US Pat. No. 10,426,998

PORTABLE DEVICE FOR MOVEMENT AND RESISTANCE TRAINING OF THE LOWER EXTREMITIES

ARIZONA BOARD OF REGENTS ...

1. A device for movement and resistance training of a lower extremity, said device being capable of electronically tracking use and level of resistance for a user, said device comprising:(a) a support base (10);
(b) a footpad (16), having an upper end (44) and a lower end (46), attached to the support base (10), wherein the footpad (16) has a curved shape to ensure full contact between a foot (32) of the user and the footpad (16) thus allowing the foot (32) of the user to apply an equal distribution of pressure to the footpad (16), wherein the curved shape of the footpad (16) is convex from the upper end (44) of the footpad (16) to the lower end (46) of the footpad (16);
(c) a resistance mechanism, attached to the footpad (16), to resist pressure applied by the foot (32) of the user to the footpad (16), wherein the resistance mechanism comprises:
(i) a curved arm (18) having a first end and a second end, wherein the first end is attached near the upper end (44) of the footpad (16), and wherein the curved arm (18) curves toward the lower end (46) of the footpad (16);
(ii) a spring hinge mounted to a bracket (22) secured to the support base (10), wherein the second end of the curved arm is attached to the bracket (22) via the spring hinge, wherein a resistance of the spring hinge determines a resistance of the footpad (16), wherein the bracket (22) provides a pivot point configured such that the foot (32) of the user moves about pivot point wherein the pivot point is between the upper end (44) and the lower end (46) of the footpad (16); and
(iii) a brace (36) directly coupling the curved arm (18) to the support base (10), wherein a placement of the brace along the curved arm (18) determines a range of motion of the footpad (16),
wherein the resistance mechanism provides an equal distribution of resistance to the footpad (16) for a more effective training of the lower extremity; and
(d) one or more sensors (24, 26) attached to the footpad (16), wherein the one or more sensors (24,26) are configured to detect an amount of pressure applied by the foot (32) of the user and a number of presses by the foot (32) of the user.

US Pat. No. 10,426,997

WEARABLE EXERCISE APPARATUSES

Jeffrey D. Stewart

1. A wearable footwear apparatus comprising:a step-up mechanism having a V-shaped expanded configuration and a compressed configuration, the step-up mechanism including
a self-expanding assembly for moving the set-up mechanism to the V-shaped expanded configuration, and
a locking device configured to keep the step-up mechanism in the V-shaped expanded configuration while a user steps onto the step-up mechanism, wherein the locking device is configured to unlock to allow the step-up mechanism in the V-shaped expanded configuration to begin collapsing after the step-up mechanism supports substantially all of the user's mass and in response to the user's body weight being transferred from a first section of the step-up mechanism to a second section of the step-up mechanism.

US Pat. No. 10,426,996

REHABILITATION MACHINE AND APPARATUS

1. An exercise apparatus, comprising:a main support column;
a first arm with a proximal end and a distal end, hingedly connected at a first height to the main support column at the proximal end;
a second arm with a proximal end and a distal end, hingedly connected at a second height to the main support column at the proximal end, wherein the second height is greater than the first height;
a first rotary mechanism located at the distal end of the first arm, said first rotary mechanism adapted to move a set of pedals in a rotary fashion; and
a second rotary mechanism located at the distal end of the second arm, said second rotary mechanism adapted to move a set of handles in a rotary fashion.

US Pat. No. 10,426,995

ARM EXERCISE ASSEMBLIES

1. An arm exercise assembly, comprising:a frame shaped and sized to receive a human forearm;
a piston coupled to the frame;
a bracket pivotably coupled to the frame;
a wheel coupled to the piston and pivotably coupled to the bracket;
two locks extending radially through the wheel toward inner portions of the wheel; and
a handle pivotably coupled to the wheel, wherein the handle is capable of being abutted against one or both of the two locks.

US Pat. No. 10,426,994

EXERCISE DEVICE HANDLE AND METHOD OF USING SAME

TOTAL GYM GLOBAL CORP., ...

1. An exercise device handle for an exercise device, comprising:a handle tube including at least one straight portion, at least one bent portion, and opposite ends;
a stand-up paddle boarding (SUP) grip at both of the opposite ends of the handle tube, the SUP grip is at least twice as wide as the at least one straight portion, is bowed outward in a central portion, and is configured to be gripped by hands of a user in the same manner as gripping a grip on the end of a SUP paddle or a grip on the end of a canoe paddle, the SUP grip extending primarily in a Z direction, the at least one straight portion extending primarily in an X direction, and the at least one bent portion extending primarily in the X and Y directions, the at least one straight portion and at least one bent portion includes a central straight base portion;
an incurved portion that is concave up in a Y direction and transitions into an increased width portion that increases gradually in width in a Z direction, progressing from the incurved portion to the SUP grip.

US Pat. No. 10,426,993

TRACK-MOUNTED LEVER RELEASE EXERCISE RACK ACCESSORY MOUNT

Arsenal Strength LLC, Kn...

1. A quick disconnect exercise rack accessory apparatus comprising:an accessory for an exercise rack having a use portion and a mounting plate fixedly mounted to an end of the use portion;
an accessory carrier having a first side configured to mount to the exercise rack and a second side configured to connect to the accessory;
a slot formed in the second side of the accessory carrier having an open end, an inner section and an outer section in communication with the inner section;
wherein the accessory is removably mounted to the accessory carrier by sliding the mounting plate into the slot via the open end such that the mounting plate is located within the inner section of the slot and the accessory extends through the outer section of the slot; a safety stop disposed on the accessory carrier proximate the slot and being configured to move between a second position and a first position, wherein the safety stop is in the second position and the mounting plate is located within the slot, the mounting plate is configured to slide out of the slot freely, and wherein, when the safety stop is in the first position and the mounting plate is located within the slot, the safety stop engages the mounting plate and prevents the mounting plate from sliding out of the slot.

US Pat. No. 10,426,992

BARBELL MASSAGE APPARATUS

1. In combination with a barbell having a cylindrical surface, wherein an improvement comprises:a barbell massage apparatus including:
a spherical member defining an exterior massage-contact surface;
at least two arms extending away from the exterior massage-contact surface that respectively flank two sides of the cylindrical surface of the barbell and retain the barbell massage apparatus thereon, the at least two arms at least partially defining a U-shaped channel with the cylindrical surface of the barbell disposed therein; and
a spherical member sleeve sized and shaped to removably cover at least a portion of the exterior massage-contact surface, the spherical member sleeve defining a second exterior massage-contact surface;
wherein the spherical member defines at least one groove; and the spherical member sleeve includes at least one lip dimensioned to matingly fasten to the at least one groove so as to secure the spherical member sleeve on the spherical member, the second exterior massage-contact surface includes a plurality of massage projections that extends outwardly and away from the spherical member when the spherical member sleeve is secured to the spherical member through the at least one lip and the at least one groove.

US Pat. No. 10,426,991

EXERCISE DEVICE

1. An exercise device, comprising:a straight track comprising a first end and a second end;
a track carriage disposed on and movable in a first plane along said track, said track carriage including a handle on each of two sides of said track carriage extending widthwise with respect to said track;
a resistance system selectively engageable with said track carriage to provide variable resistance or assistance to movement of said track carriage along said track;
a platform having a support surface adapted to support a user of the device in seated and kneeling positions, wherein said platform is rotatably secured to said track carriage such that said platform rotates left and right relative to said track carriage, in a second plane substantially parallel to the first plane, about an axis that is perpendicular to said track;
a bracket coupled to the second end of said track; and
a vertical support including a plurality of support positions each adapted to support said bracket for selectively varying a height of the bracket and the second end of said track relative to the first end of said track.

US Pat. No. 10,426,990

CONVERTIBLE BENCH AND UPRIGHT STABILIZING SUPPORT

HOIST FITNESS SYSTEMS, IN...

1. An exercise machine, comprising:a frame;
an arm exercise assembly that is vertically positionable on the frame; and
a workout station connected to the frame, the workout station comprising:
a seat,
a stabilizing support,
an extendable post connected to the stabilizing support, and
a pivot adjustment mechanism connected to the extendable post,
wherein the pivot adjustment mechanism pivots the extendable post forwards and backwards such that the position of the stabilizing support is configured to be adjusted forwards and backwards, and
wherein the extendable post is configured to be extended or retracted to adjust the height of the stabilizing support,
and wherein the seat is connected to the extendable post such that the seat and the extendable post pivot together as a unit when the pivot adjustment mechanism is adjusted.

US Pat. No. 10,426,989

CABLE SYSTEM INCORPORATED INTO A TREADMILL

1. A treadmill, comprising;an opening formed in a surface running side of a running deck;
a resistance mechanism including a flywheel incorporated into the running deck;
a sensor connected to the resistance mechanism, the sensor configured to determine one or more of a number of revolutions and a number of partial revolutions of the flywheel;
a cable threaded through the opening where the cable comprises a resistance end connected to the resistance mechanism and a pull end accessible through the running deck;
a display connected to the treadmill; and
a processor in communication with the display and configured to perform:
measuring aerobic calories burned during aerobic exercise using the running deck;
measuring pulling anaerobic calories burned during pulling anaerobic exercise using the resistance mechanism and using the sensor to provide information to the processor about energy expended during pulling anaerobic exercise using the resistance mechanism using one or more of the number of revolutions and the number of partial revolutions of the flywheel; and
displaying the aerobic calories burned and the anaerobic calories burned.

US Pat. No. 10,426,988

RESISTANCE EXERCISE DEVICE

1. A resistance exercise device that is held in at least one hand of a user and whirled in use, comprising:an elongated handle having a first handle end and a second handle end;
an elongated element having a first end, a second end, and defining a longitudinal axis extending through the first end and the second end, at least a portion of the elongated element proximate the first end being flexible;
a coupling connecting the elongated element at or near the first end to the elongated handle at or near the first handle end; and
a plurality of resistance fins attached to the elongated element, the resistance fins disposed around and along a portion of the elongated element and oriented in an outwardly direction from the longitudinal axis, the elongated element and attached resistance fins being at least generally symmetrical along the longitudinal axis,
whereby when whirled in use, the elongated element and the attached resistance fins prevent rotation about the longitudinal axis and produce a substantially continuous resistance exercise.

US Pat. No. 10,426,987

FIREFIGHTING FOAM GENERATOR

1. A firefighting foam generator including:a receptacle for receiving a flow of liquid;
a gas supply for supplying pressurized gas into the flow of liquid to create foam, the gas supply comprising a tube which extends into the receptacle transverse to the flow of liquid, the tube includes a plurality of gas outlets, and
a first and second turbulence creator, each for creating turbulence in the receptacle,
the first turbulence creator including a baffle positioned within the receptacle at a first location spaced apart from and upstream of the tube, relative to the flow of liquid, and
the second turbulence creator including a baffle positioned within the receptacle at a second location downstream of the tube, relative to the flow of liquid,
each turbulence creator comprising an edge, positioned transverse to the flow of liquid which extends between and contacts the receptacle at a first position and a second position.

US Pat. No. 10,426,986

BRACKET FOR INSTALLATION OF A FIRE PROTECTION SPRINKLER

The Reliable Automatic Sp...

1. A support bracket for use in installing a sprinkler fitting for a fire protection sprinkler in a building having a ceiling that includes a structure, the support bracket comprising:(A) a support beam configured to extend over a space within the structure of the ceiling;
(B) at least one end bracket provided at a first end of the support beam, and configured to attach the support bracket to the structure of the ceiling, the at least one end bracket comprising:
(a) an upper body;
(b) a lower grip including:
(i) a first leg;
(ii) a second leg that is adjacent to the first leg; and
(iii) a third leg that is adjacent to the second leg, the second leg being provided between the first leg and the third leg, wherein a width of the second leg is roughly equal to or greater than a combined width of the first leg and the third leg; and
(c) a connecting portion that joins the upper body and the lower grip; and
(C) a center bracket supported by the support beam, and configured to receive at least a portion of the sprinkler fitting, the center bracket including:
(a) a body that defines an opening to receive the portion of the sprinkler fitting;
(b) a closure assembly including:
(i) a first pin mounted in the body and having a first pin axis;
(ii) a closure member having a first end rotatably connected to the body by the first pin, and a second end that includes a handle, the closure member being rotatable about the first pin axis relative to the body, and being movable between an open position and a closed position, wherein, when the closure member is in the closed position and the portion of the sprinkler fitting is received in the opening of the body, the closure assembly presses the portion of the sprinkler fitting against at least one of the body and the support beam and urges the center bracket against the support beam to maintain the center bracket stationary relative to the support beam;
(iii) a second pin mounted in the body at a distance from the first pin, the second pin having a second pin axis; and
(iv) a lever rotatably connected to the body by the second pin, and positioned relative to the closure member such that, when the closure member moves from the open position to the closed position, the closure member contacts and rotates the lever to cause the lever to press the portion of the sprinkler fitting against the at least one of the body and the support beam; and
(c) a lock inserted into the body, spaced from the first pin and the second pin, and configured to engage the closure member when the closure member moves in a direction from the open position toward the closed position, and to engage the closure member to prevent the closure member from returning from the closed position to the open position.

US Pat. No. 10,426,985

SPRINKLER DROP BRACKET FOR INTERSECTING DOWNLIGHT

Anvil International, LLC,...

7. A bracket assembly comprising:a main body, the main body comprising a first set of seating members extending downwards from the main body; and
a support arm extending laterally outward from the main body, the support arm comprising:
a shaft oriented perpendicular to the main body, and
a second set of seating members extending downwards from the shaft; and
wherein the main body defines a central opening, and wherein the central opening includes a laterally extending irregularity and is snail-shaped.

US Pat. No. 10,426,984

SPRINKLER ASSEMBLY

The Viking Corporation, ...

1. A sprinkler assembly comprising:a body including a passageway, an inlet opening, a discharge opening, and a central axis extending through said discharge opening;
a support extending from said body at a first fixed location downstream relative to the discharge opening of the body;
a closure device releasably positioned at said discharge opening to close said passageway;
a heat responsive trigger mounted to releasably retain said closure device at said discharge opening of said body; and
a flow shaper non-movably secured to said support at a second fixed location downstream relative to the discharge opening of the body, said flow shaper including a transverse wall portion intersecting said central axis, said transverse wall portion being rectangular with a pair of longer side edges and a pair of relatively shorter end edges a pair of laterally spaced sidewalls integrally formed with and extending from said longer side edges of said transverse wall portion toward said body and a pair of mounting base portions integrally formed with and extending from said pair of sidewalls and connected to the support for supporting the flow shaper to said support.

US Pat. No. 10,426,983

FIRE SPRINKLER SYSTEM HAVING COMBINED DETECTION AND DISTRIBUTION PIPING

1. A fire sprinkler system in communication with a source of fire extinguishing fluid, the fire sprinkler system comprising:a piping system having at least one dual-use pipe providing both an air opening and a fire extinguishing fluid conveying outlet, the at least one dual-use pipe having at least one air conveying opening;
a blower fluidly connected to the at least one dual-use pipe to provide a substantially continuous flow of ambient air through the at least one dual-use pipe, the ambient air entering or exiting the at least one dual-use pipe via the at least one air conveying opening;
a control unit fluidly connected to the at least one dual-use pipe to measure the flow of the ambient air therethrough, the control unit operable to detect a difference between a measured airflow rate value of the ambient air through the at least one dual-use pipe and a baseline airflow rate value of the ambient air, a fire condition being detected by the control unit when a difference between the baseline airflow rate and the measured airflow rate exceeds a predetermined delta value;
a selective flow valve mounted in sealed engagement about the air opening, the ambient air flowing freely through the selective flow valve into or out of the at least one dual-use pipe upon the difference between the baseline and measured airflow rate values not exceeding the predetermined delta value;
a valve disposed between the source of the fire extinguishing fluid and the at least one dual-use pipe, the valve being in communication with the control unit and operable to displace between an open position to fill the at least one dual-use pipe with the fire extinguishing fluid upon detection of the fire condition, and a closed position; and
at least one automatic sprinkler fluidly connected to the at least one dual-use pipe for ejecting the fire extinguishing fluid from the at least one dual-use pipe upon detection of the fire condition, said at least one automatic sprinkler having a frangible component, the frangible component breaking to create a supplemental airflow path through the at least one automatic sprinkler between the at least one dual-use pipe and surrounding ambient air, the supplemental airflow path increasing the difference between the baseline and measured flow rate values beyond the predetermined delta value, and to eject the fire extinguishing fluid from said at least one automatic sprinkler upon an increase in temperature of the ambient air being indicative of the fire condition.

US Pat. No. 10,426,982

LINE SECURING DEVICE

1. A securing device for securing a person, the securing device comprising:a support structure;
a rope drum, on which a safety rope, to which the person is attachable, is reelable;
an axle element, which is attached in a non-rotational manner to the rope drum and rotatably to the support structure, such that, by the axle element, the rope drum is supported rotatably to the support structure;
a lever
attached pivotably to the support structure at a deflection point,
wherein the lever has a blocking section, which is configured
such that, in a blocking position of the lever, the blocking section is coupled to the rope drum in order to disable a rotation of the rope drum, and
such that, in a releasing position of the lever, the blocking section is decoupled from the rope drum and the rope drum is rotatable,
wherein the lever has a first thread section, which is spaced apart from the blocking section;
wherein the axle element has a second thread section,
wherein the first thread section is coupled to the second thread section, such that, upon rotation of the axle element, due to the rotation of the rope drum, the first thread section is shifted along the axle element, such that, due to the shifting of the first thread section, a rotation of the lever around the deflection point and an adjustment between the blocking position and the releasing position of the lever are effected.

US Pat. No. 10,426,981

DEPLOYMENT UNIT FOR AN AVALANCHE RESCUE SYSTEM, USE OF AN ACTUATING HANDLE, AND DEPLOYMENT DEVICE

Matthias Werz, Engstinge...

1. A deployment unit for an avalanche rescue system configured with function unit, the deployment unit comprising:an actuating handle having a coupling piece connected thereto;
a coupling element that can be connected to the function unit of the avalanche rescue system; and
a handle holder;
wherein the coupling piece and the coupling element are displaceable together along a common longitudinal axis in a coupling channel in the handle holder and are held in a coupling connection by the coupling channel; and
wherein the coupling connection is releasable when the coupling piece, the coupling element or both exit from the coupling channel.

US Pat. No. 10,426,978

ULTRASONIC TREATMENT APPARATUS

OLYMPUS CORPORATION, Tok...

1. An ultrasonic treatment apparatus comprising:a high frequency supply section configured to supply a high frequency electric power;
a probe main body extending from a proximal direction toward a distal direction along a longitudinal axis, the probe main body receiving the high frequency electric power supplied from the high frequency supply section, the probe main body being configured to transmit an ultrasonic vibration from the proximal direction toward the distal direction such that a longitudinal vibration is generated in a vibrating direction parallel to the longitudinal axis;
a distal treatment section positioned on a distal direction side with respect to a most distal node position positioned most distally among node positions of the longitudinal vibration in the probe main body, the distal treatment section being configured to apply the ultrasonic vibration transmitted through the probe main body to a treated object, and the high frequency electric power being supplied to the distal treatment section through the probe main body such that the distal treatment section is a first electrode;
a jaw that is openable and closable relative to the distal treatment section, the high frequency electric power being supplied to the jaw from the high frequency supply section such that the jaw is a second electrode different in potential from the first electrode in a position facing the first electrode, a high frequency current flowing between the second electrode and the first electrode when the distal treatment section is the first electrode and the jaw is the second electrode;
a sheath through which the probe main body is inserted in a state where the distal treatment section is projected toward the distal direction, the sheath forming an electric path of the high frequency electric power that is supplied to the jaw, the sheath being spaced from the probe main body;
a probe side facing surface provided in a position facing the jaw in a surface of the distal treatment section, the probe side facing surface being configured to grip the treated object between the probe side facing surface and the jaw, frictional heat being generated on the probe side facing surface by the longitudinal vibration of the probe main body due to the ultrasonic vibration, and the high frequency current, which flows between the first electrode and the second electrode, passing through the probe side facing surface; and
a coating portion made of a material having electrically insulating properties and having a higher heat resistance than the probe main body, the coating portion coating the surface of the distal treatment section except for the probe side facing surface, the high frequency current that flows between the first electrode and the second electrode being prevented from passing through the coating portion due to the electrically insulating properties of the coating portion such that a current density of the high frequency current, which passes through the probe side facing surface, is increased, wherein:
a first part that is coated with the coating portion in the surface of the distal treatment section includes a proximal-region surface located on a proximal direction side with respect to the probe side facing surface,
the coating portion directly adheres to the surface of the distal treatment section in the proximal-region surface, and
the proximal-region surface includes a completely-coated region, the completely-coated region being provided at least in a second part that is located inside the sheath, the coating portion coating an entire-periphery of the surface of the distal treatment section around the longitudinal axis in the completely-coated region, wherein the jaw includes a jaw inclined surface which faces the probe side facing surface and which is inclined relative to an opening and closing direction of the jaw, and a third part of the probe side facing surface which faces the jaw inclined surface is not covered with the coating portion.

US Pat. No. 10,426,977

MOVING FLOOR FOR RADIOTHERAPY SYSTEM WITH CANTILEVER GANTRY ASSEMBLY

VARIAN MEDICAL SYSTEMS PA...

1. A radiotherapy system comprising:an accelerator configured to provide a particle beam with an initial energy;
a support member operable to be coupled to an external supporting structure;
a cantilever gantry assembly coupled to said accelerator and said support member and comprising a gantry beamline configured to transport said particle beam, wherein said cantilever gantry assembly is configured to be supported by said support member in a cantilevered manner;
a beam nozzle coupled to said cantilever gantry assembly and configured to irradiate said particle beam onto a target object;
a moving floor configured to:
support a person;
move in a lateral plane in synchronization with rotation of said cantilever gantry assembly and perpendicular to a rotation axis of said cantilever gantry assembly; and
during movement in said lateral plane, maintain an opening that allows said beam nozzle to protrude therefrom and toward said target object when said cantilever gantry assembly is located below said lateral plane during rotation; and
a track configured to be affixed to an external wall and to support the moving floor, wherein said track comprises a continuous rail comprising a lateral portion configured to guide said moving floor to move in said lateral plane,
wherein the moving floor comprises two floor sections each configured to move in said lateral plane, and wherein further said opening is variable and corresponds to a gap between said two floor sections, and wherein each floor section comprises a plurality of floor segments interconnected in sequence by bogies, and wherein further each of said plurality of floor segments is configured to be supported by said continuous rail in a cantilevered manner through said bogies.

US Pat. No. 10,426,976

NITINOL ORGAN POSITIONER TO PREVENT DAMAGE TO HEALTHY TISSUE DURING RADIATION ONCOLOGY TREATMENTS

The University of Toledo,...

1. An organ repositioner device comprising:an inflatable balloon mounted on a bendable tube defining a lumen, the lumen housing an assembly of a shape memory (SM) element and a superelastic (SE) element, wherein the SM element comprises a first shape memory alloy and has a first shape set form, and the SE element comprises a second shape memory alloy and has a second shape set form;
wherein the bendable lumen bends upon shape transformations of the assembly, and the assembly has an equilibrium shape between the first shape set form and the second shape set form.

US Pat. No. 10,426,975

ELASTICITY IMAGING-BASED METHODS FOR IMPROVED GATING EFFICIENCY AN DYNAMIC MARGIN ADJUSTMENT IN RADIATION THERAPY

KONINKLIJKE PHILIPS N.V.,...

1. A therapy plan execution control system comprising:at least one processor programmed to:
receive initial elasticity data indicative of a location of the target generated prior to execution of a fraction of a treatment plan for the target;
receive additional elasticity data indicative of a location of the target generated during execution of the fraction;
compare the initial elasticity data and the additional elasticity data to identify at least one of motion of the target and changes of the target;
during execution of the fraction, identifying real-time changes in the target due to therapy delivery based on the comparison; and
controlling execution of the fraction based on the identified changes in the target;
wherein the comparing of the initial elasticity data to the additional elasticity data comprises using intra-fraction elasticity imaging to identify real-time changes occurring in the target due to therapy delivery, and using inter-fraction elasticity imaging to identify target shrinkage, and further comprising adjusting the margins of the treatment plan and reoptimizing the treatment plan upon a determination that the target has changed in size.

US Pat. No. 10,426,974

TREATMENT PLANNING SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. A treatment planning system configured for determining a set of catheter or needle insertion positions to be used during treatment comprising:a computer processor configured to:
receive a medical image of a patient including a treatment target structure to be treated;
retrieve a set of predetermined standard patterns for catheter or needle insertion comprising a plurality of catheter or needle insertion positions, wherein the catheter or needle positions are positions from which inserted catheters or needles intersect the treatment target structure in a standardized patient; and
adapt one or more standard patterns of the set of predetermined standard patterns to a geometry of the patient with the treatment target structure to be treated with the catheters or needles by using a cost function, wherein the cost function comprises a penalty term for deviations of the adapted one or more standard patterns from a symmetry and/or shape of the adapted one or more standard patterns.

US Pat. No. 10,426,973

VIVO DRUG DEVELOPMENT AND DELIVERY SYSTEMS AND METHODS

1. A method of producing and administering a therapeutic drug to a patient, said method comprising:piercing the skin of the patient and positioning an ionizable substrate drug delivery apparatus at a treatment area inside a tissue of the patient;
directing an ionizable substrate solution into a chamber of the ionizable substrate drug delivery apparatus;
exposing the ionizable substrate solution to ionizing radiation in the chamber, thereby converting the ionizable substrate solution to free radicals; and
injecting the free radicals into said tissue of the patient
wherein:
the ionizable substrate delivery apparatus comprises:
an outer cannula configured for piercing the skin of the patient;
a body defining an inner chamber for receiving an ionizable substrate solution;
a structure within the inner chamber for transmitting ionizing radiation to the ionizable substrate solution in the chamber thereby developing a free radical drug; and
an applicator for directing the free radical drug from the chamber to a treatment site.

US Pat. No. 10,426,972

METHODS OF TREATING MELANOMA

MALIGNANT MELANOMA, LLC, ...

1. A method for treating cutaneous malignant melanoma in a subject comprising irradiating cutaneous malignant melanoma on the skin of the subject with at least two fractions of radiation per day, said fractions of radiation being selected from about 100 centiGray (cGy) or about 135 centiGray (cGy) and said fractions being separated by a time interval of at least about 0.5 hour.

US Pat. No. 10,426,971

PHOTOTHERAPY DEVICE WITH PAIN LOCATION INPUT

KONINKLIJKE PHILIPS N.V.,...

1. A phototherapy device for relieving nociceptive pain of a body part of a user by illumination of at least a part of the body part, comprising:a patch structure arranged to conform to at least a part of the body part;
a controllable light source system comprising at least one light source arranged on the patch structure so as to allow phototherapeutic illumination of at least a part of the user's body part, when the patch structure is positioned on the body part;
a user interface having a touch sensitive panel arranged on the opposite side to the side conforming to the at least a part of the body part, wherein the touch sensitive panel is arranged to sense a force applied by an input of the user corresponding to the noicipceptive pain such that the input from the user corresponds to a spatial position on the body; and
a control system arranged to control the controllable light source system in accordance with the input from the user such that the phototherapeutic illumination is correlated to the force applied by the input of the user.

US Pat. No. 10,426,970

IMPLANTABLE OPTICAL STIMULATORS

The Board of Trustees of ...

1. A device for stimulating target cells having light-responsive proteins in an animal, the device comprising:an elongated light-delivery structure configured for insertion in a narrow passageway in the animal, the elongated light-delivery structure having a distal end, a proximal end, an array conformed to an outer surface around a circumference of the distal end, and a plurality of separately-activatable light-delivery elements, wherein each light-delivery element extends from the proximal end to the array and separately terminates at an aperture at a specific array location;
a control circuit for activating less than all the light-delivery elements that are electrically connected in parallel to deliver light to light-responsive proteins adjacent to the activated light-delivery elements along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo, wherein groups of separately-activatable light-delivery elements are affixed to each other to form a ring;
a multichannel driver configured to individually control the light-delivery elements;
a sensor for detecting a measure of performance of the animal; and
a computer configured for storing the measure of performance of the animal and using the measure of performance of the animal to determine a neuromodulation parameter for the multichannel driver, wherein the neuromodulation parameter is a direction of the light emitted from the array of light-delivery elements,
wherein the device is configured to:
generate sets of candidate neuromodulation parameters, wherein the sets of candidate neuromodulation parameters comprise control information for the plurality of light-delivery elements;
activate the plurality of light-delivery elements according to one or more of the sets of candidate neuromodulation parameters;
detect neuromodulation effects from the activation of the plurality of light-delivery elements;
correlate the one or more sets of candidate neuromodulation parameters with the detected neuromodulation effects; and
select one of the sets of candidate neuromodulation parameters as a treatment regimen for the animal.

US Pat. No. 10,426,969

MAGNETIC FIELD STIMULATION

The McLean Hospital Corpo...

1. A system comprising:a pulse generator; and
a magnetic coil comprising a first element, an inner surface of the first element forming at least a part of a spherical surface, the first element being in electrical communication with the pulse generator,
wherein a parameter of the magnetic coil is selected such that the coil produces a gradient magnetic field proximate to a region at least partially enclosed by the spherical surface, the gradient magnetic field inducing an electric field in air up to about 50 V/m.

US Pat. No. 10,426,968

NEURAL MODULATION SYSTEM

Palo Alto Research Center...

1. A vision prosthetic system, comprising:a camera configured to provide camera signals in response to images;
a patient-external device comprising:
a neural encoder programmed to convert the camera signals into a neural stimulation pattern; and
communication circuitry configured to wirelessly transmit the stimulation pattern to a patient-internal device configured to be disposed within a cranium of a patient;
the patient-internal device comprising:
communication circuitry configured to wirelessly receive the stimulation pattern from the patient-external device;
an implantable neural subsystem, comprising:
a flexible substrate;
a two dimensional array of neural probes disposed on the flexible substrate, the neural probes configured to stimulate and sense neurons, each neural probe comprising:
an array of magnetic neural stimulators configured to magnetically stimulate neurons;
an array of neural sensors configured to sense neural signals of the neurons; and
probe addressing circuitry comprising thin film switches; and
control circuitry configured to control activation of the magnetic neural stimulators and neural sensors according to the neural stimulation pattern via the probe addressing circuitry.

US Pat. No. 10,426,967

APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT OF NEUROLOGICAL INJURY OR CONDITION CAUSED BY A STROKE

Endonovo Technology, Inc....

1. A method for treating a neurological injury or condition caused by a stroke in a patient in need thereof, the method comprising:providing a treatment apparatus including
a signal generator connected to a circular wire applicator having a diameter that allows encircling the patient's head, and
a sensor configured to detect the patient's intracranial pressure;
placing the circular wire applicator over and around the patient's head and in proximity to a target region for treatment through the patient's skull;
activating the signal generator to generate a pulsed electromagnetic field in the circular wire applicator, wherein the pulsed electromagnetic field comprises a burst of between 15-40 MHz, wherein the burst repeats at between 0.01 and 100 Hz; and
reducing the patient's intracranial pressure by applying the pulsed electromagnetic field until the sensor detects that the patient's intracranial pressure has been reduced to a desired level.

US Pat. No. 10,426,966

WEARABLE CARDIOVERTER DEFIBRILLATOR (WCD) SYSTEM INFORMING PATIENT THAT IT WILL NOT SHOCK RESPONSIVE TO JUST-SELF-TERMINATED CARDIAC ARRHYTHMIA

WEST AFFUM HOLDINGS CORP....

1. A wearable cardioverter defibrillator (“WCD”) system, comprising: a support structure configured to be worn by a patient; a power source; an energy storage module configured to receive an electrical charge from the power source, and to store the received electrical charge; a discharge circuit coupled to the energy storage module, the discharge circuit controllable to discharge the stored electrical charge so as to cause a shock to be delivered to the patient while the support structure is worn by the patient; a discharge circuit coupled to the energy storage module, the discharge circuit controllable to discharge the electrical charge so as to cause a shock to be delivered to the patient; a measurement circuit configured to render physiological inputs from an ElectroCardioGram (ECG) signal of the patient; a user interface configured to output one or more human-perceptible indications; and a processor configured to: detect a cardiac arrhythmia of the patient from one of the physiological inputs; then determine, from a subsequent one of the physiological inputs, whether or not the detected cardiac arrhythmia is validated according to a validation criterion; and if the detected cardiac arrhythmia is not so validated, then cause a closing human-perceptible indication to be output, the closing human-perceptible indication configured to communicate to the patient that it was decided not to shock responsive to the detected cardiac arrhythmia, and to further control the discharge circuit to not deliver a shock for at least 25 min from when it was determined that the detected cardiac arrhythmia is not so validated; else if the detected cardiac arrhythmia is so validated, control the discharge circuit to instead deliver a shock within 2.5 min from when it was determined that the detected cardiac arrhythmia is so validated.

US Pat. No. 10,426,965

METHOD AND APPARATUS FOR DETERMINING BATTERY CAPACITY IN A DEFIBRILLATOR

Scion Medical Limited, H...

1. A method for notifying a user to replace a battery in a defibrillator, the method comprising:measuring the battery voltage during operation of the defibrillator;
counting the number of shocks delivered during operation of the defibrillator; and
notifying the user that the battery in the defibrillator needs to be replaced when:
(i) the number of shocks delivered during operation of the defibrillator is >19; or
(ii) the number of shocks delivered during operation of the defibrillator is >6 and the battery voltage measured during operation of the defibrillator is <9.03 volts; or
(iii) the number of shocks delivered during operation of the defibrillator is between 6 and 4, and the battery voltage measured during operation of the defibrillator is <7.87 volts; or
(iv) the number of shocks delivered is between 3 and 1, and the battery voltage measured during operation of the defibrillator is <7.39.

US Pat. No. 10,426,963

ESTIMATING SHOCK SUCCESS BY MONITORING CHANGES IN SPECTRAL DATA

ZOLL Medical Corporation,...

1. A system comprising:one or more electronic ports for receiving signals from sensors for obtaining a time domain electrocardiogram (ECG) of a patient;
a patient treatment module comprising an ECG analyzer and a non-transitory computer-readable storage medium encoded with a computer program comprising instructions that, when executed, cause one or more processors to perform operations comprising:
performing at least one transformation of at least a portion of a time domain ECG signal from the patient into frequency domain data,
determining a first frequency-based value over a first evaluation period based on the at least one transformation,
determining a second frequency-based value representing an upward trend over a second evaluation period based on the at least one transformation, and
determining a probability of therapeutic success based at least in part on the first frequency-based value and the second frequency-based value; and
an output device for presenting an indication of the probability of therapeutic success.

US Pat. No. 10,426,962

LEADLESS PACEMAKER USING PRESSURE MEASUREMENTS FOR PACING CAPTURE VERIFICATION

CARDIAC PACEMAKERS, INC.,...

1. An implantable medical device in the form of a cardiac pacemaker, comprising:at least first and second electrodes for at least one of delivering therapy or sensing electrical signals;
a pressure sensor for sensing intracardiac pressure;
operational circuitry coupled to the electrodes and the pressure sensor; and
a housing sized and adapted for placement in or on the heart of a patient, the housing containing at least the operational circuitry;
wherein the operational circuitry is configured to perform a pressure based capture verification process including the following:
deliver an electrical pacing stimulus to the heart of a patient using the at least first and second electrodes;
obtaining a pressure signal received with the pressure sensor over a period of time following delivery of the electrical pacing stimulus;
monitor for an evoked capture response indicating the electrical pacing stimulus was captured using the pressure sensor by identifying a peak in the pressure signal and determining a temporal relationship of the peak in the pressure signal to a second signal event; and
if the evoked capture response is detected, conclude that the electrical pacing stimulus captured at least a portion of the patient's heart; and
if the evoked capture response is not detected, conclude that the electrical pacing stimulus did not capture the patient's heart.

US Pat. No. 10,426,961

DYNAMIC STIMULATION ADJUSTMENT FOR IDENTIFICATION OF A NEURAL FULCRUM

LivaNova USA, Inc., Hous...

1. A neurostimulation system, comprising:an implantable medical device (IMD) comprising a neurostimulator coupled to an electrode assembly, the neurostimulator adapted to deliver stimulation signals to a patient, each stimulation signal comprising an ON time and an OFF time; and
a control system programmed to:
monitor a heart rate of a patient implanted with the IMD during delivery to the patient of a plurality of stimulation signals at a first frequency, each stimulation signal having at least one parameter setting different than parameter settings of the other stimulation signals in the plurality of stimulation signals, wherein monitoring the heart rate comprises monitoring a baseline heart rate during the OFF time periods of each stimulation signal and monitoring a heart rate response during the ON time periods of each stimulation signal, the heart rate response comprising a percentage change from the baseline heart rate;
compare the percentage change of the heart rate response for each of the plurality of stimulation signals to a first threshold and a second threshold less than the first threshold; and
deliver stimulation comprising one or more stimulation signals from the plurality of stimulation signals causing a percentage change of the heart rate response between the first and second thresholds.

US Pat. No. 10,426,960

ANTENNA ASSEMBLY FOR SUPPLYING POWER TO AN IMPLANTABLE NEURAL STIMULATOR DEVICE

Stimwave Technologies Inc...

1. An antenna assembly, comprising:a metal layer configured to emit linearly polarized electromagnetic energy to a receiving antenna implanted underneath a subject's skin such that the receiving antenna implanted underneath the subject's skin is wirelessly powered by the linearly polarized electromagnetic energy emitted from the antenna assembly; and
a feed port configured to connect the antenna assembly to a signal generator such that the antenna assembly receives an input signal from the signal generator and then drives the metal layer using the input signal to emit the linearly polarized electromagnetic energy to the receiving antenna,
wherein the antenna assembly is less than 200 ?m in thickness, and
wherein the metal layer is operable as a dipole antenna with a reflection ratio of at least 6 dB, the reflection ratio corresponding to a ratio of a transmission power of the antenna assembly when driven by the input signal and a reflection power seen by the antenna assembly resulting from emission of the linearly polarized electromagnetic energy to the receiving antenna implanted underneath a subject's skin.

US Pat. No. 10,426,959

SYSTEMS AND METHODS TO PLACE ONE OR MORE LEADS IN TISSUE FOR PROVIDING FUNCTIONAL AND/OR THERAPEUTIC STIMULATION

SPR THERAPEUTICS, INC., ...

1. A method to reduce and/or relieve pain in a painful region comprising:percutaneously inserting a coiled lead through skin of a patient;
positioning an electrode extending from the coiled lead into adipose or connective tissue outside of the painful region;
stimulating a peripheral nerve innervating the painful region with the electrode, wherein the electrode is positioned near the peripheral nerve; and
evoking a tingling sensation over at least a portion of the painful region without damaging the peripheral nerve.

US Pat. No. 10,426,957

STIMULATION MANAGEMENT

Cochlear Limited, Macqua...

1. A method, comprising:i. obtaining nullity weighting information based on artefact voltages at a first location in a recipient for at least one current level of a plurality of respective first current levels respectively applied to respective electrodes of a sensory prosthesis configured to stimulate tissue of the recipient to evoke a sensory percept;
ii. simultaneously stimulating the respective electrodes at respective second current levels such that a neural response is found at the first location, at least one of the second current levels being weighted by the nullity weighting information; and
iii. automatically recording the neural response resulting from action “ii.”

US Pat. No. 10,426,956

SYSTEM AND METHOD FOR MONITORING AND CONTROLLING NERVOUS SYSTEM BEHAVIOR USING AUTONOMIC FEATURES

University of Florida Res...

1. A system for stimulating the central nervous system via a peripheral nerve input into the autonomic nervous system of a human patient in accordance with the state of the parasympathetic branch of the autonomic nervous system, comprising:monitoring means for continuously monitoring an index of parasympathetic nervous system behavior of the patient;
stimulating means for stimulating the autonomic nervous system, wherein the stimulating means stimulates the vagus nerve or trigeminal nerve so that the central nervous system is affected; and
controlling means operatively connected to the monitoring means and to the stimulating means, the controlling means continuously regulating the stimulating means in a manner that said autonomic nervous system is stimulated in accordance with the monitored index of parasympathetic nervous system behavior of the patient,
wherein the monitored index comprises respiratory sinus arrhythmia, and, optionally, further comprises hippus variability, skin conductance, blood pressure, blood pressure variability or heart rate, and
wherein the controlling means regulates the stimulating means to provide minimal stimulation intensity to increase the monitored index via effects on the central nervous system while not causing patient discomfort.

US Pat. No. 10,426,955

METHODS FOR IMPLANTING ELECTRODES AND TREATING A PATIENT WITH GASTREOSOPHAGEAL REFLUX DISEASE

EndoStim, Inc., Dallas, ...

5. A method of implanting a first electrode and a second electrode in a patient in order to treat gastroesophageal reflux disease, comprising:implanting the first electrode in a stomach of the patient;
implanting the second electrode in a stomach of the patient, wherein the second electrode is positioned skew relative to the first electrode,
connecting the first electrode and the second electrode to a pulse stimulator configured to supply a stimulation pulse to the first electrode and the second electrode;
programming the pulse stimulator to apply a train of stimulation pulses, wherein the pulse stimulator is not in data communication with an implanted sensor configured to sense a physiological state of the patient; and
operating the first electrode and the second electrode in combination to deliver the stimulation pulses to normalize a function of a lower esophageal sphincter (LES) of the patient post-stimulation.

US Pat. No. 10,426,954

LEAD ELECTRODE FOR USE IN AN MRI-SAFE IMPLANTABLE MEDICAL DEVICE

MEDTRONIC, INC., Minneap...

1. A medical lead configured to be implanted into a patient's body, the lead comprising:an elongated lead body having a proximal end and a distal end;
a first conductive filer that is coupled to an electrical contact at the proximal end and that passes through an interior of the lead body to the distal end;
a second conductive filer that is coupled to an electrical contact at the proximal end and that passes through an interior of the lead body to the distal end;
a first electrode that comprises a ring that is coupled to said lead body at the distal end and coupled to the first conductive filer;
a second electrode that comprises a ring that is coupled to said lead body distally of the first electrode at the distal end and coupled to the second conductive filer;
a floating electrode coupled to said lead body and comprising a ring portion and an extension from the ring portion that is capacitively coupled to the first electrode and to the second electrode, wherein the extension of the floating electrode is positioned within the rings of the first and second electrodes.

US Pat. No. 10,426,952

DELIVERY OF CARDIAC STIMULATION DEVICES

BOSTON SCIENTIFIC SCIMED,...

1. A method of implanting a wireless electrode assembly into a heart, comprising:advancing a device through a cardiovascular system of a patient to an implantation site of a wall of a heart;
observing, on an electrocardiogram (ECG), electrical activity of the heart using a sensing electrode on the device and in electrical communication with the ECG;
determining, before penetration of the wall of the heart by a wireless electrode assembly, if the implantation site is suitable for receipt of the wireless electrode assembly based on the observed electrical activity of the heart on the ECG; and
thereafter, deploying the wireless electrode assembly at the implantation site if based on determining, before penetration of the wall of the heart by the wireless electrode assembly, that the implantation site is suitable for receipt of the wireless electrode assembly such that the wireless electrode assembly is fully implanted and anchored into the wall of the heart, the wireless electrode assembly including a body sized to be positioned within a chamber of the heart, the body containing circuitry for delivering electrical stimulation to heart wall tissue from a first electrode of the wireless electrode assembly, through the heart wall tissue, and to a second electrode of the wireless electrode assembly.

US Pat. No. 10,426,951

MEDICAL TOOL EMPLOYING A WARNING MECHANISM NOTIFYING THAT A ROTATIONAL LIMIT HAS BEEN REACHED

PACESETTER, INC., Sylmar...

1. A medical tool comprising a handle including:a housing;
a torque portion operably coupled to the housing and rotatable relative to the housing, the torque portion including a shaft including an outer circumferential surface and a helical thread portion radially outwardly extending from the outer circumferential surface of the shaft;
a shuttle displaceable along the shaft via threaded interaction with the helical thread portion; and
a warning mechanism interacting with the shuttle that provides a tactile indication when the torque portion has rotated a number of rotations, the warning mechanism comprising a stop disposed between the shuttle and a structural element of the housing, the tactile indication being provided by the shuttle contacting the stop, wherein the medical tool is a delivery system for delivering a leadless pacemaker into cardiac tissue.

US Pat. No. 10,426,949

SYSTEMS AND METHODS FOR OPTIMIZING PROGRAMMING AND USE OF NEUROMODULATION SYSTEMS

Regents of the University...

1. A method for programming a pulse generator with a configuration for a deep brain stimulation array including one or more electrodes, the configuration including a stimulation setting for each electrode in the deep brain stimulation array, the method comprising:identifying one or more grid points representing a target tissue to be activated by stimulation through the one or more electrodes;
identifying one or more objective values to be balanced, the objective values being calculable based on the one or more grid points and a configuration;
generating one or more configurations, such that each configuration is Pareto optimal in terms of the objective values calculated based on the one or more grid points and the configuration;
presenting the one or more configurations to a user;
receiving from the user a selected one of the one or more configurations; and
providing, to a pulse generator capable of delivering therapy via each of the one or more electrodes, the selected configuration.

US Pat. No. 10,426,948

EXTENDABLE ELECTRODE

1. An implantable electrode comprising:at least one contact element for contacting bodily tissue;
a connection portion comprising at least one connecting line for connecting a medical device to the at least one contact element; and
a cylindrical core,
wherein the cylindrical core is flexible along a longitudinal axis of the electrode,
wherein the connection portion is wound around the core and individual turns, or all turns, in the wound form of the cylindrical portion are fastened to the core, and
wherein the connection portion is formed flat and the at least one connecting line is embedded in the flat connection portion,
wherein the at least one connecting line is arranged between two electrically insulating thermoplastic polymer films which are permanently connected to one another,
wherein a first of the two films is planer and has the at least one contact element formed on one of its sides and the at least one connecting line formed on a side of the first film opposite the at least one contact element,
wherein a second of the two films is planar and is connected to the first film on the one side of the first film where the at least one connecting line is formed,
wherein the first and second films forming the connection portion are wound around the core.

US Pat. No. 10,426,947

IMPLANTABLE ELECTRODE WITH HOLLOW CYLINDRICAL SHEATH

1. An implantable electrode comprising:a sheath extending along a longitudinal axis of the electrode, the sheath being made of an electrically insulating material; and
at least one connection cable, wherein the connection cable is at least partly embedded in the sheath and the sheath has a hollow cylindrical shape,
wherein the hollow cylindrical shape of the sheath has an inner side and an outer side,
wherein the electrode has at least one contact element, wherein the at least one contact element has a feedthrough passing through the sheath and forming an electrically conductive connection with the at least one connection cable,
wherein the at least one contact element sits on the outer side of the sheath,
wherein the at least one connection cable is arranged between two electrically insulating thermoplastic polymer films which are permanently connected with one another,
wherein a first of the two films is planar and has the at least one connection cable formed on one of its sides and the at least one contact element formed on a side of the first film opposite the at least one connection cable
wherein a second of the two films is planar and is connected to the first film on the one side of the first film where the at least one connection cable is formed.
wherein the first and second films forming the sheath are wrapped in the form of the hollow cylindrical shape, and
wherein to connect the at least one connection cable and the at least one contact element together the feedthrough is provided with a metalized opening in the one film connecting the two sides of the one film with one another.

US Pat. No. 10,426,946

WEARABLE DEFIBRILLATOR WITH AUDIO INPUT/OUTPUT

ZOLL Medical Corporation,...

1. A wearable defibrillator comprising:a plurality of ECG electrodes configured to be removably attached to a patient and configured to sense a cardiac condition of the patient;
at least one therapy pad configured to deliver electrical therapy to the patient;
at least one audio device, the at least one audio device including
a microphone configured to receive an audio input and sense environmental noise, and
a speaker configured to output one or more alarms signaling that treatment is about to be provided to the patient; and
at least one processor operatively connected to the plurality of ECG electrodes, the at least one therapy pad, a memory, and the at least one audio device, the at least one processor configured to
monitor the sensed cardiac condition, and
increase a volume of the one or more alarms when the microphone senses from the environmental noise that the wearable defibrillator is in a high noise environment.

US Pat. No. 10,426,945

METHODS AND APPARATUSES FOR TRANSDERMAL STIMULATION OF THE OUTER EAR

Thync Global, Inc., Los ...

1. A wearable pinna transdermal electrical stimulation (TES) device for modifying a subject's cognitive state by applying TES to the subject's pinna, the device comprising:a first body adapted to be worn in a pinna region of a first ear;
a second body adapted to be worn in a pinna region of a second ear;
a first electrode on the first body;
a second electrode on the second body; and
a wearable TES controller coupled to the first and second bodies and comprising a power source, a processor, a timer, and a waveform generator, wherein the TES controller is adapted to deliver an asymmetric biphasic electrical stimulation signal of 10 seconds or longer between the first and second electrodes having a peak intensity of greater than 0.20 mA and a frequency of between 3 kHz and 50 kHz, wherein the TES controller is adapted to shift the frequency of the asymmetric biphasic electrical stimulation during the delivery of the asymmetric biphasic electrical stimulation in bursts of increased frequency or decreased frequency waveforms.

US Pat. No. 10,426,944

LONG-TERM WEAR ELECTRODE

ZOLL Medical Corporation,...

1. An electrode for use with a therapeutic current delivery system, comprising:a non-conductive, flexible, water vapor-permeable, electrically-insulating top layer; and
a flexible, water vapor-permeable, conductive adhesive material disposed on one side of the electrically-insulating top layer,
wherein the conductive adhesive material is conductive in a direction substantially orthogonal to the plane of the electrode and semi-conductive in a direction substantially lateral to the plane of the electrode; and
wherein the electrode has an overall water vapor permeability greater than 100 gm/m2/24 hours.

US Pat. No. 10,426,943

INSERT FOR LUER CONNECTION

Attwill Medical Solutions...

1. An insert for a luer-type catheter connection, comprising:a male end shaped for insertion into a female luer fitting of a catheter;
a female end shaped to receive and attach to a male luer nozzle of a fluid delivery device;
a fluid pathway connecting the female end and the male end;
a cartridge located in the fluid pathway; and
a patency agent held by the cartridge, wherein the patency agent comprises an antiseptic, wherein the cartridge is positioned for the patency agent to be released from the cartridge and into the catheter as a locking fluid flows through the fluid pathway and comes in direct contact with the patency agent to thereby lock the locking fluid and the patency agent within a lumen of the catheter, wherein the cartridge is sized and shaped such that locking fluid flows around the cartridge, and wherein the cartridge is sized and shaped to leave an intervening space between the cartridge and the male luer nozzle of the fluid delivery device when attached to the female end.

US Pat. No. 10,426,942

CONNECTION STRUCTURE FOR IV TUBE OF IV INFUSION SET

MEDILINE ACTIVE KOREA CO....

1. A connection structure for an IV tube of an IV infusion set, in which an outlet provided on an IV bag is connected to a drip chamber, the IV tube is connected to the drip chamber to allow an IV fluid to flow, an injection site for injecting the IV fluid into a patient is connected to an end of the IV tube, and a Y-port, a three-way stopcock, a filter, a luer lock, in addition to the drip chamber and the injection site are connected to the IV tube, the connection structure comprising:a connector provided on an outer circumferential surface of the IV tube to lock the IV tube, with at least one of the drip chamber, the injection site, the Y-port, the three-way stopcock, the filter, and the luer lock being connected to the IV tube,
wherein the connector is formed in an annular ring shape to be fitted over the outer circumferential surface of the IV tube, with an insertion part being provided in the connector to allow the IV tube to be inserted therein, and wherein an inner wall of the connector is tapered downward from a top end of the connector such that the IV tube firmly and directly contacts at least one of the drip chamber, the injection site, the Y-port, the three-way stopcock, the filter, and the luer lock at a bottom end of the connector.

US Pat. No. 10,426,941

NASAL TUBE DEVICE AND METHOD

APPLIED MEDICAL TECHNOLOG...

1. A nasal tube system comprising: a nasal tube, the nasal tube comprising:a first opening at a proximal end;
a second opening at a distal end;
a delivery window between the proximal end and the distal end and in an outer surface of the nasal tube;
a main lumen extending an entire length of the nasal tube from the first opening to the second opening;
a delivery lumen extending from the first opening to the delivery window; and
a wall at least partially separating and defining the main lumen and the delivery lumen,
wherein the nasal tube is configured to be inserted into a first nostril of a patient with the proximal end and the first opening positioned outside of the patient, and the second opening and the delivery window open to pharyngeal space of the patient; and a flexible line that secures the nasal tube to the patient by extending through the delivery lumen and the delivery window of the nasal tube.

US Pat. No. 10,426,939

DISPOSABLE LIQUID APPLICATOR SACHET

DAKLAPACK EUROPE B.V., L...

1. A disposable liquid applicator sachet, comprising:a base sheet and a top sheet, each of the base sheet and the top sheet having a reservoir sheet portion and an applicator sheet portion, and said top sheet being sealed onto said base sheet such that the reservoir sheet portions of said base sheet and said top sheet define therebetween a reservoir for holding a liquid, and the applicator sheet portions of said base sheet and said top sheet define therebetween a conduit, which conduit extends from the reservoir up to an outlet opening provided in the applicator sheet portion of the top sheet; and
an applicator pad, which applicator pad is attached to the applicator sheet portion of the top sheet, such that the applicator pad covers the outlet opening,
wherein the disposable liquid applicator sachet is folded with an applicator portion thereof onto a reservoir portion thereof, and wherein a sharp fold is present between the reservoir portion of the disposable liquid applicator sachet and the applicator portion of the disposable liquid applicator sachet, which sharp fold blocks the conduit to such an extent that the liquid held in the reservoir is prevented from flowing into the conduit,
wherein the applicator portion of the disposable liquid applicator sachet is sealed onto the reservoir portion of the disposable liquid applicator sachet in sealing zones, which sealing zones are located on opposite sides of the conduit, and which sealing zones extend up to the fold,
wherein the applicator portion of the disposable liquid applicator sachet comprises a tear line on each side of the conduit, which tear lines are each located between the conduit and a sealing zone and which tear lines extend from an edge of the applicator portion up to the sharp fold, and
wherein the applicator portion of the disposable liquid applicator sachet comprises a grip tab for pulling the applicator portion of the disposable liquid applicator sachet away from the reservoir portion of the disposable liquid applicator sachet, which grip tab is provided between the two tear lines at a distance from the fold, such that by pulling the grip tab away from the reservoir portion of the disposable liquid applicator sachet, the applicator portion tears along the tear lines and a part of the applicator portion of the disposable liquid applicator sachet, the part comprising the conduit and the outlet opening, can be unfolded to allow the liquid held in the reservoir to flow into the conduit and out of the outlet opening into the applicator pad.

US Pat. No. 10,426,938

MEDICAL DRESSING INTERFACE DEVICES, SYSTEMS, AND METHODS

KCI Licensing, Inc., San...

29. A method for instilling fluid at a tissue site, comprising:positioning a distribution manifold adjacent a surface of the tissue site, the distribution manifold comprising a tissue-facing side facing the tissue site and an outward-facing side opposite the tissue-facing side;
positioning an adapter adjacent the distribution manifold, the adapter comprising:
a conduit housing including a recessed region defining an entry surface, the entry surface facing the outward-facing side of the distribution manifold,
a primary port on the entry surface,
at least one ancillary port on the entry surface, and
at least one port extension including a proximal end, a distal end, and a bore between the proximal end and the distal end, the distal end of the port extension in fluid communication with the ancillary port through the bore;
inserting the distal end of the port extension into the distribution manifold; and
delivering fluid to the surface of the tissue site through the ancillary port and the distal end of the port extension.

US Pat. No. 10,426,937

BI-PHASE FLUID SURGE SUPPRESSOR DEVICE

1. A siphon guard comprising:a housing having an inlet and an outlet opposite the inlet, the inlet and outlet being axially alignable with a shunt flow path;
a primary flow path disposed within the housing and in fluid communication with the inlet and the outlet, the primary flow path having a generally axial orientation;
a secondary flow path disposed around the primary flow path and within the housing and in fluid communication with the inlet and the outlet, the secondary flow path having a generally helical orientation and a higher resistance to fluid flow than the primary path; and
a valve disposed within the primary flow path, the valve having a valve seat and a first ball and a second ball, the first ball being movable between a valve closed position where the first ball is moved towards the outlet and in contact with the valve seat and a valve open position where the first ball is moved away from the outlet and spaced from the valve seat thereby permitting egress of fluids from the valve from the first ball and then to the outlet distal thereof,
the first ball is disposed between the second ball and the valve seat,
the second ball being movable between the valve closed position and the valve open position;
wherein the second ball being movable by a weight of the second ball between the valve closed position and the valve open position, and
wherein the primary flow path forms a “u” bend between the inlet and the valve.

US Pat. No. 10,426,936

BALLOON CATHETERS WITH INCREASED COLUMN STRENGTH

BOSTON SCIENTIFIC SCIMED,...

1. A medical device, comprising:an expandable member having a proximal waist and a distal waist;
an outer member having a proximal end, a distal end and a lumen extending therein, wherein the outer member is attached to the proximal waist of the expandable member;
an inner member having a proximal end and a distal end, the inner member disposed within the lumen of the outer member, wherein the inner member is attached to the distal waist of the expandable member; and
a movement limiting member connecting the inner member to the outer member,
wherein the movement limiting member is a coil having a proximal end and a distal end, wherein the distal end of the coil is directly attached to the inner member;
wherein the movement limiting member is configured to limit movement of the outer member relative to the inner member.

US Pat. No. 10,426,935

REINFORCED SYRINGE BODY

Merit Medical Systems, In...

1. A syringe body configured for use in connection with a high-pressure inflation device, the syringe body comprising:a first wall defining a fluid reservoir, the fluid reservoir configured to receive a plunger;
a second wall defining a distal end of the fluid reservoir, the second wall comprising:
at least one stiffening rib; and
an inlet/outlet port disposed in the second wall,
wherein a distal end of the first wall extends distally relative to the second wall along a circumference of the second wall forming an annular stiffening lip,
wherein the second wall defines an interior surface of the fluid reservoir extending between the first wall and the inlet/outlet port, and
wherein the at least one stiffening rib extends inward of the annular stiffening lip along an exterior surface of the second wall.

US Pat. No. 10,426,934

BALLOON CATHETER

ABBOTT CARDIOVASCULAR SYS...

1. A balloon catheter comprising:an outer shaft including a hypotube and a monolithic single-layer distal outer member of polymer material, the outer shaft having an inflation lumen defined therethrough, wherein the monolithic single-layer distal outer member is necked to a reduced diameter along an entire length thereof with the polymer material consisting essentially of polymer chains in a linear orientation, wherein a proximal end of the monolithic single-layer distal outer member is coupled to the hypotube, and wherein a distal section of the hypotube comprises a skive defined by a first angled cut, an axial cut, and a second angled cut;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft coupled to a distal end of the monolithic single-layer distal outer member; and
a monolithic inner tubular member having a guidewire lumen defined therethrough, the monolithic inner tubular member extending distally from a proximal port in the monolithic single-layer distal outer member through the balloon to form a tip.

US Pat. No. 10,426,933

CATHETER HAVING MONOLITHIC MULTILAYER DISTAL OUTER MEMBER

ABBOTT CARDIOVASCULAR SYS...

1. A balloon catheter, comprising:an outer shaft including a hypotube and a monolithic multilayer distal outer member of polymer material, the outer shaft having an inflation lumen defined therethrough, the monolithic multilayer distal outer member having a proximal end portion and a distal end portion, the monolithic multilayer distal outer member having an inner layer comprising a first polymer having a tensile strength greater than 8,000 psi and an outer layer comprising a second polymer having a flexural modulus of less than 130,000 psi at room temperature, wherein a proximal end of the monolithic multilayer distal outer member is coupled to the hypotube, wherein the monolithic multilayer distal outer member is necked to a reduced diameter along an entire length thereof with the polymer material consisting essentially of polymer chains in a linear orientation;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft coupled to a distal end of the monolithic multilayer distal outer member; and
an inner tubular member having a guidewire lumen defined therethrough, the inner tubular member extending distally from a proximal port in the proximal end portion of the monolithic multilayer distal outer member through at least a portion of the balloon.

US Pat. No. 10,426,932

METHOD AND APPARATUS FOR INTRODUCING AN INTRAVENOUS CATHETER

1. An I.V. catheter insertion assembly comprising:a) a tubular member that is transparent and has a body, a first end, and a second end, wherein the first end is located at a proximal end of the body and is mammillated, and wherein the second end is located at a distal end of the body;
b) a plunger assembly slidable within the body of said tubular member, the plunger assembly having a chamber that is continuous and transparent, and the plunger assembly having a finger paddle and a control knob at a distal end of the plunger assembly;
c) said chamber of the plunger assembly in fluid communication with said control knob at the distal end of the plunger assembly;
d) a needle base and a sealing member that is air-tight, wherein the sealing member is at a proximal end of the chamber, the sealing member in slidable vacuum sealing contact along an interior surface of the body of the tubular member;
e) a needle that is elongated, beveled, and tubular, the needle embedded within said needle base and extending therefrom with said needle in fluid communication with said chamber, and the needle having a needle tip;
f) an I.V. catheter comprising a cannula, wherein the cannula is flexible, transparent, and is an I.V. cannula, the cannula having a cannula tip and a hub that is transparent, the hub attached to said first end of the tubular member with said needle operable to pass longitudinally through said cannula;
g) the plunger assembly operable to move within the tubular member between a neutral position and one or more retracted positions, wherein in the neutral position the sealing member and needle base are at or near a junction of the first end of the tubular member and the body, and wherein the needle passes longitudinally through said cannula and with the needle tip extending exterior to said cannula tip, and wherein in the one or more retracted positions the needle tip is retracted to an interior of the cannula;
h) a fluid passage formed in a space between said needle and said cannula when the needle passes longitudinally through said cannula; and
i) wherein when moving to the one or more retracted positions, retraction of the plunger assembly causes a vacuum in the fluid passage and suction on the cannula tip, said suction visibly drawing blood into the fluid passage and along a longitudinal length of the fluid passage enabling a user to verify that the cannula has entered a blood vessel.

US Pat. No. 10,426,931

CATHETER PLACEMENT DEVICE AND METHOD

C. R. Bard, Inc., Murray...

1. An insertion tool for inserting a catheter into a body of a patient, comprising:a housing;
a needle having a proximal portion in the housing and a distal portion extending from a distal end of the housing;
a catheter advancement assembly, comprising:
the catheter coaxially disposed over the needle, the catheter having a proximal end in the housing and a distal end extending from the distal end of the housing in a catheter first position; and
a handle coupled to the proximal end of the catheter, the handle extending laterally from the housing in the catheter first position, the handle slidable with respect to the housing to transition the catheter distally from the catheter first position to a catheter second position; and
a guidewire advancement assembly, comprising:
a guidewire disposed at least partially in a lumen of the needle; and
a slide member coupled to the guidewire, the slide member slidable with respect to the housing to transition the guidewire relative to the needle.

US Pat. No. 10,426,930

SYSTEMS AND METHODS FOR NEEDLE AND CATHETER ADVANCEMENT

Vascular Pathways, Inc., ...

1. A method, comprising:obtaining a medical device, comprising:
a catheter; and
a needle including a dilating element permanently attached to an exterior of the needle at a distal portion of the needle proximate a tissue-penetrating distal end thereof, the dilating element having an outer diameter equal to or greater than a diameter of an opening at a distal end of the catheter, the needle situated in a first medical device position such that at least a portion of the dilating element is in the opening and the tissue-penetrating distal end is distal of the opening;
penetrating a vein with the tissue-penetrating distal end of the needle;
moving the distal end of the catheter into the vein;
advancing the catheter into the vein over the needle; and
removing the needle from the catheter.

US Pat. No. 10,426,929

INTEGRATED PERIPHERAL INTRA-VENOUS CATHETER WITH IMPROVED EXTENSION TUBE PORT PROBE ACCESS

Becton, Dickinson and Com...

1. A vascular access device, comprising:a catheter for insertion into a biological site;
a catheter adapter having a catheter hub and a side port coupled to the catheter hub, the catheter hub having a first end operably coupled to the catheter, a second end opposite the first end, and an internal wall defining an internal fluid passageway therebetween, the side port having another internal wall defining a lumen in fluid communication with the internal fluid passageway, wherein the other internal wall of the side port comprises a distal surface and a proximal surface opposite the distal surface, wherein the side port further comprises a protrusion extending outwardly from the proximal surface; and
a septum disposed within the internal fluid passageway;
wherein the protrusion is configured to deflect a probe entering the catheter hub from the side port towards the first end of the catheter hub such that the probe contacts the internal wall at a contact angle between 90 degrees and 180 degrees.

US Pat. No. 10,426,927

TELESCOPING CATHETERS AND METHODS FOR USE

CLPH, LLC, Palo Alto, CA...

1. An apparatus for performing a medical procedure within a patient's body, comprising:a first elongate member comprising a first proximal portion, a first distal portion sized for introduction into a patient's body and including a first distal end, and a lumen extending between the first proximal portion and the first distal end;
a second elongate member comprising a second proximal portion, a second distal portion slidably received within the lumen and including a second distal end, the second elongate member being movable relative to the first elongate member between a retracted position and a distal position where the second distal end extends distally from the first distal end; and
cooperating magnetic elements on the first and second distal ends at locations to secure the second elongate member at the retracted position using a magnetic attraction between the magnetic elements, the magnetic attraction being such that a predetermined force disengages the magnetic elements to allow the second elongate member to be directed from the retracted position towards the extended position,
wherein the first distal end terminates at a first distal tip, and wherein the magnetic elements comprise a first magnetic element on the first distal tip at least partially surrounding an outlet of the lumen and a second magnetic element on the second distal end such that when the second distal end is directed to the retracted position, the second magnetic element abuts the first distal tip, and
wherein the second elongate member terminates at a second distal tip, and wherein the second magnetic element comprises an enlarged member on the second distal tip having a cross-section larger than the outlet of the lumen such that the second magnetic element contacts the first distal tip surrounding the outlet.

US Pat. No. 10,426,924

PLACEMENT AID FOR PLACING A CATHETER FOR DIABETICS

1. A placement aid for placing a catheter and a sensor wire into a body comprising:a placement device;
a replacement device with a main body, a placement needle, a catheter and a sensor wire;
wherein the replacement device is arranged in the placement device in an interchangeable and replaceable manner,
wherein the placement needle is coupled to the main body,
wherein the placement needle and the catheter are arranged with regard to each other in such a way that the placement needle is arranged within the catheter, and that a tip of the placement needle protrudes from a proximal end of the catheter along a puncturing direction so that upon placement of the catheter along the puncturing direction, the tip of the placement needle penetrates a skin in order to produce a skin opening through which the catheter can be guided up to a subcutaneous end position, and
wherein the sensor wire is coupled to the placement needle in such a way that upon placement of the catheter along the puncturing direction, the sensor wire is arranged in the placement needle and that, upon reaching the subcutaneous end position of the catheter, the placement needle can be removed from the catheter against the puncturing direction and the sensor wire remains in the catheter; and
a holding-down rod which is arranged in the placement needle in a displaceable manner,
wherein the holding-down rod is designed to frictionally press the sensor wire against the placement needle, and
wherein the holding-down rod is further arranged at the main body in a movable manner along the puncturing direction such that, upon placement of the catheter along the puncturing direction, the placement needle, the sensor wire and the holding-down rod can jointly be advanced up to the subcutaneous end position of the catheter and such that, upon reaching the subcutaneous end position of the catheter, the holding-down rod can be withdrawn from the catheter against the puncturing direction.

US Pat. No. 10,426,923

CATHETER TIP ASSEMBLED WITH A SPRING

Medinol Ltd., Tel Aviv (...

20. A flexible catheter, comprising:a longitudinal catheter body extending from a proximal end to a distal end; and
a flexible catheter tip located at said distal end of said longitudinal catheter body, said flexible catheter tip including a spring element having a proximal end and a distal end that is a distal-most end of the flexible catheter, said spring element defining an inner lumen having n inner luminal diameter and an outer diameter;
wherein said spring element is a wire coil having pitch space between two or more coils in a first region and tightly packed coils in a second region, said second region being distal of said first region,
wherein said wire coil having a decreasing cross-sectional diameter from the proximal end of the spring element to the distal end of the spring element, and
wherein said inner luminal diameter tapers at a lesser rate than the outer diameter of the spring element.

US Pat. No. 10,426,922

MEDICAL APPARATUS AND METHOD OF MAKING THE SAME

1. A catheter assembly comprising:a catheter having a proximal end and a distal end;
an expandable device releasably attached to the catheter near the distal end, wherein the expandable device is maintained in a compressed state for endoluminal delivery;
a tip fixedly secured to the distal end of and generally coaxial with the catheter; and
a bridge member generally coaxial with the catheter and disposed in a gap between the expandable device and the tip, the bridge member being positioned distally to the expandable device and axially compressed between the tip and the expandable device such that the bridge member fills the gap between the expandable device and the tip with the expandable device maintained in the compressed state, such that the bridge member is configured to fill the gap between the expandable device and the tip during endolum inal delivery of the catheter assembly.

US Pat. No. 10,426,920

INTEGRATED CATHETER SYSTEM

BOSTON SCIENTIFIC SCIMED,...

1. A guide catheter, comprising:an inner layer defining a lumen extending therethrough;
a reinforcing braid disposed about the inner layer, the reinforcing braid comprising a plurality of wires interwoven with each other in an alternating over and under fashion;
a plurality of steering wires interwoven through the reinforcing braid; and
an outer layer disposed about the reinforcing braid;
wherein at least a portion of the reinforcing braid is embedded within the outer layer.

US Pat. No. 10,426,919

SYSTEMS AND METHODS FOR INDUCING NEGATIVE PRESSURE IN A PORTION OF A URINARY TRACT OF A PATIENT

Strataca Systems Limited,...

1. A system for inducing negative pressure in a portion of a urinary tract of a patient, the system comprising:(a) a ureteral catheter comprising a distal portion configured for insertion within the patient's kidney and a proximal portion;
(b) a bladder catheter comprising a distal portion configured for insertion within the patient's bladder and a proximal portion for application of negative pressure, the proximal portion configured to extend outside of the patient's body; and
(c) a pump external to the patient's body for application of negative pressure through both the bladder catheter and the ureteral catheter, which in turn causes fluid from the kidney to be drawn into the ureteral catheter, through both the ureteral catheter and the bladder catheter, and then outside of the patient's body.

US Pat. No. 10,426,918

FLUSHABLE CATHETERS

Hollister Incorporated, ...

1. A catheter assembly comprising:a catheter shaft having proximal and distal end portions; and
a funnel assembly fixedly secured to the distal end portion of the catheter shaft, wherein
a drainage portion is defined through the funnel assembly and the funnel assembly includes
a groove along at least a portion of an outer perimeter of the funnel assembly and/or
a shaft channel defined through the funnel assembly, with the groove and/or the shaft channel being configured to receive at least a portion of the catheter shaft for securing said at least a portion of the catheter shaft to the funnel assembly for disposal,
the drainage portion is positioned between a pair of lateral portions,
each lateral portion includes a front face and a rear face, and
the groove is defined between the front and rear faces.

US Pat. No. 10,426,917

SYSTEM AND METHOD FOR MANUFACTURING VARIABLE STIFFNESS CATHETERS

Stryker Corporation, Kal...

1. A system for manufacturing a catheter, comprising:a first material feeder coupled to a first material source;
a second material feeder coupled to a second material source;
a thermally controlled mixer coupled to the first and second material feeders, wherein the first material feeder is configured to feed a first material from the first material source into the mixer at a first material feed rate, and the second material feeder is configured to feed a second material from the second material source into the mixer at a second material feed rate, such that the first and second materials are combined in the mixer to form a compound material that varies in content as a function of the respective first and second materials, and of the first and second material feed rates;
a catheter formation mandrel having a longitudinal axis, the mandrel being controllably rotatable about the longitudinal axis at a mandrel rotation rate;
an extruder operatively coupled to the mixer and having an output nozzle configured to apply compound material from the mixer onto the catheter formation mandrel; and
a control system comprising one or more processors that control one or more of the first material feed rate, second material feed rate, and mandrel rotation rate, respectively, so as to enable formation of a catheter having a variable stiffness profile along a length of the catheter,
wherein the extruder is configured to apply an extrusion of compound material from the mixer onto the catheter formation mandrel such that the extrusion winds around the mandrel forming adjacent loops of compound material on the catheter formation mandrel.

US Pat. No. 10,426,916

METHOD OF USING AUTONOMIC NERVE FLUCTUATIONS AND SYSTEM USING THE SAME

PANASONIC INTELLECTUAL PR...

1. A method comprising:obtaining, by a processor and from a camera, information about a period of a fluctuation cycle in an autonomic nerve of a user; and
causing, by the processor, to repeat, in a same period as the period of the fluctuation cycle in the autonomic nerve, a process that includes inducing a point of gaze of the user to move along an optical axis of the user in a direction away from the user, and inducing the point of gaze of the user to move along the optical axis of the user in a direction to approach the user, according to the obtained information;
wherein
the period of the fluctuation cycle in the autonomic nerve is a period of a fluctuation cycle in a diameter of a pupil of the user.

US Pat. No. 10,426,915

SURGICAL INSTRUMENT HAVING AN INTEGRATED LOCAL ANESTHETIC DELIVERY SYSTEM

1. A surgical instrument configured for locally delivering anesthetic while implanting a mechanism configured for treating female urinary incontinence, the surgical instrument comprising:a handle portion defining a reservoir;
a longitudinally curved sling- and anesthetic-delivery incising tube in fluid communication with the reservoir, and configured to:
form a path in the abdomen of the patient;
move a sling through pelvic fascia of the patient; and
position the sling between the patient's urethra and vaginal wall;
an anesthetic delivery actuator that is connected to a biasing member, in ratcheting engagement with a plunger disposed within the reservoir and configured to move the anesthetic delivery actuator; an actuator guard disposed on the handle portion and configured to prevent inadvertent actuation of the anesthetic delivery actuator;
the biasing member;
the plunger; a local anesthetic inlet tube that is partially housed within the handle portion, terminates at an inlet port sealed by a valve cap that provides pressure release without fluid release, and is in fluid communication with the reservoir; and
the valve cap;
wherein:
the surgical instrument is configured to locally deliver the anesthetic while assisting the surgeon with forming the path through, moving the sling within, and implanting the sling in, the patient's abdomen.

US Pat. No. 10,426,914

SYSTEM AND METHOD FOR ADJUSTING HUMIDIFICATION DURING PRESSURE SUPPORT THERAPY

KONINKLIIKE PHILIPS N.V.,...

1. A pressure support system configured to adjust humidity and/or temperature of a pressurized flow of breathable gas delivered to a subject, the pressure support system comprising:a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
a humidifier configured to humidify the pressurized flow of breathable gas;
one or more sensors configured to generate output signals conveying information related to one or more parameters of the pressurized flow of breathable gas;
a user interface configured to receive entry and/or selection of feedback information from the subject indicating a comfort level with the pressurized flow of breathable gas; and
one or more physical computer processors configured by computer readable instructions to:
control the pressure generator and the humidifier to deliver the pressurized flow of breathable gas to the subject according to a predetermined therapy regime based on the output signals;
receive feedback information entered and/or selected through the user interface;
make an automatic adjustment to the pressurized flow of breathable gas to enhance the comfort level of the subject, the automatic adjustment based on the received feedback information and the output signals, the automatic adjustment including adjustment of one or more of the pressure generator or the humidifier;
receive additional feedback information entered and/or selected through the user interface subsequent to the automatic adjustment; and
prompt the subject to manually adjust one or more of the pressure generator, the humidifier, or an ambient environment based on the additional feedback information.

US Pat. No. 10,426,913

APPARATUS AND METHOD FOR MONITORING NITRIC OXIDE DELIVERY

Mallinckrodt Hospital Pro...

1. An apparatus to deliver therapeutic gas to a patient, the apparatus comprising:a first inlet to be placed in fluid communication with a therapeutic gas supply providing a continuous flow of nitric oxide at a therapeutic gas supply concentration;
a second inlet to be placed in fluid communication with a breathing gas delivery system providing a continuous flow of a breathing gas to the patient;
a therapeutic gas injector module to be placed in fluid communication with the first inlet and the second inlet to provide a combined continuous flow of breathing gas and therapeutic gas;
an outlet in fluid communication with the therapeutic gas injector module to supply the combined continuous flow of breathing gas and therapeutic gas to the patient;
a control circuit including a first flow sensor to measure the continuous flow of breathing gas from the breathing gas delivery system and a second flow sensor to measure the continuous flow of therapeutic gas, wherein the control circuit determines a calculated dose of nitric oxide based on the measured flow of breathing gas and either the measured flow of therapeutic gas or a known continuous flow of therapeutic gas; and
a display in communication with the control circuit that provides a visual and/or numeric indication of the calculated dose of nitric oxide, wherein the visual and/or numeric indication of the calculated dose of nitric oxide is provided as a percentage of a desired delivery concentration to be delivered to the patient, wherein the desired delivery concentration is set by a user; and
wherein the visual and/or numeric indication of the calculated dose of nitric oxide as the percentage of the desired delivery concentration is indicated on the display as being in one of a target delivery region, an under-delivery of nitric oxide region, and an over-delivery of nitric oxide region.

US Pat. No. 10,426,912

ZONE HEATING FOR RESPIRATORY CIRCUITS

17. A medical tube comprising:a first segment comprising one or more heater wires;
a second segment comprising one or more heater wires;
a connection circuit adapted to connect the first and second segments, the connection circuit comprising a diode; and
a controller,
wherein each of the first and second segments further comprises a spirally wound elongate hollow body and a spirally wound elongate bead member, the spirally wound elongate hollow body forming at least in part an elongate tube comprising a longitudinal axis and a lumen extending along the longitudinal axis, the elongate bead member forming at least a portion of the lumen and providing support for the elongate hollow body, and
wherein the controller is adapted to selectively switch between a first mode in which the controller provides power to the first segment, and a second mode in which the controller provides power to the first and second segments,
wherein a heater circuit comprising the one or more heater wires of the first and second segments is independent of another heater circuit that heats another tube.

US Pat. No. 10,426,911

RESPIRATORY THERAPY CONDENSATION ADAPTOR

VAPOTHERM, INC., Exeter,...

1. An adaptor for coupling a tracheostomy tube to a source of humidified breathing gas, the adaptor comprising:a housing having an interior surface, an exterior surface, and a breathing gas port for receiving a flow of humidified breathing gas from the source, the breathing gas port extending from the exterior surface to the interior surface;
a tracheostomy tube connection device positioned within the housing, the tracheostomy tube connection device including an input port for receiving the flow of humidified breathing gas from the breathing gas port and an output port for coupling with the tracheostomy tube, the tracheostomy tube connection device having an internal surface defining a breathing gas passage and an external surface spaced from the interior surface of the housing to create a condensation passage wherein the condensation passage comprises a bottom end, and wherein the condensation passage is configured such that condensation flows towards the bottom end and exits the adaptor;
a baffle positioned between the breathing gas port and the input port to cause controlled condensation from the flow of humidified breathing gas by disrupting the flow of humidified breathing gas; and
at least one projection, positioned within the housing, to space the tracheostomy tube connection device from the interior surface of the housing.

US Pat. No. 10,426,910

CUSHION FOR MASK SYSTEM

ResMed Pty Ltd, Bella Vi...

1. A patient interface for providing a supply of pressurized air to a patient to treat Sleep Disordered Breathing (SDB) with Continuous Positive Airway Pressure (CPAP), the patient interface comprising:a rigid frame;
a soft cushion attached to the rigid frame, the soft cushion further comprising:
a nasal portion configured to seal at the patient's nose, the nasal portion further comprising at least one opening configured to direct the supply of pressurized air to the patient's nasal passages; and
a mouth portion configured to seal around the patient's mouth, the perimeter of the mouth portion further comprising a side wall, the mouth portion further comprising a membrane extending from the side wall and configured to seal with the patient's face, and the membrane forming an aperture configured to receive the patient's mouth and direct the supply of pressurized air to the patient's mouth;
an elbow assembly configured to connect the patient interface to an air delivery conduit; and
a headgear assembly configured to hold the rigid frame and the soft cushion in position on the patient's face,
wherein a flexible section of the perimeter of the mouth portion is relatively more flexible than the remainder of the mouth portion, and
wherein the side wall at the flexible section has a reduced thickness relative to the side wall around the remainder of the perimeter of the mouth portion.

US Pat. No. 10,426,909

NASAL RESPIRATORY ASSEMBLY AND METHODS OF USE

1. A nasal respiratory assembly for delivering a therapeutic treatment to a patient comprising:a) a mask having a top surface and a base, wherein said mask is configured with an exhaust port having a one-way valve positioned on said top surface;
b) a first rotatable intake port and a second rotatable intake port positioned on either side of said top surface, wherein said first and said second rotatable intake ports further comprises a directing means that directs pressurized gas from entering said patient's nasal cavities directly, and wherein said directing means is one or more louvered vents;
c) a hose having a first end and a second end adapted to be received by said first and second intake ports, and at least a third end; and
d) a rotatable medication delivery port provided on said hose and positioned proximal to at least one of said intake ports; and
wherein said therapeutic treatment is not delivered directly into the patient's nasal cavities.

US Pat. No. 10,426,907

METHOD AND SYSTEM FOR CONTROLLING A DRUG DOSING DEVICE

1. A method for controlling a drug dosing device for administering a drug to a patient, the method comprising:determining a quantity of the drug administered to the patient from the drug dosing device via a drug quantity determination device;
measuring a concentration of the drug in the gas exhaled by the patient as a first patient value via a concentration determining device;
providing a control system configured for:
carrying out a simulation calculation, in which a second patient value is calculated from the administered quantity of the drug, taking into account a parameter;
calculating a simulated first patient value in the simulation calculation, taking into account the parameter;
comparing the simulated first patient value to the measured first patient value;
adapting the parameter on the basis of the comparison; and
generating a control signal based on the second patient value, wherein the drug dosing device adapts the quantity of the drug administered to the patient based on the control signal, wherein the simulation calculation comprises a compartment model carried out based on:
blood circulation forming a first compartment;
a second compartment being taken into account, for which a concentration of the drug is calculated;
a third compartment being taken into account, for which a concentration of the drug is calculated;
the drug passing from the first compartment into the second compartment at a first rate;
the drug passing from the second compartment into the first compartment at a second rate;
the drug passing from the first compartment into the third compartment at a third rate;
the drug passing from the third compartment into the first compartment at a fourth rate;
the concentration of the drug in the breathing gas forming the first patient value being calculated such that a passage of the drug from the first compartment into the breathing gas takes place at a breathing gas rate; and
the drug being broken down from the first compartment at an elimination rate, which is the parameter, wherein the simulation calculation is carried out such that a passage of the drug from the lung into the breathing gas is calculated by a time lag element of the first order, so that an equation:
?1+k10·c1=K·k10·cp applies to the concentration (c1) of the drug in the breathing gas and a change to the concentration over time (?1), wherein cp is the concentration of the drug in the blood circulation and K and k10 are constants.

US Pat. No. 10,426,906

VENTILATOR MONITORING AND CONTROL

Mayo Foundation for Medic...

25. A computer-implemented patient information provisioning system, comprising:one or more mechanical ventilators for treating patients in a healthcare facility;
an interface operating on a computer processor system programmed to identify, as key words, terms likely to occur in electronic medical records that are determined to indicate presence of acute lung injury or acute respiratory distress syndrome, and obtain (a) data about operating parameters of the one or more mechanical ventilators, including information about the location(s) of the one or more mechanical ventilators, (b) information for electronically contacting particular caregivers who correspond to patients served by the one or more mechanical ventilators and are identified for contact based on a determination of what caregiver is currently assigned responsibility for a location in the healthcare facility that currently needs action by a caregiver, and (c) data from a central electronic medical records system operated by the healthcare facility, wherein the patient information provisioning system is programmed to automatically query written textual descriptions by caregivers in electronic medical records of the electronic medical record system to determine whether trigger terms in the records indicate that one or more particular patients under care have acute lung injury or acute respiratory distress syndrome;
an electronic patient evaluator to use the data about the current operating parameters of the one or more mechanical ventilators and the data from the central electronic medical records system to
(1) adjust an operational value for a first mechanical ventilator, of the one or more mechanical ventilators, from a normal value that is used for patients who do not have acute lung injury or respiratory distress syndrome, based on determining that a dangerous condition exists for a first patient as a combination of
(a) the first patient's electronic medical record having one or more key words that are indicative of acute lung injury or acute respiratory distress syndrome, and
(b) the first mechanical ventilator having a current value inconsistent with treatment of someone with acute lung injury or acute respiratory distress syndrome;
(2) determine that a potentially dangerous condition exists for the first patient based on a measured value for the first mechanical ventilator being excessive compared to the adjusted operational value; and
(3) identify that the first patient is receiving an inappropriate low tidal volume from the first mechanical ventilator by determining that a measured value for the first mechanical ventilator is excessive compared to the adjusted operational value; and
an alert module to provide, for transmission to one or more caregivers who are remote from the first mechanical ventilator, a notification of the identified dangerous condition.

US Pat. No. 10,426,905

METHODS AND SYSTEMS FOR IMPROVING AIRWAY PATENCY

SOMNICS, INC., Zhubei, H...

17. Apparatus for improving airway patency of a patient having an oral cavity, a hard palate, a soft palate, a tongue, lips, and an airway, the apparatus comprising: an oral device positionable in the oral cavity, the oral device comprising one or more ports through which negative pressure is applied to provide a continuous pathway for pressure delivery from the lips to the soft palate when the oral device is placed in the oral cavity, wherein the oral device is configured to apply negative pressure to generate a seal between the soft palate and a posterior region of the tongue to isolate the airway from the oral cavity, and wherein the oral device comprises a tongue constraint having a superior surface and an inferior surface, the surfaces being configured to maintain a clear region between a medial region of the tongue and the hard palate.

US Pat. No. 10,426,904

VOLUME REFLECTOR STATUS INDICATOR FOR ANESTHESIA SYSTEM

Maquet Critical Care AB, ...

1. An anesthesia system having a volume reflector, a breathing circuit, a processing unit, and a display operatively connected to said processing unit, wherein said processing unit is configured to provide a status indicator on said display for gas in said volume reflector, said status indicator including a real-time graphical representationof a driving gas of said volume reflector and a patient gas in said volume reflector; and
a flow of gas and a direction of said flow in said volume reflector;
wherein said status indicator comprises a graphical representation of adjacent gas pillars representing said driving gas and said patient gas in operation in said volume reflector, and said graphical representation further includes a representation of a present extent of said driving gas pillar and said patient gas pillar in said volume reflector during both an inhalation and an exhalation of a breathing cycle.

US Pat. No. 10,426,903

AUTOMATIC TRIGGER MODULE AND ELECTRONIC CIGARETTE THEREOF

JOYETECH EUROPE HOLDING G...

4. An electronic cigarette, comprising:an automatic trigger module, comprising:
a sensor, having a first end and a second end which are opposite to each other;
a circuit board, having a first vent hole communicating with the first end of the sensor and a first connection;
a sealing seat, having a second vent hole communicating with the second end; and
a control board, having a second connection,
wherein the first end is located on the circuit board, and the second end is located in the second vent hole, and
wherein the automatic trigger module is detachably connected to the control board, and when the automatic trigger module is connected to the control board, the first connection and the second connection contact with each other to realize a transmission of signal.

US Pat. No. 10,426,902

SYSTEMS FOR LAPAROSCOPIC SURGERY

1. A surgical humidification apparatus comprising:a heater base configured to contact a humidification chamber in use, the humidification chamber adapted to hold a volume of water and having an inlet and an outlet, the inlet in fluid communication with a gases source to receive gases from the gases source in use, the heater base configured to heat the water in the humidification chamber to create vapor to humidify gases passing through the humidification chamber from the inlet to the outlet in use; and
a controller configured to determine a low water or a no water condition of the humidification chamber based at least in part on an increase in power supplied to the heater base.

US Pat. No. 10,426,901

SYRINGE CAP HAVING REUSE PREVENTION STRUCTURE

1. A syringe cap having a reuse prevention structure, the syringe cap comprising:a fixed body (20) with a spiral protrusion (22) on an inner circumferential surface thereof, into which a dispensing tip (11) of a syringe barrel (10) is fitted, and whose bottom is coupled to the syringe barrel (10) by a fusion welding portion (21);
a separable body (30) with a spiral groove (31) on a lower part of an outer circumferential surface thereof, the spiral groove (31) being spirally engaged with the spiral protrusion (22) provided on the inner circumferential surface of the fixed body (20);
a rubber packing (40) fitted in the separable body (30) to seal and block the dispensing tip (11) of the syringe barrel (10) coupled to the fixed body (20); and
a reuse prevention cover (50) fitted over the fixed body (20) and the separable body (30) to cover the fixed body (20) and the separable body (30),
wherein the reuse prevention cover (50) includes:
an upper body (51) fitted over the separable body (30) to cover an outer surface of the separable body (30);
a lower body (52) fitted over the fixed body (20) to cover an outer surface of the fixed body (20), and positioned below a lower end of the upper body (51) such that a top of the lower body (52) is spaced apart from a bottom of the upper body (51); and
a connection breakable portion (53) which integrally connects the upper body (51) and the lower body (52) by connecting the bottom of the upper body (51) to the top of the lower body (52), and is broken by rotating the upper body (51) relative to the lower body (52) in a direction to separate the bottom of the upper body (51) from the top of the lower body (52), such that the separable body (30) covered with the upper body (51) is separated from the fixed body (20) to open the fixed body (20), and
wherein the spiral protrusion (22) of the fixed body (20) includes a tapered first pushing slope (23), and the spiral groove (31) of the separable body (30) includes a second pushing slope (32) corresponding to the first pushing slope (23) such that when rotating the upper body (51) of the reuse prevention cover (50) in one direction relative to the lower body (52) in a state of pushing the upper body (51) toward the lower body (52), the upper body (51) is pushed up by the lower body (52), thereby being easily broken due to breaking of the connection breakable portion (53) connecting the upper body (51) and the lower body (52) to each other.

US Pat. No. 10,426,900

AUTOMATIC INJECTION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A method for measuring an amount of pain comprising:positioning a needle adjacent a non-human animal which is under anesthesia;
automatically inserting the needle at a controlled puncture speed into skin of the non-human animal by an automatic needle puncture device; and
measuring a muscle action potential of a muscle portion of the non-human animal produced by the insertion of the needle, the muscle action potential being measured from insertion start, at which the insertion of the needle into the skin is started, to insertion stop, at which the insertion of the needle into the skin is stopped,
whereby the measured muscle action potential indicates a measurement of the amount of pain.

US Pat. No. 10,426,899

MEDICAL DEVICE ASSEMBLY

Becton, Dickinson and Com...

1. A medical device assembly comprising:a fluid storage container having a visual indicator including three separate colored strips comprising a first colored stripe disposed closest to an opening of the fluid storage container, a second colored stripe disposed proximally adjacent to the first colored stripe, and a third colored stripe disposed proximally adjacent to the second stripe;
a device having a hub including a sidewall having an inside surface defining a cavity, an open proximal end, and a distal end having an opening therethrough in fluid communication with the cavity; the hub of the device attaches to the fluid storage container;
a first indicating element having a distal end attached to the distal end of the hub and a free proximal end extending into the cavity, the first indicating element forming a peripheral recess with the sidewall of the hub; and
a second indicating element disposed in the cavity of the hub including an open proximal end, an open distal end and a body extending from the open proximal end of the second indicating element to the open distal end, the body having an inside surface defining a hollow interior for enveloping the first indicating element to permit the body to enter the recess of the hub upon application of a force to the hub in a proximal direction relative to the fluid storage container, wherein the hub attaches to the fluid storage container such that visibility of the second stripe and the third stripe indicates optimal engagement of the hub to the fluid storage container.

US Pat. No. 10,426,898

RETRACTABLE NEEDLE ASSEMBLIES

Owen Mumford Limited, (G...

1. A retractable needle assembly comprising:a body portion;
a needle having a patient end and being movable between an operational position in which the needle extends along a longitudinal needle axis with the patient end projecting forwardly from the body portion, and a safe position in which the patient end is retracted into the body portion;
a deflector element rotatable about a deflector rotary axis generally perpendicular to the longitudinal needle axis to move the needle to its safe position, and
a manually operated deflector lever connected to or forming part of the deflector element, the manually operated deflector lever projecting from the body portion and intersecting a plane perpendicular to the deflector rotary axis and containing the longitudinal needle axis, the manually operated deflector lever rotates about the deflector rotary axis, from a first position perpendicular to the longitudinal needle axis to a second position parallel to the longitudinal needle axis, to fully retract the needle.

US Pat. No. 10,426,897

CONTAINER HOLDER ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE AND MEDICAMENT DELIVERY DEVICE COMPRISING THE CONTAINER HOLDER ASSEMBLY

Carebay Europe LTD, Slie...

1. Container holder assembly for a medicament delivery device, which container holder assembly comprises;a housing part, fixedly mounted relative to a longitudinally elongated housing;
a container holder for accommodating a medicament container, which container holder is longitudinally movable relative to the housing part from a distal, initial position to a proximal, end position;
a spring-biased needle guard, coaxial with the container holder and releasably connected with the container holder, and longitudinally movable relative to the housing part between an extended position and a retracted position;
wherein the housing part is coaxially arranged between the container holder and the needle guard,
wherein the housing part comprises a first longitudinal slit through which the needle guard is connected with the container holder,
wherein the needle guard is connected with the container holder by a first connecting member of the needle guard radially biasing a resilient second connecting member of the container holder,
wherein the needle guard is configured to disconnect from the container holder upon movement from the extended position to the retracted position, and
wherein, when the needle guard is connected to the container holder, the second connecting member is radially biased into engagement with a holding member of the housing part, such that the container holder is prevented from longitudinal movement relative to the housing part.

US Pat. No. 10,426,896

MEDICINE INJECTION AND DISEASE MANAGEMENT SYSTEMS, DEVICES, AND METHODS

Bigfoot Biomedical, Inc.,...

1. A pen cap for an insulin pen comprising:one or more sensors adapted to detect a position of a plunger within the insulin pen;
a user interface comprising one or more user-selectable icons or buttons adapted to announce a meal or an intent to have a meal;
a sensor adapted to detect a characterization of the insulin pen or a type of insulin in the insulin pen;
a memory to store information about different types of insulin pens or different types of insulin; and
a processor to determine the type of insulin pen or the type of insulin, wherein the processor is configured to change the user interface dependent on the type of insulin pen or the type of insulin, wherein some types of insulin or insulin pens result in a user-interface that does not include any user-selectable icons or buttons adapted to announce a meal or an intent to have a meal.

US Pat. No. 10,426,895

DRIVE MECHANISM AND DRUG DELIVERY DEVICE HEREWITH

Sanofi, Paris (FR)

1. A drive mechanism for a drug delivery device, the mechanism comprising a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member into a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member when in a decoupled state, and a spring biasing the clutch into the coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring, wherein the clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction, wherein the drive member is formed of polybutylene terephthalate (PBT), polyoxymethylene (POM), or polycarbonate (PC) and the rotatable driven member is formed of PBT, POM or PC, and a coefficient of friction (?) between the teeth on the drive member and the teeth on the driven member is between 0.05 and 0.3, and the teeth on the drive member and the teeth on the driven member have a surface roughness (Ra) of 0.2?Ra?10 micrometers.

US Pat. No. 10,426,894

DRUG DELIVERY DEVICE WITH INDICATOR

INSULET CORPORATION, Act...

1. An apparatus, comprising:a drug container configured to hold a liquid drug;
a plunger positioned in the drug container;
a drive system coupled to the plunger, the drive system configured to advance the plunger to expel a portion of the liquid drug from the drug container for delivery to a patient, the drive system comprising one or more spherical elements and a drive spring;
a Hall effect sensor positioned adjacent to the drug container; and
a controller coupled to the Hall effect sensor,
wherein the Hall effect sensor is configured to measure a varying magnetic field caused by the one or more spherical elements passing the Hall effect sensor,
wherein the Hall effect sensor is configured to generate a signal indicative of the measured varying magnetic field,
wherein the controller receives the signal generated by the Hall effect sensor and determines a count of a number of the one or more spherical elements that pass the Hall effect sensor.

US Pat. No. 10,426,893

DRUG DELIVERY DEVICE WITH THREADED HOUSING AND PISTON, AND METHOD FOR MANUFACTURING THE SAME

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising: a housing defining a longitudinal axis and having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face, wherein the bearing comprises a retaining stem protruding from the proximal face, wherein the piston rod comprises a distal portion having an outer diameter which is smaller than an inner diameter of the inner thread of the tubular portion, and, a retaining clip engaging the retaining stem at a distal end of the piston rod, and wherein an axial length of the tubular portion is smaller than or equal to an axial distance between the proximal face of the bearing and the distal end of the threaded portion of the piston rod.

US Pat. No. 10,426,892

MOTORIZED DRUG DELIVERY DEVICE

SHL Medical AG, Zug (CH)...

1. A motorized drug delivery device configured to administer at least one pre-set dose of a medicament contained within a medicament container, the delivery device comprising:a user activation system;
a motor;
a gear train operatively coupled to the user activation system and the motor;
a piston plunger system operatively coupled to the gear train, the piston plunger system comprising a piston plunger and at least one plunger extension for extending a length of the piston plunger;
wherein the piston plunger system is configured to act on a stopper contained within the medicament container to deliver at least one pre-set dose of medicament,
wherein the user activation system comprises a mechanical automatic reset activation system that automatically resets the drug delivery device after administration of the pre-set dose, and wherein the mechanical automatic reset activation system includes a dispense button operatively coupled to a hook release.

US Pat. No. 10,426,891

DISPOSABLE CASSETTE FOR STORING AND DELIVERING A MEDICAL DRUG

1. An injector device comprising:a housing defining a cavity having a disposable cassette arranged therein, said housing comprising a movable lid allowing the disposable cassette to be inserted into or removed from the cavity,
a movable sledge configured to operate a valve block of the disposable cassette arranged in the cavity, and
a plunger activator arranged in abutment with a plunger of a cartridge of the disposable cassette arranged in the cavity, the plunger activator being configured to operate the plunger in order to cause a medical drug to be delivered,
wherein the disposable cassette comprises:
the cartridge containing the medical drug,
a waste reservoir arranged to receive waste liquid and/or gas,
an injection needle or an injection needle mounting interface for mounting an injection needle arranged to deliver the medical drug, and
the valve block being movable between a first position and a second position, the first position establishing a fluid passage between the cartridge and the waste reservoir, while preventing fluid flow from the cartridge to the injection needle or the injection needle mounting interface, and the second position establishing a fluid passage between the cartridge and the injection needle or the injection needle mounting interface, while preventing fluid flow from the cartridge to the waste reservoir,
wherein the cartridge, the waste reservoir, the valve block and at least part of the injection needle or the injection needle mounting interface are arranged inside a cassette housing of the disposable cassette, and wherein the valve block is operable to be moved between the first position and the second position without a user operating the disposable cassette coming into direct contact with parts arranged inside the cassette housing.

US Pat. No. 10,426,890

DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drug delivery device comprising:a primary drug delivery assembly with a primary dose dial sleeve configured to move proximally in a helical movement during setting of a dose of a primary medicament contained in a primary reservoir of the primary drug delivery assembly and a secondary drug delivery assembly with a secondary drive sleeve configured to move in a proximal direction in a helical movement during setting of a dose of a secondary medicament contained in a secondary reservoir of the secondary drug delivery assembly
a selection switch movable between a first position, a second position, and a third position, wherein the first position is an intermediate position between the second position and the third position; and
a clutch connected to the selection switch such that movement of the selection switch causes rotation of the clutch,
wherein the clutch is configured to engage with and to transfer rotation to the secondary drive sleeve when the selection switch is moved from the first position into the second position such that the dose of the secondary medicament is set and to disengage from the secondary drive sleeve when the selection switch is moved from the first position into the third position such that the dose of the secondary medicament is not set, and
wherein a first engagement element is configured to rotate the primary dose dial sleeve in one direction to set the dose of the primary medicament, wherein the first engagement element is adapted to be engaged by the selection switch such that movement of the selection switch from the first position into the second position and from the first position into the third position causes the first engagement element to rotate the primary dose dial sleeve in the one direction such that a predetermined dose of the primary medicament is set.

US Pat. No. 10,426,889

OPTICAL DISPLACEMENT SENSOR FOR INFUSION DEVICES

DEKA PRODUCTS LIMITED PAR...

1. A medical fluid dispensing apparatus for pumping an infusible medical fluid to the body of a patient, the medical fluid dispensing apparatus comprising:a piston having an encoded pattern associated therewith; and
an optical sensor, wherein the optical sensor is configured to determine the position of the piston, relative to a fiducial position based on the encoded pattern during delivery regardless of whether the encoded pattern associated with the piston repeats.

US Pat. No. 10,426,888

METHOD AND SYSTEM FOR DOSE RATE REGULATION IN DRUG INFUSION TREATMENT

PHARMACOLOG I UPPSALA AB,...

1. A system for administering a drug solution by infusion, comprising:a drug container (1, 2) containing a label drug solution with a label concentration of a drug,
a drug delivery set comprising a fluid conduit (4, 6) connected to the drug container (1, 2), means for connecting the fluid conduit (4, 6) to a patient (8), a detection chamber in the fluid conduit (4, 6) between the drug container (1, 2) and the patient connection means, and adjustment means for setting an infusion rate corresponding to a predetermined dose rate of the drug based on the label concentration,
analytical detection means (5) for non-invasive determination in the detection chamber of the identity and concentration of the drug in fluid withdrawn from the drug container into to the fluid conduit, and
means (7) for preventing infusion of drug solution from the drug container if the label drug is not identified, and
a control unit (10) arranged to control the adjustment means and configured to calculate and set the adjustment means to an adjusted infusion rate in order to maintain the predetermined dose rate when the drug concentration determined in the detection chamber deviates from the label concentration of the drug,wherein said system further comprises a blood analysis system to measure the biological response to the actual dose rate, wherein information obtained therefrom is used as a variable in the dose rate setting.

US Pat. No. 10,426,886

SET OF CONTAINERS FOR USE ON A BLOOD COMPONENT CENTRIFUGAL SEPARATOR

Terumo Kabushiki Kaisha, ...

1. A disposable set of containers for use on a blood component centrifugal separator, said blood component centrifugal separator having a first pump, a second pump and a centrifuge rotor, the disposable set comprising:a separation container adapted to be mounted on the centrifuge rotor and having an inlet port and an outlet port;
a tube in fluid communication with a source of whole blood drawn from a blood donor and in further fluid communication with the separation container and adapted to engage the first pump,
a first container for receiving a predetermined first blood component, among centrifugally separated blood components, together with whole blood, said first container being in fluid communication with the outlet port of said separation container and with the inlet port of said separation container, and
a second tube adapted to engage the second pump and in fluid communication with said first container and said inlet port of said separation container,
a temporary storage container wherein whole blood drawn from the blood donor is temporarily stored, and
a third tube coupled to the temporary storage container further coupled to the outlet port of the separation container and a fourth tube also coupled to the temporary storage container and further coupled between the first container and the second tube and further comprising a fifth tube in fluid communication with said third tube and said first tube such that said second tube is connected to said first tube between said fifth tube and said inlet port of said separation container.

US Pat. No. 10,426,885

METHODS AND SYSTEMS FOR ESTABLISHING RETROGRADE CAROTID ARTERIAL BLOOD FLOW

Silk Road Medical, Inc., ...

1. A system for use in accessing and treating a carotid artery, said system comprising:an arterial access sheath formed of an elongated body sized and shaped to be introduced into a common carotid artery, the arterial access sheath having an internal lumen that can receive blood flow;
a shunt that fluidly communicates with the arterial access sheath, wherein the shunt provides a pathway for blood to flow from the arterial access sheath; and
a flow control assembly mechanically attached to the pathway of the shunt, wherein the flow control assembly defines two or more parallel flow paths and a valve to open or close one or more of the flow paths to selectively direct blood flow through one or more of the flow paths.

US Pat. No. 10,426,884

CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES

Novaflux Inc., Princeton...

1. An outside-in flow filtration cartridge, comprising:a housing;
a plurality of fibers contained inside said housing, at least some of said plurality of fibers being hollow and being made of semi-permeable membranes having respective fiber lumens and fiber exteriors;
a first fluid flow compartment comprising said fiber lumens of said hollow fibers; and
a second fluid flow compartment comprising an inter fiber space bordering said fiber exteriors,
wherein said housing comprises a first housing port near a first end of said housing, and a second housing port near a second end of said housing,
wherein said second fluid flow compartment comprises an orbital distributor in communication with said inter fiber space,
wherein said outside-in flow filtration cartridge comprises a lateral-circumferential flow redirector comprising an edge, said edge being located between one of said housing ports and said plurality of fibers, said edge facing in a direction toward said one of said housing ports, wherein said lateral-circumferential flow redirector comprises a first smoothly curved concave surface that extends from said edge and blends smoothly with a first circumferential direction of said orbital distributor, and a second smoothly curved concave surface that extends from said edge and blends smoothly with a second circumferential direction of said orbital distributor, and
wherein said outside-in flow filtration cartridge is constructed to flow blood in the inter fiber space bordering said fiber exteriors.

US Pat. No. 10,426,883

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

Baxter International Inc....

1. A hemodialysis system configured to purge air from a blood circuit, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
the blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, and
a drip chamber located along the venous line; and
an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged from the blood circuit using dialysis fluid or other physiologically acceptable fluid pumped through the dialysis fluid circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly to the blood circuit.

US Pat. No. 10,426,882

BLOOD RINSEBACK SYSTEM AND METHOD

Baxter International Inc....

1. A hemodialysis system configured to return blood to a patient, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
a blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,
a drip chamber located along the venous line;
a blood detector operable with the venous line; and
a blood rinseback scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, blood is pushed to the patient via the medical fluid being introduced from its source into the arterial line between the arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber and to the blood detector along the venous line, where the medical fluid is sensed by the blood detector to indicate an end of the blood rinseback.

US Pat. No. 10,426,881

ENHANCED BACKFLOW PREVENTION IN A HEMODIALYSIS DEVICE

Fresenius Medical Care Ho...

1. A hemodialysis system, comprising:a hydrochamber adapted to heat and remove air from water and to provide backflow protection, the hydrochamber including a first inlet located at a top portion thereof and a second inlet located at a bottom portion thereof;
a water circuit for water to flow from an external water source into the hydrochamber via a water inlet valve, the water inlet valve being connected to the first inlet located at the top portion of the hydrochamber via a first fluid flow path;
a spent dialysate circuit for a disinfecting agent to flow to the hydrochamber via a recirculation valve during a disinfectant operation; and
a drain valve disposed in the spent dialysate circuit;
wherein during the disinfectant operation, the hemodialysis system is adapted to replace a volume of the disinfecting agent exiting the spent dialysate circuit via the drain valve with a substantially equal volume of water via the water inlet valve; and
wherein the recirculation valve is directly connected to the hydrochamber via a second fluid flow path connected to the second inlet located at the bottom portion of the hydrochamber, the second fluid flow path being separate and independent of the first fluid flow path such that in response to a pressure drop at the external water source, the disinfecting agent is prevented from back-flowing through the water inlet valve.

US Pat. No. 10,426,880

VENTRICULAR ASSIST DEVICE AND METHOD

MI-VAD, INC., Rochester,...

1. A ventricular assist device for a human heart comprising:a flow housing having a generally cylindrical wall with an inner surface defining a portion of a flow path, the flow housing having an outer surface and sized for placement within a blood vessel;
a stator disposable within the flow housing, the stator having a plurality of support struts operatively coupling the stator to the flow housing;
a rotor including an outer surface facing the inner surface of the cylindrical wall of the flow housing, the rotor rotatably coupled to the stator and rotatable with respect to the stator about a rotational axis, the rotor defined in part by at least one blade angled with respect to the rotational axis;
one of the rotor and the stator comprising a field magnet and the other of the rotor and the stator comprising windings;
a power source operatively coupled to the windings;
a controller operatively coupled to the power source to selectively control the power source to vary the rotational speed of the rotor; and
a vascular graft surrounding the flow housing and coupled to the flow housing, the vascular graft sized for placement within the blood vessel and arranged for coupling to the blood vessel.

US Pat. No. 10,426,879

BLOOD PUMP WITH RESTART LOCKOUT

HeartWare, Inc., Miami L...

1. A control circuit for controlling operation of an implantable blood pump, the control circuit comprising:an interface;
a pump shutdown module in communication with the interface, the interface being configured to provide one or more inputs indicating at least from the group consisting of an operational error at the implantable blood pump and an adverse physiological state of a user of the implantable blood pump, the pump shutdown module being configured to cease operation of the implantable blood pump in response to the one or more inputs;
a pump restart module configured to resume operation of the implantable blood pump in response to a first pump restart input and a second pump restart input different from the first pump restart input, the first pump restart input and a second pump restart input being provided by the interface; and
a pump restart lockout module configured to initiate a pump lockout mode in response to a lockout input provided by the interface, the pump lockout mode:
preventing resumption of operation of the implantable blood pump in response to the first pump restart input; and
allowing resumption of operation of the implantable blood pump in response to the second pump restart input.

US Pat. No. 10,426,877

BREAST MILK EXPRESSION APPARATUS AND SYSTEM

IMALAC, INC., Miami, FL ...

1. A breast milk expression apparatus comprising:an outer shell;
a plurality of circumferentially spaced inner pads coupled to the outer shell, the plurality of pads disposed under the outer shell, each pad having a radially inner concave surface configured to engage a breast of a user, and the pads configured for radial displacement, wherein each pad defines a circumferential channel extending longitudinally along a respective axis, and wherein in a configuration where the pads engage the breast of the user, the pads are disposed between the outer shell and the breast;
a compression unit coupled to the plurality of pads, configured to cyclically displace the pads radially inwardly against the breast to cause compression of the breast and, following compression of the breast, permitting the breast to expand and decompress, wherein the compression unit includes:
a cable banded about and extending longitudinally and coaxially through each circumferential channel of the plurality of pads, wherein the circumferential channels permit relative longitudinal movement of the cable relative to the pads, and
a drive unit coupled to the cable and the outer shell, the drive unit configured to tighten the cable about the pads to cause the pads to compress the breast and configured to loosen the cable about the pads, permitting the breast to expand and decompress.

US Pat. No. 10,426,876

BREST PUMP DEVICE

Vesucta ApS, Aarhus N (D...

1. A breast pump kit comprising: an electrical driving unit and a breast pump collection system, the breast pump collection system being completely separate from the driving unit and configured to be combined to the driving unit by a user, the breast pump collection system being detachable from the driving unit; wherein the breast pump collection system comprises: a breast shield for placing on a breast of a user, a pump unit, and a tubing connecting the breast shield to the pump unit, wherein the pump unit comprises a compartment of a variable volume and in fluid connection to an exterior only via the tubing, wherein the driving unit comprises at least two attachment means spaced apart by a distance that changes with a driving motion of the driving unit, and wherein the pump unit is configured to be detachably combined to the driving unit by placing the pump unit in engagement with the attachment means such that the driving motion of the driving unit acts to alternatingly expand and contract the compartment of the pump unit, the pump unit thereby creating alternating suction and pressure in the breast shield and at the breast of the user when in use; and wherein the pump unit comprises a bellows and is manufactured as a single-unit component.

US Pat. No. 10,426,875

WOUND CLEANSING APPARATUS IN-SITU

1. A negative pressure wound therapy system, comprising:a wound dressing comprising:
a backing layer comprising an opening and a proximal, wound-facing face and a distal face;
a lower permeable layer configured to contact a wound; and
a chamber between the backing layer and the lower permeable layer; and
a resiliently flexible filler positioned within the chamber, the resiliently flexible filler comprising an absorbent material configured to retain wound exudate within the chamber;
a fluid outlet conduit configured to provide fluid communication between a negative pressure source and the wound dressing, the fluid outlet conduit being in fluid communication with the chamber of the wound dressing; and
a connector attached to the backing layer and forming a seal around the opening in the backing layer, wherein the connector is configured to connect the fluid outlet conduit to the wound dressing; and
a porous material positioned in the flow path between the chamber and the negative pressure source and configured to prevent passage of the wound exudate from the chamber into the fluid outlet conduit.

US Pat. No. 10,426,874

WOUND MANAGEMENT ASSEMBLY AND NEGATIVE PRESSURE WOUND THERAPY SYSTEM

APEX MEDICAL CORP., New ...

1. A wound management assembly for promoting removal of fluid from a wound, comprising:a housing comprising an inlet portion, an outlet and a side wall;
an exudate collector received in the housing; and
a gap defined between the housing and the exudate collector to form a channel for fluid passage;
wherein the fluid passes into and through the exudate collector and radially enters the channel;
wherein the housing defines a chamber therein for receiving the exudate collector, and the inlet portion and the outlet are in communication with the chamber; and
wherein the side wall encompasses the exudate collector, and the exudate collector is surrounded by the channel.

US Pat. No. 10,426,873

EVACUATION SYSTEM

Nascent Surgical, LLC, E...

1. An evacuation system for surgical settings comprising:a vacuum source configured to generate a negative pressure for delivering a level of suction for removing smoke during open surgery;
a flow regulator device fluidly coupled to the vacuum source, the flow regulator device comprising a vacuum port, an inlet port, and a flow rate adjuster; and
a sensing and control system operatively associated with the vacuum source and the flow regulator and programmed to:
cause delivery of a first level of suction via the flow regulator device based on a target pressure level to be maintained in a body cavity during laparoscopic surgery;
sense a level of pressure at one or more of the vacuum port and the inlet port indicative of a pressure of the body cavity during laparoscopic surgery; and
cause delivery of a second level of suction via the flow regulator device in response to a sensed level of pressure deviating from the target pressure, the first and second levels of suction being non-zero suction levels,
wherein the vacuum port is adapted to fluidly couple to the vacuum source, the inlet port is adapted to fluidly couple to an end effector, the vacuum port and the inlet port are fluidly coupled, and the flow rate adjuster is operable to adjust a level of negative pressure delivered by the vacuum source to the inlet port to a reduced suction level such that the end effector receives a level of active suction for removing smoke from the body cavity during laparoscopic surgery.

US Pat. No. 10,426,872

NERVE REPAIR SCAFFOLDS HAVING HIGH MICROCHANNEL VOLUME AND METHODS FOR MAKING THE SAME

THE REGENTS OF THE UNIVER...

1. A method of making a tissue scaffold for neural tissue growth, the method comprising:admixing (i) a porogen having an average particle size of less than or equal to about 40 ?m with (ii) a polymeric precursor solution comprising a biocompatible and biodegradable polyester polymer precursor and a first solvent, to form a suspension;
contacting a template with the suspension to coat at least one surface of the template;
volatilizing at least a portion of the first solvent to form a coating;
removing the coating from the template; to create a microchannel;
assembling the microchannel inside a sheath with a plurality of other microchannels; and
removing the porogen to form a plurality of porous microchannels disposed within sheath thus creating the tissue scaffold.

US Pat. No. 10,426,871

NANOSTRUCTURE SURFACE COATED MEDICAL IMPLANTS AND METHODS OF USING THE SAME

The Regents of the Univer...

1. A method comprising administering to a subject a composition that comprises a surface or film comprising a vertically oriented array of a plurality of nanotubes or microwells,wherein a bioactive agent is filled into the nanotubes or microwells themselves,
wherein a first end of the array of the plurality of filled nanotubes or microwells is in contact with the surface or film, and
wherein the plurality of nanotubes or microwells is capped with a polymeric erodible capping film to provide for delayed elution of the bioactive agent from within the nanotubes or microwells to the surrounding tissue upon placement in a subject and erosion of the capping film.

US Pat. No. 10,426,870

BIOMATERIALS FOR ENHANCED IMPLANT-HOST INTEGRATION

THE TRUSTEES OF THE UNIVE...

1. A method of treating a subject for ischemia, comprising:(1) providing a patterned biomaterial comprising: at least one cord, formed by embedding cells in a naturally-derived or synthetic scaffolding with a pre-specified architecture and spatially organizing the cells within the scaffolding, wherein the at least one cord comprises endothelial cells; and
(2) implanting the patterned biomaterial into a tissue of the subject, wherein the patterned biomaterial is configured to promote the vascularization of the patterned biomaterial and the tissue of the subject, wherein the structure of the patterned biomaterial has a pre-specified architecture that acts as a template and spatial guidance for the subject's vasculature, such that the subject's vasculature invades and integrates at least partially within the at least one cord.

US Pat. No. 10,426,867

BIOCOMPATIBLE POLYCAPROLACTONE FUMARATE FORMULATIONS

Mayo Foundation for Medic...

1. A scaffold for tissue regeneration, the scaffold comprising:a blend of a polymer having the Formula (I)
H-A1-B-A2-C-A1-B-A2-H  (I)
wherein
A1 is

A2 is

B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene,
C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene;
C is

and geometric isomers thereof;
and n is an integer from 1 to 50, and
a polymer having the Formula (II)

wherein
D1 is

D2 is

D3 is

E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl,
C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl;
F is
and geometric isomers thereof;and n is an integer from 1 to 50;
wherein the polymer of Formula (I) comprises 20 wt. % to 80 wt % of the scaffold, and the polymer of Formula (II) comprises 20 wt. % to 80 wt % of the scaffold, and
wherein the polymer of Formula (I) is formed using a first initiator such that B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene, C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene, and
wherein the polymer of Formula (II) is formed using a second initiator such that E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl, C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl, and
wherein the first initiator is different from the second initiator.

US Pat. No. 10,426,864

STORAGE APPARATUS HAVING AIR PURIFYING MODULE

SEOUL VIOSYS CO., LTD., ...

1. An air purifying system including,a case having a top surface that is flat, a bottom surface opposite to the top surface, and a side surface connecting the top surface and the bottom surface;
an air inlet arranged on the bottom surface to introduce an air from an exterior of the case to an interior of the case;
a circulation fan arranged inside the case and disposed to receive the air from the air inlet and to generate an air flow moving in a first direction, wherein the top surface of the case is connected to the side surface though a rounded corner structured to cause at least a portion of the generated air flow to change an air flow direction to a second direction, the air moving in the second direction along the top surface,
a light emitting diode part arranged above the air inlet and including a light emitting diode positioned to sterilize the air flow moving in the second direction;
an air outlet positioned to discharge the air to the exterior of the case; and
a collection filter arranged in the case and configured to capture bacteria to increase a sterilization efficiency of the air purifying system,
wherein the first direction is toward the top surface and the second direction is substantially perpendicular to the first direction.

US Pat. No. 10,426,863

LIQUID SPRAY DEVICE WITH CONCEALED ELECTRIC CONDUCTIVE STRUCTURE

Vida International Inc., ...

1. A liquid spray device with a concealed electric conductive structure, which is used for atomizing and then spraying a liquid stored therein, comprising:a base;
a control means arranged on a front side of the base;
a liquid storage means separately arranged above or below the control means, and provided with a liquid sucking outlet;
a spray unit comprising a bracket and a vibrator arranged on the bracket, wherein the bracket is movably pivoted on the control means, and the vibrator abuts against the liquid sucking outlet of the liquid storage means via the movement of the bracket; and
a housing separately connected to the base to cover the control means and the spray unit, wherein a spray opening is provided at a location corresponding to the vibrator, and wherein a conductive pivoting structure is provided between the control means and the bracket, the bracket is provided with a wire recess, a wire is arranged within the wire recess, one end of the wire is electrically connected to the conductive pivoting structure, and the other end of the wire is electrically connected to the vibrator.

US Pat. No. 10,426,862

DIFFUSING APPARATUS AND METHODS

SPDI Holdings, Inc., Alp...

1. A diffusing apparatus for diffusing essential oils into the air, the apparatus comprising:a reservoir configured to hold essential oils in an internal cavity;
a controller assembly removably coupled to the reservoir, the controller assembly comprising an air inlet port, a first controller, and a micro air pump unit;
a base communicably connected to the controller assembly, the base comprising a second controller, wherein the second controller is communicably connected to the first controller; and
a tube in fluid connection at a first end with the micro air pump unit and extending into the reservoir, the tube providing a path for pressurized air from the micro air pump unit into the reservoir through a plurality of orifices at a second end of the tube.

US Pat. No. 10,426,860

AROMA DIFFUSER AND OIL SUPPLY METHOD

Shenzhen NearbyExpress Te...

1. An aroma diffuser, comprising:a main body, provided therein with a liquid storage chamber, the liquid storage chamber being configured to store a liquid; and
an oil storage tube configured to store an essential oil,
wherein when the aroma diffuser works, a bottom portion of the oil storage tube is in fluidic communication with the liquid storage chamber, allowing the essential oil in the oil storage tube to flow from the bottom portion of the oil storage tube into the liquid storage chamber as the liquid in the liquid storage chamber is being consumed.

US Pat. No. 10,426,859

DEVICE FOR RELEASING VOLATILE SUBSTANCES

ZOBELE ESPANA, S.A., Bar...

1. A device for releasing volatile substances comprising a container containing the volatile substances located in a fixed position and means for generating an air flow in order to release the volatile substances, wherein said means for generating an air flow comprise:a movable body, the movement of which generates the air flow, wherein said movable body is a sheet which swivels with respect to a shaft;
at least one magnet arranged on said movable body on an end opposite to the swivel end of said sheet; and
means for generating magnetic flux the actuation of which causes the displacement of said movable body by the repulsion force between said at least one magnet on the movable body and said magnetic flux.

US Pat. No. 10,426,858

DEVICE FOR RELEASING VOLATILE SUBSTANCES

Zobele Espana, S.A., Bar...

1. A device for releasing volatile substances comprising:a support (9) for positioning a receptacle (3) containing the volatile substances; and
means for generating a flow of air for releasing the volatile substances, wherein said means for generating a flow of air comprise:
a mobile body (1) joined to said support (9);
at least one magnet (2) disposed in said mobile body (1); and
means for generating a magnetic flux (4, 5) disposed close to the mobile body (1) in at least one position amongst one or more positions of said mobile body (1) and that comprise a detector (5) that drives the generation of magnetic flux upon detecting the magnet (2) or one of the magnets (2) of said mobile body (1), the operation of which causes the movement of said mobile body (1) by means of the repulsive force between said at least one magnet (2) in the mobile body (1) and the magnetic flux,
wherein said mobile body (1) is a rotary disc with respect to its center.

US Pat. No. 10,426,857

SYSTEMS, DEVICES, AND METHODS INCLUDING IMPLANTABLE DEVICES WITH ANTI-MICROBIAL PROPERTIES

Gearbox, LLC, Bellevue, ...

1. An insertable device, comprising:a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;
circuitry configured to detect one or more microorganisms present proximate at least one of the outer surface, the inner surface, or the one or more fluid-flow passageways; and
one or more actively controllable anti-microbial regions included on at least one of the outer surface or the inner surface, or embedded in the body structure, at least one of the one or more actively controllable anti-microbial regions having a wettability switchable feature configured to actuate between a first anti-microbial state and a second anti-microbial state responsive to detection of at least one microorganism by the circuitry.

US Pat. No. 10,426,856

DECONTAMINATION SYSTEM

AIREX CO., LTD., Nagoya-...

1. A decontamination system for decontaminating, with respect to one or more rooms targeted to be decontaminated, an inside of each room targeted to be decontaminated, by using decontamination gas, the decontamination system comprising compressed air-generating means for generating compression air; decontamination solution-supplying means for supplying decontamination solution;mixed gas-liquid adjusters to adjust, with respect to each room targeted to be decontaminated, decontamination mixed gas-liquid obtained by respectively mixing the compression air and the decontamination solution;
gas generators to gasify the mixed gas-liquid to generate decontamination gas;
air supplying pipes which communicate from the compressed air-generating means up to each of the mixed gas-liquid adjuster;
decontamination solution supplying pipes which communicate from the decontamination solution-supplying means up to each of the mixed gas-liquid adjuster; and
mixed gas-liquid supplying pipes which communicate from each mixed gas-liquid adjuster up to a corresponding gas generator of the gas generators,
characterized in that the compressed air-generating means, the decontamination solution-supplying means, and each respective mixed gas-liquid adjusters are arranged at positions which are spaced from each room targeted to be decontaminated, and each of the gas generators is arranged near or in each of the one or more rooms targeted to be decontaminated that corresponds thereto, and
a conveyance distance of each mixed gas-liquid supplying pipe with respect to each room targeted to be decontaminated is thereby longer than a conveyance distance of each of the decontamination solution supplying pipes that corresponds thereto.

US Pat. No. 10,426,855

SYSTEM AND METHOD FOR THE DECONTAMINATION OF INDOOR AIR AND SURFACES HAVING BIOLOGICAL, CHEMICAL OR PHYSICAL CONTAMINATION

1. A system for the decontamination of indoor air and surfaces having biological, chemical or physical contamination;a housing including a base unit and a cover hingedly secured thereto;
said base unit including:
(a) a back wall having an upper end, a lower end, a first side, a second side, a front side and a rear side;
(b) a first side wall extending forwardly from said first side of said back wall and having an upper end, a lower end, a front end, a rear end, an inner surface and an outer surface;
(c) a second side wall extending forwardly from said second side of said back wall and having an upper end, a lower end, a first end, a rear end, an inner surface and an outer surface;
(d) a top wall extending forwardly from said upper end of said back wall and having a back end, a front end, a first end, a second end, an inner surface and an outer surface;
(e) a bottom wall extending forwardly from said lower end of said back wall and having a back end, a front end, a first end, a second end, an inner surface and an outer surface;
(f) said first side wall of said base unit having an air inlet opening formed therein;
said cover including:
(a) a front wall having an upper end, a lower end, a first side, a second side, a front side and a rear side;
(b) said first side of said cover being hingedly secured to said second side wall of said base unit whereby said cover may be selectively hingedly moved with respect to said base unit between a closed position and an open position;
(c) said cover having first, second and third openings formed therein;
an ozone gas generator positioned in said base unit;
said ozone gas generator having an air inlet opening formed therein which is in communication with said air inlet opening of said base unit;
said ozone gas generator having an ozone gas discharge tube extending therefrom;
an electrical power cord extending from a source of electrical power into said base unit;
said power cord being electrically connected to said ozone gas generator to power the same;
an electrical timer positioned in said first opening of said cover;
an electrical switch positioned in said second opening of said cover;
an electrical operated exhaust fan assembly positioned in said third opening of said cover;
said exhaust fan assembly having a discharge side which is in communication with the area around said housing;
said exhaust fan assembly having an air intake side which is in communication with said base unit when said cover is in its said closed position whereby the ozone gas generated by said ozone gas generator will be exhausted from said housing through said discharge side of said exhaust fan assembly; and
said switch being electrically connected to said power cord, said ozone gas generator, said timer and said exhaust fan assembly so as to be able to control the operation of said ozone gas generator, said timer and said exhaust fan assembly.

US Pat. No. 10,426,854

APPARATUS AND METHOD TO MAKE HIGH LEVEL DISINFECTANT

Medivators Inc., Minneap...

1. An apparatus to make a peracetic acid high level disinfectant solution comprising:a) a solid dispensing system comprising a bulk dispenser for a solid mixture of TAED, a bulk dispenser for a solid mixture of sodium percarbonate, and a bulk dispenser for solid citric acid monohydrate,
b) a heated water delivery system,
c) a first reactor chamber to mix solid TAED and solid sodium percarbonate with heated water to provide a first peracetic acid solution,
d) a first conduit to deliver heated water from the heated water system to the first reactor chamber,
e) a second reactor chamber to mix the first peracetic acid solution with solid citric acid monohydrate to provide a pH controlled peracetic acid solution,
f) a second conduit to deliver the peracetic acid solution from the first reactor chamber to the second reactor chamber,
g) a storage reservoir to dilute the pH controlled peracetic acid solution with water to provide the peracetic acid high level disinfectant solution,
h) a third conduit to deliver the pH controlled peracetic acid from the second reactor chamber to the reservoir, and
i) a fourth conduit to deliver water to the storage reservoir.

US Pat. No. 10,426,853

APPARATUS TO CONTROL REACTION OF PEROXIDE AND ALKALINE

1. An apparatus for supplying a peroxide composition and an alkaline composition simultaneously for removal and destruction of microbiological and organic contamination on a surface comprising:a power module;
a means to activate the power module;
a pump connected to the power module;
a pump intake line, wherein one end of the pump intake line is connected to the pump and the other end is connected to at least one pump check valve system, wherein each pump check valve system further comprises:
a pump check valve, wherein the pump check valve is attached to the pump intake line and a check valve line,
a solenoid valve, wherein the solenoid valve is connected to the check valve line and composition input line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within a reservoir, and wherein the reservoir of at least one pump check valve system contains hydrogen peroxide;
a pump discharge line connected to the pump;
an injector connected to the pump discharge line;
an injector intake line, wherein the injector intake line is independent of the pump intake line and the at least one pump check valve system, and one end of the injector intake line is connected to the injector and the other end is connected to an injector valve system, wherein the injector valve system is independent of the pump intake line and the at least one pump check valve system, and the injector valve system further comprises:
a solenoid valve, wherein the solenoid valve is attached to the injector intake line and a composition intake line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within an injector reservoir that contains an alkaline composition;
a metering device, wherein the metering device is located at the intersection of the injector and the injector intake line;
an injector output line, wherein one end of the injector output line is connected to the injector and the other end is connected to a spray line;
a one way check valve, wherein the one way check valve is connected to the spray line and a handheld spray wand,
wherein the power module further comprises a means to activate the solenoid valves individually and a means to activate the pump.

US Pat. No. 10,426,852

ULTRAVIOLET-BASED DETECTION AND STERILIZATION

Sensor Electronics Techno...

1. A system comprising:a disinfection chamber comprising:
a plurality of ultraviolet sources configured to irradiate an object located within the disinfection chamber from a plurality of directions, wherein at least some of the plurality of ultraviolet sources emit UV-C electromagnetic radiation;
a set of visible light sources configured to irradiate the object with visible light from a set of directions; and
a set of cameras configured to acquire image data of the object from a plurality of directions; and
a computer system including a set of computing devices, wherein the computer system is configured to perform a sterilization procedure for the object, wherein the sterilization procedure includes operating the plurality of ultraviolet sources and the set of visible light sources using the image data to evaluate shadow data to ensure that the plurality of ultraviolet sources deliver a dose of ultraviolet radiation onto each exterior surface of the object sufficient to result in at least a log reduction of a target contaminant.

US Pat. No. 10,426,851

PROTECTIVE STERILIZATION SYSTEM

1. A protective sterilization system comprising:a protective container, having:
a first casing member having a body forming a storage space having:
the body extending from a first enclosed end to a first open end, the first enclosed end having at least a first side, a second side, and a third side, the third side being opposite the first open end and extending between the first side and the second side;
a bottom surface; and
a first protection device positioned within the storage space at the first enclosed end of the body and attached to at least the first side, the second side, and the third side of the first enclosed end and extending inwardly into the storage space from at least the first side, the second side, and the third side of the first enclosed end;
a plurality of support arms rigidly attached to the bottom surface of the storage space and configured to suspend an implement within the storage space of the container; and
a second casing member having a second enclosed end and a second open end and configured to removably attach to the first casing member at the first open end of the first casing and the second open end of the second casing member via tongue and grooves, the second casing member having:
a second protection device extending from the second enclosed end configured to hold the implement in a stationary position;
wherein the container when closed is sterilized to clean the implement.

US Pat. No. 10,426,850

COLLAGEN MIMETIC PEPTIDES FOR TARGETING COLLAGEN STRANDS FOR IN VITRO AND IN VIVO IMAGING AND THERAPEUTIC USE

THE JOHNS HOPKINS UNIVERS...

1. A collagen mimetic peptide (CMP) having the formula:L-S-[Gly-X-Y]n-Gly-X-Y-[Gly-X-Y]n; wherein
L is IRDye-800CW or IRDye 680RD;
S is aminohexanoic acid;
X is proline;
Y is hydroxyproline;
Gly is glycine; and
n is 4.

US Pat. No. 10,426,843

DELTA-OPIOID RECEPTOR TARGETED AGENT FOR MOLECULAR IMAGING AND IMMUNOTHERAPY OF CANCER

1. A compound having Formula I,
wherein
n is an integer of from 1 to 50;
L1 and L2 are optional linking moieties of from 1 to 100 atoms in length; and
Ab is an antibody;
Tg* is H, a protecting group, or a detectable moiety; and
Dmt-Tic is represented by

where R1 and R2 are independently selected from H and CH3.

US Pat. No. 10,426,842

TARGETED NANOPARTICLE CONJUGATE AND METHOD FOR CO-DELIVERY OF SIRNA AND DRUG

The Curators of the Unive...

1. A nanoparticle conjugate comprising a small interfering RNA (siRNA) covalently linked to an antibody that is bonded to the surface of a gelatin nanoparticle that physically encapsulates a drug, wherein one end of siRNA is coupled to an epidermal growth factor receptor (EGFR) targeting monoclonal antibody via a thio-ether bond, and a lysine functional group present on the antibody is bridged with carboxyl groups present on the gelatin nanoparticle.

US Pat. No. 10,426,838

COMPOSITE PARTICLES INCLUDING CELLULOSE, INORGANIC COMPOUND, AND HYDROXYPROPYL CELLULOSE

ASAHI KASEI KABUSHIKI KAI...

1. A composite particle comprising from 50 to 80 parts by mass of cellulose, from 10 to 40 parts by mass of an inorganic compound and from 4 to 11 parts by mass of hydroxypropyl cellulose based on 100 parts by mass of a total of contents of the cellulose, the inorganic compound, and the hydroxypropyl cellulose.

US Pat. No. 10,426,837

COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

Sage Therapeutics, Inc., ...

1. A compound of Formula (I-c):
wherein:
n is 0, 1, 2, 3, 4, or 5;
Ring A is aryl or heteroaryl;
R3A is C1-6 alkyl;
R1 is hydrogen, C1-3alkyl, C2-6 alkenyl, or C3-6 carbocyclyl;
R2 is absent or hydrogen;
Ra is halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, —S(O)2RD, or —ORY, wherein RY is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, or —S(O)2RD;
RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
each of RB and Rc is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a ring; and
RD is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl.

US Pat. No. 10,426,835

METHOD FOR TREATING PEYRONIE'S DISEASE

BMR Medical LLC, Mariett...

1. A method of treating a patient having a plaque mass associated with Peyronie's disease in a penile region, comprising the steps of:(a) performing a battery of tests to quantify an initial state of parameters associated with Peyronie's disease in the patient;
(b) applying shock wave treatment to the plaque mass in the penile region, thereby softening the plaque mass and disrupting any calcification in the plaque mass wherein the shock wave treatment comprises a low intensity shock wave treatment having a minimum energy of 0.10 mJmm2;
(c) applying carboxy treatment comprising injecting carbon dioxide into the plaque mass after the step of applying the shock wave treatment;
(d) repeating the battery of tests to quantify a current state of parameters associated with Peyronie's disease in the patient and comparing the current state to the initial state; and
(e) until the current state differs from the initial state by at least a predetermined amount, repeating steps (b) through (d).

US Pat. No. 10,426,831

ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY

Beth Israel Deaconess Med...

1. A nucleic acid molecule encoding a polypeptide comprising a sequence at least 99% identical to SEQ ID NO:3.

US Pat. No. 10,426,830

ALTERING THE IMMUNDOMINANCE HIERARCHY USING A DNA VACCINE EXPRESSING CONSERVED REGIONS

THE UNITED STATES OF AMER...

1. A method of inducing an immune response to an HIV protein, the method comprising administering:a first nucleic acid encoding a first conserved element polypeptide, wherein the conserved elements are from the HIV protein and the polypeptide comprises at least six conserved elements, each less than 50 amino acids in length, where the conserved elements are joined by linkers;
a second nucleic acid encoding a second conserved element polypeptide that comprises a variant of each of the at least six conserved elements contained in the first conserved element polypeptide, wherein each variant in the second conserved element polypeptide differs from the corresponding conserved element in the first conserved element polypeptide by at least 1, 2, or 3 amino acids; and
after administration of the first and the second nucleic acids, administering a nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, wherein the nucleic acid encoding the full-length HIV protein or substantially full-length HIV protein is administered at least two weeks after the first and second nucleic acids encoding the conserved element polypeptides; and further, wherein the nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, is administered as a plasmid that comprises an expression cassette comprising a nucleic acid sequence encoding the full-length HIV protein, or substantially full-length HIV protein, operably linked to a promoter.

US Pat. No. 10,426,785

C-19 STEROIDS FOR INHIBITING NEOVASCULARIZATION

Curadis GmbH, Erlangen (...

1. A method of treating or preventing a pathological condition involving angiogenesis in a patient, the method comprising:administering an effective amount of a compound to the patient, wherein the compound is defined by Formula 1:

wherein:
a, b and c respectively denote, independently from each other, a single bond or a double bond, with the proviso that at least one of a, b and c represents a double bond, and with the proviso that if a is single bond and b is double bond, R2 is not H;
R1 is either hydrogen or C1 to C6 alkyl;
R2 is either OR5 or hydrogen, wherein R5 is hydrogen or C1 to C12 straight chain or branched alkyl;
R3 is, in case of c being a single bond, either hydrogen or C1 to C6 alkyl, or in case of c being a double bond, CHR5, wherein R5 is the same as defined before; and
R4 is hydrogen, C1 to C12 alkyl, phenyl unsubstituted or substituted by C1 to C12 alkyl or COR6 acyl group; R6 being hydrogen, C1 to C12 straight chain or branched alkyl, phenyl or benzoyl, respectively unsubstituted or substituted by C1 to C12 alkyl, or any group leading to hydroxyl upon biological metabolization or chemical deprotection, the group being an ester, ether, acetale, carbonate, ca late, phosphate, phosphonate, ketal, sulfate, or sulfonate; and salts thereof.

US Pat. No. 10,426,784

IMIDAZODIAZEPINE COMPOUND

Astellas Pharma Inc., Ch...

14. A pharmaceutical composition, comprising a compound or a salt thereof according to claim 1 and a pharmaceutically acceptable excipient.

US Pat. No. 10,426,780

ANTIVIRAL THERAPY

ViiV Healthcare Company, ...

1. A combination comprising a compound of formula (I)or a pharmaceutically acceptable salt thereof, and rilpivirine, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,426,771

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-COMPOUNDS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAY DISEASES

Sulfateq B.V., Groningen...

1. A method of treating a chronic obstructive airway disease in a subject, the method comprising administering to the subject a compound according to formula (I) or a pharmaceutically acceptable salt thereof,
wherein R1 and R2 are the same or different, and represent a C1-C4 linear or branched alkylgroup;
wherein R3 represents hydrogen;
n is 1;R4 is CO—N—R5; wherein R5 comprises linear or branched alkyl group comprising 1-12 carbon atoms or cyclic alkyl group, substituted with nitrogen or oxygen; and wherein nitrogen is amine, quaternary amine, guanidine or imine, and oxygen is hydroxyl, carbonyl or carboxylic acid, and wherein oxygen and nitrogen together form amide, urea or carbamate groups;wherein the compound is in a formulation suitable for inhalation.

US Pat. No. 10,426,769

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING OBESITY OR LIVER DISEASES, CONTAING TLR7 AGONIST

KNOTUS CO., LTD., Guri-s...

1. A method of inhibiting liver fat accumulation in mammals in need thereof, comprising administering by intraperitoneal injection to the mammals an effective amount of imiquimod having the following structure as a TLR7 agonist to inhibit liver fat accumulation:

US Pat. No. 10,426,768

SUBCUTANEOUS DELIVERY OF POLYMER CONJUGATES OF THERAPEUTIC AGENTS

Sarina Therapeutics, Inc....

1. A method for treating a disease or condition selected from the group consisting of restless leg syndrome and Parkinson's disease in a subject in need thereof, the method comprising the step of administering to the subject a poly(oxazoline) polymer conjugate comprising a water soluble poly(oxazoline) polymer and an agent, wherein a release profile of the agent is selectable based on the selection of the poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure:
wherein
L is

R3 forms a linkage with the poly(oxazoline) polymer;
R4 is —CH2—C(O)—O—, —CH(CH3)—C(O)—O—, —CH2—CH2—C(O)—O—, —CH2—CH2—CH2—C(O)—O—, —CH2—O—C(O)—, —CH(CH3)—O—C(O)—, —CH2—CH2—O—C(O)— or —CH2—CH2—CH2—O—C(O)—;
R is an initiating group;
R1 is a non-reactive group;
A is rotigotine, pramipexole, quinagolide, fenoldopam, apomorphine, 5-OH-DPAT, ropinirole, pergolide, cabergoline, bromocriptine, theophylline, istradefylline, preladenant trihexyphenidyl, biperidin, hyoscyamine, selegiline, rasagiline, tolcapone or entacapone;
a is ran which indicates a random copolymer or block which indicates a block copolymer;
o is from 1-50;
m is from 1-1000; and
T is a terminating group,
wherein the release profile is dependent on the selection of R4.

US Pat. No. 10,426,762

INHIBITORS OF HEPATITIS C VIRUS POLYMERASE

COCRYSTAL PHARMA, INC., ...

1. A compound according to Formula I:
or a pharmaceutically acceptable salt thereof,
wherein:
X is —CH2— and Y is —NR1—;
R1 is —C5-6hydroxyalkyl, —S(O)2—C0-4alkyl-RO, —C0-4alkyl-RO, —C0-3alkyl-C(O)—C0-4alkyl-RO, —C0-3alkyl-C(O)O—C0-4alkyl-RO;
wherein:
RM and RN are independently hydrogen, —C1-4alkyl, or RM and RN together with the atoms to which they are attached can form a 4- to 6-membered ring; and
RO is (a) a 5- to 7-membered cycloalkyl, substituted with a —C1-3alkyl, aryl, —O-aryl, or —NRMRN moiety, (b) a 7-membered cycloalkyl optionally substituted with a hydroxyl, or (c) a 6- to 10-membered aryl, monocyclic or bicyclic, and substituted with one to three moieties independently selected from —C1-4alkyl, halogen, —NRMRN, —C1-4haloalkyl, —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, —O-aryl, and aryl, provided that at least one such substitution is —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, or —O-aryl;
R2 is —C1-5alkyl optionally substituted with 1-5 halogens, —C1-5alkoxy, —C5-7cycloalkyl-C0-3alkyl in which the alkyl is optionally substituted with 1-3 halogens, —C1-4alkyl-C3-5cycloalkyl, or phenyl optionally substituted with 1 or 2 halogens or —C1-3alkyl groups optionally substituted with 1-3 halogens;
R3 is —RA—RB;
wherein RA is a phenyl moiety optionally substituted with one or two Z, in which each Z is independently halogen, —C1-3alkyl, —C1-3haloalkyl, —C1-3alkoxy, or cyano; and
wherein RB is —N(RU)C(O)—RQ;
wherein RQ is a thiazolyl, optionally substituted with one or two RZ, in which each RZ is independently —C1-3alkyl, —C1-3alkoxy, or —NRMRN;
RS and RT are each independently hydrogen or —C1-4alkyl, or one of RS and RT is hydrogen and the other is —C(O)-5- to 9-membered aryl; and
RU is hydrogen or —C1-4alkyl;
provided that, when RA is phenyl, then RB appears at the para or meta position relative to the thiophene moiety; and
R4 is hydrogen, —C1-4alkyl, —C1-4alkyl-OC(O)O—C1-4alkyl, —C1-4alkyl-OC(O)—C1-4alkyl, —C1-4alkyl-OC(O)O—C3-6cycloalkyl, 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl-, —C0-3alkyl-C5-6aryl, or —C1-4alkyl-NRVRW; and
RV and RW are independently hydrogen or —C1-4alkyl.

US Pat. No. 10,426,760

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject with melanoma, thyroid cancer, or colorectal cancer, said method comprising administering to the subject:an effective amount of a compound of formula (Ia):

or a pharmaceutically acceptable salt thereof,
wherein:
L1 is a bond or —N(H)C(O)—;
each R1 is —N(R5)—C(X)—R7, lower alkyl, or optionally substituted heteroaryl;
R2 is hydrogen or halogen;
R4 is hydrogen;
R3 is optionally substituted lower alkyl or optionally substituted aryl;
m is 0, 1, 2, or 3;
Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen;
R5 is hydrogen;
X is O; and
R7 is lower alkyl.

US Pat. No. 10,426,758

SIBIRILINE DERIVATIVES FOR USE FOR PREVENTING AND/OR TREATING DISORDERS ASSOCIATED WITH CELLULAR NECROPTOSIS

Institut National de la S...

1. A method for inhibiting cellular necroptosis comprising the administration to a patient in need thereof of an effective amount of a compound of the following general formula (I)
or a pharmaceutically acceptable salt and/or solvate thereof,
wherein:
R1 is H, a (C1-C6)alkyl or a (C3-C6)cycloalkyl, or R1 forms together with R2 or R4 a heterocycloalkyl;
R2 and R3 are H;
R4 to R6 are, independently of one another, H or OR10;
R10 is H or (C1-C6)alkyl;
R7 is H or halo;
R8 to R9 are, independently of one another, H; halo; or a group selected from (C1-C6)alkyl, heterocycle, aryl, heteroaryl, —(C1-C6)alkyl-aryl, and —(C1-C6)alkyl-heterocycle, said group being optionally substituted with one or more groups selected from halo, —OR36, —NR37R38, —SR39, —S(O)R40, —SO2R41, —SO2NR42R43, —OCOR44, —NR45COR46, —NR47C(O)OR48, —CO2R49, —CONR50R51, —OCONR53R54, —COR55, nitro (—NO2), cyano (—CN), oxo (?O), and a group selected from aryl, heterocycle and —(C1-C6)alkyl-heterocycle, said group being optionally substituted with one or more (C1-C6)-alkyl; and
R36 to R55 are, independently of one another, H, halo, benzoylbenzyl, or a group selected from (C1-C6)alkyl, aryl, heteroaryl, heterocycle, —(C1-C6)alkyl-heterocycle, and —(C1-C6)alkyl-aryl, said group being optionally substituted with one or more groups selected from halo, CF3 and (C1-C6)alkyl; or R37-R38, R42-R43, R50-R51, and/or R53-R54 may together respectively form a heterocycloalkyl.

US Pat. No. 10,426,753

SUPRAMOLECULAR COMBINATORIAL THERAPEUTICS

INVICTUS ONCOLOGY PVT. LT...

14. A supramolecular combinatorial therapeutic (SCT) comprising a taxane-lipid conjugate, wherein the taxane-lipid conjugate is a paclitaxel-lipid conjugate or a docetaxel-lipid conjugate; andwherein the paclitaxel-lipid conjugate is selected from the group consisting of conjugate 16 and conjugate 17


wherein the docetaxel-lipid conjugate is selected from the group consisting of conjugates 18-20 and conjugate 33

US Pat. No. 10,426,752

MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS

Colgate-Palmolive Company...

1. A method for providing one or more oral care beneficial effects, selected from anti-inflammation and anti-bone loss effects, to a subject in need thereof, comprising administering to the oral cavity of the subject an amount from 0.05 wt. % to 5 wt. % of at least one menthol-derivative compound conforming to Formula 1 to a subject:
wherein
X is an oxygen atom or an NH radical; and
R is an unsubstituted or substituted aryl radical, andin combination with a water-swellable synthetic, anionic, linear copolymeric polycarboxylate.

US Pat. No. 10,426,751

ALLOSTERIC ACTIVATORS FOR TREATMENT OF PHENYLKETONURIA

McMaster University, Ham...

1. A method of restoring phenylalanine hydroxylase activity in mammalian phenylalanine hydroxylase comprising exposing said phenylalanine hydroxylase to shikimic acid, a pharmaceutically acceptable salt of shikimic acid, a functionally equivalent analogue thereof selected from the group of:i) an analogue of shikimic acid having one or more additional substituents on the cyclohexene ring of shikimic acid, wherein the additional substituent is selected from the group consisting of hydroxyl, thio, —OR1, —NH2, NO2, —NHR1, —NR1R2, —SR1 and a C1-C6 alkyl group, C1-C6 alkoxy, and C1-C6 alkanol, wherein R1 and R2 are independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkanol and C1-C6 alkoxy;
ii) an analogue in which one or more of the hydroxyl groups on the cyclohexene ring of shikimic acid is substituted with hydrogen, thio, C1-C6 alkyl, C1-C6 alkanol, C1-C6 alkoxy, —OR1, —NH2, NO2, —NHR1, —NR1R2, or —SR1; and
iii) an analogue in which the cyclohexene ring of shikimic acid is replaced with a cyclohexane ring;or combinations thereof.

US Pat. No. 10,426,745

POLYMERIC METFORMIN AND ITS USE AS A THERAPEUTIC AGENT AND AS A DELIVERY VEHICLE

THE UNIVERSITY OF NORTH C...

1. A nanoparticle comprising:i. a lipid outer membrane; and
ii. a polymer encapsulated by the lipid outer membrane, said polymer having the following chemical formula I

wherein, p is 1 or 2, n is an integer from two (2) to 10,000;
and
wherein, X is hydrogen or a residue of Metformin having the formula:

wherein at least 5% of X in the polymer is a residue of Metformin.

US Pat. No. 10,426,742

FORMULATION AND PROCESS FOR MODULATING WOUND HEALING

BioMendics, LLC, Fairlaw...

1. A method for promoting wound healing in a patient having a wound or skin condition, comprising administering to a patient a therapeutically effective amount of a formulation comprising:a first autophagy modulating compound having the structure (I):

wherein L is a linker comprising —C?C—;
R1 and R2 are independently substituents at any available position of the phenyl rings;
m and n are, independently, 0, 1, 2, or 3 representing the number of substituents on the rings, respectively, and at least one of m or n must be ?1;
wherein each R1 and R2 is independently selected from:
—R5, wherein R5 is selected from (C1-C6)alkyl, (C2-C6)alkenyl, or (C2-C6)alkynyl; optionally substituted with 1 to 3 substituents selected from —OH, —SH, -halo, —NH2, or NO2;
—YR6, wherein Y is O, S, or NH; and R6 is selected from H or R5;
—ZR5, wherein Z is —N(C?O)— or —O(C?O)—;
-halo;
—NO2;
—SO3Na;
-azide; and
-glycosides
-and salts thereof;
with the proviso that the first autophagy modulating compound is not resveratrol or 4,4?-(ethyne-1,2-diyl)diphenol (TOLECINE, also known as 4,4?-dihydroxytolan).

US Pat. No. 10,426,739

ADHESIVE PATCH ASSEMBLY WITH OVERLAY LINER AND SYSTEM AND METHOD FOR MAKING SAME

3M Innovative Properties ...

15. A method of making an article comprising an adhesive patch assembly, the method comprising the steps of:providing a patch having a periphery, the patch including a backing, a skin-contact adhesive coupled to the backing, a drug, and a skin penetration enhancer;
providing a release liner including a first major surface and a second major surface opposite the first major surface, at least the first major surface configured to present release characteristics relative to the skin-contact adhesive of the patch, the release liner having a first portion and a second portion, wherein each of the first portion and the second portion are dimensioned to accommodate the patch, and wherein the release characteristics of the first major surface of the first portion of the release liner are coextensive with the first major surface of the second portion of the release liner;
including a slit into the second portion of the release liner, wherein the second portion further comprises two separate sections separated by the slit;
positioning the patch on the release liner, such that patch is located on the second portion of the release liner and the first portion of the release liner is free of the patch, wherein when the patch is located between the first portion and the second portion of the release liner the first and second portions having said release characteristics extend a distance beyond the periphery of the patch;
folding the release liner about a hinge located between the first portion and the second portion to locate the patch between the first portion and the second portion of the release liner and to form an adhesive patch assembly; and
packaging the adhesive patch assembly in a separate and distinct hermetically-sealed pouch.

US Pat. No. 10,426,737

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

Novartis AG, Basel (CH)

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
n is 0, 1, 2, 3 or 4;
p is 0, 1, 2, 3, 4, 5, 6, 7 or 8;
L1 is —O— or a bond;
L2 is —OC(O)— or —C(O)O—;
R1 is

v is 0, 1, 2, 3 or 4;
w is 0, 1, 2 or 3;
R and R? are each, independently, hydrogen or C1-8 alkyl;
R2 is selected from: (i) C6-20 alkyl optionally substituted with a hydroxyl, and (ii) C15-19 alkenyl;
R3 is selected from: C4-22 alkyl, C12-22 alkenyl,

US Pat. No. 10,426,735

MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS

Massachusetts Institute o...

1. A multiply modified alginate polymer having a structure according to Formula IIIwhereinX is oxygen, sulfur, or NR4;
R1, R6, R7, R8, and R9 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group; wherein R1 and R6 are not hydrogen;whereinY1 and Y2 independently are hydrogen or —PO(OR5)2; or
Y2 is absent, and Y1, together with the two oxygen atoms to which Y1 and Y2 are attached form a cyclic structure as shown in Formula IV
whereinR2 and R3 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group; or
R2 and R3, together with the carbon atom to which they are attached, form a 3- to 8-membered unsubstituted or substituted carbocyclic or heterocyclic ring; and
R4 and R5 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group.

US Pat. No. 10,426,732

RAPIDLY DISINTEGRATING TABLET, AND METHOD FOR PRODUCING SAME

DAICEL CORPORATION, Osak...

1. An orally disintegrating tablet having a specific surface area of from 1.60 to 2.50 mm2/mg, a weight of from 10 to 30 mg, and a diameter of 4 mm or less, which comprises a disintegrative particulate composition containing crystalline cellulose in an amount of 1% to 40% by weight of a total weight of the composition, and has a disintegration time in water of 7 seconds or less and an oral disintegration time of 5 seconds or less.

US Pat. No. 10,426,730

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A microsphere comprising:a first biodegradable polymer encapsulating at least one additional microsphere, the at least one additional microsphere including a second biodegradable polymer and at least one bioactive agent, wherein the first biodegradable polymer and the second biodegradable polymer are different and one of the first biodegradable polymer or the second biodegradable polymer is oxidized cellulose.

US Pat. No. 10,426,727

FLUOROPOLYMER EMULSIONS WITH BRANCHED SEMIFLUORINATED BLOCK COPOLYMER OR PHOSPHOLIPID SURFACTANT FOR THE DELIVERY OF HYDROPHOBIC DRUGS

Wisconsin Alumni Research...

2. An emulsion for delivery of a therapeutic agent, said emulsion comprising:an aqueous solution;
semi-fluorinated block copolymers; wherein each of said semi-fluorinated block copolymers independently comprises a hydrophilic block, a hydrophobic block and a fluorophilic block; wherein each of said semi-fluorinated block copolymers has a branched structure wherein said hydrophilic block comprises a first branch, said hydrophobic block comprises a second branch and said fluorophilic block comprises a third branch; and
said therapeutic agent comprising a hydrophobic compound;
said emulsion comprising a continuous phase and a dispersed phase, wherein said continuous phase comprises said aqueous solution and said dispersed phase comprises said semi-fluorinated block copolymers and said therapeutic agent;
wherein each of said semi-fluorinated block copolymers independently has the formula (FX9A) or (FX9B):

wherein q is an integer selected from the range of 10 to 300, o is an integer selected from the range of 5 to 20, and p is an integer selected from the range of 3 to 15.

US Pat. No. 10,426,721

HIGH-GLOSS PHOTOCROSSLINKABLE COSMETIC COMPOSITION

1. A photocrosslinkable cosmetic composition, comprising in a physiologically acceptable medium:from 20% to 40% of at least one photocrosslinkable urethane dimethacrylate compound P1 according to formula (II):

wherein:
i is an integer ranging from 1 to 6,
j is an integer ranging from 1 to 6, and
R?1, R?2, R?3, and R?4, identical or different, represent a hydrogen atom or a C1-C10 alkyl chain,
from 40% to 65% of at least one photocrosslinkable urethane dimethacrylate compound P2 according to formula (IV):

wherein:
i is an integer ranging from 1 to 6,
j is an integer ranging from 1 to 6,
k is an integer ranging from 2 to 100,
l is an integer ranging from 1 to 10,
R1, R3, R3 and R4, identical or different, represent a hydrogen atom or a C1-C10 alkyl chain,
-A?- represents a linear or branched C1-C20 divalent alkylene group, or a C5-C20 divalent cycloalkylene radical,
from 0% to 10% of an acrylate copolymer film-forming polymer P3, and
from 1% to 10% of an ?-hydroxyketone photoinitiator, an acylphosphine oxide photoinitiator, or mixtures thereof,
wherein the percentages are expressed in relation to the total weight of said composition.

US Pat. No. 10,426,718

COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS AND DELAYING AGING OF SKIN

Phyto Tech Corp., Rancho...

1. A method for treating hair loss or inducing hair growth in an individual who has telogen effluvium (TE) or alopecia areata comprising applying an effective amount of a dihydromyricetin compound to scalp of an individual, wherein the dihydromyricetin compound is of formula (I):
wherein each X is independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, halo, alkoxyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl;
wherein said dihydromyricetin compound is synthetic or is purified from a whole plant or a plant tissue of Hovenia dulcis; and
wherein X is independently selected from the group consisting of —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CH2CH(CH3)2, —C(CH3)3, —CH2CH2CH2CH2CH3, —CH2C(CH3)2CH3, —C(CH3)2CH2CH3, —CH2CH2CH(CH3)2, —CH2CH2CH2CH2CH2CH3, —CH2C(CH3)2CH2CH3, —CH2CH2C(CH3)2CH3, —CH2CH2CH2CH(CH3)2, —CH2CH(CH2CH3)CH2CH3, —CH2CH2OCH3, —CH2CH2CH2OCH3, —CH2CH2CH2OCH2CH3, and —CH2CH2CH2CH2OCH2CH3.

US Pat. No. 10,426,717

GLYCOL ESTERS OF DICAFFEOYLQUINIC ACID AND USES THEREOF

PLANT ADVANCED TECHNOLOGI...

1. A compound of general formula (I)
wherein
R1 represents a radical chosen from the group consisting of the radicals of the following formulae (IIa) to (IIe), (III), (IVa) to (IVb) and (Va) to (Vd):

and wherein any two of the radicals R2, R3, R4 and R5 represent a caffeoyl group, the other two representing a hydrogen atom.

US Pat. No. 10,426,713

METHOD OF TREATING HAIR OR SKIN WITH A PERSONAL CARE COMPOSITION IN A FOAM FORM

The Procter and Gamble Co...

1. A method of treating hair or skin with a creamy foam, the method comprising:a. dispensing a personal care composition from a mechanical foam dispenser as a dosage of foam; wherein the dispenser does not contain a propellant or is substantially free of a propellant;
b. applying the dosage of foam to hair or skin;
c. rinsing the dosage of foam from hair or skin;
wherein the personal care composition comprises:
a viscosity of less than 60 cP;
a lather volume greater than 77 cm3;
from about 50% to about 90%, by weight of the composition, water;
from about 10% to about 50%, by weight of the composition, a surfactant system wherein the surfactant system comprises:
(i) from about 10% to about 30%, by weight of the composition, of an acyl glutamate;
(ii) from about 0.5% to about 7%, by weight of the composition, of a zwitterionic co-surfactant;
wherein the surfactant system is substantially free of sulfate-based surfactants.

US Pat. No. 10,426,711

DENTAL IMPLANT FRAMEWORK

1. A dental prosthesis and a plurality of implants and abutments to which the dental prosthesis mates, wherein the dental prosthesis comprises:a plurality of support posts, a plurality of crowns and a dental implant framework;
where the position of the plurality of support posts and the plurality of crowns is determined from digital data defining the appropriate tooth position for the dental prosthesis;
where the plurality of support posts and the plurality of crowns consist of predefined dimensions;
a plurality of fittings to mate with the corresponding plurality of implants and abutments when inserted in the patient's mouth;
where the position of the plurality of fittings has been determined through the use of digital data identifying the location of the plurality of implants and abutments in the patient's mouth;
a bridging structure or plurality of bridging structures attaching the support posts and fittings to one another; and
the combination of the bridging structure or plurality of bridging structures, plurality of support posts, and plurality of fittings providing the complete embodiment of the dental implant framework.

US Pat. No. 10,426,710

SYSTEM, METHOD AND APPARATUS FOR TEETHING DEVICE

Teetherpop, LLC, Austin,...

1. A teething device, comprising:a base having a handle on an end and a coupling on an opposite end, a y-axis extending through both the handle and the coupling, an x-axis and a z-axis extending perpendicular to the y-axis and to each other, and the base and coupling being formed from a first material having a first hardness;
a reservoir configured to contain a liquid therein, the reservoir having a coupling sealed to the base coupling and configured to provide a watertight seal, the reservoir has apertures that are the only apertures formed therein, the apertures consist of slits that are repeatably self-sealing, all of the slits are located only along a terminal distal end of the reservoir, each slit has a default position wherein each slit is configured to be resiliently biased to automatically return to be substantially closed to essentially prevent the liquid from flowing therethrough, and a flexed position wherein each slit is configured to be opened by squeezing to allow the liquid to flow therethrough;
the base further comprises a protrusion that extends into the reservoir, and the protrusion is spaced apart and free of contact with the reservoir;
the reservoir is formed from a second material having a second hardness that is softer than the first hardness, such that the reservoir is configured to be used as a teething device and capable of being frozen; and
the reservoir comprises a shape that is parabolic in a first plane of reference defined by the x-axis and the y-axis, and the reservoir has a second shape that is elongated and generally elliptical in a second plane of reference defined by the x-axis and the z-axis, such that an entirety of the reservoir is generally human tongue-shaped.

US Pat. No. 10,426,709

FEEDING SET AND ENTERAL FEEDING PUMP

KPR U.S., LLC, Mansfield...

1. A feeding set for use with a feeding pump to deliver nutritional liquid to a patient, the feeding set comprising:a container to store the nutritional liquid;
tubing in fluid communication with the container and being adapted for mounting on the feeding pump, the tubing providing a fluid pathway for delivering the nutritional liquid from the container to the patient; and
an identification member representative of the nutritional liquid in the container, the identification member configured to permit identification by the feeding pump of at least one characteristic of the nutritional liquid upon mounting of the identification member on the feeding pump, the at least one characteristic of the nutritional liquid comprising at least one of a nutritional content, a fluid flow property, and a brand or brand name of the nutritional liquid.

US Pat. No. 10,426,708

DEVICES AND METHODS FOR PERCUTANEOUS ENDOSCOPIC GASTRONOMY AND OTHER OSTOMY PROCEDURES

Fidmi Medical Ltd., Caes...

1. A PEG feeding device for conducting fluid through a stoma to a stomach comprising:a tube sized to bridge a channel between the stomach and an outer abdominal surface;
an internal bolster, sized to resist movement out of the stomach through the stoma and connected to said tube;
an external bolster, sized to resist movement into the stoma and connected to said tube;wherein said external bolster includes at least one elastically deflectable elastic element including an underside which extends from said tube in a radial direction and contacting said outer abdominal surface at a contacting point located at a distance from an external opening of said stoma and wherein said at least one elastically deflectable elastic element defines a void under said at least one elastically deflectable elastic element and between said external opening of said stoma and said contacting point with said outer abdominal surface.

US Pat. No. 10,426,707

TAMPER-PROOF PILL DISPENSING SYSTEM AND METHODS OF USE

1. A method for administering a pill dispensing system for managing the distribution of pills to a patient, the method comprising the steps of:implementing an at least one tamper-proof pill storage container that provides an at least one pill magazine positioned within a housing of the pill storage container and configured for storing and selectively dispensing a plurality of pills through a pill outlet provided by the housing;
implementing a patient application residing in memory on an at least one patient device under the control of the patient, the patient application in selective communication with the at least one pill storage container;
implementing an at least one monitoring device in selective communication with the patient application, the at least one monitoring device configured for assisting the patient application with monitoring an at least one vital of the patient;
obtaining from the patient at least one of a security code, via the patient application, and an at least one biometric marker associated with the patient, via an at least one biometric sensor;
registering, via the patient application, a prescription associated with the pills contained within the at least one pill magazine of the at least one pill storage container, said prescription including a dosage interval and a dosage quantity;
upon the patient application determining that a dosage of the pills is available for the patient, based on the associated dosage interval:
notifying the patient via at least one of an audible alert, a visual alert and a vibrational alert via the at least one patient device;
obtaining from the patient at least one of the security code and the at least one biometric marker;
upon the patient application authenticating at least one of the security code and the at least one biometric marker:
transmitting a signal, via the patient application, to the at least one pill storage container, instructing said pill storage container to distribute a quantity of pills equal to the associated dosage quantity; and
upon said pill storage container distributing the pills to the patient:
transmitting a signal, via said pill storage container, back to the patient application; and
scheduling, via the patient application, a future dosage of the pills based on the associated dosage interval; and
upon the patient application determining that the at least one monitored vital is abnormal:
notifying the patient via at least one of an audible alert, a visual alert and a vibrational alert via the at least one patient device;
upon the patient application failing to receive a response from the patient within a pre-defined period of time, automatically alerting, via the patient application, local emergency personnel; and
temporarily suspending future dosages of the pills until the patient application determines that said monitored vital has returned to normal.

US Pat. No. 10,426,705

COLOSTRUM COLLECTION SYSTEM

LANSINOH LABORATORIES, IN...

1. An adapter system for facilitating collection of colostrum from a breast, the adapter system comprising:an adapter, comprising:
a body having a funnel connecting end for connecting to a breast shield of a breast pump system and a breast pump connecting end for connecting to a breast pump connector of the breast pump system;
a side port comprising a dispensing end, disposed between the funnel connecting end and the breast pump connecting end, configured for allowing the colostrum to pass out of the adapter;
a block inside the body, between the breast pump connecting end and the dispensing end, for directing the colostrum through the dispensing end, wherein the block comprises a flat wall oriented perpendicular to a cylindrical wall that forms the body of the adapter; and
an aperture in the block to allow suction force applied at the breast pump connecting end to generate suction at the funnel connecting end;
a removable reservoir comprising a wide end for removably attaching to the dispensing end of the adapter and a narrow end for attaching to a colostrum delivery device; and
a hand-expression funnel comprising a wide end for receiving colostrum and a narrow end for attaching to the colostrum delivery device.

US Pat. No. 10,426,704

PRE-DOSED APPLICATORS AND PACKAGING THEREFOR

Centrix, Inc., Shelton, ...

1. A package for containing and dosing pre-dosed applicators comprising:a container having a bottom and a top with a container depth from the bottom to the top of said container;
an absorbent pad placed adjacent the bottom, said absorbent pad having an initial dry compressed thickness and a subsequent expanded wet thickness;
a solution containing a material placed on the absorbent pad;
a plurality of applicators, each of said plurality of applicators having an applicator length and an absorbent end placed in the container, wherein the absorbent end is placed adjacent said absorbent pad;
wherein the applicator length combined with the initial dry compressed thickness of said absorbent pad is less than the container depth and the applicator length combined with the subsequent expanded wet thickness of said absorbent pad is greater than the container depth; and
a lid placed over the top of the container.

US Pat. No. 10,426,703

VIAL ADAPTERS

UNL Holdings LLC, New Yo...

1. A method of transferring fluid from a vial comprising a closure to a safety syringe, said method including connecting a vial adapter to the closure of the vial and to the safety syringe, fitting lateral arms of the vial adapter to the closure so that the vial adapter is in fluid communication with said safety syringe and inserting a conduit tip of the vial adapter into the safety syringe, the conduit tip inhibiting travel of a plunger of the safety syringe towards a distal end of the safety syringe.

US Pat. No. 10,426,702

MIXING AND/OR TRANSFERRING DEVICE

1. A device for mixing or transferring a first substance and a second substance that are present, respectively, in a first and a second receptacle, comprising:a first adapter having a circumferential wall, and being configured to accept the first receptacle, and along which extends, and which, at least in sections, surrounds a first cannula body, and a first hollow-cylindrical section connected to the first cannula body,
a second adapter having a circumferential wall, and being configured to accept the second receptacle, and along which extends, and which, at least in sections, coaxially surrounds, a second cannula body, and a second hollow-cylindrical section connected to the second cannula body,
wherein, in an assembled state, the first hollow-cylindrical section inter-engages with the second hollow-cylindrical section, and the first adapter and the second adapter are screwably and detachedly connected,
wherein each of the first and the second adapters comprises a hollow-cylindrical outer body with an exterior circumferential wall, and a partition wall extending perpendicularly to a longitudinal axis of the outer body,
wherein, when the first and second adapters are assembled together, a section, which has an inner thread, of the outer circumferential wall of one of the first and the second adapters surrounds a section, which has an external thread, of the outer circumferential wall of the other of the first and the second adapters, with inter-engaging threaded sections,
wherein the hollow-cylindrical outer body of at least one of the first and second adapters comprises an insert, having a circumferential wall, that accepts the first or the second receptacle, and
wherein the circumferential wall of the insert extends, at least in sections of the interior surface of the outer circumferential wall, spaced-apart from the interior surface of the outer circumferential wall.

US Pat. No. 10,426,701

SINGLE USE CONNECTORS

MEDINSTILL DEVELOPMENT LL...

1. A connector comprising:a first piece;
a piercing member attached to the first piece; and
a second piece, the piercing member being slidingly receivable within the second piece;
wherein the piercing member and the second piece are movable relative to each other between a first position where the second piece closes a flow port and a second position where the flow port is open;
the first piece further including a locking mechanism adapted to lockingly connect the first piece to a device when engaged therewith, thereby preventing subsequent disconnection and disengagement of the first piece and the device.

US Pat. No. 10,426,700

SYRINGE ACCESSORY FOR TRANSFER OF AIR SENSITIVE MATERIALS

International Business Ma...

1. An apparatus for transferring fluid contained in a syringe, comprising:an airlock component having a cylindrical body, the cylindrical body having a first end, a second end, and a hollow tube disposed between the first end and the second end, wherein the hollow tube has an interior surface and an exterior surface;
an annular opening at the first end of the cylindrical body;
a gas inlet aperture from the exterior surface of the hollow tube to the interior surface of hollow tube;
a gas outlet aperture from the interior surface of the hollow tube to the exterior surface of the hollow tube;
an inwardly-facing airtight material coupled to the interior surface of the hollow tube; and
a septum coupled to the second end of the cylindrical body.

US Pat. No. 10,426,698

PILL CONTAINER WITH CAP

Breeden Brothers, LLC, N...

1. A pill container comprisingan outer shell having a flat bottom section and an angled corner section, the angled corner section having an opening for dispensing pills, wherein the outer shell includes a first shell section and a second shell section that snap together to form the outer shell;
a bottle disposed within the outer shell, wherein the first shell section and the second shell section snap together around the bottle to enclose all but a spout of the bottle;
a constriction within the bottle configured to reduce flow of the pills out from the pill container, and
a cap formed in substantially triangular shape, the cap configured to screw onto the bottle and seal the opening of the outer shell, wherein the cap includes a raised section having a notch, the notch configured to pass over and engage with a raised insert protruding from the bottle as the cap is turned.

US Pat. No. 10,426,697

COMPACT ELECTRO-MECHANICAL CHEST COMPRESSION DRIVE

Koninklijke Philips N.V.,...

1. A cardio-pulmonary compression device, comprising:a motor having a rotating portion;
a ball nut mounted on the rotating portion and configured to rotate with the rotating portion;
a ball screw being received in the ball nut such that rotation on the ball nut advances and/or retracts the ball screw in accordance with a direction of the motor;
a pad assembly coupled to an end portion of the ball screw such that longitudinal motion of the ball screw imparts a compression cycle to a patient.

US Pat. No. 10,426,696

DEFIBRILLATOR DISPLAY INCLUDING CPR DEPTH INFORMATION

ZOLL Medical Corporation,...

1. An external defibrillator system for treatment of a patient, comprising:one or more compression sensors for measuring chest compression information and producing chest compression signals based on the measured chest compression information;
one or more physiological sensors for measuring physiological information and producing physiological signals based on the measured physiological information; and
at least one processor configured to:
receive and process the chest compression signals and the physiological signals,
determine values for chest compression depth and/or chest compression rate based on the received chest compression signals,
determine a trend of at least one physiological parameter over a period comprising multiple chest compressions based on the received physiological signals,
adjust a target chest compression depth and/or target chest compression rate based on the determined trend of the at least one physiological parameter,
compare the determined values for chest compression depth and/or chest compression rate to the adjusted target compression depth and/or the adjusted target compression rate, and
provide feedback about the quality of chest compressions performed on the patient based on the comparison between the determined values for chest compression depth and/or chest compression rate to the adjusted target compression depth and/or the adjusted compression rate.