingival portion thus being shaped to anatomically fill and fully support gingival tissue around the subgingival void to prevent or minimize slump of gingival tissue into the subgingival void,
wherein at least the outer surface of the anatomical subgingival portion of the anatomical healing abutment is (i) formed from a material which accepts adhesion of the soft tissue surrounding the prosthesis; (ii) is mechanically or chemically treated at the outer surface thereof so as to accept adhesion of the soft tissue surrounding the anatomical healing abutment; or (iii) both (i) and (ii);
placing the subgingival portion of the anatomical healing abutment into the subgingival void of a given tooth position, and coupling the anatomical healing abutment into an implant disposed below the anatomical healing abutment; and
allowing the soft tissue to heal around the placed anatomical healing abutment such that the soft tissue adheres to the anatomical healing abutment, providing a seal around the anatomical healing abutment which:
reduces or prevents ingress of pathogenic microbes between the anatomical healing abutment and the soft tissue, and/or
reduces or prevents recession of the soft tissue around the anatomical healing abutment.

US Pat. No. 10,595,966

METHODS AND APPARATUSES FOR DENTAL IMAGES

Align Technology, Inc., ...

1. A method for remotely and automatically pre-screening a patient for an orthodontic treatment prior to treatment by a dental professional, the method comprising:guiding a user, with a mobile telecommunications device having a camera and a screen, to take a series of images of the patient's teeth in a plurality of predetermined viewing angles by sequentially, for each predetermined viewing angle:
displaying, on the screen, an overlay comprising an outline of teeth in one of the plurality of predetermined viewing angles, wherein the overlay is displayed atop an image of the series of images of the patient's teeth; and
capturing the image of the patient's teeth when the overlay approximately matches the image of the patient's teeth in the one of the predetermined viewing angles's teeth;
transmitting the captured images to a remote location to automatically determine if the patient is a candidate for the orthodontic treatment based on the captured images; and
displaying, on the screen of the mobile telecommunications device, an indicator that the patient is, or is not, a candidate for the orthodontic treatment.

US Pat. No. 10,595,964

INTRA-ORAL APPLIANCE FOR FIELD ISOLATION AND MOISTURE CONTROL

1. An intra-oral simultaneous bilateral inter arch isolation appliance comprising:a body having, in superior plan view, a generally W-shaped configuration bisected by a medial plane, said body having a singular, unitary seamlessly integral construction defining:
a tongue crib of generally U-shaped configuration in superior plan view and bisected by said medial plane, said U-shaped configuration being closed at an anterior end thereof and open at a posterior end thereof to receive a patient's tongue through the open posterior end and shield said tongue behind the closed anterior end thereof;
a first cheek retractor wing spaced laterally of the medial plane to a first side thereof and reaching anteriorly-posteriorly therealong;
a second cheek retractor wing spaced laterally of the medial plane to an opposing second side thereof and reaching anteriorly-posteriorly therealong;
first and second transitions respectively joining the first and second cheek retractor wings to respective halves of the tongue-crib on the opposing sides of the medial plane at the open posterior end of the tongue crib such that the tongue crib projects anteriorly from the transitions within a space bound between the cheek retractor wings;
a first commissure cradle located at a first terminal end of the W-shaped configuration and attached to an anterior end of the first cheek retractor wing for hooked engagement of the first commissure cradle about a patient's first oral commissure;
a second commissure cradle located at a second terminal end of the W-shaped configuration and attached to an anterior end of the second cheek retractor wing for hooked engagement of the second commissure cradle about a patient's second oral commissure; and
a respective gripping handle protruding laterally outward from at least one of the commissure cradles at a distal end thereof furthest from the associated cheek retractor wing;
whereby in a patient worn position of said appliance, each cheek retractor wing runs buccally along a respective left or right half of a patient's mandibular and maxillary dental arches to retract and isolate buccal mucosa from said dental arches, the transitions curve posteriorly around molars of the dental arches between the patient's maxillary tuberosity and retromolar pad, and the tongue crib accommodates and shields the patient's tongue between said halves of the dental arches, thereby isolating the tongue from said dental arches.

US Pat. No. 10,595,963

DISPENSER, AND DISPENSER AND CARTRIDGE

GC Corporation, Shizuoka...

1. A dispenser comprising:a guide shaft;
a housing, accommodating the guide shaft, and supporting the guide shaft movably in mutually opposite first and second directions along an axial direction of the guide shaft;
a slide block slidably mounted on the guide shaft;
a piston shaft having a first end mounted on the slide block, and a second end, opposite to the first end, projecting from the housing as the slide block moves in the first direction;
a handle projecting from the housing in a direction non-parallel to the axial direction of the guide shaft;
a slide bar having a third end rotatably supported on the housing, and a fourth end, opposite to the third end, approaching the handle when the slide bar is rotated in a rotating direction around the third end;
a lever, rotatably supported on the fourth end of the slide bar, and squeezable with respect to the handle; and
an engaging piece provided on the third end of the slide bar and engaging a guide groove formed in the guide shaft, wherein the engaging piece moves the guide shaft in the first direction when the slide bar is rotated in the rotating direction around the third end to approach the handle.

US Pat. No. 10,595,962

ULTRASONIC ENDODONTIC SURGICAL INSTRUMENT

HAN INSTRUMENTS, LLC, Va...

1. An endodontic instrument for ultrasonic root end retro-preparation, comprising:a plurality of segments extending from a proximal base to a bent distal tip, the proximal base having an opening at a proximal end thereof adapted to receive an actuator of an ultrasonic energy generator, the segments being attached together to enable propagation of ultrasonic energy from the proximal base to the distal tip, the segments including a first elbow segment attached to the proximal base and a swivel segment located distal to the first elbow segment, the swivel segment enabling rotation of the bent distal tip relative to the first elbow segment, wherein the segments are made of the same metal, and wherein the plurality of segments define a double-angled shape having a length of between about 1-2 in.

US Pat. No. 10,595,961

ENDODONTIC INSTRUMENTS DISPLAYING COMPRESSIBILITY

1. A method of preparing an endodontic cavity space, the method comprising:inserting an endodontic instrument into the endodontic cavity space, wherein the endodontic instrument comprises:
a shank configured for attachment to a motor to drive the endodontic instrument about a first axis, and
a body extending from the shank by a length, the body having a working surface between: (i) a shank end portion where the working surface and the shank meet and (ii) a tip end portion where the working surface meets a tip of the endodontic instrument, the working surface including multiple edges, at least a portion of the working surface being tapered such that the tip end portion has a diameter that is less than a diameter of the shank end portion, the working surface comprising a plurality of transverse cross-sections, each transverse cross-section having a center of mass and multiple sides, the working surface having a center of mass path defined by the centers of mass of the plurality of transverse cross-sections of the body,
wherein the endodontic instrument is configured to be radially compressible between: (i) an unconstrained configuration in which at least a portion of the center of mass path between the tip end portion and the shank end portion is offset from the first axis and spirals around the first axis along a length of the first axis, and (ii) a radially constrained configuration in which the portion of the center of mass path is more aligned with the first axis than in the unconstrained configuration, and
preparing of the endodontic cavity space by rotating the endodontic instrument about the first axis while the endodontic instrument is in the endodontic cavity space,
wherein, during the rotating, a cutting perimeter of the endodontic instrument enlarges such that the endodontic cavity space is prepared by rotating the endodontic instrument singularly, thereby eliminating a need for rotating two or more endodontic instruments of increasing sizes for the preparing of the endodontic space, and
wherein, after the preparing of the endodontic cavity space by rotating the endodontic instrument singularly and without rotating two or more endodontic instruments of increasing sizes, the endodontic cavity space is sized for filling.

US Pat. No. 10,595,960

ULTRASONIC METHODS AND DEVICES FOR DENTAL TREATMENT

SMILESONICA INC., Edmont...

1. A system for use in emitting ultrasound to a dental area, the system comprising:an intra-oral dental attachment for providing ultrasound emissions to the dental area; the dental attachment comprising at least one flexible array of cooperative ultrasound transducers; and
controlling means for controlling the ultrasound emissions, the controlling means being in communication with the dental attachment;
wherein the at least one flexible array of cooperative ultrasound transducers comprises:
at least one buccal side transducer and at least one lingual side transducer, which are each independently and selectively controllable by the controlling means to: emit ultrasound in an ultrasound emitting mode;
and to sense at least one stimulus and provide feedback in an ultrasound sensing mode; and
wherein the controlling means independently and selectively controls the at least one buccal side transducer and at least one lingual side transducer based, at least in part, on the feedback, and
wherein the controlling means comprises switching circuitry coupled to the at least one buccal side transducer and at least one lingual side transducer, the switching circuitry comprising one or more multiplexer/demultiplexer circuits selectively switching each of the at least one buccal side transducer and the at least one lingual side transducer between the ultrasound emitting mode and the ultrasound sensing mode.

US Pat. No. 10,595,958

WIRELESSLY DETECTABLE OBJECTS FOR USE IN MEDICAL PROCEDURES AND METHODS OF MAKING SAME

COVIDIEN LP, Mansfield, ...

1. A method of manufacturing wirelessly detectable objects for use in medical procedures, the method comprising:supplying a plurality of pouches, wherein each of the pouches contains a respective encapsulated wireless transponder, the encapsulated wireless transponder retained in the respective pouch via a respective plurality of stitches about a perimeter of each of the pouches;
attaching a respective one of the pouches to a piece of absorbent material via at least one or more stitches of the respective plurality of stitches, the pouch containing the respective encapsulated wireless transponder;
for each of a plurality of pieces of the absorbent material, folding the respective piece of absorbent material to form a folded piece of absorbent material; and
packaging the folded piece of absorbent material.

US Pat. No. 10,595,957

MARKER MATERIALS AND FORMS FOR MAGNETIC MARKER LOCALIZATION (MML)

ENDOMAGNETICS LTD, (GB)

1. A magnetic marker for marking a site in tissue in the body, the marker comprising at least one magnetically soft material having a magnetic coercivity of less than 100 Oe with a magnetic mass susceptibility of greater than 0.05 m3 kg?1 and being deformable between a packed non-spherical configuration prior to deployment having a higher ratio of maximum magnetic response to minimum magnetic response (ratio of magnetic anisotropy of susceptibility) compared to a deployed/unpacked configuration after deployment wherein the marker has a ratio of magnetic anisotropy of susceptibility of less than 5.

US Pat. No. 10,595,956

MARKER LOADING ASSEMBLY

Camtomsam AB, Huddinge (...

1. An imaging marker loading assembly for transferring an elongated positioning marker from a loader needle of said assembly into an insertion needle of a medical insertion device, the marker loading assembly comprising:an elongated hollow housing having a manoeuvring end and a marker transfer end,
a loader needle mounted within said loading assembly along a longitudinal axis of said assembly, said loader needle supporting therein said elongated positioning marker until the elongated positioning marker is transferred to said insertion needle, said elongated positioning marker having one or more indentations distributed along a longitudinal axis of said elongated positioning marker for enabling the elongated positioning marker to fold when inserted into tissue, wherein the elongated positioning marker is configured to form an entangled ball when inserted into tissue, and
a transfer opening provided at the marker transfer end and being adapted to receive a distal end of the insertion needle, said transfer opening being provided with a shape gradually opening up in a direction away from said manoeuvring end, and said transfer opening at its narrow end leading to a transfer channel arranged along said longitudinal axis,
a removable transport protecting member being an elongated rod structured to be inserted into a loading end of the loader needle, frictionally held within the loader needle, and easily removed from the loader needle when the assembly is to be used,
wherein the transfer channel has a circular cross-sectional shape having a diameter larger than an outer diameter of the insertion needle or of an outer protective sleeve provided on the outside of the insertion needle, and wherein a loading end of the loader needle is concentrically arranged in the transfer channel such that an annular space having a predetermined length along the longitudinal axis is provided around the loading end,
wherein the outer diameter of the loader needle is smaller than an inner diameter of the insertion needle, which enables the distal end of the insertion needle to be inserted into said annular space in the transfer channel and simultaneously the loading end of the loader needle to be inserted into the distal end of the insertion needle to set said assembly in a marker loading ready state, and
wherein the loading assembly further comprises a transfer mandrel, said transfer mandrel being adapted to be arranged within said loading needle and being arranged to receive a force in the direction towards the insertion needle and thereby achieve transfer of the elongated positioning marker from the loader needle into the distal end of the insertion needle.

US Pat. No. 10,595,954

NEEDLE BREAST BIOPSY SYSTEM AND METHOD FOR USE

Hologic, Inc., Marlborou...

1. An upright x-ray mammography imaging system comprising:a gantry;
an x-ray tube configured to rotate relative to the gantry over an angular range, wherein the x-ray tube emits x-rays within a field;
an x-ray receptor configured to rotate relative to the gantry and disposed in a plane normal to the x-ray tube so as to receive the emitted x-rays;
a compression platform connected to the gantry and encasing the x-ray receptor;
a compression paddle spaced apart from each of the x-ray tube and the compression platform, wherein the compression paddle and the compression platform are configured to compress a breast of a patient, and wherein the compression paddle is releasably fittable onto the gantry; and
a needle biopsy assembly releasably couplable to the gantry between the x-ray tube and the compression platform, wherein the needle biopsy assembly is removable from the gantry separate from the compression paddle, the needle biopsy assembly comprising:
a first handle and a second handle, wherein at least one of the first handle and the second handle comprises a coupling mechanism to releasably couple the needle biopsy assembly to the gantry;
a support structure extending between the first handle and the second handle;
a fixed support arm coupled to the support structure;
an angular support arm coupled to the fixed support arm, wherein the angular support arm extends at an angle offset from the plane of the x-ray receptor;
a holster mount moveably coupled to the angular support arm;
a biopsy device coupled to the holster mount wherein the holster mount is adapted to position the biopsy device proximate a target location, the biopsy device comprising a needle, wherein a portion of the needle is positionable so as to be disposed at the angle offset between the compression platform and the compression paddle to biopsy the compressed breast, and wherein when the needle biopsy assembly is coupled to the gantry, the holster mount and the biopsy device are positioned outside of the field of x-rays emitted by the x-ray tube so that image artifacts by the holster mount and the biopsy device are not formed in an x-ray image; and
a needle support coupled to the angular support arm for stabilizing an end of the needle.

US Pat. No. 10,595,953

ON PATIENT SURGICAL PROCEDURAL INSTRUMENT TRAY

Connected Rock, Inc., Ca...

7. An apparatus for placement on a patient to support one or more instruments for a surgical procedure in which the patient is at least partially covered by a surgical drape, the apparatus comprising:a tray configured for placement on the patient for the surgical procedure, the tray having a top surface to support the one or more instruments;
a sloped periphery that defines a rectangle that measures at least 8.5 inches long and 11 inches wide, and that slopes up from the top surface of the tray to form a wall at the sloped periphery of the tray to retain the one or more instruments supported by the top surface of the tray;
a pair of slots formed in the tray proximate the sloped periphery on and between opposing sides of the length of the rectangle;
a tray drape slideably positioned through the pair of slots and on top of the top surface of tray, the tray drape having a length and a width to form a tray base surface on top of the top surface of the tray and opposing end drapes on opposite sides of the tray when the tray drape is slideably positioned through the one or more slots;
a set of clips integrated with each of the opposing end drapes of the tray drape for attaching the tray drape to the surgical drape of the patient during the surgical procedure; and
wherein the tray is configured for placement atop the torso of the patient.

US Pat. No. 10,595,952

PROCESS AND APPARATUS FOR MANAGING MEDICAL DEVICE SELECTION AND IMPLANTATION

Sight Medical, LLC, Alex...

1. A method of assisting an orthopedic implant procedure in an operating room with a display communicating with a computer system, the method comprising the steps of:a. loading on the computer system a sub-set of surgical instruments and implant instruments arranged into a substantially specific order based upon a determination of a sequence of bone cuts to be performed in the procedure;
b. presenting on the display images of the surgical instruments and implant instruments in the substantially specific order;
c. on the display, advancing through the substantially specific order of the surgical instruments and implant instruments;
d. wherein a user interface to the computer system is located in the operating room and the user interface allows a user to control the computer system's advancement though the substantially specific order on the display;
e. providing (i) a surgical table in the operating room, (ii) a camera viewing the surgical table, and (iii) the computer system receiving images from the camera;
f. loading into memory of the computer system a sub-set of surgical instruments and implant instruments arranged into a substantially specific order;
g. placing the sub-set of surgical instruments and implant instruments on the surgical table;
h. capturing an image with the camera of the surgical instruments and implant instruments on the surgical table; and
i. determining which of the surgical instruments and implant instruments loaded into the computer memory are present in the image of surgical instruments and implant instruments.

US Pat. No. 10,595,950

FERROMAGNETIC SHAPED MEMORY ALLOY NANO-ACTUATOR AND METHOD OF USE

University of Washington,...

1. A nano-actuator comprising a first head portion formed from a ferromagnetic material and a helical portion extending from the head portion, the helical portion comprising a compliant ferromagnetic shape memory alloy, wherein the helical portion is configured to be elastically compressible by applying an external magnetic field, and to expand when the external magnetic field is removed.

US Pat. No. 10,595,949

SPLAYED CABLE GUIDE FOR A MEDICAL INSTRUMENT

Intuitive Surgical Operat...

1. An apparatus, comprising:a shaft of a medical instrument, a first cable, a second cable, and a cable guide;
the cable guide comprising a mounting surface, an inner surface, a first guide surface, and a second guide surface;
the inner surface defining a shaft opening into a shaft passageway defined by the shaft;
the first guide surface comprising a first bend portion transitioning to the inner surface, the first bend portion being characterized by a first bend radius about a first bend axis, the first bend axis being offset from the mounting surface by a first offset distance;
the second guide surface comprising a second bend portion transitioning to the inner surface, the second bend portion being characterized by a second bend radius about a second bend axis, the second bend axis being offset from the mounting surface by a second offset distance, the second offset distance being different than the first offset distance;
the first cable being routed along the first guide surface, around the first bend portion, and through the shaft opening; and
the second cable being routed along the second guide surface, around the second bend portion, and through the shaft opening.

US Pat. No. 10,595,947

SURGICAL INSTRUMENT SHAFT WITH EMBEDDED OPTICAL FIBER

Intuitive Surgical Operat...

1. A surgical instrument shaft comprising:a hollow tube including an inner wall surface and an outer wall surface comprising: a base material having a reinforcing glass material embedded therein between the inner surface and outer wall surface; and
an optical fiber embedded within the base material between the inner wall surface and the outer wall surface.

US Pat. No. 10,595,945

ROBOTIC SURGICAL ASSEMBLIES

Covidien LP, Mansfield, ...

1. A surgical assembly for use with and for selective connection to a robotic arm, the surgical assembly comprising:an electromechanical surgical instrument including:
a housing portion supporting a driven member therein; and
a shaft having a proximal end supported by the housing portion and a distal end having an end effector operably coupled to the driven member; and
an instrument drive unit including:
a first motor configured to be operably coupled to the driven member of the electromechanical surgical instrument;
a second motor configured to be coupled to the housing portion of the electromechanical surgical instrument to effect rotation of the electromechanical surgical instrument; and
a feedback assembly including:
control circuitry in communication with the second motor and configured to sense a change in a condition of the second motor;
a first annular member having a surface feature projecting therefrom; and
a second annular member disposed adjacent the first annular member, the second annular member having a first surface feature projecting therefrom, circumferentially aligned with the surface feature of the first annular member such that upon a threshold amount of rotation of the first annular member, the surface feature of the first annular member abuts the first surface feature of the second annular member to change the condition of the second motor.

US Pat. No. 10,595,942

TECHNIQUES FOR GENERATING A BONE PLATE DESIGN

Stryker European Holdings...

1. A method of generating a data set that geometrically defines a bone plate design for a bone plate with a plurality of fixation openings configured to receive a fixation member for fixing the bone plate to bone, the method comprising:accessing data indicative of a maxillofacial anatomy of a patient and generating a three-dimensional preoperative model of said anatomy using said data;
simulating an osteotomy on the preoperative model to generate a three-dimensional modified model, the simulated osteotomy defining first and second bone cuts that results in a second bone portion separated from a first bone portion, the osteotomy resulting in an absence of the maxillofacial anatomy coupling the first and second bone portions together;
defining, on the modified model, a first plurality of fixation openings on the first bone portion and a second plurality of fixation openings on the second bone portion, wherein the first and second plurality of fixation openings are defined on the modified model based on shape data of the maxillofacial anatomy such that at least a spacing distance between the first plurality of fixation openings is different from a spacing distance between the second plurality of fixation openings; and
determining a monolithic three-dimensional structure for the bone plate that couples the first and second plurality of fixation openings in the modified model, wherein the monolithic three-dimensional structure for the bone plate has a shape that varies in each of three dimensions to arrange the second bone portion relative to the first bone portion in accordance with a desired post-operative orientation, each of the plurality of first and second fixation openings corresponding to an aperture in the bone plate for receipt of a fixation member.

US Pat. No. 10,595,939

SKIN TREATMENT APPARATUS UTILISING INTENSE PULSED LIGHT (IPL)

iPulse Limited, Swansea ...

1. A skin treatment apparatus comprising:a light source comprising a light emitting element for transmitting light energy to a skin and a capacitor for discharging an energy dose to the light emitting element;
at least one sensor for measuring a parameter of the skin, the capacitor configured to be charged from a power input independently of the measurement from the at least one sensor; and
a control system configured to determine a treatment energy dose to be delivered, the treatment energy dose being optimized using a measurement from the sensor,
the control system further configured to start delivery of the treatment energy dose based upon a user input and then to terminate discharge of the capacitor upon delivery of the treatment energy dose before discharge of the capacitor is complete.

US Pat. No. 10,595,937

SYSTEM FOR OPTIMIZED COUPLING OF ABLATION CATHETERS TO BODY TISSUES AND EVALUATION OF LESIONS FORMED BY THE CATHETERS

St. Jude Medical, Atrial ...

1. A system for diagnosis or treatment of tissue in a body, comprising:an ablation catheter, comprising:
a deformable, elongate shaft having proximal and distal ends;
a first ablation delivery member disposed proximate said distal end of said deformable, elongate shaft, said first ablation delivery member configured to deliver ablation energy to ablate said tissue, said first ablation delivery member disposed about a longitudinal axis of said deformable, elongate shaft and having proximal and distal ends, said first ablation delivery member including at least one elongate slit configured to permit movement of the ablation delivery member laterally and axially from a first position to a second position relative to said longitudinal axis between said proximal and distal ends of said first ablation delivery member;
a lumen located within the ablation delivery member, the lumen adapted to deliver fluid configured to control the temperature of the first ablation delivery member;
a return lumen configured to draw the fluid away from the first ablation delivery member;
a membrane positioned over at least a portion of the at least one elongate slit and an exterior surface of the ablation delivery member, the membrane configured to prevent the fluid from flowing out of the ablation delivery member to provide a closed-loop pathway between the lumen and the return lumen;
a first sensing electrode disposed proximate said first ablation delivery member, said first sensing electrode configured to generate a first signal indicative of electrical activity in said tissue;
a force sensor disposed proximate the first ablation delivery member, said force sensor configured to generate a second signal; and
an electronic control unit configured to control delivery of said ablation energy from said first ablation delivery member responsive to said first signal and to determine a degree of coupling between said first ablation delivery member and said tissue from the first signal and determine a contact force responsive to said second signal, wherein the degree of coupling comprises determining a value for at least one component of a complex impedance between said first ablation delivery member and said tissue, and wherein the electronic control unit is further configured to use the first signal and the second signal to adjust the application of energy to the first ablation delivery member.

US Pat. No. 10,595,934

ELECTROSURGICAL UNIT PENCIL APPARATUS AND SHROUD HAVING DIRECTED ILLUMINATION

I.C. Medical, Inc., Phoe...

1. An electrosurgery pencil comprising:a handpiece having an open first end;
an electrode contained within at least a portion of the handpiece wherein at least a portion of the electrode extends beyond the open first end of the handpiece;
at least one electrical contact in communication with said electrode for enabling at least one of cutting and coagulation during a medical procedure; and
at least one lighting element located near the open first end of the handpiece wherein said at least one lighting element is connected to said at least one electrical contact so that said at least one lighting element turns on when the electrode is being used for at least one of cutting and coagulation and turns off when said electrode is not in use.

US Pat. No. 10,595,933

MULTIFUNCTIONAL VESSEL SEALING AND DIVIDER DEVICE

COVIDIEN LP, Mansfield, ...

1. An electrosurgical forceps, comprising:an end effector including first and second jaw members, the first jaw member having a proximal portion including an inner surface having a first jaw guide member disposed thereon and a distal portion including a first tissue contacting surface having stepped surfaces, the second jaw member having a proximal portion including an inner surface having a second jaw guide member disposed thereon and a distal portion including a second tissue contacting surface having stepped surfaces, the inner surfaces of the proximal portions of the first and second jaw members facing each other, each of the first and second tissue contacting surfaces having a shear edge disposed between the stepped surfaces,
the first and second jaw members vertically movable between an open position and a first approximated position in which the first and second tissue contacting surfaces vertically oppose and laterally align with each other, and laterally movable between the first approximated position and a second approximated position to laterally displace the first and second tissue contacting surfaces with respect to each other, the first and second jaw guide members controlling an open angle between the first and second jaw members during movement between the first approximated position and the second approximated position; and
first and second elongated shaft members that cooperate to define the end effector, the first jaw member disposed on a distal end portion of the first elongated shaft member and the second jaw member disposed on a distal end portion of the second elongated shaft member, the first and second elongated shaft members coupled together by a pivot pin extending through openings defined in respective first and second intersection portions of the first and second elongated shaft members, at least one of the first and second elongated shaft members pivotable with respect to the other of the first and second shaft members about at least two axes.

US Pat. No. 10,595,932

ELECTROSURGICAL INSTRUMENT WITH A KNIFE BLADE LOCKOUT MECHANISM

Covidien LP, Mansfield, ...

1. An electrosurgical forceps, comprising:a shaft;
a drive tube selectively translatable within the shaft between proximal and distal positions;
first and second jaw members operably coupled to the drive tube and movable between open and clamping positions as the drive tube translates between the proximal and distal positions;
a knife blade movable relative to the first and second jaw members and configured to cut tissue disposed therebetween; and
a knife blade lockout mechanism supported within the drive tube by a pivot pin, the knife blade lockout mechanism configured to pivot about the pivot pin as the drive tube translates between the proximal and distal positions to selectively prevent the knife blade from moving relative to the first and second jaw members, wherein the shaft includes a first slot defined therein and the drive tube includes a second slot defined therein, the knife blade lockout mechanism configured to pivot through the first and second slots as the knife blade lockout mechanism pivots about the pivot pin.

US Pat. No. 10,595,931

LIQUID FEEDER AND TREATMENT APPARATUS

OLYMPUS CORPORATION, Tok...

1. A liquid feeder mounted on a treatment instrument including an elongate member with a longitudinal axis, a handle arranged at a proximal end of the elongate member, and a rotation knob arranged at a distal end of the handle and configured to rotate the elongate member about the longitudinal axis, the liquid feeder comprising:a main tube disposed along the elongate member and configured to flow a liquid to an outer circumference of the elongate member;
a connection section disposed on a proximal end side of the main tube, the connection section including a connector connected to a fist end of a liquid feed tube, a second end of the liquid feed tube being connected to a liquid source, and the connection section is configured to connect an interior of the main tube with an interior of the liquid feed tube via the connector;
a seal member disposed inside the connection section and configured to form a watertight seal between the connection section and the elongate member; and
a fixing section rotatably attached to a proximal end of the connection section, the fixing section, the fixing section being configured to: pivot with respect to the connection section into a fixed position relative to the handle, the connection section being disposed at a distal end of the rotation knob, and
maintain an orientation of the connection section with respect to the handle when the fixing section is in the fixed position and while the elongate member of the treatment instrument is rotated about the longitudinal axis with respect to the handle.

US Pat. No. 10,595,930

ELECTRODE WIPING SURGICAL DEVICE

Ethicon LLC, Guaynabo, P...

1. A surgical instrument comprising:a handle assembly;
a shaft coupled to a distal end of the handle assembly; and
an end effector coupled to a distal end of the shaft, the end effector comprising:
a first jaw;
a second jaw, wherein the first jaw and the second jaw cooperate to capture tissue therebetween;
the first jaw comprising a first lateral side, a second lateral side, and a third side connecting the first and second lateral sides and facing the second jaw such that the third side is positioned closest to the second jaw as the second jaw closes with the first jaw;
a stapling member configured to fire one or more staples between the first and second jaws; and
an elongated electrode secured to the first jaw, the elongated electrode comprising:
a first long portion that runs longitudinally along the first lateral side of the first jaw from a first proximal point on said first lateral side beginning near a joint connecting the first jaw to the second jaw and extending to a distal end of said first lateral side;
a second portion electrically coupled to the first long portion that runs along a distal end of the third side of the first jaw such that the second jaw closes onto the second portion when the second jaw closes onto the first jaw;
a third long portion electrically coupled to the second portion that runs longitudinally along the second lateral side of the first jaw from a distal end of said second lateral side and extending to a second proximal point on said second lateral side beginning near the joint connecting the first jaw to the second jaw;
a fourth portion running substantially perpendicular to the longitudinal direction of the first long portion and connecting a distal end of the first long portion to the second portion; and
a fifth portion running substantially perpendicular to the longitudinal direction of the third long portion and connecting a distal end of the third long portion to the second portion;
wherein the first long portion and the third long portion are positioned on a first plane distal to the second jaw, and the second portion is positioned on a second plane parallel to the first plane and proximal to the second jaw; and
wherein the elongated electrode is configured to transmit electrosurgical energy throughout the entirety of the first long portion, the second portion, the third long portion, the fourth portion and the fifth portion, to coagulate tissue upon wiping the end effector against the tissue.

US Pat. No. 10,595,929

SURGICAL INSTRUMENTS WITH FIRING SYSTEM OVERLOAD PROTECTION MECHANISMS

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising: an end effector; a trigger actuatable between a first position and a second position; a firing beam comprising a tissue cutting surface movable from a proximal position to a distal position through the end effector; an actuation drive operably coupled to the firing beam, the actuation drive movable between an unactuated position and an actuated position in response to actuation of the trigger to move the firing beam from the proximal position to the distal position; a housing comprising a toggle assembly transitionable between a folded configuration and an expanded configuration, wherein the expanded configuration of the toggle assembly corresponds to the distal position of the firing beam; wherein in the folded configuration the toggle assembly operably couples the trigger to the actuation drive such that actuation of the trigger causes the actuation drive to move the firing beam; wherein in the expanded configuration the toggle assembly decouples the trigger from the actuation drive such that actuation of the trigger does not cause the actuation drive to move the firing beam; and a resetting member operable to return the toggle assembly to the folded configuration.

US Pat. No. 10,595,928

COMBINATION UNILATERAL/BILATERAL JAWS ON A SURGICAL INSTRUMENT

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing supporting first and second actuators thereon;
a first jaw member and a second jaw member;
a first drive member defining a longitudinal axis and operatively coupled between the first actuator and the first jaw member such that manipulation of the first actuator induces pivotal movement of the first jaw member about a pivot axis, the pivot axis disposed at a non-parallel angle relative to the longitudinal axis;
a second drive member operatively coupled between the second actuator and the second jaw member such that manipulation of the second actuator induces pivotal movement of the second jaw member about the pivot axis; and
a coupling member operatively associated with the first drive member and the second drive member, the coupling member selectively movable between a locked configuration and an unlocked configuration, wherein in the locked configuration the first drive member and the second drive member are coupled to one another and move concurrently to pivot the first jaw member and the second jaw member about the pivot axis in a bilateral manner, wherein the coupling member includes a peg coupled to the first drive member, and wherein the second drive member includes a plurality of holes defined therein for receiving the peg when the coupling member is moved to the locked configuration.

US Pat. No. 10,595,927

COMBINATION MEDICAL DEVICE

GYRUS ACMI, INC., Southb...

1. A device comprising:a first arm having a first distal end and a first proximate end;
a second arm having a second distal end and a second proximate end, the second arm interconnected to the first arm, wherein the first arm and the second arm are biased towards each other by a closing force;
a shuttle;
a biasing member disposed between the first arm and the second arm, the biasing member having a first position that provides an opening force that biases the first arm and the second arm away from each other against the closing force, and having a second position that does not oppose the closing force, the biasing member having a first connector pivotally connected to the first arm and a second connector pivotally connected to the second arm, and the first connector and the second connector are pivotally connected to the shuttle at a pivot point, the first connector having a first surface and the second connector having a second surface, and the first surface contacts the second surface when the biasing member is in the first position.

US Pat. No. 10,595,926

ENERGY-BASED MEDICAL DEVICES

Covidien LP, Mansfield, ...

1. A medical device, comprising:first and second electrically and thermally conductive tissue treating surfaces;
an electrical conductor disposed in electrical communication with the first tissue treating surface and configured to conduct RF energy to the first tissue treating surface for conducting RF energy through tissue disposed between the first and second tissue treating surfaces for heating tissue via Joule heating to treat tissue; and
an electrically insulative thermal conductor disposed in thermal communication with the first tissue treating surface and configured to conduct heat to the first tissue treating surface for heating tissue adjacent the first tissue treating surface via conductive heating to facilitate treating tissue,
wherein the electrically insulative thermal conductor is coupled to heat-generating electronics for conducting the heat from the heat-generating electronics to the first tissue treating surface, and wherein the heat-generating electronics include at least one of a control unit or a power source.

US Pat. No. 10,595,925

MEDICAL SYSTEM AND METHOD OF USE

Tsunami MedTech, LLC, Me...

1. A method for thermally treating tissue comprising:providing a probe body having a flow channel extending therein to an outlet in a working end;
introducing a flow of a liquid media through the flow channel; and
applying energy to the tissue by inductively heating a portion of the probe body sufficient to produce a flowing media by vaporizing the liquid media within the flow channel causing pressurized ejection of the flowing media from the outlet to the tissue;
determining a vapor quality of the flowing media by measuring at least one parameter of the flowing media; and
modulating an operating parameter used to produce the flowing media based on the vapor quality of the flowing media.

US Pat. No. 10,595,924

ELECTROSURGICAL SNARE DEVICE

Apyx Medical Corporation,...

1. An electrosurgical device comprising:a housing having a longitudinal axis; a support shaft attached to a distal end of the housing, the support shaft having a longitudinal axis substantially aligned with the longitudinal axis of the housing;
a tube at least partially disposed in the support shaft, the tube including a plurality of apertures disposed along a length of the tube; and
an electrically conducting spring disposed around the tube, the electrically conducting spring including a plurality of coils spaced apart from each other, where a spacing of the coils coincides with a spacing of the plurality of apertures, the electrically conducting spring adapted to move along the tube such that at different points in time the plurality of coils are disposed over the plurality of apertures or between the plurality of apertures or between the plurality of apertures,
wherein a gas assisted electrosurgical effect is formed at each of the plurality of apertures when an inert gas flows through the tube and the electrically conducting spring is energized, the gas assisted effect being enhanced when the plurality of coils are disposed over the plurality of apertures and the gas assisted effect being reduced when the plurality of coils are disposed between the plurality of apertures.

US Pat. No. 10,595,923

METHOD AND SYSTEM RELATED TO ELECTROSURGICAL PROCEDURES

ArthroCare Corporation, ...

1. An electrosurgical system comprising:a processor;
a memory coupled to the processor;
wherein the memory stores a program that, when executed by the processor, causes the processor to:
monitor an electrical parameter associated with a voltage generator during periods of time when energy is being delivered to an active electrode of an electrosurgical wand; and
determine, based on the electrical parameter, a presence of a wand condition of the electrosurgical wand, the wand condition being at least one selected from the group consisting of: a surface area of the active electrode is less than a predetermined threshold surface area; and that the surface area of the active electrode is approaching the predetermined threshold surface area.

US Pat. No. 10,595,921

SLIDING CROSS-FLUOROSCOPY AUXILIARY APPARATUS FOR INSERTING ORTHOPEDIC PEDICLE SCREW

1. A sliding cross-fluoroscopy auxiliary apparatus for inserting an orthopedic pedicle screw, comprising: a holder and a lifting pillar on the holder, wherein a supporting arm is provided on a top end of the lifting pillar, and a telescopic shaft is arranged inside the supporting arm; a first end of the telescopic shaft is connected to a first driver, and a second end of the telescopic shaft is connected to an A arc; the first driver drives the telescopic shaft to extend out, draw back or rotate; a second driver is arranged at a joint between the A arc and the telescopic shaft, and a B arc is placed between the second device and the A arc; the second driver drives the B arc to rotate along the A arc; a third driver is arranged at a bottom end of the lifting pillar, which drives the lifting pillar to move up, move down or rotate;wherein a first integrated tube and a first collimator are provided on a left end of the A arc, and a first image intensifier is provided on a right end of the A arc; axes of the first integrated tube, the first collimator and the first image intensifier coincide with each other; a second integrated tube and a second collimator are provided on an upper end of the B arc, and a second image intensifier is provided on a lower end of the B arc; axes of the second integrated tube, the second collimator and the second image intensifier coincide with each other;
wherein guiding devices are respectively provided at exterior sides of the first collimator and the second collimator, each of which comprises a guiding rod, a sliding cylinder, a connecting rod, and a sleeve cylinder; wherein a pedicle driller is arranged on the sleeve cylinder; bottom portions of the guiding rods are respectively connected to exterior sides of the first integrated tube of the A arc and the second integrated tube of the B arc, and axes of the guiding rods respectively coincide with the axes of the first collimator of the A arc and the second collimator of the B arc; the guiding rod passes through the sliding cylinder, which enables the sliding cylinder to move along the guiding rod or to lock the guiding rod; a first end of the connecting rod is connected to the sliding cylinder, and a second end of the connecting rod is connected to the sleeve cylinder; the guiding rod, the sliding cylinder, the sleeve cylinder and the pedicle driller share a same axis which coincides with axes of the first collimator, the second collimator, a ray source and a receiver; the B arc guides an inserting direction of the orthopedic pedicle screw while the A arc prevents the orthopedic pedicle screw from excessive inserting; the A arc comprises a first fluoroscopy formed by the first integrated tube, the first collimator and the first image intensifier on both sides, and the B arc comprises a second fluoroscopy formed by the second integrated tube, the second collimator and the second image intensifier on both sides.

US Pat. No. 10,595,919

SURGICAL TOOLS WITH POSITIONAL COMPONENTS

Medovex Corp., Tampa, FL...

1. A surgical tool comprising:an upwardly extending tubular support member having a longitudinally extending open channel, the tubular support member comprising a wall surrounding the open channel; and
a base pivotably and directly attached to the tubular support member with a pivot axis that extends above a bottom surface of the base and across a bottom portion of the tubular support member to allow the tubular support member to pivot back and forth over the bottom surface of the base,
wherein the base comprises first and second base members adapted to concurrently press against skin of a patient, one attached to each side of the tubular support member, each configured to move independent of the other.

US Pat. No. 10,595,918

HIGH-PRESSURE BALLOON CATHETER WITH PRESSURE REGULATING VALVE

1. An inflatable bone tamp comprising:an outer shaft defining a passageway;
an inner shaft positioned within the passageway, the inner shaft defining a lumen;
a balloon having a first end coupled to the outer shaft and a second end coupled to the inner shaft such that material can flow through the lumen and into the balloon and exit the balloon through a channel between the inner and outer shafts; and
a valve positioned within the channel, the valve being configured to move from a closed orientation in which the valve blocks the channel and an open orientation in which the valve does not block the channel.

US Pat. No. 10,595,917

BONE SCREW AND TOOL FOR USE THEREWITH

1. A bone screw, comprising:a shank portion having a proximal end and a distal end, wherein the shank portion includes at least one thread on an exterior surface thereof extending from adjacent the proximal end of the shank portion to adjacent the distal end of the shank portion; and
a head portion attached to the shank portion at the proximate end thereof, wherein the head portion includes a tool interface structure therein and wherein the tool interface structure includes a plurality of sidewalls, a floor and a tool lock recess located within at least one of the sidewalls; and wherein
the shank portion includes a cannulation passage extending longitudinally therethrough;
the cannulation passage defines an interior surface of the shank portion;
the shank portion includes at least one bone material aperture therein extending between the exterior surface of the shank portion and the interior surface of the shank portion;
the at least one bone material aperture extends through the at least one thread over a first partial length of the shank portion;
the at least one thread extends over a second partial length of the shank portion;
the first partial length is shorter than the second partial length;
the second partial length encompasses the first partial length;
the first partial length begins at a first distance from the proximate end of the shank portion;
the second partial length begins at a second distance from the proximate end of the shank portion; and
the first distance is greater than the second distance.

US Pat. No. 10,595,916

POLY-AXIAL FIXATION POSTS

Zimmer, Inc., Warsaw, IN...

1. A method of attaching an orthopedic device to a bone, the method comprising:locating a baseplate on a glenoid of a patient, the baseplate including at least a first fastener bore extending through the baseplate;
creating, by passing a bone removal tool through the first fastener bore, a first post hole in the glenoid for locating a first fixation post within the glenoid, wherein the first fixation post includes a quasi-spherical head with a shaft extending therefrom to a distal end of the first fixation post, the quasi-spherical head including a textured outer surface for contacting at least a first wall of the first fastener bore, the first fixation post also including a porous metal sleeve received on the shaft; and
driving the distal end of the first fixation post through the first fastener bore and into the first post hole such that the textured outer surface of the quasi-spherical head contacts at least the first wall of the first fastener bore so as to removeably lock the quasi-spherical head to the baseplate, wherein said driving creates an initial compression between the baseplate and the glenoid, and wherein the porous metal sleeve is configured to receive bone ingrowth into the porous metal sleeve for maintaining said initial compression between the baseplate and the glenoid.

US Pat. No. 10,595,915

BONE IMPLANT DEVICES, INSTRUMENTS AND METHODS OF USE

Paragon 28, Inc., Englew...

1. An implant insertion system, comprising:an insertion instrument with a first end and a second end, the insertion instrument comprising:
an opening extending into the insertion instrument from the second end;
a handle portion at the first end; and
a coupling member at the second end, wherein the opening is positioned in the coupling member; and
an implant comprising:
a first portion at a first end;
a second portion at a second end; and
an intermediate portion coupling the first portion to the second portion;
wherein the first portion is received within the opening of the insertion instrument and wherein the implant is a non-threaded implant.