US Pat. No. 10,244,960

BASKET STYLE CARDIAC MAPPING CATHETER HAVING SPLINE BENDS FOR DETECTION OF CARDIAC RHYTHM DISORDERS

Topera, Inc., Menlo Park...

1. A system for sensing multiple local electric voltages from an endocardial surface of a heart, comprising:a first elongate tubular member having a lumen, a proximal end and a distal end;
a basket assembly comprising:
a plurality of flexible splines guiding a plurality of flexible polymeric strips, the plurality of flexible polymeric strips each having a plurality of electrodes, the splines having proximal portions, distal portions and medial portions therein between;
a proximal anchor for securably affixing the proximal portions of the splines;
said proximal anchor being secured at the distal end of the first elongate tubular member;
a distal tip for securably affixing the distal portions of the splines, said proximal anchor and said distal tip defining a longitudinal axis therein between about which the splines are disposed;
wherein the basket assembly exhibits a substantially cylindrical shape when radially compressed and exhibits a radially expanded non-spherical shape when not radially compressed;
wherein at least some of the splines in the radially expanded non-spherical shape contain a distal excurvate outward bend disposed at the distal portion of the spline at a location near to the distal tip of the basket assembly to bend the splines back towards the proximal anchor;
wherein at least some of the splines in the radially expanded non-spherical shape contain a distal incurvate inward bend between said distal tip and said distal excurvate outward bends;
wherein, when the basket assembly is in said radially expanded non-spherical shape, the splines extend beyond the distal tip; and, when the basket assembly is in said radially expanded non-spherical shape, apices of the distal excurvate bends are disposed beyond the distal tip; and
wherein proximal portions of the flexible polymeric strips are disposed within the proximal anchor;
wherein the flexible polymeric strips comprise:
a polymeric substrate having an upper surface and an opposed lower surface with the plurality of electrodes disposed over a portion of the upper surface of the polymeric substrate;
a plurality of electrical traces disposed over a portion of the lower surface of the polymeric substrate in electrical communication with the plurality of electrodes by way of metal plated holes through the polymeric substrate;
a first polymeric covering disposed over the plurality of electrical traces and portions of the lower surface of the polymeric substrate not having the plurality of electrical traces thereon;
wherein the flexible polymeric strips are compressingly and thermally bonded to outer surfaces of second polymeric substrates to define flexible electrode assembly strips with substantially smooth and atraumatic overall outer surfaces.

US Pat. No. 10,244,959

VITAL INFORMATION MEASUREMENT DEVICE AND VEHICLE SEAT

TS Tech Co., Ltd., Saita...

1. A vital information measurement device comprising:a sheet-shaped sensor that is configured to detect a vital signal of a subject that is a human or an animal,wherein:the vital information measurement device is configured to measure vital information of the subject based on the vital signal detected by the sheet-shaped sensor,
the sheet-shaped sensor at least comprises a conductive line that forms a sensor body, and a conductive sheet fixing the conductive line,
the conductive line is disposed along an outer peripheral portion of the conductive sheet,
a sensor overlap reduction section configured to reduce partial overlapping of the sheet-shaped sensor when the subject directly or indirectly contacts the sheet-shaped sensor is provided in the sheet-shaped sensor, and
at least one or more cutouts are, as the sensor overlap reduction section, formed in the outer peripheral portion of the conductive sheet.

US Pat. No. 10,244,953

BIOLOGICAL INFORMATION DETECTING DEVICE AND ELECTRONIC APPARATUS

Seiko Epson Corporation, ...

1. A biological information detecting device comprising:a first light detector which receives light from a subject;
a second light detector which receives light from the subject;
a processing portion;
at least one light emitting portion which emits light to the subject; and
a light-transmissive member which is provided at a position closer to the subject than the first light detector and the second light detector, through which light from the subject is transmitted, and which applies a pressing force by being brought into contact with the subject at a time of detecting the biological information of the subject,
wherein in a direction from the biological information detecting device to the subject, when a height of the light-transmissive member at a position or in a region corresponding to the first light detector is set to h1 and a height of the light-transmissive member at a position or in a region corresponding to the second light detector is set to h2, h1>h2 is satisfied,
wherein when a distance between the light emitting portion and the first light detector is set to L1 and a distance between the light emitting portion and the second light detector is set to L2, L1 wherein the processing portion performs first body motion noise reduction processing that reduces a body motion noise of a first detection signal which is detected by the first light detector based on a second detection signal which is detected by the second light detector, and
wherein the processing portion calculates biological information based on the first detection signal after the first body motion noise reduction processing.

US Pat. No. 10,244,944

VEIN TRANSILLUMINATION DEVICE USING ORANGE AND RED LIGHT WITH A WHITE EXAM LIGHT

Translite, LLC, Sugar La...

1. An illumination device comprising in combination:a housing having a handle portion at a first end thereof and an illumination portion with an arc-shaped light generating source at a second end thereof, the housing also having a recess at the second end thereof, the recess being composed of a circular central space and an opening, and the arc-shaped light generating source encircles the circular central space of the recess,
a power source within the arc-shaped light generating source substantially contained with the handle portion has at least one user controlled switch on a side edge of the housing, allowing for actuation of the arc-shaped light generating source and switching between a type of illumination, either transillumination or surface illumination, in controlled manner for the selective examination of a user's skin or veins,
the arc-shaped light generating source including a transillumination orange light composed of LEDs having a wavelength in the range of 580-620 nm, a red light composed of LEDs having a wavelength of light in the range of 620-650 nm for side-transillumination of the veins, and a white exam light composed of LEDs for illumination of the surface of the skin,
the illumination portion includes a substantially semicircular shaped area of illumination shaped and dimensioned to encircle the substantially semicircular central area, the arc-shaped light generating source of the illumination portion extending about an arc of approximately 270 degrees and following an edge of the semicircular central area along a lower surface of the housing, and the arc-shaped light generating source includes the transillumination orange light composed of LEDs, the red light composed of LEDs for side-transillumination of the veins and the white exam light composed of LEDs that run along the substantially semicircular shaped area of illumination,
wherein the at least one user controlled switch allowing for actuation of the arc-shaped light generating source of the illumination device further comprises a manual or automatic switch to switch between the orange light, the red light and the white exam light by simply pressing a button or moving the device and wherein a pattern of LEDs comprises a series of sixteen LEDs comprising twelve orange-colored LEDs positioned for emitting orange light outwardly from the lower surface of the housing and four red-colored LEDs positioned for emitting red light outwardly from the lower surface of the housing and intermixed with the series of sixteen LEDs are the white-colored LEDs composed of a series of eight white-colored LEDs symmetrically dispersed amongst the sixteen LEDs, wherein the twelve orange-colored LEDs and the four red-colored LEDs make up a first light source, and the white-colored LEDs make up a distinct second light source the second light source is composed of the eight white-colored LEDs symmetrically dispersed amongst the twelve orange-colored LEDs and four red-colored LEDs, whereby the pattern of LEDs extending about the substantially circular shaped area of illumination begins at a position of approximately 10 o'clock and extends in a counterclockwise direction.

US Pat. No. 10,244,939

FULL-EYE ILLUMINATION OCULAR SURFACE IMAGING OF AN OCULAR TEAR FILM FOR DETERMINING TEAR FILM THICKNESS AND/OR PROVIDING OCULAR TOPOGRAPHY

TearScience, Inc., Morri...

1. An apparatus for imaging an eye, comprising:a control system configured to:
(a) modulate light from a multi-wavelength light source to project a first pattern onto the eye;
(b) receive at an imaging device, at least one first image containing at least one first signal associated with an ocular property of the eye comprising emitted light reflected from at least one first portion of the eye;
(c) modulate light from the multi-wavelength light source to project a second pattern onto the eye, such that at least one second portion of the eye receives the emitted light from the multi-wavelength light source; and
(d) receive at the imaging device, at least one second image containing at least one second signal associated with the ocular property of the eye comprising the emitted light reflected from the at least one second portion of the eye;
wherein:
the at least one first signal is optical wave interference of specularly reflected light from an ocular tear film combined with at least one background signal; and
the control system is configured to receive the at least one first image by being configured to:
capture a first pattern of the specularly reflected light including the at least one background signal from at least one first portion of the ocular tear film in the at least one first image by the imaging device; and
capture a second pattern of the specularly reflected light including the at least one background signal from at least one second portion of the ocular tear film in the at least one second image by the imaging device.

US Pat. No. 10,244,937

IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD

Canon Kabushiki Kaisha, ...

1. An image processing apparatus, comprising:a tomographic image acquiring unit, configured to acquire a plurality of tomographic luminance images obtained by photographing an object at different times, and a plurality of polarization-sensitive tomographic images corresponding to the plurality of tomographic luminance images;
a positioning unit configured to position the acquired plurality of polarization-sensitive tomographic images, by at least deforming at least one of the acquired plurality of polarization-sensitive tomographic images so that correlation of the acquired plurality of tomographic luminance images is greater than a threshold value; and
a generating unit configured to generate a new polarization-sensitive tomographic image, using the plurality of polarization-sensitive tomographic images which are positioned.

US Pat. No. 10,244,936

METHOD AND APPARATUS FOR ENGAGING AND PROVIDING VISION CORRECTION OPTIONS TO PATIENTS FROM A REMOTE LOCATION

1. A patient POD for engaging and providing vision correction support, the patient POD comprising a processor having an input means for collecting patient data; equipment to obtain various ocular measurements and characteristics, including data from a physiology examination, a refractive examination, a topographical examination and a wavefront examination; a transmission medium for providing two-way communication between a patient and an eye care professional to determine options for treatment if required; a display for providing simulations of both the impact of vision correction and how the patient would look with the vision correction means; a device for storing data and generating a patient ID card with the data thereon, and an apparatus for forming a custom lens that resides on or in the eye directly from the ocular measurements and characteristics, the custom lens including targeted sphere power, targeted cylindrical power and axis, targeted diameter, targeted stabilization profiles and targeted thickness profiles, the apparatus being configured to form the custom lens from a lens precursor that resides on or in the eye utilizing a free form technique wherein the surfaces of the custom lens are formed by cross-linking of a reactive mixture, the apparatus comprising a first apparatus for forming a lens precursor, the first apparatus comprising a substrate including an arcuate surface, wherein at least a portion of the substrate includes an optical quality surface and a source of actinic radiation controllable to cure a portion of the reactive mixture from the optical quality surface in a predetermined pattern on a voxel by voxel basis, and a second apparatus for forming a lens based upon the lens precursor, the second apparatus comprising a light source for emitting actinic radiation, a means for focusing the actinic radiation, a mold part comprising a lens forming surface transmissive of sufficient converging light from the means for focusing to comprise actinic radiation, a vessel for containing reactive mixture around the lens forming surface in an amount in excess of an amount required to form the lens precursor, a material removal device operational to remove fluent reactive mixture, a dwelling location where the mold part can be positioned such that flowable chemical residue may flow across the near surface region of the lens precursor and a source of fixing radiation sufficient to fix unreacted and partially reacted monomer forming the lens precursor to form the lens based upon the lens precursor.

US Pat. No. 10,244,932

ENDOSCOPE SYSTEM WITH ANTIFOGGING HEATING OF DISTAL LENS

OLYMPUS CORPORATION, Tok...

1. An endoscope system comprising:a first lens, a part of which is exposed outside of an endoscope;
a second lens disposed on a proximal end side with respect to the first lens;
a first barrel that holds the second lens;
a second barrel that holds the first lens on a distal end side of an inner circumferential surface of the second barrel, and movably holds the first barrel on a proximal end side of the inner circumferential surface;
a coil that is wound on an outer circumferential surface of the second barrel, generates a magnetic field for moving the first barrel, and generates heat for heating the first lens; and
a third barrel that surrounds the second barrel and the coil,
wherein an inner circumferential surface of the third barrel on a distal end side thereof and the outer circumferential surface of the second barrel are fitted to each other, and
a heat insulating space for preventing transmission of the heat from the coil to the third barrel is formed between the inner circumferential surface of the third barrel and an entire outer circumferential surface of the coil.

US Pat. No. 10,244,931

ILLUMINATED OPHTHALMIC INFUSION LINE AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Novartis AG, Basel (CH)

1. An ophthalmic surgical system, comprising:a light source;
a fluid source;
an illuminated infusion line comprising:
an infusion arrangement comprising:
a first flexible elongate tube defining a first lumen;
a second flexible elongate tube defining a second lumen; and
a flow tube coupled to a distal end of the first flexible elongate tube, the flow tube defining a third lumen and comprising a groove on an exterior surface thereof, the first lumen and the third lumen in fluid communication with the fluid source and configured to deliver a fluid from the fluid source to an interior of an eye of a patient during a surgical procedure, and the flow tube being sized to penetrate the eye of the patient and deliver the fluid to the interior of the eye; and
an optical fiber comprising:
a proximal portion disposed in the second lumen of the second elongate tube; and
a distal portion received within the groove of the flow tube,
the optical fiber being in optical communication with the light source and coupled to the infusion arrangement, the optical fiber being configured to transmit light from the light source to illuminate the interior of the eye during the surgical procedure.

US Pat. No. 10,244,927

SPACE-OPTIMIZED VISUALIZATION CATHETER WITH CAMERA TRAIN HOLDER

Cook Medical Technologies...

1. A visualization system for performance of a medical procedure within a patient, the visualization system comprising:an outer sheath extending from a proximal portion to a distal portion;
a camera train holder coupled to and disposed within the outer sheath, the camera train holder holding a visualization sensor and a lens stack, the camera train holder having an inner surface and an opposing, outer surface, wherein the inner surface defines:
a proximal area that holds the visualization sensor; and
a distal area that holds the lens stack; and
a first semi-circular channel longitudinally extending through the distal portion of the outer sheath, wherein the first semi-circular channel distally extends to a semi-circular distal opening of the visualization system;
a second semi-circular channel independent of the first semi-circular channel and longitudinally extending through the distal portion of the outer sheath and alongside the first semi-circular channel, wherein the camera train holder is disposed within the second semi-circular channel,
wherein the outer surface of the camera train holder comprises a semi-circular cross-sectional profile, the outer surface comprising a flat outer surface portion defined by the semi-circular cross-sectional profile; and
wherein a flat outer surface portion of the outer surface of the camera train holder faces a flat side of the first semi-circular channel.

US Pat. No. 10,244,925

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope, comprising:an image pickup portion including an image pickup device;
an optical axis bending optical system including a plurality of prisms for guiding a light beam from an object to a light receiving surface of the image pickup portion;
an operation input member which can be pivoted;
an operation conversion member configured to resolve an input from the operation input member and generate a plurality of outputs; and
a plurality of operation transmission members configured to transmit the plurality of outputs that are outputted from the operation conversion member to a respectively corresponding plurality of movable portions;
wherein:
the operation transmission members includes an image pickup portion interlocking member that rotatably supports the image pickup portion around a longitudinal axis, and prism rotation transmission members configured to rotate the plurality of prisms of the optical axis bending optical system.

US Pat. No. 10,244,922

SINGLE USE LARYNGOSCOPE HANDLE FOR USE IN DUAL COMPONENT LARYNGOSCOPE ASSEMBLY

TRUPHATEK INTERNATIONAL L...

1. A single use laryngoscope handle for use in a dual component laryngoscope assembly including (a) a laryngoscope blade having a spatula and intended for dual snap fit engagement on the laryngoscope handle to dispose the spatula into an operative intubation position generally transverse to the laryngoscope handle, the spatula having a distal spatula end remote from the laryngoscope handle in the operative intubation position and (b) an illumination arrangement including an electrically operated illumination source for selectively providing illumination at the distal spatula end in the operative intubation position, the single use laryngoscope handle having a longitudinal handle axis and comprising:a) an elongated tubular plastic hand grip having a leading hand grip end, a trailing hand grip end and a power source assembly compartment between said leading hand grip end and said trailing hand grip end;
b) a power source assembly for storage in said power source assembly compartment for electrically operating the electrically operated illumination source in the operative intubation position, and
c) a plastic end cap mounted on said trailing hand grip end in a pre-actuated position, said plastic end cap having an upright support member for supporting said power source assembly at said leading hand grip end in said pre-actuated position in an upright handle orientation of the laryngoscope handle with said leading hand grip end above said trailing hand grip end,
said plastic end cap including a transverse end plate and an upright end wall, the transverse end plate having at least one axially extending plastic frangible member extending from the transverse end plate between the upright end wall and the upright support member, the frangible member facing radially outward away from said upright support member for engaging a respective throughgoing aperture formed in a lowermost end of said trailing hand grip end, such that the frangible member protrudes into the throughgoing aperture to abut against the upright end wall in the pre-actuated position, and such that a manual actuation of said end cap from said pre-actuated position breaks said at least one plastic frangible member and detaches said end cap from said trailing hand grip end whereupon said power source assembly readily slides downwardly and outwardly from said trailing hand grip end in said upright handle orientation under gravitational force thereby preventing re-use of said single use laryngoscope handle.

US Pat. No. 10,244,920

HINGE FOR DOORS OF ELECTRICAL HOUSEHOLD APPLIANCES

NUOVA STAR S.p.A., Zola ...

1. A hinge for a door of an electrical household applicance provided with a decorative front panel slidably mounted relative to the door along a direction which is orthogonal to an axis of rotation of the door, the hinge comprising,a first element which is fixable, in use, to a frame of the electrical household appliance, the first element including a guide member which is integral with the first element,
a first pin,
a second element pivoted on the first element via the first pin and which is fixable, in use, to the door so that the door can be opened or closed by tilting relative to the frame of the electrical household appliance,
a tie rod pivoted on the second element and including a first cam profile, the first cam profile engaging with the guide member,
an elastic member operatively coupled to the tie rod for applying, in use, a retaining action on the door during movement of the door from a closed position to an open position,
a kinematic unit configured to impart, to the decorative front panel, a movement relative to the door to determine mutual sliding between the door and the decorative front panel,
wherein the kinematic unit comprises a first body which is connected to the first element, a second body pivoted on the first body and having a longitudinal guide, and a connecting linkage between the first body and the second body, the connecting linkage controlling movement of a bracket which is connectable with the decorative front panel, the bracket being slidable along the longitudinal guide;
a second pin defining a fulcrum of the first body and the second body;
wherein the connecting linkage comprises a first lever and a second lever, the first lever having a first longitudinal end and a second longitudinal end opposite the first longitudinal end, the second lever being pivoted on the first lever and on the second pin;
wherein the first body includes a second cam profile and the first lever includes a follower member for engaging the second cam profile;
wherein the follower member is positioned at the first longitudinal end and the first lever is connected to the bracket at the second longitudinal end.

US Pat. No. 10,244,917

DUSTPAN COVER

1. A domestic cleaning apparatus comprising:a dustpan, a lid, and a fastener;
wherein the fastener attaches the lid to the dustpan;
wherein the lid is a barrier that controls access to the dustpan;
wherein the domestic cleaning apparatus is configured to collect debris;
wherein the dustpan is configured to collect debris;
wherein the lid rotates relative to the dustpan such that the dustpan opens and closes for the collection and disposal of debris;
wherein the dustpan is a containment structure;
wherein the dustpan is a wedge-shaped structure;
wherein the lid controls access to a storage space within the dustpan;
wherein the lid rotates relative to the dustpan;
wherein the fastener is a spring-loaded device;
wherein the fastener attaches the lid to the dustpan such that the lid rotates towards and away from a superior face of a collection bin;
wherein the fastener seals the lid against the superior face of the collection bin;
wherein the dustpan comprises a collection bin and a handle;
wherein the handle attaches to the collection bin;
wherein the collection bin contains the debris;
wherein the collection bin is a hollow containment structure;
wherein the collection bin is a wedge-shaped structure;
wherein the collection bin comprises a first vertical face, a second vertical face, a third vertical face, an inferior face, a superior face, and a wedge cant;
wherein the superior face is an open face;
wherein the first vertical face, the second vertical face, the third vertical face, the inferior face, the superior face combine to form the wedge shape of the containment bin;
wherein the wedge cant is the angle between the inferior face and the superior face;
wherein the first vertical face is a triangularly shaped plate;
wherein the second vertical face is a triangularly shaped plate;
wherein the third vertical face is a rectangular plate;
wherein the inferior face is a rectangular plate;
wherein the superior face is a rectangular plate;
wherein the first vertical face projects perpendicularly away from the inferior face;
wherein the second vertical face projects perpendicularly away from the inferior face;
wherein the third vertical face projects perpendicularly away from the inferior face;
wherein the first vertical face shares its perimeter with the third vertical face, the inferior face, and the superior face;
wherein the second vertical face shares its perimeter with the third vertical face, the inferior face, and the superior face;
wherein the third vertical face shares its perimeter with the first vertical face, the inferior face, and the superior face;
wherein the superior face shares its perimeter with the first vertical face, the second vertical face, the third vertical face, and the inferior face;
wherein the second vertical face is distal from the first vertical face;
wherein the third vertical face is distal from the line formed by the intersection of the inferior face and the superior face;
wherein the inferior face and the superior face are not parallel planar surfaces;
wherein a wedge angle is the acute angle formed between the inferior face and the superior face;
wherein the handle is a shaft;
wherein the handle is used as a grip;
wherein the handle attaches to the third vertical face of the collection bin;
wherein the handle attaches to the third vertical face such that the handle projects away from the intersection of the inferior face and the superior face;
wherein the handle attaches to the third vertical face such that the handle forms a grip cant with the inferior face;
wherein the span of the arc of the grip cant between the handle and the inferior face equals the span of the arc of the wedge cant;
wherein the lid encloses a containment space of the dustpan;
wherein the lid comprises a barrier plate and a lever plate;
wherein the barrier plate attaches to the fastener;
wherein the lever plate attaches to the fastener;
wherein the barrier plate is a plate structure;
wherein the perimeter of the barrier plate is geometrically similar to the perimeter of the superior face of the collection bin;
wherein the span of the perimeter of the barrier plate is greater than the span of the perimeter of the superior face.

US Pat. No. 10,244,915

COVERAGE ROBOTS AND ASSOCIATED CLEANING BINS

iRobot Corporation, Bedf...

1. A coverage robot system comprising:a cleaning bin configured to be received by a cleaning robot;
a bin capacity sensor system comprising:
a signal emitter proximate a first side of an opening in the cleaning bin;
a first signal detector proximate the first side of the opening in the cleaning bin, the first signal detector configured to receive a signal emitted by the signal emitter, the signal emitter and the first signal detector being disposed proximate to one another; and
a second signal detector proximate a second side of the opening in the cleaning bin, the second side opposite the first side, the second signal detector configured to receive a signal emitted by the signal emitter; and
a controller configured to monitor a signal from the first signal detector and the second signal detector and determine a cleaning service requirement, and transmit a third signal having information about the cleaning service requirement.

US Pat. No. 10,244,912

VACUUM CLEANER WITH MOTOR BETWEEN SEPARATION STAGES

Dyson Technology Limited,...

1. A vacuum cleaner comprising a main body and a dirt separator removably attached to the main body, wherein the dirt separator comprises a first dirt-separation stage, a second dirt-separation stage, and a vacuum motor for moving air through the first dirt-separation stage and the second dirt-separation stage, the vacuum motor comprises an impeller driven by an electric motor, the first dirt-separation stage is located upstream of the impeller, and the second dirt-separation stage is located downstream of the impeller, and wherein the first dirt-separation stage comprises a single cyclonic separator, and second dirt-separation stage comprises a plurality of cyclonic separators.

US Pat. No. 10,244,911

SURFACE CLEANING APPARATUS

Omachron Intellectual Pro...

1. A surface cleaning apparatus comprising:(a) an air flow passage extending from a dirty air inlet to a clean air outlet and including a suction motor;
(b) a cyclone bin assembly positioned in the air flow passage and comprising a bin first end, an opposed bin second end axially spaced apart from the bin first end in an axial direction and a cyclone bin assembly sidewall located between the bin first and second ends, the cyclone bin assembly sidewall surrounding a contiguous interior volume and comprising:
i) a first sidewall portion extending at least nearly parallel to the axial direction and having a first width in a lateral direction generally orthogonal to the axial direction;
ii) a second sidewall portion extending at least nearly parallel to the axial direction and having a second width in the lateral direction wherein the second width is narrower than the first width;
iii) a third sidewall portion extending at least nearly parallel to the axial direction and disposed between the first sidewall and the second sidewall portion, the third sidewall portion having a third width in the lateral direction that is greater than the second width;
iv) a first inclined transition portion connecting the first sidewall portion and the second sidewall portion and narrowing from the first width to the second width; and,
v) a second inclined transition portion connecting the second sidewall portion and the third sidewall portion and widening from the second width to the third width.

US Pat. No. 10,244,910

DUST AND ALLERGEN CONTROL FOR SURFACE CLEANING APPARATUS

Omachron Intellectual Pro...

1. A surface cleaning apparatus comprising:a) an air flow path extending from a dirty air inlet to a clean air outlet and comprising a main air treatment member having a dirt collection region having an openable door; and,
b) a main suction motor provided in the air flow path,
wherein the dirt collection region is exposed to sub-atmospheric pressure when the openable door is in an open position, and
wherein the main suction motor is utilized to provide the sub-atmospheric pressure to the dirt collection region.

US Pat. No. 10,244,908

SYSTEMS FOR TRANSPORTING AND COLLECTING WASTE

SIMPLAVATE, Surprise, AZ...

1. A system for transporting and collecting waste, comprising;a waste disposal bay comprising an opening;
a cabinet comprising an open configuration and a closed configuration;
a moveable receptacle associated with the cabinet, the movable receptacle comprising a through hole,
wherein the movable receptacle is disposed within the cabinet at a first position when the cabinet is in the closed configuration, and
wherein the movable receptacle is configured to translocate from the first position to a second position and from the second position to the first position when the cabinet is in the open configuration;
a vacuum system associated with the through hole of the moveable receptacle; and
an attachment mechanism having a seal positioned between the opening of the waste disposal bay and the through hole, wherein the seal is configured to maintain fluid communication between the opening and the vacuum system when the cabinet is in the closed configuration and the movable receptacle is in the first position.

US Pat. No. 10,244,902

BACK SCRUBBER FOR USE WITH A WASHCLOTH

1. A back scrubber for use with a washcloth comprising:an elongate shaft having a proximal end and a distal end;
a frame attached to the distal end of the shaft and defining an inner area over which the washcloth wraps to define a back scrubbing surface;
a plurality of flexible teeth extending from the frame toward the center of the inner area with each tooth terminating at a tip such that the tips of the teeth form an opening through which an excess portion of the washcloth that wraps over the inner area and the frame enters to be in contact with an under side of the back scrubbing surface of the washcloth, wherein the opening defined by the tips of the teeth is sufficiently large to receive the excess portion so as to form a generally convex compliant back scrubbing surface of the washcloth, and wherein when the back scrubbing surface is pushed against the skin, the tips of the teeth move toward each other to grab the excess portion of the washcloth tighter to more securely fix the washcloth in place.

US Pat. No. 10,244,891

KITCHEN APPLIANCE COATED BY DOT METHOD AND METHOD OF PREPARING THE SAME

1. A kitchen appliance coated by a dot method, the kitchen appliance comprising:a primer coating layer formed on a surface of the kitchen appliance, wherein a thickness of the primer coating is in a range of 10 um to 12 um, wherein the primer coating layer comprises 63 wt % to 74 wt % of polyamideimide dissolved in N-methyl-2-pyrrolidone (NMP), 3 wt % to 5 wt % of water, 15 wt % to 18 wt % of a polytetrafluoroethylene (PTFE) dispersion, 2 wt % to 4 wt % of a carbon black dispersion, and 6 wt % to 10 wt % of a silica dispersion;
a dot layer formed in a dot shape on a surface of the primer coating layer by repetitive point spraying a coating solution of dot particles, wherein a thickness of the dot layer is in a range of 130 um to 150 um; and
a top coating layer is further formed on the dot layer, the top coat having a thickness in a range of 8 um to 12 um;
wherein the dot particles are individually adhered to the primer coating layer by the point spraying to form a surface and has an average diameter of 5 um to 10 mm when being adhered to the primer coating layer by the point spraying;
wherein an area ratio of the dot layer to the primer coating layer is in a range of 60% to 98%;
wherein the dot layer is spattered by a point spraying method in which the dot layer is formed by overlapping 0 to 20 layers of the dot particles and various colors of the dot layer are obtained by simultaneously or individually point spraying through a plurality of nozzles respectively including coating solutions of various colors; and
wherein a liquid component of the dot particles point sprayed in a form of a liquid is dried during drying to be separated into the individual dot particle to cause irregularities at an upper end portion of the dot layer in view of the entire dot layer.

US Pat. No. 10,244,887

CAPSULE FOR AN EXTRACTION MATERIAL, METHOD FOR PRODUCING THE CAPSULE, AND DEVICE FOR BREWING COFFEE

QBO COFFEE GMBH, Wallise...

1. A portion capsule, comprising:an outer wall, said outer wall enclosing a closed capsule volume by a plurality of outer wall portions integrally connected to one another;
a separation element, the separation element dividing the closed capsule volume into an extraction material region filled by an extraction material and an empty region not containing any extraction material; and
a plurality of liquid channels, the liquid channels being connected in a liquid tight manner with the separation element and being connected in a liquid tight manner with the outer wall at a liquid channel mouth location;
wherein the separation element comprises a liquid permeable passage between the extraction material region and the liquid channels but is liquid tight between the extraction material region and the empty region;
whereby liquid is capable of flowing between
a liquid channel mouth passage through the outer wall at the liquid channel mouth location,
and an extraction material region passage through the outer wall from the extraction material region at a second location,
substantially without entering the empty region, and
wherein the outer capsule wall is liquid tight at the second location, and wherein the extraction material passage needs to be generated by disrupting the outer capsule wall at second location.

US Pat. No. 10,244,886

BREWING APPARATUS FOR EXTRACTING A PORTION CAPSULE

1. A brewing apparatus for extracting a portion capsule, comprising a first brewing chamber element and a second brewing chamber element, wherein the first or the second brewing chamber element is movable in an axial direction between a loading position, in which the first and the second brewing chamber elements are spaced apart from each other, and an extraction position, in which the first and the second brewing chamber elements form a substantially closed brewing chamber, wherein, upon movement of the first or the second brewing chamber element from the loading position into the extraction position, the portion capsule is first perforated by at least one first perforation means of the first brewing chamber element and then is perforated by at least one second perforation means of the second brewing chamber element, the first brewing chamber element has a perforation element which comprises a base surface and the at least one first perforation means formed on a peripheral region of the base surface in a circumferential direction, the at least one first perforation means has a linear cross section which is bent along a circumference of the base surface to protrude perpendicularly from the peripheral region of the base surface, the at least one first perforation means being positioned at a constant radius about a central point of the base surface, the at least one first perforation means cooperates with an edge region of the portion capsule to ensure a more reliable perforation operation, wherein liquid flows at angles through the portion capsule to increase an interaction distance and interaction time between the liquid and contents of the portion capsule.

US Pat. No. 10,244,884

METHOD AND DEVICE FOR PRODUCING A BEVERAGE

Sestec S.A., Vevey (CH)

1. A method for producing a beverage from a capsule containing at least one beverage ingredient, the method comprising:feeding a first volume of water into the capsule for prewetting the at least one beverage ingredient;
interrupting the flow of water into the capsule for a predetermined waiting time;
feeding a second volume of water into the capsule for extracting the at least one beverage ingredient; and
dispensing the produced beverage; and
wherein a time point of interrupting the flow of water into the capsule is determined by evaluating a measurement signal output by a flow meter that measures the flow of water into the capsule, and wherein the time point is determined at least based on a gradient of a flow rate gradient evaluated from the measurement signal of the flow meter.

US Pat. No. 10,244,874

FOLDOVER FOR LOSS PREVENTION AND IMPROVED MERCHANDISING

Contempo Card Company, P...

1. An anti-theft display hanger for supporting an article, comprising: a first member having an outer surface, an inner surface, a top portion, a bottom portion and a thickness defined between the outer surface and inner surface; a second member having an outer surface, an inner surface, a top portion, a bottom portion and a thickness defined between the outer surface and inner surface, the second member being constructed and arranged to overlay at least a portion of the first member in an assembled position; a gusset disposed between the bottom portion of the first member and the bottom portion of the second member and having one or more dielines wherein said dielines create two flaps when the hanger is assembled and further wherein said flaps contain apertures that line up when the hanger is assembled; a recess in one or both members in which to support an electronic article surveillance sensor, the recess being sized to support the sensor therein and having a depth dependent upon the thickness of the first member such that upon supporting the sensor within the recess, the sensor is planar with or below the inner surface of the first member; an engagement member constructed and arranged to support the hanger on a display; means in which to secure the first member to the second member when assembled; and means to secure said article to said hanger; wherein upon assembling the hanger, the second member overlays the first member so as to conceal the electronic article surveillance sensor, the flaps when folded in and towards each other so that the apertures contained therein allow for the securing means to be threaded through said apertures and thereafter capable of securing said article to said hanger, provided when said article is secured to the hanger said article is unable to move within said hanger.

US Pat. No. 10,244,873

ADJUSTABLE PRODUCT DISPLAY SYSTEM AND METHOD

iSee Store Innovations, L...

1. A system for containing and refrigerating one or more products, the system comprising:a refrigerated compartment including a refrigerating chamber and a transparent door having an interior surface and an exterior surface, wherein the transparent door is configured to be selectively moved between open and closed positions to expose and close the refrigerating chamber, wherein the interior surface is positioned within the refrigerating chamber when the transparent door is in the closed position; and
an adjustable product display system mounted to one of the interior surface or the exterior surface, the adjustable product display system comprising:
a bin assembly having an adjustable length, wherein the bin assembly defines a retaining chamber, wherein the bin assembly comprises a first bin moveably secured to a second bin, wherein the first bin is moveable relative to the second bin to adjust a length of the retaining chamber, wherein the first bin comprises a first retaining track defining a first retaining channel at a first upper edge of a first rear wall and a second retaining track defining a second retaining channel at a first front edge of a first base, wherein the second bin comprises a second upper edge, a second front edge, and a second base, wherein the first retaining track and the second retaining track of the first bin slidably retain the second upper edge and the second front edge of the second bin, wherein the first retraining track and the second retraining track are configured to allow the first bin to linearly translate with respect to the second bin;
at least one product-supporting insert that is configured to be selectively positioned in and removed from the retaining chamber, wherein the at least one product-supporting insert has a first wall, a second wall, a third wall and a fourth wall and two open ends, wherein the first wall has a first retaining interface, wherein the first retaining interface is configured to retain at least one product that is a first size and shape, wherein the second wall has a second retaining interface that differs from the first retaining interface, wherein the second retaining interface is configured to retain at least one second product having a second size and shape that differs from the first size and shape, the third wall has a third retaining interface that differs from the first and second retaining interfaces, wherein the third retaining interface is configured to retain at least one third product having a third size and shape that differs from the first and second sizes and shapes, the fourth wall having a fourth retaining interface that differs from the first, second and third retaining interfaces, wherein the fourth retaining interface is configured to retain at least one fourth product having a fourth size and shape that differs from the first, second, and third sizes and shapes: wherein the at least one product supporting insert is configured to be positioned underneath an upper lip within the retaining chamber between a first orientation that displays the at least one first product, a second orientation that displays the at least one second product, a third orientation that displays the at least one third product, and a fourth orientation that displays the at least one fourth product; and
at least one suction cup assembly that removably mounts the adjustable product display system to the interior surface or the exterior surface, wherein the at least one suction cup assembly is configured to limit the adjustable length of the bin assembly, wherein the at least one suction cup assembly is configured to retain an end of a sign.

US Pat. No. 10,244,871

CUSHION

1. A cushion, including:a first recoverable layer, having a first flow passageway;
a second recoverable layer, having a second flow passageway;
a separation layer, located between the first and second recoverable layers, one of two ends of the separation layer having a passage, the first flow passageway, the passage and the second flow passageway forming a circulation flow passageway, the first and second recoverable layers being connected with the separation layer;
an outer layer, encompassing and being connected with the first recoverable layer, the second recoverable layer and a side portion of the separation layer.

US Pat. No. 10,244,870

GAMING CHAIR

1. A gaming chair comprising:a seat support, a back support, a right arm rest, a left arm rest and a rotating wheeled base extending downward from the seat support;
said seat support having a top surface, a bottom surface, a rear edge, a front edge, a right side edge and a left side edge;
a footrest supported by at least one elongated foot rest support extending from the seat support;
at least one upper mounting bracket secured to the gaming chair in a position that is substantially parallel to the right arm rest and the left arm rest;
said at least one upper mounting bracket having a plurality of attachment points located thereon;
said plurality of attachment points being a plurality of apertures spaced apart along said at least one upper mounting bracket; and
at least one upper support surface attached to the at least one upper mounting bracket via at least one attachment point of the plurality of attachment points located on the at least one upper mounting bracket.

US Pat. No. 10,244,866

MODULAR STORAGE RACK

1. A modular storage rack comprising:a first small flat panel and a second small flat panel, each comprising one flat segment;
a first large flat panel and a second large flat panel, each comprising three flat segments;
each flat segment comprising a slit extending partway through the flat segment, the slit having a slit profile;
the first large flat panel comprising a first outer flat segment, a second middle flat segment, and a third outer flat segment; and
the second large flat panel comprising a fourth outer flat segment, a fifth middle flat segment, and a sixth outer flat segment;
a first small cross panel and a second small cross panel, each comprising one cross segment;
a first large cross panel and a second large cross panel, each comprising three cross segments;
each cross segment comprising:
a first planar portion terminating in a first lip oriented out of a first plane of the first planar portion;
a second planar portion terminating in a second lip oriented out of a second plane of the second planar portion;
the first lip facing the second lip, the first lip and the second lip defining a slot for receiving the flat segment; and
an island joining the first planar portion to the second planar portion, the island disposed in the slot and between the first lip and the second lip, the island having an outer perimeter matching the slit profile, the island configured to be received in the slit;
the first large cross panel comprising a first outer cross segment, a second middle cross segment, and a third outer cross segment; and
the second large cross panel comprising a fourth outer cross segment, a fifth middle cross segment, and a sixth outer cross segment;each given flat segment matingly connected to a corresponding cross segment such that the given flat segment is received in the slot of the corresponding cross segment and the island of the corresponding cross segment is received in the slit of the given flat segment, wherein:the first outer cross segment is matingly connected to the flat segment of the first small flat panel;
the second middle cross segment is matingly connected to the second middle flat segment;
the first outer flat segment is matingly connected to the cross segment of the first small cross panel;
the third outer cross segment is matingly connected to the fourth outer flat segment;
the third outer flat segment is matingly connected to the fourth outer cross segment;
the fifth middle flat segment is matingly connected to the fifth middle cross segment;
the sixth outer cross segment is matingly connected to the flat segment of the second small flat panel; and
the sixth outer flat segment is matingly connected to the cross segment of the second small cross panel.

US Pat. No. 10,244,864

DEVICE AND SYSTEM FOR JOINING OBJECTS

PABensen Pte. Ltd., Sing...

1. A joint assembly comprising:an engagement block having a plurality of insert receiving faces;
each insert receiving face having a slot, and an aperture at a mid-point of the slot;
a plurality of inserts each having a core, at least a pair of ribs projecting from the core, a coupling at an insertion end of the core and a mount at a mounting end of the core;
a coupling pin; and
wherein the engagement block is arranged to receive the inserts, with the ribs received into the slots and the cores received into the apertures, the coupling pin arranged to be inserted into the engagement block and couple with the couplings of the inserts so as to releasably fix the inserts to the engagement block.

US Pat. No. 10,244,863

ADJUSTABLE SHELF

1. A storage apparatus comprising:a shelf having first and second planar members hingeably coupled to each other by a hinge mechanism; and
first and second walls spaced apart from each other, wherein each of the first and second walls have a means for holding the shelf at a location between the first and second walls,
wherein the shelf is configured so that the first and second planar members are pivotable at angles relative to each other about the hinge mechanism for insertion into and removing from the location between the first and second walls, wherein the means for holding the shelf at the location between the first and second walls is configured so that the shelf is positioned at the location substantially perpendicular to the first and second walls, and wherein each of the first and second walls include another means for holding the shelf at another location between the first and second walls, wherein the shelf is configured so that the first and second planar members are pivotable with respect to each other so that distal ends of the first and second planar members disengage with the means for holding the shelf at the location and the shelf is thus configured so it can be moved to the another location.

US Pat. No. 10,244,859

BROOM ATTACHMENT, BROOM ASSEMBLY AND METHOD FOR USE THEREOF

Balais Nomad Inc., Mirab...

1. A broom assembly, comprising:a rotary sweeper assembly including a circular broom mount having a surface and at least one broom section mounted to the broom mount, each of the at least one broom section including a segment holding cleaning bristles;
a broom attachment, comprising:
a plurality of gutter bristles; and
a support member having a retained portion and a retaining portion, the plurality of gutter bristles extending from the retaining portion;
the retained portion being operatively mounted to the surface the broom mount, such that the gutter bristles of the broom attachment extend outwardly relative to the cleaning bristles of the at least one broom section, the broom mount having an axis of rotation that extends substantial perpendicular to the surface of the broom mount;
wherein the gutter bristles are positioned at a greater radial distance away from the axis of rotation of the broom mount than the cleaning bristles of the at least one broom section; and
a broom fastener projecting through the broom mount, the retained portion and the at least one broom section, thereby securing the broom attachment to the broom mount and the at least one broom section.

US Pat. No. 10,244,857

ORAL CARE IMPLEMENT AND FILAMENT FOR THE SAME

Colgate-Palmolive Company...

1. A mechanically tapered filament for an oral care implement, the filament comprising:an elongated shaft terminating in a tip and having a mounting end portion of constant cross section and a tapered end portion;
wherein the tapered end portion has a taper length of 5 mm or more;
wherein the tapered end portion has an areal surface roughness value of at least 0.20; and
wherein the filament has a Nelson Ratio between 0.8 to 1.20.

US Pat. No. 10,244,856

UNIVERSAL PHALANGI GRIP SYSTEM FOR TOOTHBRUSH AND UTENSILS

1. A toothbrush for individuals with impaired hand gripping ability comprises,a handle portion and a brush portion,
said handle portion of unitary construction having an elongated rigid support base,
an integral upstanding flexible segmented finger engagement portion with multiple longitudinally spaced finger engagement openings therein, each of the finger engagement openings having an associated upper opening with a dimension along the length of the handle that is less than the respective figure engagement opening,
intermediate connective web portions between said respective finger engagement openings, upper ends of adjacent web portions defining each respective upper opening,
said brush portion having an elongated support extending longitudinally from said support base, a brush head having a co-mingled bristle pattern extending therefrom.

US Pat. No. 10,244,855

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle extending along a longitudinal axis from a proximal end to a distal end; and
a head having a front surface and an opposite rear surface, the head comprising:
a cantilever connected to and extending longitudinally from the distal end of the handle, the cantilever having a front surface, a rear surface, and a distal end;
a rigid plate having a front surface, a rear surface, a first portion, a second portion, and a distal end, the rear surface of the rigid plate spaced from the front surface of the cantilever by a gap, and the distal end of the rigid plate spaced away from the distal end of the handle along the longitudinal axis; and
a resilient material in the gap flexibly coupling the rigid plate to the cantilever, the resilient material covering, via direct surface contact, an entirety of the rear surface of the rigid plate and an entirety of the front surface of the cantilever;
wherein the first portion of the rigid plate extends longitudinally beyond the distal end of the cantilever and the second portion of the rigid plate overlaps the cantilever, the resilient material extending from the distal end of the cantilever to the distal end of the rigid plate.

US Pat. No. 10,244,851

BAG CARRIER

1. A bag carrier comprised of a carrier and a strap;the strap at a first end and a second end is affixed to a ring;
the strap is bisected by a buckle that adjusts a length of the strap;
the length of the strap sufficient so that when the strap is placed over a shoulder of a user the ring lies adjacent to the user's hip;
the carrier has a frame;
the frame has on a lower side a bag hook;
the frame has on an upper side a handle;
the frame has on a first side a support hook;
the support hook connects to the ring;
a handle on a shopping bag attaches to the bag hook.

US Pat. No. 10,244,848

GROOMING MIRROR

1. A grooming mirror for assisting a user with clipping facial hair, so that hair clippings are captured for disposal without littering a bathroom area, the grooming mirror comprising:a reflective mirror mounted on a housing;
a base attached to and extending from the housing for operatively supporting the reflective mirror for use by the user;
a clippings catching sheet for catching the hair clippings; and
a rigid framework that extends from the base to support the clippings catching sheet beneath the reflective mirror, wherein the rigid framework includes a plurality of rigid spokes that extend outwardly from the base to support the clippings catching sheet beneath the reflective mirror for catching the hair clippings.

US Pat. No. 10,244,833

FOUR-STONE SEAMLESS RADIANT CUT DIAMOND AND METHOD FOR MAKING THE SAME

1. A method of cutting a diamond from a princess cut diamond, said princess cut diamond comprising:a table;
a crown disposed below the table
a girdle disposed beneath the crown, wherein the girdle comprises four facets forming a substantially rectangular shape, wherein the four facets comprise a first facet, a second facet substantially perpendicular to the first facet, a third facet substantially perpendicular to the second facet, and a fourth facet substantially perpendicular to the third facet and substantially perpendicular to the first facet;
a pavilion disposed below the girdle, and
a culet directly below a point substantially at the center of the girdle, wherein the method comprises:
making a cut parallel to the third facet, proceeding from the second facet to the fourth facet, thereby:
removing a portion of the crown and pavilion,
shortening the second facet and the fourth facet into a shortened second facet and a shortened fourth facet, respectively, and
resulting in a first new girdle facet, wherein the first new girdle facet is directly connected to the table;
making a cut parallel to the shortened fourth facet, proceeding from the first new girdle facet to the third facet, thereby:
removing another portion of the crown and the pavilion,
shortening the third facet into a shortened third facet,
shortening the first new girdle facet into a shortened first new girdle facet having a first measurement,
resulting in a second new girdle facet having a second measurement, wherein the second new girdle facet is directly connected to the table, and perpendicular to the shortened first new girdle facet, and
wherein the shortened first new girdle facet and the second new girdle facet meet at a first point;
cutting the pavilion such that the culet is directly under a second point that is within 1% deviation of half the first measurement from the first point and half the second measurement from the first point, and
cutting a radiant facet connecting two of the shortened first new girdle facet, the second new girdle facet, the shortened third girdle facet, and the shortened fourth girdle facet.

US Pat. No. 10,244,822

LACE ROUTING PATTERN OF A LACING SYSTEM FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A lacing system for an article of footwear with a tensioning assembly, the lacing system comprising:a lace having comprising a first lace segment and a second lace segment;
wherein the first lace segment has a first end and a second end, the first end configured to be attached to an upper of the article of footwear on one of a medial side and a lateral side of the upper, and the second end configured to be connected to the tensioning assembly;
wherein the second lace segment has a first end and a second end, the first end configured to be attached to the upper of the article of footwear on one of the medial side and the lateral side of the upper, and the second end configured to be connected to the tensioning assembly; and
a plurality of lacing guides that are made of a closed tubular material, the plurality of lacing guides including at least a first lacing guide and a second lacing guide, the first lacing guide crossing over and overlapping the second lacing guide, the first lace segment extending through the first lacing guide and the second lace segment extending through the second lacing guide, the first lacing guide and the first lace segment together forming a first routing pattern, and the second lacing guide and the second lace segment together forming a second routing pattern;
wherein the lacing guides are positioned in a lacing area, the lacing area configured to extend from a throat opening of the article of footwear in a longitudinal direction towards an area proximate to a forefoot region of the article of footwear and between a medial edge on the medial side of the upper and a lateral edge on the lateral side of the upper;
wherein a total closure distance between the medial edge and the lateral edge of the lacing area according to the first routing pattern is approximately equal to a total closure distance between the medial edge and the lateral edge of the lacing area according to the second routing pattern.

US Pat. No. 10,244,819

APPARATUS AND METHOD FOR SECURING AN UPPER TO A SOLE

NIKE, Inc., Beaverton, O...

1. A manufacturing apparatus for an article of footwear, comprising:first and second pairs of clamps that secure in place a sole of the article of footwear, the first pair of clamps cooperating to secure a ball region of the sole and the second pair of clamps cooperating to secure a heel region of the sole; and
first and second perimeter deforming implements that, when initiated, apply pressure to a bottom surface of the secured sole causing a lateral rim and a medial rim of a perimeter of a top surface of the secured sole to open outwardly from a central longitudinal axis of the sole.

US Pat. No. 10,244,811

SUSPENSION LOCKING TAB

Honeywell International I...

1. A hardhat comprising:a shell having an outer surface and an inner surface;
a suspension comprising a horizontal band that is configured to at least partially encircle a user's head;
a hanger connected to the suspension for securing the suspension to the shell, the hanger further comprising:
a hook at a first lower end of the hanger;
a latching surface located towards a middle of the hanger;
a lever arm at a second upper end of the hanger;
a mount formed on the inner surface of the shell, the mount having a mount platform toward a first lower end of the mount and a ledge surface at a second upper end of the mount;
wherein the hanger is configured to securely engage the mount with the latching surface of the hanger being in frictional engagement with the ledge surface of the mount and the mount platform being in direct facing relation with a surface on the hook, thereby positionally securing the hanger to the shell,
and further wherein the first lower end of the hanger is the lower end thereof when the suspension is secured to the shell and the shell is in an upright position.

US Pat. No. 10,244,805

CONVERTIBLE BIKINI TOP AND APPARATUS FOR CONVERSION OF A BIKINI TOP

1. A method of securing a string bikini, the string bikini having a panel with first and second strings extending outwardly therefrom, the method comprising the steps of:providing a bead having intersecting first and second passageways extending therethrough, said first passageway being perpendicular to said second passageway;
threading said first string through said first passageway of said bead;
threading said second string through said second passageway of said bead such that said first string frictionally engages said second string so as to hold said first string in a position relative to said second string, and such that said first string and said second string engage inner walls of said bead.

US Pat. No. 10,244,803

ATHLETIC SHORTS GARMENT APPARATUS WITH IMPROVED INTERFEMORAL GUSSET AND SURROUNDING MODESTY PANEL

1. An athletic shorts garment apparatus with improved interfemoral gusset and surrounding modesty panel comprising:a) a waistband complex having an anterior face connected to a posterior face along a left waistband seam and a right waistband seam, said waistband complex having a top shorts complex seam edge and a bottom shorts complex seam edge;
b) a shorts garment complex having a left leg structure and a right leg structure connected along a central anterior seam and a central posterior seam, said shorts garment complex having a top shorts garment complex seam edge, a left leg structure bottom shorts garment seam edge and a right leg structure bottom shorts garment seam edge, said left leg structure having an anterior left interfemoral gusset seam edge and a posterior left interfemoral gusset seam edge, said right leg structure having an anterior right interfemoral gusset seam edge and a posterior right interfemoral gusset seam edge, said top shorts garment complex seam edge is attached to the bottom shorts complex seam edge of the waistband complex;
c) an improved interfemoral gusset comprising two continuous panels of a same shape in a double-layered arrangement connected at boundary edges, wherein the improved interfemoral gusset is attached to the shorts garment complex along the anterior right interfemoral gusset seam edge, the posterior right interfemoral gusset seam edge, the anterior left interfemoral gusset seam edge, and the posterior left interfemoral gusset seam edge, said improved interfemoral gusset having an oblong hexagonal shape;
d) a modesty panel having a top modesty panel seam edge and a bottom modesty panel hem edge, where said top modesty panel seam edge is attached to the bottom waistband complex seam edge;
e) an angled left leg cuff piece having a fold forming a dual layer cuff attached to the left leg structure bottom shorts garment seam edge and attached to the improved interfemoral gusset and having a diameter at a bottommost edge that is smaller than a diameter at a topmost edge of the angled left leg cuff piece that is attached to the left leg structure bottom shorts garment seam edge; and
f) an angled right leg cuff piece having a fold forming a dual layer cuff attached to the right leg structure bottom shorts garment seam edge and attached to the improved interfemoral gusset and having a diameter at a bottommost edge that is smaller than a diameter at a topmost edge of the angled right leg cuff piece that is attached to the right leg structure bottom shorts garment seam edge.

US Pat. No. 10,244,798

UNDERGARMENT AND GUSSET THEREFOR

The Underwares Group, LLC...

1. A lower body garment comprising:a body including a protected portion configured to cover a protected region of a wearer and an unprotected portion configured to cover an unprotected region of the wearer outside of the protected region of the wearer, the body having a front face and a rear face opposite the front face, and a crotch portion extending between the front face of the body and the rear face of the body;
a gusset located on the body and configured to substantially cover the protected region of the wearer and at least a portion of the front face, the crotch portion, and the rear face, the gusset comprising:
two side edges, a top front edge, and a rear edge that collectively form an outer edge that defines an outline of the gusset, the top front edge being within the front face of the body, the gusset extending to the rear edge located at the rear face of the body;
a transverse axis bisects an elongated length of the gusset, wherein a portion of the gusset bound by the transverse axis, a first portion of each of the side edges and the top front edge defines a front area of the gusset, and a portion of the gusset bound by the transverse axis, a second portion of each of the side edges and the rear edge defines a rear area of the gusset, the front area and the rear area both extending from the crotch portion and to the outer edge; and
the front area of the gusset being larger than the rear area of the gusset and wherein the rear area of the gusset is located near the rear face of the body, the front area of the gusset is located near the front face of the body, and the rear face of the body includes more surface area than the front face of the body.

US Pat. No. 10,244,797

SHIRT WITH FLIP-UP FRONT PANEL

LOGAN FLIP UP LIMITED, M...

1. A garment to be worn by a person, comprising:a base garment comprising front and back panels connected to each other to extend, when worn, respectively in front of and behind a torso of the person, the front and back panels defining an upper collar opening from which the head of the person can protrude and arm openings from which the arms of a person can extend;
a flip up front panel secured to the base garment and having a flip up region movable between a lowered position in which the flip up region covers at least a portion of the front panel to a raised position in which the portion of the front panel is exposed and the flip up region covers a face of the person, the flip up panel having an upper edge portion that is secured to the front panel around a front perimeter of the upper collar opening; and
the flip up region being formed from see-through mesh that obscures the portion of the front panel covered thereby when in the lowered position, and obscures the face of the person covered thereby when in the raised position while permitting the person to see through the mesh.

US Pat. No. 10,244,781

REFRIGERATED BLANKET FOR COLD PRODUCT TRANSPORT

Walmart Apollo, LLC, Ben...

1. A flexible cooling blanket comprising:a cooling layer assembly comprising:
a first fabric sheet;
a second fabric sheet, the second fabric sheet being operatively coupled to the first fabric sheet along a first folding seam;
a first set of rigid cooling coils disposed between the first and second fabric sheets on a first side of the first folding seam;
a second set of rigid cooling coils disposed between the first and second fabric sheets on a second side of the first folding seam; and
a first flexible tube connecting the first set of rigid cooling coils and the second set of rigid cooling coils, the first flexible tube extending across the first folding seam from the first side of the first folding seam to the second side of the first folding seam;
a heat dissipating layer assembly comprising:
a third fabric sheet;
a fourth fabric sheet, the fourth fabric sheeting being operatively coupled to the third fabric sheet along a second folding seam;
a first set of rigid heat dissipating coils disposed between the third and fourth fabric sheets on a first side of the second folding seam;
a second set of rigid heat dissipating coils disposed between the third and fourth fabric sheets on a second side of the second folding seam; and
a second flexible tube connecting the first set of rigid heat dissipating coils and the second set of rigid heat dissipating coils, the second flexible tube extending across the second folding seam from the first side of the second folding seam to the second side of the second folding seam;wherein the cooling layer assembly and the heat dissipating layer assembly are operatively connected, and the second fabric sheet of the cooling layer assembly is disposed adjacent to the third fabric sheet of the heat dissipating layer assembly; anda compressor operatively connected to the cooling layer assembly.

US Pat. No. 10,244,780

FOOD PRESERVATION SYSTEM

YUAN ZE UNIVERSITY, Taoy...

1. A food preservation system, comprising:a storage cabinet for storing foods;
an electrolytic gas generator in fluid communication with the storage cabinet, wherein the electrolytic gas generator outputs a first gas and a second gas to the storage cabinet for preserving the foods;
a gas detector disposed in the storage cabinet for detecting a gas in the storage cabinet and obtaining a gas concentration information, wherein the gas concentration information comprises a first gas concentration and a second gas concentration; and
a control unit electrically connected to the electrolytic gas generator and the gas detector, wherein the control unit adjusts a voltage value of the electrolytic gas generator according to the gas concentration information, and the control unit controls the type of gases generated by the electrolytic gas generator by adjusting the voltage value, and adjusts the concentrations of the first gas and the second gas in the storage cabinet.

US Pat. No. 10,244,778

METHOD FOR MONITORING COOKING IN AN OVEN APPLIANCE

Haier US Appliance Soluti...

1. A method for monitoring cooking in an oven appliance, comprising:receiving a food item indication at a controller of the oven appliance;
heating a food item within a cooking chamber of the oven appliance, the food item indication corresponding to a type of the food article within the cooking chamber;
drawing cooking vapors or gases from the cooking chamber to a fluid analysis assembly of the oven appliance;
opening a control valve of the fluid analysis assembly in order to mix ambient air about the fluid analysis assembly with the cooking vapors or gases from the cooking chamber, the control valve configured for adjusting ambient air flow in response to the food item indication;
determining a cooking status of the food item within the cooking chamber with the controller of the oven appliance based upon a response pattern of a plurality of fluid sensors of the fluid analysis assembly to the mixture of ambient air and cooking vapors or gases;
exposing the plurality of fluid sensors of the fluid analysis assembly to the mixture of ambient air and cooking vapors or gases, each fluid sensor of the plurality of fluid sensors generating a respective signal during said step of exposing, the respective signal from each fluid sensor of the plurality of fluid sensors corresponding to a different gas, vapor or combination of gases and vapors in the cooking vapors or gases;
establishing the response pattern of the plurality of fluid sensors with a multivariate machine or statistical learning model at the controller of the oven appliance, the multivariate machine or statistical learning model comprising a linear discriminant analysis model, a partial least squares discriminant analysis model or a support vector machine; and
activating an alert with the controller of the oven appliance when the cooking status of the food item within the cooking chamber is a done cooking status.

US Pat. No. 10,244,775

DEVICE AND METHOD FOR DOSING CRYOGENIC LIQUID

Smitten Ventures, Inc., ...

1. A system comprising:a container mount;
a container having a bottom and sides configured to hold ingredients, the container configured to attach to the container mount;
a coolant dosing system configured to provide a controlled amount of coolant to the ingredients in the container; and
first and second beaters configured to mix the ingredients in the container, each of the first and second beaters configured to scrape the ingredients from a surface of the other of the first and second beaters and configured to scrape the ingredients from the sides and the bottom of the container, the first and second beaters being disposed to pass within a distance of each other, the distance being sufficient to cause the first and second beaters to scrape the ingredients from the surface of the other of the first and second beaters.

US Pat. No. 10,244,773

COTTON CANDY PREPARING DEVICE

AGATSUMA CO., LTD, Tokyo...

1. A cotton candy preparing device, comprising:a rotary pot that is formed of a pot upper portion and a pot bottom portion,
wherein the pot upper portion has a loading port at an upper end thereof and a tubular inner wall below the loading port,
wherein a lower end of the tubular inner wall has a conically shaped expanded inclined portion that expands downwards, and a plurality of plate-shaped ribs are provided on the conically shaped expanded inclined portion so as to project towards a center of the rotary pot,
wherein lower ends of the plate-shaped ribs contact a disc-shaped heating plate provided on a center of an upper end of the pot bottom portion or forms a slight gap between the disc-shaped heating plate and the plurality of plate-shaped ribs,
wherein a ring member is provided on an outer circumference of a lower end of the conically shaped expanded inclined portion at a lower end of the pot upper portion,
wherein the ring member has a bore diameter such that an inner circumference of the ring member overlaps a circumferential edge of the disc-shaped heating plate,
wherein the ring member includes a plurality of first expanded portions that are formed as cutouts in the ring member each extending radially outwards in a fan shape from an inner edge of the bore diameter,
wherein the plurality of first expanded portions each include a second expanded portion that is formed as a cutout in the ring member further radially outward into a fan shape from the bore diameter, and
wherein an interior space and an outer circumferential exterior portion of the rotary pot are allowed to communicate with each other by way of a gap that is formed in an upper surface of the ring member from an outer circumferential end of each second expanded portion.

US Pat. No. 10,244,766

SYSTEM, DEVICE, AND METHOD FOR OVEN TEMPERATURE CONTROL IN TORTILLA AND TORTILLA CHIP PRODUCTION

1. A heat controlled oven system, comprising:a) at least one oven level, comprising:
an oven belt, which is configured to transport food products that are positioned on the oven belt; and
at least one gas burner, which is configured to bake the food products that are transported on the oven belt; and
b) a heat control unit, which is configured to control the at least one gas burner, in order to control a baking temperature of the at least one oven level, wherein the heat control unit is configured to calculate an estimated heat demand to adjust to a temperature set point, using a heat model of the at least one oven level, wherein the heat control unit further comprises:
a processor;
a non-transitory memory;
an input/output component;
a heat modeler, which is configured to store the heat model for the at least one oven level;
a heat manager, which is configured to calculate the estimated heat demand to adjust the at least one oven level to the temperature set point; and
a feedback controller, which is configured to execute a control loop feedback algorithm to calculate an optimized heat demand based on the estimated heat demand;
wherein the heat model further comprises a heat capacity, a general heat loss, a product heat loss, and a heat required to hold a current temperature;
wherein the heat manager calculates the estimated heat demand as the sum of the general heat loss, the product heat loss, and a heat required to change a current temperature.

US Pat. No. 10,244,760

OPHTHALMIC AND CONTACT LENS SOLUTIONS CONTAINING SIMPLE SACCHARIDES AS PRESERVATIVE ENHANCERS

FXS VENTURES, LLC, Salem...

1. A method for providing an ophthalmic solution comprising:contacting an eye with a single-part solution comprising 0.00001 to 10.0 weight percent of a simple saccharide selected from a group consisting of an aldose, a triose, a tetrose, a pentose, a hextose, and a heptose;
at least 0.00001 weight percent of a preservative with a structure given by:

wherein n is a number between 1 and 500 and Z is a divalent bridging group; and
wherein the concentration of chloride in said solution is not more than 0.2 percent by weight.

US Pat. No. 10,244,756

FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}(THIO)CARBOXAMIDES

Bayer CropScience Aktieng...

1. A compound of formula (I)wherein:A is a carbo-linked, unsaturated or partially saturated, 5-membered heterocyclyl group that can be substituted by up to four groups R that can be the same or different, provided that A is not a 3-(dihalogenomethyl)-5-halogeno-1-methyl-1H-pyrazol-4-yl group wherein the halogeno atoms are independently a fluoro or chloro atom;
T is O or S;
n is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3, 4, 5 or 6;
p is 1, 2, 3, 4 or 5;
Z1 is a non-substituted C3-C7-cycloalkyl or a C3-C7-cycloalkyl substituted by up to 10 atoms or groups that can be the same or different and that can be selected in the list consisting of halogen atoms, cyano, C1-C8-alkyl, C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkylaminocarbonyl and di-C1-C8-alkylaminocarbonyl;
Z2 and Z3 are independently a hydrogen atom; substituted or non-substituted C1-C8-alkyl; substituted or non-substituted C2-C8-alkenyl; substituted or non-substituted C2-C8-alkynyl; cyano; isonitrile; nitro; a halogen atom; substituted or non-substituted C1-C8-alkoxy; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C2-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; substituted or non-substituted C1-C8-alkylsulfanyl; substituted or non-substituted C1-C8-alkylsulfonyl; substituted or non-substituted C1-C8-alkylsulfinyl; amino; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C1-C8-alkoxycarbonyl; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; or substituted or non-substituted N—C1-C8-alkyl-C1-C8-alkoxy-carbamoyl; or
Z2 and Z3 together with the carbon atom to which they are linked can form a substituted or non-substituted C3-C7-cycloalkyl;
Z4 is a halogen atom; hydroxy; cyano; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; formyl; substituted or non-substituted C1-C8-alkylcarbonyl; carboxy; or substituted or non-substituted C1-C8-alkoxycarbonyl;
B1 is a carbo-linked unsaturated, monocyclic or fused bicyclic 5-, 6-, 8-, 9-, 10-membered heterocyclyl ring comprising from 1 up to 4 heteroatoms selected in the list consisting of N, O, S; wherein the dotted line between the two adjacent carbons is a single bond, a double bond or an aromatic bond, with the proviso that B1 is not a 1,3-benzodioxolyl group;
each W is independently a halogen atom; nitro; cyano; isonitrile; hydroxy; amino; sulfanyl; pentafluoro-?6-sulfanyl; formyl; formyloxy; formylamino; substituted or non-substituted (hydroxyimino)-C1-C8-alkyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkenyloxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkynyloxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; carboxy; carbamoyl; N-hydroxycarbamoyl; carbamate; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; C2-C8-halogenoalkenyloxy having 1 to 9 halogen atoms; substituted or non-substituted C3-C8-alkynyloxy; C2-C8-halogenoalkynyloxy having 1 to 9 halogen atoms; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C1-C8-alkyl; substituted or non-substituted C4-C7-cycloalkenyl; C4-C7-halogenocycloalkenyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkenyl; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkynyl; substituted or non-substituted bicyclo[2.2.1]heptanyl; substituted or non-substituted bicyclo[2.2.1]heptenyl; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonyloxy; C1-C8-halogenoalkylcarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonylamino C1-C8-halogenoalkylcarbonylamino having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkyloxycarbonyloxy C1-C8-halogenoalkoxycarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; substituted or non-substituted C1-C8-alkylaminocarbonyloxy; substituted or non-substituted di-C1-C8-alkylaminocarbonyloxy; substituted or non-substituted N—(C1-C8-alkyl)hydroxy carbamoyl; substituted or non-substituted C1-C8-alkoxycarbamoyl; substituted or non-substituted N—(C1-C8-alkyl)-C1-C8-alkoxycarbamoyl; aryl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyl that can be substituted by up to 6 groups Q which can be the same or different; C2-C8-arylalkenyl that can be substituted by up to 6 groups Q which can be the same or different; C2-C8-arylalkynyl that can be substituted by up to 6 groups Q which can be the same or different; aryloxy that can be substituted by up to 6 groups Q which can be the same or different; arylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; arylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyloxy that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-heteroarylalkyl that can be substituted by up to 6 groups Q which can be the same or different; heteroaryl which can be substituted by up to 4 groups Q; or heteroaryloxy which can be substituted by up to 4 groups Q;
each Y is independently a halogen atom; C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; or substituted or non-substituted C1-C8-alkoxycarbonyl;
each Q is independently a halogen atom, cyano, nitro, substituted or non-substituted C1-C8-alkyl, C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted C1-C8-alkylsulfanyl, C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted tri(C1-C8)alkylsilyl, substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl, substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl, or substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; and
R is independently hydrogen atom; halogen atom; nitro; cyano; hydroxy; amino; sulfanyl; pentafluoro-?6-sulfanyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C3-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; phenoxy; phenylsulfanyl; phenylamino; benzyloxy; benzylsulfanyl; or benzylamino,or a salt, an N-oxide, a metal complex, a metalloid complex, an optically active isomer, or a geometric isomer thereof.

US Pat. No. 10,244,749

MICROMANIPULATION AND STORAGE APPARATUS AND METHODS

Genea IP Holdings Pty Lim...

1. A method of cryopreservation of biological material using an apparatus including a vessel having a reservoir, wherein said vessel has a channel formed in a portion of said reservoir, said channel including an intermediate restriction dimensioned to resist passage of said biological material but allow passage of liquid treatment solutions, and said channel including a first sub-reservoir at a first end of said restriction and a second sub-reservoir at a second end of said restriction, the method comprisin the steps of:introducing said biological material into the first sub-reservoir of said vessel;
irrigating said biological material with a series of vitrification solutions introduced into the first sub-reservoir and removed from the second sub-reservoir;
removing the vitrification solutions from the second sub-reservoir, leaving a residual volume of liquid surrounding the biological material that is sufficiently small for vitrification; and
vitrifying the biological material and the residual volume of liquid surrounding the biological material within the vessel.

US Pat. No. 10,244,748

METHOD FOR MOTION CONTROL AND/OR REGULATION OF AN AGRICULTURAL DISTRIBUTION DEVICE

HORSCH LEEB Application S...

1. A method for the position-controlled guidance of at least two pivotably movable cantilevered arms of an agricultural distribution machine over a ground surface, wherein the at least two pivotably movable cantilevered arms are each positioned adjacent a middle part, and wherein a relative position of the at least two pivotably movable cantilevered arms in relation to the ground surface is detected and a symmetrical realignment of the at least two pivotably movable cantilevered arms and/or of the distribution machine is carried out through autonomous regulation based on the detected relative position in response to a pivoting motion in relation to the ground surface, wherein the autonomous regulation may be overridden by way of manual control comprising a manually specifiable regulation parameter for at least one of the at least two pivotably movable cantilevered arms, which manually specifiable regulation parameter at least temporarily lifts or pivots at least one of the at least two pivotably movable cantilevered arms, wherein the autonomous regulation is temporarily interrupted by way of manual control for at least one of the at least two pivotably movable cantilevered arms, wherein a positioning of the at least one of the at least two pivotably movable cantilevered arms is carried out in a manually controlled manner during the interruption,wherein at least one angle potentiometer for the detection of an angular position between the middle part and the at least two pivotably movable cantilevered arms is arranged between the middle part and at least one of the at least two pivotably movable cantilevered arms, wherein an actuator that is assigned to an oppositely positioned cantilevered arm is controlled on the basis of the angular position detected by the at least one angle potentiometer;
and wherein a desired position for the at least one of the at least two pivotably movable cantilevered arms in relation to the ground surface is specified in a manually controlled manner during the interruption of the autonomous regulation and is subsequently maintained in a regulated manner over a definable time interval or until termination of manual control.

US Pat. No. 10,244,747

APPARATUS AND METHOD FOR DISCHARGING LIQUID AND/OR SOLID ACTIVE SUBSTANCES

1. An apparatus for spreading liquid and/or solid active agents, comprising:a carrier vehicle;
at least one spray boom arranged pivotably about at least one pivot axis; at least one sensor arrangement for detecting an angular velocity and/or an angular position of the spray boom about the pivot axis in relation to a reference plane and/or in relation to a ground surface;
a control unit operable to process output signals of the at least one sensor arrangement and to generate control signals, wherein the control unit influences or controls, the angular position and/or the angular velocity by at least two coupled control loops;
at least one actuator influencing the present angular position of the spray boom about the pivot axis based in response to control signals from the control unit;
wherein a desired value and/or a desired torque for the at least one actuator is generatable from the output signals of the at least one sensor arrangement by the control unit in an outer control loop;
wherein an actual torque, which moves and/or influences the spray boom, and/or an actual value, which is based on actuator deflections and/or on control signals from the at least one actuator, is detectable in an inner control loop and is used for generating a correction value for achieving the desired torque and/or the desired value; and
wherein the inner control loop takes into account further sensor data comprising an adjustment torque which is induced by the actuator into the spray boom and which is measured or is derived from the interaction of the actuator with the spray boom, and wherein the further sensor data are obtained in immediate connection with control signals of the at least one actuator and/or its detected interaction with the movably suspended spray boom.

US Pat. No. 10,244,745

CHUMMING DEVICE

1. A chumming device for bait, comprising:a shaft, said shaft having a first end located opposite a second end, said shaft having a curvature, said first end of said shaft having a plurality of bores, said plurality of bores each have different sized diameters, said plurality of bores are arranged in an ascending diameter size from said first end of said shaft toward said head, whereby, the diameter of each bore increases in size traveling toward the head and is configured to allow flexibility of said chumming device when launching bait from said chumming device, a first bore has a first diameter length, a second bore has a second diameter length, a third bore has a third diameter length, said first diameter length of said first bore is a length greater than said second diameter length of said second bore, said second diameter length of said second bore is a length greater than said third diameter length of said third bore;
a head, said head is connected to said first end of said shaft, said head having a plurality of openings, said plurality of openings are configured to allow water flow while scooping bait from a live well, said head having a top portion, said top portion is configured to launch said bait from said head, said head having a lower portion, said lower portion of said head forming a chamber, said chamber having a chamber opening, said chamber opening having a size great enough to receive said bait, said chamber is configured to retain said bait;
said chamber having a first side wall located opposite a second side wall, said first side wall and said second side wall having said plurality of openings located thereon, said first side wall of said chamber having a first recess bordering said chamber opening and said second side wall of said chamber having a second recess bordering said chamber opening, said chamber having a lip located opposite a protruding structure, said lip and said protruding structure having said plurality of openings located thereon, said lip extends up from said first end of said shaft, said lip is located between said recess of said first sidewall and said recess of said second sidewall, said lip extends beyond said recess of said first sidewall and said recess of said second sidewall, said lip does not extend beyond an end of said protruding structure, said protruding structure extending beyond said chamber, said protruding structure is configured to align said bait to be launched in a direction by a force of a user; and,
a handle, said handle is connected to said second end of said shaft, said secondary end of said shaft having an anchoring recess located in an opposite direction of said chamber opening, said anchoring recess is located on an end of said handle, said anchoring recess is configured to interlock with a rod holder.

US Pat. No. 10,244,744

GEAR MECHANISM FOR A FISHING REEL

Shimano Inc., Osaka (JP)...

1. A gear mechanism for a fishing reel, comprising:a drive gear having a gear with a prescribed diameter and a drive gear shaft configured to be rotated together with the gear and having a smaller dimension than the prescribed diameter of the gear;
a handle configured to rotate with the drive gear shaft, and comprising a handle arm extending in a direction that axially intersects the drive gear shaft;
a vibration damper disposed between the drive gear shaft and the handle, and configured to dampen transmission of vibration of the drive gear;
a first transmitting member non-rotatably coupled to the handle arm and having an engagement portion; and
a second transmitting member configured to transmit rotation of the handle to the drive gear shaft,
the vibration damper elastically deformable, engaging an engagement portion of the first transmitting member, and being an elastic material with a lower rigidity than the first transmitting member,
the second transmitting member having a higher rigidity than the vibration damper and configured to engage the engagement portion of the first transmitting member after the vibration damper has been elastically deformed by a prescribed amount to transmit rotation of the handle to the drive gear shaft,
the engagement portion of the first transmitting member having at least one pawl receiving portion,
the vibration damper comprising an elastic pawl configured to engage the at least one pawl receiving portion,
the second transmitting member comprising a transmission pawl having a circumferential width that is narrower than a circumferential width of the elastic pawl of the vibration damper, and
the transmission pawl configured to engage the pawl receiving portion after the elastic pawl of the vibration damper has been elastically deformed by a prescribed amount.

US Pat. No. 10,244,742

FISHING HOOK AND COVER

1. A fishing hook and cover comprising:a fishing hook rotatably engaged with respect to the cover in order to hide the fishing hook inside of the cover when not in use, and conversely extend from said cover when the fishing hook is in use;
wherein the fishing hook is attached via a hook hinge to the cover;
wherein the cover is further defined with a first cover member and a second cover member;
wherein the first cover member and the second cover member collectively form a cylindrically-shaped object;
wherein the cover is further defined with an interior;
 wherein the first cover member is further defined with a first interior surface;
wherein the second cover member is further defined with a second interior surface;
wherein the first interior surface includes a hook hinge thereon;
wherein the hook hinge attaches to the fishing hook;
wherein the cover is further defined with a first proximal end and a second distal end; wherein the first proximal end includes a first opening
wherein the second distal end includes a second opening;
wherein the first opening is formed from both the first cover member as well as the second cover member;
wherein the second opening is formed from both the first cover member as well as the second cover member;
wherein the hook hinge is located adjacent to the second distal end;
wherein the hook hinge attaches to a lateral hook member of the fishing hook;
wherein the fishing hook includes the lateral hook member in order to enable the fishing hook to rotate about a horizontal axis;
wherein the rotation of the fishing hook about the horizontal axis, and with respect to the hook hinge enables the fishing hook to rotate out of the cover as well as into the interior of the cover;
wherein the hook hinge enables the fishing hook to be concealed within the cover when the fishing hook is not in use;
wherein the first cover member and the second cover member are attached to one another via a cylinder hinge;
wherein the cylinder hinge is attached to a third edge of the first cover member as well as a fourth edge of the second cover member.

US Pat. No. 10,244,736

SYSTEM AND METHOD FOR AUTOMATICALLY DETERMINING ANIMAL POSITION AND ANIMAL ACTIVITY

Lely Patent N.V., Maassl...

1. A method for automatically monitoring activity of an animal in a system for housing freely moving animals comprising a plurality of animal ID stations, the method comprising the steps ofa) recording a first visit of the animal at a first of the animal ID stations;
b) recording a subsequent second visit of the animal at a second of the animal ID stations;
c) determining a first distance between the first animal ID station at the first visit and the second animal ID station at the second visit, and
d) determining a distance covered by the animal on the basis of the first distance.

US Pat. No. 10,244,735

PET TREAT DELIVERY SYSTEMS

Starmark Pet Products, In...

1. An animal treat delivery system, comprising:an elongated body formed of an animal digestible material, said elongated body having an exterior surface and an interior surface defining an interior cavity extending along a longest dimension of the elongated body and terminating at an opening, wherein the interior surface includes a plurality of projections extending along the longest dimension of the elongated body and projecting from the interior surface into the interior cavity and terminating at free ends spaced apart from one another by at least at least an interior dimension; and
a plurality of discrete animal digestible treats disposed within the interior cavity of the elongated body, wherein:
the plurality of discrete animal digestible treats all have a first dimension less than the interior dimension;
one or more first treats among the plurality of discrete animal digestible treats are installed within the interior cavity in a first orientation such that the first treats easily slide along the interior cavity between the free ends of the plurality of projections; and
one or more second treats among of the plurality of discrete animal digestible treats have a second dimension fitting with interference fit in the interior dimension, and wherein the second treats are wedged between the free ends of the plurality of projections in a second orientation different from the first orientation, such that the one or more second treats temporarily retain the one or more first treats within the interior cavity and temporarily prevent the one or more first treats from sliding out the opening.

US Pat. No. 10,244,733

ADAPTABLE FENCE EXTENSION ASSEMBLY

1. An adaptable fence extension assembly, the assembly comprising:an arc-shaped member, the arc-shaped member defined by a top end, a middle section, and a base end, the base end comprising a longitudinal slot, the longitudinal slot disposed along the length of the base end,
the top end and the middle section of the arc-shaped member having a continuous longitudinal curvature,
the arc-shaped member further defined by a concave side inside the curvature and coextensive with the top end and the middle section and a convex side outside the curvature and coextensive with the top end and the middle section, the concave side comprising at least one U-shaped cavity, the at least one U-shaped cavity defined by an inlet and a cavity terminus, the cavity terminus configured generally narrower than the inlet,
the arc-shaped member further defined by an interior channel, the interior channel longitudinally curved along its length,
the arc-shaped member configured to at least partially insulate electrical current;
at least one tine, the at least one tine disposed at the base end of the arc-shaped member, the at least one tine defined by at least one notch; and
a spine, the spine disposed along the length of the interior channel of the arc-shaped member, the spine configured to enhance the structural integrity of the arc-shaped member.

US Pat. No. 10,244,684

RECTANGULAR BALER WITH IMPROVED STUFFER MECHANISM

CNH Industrial America LL...

1. A rectangular baler comprising:a baling chamber;
a plunger reciprocally mounted in the baling chamber for compressing crop material;
an intake duct for accumulating crop material before transfer into the baling chamber;
a pick-up mechanism for picking up crop material and introducing the crop material into the intake duct; and
a stuffer mechanism configured to selectively execute a packer stroke to advance crop material partially along the intake duct and a stuffer stroke to transfer the crop material accumulated in the intake duct into the baling chamber, the stuffer mechanism comprising two stuffer assemblies at each side of the baler and a tine bar extending between the two stuffer assemblies, and at least one of the two stuffer assemblies comprising:
a first stuffer arm connected at a first pivot point to a first crank arm of a first drive mechanism;
a second stuffer arm connected at a second pivot point to a second crank arm or disc of a second drive mechanism; and
a coupling plate pivotally mounted around a stationary pivot point, the coupling plate coupling the first stuffer arm with the second stuffer arm, wherein the coupling plate is coupled to the first stuffer arm through a connection configured to allow a predetermined limited movement of the first stuffer arm with respect to the coupling plate, and wherein the coupling plate comprises a top corner and a bottom corner,
wherein the second stuffer arm is pivotally connected to the coupling plate at a pivot point located between the top and bottom corners of the coupling plate, and
wherein the tine bar is connected to the first stuffer arm.

US Pat. No. 10,244,680

AUTOMATIC CALIBRATION SYSTEM FOR HEADER HEIGHT CONTROLLER WITH OPERATOR FEEDBACK

Headsight, Inc., Bremen,...

1. A method of calibrating a header height controller, the header height controller comprising processing circuitry capable of receiving output signals from a plurality of height sensors mounted to a header, the output signals variable in magnitude with respect to changes in height of the header relative to a surface, the header height controller responsive to the output signals from the plurality of height sensors, the method comprising the steps of:moving the header through a range of motion relative to a surface;
as the header moves through the range of motion, receiving and storing at predetermined sampling intervals the output signal magnitudes for each of the plurality of height sensors;
defining a Set Point C Magnitude (“SPCM”) for each of the plurality of height sensors, wherein the SPCM is the magnitude of the output signal when the header is at a lowest point of the range of motion;
defining a Set Point A Magnitude (“SPAM”) for each of the plurality of height sensors, wherein the SPAM is the magnitude of the output signal at a predetermined elevation above the lowest point of the range of motion;
identifying anomalies between the output signal magnitudes at predefined points of the sampling intervals of each of the plurality of height sensors.

US Pat. No. 10,244,678

BLADE GUARD FOR A ROBOT LAWNMOWER

iRobot Corporation, Bedf...

1. An autonomous robot lawnmower comprising:a drive supporting the robot lawnmower above a lawn and configured to maneuver the robot lawnmower about the lawn;
a motorized lawn cutting assembly comprising one or more blades;
a first blade guard movably mounted to a first lateral side of the robot lawnmower, positioned at least partially below a horizontal plane in which the one or more blades of the cutting assembly are located, and extending from the first lateral side of the robot lawnmower toward the lawn, the first blade guard being movable toward the one or more blades of the cutting assembly, wherein the first blade guard has a substantially planar front facing surface forming a non-perpendicular angle with a substantially planar outward facing surface of the first blade guard such that a rearward directed force on the front facing surface moves the first blade guard towards the one or more blades of the cutting assembly; and
a second blade guard movably mounted to a second lateral side of the robot lawnmower and extending from the second lateral side toward the lawn, the second blade guard being movable toward the one or more blades of the cutting assembly, wherein the second blade guard has a front facing surface forming a non-perpendicular angle with an outward facing surface of the second blade guard such that a rearward directed force on the front facing surface of the second blade guard moves the second blade guard towards the one or more blades of the cutting assembly.

US Pat. No. 10,244,677

HAND TOOLS HAVING A PROTECTIVE HAND GUARD

1. A tool comprising:a first rake body having a proximal end and an opposite distal end, the first rake body comprising:
a handle portion extending from the proximal end toward the distal end of the first rake body, wherein the handle portion has a planar shape defining a top surface, an opposite bottom surface, a first side, and an opposite second side of the handle portion, and wherein the handle portion comprises: a finger opening extending from the top surface to the bottom surface of the handle portion and configured to receive a user's fingers therethrough;
a first plurality of tabs extending laterally outward along the first side of the handle portion; and
a second plurality of tabs extending laterally outward along the second side of the handle portion; and
a first rake portion extending from the distal end of the first rake body to the handle portion, wherein the first rake portion is integrally formed with the handle portion, wherein a majority of the first rake portion has a planar shape and is coplanar with the handle portion, and wherein the first rake portion comprises:
a plurality of tines; and
a plurality of cross-members extending between adjacent tines and oriented transverse to a longitudinal extent of the tines; and
a hand guard attached to the first rake body and positioned over a top surface of the handle portion, wherein the hand guard comprises an open proximal end, an opposite, closed distal end, and a plurality of walls defining an interior space configured to receive the user's hand therein, and wherein the plurality of walls of the hand guard comprises:
a front wall positioned along the distal end of the hand guard;
a top wall extending from the proximal end of the hand guard to the front wall;
a first sidewall extending from the proximal end of the hand guard to the front wall, wherein the first sidewall extends below the bottom surface of the handle portion, and wherein the first sidewall comprises a first plurality of mounting holes engaging the first plurality of tabs; and
a second sidewall extending from the proximal end of the hand guard to the front wall, wherein the second sidewall extends below the bottom surface of the handle portion, and wherein the second sidewall comprises a second plurality of mounting holes engaging the second plurality of tabs.

US Pat. No. 10,244,676

SELF-PROPELLED AGRICULTURAL PRODUCT APPLICATION IMPLEMENT

CNH Industrial America LL...

1. A self-propelled agricultural product application implement for delivering liquid or dry product to an agricultural field, the implement comprising:a chassis defining front and back ends and supporting a cab, an engine, and an applicator arrangement for delivering a liquid or dry product to an agricultural field;
a product container for storing the liquid or dry product and arranged at least partially between the front and back ends of the chassis, the product container including multiple container sections storing respective portions of the liquid or dry product and separated from each other by at least one divider wall extending transversely with respect to the implement such that the multiple container sections are longitudinally aligned with each other along a longitudinal axis of the implement;
an outlet system including multiple variable outlet arrangements respectively arranged between the multiple container sections and the applicator arrangement, the outlet system configured to selectively permit product to flow from one of the multiple container sections, past a respective one of the multiple variable outlet arrangements, and out of the applicator arrangement;
a control system operatively connected to the product container and to the outlet system, the control system configured to:
monitor weights of each of the multiple container sections;
determine an actual front-to-back weight distribution of the implement;
determine an emptying strategy for emptying the multiple containers at different times such that the actual front-to-back weight distribution of the implement approximates a target front-to-back weight distribution of the implement that provides a desired traction characteristic for the implement; and
command the outlet system to selectively permit product to flow from a selected one of the multiple container sections in accordance with the emptying strategy.

US Pat. No. 10,244,675

FIELD ROBOT

Veritas FC LLC, Spokane,...

1. An autonomous mobile field robot configured to be used in a field having sub-regions, the field robot comprising:one or more environment sensors;
a global positioning system (GPS) receiver;
one or more collapsible set of wings having a first position to let light through to at least one of the sub-regions and a second position to block the light and to provide shade to the at least one sub-region;
one or more chemical storage units for adjusting one or more parameters of a soil of the sub-regions;
a processor;
a network interface coupled to the processor configured to enable communications via a radio access network;
a storage device for content and programming;
a program stored in the storage device, wherein execution of the program by the processor configures the field robot to perform acts comprising:
performing soil mechanics with the one or more environment sensors at each sub-region and storing the soil mechanics in the storage device;
determining a soil temperature of each sub-region and storing the soil temperature in the storage device;
sending the soil mechanics and the soil temperature for each sub-region to a monitoring server via the radio access network for storage and analysis;
adjusting one or more parameters of the soil of a sub-region based on the soil mechanics of the corresponding sub-region with the chemicals from the one or more chemical storage units;
determining whether to provide shade to the sub-region based on at least one of the soil mechanics and the soil temperature corresponding to the sub-region; and
setting the one or more collapsible set of wings to the second position to provide the shade to the sub-region in response to determining to provide the shade.

US Pat. No. 10,244,674

MULTIPLE AGRICULTURAL PRODUCT APPLICATION METHOD AND SYSTEMS UTILIZING A DRUM METERING SYSTEM

Kinze Manufacturing, Inc....

1. A row unit for use with an agricultural planting implement and capable of planting a variety of seed types in a single field, the row unit comprising:a seed meter comprising:
a. a rotatable seed drum including a plurality of seed paths comprising a plurality of seed cells spaced about the seed drum, each of said seed paths corresponding to one of the variety of seed types to be planted and each of the seed paths adjacent to one another on a single drum, said rotatable seed drum further comprising a plurality of seed pools corresponding to the number of seed paths; and
b. a discharge mechanism operatively connected to the plurality of seed paths, wherein operation of the discharge mechanism with a seed path will discharge a seed variety associated with said path from the seed cells; and
a seed to ground system for directing the selected seed variety associated with the selected seed path to the ground for planting.
US Pat. No. 10,247,731

SYSTEM FOR IMMUNOTHERAPY TARGETING TUMOR PROPAGATION AND PROGRESSION

Verik Bio, Inc., Benson,...

1. An isolated tumor C-RC cell population prepared by(a) obtaining a tumor sample from an individual;
(b) cultivating the tumor sample under conditions that induce a stress response in non-C-RC differentiating and differentiated cells leading to apoptosis and necrosis but permit C-RC cells to propagate through the activation of a regenerative response;
(c) isolating the dominant actively expanding, most rapidly dividing population of cells from step (b); and
(d) culturing the cells to obtain a population of 51% to 100% C-RC,
in a serum-free, defined cell culture medium containing agents selected from the group consisting of agents inducing the apoptosis and/or necrosis of the cells, cAMP elevating agents, agents inhibiting cell-cell adhesion, nitric oxide, tumor necrosis factor-alpha (TNF-?), interleukin 1-beta (IL1-?), interferon-gamma (IFN-?), agents disrupting cell adhesion, agents interfering with survival of more differentiated cells, and calcium in a concentration of less than about 1 mM calcium,
wherein 80-100% of the C-RC population consists of actively expanding and dividing VSEC, SDEC and SCEC cells and abnormal transit amplifying cells.
US Pat. No. 10,246,710

DOUBLE STRAND RNA AS MOLECULAR BIOPESTICIDES FOR RNA INTERFERENCE THROUGH FEEDING IN THE HEMIPTERAN INVASIVE INSECT PEST, BROWN MARMORATED STINK BUG

The United States of Amer...

1. A double-stranded ribonucleic acid (dsRNA) comprising a sense region with at least 95% sequence identity to any one of SEQ ID NOs: 56, 66, 67, or 68 and an antisense region comprising a second sequence complementary to the sense region, wherein said dsRNA is capable of inducing ribonucleic acid interference (RNAi) in an insect.
US Pat. No. 10,247,734

LECTINS AND APPLICATIONS FOR THE DETECTION OF PATHOLOGICAL STATE MARKERS

CENTRE NATIONAL DE LA REC...

1. A monomeric, single polypeptide chain lectin having a ?-propeller architecture, said lectin comprising 4 to 7 peptide modules,wherein each module comprises about 30 to 60 amino acids;
wherein each module comprises a glycan binding site;
wherein at least one glycan binding site comprises at least one mutation, said mutation altering glycan binding;
wherein each module is linked to another module with a peptide linker; and
wherein at least one peptide linker is an exogenous peptide linker.
US Pat. No. 10,247,479

VORTEX WELL INERTING

1. A method of providing an inerting atmosphere to the surface of molten aluminum in a vortex charge well of a reverberatory melting furnace, the method comprising: introducing a flow of an inerting gas into an inerting region immediately above the surface of the vortex charge well.
US Pat. No. 10,246,456

IRAK4 INHIBITING AGENTS

BIOGEN MA INC., Cambridg...

1. A compound selected from:6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridine-2-amine;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyrimidin-4-amine;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-yl)methanamine;
4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-amine;
5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyrimidin-4-yl)methanamine;
4-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
3-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-5-nitropyridin-2-ol;
3-amino-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-ol;
N-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
N-methyl-1-(3-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)phenyl)methanamine;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinonitrile;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinic acid;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-methylpicolinamide;
2-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyrimidine-4-carbonitrile;
5-(1-(3-chloro-6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(5-fluoro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(5-methyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinonitrile;
6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
methyl 6-(5-aminopyridin-3-yl)-1-(6-cyanopyridin-2-yl)-1H-indazole-4-carboxylate;
methyl 6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylate;
6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylic acid;
6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
5-(4-(aminomethyl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
(6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylate;
(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
6-(6-(1-aminoethyl)pyridin-2-yl)-N,N-dimethyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(5-aminopyridin-3-yl)-N,N-dimethyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(5-aminopyridin-3-yl)-N-methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-amine;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-5,6,7,8-tetrahydroquinolin-8-amine;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N,N-dimethylpicolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-hydroxyethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(3-hydroxypropyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-hydroxypropyl)picolinamide;
(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-(dimethylamino)ethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-cyanoethyl)picolinamide;
N-(2-aminoethyl)-6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(cyanomethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-(methylsulfonyl)ethyl)picolinamide;
2-(aminomethyl)-6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
2-(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)acetonitrile;
2-(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)acetic acid;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-amino-N-(cyanomethyl)-4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinamide;
1-(5-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-yl)ethanamine;
1-(4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazine-2-carbonitrile;
(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazin-2-yl)methanamine;
4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrimidine-2-carbonitrile;
(4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrimidin-2-yl)methanamine;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazin-2-amine;
6-(6-(pyrrolidin-2-yl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole;
6-(6-(1-methylpyrrolidin-2-yl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
6-(6-(1-aminoethyl)pyridin-2-yl)-N,N-dimethyl-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
N-(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)acetamide;
1-(6-(4-(aminomethyl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-((6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)methyl)acetamide;
1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-cyclopropyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(prop-1-en-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-ethyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-isopropyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(trifluoromethyl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxylate;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxylic acid;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)methanol;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxamide;
N-methyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-methyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-methyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-cyclopropylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-ethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-isopropylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(4-methyl-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-4-(trifluoromethyl)pyridin-2-yl)ethanamine;
6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
cyclopropyl(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
2-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-2-amine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
cyclopropyl(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
1-(6-(1-(4-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(5-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(2-methylthiazol-4-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(1-methyl-1H-imidazol-4-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-4-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-5-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-5-yl)methanamine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)isonicotinamide;
N,N-dimethyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
1-(6-methylpyridin-2-yl)-6-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole;
6-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(6-cyclopentylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
1-(6-(4-fluoro-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
N-(5-(4-cyano-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroacetamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-5H-cyclopenta[b]pyridin-7(6H)-one;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinonitrile;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-6,7-dihydroquinolin-8(5H)-one;
6-amino-4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinic acid;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carbonitrile;
1-(6-(4-(aminomethyl)-2-(6-methylpyridin-2-yl)-2H-indazol-6-yl)pyridin-2-yl)ethanamine;
N,N-dimethyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(Z)-1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N,N-dimethyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
tert-butyl (6-(6-acetylpyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)(methyl)carbamate;
(Z)-tert-butyl (6-(6-(1-(hydroxyimino)ethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)(methyl)carbamate;
(Z)-1-(6-(4-(methylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
1-(6-(1-(6-ethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(E)-1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
2-(aminomethyl)-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(E)-1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
(E)-1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
6-(6-(6-acetylpyridin-2-yl)-1H-indazol-1-yl)picolinonitrile;
(E)-methyl 6-(6-(6-(1-(hydroxyimino)ethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinate;
1-(6-(1-(4-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
1-(6-(4-fluoro-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(3-fluoro-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 3-amino-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)picolinate;
2,2,2-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
1-(6-(4-ethoxy-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-methoxy-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-ol;
6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)picolinamide;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-ol;
1-(6-(4-(cyclopropylmethoxy)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)methanamine;
N-((6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methyl)acetamide;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-3-(trifluoromethyl)pyridin-2-yl)ethanamine;
2-(1-aminoethyl)-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)methanol;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
2,2,2-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanoic acid;
methyl 3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanoate;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclopropanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(R)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
1-(3-chloro-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
2-(1-aminoethyl)-6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
methyl 2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetate;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetic acid;
6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)propan-2-ol;
1-(6-(1-(6-(methoxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(3-methyl-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-methylthiophen-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-propylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)oxazol-2-yl)methanamine;
1-(6-(1-(6-(tert-butyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2-methylpropanenitrile;
1-(6-(1-(6-(2-(methylsulfonyl)propan-2-yl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)cyclopropanecarbonitrile;
(6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)propan-2-amine;
(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(4-(1H-imidazol-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-methylpyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-2-amine;
1-(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)ethanol;
(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)methanamine;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2-methylpropanamide;
1-(6-(1-(6-methylpyridin-2-yl)-4-(thiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclobutanecarbonitrile;
1-(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)ethanamine;
1-(6-methylpyridin-2-yl)-6-(pyridin-2-yl)-1H-indazole;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-amine;
(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
1-(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclobutanecarboxamide;
1-(6-methylpyridin-2-yl)-6-(6-(3,3,3-trifluoropropyl)pyridin-2-yl)-1H-indazole;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
1-(6-(1-(4,6-dimethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-N-methyl-1H-indazole-4-carboxamide;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-4-(1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)methanol;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-fluoro-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
6-(1-methyl-1H-imidazol-4-yl)-1-(6-methylpyridin-2-yl)-1H-indazole;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(piperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidin-3-ol;
(1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(methylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(ethylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-4-ol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-3-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoroazetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-3-(chloromethyl)azetidin-3-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoropyrrolidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(2-methylmorpholino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(2,6-dimethylmorpholino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
3-((6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)amino)-2-(chloromethyl)propanoic acid;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)thiomorpholine 1,1-dioxide;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-thiomorpholino-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-morpholino-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-dimethylazetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidine-3-carboxylic acid;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(pyrrolidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(4-methylpiperazin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((3-chloro-2,2-dimethylpropyl)amino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(azetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(4,4-difluoropiperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoropiperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)azetidine-3-carboxylic acid;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidine-3-carboxylic acid;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidine-4-carboxylic acid;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)morpholin-3-one;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-methyl-1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-imidazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-1,2,4-triazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-(trifluoromethyl)-1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-ethylpyridin-2-yl)-4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(oxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-imidazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methylthiazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-2-(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)thiazole-4-carbonitrile;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(isothiazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-phenyl-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-(trifluoromethyl)oxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-methylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4,5-dimethylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-(trifluoromethyl)thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-(trifluoromethyl)thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-(trifluoromethyl)thiazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-(trifluoromethyl)-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-fluoropyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(difluoromethyl)-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(difluoromethyl)-1H-pyrazol-5-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(4-(1,5-dimethyl-1H-pyrazol-3-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyridazin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidin-2-yl)methanol;
(S)-(3-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)phenyl)methanol;
(S)-(2-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidin-4-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(2-(1-aminobutyl)pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(2-(1-aminobutyl)pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-methoxy-1H-indazol-6-yl)pyridin-2-yl)butan-1-01;
(S)-(6-(6-(4-(1-aminoethyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminoethyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-(6-((S)-1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
deutero (S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(8-amino-8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(8-amino-8-propyl-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclobutyl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methylpiperidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(tetrahydro-2H-pyran-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-2-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)ethanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyrazin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4S)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4R)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4S)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4R)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(6-(6-(6-((1R)-1-amino-2-fluoropropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1S)-1-amino-2-fluoropropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobut-3-en-1-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3-methylbut-3-en-1-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(amino(phenyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(phenyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopent-3-yn-1-yl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2S)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2R)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(amino(oxetan-3-yl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(amino(oxetan-3-yl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-amino-2-(3-methyloxetan-3-yl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-one;
(S)-6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)picolinaldehyde;
(R)-1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroethanol;
(S)-1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroethanol;
(6-(6-(6-((1R,2R)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2S)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-3-((6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-3-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-3-((6-(6-(1-aminopropyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-2-methylbut-3-yn-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(3-aminooxetan-3-yl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(3-aminotetrahydrofuran-3-yl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(6-(6-(6-(1-aminocyclopentyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-(methylsulfonyl)ethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)-2-methylpropan-2-ol;
6-{6-[6-((S)-1-Amino-ethyl)-pyridin-2-yl]-indazol-1-yl}-pyridine-2-carboxylic;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(6-{6-[6-((S)-1-Amino-ethyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(tetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((2R,5R)-5-methyltetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((2S,5R)-5-methyltetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-isopropoxy-indazol-1-yl}-pyridin-2-yl)-methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(methylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(fluoromethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-chloro-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(difluoromethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
(S)-(6-(6-(6-(1-aminopentyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,6-dihydro-2H-pyran-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(methoxymethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((difluoromethoxy)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(morpholinomethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-1-(6-(4-methoxy-1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(4-ethoxy-1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(piperidin-3-ylmethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-amino-1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2,2,2-trifluoroethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-1-yl)ethanone;
1-amino-1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((dimethylamino)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(fluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(1-amino-2-(methylthio)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3-methylbutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-cyclopropylethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(trifluoromethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4,5-dihydrooxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(difluoromethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-(methylamino)butyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminoethyl)pyridin-2-yl)-4-(4-methyl-4,5-dihydrooxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
(S)-1-(6-(1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(1-amino-2-(methylsulfonyl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-6-(6-(1-aminopropyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(6-(6-(6-(1-amino-2-cyclopropylethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-4-(oxazol-5-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(S)-6-(6-(1-aminoethyl)pyridin-2-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(oxazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-amino-2-methoxyethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)-N,N-dimethylacetamide;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)-3-fluoropyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(trifluoromethyl)pyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
6-(6-((S)-1-aminoethyl)pyridin-2-yl)-N-(2-aminopropyl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
3,3,3-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
1-(6-(4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetamide;
4-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidine-2-carbonitrile;
(6-(6-(3-(1-aminoethyl)phenyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminoethyl)-3-fluoropyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)-5-fluoropyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-(dimethylamino)butyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)-N-methylacetamide;
(6-(6-(6-(1-amino-2-(methylsulfinyl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(1-methoxyethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(4-chloro-1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(pyrrolidin-2-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((S)-pyrrolidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyloxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((trifluoromethoxy)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminopentyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-3-amino-3-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanenitrile;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(5-methyloxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-3-chloropropan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-methylpyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-3-amino-3-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanenitrile;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butanenitrile;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(tetrahydrofuran-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol; and
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((3,3-difluorocyclobutyl)methoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,247,736

IDENTIFICATION AND QUANTIFICATION OF BIOMARKERS FOR EVALUATING THE RISK OF PRETERM BIRTH

BRIGHAM YOUNG UNIVERSITY,...

1. A method of identifying subjects at risk for preterm birth, the method comprising the steps of:(a) protein depleting a serum or blood sample from a pregnant subject, wherein the protein depleting includes treating the serum or blood sample with a volume of acetonitrile;
(b) fractionating the protein depleted sample to isolate at least one biomarker selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3;
(c) detecting a concentration of the at least one isolated biomarker by mass spectrometry; and
(d) identifying the pregnant subject as being at risk for preterm birth when the concentration of the at least one isolated biomarker is less than a control concentration of the at least one biomarker.
US Pat. No. 10,246,715

CPG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION INCLUDING THE SAME, AND METHOD OF INDUCING IMMUNE RESPONSE BY THE SAME

National Health Research ...

1. A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host, comprising:one or more copies of the sequence of GTCGTT;
one or more copies of the sequence of GTT; and
one or more copies of the sequence of TTTT;
wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT, and
the CpG-ODN comprises the sequence of SEQ ID NO: 1.
US Pat. No. 10,246,719

MODULATING LACCASE ENZYME TO REGULATE CELL WALL BIOSYNTHESIS AND RECALCITRANCE IN PLANTS

UT-BATTELLE, LLC, Oak Ri...

1. A genetically modified plant characterized by a reduced expression of the LAC2 gene as compared to a control plant, wherein the genetic modification is specifically targeted at the LAC2 gene or the LAC2 mRNA to reduce the LAC2 gene expression.
US Pat. No. 10,247,743

ANALYTE TESTING AUTOMATION SYSTEM, BIOLOGICAL SAMPLE CHECK MODULE, AND BIOLOGICAL SAMPLE CHECK METHOD

Hitachi High-Technologies...

1. An analyte testing automation system comprising:a camera configured to capture an image of a container, in which a biological sample is stored, from a side thereof;
a grip member configured to grasp and lift the container;
a database which stores a plurality of different container types that specify a plurality of different lifting operation parameters and a plurality of different threshold parameters;
a controller coupled to the camera and the grip member, and programmed to:
control the camera to capture a first image of the container,
determine a container type of the container from among the different container types stored in the database according to a length, a diameter and a cap color of the container in the first image,
determine a lifting operation parameter and a threshold parameter of the container from the different lifting operation parameters and the different threshold parameters in the database specified by the determined container type,
control the grip member to lift the container to a predetermined height specified by the lifting operation parameter,
capture a second image of the container in a state where the container is lifted to the predetermined height by the grip member,
compare the second image to one or more predetermined color values specified by the threshold parameter, and
determine a state of an analyte in the biological sample in the container from the comparison.
US Pat. No. 10,246,721

SUGAR TRANSPORTERS

Carnegie Institution of W...

1. A method of inhibiting the expression or activity of a SWEET transporter in a plant cell, the method comprising transforming the plant cell with an expression vector, the expression vector comprising a nucleic acid sequence coding for one or more polynucleotides that form a double-stranded RNA (dsRNA) to inhibit a nucleic acid sequence in the plant cell coding for at least one of a SWEET4 transporter, a SWEET15 transporter, and a SWEET17 transporter, wherein said nucleic acid sequence is expressed in said plant cell, which, when said nucleic acid sequence is expressed said dsRNA is formed, wherein said dsRNA reduces sugar efflux out of the plant cell, wherein the plant cell is from or in soybean, rice, tomato, alfalfa, potato, pea, grasses, herbs, trees, algae, mosses, fungi, vines, ferns, bushes, barley, wheat, hops, maize, lettuce, orange, peach, citrus, lemon, lime, coconut, palm, pine, oak, cedar, mango, pineapple, rhubarb, strawberry, blackberry, blackcurrant, blueberry, raspberry, kiwi, grape, rutabaga, parsnip, sweet potato, turnip, pepper, cilantro, onion, leek, fennel, clove, avocado, cucumber, Miscanthus, poplar, sorghum, or Brachypodium, wherein the reduction in efflux of sugar out of the plant cell increases pathogen resistance of the plant cell to Botrytis cinerea.
US Pat. No. 10,247,745

GLYCAN SAMPLE PREPARATION

Beckman Coulter, Inc., B...

1. A method of analyzing one or more glycoconjugates, comprising:reacting a sample containing one or more glycoconjugates with a deglycosylation reagent to release glycans from the glycoconjugates;
associating the glycans with a plurality of magnetic particles;
applying a magnetic field to draw down the plurality of magnetic particles having the glycans associated therewith;
removing a supernatant from the drawn-down magnetic particles so as to remove the deglycosylation reagent and deglycosylated sample;
reacting the glycans with a labeling reagent so as to form labeled glycans;
analyzing the labeled glycans;
wherein the magnetic particles are carboxyl-coated magnetic beads; and
wherein the glycans are associated with the plurality of magnetic particles by adding acetonitrile.
US Pat. No. 10,244,934

ATHERECTOMY CATHETER DRIVE ASSEMBLIES

Avinger, Inc., Redwood C...

11. A drive assembly for driving an imaging catheter having a rotatable fiber, the drive assembly comprising:a fiber optic rotating junction having a stationary portion with a stationary fiber therein and a rotatable portion with a rotatable fiber therein;
a first optical connector configured to connect the stationary fiber with a light source;
a motor configured to simultaneously rotate the rotatable portion of the fiber optic rotating junction and a rotatable shaft of the catheter, the motor having a shaft that is coaxial with a fiber of the fiber optic rotating junction; and
a second optical connector configured to connect the rotatable portion of the fiber optic rotating junction with the rotatable fiber of the imaging catheter so as to allow torque to simultaneously be transmitted from the motor to the rotatable shaft and the rotatable fiber of the catheter and so as to allow light to be transmitted from the light source to the rotatable fiber of the catheter.
US Pat. No. 10,246,727

FERMENTATION ROUTE FOR THE PRODUCTION OF LEVULINIC ACID, LEVULINATE ESTERS AND VALEROLACTONE AND DERIVATIVES THEREOF

ARZEDA CORP., Seattle, W...

1. A method for producing 2-oxo-4-valerolactone, the method comprising: converting pyruvate to 4-hydroxy-2-oxo-pentanoic acid by aldol addition, and converting 4-hydroxy-2-oxo-pentanoic acid to 2-oxo-4-valerolactone through lactonization.
US Pat. No. 10,244,691

ROOT-KNOT NEMATODE RESISTANCE MARKER FOR TOMATO PLANT, ROOT-KNOT NEMATODE RESISTANT TOMATO PLANT, PRODUCTION METHOD FOR ROOT-KNOT NEMATODE RESISTANT TOMATO PLANT, AND SCREENING METHOD FOR ROOT-KNOT NEMATODE RESISTANT TOMATO PLANT

1. A method of producing a root-knot nematode resistant tomato plant, the method comprising:detecting, in one or more tomato plants to be examined,
marker TY38 corresponding to the 21st nucleotide of SEQ ID NO: 22to identify a root-knot nematode resistance locus on chromosome 4 and select a root-knot nematode resistant tomato plant comprising the marker, andcrossing the root-knot nematode resistant tomato plant comprising the root-knot nematode resistance locus on chromosome 4 with a cultivated tomato plant to produce a progeny plant, wherein the progeny plant has the root-knot nematode resistance locus on chromosome 4.
US Pat. No. 10,246,484

METHOD FOR PURIFYING RECOMBINANT PROTEIN

SUNSHINE GUOJIAN PHARMACE...

1. A method for purifying a recombinant protein from a mixture comprising the recombinant protein and its related proteins, which comprises the following steps performed sequentially:A. binding the recombinant protein to an ion exchange medium using a first equilibration buffer, wherein the first equilibration buffer is at a first conductivity and pH;
the ion exchange medium is a cation exchange medium;
B. equilibrating the protein-bound ion exchange medium continually using a second equilibration buffer, wherein the second equilibration buffer is at a second conductivity and pH;
the conductivity of the second equilibration buffer is less than that of the first equilibration buffer, but the pH of both are the same;
C. washing the ion exchange medium using a wash buffer which has different pH, so as to elute a first class of the related proteins from the ion exchange medium, wherein the wash buffer is at a third conductivity and a gradually increased pH;
the conductivity of the wash buffer is less than that of the first equilibration buffer, but the pH of the wash buffer is greater than that of the first and/or second equilibration buffer;
D. washing the ion exchange medium using a first elution buffer, so as to elute the target recombinant protein from the ion exchange medium, wherein the first elution buffer is at a fourth conductivity and pH;
the pH of the first elution buffer is greater than that of the wash buffer, but the conductivity of both are essentially the same; and
E. then washing the ion exchange medium using a second elution buffer, so as to elute a second class of related proteins from the ion exchange medium, wherein the second elution buffer is at a fifth conductivity and pH;
the pH and/or conductivity of the second elution buffer are/is greater than that of the first elution buffer.
US Pat. No. 10,248,020

ACID GENERATORS AND PHOTORESISTS COMPRISING SAME

Rohm and Haas Electronic ...

14. A photoresist composition, comprising:(i) a polymer;
(ii) a first non-polymeric onium salt acid generator that produces a first acid upon exposure of the photoresist composition to activating radiation; and
(iii) a second onium salt acid generator that 1) comprises a covalently bound acid-labile moiety and 2) produces a second acid upon exposure of the photoresist composition to activating radiation;
wherein the first acid and second acid have pKa values that differ by at least 1;
wherein at least one of the first onium salt acid generator and the second onium salt acid generator comprises a thioxanthone moiety; and
wherein the first onium salt acid generator and the second onium salt acid generator are each not bound to a polymer.
US Pat. No. 10,244,693

HYBRID TOMATO VARIETY 72-759 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum tomato plant designated variety 72-759 RZ, representative seed of which having been deposited under NCIMB Accession No. 42682.
US Pat. No. 10,246,485

METHOD TO CONCENTRATE VON WILLEBRAND FACTOR OR COMPLEXES THEREOF

CSL LIMITED, Parkville (...

1. A method for concentrating von Willebrand Factor (VWF) from an aqueous solution comprising the steps of(a) precipitating the VWF by adding calcium ions and phosphate ions to the aqueous solution,
(b) separating the precipitate formed in step (a), and
(c) resolubilizing the precipitate isolated in step (b) by contacting the precipitate with an aqueous solution comprising a calcium complexing agent, wherein
the VWF comprises a full-length VWF polypeptide.
US Pat. No. 10,244,695

TOMATO HYBRID SV6133TM AND PARENTS THEREOF

SEMINIS VEGETABLE SEEDS, ...

1. A tomato seed of tomato hybrid SV6133TM, a sample of seed of said hybrid SV6133TM having been deposited under ATCC Accession Number PTA-122352.
US Pat. No. 10,246,744

METHOD AND SYSTEM FOR SEQUENCING NUCLEIC ACIDS

OMNIOME, INC., San Diego...

16. A method of sequencing a primed template nucleic acid, comprising:(a) contacting a primed template nucleic acid with a polymerase and a first combination of two and only two or three and only three types of test nucleotides under conditions that form a stabilized ternary complex between the polymerase, primed template nucleic acid and a test nucleotide that is complementary to the next base of the primed template nucleic acid;
(b) detecting the ternary complex while precluding incorporation of test nucleotides into the primer;
(c) repeating steps (a) and (b) using the primed template nucleic acid, a polymerase and a second combination of two or three types of test nucleotides, wherein the second combination is different from the first combination;
(d) incorporating into the primer, after step (c), a nucleotide that is complementary to the next base; and
(e) repeating steps (a) through (d) to identify a sequence of the primed template nucleic acid.
US Pat. No. 10,248,792

DETECTION AND HEALING OF VULNERABILITIES IN COMPUTER CODE

BlueRISC, Inc., Amherst,...

1. A method performed by one or more processing devices, comprising:during compilation of computer code by the one or more processing devices:
performing a static analysis of the computer code to identify a memory instruction in the computer code that constitutes a potential vulnerability in the computer code, the memory instruction comprising a memory store instruction that is repeatable and that uses contiguous memory during a repetition; and
inserting a healing template into the computer code at a location that is based on the potential vulnerability, the healing template being generic to a class of vulnerabilities; and
during execution of the computer code by the one or more processing devices:
updating the healing template based on an attack that occurred at the potential vulnerability, the healing template for inhibiting one or more subsequent attacks that occur at the potential vulnerability; and
using the healing template to inhibit the one or more subsequent attacks.
US Pat. No. 10,246,746

PRESERVING GENOMIC CONNECTIVITY INFORMATION IN FRAGMENTED GENOMIC DNA SAMPLES

Illumina, Inc., San Dieg...

1. A method of sequencing a target nucleic acid polymer, comprising:(a) modifying a target nucleic acid polymer to produce a modified nucleic acid polymer, wherein the modified nucleic acid polymer comprises a plurality of sequence regions from the target nucleic acid polymer;
(b) releasing fragments of the modified nucleic acid polymer onto a solid support surface, each fragment comprising one of the sequence regions;
(c) capturing the fragments randomly at locations in an area of the solid support surface;
(d) determining nucleotide sequences of the sequence regions by detecting the fragments at the locations;
(e) determining relative physical distances between the fragments at the locations; and
(f) producing a representation of the nucleotide sequence for the target nucleic acid polymer based on the nucleotide sequences from the fragments and the determined relative physical distances between the locations on the solid support surface, wherein the relative physical distances are indicative of distances between the sequence regions along a given strand of the target nucleic acid polymer.
US Pat. No. 10,244,700

SOYBEAN VARIETY 5PBDN11

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PBDN11, representative seed of the variety having been deposited under ATCC Accession Number PTA-125151.
US Pat. No. 10,244,703

INBRED CORN LINE 3EESL0003

Agrigenetics, Inc., Indi...

1. Seed of corn inbred line designated 3EESL0003, or a part thereof, representative seed of the line having been deposited under ATCC Accession No. PTA-123410.
US Pat. No. 10,244,704

SOYBEAN VARIETY 01068084

MONSANTO TECHNOLOGIES LLC...

1. A plant of soybean variety 01068084, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124739.
US Pat. No. 10,244,705

SOYBEAN VARIETY 01064265

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 01064265, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124747.
US Pat. No. 10,246,497

SELECTIVE PYY COMPOUNDS AND USES THEREOF

1. A PYY compound comprising tryptophan at the position corresponding to position 30 of hPYY(1-36) (SEQ ID NO:1), a maximum of 8 amino acid modifications as compared to hPYY(3-36), wherein the PYY compound comprises N(alpha)-methyl-L-arginine at a position corresponding to position 35 of hPYY(1-36) (SEQ ID NO:1), and wherein the positions corresponding to positions 1-2 or 1-3 of hPYY(1-36) (SEQ ID NO:1) are absent, or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,244,706

SOYBEAN VARIETY 01064571

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 01064571, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124755.
US Pat. No. 10,246,754

MOLECULAR MARKERS LINKED TO DISEASE RESISTANCE IN SOYBEAN

Syngenta Participations A...

1. A method of producing a soybean plant having an Asian soybean rust (ASR) resistance, the method comprising the steps of:a) isolating a nucleic acid from a soybean plant cell;
b) detecting in the nucleic acid of a) the presence of a haplotype associated with an ASR resistance allele, wherein said haplotype comprises a C at nucleotide 1 of SEQ ID NO: 1, a G at nucleotide 14 of SEQ ID NO: 1, a T at nucleotide 51 of SEQ ID NO: 1, a G at nucleotide 59 of SEQ ID NO: 1, a C at nucleotide 143 of SEQ ID NO: 1, a G at nucleotide 148 of SEQ ID NO: 1, and an A at nucleotide 157 of SEQ ID NO: 1;
c) identifying a first soybean plant on the basis of the presence of the haplotype detected in b);
d) crossing the first soybean plant with a second soybean plant not comprising said haplotype; and
e) producing a progeny plant from the cross of d), wherein said progeny plant comprises the haplotype detected in b), thereby producing a soybean plant having ASR resistance.
US Pat. No. 10,244,707

WHEAT VARIETY W070474I1

PIONEER HI-BRED INTERNATI...

1. A plant, plant part, seed, or plant cell of wheat variety W070474I1, representative seed of said variety having been deposited under ATCC accession number PTA-123444.
US Pat. No. 10,246,755

CRYSTALLIZED OXALATE DECARBOXYLASE AND METHODS OF USE

Allena Pharmaceuticals, I...

1. A pharmaceutical composition comprising a capsule containing crystals of spray-dried oxalate decarboxylase comprising the amino acid sequence of SEQ ID NO:1 where the thiol moiety at Cys383 is protected by a reaction with a thiol protecting group, wherein the crystals have a Hausner ratio of about 1.00 to about 1.59.
US Pat. No. 10,244,709

SOYBEAN CULTIVAR S170008

M.S. Technologies, LLC, ...

1. A plant of soybean cultivar S170008, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-124445.
US Pat. No. 10,246,501

FUSION POLYPEPTIDES AND METHODS OF USE

Prosit Sole Biotechnology...

1. A fusion polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 3-19.
US Pat. No. 10,246,757

BEARING PART

1. A bearing part comprising, as a chemical composition, by mass %,C: 0.95% to 1.10%,
Si: 0.10% to 0.70%,
Mn: 0.20% to 1.20%,
Cr: 0.90% to 1.60%,
Al: 0.010% to 0.100%,
N: 0.003% to 0.030%,
P: 0.025% or less,
S: 0.025% or less,
O: 0.0010% or less, and
optionally
Mo: 0.25% or less,
B: 0.0050% or less,
Cu: 1.0% or less,
Ni: 3.0% or less, and
Ca: 0.0015% or less, and
a remainder including Fe and impurities,
wherein a metallographic structure includes a retained austenite, a spherical cementite and a martensite,
wherein an amount of the retained austenite is 15% to 25%, by volume %,
wherein an average grain size of a prior-austenite is 8.0 ?m or less, and
wherein a number density of a void having a circle equivalent diameter of 0.02 ?m to 3.0 ?m is 2000 mm?2 or less in the metallographic structure.
US Pat. No. 10,248,037

DEVELOPER, DEVELOPER STORAGE BODY, DEVELOPING DEVICE AND IMAGE FORMING APPARATUS

Oki Data Corporation, To...

1. A developer comprising developer particles, each of the developer particles comprising:a binder resin;
a brilliant pigment whose principal component is aluminum;
a yellow pigment;
a magenta pigment;
a reddish-orange fluorescent dye; and
a yellow fluorescent dye,
wherein when an average particle diameter of the brilliant pigments included in the developer particles is expressed as D (?m), a number proportion of the developer particles having particle diameters in a range from 4 ?m to 1.2×D ?m in whole developer particles is less than or equal to 4%.
US Pat. No. 10,246,502

IL22 IMMUNOCONJUGATES

Philogen S.P.A., Siena (...

1. A conjugate comprising interleukin-22 (IL22) and an antibody molecule, wherein the antibody molecule comprises an antigen-binding site which binds the Extra Domain-A (ED-A) of fibronectin and comprises the complementarity determining regions (CDRs) of antibody F8 set forth in SEQ ID NOs 1-6, and wherein the IL22 comprises the sequence set forth in SEQ ID NO: 11.
US Pat. No. 10,246,758

METHOD FOR PRODUCING A COMPONENT FROM STEEL BY HOT FORMING

SALZGITTER FLACHSTAHL GMB...

1. A method for the production of a component from transformable steel, comprising the steps in the order of:cutting to size a blank as source material from a strip or metal sheet;
austenitizing and quenching the blank such as to produce a partly martensitic transformation microstructure and a residual austenite microstructure, by heating the blank to an austenitizing temperature within a continuous annealing process and subsequently quenching the blank;
applying a coating on the blank by a hot dip process after the annealing process;
reheating the blank to a forming temperature below the Ac1 transformation temperature, while maintaining the partly martensitic transformation microstructure and the residual austenite microstructure; and
forming the blank at the forming temperature below the Ac1 transformation temperature into the component while still maintaining the partly martensitic transformation microstructure and the residual austenite microstructure in the component.
US Pat. No. 10,244,711

SOYBEAN CULTIVAR S170024

M.S. TECHNOLOGIES, LLC, ...

1. A plant of soybean cultivar S170024, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-124464.
US Pat. No. 10,248,039

CARRIER, ELECTROPHOTOGRAPHIC DEVELOPER, AND METHOD OF MANUFACTURING CARRIER

POWDERTECH CO., LTD., Ch...

1. A carrier which is a core material composed of a magnetic component and a non-magnetic component coated with a resin, characterized in thatthe carrier has water content of 200 ppm or less and cyclic siloxane content of 100 ppb or less.
US Pat. No. 10,244,714

LETTUCE LINE SVLN7347

Seminis Vegetable Seeds, ...

1. A seed of lettuce line SVLN7347, a sample of seed of said line having been deposited under ATCC Accession Number PTA-123429.
US Pat. No. 10,246,506

METHODS FOR REDUCING LEVELS OF PROTEIN-CONTAMINANT COMPLEXES AND AGGREGATES IN PROTEIN PREPARATIONS BY TREATMENT WITH ELECTROPOSITIVE ORGANIC ADDITIVES

AGENCY FOR SCIENCE, TECHN...

1. A method of reducing the aggregate content of a sample, wherein the sample comprises a target antibody and aggregates comprising nucleic acid contaminants associated with the target antibody, the method comprising:(a) contacting the sample with an electropositive organic additive at a non-zero amount of 0.1% weight/volume or less, and an undissolved allantoin, thereby forming a mixture comprising allantoin and precipitated nucleic acid contaminants, wherein allantoin is supersaturated in the mixture and the electropositive organic additive comprises ethacridine or polyethyleneimine; and
(b) removing the undissolved allantoin and precipitated nucleic acid contaminants from the sample,
wherein the sample, after (b) comprises the target antibody and a reduced amount of the aggregates, wherein the sample is derived from a cell culture or cell culture supernatant, and the target antibody is a recombinant antibody.
US Pat. No. 10,246,508

ANTI EOTAXIN-2 ANTIBODIES THAT RECOGNIZE ADDITIONAL CCR3-BINDING CHEMOKINES

CHEMOMAB LTD., Tel Aviv ...

1. A nucleic acid molecule encoding a humanized antibody that binds to at least two CCR3-binding chemokines wherein said nucleic acid molecule comprises the sequence denoted by SEQ ID NO: 1 and SEQ ID NO: 2.
US Pat. No. 10,244,717

MAIZE INBRED PH42YV

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH42YV, representative seed of the variety having been deposited under ATCC accession number PTA-124767.
US Pat. No. 10,245,229

PULMONARY DELIVERY OF MRNA TO NON-LUNG TARGET CELLS

Translate Bio, Inc., Lex...

1. A method of delivery of messenger RNA (mRNA) to a non-lung cell or tissue comprising administering to the lung by nebulization a composition comprising mRNA encoding a protein and a lipid carrier vehicle comprising one or more PEG-modified lipids, wherein the administering to the lung results in the delivery of the mRNA to a non-lung cell or tissue, and wherein the protein encoded by the mRNA is detectable in the non-lung cell or tissue for at least 6 hours following the administration to the lung.
US Pat. No. 10,246,509

RESTRICTED IMMUNOGLOBULIN HEAVY CHAIN MICE

Regeneron Pharmaceuticals...

1. A rat or a mouse whose germline genome comprises:a restricted immunoglobulin heavy chain locus characterized by the presence of a single human unrearranged VH1-69 gene segment, one or more human unrearranged DH gene segments, and one or more human unrearranged JH gene segments operably linked to a non-human immunoglobulin heavy chain constant region nucleic acid sequence comprising at least a non-human IgM gene at an endogenous heavy chain locus of the rat or mouse,
wherein the restricted immunoglobulin heavy chain locus is capable of rearranging and forming a plurality of distinct rearrangements, wherein each rearrangement is derived from the single human VH1-69 gene segment, one of the human DH segments, and one of the human JH segments, and wherein each rearrangement encodes a different heavy chain variable domain, and
wherein the rat or mouse further comprises a population of mature IgMintIgDhi B cells in its spleen, each B cell comprising a distinct rearranged human heavy chain variable region gene sequence derived from the restricted immunoglobulin heavy chain locus.
US Pat. No. 10,246,765

MARTENSITIC CR-CONTAINING STEEL AND OIL COUNTRY TUBULAR GOODS

1. A martensitic Cr-containing steel, comprising:a chemical composition consisting of, by mass %,
Si: 0.05 to 1.00%,
Mn: 0.1 to 1.0%,
Cr: 8 to 12%,
V: 0.01 to 1.0%,
sol. Al: 0.005 to 0.10%,
N: not more than 0.100%,
Nb: 0 to 1%,
Ti: 0 to 1%,
Zr: 0 to 1%,
B: 0 to 0.01%,
Ca: 0 to 0.01%,
Mg: 0 to 0.01%, and
rare earth metal (REM): 0 to 0.50%, and further consisting of one or two selected from the group consisting of
Mo: 0 to 2% and
W: 0 to 4%, with the balance being Fe and impurities, wherein the impurities include
C: not more than 0.10%,
P: not more than 0.03%,
S: not more than 0.01%,
Ni: not more than 0.5%, and
O: not more than 0.01%, and wherein
an effective Cr amount defined by Formula (1) is not less than 8%, and
an Mo equivalent defined by Formula (2) is 0.03 to 2%;
a micro-structure wherein a grain size number (ASTM E112) of prior-austenite crystal grain is not less than 8.0, and which consists of, in volume fraction, 0 to 5% of ferrite and 0 to 5% of austenite, with the balance being tempered martensite; and
a yield strength of 379 to less than 551 MPa, wherein
a grain-boundary segregation ratio, which is defined, when either one of Mo and W is contained, as a ratio of a maximum content at grain boundaries to an average content within grains of the contained element, and when Mo and W are contained, as an average of ratios of a maximum content at grain boundaries to an average content within grains of each element, is not less than 1.5:
Effective Cr amount=Cr?16.6×C  (1)
Mo equivalent=Mo+0.5×W  (2)
where, symbols of elements in Formulae (1) and (2) are substituted by corresponding contents (by mass %) of the elements.
US Pat. No. 10,245,230

METHOD FOR INCORPORATING ACTIVE AGENTS INTO A HYDROPHILIC POLYMER FOAM

LABORATOIRES URGO, Cheno...

1. A process for manufacturing a hydrophilic polymer foam exhibiting a gradient of a water-soluble active agent, the process comprising:a) depositing an aqueous solution or dispersion comprising the water-soluble active agent on an impermeable nonporous support;
b) pouring a precursor mixture of the foam, in a form of an aqueous dispersion comprising either monomers or prepolymers, over the aqueous solution or dispersion that has been deposited on the support at the end of step a), wherein the aqueous solution or dispersion that has been deposited on the support at the end of step a) dissolves in the precursor mixture of the foam;
c) polymerizing the precursor mixture in which the water-soluble active agent is dissolved in step b) to produce the hydrophilic polymer foam incorporating the water-soluble active agent;
d) drying the hydrophilic polymer foam; and
e) separating the impermeable nonporous support from the foam after the foam has been dried in step d),
wherein 80% -90% of the total weight of the water-soluble active agent is found in the lower 33% of the total volume of the hydrophilic polymer foam, which is the volume of the foam closest to the impermeable nonporous support at the end of step d).
US Pat. No. 10,246,766

CONCURRENT FLOW OF ACTIVATING GAS IN LOW TEMPERATURE CARBURIZATION

SWAGELOK COMPANY, Solon,...

1. A process for surface hardening a workpiece made from an iron, nickel and/or chromium based alloy by gas carburization in which an unsaturated hydrocarbon is contacted with the workpiece inside a carburization reactor under a pressure of about 3.5 to 100 torr and at an elevated carburization temperature to cause carbon to diffuse into the workpiece surfaces thereby forming a hardened primary surface layer which is essentially free of carbide precipitates as well as a thermal oxide film, the process further comprising increasing the rate at which carburization occurs by feeding a carbon-free, halogen-containing activating compound to the carburization reactor simultaneously with feeding the unsaturated hydrocarbon to the carburization reactor, wherein the unsaturated hydrocarbon is acetylene, the concentration of the of the unsaturated hydrocarbon inside the carburization reactor is about 8 to 35 vol. % and the concentration of the carbon-free, halogen-containing activating compound inside the carburization reactor is about 0.5 to 3 vol. %.
US Pat. No. 10,246,511

FUSION POLYPEPTIDE CAPABLE OF BINDING SIMULTANEOUSLY TO VEGF-C AND VEGF-D

SAMSUNG ELECTRONICS CO., ...

1. A fusion polypeptide capable of binding simultaneously to VEGF-C and VEGF-D, comprising a VEGFR2 extracellular domain, a VEGFR3 extracellular domain, and the Fc region of an immunoglobulin, wherein the VEGFR2 extracellular domain comprises Ig-like domain 2, and the VEGFR3 extracellular domain comprises Ig-like domain 2.
US Pat. No. 10,244,721

SOYBEAN VARIETY 5PQNE01

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PQNE01, representative seed of the variety having been deposited under ATCC Accession Number PTA-125284.
US Pat. No. 10,246,515

METHODS OF TREATING HEDGEHOG-RELATED DISEASES WITH AN ANTI-LGR5 ANTIBODY

Genentech, Inc., South S...

1. A method of treating a hedgehog-related disease in an individual comprising administering to the individual an effective amount of an anti-Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) antibody, wherein the anti-LGR5 antibody comprises:a) hypervariable region (HVR)-H1 comprising the amino acid sequence of SEQ ID NO: 30, HVR-H2 comprising the amino acid sequence of SEQ ID NO: 31, HVR-H3 comprising the amino acid sequence of SEQ ID NO: 32, HVR-L1 comprising the amino acid sequence of SEQ ID NO: 27, HVR-L2 comprising the amino acid sequence of SEQ ID NO: 28, and HVR-L3 comprising the amino acid sequence of SEQ ID NO: 29;
b) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 60, HVR-H2 comprising the amino acid sequence of SEQ ID NO: 61, HVR-H3 comprising the amino acid sequence of SEQ ID NO: 62, HVR-L1 comprising the amino acid sequence of SEQ ID NO: 57, HVR-L2 comprising the amino acid sequence of SEQ ID NO: 58, and HVR-L3; comprising the amino acid sequence of SEQ ID NO: 59;
c) a heavy chain variable domain (VH) sequence of SEQ ID NO: 6 and a light chain variable domain (VL) sequence of SEQ ID NO: 5;
d) a VH sequence of SEQ ID NO: 8 and a VL sequence of SEQ ID NO: 7;
e) a VH sequence of SEQ ID NO: 10 and a VL sequence of SEQ ID NO: 9;
f) a VH sequence of SEQ ID NO: 12 and a VL sequence of SEQ ID NO: 11;
g) a VH sequence of SEQ ID NO: 14 and a VL sequence of SEQ ID NO: 13;
h) a VH sequence of SEQ ID NO: 16 and a VL sequence of SEQ ID NO: 15;
i) a VH sequence of SEQ ID NO: 18 and a VL sequence of SEQ ID NO: 17;
j) a VH sequence of SEQ ID NO: 20 and a VL sequence of SEQ ID NO: 19; or
k) a VH sequence of SEQ ID NO: 26 and a VL sequence of SEQ ID NO: 25.
US Pat. No. 10,244,724

SOYBEAN VARIETY 01064667

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 01064667, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124966.
US Pat. No. 10,244,725

MAIZE INBRED PH42KS

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH42KS, representative seed of the variety having been deposited under ATCC accession number PTA-124768.
US Pat. No. 10,246,518

NUCLEIC ACIDS ENCODING BISPECIFIC ANTIBODIES BINDING TO BETA-KLOTHO AND FIBROBLAST GROWTH FACTOR RECEPTOR 1

Genentech, Inc., South S...

1. A nucleic acid encoding a bispecific antibody, or an antigen-binding portion thereof, that binds to beta-Klotho (KLB) and Fibroblast Growth Factor Receptor 1c (FGFR1c), wherein the bispecific antibody, or an antigen-binding portion thereof, comprises:(i) a first arm comprising (a) a heavy chain variable region CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 136; (b) a heavy chain variable region CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 137; (c) a heavy chain variable region CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 138; (d) a light chain variable region CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 139; (e) a light chain variable region CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 140; and (f) a light chain variable region CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 141; and
(ii) a second arm comprising (a) a heavy chain variable region CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 15; (b) a heavy chain variable region CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 31; (c) a heavy chain variable region CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 47; (d) a light chain variable region CDR1 domain comprising the amino acid sequence set forth in SEQ ID NO: 62; (e) a light chain variable region CDR2 domain comprising the amino acid sequence set forth in SEQ ID NO: 78; and (f) a light chain variable region CDR3 domain comprising the amino acid sequence set forth in SEQ ID NO: 93.
US Pat. No. 10,246,519

NSP4 INHIBITORS AND METHODS OF USE

Genentech, Inc., South S...

1. An isolated nucleic acid encoding an anti-NSP4 antibody comprising a heavy chain and a light chain, wherein the light chain comprises an HVR-L1 comprising the sequence of SEQ ID NO:19, an HVR-L2 comprising the sequence of SEQ ID NO:11, and an HVR-L3 comprising the sequence of SEQ ID NO:12; and wherein the heavy chain comprisesan HVR-H1 comprising the sequence of SEQ ID NO:56, an HVR-H2 comprising the sequence of SEQ ID NO:57, and an HVR-H3 comprising the sequence of SEQ ID NO:58.
US Pat. No. 10,245,244

PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

HEART BIOTECH PHARMA LIMI...

1. A pharmaceutical formulation comprising polymeric nanoparticles encapsulated within crosslinked polymeric microparticles, wherein the polymeric nanoparticles carry a therapeutic agent suitable for treatment of pulmonary arterial hypertension (PAH) loaded within them, wherein the therapeutic agent is selected from the group consisting of a prostacyclin synthetic analog, PPAR ? agonist, and NO donor, wherein the polymeric nanoparticles comprise a chitosan-derivative polymer selected from the group consisting of chitosan-PEG-Cholanic acid, chitosan-PEG-Stearic acid, and chitosan-PEG-Oleic acid, and wherein the PEG component of the polymer is connected to the chitosan component of the polymer by an ester bond, and wherein both the PEG component and the fatty acid component are connected to the same monosaccharide ring of the chitosan.
US Pat. No. 10,246,524

METHOD FOR PREPARING SULFOBUTYL ETHER-?-CYCLODEXTRIN

ASYMCHEM LABORATORIES (TI...

1. A method for preparing sulfobutyl ether-?-cyclodextrin, the method consisting of specific preparation steps are as follows:Step (1): synthesis reaction: controlling the temperature at 20° C. to 30° C., adding an ether solvent and a sodium hydroxide aqueous solution having a concentration of 3.7 N into a reaction flask, increasing the temperature to 60° C. to 70° C., adding a ?-cyclodextrin into the reaction flask; dropping an 1,4-sulfobutyrolactone to the reaction solution at 70° C. to 75° C., stirring the reaction solution at 70° C. to 75° C. after the dropping, controlling the reaction solution at pH>9 by adding a second sodium hydroxide aqueous solution having a concentration of 3.7 N, reducing the temperature to 20° C. to 25° C. when the percentage of unreacted ?-cyclodextrin accounts for less than 0.5% wt of the total input of the ?-cyclodextrin as measured by High Performance Liquid Chromatography, then adjusting the reaction solution to pH=7.0 to 7.5 with a concentrated hydrochloric acid, and providing an obtained mixed reaction solution in a purification operation in the next step directly;
Step (2): purification: controlling the temperature at 20° C. to 30° C., adding the mixed reaction solution obtained in Step (1) into a dialysis bag, performing ultrasonic dialysis until the content of chloride ions is less than 10 ppm, decolorizing the dialysate by an absorbent active carbon, followed by filtrating to obtain a filtrate having ultraviolet absorption less than 0.5 AU, washing the active carbon twice by deionized water of 1 to 2 ml/g of the total input of the ?-cyclodextrin, combining wash solution with the filtrate, concentrating the combined wash solution and filtrate by a 0.65 to 0.22 ?m filter until the percentage of the sulfobutyl ether-?-cyclodextrin accounts for 30 wt % to 35 wt % of the total amount of the final solution, performing freeze-drying to obtain the sulfobutyl ether-?-cyclodextrin, and measuring an average 6.7 degree of substitution of the sulfobutyl ether group in capillary electrophoresis the amount of the ether solvent is 0.02 to 0.20 ml/g of the ?-cyclodextrin.
US Pat. No. 10,246,528

CHROMIUM (III) CATALYST SYSTEMS WITH ACTIVATOR-SUPPORTS

Chevron Phillips Chemical...

1. An olefin polymerization process, the process comprising:(i) combining a chromium (III) compound with an activator-support comprising a solid oxide treated with an electron-withdrawing anion to form a mixture;
(ii) subjecting the mixture to a non-oxidizing atmosphere at a peak temperature to produce a supported chromium catalyst; and
(iii) contacting the supported chromium catalyst and a co-catalyst with ethylene and an optional olefin comonomer in a polymerization reactor system under polymerization conditions to produce an ethylene polymer, wherein a molar ratio of co-catalyst:chromium is in a range from about 50:1 to about 500:1; and
wherein the ethylene polymer has a melt index in a range from 0 to about 0.5 g/10 min, and a Mw in a range from about 400,000 to about 900,000 g/mol.
US Pat. No. 10,246,784

DECREASING CORROSION ON METAL SURFACES WITH APATITE FORMING COMPONENTS

Baker Hughes, a GE compan...

1. A method for decreasing corrosion to a metal surface in an oil production system, wherein the method comprises:circulating an aqueous-based fluid comprising apatite forming components into an oil production system;
contacting at least one metal surface within the oil production system with the apatite forming components; and
forming at least one apatite species selected from the group consisting of fluoroapatite, chloroapatite, and combinations thereof on the at least one metal surface with the apatite forming components;
wherein less corrosion occurs to at least one metal surface as compared to an otherwise identical method without the contact of at least one metal surface with the apatite forming components.
US Pat. No. 10,246,788

ELECTROLYTIC GENERATION OF MANGANESE (III) IONS IN STRONG SULFURIC ACID USING AN IMPROVED ANODE

MacDermid Acumen, Inc., ...

1. An electrolytic cell comprising:an electrolyte solution comprising manganese(III) ions in a solution of acid;
a cathode in contact with the electrolyte solution; and
an anode in contact with the electrolyte solution, wherein the anode comprises a material selected from the group consisting of vitreous carbon, reticulated vitreous carbon, woven carbon fibers, and combinations of one or more of the foregoing.
US Pat. No. 10,245,253

PHARMACEUTICAL COMBINATION COMPRISING A SELECTIVE S1P1 RECEPTOR AGONIST

ACTELION PHARMACEUTICALS ...

1. A pharmaceutical combination comprising a first active ingredient which is (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically acceptable salt thereof and a second active ingredient which is dimethyl fumarate.
US Pat. No. 10,246,791

ELECTRODEPOSITION MEDIUMS FOR FORMATION OF PROTECTIVE COATINGS ELECTROCHEMICALLY DEPOSITED ON METAL SUBSTRATES

General Cable Technologie...

1. An article comprising:an electrically conductive metal substrate and a protective coating, the protective coating electrochemically deposited from an electrodeposition medium comprising:
a silicon alkoxide;
one or more quaternary ammonium compounds or quaternary phosphonium compounds, wherein the one or more quaternary ammonium compounds or quaternary phosphonium compounds are selected from the group consisting of tetra butyl ammonium hydroxide, benzyl triethyl ammonium hydroxide, tetra ethyl ammonium hydroxide, tetra methyl ammonium hydroxide, benzyl trimethyl ammonium hydroxide, trimethyl hydroxyethyl ammonium hydroxide, tetra butyl phosphonium hydroxide, benzyl triethyl phosphonium hydroxide, tetra ethyl phosphonium hydroxide, tetra methyl phosphonium hydroxide, benzyl trimethyl phosphonium hydroxide, and trimethyl hydroxyethyl phosphonium hydroxide; and
water;
wherein the article is at least one of one or more electrically conductive wires in an overhead conductor.
US Pat. No. 10,246,542

ATACTIC POLYPROPYLENE COMB BLOCK POLYOLEFINS USEFUL AS MODIFIERS IN POLYOLEFINS AND HYDROCARBONS

ExxonMobil Chemical Paten...

1. A process for preparing comb-block polyolefins comprising:contacting, at a temperature within a range from 20 to 70° C., propylene with a first metallocene precursor and an activator to form vinyl-terminated atactic polypropylene having a weight average molecular weight of at least 8000 g/mole and a crystallinity of less than 20%;
contacting in a subsequent step, at a temperature within a range from 40 to 150° C., the vinyl-terminated atactic polypropylene with ethylene, propylene, or both, a second metallocene precursor, and an activator to form a comb-block polyolefin; and
forming in said subsequent step a linear low molecular weight component (LLMW) comprising ethylene or ethylene/propylene copolymers and having a number average molecular weight within a range from 7,000 to 50,000 g/mole,
wherein the comb-length of the comb-block polyolefin is greater than the entanglement molecular weight of atactic polypropylene.
US Pat. No. 10,245,269

SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR

Epizyme, Inc., Cambridge...

1. A method of inhibiting the histone methyltransferase activity of EZH2 in a subject in need thereof comprising administering to the subject an effective amount of a solid crystalline form of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4?-(morpholinomethyl)-[1,1?-biphenyl]-3-carboxamide hydrobromide, wherein the solid crystalline form exhibits an X-ray powder diffraction pattern having one or more characteristic peaks expressed in degrees 2-theta at about 3.9+/?0.3 degrees, about 17.5+/?0.3 degrees, and about 22.0+/?0.3 degrees 2-theta.
US Pat. No. 10,245,274

CHITOSAN-BASED MATRICES AND USES THEREOF

THE TRUSTEES OF THE UNIVE...

1. A method of treating an otorhinolaryngology-associated pathology, or Head and Neck associated pathology in a subject, comprising administering through the auditory bulla a composition onto the round window membrane of the subject for release of an agent to the perilymph of the inner ear of the subject, wherein said composition comprises a solution of chitosan-glycerophosphate (CGP) and the agent, wherein the agent dissolved therein is present in an amount effective in the treatment of the otorhinolaryngology-associated pathology, or Head and Neck associated pathology, wherein auditory functions are preserved by said administering.
US Pat. No. 10,245,276

CO-CRYSTALS OF TRAMADOL AND COXIBS

LABORATORIOS DEL DR. ESTE...

1. A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it has an orthorhombic unit cell with the following dimensions:a=11.0323(7) ?
b=18.1095(12) ?
c=17.3206(12) ?.
US Pat. No. 10,245,278

LIQUID OR SEMI-LIQUID PHARMACEUTICAL, DIETARY OR FOOD COMPOSITION FREE OF BITTERNESS CONTAINING AN ARGININE SALT

2. A liquid or semi-liquid, aqueous dietary, pharmaceutical composition, comprising at least one salt of L-arginine in an amount of at least one gram of said salt per unit dose, said composition comprising:from 15 to 30% by weight of L-arginine salt,
from 15 to 45% by weight of maltitol, and
from 0.1% to 12% by weight of an alcohol or of an alcoholate, relative to the total weight of the composition.
US Pat. No. 10,246,560

PLGA-MODIFIED POLYETHYLENIMINE SELF-ASSEMBLY NANOTECHNOLOGY FOR NUCLEIC ACID AND DRUG DELIVERY

Baylor College of Medicin...

1. A composition comprising a copolymer consisting of lactide-co-glycolide and PEI, wherein single lactide-co-glycolide units are each conjugated to primary amines of PEI through an amide linkage, wherein the w/w ratio of LGA to PEI is 0.5:1 to 5:1,wherein the composition further comprises at least one therapeutic and/or diagnostic agent and wherein the composition is in the form of a nanoparticle.
US Pat. No. 10,245,283

COMPOSITIONS AND METHODS TO AFFECT SKIN IRRITATION

ALUMEND, LLC, Sioux Fall...

1. A sunscreen composition comprising: (a) at least one sunscreen agent that causes skin irritation and/or skin inflammation and/or IL-1? secretion, and (b) at least one chitosan covalently modified with an octane sulfonic acid via a sulfonamide linkage, wherein the composition provides a reduction in skin irritation and/or a reduction in skin inflammation and/or a reduction in irritant-induced IL-1? secretion after contact with the composition compared with a control composition comprising the sunscreen agent but not the chitosan.
US Pat. No. 10,246,821

IN-LINE DIGITAL PRINTING SYSTEM FOR TEXTILE MATERIALS

Kornit Digital Ltd., Ros...

1. A digital inkjet printing system for digitally printing an image onto a substrate, comprising at least one inkjet printhead for applying a digital ink, and at least one applicator for applying a base application, said digital ink and said base application being kept separate from each other until discharged toward or upon a receiving surface of the substrate, wherein said base application comprises:between about 30% to about 70% by weight of an aqueous acrylic latex material;
between about 2.5% to about 20% by weight of one or more acrylic resin dispersions;
between about 5% to about 20% by weight of one or more coalescing agents; and
between about 0 to about 40% by weight of a pigment dispersion, said one or more acrylic resins are separate from said latex material, and said acrylic latex material is characterized by a minimum film-forming temperature that ranges from ?10° C. to 50° C.
US Pat. No. 10,246,567

POLYOLEFIN MICROPOROUS FILM

ASAHI KASEI E-MATERIALS C...

1. A biaxially stretched polyolefin microporous film, having a compression elastic modulus of 0.1 to 50 kPa, and a ratio of a tensile elastic modulus in a longitudinal direction to a tensile elastic modulus in a transverse direction of 1.5 to 7.8, whereina tensile strength at break in the transverse direction of the biaxially stretched polyolefin microporous film is 50 MPa or more and 500 MPa or less,
an average pore diameter of the polyolefin microporous film is 0.06 to 0.09 ?m, and wherein an air permeability of the biaxially stretched polyolefin microporous film is in the range of 10 sec/100 cc to 500 sec/100 cc.
US Pat. No. 10,245,289

TREATMENT AND PROPHYLAXIS FOR LUPUS

NuBiome, Inc., Mountain ...

1. A method of mitigating or treating Lupus comprises:administering an effective amount of a medicament to the gastrointestinal tract of a human comprised of Lactobacillus bulgaricus B-30892 and/or a supernatant resulting from culturing Lactobacillus bulgaricus B-30892 and/or bioactive materials resulting from culturing Lactobacillus bulgaricus B-30892 to mitigate or treat Lupus.
US Pat. No. 10,245,300

GLUTEN-RELATED DISORDERS

H.J. Heinz Company Brands...

1. A method of treating a subject having a gluten-related disorder, the method comprising:administering to the subject an effective amount of a composition comprising a probiotic bacterium Lactobacillus paracasei CBA L74, deposited at the Belgian Coordinated Collections of Micro-organisms (BCCM) Laboratorium voor Microbiologie (LMG) and having International Depository Accession Number LMG P-24778, wherein the probiotic bacterium reduces a symptom of gliadin peptide toxicity.
US Pat. No. 10,245,305

BOTULINUM TOXIN THERAPY FOR SKIN DISORDERS

Allergan, Inc., Irvine, ...

1. A method for reducing the occurrence or alleviating a melanin related affliction in a patient in need thereof, the method comprising the step of locally administering a therapeutically effective amount of a botulinum toxin to an area affected by the melanin related affliction, thereby reducing the occurrence or alleviating the melanin related affliction, wherein the melanin related affliction is selected from the group consisting of dermatofibromas, freckles and atypical moles (dysplastic nevi).
US Pat. No. 10,249,403

P(CN)3 REACTIONS WITH LITHIUM DICYNAMIDE PRODUCING METALATED CARBON PHOSPHONITRIDE EXTENDED SOLIDS

The United States of Amer...

1. A method of making a lithiated carbon phosphonitride material, the method comprising:reacting P(CN)3 with LiN(CN)2 in solution, then
drying the solution to obtain a material comprising lithiated carbon phosphonitride.
US Pat. No. 10,245,307

PREVENTION AND REDUCTION OF BLOOD LOSS

Dyax Corp., Lexington, M...

1. A method for inhibiting plasma kallikrein in a patient in need thereof comprising,administering to the patient a composition comprising a pharmaceutically acceptable carrier and a polypeptide comprising the amino acid sequence: Xaa1 Xaa2 Xaa3 Xaa4 Cys Xaa6 Xaa7Xaa8 Xaa9 Xaa10 Xaa11 Gly Xaa13 Cys Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Xaa21 Xaa22Xaa23 Xaa24 Xaa25 Xaa26 Xaa27 Xaa28 Xaa29 Cys Xaa31 Xaa32 Phe Xaa34 Xaa35 Gly Gly Cys Xaa39 Xaa40 Xaa41 Xaa42 Xaa43 Xaa44 Xaa45 Xaa46 Xaa47 Xaa48 Xaa49 Xaa50 Cys Xaa52Xaa53 Xaa54 Cys Xaa56 Xaa57 Xaa58 (SEQ ID NO:1), wherein
Xaa1, Xaa2, Xaa3, Xaa4, Xaa56, Xaa57 or Xaa58 are each individually an amino acid or absent;
Xaa6, Xaa7, Xaa8, Xaa9, Xaa20, Xaa24, Xaa25, Xaa26, Xaa27, Xaa28, Xaa29, Xaa41, Xaa42, Xaa44, Xaa46, Xaa47, Xaa48, Xaa49, Xaa50, Xaa52, Xaa53, and Xaa54 are each any amino acid;
Xaa10 is Asp;
Xaa11 is an amino acid selected from the group consisting of: Asp, Gly, Ser, Val, Asn, Ile, Ala and Thr;
Xaa13 is an amino acid selected from the group consisting of: Arg, His, Pro, Asn, Ser, Thr, Ala, Gly, Lys and Gln;
Xaa15 is an amino acid selected from the group consisting of: Arg, Lys, Ala, Ser, Gly, Met, Asn and Gln;
Xaa16 is an amino acid selected from the group consisting of: Ala, Gly, Ser, Asp and Asn;
Xaa17 is an amino acid selected from the group consisting of: Ala, Asn, Ser, Ile, Gly, Val, Gln and Thr;
Xaa18 is an amino acid selected from the group consisting of: His, Leu, Gln and Ala;
Xaa19 is an amino acid selected from the group consisting of: Pro, Gln, Leu, Asn and Ile;
Xaa21 is an amino acid selected from the group consisting of: Trp, Phe, Tyr, His and Ile;
Xaa22 is an amino acid selected from the group consisting of: Tyr and Phe;
Xaa23 is an amino acid selected from the group consisting of: Tyr and Phe;
Xaa31 is an amino acid selected from the group consisting of: Glu, Asp, Gln, Asn, Ser, Ala, Val, Leu, Ile and Thr;
Xaa32 is an amino acid selected from the group consisting of: Glu, Gln, Asp Asn, Pro, Thr, Leu, Ser, Ala, Gly and Val;
Xaa34 is an amino acid selected from the group consisting of: Ile, Asn, and Leu;
Xaa35 is an amino acid selected from the group consisting of: Tyr, Trp and Phe;
Xaa39 is an amino acid selected from the group consisting of: Glu, Gly, Ala, Ser and Asp;
Xaa40 is an amino acid selected from the group consisting of: Gly and Ala;
Xaa43 is an amino acid selected from the group consisting of: Asn and Gly;
Xaa45 is an amino acid selected from the group consisting of: Phe and Tyr;
and wherein the polypeptide inhibits kallikrein.
US Pat. No. 10,245,309

ANTIGEN SPECIFIC MULTI EPITOPE-BASED ANTI-INFECTIVE VACCINES

Lior Carmon, Tel Aviv (I...

1. A method of treating a pathogenic infection in a subject in need thereof, comprising administering to the subject any one of:(i) an immunogenic composition comprising at least one peptide comprising a signal peptide domain of at least one target protein of said pathogen, wherein said peptide is not longer than 40 amino acids;
(ii) an enriched T cell population obtained by administering an immunogenic composition comprising at least one peptide comprising a signal peptide domain of at least one target protein of said pathogen to a T cell population in vitro, wherein said peptide is not longer than 40 amino acids.
US Pat. No. 10,246,589

ANTI-ICING ADDITIVE COMPOSITION FOR BITUMINOUS CONGLOMERATES

ITERCHIMICA S.R.L., Suis...

1. An ani-icing composition suitable for incorporation in bituminous conglomerates for road paving, comprising an alkali metal chloride, an alkaline-earth metal carbonate, an alkali or alkaline-earth metal formate, a polysiloxane and optionally an alkaline-earth metal chloride, in which the polysiloxane is contained in an amount between 0.5 and 2.0% by weight of the total weight of the composition.
US Pat. No. 10,245,313

DNA MOTIF COMPOUNDS AND METHODS FOR INDUCING SPECIFIC ANTIBODIES AND CELLULAR IMMUNITY

VERSITECH LIMITED, Hong ...

1. An immunogenic composition comprising:a mixture of different plasmids, each of which encodes a motif peptide comprising the sequence xxxxxNCSFNITTxxxx (SEQ ID NO: 1), wherein x stands for any amino acid residue, and wherein the x residues flanking NCSFNITT motif are different when compared to another plasmid in the mixture.
US Pat. No. 10,246,337

SAFE AND LOW TEMPERATURE THERMITE REACTION SYSTEMS AND METHOD TO FORM POROUS SILICON

Battelle Memorial Institu...

1. A method for preparing porous silicon, comprising:forming a mixture comprising (i) porous silica, (ii) a metal comprising aluminum, magnesium, or a combination thereof, and (iii) a metal halide comprising a metal M, where the metal M is Ti, Zn, Ga, Ge, Aq, Sn, Sb, Au, Hq, Tl, Bi, or a combination thereof, and the metal halide has a melting point ?400° C.;
heating the mixture in a sealed vessel at a temperature greater than or equal to the melting point of the metal halide and ?400° C. under an inert atmosphere to form a product comprising porous silicon; and
combining the product with acid to remove any by-products from the porous silicon.
US Pat. No. 10,246,338

PROCESS FOR PREPARING PRECIPITATED SILICA USING A MIXER OR EXTRUDER

Rhodia Operations, Paris...

1. A process for preparing a precipitated silica, the process comprising:reacting a silicate with an acidifying agent to obtain a suspension of precipitated silica (S1), followed by separation to obtain a cake having a dry matter content of at least 25% by weight,
compacting the cake at a pressure higher than 10 bars and lower than 60 bars;
disintegrating the cake to obtain a suspension of precipitated silica (S2) by mixing in a twin-screw mixer or by extrusion, and
drying the suspension of precipitated silica (S2).
US Pat. No. 10,245,320

IMMUNOMODULATORY PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Enzo Biochem, Inc., New ...

1. An immunomodulatory pharmaceutical composition comprising:(a) at least substantially pure alpha-synuclein protein; and
(b) at least one preselected antigen or immunogen, which is not a human or non-human mammalian alpha-synuclein protein or a fragment thereof.
US Pat. No. 10,246,606

TRANSPARENT FLEXIBLE HARD COATED FILM AND METHOD OF PRODUCING THE SAME

KOREA ADVANCED INSTITUTE ...

1. An ionic polymerizable siloxane hard coating composition for forming a transparent flexible hard coated film, the composition comprising:oligosiloxane [component (A)] having on average at least one alicyclic epoxy group per molecule;
a reactive diluent [component (B)] that is (3,4-epoxycyclohexyl)methyl 3,4-epoxycyclohexylcarboxylate or that has on average at least one oxetane group per molecule; and
an ionic polymerization initiator [component (C)],
wherein the ionic polymerizable siloxane hard coating composition is produced by a method including mixing the component (C) of from 0.1 part by weight to 10 parts by weight with respect to 100 parts by weight of the component (A),
wherein the component (A) has an average unit chemical formula represented by the following Chemical Formula 1:
(R1SiO3/2)a(R22SiO2/2)b(R33SiO1/2)c(SiO4/2)d(R4O1/2)e,  [Chemical Formula 1]
wherein in Chemical Formula 1,
R1 is an alicyclic epoxy group, and R2 and R3 are each independently selected from the group consisting of a substitutable C1-20 alkyl group, a substitutable C2-20 alkenyl group, a substitutable C2-20 alkynyl group, and a substitutable C6-20 aryl group, a substitutable substituent in the R2, and R3 is at least one member selected from the group consisting of a C1-20 alkyl group, a C3-8 cycloalkyl group, a C1-20 alkoxy group, an amino group, an acryl group, a (meth)acryl group, halogen, an allyl group, a mercapto group, an ether group, an ester group, a carbonyl group, a carboxyl group, a vinyl group, a nitro group, a sulfone group, a hydroxyl group, a cyclobutene group, an alkyd group, an urethane group, an oxetane group, a phenyl group, and combinations thereof,
R4 is a straight or branched C1-7 alkyl group or hydrogen,
a is a positive number,
b is 0 or a positive number,
c is 0 or a positive number,
d is 0 or a positive number,
e is 0 or a positive number,
(b+c+d)/a is a number of from 0 to 1,
e/(a+b+c+d) is a number of from 0 to 0.4, and
the alicyclic epoxy group is not a glycidyl group.
US Pat. No. 10,246,607

RESIN COMPOSITION, COATING COMPOSITION AND ARTICLE BY USING THE SAME

CHANG CHUN PLASTICS CO., ...

1. A resin composition comprising:a component (i): an epoxy resin comprising an epoxidized tricyclo decanedimethanol, and
a component (ii): an epoxy resin comprising an epoxidized cardanol.
US Pat. No. 10,246,609

PIGMENTED COATING MATERIAL AND PROCESS FOR PRODUCING A MULTI-COAT PAINT SYSTEM USING THE PIGMENTED COATING MATERIAL

BASF Coatings GmbH, Muen...

1. A solvent-based pigmented coating composition comprising(A) at least one binder comprising at least one acrylate polymer, polyurethane polymer, or polyester,
(B) at least one crosslinking agent selected from the group of blocked polyisocyanates and amino resins,
(C) at least one pigment, and
(D) at least one organic solvent that is n-pentyl acetate, n-pentyl glycol, or n-hexyl glycol,
wherein the solids content of the coating composition is at least 35% by weight.
US Pat. No. 10,246,610

COATING COMPOSITION

PPG Industries Ohio, Inc....

1. A coating composition comprising a resin material comprising a polyester imide polymer; one or more titanate material; one or more OH reactive cross linking material and one or more acidic polyester material.
US Pat. No. 10,246,612

ADHESIVE TAPE

LG Chem, Ltd., (KR)

1. An adhesive tape for use in bonding of a TV bezel, sequentially comprising:a first adhesive layer;
an inner polyurethane foamed layer, having a density of 0.1 g/cm3 to 0.5 g/cm3; and
a second adhesive layer,
wherein the polyurethane foamed layer has pores with an average diameter of 50 microns to 200 microns,
wherein the polyurethane foamed layer has a thickness of 0.2 mm to less than 5.0 mm; and
wherein the adhesive tape has a width of 1 mm to 7 mm,
wherein the polyurethane foamed layer has a compressive strength of 100 gf/in2 to 2000 gf/in2,
wherein the polyurethane foamed layer has a tensile strength of 2 kgf/in2 to 20 kgf/in2, and
wherein the adhesive layers comprise at least one of acrylic adhesives, rubber adhesives, silicone adhesives, or combinations thereof.
US Pat. No. 10,246,622

COOLANT HAVING RAPID METAL PASSIVATION PROPERTIES

Arteco NV, Schoten (BE)

1. A heat transfer solution which provides passivation when placed in contact with metal surfaces, said solution comprising:(a) water, an alcohol, or a mixture of both;
(b) from 0.01 to 1 wt % of a nitrite;
(c) from 0.0001 to 1 wt % of a phosphonate or a phosphinate,
the phosphonate having the formula R—[CR2]m—PO3M2 wherein each R-group is selected from the group consisting of hydrogen, alkyl, alkenyl, hydroxyl, phosphono group, carbonyl group, amino, alkylamino and an aryl group, wherein m is 1 or an integer greater than 1, and each M is hydrogen or an alkali metal ion;
the phosphinate having the formula R—[CR2]m—P(O2M)H wherein each R-group is selected from the group consisting of hydrogen, alkyl, alkenyl, hydroxyl, phosphino group, carbonyl group, amino, alkylamino and an aryl group, wherein m is 1 or an integer greater than 1, and M is hydrogen or an alkali metal ion;
(d) an alkaline earth metal compound; and
(e) a corrosion inhibitor selected from the group consisting of 2-ethylhexanoic acid, sebacic acid, and mixtures thereof,
wherein the heat transfer solution is free of inorganic phosphates.
US Pat. No. 10,246,371

ARTICLES INCLUDING GLASS AND/OR GLASS-CERAMICS AND METHODS OF MAKING THE SAME

CORNING INCORPORATED, Co...

1. An article, comprising:SiO2 from about 40 mol % to about 80 mol %;
Al2O3 from about 1 mol % to about 20 mol %;
B2O3 from about 3 mol % to about 50 mol %;
WO3 plus MoO3 from about 1 mol % to about 18 mol %, wherein WO3 is about 1.0 mol % or greater;
at least one of: (i) Au from about 0.001 mol % to about 0.5 mol %, (ii) Ag from about 0.025 mol % to about 1.5 mol %, and (iii) Cu from about 0.03 mol % to about 1 mol %;
a plurality of crystalline precipitates comprising an oxide of the chemical form MxWO3 or MxMoO3, wherein M is one or more of H, Li, Na, K, Rb, Cs, Ca, Sr, Ba, Zn, Ag, Au, Cu, Sn, Cd, In, Tl, Pb, Bi, Th, La, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm, Yb, Lu, and U, and wherein 0 R2O from about 0 mol % to about 15 mol %, wherein the R2O is one or more of Li2O, Na2O, K2O, Rb2O and Cs2O,
wherein R2O minus Al2O3 ranges from about ?12 mol % to about 3.8 mol %.
US Pat. No. 10,245,351

MALLEABLE HYDROGEL HYBRIDS MADE OF SELF-ASSEMBLED PEPTIDES AND BIOCOMPATIBLE POLYMERS AND USES THEREOF

Technology Innovation Mom...

1. A hydrogel comprising a fibrous network of a plurality of peptides and at least one biocompatible polymer, wherein said peptides are capable of self-assembling in an aqueous solution so as to form a hydrogel, wherein each peptide in said plurality of peptides comprises an amino acid sequence not exceeding 6 amino acids in length, said amino acid sequence comprising at least one aromatic amino acid residue, and wherein said biocompatible polymer features at least one characteristic selected from the group consisting of:(i) a storage modulus G? lower than 500 Pa at 10 Hz frequency and at 25° C.;
(ii) a swelling ratio (Q) higher than 500;
(iii) a viscosity at 0.1 Sec?1 shear rate and at 25° C., lower than 300 Pa·s; and
(iv) a viscosity recovery after shear of at least 95%.
US Pat. No. 10,246,633

HIGHLY STABLE QUANTUM DOT-CONTAINING POLYMER FILMS

Nanoco Technologies Ltd.,...

1. A film comprising:a plurality of semiconductor nanoparticles dispersed in a cured inner phase that comprises lauryl methacrylate and trimethylolpropane trimethacrylate; and,
an outer phase that comprises an acrylate-functionalized silica nanoparticle resin.
US Pat. No. 10,246,380

SOLID WASTE TREATMENT METHOD

B.A.M.2 Waste Water Consu...

1. A solid waste treatment method consisting of the steps of:a. chlorinating solid waste having a first biological oxygen demand to produce degraded and sterilized solid waste and residual solid waste;
b. measuring the residual solid waste for chlorine residuals, and if residual chlorine is:
i) present, dechlorinating the residual solid waste to produce dechlorinated residual solid waste; or
ii) not present, determining that the residual solid waste is dechlorinated residual solid waste;
c. adding a flocculating composition to the dechlorinated residual solid waste to solubilize the dechlorinated residual solid waste;
d. inoculating the dechlorinated residual solid waste with bacteria, selected from the group of aerobic bacteria, facultative bacteria and combinations thereof, wherein the bacteria biodegrade the dechlorinated residual solid waste.
US Pat. No. 10,246,644

METHOD FOR PREPARING BIODIESEL

Tsinghua University, Bei...

1. A method for preparing biodiesel, wherein said method comprises steps of:(1) adding oil and fat, short chain alcohol, water, and liquid lipase into a single-stage or multi-stage reactor for conducting a reaction, then separating the reaction liquid into a heavy phase and a light phase; recovering and reusing the liquid lipase in the heavy phase, and using the light phase for subsequent conversion by immobilized lipase;
(2) flowing the light phase obtained in step (1) into a single-stage or multi-stage reactor containing immobilized lipase, and adding short chain alcohol for conducting a reaction; wherein an online dehydration is carried out during the whole reaction or part of the reaction.
US Pat. No. 10,246,396

VANILLIN HAVING TETRAMER STRUCTURE

1. A vanillin having a tetramer structure, comprising a first monomer, a second monomer, a third monomer, a fourth monomer, a first intermolecular hydrogen bond between the first monomer and the fourth monomer, and a second intermolecular hydrogen bond between the second monomer and the third monomer; wherein each of the monomers is constituted by C8H8O3.
US Pat. No. 10,245,887

METHODS RELATING TO POLYURETHANE FOAM-CONTAINING AND DEGRADABLE FOAM-CONTAINING TIRES, AND DEGRADABLE FOAM-CONTAINING TIRES

Bridgestrone Americas Tir...

1. A method for degrading polyurethane foam from inside of a mounted polyurethane foam-containing tire, the method comprising:a. providing a solution comprising at least one phosphorous oxoacid or an ester thereof,
b. providing a mounted tire comprising a wheel and a rubber carcass and having polyurethane foam inside the rubber carcass,
c. applying the solution to the polyurethane foam inside the rubber carcass, and
d. heating to degrade the polyurethane foam.
US Pat. No. 10,245,888

RUBBER COMPOSITION FOR TIRES AND PNEUMATIC TIRE

SUMITOMO RUBBER INDUSTRIE...

1. A pneumatic tire, comprising a tire component formed from a rubber composition for tires, the rubber composition comprising;a rubber component and
a core-shell structured particle comprising a core and a shell,whereinthe core has a melt viscosity at 38° C. of 0.1 to 3,000 Pa·s, and
the shell is formed of a polymer of at least one of a conjugated diene compound or an aromatic vinyl compound.
US Pat. No. 10,246,668

PROPORTIONER-READY BIOENZYMATIC CONCENTRATED CLEANING PRODUCT

Illinois Tool Works, Inc....

1. A bioenzymatic, concentrated cleaning product, comprising:15 to 55% by weight bacillus spores, capable of generating extracellular enzymes selected from the group consisting of extracellular protease enzymes, extracellular urease enzymes, extracellular amylase enzymes, extracellular lypase enzymes, extracellular cellulase enzymes, and combinations thereof;
a suspending and/ or rheology modifying agent;
an odor control agent;
sufficient pH adjuster to maintain a pH of about 5.0 to about 9.5;
and water;
wherein the 15-55% by weight bacillus spores have an average diameter of 5-50microns and remain suspended in the water under static conditions and the bioenzymatic, concentrated cleaning product is substantially free of organic solvents.
US Pat. No. 10,249,486

METHOD FOR POLISHING SEMICONDUCTOR SUBSTRATE

NITTA HAAS INCORPORATED, ...

1. A method for polishing a semiconductor substrate, comprising:an intermediate polishing step if polishing in such a way that the number of surface defects having heights of less than 3 nm becomes 45% or more of the total number of the surface defects on the surface of a semiconductor substrate; and
a final polishing step of finish-polishing the semiconductor substrate after the intermediate polishing step,
wherein in the intermediate polishing step, polishing is performed by using a polishing composition comprising: hydroxyethyl cellulose, water and abrasive grains, the hydroxyethyl cellulose has a molecular weight of 500,000 or more and 1,500,000 or less, and the mass ratio of the hydroxyethyl cellulose to the abrasive grains is 0.0075 or more and 0.025 or less, and
wherein in the final polishing step, polishing is performed by using a polishing composition comprising: hydroxyethyl cellulose, water and abrasive grains, and the hydroxyethyl cellulose has a molecular weight of 300,000 or more and 1,200,000 or less, and has a different molecular weight from that of the hydroxyethyl cellulose present in the polishing composition used in the intermediate polishing step.
US Pat. No. 10,246,677

DEVICES, SYSTEMS AND METHODS FOR THE PRODUCTION OF HUMANIZED GUT COMMENSAL MICROBIOTA

1. A system for the ex vivo production of human gut microbiota, comprising:a tortuous, tubular ex vivo culture network comprising-hollow cartridges for culturing human gut microbiota, wherein the hollow cartridges are in the fluid communication and removably attached to the tortuous tubular ex vivo culture network and comprise human gut microbiota and metabolites;
a humidifying system in fluid communication with the tortuous tubular ex vivo culture network to maintain physiological humidity inside the tortuous tubular ex vivo culture network;
a temperature regulation system in contact with the tortuous tubular ex vivo culture network to regulate the temperature inside the tortuous tubular ex vivo culture network to physiological temperature; and
a hollow functional screening portal comprising extracellular matrix proteins, human cells, and metabolites generated by the microbiota in the tortuous tubular ex vivo culture network, wherein the screening portal receives oxygen and other gases for culturing the human cells from a gas system in fluid communication with the tortuous tubular ex vivo culture network, wherein the functional screening portal is separated from the microbiota column with a semi-permeable membrane; and
a tunable, gas gradient of 0.8-2.0% oxygen or 2-60 mm Hg in the tortuous tubular ex vivo culture network.
US Pat. No. 10,246,678

BIOMATRIX SCAFFOLDS

The University of North C...

1. A biomatrix scaffold produced by a method comprising:a) perfusing the biological tissue or homogenizing the biological tissue from the group consisting of liver, lung, thyroid, skin, pancreas, blood vessels, bladder, kidneys, brain, biliary tree, duodenum, abdominal aorta, iliac vein, heart, and intestines, with a first medium, wherein the osmolality of said first medium is from about 250 mOsm/kg to about 350 mOsm/kg and said first medium is serum free and at neutral pH; then
b) perfusing the biological tissue or extracting the homogenate of step (a) with a delipidating buffer comprising lipases and/or detergents in said first medium, wherein the detergents do not comprise sodium dodecyl sulfate or Triton X-100; then
c) perfusing the tissue or extracting the homogenate of step (b) with a buffer at a neutral pH and comprising a salt concentration from about 2.0 M to about 5.0 M NaCl; then
d) rinsing the tissue or homogenate of step (c) with a second medium that is at neutral pH, is serum-free and has an osomolality from about 250 mOsm/kg to about 350 mOsm/kg,
thereby producing an intact or homogenized biomatrix scaffold from the biological tissue, said biomatrix scaffold comprising at least 95% of the collagens and most collagen-associated matrix components and matrix bound growth factors, hormones and cytokines of the biological tissue.
US Pat. No. 10,246,682

METHODS OF CULTURING RETINAL PIGMENTED EPITHELIUM CELLS, INCLUDING XENO-FREE PRODUCTION, RPE ENRICHMENT, AND CRYOPRESERVATION

The Regents of the Univer...

1. A method of producing RPE cells from pluripotent cells under xeno-free culture conditions, comprising(a) culturing pluripotent cells on a first xeno-free substrate in a xeno-free growth medium supplemented with one or more compositions which substantially maintains pluripotent cells in a pluripotent state, wherein the pluripotent cells are embryonic stem cells or induced pluripotent stem cells;
(b) replacing the xeno-free growth medium with a xeno-free growth medium lacking any composition which maintains cells in a pluripotent state, wherein the cultured cells have not reached confluence at the time of such replacement of growth medium;
(c) allowing the cultured cells on the first xeno-free substrate to undergo spontaneous differentiation, which results in some of the pluripotent cells differentiating into RPE cells;
(d) treating the cultured cells on the first xeno-free substrate with a solution comprising a dissociation agent for a first interval of time, removing the solution comprising the dissociation agent, and immediately thereafter washing the first xeno-free substrate with buffer or medium;
(e) physically separating cells other than mature RPE cells from the first xeno-free substrate;
(f) treating the cultured cells remaining on the first xeno-free substrate with a solution comprising a dissociation agent for a second interval of time;
(g) physically separating the mature RPE cells from the first xeno-free substrate to yield isolated RPE cells; and
(h) culturing the isolated RPE cells on a second xeno-free substrate in xeno-free growth medium.
US Pat. No. 10,246,428

INSENSITIVE PLASTICIZER AND MELT-CASTABLE ENERGETIC MATERIAL

The United States of Amer...

1. A method comprising:mixing dichloroglyoxime with an alcohol containing an alkyne functional group in methanol to create a mixture;
adding a salt compound and water to said mixture to create bis-isoxazole diol; and
nitrating said bis-isoxazole diol to create 3,3?-bis-isoxazole-5,5?-bis-methylene dinitrate.
US Pat. No. 10,246,693

POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

Novozymes, Inc., Davis, ...

1. A DNA construct or recombinant expression vector comprising an isolated polynucleotide comprising a nucleotide sequence that encodes a GH61 polypeptide having cellulolytic enhancing activity, wherein the isolated polynucleotide is operably linked to one or more heterologous control sequences that direct the production of the polypeptide in an expression host, and wherein the GH61 polypeptide having cellulolytic enhancing activity is selected from:(a) a GH61 polypeptide having at least 95% sequence identity to amino acids 20 to 223 of SEQ ID NO: 8; and
(b) a GH61 polypeptide encoded by a polynucleotide having at least 99% sequence identity to nucleotides 58 to 974 of SEQ ID NO: 7, or a GH61 polypeptide encoded by the cDNA of nucleotides 58 to 974 of SEQ ID NO: 7.