US Pat. No. 10,765,864

RETINAL-INSPIRED METHOD AND SYSTEM FOR IMPROVED DETECTION

1. A sensor data preprocessing device, comprising:a first layer of detectors configured to receive signals from an array of sensor pixels and determine changes in pixel values;
a second layer of detectors configured to receive the changes in pixel values from the first layer, detect motion based on the changes in pixel values and transmit motion value output signals to a processing station;
a third layer of detectors configured to receive the changes in pixel values from the first layer and detect global motion of objects represented by correlated changes in pixel values across a predetermined field of view, wherein the third layer is configured to produce a first suppressive signal that is applied to the motion value output signals of the second layer of detectors only if a sum of correlated changes in pixel values within the predetermined field of view exceeds a predetermined threshold; and
a fourth layer of detectors configured to receive motion output signals from the second layer and detect large environmental objects by integrating motion values within defined subsections of the predetermined field of view, wherein the fourth layer is configured to produce a second suppressive signal that is applied to the motion value output signals of detectors in the second layer for a subsection only if a sum of motion values within that subsection exceeds a predetermined threshold.

US Pat. No. 10,765,863

SYSTEMS AND METHODS FOR USING A TRANSCUTANEOUS ELECTRICAL STIMULATION DEVICE TO DELIVER TITRATED THERAPY

Elira, Inc., St. Louis, ...

1. A method of enabling a patient to achieve a weight loss objective using an electrical dermal patch secured to the patient's skin comprising a housing, an electrical pulse generator positioned within the housing, and at least one electrode attached to said housing and in electrical communication with the electrical pulse generator, wherein said electrical pulse generator is configured to deliver electrical pulses having a pulse amplitude in a range of 1 mA to 65 mA, the method comprising:using a plurality of programmatic instructions configured to execute on a device external to the electrical dermal patch, receiving data indicative of at least one of weight, well-being, hunger, appetite, calories consumed by the patient, or calories expended by the patient;
applying a plurality of stimulation sessions to the patient's skin using said electrical dermal patch over a duration of one week, wherein each of the plurality of stimulation sessions comprises said electrical pulses, wherein at least some of the plurality of stimulation sessions have a duration of at least 15 minutes, and wherein the plurality of stimulation sessions comprises at least two occurring on different days in the week;
repeatedly applying said plurality of stimulation sessions over a predefined period of time; and
after the predefined period of time, using the plurality of programmatic instructions configured to execute on the device external to the electrical dermal patch to modify said plurality of stimulation sessions based on at least one of the data indicative of weight, the data indicative of well-being, the data indicative of hunger, the data indicative of appetite, the data indicative of calories consumed by the patient, or the data indicative of calories expended by the patient.

US Pat. No. 10,765,862

SYSTEMS AND METHODS FOR TREATING SLEEP DISORDERED BREATHING

VANDERBILT UNIVERSITY, N...

1. A method for improving obstructive sleep apnea (OSA) in a patient suffering therefrom comprising:placing an electrode into electrical communication with a target site of a nerve that is a branch of a pharyngeal nerve plexus that innervates a palatoglossus muscle, a palatopharyngeus muscle, or both of the patient, the target site of the nerve not being a cranial root of an accessory nerve of the patient; and
activating the electrode to deliver an electrical signal to the target site of the nerve to improve the patient's OSA.

US Pat. No. 10,765,861

APPARATUS AND METHOD FOR TREATING CANCER CELLS AND BACTERIA IN MAMMALS INCLUDING HUMANS

BNR Technology Developmen...

1. A method of killing bacteria in an area of roots the root of a tooth in a mammal comprising:a) positioning a first electrode adjacent a first side of a gum area where the tooth is located,
b) positioning a second electrode adjacent a second side of the gum area where the tooth is located such that the root area of the tooth is positioned between the first and second electrodes,
c) connecting a power source to the electrodes; and
d) energizing the power source to a sufficient voltage to cause current to flow from the first electrode, through the root area and the root of the tooth containing the bacteria, and to the second electrode, wherein the current passing through the root area and tooth root is between 0.1 and 0.4 amps.

US Pat. No. 10,765,859

NEURAL SLEEVE FOR NEUROMUSCULAR STIMULATION, SENSING AND RECORDING

Battelle Memorial Institu...

1. A device for neuromuscular stimulation, comprising:a reusable sleeve;
electrodes housed within the reusable sleeve; and
an inner disposable sleeve comprising a conductive medium in contact with the electrodes;
wherein the conductive medium comprises a hydrogel which is more conductive in a z-direction than in a x-direction or a y-direction.

US Pat. No. 10,765,857

CUTANEOUS ELECTRODE DEVICE AND ELECTROSTIMULATION DEVICE INCLUDING SAID ELECTRODE DEVICE

1. A cutaneous electrode device configured to be connected to an electric pulse generator, the device comprising:a planar body having an inner face configured for contacting human body, and an outer face facing away from the inner face, wherein the planar body is made from an electrically insulating material on which are formed:
at least one electrode,
at least one connecting means to the electric pulse generator, and
at least one conductive element electrically connecting said electrode to said connecting means,
wherein the at least one electrode is situated on the inner face of the body and the at least one of the connecting means in operation emerges on the outer face of the body, and wherein the body includes at least one protruding portion that extends parallel to the inner face and the outer face, and laterally away from the body, and wherein the protruding portion mechanically connects an electrode and the connecting means, and
wherein the connecting means are configured to electrically and mechanically connect, by bending the at least one protruding portion, the electrode device to the electric pulse generator,
wherein at least part of the body has an elongate shape, extending along a longitudinal axis, and including at least two protruding portions and wherein the at least two protruding portions are arranged on either side of the longitudinal axis.

US Pat. No. 10,765,856

SYSTEMS AND METHODS FOR PERIPHERAL NERVE STIMULATION TO TREAT TREMOR WITH DETACHABLE THERAPY AND MONITORING UNITS

Cala Health, Inc., Burli...

1. A system for treating tremor of a patient, the system comprising:a band comprising a first surface configured to contact skin of the patient, and comprising at least two skin electrodes, and a second surface opposite the first surface, the second surface comprising at least two receiving contacts and the band further comprising a first electrical circuit configured to be in electrical communication with both the at least two skin electrodes and the at least two receiving contacts; and
a detachable therapy unit comprising:
a second electrical circuit;
one or more sensors in electrical communication with the second electrical circuit, the one or more sensors configured to measure data from the patient;
a stimulator configured to generate an electrical stimulation, the stimulator in electrical communication with the second electrical circuit;
at least two therapy unit electrodes that are configured to receive the electrical stimulation from the stimulator, the at least two therapy unit electrodes configured to connect to the at least two receiving contacts, thereby forming an electrical pathway between the stimulator and the at least two skin electrodes;
a controller configured to control the generation of the electrical stimulation by the stimulator; and
a power source in electrical communication with the second electrical circuit;
wherein the detachable therapy unit is configured to be reversibly attached to the band.

US Pat. No. 10,765,855

BREAKER DEVICE FOR ACTING ONTO A CLOSURE ELEMENT OF A MEDICAL TUBING

Fresenius Kabi Deutschlan...

1. A breaker device for acting onto a closure element of a medical tubing, comprising:a drive arrangement having an electric drive device and a drive element driven by the drive device,
a breaker module which is arrangeable on the drive arrangement, the breaker module comprising a housing, a movable part movably arranged on the housing and a breaking element for acting onto the closure element of the tubing, wherein the breaker module in an attached state is placed on the drive arrangement, the drive element being in operative connection with the movable part in the attached state such that a movement of the drive element causes the movable part to move for actuating the breaking element, and
a control device for controlling the electric drive device for driving the drive element,
wherein the control device is constituted to control, during a detection routine, the electric drive device to drive the drive element in order to move the movable part, and wherein the control device is further constituted to analyse at least one feedback signal received during the detection routine for determining a type of the breaker module, the feedback signal being indicative of a movement of the movable part during the detection routine.

US Pat. No. 10,765,854

PORT CONNECTOR FOR MEDICAL WASTE FLUID RECEPTACLES AND METHODS OF USE

ALLEGIANCE CORPORATION, ...

1. A medical waste fluid collection system comprising:a lid provided with a first port and a second different port; and
a connector configured to connect with at least two different medical fluid container port configurations, the connector comprising:
a main body extending along a primary axis and defining a lumen, the lumen extending between a lower mouth at a lower portion of the main body and an upper mouth at an upper portion of the main body;
a first mating portion; and
a second mating portion;
wherein the first mating portion and the first port are configured to engage each other such that the lower mouth of the connector extends a predetermined distance into an interior of the medical waste fluid collection system when the connector is connected with the first port; and
wherein the second mating portion and the second port are configured to engage each other such that the lower mouth of the connector extends the same predetermined distance into the interior of the medical waste fluid collection system when the connector is connected with the second port, the second port being larger than the first port.

US Pat. No. 10,765,853

HEMOSTATIC VALVE SYSTEM

Cook Medicai Technologies...

1. A hemostatic valve assembly comprising:a housing comprising a proximal end, a distal end and a side wall defining a housing chamber between the proximal and distal ends, wherein at least a portion of the housing side wall tapers radially inwardly in a proximal to distal direction to form a continuously curved inner surface;
a tubular sheath extending proximally from the housing and comprising a proximal end and a distal end and a sheath lumen extending therebetween;
a valve member disposed at least partially within the housing chamber, the valve member comprising an open proximal end, a distal end having an orifice formed therein, a side wall extending between the proximal and distal ends of the valve member to form a valve cavity, and a continuously curved outer surface, the valve member being deformable between a closed configuration in which the orifice is substantially closed and an open configuration in which the orifice is open; and
a biasing member disposed proximal to the valve member and moveable between a longitudinally compressed condition and a longitudinally expanded condition,
wherein, when in the longitudinally expanded condition, the biasing member is configured to push the valve member longitudinally and against the continuously curved inner surface of the side wall of the housing,
wherein the continuously curved inner surface of the side wall of the housing is configured to urge at least the distal end of the valve member radially inwardly, thus urging the orifice to a substantially closed configuration,
wherein the housing comprises an open aperture at its distal end such that an interventional device may be introduced proximally through the open aperture, advanced through the orifice, advanced through the housing chamber, and into the sheath, and
wherein the orifice of the valve member is biased in the closed configuration and wherein when the orifice of the valve member is biased in the closed configuration, the open aperture is open.

US Pat. No. 10,765,852

VALVE BODY, PROCESS FOR PRODUCING THE VALVE BODY, AND MEDICAL INSTRUMENT INCLUDING THE VALVE BODY

TERUMO KABUSHIKI KAISHA, ...

1. A process for producing a valve body comprising an opening/closing part which opens upon inserting a member into the opening/closing part and which closes upon withdrawing the member from the opening/closing part, the process comprising:forming a surface layer comprised of silicon oxide at least in a region that includes the opening/closing part;
wherein the surface layer is comprised of silicon oxide formed on a surface of a base material, the base material comprising a silicone rubber; and
wherein the forming of the surface layer of silicon oxide comprises irradiating at least a region of a surface of the opening/closing part with a laser beam so that the silicone rubber in the region is modified into silicon oxide and raised.

US Pat. No. 10,765,851

METHODS AND SYSTEMS FOR MATERIAL TRANSPORT ACROSS AN IMPERMEABLE OR SEMI-PERMEABLE MEMBRANE VIA ARTIFICIALLY CREATED MICROCHANNELS

Guided Therapy Systems LL...

1. A method for transporting a medicant across a stratum corneum layer of a skin and into a dermis layer of the skin, the method comprising:a) contacting a top surface of the stratum corneum layer with the medicant;
b) creating a microchannel in the stratum corneum layer, the microchannel providing fluid communication between the top surface of the stratum corneum layer and an epidermis layer of the skin;
c) after creating the microchannel, directing a first acoustic energy field from an acoustic energy source or a first photon-based energy field from a photon-based energy source to the medicant, thereby driving the medicant through the microchannel and into the epidermis layer of the skin, the first acoustic energy field is a pulsed first acoustic energy, has a pulse width of 33 nanoseconds to 5 seconds, a frequency of 1 MHz to 30 MHz, and a peak intensity of 5 W/cm2 to 70 kW/cm2, and generates a pressure of 10 kPa to 100 MPa, thereby initiating acoustic streaming or inertial cavitation that drives the medicant through the microchannel and into the epidermis layer of the skin; and
d) subsequent to the medicant being driven into the epidermis layer of the skin, applying a second acoustic energy field to the medicant, thereby driving the medicant from the epidermis layer of the skin and into the dermis layer of the skin wherein step b) includes puncturing the stratum corneum layer with a microneedle to create the microchannel in the stratum corneum layer.

US Pat. No. 10,765,850

METHODS AND SYSTEMS FOR TRANS-TISSUE SUBSTANCE DELIVERY USING PLASMAPORATION

GOJO INDUSTRIES, INC., A...

1. An apparatus for providing a substance associated with a skin treatment, comprising:a treatment patch applied to skin associated with the skin treatment, wherein the treatment patch comprises:
a substrate that flexibly conforms to a shape of the skin; and
a substance reservoir for holding a treatment substance associated with the skin treatment; and
a plasma generating device for generating a plasma;
a power supply for powering the plasma generating device; and
first circuitry for providing one or more electrical pulses to the plasma generating device;
wherein the plasma generating device and the treatment patch are configured to apply the plasma and the treatment substance to the skin during the skin treatment.

US Pat. No. 10,765,849

SKIN ANTISEPTIC APPLICATOR AND METHODS OF MAKING AND USING THE SAME

Medline Industries, Inc.,...

1. A method of making an aseptic applicator comprising the steps of:(a) molding an extruded polymer material by placing a blow pin into a first end of the extruded material and using pressure to form the material into a container body shape comprising a neck portion having a plurality of outwardly extending protrusions at the first end and a substantially hollow handle at a second end;
(b) filling said container body at the first end, using said blow pin, with an aseptic composition comprising: (i) an antimicrobial agent and (ii) an alcohol;
(c) retracting said blow pin, creating a frangible member at the first end having one or more wings extending toward the second end and adjacent the outwardly extending protrusions of the neck portion of the container body, and sealing the filled container body at the first end, the frangible member and filled container body being a sealed unitary structure of said polymeric material;
(d) attaching a porous applicator head to said unitary structure at the first end to form the aseptic applicator; and
(e) retaining the porous applicator head with the one or more wings which extend adjacent to the neck portion of the container body.

US Pat. No. 10,765,848

DEVICE AND FORMULATION FOR TOPICAL TREATMENT OF PAIN AFFECTING THE VULVAR AREA OF THE FEMALE HUMAN GENITAL ORGAN

GRUENENTHAL GMBH, Aachen...

1. A device for the topical treatment of pain affecting the vulvar area of the female human genital organ, wherein the device is a layered article shaped to be placed in use inside a female undergarment and at least partially in skin contact with the female vulvar area, said article having a longitudinal direction, a transverse direction, a front end, a back end, and two longitudinal sides, and said device comprises at least:a) a formulation-impermeable outer layer having an outer surface and an inner surface;
b) a formulation-impermeable rim layer, wherein said formulation-impermeable rim layer is superimposed on the inner surface of the formulation-impermeable outer layer and does not cover an inner section thereof thereby defining a channel extending in the longitudinal direction of the article;
c) a carrier layer having an inner carrier surface and a skin-contacting surface, said carrier layer being superimposed on the formulation-impermeable rim layer and the channel such that the inner carrier surface faces in a direction of the formulation-impermeable rim layer and the channel;
d) a topical formulation comprising at least one active agent for treating pain affecting the vulvar area of the female human genital organ;
wherein the carrier layer is at least partially impregnated with the topical formulation and/or at least one dispensing unit is positioned interposed between the formulation-impermeable outer layer and the formulation-impermeable rim layer adjacent to the channel and said dispensing unit contains a topical formulation to be released into the channel.

US Pat. No. 10,765,847

SINGLE LUMEN DRAINAGE CATHETER WITH EXTENDABLE AND RETRACTABLE DRAINS

1. A catheter, comprising:a primary drainage catheter comprising a housing with a common drain, the primary drainage catheter providing continuous fluid drainage from a patient;
wherein the housing has a distal end portion, a proximal end portion, an exterior, and an interior space comprising a single unpartitioned lumen;
wherein the common drain is coupled to the proximal end portion of the housing and is adapted for a fluid to flow through the common drain, wherein the common drain is attached the exterior portion of the housing; and
a plurality of drains arranged within the single unpartitioned lumen with each drain of the plurality of drains having a proximal end, a distal end, and an interior space between the proximal end and the distal end, wherein each drain of the plurality of drains is adapted for the fluid to flow through the interior space between the proximal end and the distal end;
wherein the common drain is in fluid communication with the single unpartitioned lumen of the interior space of the housing and with the plurality of drains;
wherein the plurality of drains are adapted to be movable within the single unpartitioned lumen between an extended position with at least the distal end portions of the plurality of drains extending to the exterior of the housing and a retracted position with the plurality of drains being enclosed within the single unpartitioned lumen of the housing; and
wherein with the plurality of drains in the extended position the plurality of drains provide a first plurality of paths for the fluid to flow between the common drain and the exterior of the housing;
an internal connector having a proximal end portion, a proximal end surface, a distal end portion, and a distal end surface, wherein:
the internal connector is enclosed within the single unpartitioned lumen and is selectively movable within the single unpartitioned lumen substantially between the proximal end portion of the housing and the distal end portion of the housing;
the plurality of drains are coupled to the internal connector with the proximal ends of the plurality of drains coupled to the distal end portion of the internal connector and the distal end of the drains extending into the single unpartitioned lumen; and
movement of the internal connector between the proximal end portion of the housing and the distal end portion of the housing causes the plurality of drains to move between the retracted position and the extended position; and,
an elongated stylet having a proximal end portion, a distal end portion, and a distal end tip.

US Pat. No. 10,765,846

METHODS AND SYSTEMS FOR DRAINING CEREBROSPINAL FLUID INTO THE VENOUS SYSTEM

CereVasc, Inc., Auburnda...

1. A system for treating a patent, the system comprising:a cerebrospinal fluid shunt configured for deployment through a venous system of the patient, the shunt comprising a proximal portion, a distal portion having a distal anchoring mechanism, and a shunt lumen in fluid communication with one or more distal openings in the distal portion and one or more proximal openings in the proximal portion; and
a delivery system configured for creating an anastomosis between an inferior petrosal sinus and a CSF-filled subarachnoid space of the patient, and for deploying the shunt in the anastomosis with the distal portion of the shunt positioned in the subarachnoid space, such that, when the shunt is deployed in the anastomosis, CSF flows from the subarachnoid space through the one or more distal openings, lumen, and one or more proximal openings of the shunt, respectively, into the venous system of the patient.

US Pat. No. 10,765,844

MEDICAL FLUID DRAINAGE SYSTEM

ECOLE POLYTECHNIQUE FEDER...

1. A medical fluid drainage system for draining a fluid from an edematous space of a subcutaneous area of a living body comprising:N pumps, N being an integer number that is larger or equal to 2, the N pumps connected in series, the integer number N pumps limited by a size of the subcutaneous area for accommodating the N pumps, each having an inlet and an outlet;
a first inlet member connected to the inlet of a first pump;
N?1 inlet members providing fluidic connections between the N pumps;
an outlet member connected to the outlet of a last pump; and
a controller configured to provide a coordinated operation of the N pumps to provide for a fluid flow from the first and the N?1 inlet members towards the outlet member,
wherein the N pumps, the first inlet member, the N?1 inlet members, and outlet member forming a fluid line,
wherein each of the N?1 inlet members includes an entry point configured to allow the fluid to directly enter the fluid line,
wherein the outlet member includes an exit point configured to allow the fluid to directly exit the fluid line, and
wherein the controller is configured to control the N pumps such that first a pump among the N pumps located the most downstream is activated while remaining pumps of the N pumps are closed, and thereafter repeatedly activating a neighboring pump located upstream while keeping downstream pumps open.

US Pat. No. 10,765,843

INTRAVASCULAR DEVICES, SYSTEMS, AND METHODS TO ADDRESS EYE DISORDERS

1. A method, comprising:percutaneously accessing a superficial temporal artery of a subject;
advancing a device in a retrograde direction within the superficial temporal artery of the subject;
advancing the device in the retrograde direction within an external carotid artery of the subject;
advancing the device within a carotid bifurcation of a common carotid artery of the subject; and
advancing the device in an antegrade direction within an internal carotid artery of the subject toward an ostium between an ophthalmic artery and the internal carotid artery.

US Pat. No. 10,765,842

EXPANDABLE MEDICAL DEVICES

1. A medical device, comprising:an elongated tubular body having proximal and distal ends;
an expandable element at the distal end of the elongated tubular body, the expandable element being configured to be actuated to exert a first expansion pressure and a second expansion pressure that is greater than the first expansion pressure; and
an expandable tubular sleeve including a first end portion, a second end portion, and a middle portion between the first and second end portions, the expandable tubular sleeve disposed about the expandable element such that the expandable tubular sleeve can be fully expanded and retracted in association with the expandable element, the first end portion of the expandable tubular sleeve having a first radial strength and the middle portion of the expandable tubular sleeve having a second radial strength that is less than the first radial strength, wherein the expandable element has a sequence of expansion dictated only by the first and second radial strengths of the expandable tubular sleeve such that the middle portion of the expandable tubular sleeve expands first in response to applying the first expansion pressure to the expandable tubular sleeve and the first end portion of the expandable tubular sleeve expands subsequently in response to applying the second expansion pressure to the expandable tubular sleeve that is greater than the first expansion pressure, and wherein the first radial strength of the first end portion is defined by an amount of longitudinal compression of the first end portion such that the first end portion is characterized by a first compression ratio and the second radial strength of the middle portion is defined by an amount of longitudinal compression of the middle portion such that the middle portion is characterized by a second compression ratio that is lower than the first compression ratio.

US Pat. No. 10,765,840

CONTENT INFLATION AND DELIVERY SYSTEM

1. A content inflation and delivery system comprising:a container including (a)(i) a first end with a first end diameter and a second end with a second end diameter, (a)(ii) an inner surface and an outer surface, and (a)(iii) a vertical axis between the first end and the second end;
a hollow shaft including (a)(i) a first shaft end comprising a fluid inlet configured to receive a fluid and (a)(ii) a second shaft end configured to deliver the fluid;
wherein the hollow shaft is movable through the container along the vertical axis;
a fluid outlet comprising or coupled to the second shaft end;
a content inlet;
an inflatable content, a proximal end of the inflatable content being coupled to a distal end of the content inlet, the content inlet including a proximal end that is selectively coupled to the second shaft end, the proximal end of the content inlet being positioned more proximate to the first end of the container than the distal end of the content inlet, wherein a body of the content inlet has a body diameter and the distal end of the content inlet having a distal end diameter, the distal end diameter being smaller than the body diameter;
wherein the content inlet has an outer surface, the outer surface of the content inlet being configured to be positioned directly adjacent to the container while the inflatable content moves between the first end and the second end of the container; and
wherein the inflatable content is in fluid communication with the fluid outlet and the hollow shaft, the proximal end of the inflatable content having a diameter that is smaller than a proximal end diameter of the content inlet;
a clip positioned on the hollow shaft configured to limit the movement of the hollow shaft within the container, the clip having a clip diameter that is larger than the first end diameter of the container, the clip always being proximal to the container's first end.

US Pat. No. 10,765,838

MEDICAL DEVICE, MEDICAL DEVICE ASSEMBLY, BALLOON DEVICE, AND TREATMENT METHOD FOR TREATING URETHRAL STRICTURE

TERUMO KABUSHIKI KAISHA, ...

1. A medical system comprising:a medical device and a medical member, the medical device configured to deliver the medical member, the medical device comprising:
a flexible main body that extends in an axial direction;
a balloon that includes a dilatable portion on which the medical member is mounted, the balloon having a dilating space into which a pressurizing medium flows between an outer surface of the flexible main body and an inner surface of the balloon;
an elongated guide member configured to extend across the treatment target site and outside of a living body via the biological lumen;
an attachment portion to which at least a portion of the guide member is detachably attached to the flexible main body at a position between end portions of the flexible main body in the axial direction;
the flexible main body being configured to be movable inside the biological lumen along a route having the elongated guide member arranged in the flexible main body, in a state where the guide member is attached to the attachment portion, the flexible main body having a lumen which extends in the axial direction, an opening portion for inserting the guide member into the lumen, and a hole portion configured to guide the guide member from the lumen to an outside of the flexible main body, and an extracting portion configured to guide the guide member from the hole portion to an outer surface side of the balloon, the extracting portion having a through-hole disposed in the balloon, and wherein a portion of an outer surface of the balloon around the through-hole is fixed to a periphery of the hole portion of the flexible main body; and
wherein the medical member is a sheet shaped member configured to provide a biological tissue with an epithelial function, and wherein the sheet shaped member is configured to be introduced into the biological lumen in a state where the sheet shaped member is wound around the dilatable portion of the balloon, and a gap in the sheet shaped member through which the guide member can be inserted in a state in which the sheet shaped member is wrapped around the dilatable portion of the balloon in a circumferential direction; and
a puncture tool including a main body having a lumen configured to receive the guide member and a puncture needle to which the guide member is attached so as to be connectable to the puncture needle and detachable from the puncture needle.

US Pat. No. 10,765,837

METHOD AND DEVICE FOR SHEATHLESS ARTERIAL CATHETERIZATION

Cardinal Health Switzerla...

1. A kit for gaining access to a vessel of a patient, comprising:a first dilator having an elongated body with proximal and distal ends, a distal portion with a maximal outer diameter having a cylindrical configuration that extends from the distal end to a guidewire exit port, a proximal portion with a reduced profile having a semi-cylindrical configuration that extends from the guidewire exit port to the proximal end and a lumen defined by an inner wall that extends between the distal end and the guidewire exit port, wherein a portion of the inner wall continues to extend through the proximal portion; and
a second dilator having an elongated body with proximal and distal ends, a distal portion with a maximal outer diameter having a cylindrical configuration that extends from the distal end to a guidewire exit port, a proximal portion with a reduced profile having a semi-cylindrical configuration that extends from the guidewire exit port to the proximal end and a lumen defined by an inner wall that extends between the distal end and the guidewire exit port, wherein a portion of the inner wall continues to extend through the proximal portion;
wherein the first dilator is configured to be inserted into a radial artery, and the second dilator is configured to be inserted into the radial artery upon removal of the first dilator;
wherein the lumen of the first dilator has a smaller inner diameter than the lumen of the second dilator; and
wherein the maximal outer diameter distal portion of the first dilator has an outer diameter the same as the maximal outer diameter distal portion of the second dilator.

US Pat. No. 10,765,836

ELECTRONIC GUIDEWIRE DETECTOR FOR CATHETER INSERTION

HORIZON PATENTS, LLC., F...

1. A detector for a guidewire to be used with a catheter, comprising:a housing including a passageway having a first opening on a patient side of the housing and a second opening on a caregiver side of the housing; and
circuitry contained within the housing for detecting and indicating: (1) that a first end of the guidewire has not yet entered the housing through the first opening on the patient side, (2) that the first end of the guidewire has entered the housing through the first opening on the patient side and a second end of the guidewire has not passed through the second opening on the caregiver side and (3) that the second end of the guidewire has been removed from the housing through the second opening on the caregiver side having previously entered through the first opening on the patient side.

US Pat. No. 10,765,834

URETERAL AND BLADDER CATHETERS AND METHODS OF INDUCING NEGATIVE PRESSURE TO INCREASE RENAL PERFUSION

Strataca Systems Limited,...

1. A method for facilitating urine output from the kidney, comprising:(a) inserting a catheter into at least one of a patient's kidney, renal pelvis or in the ureter adjacent to the renal pelvis, wherein the catheter comprises:
a drainage lumen comprising a distal portion configured to be positioned in a patient's kidney, renal pelvis and/or in the ureter adjacent to the renal pelvis and a proximal portion, the distal portion comprising a retention portion comprising a funnel support comprising at least one sidewall, wherein the funnel support comprises a first diameter and a second diameter, the first diameter being less than the second diameter, the second diameter being closer to an end of the distal portion of the drainage lumen than the first diameter, wherein the funnel support is free of a balloon, wherein the proximal portion of the drainage lumen is essentially free of or free of openings; and
(b) applying negative pressure to the proximal portion of the drainage lumen for a period of time to facilitate urine output from the kidney.

US Pat. No. 10,765,833

URINARY CATHETER ASSEMBLIES WITH FUNNEL-MOUNTED GRIPPING MEMBER

Hollister Incorporated, ...

1. A urinary catheter assembly, comprising:a catheter shaft extending between proximal and distal ends;
a drainage funnel associated with the distal end of the catheter shaft; and
a gripping member extending between proximal and distal ends, wherein
the distal end of the gripping member is fixedly secured to the drainage funnel,
an extendable portion of the gripping member is configured to allow the proximal end of the gripping member to be moved along the length of the catheter shaft toward and away from the proximal end of the catheter shaft,
the extendable portion of the gripping member encircles at least a portion of the catheter shaft when the proximal end of the gripping member is moved toward the proximal end of the catheter shaft, and
the extendable portion of the gripping member is resilient and consists only of a helix or a lattice structure arranged in a tube around the catheter shaft.

US Pat. No. 10,765,832

MEDICAL TUBING HAVING VARIABLE CHARACTERISTICS AND METHOD OF MAKING SAME

Applied Medical Resources...

1. A method of manufacturing a multi-lumen tube, comprising:coating a first wire with a plastic material;
winding the coated first wire around a first mandrel, thereby forming a plurality of windings in a first wound coated wire;
coating a second wire with a plastic material;
winding the coated second wire around a second mandrel, thereby forming a plurality of windings in a second wound coated wire;
placing a compression sleeve over the second wound coated wire and the first wound coated wire to compress the second wound coated wire against the first wound coated wire prior to heating; and
heating the second wound coated wire and the first wound coated wire in the compression sleeve until the plastic material fuses the windings such that a second wire-reinforced tube is formed next to a first wire-reinforced tube as the multi-lumen tube.

US Pat. No. 10,765,830

SLEEP APNEA TREATMENT SYSTEM AND IMPROVEMENTS THERETO

FRESCA Medical, Inc., Sa...

1. A valve structure for treating a patient suffering from obstructive sleep apnea, the valve structure adapted to be connected to an air flow generator and connected to a mask that covers at least the nostrils of a patient, the valve structure comprising:a housing with an inlet pressure port configured to be connected to the air flow generator, and an ambient pressure port, within the housing: an expiratory membrane, an expiratory valve seat, an inspiratory membrane, an inlet pressure valve seat, an inspiratory valve seat, and an inspiratory membrane segmentation structure configured to segment the movement of the inspiratory membrane into at least a first portion and a second portion;
an expiratory valve in fluid connection with the inlet pressure port, formed by the expiratory membrane and the expiratory valve seat;
an inlet pressure valve formed by the inlet pressure valve seat and the first portion of the inspiratory membrane, wherein the inlet pressure valve is constructed to allow air flow from the inlet pressure port into the mask with little resistance and to block air flow from within the mask to the inlet pressure port; and
an inspiratory valve formed by the inspiratory valve seat and the second portion of the inspiratory membrane, wherein the inspiratory valve is constructed to allow air flow from the ambient pressure port into the mask with little resistance and to block air flow from within the mask to the ambient pressure port.

US Pat. No. 10,765,829

DELIVERY OF GASES TO THE NASAL AIRWAY

OptiNose AS, Oslo (NO)

1. A method of delivering an uptake enhancing gas and a substance to a nasal airway of a subject comprising:fitting a nosepiece into one nostril of the subject;
fitting a mouthpiece into a mouth of the subject, the mouthpiece fluidly connected to the nosepiece and configured to permit the subject to cause a flow of exhaled breath through the mouthpiece and through the nosepiece;
causing the substance to be delivered into the flow of exhaled breath; and
causing the uptake enhancing gas to be delivered into the flow of exhaled breath;
wherein the uptake enhancing gas is carbon dioxide.

US Pat. No. 10,765,828

ADJUSTABLE TENSION DEVICE FOR CPAP MASK

Koninklijke Philips N.V.,...

1. A respiratory interface device comprising:a faceplate including an inner surface and an outer surface;
a cushion including a resilient body, the body including a center, a centerline, and an engagement portion structured to engage a user's face, wherein the cushion body is coupled to the faceplate;
a cushion tension assembly including an adjustment assembly and a number of tension members,
wherein each tension member is operatively coupled to the adjustment assembly,
wherein each tension member is operatively coupled to the cushion body, and
wherein the adjustment assembly is structured to move the cushion body between a first configuration in which the cushion body provides a generally continuous seal, and a second configuration in which the cushion body provides a more complete seal;
wherein the adjustment assembly is coupled to the faceplate,
wherein the adjustment assembly includes a number of actuating devices and number of tension member couplings, and
wherein each tension member coupling is coupled to a tension member,
wherein each tension member coupling is operatively coupled to at least one actuating device,
wherein each actuating device is disposed adjacent the faceplate outer surface, and wherein each tension member coupling is disposed adjacent the faceplate inner surface,
wherein the cushion body includes a number of tension member couplings,
wherein each cushion body tension member coupling includes an associated selected portion of the cushion body,
wherein the adjustment assembly is structured to move the cushion body between the first configuration in which the cushion body tension member coupling selected portion of the cushion body is a first distance from one of the cushion body center or cushion body center line, and the second configuration in which the cushion body tension member coupling selected portion of the cushion body is a second distance from one of the cushion body center or cushion body centerline.

US Pat. No. 10,765,825

ENDOTRACHEAL TUBE DRAINAGE SYSTEM AND METHODS

CORESTONE BIOSCIENCES (BE...

1. An endotracheal tube (ETT) system, comprising:a tube;
an inflatable cuff coupled to the tube; and
a restrictor comprising one or more cavities, the restrictor surrounding the tube, wherein the inflatable cuff is positioned between the restrictor and the tube, and wherein the restrictor restricts the inflatable cuff to form a valley positioned between two protruding regions of the inflatable cuff upon inflation of the inflatable cuff.

US Pat. No. 10,765,824

PATIENT INTERFACE COMPRISING A GAS WASHOUT VENT

ResMed Pty Ltd, Bella Vi...

1. A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least the patient's nares, wherein the patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout the patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing, said patient interface comprising:a sealing structure configured to seal against an area of the patient's face surrounding an entrance to the patient's airways;
a plenum chamber connected to the sealing structure and configured to be pressurized to the therapy pressure in use;
a positioning and stabilizing structure configured to maintain the sealing structure in sealing contact with the patient's face in use;
a gas washout vent configured to allow a vent flow of gas to exit the plenum chamber to atmosphere to minimize rebreathing of exhaled gas by the patient, said gas washout vent comprising:
a first layer having a plurality of first ellipsoidal structures arranged in rows and columns to form a plurality of first openings in a first grid; and
a second layer having a plurality of second ellipsoidal structures arranged in rows and columns to form a plurality of second openings in a second grid,
wherein the first layer and the second layer are permanently attached to one another such that the first openings and the second openings are offset relative to each other to form a plurality of constricted passages extending through the first openings and the second openings of the first layer and the second layer, respectively, to allow the vent flow of gas to pass through the gas washout vent to atmosphere.

US Pat. No. 10,765,823

CONTROL DEVICE FOR MEDICAL VENTILATORS

Shenzhen Mindray Bio-Medi...

1. A control device for a medical ventilator, the control device having a user definable medical ventilator protocol, wherein the control device includes:means for selecting a plurality of objects from a group of objects, at least one object of the plurality of objects comprising a wean object configured to wean a patient from the medical ventilator, wherein each of the objects are segments of the ventilator protocol, at least one of the objects having at least one static attribute and at least one dynamic attribute, wherein each static attribute maintains a particular value during the execution of the ventilator protocol, and wherein each dynamic attribute has a value that is updated during the ventilator protocol responsive to sensor data;
means for arranging the plurality of objects in a sequence, wherein at least one object of the plurality of objects in the sequence refers to itself or another object to create a loop that must be performed before executing the wean object to wean the patient from the medical ventilator;
a processor unit; and
a non-transitory computer readable storage medium comprising instructions which, when executed by the processor unit, cause the processor unit to:
initiate the at least one attribute to define a property for each object in the plurality of objects, and
execute the sequence.

US Pat. No. 10,765,822

ENDOTRACHEAL TUBE EXTUBATION DETECTION

COVIDIEN LP, Mansfield, ...

1. A ventilator-implemented method for detecting extubation of an endotracheal tube during ventilation, the method comprising:determining, by the ventilator based on measurements from one or more sensors, a first volume of breathing gas delivered to a patient during a first inspiratory period;
determining, by the ventilator based on measurements from the one or more sensors, a second volume of breathing gas delivered to a patient during a second inspiratory period;
determining, by the ventilator, a difference between the first volume and the second volume;
comparing, by the ventilator, the determined value for the difference between the first volume and the second volume to a threshold; and
activating, by the ventilator, an alarm indicating extubation of the endotracheal tube when the determined value for the difference is greater than the threshold.

US Pat. No. 10,765,820

DRY POWDER INHALATION APPARATUS

NORTON HEALTHCARE LTD., ...

1. A dry powder inhalation apparatus, comprising:a housing,
a reservoir for medicament located within the housing,
a mouthpiece disposed on the housing for insertion in the mouth of a user for inhalation of a predetermined dose of medicament, a delivery channel between a discharge outlet of the reservoir and the mouthpiece for delivering said predetermined dose of medicament,
a device positioned within the housing and normally held adjacent the reservoir for receiving said predetermined dose of medicament from said discharge outlet and transferring it to the delivery channel, and
a release mechanism adapted to release the device and permit controlled movement thereof to the delivery channel for said delivery, the release mechanism being located at least partially outside of the housing for manual operation by the user,
wherein the release mechanism comprises an abutment which is movable transversely to a longitudinal axis of the apparatus to be clear of an end of the device to release the device for movement to the delivery channel.

US Pat. No. 10,765,819

DOSE COUNTING MECHANISM

Newtec Pro Manufacturing ...

1. A dose counting mechanism for indicating the quantity of dosage available within an inhaler, the inhaler having a canister with an aerosol fluid therein and an actuator including a housing body with an elongate cavity for housing the canister therein, the housing body having a top end and a bottom end and defining a vertical axis therethrough, the housing body including a mouth piece extending from the bottom end, a stem extending axially from the mouth piece into the housing body, the stem having a sump defined therein and a passage with an orifice defined therethrough such that the stem and the sump are configured to receive a spring loaded valve of the aerosol loaded canister and to dispense a pre-measured dose of aerosol via the stem and the orifice into a mouth of a user, the dose counting mechanism comprising:a wall of the housing body further comprising,
an outer surface defining a slit opening within the elongate cavity of the housing body,
a pair of pads formed on the outer surface of the wall on either side of the slit opening and above the slit opening,
a rail formation, a first guide bracket and a second guide bracket formed on the outer surface of the wall;
said dose counting mechanism further comprising:
a central elongate member,
a resilient element defined by:
resiliently displaceable arms extending on either side of the central elongate member,
a key member configured at the bottom of said central elongate member, a first nose integral with said key member extending operatively inwardly from one side of said central elongate member,
wherein in an operative configuration of said dose counting mechanism, said first nose extends through said slit opening into the elongate cavity of the housing body and engages with a head of the canister to be displaced within said slit opening in an event that the canister is depressed by the user, an upper end of said central elongate member slides in said second guide bracket, and ends of said resiliently displaceable arms resiliently deform and slide on said pads; and
a pusher configured below one of said arms and extending from said central elongate member, said pusher having a second pushing nose;
a wheel formation with a first operative side and a second operative side having a ratchet wheel formation surrounding an axle integral to said wheel formation on the first operative side and a first bevel gear formation on the second operative side, such that in the operative configuration of said dose counting mechanism said wheel formation is positioned on the outer surface of said wall with said ratchet wheel proximal to the outer surface of the wall and said first bevel gear distal from the outer surface of said wall, said second pushing nose engages said ratchet wheel to angularly displace said ratchet wheel tooth by tooth in one direction, wherein a pawl mechanism engages said ratchet wheel to prevent a reverse movement of said ratchet wheel;
an elongate threaded element having a second bevel gear formation extending from an operative lower end of said elongate threaded element and configured to engage said first bevel gear in the operative configuration of said dose counting mechanism, wherein the gear ratio between said first and second bevel gears is such that a movement of one tooth of said ratchet wheel angularly displaces both said first and second bevel gears by one tooth each, thereby causing rotational movement of said elongate threaded element by one pitch;
a threaded formation configured to engage with the threads of said elongate threaded element, and a pointer extending from said threaded formation, said threaded formation being displaceable along said elongate threaded element in response to the rotational movement of said elongate threaded element; and
a first cover element is press fitted on said wall to secure the arrangement of said dose counting mechanism thereon, and a second cover element is press fitted on said wall over said first cover element.

US Pat. No. 10,765,818

DRY POWDER INHALER

Vectura Delivery Devices ...

1. A dry powder inhaler comprising a housing to receive a single blister containing a dose of medicament for inhalation by a user, said blister comprising a blister lid attached to a blister bowl, said blister having a middle portion and two spaced apart portions, said blister bowl having a circumference, a mouthpiece through which the dose of medicament is inhaled by the user and a blister opening device, the blister opening device comprising a blister support element for supporting the middle portion of the blister containing the dose of medicament for inhalation by the user, and a blister folding element co-operable with the blister support element, the blister folding element and the blister support element being moveable relative to each other between a first position, for insertion of said middle portion of the blister into or onto the blister support element, and a second position in which the blister folding element has co-operated with the blister support element, movement from the first position to the second position causing the two spaced apart portions of said blister to fold relative to the middle portion of the blister along two respective fold lines and against the blister support element to produce two spaced apart openings, each opening extending along a portion of the circumference of the blister bowl, beginning and terminating at points located on the respective fold line such that, when the user inhales through the mouthpiece, an airflow through the blister via the two openings is generated to entrain the dose contained therein and carry the dose out of the blister and via the mouthpiece into the user's airway, wherein the blister folding element is not configured to cut, slice or pierce the blister, and wherein the two spaced apart openings are formed between the blister lid and the blister bowl and are formed by separation of the blister lid from the blister bowl.

US Pat. No. 10,765,816

SAFETY SYRINGE AND METHODS OF MAKING AND USING SAME

1. A syringe safety device, comprising:a shaft configured to support a barrel of a syringe, the shaft having an elongated wall with a first aperture, and a second aperture longitudinally spaced from the first aperture,
a guard configured to be disposed inside the shaft before the syringe is used and to extend outwardly from the shaft after the syringe is used, and
a lock disposed between the guard and the shaft, the lock having a lock head disposed at a first end thereof, the lock head being disposed in the first aperture before the syringe is used and in the second aperture after the syringe is used.

US Pat. No. 10,765,815

RETRACTABLE NEEDLE SYRINGE

L.O.M. Laboratories Inc.,...

1. A retractable-needle syringe comprising:a syringe barrel;
a plunger slidably disposed within and sealingly engaged with the syringe barrel, the plunger having a retraction lumen defined therein for receiving a needle when the retractable-needle syringe is actuated;
the needle coupled to a distal end of the syringe barrel and in fluid communication with a medicament chamber defined within the syringe barrel distally of the plunger;
a needle hub for securing the needle at the distal end of the syringe barrel, the needle hub being initially secured within a false wall against a loading force or an injection force applied by a user, and releaseable from the false wall in response to a post-injection force applied by the user;
a locking tip provided at a distal end of the plunger, the locking tip being in sealing engagement with and initially secured within the retraction lumen against the loading force or the injection force applied by the user, and releasable for sliding retraction within the retraction lumen in response to release of propellant upon the post-injection force applied by the user, the locking tip being engageable with the needle hub in response to the post-injection force to provide a retraction assembly comprising the locking tip, the needle hub, and the needle;
a propellant release cell positioned distally of the needle hub and containing the propellant; and
a rupture mechanism positioned to puncture the propellant release cell in response to application of the post-injection force by the user to thereby drive retraction of the retraction assembly within the retraction lumen,
wherein the needle hub comprises a tapered sealing portion on an inner surface of the needle hub at a proximal portion of the needle hub, a proximal end of the tapered sealing surface being wider than a width of the tapered sealing surface at any point distal to the proximal end of the tapered sealing surface, and wherein the locking tip of the plunger comprises a central projection with a tapered surface that is complementary to the tapered sealing portion of the needle hub, so that the tapered sealing portion and the tapered surface can be brought together into sealing contact upon the application of the post-injection force; and
wherein the false wall comprises a central aperture extending axially therethrough, and a radially-outwardly projecting channel defined circumferentially on an interior portion of the central aperture, and wherein the needle hub comprises radially outwardly projecting engagement features for initially sealingly engaging with the channel, the engagement features being displaceable from the channel in response to the application of the post-injection force by the user.

US Pat. No. 10,765,814

SAFETY SYRINGE ASSEMBLY

1. A safety syringe assembly comprising:a) a needle having a bevel;
b) a needle hub assembly including said needle disposed in a hub flex unit, said hub flex unit being mounted upon a needle hub, said needle hub retaining said needle mounted in a secure manner, said hub flex unit including a flex arm; and
c) a safety cover, said needle and said needle hub assembly being disposed within said safety cover, said safety cover including a window, said flex arm cooperatively engaging with said window to prevent said needle hub assembly from sliding within said safety cover during shipping, filling of said safety syringe assembly with medical fluid being initiated by pressing said flex arm into said window of said safety cover;
i. said needle hub assembly being securely positionable within said safety cover in a shipping position, said shipping position of hub flex unit having a first diameter;
ii. said needle hub assembly being securely positionable within said safety cover in an insertion position, said insertion position being for needle insertion, said insertion position being different from said shipping position, said insertion position of said hub flex unit having a second diameter; and
iii. said needle hub assembly being securely positionable within said safety cover in a disposal position for disposal after said needle has been used, said disposal position being different from said insertion position and said shipping position, said disposal position of said hub flex unit having a third diameter.

US Pat. No. 10,765,813

SELF INJECTION DEVICE WITH MULTI-POSITION CAP

Becton, Dickinson and Com...

1. A self-injection device, comprising:a pen needle;
a pen body connectable to the pen needle; and
a cap connectable directly to a first end of the pen body:
in a first orientation with respect to the pen body to render a length or volume of the self-injection device insufficient to house the pen needle connected to the pen body; and
in a second orientation to provide sufficient length or volume in an interior of the cap to house the pen needle connected to the pen body.

US Pat. No. 10,765,812

CONVERTIBLE PLUNGERS AND METHODS FOR ASSEMBLING THE SAME IN A MEDICAL BARREL

SIO2 MEDICAL PRODUCTS, IN...

1. A convertible plunger comprising:a. an internal portion and a generally cylindrical exterior surface that surrounds at least part of the internal portion;
b. the generally cylindrical exterior surface comprising a compressible and resilient storage sealing section that is maintained in an expanded state by outward radial pressure provided by the internal portion;
c. the internal portion being comparatively more rigid than the storage sealing section;
d. the expanded state being reducible to a constricted state by an operation that is applied to the internal portion of the plunger to reduce or eliminate the outward radial pressure;
e. the storage sealing section in the constricted state:
i. having a reduced maximum diameter or cross-sectional width than the storage sealing section in the expanded state; and/or
ii. being less resistant to inward radial compression compared to the storage sealing section in the expanded state;
f. wherein the storage sealing section is configured to be initially disposed in its entirety within a medical barrel while in a load position in which the storage sealing section is configured not to contact the medical barrel or to have reduced compression against the medical barrel compared to when the storage sealing section is in the expanded state, wherein the storage sealing section is configured to be set in the expanded state from the load position through application of a setting force onto the internal portion in a distal direction when the convertible plunger is disposed in the medical barrel;
g. the operation being application of an actuation force onto the convertible plunger in the distal direction when the convertible plunger is disposed in the medical barrel;
h. the convertible plunger further including a liquid sealing section on a distal end of the convertible plunger, the liquid sealing section having a generally cylindrical exterior surface configured to provide a seal against an inner wall of the medical barrel when the convertible plunger is disposed therein, the liquid sealing section having a film or a cap covering a product-facing surface and a sidewall of the liquid sealing section.

US Pat. No. 10,765,810

DRIVE ASSEMBLY AND SPACER FOR DRUG DELIVERY SYSTEM

Becton, Dickinson and Com...

1. A drug delivery system for injecting a medicament, the system comprising:a housing having a proximal end and a distal end;
a container configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure;
a needle in fluid communication with the container;
a spacer configured to be engaged with the stopper;
a first plunger;
a first spring configured to bias the first plunger in an axial direction relative to the container;
a second plunger disposed about the first plunger; and
a second spring configured to bias the second plunger in the axial direction,
wherein the first plunger is configured to move the spacer and the container relative to the housing in the axial direction via the first spring,
wherein the second plunger is configured to move the spacer and the stopper relative to the container in the axial direction via the second spring, and
wherein the spacer comprises a body and a flange extending radially outward from the body, the body of the spacer configured to engage the first plunger, the flange of the spacer configured to engage the second plunger.

US Pat. No. 10,765,809

AUTO-INJECTOR FOR EPINEPHRINE INJECTION

MERCK PATENT GMBH, Darms...

1. A reloadable auto injector comprising:a needle insertion driver having a first spring and an injection driver having a second spring within a housing, wherein the reloadable auto injector is configured to perform a first injection sequence when pressed against a skin of a patient, the first injection sequence comprising the needle insertion driver being configured to drive a syringe having a needle in a distal direction and the injection driver being configured to drive a syringe stopper in the distal direction to a first stopper position to eject a first fluid portion through the needle,
wherein the reloadable auto injector is configured to perform a second injection sequence when pressed against the skin of the patient, wherein the needle insertion driver is configured to be re-activated upon reloading of the auto injector within the housing, and wherein the reloadable auto injector is configured to perform the second injection sequence after reloading,
the second injection sequence comprising the needle insertion driver being configured to drive the syringe having the needle in the distal direction and the injection driver being configured to drive the syringe stopper in the distal direction from the first stopper position to a second stopper position to eject a second fluid portion through the needle,
wherein the reloadable auto injector is configured to retract the syringe and the injection driver within the housing during reloading.

US Pat. No. 10,765,808

DRUG DELIVERY DEVICE INCLUDING MOTION DETECTION SYSTEM

Sanofi-Aventis Deutschlan...

1. A drug delivery device comprising:a motor configured to advance a stopper in a cartridge of medicament, the motor comprising a rotatable output shaft and a pinion attached to the output shaft;
a cartridge retainer configured to receive the cartridge of medicament, the cartridge retainer moveable between an open position and a closed position;
a controller;
a motion detection system configured to provide positional feedback to the controller, wherein the motion detection system comprises an optical encoder and at least one element operatively coupled to the pinion of the motor and configured to rotate with the pinion such that the at least one element passes through the optical encoder; and
one or more switches configured to detect or confirm whether the cartridge retainer has been properly closed.

US Pat. No. 10,765,807

FLUID DELIVERY DEVICE WITH SENSOR

INSULET CORPORATION, Act...

1. A method for controlling a pump system, the pump system having a housing and a monitoring component including circuitry, the method comprising:receiving by the monitoring component a first signal from a pressure sensor indicative of a first pressure at a start of a delivery operation for a liquid drug;
determining by the monitoring component the first pressure at the start of the delivery operation for the liquid drug based on the received first signal;
receiving a second signal from the pressure sensor indicative of a second pressure at an end of the delivery operation for the liquid;
determining, by the monitoring component the second pressure at the end of the delivery operation for the liquid drug based on the received second signal;
determining, by the monitoring component a fluid capacitance value of a fluid path used for the delivery operation of the liquid drug;
determining an intended liquid drug delivery amount;
determining a delivery error amount of the liquid drug based on the first and second pressures, the fluid capacitance value, and the intended liquid drug delivery amount; and
in response to the determined delivery error amount, the monitoring component actuates an alarm actuator by outputting an alert-alarm signal to the alarm actuator, the alarm actuator configured to actuate an alarm.

US Pat. No. 10,765,806

MEDICATION MECHANISM

NITTO DENKO CORPORATION, ...

1. A dosing mechanism for dosing a patient with liquid medicine filled in a medicine vessel, comprising: a body; and a disposable portion that is removably attached to the body,wherein the disposable portion comprises:
a pump that sucks the medicine from the medicine vessel and discharges the medicine to the patient;
a suction-side tube that extends from the pump toward the medicine vessel;
a discharge-side tube that extends from the pump toward the patient; and
a connector that is located at a front end of at least one of the suction-side tube and the discharge-side tube, so as to be capable of being connected to a tube extending from the medicine vessel or the patient,
wherein the body comprises a sensor in a position corresponding to the suction-side tube or the discharge-side tube attached to the body; and
wherein the dosing mechanism further comprises:
a relief pipe whose one end is connected to the suction-side tube while the other end is connected to the discharge-side tube, and
a valve connected to the relief pipe, the valve comprising a first channel through which the medicine can pass without stopping is formed in parallel with a second channel which can be opened and closed “is amended as” a valve connected to the relief pipe, the valve comprising a first channel through which the medicine can pass without stopping is formed in parallel with a second channel through which the medicine can pass, wherein the second channel can be opened and closed.

US Pat. No. 10,765,805

INFUSION PUMP INCLUDING PAIN CONTROLLED ANALGESIC (“PCA”) APPARATUS

Baxter International Inc....

1. An infusion pump apparatus comprising:a housing;
a pump actuator supported by the housing;
a pain controlled analgesic (“PCA”) input device;
electronics configured to
control the pump actuator,
provide a voltage to the PCA input device, and
sense an electrical signal in response to the PCA input device being depressed; and
a controller electrically coupled to the electronics and programmed to (i) determine whether the sensed electrical signal is discontinuous, and (ii) if the sensed electrical signal is discontinuous, transmit an output indicative of the PCA input device functioning improperly.

US Pat. No. 10,765,804

INJECTION DEVICE FOR ENDOSCOPY

NATIONAL CANCER CENTER, ...

1. An endoscopic injection apparatus comprising:a needle configured to eject an injection solution;
a pair of holding forceps which surrounds the needle;
an operation unit configured to hold an injection targeted area using the pair of holding forceps and injects the injection solution when the needle is inserted in a tissue;
a sensor configured to sense a spread angle of the pair of holding forceps; and
a notification unit configured to display a sensing result of the sensor,
wherein the operation unit comprises:
a body with a needle operation button on one end;
an injection hole for the injection solution which is formed on the body; and
a forceps operation unit configured to operate the pair of holding forceps according to a sliding movement and surround a body exterior,
wherein the needle operation button is configured to operate only when the spread angle of the pair of holding forceps is within a predetermined angle, wherein the predetermined angle is selected to be a state in which the pair of holding forceps are holding the injection targeted area,
wherein the endoscopic injection apparatus further comprises:
a predetermined length of a shaft which is connected with another end of the body and wherein a fixing piece is formed within an inner one end of the shaft and a part of the fixing piece protrudes outside the shaft and the pair of holding forceps is installed in hinged to the fixing piece with an incision unit formed in the middle of the fixing piece; and
a fixing member configured to fix the needle which is formed with a predetermined length and diameter as to be inserted and installed in the shaft,
wherein the fixing member has at least one side that is formed in a concave shape in a needle direction and a predetermined space is formed between the at least one side of the fixing member and an inner side of the shaft.

US Pat. No. 10,765,802

SYSTEM AND METHOD FOR INSULIN PUMP MEDICAL DEVICE INCLUDING A SLIDER ASSEMBLY WHEREIN IMAGES ON DISPLAY ALLOW FOR HIGHLIGHTING AND MAGNIFYING IMAGES

DEKA PRODUCTS LIMITED PAR...

1. A medical system comprising:a first medical device comprising:
a pump assembly configured to pump fluid out of a reservoir for delivery;
a feedback system configured to indicate the dosage of fluid delivered;
a display assembly for rendering information; and
an input assembly comprising at least one slider assembly, for manipulating the information rendered on the display assembly and for providing an input signal in response to an input; and
a second medical device configured to communicate with the first medical device, the second medical device comprising:
telemetry circuitry for communication with the first medical device;
a display assembly for rendering information;
an input assembly comprising at least one slider assembly for manipulating the information rendered on the display assembly and for providing an input signal in response to an input;
a computer program product residing on a computer readable medium having a plurality of instructions stored thereon which, when executed by a processor, cause the processor to perform operations comprising:
selecting information on the display assembly,
highlighting the selected information on the display assembly,
magnifying the highlighted selected information with respect to the nonhighlighted information on the display assembly.

US Pat. No. 10,765,801

DRUG DELIVERY DEVICE WITH PROXIMITY SENSOR

AMGEN INC., Thousand Oak...

1. An on-body injector comprising:a reservoir including a bore having a first end and a second end, and a plunger assembly including a plunger moveable within the bore between the first and second ends;
a cannula having an operational state wherein the cannula is connected in fluid communication with the reservoir;
a drive coupled to the plunger assembly to move the plunger between the first and second ends for moving a drug product out of the reservoir and through the cannula;
a housing, wherein the reservoir, the cannula, and the drive are disposed at least partially within the housing;
a proximity sensor operably coupled to move relative to the housing, the proximity sensor having a first sensor state wherein the proximity sensor extends from the housing and a second sensor state wherein the proximity sensor is retracted toward the housing relative to the first sensor state;
a biasing member configured to bias the proximity sensor toward the first sensor state; and
a lock operably coupled to the proximity sensor, the lock having a first position resisting movement of the plunger between the first and second ends of the reservoir when the proximity sensor is in the first sensor state and the lock having a second position permitting movement of the plunger between the first and second ends of the reservoir when the proximity sensor is in the second sensor state.

US Pat. No. 10,765,800

PUMP ASSEMBLY WITH A REMOVABLE COVER ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

1. An infusion pump assembly comprising:an enclosure;
a pump positioned at least partially within the enclosure and configured to effectuate the dispensing of infusible fluid;
a processor positioned at least partially within the enclosure and operatively coupled to an input system, the processor configured to receive an input signal from the input system and to control the pump; and
a removable cover configured to releasably engage the enclosure;
wherein a combination of the removable cover and at least a portion of the enclosure define a power supply cavity, the combination preventing a removable power supply within the power supply cavity from being reverse-polarity electrically coupled to the processor.

US Pat. No. 10,765,799

FAIL-SAFE DRUG INFUSION THERAPY SYSTEM

ICU Medical, Inc., San C...

1. An infusion pump system comprising:a user interface device comprising a display and a first hardware processor; and
a pump device comprising a motor and a second hardware processor;
wherein the first hardware processor is configured to:
transmit infusion parameters to the pump device over a communication link, wherein the second hardware processor is configured to control the motor for delivery of infusion fluid based on the infusion parameters;
detect a first status of the pump device;
determine that the pump device is in an inoperative state based on the detected first status;
command the pump device to reboot; and
update the pump device after it is rebooted,
wherein the second hardware processor is configured to determine a time that the second hardware processor is able to operate independently of the first processor and display the time on the display of the user interface device.

US Pat. No. 10,765,798

FEEDING SYRINGE HOLDER

Medline Industries, Inc.,...

1. A holder for a syringe body of a formulated food solution delivery system, the holder comprising:a handle configured to be hung on a support;
a body connected to the handle and having a central opening for receiving a barrel of the syringe body, the body having an upper, collar-receiving region and a lower region each having a transverse cross-sectional area, the transverse cross-sectional area of the upper region having a frustoconical wall portion and being larger than the transverse cross-sectional area of the lower region, the lower region having an annular wall portion for extending around the syringe body barrel, the body configured to keep the syringe body upright with the handle hung on the support; and
at least one alignment portion of the body configured to engage at least one protrusion of the syringe body and resist turning of the syringe body in the central opening of the body, wherein the at least one alignment portion of the body includes at least one opening having a first portion in the frustoconical wall portion and a second portion in the annular wall portion.

US Pat. No. 10,765,797

DEVICE FOR CONTROLLING FLUID DELIVERY

1. A device for controlling delivery of a fluid to a patient comprising:an injector device having a cylindrical body having a front end having an opening through which fluid may flow into or out of the cylindrical body and a back end having an opening, and a connector device at the front end; and
a plunger having a head having an opening and the plunger further having a valve cap, the valve cap capable of opening and closing the opening in the head, the plunger for insertion into the cylindrical body of the injector device, the plunger further having a partial hollow interior having a back end, a spring having a first spring end and a second spring end, the first spring end connected to the back end of the partial hollow interior and the second end connected to the valve cap adjacent to the opening in the head, the partial hollow interior for capturing fluid when the spring moves the valve cap away from the opening in the head.

US Pat. No. 10,765,796

TRANS ANAL IRRIGATION PLATFORM WITH BED MODULE

Hollister Incorporated, ...

1. A trans anal irrigation system, comprising:a rectal catheter, the rectal catheter having a barrel with an insertion tip at a proximal end thereof, the barrel defining at least one lumen therein and at least one port communicating with the at least one lumen and an exterior of the barrel;
a seat having a receptacle for releasably receiving a distal end of the barrel therein;
a valve formed in the seat, the valve being in fluid communication with the at least one lumen of the barrel when the barrel is in the seat and selectably movable between open and closed positions which permit and prevent, respectively, fluid flow out of the at least one lumen at the distal end of the barrel;
a connector adjoins a side of the seat at a 90° angle relative to a longitudinal axis of the barrel, the connector having a passage in fluid communication with the at least one lumen; and
an irrigation fluid reservoir and fluid supply tubing in fluid communication with the irrigation fluid reservoir and the connector.

US Pat. No. 10,765,795

METHOD AND APPARATUS FOR THE DIALYSIS OF BLOOD

Medical Components, Inc.,...

1. A tunneling tool, comprising:a shaft comprising a proximal end and a distal end, the shaft configured to advance a catheter under a skin of a patient;
a plurality of fingers extending from the shaft at or near the proximal end;
a sleeve slidably disposed on the shaft,
wherein each finger of the tunneling tool is configured to be received within at least one slot of a catheter, the catheter comprising an elongated body, a plurality of lumens, and the at least one slot formed in an outer wall at an end of the elongated body and communicating with a corresponding one of the lumens; and
sliding the sleeve over the plurality of fingers causes the plurality of fingers to grip the end of the elongated body of the catheter.

US Pat. No. 10,765,794

METHOD AND APPARATUS FOR THE DIALYSIS OF BLOOD

Medical Components, Inc.,...

1. A catheter, comprising:a body comprising a body side wall, a body proximal end, and a body distal end;
a first lumen extending from the body proximal end to the body distal end, the first lumen forming a first mouth at the body distal end, the first lumen comprising:
a first slot formed in a portion of the body side wall and in fluid communication with the first lumen, the first slot comprising a first slot proximal end and a first slot distal end, the first slot configured such that fluid being discharged from the first lumen primarily exits at and/or near the first slot distal end and fluid being drawn into the first lumen primarily enters at and/or near the first slot proximal end;
a second lumen extending from the body proximal end to the body distal end, the second lumen forming a second mouth at the body distal end, the second lumen comprising:
a second slot formed in a portion of the body side wall and in fluid communication with the second lumen, the second slot comprising a second slot proximal end and a second slot distal end, the second slot configured such that fluid being discharged from the second lumen primarily exits at and/or near the second slot distal end and fluid being drawn into the second lumen primarily enters at and/or near the second slot proximal end;
wherein the first slot is located on the first lumen at a first slot position and the second slot is located on the second lumen at a second slot position, the first slot position being diametrically opposite to the second slot position.

US Pat. No. 10,765,793

AMMONIA DETECTION IN DIALYSIS SYSTEMS

Fresenius Medical Care Ho...

1. A spectroscopic detection system, comprising:a sensor configured to reflect light of a first wavelength associated with a presence of a reference substance on the sensor and configured to reflect light of a second wavelength associated with a presence of a monitored substance on the sensor, the monitored substance flowing to the sensor from a circulating fluid;
a detector comprising first and second channels for respectively receiving the light of the first and second wavelengths reflected from the sensor; and
one or more processors in electrical communication with the detector and configured to identify an excess condition of the monitored substance with respect to the circulating fluid based on a ratio of a second amount of the light of the second wavelength received at the detector to a first amount of the light of the first wavelength received at the detector.

US Pat. No. 10,765,792

SYSTEM AND METHOD FOR DIALYZER EVALUATION

Fresenius Medical Care Ho...

1. A dialyzer analysis system, comprising:a first sensor connected to a first portion of a blood flow path disposed on an input side of a dialyzer, wherein the first sensor is configured to obtain a measurement corresponding to hematocrit of blood in the first portion of the blood flow path;
a second sensor connected to a second portion of the blood flow path disposed on an output side of the dialyzer, wherein the second sensor is configured to obtain a measurement corresponding to hematocrit of blood in the second portion of the blood flow path; and
a controller configured to determine a red blood cell volume loss corresponding to an amount of red blood cells remaining in the dialyzer based on the measurements from the first and second sensors.

US Pat. No. 10,765,790

DETECTION OF PUMP THROMBOSIS

Medtronic, Inc., Minneap...

41. A non-transitory computer-readable storage medium comprising instructions that, when executed by processing circuitry of a medical device system, cause the processing circuitry to:receive, by the processing circuitry communicatively coupled to a transducer, a signal representative of a mechanical wave generated by a mechanical circulatory support device;
identify a first portion of the signal representative of at least one harmonic of the mechanical wave;
normalize, based on a second portion of the signal, the first portion;
determine, based on the normalized first portion, an indication of pump thrombosis based on the signal; and
based on the indication of the pump thrombosis, at least one of alert, by a user interface communicatively coupled to the processing circuitry, a user of the indication of pump thrombosis or initiate an intervention.

US Pat. No. 10,765,787

COMPACT SOUND SUPPRESSING MUFFLER FOR BREAST VACUUM PUMPS

DAO Health, El Dorado Hi...

1. A sound suppression system for reducing or eliminating sound produced by the operation of a breast vacuum pump, comprising:a. a sound suppressing muffler assembly having an air entry port, said air entry port adapted to communicate with an air outlet port of said breast vacuum pump;
b. said sound suppressing muffler assembly including a muffler housing defining an internal space communicating with said air entry port;
c. said muffler assembly having an opening to atmosphere;
d. at least one non-linear, reciprocal tortuous air path in said muffler assembly;
e. said non-linear, reciprocal tortuous air path creating an indirect flow of air through said non-linear, reciprocal tortuous air path to atmosphere, said indirect air flow suppressing noise energy produced by air moving through said non-linear, reciprocal tortuous air path; and
said non-linear, reciprocal tortuous air path comprising at least one sound-absorbing porous foam structure disposed in said at least one non-linear, reciprocal tortuous air path, said at least one sound absorbing porous foam structure absorbing sound energy from said air as said air moves through said non-linear, reciprocal tortuous air path toward said opening in said muffler housing.

US Pat. No. 10,765,786

SYSTEM AND METHOD FOR MULTIPLE DIRECTION FLEXIBLE INLINE CANISTER

KCI Licensing, Inc., San...

1. A method of manufacturing an inline storage pouch, the method comprising:forming a pouch with a first chamber and a second chamber;
disposing an absorbent material within the first chamber;
disposing a manifold within the second chamber;
coupling a first port to the pouch, the first port being configured to fluidly couple the first chamber to a dressing for receiving fluids;
coupling a second port to the pouch, the second port being configured to fluidly couple the second chamber to a therapy unit for supplying reduced pressure; and
disposing a plurality of air bridges between the first chamber and the second chamber to provide fluid communication between the first chamber and the second chamber.

US Pat. No. 10,765,785

WOUND CARE AND INFUSION METHOD AND SYSTEM UTILIZING A THERAPEUTIC AGENT

ThermoTek, Inc., Flower ...

1. A method of treating a wound area, the method comprising:covering a wound with a dressing;
coupling the dressing to an oxygen source via a first tube having a first disconnect;
coupling the dressing to a vacuum pump via a second tube having a second disconnect;
administering to the wound at least one of a first treatment modality and a second treatment modality;
wherein the first treatment modality comprises:
supplying oxygen from the oxygen source to a humidifier coupled to the first tube between the dressing and the first disconnect;
utilizing the humidifier to increase a relative humidity of the oxygen above an ambient relative humidity;
delivering, via the first tube, the humidified oxygen to the wound via a tube associated with the dressing; and
wherein the second treatment modality comprises:
opening a pump solenoid and a patch solenoid disposed between the vacuum pump and a bottle;
applying via the vacuum pump and the second tube, negative pressure to the dressing;
collecting, in the bottle coupled to the second tube between the dressing and the second disconnect, exudate from the wound;
wherein administration of the first treatment modality and the second treatment modality overlap in time; and
wherein closing an oxygen solenoid and the patch solenoid isolates the dressing and facilitates pressure testing of the dressing.

US Pat. No. 10,765,784

CONTAINER FOR DRAINAGE OF FLUIDS OR WOUND SECRETION

PFM MEDICAL AG, Cologne ...

1. A container for drainage of fluid and/or wound secretion, comprising:an inlet opening to connect with a drainage line, and
an outlet opening to release waste air accumulated inside the container during drainage,
wherein the container is pre-evacuated, and is rigid as not to change form when pre-evacuated,
wherein the outlet opening is sealable, such that the container is transferable in a first operating condition and in a second operating condition,
wherein, in the first operating condition, the outlet opening is sealed, such that a suction is achievable at the inlet opening by a vacuum inside the container, and
wherein, in the second operating condition, the outlet opening is opened, such that air is enterable into the container through the outlet opening which neutralizes the vacuum inside the container, whereby drainage of fluid and/or wound secretion is startable according to a vacuum drainage and afterwards is continuable as gravity drainage,
wherein the outlet opening comprises a first tubular element, which is at least one of clampable or pinchable to seal the outlet opening,
wherein the outlet opening comprises a filter, which is configured to provide a vent which is operable for at least one of air to release from the container or for air to enter into the container,
wherein the filter is gas permeable and liquid impermeable; and
wherein the container is pre-evacuated in a range of 40,000 Pascal to 98,000 Pascal.

US Pat. No. 10,765,783

DRESSINGS AND METHODS FOR TREATING A TISSUE SITE ON A PATIENT

KCI Licensing, Inc., San...

1. A dressing for treating a tissue site, the dressing comprising:a covering configured to be positioned over the tissue site to create a sealed space, the covering comprising:
a film having a periphery and a center, an adhesive disposed on the periphery of the film, and the center of the film being free of the adhesive and configured to permit evaporation of water vapor through the center: a manifold configured to be positioned over the covering; and a drape configured to be positioned over the manifold and further configured to have a first aperture configured to be fluidly coupled to a forced-air device, and at least one second aperture configured to be fluidly coupled to an ambient environment to generate a fluid flow between the first aperture and the at least one second aperture in response to operation of the forced-air device.

US Pat. No. 10,765,782

HEMOSTATIC DEVICES AND METHODS OF USE

MEDTRONIC, INC., Minneap...

1. An anchorage device configured to surround an implantable medical device, the anchorage device comprising:a substrate comprising a first piece and a second piece that is joined with the first piece, the first piece being made entirely of a hemostatic agent and the second piece comprising an active pharmaceutical ingredient,
wherein the hemostatic agent is tranexamic acid.

US Pat. No. 10,765,780

METHOD OF PRODUCING TISSUE REGENERATION SUBSTRATE

GUNZE, LIMITED, Kyoto (J...

1. A method of producing a tissue regeneration substrate comprising:preparing a layer containing a nonwoven fabric having an average pore size of 20 to 50 ?m;
discharging threads made of a bioabsorbable material on the layer containing a nonwoven fabric having an average pore size of 20 to 50 ?m by melt blowing to form a layer containing a nonwoven fabric having an average pore size of 5 to 18 ?m to produce a stack; and
needle-punching the stack to integrate the layer containing a nonwoven fabric having an average pore size of 20 to 50 ?m and the layer containing a nonwoven fabric having an average pore size of 5 to 18 ?m.

US Pat. No. 10,765,778

BIO-RESORBABLE RETICULAR PROSTHESIS AND RELATED MANUFACTURING METHOD

1. A prosthesis (1, 1?) for organs with lumens, which prosthesis comprises:at least one bio-absorbable material layer (2), configured to be arranged in contact with said lumen organ when said prosthesis (1, 1?) is implanted,
at least one auxetic material layer (3), arranged in contact with and within said at least one bio-absorbable material layer (2), and
a reinforcing layer, said reinforcing layer being coated by said auxetic material layer (3),wherein said prosthesis (1?) being usable as an endovascular prosthesis, which prosthesis is a stent:wherein said bio-absorbable material layer (2) is a mesh having a plurality of polygonally-shaped cells,wherein said bio-absorbable material layer (2) comprises polydioxanone (PDS),wherein said auxetic material layer (3) comprises a plurality of side longitudinal strips (31), arranged in parallel having an auxetic behavior in the longitudinal development direction,wherein said auxetic material layer (3) comprises expanded polytetrafluoroethylene (Goretex®), andwherein said reinforcing layer is made of metal.

US Pat. No. 10,765,777

LIGHT ADJUSTABLE INTRAOCULAR LENSES USING UPCONVERTING CORE-SHELL NANOPARTICLES AND NEAR INFRARED (NIR) LIGHT

California Institute of T...

1. A light adjustable intraocular lens comprising:(a) a photopolymerizable prepolymer;
(b) a UV-Vis photoinitiator;
(c) at least one upconverting core-shell nanocrystal; and
(d) optionally a UV-Vis blocker;
wherein the light adjustable intraocular lens further optionally comprises a polymer matrix in which the photopolymerizable prepolymer material, the UV-Vis photoinitiator, the optional UV-Vis blocker, and the at least one upconverting core-shell nanocrystal are distributed.

US Pat. No. 10,765,773

DECORATIVE SPLINT OR CAST MATERIAL

Bella Bling, LLC, Chelms...

1. A method of manufacturing a decorative splint material, the method comprising:providing one or more layers of fiberglass fabric impregnated with a moisture-curable polyurethane resin;
adding a substrate to the layers of fiberglass fabric, the substrate holding a plurality of discrete three-dimensional decorative elements;
overlaying the substrate with a flexible material having a plurality of openings, wherein the openings align with the three-dimensional decorative elements such that at least a portion of the decorative elements are exposed through the openings.

US Pat. No. 10,765,772

NATURAL METHOD OF REDUCTION AND REMOVAL OF PATHOGENIC AGENTS AND MICROORGANISMS CONTAINED IN SOLIDS

1. A method for the reduction and/or removal of pathogenic agents and microorganisms contained in solids, comprising the following steps:a) providing a front chamber for the entrance of the starting material; a contiguous rear chamber associated with the entrance chamber, by means of which the processed material is expelled; said contiguous rear chamber containing a grinding means that rotates when it is actuated by an engine; and a piston that enters into the front chamber running along said chamber into the rear chamber until it reaches a grinding means, where the grinding means consists of a solid, hard and heavy cylinder associated with a transverse axis, said cylinder being provided with a set of longitudinal slots from base to base that form edges with the cylinder surface, where the light existing between the solid cylinder and the drum containing it is smaller than 5 mm,
b) Purification of the starting material to dispose of materials that combine a size over 10 cm3 and hardness similar to boulder or paving stone and malleability as metal,
c) Adjustment of the humidity degree of the material obtained in step b),
d) Grinding and heating and pressurizing simultaneously the material obtained in step c),
where the grinding and heating and pressurizing of step d) are carried out simultaneously by grinding the material until the material is powdered; and by means of friction of the powdered material between the light existing between the solid cylinder rotating and the drum containing it, plus the pressure of the piston advancing towards the grinding cylinder, heating and pressurizing is obtained, thus converting water into steam until the desired temperature is reached.

US Pat. No. 10,765,771

AROMATHERAPY LAMP WITH MULTIPLE FUNCTIONS

Dong Duan Jia Sheng Light...

1. A lamp comprising:a lamp body;
an acoustics mounted in the lamp body;
a light source device mounted in the lamp body; and
a humidifying device mounted in the lamp body;
wherein:
the lamp body includes a base, a mounting seat mounted on the base, and a lampshade mounted on the mounting seat;
the base has an interior provided with a water storage chamber;
the base is provided with a water level window aligning with the water storage chamber;
the base is further provided with a water entrance connected to the water storage chamber;
the mounting seat is provided with a water passage connected to the water storage chamber;
the acoustics is mounted in the base;
the light source device is mounted on the mounting seat;
the humidifying device is mounted on the mounting seat;
the humidifying device includes a humidifier mounted on the mounting seat, and a water drawing stick mounted in and extending through the mounting seat; and
the water drawing stick has a lower end extending into the water storage chamber of the base, and an upper end connected to the humidifier.

US Pat. No. 10,765,770

HALOGENATED HETEROCYCLIC N-HALAMINE COATED GARBAGE BAGS

THE GLAD PRODUCTS COMPANY...

1. A garbage bag having walls which are comprised of polyethylene, wherein said walls of the garbage bag are coated with particles of a halogenated heterocyclic N-halamine having a particle size which is within the range of about 0.01 ?m to 20 ?m, and wherein the particles of the halogenated heterocyclic N-halamine are present only on the surface of the walls of the garbage bag; and wherein the walls of said garbage bag have a wall thickness which is within the range of 0.0002 inch to 0.005 inch thick.

US Pat. No. 10,765,768

OPTICAL FIBER BASED ANTIMICROBIAL ULTRAVIOLET RADIATION THERAPY SYSTEM

TELEFLEX MEDICAL INCORPOR...

1. An ultraviolet irradiation system comprising:a medical device having a central lumen with an inner wall;
an optical fiber disposed in the medical device, the optical fiber having a longitudinal length and a cladding layer extending along the longitudinal length, the cladding layer having a varied thickness over the longitudinal length;
and an ultraviolet wave generator, wherein ultraviolet waves generated by the wave generator are dispersed along the longitudinal length of the optical fiber to disinfect the central lumen of the medical device, and wherein the ultraviolet waves are uniformly emitted along the longitudinal length of the optical fiber to uniformly irradiate the inner wall of the central lumen.

US Pat. No. 10,765,767

DISINFECTING METHODS AND APPARATUS

Inikoa Medical, Inc., Ne...

1. An apparatus for bacterially disinfecting a flat surface and a plurality of curved surfaces of different shapes, the apparatus comprising:a flexible body made of a material that is transparent to light and having formed therein a channel, the flexible body having an ability to transition from a flat configuration to a plurality of curved configurations to respectively bacterially disinfect the flat surface and the plurality of curved surfaces; and
a radially emitting fiber having a length and being disposed in the channel, the radially emitting fiber having a longitudinal axis and configured to radially emit bacterial disinfecting light, at least a portion of the radially emitting fiber having an axial and/or radial freedom of movement inside the channel when the flexible body transitions from the flat configuration to one or more of the plurality of curved configurations, the axial and/or radial freedom of movement reducing the amount of tensile stress applied along the length of the radially emitting fiber when the flexible body transitions from the flat configuration to the one or more plurality of curved configurations as compared to an amount of tensile stress that would otherwise be applied to the radially emitting fiber in an absence of the axial and/or radial freedom of movement of the radially emitting fiber inside the channel, the radially emitting fiber having a proximal end and a distal end and the channel has an end wall, the distal end of the radially emitting fiber being spaced a distance from the end wall of the channel, the proximal end of the radially emitting fiber being fixed relative to the flexible body and the distal end of the radially emitting fiber is not fixed to the flexible body.

US Pat. No. 10,765,766

METHODS AND APPARATUS FOR TREATMENT OF LUER CONNECTORS

CatheCare LLC, New York,...

1. A method of sterilizing at least one luer connector comprising:providing a luer connector treatment device comprising a first housing component and a second housing component, the second housing component having a treatment chamber including at least two luer connectors, wherein the first housing component is reversibly coupled to the second housing component, wherein at least one of the first housing component and second housing component has at least one source of UV radiation;
engaging a first medical device with one of the at least two luer connectors;
uncoupling at least a portion of the first housing component from the second housing component;
engaging a second medical device with at least one remaining luer connector of the at least two luer connectors to form a fluidic channel between the first medical device and the second medical device;
disengaging the second medical device from the at least one remaining luer connector of the at least two luer connectors;
coupling the uncoupled portion of the first housing component with the second housing component; and
sterilizing the treatment chamber by applying UV radiation to the treatment chamber by way of the at least one source of UV radiation.

US Pat. No. 10,765,765

SINGLE-EMITTER LIGHTING DEVICE THAT OUTPUTS A MINIMUM AMOUNT OF POWER TO PRODUCE INTEGRATED RADIANCE VALUES SUFFICIENT FOR DEACTIVATING PATHOGENS

KENALL MANUFACTURING COMP...

1. A method of deactivating MRSA bacteria in a volumetric space over a period of time, the method comprising:providing light from at least one lighting element of each of one or more lighting fixtures installed in the volumetric space, wherein the light provided by the at least one lighting element is produced from a single light source, wherein at least a first component of the light is a disinfecting light having a wavelength of about 405 nm and has a minimum integrated irradiance of 0.01 mW/cm2, and wherein at least a second component of the light has a wavelength of greater than 420 nm;
receiving first data associated with a desired illuminance level for the volumetric space and second data indicative of desired correlated color temperature for the volumetric space;
determining, based on the first and second data, an arrangement of the one or more lighting fixtures in the volumetric space; and
determining, based on the second data and the volumetric space, a total radiometric power to be applied via the one or more lighting fixtures to produce a desired power density measured at any exposed surface within the volumetric space during the period of time, the desired power density comprising the minimum integrated irradiance of the disinfecting light equal to 0.01 mW/cm2.

US Pat. No. 10,765,763

RADIOLIGANDS FOR MYELIN

CASE WESTERN RESERVE UNIV...

1. A method of detecting myelin in vivo in a subject's tissue, the method comprising:(i) administering to the subject a radioligand including a compound having the formula:

R2 is H, or NHR?, where R? is a lower alkyl group;
R3 is a radiolabeled lower alkyl group, alkylene group, alkenyl group, alkynyl group, or alkoxy group;
wherein R3 includes a radiolabeled group having a radiolabel selected from the group consisting of 18F, 123I, 125I, and 99mTc; or a pharmaceutically acceptable salt thereof; and
(ii) detecting the location, distribution, and/or amount of the radioligand that is bound to and/or labels myelin to detect myelin in the tissue.

US Pat. No. 10,765,760

EXON SKIPPING OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY

Sarepta Therapeutics, Inc...

1. An antisense oligomer conjugate of Formula (IV):
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,765,756

CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY

Purdue Research Foundatio...

1. A conjugate of the formulaB-L-DwhereinB is a targeting ligand of Formula I

L is a bivalent or polyvalent linker; and
D is an optical dye; or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,765,751

PH SENSITIVE CARRIER AND PREPARATION METHOD THEREOF, AND PH SENSITIVE DRUG AND PH SENSITIVE DRUG COMPOSITION EACH CONTAINING THE CARRIER, AND METHOD FOR TREATING OR PREVENTING DISEASES USING THE SAME

TERUMO KABUSHIKI KAISHA, ...

1. A method for treating tumor or inflammation in a patient in need thereof which comprises:administering a pH sensitive drug which comprises a pH sensitive carrier which comprises at least one amphipathic substance, and a physiologically active substance supported in the pH sensitive carrier to induce the pH sensitive carrier to develop a membrane disruptive function and to deliver the physiologically active substance to the site,
said pH sensitive carrier including at least one pH sensitive compound selected from the group consisting of deoxycholic acid, cholic acid, ursodeoxycholic acid, chenodeoxycholic acid, hyodeoxycholic acid, C27 bile acid, glycodeoxycholic acid, glycyrrhizic acid, glycyrrhetinic acid and salts thereof, and said at least one amphipathic substance being at least one selected from the group consisting of a phosphatidylcholine having 10 to 12 carbon atoms, a polyoxyethylene sorbitan monofatty acid ester having 12 to 18 carbon atoms, a sorbitan fatty acid ester having 16 to 18 carbon atoms, glycerol monooleate, glycerol dilaurate, glycerol distearate, glycerol dioleate, polyoxyethylene castor oil and ?-tocopherol, and is capable of developing a membrane disruptive function promoting effect, and
the pH sensitive compound being present in an amount not less than 10 moles per 100 moles of the amphipathic substance.

US Pat. No. 10,765,749

NON-AQUEOUS PATCH

ITOCHU CHEMICAL FRONTIER ...

1. A non-aqueous patch comprising a plaster comprising lidocaine, a dissolving agent, and an elastomer, wherein, the plaster comprises 0.5 to 7 mass % lidocaine and 1.435 to 9.1 mass% dissolving agent, the dissolving agent comprises dipropylene glycol and isostearic acid, and the isostearic acid is present in the plaster in an amount of 1.4 to 2.1 mass%.

US Pat. No. 10,765,744

MAGNETIC PARTICLE CONJUGATES, MICELLES, AND METHODS OF DELIVERING AGENTS

University of Florida Res...

1. A composition comprising: a magnetic particle conjugate having a magnetic particle and a polymer attached to the magnetic particle, wherein the polymer includes an agent (Agent) bonded to the polymer through thermally degradable retro-Diels-Alder-agent group, wherein the polymer comprises:wherein w is 1 to 20, x is 0 to 20, y is 0 to 60, and z is 0 to 10, wherein the polymer is bonded to the magnetic particle on the left of the structure.

US Pat. No. 10,765,736

VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT

Infectious Disease Resear...

1. A pharmaceutical composition comprising a glucopyranosyl lipid adjuvant (GLA) having the formula:
where: R1, R3, R5 and R6 are C11-C20 alkyl; and R2 and R4 are C12-C20 alkyl; or a pharmaceutically acceptable salt thereof; at least one of a surfactant and a biodegradable oil; and a pharmaceutically acceptable carrier, excipient or diluent.

US Pat. No. 10,765,735

ADJUVANT COMPOSITIONS AND METHODS OF USE

EpitoGenesis, Inc., Sacr...

1. An adjuvant comprising:(a) a pharmaceutically acceptable oil selected from the group consisting of wintergreen oil, rosemary oil, mustard seed oil, allyl isothiocyanate, and a mixture thereof;
(b) at least one catechin; and
(c) at least one vitamin selected from the group consisting of vitamin A, vitamin E and vitamin D;
wherein the adjuvant does not comprise an antigen.

US Pat. No. 10,765,715

COMPOSITION CONTAINING SAPONINS OF PANAX GINSENG AS ACTIVE INGREDIENT

KOREAN DRUG CO., LTD., I...

1. A composition containing ginseng saponin as an active ingredient which is useful for extending the lifespan of cells and promoting differentiation of cells, wherein the ginseng saponin is prepared by:exposing the ginseng to steam under a pressure of 1.1 kg/cm2 while removing moisture at 121° C. for 10 minutes using an automatic temperature and humidity control device with a porous shelf (step S1);
continuously injecting air into the ginseng subjected to the step S1 and cooling the ginseng to 90° C. or lower (step S2);
repeating the steps S1 and S2 two times (step S3);
cooling the ginseng to room temperature in an automatic temperature control device and pulverizing the ginseng to a particle size of 1 mm or less, after step S3 (step S4);
extracting the saponin by adding 80% ethyl alcohol to the ginseng subjected to the step S4, and concentrating the extracted saponin (step S5);
preparing a suspension by dissolving the concentrated saponin in ethanol and adding sterilized water, after step S5 (step S6);
adding the suspension to and reacting the suspension with a pectinase enzyme solution drop by drop, after step S6 (step S7);
precipitating the solution subjected to the reaction of step S7 by centrifugation (step S8);
dissolving the generated precipitate in ethyl alcohol (step S9);
suspending the dissolved precipitate by adding sterilized physiological saline solution (step (10);
filtering the suspended precipitate (step S11); and
resuspending the precipitate in sterile physiological saline solution (step S12).

US Pat. No. 10,765,702

VAGINAL LAXITY THERAPY UTILIZING CELL-BASED BULKING COMPOSITIONS

Boston Scientific Scimed,...

1. A system for treating vaginal laxity, comprising:an injection system configured to deliver a composition including adipose tissue cells to a vaginal cavity, the injection system including a balloon that includes an inner wall and an outer wall defining a space therebetween to contain the composition, the balloon including a first end portion and a second end portion and a middle portion between the first end portion and the second end portion, each of the first end portion, the middle portion, and the second end portion includes a plurality of openings to deliver the composition to the vaginal cavity, the injection system configured to reduce a size of the vaginal cavity in response to the delivery of the composition into the vaginal cavity,
the injection system including a tube connected to the balloon to supply the space of the balloon with the composition, a portion of the balloon including a hub member connected to a distal end of the tube.

US Pat. No. 10,765,690

TLR4 AGONISTS AND COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CANCER

GlaxoSmithKline Intellect...

1. A method of treating cancer in a human in need thereof comprising administering a composition comprising a TLR4 agonist which is CRX-601, having the formula shown below:
for treating cancer and combined with an anti-cancer agent, wherein the cancer is a solid tumor and selected from the group consisting of (1) primary and secondary metastatic forms of head and neck cancer and (2) carcinoma of the head and neck.

US Pat. No. 10,765,687

METHODS AND COMPOUNDS TO INHIBIT ENVELOPED VIRUS RELEASE

Northwestern University, ...

1. A method of treating an infection by an enveloped virus in a patient, the method consisting of administering to the patient a pharmaceutical composition consisting of a compound of a formula:

US Pat. No. 10,765,681

PURINE COMPOUNDS POSSESSING ANTICANCER ACTIVITY

Academia Sinica, Taipei ...

1. A compound of Formula (I?):or a pharmaceutically acceptable salt thereof,wherein:Z1 is independently Cl, N, O, or S, as valency permits;
h1 is 0, 1, or 2;
R1 is
in which G1 is independently halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —SRA, —NHRB, —N(RB)2, —C(?O)RA, —C(?O)ORA, —OC(?O)RA, —C(?O)NHRB, —C(?O)N(RB)2, —NRBC(?O)RA, —OC(?O)N(RB)2, —NRBC(?O)ORA, —NRBC(?O)N(RB)2, —S(?O)RA, —OS(?O)2RA, —SO2RA, —NRBSO2RA, or —SO2N(RB)2; and m is 1, 2, 3, 4 or 5;wherein when Z1 is S, G1 is hydrogen;
R2 is
in which each instance of G2 is independently halogen, —CN, —NO2, —N3, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —SRA, —NHRB, —N(RB)2, —C(?O)RA, —C(?O)ORA, —OC(?O)RA, —C(?O)NHRB, —C(?O)N(RB)2, —NRBC(?O)RA, —OC(?O)N(RB)2, NRBC(?O)ORA, NRBC(?O)N(RB)2, —S(?O)RA, —OS(?O)2RA, —SO2RA, —NRBSO2RA, or —SO2N(RB)2;R3 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —CN, —ORA, —SRA, —NHRB, —N(RB)2, —C(?O)RA, —C(?O)ORA, —C(?O)NHRB, —C(?O)N(RB)2, —SO2RA, or two instances of R3 are taken together with Z1 to form optionally substituted heterocyclyl;
R4a is —C(?NH)NH(ORA), —C(?N(ORA)NH2, —C(?NH)NHN(RB)2, —C(?NHN(RB)2)NH2, or —C(?NH)N(RB)2;whereinRA is hydrogen or optionally substituted C1-6 alkyl; and
each instance of RB is independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted aryl.

US Pat. No. 10,765,672

PHARMACEUTICAL FORMULATIONS OF A HIF HYDROXYLASE INHIBITOR

FibroGen, Inc., San Fran...

1. A tablet comprising a tablet core and a coating, wherein the tablet core comprises [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, and the coating comprises a photostabilizing agent, wherein the photostabilizing agent:i) consists essentially of from about 0.1 to about 2 mg/cm2 titanium dioxide and from about 0.1 to about 0.4 mg/cm2 Allura Red AC or from about 0.1 to about 0.4 mg/cm2 Allura Red AC in aluminum lake; and
optionally at least one additional dye selected from the group consisting of:
from about 0.004 to about 0.4 mg/cm2 iron oxide red;
from about 0.009 to about 0.2 mg/cm2 iron oxide yellow;
from about 0.01 to about 0.03 mg/cm2 Sunset Yellow FCF; and
from about 0.01 to about 0.03 mg/cm2 Sunset Yellow FCF in aluminum lake;wherein the amount of photostabilizing agent is based on surface area of the tablet core; andii) prevents the transmission of light at a wavelength range of between about 200 nm and 550 nm
and further wherein the tablet contains less than about 0.2% w/w photodegradation product of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid relative to the amount of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid.

US Pat. No. 10,765,669

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DYRK-RELATED DISEASES, CONTAINING PYRIDINE-BASED COMPOUND AS ACTIVE INGREDIENT

KOREA RESEARCH INSTITUTE ...

1. A method for treating or improving DYRK-related diseases in a subject in need thereof comprising:a compound or a pharmaceutically acceptable salt thereof represented by formula 1 below as an active ingredient:

(in formula 1 above,
R1 is a hydrogen or —NR6R7, wherein R6 and R7 are each independently a hydrogen, a C1-C5 straight or branched chain alkyl or benzyl;
R2, R3 and R4 are each independently a hydrogen, a halogen, a C1-C5 straight or branched chain alkyl, —NR8R9, OR8, —CN, —NHC(O)R8, —SO2R8, —OS(O)2R8, pyrrolidine, piperidine, or morpholin, wherein R8 and R9 are each independently a hydrogen, a C1-C5 straight or branched chain alkyl, a C1-C5 straight or branched chain alkynyl, a C6-C12 straight or branched chain alkenyl, a C6-C12 aryl, a C6-C12 aryl substituted with a halogen, or a C6-C12 aryl substituted with a trihalogen methyl; and
R5 is a hydrogen, a C1-C5 straight or branched chain alkyl, unsubstituted 4-piperidine, acetyl-substituted 4-piperidin;
wherein the DYRK-related disease is at least one disease selected from the group consisting of Down syndrome, degenerative brain diseases and metabolic diseases.

US Pat. No. 10,765,668

ORAL TABLET COMPOSITION COMPRISING DEXLANSOPRAZOLE, ORAL TABLET COMPRISING THE SAME AND METHOD FOR MANUFACTURING THE SAME

LOTTE FINE CHEMICAL CO., ...

1. An oral tablet composition comprising:0:1 to 20 wt % amorphous dexlansoprazole,
20 to 50 wt % mannitol having an average particle size of 100 to 400 m,
25 to 55 wt % disintegrating agent selected from one or more of the group consisting of low-substituted hydroxypropyl cellulose, croscarmellose sodium, sodium starch glycolate, carboxymethyl cellulose sodium, carboxymethyl cellulose calcium, and crospovidone, and
0.5 to 5 wt % lubricant,
wherein a friability of the oral tablet is 0.01 to 0.5%.

US Pat. No. 10,765,662

MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS

Janssen Pharmaceuticals, ...

1. A compound of formula (I)
or a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof consisting of a mono- or di-substituted indole group; wherein:
R1 is H, R2 is F, Cl or OCH3 and R3 is H;
R1 is H, R2 is F or Cl and R3 is CH3;
R1 is CH3, R2 is OCH3 and R3 is H;
R1 is F, R2 is F and R3 is H;
R1 is CH3, R2 is F and R3 is H;
R1 is CF3 or OCF3 and R2 is H and R3 is H;
R1 is OCF3, R2 is OCH3 and R3 is H; or
R1 is OCF3, R2 is H or R3 is CH3.

US Pat. No. 10,765,660

AGENT CONTAINING FLAVONOID DERIVATIVES FOR TREATING CANCER AND INFLAMMATION

1. A method of treating a cancer selected from a group consisting of: breast cancer, brain cancer, Kaposi sarcoma, leukemia, lung cancer, melanoma, ovarian cancer, colon cancer, renal cancer, pancreatic cancer, and prostate cancer, the method comprising the steps of:administering a pharmaceutical composition comprising a compound having the general chemical structure of chemical formula 4:
or any pharmaceutically acceptable salt thereof;wherein the group R1 is an alkoxy group the groups R2 and R3 are each a methoxy group or a hydroxy group, the group R6 is an alkoxy group, a hydroxyl group or hydrogen, the group R8 is an alkoxy group or hydrogen, the group R9 is a hydroxyl group, bromine, chlorine, flourine, hydroxamic acid group, amine, amide, or hydrogen; and
wherein A-B is a single bond representing a flavanone flavonoid.

US Pat. No. 10,765,655

COMPOSITION CONTAINING MONOACETYLDIGLYCERIDE COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Enzychem Lifesciences Cor...

1. A method of treating a chronic obstructive pulmonary disease in a patient, comprising administering to a patient in need of such treatment a pharmaceutically acceptable composition comprising an effective amount of a purified compound of Formula 2:

US Pat. No. 10,765,654

METHODS AND COMPOUNDS FOR TREATING CANCER

University of Vermont and...

1. A method for treating a cancer, the method comprising administering to a subject in need of treatment of a cancer, a glyceryltriacetate (GTA) compound in a therapeutically effective amount to treat the cancer, wherein the cancer is a glioma or a neuroblastoma.

US Pat. No. 10,765,652

REVERSIBLE NITROXIDE DERIVATIVES OF NITROALKENES THAT MEDIATE NITROSATING AND ALKYLATING REACTIONS

1. A composition comprising an effective amount of a fatty acid having a formula:
wherein X1 is H, n is from 1 to 10 and m is from 1 to 10; and
a pharmaceutically acceptable excipient.

US Pat. No. 10,765,651

CO-CRYSTALS OF SUBSTITUTED GLYCINE AND USES THEREOF

SyneuRx International (Ta...

1. A co-crystal comprising N-trimethylglycine and a co-former, wherein the co-former is a compound of Formula (IB):in which:A and B are both H or both OH;
W is O;
X is H;
Z is OH;
C2C1 are C2?C1 or C2-C1; and
wherein the molecular ratio between the N-trimethylglycine and the co-former in the co-crystal ranges from 1:1 to 2:1.

US Pat. No. 10,765,648

INKT CELL MODULATORS AND METHODS OF USING THE SAME

LUDWIG INSTITUTE FOR CANC...

1. A method of activating a natural killer T (NKT) cell in a human subject with ovarian cancer, the method comprising administering to a subject with ovarian cancer a composition comprising a compound, in an amount effective to activate the NKT cells, wherein the compound has a structure:
wherein n is 1, 2, or 3;
or a salt, ester, solvate, or hydrate thereof.

US Pat. No. 10,765,643

USE OF CANNABIDIOL IN THE TREATMENT OF EPILEPSY

GW Research Limited, Cam...

1. A method of treating seizures in a subject having Aicardi Syndrome, comprising administering to the subject in need thereof cannabidiol (CBD),wherein the CBD is present in a composition at a concentration ranging from about 25 mg/ml to about 100 mg/ml, ethanol is present in the composition at a concentration of about 79 mg/ml, sucralose at a concentration of about 0.5 mg/ml, strawberry flavoring is present in the composition at a concentration of about 0.2 mg/ml and sesame is present in the composition at an amount up to about 1.0 ml.

US Pat. No. 10,765,638

PARTICLE FORMULATION WITH POLYCATION COMPLEX

YALE UNIVERSITY, New Hav...

1. Particles for delivery of one or more small molecule, non-polymeric therapeutic, prophylactic or diagnostic agents comprisinga) a core comprising a complex formed by the ionic association of the one or more small molecule, non-polymeric therapeutic, prophylactic, or diagnostic agents and one or more polycationic polymers, and
b) an outer layer comprising one or more amphiphilic block copolymers non-covalently associated on the outside of the complex.

US Pat. No. 10,765,636

MESOPOROUS SILICA NANOPARTICLES WITH A LIPID BILAYER COATING FOR CARGO DELIVERY

The Regents of the Univer...

1. A method of treating cancer, comprising administering to a subject in need thereof an effective amount of a nanoparticle drug carrier, wherein the nanoparticle drug carrier comprises:a) a silica nanoparticle having a surface and defining a plurality of pores;
b) a lipid bilayer coating the surface;
c) a protonating agent disposed within the plurality of pores where said protonating agent is an ammonium salt, a trimethylammonium salt, a triethylammonium salt, or an ionophore combined with a metal salt; and
d) a drug disposed within the plurality of pores, wherein said drug consists of irinotecan, and wherein the nanoparticle drug carrier has a drug loading capacity of at least about 40% w/w.

US Pat. No. 10,765,633

FORMULATION COMPRISING LIPOSOMES

1. A formulation comprising liposomes, wherein the liposomes comprise, based on the liposome, 0.7 to 3.0 mol % of eritoran or a pharmaceutically acceptable salt thereof, a PEGylated phospholipid and 0 to 10 mol % of a sterol, wherein the molar ratio range of the eritoran or a pharmaceutically acceptable salt thereof and the PEGylated phospholipid is 1:0.4 to 1:2.5.

US Pat. No. 10,765,627

IMMUNOGENIC COMPOSITION AGAINST CAMPYLOBACTER JEJUNI

The United States of Amer...

1. A polysaccharide antigen for inducing an immune response against Campylobacter jejuni, said polysaccharide antigen comprising an isolated Campylobacter jejuni capsule polysaccharide from a Campylobacter jejuni strain linked to form a repeating polysaccharide polymer comprising 2 or more of said capsule polysaccharides, wherein said Campylobacter jejuni strain is selected from the group consisting of: HS4, HS5, HS4/13/64, and HS50, wherein said polysaccharide antigens do not contain Campylobacter jejuni lipooligosaccharide structures associated with Guillain Barré Syndrome, wherein said polysaccharide polymer is conjugated to a protein carrier, wherein the structure of HS4 is ?3)-L-?-D-ido-Hep-(1?4)-?-D-GlcNAc-(1?, with non-stoichiometric MeOPN at C-4 of LD-ido-Hep, wherein the structure of HS4/13/64 is [?3)-6d-?-D-ido-Hep-(1?4)-?-D-GlcNAc-(1?]n, with non-stoichiometric MeOPN at C-2 and/or C-7 of 6d-ido-Hep, wherein the number of repeats of a capsule polysaccharide “n” is 1 to 100, and wherein the structure of HS5 is selected from the group consisting of

US Pat. No. 10,765,620

ORGANIC FOAMING SOAP COMPOSITION AND DISPENSER

1. An organic, plant-based moisturizing anti-microbial hand soap composition comprising,a) a base soap, comprising: saponified organic coconut oil; saponified organic olive oil; saponified organic sunflower oil; saponified organic jojoba oil; and organic aloe vera, wherein said base soap comprises about 90.80 wt. % of the composition;
b) a plurality of anti-microbial active ingredients comprising: organic shea butter; organic spearmint oil; USDA approved lime oil; organic thyme oil; and organic rosemary extract;
wherein said composition does not comprise sulfites, non-organic plant-based chemicals, or synthetic compounds;
wherein said composition is effective as a moisturizing antimicrobial soap, a leave-on non-sticky hand sanitizer, and an air freshener by absorbing and reducing odor causing airborne bacteria; and
wherein the composition is able to eradicate about 74.6% through 77.6% of the bacterial strain Staphylococcus aureus after at least one minute of direct contact with the composition.

US Pat. No. 10,765,616

ORAL FORMULATION OF POLYGLUCOSAMINE DERIVATIVES IN COMBINATION WITH A NON-FERMENTABLE SUGAR

SYNEDGEN, INC., Claremon...

1. A method of treating dry mouth, the method comprising administering to a subject an oral care aqueous composition comprising:sorbitol present in the composition at an amount from about 5% to about 35% by weight of the composition;
xylitol present in the composition at an amount from about 2% to about 15% by weight of the composition; and
a poly (acetyl, arginyl) glucosamine (PAAG), wherein PAAG comprises the following formula (I):
wherein:n is an integer between 20 and 6000; andeach R1 is independently selected for each occurrence from hydrogen, acetyl,wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents arethe molecular weight of the PAAG is from 20 to 200 kDa, and wherein the PAAG is present in the composition at an amount of at least 0.003% to about 0.05% w/v of the composition.

US Pat. No. 10,765,615

USE OF PARTICULAR PYRIDINIUM SALTS FOR THE TREATMENT OF KERATIN SUBSTANCES, COMPOSITIONS AND IMPLEMENTATION METHODS

1. A method for treating keratin substances, the method comprising applying to the keratin substances at least one compound chosen from compounds represented by formula (I), addition salts thereof, or solvates thereof:
wherein:
R1, R2, R3, R4 and R5, which may be identical or different, each represent:
a hydrogen or halogen atom;
a linear or branched C1-C10 alkyl substituent, optionally substituted by one or more hydroxyl, C1-C10 alkoxy, C1-C4 hydroxyalkyl and —NR7R8 groups;
a linear or branched C1-C10 alkoxy substituent, optionally substituted by one or more hydroxyl, C1-C10 alkoxy, C1-C4 hydroxyalkyl and —NR7R8 groups;
or two adjacent substituents R1 and R2, R2 and R3, R3 and R4 and/or R4 and R5 can form together with the carbon atoms to which they are attached a cycloalkyl group including 5 to 10 members or an aryl group including 6 to 10 members, it being understood that said cycloalkyl or aryl group optionally comprises one or more heteroatoms and is optionally substituted by one or more halogen atoms, one or more linear or branched C1-C10 alkyl substituents, one or more linear or branched C1-C10 alkoxy substituents, one or more hydroxyl groups, one or more C1-C4 hydroxyalkyl substituents and one or more —NR7R8 groups;
ALK represents a linear or branched, saturated or unsaturated C1-C10 alkyl substituent;
R6 represents:
a hydrogen or halogen atom,
a linear or branched, saturated or unsaturated C1-C10 alkyl substituent, optionally interrupted by one or more heteroatoms chosen from oxygen and nitrogen and/or optionally substituted by one or more hydroxyl, C1-C10 alkoxy, C1-C4 hydroxyalkyl and —NR7R8 groups;
an aryl substituent including 5 to 12 members optionally substituted by one or more halogen atoms, one or more linear or branched C1-C10 alkyl substituents, one or more linear or branched C1-C10 alkoxy substituents, one or more hydroxyl groups, one or more C1-C4 hydroxyalkyl substituents and one or more —NR7R8 groups;
X represents a heteroatom chosen from an oxygen atom or a sulfur atom, or a —NR11 substituent;
R7, R8, and R11, which may be identical or different, denote a hydrogen atom or a linear or branched C1-C10 alkyl substituent optionally substituted with one or more hydroxyl or C1-C10 alkoxy, C1-C4 hydroxyalkyl and amino groups;
wherein one of the substituents R1 or R5 may form a ring with the substituent R6;
Q? represents an anion or a mixture of organic or inorganic anions that ensure electroneutrality in compounds of formula (I).

US Pat. No. 10,765,607

THERMALLY ASSISTED THERAPEUTIC AIDS FOR COSMETICS AND WOUND TREATMENT

ALPS SOUTH EUROPE S.R.O.,...

1. A thermally assisted therapeutic aid comprising:a single, contiguous, material layer, wherein the material layer is composed of an open cell foam, felt, knit, weave of hydrophobic or amphiphilic or hydrophilic fibers, non-woven fabric or their combinations thereof comprising a therapeutic agent homogeneously dissolved in the material layer;
a phase change material layer comprising a phase change material; and
a fabric layer configured to secure the aid relative to an appendage.

US Pat. No. 10,765,606

METHOD AND APPARATUS FOR BABY BOTTLE HOLDER

1. A nursing bottle holder comprisinga substantially planar support frame comprising
a partially circular top portion having a diameter and comprising
a rounded first side having an inside surface, a top, and a bottom,
a rounded second side having an inside surface, a top, and a bottom, the rounded second side spaced apart from the rounded first side, and an opening between the rounded first side and the rounded second side, the opening configured to accept a portion of a baby bottle, such that the top of the rounded first side is joined to the top of the rounded second side, and the bottom of the rounded first side is spaced apart from the bottom of the second rounded side,
an arced bottom portion having a first side, a second side, and having a length greater than or equal to the diameter of the top portion,
a rounded elongated first side member having a first thickness defined by a first outer surface and a substantially parallel first inner surface, wherein the first thickness is configured to be grasped by a baby, extending from the arced bottom first side to the rounded first side bottom, and
a rounded elongated second side member having a second thickness defined by a second outer surface and a substantially parallel second inner surface, wherein the second thickness is configured to be grasped by a baby, spaced apart from the rounded elongated first side member, and
extending from the arced bottom second side to the rounded second side bottom; and
a bottle gripping element lining at least a portion of the inside surface of the rounded first side, and lining at least a portion of the inside surface of the rounded second side.

US Pat. No. 10,765,604

DRUG VIAL ADAPTER ASSEMBLAGES INCLUDING VENTED DRUG VIAL ADAPTER AND VENTED LIQUID VIAL ADAPTER

1. A dual vial adapter assemblage for use with a drug vial, a liquid vial and a needleless syringe, the drug vial having a drug vial bottle and a drug vial stopper sealing the drug vial bottle, the drug vial containing a medicament, the liquid vial having a liquid vial bottle and a liquid vial stopper sealing the liquid vial bottle, the liquid vial containing liquid contents for mixing with or reconstituting the medicament in the drug vial to form a liquid drug therein, the needleless syringe being empty, the dual vial adapter assemblage having a longitudinal dual vial adapter assemblage centerline and comprising:a vented drug vial adapter having a longitudinal drug vial adapter centerline and including a transverse drug vial adapter top wall with an upright drug vial adapter connector, an oppositely directed drug vial adapter skirt for telescopic mounting on the drug vial, and a dual lumen drug vial stopper puncturing cannula for puncturing the drug vial stopper on said telescopic mounting of said vented drug vial adapter on the drug vial, said dual lumen drug vial stopper puncturing cannula having i) a liquid lumen in flow communication with said drug vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings; and
a vented liquid vial adapter having a longitudinal liquid vial adapter centerline and including a transverse liquid vial adapter top wall with an upright liquid vial adapter connector, an oppositely directed liquid vial adapter skirt for telescopic mounting on the liquid vial, and a dual lumen liquid vial stopper puncturing cannula for puncturing the liquid vial stopper on said telescopic mounting of said vented liquid vial adapter on the liquid vial, said dual lumen liquid vial stopper puncturing cannula having i) a liquid lumen in flow communication with said liquid vial adapter connector and ii) a vented air lumen openly vented to the ambient surroundings,
the vented drug vial adapter and the vented liquid vial adapter being formed as discrete components,
at least one of said dual lumen drug vial stopper puncturing cannula and said dual lumen liquid vial stopper puncturing cannula further comprising a tip located on the longitudinal drug vial adapter centerline or the longitudinal liquid vial adapter centerline,
the arrangement being such that in a set-up position of the dual vial adapter assemblage in which said drug vial adapter connector is connected to, and in flow communication with said liquid vial adapter connector, on initial telescopic mounting of said vented liquid vial adapter on the liquid vial and said vented drug vial adapter on the drug vial, said liquid lumen of said vented drug vial adapter and said liquid lumen of said vented liquid vial adapter collectively define a nonrectilinear fluid flow path from said liquid vial to said drug vial, and subsequent disposing of the liquid vial above the drug vial leads to gravitational flow of liquid contents from the liquid vial to the drug vial for forming the liquid drug therein assisted by simultaneous venting of the liquid vial by drawing ambient air thereinto through said dual lumen liquid vial stopper puncturing cannula's vented air lumen and the drug vial by expelling air therefrom through said dual lumen drug vial stopper puncturing cannula's vented air lumen to the ambient surroundings,
the drug vial adapter being detachable from the liquid vial adapter for providing access to the drug vial adapter connector for enabling connection of the empty needleless syringe thereto for aspiring a liquid drug dosage from the drug vial for administration to a patient.

US Pat. No. 10,765,603

MEDICAL CONTAINER

Naturan International Co....

1. A medical container which can be opened and closed with a sealing fastener, and which is configured to enclose a solid preparation therein, the medical container comprising:an exterior sheet comprising a first layer sheet and a second layer sheet, the first layer sheet and the second layer sheet overlapping with one another in a direction from an inner surface side of the exterior sheet to an outer surface side of the exterior sheet,
wherein the first layer sheet comprises an inner sheet and an adjacent outer sheet,
wherein the inner sheet is configured to absorb water, permit passage of water vapor and not permit passage of liquid water,
wherein a hydrogen-generating substance for generating hydrogen gas by reacting with moisture is kneaded into the outer sheet, and the hydrogen-generating substance generates hydrogen when moisture that passes through the inner-sheet contacts the hydrogen-generating substance in the outer sheet, and
wherein the second layer sheet is a barrier layer that comprises aluminum foil.

US Pat. No. 10,765,601

SEPTUM HOLDERS FOR USE IN SYRINGE CONNECTORS

EQUASHIELD MEDICAL LTD., ...

1. A septum holder comprising: a body having a disk shaped annular lower body portion and an upper body portion comprised of at least two vertical posts and at least one horizontal bar; an insert comprising at least one bore that forms a seat of a needle valve, the insert fixedly supported between the at least one horizontal bar in the upper body portion and the lower body portion of the septum holder body; at least one resilient elongated arm terminating with a distal enlarged element attached to sides of the vertical posts of the upper body portion; and a septum attached to and extending downward from a bottom surface of the lower body portion of the septum holder body, the septum extending downward parallel to the at least one arm;wherein the septum is made of a single piece of cylindrically shaped resilient material comprising an upper part that is attached to the bottom surface of the lower body portion of the septum holder body and a lower part having a diameter that matches that of a septum in a fluid transfer component.

US Pat. No. 10,765,600

ADAPTER FOR USE IN A PLANETARY MIXER

1. In combination:a jar with a top, an inner wall and a bottom,
a dispensing container having at least a body and a removable cap; and
an adapter for the dispensing container, the adapter having a central aperture through which a longitudinal axis of the jar passes when the adapter is positioned inside the jar, the central aperture being smaller than the removable cap of the dispensing container;
wherein when the dispensing container is secured to the adapter and the adapter is positioned inside the jar: (i) the adapter is configured to maintain the dispensing container spaced from the inner wall of the jar and from the bottom of the jar; (ii) a gap is provided between the top of the jar and the cap of the dispensing container; (iii) a part of the cap of the dispensing container is further from the bottom of the jar than a part of the body of the dispensing container; (iv) the body of the dispensing container crosses the longitudinal axis of the jar; and (v) the dispensing container extends over more than half a width of the jar, and
wherein the inner wall of the jar is tapered and wherein the inner wall and the adapter are configured such that the distance between the adapter and the inner wall varies as the adapter extends further into the jar.

US Pat. No. 10,765,599

DEVICE FOR REDUCING MEDICATION NON-ADHERENCE

Sherif Badawy, Chicago, ...

1. An accessory for increasing medication adherence in pediatric patients, comprising:a body having an aesthetic design, said body made of plastic and having a top surface;
a circular opening in the top of the body, the circular opening having a diameter;
an interior wall defining a cylindrical cavity extending downward from the opening and having a substantially closed floor and an upper rim, the cylindrical cavity further having a substantially constant diameter, wherein said upper rim is flush with the top surface of the body;
wherein the diameter of the opening is substantially equal to the diameter of the cylindrical cavity;
wherein the cylindrical cavity is adapted to hold a pill bottle selected from the group consisting of a 6 dram pill bottle, a 8 dram pill bottle, a 13 dram pill bottle, a 16 dram pill bottle, a 20 dram pill bottle, a 30 dram pill bottle, and a 40 dram pill bottle,
wherein the cylindrical cavity has a diameter between about 101% and about 115% of a diameter of said selected pill bottle;
wherein the cylindrical cavity has a depth between about 80% and about 95% of a height of said selected pill bottle; and
wherein the cylindrical cavity is adapted to hold said selected pill bottle in an upright position.

US Pat. No. 10,765,598

NEGATIVE PRESSURE DEVICE AND METHODS THEREOF

Yun Yu Cheung, Sheung Sh...

1. A method of operating a negative pressure device during an acupuncture treatment, comprising the steps of:acupuncturing at least one hollow needle under a skin of a patient to a subcutaneous connective tissue at one or more acupoints associated with the acupuncture treatment, each of the at least one hollow needle comprising a through hole,
connecting the at least one hollow needle to a host machine, the host machine comprising a vacuum pump, and
establishing a negative pressure in the through hole of the at least one hollow needle by means of the vacuum pump for a predetermined period of time to ensure no air or drug enters the one or more acupoints so as to dredge one or more meridians or collaterals of a body of the patient.

US Pat. No. 10,765,597

SAUNA HEATING APPARATUS AND METHODS

HIGH TECH HEALTH INTERNAT...

1. An infrared apparatus for a sauna, said sauna including a plurality of walls that define an internal space, said infrared apparatus to heat said internal space, said infrared apparatus comprising:a first layer having a first conductive path coupled to pass a current;
a second layer having a second conductive path running coincident to said first conductive path; and
a third layer situated between an interior of said internal space and said first and second layers,
wherein at least one of said first conductive path and said second conductive path includes a resistive heating element that produces heat from said current,
wherein said first conductive path is coupled to redirect said current to said second conductive path and set up complementary magnetic fields between said first and second layers, and
wherein said third layer substantially blocks an electric field produced from the resistive heating element included in the at least one of said first layer and said second layer.

US Pat. No. 10,765,596

ORAL STIMULATOR DEVICE

GUMMER LLC, Palm Harbor,...

1. An oral stimulating device for inserting within a mouth of an individual and engaging over the teeth, the oral stimulating device adapted to contact a second individual, the oral stimulating device, comprising:a primary member defining a lower surface, an upper surface, an interior surface and an exterior surface;
a secondary member defining a lower surface, an upper surface, an interior surface and an exterior surface;
an arcuate member defining a lower surface, an upper surface, an interior surface and an exterior surface;
said arcuate member coupling said primary member with said secondary member for defining a general U-shaped mouthpiece;
a first plurality of lower protruding knobs coupled to said lower surface of said primary member and configured to contact the second individual;
a second plurality of lower protruding knobs coupled to said lower surface of said secondary member and configured to contact the second individual;
a third plurality of lower protruding knobs coupled to said lower surface of said arcuate member and configured to contact the second individual; and
said first plurality of protruding knobs, said second plurality of protruding knobs and said third plurality of protruding knobs adapted to provide oral stimulation, to the second individual.

US Pat. No. 10,765,594

MASSAGE FOAM ROLLER APPARATUS AND SYSTEM

Michael A. Sanchez, Plea...

1. A hollow, therapeutic massage roller apparatus comprising:first and second elongated, partially cylindrical, roller pad sub-assemblies, each including a length of rigid substrate material having a layer of resilient foam material affixed to a convex outer surface thereof, said first and second elongated, partially cylindrical, roller pad sub-assemblies having side edges adapted to mate together to form an elongated, hollow cylindrical roller body with said layers of resilient foam material forming a therapeutic roller surface having a transverse first outer diameter, said hollow cylindrical roller body including a first end and a second end opposite to the first end, and wherein each of the first and second ends includes a plurality of notches; and
a pair of cylindrical end caps closed on a first axial end thereof and open on a second axial end thereof, the second axial end of each of the pair of cylindrical end caps being adapted to mate with one of said first and second ends of the elongated hollow cylindrical roller body to form a closed container, said pair of cylindrical end caps each having a cylindrical outer surface of a second transverse diameter greater than the transverse first outer diameter of said therapeutic roller surface to form supporting rollers surfaces adapted to separate the therapeutic roller surface from a surface upon which the hollow, therapeutic massage roller apparatus is intended to roll or rest when in use, each of said pair of cylindrical end caps further including a cylindrical outer cap shell having an opening, a container cap, and a rotatable locking plate having a plurality of snap fasteners and a plurality of locking tabs,
wherein the rotatable locking plate is positioned within the opening of the cylindrical outer cap shell, and the rotatable locking plate is configured to rotate relative to the cylindrical outer cap shell, the plurality of snap fasteners of the rotatable locking plate are configured to engage the container cap, and the plurality of locking tabs of the rotatable locking plate on each pair of cylindrical end caps are configured to engage with the plurality of notches.

US Pat. No. 10,765,592

SYSTEM AND METHOD FOR DETERMINING A FILL STATUS OF A CANISTER OF FLUID IN A REDUCED PRESSURE TREATMENT SYSTEM

KCI Licensing, Inc., San...

1. An apparatus for determining a fill level of a container in a tissue treatment system, the apparatus comprising:a processing unit configured to:
sense a reduced pressure in a source conduit;
vent the reduced pressure in the source conduit for a select amount of time; and
determine a fill level of the container based on a decay of reduced pressure in the source conduit over the selected amount of time.

US Pat. No. 10,765,590

FOAM GENERATOR FOR INVERTED COMPRESSION RECEPTACLES

APOLLO INDUSTRIAL CO., LT...

1. A foam generator for inverted compression receptacles, the foam generator comprising:an inverted compression receptacle having liquid contents stored therein, the inverted compression receptacle having a neck disposed at a lower part of the inverted compression receptacle, the neck having screw threads formed therein;
a cap main body comprising a large cap part fastened to the neck of the inverted compression receptacle in a screw coupling manner, an upward and downward movement guide wall disposed at an outside of the large cap part, the upward and downward movement guide wall being formed in a shape of a cylinder, a foam discharge part protruding from a lower part of the large cap part in a shape of a pipe having a reduced diameter, a step formed at an upper end of the foam discharge part, a lower part of the foam discharge part being open, and an air hole for allowing external air to be introduced therethrough being formed in the step;
a content discharge guide having an edge fitted in a lower side of the large cap part of the cap main body so as to be spaced apart from an upper part of the step of the cap main body, the content discharge guide comprising a discharge guide part having a liquid discharge port formed in a central region of the discharge guide part so as to be recessed concavely and a cylindrical discharge channel protruding from an upper part of a center of the discharge guide part for guiding a discharge of the liquid contents, the discharge guide part having an air discharge port disposed at an edge of the discharge guide part, through which air in the inverted compression receptacle can move to a lower side of the discharge guide part when the inverted compression receptacle is compressed, and having an air introduction port, through which external air is introduced into the inverted compression receptacle when the inverted compression receptacle is restored to an original state thereof;
a valve housing comprising a cylindrical coupling part fitted into an upper part of the content discharge guide so as to cover the upper part of the content discharge guide such that an air compartment, which communicates with the air discharge port and the air introduction port, is defined in the cylindrical coupling part, the cylindrical coupling part having a content suction port disposed in a central region of the cylindrical coupling part, the cylindrical coupling part being coaxially fitted into the discharge channel defined in the content discharge guide, a content check valve for selectively opening and closing the content suction port depending on whether the inverted compression receptacle is compressed, and a tube fitting port protruding from an upper surface of the valve housing so as to communicate with the air compartment;
an air tube having a lower end fitted into the tube fitting port of the valve housing and an upper end extending toward an upper part of the inverted compression receptacle, for allowing an upper space in the inverted compression receptacle 100, in which air remains, and the air compartment to communicate with each other therethrough;
an air check valve unit made of an elastic material, the air check valve unit comprising a ring-shaped partition wall having an upper end disposed in tight contact with a lower surface of the content discharge guide and a lower end disposed in tight contact with an upper part of the step of the cap main body for defining an air and liquid mixing chamber in the foam discharge part, a first check valve part disposed inside the partition wall so as to extend upward toward a central part of the air check valve unit, an end of the first check valve part being disposed in elastically tight contact with the discharge guide part of the content discharge guide, the first check valve part being configured to allow the air in the inverted compression receptacle to move to the air and liquid mixing chamber through the air discharge port when the inverted compression receptacle is compressed, and a second check valve part disposed outside the partition wall so as to extend downward toward an outside of the air check valve unit, an end of the second check valve part being disposed in elastically tight contact with an outside of the step of the cap main body, the second check valve part being configured to close the air hole when the inverted compression receptacle is compressed and to open the air hole when the inverted compression receptacle is restored to the original state thereof such that external air can be introduced;
a filtration member fitted in the foam discharge part of the cap main body, the filtration member being formed in a shape of a cylinder having open upper and lower parts, the filtration member being provided at upper and lower surfaces thereof with filtration nets, the filtration member being configured to guide a discharge of foam formed as a result of the liquid contents being mixed with air in the air and liquid mixing chamber while homogenizing the foam; and
an upward and downward movement cap comprising a cylindrical wall surface having an upper end coupled to the upward and downward movement guide wall of the cap main body so as to be movable upward and downward and a lower surface configured to cover a lower part of the cap main body, the lower surface being provided with a plurality of foam distribution holes, through which the foam that has passed through the filtration member is discharged to the outside in a distributed manner, the upward and downward movement cap having a cylindrical blocking wall disposed at a center of the lower surface of the upward and downward movement cap in a protruding manner for selectively opening and closing the foam discharge part according to an upward and downward manipulation of the upward and downward movement cap.

US Pat. No. 10,765,589

THERAPEUTIC DEVICE FOR TREATMENT OF HEADACHE AND PAIN

1. A therapeutic device for treatment of headaches, comprising:a body extending in a longitudinal direction along a longitudinal axis configured to provide support to a patient's neck; a pair of feet or stands attached to the body for stabilizing the body and arranged in the longitudinal direction;
a pressure applicator device comprising a first applicator and a second applicator each extending radially from the body and configured to apply pressure via at least two points on suboccipital muscles of the patient, wherein the first applicator and the second applicator are capable of translational movement relative to one another along the longitudinal axis to alter a spacing thereinbetween and relative positions of the at least two points at which to apply pressure to the suboccipital muscles; and
a first knob and a second knob, the first knob and the second knob are separate but attached to the body, wherein the first knob and the second knob are centered along and configured for rotation about the longitudinal axis,
wherein the pressure applicator device is configured to be adjustable via the first knob and the second knob so that the at least two points through which the pressure is applied to the suboccipital muscles of the patient is altered,
wherein the first knob is configured to be rotated along the longitudinal axis to adjust an angular position of the body about the longitudinal axis relative to the pair of feet or stands to adjust the angular position of the first applicator and the second applicator, and wherein the second knob is configured to adjust the spacing between the first applicator and the second applicator.

US Pat. No. 10,765,588

INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESSING METHOD

SONY CORPORATION, Tokyo ...

1. An information processing apparatus, comprising:an image sensor configured to capture a current image at a specific time duration after a start of walk of a person; and
a central processing unit (CPU) configured to:
compare the current image and a reference image, wherein a time of capture of the reference image corresponds to the specific time duration;
determine a first direction of the walk of the person based on the comparison of the current image and the reference image; and
generate guide information for the person based on the determined first direction, wherein the guide information indicates the person to walk in the first direction.

US Pat. No. 10,765,587

WALKER ATTACHMENT FOR WHEELCHAIRS

GARDNER MEDICAL, LLC, Sh...

1. A walker for use by a user, said walker adapted for connection to a wheelchair including a frame, the walker comprising:a first vertical rod and a second vertical rod adapted to assist in supporting the user when the walker is in a walking position;
a gate rotatable about a longitudinal axis of the first vertical rod, said gate being removably connectable to the second vertical rod, wherein the gate is connected to the second vertical rod in the walking position and is disconnected from the second vertical rod in a stored position;
at least two wheelchair attachment supports adapted for removable connection to the frame of the wheelchair when the walker is in the walking position; and
at least one clamp assembly associated with each of the wheelchair attachment supports, said clamp assembly adapted for removable connection of the each of the wheelchair attachment supports and the frame of the wheelchair when the walker is in the walking position, wherein the at least one clamp assembly comprises a clamp body including a recess defined by a base connecting two sides, and the clamp assembly further comprises a sliding head adapted to slide within the recess to capture and hold one of the wheelchair attachment supports and the frame of the wheelchair within the clamp body.

US Pat. No. 10,765,586

WALKING AID DEVICE

Wistron Corporation, New...

1. A walking aid device, comprising:a moving body, the moving body has a seat and a handle;
a message receiving element, disposed at the moving body and configured to receive a message from a target;
a positioning element, disposed at the moving body and configured to locate a position of the moving body; and
a processor, disposed at the moving body and electrically coupled to the message receiving element and the positioning element, wherein when the message receiving element receives the message from the target, the processor determines an orientation of the target according to the message, and the positioning element locates the position of the moving body, the processor produces a position data according to the orientation of the target and the position of the moving body, and controls the moving body to move to where the target is located according to the position data, and controls the seat or the handle to rotate according to the message.

US Pat. No. 10,765,585

WALKING ASSISTANCE ROBOT FOR ASSISTING SMOOTH START OF USER'S ACTION AFTER STANDING UP FROM CHAIR

PANASONIC INTELLECTUAL PR...

1. A walking assistance robot comprising:a body;
a rotor that moves the walking assistance robot;
a handle that is provided to the body and that a user is able to hold;
a sensor that detects a handle load imposed on the handle;
a processor, and
a memory storing a computer program, which when executed by the processor, causes the processor to perform operations including:
receiving consciousness level information on a consciousness level of the user via a network;
performing resistance force control, in which resistance force applied to rotation of the rotor is controlled based on the received consciousness level information; and
terminating the resistance force control so that the resistance force is not applied to the rotor, based on the handle load detected by the sensor.

US Pat. No. 10,765,584

FOLDABLE FRAME CONSTRUCTION FOR MOBILITY AIDS

1. A foldable frame construction for mobility aids comprising:a mounting frame having
a fixed end;
a limiting end being opposite to the fixed end of the mounting frame;
a limiting hole formed through the mounting frame adjacent to the limiting end of the mounting frame;
a through hole formed through the mounting frame between the fixed end and the limiting hole of the mounting frame;
two pivot holes formed through the mounting frame at a spaced interval to dispose the through hole between the two pivot holes; and
a pivot shaft connected to one of the two pivot holes that is disposed between the through hole and the fixed end of the mounting frame;
a pivotal arm rotatably connected to the mounting frame and having
a pivotal end disposed away from the fixed end of the mounting frame;
a pressing end being opposite to the pivotal end of the pivotal arm; and
a positioning hole formed through the pivotal arm and selectively aligning with the through hole of the mounting frame;
a pivotal hole formed through the pivotal arm adjacent to the positioning hole, and aligning with the pivot hole of the mounting frame that is disposed between the limiting hole and the through hole; and
a pivotal rod connected to the pivotal hole and the corresponding pivot hole to enable the pivotal arm to pivot relative to the mounting frame; and
an operating element connected to the pivotal arm and the mounting frame to limit a position of the pivotal arm relative to the mounting frame, and having
a fixing ring base securely connected to the pivotal arm around the positioning hole;
an engaging bolt movably mounted in the fixing ring base and having
an inserting end selectively extending into the through hole via the positioning hole; and
a connecting end extending out of the fixing ring base and being opposite to the mounting frame; and
a pull button connected to the connecting end of the engaging bolt;
wherein when the pivotal arm is pivoted relative to the mounting frame to make the positioning hole align with the limiting hole, the engaging bolt is mounted in the positioning hole via the limiting hole;
a reinforcing rib connected to the mounting frame and the pivotal arm, and the reinforcing rib having
a connecting end connected to the fixed end of the mounting frame to hold the pivotal arm between the mounting frame and the reinforcing rib;
a linking end being opposite to the connecting end of the reinforcing rib, and pivotally connected to the pivotal arm and the mounting frame;
a curved segment formed on the reinforcing rib between the connecting end and the linking end of the reinforcing rib and surrounding the fixing ring base; and
two communicating holes formed through the reinforcing rib respectively at the connecting end and the linking end of the reinforcing rib, the communicating hole that is disposed at the connecting end of the reinforcing rib aligning with the pivot hole that is disposed adjacent to the fixed end of the mounting frame, and the communicating hole that is disposed at the linking end of the reinforcing rib aligning with the pivotal hole of the pivotal arm and the pivot hole of the mounting frame that is disposed adjacent to the limiting hole;
wherein the pivot shaft extends through the communicating hole that is disposed at the connecting end of the reinforcing rib, and is connected to the corresponding pivot hole to connect the reinforcing rib with the mounting frame, and the pivotal rod is connected to the reinforcing rib, the pivotal arm, and the mounting frame via the corresponding communicating hole, the pivotal hole, and the corresponding pivot hole.

US Pat. No. 10,765,583

WEARABLE WALKING ASSIST ROBOT AND METHOD FOR CONTROLLING THE SAME

Hyundai Motor Company, S...

1. A wearable walking assist robot, comprising:a sensor unit configured to sense pressure on the soles of the feet of a user; and
a controller configured to determine gait phases of both a first leg to be operated and a second leg based on the pressure sensed by the pressure sensor unit, select one of a plurality of control modes set in advance based on the determined gait phases, and operate a joint-driving unit for the first leg to be operated,
wherein the controller is configured to determine one selected from the group including a ground impact absorbing mode as a control mode for the first leg to be operated based on the gait phases of both the first leg to be operated and the second leg, and
wherein the ground impact absorbing mode is a mode in which the controller is configured to generate a virtual spring-damper in a longitudinal direction of a line connecting hip joint and an end of the first leg to each other of the walking assist robot and operate the joint-driving unit, using impedance control to make the first leg of the robot absorb shock from the outside.

US Pat. No. 10,765,582

APPARATUS FOR STIMULATING SYNCHRONIZED BODY MOTIONS OF A USER

Mopair Technologies Ltd.,...

1. An apparatus for imparting motion to a user comprising:one or more seat platforms;
one or more movable shoulder supports;
wherein at least one of said one or more seat platforms and said one or more movable shoulder supports is configured to rotate around a vertical axis;
a stationary lower back support; and
a controller configured to control one or more actuators, each of said actuators coupled to at least one of: said one or more seat platforms and said one or more movable shoulder supports for repeatedly moving at least one of said one or more seat platforms and one or more movable shoulder supports around said vertical axis simultaneously to effect at least one of:
synchronized contra lateral shoulder and pelvic motion of the user; and
synchronized contra lateral shoulder and thigh motion of the user;
wherein said moving of said one or more seat platforms and one or more movable shoulder supports is with respect to said lower back support.

US Pat. No. 10,765,581

SPOOL FOR WINCH ACTUATOR

Dephy, Inc., Maynard, MA...

1. A spool assembly for a winch actuator, the spool assembly including,a spool extending along a central axis, the spool including
a first spool part extending along the central axis having a first clamping face and a first exit curve defining an end of the first clamping face; and
a second spool part extending along the central axis, the second spool part having a second clamping face and a second exit curve defining an end of the second clamping face; and
a belt disposed between the first spool part and the second spool part,
wherein the first clamping face and the second clamping face are offset from one another to define a clamping gap for the belt, and
wherein the first exit curve is disposed a first distance from the central axis and the second exit curve is disposed a second distance from the central axis, the first distance being smaller than the second distance.

US Pat. No. 10,765,580

PATIENT SECUREMENT SYSTEM FOR THE SURGICAL TRENDELENBURG POSITION

Augustine Biomedical and ...

1. A patient securing overlay with securement to a surgical table mattress or underbody support for use during surgery in the Trendelenburg position, comprising:a sheet of fabric configured to support a patient's torso on a surgical table;
the sheet of fabric having an upper surface configured to face the patient and a lower surface configured to face the surgical table mattress or underbody support;
the sheet of fabric includes friction enhancing elements applied to at least a portion of the upper surface;
the sheet of fabric includes an extension at a foot end of the sheet of fabric that provides material to be tucked under a foot end of the surgical table mattress or underbody support for securing the foot end of the sheet of fabric to the surgical table mattress or underbody support; and
the extension at the foot end of the sheet of fabric includes one or more friction enhancing elements that improve the friction bond between the sheet of fabric and either an underside of the surgical table mattress or underbody support;
wherein the extension at the foot end of the sheet of fabric is narrower than the sheet of fabric; and
the extension of the sheet of fabric at the foot end of the sheet of fabric anchors against a perineal cutout in the surgical table mattress or the underbody support such that the extension stretches to create a force vector that is directly opposite a force vector associated with the patient sliding down an incline of the surgical table when the surgical table is in the Trendelenburg position.

US Pat. No. 10,765,579

INCUBATOR FOR THE TRANSPORT OF HIGH-RISK INFANTS

GINEVRI S.R.L., Albano L...

1. A transport incubator comprisinga support structure comprising a base, provided with at least one first guide,
a housing structure, coupled with said support structure, comprising
a first portion having at least one first side panel slidably coupled with said at least one first guide of said base, and
a second portion, laterally delimited by at least one first side wall, wherein said at least one first side panel of said first portion slides on the at least one first side wall,
wherein said base is provided with a second guide, arranged parallel with respect to said at least one first guide,
said first portion comprises a second side panel, arranged facing to said at least one first side panel, slidably coupled to said second guide of said base, and
said second portion is delimited by a second side wall, arranged facing with respect to said at least one first side wall, wherein said second side panel slides on said second side wall.

US Pat. No. 10,765,578

ARTICLE FOR COLLECTING THE URINE AND STOOLS OF A USER

SWISS SAFE COLLECT SA, N...

1. An article for collecting urine and stools of a user, the article comprising:a support surface for supporting buttocks of the user; and
a chamber that communicates with an opening defined by the support surface and that presents a bottom portion; and
a spacer for maintaining the bottom portion at a distance from the support surface;
the chamber having an internal wall element that is situated at a position vertically intermediate between the support surface and the bottom portion and that is suitable for adopting a first configuration and a second configuration;
wherein, in the first configuration, the internal wall element subdivides the chamber into a top compartment and a bottom compartment, and forms an obstacle between these compartments that is suitable for retaining stools in the top compartment while putting the compartments into communication for urine, and wherein, in the second configuration, the obstacle is substantially eliminated so as to allow stools to pass into the bottom of the chamber; and wherein in the first configuration, communication between the bottom and top compartments comprises an opening that is substantially slot-shaped, a slot being defined by hinges formed in two reentrant folds in two flexible film portions placed facing each other, wherein said obstacle is formed by said two reentrant folds and the two flexible film portions are connected at top ends of said flexible film portions to the support surface and at bottom ends of said flexible film portions to the bottom portion, such that passing of the internal wall element from the first configuration to the second configuration may be caused by pulling the support surface upwards in a vertical direction of the article wherein said reentrant folds progressively unfold thereby increasing a width of said slot and permitting said stools to pass through said slot towards said bottom portion.

US Pat. No. 10,765,577

MICROCLIMATE SYSTEM FOR A PATIENT SUPPORT APPARATUS

Hill-Rom Services, Inc., ...

16. A method for controlling a microclimate system including a topper and an air box coupled to the topper to move pressurized air to the topper, the method comprising,detecting, using an immersion sensor, the immersion of a patient supported on the microclimate system into the topper,
determining if current operating parameters of the air box provide a rated level of heat withdrawal or evaporative capacity through the topper, based at least in part on the immersion detected by the immersion sensor, and
updating the current operating parameters of the air box to compensate for restriction of the air flow in the topper if the current operating parameters of the air box do not provide the rated level of heat withdrawal or evaporative capacity through the topper and the immersion sensor indicates that the amount of immersion of the patient into the support surface restricts the flow of air in the topper.

US Pat. No. 10,765,576

APPARATUS AND SYSTEM FOR BOOSTING, TRANSFERRING, TURNING AND POSITIONING A PATIENT

Sage Products, LLC, Cary...

1. An inflatable device for turning or positioning a person in a bed, the inflatable device comprising:an inflatable body formed by a top sheet and a bottom sheet disposed beneath the top sheet to define a cavity configured to be inflated such that the top sheet forms a top wall of the cavity and the bottom sheet forms a bottom wall of the cavity;
at least one port having a port opening in fluid communication with the cavity and configured to provide an air input for air for inflating the cavity, wherein the at least one port comprises an elastic member for adjusting a size of the port opening; and
a port sock comprising at least one side handle connected to the port sock adjacent the port opening.

US Pat. No. 10,765,575

PATIENT SUPPORT SYSTEMS WITH ROTARY ACTUATORS COMPRISING ROTATION LIMITING DEVICES

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a patient support surface;
a first member and a movable member, said movable member movable relative to said first member; and
an actuator comprising:
a gear assembly having an input element, an output element connected to said movable member, and a gear arrangement operable between said input element and said output element;
a motor configured to apply drive torque to said input element to rotate said output element through said gear arrangement; and
a rotation limiting device coupled to said gear assembly to permit movement of said movable member relative to said first member through application of said drive torque from said input element to said output element and prevent back drive torque applied to said output element from moving said movable member in at least one direction relative to said first member;
wherein said rotation limiting device comprises a braking surface and a braking element, said braking element operably coupled to said input element and said output element for concurrent movement with said input element and said output element, with said braking element engageable with said braking surface to prevent back drive torque applied to said output element from moving said movable member relative to said first member.

US Pat. No. 10,765,574

EASY TO USE PORTABLE MANUAL STANDING WHEELCHAIR WITH SAFETY FEATURES AND FOR OUTDOOR USE

INDIAN INSTITUTE OF TECHN...

1. A standing wheelchair comprising:a. a chassis having a first end and a rear end,
b. a front wheel connected to the front end of the chassis and a pair of rear wheels supporting the wheelchair,
c. a pivotable seat means of a first link (ab), the said seat pivotable between a generally horizontal seated position and an angled standing position, and having a seating surface and a backrest means of a second link (cd), such that (ab), (bc), (cd) and (da) form a four bar parallelogram link means,
d. a driver dyad means comprising of four links (be), (ef), (fg) and (bg) which is adapted to actuate the said 4-bar mechanism,
e. a pair of removably attached side handle actuator means, each handle actuator means connected rigidly to link (ef) of the driver dyad means and cooperatively associated with the 4-bar link means for actuating the seat means between the seated position and standing position,
f. a lockable knee support means attached to the front end of the said seat means moveable between a lock state and open operational state, and
g. a pair of side interlocking cam means, each interlocking cam means coupled to the knee support means and the corresponding side handle actuator means for causing the said handle actuator means to move only when the knee support means is in lock state.

US Pat. No. 10,765,573

WHEELCHAIR BRAKE SYSTEM

1. A wheelchair brake system comprising:a brake which is provided in a wheel of a wheelchair; and
a brake actuation controller which connects with the brake and locks and releases the brake,
wherein the brake is usually in a lock mode, but the brake actuation controller controls the brake to be switched over from the lock mode to a release mode when sensing that a load is applied to the wheelchair or the wheelchair is folded up;
wherein the brake actuation controller comprises:
a connection member which has a first end elastically connecting with the brake;
a brake switching member to which a second end of the connection member is fixed, and which actuates the connection member connecting with the brake to release the brake when the load is applied to the wheelchair, but returns the connection member to switch the brake over to the lock mode when the load is removed from the wheelchair,
wherein the connection member comprises a cable or a bar;
the brake switching member is non-motorized or motorized for automatic actuation, and
wherein the non-motorized brake switching member comprises:
a sensing frame which is provided beneath a seat of the wheelchair, and accommodates a second end of the cable therein to be fixed and connected thereto; and
an upper plate which couples with the sensing frame and changes tension of the cable by pressing the cable accommodated in the sensing frame when the load is applied to the seat.

US Pat. No. 10,765,572

METHOD OF ASSEMBLING AT LEAST TWO UNITS, AND A CORRESPONDING ASSEMBLED STRUCTURE

APLIX, Le Cellier (FR)

1. A method comprising:providing a first unit having a field of grip elements and a second unit provided with retention elements suitable for co-operating with the grip elements of the first unit in order to provide a self-gripping fastening;
putting the first and second units into contact in such a manner that the grip elements of the first unit and the retention elements of the second unit provide the self-gripping fastening; and
treating a treatment zone of the self-gripping fastening through a treatment in order to deform the grip elements of the first unit and/or the retention elements of the second unit, whereby the first and second units are permanently secured to each other, thereby forming an assembled structure,
wherein the treatment zone represents at least 50% of a total extent of the self-gripping fastening.

US Pat. No. 10,765,571

TAMPON DISPOSING SYSTEM

1. A tampon disposing system, comprising:a tampon;
a wrapper to encase the tampon therein; and
a bag attached to an inner side portion of the wrapper to store the tampon and at least a portion of the wrapper therein, the bag comprising:
an opening disposed outside a boundary of the wrapper.

US Pat. No. 10,765,570

ABSORBENT ARTICLES HAVING DISTRIBUTION MATERIALS

1. An absorbent article, comprising:a central longitudinal axis;
a liquid permeable topsheet;
a liquid impermeable backsheet;
an absorbent core positioned at least partially intermediate the topsheet and the backsheet, wherein the absorbent core comprises an absorbent material positioned within a core wrap, wherein the core wrap forms a C-wrap, and wherein the absorbent material comprises a substantially absorbent material free area surrounded on all sides by the absorbent material;
a distribution material positioned intermediate the topsheet and the core wrap and comprising two or more substrates, wherein a plurality of the two or more substrates comprise wet-laid, three-dimensional fibrous substrates comprising at least 80% pulp fibers by weight of the three-dimensional fibrous substrates, wherein the plurality of the three-dimensional fibrous substrates each comprise:
a continuous network region, wherein the continuous network region comprises a first average density; and
a plurality of discrete zones comprising a second average density, wherein the discrete zones are dispersed throughout the continuous network region, and wherein the first average density and the second average density are different;
an acquisition material positioned intermediate the topsheet and the distribution material; and
at least one of the two or more substrates is formed by folding the at least one substrate fully over itself, wherein the at least one substrate forms a dual layer at least in an area that overlaps the central longitudinal axis of the absorbent article.

US Pat. No. 10,765,568

ABSORBENT ARTICLE

DAIO PAPER CORPORATION, ...

1. An absorbent article comprising a front-surface sheet, a back-surface sheet, and an absorber interposed between the front-surface sheet and the back-surface sheet, wherein:the absorbent article is an incontinence pad for use in absorbing urine at a medium or more volume that is 20 cc or more;
the front-surface sheet is formed of a spunlace nonwoven fabric 100 wt % of which is composed of cotton fibers and which is coated with a water repellent agent, and has, at least at a portion corresponding to an excreting hole, numerous front-face/back-face penetrating openings that are longer shaped in the longitudinal direction of the absorbent article; and
the cotton fibers form numerous longitudinal streaks and numerous lateral streaks, the longitudinal streaks extending along the longitudinal direction of the absorbent article and being formed with an interval in the width direction of the absorbent article, and the lateral streaks extending along the width direction of the absorbent article and connecting together the longitudinal streaks formed with an interval in the longitudinal direction of the absorbent article; the openings are formed within portions surrounded by the longitudinal streaks and the lateral streaks; and the longitudinal streaks have more fibers and are formed at a higher density than the lateral streaks.

US Pat. No. 10,765,567

ABSORBENT ARTICLES WITH CHANNELS

1. An absorbent article comprising:a central longitudinal axis;
a total longitudinal length extending in a direction parallel to the central longitudinal axis;
a front waist region;
a rear waist region;
a crotch region positioned intermediate the front waist region and the rear waist region, wherein the front waist region, the rear waist region, and the crotch region each define ? of the total longitudinal length of the absorbent article;
a liquid permeable material;
a liquid impermeable material;
an absorbent core disposed at least partially intermediate the liquid permeable material and the liquid impermeable material and comprising an absorbent material, wherein the absorbent material is positioned within a core wrap, wherein the absorbent material comprises superabsorbent polymers, wherein the absorbent core defines a first channel, wherein the absorbent core defines a second channel, and wherein the first and second channels are free of overlap with the central longitudinal axis; and
a liquid management system positioned at least partially intermediate the liquid permeable material and the core wrap, wherein the liquid management system is free of any superabsorbent polymers, wherein the liquid management system defines a third channel and a fourth channel, wherein the third and fourth channels each extend into the front waist region, and wherein the third and fourth channels are free of overlap with the central longitudinal axis;
wherein the first channel has a first longitudinal length taken in the direction generally parallel to the central longitudinal axis, wherein the third channel has a second longitudinal length taken in the direction generally parallel to the central longitudinal axis, and wherein the first longitudinal length is greater than the second longitudinal length.

US Pat. No. 10,765,566

ABSORBENT ARTICLE WITH PARTIALLY SEPARABLE, SKIN-CONTACTING TOPSHEET LAYER

Kimberly-Clark Worldwide,...

1. An absorbent article having a longitudinal direction, a transverse direction, and a depth direction, said absorbent article having absorbent article opposing first and second longitudinal ends, and absorbent article opposing lateral side edges extending between said absorbent article opposing first and second longitudinal ends, said absorbent article comprising:a liquid permeable first topsheet layer having first topsheet layer opposing lateral side edges, and first topsheet layer opposing longitudinal ends;
a liquid permeable second topsheet layer subjacent, along said absorbent article depth direction, to said liquid permeable first topsheet layer, said liquid permeable second topsheet layer having second topsheet layer opposing lateral side edges, and second topsheet layer opposing longitudinal ends, and being attached at two opposing attachment zones to said liquid permeable first topsheet layer along or adjacent said first topsheet layer opposing lateral side edges, such that said liquid permeable first topsheet layer is unattached to said liquid permeable second topsheet layer at said first topsheet layer opposing longitudinal ends, and further such that continuous unattached areas are present at least partially across the absorbent article transverse direction between said two opposing attachment zones, said first and second liquid permeable topsheet layers being unattached from one another at said continuous unattached areas;
a liquid impermeable backsheet layer;
at least one absorbent core layer sandwiched between said liquid permeable second topsheet layer and said liquid impermeable backsheet layer along the absorbent article depth direction;
wherein said liquid permeable first topsheet layer is apertured such that there is at least one uninterrupted aperture opening extending through the entire thickness of said liquid permeable first topsheet layer to said liquid permeable second topsheet layer; and
wherein said article includes an additional layer subjacent to said liquid permeable second topsheet layer in the article depth direction, said additional layer including an aperture opening that is aligned with said aperture opening of said liquid permeable first topsheet layer along the article depth direction, and is sized and shaped similarly to said first topsheet layer aperture opening.

US Pat. No. 10,765,565

METHOD FOR MANUFACTURING TOPSHEETS FOR ABSORBENT ARTICLES

1. A method for manufacturing topsheets for absorbent articles, comprising the steps of:providing a continuous forming belt cycling about a set of guide rollers, the forming belt comprising an outer receiving side and an inner side, and comprising an air permeable substrate belt with an ordered arrangement of airflow blocking structures disposed thereon, the airflow blocking structures projecting in a z-direction outward from the substrate belt and having outermost land surfaces and a z-direction depth on the receiving side of the forming belt, whereby the belt has an arrangement of airflow permeable regions and airflow blocked regions corresponding with the ordered arrangement of airflow blocking structures;
providing a forming vacuum system below a working location through which the forming belt travels, and proximate its inner side, wherein the forming belt moves in a machine direction MD through the working location;
continuously introducing and entraining a flow of individual polymer streams into an air flow moving generally in a z-direction with respect to the working location of the forming belt;
continuously attenuating the polymer streams via the air flow, to form spun filaments;
continuously directing the air flow and entrained spun filaments to the working location;
using the forming vacuum system to continuously draw air in the air flow through the airflow permeable regions of the forming belt as they move along the machine direction through the working location, and thereby drawing the entrained filaments predominately toward and onto the airflow permeable regions, such that they accumulate to a greater second average basis weight over the airflow permeable regions and to lesser first average basis weight over the airflow blocked regions, to form a batt of accumulated filaments on the receiving side of the forming belt, whereby the batt is provided with an arrangement of built-up regions and attenuated regions corresponding with the ordered arrangement of airflow blocking structures on the forming belt;
compacting the batt against the forming belt via a compaction roller, whereby filaments in the attenuated regions are deformed by pressure between the land surfaces and the compaction roller; and
lifting the batt away from the forming belt;
wherein the airflow blocking structures are arranged on the forming belt in individualized single-topsheet configurations that substantially repeat sequentially on the forming belt along the machine direction, each single-topsheet configuration having a longitudinal axis and being configured to form a section of formed nonwoven web material comprised by a single topsheet having an in-use wearer-facing portion with an outer perimeter, each single-topsheet configuration comprising a configuration of one or more continuous channel-forming structures following one or a plurality of paths, the one or plurality of paths being substantially symmetric about the longitudinal axis and predominately circumscribing a discharge locus on the longitudinal axis, wherein the one or more continuous channel-forming structures extends across a central lateral axis of the single-topsheet.

US Pat. No. 10,765,564

FLEXIBLE ABSORBENT ARTICLE WITH A LOBED ABSORBENT LAYER

Kimberly-Clark Worldwide,...

1. An absorbent article characterized by comprising:a. a longitudinal direction, a transverse direction, and a depth direction;
b. a longitudinal axis and a transverse axis wherein the absorbent article is asymmetrical about the transverse axis;
c. a chassis comprising:
i. a first transverse direction end edge and a second transverse direction end edge;
ii. a topsheet layer comprising a first longitudinal direction peripheral edge and a second longitudinal direction peripheral edge;
iii. a backsheet layer comprising a first longitudinal direction peripheral edge and a second longitudinal direction peripheral edge;
iv. an absorbent system positioned between the topsheet layer and the backsheet layer, the absorbent system comprising a garment facing surface, a wearer facing surface, a first longitudinal direction peripheral region and a second longitudinal direction peripheral region, and at least two absorbent layers, wherein at least one of the absorbent layers of the absorbent system is a lobed absorbent layer comprising a first lobe and a second lobe wherein the first and second lobe define a longitudinally extending void space in the lobed absorbent layer, and wherein the lobed absorbent layer further comprises a transversely extending void space;
v. a first longitudinal direction bond region wherein the first longitudinal direction peripheral edge of the topsheet layer is bonded to the first longitudinal direction peripheral edge of the backsheet layer; and
vi. a second longitudinal direction bond region wherein the second longitudinal direction peripheral edge of the topsheet layer is bonded to the second longitudinal direction peripheral edge of the backsheet layer;
vii. at least one flexure feature wherein the at least one flexure feature comprises at least one flexure element extending in a direction generally parallel to the longitudinal axis and wherein the at least one flexure element is positioned within the void space; and
viii. a secondary flexure feature extending in a direction generally parallel to the transverse axis and positioned within the transversely extending void space; and
d. a first non-integral wing and a second non-integral wing, each of the first and second non-integral wings bonded to the backsheet layer.

US Pat. No. 10,765,563

INTRA-OPERATIVE SYSTEM FOR IDENTIFYING AND TRACKING SURGICAL SHARP OBJECTS, INSTRUMENTS, AND SPONGES

John Richard Dein, Fair ...

20. A method of intra-operatively identifying a used surgical sharp, the method comprising:(a) obtaining an initial count and an initial type of surgical sharp objects, wherein the initial count of the surgical sharp objects comprises an initial count of each type of the surgical sharp objects;
(b) counting and identifying used surgical sharp objects obtained from an operative sterile field to obtain a count and an identification of the type of the used surgical sharp objects, wherein for each of the used surgical sharp objects said counting and identifying comprises:
(1) imaging a used surgical sharp object obtained from the operative sterile field with a system comprising a surgical sharp object container and an intra-operative imaging device comprising a camera to obtain an Intra-operative surgical sharp object image data of the used surgical sharp object, wherein the used surgical sharp object is one that has been received from a surgeon, the used surgical sharp object is selected from the group consisting of a scalpel blade and a needle, and the surgical sharp object container comprises a first portion comprising the intra-operative imaging device, a second portion configured to hold the used surgical sharp object, and an opening in the second portion for receiving the used surgical sharp object; and
(2) identifying the used surgical sharp object from the intra-operative surgical sharp object image data with a system comprising an automated shape recognition module comprising a processor and a database of pre-existing surgical sharp object image data, wherein the automated shape recognition module counts and identifies the used surgical sharp object from the intra-operative surgical sharp object image data by comparing the intra-operative surgical sharp object image data with the pre-existing surgical sharp object image data, wherein a curvature of the imaged used surgical sharp object is used to identify the type of the used surgical sharp object via the automated shape recognition module;
(c) comparing the count of each type of the used surgical sharp objects with the initial count of each type of the surgical sharp objects;
(d) outputting a result corresponding to each type of the identified and counted used surgical sharp objects; and
(e) activating a notification device to provide a notification if the count of each type of the used surgical sharp objects differs from the initial count of each type of the surgical sharp objects.

US Pat. No. 10,765,562

APPARATUS FOR TRANSFERRING AND ROTATING AN OBJECT

GDM S.p.A., Bologna (IT)...

1. An apparatus for transferring and rotating an object from a retaining station to a releasing station along an annular transfer path, wherein the object has a first orientation in the retaining station which is different from a second orientation in the releasing station, wherein the apparatus comprises:a stator including a revolution body provided with a lateral surface;
a rotor being rotatable about a first rotation axis with respect to the stator;
at least one retaining head of the object connected to the rotor and including a retaining element being rotatable about a second rotation axis with respect to the rotor;
at least one first annular guide being arranged along the transfer path;
and wherein:
the stator includes a first cam profile being realized in said lateral surface and the retaining head includes a corresponding first follower cooperating and being coupled to the first cam profile, the first follower being suitable to cause the rotation of the retaining element about the second rotation axis as a function of the relative position of the first follower with respect to said first cam profile;
the stator includes a second cam profile;
the retaining head includes at least one first slide that supports the retaining element and that is slidingly coupled to the first annular guide;
the first slide is connected to the rotor by a mechanism provided with a second follower being adapted to be coupled to the second cam profile to cause the sliding of the first slide in the first annular guide as a function of the relative position of the mechanism with respect to said second cam profile;
the stator includes a front wall on which the second cam profile is realized; and
the rotor includes a circular body being interposed between the revolution body and the front wall.

US Pat. No. 10,765,561

SYSTEMS AND METHODS FOR USING NEGATIVE PRESSURE WOUND THERAPY TO MANAGE OPEN ABDOMINAL WOUNDS

1. A porous pad for the treatment of wounds using negative pressure, wherein the porous pad comprises:a porous material configured to channel wound exudate from a wound site and negative pressure to the wound site;
a generally planar shape with a thickness less than a width and a length, wherein the length is greater than the width and the generally planar shape has a major axis extending along the length and a minor axis extending along the width, the major and minor axes both bisecting the porous pad;
a first plurality of arcuate cuts or perforations extending through at least a portion of the thickness of the porous pad, the first plurality of arcuate cuts or perforations comprising a first arcuate cut or perforation arranged in series with a second arcuate cut or perforation, a first bridge portion disposed on the minor axis and between the first arcuate cut or perforation and the second arcuate cut or perforation, the first arcuate cut or perforation, the first bridge portion, and the second arcuate cut or perforation defining a first continuous arcuate shape;
a second plurality of arcuate cuts or perforations extending through at least a portion of the thickness of the porous pad, the second plurality of arcuate cuts or perforations disposed between the first continuous arcuate shape and the major axis, the second plurality of arcuate cuts or perforations comprising a third arcuate cut or perforation arranged in series with a fourth arcuate cut or perforation, a second bridge portion disposed on the minor axis and between the third arcuate cut or perforation and the fourth arcuate cut or perforation, the third arcuate cut or perforation, the second bridge portion, and the fourth arcuate cut or perforation defining a second continuous arcuate shape, wherein the third arcuate cut or perforation extends continuously from the second bridge portion to a third bridge portion disposed on the major axis, and the fourth arcuate cut or perforation extends continuously from the second bridge portion to a fourth bridge portion disposed on the major axis; and
a corresponding third arcuate cut or perforation disposed symmetrically across the major axis of the porous pad from the third arcuate cut or perforation, a corresponding fourth arcuate cut or perforation disposed symmetrically across the major axis of the porous pad from the fourth arcuate cut or perforation, and a fifth bridge portion disposed on the minor axis and between the corresponding third arcuate cut or perforation and the corresponding fourth arcuate cut or perforation, wherein the corresponding third arcuate cut or perforation extends continuously from the fifth bridge portion disposed on the minor axis to the third bridge portion disposed on the major axis, and the corresponding fourth arcuate cut or perforation extends continuously from the fifth bridge portion disposed on the minor axis to the fourth bridge portion disposed on the major axis.

US Pat. No. 10,765,560

TYMPANOSTOMY TUBE DELIVERY DEVICE WITH ELASTOMERIC BRAKE

TUSKER MEDICAL, INC., Me...

1. An instrument, comprising:a handpiece;
a boss member fixed relative to the handpiece;
a cam body rotatably supported within the handpiece and including a cam profile;
a shaft assembly;
a cam follower coupled to a portion of the shaft assembly and movably engaged with the cam profile of the cam body such that the cam profile and the cam follower are configured to cooperatively drive movement of the shaft assembly in response to a rotation of the cam body; and
a braking member extending along a portion of the cam body such that the boss member contacts the braking member when the cam body is in a cocked position, and wherein the braking member can progressively engage the boss member as the cam body rotates to brake the rotation of the cam body.

US Pat. No. 10,765,559

METHODS AND APPARATUSES FOR THE TREATMENT OF GLAUCOMA USING VISIBLE AND INFRARED ULTRASHORT LASER PULSES

1. A method of concurrently creating a plurality of openings in a trabecular meshwork of a patient's eye to conduct fluid from an anterior chamber into a Schlemm's canal of the eye, comprising:ablating a first crater to a first depth with first laser pulses;
ablating a second crater to a second depth with second laser pulses;
extending the first crater with third laser pulses to a third depth, the third depth different from the first depth; and
extending the second crater with fourth laser pulses to a fourth depth, the fourth depth different from the second depth;
wherein the first crater is extended to the third depth and the second crater is extended to the fourth depth after the second crater has been extended to the second depth, so as to penetrate the trabecular meshwork at the first location and the second location with decreased blood obscuration and form the plurality of openings to conduct fluid from the anterior chamber to the Schlemm's canal;
wherein each of the femtosecond laser pulses comprises a wavelength within a range from 0.4 to 2.5 microns, a fluence level to produce optical breakdown, and a pulse duration in a range from 20 femtoseconds to 300 picoseconds.

US Pat. No. 10,765,558

METHOD AND ARRANGEMENT FOR EYE MEASUREMENTS

PHOTONO OY, Helsinki (FI...

1. An intraocular pressure measurement arrangement for measuring eye pressure, the arrangement comprising:at least one source configured to produce an excitation pressure pulse formed by nonlinear waves in which a principle of superposition does not hold, and transmitted by air to a surface of an eye to generate at least one surface wave for an eye measurement;
a detector configured to detect, based on light reflected off the eye, the at least one surface wave at a distance from the surface for extracting surface wave information; and
one or more processors configured to determine the eye pressure based on said surface wave information.

US Pat. No. 10,765,557

MODULATED PULSED ULTRASONIC POWER DELIVERY SYSTEM AND METHOD

1. A surgical apparatus, comprising:a controller; and
a surgical handpiece configured to receive commands from a controller and apply modulated ultrasonic energy to a surgical area of a patient in a plurality of short burst periods, said short burst periods comprising a first energy burst period followed thereafter by a nonzero second energy burst period,
wherein the energy applied during the first energy burst period is higher than the energy applied during the nonzero second energy burst period,
wherein the first energy burst period is sufficient to induce transient cavitation within the surgical area, and
wherein the first energy burst period is between 1.8 and 3.5 milliseconds.

US Pat. No. 10,765,556

DEVICE AND METHOD FOR CLEARING INTRAOCULAR LENS CONDENSATION DURING VITRECTOMY

1. A device for removing intraocular lens condensation comprising:a handle having proximal and distal ends;
a shaft having a proximal and a distal end wherein the proximal end of the shaft is attached to the distal end of the handle; and
a flexible rubber-like blade having a smooth surface, a teardrop-shaped cross-section, and a proximal and a distal end; wherein the proximal end of the blade is attached to the distal end of the shaft by a hinge; wherein the distal end of the blade is tapered relative to the proximal end of the blade; and
wherein the blade has at least one longitudinal condensation removal edge.

US Pat. No. 10,765,555

OPHTHALMIC SURGICAL FLUID HANDLING CASSETTE

1. An ophthalmic apparatus comprising: a housing defining a cassette receptacle; a sensor arrangement in operative communication with the cassette receptacle; and a cassette configured to operatively engage the cassette receptacle for establishing operative communication between the cassette and the sensor arrangement, the cassette comprising: a cassette body configured to engage the cassette receptacle, wherein the cassette body defines a storage receptacle; a manifold defining an inlet port in fluid flow communication with a fluid pathway; and a storage chamber in selective fluid flow communication with the fluid pathway when the storage chamber is engaged to the storage receptacle of the cassette body; wherein the sensor arrangement is operatively associated with the cassette engaged to the cassette receptacle for transmitting a detection signal to detect: a first state wherein the storage chamber is detached from the storage receptacle, a second state wherein the storage chamber is attached to the storage receptacle and the sensor arrangement detects only air in the storage chamber, and a third state wherein a liquid fills the storage chamber attached to the storage receptacle above a predetermined level.

US Pat. No. 10,765,554

PIERCING NEEDLE-EQUIPPED CANNULA

MANI, INC., Utsunomiya-s...

1. A piercing needle-equipped device, comprising:a cannula adapted to pierce an eyeball and used in ophthalmic operations;
a resin cap having a slit that can be opened in the cannula; and
a piercing needle attached to the cannula, wherein
the piercing needle is comprised of a needle main body on a front end side, a base on a base end side, and a slit piercing part connecting the needle main body and the base wherein the slit piercing part pierces the slit,
a cross-sectional area of the slit piercing part is smaller than a cross-sectional area of a thickest part of the needle main body, and
a cross-sectional shape of the slit piercing part is a flat rectangle.

US Pat. No. 10,765,553

CONTACT LENS MANIPULATOR WITH SUCTION CUP AND SAFETY RELEASE MECHANISM

Craig L. Hershoff, Sunny...

1. A lens manipulator, adapted for handling a contact lens, comprising an over-sleeve with a suction cup comprising one or more discontinuities on a peripheral edge and a lumen therethrough, where the lumen is contiguous with the suction cup, the suction cup having a suction force that is adjustable by positioning an adjustment rod in the lumen to change a volume between the suction cup and the adjustment rod.

US Pat. No. 10,765,552

COOLING CUP APPLICATORS WITH CONTOURED HEADS AND LINER ASSEMBLIES

Zeltiq Aesthetics, Inc., ...

1. An apparatus for treating a subject's tissue, comprising:an applicator configured to cool and affect targeted tissue and including
a base unit including a temperature-controlled cup having a conductive heat-exchanging surface defining a tissue-receiving cavity,
a head removably coupleable to the base unit and including a contoured mouth,
a sealing member being positionable between the head and the base unit to create a vacuum seal therebetween,
latches located on opposite sides of the base unit and movable from unlocked positions to locked positions to pull the head toward the base unit such that the sealing member, which is positioned in a trench of the base unit, is compressed to form the vacuum seal, wherein the trench circumferentially surrounds an entrance of the tissue-receiving cavity, and
a liner assembly having the sealing member and a liner coupled to the sealing member, wherein the liner is configured to extend across the entrance of the tissue receiving cavity when the sealing member is positioned between the head and the base unit;
a controller programmed to command the applicator to draw a vacuum in the tissue-receiving cavity to pull the tissue into thermal contact with the conductive heat-exchanging surface; and
a vacuum source fluidically coupled to the applicator and operable to cause the liner and tissue to be drawn to a bottom of the tissue-receiving cavity to bring the tissue into thermal contact with a portion of the conductive heat-exchanging surface at the bottom of the tissue-receiving cavity.

US Pat. No. 10,765,551

METHOD AND SYSTEM FOR PROVIDING WHOLE BODY CRYOTHERAPY

IMPACT CRYOTHERAPY, INC.,...

1. A method for automatically producing and monitoring a cryotherapy session within a chamber comprising:receiving input for a first temperature for the chamber associated with the cryotherapy session within the chamber;
initiating a pre-cooling session for cooling the chamber to a second temperature which is different than the first temperature, the pre-cooling session comprising automatically activating a first remote control valve and a second remote control valve such that cryogenic gas flows into the chamber, and automatically activating a cryogenic heater when needed to keep the cryogenic gas at a predetermined temperature as the cryogenic gas exits a first nozzle and a second nozzle positioned within the chamber;
determining if the second temperature has been reached in the chamber;
deactivating the first and second remote control valves in response to determining that the second temperature has been reached in the chamber;
initiating the cryotherapy session within the chamber with the cryogenic gas for cooling the chamber to the first temperature, the cryotherapy session comprising automatically activating the second remote control valve, and automatically activating the cryogenic heater when needed to keep the cryogenic gas at a predetermined temperature as the cryogenic gas exits a third nozzle positioned within the chamber;
determining if the first temperature has been reached within the chamber;
determining if a cooling rate for the chamber is being met; and
determining if an overheat condition for the cryogenic heater exists during the pre-cooling session and the cryotherapy session.

US Pat. No. 10,765,550

APPARATUS FOR FIXING BAD POSTURE

1. An apparatus for fixing bad posture comprising:a support rod;
a plurality of length-adjustable straps;
a plurality of strap-attachment points;
the support rod comprising a rod body, a mounting face and a bracing face;
the mounting face and the bracing face being laterally positioned along the rod body;
the mounting face and the bracing face being positioned opposite to each other about the rod body;
the plurality of strap-attachment points being serially distributed along the rod body;
the rod body comprising a pair of bars;
the rod body being of V-shaped by the pair of bars being connected with each other and being oriented with each other via an acute angle, an obtuse angle or a right angle;
each of the plurality of strap-attachment points comprising a pair of slots, a corresponding slot among the pair of slots traversing through a corresponding bar among the pair of bars from the mounting face to the bracing face, the pair of slots being positioned offset from each other, each of the pair of slots being oriented parallel to a length of the support rod;
each of the plurality of length-adjustable straps being engaged to a corresponding point from a plurality of selected points, wherein the plurality of selected points are from the plurality of strap-attachment points;
each of plurality of length-adjustable straps traversing through each of the pair of slots of the corresponding point;
each of the plurality of length-adjustable straps comprising a first end portion, a central portion, a second end portion and an adjustable fastener;
the central portion being positioned in between the first end portion and the second end portion; and
the first end portion and the second end portion being attached to each other by the adjustable fastener.

US Pat. No. 10,765,549

FLEXIBLE FOOT ABDUCTION APPARATUS

1. A flexible foot abduction apparatus allowing vertical and horizontal movement comprising:an elongated member comprising a first end and a second end;
a left plate;
the left plate selectively attachable to the first end;
a right plate;
the right plate selectively attachable to the second end;
the elongated member having a first portion and a second portion;
the elongated member having a middle portion between the first portion and second portion;
the middle portion above the first portion and the second portion;
wherein the middle portion is configured to allow a user to move the first end in both a horizontal plane and a vertical plane relative to the second end;
the elongated member having an original shape;
the elongated member bendable to a second shape when a force is applied by the user;
the elongated member made of a shape memory material wherein the elongated member reforms to the original shape upon removal of the force.

US Pat. No. 10,765,548

KNEE JOINT ORTHOSIS

Yun Luo, Shanghai (CN)

1. A knee joint protecting device, comprising:a thigh frame wearable on a thigh of a lower limb of a user and a shank frame wearable on a shank of the lower limb, the thigh frame is connected to the shank frame and rotatable around a first axis to perform a first rotation, at a connection position, about the shank frame within a first position and a second position;
wherein in the first position of the thigh frame, the knee joint protecting device is configured to fit the lower limb of the user in a standing posture; and wherein the thigh frame is configured to perform a second rotation about the shank frame, an included angle of the first axis and a rotation plane of the second rotation is within a range of 0 to 15°;
a connection structure set between the thigh frame and the shank frame, the connection structure comprises an adjustment mechanism and a connection hinge, which are connected with each other;
wherein the thigh frame performs the first rotation by the adjustment mechanism and performs the second rotation by the connection hinge;
wherein the connection position is on the adjustment mechanism;
wherein the adjustment mechanism comprises a groove plate and a sliding block, one of said groove plate and said sliding block is connected to the thigh frame by the connection hinge, and other of said groove plate and said sliding block is fixed on the shank frame;
wherein the thigh frame is configured to stretch outwardly using the connection hinge in response to the thigh frame turning to the second position from the first position;
and wherein the thigh frame is configured to shrink inwardly using the connection hinge in response to the thigh frame turning to the first position from the second position;
wherein the connection hinge comprises a first hinge part and a second hinge part, which rotate about each other on a first rotation plane;
wherein the second hinge part is rotatably connected to the adjustment mechanism, the second hinge part and the adjustment mechanism rotate about each other on a second rotation plane; and
wherein in the first position of the thigh frame, an included angle of the first rotation plane and the second rotation plane is 90°±40°.

US Pat. No. 10,765,547

WRIST BRACE FOR PROTECTING INTEGRITY OF THE CARPAL TUNNEL

Myers Design LLC, Battle...

13. A wrist brace apparatus for ovating the carpal tunnel of a user having a wrist and a hand, the hand having a radial side associated with a thumb thereof and an ulnar side associated with a pinky finger thereof, said apparatus comprising:a wrist strap configured to encircle the wrist of a user,
an ulnar guyline operative to exert a tensile force along an ulnar vector in-between the user's pinky finger and said wrist strap, said ulnar guyline having an ulnar anchor directly attached to said wrist strap, said ulnar anchor comprising an elongated strip of a flexible material fitted with a hook-and-loop fastener system, said ulnar guyline including a pinky tension element extending from said ulnar anchor to a distal end, said pinky tension element including a pinky hook attached to said distal end of said pinky tension element, said pinky tension element being fabricated from a monolithic elastic cord with said pinky hook comprising an eye formed integrally from said elastic cord,
a radial guyline operative to exert a tensile force along a radial vector in-between the user's thumb and said wrist strap, said radial guyline having a radial anchor directly attached to said wrist strap, said radial anchor comprising an elongated strip of a flexible material fitted with a hook-and-loop fastener system, said radial guyline including a thumb tension element extending from said radial anchor to a distal end, said thumb tension element including a thumb hook attached to said distal end of said thumb tension element, said thumb tension element being fabricated from a monolithic elastic cord with said thumb hook comprising an eye formed integrally from said elastic cord, and
said pinky tension element and said thumb tension element overlapping one another at a cross-over point spaced apart from said wrist strap.

US Pat. No. 10,765,546

MODIFIED APPARATUS FOR FOOD EXTRACTION AND OBESITY TREATMENT

Ethicon, Inc., Somervill...

1. A device comprising:a) a channeled collection element having a longitudinal axis, a distal end and a proximal end, wherein the collection element further comprises a separate distinct lumen sealed at its proximal end and that runs substantially parallel to the longitudinal axis and for substantially the full length of the channeled collection element;
b) at least one slot formed in the channeled collection element, said slot parallel to the longitudinal axis of the channeled collection element and sized to permit entrance into the channeled collection element of solubilized sugars or dispersed starches;
c) a port or a port/valve assembly in fluid communication with the distal end of the channeled collection element;
d) a shaping element for insertion into said separate distinct lumen;
e) at least two inflation elements in fluid communication with said separate distinct lumen; and
f) a plug for sealing said separate distinct lumen at its distal end while the shaping element is contained within said separate distinct lumen.

US Pat. No. 10,765,545

SUTURE ESOPHAGEAL STENT INTRODUCER

Cook Medical Technologies...

1. A stent delivery system, comprising,an elongate shaft including a proximal portion, a distal portion, at least one lumen extending at least partially therethrough, and a stent receiving portion on the distal portion of the elongate shaft;
a stent positioned on the stent receiving portion of the elongate shaft, the stent having a first configuration and a second configuration;
a proximal constraining arrangement engaged with a proximal end of the stent, the proximal constraining arrangement comprising a first proximal constraining member having a proximal portion, a second proximal portion, and a distal portion and a second proximal constraining member having a first proximal portion and a distal portion, the distal portion of the first proximal constraining member engaged with a first proximal portion of the stent and the distal portion of the second proximal constraining member engaged with a second proximal portion of the stent;
a distal constraining arrangement engaged with a distal end of the stent, the distal constraining arrangement comprising a first distal constraining member having a proximal portion, a second proximal portion and a distal portion, and a second distal constraining member having a proximal portion and a distal portion, the distal portion of the first distal constraining member engaged with a first distal portion of the stent and the distal portion of the second proximal constraining member engaged with a second distal portion of the stent;
a handle assembly comprising a first shuttle operably connected to the proximal constraining arrangement and a second shuttle operably connected to the distal constraining arrangement; and,
a brake assembly positioned within the handle assembly, the proximal constraining arrangement being coupled to the brake assembly;
wherein the proximal constraining arrangement and the distal constraining arrangement applies an axial mechanical force to at least a portion of the stent in the first configuration.

US Pat. No. 10,765,544

PUSH AND PULL MEDICAL DEVICE DELIVERY SYSTEM

1. A system for delivery of a medical device, said system comprising:a first member including an elongated first portion and a guidewire lumen, wherein the first member is configured to extend outside of a body from a first percutaneous access site;
a second member separate from the first member and configured to be inserted into a body of a patient separately from the first member, the second member including an elongated second portion, wherein the second member is configured to extend outside the body from a second percutaneous access site, the second portion defining a a bore and the second percutaneous access site being different from the first percutaneous access site;
a constraining member; and
a medical device disposed about an exterior of the first portion of the first member and releasably retained in a delivery configuration about the first portion by the constraining member for endoluminal delivery of the medical device toward a treatment site in a human vessel,
wherein the first and second members allow for positioning of the medical device at the treatment site by manipulation of the first portion and the second portion from outside of the body, and wherein the second portion is configured to receive the medical device and the constraining member within the bore of the second portion while the medical device is disposed about the first portion of the first member in the delivery configuration such that the second portion is releasably coupleable to the medical device, wherein an end of one of the first and second portions is configured to be received within an end of the other first and second end portions.

US Pat. No. 10,765,543

DEPLOYMENT HANDLE FOR A MEDICAL DEVICE DEPLOYMENT SYSTEM

1. A medical device deployment handle comprising:a first portion suitable for gripping by a user;
a first actuation member operable to be actuated relative to the first portion;
an actuating mechanism operably coupled to the first actuation member;
a second actuation member operable to be actuated relative to the first portion and relative to the first actuation member; and
a cover operably coupled to the first actuation member via the actuating mechanism and transitionable between a first position and a second position such that the first actuation member is actuatable to cause the cover to transition from the first position to the second position, wherein in the first position the cover restricts access to the second actuation member, and wherein in the second position the second actuation member is accessible, wherein the cover translates along a longitudinal axis of the handle when transitioning from the first position to the second position.

US Pat. No. 10,765,542

METHODS AND APPARATUS FOR LUMINAL STENTING

COVIDIEN LP, Mansfield, ...

1. A flow-directing device implantable across an aneurysm in a blood vessel of a patient, the flow-directing device comprising:a proximal end;
a distal end;
a length extending between the proximal end and the distal end;
a lumen extending the length; and
a plurality of strands braided together, the strands formed of materials comprising a cobalt-nickel alloy;
wherein the flow-directing device has a porosity between the strands configured to direct blood flow away from an aneurysm and to allow blood flow to branch vessels when placed in a blood vessel;
wherein the flow-directing device is self-expandable from a compressed state to an expanded state;
wherein the length of the flow-directing device in the expanded state is shorter than the length of the flow-directing device in the compressed state;
wherein a diameter of each of the plurality of strands is between about 0.0005 inches and 0.0020 inches;
wherein each of the plurality of strands comprises an inner surface and an outer surface, the outer surfaces comprising between about 20% and about 50% of a total circumferential area of the flow-directing device in the expanded state; and
wherein a linear density of the plurality of strands is at least 74.04 picks per inch along the length of the flow-directing device in the expanded state.

US Pat. No. 10,765,541

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

Aortic Innovations, LLC, ...

1. An endograft device for endovascular repair of aortic aneurysms, comprising:a first endovascular prosthetic component comprising:
an expandable stent frame; and
a sealing cuff protruding from a lumen of the first prosthetic component,
wherein blood flowing through the first prosthetic component is allowed to flow through at least one of the brachiocephalic artery, the left common carotid artery, and left subclavian artery when the endograft device has been implanted,
a second endovascular prosthetic component secured to the first prosthetic component and comprising an expandable stent frame,
wherein the first prosthetic component is configured to be placed into engagement within an arch of the patient's aorta,
wherein the second prosthetic component is configured to be placed within the ascending aorta of a patient,
wherein a portion of the second prosthetic component is configured to be received within the sealing cuff by an interference fit between the portion of the second prosthetic component and the sealing cuff,
wherein the sealing cuff is covered with a graft material and the portion of the second prosthetic component received within the sealing cuff is covered with a graft material to cooperatively seal the first prosthetic component and the second prosthetic component by overlapping engagement of the graft material of the sealing cuff and the graft material of the portion of the second prosthetic component,
wherein the sealing cuff is configured for being placed proximal of the brachiocephalic artery,
wherein the second prosthetic component is configured to be secured to the first prosthetic component within the sealing cuff.

US Pat. No. 10,765,540

STENT AND STENT DELIVERY DEVICE

Terumo Corporation, Toky...

1. An implant device comprising:a tubular first layer with a space therethrough; said tubular first layer having a first braid with a first porosity and being entirely composed of a single shape memory metal wire; and,
a tubular second layer located within said space within said tubular first layer; said tubular second layer having a second braid with a second porosity that is lower than said first porosity and being composed of shape memory metal wire;
wherein said tubular second layer is connected to said tubular first layer at one or more locations so as to allow for radial expansion and delivery at about the same time.

US Pat. No. 10,765,539

STENT GRAFT DEVICE WITH ANCHORING MEMBERS HAVING ADJUSTABLE GEOMETRIES

1. A stent graft device comprising:an expandable frame configured to transition from a collapsed configuration to an expanded configuration;
a covering extending over said expandable frame; and
an anchoring member coupled to said expandable frame by a plurality of coupling members positioned on the exterior surface of said expandable frame and configured to extend along a length of said expandable frame in both the collapsed configuration to the expanded configuration, the anchoring member being configured to adopt a shape when the expandable frame is in the expanded configuration, the shape defining a removal path,
wherein said shape which said anchoring member adopts includes at least one of a serpentine or a cork-screw configuration that forms raised portions that extend outwardly and angularly from the expandable frame between successive coupling members and wherein said anchoring member is configured to be removed along the removal path while the expandable frame is in the expanded configuration with minimal trauma to any tissue growth over said anchoring member, wherein the anchoring member and the removal path are positioned entirely exterior of the covering.

US Pat. No. 10,765,537

TUNABLE ACTUATOR JOINT MODULES HAVING ENERGY RECOVERING QUASI-PASSIVE ELASTIC ACTUATORS FOR USE WITHIN A ROBOTIC SYSTEM

Sarcos Corp., Salt Lake ...

1. A robotic system for a robotic limb configured to recover energy for minimizing power consumption of the robotic system, comprising:a plurality of support members; and
at least one tunable actuator joint module rotatably coupling two of the plurality of support members, the at least one tunable actuator joint module defining a joint of the robotic system rotatable about an axis of rotation, and comprising:
a primary actuator operable to apply a primary torque to cause actuation of the joint; and
a quasi-passive elastic actuator comprising an elastic component dynamically tunable to a joint stiffness value, the quasi-passive elastic actuator operable to store energy upon a first rotation of the joint, and to release energy upon a second rotation of the joint to apply an augmented torque to the joint that combines with the primary torque from the primary actuator to assist rotation of the joint,
wherein the quasi-passive elastic actuator comprises a rotary pneumatic actuator, and the elastic component comprises a housing that is gas pressure charged to a selected gas pressure to define a predefined joint stiffness value, a first vane device coupled to a first support member and a second vane device coupled to a second support member, the first vane device and the second vane device defining a compression chamber and an expansion chamber within the housing, and
wherein the first vane device is rotatable relative to the second vane device about the axis of rotation, wherein upon a first rotation gas is compressed in the compression chamber between the first vane device and the second vane device to store energy, such that, upon a second rotation, gas is expanded in the compression chamber to release the stored energy to apply the augmented torque to assist in actuation of the joint.

US Pat. No. 10,765,536

CATAPULT ANKLE AND RELATED METHODS

Rehabilitation Institute ...

1. An ankle prosthesis for operation in a swing phase and in a stance phase, comprising:a motor, wherein the motor is configured to:
store energy with a first spring during the swing phase; and
plantarflex the ankle prosthesis during a push off portion of the stance phase;
one or more sensors; and
a controller configured to:
determine whether the ankle prosthesis is in the swing phase or the stance phase based on information from the one or more sensors;
control the motor to dorsiflex the ankle prosthesis based on a start of the swing phase; and
control a clutch coupled to the motor to engage during the push off portion of the stance phase, to thereby cause the motor to plantarflex the ankle prosthesis in cooperation with the first spring during the push off portion of the stance phase;
wherein the first spring is configured to store energy in a charging disk during the swing phase, and to release the stored energy from the charging disk to plantarflex the ankle prosthesis during the push off portion of the stance phase.

US Pat. No. 10,765,534

SHOULDER ARTHROPLASTY SYSTEM METHOD WITH COMBINATION HUMERAL SIZER, TRIAL, AND GUIDE

DePuy Synthes Products, I...

1. A method of implanting a humeral component comprising:accessing a humerus;
resecting a head portion of the humerus to form a resected surface;
selecting a first combination sizer and guide device having an outer surface sized complementary to a desired implant head size;
positioning the selected first combination sizer and guide device on the resected surface;
guiding placement of a guide pin in the humerus with the first combination sizer and guide device positioned on the resected bone;
guiding a reamer with the placed guide pin to form a reamed cavity in the humerus;
positioning an anchoring portion of a humeral implant base portion in the reamed cavity;
positioning the first combination sizer and guide device on the positioned base portion;
removing the first combination sizer and guide device from the positioned base portion; and
positioning an implant head on the positioned base portion.