US Pat. No. 10,188,697

GLYCOPEPTIDE COMPOSITIONS

XELLIA PHARMACEUTICALS AP...

1. A pharmaceutical composition comprising a glycopeptide antibiotic; an excipient selected from N-acetyl-D-Alanine and N-acetyl-Glycine; and an amino acid.
US Pat. No. 10,189,979

NUCLEATED PHTHALATE-FREE PP HOMOPOLYMERS FOR MELT-BLOWN FIBERS

BOREALIS AG, Vienna (AT)...

1. A polypropylene composition suitable for the production of meltblown PP fibers comprising:(A) a propylene homopolymer, produced with a Ziegler-Natta catalyst (ZN-C), and
(B) a polymeric nucleating agent,
wherein the polypropylene composition has
i) a melt flow rate MFR2 (230° C./2.16 kg) measured according to ISO 1133 of 90 to 5000 g/10 min, and
ii) a difference between melting temperature (Tm) and crystallization temperature (Tc), (Tm?Tc) of <45° C., and
wherein the propylene homopolymer has been visbroken and has an MFR2 of 400 to 3000 g/10 min.
US Pat. No. 10,188,698

SAPOSIN C-DOPS: A NOVEL ANTI-TUMOR AGENT

1. A method for decreasing tumor volume in a subject comprising the step of administering to the subject a composition comprisinga phospholipid, wherein the phospholipid is phosphatidylserine;
an isolated saposin C-related polypeptide, wherein the polypeptide has an amino acid sequence at least 85 percent identical to SEQ ID NO: 2 and wherein the polypeptide includes amino acids 24-40 of SEQ ID NO:2; and
wherein the phospholipid forms a nanovesicle incorporating the polypeptide.
US Pat. No. 10,189,981

HIGH-STRENGTH CROSS-LINKED POLYMER PHOTONIC CRYSTAL FILM

XIAMEN UNIVERSITY, Xiame...

1. A method for preparing a cross-linked polymer photonic crystal film, comprising the steps of:(a) preparing a first emulsion by:
polymerizing a hydrophobic monomer and a hydrophilic monomer having epoxy groups in water to provide a first self-assembled unit of monodispersed polymer microspheres having a hydrophobic core and a hydrophilic shell with surface epoxy groups; and
dispersing the monodispersed polymer microspheres of the first self-assembled unit into water under normal conditions of temperature and pressure to obtain the first emulsion having a concentration of polymer microspheres ranging from 5 wt % to 30 wt %;
(b) preparing a second emulsion by:
polymerizing a hydrophobic monomer and a hydrophilic monomer having carboxyl groups or amino groups in water to provide a second self-assembled unit of monodispersed polymer microspheres having a hydrophobic core and a hydrophilic shell with surface carboxyl groups or surface amino groups; and
dispersing the monodispersed polymer microspheres of the second self-assembled unit into water under normal conditions of temperature and pressure to obtain a second emulsion having a concentration of polymer microspheres ranging from 5 wt % to 30 wt %;
(c) successively coating the first emulsion and the second emulsion onto a flat substrate in any order; and
(d) evaporating the water to enable a self-crosslinking reaction between the surface epoxy groups of the first self-assembled unit and the surface carboxyl groups or the surface amino groups of the second self-assembled unit to form said cross-linked polymer photonic crystal film.
US Pat. No. 10,188,702

METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS

THE TRUSTEES OF THE UNIVE...

1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism comprising administering to the subject an effective amount of a peptide wherein the amino acid sequence of the peptide consists of the amino acid sequence set forth in SEQ ID NO: 1.
US Pat. No. 10,188,704

ENHANCED MELANOMA CANCER PREVENTION BY NOVEL MELANOTROPINS

ARIZONA BOARD OF REGENTS ...

wherein Waa is a Met, Ile, or Leu, Xaa is a His or Pro, Yaa is an Arg or Leu, and Zaa is a Phe or Trp, and wherein R1 of the C-terminal is —NH2, or —OH, with the caveat that Waa is not Met, Xaa is not His, Yaa is not Arg, Zaa is not Trp, and R1 is not OH simultaneously.
US Pat. No. 10,189,217

METHOD FOR PREPARING THERMOPLASTIC PREPREG AND THERMOPLASTIC PREPREG PREPARED THEREBY

KOLON INDUSTRIES, INC., ...

1. A method for preparing a thermoplastic prepreg, comprising:laminating a thermoplastic resin film having a crystallization degree in a range of 1 to 20% on at least one surface of a matrix fiber to give a laminate; and
heating the laminate to a higher temperature than a melting point of the thermoplastic resin film, then, pressing the heated laminate,
wherein the thermoplastic prepreg has a weight variation per unit area of 3-5%,
said weight variation per unit area being determined by the following equation (I) or (II):
weight variation per unit area (%)=[(W0?W1)/W0]×100  (I)
weight variation per unit area (%)=[(W1?W0)/W0]×100  (II)
wherein W0 is an average weight of 10 samples of the thermoplastic prepreg, and
W1 is a weight of the samples which show the greatest difference from the average weight W0.
US Pat. No. 10,189,993

SILOXANE COMPOSITION AND METHOD FOR PRODUCING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A method of preparing a siloxane composition, comprising:a step of producing a crosslinked organopolysiloxane having a weight-average molecular weight of 5,000 to 300,000,000 and containing 0.1 to 50 moles of silethylene linkages per 1,000 moles of siloxane units by hydrosilylation of an organopolysiloxane having a structure of formula (1) below with an organohydrogenpolysiloxane having a structure of formula (2) below
M?MVi?D?DVi?T?TVi?Q?  (1)
M?MH?D?DH?T?TH?  (2)(wherein M is R3SiO1/2, MVi is R2PSiO1/2, D is R2SiO2/2, DVi is RPSiO2/2, T is RSiO3/2, TVi is PSiO3/2, MH is R2HSiO1/2, DH is RHSiO2/2, TH is HSiO3/2 and Q is SiO4/2, each R being independently an unsubstituted or substituted monovalent hydrocarbon group of 1 to 12 carbon atoms that has no aliphatic unsaturated bonds and P being an alkenyl group represented by —(CH2)a—CH?CH2 (where “a” is 0 or an integer from 1 to 6); and ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ? and ? are each independently 0 or a positive number, with the provisos that ?, ? and ? are not all 0, ?+?+??2, ?, ? and ? are not all 0, and ?+?+??2) in an amount of solvent that is at least 8 times the combined weight of the polysiloxanes of formulas (1) and (2) and using a platinum group metal compound, andafter obtaining the crosslinked organopolysiloxane using an organic solvent selected from among toluene, hexane, xylene and methyl ethyl ketone as the solvent: adding a low-viscosity organopolysiloxane as a solvent, and distilling off the organic solvent by heating under reduced pressure so as to give a composition that contains no organic solvent.
US Pat. No. 10,189,995

ASPHALT COMPOSITION

Asahi Kasei Kabushiki Kai...

1. An asphalt composition, comprising0.5 parts by mass or more and 20 parts by mass or less of a block copolymer, and
100 parts by mass of an asphalt;
wherein the block copolymer comprises a polymer block (A) mainly comprising a vinyl aromatic monomer unit, and a copolymer block (B) comprising a conjugated diene monomer unit and a vinyl aromatic monomer unit; the content of the vinyl aromatic monomer unit in the block copolymer being 20% by mass or more and 60% by mass or less;
wherein a content of the polymer block (A) in the block copolymer is 10% by mass or more and 40% by mass or less;
wherein a hydrogenation rate of a double bond in the conjugated diene monomer unit of the block copolymer is 40% or more and 100% or less;
wherein the asphalt has a colloidal index ((a saturate fraction content+an asphaltene fraction content)/(a resin fraction content+an aromatic fraction content)) of 0.30 or more and 0.54 or less, and a saturate fraction content of 11% by mass or less,
wherein the conjugated diene monomer unit of the block copolymer comprises a conjugated diene monomer unit (a) derived from a 1,2-bond and/or a 3,4-bond and a conjugated diene monomer unit (b) derived from a 1,4-bond, and
wherein a total content of the conjugated diene monomer units is 100% by mass,
wherein a content of an alkenyl monomer unit (a1) in the conjugated diene monomer unit (a) hydrogenated is 10% by mass or more and 50% by mass or less,
wherein a content of an alkenyl monomer unit (b1) in the conjugated diene monomer unit (b) hydrogenated is 0% by mass or more and 80% by mass or less, and
wherein a sum of contents of a non-hydrogenated conjugated diene monomer unit (a2) after hydrogenation and a non-hydrogenated conjugated diene monomer unit (b2) after hydrogenation is 0% by mass or more and 90% by mass or less.
US Pat. No. 10,188,716

PROTECTIVE ANTIGEN COMPLEXES WITH INCREASED STABILITY AND USES THEREOF

Wichita State University,...

1. A method for inducing an immunogenic response in a subject against B. anthracis, said method comprising administering to the subject a therapeutically-effective amount of an immunogenic composition against Bacillus anthracis, said composition comprising a stabilized protective antigen complex, said complex comprising Bacillus anthracis protective antigen protein and capillary morphogenesis protein-2, wherein said capillary morphogenesis protein-2 is bound to said protective antigen protein along a binding interface.
US Pat. No. 10,190,002

AQUEOUS MULTI-STAGE EMULSION COPOLYMER COMPOSITIONS FOR USE IN JOINERY APPLICATIONS

Rohm and Haas Company, P...

1. An aqueous composition comprising aqueous multistage emulsion copolymer compositions comprising (a) one or more dihydrazide compounds in a total amount of from 0.5 to 4 wt. %, based on the total weight of composition solids, and (b) of one or more aqueous multistage emulsion copolymers containing, as (i) a first stage, an emulsion copolymer having a glass transition temperature (Tg) via differential scanning calorimetry (DSC) of from ?50 to 30° C., and containing, in copolymerized form, from 0.5 to 3.0 wt. % of one or more monoethylenically unsaturated phosphorous acid monomers and, from 0.75 to 5 wt. % of one or more keto group containing amide monomers, and, as (ii) a second stage, an emulsion copolymer having a DSC Tg of from 50° C. to 125° C., wherein the Tg difference between the first stage and the second stage is from 45° C. to 150° C. having a weight ratio of (i) the first stage to (ii) the second stage, based on copolymer solids, ranging from 50:50 to 90:10 or, all monomer wt. % s based on the total weight of monomers used to make the aqueous multistage emulsion copolymer, and, further wherein, the (ii) second stage of the aqueous multistage emulsion copolymer comprises, in copolymerized form, no more than 25 wt. % of the total monoethylenically unsaturated phosphorous acid monomers used to make the aqueous multistage emulsion copolymer, and no more than 50 wt. % of the total keto group containing amide monomers used to make the aqueous multistage emulsion copolymer, and wherein (b) at least one of the one or more aqueous multistage emulsion copolymer comprises, in copolymerized form, at least 90 wt. % of the one or more monoethylenically unsaturated phosphorous acid monomers in the (i) first stage.
US Pat. No. 10,188,723

FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS)

NOVAVAX, INC., Gaithersb...

1. A vaccine comprising an influenza VLP, wherein said VLP comprises influenza proteins, wherein the influenza proteins consist of M1, HA and NA proteins; wherein the M1 protein is derived from a different influenza virus strain than the HA and NA proteins; wherein the influenza proteins are insect-cell expressed, and wherein the M1 protein is from an avian influenza strain.
US Pat. No. 10,191,032

METHOD OF DETECTION AND TREATMENT OF CLINICALLY SIGNIFICANT POST-PRANDIAL HYPERGLYCEMIA IN NORMOGLYCEMIC PATIENTS

True Health IP LLC, Fris...

1. A method of treating post-prandial hyperglycemia in a patient having impaired first-phase insulin response comprising:a. measuring a level of alpha-hydroxybutyrate (AHB) in a single fasting baseline biological sample of the patient;
b. comparing the level of AHB in the single fasting baseline biological sample to a reference AHB level; and
c administering to the patient a diabetes therapy if the level of AHB in the single fasting baseline biological sample is determined to be at least 6.0 ?g/mL.
US Pat. No. 10,188,984

PROCESS FOR REMOVING OXIDISABLE GASEOUS COMPOUNDS FROM A GAS MIXTURE BY MEANS OF A PLATINUM-CONTAINING OXIDATION CATALYST

1. A process for catalytic oxidative removal of at least one oxidisable gaseous compound from a gas mixture, the gas mixture comprising the at least one oxidisable gaseous compound as well as oxygen, the process comprising:reacting H2Pt(OH)6 with oxalic acid in an aqueous solution to form platinum oxalate complexes of the formula (H3O)1.6[Pt(C2O4)2]. 2H2O;
forming an oxidation catalyst by adding the platinum oxalate complexes to a porous catalyst support and exothermically decomposing the platinum oxalate complexes to generate catalytically active platinum species; and
oxidizing the gas mixture with the oxidation catalyst, wherein
the gas mixture is not a combustion flue gas.
US Pat. No. 10,188,729

MODULATION OF TUMOR IMMUNITY

1. A method of treating a tumor in a patient comprising administering to the patient a bispecific antibody comprising(i) a first arm having a light chain (LC) variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence of the LC variable region of MK-3475 and a heavy chain (HC) variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence of the HC variable region of MK-3475; and
(ii) a second arm having an LC variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence set forth in SEQ ID NO: 82 wherein residue 31 is Q and residue 57 is Q; and an HC variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence set forth in SEQ ID NO: 81.
US Pat. No. 10,193,094

ORGANIC LIGHT-EMITTING DEVICE HAVING DELAYED FLUORESCENCE

Merck Patent GmbH, (DE)

1. An organic electroluminescent device comprisinganode,
cathode,
at least one emitting layer which comprises a luminescent organic compound E which has a difference between the energies of its S1 and T1 states of not greater than 0.15 eV, and
2, 3, 4 or 5 layers H each having a thickness of greater than 2 nm which are arranged between one emitting layer of said at least one emitting layer, which is closest to said anode, and said anode,
where the following conditions apply to each layer H:
a difference D between the HOMO energy level of a layer H and the HOMO energy level of the closest layer having a thickness of greater than 2 nm on a cathode side of this layer H must be less than or equal to 0.4 eV, and
each of the layers H comprises at least one triarylamino compound which is a small organic molecule,
with the proviso that, for layers whose HOMO energy level has a value of less than ?6.7 eV, the LUMO energy level for the said condition occurs instead of the HOMO energy level and wherein the emitting layer which comprises compound E additionally comprises one or more matrix materials, and in that compound E is an emitting compound and the energy of the T1 state of the matrix material of the emitting layer is at most 0.1 eV lower than the energy of the T1 state of compound E.
US Pat. No. 10,190,020

SILOXANE-BASED COATINGS CONTAINING POLYMERS WITH UREA LINKAGES AND TERMINAL ALKOXYSILANES

The United States of Amer...

8. A composition comprising:an amine-functional compound or an epoxy- or acrylate-functional compound; and
a urea-containing composition made by a method comprising:
reacting an amino-functional alkoxysilane with a first polyisocyanate to form one or more adducts having an unreacted isocyanate group; and
reacting the adducts with one or more polyfunctional amino- and/or hydroxyl compounds and a second polyisocyanate to form the urea-containing composition;
wherein the urea-containing composition comprises at least two residues of the polyfunctional amino- and/or hydroxyl compounds;
wherein isocyanate groups do not react with other isocyanate groups; and
wherein the urea-containing composition contains no unreacted isocyanate groups;
wherein the urea-containing composition is characterized by any of:
a) at least one of the polyfunctional amino- and/or hydroxyl compounds comprises an amino group and at least one of the polyfunctional amino- and/or hydroxyl compounds comprises a hydroxyl group;
b) at least one of the polyfunctional amino- and/or hydroxyl compounds is a polyfunctional amino compound; and
c) the urea-containing composition comprises one of more compounds having the formula:
{[(R1O)aR13-aSi—(CH2)3—NR2—CO—NH]n—R3—NH—CO—X—R5—X—CO—NH}m—R3
wherein each a is independently selected from 1, 2, or 3;
wherein m is 2 or 3;
wherein each n is independently selected from 1 or 2;
wherein each X is independently selected from —NR4— and —O—;
wherein each R1 group is an independently selected alkyl group;
wherein each R2 and R4 is independently selected from hydrogen, aryl, alkyl, cycloalkyl, ester-containing aliphatic, ester-containing fluorinated aliphatic, amide-containing aliphatic, and polysiloxane;
wherein each R3 is an independently selected residue of an aliphatic, cycloaliphatic, or aromatic polyisocyanate having 2 or 3 isocyanate groups; and
wherein each R5 independently comprises a group selected from aliphatic, cycloaliphatic, aromatic, polyester, polyether, polysulfide, polyurethane, polycarbonate, polysiloxane, and any combination thereof moisture-curing the composition.
US Pat. No. 10,193,097

LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE

Semiconductor Energy Labo...

10. A light-emitting element comprising:a first electrode;
a hole-injecting layer over the first electrode
a hole-transporting layer over the hole-injecting layer;
a light-emitting layer over the hole-transporting layer;
an electron-transporting layer over the light-emitting layer;
an electron-injecting layer over the electron-transporting layer;
a second electrode over the electron-injecting layer;
a first layer between the hole-transporting layer and the light-emitting layer; and
a second layer between the light-emitting layer and the electron-transporting layer,
wherein:
the light-emitting layer includes a first phosphorescent compound,
the first layer includes a first hole-transporting material and a first electron-transporting material,
the second layer includes a second hole-transporting material and a second electron-transporting material,
the second hole-transporting material includes a second phosphorescent compound,
in the first layer, a concentration of the first hole-transporting material is higher than that of the first electron-transporting material,
in the second layer, a concentration of the second electron-transporting material is higher than that of the second hole-transporting material, and
a difference between a wavelength of a highest peak of an emission spectrum of the second phosphorescent compound and a wavelength of a highest peak of an emission spectrum of the first phosphorescent compound is within 30 nm.
US Pat. No. 10,189,764

HYDROGENATION OF OXYGENATED MOLECULES FROM BIOMASS REFINING

VIRDIA, INC., Raceland, ...

1. A method for producing 2-butanone and a conversion product, the method comprising:dehydrogenating 2-butanol to yield 2-butanone, thereby releasing hydrogen;
using hydrogen released from the dehydrogenating in a conversion reaction, wherein the conversion reaction converts a biomass-derived molecule to a conversion product; and
recovering 2-butanone and the conversion product.
US Pat. No. 10,188,740

MODIFIED FC MOLECULES

AMGEN INC., Thousand Oak...

1. A composition of matter comprising:(i) a monomeric or multimeric Fc domain having a cysteine or non-canonical amino acid substitution at one or more specifically selected conjugation site(s) selected from D46, S48, H49, E50, E53, K55, D61, G62, Q76, Y81, K107, K121, G122, Q123, E126, R136, D137, T140, K141, N142, E169, N170, N171, K173, L179, S181, G183, D194, K195, R197, Q199, Q200, G201, N202, or S223, relative to reference sequence SEQ ID NO:599; and
(ii) at least one additional functional moiety, wherein the functional moiety is conjugated to the Fc domain through the side chain of the cysteine residue or non-canonical amino acid residue substituted at said one or more conjugation site(s).
US Pat. No. 10,190,022

ANTIFOULING COMPOSITION, ANTIFOULING SHEET, AND METHOD FOR MANUFACTURING ANTIFOULING SHEET

LINTEC CORPORATION, Itab...

1. An antifouling composition comprising a polysilazane-based compound (A) and a both terminal carboxy-modified silicone (B),wherein a content of the silicone (B) is from 0.01 to 10 parts by mass based on 100 parts by mass of a total amount of the compound (A), and the antifouling composition is suitable for use as a sheet-like antifouling layer-forming material.
US Pat. No. 10,189,766

PROCESS FOR PRODUCING 2-ETHYLHEXANAL HELPING TO IMPROVE YIELD

NAN YA PLASTICS CORPORATI...

1. A process for producing 2-ethylhexanal helping to increase yield of 2-ethylhexanal, comprises the following steps:1) placing a reaction liquid containing 60-100 wt % of 2-ethyl-2-hexenal into a single reaction tank having internally equipped with a gas-introducing mixer which comprising a hollow rotatory shaft thereof and vanes at a terminal of the hollow rotatory shaft for use in introducing and exhausting hydrogen gas to the reaction liquid and simultaneously stirring the reaction liquid if started;
2) based on the weight of 2-ethyl-2-hexenal, adding a palladium on carbon catalyst ranged from 0.02 wt % to 15 wt % for hydrogenation, whose palladium component is supported on a carbon carrier having a total content of impurities less than 8% by weight of the carbon carrier, and whose specific surface area of the impurities of the carbon carrier is ranged between 800 m2/g and 3,000 m2/g;
3) introducing hydrogen gas to 80-600 lb/in2 and holding this pressure;
4) activating the gas-introducing mixer to stir the reaction liquid at room temperature and held the pressure for 10 minutes, heating to 70-150° C., and allowing hydrogenation for 1-10 hours at this temperature; and
5) upon completion of the reaction, cooling the reaction liquid to room temperature and filtering out the catalyst to obtain a yield of the 2-ethylhexanal at least up to 98.0%.
US Pat. No. 10,191,303

MULTIFOCAL BIMODULUS CONTACT LENSES

NexisVision, Inc., Menlo...

1. An ophthalmic lens for correcting presbyopia of an eye, the eye having a cornea characterized by a refractive shape extending across an optical region of the cornea, the ophthalmic lens comprising:an inner optic portion and a peripheral portion disposed radially outward of the inner optic portion, wherein,
the inner optic portion is configured to be disposed over the optical region of the cornea;
the inner optic portion is characterized by an inner rigidity and the peripheral portion is characterized by a peripheral rigidity;
the inner rigidity is greater than the peripheral rigidity; and
the inner rigidity is from about 1E8 MPa-?m3 to about 1E11 MPa-?m3; and
an anterior surface and a posterior surface opposite the anterior surface, wherein,
a portion of the anterior surface is configured to correct presbyopia; and
the posterior surface is configured to provide one or more lenticular volumes between the posterior surface and the optical region of the cornea.
US Pat. No. 10,188,742

BI-SPECIFIC ANTIBODIES AND USES THEREOF

KAOHSIUNG MEDICAL UNIVERS...

1. A humanized bi-specific antibody against the terminal methoxy or hydroxyl group of polyethylene glycol (PEG) and a target ligand, comprising,a first antigen binding site that binds to the PEG; and
a second antigen binding site that binds to the target ligand that is HER2;
wherein,
the first antigen binding site comprises the first VL-Ck domain consisting of SEQ ID NO: 12, the first VH-CH1 domain consisting of SEQ ID NO: 13, and the first HR-CH2-CH3 domain consisting of SEQ ID NO: 22; and
the second antigen binding site comprises a humanized single chain variable fragment (scFv) consisting of SEQ ID NO: 15.
US Pat. No. 10,189,767

PROCESS FOR MANUFACTURING SUCCINIC ACID FROM A FERMENTATION BROTH USING NANO FILTRATION TO PURIFY RECYCLED MOTHER LIQUOR

DSM IP ASSETS B.V., Heer...

1. A process for manufacturing succinic acid comprising:a) providing an aqueous solution of succinic acid;
b) crystallizing the succinic acid from the aqueous solution to form intermediate crystals and a mother liquor;
c) separating the intermediate crystals from the mother liquor;
d) treating the mother liquor by nanofiltration;
e) recycling the treated mother liquor to b);
f) purifying the intermediate crystals; and
g) recovering succinic acid.
US Pat. No. 10,190,024

POLISHING COMPOSITION

FUJIMI INCORPORATED, Kiy...

1. A polishing composition, comprising silica particles as abrasives and a basic compound as polishing removal accelerator, whereina density of silanol groups of the silica particles is 1.5 to 6.0 pieces/nm2,
an adsorption ratio parameter A of the polishing composition is 1.2 or less, the adsorption ratio parameter represents concentration dependency of an amount of adsorption of the basic compound to the silica particles as a ratio of high-concentration adsorption amount/low-concentration adsorption amount, and
the polishing composition has a pH of 8 to 12.
US Pat. No. 10,191,048

FLUOROMETRIC IMMUNOASSAY FOR DETECTION OF ANTI-DSDNA ANTIBODIES

1. A fluorometric immunoassay method for detecting antibodies against double-stranded DNA (anti-dsDNA), comprisingproviding decomplemented sera from a patient, providing isolated dsDNA as antigens from a source,
Precipitating immune complexes with a saturated solution of ammonium sulfate or solution of polyethylene glycol (PEG), wherein the immune complexes are a consequence of incubation of decomplemented patient's sera with the dsDNA,
separating the immune complexes into two samples,
labeling the samples by adding fluorescent dyes specific to the dsDNA to the samples, and
detecting of fluorescence in the samples, namely sample with supernatant and sample with precipitate, comprising immune complexes comprising dsDNA and anti-dsDNA,
wherein the detected fluorescence is a consequence of binding of fluorescent dyes into the dsDNA.
US Pat. No. 10,189,768

PROCESS FOR HYDROGENOLYSIS OF ALPHA-HYDROXY ESTERS OR ACIDS USING A HETEROGENEOUS CATALYST

Danmarks Tekniske Univers...

1. A method for hydrogenolysis of alpha-hydroxy esters or acids, comprising:reacting the alpha-hydroxy ester or acid in the presence of a solid catalyst and a catalyst support,
wherein the catalyst comprises at least two different metals that are Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, Ru, Rh, Pd, Ag, Cd, W, Re, Os, Ir, Pt, Au, or Hg, or a combination thereof, and
wherein the catalyst support is a porous solid material with the proviso that if the porous solid material consists of one metal oxide, the metal oxide is not SiO2.
US Pat. No. 10,188,744

AMPHIPATHIC PEPTIDE

1. An amphipathic cell penetrating peptide of less than 50 amino acid residues comprising at least 6 arginine residues (R), at least 12 alanine residues (A), at least 6 leucine residues (L), optionally at least one cysteine residue (C) and at least two but no greater than three glutamic acids (E) whereinthe arginine (R) residues are evenly distributed along the length of the peptide;
the ratio of arginine (R) to negatively charged glutamic acid (E) residues is from at least 6:2 to 9:2; and
the ratio of hydrophilic amino acid residues to hydrophobic amino acid residues at pH 7 is at least 30:67 to 40:60; or
wherein the peptide comprises or consists of WEARLARALARALARELARALARALRACEA (SEQ ID No. 4).
US Pat. No. 10,190,026

WOOD ADHESIVE

INDUSTRIAL TECHNOLOGY RES...

1. A wood adhesive, consisting of:a first agent, consisting of:
a sodium carboxymethyl cellulose having a molecular weight between 15,000 and 500,000 and a degree of substitution of from 0.4 and 2.00 of the sodium salt; and
a styrene-butadiene rubber polymer; and
a second agent, consisting of:
a polymeric quaternary amine and NaOH, wherein a ratio of the weight of the styrene-butadiene rubber polymer to the sum of weights of the sodium carboxymethyl cellulose and the polymeric quaternary amine is in the range from 0.05:1 to 1:0.1.
US Pat. No. 10,193,117

SEPARATOR FOR NONAQUEOUS SECONDARY BATTERY, AND NONAQUEOUS SECONDARY BATTERY

TEIJIN LIMITED, Osaka (J...

1. A separator for a nonaqueous secondary battery, comprising a porous substrate and an adhesive porous layer that is formed on at least one side of the porous substrate and contains a polyvinylidene-fluoride-based resin,the separator for a nonaqueous secondary battery being characterized in that the adhesive porous layer has a crystal size of 1 nm or more and 13 nm or less.
US Pat. No. 10,188,760

MODULATION OF IMMUNITY AND CEACAM1 ACTIVITY

1. A method for diagnosing a cancer in a human patient, said method comprising the step of contacting a biological sample derived from said patient with a CEACAM1 binding agent conjugated to a detectable moiety, wherein the CEACAM1 binding agent comprises a multimer agent consisting of at least two peptides selected from the group consisting of GYSWYK (SEQ ID NO:33), NRQII (SEQ ID NO:34), and QNDTG (SEQ ID NO: 35).
US Pat. No. 10,188,773

COMPOSITIONS AND DEVICES OF POLY-4-HYDROXYBUTYRATE

Tepha, Inc., Lexington, ...

1. A composition comprising a polyhydroxyalkanoate (PHA) polymer obtained by a process comprising: suspending a PHA polymer biomass in ethanol for a period of time effective to extract lipids into the ethanol, separating the PHA polymer biomass from the ethanol by solid-liquid separation, collecting the ethanol-washed biomass, and extracting the PHA polymer into a solvent.
US Pat. No. 10,193,132

SYNTHESIS OF SUBMICROMETER TO MICROMETER-SIZED CATHODE MATERIALS

Washington University, S...

1. A method of producing submicrometer- to micrometer-sized, spherical-shaped cathode materials for lithium ion batteries, the method comprising:dissolving a lithium salt and a metal salt in water, alcohol, oil or a mixture of any two or more thereof, forming a lithium metal precursor solution,
spraying the precursor solution to form fine aerosolized droplets,
flowing the aerosolized droplets in a carrier medium into a pyrolysis hydrogen flame producing submicrometer- to micrometer-sized spherical lithium-metal-oxide particles in a range of from about 0.1 ?m to about 100 ?m, wherein no external heat source is required, and wherein the droplets are flowing in an environment having a temperature of less than 1200° C., wherein the submicrometer- to micrometer-sized spherical-shaped lithium-metal-oxide particles produced have a formula of Li?M??O? wherein ? is 0???1; ? is 0???2; and ? is 0???4; and wherein M? is selected from the group consisting of Ni, Co, Mn, Al, Mg, Fe, Cu, Zn, V, Mo, Nb, Cr, Si, Ti, Zr, and a mixture of any two or more thereof.
US Pat. No. 10,188,774

METHOD FOR PRODUCING ANTITHROMBOTIC COATING MATERIAL

TERUMO KABUSHIKI KAISHA, ...

1. A method for producing an antithrombotic coating material, the method comprising:preparing a methanol solution containing a monomer consisting of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof;
adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid, wherein the radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less is 2,2?-azobis(4-methoxy-2,4-dimethylvaleronitrile); and
polymerizing the monomer to form a polymer, wherein the monomer used to form the polymer consists of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof.
US Pat. No. 10,193,134

DOPED SODIUM MANGANESE OXIDE CATHODE MATERIAL FOR SODIUM ION BATTERIES

UMICORE, Brussels (BE) U...

1. A sodium transition metal cathode material for a rechargeable sodium battery, having a P2 layered bronze crystal structure and having a composition NaxMO2, M comprising at least 55 mol % manganese, wherein the manganese valence state is at least 3.75, wherein 2/3
US Pat. No. 10,193,138

GLASS-FIBER CONTAINING COMPOSITE MATERIALS FOR ALKALI METAL-BASED BATTERIES AND METHODS OF MAKING

Johns Manville, Denver, ...

1. A method of making a glass-fiber composite, the method comprising the steps of:forming a wet laid non-woven glass fiber substrate, wherein the glass fiber substrate comprises a sodium-based compound selected from the group consisting of NaMnO2; NaNiO2; Na(Ni0.5Mn0.5)O2, NaFePO4, Na2Fe2(SO4)3, and Na2Mn11[Mn11(CN)6]; and contacting alkali-metal containing particles on the substrate.
US Pat. No. 10,189,808

SOLID FORMS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES

Celgene Corporation, Sum...

1. A solid form of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a tautomer thereof, which is Form C having an X-ray powder diffraction pattern comprising peaks at about 16.7, 16.9, 17.7 or 24.7 degrees 2?.
US Pat. No. 10,193,143

NEGATIVE ELECTRODE ACTIVE MATERIAL FOR ELECTRICITY STORAGE DEVICES AND METHOD FOR PRODUCING SAME

NIPPON ELECTRIC GLASS CO....

1. A negative electrode active material for an electricity storage device, comprising a composition containing TiO2, Na2O, and a network-forming oxide, and comprising a precipitated crystal of a monoclinic crystal containing Na, Ti, and O.
US Pat. No. 10,190,072

METHOD FOR IMPROVING ENGINE FUEL EFFICIENCY

EXXONMOBIL RESEARCH AND E...

1. A method for improving fuel efficiency and reducing frictional properties, while maintaining or improving deposit control, in an engine lubricated with a lubricating oil by using as the lubricating engine oil a formulated oil, said formulated oil having a composition comprising:from 75 to 95 wt % of lubricating oil base stock selected from the group consisting of a Group I base stock, a Group II base stock, a Group III base stock, a Group IV base stock, a Group V base stock and combinations thereof;
a friction modifier mixture comprising a polymeric ethoxylated fatty acid ester having a molecular weight of greater than or equal to 2000 at from 0.1 to 1.0 wt. % of the weight of the lubricating engine oil and an organic molybdenum containing friction modifier contributing from 80 ppm to 500 ppm of elemental molybdenum based on the weight of the lubricating engine oil, and
an overbased calcium salicylate detergent contributing from 200 ppm to 2000 ppm of elemental calcium based on the weight of the lubricating engine oil;
wherein the remainder of the lubricating engine oil includes one or more other lubricating oil additives;
wherein fuel efficiency and friction reduction properties are improved (mini-traction machine (MTM) in Stribeck mode friction coefficient at 140° C. less than or equal to 0.20) and deposit control is maintained or improved (TEOST 33C total deposits less than or equal to 30 mg) as compared to friction reduction properties and deposit control achieved using the same lubricating engine oil not containing the friction modifier mixture and the overbased calcium salicylate detergent.
US Pat. No. 10,189,818

5-(5-(2-(3-AMINOPROPDOXY)-6-METHOXYPHENYL)-1H-PYRAZOL-3-YLAMINO)PYRAZINE-2-CARBONITFILE (S)-LACTATE MONOHYDRATE

Eli Lilly and Company, I...

1. A compound which is 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile (S)-lactate monohydrate.
US Pat. No. 10,193,171

FUEL CELL WITH INTEGRATED WATER MANAGEMENT LAYER AND FABRICATION METHOD THEREOF

1. Fabrication method of a fuel cell comprising the following successive steps:providing a substrate comprising:
at least one membrane-electrode assembly, formed by an electrolytic membrane arranged between a first electrode and a second electrode,
a first current collector arranged on the first electrode,
depositing a fluoropolymer solution on the first current collector,
making a solvent of the fluoropolymer solution evaporate so as to form a porous thin layer of fluoropolymer.
US Pat. No. 10,190,097

METHOD AND COMPOSITION FOR INDUCING HUMAN PLURIPOTENT STEM CELLS

The Regents of the Univer...

1. A method of pluripotency reprogramming, comprising:treating a human cell with a cell culture medium comprising fibromodulin (FMOD) for a period ranging from a day to a month, and
changing the cell culture medium regularly until a FMOD reprogrammed (FreP) cell forms;
wherein the FreP cell expresses NANOG and does not form teratoma, and
wherein the human cell is a fibroblastic cell.
US Pat. No. 10,193,183

NONAQUEOUS ELECTROLYTE SECONDARY BATTERIES

SANYO Electric Co., Ltd.,...

1. A nonaqueous electrolyte secondary battery comprising a positive electrode including a lithium transition metal oxide, a negative electrode including a negative electrode active material capable of storing and releasing lithium ions, and a nonaqueous electrolyte,the negative electrode active material including a carbon material as a main component,
the negative electrode including a lithium tungsten composite oxide and/or a lithium molybdenum composite oxide.
US Pat. No. 10,188,056

HYBRID TOMATO VARIETY 72-762 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum tomato plant designated 72-762 RZ, representative seed of which having been deposited under NCIMB Accession No. 42810.
US Pat. No. 10,190,108

METHOD FOR REDUCING VISCOSITY IN SACCHARIFICATION PROCESS

DANISCO US INC., Palo Al...

1. A biomass saccharification mixture comprising:a. a pretreated biomass material; and
b. a non-naturally occurring enzyme composition comprising a glycosyl hydrolase family 61 (“GH61”) polypeptide having GH61/endoglucanase activity, wherein the GH61 polypeptide
i) has at least 65% in sequence identity to residues 22-344 of SEQ ID NO:27; or
ii) is encoded by a polynucleotide sequence or a complement thereof that has at least 65% sequence identity to SEQ ID NO:30; or
iii) is encoded by a polynucleotide sequence that hybridizes under high stringency conditions to a sequence that is complementary to SEQ ID NO:30;
wherein the enzyme composition is a whole cellulase comprising at least one polypeptide having cellobiohydrolase activity, at least one polypeptide having endoglucanase activity that is different from the GH61 polypeptide, and at least one polypeptide having beta-glucosidase activity and wherein the whole cellulase is derived from a host cell containing a heterologous expression cassette comprising a nucleic acid encoding the GH61 polypeptide, wherein the GH61 polypeptide is present in the whole cellulase in an amount of at least 6 wt % and no more than 50 wt % based on the total weight of protein in the whole cellulase and wherein said biomass saccharification mixture has a lower viscosity than a biomass saccharification mixture without the GH61 polypeptide and/or is capable of increasing the level of saccharification in the mixture as compared to the level of saccharification in a mixture having no or a lower level of GH-61 polypeptide.
US Pat. No. 10,188,060

SOYBEAN CULTIVAR S170005

M.S. Technologies, LLC, ...

1. A plant of soybean cultivar S170005, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-124455.
US Pat. No. 10,193,188

AQUEOUS ELECTROLYTE WITH ETHERS AND BATTERIES USING THE ELECTROLYTE

5. A lithium ion battery comprising:an anode capable of intercalation and de-intercalation of lithium ions;
a cathode comprising an active material selected from the group consisting of LiMn2O4, LiCoO2, LiFe(PO4), LiMn1/3Ni1/3Co1/3O2, LiNi0.5Mn1.5O4 and LiCoPO4; and
an aqueous electrolyte in contact with the anode and cathode which comprises:
water;
at least one of a linear ether and a cyclic ether; and
a lithium salt of an anion comprising a fluoroalkylsulfonyl group of formula (I):
R—SO2-  (I)
wherein R is a perfluoroalkyl group of 1-5 carbons, and
wherein relative mole ratios of ether (Y) and water (Z) to Li-salt of formula satisfy the following formulas:
Y/X is from 1/10 to 50/1; and
Z/X is from 1/10 to 5/1.
US Pat. No. 10,190,115

METHODS AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS

Bio-Rad Laboratories, Inc...

1. A composition comprising a plurality of second partitions containing first partitions, wherein:a. said first partitions are degradable upon the application of a stimulus to said first partitions such that contents of a first partition is mixed with contents of a second partition; and
b. said first partitions are contained within the second partitions;
c. said first partitions contain an oligonucleotide barcode; and
d. the first partitions have on average a first average volume and the second partitions have on average a second average volume, wherein the second average volume is at least twice as large as the first average volume.
US Pat. No. 10,188,589

DEPOSITION OF HYDROPHOBIC ACTIVES IN THE PRESENCE OF SURFACTANTS

Dow Global Technologies L...

1. A personal care composition, comprising:an anionic surfactant; and
a polyurea shell encapsulating a hydrophobic personal care active selected from the group consisting of a fragrance, a vitamin, an extract, or a therapeutic active, wherein the polyurea shell has at least one covalently attached cationic polymer, selected from the group consisting of quaternary amines and cationic biopolymers, wherein the polyurea shell has at least one covalently attached quaternary amine that is the reaction product of (2-Aminoethyl) trimethylammonium chloride and polyisocyanate.
US Pat. No. 10,188,082

METHODS FOR INCREASING GENETIC PROGRESS IN A LINE OR BREED OF SWINE USING SEX-SELECTED SPERM CELLS

Inguran, LLC, Navasota, ...

1. A method of producing an embryo or zygote in a genetic nucleus comprising the steps of:collecting a semen sample from a boar from the genetic nucleus;
sorting the semen sample into at least two subpopulations of sperm cells, wherein at least 60% of a first subpopulation bears X-chromosomes or Y-chromosomes;
fertilizing an egg from a sow from the genetic nucleus with one or more sperm cells from the first subpopulation to produce a zygote or embryo;
genotyping the zygote or embryo to obtain a genotype;
determining an estimated breeding value for the zygote or embryo; and
selecting the zygote or embryo to develop into offspring that is used for breeding in the genetic nucleus based on the estimated breeding value.
US Pat. No. 10,189,879

DNA-BINDING PROTEIN USING PPR MOTIF, AND USE THEREOF

HIROSHIMA UNIVERSITY, Hi...

1. A pentatricopeptide repeat (PPR) fusion protein comprising:9 PPR motifs belonging to the p63 protein consisting of the amino acid sequence of SEQ ID NO: 1,
11 PPR motifs belonging to the GUN1 protein consisting of the amino acid sequence of SEQ ID NO: 2,
15 PPR motifs belonging to the pTac2 protein consisting of the amino acid sequence of SEC) ID NO: 3,
10 PPR motifs belonging to the DG1 protein consisting of the amino acid sequence of SEQ ID NO: 4, or
11 PPR motifs belonging to the GRP23 protein consisting of the amino acid sequence of SEQ ID NO: 5; and
a nuclear transfer signal inserted at an N-terminus of the PPR protein, wherein the nuclear transfer signal is encoded by a polynucleotide consisting of positions 165-185 of any one of SEQ ID NOs: 7-9.
US Pat. No. 10,190,136

MOUSE MODEL OF ALPHA-ONE ANTITRYPSIN (AAT) DEFICIENCY

University of Massachuset...

1. A transgenic mouse whose genome comprises inactivating mutations in exon 2 of each of Serpina1a, Serpina1b, Serpina1c, Serpina1d, and Serpina1e genes, and which expresses no hepatic or circulatory Alpha-One Antitrypsin (AAT) protein.
US Pat. No. 10,190,649

FRICTION MATERIAL

AKEBONO BRAKE INDUSTRY CO...

1. A friction material comprising:a fiber base material;
a friction modifier; and
a binder,
wherein a content of copper is 0.5% by mass or less in terms of copper element,
wherein a content of the binder is 10% by mass or more,
wherein the friction material contains calcium hydroxide and zinc,
wherein the friction material has pH of 113 or more,
wherein a content of the zinc is from 1% by mass to 5% by mass,
wherein the zinc comprises a powder having an average particle diameter in a range of 1 ?m to 10 ?m,
wherein the calcium hydroxide comprises powder having an average particle diameter in a range of 5 ?m to 50 ?m,
wherein the fiber base material comprises a bio-soluble inorganic fiber, and
wherein the binder consists of at least one selected from the group consisting of an acrylic rubber-modified phenol resin, a silicone rubber-modified phenol resin, an NBR rubber-modified phenol resin, a cashew-modified phenol resin, an epoxy-modified phenol resin and an alkylbenzene-modified phenol resin.
US Pat. No. 10,190,140

INCREASED PRODUCTION OF TERPENES AND TERPENOIDS

EVOLVA SA, Reinach (CH)

1. A method for producing a terpene or a terpenoid in a recombinant host cell, comprising culturing the recombinant host cell under conditions wherein the terpene or terpenoid is produced in the recombinant host cell, wherein the recombinant host cell is genetically engineered to produce reduced expression of an endogenous farnesyl diphosphate (FPP) synthase, an endogenous geranyl diphosphate (GPP) synthase or an endogenous enzyme having both FPP synthase and GPP synthase activity compared to a non-engineered host cell;wherein reduced expression is produced in the recombinant host cell by:
(a) introducing into the recombinant host cell a heterologous genetic construct encoding the endogenous FPP synthase, the endogenous GPP synthase, or the endogenous enzyme having both FPP synthase and GPP synthase activity operably linked to an exogenous weak promoter, wherein the weak promoter is KEX2, PGK-1, GPD1, ADH1, ADH2, PYK1, TPi1, PDC1, TEF1, TEF2, FBA1, GAL1-10, CUP1, MET2, MET14, MET25, CYC1, GAL1-S, GAL1-L, TEF1, CAG, CMV, human UbiC, RSV, EF-1alpha, SV40, Mt1, Tet-On, Tet-Off, Mo-MLV-LTR, Mx1, progesterone, RU486 or Rapamycin-inducible promoter;
(b) introducing into the recombinant host cell a heterologous genetic construct encoding the endogenous FPP synthase, the endogenous GPP synthase, or the endogenous enzyme having both FPP synthase and GPP synthase activity operably linked to a messenger RNA destabilizing motif, comprising a M1 motif of SEQ ID NO:28 and/or a M24 motif of SEQ ID NO:29; or
(c) introducing into the recombinant host cell a recombinant genetic construct, the construct comprising a gene encoding the endogenous FPP synthase, the endogenous GPP synthase, or the endogenous enzyme having both FPP synthase and GPP synthase activity operably linked to an endogenous promoter, wherein between the endogenous promoter and the gene encoding the endogenous FPP synthase, the endogenous GPP synthase, or the endogenous enzyme having both FPP synthase and GPP synthase activity is a heterologous insert sequence having the formula:
-X1-X2-X3-X4-X5-;
wherein X2 comprises at least 4 consecutive nucleotides being complementary to, and forming a hairpin secondary structure element with at least 4 consecutive nucleotides of X4;
wherein X3 either comprises zero nucleotides or one or more unpaired nucleotides forming a hairpin loop between X2 and X4;
wherein X4 comprises at least 4 consecutive nucleotides being complementary to, and forming a hairpin secondary structure element with at least 4 consecutive nucleotides of X2; and
wherein X1 and X5 comprise zero, one or more nucleotides
wherein the recombinant host cell further comprises one or more recombinant expression constructs encoding heterologous enzymes for producing said terpene or terpenoid; and
wherein the recombinant host cell further comprises a recombinant expression construct encoding a truncated version of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGR), comprising the catalytically active carboxyl terminal portion thereof, comprising a region from amino acid 619 to amino acid 1025 of SEQ ID NO:8 and having at least 90% sequence identity to the amino acid sequence set forth in SEQ ID NO:8.
US Pat. No. 10,188,605

NANOPARTICLES AND NANOPARTICLE COMPOSITIONS

Iowa State University Res...

1. An organic particle comprising a plurality of non-polymeric crosslinked amphiphiles;wherein the non-polymeric crosslinked amphiphile comprises one or more nonpolar (C6-C60)alkyl or (C6-C50)fluoroalkyl chains and one or more polar head groups;
the nonpolar chains are located on the exterior of the particle and the polar head groups are oriented toward the interior of the particle; and
the amphiphiles are covalently crosslinked to each other near the head groups through thioether groups comprising an ammonium group bonded thereto.
US Pat. No. 10,189,891

AFFINITY CHROMATOGRAPHY MATRIX

1. An immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z,wherein in at least one of the one or more mutated monomers the amino acid sequence of the monomer is defined by SEQ ID NO: 14, 16, 17, or 18.
US Pat. No. 10,189,895

ANTI-CGRP COMPOSITIONS AND USE THEREOF

ALDERBIO HOLDINGS LLC, L...

1. A pharmaceutical composition comprising a humanized anti-calcitonin gene related peptide (CGRP) antibody comprising a variable light (VL) chain polypeptide comprising the complementarity-determining region (CDR) polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO: 55, SEQ ID NO: 56 and SEQ ID NO: 57, and a variable heavy (VH) chain polypeptide comprising the CDR polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO: 58, SEQ ID NO: 59 and SEQ ID NO: 60, and a pharmaceutically acceptable excipient.
US Pat. No. 10,188,615

ALKOXY COMPOUNDS FOR DISEASE TREATMENT

ACUCELA INC., Seattle, W...

1. A method of modulating chromophore flux in a retinoid cycle comprising introducing into a subject a non-retinoid aromatic compound that inhibits 11-cis-retinol production with an IC50 of about 0.1 micromolar or less when assayed in vitro, the assay consisting of a homogenate of HEK293 cell clone expressing recombinant human RPE65 and LRAT as the source of visual enzyme, exogenous all-trans-retinol in the amount of about 20 ?M, recombinant human CRALBP in the amount of about 80 ?g/mL, about 10 mM pH 7.2 phosphate buffer, about 0.5% BSA and about 1 mM NaPPi, and wherein the amount of assay reaction product 11-cis-retinol being determined by HPLC analysis following heptane extraction of the assay reaction mixture and wherein the non-retinoid aromatic compound consists of a benzene core that is substituted with a first substituent, a second substituent, and an optional third substituent, wherein the first and second substituents are attached to the benzene core in a meta-substitution configuration, wherein the first substituent is a group selected from —CH(OH)CH(R)CH2NH2 wherein R is H, CH3, or —OH and the second substituent is an optionally substituted alkoxy group, and wherein the optional third substituent is a halogen or —OH.
US Pat. No. 10,190,153

METHODS FOR PREPARATION OF NUCLEIC ACID-CONTAINING SAMPLES USING CLAY MINERALS AND ALKALINE SOLUTIONS

MICRONICS, INC., Redmond...

1. A method for treating a nucleic acid-containing sample for analysis of nucleic acids, the method comprising the steps of:a) contacting the sample with a clay mineral, wherein the clay mineral comprises a kaolinite, a smectite or a synthetic clay mineral and the sample is selected from the group consisting of blood, plasma and serum;
b) mixing the sample and the clay mineral until the clay mineral is evenly dispersed in the sample;
c) substantially removing the clay mineral from the sample;
d) contacting the sample with an alkaline solution at a pH suitable for lysis of cell and viral particles to form a nucleic acid solution; and
e) optionally, contacting the nucleic acid solution with an acidic solution suitable for neutralizing the pH of the nucleic acid solution.
US Pat. No. 10,188,616

TOPICAL SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST FORMULATIONS AND METHODS OF USING THE SAME

Teikoku Pharma USA, Inc.,...

1. A transdermal composition comprising:a sphingosine-1-phosphate receptor agonist active agent; and
a transdermal delivery vehicle comprising an adhesive matrix comprising a polyurethane, a styrenic block copolymer, a silicone and combinations thereof.
US Pat. No. 10,190,154

REDUCED GRAPHENE OXIDE-BASED BIOSENSORS

McMaster University, Ham...

1. A biosensor comprising:a) reduced graphene oxide (rGO); and
b) a nucleic acid probe absorbed on the rGO, the nucleic acid probe comprising an RCA primer sequence linked to a recognition moiety for an analyte.
US Pat. No. 10,188,617

MODULATION OF CELLULAR DNA REPAIR ACTIVITY TO INTERCEPT MALIGNANCY

The Board of Trustees of ...

1. A method of reducing the risk of cancer in a subject having a mutation in BRCA1, comprising administering to said subject an effective amount of a DNA repair agent which is benserazide.
US Pat. No. 10,188,628

RELEASE COMPOSITION FOR DERIVATIVES OF CANNABACEAE

1. A release composition for Cannabaceae derivatives comprising a lotion made by the process of combining:A) an aqueous phase comprising an aqueous solution or suspension containing and at least one humectant; wherein the at least one humectant is present in the aqueous phase in the range of from about 0.1 to 99 wt. %, and
B) an oil phase comprising at least one surfactant and the Cannabaceae derivatives, and optionally at least one additional oil, wherein the at least one surfactant is present in the oil phase in the range of from about 1 to 99 wt. %;
wherein the Cannabaceae derivative comprises a compound selected from the group consisting of tetrahydrocannabinol, cannabidiol, cannabichromene, cannabinol, cabbabigerol, tetrahydrocannabivarin, cannabidivarin, tetrahydrocannabinol acid, cannabidiol acid, cannabigerol acid, cannabigerovarin, cannabinovarin, and tetrahydrocannabivarin acid and combinations thereof;
wherein the aqueous phase is added to the oil phase in a weight ratio of about 3:1 to 49:1;
wherein the aqueous phase is added to oil phase using low to medium shear mixing to provide the lotion; and
wherein the lotion is hydrophobic and has release properties.
US Pat. No. 10,188,631

TOPICAL LIQUID COMPOSITION COMPRISING MELATONIN

ARES TRADING S.A., Aubon...

1. A topical liquid composition for intrauterine washing, the composition comprising:a. 2-200 ng/ml melatonin (N-acetyl-5-methoxytryptamine) or an analog thereof, or a pharmaceutically acceptable salt or solvate thereof;
b. 0.01-100 mM phosphate buffer system;
c. 1×10?6-5 mg/ml methionine or cysteine;
d. 0.0008-8 mg/ml arginine;
e. 1-100 mg/ml sodium chloride;
f. a surfactant selected from 0.001-10 mg/ml polysorbate 20 and 0.1-100 mg/ml propylene glycol; and
g. water,wherein the pH of the composition is pH 7-8.5, and the composition has an osmolality of 250-350 mOsm/kg.
US Pat. No. 10,190,104

ISOFORM OF ANAPLASTIC LYMPHOMA KINASE AND ITS USES

Memorial Sloan Kettering ...

1. An isolated complementary DNA (cDNA) molecule comprising the nucleic acid sequence of exons 20-29 and a portion of intron 19 of an Anaplastic Lymphoma Kinase (ALK) gene, wherein the cDNA molecule does not comprise the nucleic acid sequence of exons 1-19 of the ALK gene, either individually or in any combination and wherein the portion of intron 19 of the ALK gene is about 400 bp in length located upstream of exon 20 of the ALK gene.