US Pat. No. 10,137,281

CATHETER FOR TREATMENT OF SINUSITIS

Tsukada Medical Research ...

1. A catheter for treatment of sinusitis comprising:an anterior nasal aperture balloon;
an anterior nasal aperture balloon air supply lumen for inflating the anterior nasal aperture balloon;
a posterior nasal aperture balloon;
a posterior nasal aperture balloon air supply lumen for inflating the posterior nasal aperture balloon;
a drainage lumen having an opening between the anterior nasal aperture balloon and the posterior nasal aperture balloon;
a drainage catheter comprising the anterior nasal aperture balloon air supply lumen and the drainage lumen therein;
a posterior nasal aperture balloon catheter comprising the posterior nasal aperture balloon air supply lumen therein; and
an external air communication lumen having an opening on a distal side from the posterior nasal aperture balloon is further provided in the posterior nasal aperture balloon catheter,
wherein the catheter comprising the external air communication lumen is formed of silicone rubber,
wherein the drainage catheter and the posterior nasal aperture balloon catheter are arranged in a side-by-side configuration,
wherein a distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is adjustable, and
wherein adjustment of the distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is realized by an internal space having a circular section formed in the anterior nasal aperture balloon through which the posterior nasal aperture balloon catheter passes, and at least one annular sealing rib formed on a wall surface which surrounds the internal space, and the at least one annular sealing rib is configured to seal an annular gap between an outer surface of the posterior nasal aperture balloon catheter and the wall surface such that liquid does not pass through the annular gap between the outer surface and the wall surface.

US Pat. No. 10,137,278

CANNULA STABILIZATION DEVICE

1. A cannula stabilization device comprising:a bearing platform;
a tubing holder located on a first end of the bearing platform;
a tubing holder located on a second end of the bearing platform opposite the first end, wherein each tubing holder is configured to secure and route continuous tubing, and wherein the tubing is configured to intersect the bearing platform only at each tubing holder;
a rotational joint fixedly attached to the bearing platform on a bottom side of the bearing platform; and
a helmet releasably attachable to the rotational joint;
wherein the helmet and the bearing platform are independently rotatable around a common rotational axis when the helmet is attached to the rotational joint.

US Pat. No. 10,137,276

SYSTEM AND METHOD FOR SLEEP SESSION MANAGEMENT BASED ON SLOW WAVE SLEEP ACTIVITY IN A SUBJECT

Koninklijke Philips N.V.,...

1. A system configured to manage a sleep session of a subject, the system comprising:one or more sensory stimulators configured to provide sensory stimuli to the subject;
one or more sensors configured to generate output signals conveying information related to a current sleep stage of the subject during the sleep session; and
one or more processors configured by machine-readable instructions to:
determine a dissipation threshold level for triggering a sensory waking stimulus;
obtain, during the sleep session, the output signals from the one or more sensors, at least some of the output signals being related to slow wave activity in the subject;
monitor, during the sleep session, the slow wave activity based on the output signals;
determine, based on the monitoring of the slow wave activity, a rate of change in the slow wave activity over time with respect to the sleep session;
determine a sleep pressure dissipation level of the subject based on the rate of change in the slow wave activity, the sleep pressure dissipation level being a metric indicating a level of dissipation with respect to sleep pressure of the subject, the sleep pressure indicating the subject's remaining need for sleep; and
responsive to the sleep pressure dissipation level breaching the dissipation threshold level, control the one or more sensory stimulators to generate the sensory waking stimulus to cause the subject to wake from the sleep session.

US Pat. No. 10,137,274

PATIENT INTERFACES

1. A patient interface comprising:a mask assembly configured to be coupled with an elbow assembly for delivering a pressurized gas to a patient;
the elbow assembly comprising:
a first leg configured to connect to a source of the pressurized gas at a first end of the elbow assembly; and
a second leg configured to swivelably connect to the mask assembly, the second leg comprising:
a second end of the elbow assembly configured to insertably interface with the mask assembly;
an outer conduit and an inner conduit fixed within the outer conduit, a first tubular section of the outer conduit disposed radially outward of a second tubular section of the inner conduit, the inner conduit and the outer conduit extending towards the second end of the elbow assembly from a front wall of the outer conduit, a distal end of the outer conduit disposed beyond a distal portion of the second tubular section of the inner conduit in an axial direction such that the distal portion of the second tubular section is disposed within a straight section of the second leg;
a first flow path defined between the inner conduit and the outer conduit, the first flow path accommodating a first flow of gases in a first direction;
a second flow path defined within the inner conduit, the second flow path accommodating a second flow of gases in a second direction, the first direction being directly opposite the second direction in at least a portion of the second leg; and
a diffuser comprising a plurality of exhaust vents in the front wall of the outer conduit.

US Pat. No. 10,137,273

PATIENT INTERFACES

1. A patient interface for use as part of a system for delivering a supply of gases to a patient comprising:a hollow body configured to be disposed on the patient's face in use and configured to deliver gases to the patient, said hollow body comprising an aperture extending from an inside of the hollow body to an outside of said hollow body; and
an elbow connector comprising a first end configured to be connected to a gas supply conduit, a second end configured to be swivelably connected to said aperture of said hollow body, and an exhaust port positioned between said first end and said second end, said exhaust port comprising a plurality of outlet vent holes extending through an outer wall of the elbow connector, and at least one wall at least partially defining an exhaust passage and extending from said exhaust port toward said second end, and said at least one wall being interposed between said exhaust passage and a delivery passage extending from said first end of said elbow connector to said second end of said elbow connector such that incoming gases are separated from said exhaust passage by said at least one wall, wherein said wall forms an enclosed perimeter such that a space within the wall is separated from a space that completely surrounds the wall, and wherein the wall extends in a direction aligned with the second end of the elbow connector;
wherein said at least one wall is rigid and fixed in position inside said elbow connector.

US Pat. No. 10,137,271

NASAL INTERFACE

1. A nasal interface for use in a system for providing a flow of respiratory gases to a user, the nasal interface comprising:a body made from a pliable first material, the body comprising an inlet configured to receive a flow of gases and at least one nasal outlet, the at least one nasal outlet comprising a tubular structure configured to interface with a user's nostril, the at least one nasal outlet being fluidly connected to the inlet, wherein at least one plastically deformable member is attached to or integrally formed with the body, the at least one plastically deformable member having an elastic limit less than the elastic limit of the pliable first material; and
a flow restrictor comprising a member coupled to the body in a fixed position, the flow restrictor blocking a center of the flow of gases through the body and defining a gradually reducing cross sectional flow area such that all flow into and through the body passes through and is thereby restricted by the flow restrictor, wherein the flow restrictor is a dominant flow restriction of all gases flow in the system.

US Pat. No. 10,137,270

CUSHION TO FRAME ASSEMBLY MECHANISM

ResMed Limited, Bella Vi...

1. A mask assembly for treatment of sleep disorder breathing by delivering a flow of pressurized gas to a patient, the mask assembly comprising:a first frame including a first wall that at least partially delimits a breathing chamber, a second wall surrounding an opening through the first wall and defining a first substantially cylindrical surface surrounding the opening and defining a central axis, the second wall extending from the first wall, the opening being configured to allow the flow of pressurized gas to the breathing chamber;
a second frame including a third wall that is cylindrical and defines a second substantially cylindrical surface, a fourth wall, a member extending toward a forehead support and two headgear attachment locations, the third wall extending away from the fourth wall, the second substantially cylindrical surface at least partially overlapping with and passing completely around the first substantially cylindrical surface, and the second frame being configured to removably interlock with the first frame proximate the opening when the first frame and the second frame are moved towards one another along the central axis; and
a cushion molded to the first frame and including a side wall and a membrane adapted to seal around a patient's nose, the membrane being connected to the side wall at an outer periphery of the membrane and being unconnected at an inner periphery of the membrane; wherein
the membrane is on an opposite side of the first frame with respect to the opening,
the first frame comprises a first material and the cushion comprises a second material that is more flexible than the first material and the first wall and the second wall comprise the first material.

US Pat. No. 10,137,269

CUSHION-TO-FRAME COMPONENT FOR AN INTERFACING STRUCTURE

RESMED LIMITED, Bella Vi...

1. An interfacing structure for a mask system, comprising:a cushion component adapted to contact the patient's face in use; and
a cushion-to-frame component provided to the cushion component, the cushion-to-frame component structured to secure the cushion component to a mask frame of the mask system,
the cushion-to-frame component including a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame,
wherein the cushion side includes a platform including an inner flange and an outer flange provided to opposing ends of the platform and an engagement surface between the inner flange and the outer flange to engage the cushion component, and
wherein the engagement surface is non-linear along its width and includes incline portions, decline portions, and flat portions along its width.

US Pat. No. 10,137,268

SYSTEM AND METHOD FOR SECURING A BREATHING GAS DELIVERY HOSE

CPAP Miracle LLC, Beachw...

1. A device comprising:a substantially rigid, elongated contiguous, tubular support member comprised of a tube wall having a first distal end, a second distal end, and a centralized living hinge biasing portion, integrated in the tube wall and comprised of a series of spaced apart slits in the tube wall, the living hinge, configured to bias arcuate movement between the first distal end and the second distal end, and wherein
the living hinge has an axial length smaller than axial lengths of the first and second distal ends,
a bias of the living hinge is configured to be adjustable while maintaining a fixed distance between the first and second distal ends, and
the bias of the living hinge corresponds to a position of an outer tube disposed circumferentially along a surface of the tube so as to be slide-able relative to the biasing portion;
a generally planar, rigid base configured to receive an associated pillow on an upper surface thereof so as to secure the first distal end so that the support member extends from a surface of the base to hold the first distal end in a generally vertical position relative to the second distal end when a radial force is applied to the second distal end during flexure of the living hinge;
a mount comprised of first and second coaxial, biased C-clips secured to the second distal end, the mount configured to snap fit an associated tube thereto with substantially unrestricted fluid flow therethrough; and
a mount support, formed from a cutaway portion of the tube wall, extending radially outwardly from the tube.

US Pat. No. 10,137,267

TRACHEOSTOMY TUBES

SMITHS MEDICAL INTERNATIO...

1. A tracheostomy tube having a shaft with a length, a patient end, a machine end and a fenestrated region locating substantially midway along the length and spaced from the machine end and the patient end including at least one opening at a location adapted to lie within the trachea, characterized in that the shaft is formed of a first material that is relatively soft and that the fenestrated region of the tube is formed only by a plate that includes the at least one opening, the plate formed of a second material that is stiffer than the first material to increase the overall stiffness of the shaft at the fenestrated region such that the portion of the shaft between the patient end of the tube and the patient end of the plate is more flexible than the fenestrated portion.

US Pat. No. 10,137,266

PATIENT-VENTILATOR DYSSYNCHRONY DETECTION

KONINKLIJKE PHILIPS N.V.,...

1. A method of detecting dyssynchrony between a patient and a pressure support system, comprising:receiving patient flow data representing a patient flow waveform, the patient flow waveform representing a flow of gas provided to the patient by the pressure support system;
obtaining an I/E state signal indicating whether a current respiratory phase of the patient is inspiratory or expiratory, the I/E state signal being in binary form and having only a first binary state and a second binary state, the first binary state indicating that the current respiratory phase is inspiratory and the second binary state indicating that the current respiratory phase is expiratory; and
analyzing both the patient flow data and the I/E state signal for a breath to determine whether at least one of a number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal and declaring a dyssynchrony for the breath and outputting a dyssynchrony indicator if it is determined that at least one of the number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal, wherein the dyssynchrony is a condition where a respiratory drive of the patient is out of sync with breaths being generated by the pressure support system, wherein the number of predetermined criterion includes all of; (i) a number of volume qualified flow slope reversals in the patient flow data for the breath exceeding a predetermined number; (ii) an incremented tidal volume during at least a portion of an expiratory phase of the breath as indicated by the I/E state signal exceeding a predetermined positive value; (iii) an absolute value of a tidal volume during the breath exceeds a predetermined value; and (iv) a tidal volume during an inspiratory phase of the breath as indicated by the I/E state is less than a predetermined negative value.

US Pat. No. 10,137,265

SYSTEMS AND METHODS FOR WIRELESS FEEDBACK DURING VENTILATION

ZOLL MEDICAL CORPORATION,...

1. A system for providing feedback on delivery of cardiopulmonary resuscitation (CPR), the system comprising:a manual patient ventilation unit defining an airflow path, the unit arranged so that when the unit is applied to a patient, the airflow path is in fluid communication with the patients airway, the patient ventilation unit comprising:
a ventilation bag configured to enable manual ventilation of the patient by a rescuer;
at least one first sensor in the airflow path positioned to sense the presence of ventilation airflow and measure a gas flow rate in the airflow path; and
at least one second sensor in the airflow path positioned to sense gas pressure in the airflow path;
at least one chest compression sensor configured to detect and measure compression information based on chest compressions applied to the patient; and
a feedback unit separate from the manual patient ventilation unit comprising a processor arranged to:
wirelessly receive data generated by the at least one first sensor and the at least one second sensor;
determine one or more ventilation quality parameters based at least in part on a gas flow volume calculated based on the sensed gas flow rate and gas pressures;
receive compression data generated by the at least one chest compression sensor;
determine one or more chest compression parameters based at least in part on the measured compression information; and
provide both ventilation feedback and chest compression feedback to a rescuer, the ventilation feedback comprising the one or more ventilation quality parameters and instructions for performing ventilations based upon a comparison of the ventilation quality parameters with a ventilation protocol comprising ranges of predetermined acceptable values for administering ventilations to the patient and the chest compression feedback comprising the one or more chest compression parameters and instructions for performing chest compressions based upon a comparison of the chest compression parameters with a chest compression protocol comprising ranges of predetermined acceptable values for administering chest compressions to the patient,
wherein the ventilation quality parameters comprise one or more of tidal volume, minute volume, end-inspiratory pressure, and maximum ventilation pressure.

US Pat. No. 10,137,264

RESPIRATORY ASSISTANCE APPARATUS

1. A head-mounted respiratory assistance apparatus configured to provide a respiratory gases stream to a user, comprising:a main body securable to the head of a user;
a blower unit provided on the main body having a gases inlet to receive a supply of gases from the surrounding atmosphere and which is operable to generate a pressurised gases stream at a gases outlet, wherein the blower unit comprises a casing and wherein the gases outlet extends radially outward from a center of the casing; and
a patient interface provided on the main body having a gases inlet which is fluidly connected via a gases flow path to the gases outlet of the blower unit and which is configured to deliver the pressurised gases to the user's nose and/or mouth via one or more gases outlets,
wherein the gases flow path from the gases inlet of the blower unit to the gases outlet(s) of the patient interface is substantially sealed such that there is zero bias flow along the gases flow path, and
wherein the blower unit comprises a lightweight shroudless impeller, wherein the impeller comprises a plurality of separated impeller blades extending outward from a central hub of the impeller, and a motor with a rotatable drive shaft that is configured to rotate the impeller.

US Pat. No. 10,137,263

APPARATUS AND METHOD FOR MONITORING AN AIRWAY DEVICE SUCH AS AN ENDOTRACHEAL TUBE

Indian Ocean Medical Inc....

1. A method of detecting a leak of fluid from an inflatable airway device in a closed volume pressure system, the method comprising:periodically receiving a pressure value for the inflatable airway device from a pressure sensor in a pressure control and monitoring apparatus in the closed volume pressure system;
in a processor of the pressure control and monitoring apparatus, comparing the received pressure value with a setpoint value to determine a difference between the received pressure value and the setpoint value;
calculating in the processor if the difference is within a predefined tolerance band of the setpoint value;
calculating in the processor a rate of change of volume as a number of steps of a stepper motor in the closed volume pressure system required to correct the difference between the received pressure value and the setpoint value;
if the received pressure value is higher than the predefined tolerance band, setting the number of steps of the stepper motor as negative, if the received pressure value is lower than the predefined tolerance band, setting the number of steps of the stepper motor as positive, and driving the stepper motor the number of steps required to correct the difference between the received pressure value and the setpoint value;
calculating in the processor a statistical average of the rate of change of volume calculated using the received pressure value and a predetermined number of previously received pressure values to indicate whether significant changes have been necessary over a preceding time interval to increase pressure to the setpoint value;
determining if the statistical average is greater or lower than a threshold value, wherein the threshold value is a minimum average value that is indicative of an ineffective operation of pressure regulation in response to pressure reduction arising during normal usage of a patient and the minimum average value represents an average value for a breathing cycle, including inflation, deflation, and static steps, over a predetermined number of seconds; and
if the statistical average is greater than the threshold value, activating an alarm in the pressure control and monitoring apparatus to indicate a leak of fluid from the airway device.

US Pat. No. 10,137,262

SYNCHRONIZING MECHANICAL IN-EXSUFFLATION AND DIAPHRAGMATIC PACING

KONINKLIJKE PHILIPS N.V.,...

1. A system for synchronizing machine-induced inexsufflation with a diaphragmatic pacing of a subject, the system comprising;a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
one or more sensors configured to generate one or more output signals conveying information related to one or both of
i) one or more gas parameters of a flow of breathable gas being breathed by the subject and/or
ii) one or more respiratory parameters of the subject; and
one or more processors configured to execute computer program modules, the computer program modules comprising:
a configuration module configured to obtain one or more configurable operational settings of the diaphragmatic pacing of the subject;
a detection module configured to detect onsets of inhalations of the subject such that, for a first respiratory cycle, the detection module detects an onset of a first inhalation of the subject based on the one or more output signals, wherein the first inhalation is included in the first respiratory cycle;
a target module configured to determine a target parameter for machine-induced inexsufflation during respiratory cycles such that, responsive to detection of the onset of the first inhalation, the target module determines the target parameter for machine-induced inexsufflation during a second respiratory cycle such that the machine-induced inexsufflation occurs in synchrony with the diaphragmatic pacing of the subject, wherein the second respiratory cycle is subsequent to the first respiratory cycle, and wherein the target parameter corresponds to an onset of inhalation during the second respiratory cycle or an onset of exhalation during the second respiratory cycle; and
a control module configured to control the pressure generator to inexsufflate the subject such that during the second respiratory cycle the control module controls the pressure generator to inexsufflate the subject in accordance with the target parameter for machine-induced inexsufflation, wherein:
inexsufflating the subject comprises controlling the pressure generator to generate a pressure cycle providing a positive pressure during a first time period, a negative pressure during a second time period, and a pause in pressure generation during a third time period, wherein the third time period occurs subsequent to the second time period and the second time period occurs subsequent to the first time period; and
at least two of the first, second, or third time periods are adjusted based on the target parameter in one or more subsequent pressure cycles to enhance synchronization of the machine-induced inexsufflation with the diaphragmatic pacing over multiple pressure or respiratory cycles.

US Pat. No. 10,137,261

INHALATOR

LK INVESTMENT APS, Humle...

1. An inhalator comprising a housing with at least a first compartment and a second compartment, and including one or more substances, and a release device, said second compartment including at least one air entry port, said inhalator having a first proximal end of said first compartment and a second proximal end of said second compartment and a first distal end of the first compartment, a second distal end distal of the second compartment, the at least one entry port is at the second distal end, an inhalation part being at said second proximal end, said first compartment being for storing at least one substance and including in an inoperative state of said inhalator a plurality of sealing bodies arranged in a neighboring relationship, without the release device inserted into the housing, wherein being proximal is closest to a mouth of a user and being distal is furthest away from the mouth of said user;wherein at least one pair of neighboring sealing bodies defines at least in part a sealed chamber for containing a substance, said at least one pair of neighboring sealing bodies being movable together with said at least one substance from said first compartment into said second compartment to define an operative state of said inhalator;
said operative state of the inhalator being a state;
wherein said one or more substances are contained and are allowed to mix and blend in said second compartment;
the release device is in the first compartment, and
air entering through said at least one air entry port obtains at least a part of said at least one substance contained in said second compartment and is inhaled through said inhalation part while the release device is in the first compartment; and
wherein said release device is for moving at least one of the sealing bodies from the first compartment to the second compartment when being inserted into the first compartment from the first distal end, and is configured to allow said air to flow to said at least one air entry port in the operative state, and the second compartment is located between the inhalation part and the first compartment.

US Pat. No. 10,137,259

PORTABLE ULTRASONIC NEBULIZER AND NEBULIZATION STRUCTURE THEREOF

HCMED INNOVATIONS CO., LT...

1. A nebulization structure, comprising:a carrier unit having a first carrier portion, a first surrounding portion extended outward from an outer perimeter of the first carrier portion, a second carrier portion extended outward from an outer perimeter of the first surrounding portion, and a second surrounding portion extended outward from an outer perimeter of the second carrier portion, wherein the first carrier portion has a through hole, and the first surrounding portion, the second carrier portion and the second surrounding portion are sequentially connected to form a surrounding groove, wherein the first surrounding portion is extended backward and slantwise from the outer perimeter of the first carrier portion;
a vibration unit including an annular vibrating sheet received in the surrounding groove;
a waterproof package unit received in the surrounding groove to enclose the annular vibrating sheet;
a nebulization unit disposed on the first carrier portion, wherein the nebulization unit has a plurality of micro holes communicated with the through hole; and
a position-limiting unit having a first position-limiting portion disposed on the nebulization unit and a second position-limiting portion extended outward and slantwise from an outer perimeter of the first position-limiting portion and along the first surrounding portion, wherein the nebulization unit is positioned between the first carrier portion and the position-limiting unit, and the first position-limiting portion has an opening for exposing the micro holes.

US Pat. No. 10,137,257

SLACK-TIME HEATING SYSTEM FOR BLOOD AND FLUID WARMING

Belmont Instrument, LLC, ...

1. A system for heating an infusate, the system comprising:a reservoir for containing an infusate;
an induction fluid heater comprising a circular single flow path therewithin;
a diversion valve;
a patient line; and
a recirculation line,
wherein the induction fluid heater comprises an inlet to receive the infusate from the reservoir and to direct the infusate to the circular single flow path,
wherein the induction fluid heater comprises an outlet to direct a heated infusate from the circular single flow path into the patient line and/or the recirculation line,
wherein the diversion valve operates to direct the heated infusate from the induction fluid heater into the patient line and/or the recirculation line, said diversion valve controlling a ratio of a flow in the patient line to a flow in the recirculation line,
wherein the patient line directs the heated infusate to a patient, and
wherein the recirculation line directs the heated infusate to the reservoir, so that the system increases a temperature of the infusate in the reservoir.

US Pat. No. 10,137,256

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case adapted to hold a medicament container having a needle;
a needle shroud telescopically coupled to the case and movable between a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered and the needle shroud is inhibited from translating relative to the case; and
a plunger slidably disposed in the case and movable between a proximal position, an intermediate position and a distal position relative to the case,
wherein, when the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the first extended position, and
wherein, when the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.

US Pat. No. 10,137,255

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case having a rib;
a needle shroud telescopically coupled to the case and movable between a first extended position, a retracted position and a locked second extended position;
a carrier slidably arranged in the case and adapted to hold a medicament container, the carrier movable from a first axial position to a second axial position relative to the case;
a collar rotatably and slidably disposed in the case, the collar coupled to the needle shroud and the carrier; and
a control spring biasing the collar in a distal direction relative to the case,
wherein the collar is adapted to abut the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar is adapted to disengage the rib when the needle shroud is in the retracted position and the carrier is in the second axial position,
wherein the collar includes a shroud boss adapted to engage a shroud slot in the needle shroud, a carrier boss adapted to engage a carrier slot in the carrier, and a case boss adapted to engage the rib in the case,
wherein the collar is adapted to couple a force of the control spring to one of the carrier, the needle shroud and the case based on axial and rotational positions of the needle shroud, the carrier, and the rib in the case relative to the collar.

US Pat. No. 10,137,254

TELESCOPIC DRIVE ARRANGEMENT FOR DRUG DELIVERY DEVICE

1. A drug delivery device, comprising:a compartment adapted to receive and hold a drug-filled cartridge having an axially moveable piston,
a support structure,
a drive tube comprising an inner thread,
a motor assembly having a distal portion and a proximal portion, the distal portion comprising a rotatable drive shaft and being adapted to be received inside the drive tube,
a drive member comprising an outer thread, and
a controller for controlling the motor assembly,wherein:the drive member outer thread is in threaded engagement with the drive tube inner thread,
the motor assembly is arranged non-rotational relative to the support structure,
the drive tube is arranged axially displaceable but non-rotational relative to the motor assembly and is adapted to engage and axially move, directly or indirectly, the piston of a loaded cartridge to thereby expel drug from the cartridge,
the motor assembly proximal portion is connected to the support structure via a first flexible joint, and
the drive shaft is connected to the drive member via a second flexible joint,whereby rotation of the drive shaft results in axial, non-rotational displacement of the drive tube relative to the support structure.

US Pat. No. 10,137,252

PEN-SHAPED TORSION SPRING DRIVEN INJECTION DEVICE

1. A pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug comprising:A housing having a window,
A piston rod having an external thread,
A rotatable piston rod guide engaging and driving the piston rod during dose expelling,
A torsion spring for rotating the piston rod guide,
A rotatable scale drum having a thread engaging the external thread of the piston rod and carrying a plurality of indicia viewable through the window of the housing,
A rotatable dose setting member cooperating with the scale drum such that rotation of the dose setting member during dose setting is transformed to a rotation of the scale drum, and whereinthe piston rod is held inrotatable during dose setting whereby the scale drum rotates helically on the external thread of the piston rod.

US Pat. No. 10,137,251

ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An assembly for a drug delivery device, comprising:a compression spring, wherein the compression spring is compressed during a setting of a dose of a drug;
a sleeve member,
a rotation member, wherein the sleeve member is rotationally fixed and axially moveable with respect to the rotation member;
a dose setting member which is configured to be rotated in a dose setting direction in order to set a dose, wherein a rotation of the dose setting member in the dose setting direction causes a rotation of the rotation member in the dose setting direction, wherein the rotation member is coupled to the dose setting member by means of a drive shaft;
an actuator which is configured to be operated in order to dispense the dose of the drug, wherein the compression spring is enabled to relax when the actuator is operated; and
a locking member which is configured to inhibit a rotation of the rotation member in a dose dispensing direction during the setting of the dose, thereby inhibiting a relaxation of the compression spring,
wherein the compression spring abuts the sleeve member and wherein the compression spring and the sleeve member are configured such that the relaxation of the compression spring effects a rotational movement and an axial movement of the sleeve member in a proximal direction away from a dispensing end of the drug delivery device, thereby causing a dispensing of the dose from the drug delivery device, and wherein the assembly further comprises a housing, wherein the compression spring is arranged between a bearing surface of the housing and the sleeve member, and wherein the compression spring exerts a force on the sleeve member which is directed in the proximal direction.

US Pat. No. 10,137,250

SYRINGE AND PREFILLED SYRINGE

TERUMO KABUSHIKI KAISHA, ...

1. A syringe comprising:a cylindrically-shaped gasket comprising a closed distal end, an open proximal end, and an inner cavity portion extending distally from a proximal side;
a barrel comprising a distal opening portion and configured to slidably contain the gasket; and
a plunger comprising a head portion configured to be contained in the inner cavity portion of the gasket,
wherein the head portion comprises:
a shaft portion, and
a helical rib located at an outer surface of the shaft portion, the helical rib comprising a starting end on a distal side and a terminal end on a proximal side,
wherein the gasket comprises, on an inner surface of the inner cavity portion, a helical crest portion forming a helical valley portion configured to threadedly engage with the helical rib of the plunger, and a plunger-retaining annular rib positioned distally from the helical crest portion, wherein the inner cavity portion further comprises an accommodation portion positioned distally from the plunger-retaining annular rib, the accommodation portion configured to contain a part of the head portion of the plunger at which the helical rib is formed, and wherein the plunger-retaining annular rib further comprises a rib absent portion configured to guide, to the accommodation portion, the helical rib reaching the plunger-retaining annular rib as threaded engagement is advanced between the plunger and the gasket,
wherein the plunger comprises, at the terminal end of the helical rib, an entrance-restricting terminal end portion configured to restrict the entrance of the helical rib into the rib absent portion after the part of the plunger at which the helical rib is formed is contained in the accommodation portion of the gasket,
wherein the helical rib includes a proximal surface extending outward from the shaft portion, a distal surface extending outward from the shaft portion, and an outer surface extending between the proximal surface to the distal surface, and
wherein the entrance-restricting terminal end portion comprises a terminal end surface that extends (i) between the proximal surface of the helical rib and the distal surface of the helical rib, and (ii) between the shaft portion and the outer surface of the helical rib.

US Pat. No. 10,137,249

PRIMING CONFIGURATION FOR A MEDICAL DEVICE AND DRUG DELIVERY DEVICE COMPRISING A PRIMING CONFIGURATION

Sanofi, Paris (FR)

1. A priming configuration for a medical device, the priming configuration comprising:a piston rod configured to operate the device; and
a movable element comprising an inclined surface being arranged to engage the piston rod, wherein the inclined surface is arranged to be movable in a transverse direction with respect to the piston rod by a user of the medical device, wherein the inclined surface slides along the piston rod during a movement of the inclined surface in the transverse direction, and wherein the movement of the inclined surface in the transverse direction from one end of the inclined surface to an opposite end of the inclined surface causes the engagement of the inclined surface and the piston rod to advance the piston rod in a further direction different from the transverse direction thereby providing a priming of the medical device before use.

US Pat. No. 10,137,247

APPARATUS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS TO MUCOUS OR SEROUS MEMBRANE

1. A method, comprising:receiving from a sensor at least one body signal from a patient;
detecting a condition of said patient based on said body signal, said detecting a condition being detected by a therapy device; and
administering a therapy with said therapy device to at least one of a mucous membrane or a serous membrane of said patient, in response to said detecting; wherein said body signal is a signal indicative of a concentration of a therapeutic medication in a body fluid; said condition is said concentration of said therapeutic medication being above a second concentration; and said therapy comprises at least one of reducing a dose of said therapeutic medication, reducing a rate of delivery of said therapeutic medication, or delaying a delivery of said therapeutic medication.

US Pat. No. 10,137,245

CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY

University of Florida Res...

1. A system for monitoring and control for safe administration, reduction or cessation of administration of at least one of medication to a subject, comprising:(a) at least one photoplethysmography (PPG) sensor adapted to secure to a central source site of the subject;
(b) an infusion pump for delivering the at least one medication to the subject, wherein the infusion pump comprises an infusion controller for increasing or decreasing flow of medication to the subject; and
(c) an infusion pump agnostic safety device that is adapted to be deployed onto tubing adapted to deliver the at least one medication from the infusion pump to the subject, wherein the safety device comprises an occlusion apparatus and an occlusion controller, wherein the occlusion controller receives signals from the PPG sensor, calculates at least one respiratory parameter based on the signals from the PPG sensor, and if the at least one respiratory parameter is determined by the occlusion controller to be adverse, the occlusion controller directs the occlusion apparatus to partially or completely occlude the tubing
wherein the infusion pump agnostic safety device only occludes the tubing in the event the occlusion controller determines that an adverse event has occurred.

US Pat. No. 10,137,244

MICROFLUIDIC DRUG DELIVERY DEVICES WITH VENTURI EFFECT

ALCYONE LIFESCIENCES, INC...

1. A microfluidic convection-enhanced-delivery (CED) device, comprising:a shank portion;
at least one fluid delivery conduit having a proximal end, a distal end, a fluid inlet port, and at least one fluid outlet port, the at least one fluid delivery conduit being formed in or on the shank portion, the at least one fluid delivery conduit comprising first and second upstream lumens and a single downstream lumen;
a flow restriction formed within the at least one fluid delivery conduit at a merge of the first and second upstream lumens into the single downstream lumen, the flow restriction being configured to adjust a pressure of fluid being directed through the at least one fluid delivery conduit;
wherein the flow restriction comprises a constricted region of the at least one fluid delivery conduit having a cross-sectional area that is less than a cross-sectional area of a proximally-adjacent portion of the at least one fluid delivery conduit;
wherein the at least one fluid outlet port includes a plurality of fluid outlet ports formed in the first and second upstream lumens and a plurality of fluid outlet ports formed in the single downstream lumen; and
wherein the plurality of fluid outlet ports formed in the first and second upstream lumens are formed in an outermost surface of the microfluidic CED device and disposed such that fluid exits from the first and second upstream lumens directly to a location exterior to the microfluidic CED device.

US Pat. No. 10,137,242

FLUID DISPENSING DEVICE WITH A FLOW DETECTOR

Roche Diabetes Care, Inc....

1. A portable therapeutic fluid delivery device for delivering a therapeutic fluid into a body of a patient, the fluid delivery device comprising:a first part comprising,
a driving mechanism,
a flow detector comprising at least one heating element and at least two temperature sensors, and
a processor;
a second part comprising,
a reservoir,
an exit port, and
a delivery tube communicating between the reservoir and the exit port;
wherein the first part and the second part are designed such that upon pairing of the first part with the second part, the at least one heating element and the at least two temperature sensors touch the delivery tube, and wherein the processor, upon activation of the at least one heating element, determines a flow condition of the therapeutic fluid inside the delivery tube based on signals provided by the at least two temperature sensors.

US Pat. No. 10,137,241

AUTOMATED INSERTION ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

1. An automated insertion system comprising:a cartridge assembly comprising:
a toothed track;
a toothless groove; and
at least one dermal perforation assembly having an interior passage configured to releasably engage at least a portion of a subdermal device therein; and
an actuation assembly configured to drive the at least one dermal perforation assembly a predetermined distance, the actuation assembly comprising:
a drive gear set comprising an uppermost gear, the drive gear set for engaging the cartridge assembly;
an actuator; and
a torsion spring,
wherein when the uppermost gear of the drive gear set is engaged with the toothed track of the cartridge assembly, the actuator is raised and the torsion spring is wound,
wherein after the at least one dermal perforation assembly is driven the predetermined distance, the uppermost gear of the drive gear set is seated in the toothless groove.

US Pat. No. 10,137,240

CAPILLARY CHANNEL STRUCTURE FOR DISPENSE INTERFACE

Sanofi-Aventis Deutschlan...

1. A dispense interface for a drug delivery device for delivering at least two drug agents, comprising:at least two flow regulation structures configured to connect to at least two fluid reservoirs; and
a confluence at which the at least two flow regulation structures meet,
wherein each flow regulation structure has a first end and a second end and comprises:
a fluid inlet opening at the first end, the fluid inlet opening of each flow regulation structure configured to connect to a different one of the at least two fluid reservoirs, and
a fluid outlet opening at the second end connected to the confluence,
wherein one or more of the at least two flow regulation structures each further comprises a capillary fluid channel that ends at the confluence,
each capillary fluid channel having a volume configured to contain a backflow from one or more others of the at least two flow regulation structures, and arranged in a meandering pattern on a plane perpendicular to a direction of fluid flow through an outlet of the confluence.

US Pat. No. 10,137,237

NEEDLE ARRANGEMENT

1. A needle arrangement for an injection device comprising:a needle cannula having a lumen and mounted such that a distal part having a distal tip extend in a distal direction,
a telescopically movable shield slidable between a first extended position and a second retracted position and wherein the telescopically movable shield distally carries a cleaning chamber containing a cleaning solvent for cleaning at least the tip of the needle cannula between subsequent injections and which cleaning chamber at least distally is provided with a pierceable distal septum, wherein the telescopically movable shield in the first extended position is extended to at least cover the distal tip of the needle cannula and in the second retracted position is retracted to at least expose the tip of the needle cannula,
a telescopically movable tube for guiding the needle cannula, the telescopically movable tube having a tube lumen and a distal end wherein the needle cannula is guided inside the tube lumen, and which tube lumen is movable relatively to the needle cannula, and wherein the distal end of the telescopically movable tube at least partly penetrates the distal septum when the telescopically movable shield is moved from the first extended position to the second retracted position.

US Pat. No. 10,137,231

INTRA-AORTIC BALLOON APPARATUS, ASSIST DEVICES AND METHODS FOR IMPROVING FLOW, COUNTERPULSATION AND HAEMODYNAMICS

1. A circulatory assist apparatus for use to generate pressure and create and augment flow in an aorta or other circulatory lumen, the apparatus comprising:an inflatable pumping balloon having a proximal end joined to an elongated balloon catheter, the balloon catheter having a distal end joined to the pumping balloon and a proximal end, separated from the distal end by a length sufficient to extend from within the circulatory lumen to the outside of a patient's body, for receiving positive and negative pressure pulses from a pump to inflate and deflate the pumping balloon; and
a radially and reversibly expandable frame, mounted on one of a segment extending distally from the pumping balloon, the balloon catheter, and a sleeve tube surrounding the balloon catheter;
wherein the expandable frame is manipulable to expand and collapse within the circulatory lumen, and functions to space apart the inflatable pumping balloon, when inflated, from the circulatory lumen, said expandable frame having a first diameter in a collapsed configuration for intraluminal delivery and withdrawal and a second, larger diameter in an expanded configuration achieved by said manipulation; and
wherein said expandable frame includes a radially and reversibly expandable check valve mounted on said expandable frame and configured to, upon expansion, substantially block flow away from the inflatable pumping balloon and permit flow toward the pumping balloon.

US Pat. No. 10,137,229

TREATING CONGESTIVE HEART FAILURE

Mayo Foundation for Medic...

1. A method for treating heart disease in a mammal using an assist device comprising (i) a conduit comprising a proximal region, a distal region and an intermediate region located between said proximal and distal regions, wherein said proximal region is adapted to be positioned within an aorta of said mammal, wherein said distal region is adapted to be positioned within a left atrium of said mammal, and wherein said intermediate region is adapted to define a lumen through a shared wall between said aorta and said left atrium, and (ii) a pump, wherein said pump is adapted to be positioned within said conduit,wherein said method comprises implanting said assist device with said proximal region positioned within said aorta, said distal region positioned within said left atrium, and said intermediate region positioned to extend from said aorta to said left atrium across said shared wall between said aorta and said left atrium without being positioned outside of said aorta, said left atrium, and said shared wall, wherein said shared wall extends along the ascending aorta to the aortic valve,
wherein blood flow in said mammal is enhanced, thereby treating said heart disease.

US Pat. No. 10,137,228

SYSTEM AND METHOD FOR SEALING AN INCISIONAL WOUND

KCI Licensing, Inc., San...

17. A system to treat an incisional wound having incisional walls, the system comprising:a scaffold fluidly coupled to a conduit to receive reduced pressure from a reduce pressure source, and configured to be positioned within the incisional wound adjacent the incisional walls, the scaffold being formed from an elongated porous material; and
an internal manifold having a primary flow channel extending within the scaffold and configured to be fluidly coupled to the conduit, wherein the primary flow channel is formed by an alignment of interconnected pores of the scaffold.

US Pat. No. 10,137,226

MEDICAL DRAINAGE DEVICES WITH CARBON-BASED STRUCTURES FOR INHIBITING GROWTH OF FIBROBLASTS

Mobius Therapeutics, LLC,...

1. A composition for use in manufacturing an implantable medical device, having a body with an opening therethrough defining a fluid path for passage of body fluids therethrough, the composition comprising:a carbon scaffold consisting essentially fibers combined with a biocompatible polymer; and
a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;
wherein: the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

US Pat. No. 10,137,223

ALIGNED FIBER AND METHOD OF USE THEREOF

LifeNet Health, Virginia...

1. A scaffold comprising one or more electrospun fibers comprising collagen, wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180° apart from each other.

US Pat. No. 10,137,219

COHERENT BLOOD COAGULATION STRUCTURE OF WATER-INSOLUBLE CHITOSAN AND WATER-DISPERSIBLE STARCH COATING

1. An absorbent layer comprising a non-woven fabric layer of water-insoluble chitosan fibers having a continuous coating of water-absorbent starch on at least one face of the fabric layer, wherein the starch has been modified to include hydrophilic groups into or onto molecular chains of the starch.

US Pat. No. 10,137,216

FLUID DISINFECTION DEVICE AND METHOD

Molekule Inc., San Franc...

1. A device for decontaminating a fluid, comprising: a porous filter medium having a predetermined path of fluid travel therethrough, the porous filter medium comprisinga filter, and
a fiber having a first end and a second end, wherein the first end is fixed to the filter and the second end is freely movable within the predetermined path of fluid travel, wherein the fiber is operable between a first configuration and a second configuration, wherein the fiber is opaque;at least one photocatalytic particle disposed on the fiber between the first and second ends for generating electron-hole pairs and having a cross sectional area normal to the path of fluid travel;a source of photons having a wavelength corresponding to at least a band gap energy of the at least one photocatalytic particle, and arranged to illuminate the at least one photocatalytic particle during device operation; andan agitator coupled to the porous filter medium, the agitator operable to oscillate the fiber, relative to the filter wherein the filter is fixed, between the first configuration and the second configuration during device operation, wherein the at least one photocatalytic particle is swept through an area greater than the cross sectional area in a direction normal to the path of fluid travel.

US Pat. No. 10,137,194

IMMUNOGENIC PEPTIDE CONJUGATE AND METHOD FOR INDUCING AN ANTI-INFLUENZA THERAPEUTIC ANTIBODY RESPONSE THEREWITH

The Admininstrators of th...

1. An immunogenic peptide conjugate consisting of a hemagglutinin fusion initiation region (FIR) peptide or a variant thereof, conjugated to an immunogenic carrier protein by a linking group; wherein the hemagglutinin FIR peptide consists of 16 amino acid residues and has an amino acid sequence that consists of SEQ ID NO: 1 or a variant of SEQ ID NO: 1 sharing at least 50% sequence identity therewith and differing from SEQ ID NO: 1 by one or more amino acid substitutions selected from the group consisting of V1I, V1L, V1A, V1G, V1T, V1S, V1M, E2D, E2K, E2R, D3E, T4G, T4S, T4Q, T4A, K5F, K5M, K5I, K5V, K5L, K5A, I6L, I6V, I6A, I6T, I6S, I6Q, I6N, D7E, L8I, L8V, L8A, W9Y, S10T, S10G, S10A, S10M, and E14K; wherein the immunogenic carrier protein is selected from the group consisting of the outer membrane protein complex of Neiserria meningitidis (OMPC), tetanus toxoid protein, diphtheria toxin derivative CRM197, Concholepas concholepas hemocyanin (CCH), hepatitis B virus (HBV) surface antigen protein (HBsAg), HBV core antigen protein, a rotavirus capsid protein, bovine papilloma virus (BPV) L1 protein, a human papilloma virus (HPV) L1 protein, ovalbumin, and a full-length influenza hemagglutinin protein; and wherein the linking group comprises a sulfide bond or a 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group of Formula (I):wherein a primary amine on the carrier protein is bound by an amide bond to the 1-carbonyl moiety of the 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group, and the Cys residue in Formula (I) is bound by peptide bond to the to the N-terminus of the FIR peptide, optionally with an additional spacer peptide of 1 to 5 residues between the Cys and the FIR peptide.

US Pat. No. 10,137,179

COMPOSITION AND METHOD OF PREPARATION OF PROTEASE MICROPARTICULATE SLOW RELEASE PREPARATION

HYALO TECHNOLOGIES, LLC, ...

1. A composition, comprising a plurality of biodegradable polymer microparticies comprising a protease enzyme therein, the biodegradable polymer and the protease enzyme forming a controlled release matrix for extended release of the enzyme; wherein (a) the protease is selected from the group consisting of collagenase, papain, elastase and mixtures thereof; (b) the plurality of the biodegradable polymer microparticies is a mixture of biodegradable polymer microparticles containing different proteases; (c) a first portion of the plurality of the biodegradable polymer microparticles contains collagenase, and (d) a second portion of the plurality of the biodegradable polymer microparticles contains papain or elastase.

US Pat. No. 10,137,138

SULFONYLUREA DERIVATIVES OF OLEANOLIC ACID

King Saud University, Ri...

1. A sulfonylurea derivative of oleanolic acid, comprising a compound having the formula:where R is selected from the group consisting H and CH3, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,137,134

MOLYBDENUM COMPOUNDS FOR USE IN THE TREATMENT OF CYANIDE POISONING

1. A compound according to the following formula:
Wherein
X is S or a bond; and
R1, R2, and R3 independently or together are one or more of the ligands selected from: a mono- or disaccharide having 3 to 12 carbon atoms, a mono- or di-carboxylic acid having 1 to 5 carbon atoms, which may be substituted with O, S, CH3S— or N, a thiocarboxylic acid having 1 to 5 carbon atoms, a primary, secondary or tertiary amide having 1 to 5 carbon atoms, wherein the side chains attached to the nitrogen is an alkyl having 1 to 5 carbon atoms, threonine, serine, glutamate, malate, oxalate, mercapto succinate, cyanide thiocyanate, thiosulfate, or sulfite; and wherein R3 may be an electron pair.

US Pat. No. 10,137,116

BENZIMIDAZOLE SULFIDE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF TUBERCULOSIS

1. A method of treating tuberculosis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a benzimidazole sulfide derivative of general formula (I):wherein R is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-heteroalkyl, C1-C6-haloalkyl, aryl, C1-C6-alkyl aryl, heteroaryl, C1-C6-alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6-alkenyl heteroaryl, C3-C8-cycloalkyl, C1-C6-alkyl cycloalkyl, heterocycloalkyl, C1-C6-alkyl heterocycloalkyl, carboxy, C1-C6-alkyl carboxy, acyl, C1-C6-alkyl acyl, acyloxy, C1-C6-alkyl acyloxy, alkoxy, C1-C6-alkoxy, C1-C6-heteroalkoxy, C1-C6-haloalkoxy, C1-C6-alkoxycarbonyl, halogen, sulfanyl, and C1-C6-alkylsulfanyl, a pharmaceutically acceptable salt thereof, and/or a mixture thereof.

US Pat. No. 10,137,109

CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS

INCURON, INC., Buffalo, ...

1. A method for treating melanoma, comprising intraarterially administering to a patient in need thereof an effective amount of a compound of a structural formula:
wherein Ra is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe; alternatively, either Ra and R1 or NRe and R1 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rb is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe, alternatively, either Rb and R6 or NRe and R6 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic ring or a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rc is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rc and Rd are taken together to form a five, six, or seven-membered aliphatic ring, optionally containing an oxygen atom;
Rd is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rd and R7 together with the atoms to which they are attached form a five or six-membered aliphatic ring;
Re, independently, is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or two Re groups taken together with a nitrogen to which they are attached to form a five or six-membered aliphatic ring;
R1, R2, R3, R4, R5, and R6, independently, are selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, ORe, C(?O)Re, C(?O)ORe, OC(?O)Re, C(?O)N(Re)2, C(?O)NReSO2Re, N(Re)2, NReC(?O)Re, NReC(?O)N(Re)2, CN, NO2, CF3, OCF3, SRe, SORe, SO2N(Re)2, and OSO2CF3;
R7 is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and
n is 1, 2, 3, 4, or 5,
or a pharmaceutically acceptable salt or hydrate thereof and
wherein the intraarterial administration is intraarterial infusion.

US Pat. No. 10,137,103

COMPOSITIONS AND METHODS FOR THE TREATMENT OF FATTY ACID METABOLISM DISORDERS

1. A method for treating a fatty acid oxidation disorder in a subject, said method comprising administering at least one S-nitrosylating agent to said subject,wherein said S-nitrosylating agent is a mononitrated-diheptanoin.

US Pat. No. 10,137,093

MILRINONE CONTROLLED-RELEASE FORMULATION

Cardiora Pty Ltd., Melbo...

1. An oral controlled-release formulation comprising:(i) a core comprising:
(a) milrinone, or a pharmaceutically acceptable salt thereof;
(b) hydroxypropylmethylcellulose having a viscosity of 80,000 to 120,000 cps:
hydroxypropylmethylcellulose having a viscosity of about 50 cps;
and at least one pharmaceutically acceptable excipient;
and
(ii) a sustained release coating; and
(iii) an enteric coating; wherein the formulation permits the release of milrinone, or a pharmaceutically acceptable salt thereof, into the bloodstream in an amount that is effective to ameliorate symptoms of heart failure for a period of at least 6 hours,
wherein the hydroxypropylmethylcellulose (80,000 to 120,000 cps) and the hydroxypropylmethylcellulose (about 50 cps) are in a ratio of about 1.5:1 to 1:1.5, and the ratio of milrinone, or a pharmaceutically acceptable salt thereof, to total hydroxypropylmethylcellulose is about 1:3 to 1:5, and
wherein the formulation exhibits zero order release of about 100% of milrinone, or a pharmaceutically acceptable salt thereof, over about 12 hours at pH 6.8.

US Pat. No. 10,137,092

DOUBLE-LAYER TABLET AND PREPARATION METHOD THEREOF

1. A method of preparing a double-layer tablet comprising an upper layer on top of a lower layer, comprising:1) pressing a first active ingredient and a first pharmaceutically acceptable excipient to form the upper layer, wherein the upper layer is a sustained-release layer and comprises one or more holes, and the diameter of each hole is between about 2 mm and about 6 mm; and
2) pressing the upper layer onto a second active ingredient and a second pharmaceutically acceptable excipient, which are configured to form the lower layer, to form the double-layer tablet comprising the upper layer on top of the lower layer,
thereby part of the second active ingredient and the second pharmaceutically acceptable excipient of the lower layer are filled into the hole(s) of the upper layer.

US Pat. No. 10,137,089

SOLVENT EXTRACTION FROM BIODEGRADABLE MICROPARTICLES

Rezolute, Inc, Louisvill...

1. A system for reducing a solvent concentration in a plurality of microparticles, the system comprising:an emulsifier that mixes an oil phase from an oil phase mix tank and a water phase from a water phase mix tank;
a first solvent extraction tank in fluid communication with the emulsifier;
a concentration unit in fluid communication with the first solvent extraction tank, the concentration unit comprising a cross-flow filtration column in fluid communication with a second solvent extraction tank;
a washing unit adapted to receive a microparticle concentrate from the concentration unit; and
a water tank separate from the water phase mix tank;
wherein:
the water tank is in fluid communication with the concentration unit without passing through the emulsifier, the first solvent extraction tank, or the washing unit,
the water tank is in fluid communication with the first solvent extraction tank without passing through the emulsifier, the concentration unit, or the washing unit,
the first solvent extraction tank comprises a mixer to keep the microparticles from settling to the bottom of the first solvent extraction tank,
the cross-flow filtration column is operable to remove water and a solvent from the second solvent extraction tank without removing the microparticles, and
the cross-flow filtration column comprises a ceramic membrane.

US Pat. No. 10,137,060

INFANT PACIFIER WITH IMPROVED RETENTION

1. A pacifier, comprising:a nipple portion comprising a bulb and a stem, the bulb extending proximally from the stem;
a shield, the nipple portion extending proximally from the shield, the shield extending radially outwardly about the circumference of the stem and having an outer edge comprising top, side and bottom edge portions, the entire shield outer edge being distal of the bulb;
a retainer portion spaced from the nipple portion, the retainer portion extending proximally and terminating at a contact pad; and
an extension extending between the nipple portion and the retainer portion, at least part of the extension being distal of the nipple portion and attached to the shield, the extension depending below the bottom edge portion of the shield, the extension supporting the retainer portion so as to maintain the retainer portion at a position wherein the retainer portion extends proximally, generally parallel to and spaced from the stem;
wherein the retainer portion is biased toward the nipple portion; and
wherein no portion of the pacifier proximal of the shield extends higher than the top edge portion of the shield when the pacifier is held so that the stem extends horizontally with the top edge portion of the shield higher than the stem.

US Pat. No. 10,137,059

NURSING BOTTLE WITH INTEGRATED COLLAR AND NIPPLE FLANGE VENTING STRUCTURE

3. A single vented container for use for holding a liquid, and for dispensing of the same, said container consisting of a body portion, a neck portion, the neck portion having integral threads, a collar provided for the container, and having internal threads capable of engagement with the neck portion of said container, a nipple provided upon the upper neck portion of the bottle, said nipple having an upstanding dispensing portion, and an integral flange extending radially from the bottom of the nipple, said flange having a vertical aperture extending therethrough, communicating with the interior of the bottle, and said flange having an upper surface, and a flange passage provided upon the upper surface of the flange nipple, communicating with the flange vertical aperture, and extending radially to the perimeter edge of the nipple flange, and communicating with the space between the threads securing the collar to the neck of the bottle, said nipple flange having a lower surface, an integral sleeve provided upon the lower surface of the nipple flange, and said sleeve being in alignment with the vertical aperture through said flange, a vent tube securing with the integral sleeve upon the lower surface of said nipple flange, and said vent tube provided for securing with said integral sleeve for holding the vent tube into position when applied for venting with the single vented container during usage, wherein said container comprises a nursing bottle, and wherein said nipple is a nursing bottle nipple.

US Pat. No. 10,137,056

DEVICE FOR SEXUAL STIMULATION

1. A device for sexual stimulation of a human body, said device comprising a phallus-shaped stimulation body having a thickness and/or a length that is variable in regions, wherein the stimulation body comprises a length adjustment element that is movable to lengthen and shorten the stimulation body in an axial direction in relation to a main body of the stimulation body, and has a hollow cylinder that is mounted on and displaceable on the main body, wherein the stimulation body is provided with permanent magnets to vary the length of the stimulation body, the permanent magnets being arrangeable in a starting position, in which the permanent magnets mutually attract, and in a lengthening position, in which the permanent magnets mutually repel, and the length adjustment element is movable on the main body by movement of the permanent magnets between the starting position and the lengthening position.

US Pat. No. 10,137,055

PORTABLE FITNESS ROLLER

1. A portable fitness roller comprising:an outer contact skin having an outer compressible surface configured for use as a fitness roller, wherein the outer contact skin includes a series of rigid axial stiffeners running parallel to a central roller axis and extending a length of the outer contact skin, adjacent axial stiffeners being joined together via joints parallel to the central roller axis so that the axial stiffeners and outer contact skin can be formed into a tubular expanded shape defining a cylindrical volume and the axial stiffeners may be released from the tubular expanded shape so as to convert to a collapsed shape, the fitness roller in the expanded shape having sufficient strength to support the weight of a person rolling thereon without collapse; and
a plurality of stiffening elements disposed within the outer contact skin so as to contact and radially support the outer contact skin in the tubular expanded shape and that are movable relative to each other to permit the outer contact skin to assume the collapsed shape by manually displacing two of the plurality of stiffening elements located at each longitudinal end of the support structure.

US Pat. No. 10,137,054

MASSAGE DEVICE EQUIPPED WITH INTERCHANGEABLE MASSAGE HEADS

SEB S.A., Ecully (FR)

1. Massage device (1) including:a body (2) which contains a drive mechanism (3),
at least one type of massage head (4, 5, 6, 7 and 8) which includes massage elements,
a transmission mechanism which allows the massage elements to be activated by the drive mechanism,
an installation mechanism (9) which is configured for the installation and removal of the at least one type of massage head with the body, characterized in that the device includes recognition means (146) of the type of massage head installed on the body and control mechanisms (161) for controlling said massage device based on the recognition of the type of massage head, wherein the massage device comprises a reduction gear installed on an output of a motor,
wherein the installation mechanism comprises a snapping mechanism comprising a blockage system with a notch and a release latch,
wherein the recognition means comprises: (i) mechanical sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body; or (ii) magnetic sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body, and
wherein the mechanical or magnetic sensors are formed in grooves of the body that receive protuberances of the at least one type of massage head such that the protuberances trigger the mechanical or magnetic sensors and are recognized based on binary code programmed into a command box.

US Pat. No. 10,137,053

MASSAGE APPARATUS

DAITO ELECTRIC MACHINE IN...

1. A massage apparatus comprising:a backrest for supporting user's back; and
a massager disposed inside the backrest for producing massage action on the user's back,
said backrest having its front side with a two-layer structure, and being provided with a warm-cool air supply section capable of feeding warm air or cool air into an interlayer region of said two-layer structure,
said massager being configured to move up and down along a direction of length of said backrest,
said warm-cool air supply section being located outside of a movement area of the massager,
said movement area of said massager having a shape of an elongated strip that extends in the length direction,
said warm-cool air supply section being disposed on at least a right side or a left side of said movement area,
said two-layer structure comprising a front cover body constituting a front face of said backrest and a back cover body disposed in a state of overlying a back side of the front cover body,
the interlayer region is configured to store warm air or cool air created between said front cover body and said back cover body,
said warm-cool air supply section being connected to the interlayer region and is configured to feed warm air or cool air into said interlayer region,
said warm-cool air supply section including a blower fan, a fan motor, and a heater, the blower fan delivering air to the heater to produce heated air and to feed the heated air into the interlayer region of the two-layer structure, and
when viewed from a lateral direction, the warm-cool air supply section, including the blower fan, the fan motor, and the heater, is located in overlapping relation with the movement area of the massager,
wherein the massage apparatus further comprises a cover plate being plate shaped and overlying a front face of the massager, the cover plate being provided with an opening at a location corresponding to the movement area of the massager,
wherein the warm-cool air supply section includes right and left warm-cool air supply sections being disposed on at least either of a right side and a left side of the opening on a rear face of the cover plate in a horizontal direction, with said opening lying in between the right and left warm-cool air supply sections,
wherein the back cover body is attached to the opening of said cover plate,
wherein the front cover body overlies the cover plate to cover an entire front side of the cover plate,
wherein the right and left warm-cool air supply sections are configured to feed warm air or cool air from a respective open hole of the cover plate, and
wherein the open holes of the right and left warm-cool air supply sections are located at a lower end side of the cover plate.

US Pat. No. 10,137,051

SINGLE TUBE CRUTCH AND METHOD OF NESTING AND PACKAGING THE SAME

Medline Industries, Inc.,...

1. A crutch, comprising:a single tube support comprising an upper leg and a lower leg comprising a slip-resistant tip, the lower leg fully insertable into a first end of the upper leg such that only the slip-resistant tip is exposed;
an underarm support coupled to a second end of the upper leg opposite the first end;
a grip assembly configured to translate along the upper leg between a usage position and a stowed position, the grip assembly comprising an annular receiver and a grip extending distally from the annular receiver;
a plurality of grip assembly apertures disposed along the upper leg, each of which the grip assembly may align when in the usage position; and
a stowage aperture disposed along the upper leg, with which the grip assembly may align when in the stowed position.

US Pat. No. 10,137,047

AUTOMATED PILOTLESS AIR AMBULANCE

1. An automated pilotless air ambulance system comprising:an air vehicle (AV) having a fuselage, the fuselage having a stretcher mounted thereon for carrying a patient, the air vehicle configured to be dispatched to a point of injury of the patient and further configured to transport the patient to a medical treatment facility;
a plurality of air-lift motors coupled to the fuselage for vertically lifting the air vehicle, each air lift motor being coupled to a mounting arm such that the air lift motors are disposed substantially in the front and back of the fuselage, thereby enabling the stretcher to be transported with the patient thereon into and out of the AV, and wherein each mounting arm is securely coupled to the fuselage to form a low-profile configuration, whereby the patient is nested in the AV such that each air lift motor is disposed substantially on the same plane as the patient;
an automated life support and monitoring patient suite having a plurality of life support and monitoring devices and medical supplies; and
a bidirectional datalink coupled to the air vehicle, the datalink configured to execute the following functions:
receive and send signals to a patient's or first responder's mobile device or a networked device having geolocation capabilities, thereby enabling the air vehicle to obtain a geographic earth location of the patient;
receive and send signals to the patient's or first responder's mobile device for allowing the air vehicle to be autonomously dispatched when contacted by the patient's or the first responder's mobile device or the networked device;
receive and send signals to at least one medical health provider or physician who is using another air vehicle (AV) system to provide guidance to the first responder; and
receive and send signals to the at least one medical health provider or physician in order to allow the at least one medical health provider or physician to monitor the patient's vitals and to prepare the medical treatment facility for the patient's arrival.

US Pat. No. 10,137,046

DISPOSABLE BEDPAN WITH LID

1. A disposable bedpan with lid, comprising:A) a bedpan comprising a base and a sidewall having at least one lateral support, said bedpan further comprises a top ridge and a front ridge, said bedpan further comprises a front top cavity defined between said top ridge and said front ridge;
B) a cover comprising a cover base and a u-shaped cover base ridge, said u-shaped cover base ridge is inserted into said front top cavity when said cover mounts upon said bedpan, said cover is connected to said bedpan by a hinge; and
C) a lid comprising a lid panel, said lid is connected to said bedpan by a lid hinge, said lid further comprises at least one panel locking protrusion that secures upon said cover when in a closed configuration, said cover and said lid seal said bedpan to prevent waste from coming out when in said closed configuration, said lid panel comprising at least one lid ridge.

US Pat. No. 10,137,044

PATIENT SUPPORT APPARATUS WITH SENSOR ASSEMBLY

Hill-Rom Services, Inc., ...

1. A patient support system, comprising:a patient support device including an air fluidizable section, the air fluidizable section including a basin containing fluidization material for creating a two-phase support surface for patient support by distribution of pressurized fluid through the fluidization material, and
a sensor assembly configured to detect a temperature within the air fluidizable section, the sensor assembly comprising:
a housing defining an interior space, the housing being coupled to a wall of the air fluidizable section,
a processor, the processor being positioned within the interior space of the housing,
a thermal conductor, and
a thermal insulator.

US Pat. No. 10,137,040

ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. An absorbent article having a wearer-facing side and a garment-facing side, and extending in a longitudinal direction and a transversal direction, the article comprising:a topsheet on the wearer-facing side for contact with a wearer's skin;
a backsheet on the garment-facing side;
an absorbent core between the topsheet and the backsheet, wherein the absorbent core comprises an absorbent material layer, the absorbent material layer comprising an absorbent material and further comprising a longitudinally-extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;
wherein the absorbent core further comprises a first folding guide dividing the central portion and the first side portion, and a second folding guide dividing the central portion and the second side portion;
wherein the central portion and the side portions form a three-dimensional basin when the absorbent core is folded along the folding guides;
wherein the absorbent article further comprises:
at least one liquid management layer substantially free of superabsorbent polymer, the liquid management layer being at least partially disposed between the topsheet and the absorbent core; and wherein the liquid management layer comprises a liquid management layer's central portion, a first and second liquid management layer's side portions, and a first and second liquid management layer's folding guides between the liquid management layer's central portion and the first and second liquid management layer's side portions respectively, wherein the liquid management layer's folding guides are at least partially superposed with the folding guides of the absorbent core; and wherein each side portion comprises a plurality of winglets arranged in the longitudinal direction, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, wherein neighboring winglets are separated by a gap between their neighboring sides.

US Pat. No. 10,137,039

ABSORBENT CORES HAVING CHANNEL-FORMING AREAS AND C-WRAP SEALS

1. A absorbent core extending in a transversal direction and a longitudinal direction, the absorbent core having a front edge, a back edge and two longitudinally extending side edges, the absorbent core comprising:(a) a core wrap comprising a first substrate and a second substrate wherein each substrate comprises an inner surface and an outer surface;
(b) an absorbent material comprising a periphery defining an absorbent material deposition area, between the first substrate and the second substrate, the absorbent material deposition area encompassing one or more areas substantially free of absorbent material; and
(c) an auxiliary glue applied directly to the inner surface of the first substrate and defining an auxiliary glue application area;
wherein the auxiliary glue at least partially bonds the inner surface of the first substrate to the inner surface of the second substrate through the one or more areas substantially free of absorbent material, so that when the absorbent material swells, the core wrap forms channels in the areas substantially free of absorbent material that have a width from 2 mm to 20 mm;
wherein the auxiliary glue application area is smaller than the absorbent material deposition area and the first substrate and/or the second substrate comprises at least one outwardly extending flap which is folded around at least one of the front, back, or any of the side edges of the core, and the at least one flap is bonded to the external surface of the other substrate to form a C-wrap seal along the at least one edge of the absorbent core; and
wherein the channels do not extend to any edge of the absorbent material deposition area.

US Pat. No. 10,137,038

STERILE ADHESIVE BANDAGE CONTAINING A POCKET

1. An adhesive bandage comprising a base portion having at least one gauze portion adapted to contact a wound in a skin surface and an adhesive portion; the adhesive portion having an adhesive on a first surface of the base portion adapted to adhere to skin around three sides of and peripheral to the wound; the base portion defining a pocket adapted for storing the at least one gauze portion, wherein the pocket comprises a folded over flap of the base portion and a side opening of the pocket allowing inspection and replacement of the at least one gauze portion without having to remove the entire bandage.

US Pat. No. 10,137,036

UNDERWATER MASK

TABATA CO., LTD., Tokyo ...

1. An underwater mask having an up-down direction and a lateral direction, comprising: a mask body having opposing sides and which comprises a lens frame having a lens on a front; a skirt extending rearward from the lens frame; and a strap configured to be coupled to at least one of the opposing sides of the mask body through a buckle, the strap having a plurality of engaging teeth, the buckle comprising: a base; a strap adjuster body; a handling member; and a stopper, the base comprising: a second coupling portion configured to be coupled to a first coupling portion on the at least one of the opposing sides turnably in the lateral direction; a fitting hole; and a spring comprising a locking hook, the strap adjuster body comprising: a plurality of engaging teeth opposite the spring configured to sequentially engage with the locking hook; a fitting shaft configured to be fitted into the fitting hole turnably by a predetermined angle in a circumferential direction of the fitting shaft; a guide shaft configured to be wound by the strap; a slide guide groove extending in the up-down direction; and a pair of guide openings opposite to each other in the up-down direction, the handling member comprising: an approximately V-shaped spring; a slider configured to slide along the slide guide groove; a pair of sliding portions near the slider; and a finger pad outside each sliding portion of the pair of sliding-portions, the finger pads configured to be exposed from the guide openings of the strap adjuster body, the stopper comprising: a pawl configured to sequentially engage with the engaging teeth of the strap; and a sliding contact tapered protrusion near the pawl, the sliding contact tapered protrusion slidably disposed between the pair of sliding portions, wherein the stopper is configured to be held by the strap adjuster body swingably toward a direction opposite to the body.

US Pat. No. 10,137,034

PRESSURE-SENSING VITRECTOMY SURGICAL SYSTEMS AND METHODS

Novartis AG, Basel (CH)

1. A system for providing irrigation into an eye of a patient during a medical procedure, the system comprising:an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including:
a flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient;
an engagement member at the distal end, the engagement member being more rigid than the flexible elongate member and being configured to enter into a vitreous chamber of the eye of the patient; and
at least three pressure sensors internally disposed in the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential associated with a flow impediment along the infusion line between two of the at least three pressure sensors, such that the flow impediment is locatable between the two pressure sensors associated with the flow impediment pressure differential.

US Pat. No. 10,137,032

SLUSH GENERATION

42 TECHNOLOGY LIMITED, C...

1. An apparatus for generating, at a target ice/liquid ratio with a corresponding target temperature, a slush comprising a frozen and non-frozen liquid, the apparatus comprising:a flow path that recirculates the frozen and non-frozen liquid therethrough; and
a heat exchanger, forming part of the flow path, comprising a coolant conduit extending longitudinally through the heat exchanger and a freeze conduit extending longitudinally through the heat exchanger, wherein the coolant conduit and the freeze conduit share a contiguous boundary along their longitudinal length through the heat exchanger such that thermal energy is transferred between the freeze conduit and the coolant conduit to partially freeze the non-frozen liquid in the conduit loop to generate the slush at the target ice/liquid ratio;
wherein the freeze conduit is devoid of an ice scraper and the coolant conduit is configured for flow therethrough of coolant at a temperature below the target temperature, the apparatus being configured to vary the rate of coolant flow through the coolant conduit between a first rate and a second rate that is lower than the first rate.

US Pat. No. 10,137,030

SELF-TITRATABLE MANDIBULAR REPOSITIONING DEVICE

Sleep Science Partners, I...

1. A mandibular re-positioning device, comprising:a first component adapted to receive a user's top teeth and a second component adapted to receive the user's bottom teeth and an intermediate component adapted to fit between the upper component and the lower component and to couple the upper and lower components;
a first mechanism coupling together the upper component with the intermediate component;
the first mechanism coupling the upper and intermediate components in either of two states comprising an unlocked state or a locked state;
the unlocked state allowing the upper and intermediate components to slide, relative to each other, along a sagittal axis, thereby allowing the user's mandible to freely move in an anterior or posterior direction while the mandibular re-positioning device is positioned within the user's mouth;
the locked state bringing the first component into closer contact with the intermediate component, thereby preventing the two components from sliding, relative to each other, along the sagittal axis, thereby preventing any change in mandibular advancement while the mandibular re-positioning device is positioned within the user's mouth;
the first mechanism being able to transition from the unlocked state to the locked state through application of a force along a vertical axis, the force coming from the user biting down;
a second mechanism coupling together the intermediate component with the second component and adapted to allow movement of the user's mandible in a lateral direction while the mandibular re-positioning device is positioned within the user's mouth; and
the second mechanism including a groove along the lateral direction within the second component, the groove coupling to a rail or to a tab on the intermediate component that travels within the groove, the groove being curved within the second component to match a natural movement of the user's mandible.

US Pat. No. 10,137,028

EYEWEAR SYSTEM FOR SECURING LENS ON A USER'S NOSE AND DILATING USER'S NOSE

1. A device for coupling at least one eyewear lens to at least one nasal applique attachable to a user's nose which results in dilation of a nasal passageway, the device comprising:a base engageable with the at least one eyewear lens;
an adjustment shaft coupled to the base and extending longitudinally along a rotation axis, the adjustment shaft being rotatable relative to the base about the rotation axis;
a first pivot unit coupled to the base and pivotable relative to the base about a first pivot axis in response to rotation of the adjustment shaft about the rotation axis; and
a second pivot unit coupled to the base and pivotable relative to the base about a second pivot axis in response to rotation of the adjustment shaft about the rotation axis;
the first pivot unit and the second pivot unit being interactable with at least one nasal applique to magnetically couple the first pivot unit and the second pivot unit to the at least one nasal applique, the magnetic coupling between the first pivot unit and the second pivot unit and the at least one nasal applique imparting a dilating force on the user's nose to dilate the nasal passageway when the at least one nasal applique is attached to the user's nose.

US Pat. No. 10,137,027

NASAL APPLIQUE AND RELATED APPLICATOR FOR APPLYING APPLIQUE TO A NOSE OF A WEARER

1. An applicator for placing a pair of nasal appliques on opposing lateral regions of a nose of a user, the applicator comprising:a base;
a nose rest coupled to the base and adapted to rest adjacent the nose of the user;
a pair of stop members coupled to the base and arranged in generally opposed relation to each other; and
a pair of placement members coupled to the base, each placement member including an arm coupled to the base and a pad coupled to the arm, each placement member being engageable with a respective one of the pair of nasal appliques, each placement member being selectively transitional between a first position and a second position, when each placement member is in its first position, the placement member is positioned adjacent the respective one of the pair of stop members and when each placement member is in its second position, the placement member is moved away from the respective one of the pair of stop members for placing the respective one of the pair of nasal appliques on the nose of the user.

US Pat. No. 10,137,025

DEVICE AND METHOD FOR ELECTRIC STIMULATION OF MUSCLES INVOLVED IN HUMAN PHYSIOLOGICAL GAIT PATTERN AND BRACE TO SUPPORT AN ANATOMICAL JOINT WITH SUCH DEVICE

EVOMOTION GMBH, Luenebur...

5. A device for electrical stimulation of muscles involved in the physiological gait of a human, comprising: an element for electrical muscle stimulation; a sensor to detect information relevant to the muscle stimulation, wherein the sensor comprises a single gyroscope constructed to detect information including an angular speed ? and a swing direction in an extension direction and flexion direction of an anatomical lower leg of the human; an evaluation unit including a microprocessor to evaluate the information detected by the gyroscope and to determine a defined switching time for the muscle stimulation on the basis of the angular speed ? and the swing direction, and to transmit the determined switching time; and a control and regulation unit to trigger muscle stimulation by said element in response to receipt of the determined switching time.

US Pat. No. 10,137,024

APPARATUS, SYSTEM, AND METHOD FOR CONTROLLING MOVEMENT OF AN ORTHOPEDIC JOINT PROSTHESIS IN A MAMMALIAN SUBJECT

Elwha LLC, Bellevue, WA ...

1. A method for preventing dislocation of an orthopedic joint prosthesis in a mammalian subject comprising:providing an orthopedic brace external to the subject's body and including a first member and a second member, wherein the first member is configured to control movement of a first component of an internal orthopedic joint prosthesis and the second member is configured to control movement of a second component of the internal orthopedic joint prosthesis in the subject;
detecting one or more alignment orientations of the first component relative to the second component by one or more sensors in proximity to the first component and the second component of the internal orthopedic joint prosthesis, wherein the one or more sensors contact the internal orthopedic joint prosthesis;
communicating the one or more alignment orientations from the one or more sensors to one or more controllers; and
adjusting an alignment of the first component relative to the second component of the internal orthopedic joint prosthesis in response to a signal from the one or more controllers in operation with the first member and the second member of the orthopedic brace external to the subject's body.

US Pat. No. 10,137,019

MEDICAL INSTRUMENT, RING PROSTHESIS, STENT AND STENTED VALVE

DAIDALOS SOLUTIONS B.V., ...

1. A stent, comprising:a tubular element with an open grid structure which is radially expandable from a compressed condition to an expanded condition, and which has a proximal and distal end; and
a ring structure provided around the tubular element,
wherein the tubular element and ring structure are interconnected,
wherein the ring structure is a variable-diameter ring structure with distal and proximal flange feet,
wherein the ring structure has an axial direction and a radial direction disposed transverse to the axial direction,
wherein the ring structure is constructed from a series of elongated closed loops lying next to one another which, in each case, at the midpoint of the longitudinal sides of the loops, are attached laterally to one another via a junction to form the ring structure, in such a way that a) an imaginary center line through all junctions forms a closed ring and divides each loop into a distal flange foot of said distal flange feet and a proximal flange foot of said proximal flange feet, and b) the ring structure is expandable,
wherein the distal and proximal flange feet each have a fixed end arranged at the imaginary center line and a free end pointing away from the imaginary center line,
wherein the distal and proximal flange feet have a radial position, in which the free ends of the flange feet point in the radial direction,
wherein the distal and proximal flange feet have an extended position, in which the distal and proximal flange feet extend in the axial direction,
wherein the distal flange feet and the proximal flange feet lie in a longitudinal direction of the tubular element when the tubular element is in the compressed condition and the distal and proximal flange feet are in the extended position,
wherein the distal and proximal flange feet, when in the extended position, are under a pre-tension, which, upon release, bends the distal and proximal flange feet from the extended position to the radial position,
wherein, in the extended position, the free ends of the distal flange feet point in the distal direction whilst the free ends of the proximal flange feet point in the proximal direction such that, after the distal and proximal flange feet have bent from the extended position to the radial position, the distal and proximal flange feet interact to clamp surrounding tissue between the distal and proximal flange feet, and
wherein the distal flange feet, at the fixed ends of the distal flange feet, have a concave-curved part including a hollow side facing toward the proximal flange feet, and in the hollow side of the concave-curved part, a filling is provided that is configured to increase a clamping force with which the distal and proximal flange feet clamp the tissue in situ when the distal and proximal flange feet are in the radial position.

US Pat. No. 10,137,018

ENDOVASCULAR ROUTER DEVICE AND METHOD

1. A router device for repairing a tubular vessel of a patient, where the tubular vessel is joined to at least one branch vessel, the router device comprising:a) a single wall and skeleton-free tubular graft having a proximal end and a distal end and at least one unobstructed fenestration formed therein before deployment in the patient, said fenestration adapted to receive and affix a stent, and a malleable annulus formed in a side of said tubular graft wherein the inner diameter of the annulus defines the fenestration and where the annulus inner diameter when deformed has a portion adjacent to the stent with a greater width than the outer diameter of the annulus and said fenestration sized and positioned to generally align with the branch vessel;
b) said distal end of the tubular graft having a diameter less than a diameter of the proximal end, and said single wall of the tubular graft including a tapered portion between the proximal and distal ends, wherein said fenestration is positioned within the tapered portion;
c) a cylindrical element including an outer surface that is adapted to be juxtaposed circumferentially to an interior surface of the tubular vessel so as to releasably affix the proximal end of the tubular graft to an interior surface of the tubular vessel so that the tubular graft may be repositioned within the tubular vessel of the patient; and
d) said distal end of the tubular graft configured so as to be suspended within an aneurysm formed in the tubular vessel when the proximal end of the tubular graft is affixed to the interior surface of the tubular vessel by the cylindrical element.

US Pat. No. 10,137,011

POWERED ANKLE-FOOT PROSTHESIS

Massachusetts Institute o...

1. An autonomous, wearable powered leg device, comprising:a) a controllable powered actuator including a motor being linkable to an ankle joint to thereby impart torque about the ankle joint;
b) a controller that includes an electromyographic processing unit linked to the controllable powered actuator;
c) at least one electromyographic sensor coupled to the electromyographic processing unit and connectable to limb muscles of an individual wearing the device, whereby electromyographic signals measured from the limb muscles are transmitted to the electromyographic processing unit and thereby modulate control commands from the controller; and
d) a plurality of servo controllers, at least one of the servo controllers linking the electromyographic processing unit to the controllable powered actuator, whereby the individual wearing the device can modulate the controller to adjust between the plurality of the servo controllers, wherein the servo controllers include:
i) a torque controller that provides an offset torque during powered plantar flexion push-off of the powered leg device;
ii) an impedance controller that modulates at least one of joint stiffness and damping of the powered leg device during a stance phase of a gait of the individual; and
iii) a position controller that controls foot position of the powered leg device during a swing phase of the gait of the individual.

US Pat. No. 10,137,010

COORDINATING OPERATION OF MULTIPLE LOWER LIMB DEVICES

VANDERBILT UNIVERSITY, N...

1. A method for operating an autonomous powered leg prosthesis for a lower limb of a body having at least one powered joint, at least one sensor for collecting real-time sensor information for the autonomous powered leg prosthesis, and a communications device, the method comprising:generating, via a first control system of the autonomous leg prosthesis, first control data for the communications device to establish a communications link with a second leg prosthesis associated with another lower limb of the body contralateral to the lower limb and having a second control system operating independently of the first control system;
receiving, at the first control system over the communications link, remote data for the second leg prosthesis, the remote data comprising state information for a second finite state model used by the second control system for operating the second leg prosthesis;
generating, via the first control system, second control data for transitioning the autonomous leg prosthesis from a current state in a first finite state model for operating the autonomous powered leg prosthesis to a different state in the first finite state model,
wherein the different state is selected based on the real-time sensor information and the remote data, wherein at least one state in the first finite state model is configured for causing the at least one powered joint to deliver net power, wherein the second control data further comprises instructions to transition the autonomous leg prosthesis to the at least one state only if the state data in the remote data indicates that the second leg prosthesis is in a weight bearing state.

US Pat. No. 10,137,007

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion;
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion; and
at least one spike pivotally attached to at least one of the first and second spaced apart walls of the yoke;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke;
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position; and
wherein the linear motion of the yoke is translated to pivotal motion of the at least one spike from a collapsed position, to a fully deployed position transverse to the mid-longitudinal axis.

US Pat. No. 10,137,006

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween, the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion; and
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke; and
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position.

US Pat. No. 10,137,005

DEVICE AND METHOD FOR DEPLOYMENT OF AN ANCHORING DEVICE FOR INTERVERTEBRAL SPINAL FUSION

Globus Medical, Inc., Au...

1. An intervertebral fusion device comprising:a spacer adapted to be implanted between an upper vertebral body and a lower vertebral body;
a first anchor and a second anchor positioned within the spacer; and
an actuation screw positioned within the spacer and adapted to engage with the first anchor and the second anchor,
wherein when the actuation screw is actuated in a first direction, the first anchor moves to engage the upper vertebral body and the second anchor moves to engage the lower vertebral body, wherein the first anchor and the second anchor are configured to be moved simultaneously, and
wherein each of the first and second anchors includes a first side and a second side opposite the first side, the second side including a plurality of linear cuts configured to engage with the actuation screw.

US Pat. No. 10,137,003

LOW PROFILE INTERVERTEBRAL IMPLANT

DePuy Synthes Products, I...

1. A low profile intervertebral implant sized and configured to be implanted between adjacent upper and lower vertebral bodies, the implant comprising:a spacer having a first insertion end, a second end opposite the first insertion end, an upper surface configured to contact the upper vertebral body when the implant is implanted, and a lower surface configured to contact the lower vertebral body when the implant is implanted;
a plate including a first surface and a second surface opposite the first surface, the second surface spaced from the first surface in a first direction, the plate configured to be coupled to the spacer such that the second surface of the plate faces the second end of the spacer, the plate including an upper plate surface configured to face the upper vertebral body when the implant is implanted, the plate including a lower plate surface configured to face the lower vertebral body when the implant is implanted, the plate defining a first through hole configured to receive a first bone screw, the plate further including a first arm that extends from the second surface in the first direction, the first arm including a first inner spacer contacting surface, the plate further including a second arm that extends from the second surface in the first direction, the second arm including a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a second direction that is perpendicular to the first direction; and
a bone fixation element that extends away from the upper plate surface at a location spaced from the first surface in the first direction, the location spaced from the second surface in a direction opposite the first direction;
wherein the second surface, the first inner spacer contacting surface, and the second inner spacer contacting surface combine to define a void that is configured to receive a portion of the spacer, the void defining a first width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a first position, the void defining a second width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a second position, the first width is greater than the second width, and the second width is spaced from the first width in the first direction.

US Pat. No. 10,137,002

STANDALONE INTERBODY IMPLANTS

Globus Medical, Inc., Au...

1. An intervertebral implant for implantation in an intervertebral space between adjacent vertebrae, the implant comprising:a spacer having a superior surface, an inferior surface, a proximal end, and a distal end, wherein the superior surface and the inferior surface each have a contact area configured to engage adjacent vertebrae, the spacer defining an opening extending from the superior surface to the inferior surface of the spacer, and the spacer defining a cutout extending from the proximal end to the opening;
a plurality of inserts, each insert at least partially defining a fastener aperture sized and dimensioned for receiving a fastener; and
a plurality of fasteners, each fastener received in the fastener aperture of each insert for engaging one of the adjacent vertebrae,
wherein each insert is coupled to the spacer such that at least a portion of the insert is received in the cutout in the spacer wherein the superior surface and the inferior surface are configured with a roughened or porous surface, and
wherein the plurality of inserts are spaced from each other,
wherein each of the fastener apertures is positioned in an oblique angle so that the plurality of fasteners extend at an angle from a longitudinal axis of the spacer and configured to engage with one of the adjacent vertebrae,
wherein the spacer includes torsional stabilizers on the superior and inferior surfaces opposite the plurality of inserts.

US Pat. No. 10,137,000

METHOD AND APPARATUS FOR PLACEMENT INTO IATROGENICALLY CREATED SKELETAL VOIDS

1. A method of placing an implant into an iatrogenically created skeletal void within an individual vertebral body, the method comprising:creating a void by removing at least a portion of the individual vertebral body while leaving superior and inferior endplates functionally intact, the void extending through the individual vertebral body from an anterior wall through a posterior wall; and
placing the implant within the void between the superior endplate and the inferior endplate of the individual vertebra such that the implant does not engage with adjacent vertebra thereby permitting the endplates to perform their function.

US Pat. No. 10,136,998

REVISION TOTAL ANKLE IMPLANTS

Wright Medical Technology...

1. A revision implant, comprising:a body extending between a first planar surface and a second planar surface;
a head extending from the first planar surface of the body and configured to couple the revision implant to an additional component of a multi-component prosthesis;
at least one coupling mechanism configured to couple the body to a first bone, wherein the at least one coupling mechanism comprises one or more protrusions extending from the second planar surface of the body; and
a dome-shaped projection extending from the second planar surface and defining a first fastener hole configured to receive a fastener coupling an augment to the body, where the augment is configured to fill a void of the first bone;
wherein the head defines a second fastener hole configured to receive the fastener.

US Pat. No. 10,136,996

IMPLANTABLE PROSTHESIS FOR REPLACING THE HUMAN KNEE JOINT

1. An implantable prosthesis for replacing a human knee joint, comprising:a femoral prosthetic element and a tibial prosthetic element which are articulated with one another by means of a joint device for the purpose of executing a knee bend, the tibial prosthetic element having a through-opening for the passage of a tool, a rod-like tibial shaft anchoring part or an intramedullary lengthening nail,
wherein the joint device is designed to form a guide channel for the passage of the tool, the rod-like tibial shaft anchoring part or the intramedullary lengthening nail from outside, which guide channel is in alignment with the through-opening and is in connection therewith when the tibial prosthetic element and the femoral prosthetic element are arranged at a predetermined angle relative to one another in a functional position corresponding to a knee bend, and
wherein the joint device comprises a joint head which is connected to the femoral prosthetic element and has an interior space in which a joint element connected to the tibial prosthetic element is rotatably guided for guiding the knee bend, a passage opening into the interior space being formed in the joint head and a through-bore being formed in the joint element, the passage and the through-bore being in alignment with one another in the functional position to form the guide channel.

US Pat. No. 10,136,994

COMPOSITE INTERBODY DEVICE AND ASSOCIATED MANUFACTURING METHOD

SB Technologies, LLC, Pa...

1. A composite interbody device, comprising:a plastic core having a superior surface and an inferior surface;
a superior endplate and an inferior endplate, each of the superior and inferior endplates including:
(a) a bone interface side for interfacing with bone and having a plurality of pores permitting bone growth therein, and
(b) a core interface side, opposite the bone interface side, having a plurality of voids that accommodate material of the plastic core to couple the endplate to a respective one of the superior and inferior surfaces, the voids being non-porously isolated from the pores to prevent the material of the plastic core from entering the pores.

US Pat. No. 10,136,993

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair system for repairing a native valve of a patient during a non-open heart procedure, the valve repair system comprising:a delivery device having at least one lumen;
a valve repair device configured to be delivered through the lumen of the delivery device, and configured to attach to a native valve of a patient, the valve repair device comprising:
a pair of paddles that are movable between an open position and a closed position;
wherein each paddle includes a main portion and first and second side portions that are integrally formed with the main portion and extend from the main portion and are configured to contour to the shape of the native valve;
wherein the pair of paddles are configured such that the first and second side portions flex away from the main portion upon being attached to the native valve of the patient; and
a pair of gripping members that are configured to attach to the native valve of the patient.

US Pat. No. 10,136,984

SYSTEMS AND METHODS FOR MESH AUGMENTATION AND PREVENTION OF INCISIONAL HERNIA

THE TRUSTEES OF THE UNIVE...

1. A method for affixing mesh to a fascial incision to reinforce and augment hernia fascia closures, comprising:aligning a mesh strip over the fascial incision using an applicator, the mesh strip being integrated with one or more uni-directional fasteners, each fastener including at least one anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface, the applicator comprising a first tension arm and a second tension arm adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the first and second tension arms adapted to spread the first and second tension arms;
controlling a first horizontal tension of the mesh strip when the mesh strip is placed on the fascial incision by using the handle to spread the first tension arm a first distance from the second tension arm, the first distance corresponding to the first horizontal tension of the mesh strip, wherein the first horizontal tension corresponds to a predetermined amount of horizontal tension applied to the mesh strip by the applicator without application of external force;
affixing the mesh strip under the vertical tension and the first horizontal tension to the anterior abdominal wall fascia by applying a force to the fasteners to thereby achieve tissue penetration of the at least one anchoring mechanism of the one or more fasteners; and incrementally tensioning the mesh strip placed on the fascial incision to reinforce the fascial incision by using the handle to spread the first tension arm from the second tension arm by a second distance that is greater than the first distance, wherein an incremental horizontal tension corresponds to the second distance, the incremental horizontal tension being greater than the first horizontal tension.

US Pat. No. 10,136,982

POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS

Tepha, Inc., Lexington, ...

1. A knitted mesh, woven mesh, nonwoven mesh or braid comprising a poly-hydroxybutyrate homopolymer multifilament yarn, wherein the multifilament yarn has a tenacity of greater than 0.5 g/denier and is produced by a method comprising melt extrusion, allowing the extrudate dwell time to crystallize and drawing the resulting fiber.

US Pat. No. 10,136,981

TISSUE ANCHOR SYSTEM INCLUDING A SUTURE SECURING AN ANCHOR TO A SUPPORT

1. A tissue anchor system comprising:a support having a base and arms extending from the base, where the arms include a first arm separated from a second arm by a central portion of the support, where the support is a knitted mesh having open pores;
a suture inserted through the support, with a first trailing end portion and a second trailing end portion of the suture maintained inside of a conduit;
an anchor comprising a body, a fin extending from the body in a first direction with an eyelet formed in the fin, a pair of radial barrels extending from opposite sides of the body in a radial direction perpendicular to the first direction, with the suture engaged with the eyelet of the fin, and a gripping tab removably attached to the fin, where the gripping tab is adapted to be removed from the fin prior to insertion of the anchor into tissue; and
an introducer having a cannula defining a bore sized to receive the body of the anchor and a slot formed in a wall of the cannula, with the slot sized to receive the fin of the anchor.

US Pat. No. 10,136,980

IMPLANTS AND PROCEDURES FOR SUPPORTING ANATOMICAL STRUCTURES FOR TREATING CONDITIONS SUCH AS PELVIC ORGAN PROLAPSE

Caldera Medical, Inc., A...

1. A method for supporting an anatomical structure comprising:(a) making an entry point in a body of a patient;
(b) engaging a first anchor with a delivery system and inserting the first anchor through the entry point and into a target tissue of the body;
(c) retracting the delivery system from the first anchor and out from the entry point;
(d) reengaging the delivery system with the first anchor by passing a suture extending from the first anchor and out the entry point through a slot in the delivery system and advancing the delivery system towards the first anchor until the first anchor is received by the delivery system;
(e) adjusting a position of the first anchor in the target tissue with the delivery system and retracting the delivery system from the first anchor and out from the entry point after said adjusting;
(f) positioning a support member between the first anchor and a second anchor secured within said body;
(g) locking said support member in position relative to the first and second anchors by passing a mesh portion of the support member through an aperture of one of the first and second anchors and engaging said mesh portion of said support member with projections extending from an interior of the aperture by releasing a tension of a suture loop that passes through said aperture; and
(h) closing said entry point.

US Pat. No. 10,136,979

METHOD FOR CONTROLLING FLOW OF INTESTINAL CONTENTS IN A PATIENT'S INTESTINES

1. An intestinal dysfunction treatment apparatus comprising:an implantable constriction device configured to gently constrict at least one wall portion of a tissue wall of a patient's intestines to restrict a flow of intestinal contents in an intestinal passageway of the intestine's,
a stimulation device configured to stimulate the at least one wall portion of the tissue wall, and
a control device configured to be operable to control the stimulation device to stimulate the at least one wall portion, as the constriction device constricts the at least one wall portion, to cause contraction of the at least one wall portion to further restrict the flow of intestinal contents, wherein the control device is configured to control the constriction device to adjust the constriction of the at least one wall portion, and the control device is configured to control the constriction and stimulation devices independently of each other,
wherein the control device is configured to calibrate the constriction of the at least one wall portion by stimulating the at least one wall portion while adjusting, the constriction of the at least one wall portion until a desired restriction of the flow of intestinal contents in the intestinal passageway is obtained.

US Pat. No. 10,136,978

DOSING APPARATUS

Imaginus Limited, (NZ)

1. A dosing apparatus for dispensing therapeutic and/or preventative product into an orifice of an animal, comprising:a plurality of interlocking cartridges arranged in a stack, each cartridge containing at least one product, and each cartridge including:
a body with a cavity holding at least one product to be dosed,
a nozzle which is in communication with the cavity and which is configured for channelling the product to an orifice of an animal, the nozzle being disposed on the top of the body whereby product is dispensed upwardly from the dosing apparatus to the orifice of the animal,
at least one piston configured to push product from the cavity, and
a recess which is adapted to receive and provide a cover for the nozzle of an identical or similar cartridge; and
a dispenser for holding the cartridges and for dispensing product from each cartridge, one after the other, the dispenser including:
a magazine adapted to receive the stack of cartridges, and
a plunger arranged to drive the piston (s) of one of the cartridges;
wherein the nozzle comprises a cannula without a needle;
wherein the nozzle comprises a tubular section sized to fit within the teat orifice of a dairy cow for mastitis prevention and treatment; and
wherein the nozzle is disposed at an angle relative to the body of 70°-90°.

US Pat. No. 10,136,977

DENTAL TESTING DEVICE FOR HEAT SENSITIVITY

1. A device for testing a heat sensitivity in teeth comprising:a base; and
a testing tip having a cushion,
wherein the cushion comprises a heating element, wherein said heating element is embedded in said cushion; and
wherein the cushion is conformable to a contour of a tooth to be tested for a heat sensitivity and is conformable to contours of different types of teeth and wherein the cushion has a left side and a right side that are mirror images of each other that allows testing of all upper and lower teeth individually; and
being capable of transferring heat energy from the cushion to the top surface and at least one side surface of a tooth tested for heat sensitivity, wherein the surface of the cushion is adaptable to the surface of the tooth for greater surface area contact between the cushion and the tooth enamel allowing for heat energy transfer to the tooth over a larger area and at a level to prevent damage to the enamel layer, the dentine layer, or pulp tissue in the tooth being tested.

US Pat. No. 10,136,976

TOOTHBRUSH VIBRATOR

M-SYSTEM CO., LTD., Osak...

1. A toothbrush vibrator comprising:a vibration applicator having a case that allows a toothbrush to pass therethrough and holds the toothbrush and applying vibration to the toothbrush, the case being hollow pillar-shaped body; and
a grip detachably connected to the vibration applicator and gripped by a user,
wherein the grip has a case that is a hollow pillar-shaped body and is capable of housing a portion of a handle of the toothbrush that protrudes from the vibration applicator toward the grip,
the vibration applicator includes a first magnet provided at a grip-side end portion of the vibration applicator,
the grip includes a second magnet provided at a vibration applicator-side end portion of the grip, and
the vibration applicator and the grip are detachably connected by force of the first magnet and the second magnet attracting each other.

US Pat. No. 10,136,971

POSITIONING JIG AND IMPROVED METHODS TO DESIGN AND MANUFACTURE DENTAL IMPLANTS

1. A method of preparing an artificial prosthesis having two or more adjacent teeth which comprises:(a) preparing an artificial tooth arrangement (ATA) with two or more adjacent teeth in a mold on a positioning jig comprising a member with (i) three or more parallel bores in the member and (ii) one or more means for attaching the member to a dental articulator;
(b) placing at least three rigid struts in the parallel bores of the positioning jig;
(c) using at least one of the rigid struts to align a drill;
(d) drilling an aligned hole into each of the teeth in the mold;
(e) placing a rod in each of the aligned holes of the teeth to form a series of aligned rods;
(f) using the teeth and the aligned rods to prepare a dental mockup;
(g) copying the dental mockup to prepare a dental bridge; and
(h) affixing the teeth using the aligned holes to the dental bridge so as to prepare the artificial prosthesis.

US Pat. No. 10,136,968

DISPOSABLE SURGICAL INTERVENTION GUIDES, METHODS, AND KITS

ISETHCO LLC, San Diego, ...

1. A removable modular surgical guide assembly, comprising:a deformable casting medium, wherein the deformable casting medium defines an open treatment area when positioned on a dentiture of a subject;
a foundation plate circumscribing the open treatment area; and
a sensor array affixed to the foundation plate, the sensor array comprising a flexible circuit having at least two electromagnetic sensors, wherein the at least two sensors are positionable around the open treatment area at, or about at, a gumline of the dentiture of the subject,
wherein the foundation plate and the deformable casting medium are comprised of different materials, and the foundation plate is positioned in contact with the deformable casting medium.

US Pat. No. 10,136,966

ORTHODONTIC APPLIANCE

Dentbend BVBA, Liederker...

1. An orthodontic appliance comprising:a plurality of brackets, each bracket having a base for connection to a surface of a tooth within a row of teeth; and
a body configured to be coupled to each of said brackets, the body being provided with a plurality of connection elements arranged on the body, each connection element being configured to cooperate with a respective one of the plurality of brackets to form a connection between the body and the respective bracket,
wherein each connection element comprises a slot,
wherein each bracket comprises a locking element and a stem protruding from the base to connect the locking element to the base, the locking element being configured to be inserted into the slot of a respective connection element, the locking element being substantially disc-shaped and elongated in a primary axis of the respective tooth and having a larger diameter than the stem,
wherein the locking elements of the plurality of brackets and the slots of the plurality of connection elements define locking means for removably connecting the body to the plurality of brackets via the plurality of connection elements,
wherein the slot of each connection element is configured to fit around the locking element of the respective bracket, the slot comprising mating surfaces configured to form a mating engagement with the locking element of the respective bracket and at least one guiding surface configured to guide a top surface of the locking element into the slot, said at least one guiding surface running inward starting at a lower edge of the slot, the slot being a latching slot comprising a tip or protruding section at an interface between said at least one guiding surface and said mating surfaces,
wherein each connection element further comprises a first aperture through which the locking element of the respective bracket can be inserted into the slot and a second aperture configured to slide over the stem of the respective bracket,
wherein the stems of the plurality of brackets are configured so that a distance between the body and the row of teeth is sufficient for insertion and removal of the body and for cleaning of the brackets,
wherein the stem of each of the plurality of brackets is arranged on the base outside of a center of the base and a central axis of the stem is shifted with respect to a central axis of the base such that the stem is configured to define a position of the body that is shifted along the primary axis of the respective tooth with respect to a plane extending perpendicular to the primary axis of the respective tooth and through a center of the row of teeth.

US Pat. No. 10,136,962

MULTI-PLANAR PRE-CURVED ROTARY ENDODONTIC FILE

Dentsply Sirona, Inc., Y...

1. An improvement endodontic instrument configured for use in a rotary hand piece and having a working length made of a shape memory material and including a plurality of flutes forming a cutting edge, the improvement comprising:the working length including
a straight non-apical portion whose central longitudinal axis is a central rotational axis of the endodontic instrument and
a pre-curved apical portion whose central longitudinal axis does not lie along the central rotational axis of the endodontic instrument,the pre-curved apical portion beginning at about one-third to one-quarter of the working length as measured from a tip end of the endodontic instrument and ending at the tip end, the pre-curved apical portion having at least three curvatures including at least one curvature that spirals about the central rotational axis of the endodontic instrument, the at least one curvature having a radius of curvature “R” which places the tip end at an angle in a range of about 300 to 750 relative to the central rotational axis.

US Pat. No. 10,136,961

DENTIST TOOL

Viax Dental Technologies,...

1. An overlay for guiding a dental cutting tool defining a longitudinal axis in the removal of predetermined tooth structure from a tooth to be treated, the overlay comprising:an inner surface having a shape and dimensions corresponding to and configured for contacting a contact region on and extending at least partially around either of or both an outer surface of the tooth to be treated and an outer surface of a neighboring tooth of the tooth to be treated such that the inner surface remains releasably fixed to the contact region and in the same position relative to the tooth to be treated upon application of pressure to the overlay during guiding of the dental cutting tool in normal use of the overlay;
a first guiding edge extending through a thickness of the overlay including through the inner surface, the first guiding edge having a contour corresponding to any one or any combination of horizontal, vertical, and tilt movements to be followed by the dental cutting tool in a direction transverse to the longitudinal axis of the dental cutting tool; and
a second guiding edge extending through the thickness of the overlay including through the inner surface, the second guiding edge being spaced apart from the first guiding edge and having a contour corresponding to any one or any combination of the horizontal, vertical, and tilt movements to be followed by the dental cutting tool,
wherein the inner surface of the overlay is configured for extending between top and bottom portions of the respective one or both of the outer surface of the tooth to be treated and the outer surface of the neighboring tooth of the tooth to be treated to which the inner surface corresponds and on which the inner surface is configured for contacting a contact region, the inner surface of the overlay being configured for contacting the respective bottom portion or portions at a respective location or respective locations adjacent to a gingiva of the patient.

US Pat. No. 10,136,953

COMPUTER ASSISTED SURGERY APPARATUS AND METHOD OF CUTTING TISSUE

1. A computer assisted surgery apparatus, the apparatus comprising:a surgical instrument having an intervention member to cut tissue of a body part of a patient;
a control unit arranged to automatically control position and orientation of the intervention member of the surgical instrument in relation to the body part of the patient with regard to a predefined osteotomic line on the body part of the patient; and
a tracking device arranged to track a position and orientation of the body part of the patient,
wherein the surgical instrument comprises an optical monitoring system being fixedly mounted in relation to the intervention member of the surgical instrument, the optical monitoring system being arranged to continuously detect positions of marks applied to the body part of the patient, and
wherein the control unit is arranged to adjust position or orientation, or position and orientation of the intervention member of the surgical instrument when a predefined deviation of the positions of the marks is detected.

US Pat. No. 10,136,950

PATIENT-MATCHED SURGICAL COMPONENT AND METHODS OF USE

Biomet Manufacturing, LLC...

1. A method of performing a surgical procedure aided by a surgical navigation system, comprising:generating a representative model of an anatomical feature from an image of a patient's anatomy;
using the model to make a virtual surgical component;
installing the virtual surgical component on the representative model of the anatomical feature by mating the surface of the component with the anatomical feature in the predefined spatial relationship;
tracking movement of the anatomical feature with a tracking system when a physical surgical component corresponding to the virtual surgical component is moved within a measurement field of the tracking system;
tracking movement of a surgical cutting instrument with the tracking system;
displaying the representative model and the surgical cutting instrument on a display of the surgical navigation system; and
guiding the surgical cutting instrument on the display to verify a cutting plane of the surgical cutting instrument relative to the anatomical feature.

US Pat. No. 10,136,942

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,941

SURGICAL INSTRUMENT AND METHOD OF CREATING THE SAME

JSTONE INC., Mundelien, ...

1. A surgical instrument comprising:a handle portion;
a cylindrical hollow tube secured to the handle portion the cylindrical hollow tube having a first end and a second end wherein the second end of the cylindrical hollow tube is secured to the handle portion;
a clevis unit secured within a cylindrical covering wherein the cylindrical covering has a first end and a second end and wherein second end of the cylindrical covering is located adjacent to the first end of the cylindrical hollow tube;
a first blade and a second blade wherein a portion of the first blade and a portion of the second blade are secured within the clevis unit;
a rubber seal partially covered by the first end of the cylindrical hollow tube and partially covered by the second end of the cylindrical covering;
a first end of the first blade and a second end of the first blade;
a first end of the second blade and a second end of the second blade; and
wherein the second end of the first blade and the second end of the second blade do not extend outside of a circumference of the clevis unit at any time, while the first end of the first blade and the first end of the second blade extend outside of the circumference of the clevis unit.

US Pat. No. 10,136,940

APPARATUS FOR PERFORMING AN ELECTROSURGICAL PROCEDURE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a housing;
at least one shaft extending from the housing, the at least one shaft defining a longitudinalaxis;an end effector assembly operatively connected to a distal end of the at least one shaft having first and second jaw members, at least one of the first and second jaw members pivotable relative to the other from an open position wherein the first and second jaw members are disposed in spaced relation relative to one another, to a clamping position wherein the first and second jaw members cooperate to grasp tissue therebetween under a sealing pressure;
a pivot pin providing an axis of pivot for the pivotable jaw member; and
a monolithic jaw insert operably disposed within at least one of the first and second jaw members, the jaw insert defining an opening configured to securely house the pivot pin, the jaw insert including a moveable member configured to engage a cam pin and configured to provide a camming force to the cam pin and a portion of the sealing pressure to the jaw members when the first and second jaw members are in the clamping position.

US Pat. No. 10,136,938

ELECTROSURGICAL INSTRUMENT WITH SENSOR

Ethicon LLC, Guaynabo, P...

1. An apparatus for operating on tissue, the apparatus comprising:(a) a body;
(b) a shaft extending distally from the body;
(c) an end effector configured to receive energy from an energy source, wherein the end effector comprises:
(i) a first jaw, and
(ii) a second jaw, wherein the second jaw is pivotable relative to the first jaw to transition the end effector from an open configuration to a closed configuration, wherein the first jaw and second jaw define a closure gap between each other when the end effector is in the closed configuration;
(d) a first movable member operatively coupled with the second jaw, wherein the first movable member is configured to move in response to pivoting of the second jaw relative to the first jaw; and
(e) a sensor, wherein the sensor includes a second movable member configured to be engaged by the first movable member, wherein the second movable member is moveable from a first position to a second position in response to movement of the first moveable member when the end effector transitions from the open configuration to the closed configuration,
wherein the sensor is operable to detect that the end effector is in the closed configuration when the second movable member moves to the second position, wherein the sensor is in communication with the energy source, wherein the sensor is operable to communicate a signal to the energy source when the sensor detects the end effector in the closed configuration.

US Pat. No. 10,136,932

SPINAL PLATE AND DISTRACTION/COMPRESSION PIN SYSTEM

Camber Spine Technologies...

1. A cervical fixation plate and distraction pin system comprisingtwo or more distraction pins, and
a cervical fixation plate comprising
two or more boreholes for insertion of screws to position and secure the plate on the vertebral surfaces, and
two or more slots for placement of the two or more distraction pins,
wherein one of the slots is located at the inferior end of the plate and another of the slots is located at the superior end of the plate,
wherein each of the slots comprises two parallel straight side walls, and each of the slots is elongated along a longitudinal axis extending along a centerline of the plate, and wherein at least a portion of each of the side walls is ridged and contains a plurality of teeth, wherein the teeth are configured to mate with and secure the plate to a respective one of the pins and are configured to create and maintain compression across a disc space prior to and during securing of the plate on the vertebral surfaces,
wherein two of the boreholes are aligned along an axis substantially parallel to the longitudinal axis, the two boreholes disposed laterally with respect to each of the slots, and
wherein each pin comprises a threaded bone entry end and a ridged portion configured to retain the pin in the respective one of the two or more slots to secure the plate to the vertebral surfaces before attaching the screws, and wherein each pin is configured for removal from the respective one of the two or more slots.

US Pat. No. 10,136,931

BONE FIXATION DEVICE AND METHOD

1. An apparatus for fixation of a fractured bone, comprising:an elongated fixation plate having a longitudinal axis adapted to extend along a long axis of the fractured bone and including a first portion extending along the longitudinal axis of the fixation plate adapted for attachment to a first fragment of the fractured bone and a second portion extending in an opposite direction from the first portion along the longitudinal axis of the plate adapted for attachment to a second fragment of the fractured bone such that the fixation plate is adapted to extend across a fracture between the first fragment and the second fragment of the fractured bone;
a rotational member having a body and a first tab and a second tab extending outwardly and bending in a direction away from a plane of the body; and
a fastener for attaching the body of the rotation member to the elongated fixation plate;
wherein the tabs extending outwardly from the body are adapted for engaging the fractured bone to apply force to the first and second fragments transversely across opposite sides of the fractured bone to produce a torque across the fracture.

US Pat. No. 10,136,930

FLEXIBLE FASTENING DEVICE FOR INDUSTRIAL USE

1. A flexible fastening device to secure two components having curved or misaligned entry paths adjacent one another, said flexible fastening device being a rigid material and having:a body, said body having a length and a diameter, said length to diameter aspect ratio being at least 2, and multiple segments,
one of said multiple segments being a leading segment,
at least one of said multiple segments being a hollow segment;
at least two sinuous slots along at least a portion of said hollow segment to form at least one flexible segment, a first of said at least two sinuous slots extending along a first portion of said hollow segment and a second of said at least two sinuous slots extending along a second portion of said hollow segment,
one of said multiple segments being a trailing segment having a receiving area to receive a rotational force device.

US Pat. No. 10,136,929

FLEXIBLE BONE IMPLANT

IntraFuse, LLC, Logan, U...

1. A bone implant comprising an elongate body having a distal portion and a proximal portion spaced longitudinally relative to a longitudinal axis, wherein:the proximal portion comprises:
a non-threaded outer surface; and
a fully-bounded transverse bore passing through the proximal portion from a first fully-bounded opening in the non-threaded outer surface to a second fully-bounded opening in the non-threaded outer surface; and
the distal portion comprises a helical distal thread formed thereon, the helical distal thread having a major diameter, a minor diameter, and a pitch, the helical distal thread being operable to bend as it is threaded into a bone to follow a curved path, the helical distal thread having a bending stiffness lesser than a bending stiffness of the proximal portion,
wherein a ratio of a bending stiffness of the proximal portion to the bending stiffness of the distal portion is in the range of 2:1 to 20:1.

US Pat. No. 10,136,928

ROD LINK REDUCER

Globus Medical, Inc., Au...

1. A rod link reducer assembly comprising:a manipulator rod having a first end, a second end, and an elongate body extending along a body axis between the first end and the second end;
a post extending outwardly from the rod; and
a rod manipulating joint comprising:
an elongate joint rod extending along a joint rod axis;
a first coupling clamp disposed along the joint rod, the first coupling clamp releasably connectable to the post;
a second coupling clamp disposed along the joint rod adjacent to and rotatable about the joint rod relative to the first coupling clamp, the second coupling clamp releasably connectable to a second post; and
a first biasing member adapted to bias the second clamp against the first clamp,
at least two screw assemblies, a construct adapted to extend between the at least two screw assemblies,
wherein the second end of the manipulator rod comprises a tip, the tip comprising a receiver adapted to releasably secure the construct therein and a receiver axis extending orthogonally to the body axis,
wherein the receiver further comprises a securing member to releasably secure the construct to the receiver, the securing member extending at an angle oblique to the receiver axis, and
wherein the securing member comprises a set screw engaged with a threaded passage and a retainer pin located in the passage to prevent removal of the set screw from the passage.

US Pat. No. 10,136,923

POLYAXIAL BONE FIXATION ELEMENT

DePuy Synthes Products, I...

1. An assembly configured to couple a spinal rod to a vertebra, the assembly comprising:a body that is elongate along a first longitudinal axis, the body including an upper end that defines an upper opening, a lower end that defines a lower opening, a bore that extends between the upper opening and the lower opening along the longitudinal axis, the bore defining a rod-receiving channel configured to receive the spinal rod, the rod-receiving channel disposed along a channel axis that is oriented substantially perpendicular to the longitudinal axis, the bore at least partially defined by a first curved surface that forms a first spherical undercut having a first body diameter, and the bore at least partially defined by a second curved surface that forms a second spherical undercut having a second body diameter that is larger than the first body diameter, the first curved surface positioned closer to the lower opening with respect to a direction parallel to the longitudinal axis than the second curved surface is to the lower opening with respect to the direction, the body further including a collet retention feature positioned at a fixed location between the upper opening and the second curved surface such that the collet retention feature is configured to inhibit movement of a collet that is between the collet retention feature and the lower opening from passing through the upper opening, the collet retention feature defining a retention opening having a third body diameter, and the lower opening defining a fourth body diameter; and
a bone anchor that is elongate along a second longitudinal axis, the bone anchor including a head portion, a shaft portion, and a neck portion positioned between the head portion and the shaft portion, the head portion defining a first screw diameter measured perpendicular to the second longitudinal axis, the shaft portion defining a second screw diameter measured perpendicular to the second longitudinal axis, and the neck portion defining a third screw diameter perpendicular to the second longitudinal axis,
wherein the third screw diameter is less than both the first screw diameter and the second screw diameter, the first screw diameter is less than both the first body diameter and the second body diameter, and the third body diameter is greater than the fourth body diameter and less than the second body diameter.

US Pat. No. 10,136,922

BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE

1. A bone anchoring device comprising:a bone anchoring element;
a receiving part for coupling a rod to the bone anchoring element, the receiving part comprising:
a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving the rod, the recess extending from the first end in a direction of the second end and defining two free legs; and
a second portion at the second end of the rod receiving portion that is connectable to the bone anchoring element, wherein when the bone anchoring element is connected to the second portion of the receiving part, the bone anchoring element and the receiving part are pivotable relative to one another; and
a locking ring configured to be arranged around the second portion of the receiving part, the locking ring comprising a first end, a second end, and an outer surface extending between the first and second ends;
wherein when the bone anchoring element is connected to the second portion of the receiving part and the locking ring is around the second portion, the locking ring can assume a locking position where a compressive force is exerted on the bone anchoring element to lock an angular position of the bone anchoring element relative to the receiving part; and
wherein an engagement structure comprising a projection or a groove is provided on the outer surface of the locking ring, and wherein a portion of the engagement structure forms an abutting surface positioned away from end faces at the first and second ends of the locking ring that is configured to be pushed by a tool to move the locking ring away from the first end of the rod receiving portion towards the locking position, the abutting surface having at least a section that extends axially when viewed in a circumferential direction around the locking ring.

US Pat. No. 10,136,920

ADJUSTABLE CALCANEAL RESTRAINT SYSTEM

1. A treatment method for treating injuries to a patient's calcaneus performing a first surgical procedure wherein a calcaneal pin aperture is created laterally through a patient's calcaneus;inserting a calcaneal pin transversely through the patient's calcaneus;
providing an adjustable calcaneal restraint apparatus, the adjustable calcaneal restraint apparatus comprising:
a rigid framework with a first end configured to be affixed to a lower leg of the patient, and a second end configured for support transverse to the patient's heel;
an adjustment member operably connected to a first end and a second end of the calcaneal pin by a cable, the adjustment member being movably mounted to the second end of the rigid framework such that it can be set in transverse positions across the second end of the rigid framework; and
wherein movement of the adjustment member relative to the second end of the rigid framework changes the calcaneus pin angle;
securing the adjustable calcaneal restraint apparatus to the patient;
adjusting the adjustable calcaneal restraint apparatus to manipulate the patient's calcaneus or pieces of the patient's calcaneus;
imparting a biasing force on the cable between the adjustment member and the calcaneal pin;
waiting an amount of time for the patient's calcaneal and surrounding tissue to be in a desirable condition to perform a second surgical procedure; and
performing the second surgical procedure on the patient's calcaneus to fix the calcaneus or pieces of the calcaneus in a desired location while the adjustable calcaneal restraint apparatus is fixed to the patient.

US Pat. No. 10,136,915

ULTRASOUND NEEDLE GUIDE APPARATUS

LOVING HEART MEDICAL TECH...

1. An ultrasound needle guide apparatus to aid guidance of a puncturing needle to locate blood vessel positions of a living body and perform puncturing operation, comprising:an ultrasound detection device including a probe head which is configured to contact with the living body to detect the blood vessel positions via ultrasonic waves, a grip shell connected to the probe head, a first hinge portion located on the grip shell, and an image process unit located in the grip shell and electrically connected to the probe head;
a display element which is rotatably connected to the grip shell and includes a second hinge portion hinged on the first hinge portion and a display screen electrically connected to the image process unit through the first hinge portion and the second hinge portion to get ultrasonic signals from the probe head and display the blood vessel positions of the living body; and
a needle positioning aid element fastened to the ultrasound detection device and located beside the probe head, including a body fixed on the ultrasound detection device and a positioning aid support portion located at one side of the body remote from the ultrasound detection device to aid positioning of the puncturing needle;
wherein the body includes a curved section and two clamp sections at two ends of the curved section, the two clamp sections is corresponding with the curved section to clamp the grip shell from two sides of the grip shell, the grip shell includes two guide trough respectively corresponding to the two clamp sections that has an axis perpendicular to the probe head.

US Pat. No. 10,136,908

COAXIAL COIL LOCK

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing;
an elongated shaft extending distally from the housing and defining a longitudinal axis, the elongated shaft including a flexible portion configured to movably support an end effector such that, bending of the flexible portion is configured to induce pivotal movement of the end effector with respect to the longitudinal axis; and
a locking mechanism coaxially disposed about the flexible portion and selectively rotatable relative to the flexible portion about the longitudinal axis, wherein upon rotation of the locking mechanism about the longitudinal axis in a first direction, the locking mechanism is configured to laterally engage the flexible portion to impede bending of the flexible portion and pivotal movement of the end effector, and wherein upon rotation of the locking mechanism about the longitudinal axis in a second direction, the locking mechanism is configured to laterally disengage from the flexible portion enabling flexure of the flexible portion and pivotal movement of the end effector.

US Pat. No. 10,136,904

ANKLE REPLACEMENT SYSTEM AND METHOD

Wright Medical Technology...

1. A surgical device, comprising:a body including a handle disposed at a first end and a locking protrusion extending in a direction away from a longitudinal direction of the body, the locking protrusion defining an opening and defining a hole that extends parallel to the longitudinal direction of the body;
a locking tab slidably received within the opening defined by the locking protrusion, the locking tab defining an aperture having first and second portions, the first portion being narrower than the second portion, the locking tab being sized and configured to be received within the opening defined by the locking protrusion of the body;
a pair of spaced apart rails configured to be disposed along a length of the body; and
a plunger rod sized and configured to be received slidably within a threaded hole defined by the handle, the aperture defined by the locking tab, and the hole defined by the locking protrusion, wherein the plunger rod comprises a handle at a proximal end and a shoulder having an enlarged diameter along a length of the plunger rod with a threaded portion adjacent to the shoulder, the threaded portion configured to engage the threaded hole defined by the handle, the plunger rod further comprising a reduced diameter region adjacent to a distal end of the plunger rod, the reduced diameter region having a diameter that is sized and configured to be received within the first portion of the aperture defined by the locking tab for locking the plunger rod in a retracted position,
wherein the surgical device is configured to be coupled releasably to a first implant component and to guide a second implant component into position with respect to the first implant component.

US Pat. No. 10,136,903

TOURNIQUET AND METHOD THEREOF HAVING COMPLIANCE LOGGING AND ALERT FEATURES, AND A SYSTEM THEREOF

Patrick James Lynch, Haw...

1. A tourniquet for blood constriction using a strap and a clasp connected to the strap, which is adjustably configured, and communicable with an external communication apparatus configured to transmit a logging confirmation signal to the tourniquet confirming a successful logging of compliance, the tourniquet comprising:a controller;
an indicator connected to the controller;
a first sensor connected to the controller; and
a housing containing the controller and the first sensor,
wherein the housing includes a receptacle configured to receive the clasp,
wherein the first sensor is configured to output a first signal when the clasp is inserted into the receptacle, and
wherein the controller comprises:
a first communication interface configured to communicate with the external communication apparatus;
a memory; and
a processor configured to execute:
a first determining task that determines whether the clasp has been inserted in the receptacle based on whether the first signal is received;
a first communication task that controls the first communication interface to initiate communication with the external communication apparatus upon the first determining task determining that the clasp has been inserted; and
an alerting task that controls the indicator to alert a user confirming whether the compliance has been satisfied.

US Pat. No. 10,136,899

CLAMP FOR USE WITH A CUTTING DEVICE

PRICE INVENA APS, Copenh...

1. A clamp comprising:a first leg having an inner face comprising a clamping bed,
a second leg attached at one end to the first leg at one end of said clamping bed by a resilient hinge by which the legs are sprung apart, said second leg having an inner face comprising a clamping bed extending part of the length of the inner face of said second leg from the hinge attached end of said second leg, and a recessed section extending from the clamping bed of said second leg to an opposite end of said second leg;
a third leg attached to said first leg at an opposite end of said clamping bed of the first leg by a resilient hinge by which the third and first legs are sprung apart, said third leg comprising a clamping bed extending the length of an inner face of said third leg, and a contact section on an outer face of said third leg;
wherein said first leg, said second leg and said third leg together form a cavity capable of receiving an object to be clamped,
wherein pressing said second leg towards the first leg against the resilience of the hinge joining them causes said recessed section of the second leg to contact said contact section on said third leg such that said third leg is pressed towards the first leg against the resilience of the hinge joining them,
wherein said recessed section is recessed such that said third leg fits into said recessed section when said clamp is closed,
wherein the clamping beds of said second and third legs together form a contiguous clamping bed for clamping a received object against the clamping bed of the first leg when said clamp is closed, and
wherein said first leg is parallel to said second and third legs when said clamp is closed.

US Pat. No. 10,136,897

EXPANDABLE VASO-OCCLUSIVE DEVICES HAVING SHAPE MEMORY AND METHODS OF USING THE SAME

Boston Scientific Scimed,...

1. A vaso-occlusive device comprising an elongated device portion and one or more expandable components which comprise a shape memory material and which expand laterally outward from the elongated device portion upon being subjected to an increase in temperature from below a thermal transition temperature of the shape memory material to above the thermal transition temperature of the shape memory material.

US Pat. No. 10,136,891

NATURALLY DERIVED BIOABSORBABLE POLYMER GEL ADHESIVE FOR RELEASABLY ATTACHING A STAPLE BUTTRESS TO A SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

11. A surgical stapler end effector, the end effector comprising:(a) a staple cartridge, wherein the staple cartridge comprises a deck;
(b) an anvil, wherein the anvil is movable from an open position toward the staple cartridge to reach a closed position, wherein the anvil includes an underside;
(c) a buttress assembly, wherein the buttress assembly comprises:
(i) a buttress body, and
(ii) an adhesive material, wherein the adhesive material is configured to removably secure the buttress body to the deck of the staple cartridge or the underside of the anvil; and
(d) a retainer, wherein the retainer is configured to releasably hold the buttress body and wherein the retainer includes an injection port that is configured to receive a syringe needle to thereby permit injection of the adhesive.

US Pat. No. 10,136,890

STAPLE CARTRIDGE COMPRISING A VARIABLE THICKNESS COMPRESSIBLE PORTION

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:an anvil, comprising a longitudinal row of first forming pockets and a longitudinal row of second forming pockets;
a firing member comprising a first cam and a second cam, wherein said first cam comprises a resilient pad, and wherein said second cam is configured to engage said anvil;
a staple cartridge, wherein said staple cartridge is movable relative to said anvil between a first position and a second position, and wherein said staple cartridge comprises:
a cartridge body, comprising:
a deck, comprising:
a longitudinal slot;
a first deck surface positioned on a first side of said longitudinal slot; and
a second deck surface positioned on a second side of said longitudinal slot;
a bottom portion positioned opposite said deck;
a proximal end;
a distal end;
a longitudinal row of first staple cavities extending between said proximal end and said distal end, wherein said first forming pockets are positioned relative to said first staple cavities when said staple cartridge is in said second position; and
a longitudinal row of second staple cavities extending between said proximal end and said distal end, wherein said second forming pockets are positioned relative to said second staple cavities when said staple cartridge is in said second position, and wherein each said first staple cavity and said second staple cavity comprises an opening in said deck;
a metal support extending under said bottom portion, wherein said metal support comprises a bottom cam surface configured to be engaged by said first cam of said firing member to position said cartridge body relative to said anvil;
a plurality of first staple drivers movable between an unfired position and a fired position, wherein each said first staple driver comprises a first support cradle, and wherein a first distance is defined between each said first support cradle and a said first forming pocket when said first staple drivers are in said unfired position;
a plurality of second staple drivers movable between an unfired position and a fired position, wherein each said second staple driver comprises a second staple support cradle, wherein a second distance is defined between each said second support cradle and a said second forming pocket when said second staple drivers are in said unfired position, and wherein said first distance is different than said second distance;
a plurality of first staples, wherein each said first staple is positioned in a said first staple cavity and supported by a said first support cradle, and wherein said first staples comprise a first unformed height;
a plurality of second staples, wherein each said second staple is positioned in a said second staple cavity and supported by a said second support cradle, wherein said second staples comprise a second unformed height, and wherein said first unformed height is different than said second unformed height;
a first tissue thickness compensator, wherein said first tissue thickness compensator comprises polyglycolic acid, wherein said first tissue thickness compensator extends across said longitudinal slot between said first deck surface and said second deck surface, wherein said first tissue thickness compensator comprises a first portion on a first side of said longitudinal slot and a second portion on said first side of said longitudinal slot, wherein said first portion is positioned closer to said longitudinal slot than said second portion, wherein said first portion is aligned with said first staple cavities and is configured to be captured within said first staples along with tissue having a variable thickness, wherein said second portion is aligned with said second staple cavities and is configured to be captured within said second staples along with tissue having a variable thickness, and wherein said first portion is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a first proximal anchor; and
a first distal anchor, wherein said first proximal anchor and said first distal anchor are configured to releasably hold said first tissue thickness compensator to said cartridge body, and wherein said first proximal anchor and said first distal anchor are configured to be incised to release said first tissue thickness compensator from said cartridge body;
a second tissue thickness compensator, wherein said second tissue thickness compensator comprises polyglycolic acid, wherein said second tissue thickness compensator is configured to be captured within said first staples and said second staples along with the tissue having a variable thickness, and wherein said second tissue thickness compensator is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a second proximal anchor;
a second distal anchor, wherein said second proximal anchor and said second distal anchor are configured to releasably hold said second tissue thickness compensator to said anvil, and wherein said second proximal anchor and said second distal anchor are configured to be incised to release said second tissue thickness compensator from said anvil; and
a joint configured to rotatably connected said staple cartridge to said surgical instrument.

US Pat. No. 10,136,889

SYSTEMS AND METHODS FOR CONTROLLING A SEGMENTED CIRCUIT

Ethicon LLC, Guaynabo, P...

1. A powered surgical instrument, comprising:a housing;
a shaft extending from said housing;
an end effector extending from said shaft, wherein said end effector is configured to perform at least one end effector function;
a power source;
a segmented circuit configured to control said powered surgical instrument, wherein said segmented circuit comprises:
a processor segment; and
a motor segment comprising a motor;
a voltage converter configured to supply a first voltage from said power source to said processor segment and a second voltage from said power source to said motor segment, wherein said first voltage and said second voltage are different;
a current sensor configured to measure current within said motor segment; and
a boost converter configured to increase said first voltage to said processor segment when said current exceeds a predetermined value in said motor segment.

US Pat. No. 10,136,887

DRIVE SYSTEM DECOUPLING ARRANGEMENT FOR A SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. A surgical end effector, comprising:a drive system, comprising:
a proximal assembly comprising a first translatable element, wherein a first aperture is defined in the first translatable element; and
a distal assembly comprising a second translatable element, wherein the second translatable element is releasably coupled to the first translatable element, and wherein a second aperture is defined in the second translatable element;
a pin removably positioned in the first aperture and the second aperture; and
a housing, wherein the drive system is positioned within the housing, wherein the pin is accessible from outside of the housing, wherein the proximal assembly is configured to receive a drive motion from a motor, and wherein the pin is configured to transfer the drive motion from the proximal assembly to the distal assembly when the pin is positioned in the first aperture and the second aperture.

US Pat. No. 10,136,883

METHOD OF ANCHORING A SUTURE

VentureMD Innovations, LL...

1. A method of repairing soft tissue adjacent a shoulder joint comprising:producing a bone tunnel into a bone, the bone tunnel having at least first and second openings at an exterior surface of the bone;
securing a first suture portion and a second suture portion to soft tissue;
positioning the first suture portion so that the first suture portion extends from the soft tissue to the first opening, then through the first opening, and then through the bone tunnel;
positioning the second suture portion so that the second suture portion extends, outside of the bone tunnel, from the soft tissue;
passing the first suture portion through a first transverse anchor passage in an anchor, the anchor comprising a proximal end and a distal end, the first transverse anchor passage extending transversely into the anchor at the distal end and a second transverse anchor passage extending transversely into the anchor at the proximal end;
passing the second suture portion through the second transverse anchor passage in the anchor;
inserting the anchor into the bone tunnel through the second opening; and
advancing a locking member in sliding translation along a path inside the anchor to compress the first and second suture portions between the locking member and the anchor to secure the first and second suture portions relative to the bone tunnel and the anchor, the first and second suture portions being positioned within the bone tunnel when the first and second suture portions are secured with the locking member, such that the first transverse anchor passage through the distal end substantially aligns with the first opening of the bone tunnel when the first suture portion is secured.

US Pat. No. 10,136,881

LAPAROSCOPIC RETRACTOR DEVICES

Mayo Foundation for Medic...

1. A laparoscopic retractor device comprising:a handle;
an elongate shaft with a proximal end portion that is attached to the handle, the shaft extending from the handle and terminating at a distal free end portion, the shaft defining a first lumen;
an elongate shaft linkage disposed within the first lumen, the shaft linkage having a proximal end and a distal end;
a first actuator located at the handle and coupled to the proximal end of the shaft linkage;
an expandable portion including: (i) a distal end portion coupled to the distal free end portion of the shaft and (ii) a proximal end portion coupled to the distal end of the shaft linkage, wherein moving the actuator causes the expandable portion to move radially outward from the shaft or radially inward toward the shaft; and
a sheath with a lumen therethrough, at least a portion of the shaft being disposed within the lumen, the sheath being slidable distally and proximally along the shaft.

US Pat. No. 10,136,879

SYSTEM AND METHOD FOR NON-CONTACT ELECTRONIC ARTICULATION SENSING

Covidien LP, Mansfield, ...

1. A surgical instrument, comprising:a handle portion;
a body portion extending distally from the handle portion and defining a first longitudinal axis;
an articulation tool assembly defining a second longitudinal axis and having a proximal end, the articulation tool assembly disposed at a distal end of the body portion and being movable from a first position in which the second longitudinal axis is substantially aligned with the first longitudinal axis to at least a second position in which the second longitudinal axis is disposed at an angle with respect to the first longitudinal axis;
an articulation mechanism configured to articulate the articulation tool assembly, the articulation mechanism including:
an articulation link mechanically engaged to the articulation tool assembly; and
an articulation knob mechanically engaged to the articulation link, wherein rotational motion of the articulation knob is translated into articulation movement of the articulation tool assembly through the articulation link; and
an articulation sensor assembly including:
a photo sensor disposed in spaced relation to the articulation link and configured to detect light reflected from the articulation link, the photo sensor configured to transmit a sensor signal; and
a microcontroller configured to determine an articulation angle of the articulation tool assembly based on the sensor signal.

US Pat. No. 10,136,878

AUTOMATIC DEVICE AND KIT FOR INSERTING A CANNULA TO A PREDETERMINED DEPTH WITHIN A BONE, IRRESPECTIVE OF THE THICKNESS OF THE TISSUE ABOVE THE BONE

WAISMED LTD., Herzliya (...

1. An automatic device for causing penetration of a stylet and cannula to a predefined depth ? within a bone, said depth ? being irrespective of a thickness of tissue above the bone, said device comprising:a) a trigger unit for activating the device;
b) a barrel;
c) a probe unit positioned within said barrel which is driven by a secondary spring, said probe unit comprises one or more probing needles at a distal end, and an anvil at a proximal end for defining an end of movement location for a hammer unit;
d) said hammer unit which is driven by a main spring and comprises a stylet which is longer than said one or more probing needles at its distal end, a core at its proximal end, and a piston between said core and stylet;
e) a cannula within which said stylet is inserted; and
f) one or more grasping units;
wherein when said hammer unit is positioned at said end of movement location, a tip of said stylet is located a distance ? farther in a distal direction from respective ends of said probing needles,
wherein said secondary spring, when released in response to activation of said trigger unit, is configured to push said one or more probing needles of said probe unit toward the bone, up to a point of contact with a surface of the bone,
wherein said one or more grasping units are configured to grasp the anvil of said probe unit, upon contact between said one or more probing needles and the bone surface,
wherein said main spring, when released in response to the activation of said trigger unit, is configured to push said hammer unit to said end of movement location and thereby cause penetration of said cannula to a depth of ? within the bone.

US Pat. No. 10,136,877

ULTRASOUND DIAGNOSIS APPARATUS AND IMAGE PROCESSING APPARATUS

Toshiba Medical Systems C...

1. An ultrasound diagnosis apparatus, comprising:processing circuitry configured to
generate three-dimensional image data based on reflected-wave data received by an ultrasound probe,
generate a two-dimensional tomographic image using the three-dimensional image data,
set a value of an image quality adjusting parameter used for generating a virtual endoscopic image so that a position of an internal wall of a lumen in the three-dimensional image data matches a corresponding position of the internal wall of the lumen in the two-dimensional tomographic image or so that a distance between two points on opposing sides of the internal wall of the lumen in the three-dimensional image data is equal to a corresponding distance between two points set in the two-dimensional tomographic image;
generate the virtual endoscopic image by projecting an inside of the lumen from a predetermined viewpoint and using the value of the set image quality adjusting parameter; and
cause a predetermined display to display the virtual endoscopic image.

US Pat. No. 10,136,875

ULTRASONIC DIAGNOSTIC APPARATUS AND ULTRASONIC DIAGNOSTIC METHOD

Konica Minolta, Inc., To...

1. An ultrasonic diagnostic apparatus that decides a type of a tumor contained in a specimen, the apparatus comprising:an image forming unit that forms an ultrasonic image corresponding to an echo signal received from the specimen after administration of a contrast medium;
a feature value calculating unit that classifies each of a plurality of pixel regions contained in a tumor region including the tumor in the ultrasonic image into a low-luminance region, or a high-luminance region having higher luminance than the luminance of the low-luminance region, and calculates, based on a difference between a variance at a position of the low-luminance region and a variance at a position of the high-luminance region, a ring level indicating a degree of a ring shape of an image of the tumor region, the ring shape in which a luminance value of a central portion is lower than a luminance value of a peripheral portion surrounding the central portion; and
a type deciding unit that decides the type of the tumor based on the ring level.

US Pat. No. 10,136,873

RADIOGRAPHIC IMAGE PROCESSING DEVICE, METHOD, AND RECORDING MEDIUM

FUJIFILM Corporation, Mi...

1. A radiographic image processing device comprising:at least one hardware processor configured to implement:
a frequency decomposition unit for performing frequency decomposition for a first radiographic image which is captured by irradiating a subject with radiation and acquiring a plurality of band images indicating a plurality of frequency components of the first radiographic image;
a scattered radiation removal unit for calculating a scattered radiation component that is caused by the subject and is included in a second radiographic image of the subject which has a linear relationship with an amount of radiation, using the second radiographic image, and removing the scattered radiation component from the second radiographic image to acquire a scattered-radiation-removed radiographic image;
a conversion function determination unit for determining a conversion function for converting at least one of the band images according to the scattered radiation component included in the second radiographic image;
a conversion unit for converting the at least one band image, using the conversion function, and generating a converted band image; and
a reconstruction unit for reconstructing the scattered-radiation-removed radiographic image and the converted band image to acquire a processed radiographic image,
wherein the first radiographic image has a pixel value that has a linear relationship with a logarithmic amount of radiation, and
wherein the second radiographic image is obtained by performing inverse logarithmic conversion for the first radiographic image.

US Pat. No. 10,136,872

DETERMINATION OF AN X-RAY IMAGE DATA RECORD OF A MOVING TARGET LOCATION

1. A method for determining an x-ray image data record of a target location of a patient subjected to a movement using an x-ray device, the method comprising:recording a plurality of component images of the target location using an image exposure time;
registering the plurality of component images with one another;
determining one or more quality values related to the movement of the target for each component image of the plurality of component images, the one or more quality values including at least a motion speed calculated as a comparison between a spread function of at least two or more of the plurality of component images and a reference spread function of the x-ray device;
selecting as a function of the one or more quality values a contribution of one or more basic images of the plurality of component images; and
combining the one or more component images into the x-ray image data record as a function of the selected contribution of the one or more component images.

US Pat. No. 10,136,868

FAST DUAL ENERGY FOR GENERAL RADIOGRAPHY

General Electric Company,...

1. A system, comprising:an X-ray source configured to generate X-rays directed toward an object, wherein the X-ray source is to: (i) generate a first energy X-ray pulse, (ii) switch to generate a second energy X-ray pulse, and (iii) switch back to generate another first energy X-ray pulse, wherein the second energy X-ray pulse is associated with higher voltage level as compared to the first energy X-ray pulses;
a detector associated with multiple image pixels, the detector including, for each pixel:
an X-ray sensitive element to receive X-rays,
a first storage element and associated switch to capture information associated with the first energy X-ray pulses, and
a second storage element and associated switch to capture information associated with the second energy X-ray pulse; and
a controller to synchronize the X-ray source and detector.

US Pat. No. 10,136,867

RADIOLOGICAL IMAGING SYSTEM WITH IMPROVED INTERNAL MOVEMENT

IMAGINALIS SRL, Sesto Fi...

1. A radiological imaging system, comprising:a bed;
a load-bearing structure connected to the bed and configured to support the bed; and
a gantry connected to the load-bearing structure, the gantry defining a main axis of expansion, the gantry having a source configured to emit radiation, a detector with a sensitive surface configured to detect the radiation, an internal inner guide configured to rotate the detector around the main axis of expansion defining an inner sliding trajectory, and an internal outer guide configured to rotate the source around the main axis of expansion defining an outer sliding trajectory, wherein the distance from the source to the main axis of expansion is greater than the distance from the detector to the main axis of expansion, and the gantry including a casing housing the source, the detector, the internal inner guide, and the internal outer guide,
wherein the casing includes a fixed arched module, a first mobile arched module, and a second mobile arched module.

US Pat. No. 10,136,866

RADIATION IRRADIATION DEVICE

FUJIFILM Corporation, To...

1. A radiation irradiation device comprising:a radiation generation unit that generates radiation;
an arm part having one end to which the radiation generation unit is attached;
a support member having one end to which the other end of the arm part is connected so as to be rotationally movable;
a body part to which the other end of the support member is connected; and
a leg part on which the body part is placed,
wherein in a case where a side toward which the arm part extends from the body part during use of the device is defined as a front side, the leg part includes a first caster which is provided on the front side of a bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported and a second caster which is provided on a rear side of the bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported, and
wherein a diameter of the wheel of the second caster is greater than a diameter of the wheel of the first caster, and a gravity center position of the entire device is closer to the second caster side than a center between the first caster and the second caster in a state where the arm part is rotationally moved until the radiation generation unit is located at a vertically lowermost position.

US Pat. No. 10,136,864

X-RAY COLLIMATOR SIZE AND POSITION ADJUSTMENT BASED ON PRE-SHOT

KONINKLIJKE PHILIPS N.V.,...

1. An X-ray apparatus for image acquisition, comprising:an X-ray source configured to generate X-ray radiation for image acquisition of an object;
a collimator comprising at least one moveable shutter, the collimator being configured to collimate the X-ray radiation into a radiation cone, said radiation cone irradiating the object at a region of interest when acquiring an image;
a portable radiation detector configured to register the X-ray radiation after passage through the object; and
a field-of-view corrector configured to receive, in a pre-shot imaging phase, a scout image (SI) acquired by the portable radiation detector with a tentative setting of the collimator, the pre-shot imaging phase causing a low dosage radiation cone to impinge on the portable radiation detector, the low dosage radiation cone having in an image plane of the portable radiation detector a first cross section being smaller than a surface area of the portable radiation detector,
the field-of-view corrector being further configured to use said scout image to establish field-of-view correction information for a subsequent imaging phase, the field of view correction information including collimation correction information for determining a corrected setting of the collimator,
wherein, in the subsequent imaging phase, the corrected setting of the collimator results in a high dosage radiation cone impinging on the portable radiation detector, the high dosage radiation cone providing a higher dosage of radiation than the low dosage radiation cone, and the high dosage radiation cone having, in the image plane of the portable radiation detector, a second cross section that is larger than the first cross section and the high dosage radiation cone i) being essentially coextensive with the surface area of the portable radiation detector or ii) being a symmetric enlargement of the first cross section and extending in its entirety within the surface area of the portable radiation detector.

US Pat. No. 10,136,862

METHOD OF SONIFYING BRAIN ELECTRICAL ACTIVITY

The Board of Trustees of ...

1. A method of sonifying brain signals using a digital processor system that comprises at least one processing unit, the method comprising:filtering, with a front-end module coupled to the digital processor system, a continuous time-domain sensor signal representing brain activity of a subject obtained from at least one sensor in order to generate a filtered continuous time-domain sensor signal;
producing a continuous time-domain signal representing the brain activity of the subject from the filtered continuous time-domain sensor signal using the digital processor system, the continuous time-domain signal having a time varying signal value;
concurrently generating a plurality of continuously time-varying acoustic parameters from the continuous time-domain signal using the digital processor system, the plurality of continuously time-varying acoustic parameters including a vowel-control parameter, an intensity-control parameter, and a pitch-control parameter, wherein at least three of the parameters in the plurality of continuously time-varying acoustic parameters are continuously modulated in proportion with at least the continuous time varying signal value of the time-domain signal during concurrent generation;
driving, with the digital processor system, an audio synthesizer using the concurrently generated plurality of continuously time-varying acoustic parameters, including the vowel-control parameter, the intensity-control parameter, and the pitch-control parameter, to produce a representation of an acoustic signal corresponding to the brain activity of the subject represented by the continuous time-domain signal;
performing continuous audio playback of the representation of the acoustic signal using the digital processor system, wherein performing the continuous audio playback comprises audibly providing, with at least one speaker, the representation of the acoustic signal for diagnosis and/or treatment of a condition of the subject.

US Pat. No. 10,136,859

SYSTEM AND METHOD FOR OUTPATIENT MANAGEMENT OF CHRONIC DISEASE

1. An outpatient ambulatory patient worn apparatus for managing chronic lung disease comprising:a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data, said plurality of sensors including at least one oximeter, a respiratory rate sensor, and at least one activity or motion sensor, at least said oximeter, said at least one oximeter, said respiratory rate sensor, and said at least one activity or motion sensor continuously operative to measure said plurality of physiological data in an outpatient setting during activities of daily living comprising rest, exertion, and sleep;
a central monitoring unit (CMU) communicatively coupled to said plurality of sensors and to an interface device, said CMU comprising a computer, and said CMU to be worn by the patient in said outpatient setting during activities of daily living, said CMU programmed to record concurrently a set of time stamped primary data comprising measurement data from each of said plurality of sensors to a non-volatile memory at a predetermined interval for one or more epochs of time, and to categorize at an acquisition rate or some multiple of the acquisition rate each recorded measurement of each of said plurality of sensors stored in said set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, said predominate activity type selected from a plurality of activity types including rest, exertion, and sleep; and
a generate report process running on said CMU to provide at least one or more reports in real time including at least an indication or determination of whether a chronic lung disease treatment is needed by the patient based on said set of activity type stamped data.

US Pat. No. 10,136,855

AUTOMATIC ADJUSTMENT OF HELMET PARAMETERS BASED ON A CATEGORY OF PLAY

INTERNATIONAL BUSINESS MA...

1. A method for automatic adjustment of helmet parameters based on a category of play, the method comprising:monitoring a plurality of sensors in a helmet;
determining the category of play for a user of the helmet based on data received from the plurality of sensors; and
automatically adjusting parameters of the helmet based on the category of play, wherein the parameters include at least one of a stiffness, a size and a shape of a padding of the helmet,
wherein a type of an adjustment and an amount of the adjustment are determined based on a model of expected risks for the category of play for the user.

US Pat. No. 10,136,853

CONTACTLESS SLEEP DISORDER SCREENING SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. A system configured to monitor a sleep session of a patient without making physical contact with the patient, the system comprising:a sound sensor configured to generate output signals that convey information related to sound originating from the patient in a sleeping environment;
a movement sensor comprising:
a light source configured to project a structured light pattern onto the patient which deforms when the patient moves; and
a detector configured to receive light reflected from the patient, the detector configured to generate output signals that convey information related to changes in the structured light pattern projected onto the patient caused by movement of the patient; and
one or more hardware processors configured by machine-readable instructions to:
receive and store data relating to the sound originating from the patient based on the information conveyed by the output signals from the sound sensor,
determine movement of the patient based on (1) a distance between the light source and the detector, and (2) a change in angle of reflected light from the structured light pattern received from an individual moving point on the patient, wherein images derived from the information related to changes in the structured light pattern are construed wherein an indication of motion vectors is provided, wherein the motion vectors indicate a direction and an amplitude of the movement of the patient, wherein the motion vectors facilitate segmentation of one or more body parts, and wherein information related to a mouth movement is determined based on the segmentation of the one or more body parts, and
determine a sleep disorder diagnosis based on the sound originating from the patient and the movement of the patient, wherein the one or more hardware processors are configured to determine parasomnia Bruxism based on the determined mouth movement.

US Pat. No. 10,136,851

INTEGRATED DEVICE TO MEASURE VARIATIONS IN NEUROMUSCULAR CONTROL WHEN TRACING DEFINED TARGET PATTERNS AND A SYSTEM AND METHOD OF USING THE INTEGRATED DEVICE

1. A device for measuring variations in neuromuscular control of a user, comprising:an integrated device, including:
a computing device configured to be held by the user;
a pointing device attached to, or integrated with the computing device, the pointing device including an end portion;
the computing device configured to detect three-dimensional movement data of the integrated device relative to a particular pattern predefined in the computing device while the user is tracing the pattern;
wherein the pointing device is configured for the end portion to be pointed at said pattern at a predefined distance from said pattern to trace said pattern, without the end portion physically touching the pattern.

US Pat. No. 10,136,848

DEVICE AND SYSTEM OF BLOOD COLLECTION, AND METHOD THEREOF

Winnoz Technology, Inc., ...

1. A device for collecting a blood sample, comprising:a collection unit comprising:
a top window;
a top surface;
a channel communicated with the top window;
at least one capillary tube having a top end adjacent to the top window;
wherein a distance between the top end of the at least one capillary tube and the top surface of the collection unit is in a range of 1.0 mm to 5.0 mm, such that the top end of the at least one capillary tube is used to contact with a blood drop from a puncture to continuously draw the blood flowing inside or along the at least one capillary tube into a storage unit by disrupting a surface tension of the blood drop, and
a vacuum connector communicated with the channel, extended outwardly from the collection unit, and connected to a pressure control unit to remove air from the channel and create an alternating negative pressure in the channel; and
the storage unit disposed under the collection unit.

US Pat. No. 10,136,847

MITIGATING SINGLE POINT FAILURE OF DEVICES IN AN ANALYTE MONITORING SYSTEM AND METHODS THEREOF

Abbott Diabetes Care Inc....

1. A computer-implemented method for mitigating single point failure of at least one device in an analyte monitoring system, comprising:providing a request, from a first device to a second device, that a functionality check of one or more components of a third device be performed, wherein the functionality check includes communicating, from the third device to the second device, data related to results of the functionality check;
receiving, at the first device, the data related to the results of the functionality check from the second device;
determining, by the first device, that the one or more components of the third device is not functioning in accordance with at least one predetermined criterion; and
providing, to the second device, a request from the first device that an alarm function be initiated to alert a user that the one or more components of the third device is not functioning in accordance with the at least one predetermined criterion.

US Pat. No. 10,136,845

DEVICES, SYSTEMS, AND METHODS ASSOCIATED WITH ANALYTE MONITORING DEVICES AND DEVICES INCORPORATING THE SAME

ABBOTT DIABETES CARE INC....

1. An apparatus for receiving analyte data from an in vivo analyte sensing device, comprising:a housing;
a display mounted on the housing;
an input component;
a test strip port;
a processor mounted in the housing; and
a memory storing instructions which, when executed by the processor, cause the processor to:
navigate from a current user interface screen on the display to a home screen in response to a press of the input component by a user unless a test strip is in the test strip port and a test strip result has not yet been computed;
cause display of the home screen, wherein the home screen includes an indication of the time remaining until the in vivo analyte sensing device expires; and
cause display of received analyte information,
wherein the instructions, when executed by the processor, cause the processor to render inactive the press of the input component by the user to navigate from the current user interface screen on the display to the home screen if the test strip is in the test strip port and the test strip result has not yet been computed.

US Pat. No. 10,136,842

FOOTWEAR APPARATUS WITH TECHNIQUE FEEDBACK

1. A footwear apparatus comprising:a sensor in the footwear apparatus positioned to monitor an activity technique of a user when the footwear apparatus is joined with a foot of the user, and
a feedback generator arranged to produce a haptic communication to the user in response to detecting a pattern in the activity technique, the haptic communication arranged to cause at least some discomfort to the user, wherein the pattern includes a pronation element.

US Pat. No. 10,136,838

PERSONAL SPIROMETER

PMD Healthcare, Lansdale...

1. A hand-held spirometer for correlating test results with a medical condition, said spirometer comprising:a portable housing having handles configured for said user to grip said handles to hold said housing during use;
a display on a surface of said housing;
an airflow tube through said housing;
one or more air flow sensors associated with said airflow tube;
a processor in said housing;
memory operatively connected to said processor and configured with instructions to instruct the processor to perform the following steps:
determining and recording sequential lung performance values based on data from said air flow sensors over a period;
recording user data during said period, said user data comprising at least medical compliance;
correlating said sequential lung performance values and said user data over said period; and
displaying a relationship between said sequential lung performance data and said medical compliance over said period on said display; and wherein said relationship on said display comprises a plot of lung performance per increment of time during said period with an indication of medical compliance for each said increment of time during said period.

US Pat. No. 10,136,834

NEURONAL RESONANCE MAGNETIC RESONANCE IMAGING METHOD

KOREA ADVANCED INSTITUTE ...

1. A magnetic resonance signal processing method for detecting a magnetic field oscillation signal, the method comprising:obtaining N pieces of MRI (magnetic resonance imaging) data by repeating a step of obtaining an MRI data with an MRI scheme using a gradient magnetic field pattern N number of times while changing relative phases between the gradient magnetic field pattern and the magnetic field oscillation signal; and
calculating a value related to an energy of a predetermined frequency component of an arranged signal produced by arranging the obtained N pieces of MRI data on a time-axis according to the relative phases,
wherein the N pieces of MRI data are K-space data or the N pieces of MRI data are MRI image data.

US Pat. No. 10,136,833

IMPLANTABLE RADIO-FREQUENCY SENSOR

ZOLL MEDICAL ISRAEL, LTD....

1. A diagnostic apparatus, comprising:a sealed case, comprising a biocompatible material and configured for implantation within a body;
a first antenna and a second antenna, each antenna configured to:
be implanted in the body in proximity to a target tissue,
generate and transmit radio frequency (RF) electromagnetic waves through the target tissue to the other antenna, and
output a signal in response to RF waves received from the other antenna; and
processing circuitry, which is contained within the case and is configured to receive and process the signal from each antenna so as to derive and output an indication of a characteristic of the target tissue.

US Pat. No. 10,136,830

NEUROPHYSIOLOGICAL DATA ANALYSIS USING SPATIOTEMPORAL PARCELLATION

Elminda Ltd., Herzliya (...

1. A method of analyzing neurophysiological data recorded from a brain of a subject, the method comprising:recording the neurophysiological data by a plurality of measuring devices respectively placed at a plurality of different locations on the scalp of the subject,
operating a data processor for:
identifying activity-related features in the data;
parceling the data according to said activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain and corresponding to an extremum of the data and a spatiotemporal neighborhood defined as a spatial region in which said extremum is located and a time-interval during which said extremum occurs, wherein a size of said neighborhood is determined based on a property of said extremum;
storing said capsules in a memory;
comparing at least some of said defined capsules to at least one reference capsule;
estimating a brain function of the subject based on said comparison and;
generating on a display an output indicative of said brain function.

US Pat. No. 10,136,829

SYSTEMS AND METHODS FOR USING ELECTROPHYSIOLOGY PROPERTIES FOR CLASSIFYING ARRHYTHMIA SOURCES

St. Jude Medical, Cardiol...

1. A method for determining electrophysiology properties of tissue, the method comprising:acquiring electrical signal data from a plurality of electrodes of one or more catheters;
determining at least one electrode clique from the plurality of adjacent electrodes, wherein the at least one electrode clique comprises at least three adjacent electrodes;
computing local conduction velocity vectors for the at least one electrode clique;
determining at least one catheter orientation independent indicator from which to classify an arrhythmia source based on one or more of an angular dependence parameter associated with a flow field of the local velocity conduction vectors, an eccentricity parameter reflecting the uniformity of local conduction velocity, and divergence and curl-like sums or closed path integral parameters associated with the local conduction velocity vectors; and
displaying a rhythm classification responsive to catheter movement thereby facilitating identification of types and causes of arrhythmia disorders.

US Pat. No. 10,136,826

SYSTEM AND METHOD FOR DISTINGUISHING A CARDIAC EVENT FROM NOISE IN AN ELECTROCARDIOGRAM (ECG) SIGNAL

ZOLL MEDICAL CORPORATION,...

1. A wearable defibrillator comprising:at least one therapy pad for rendering treatment to a patient wearing the wearable defibrillator;
at least one sensing electrode for obtaining an electrocardiogram (ECG) signal from the patient;
a processing unit comprising at least one processor operatively coupled to the at least one therapy pad and the at least one sensing electrode; and
at least one non-transitory computer-readable medium comprising program instructions that, when executed by the at least one processor, causes the processing unit to:
obtain the ECG signal;
determine a transformed ECG signal based on the ECG signal;
extract at least one value representing at least one feature of the transformed ECG signal;
provide the at least one value to determine a score associated with the ECG signal, thereby providing an ECG-derived score;
compare the ECG-derived score to a predetermined threshold score determined by machine learning; and
provide an indication of a cardiac event based on the comparison of the ECG-derived score with the predetermined threshold score,
wherein the transformed ECG signal comprises a power spectral density (PSD) of the ECG signal, the PSD being determined by calculating a fast Fourier transform (FFT) of the ECG signal, and
wherein at least four features of the PSD are extracted and provided to the machine learning.

US Pat. No. 10,136,825

LONG-TERM IMPLANTABLE SILICON CARBIDE NEURAL INTERFACE DEVICE USING THE ELECTRICAL FIELD EFFECT

University of South Flori...

1. An implantable neural interface device, the device comprising:a control unit;
at least one substantially planar neural probe coupled to the control unit, each of the at least one substantially planar neural probes comprising;
at least one neural tissue stimulation device comprising at least one electrolyte insulator semiconductor capacitor (EISCap) having a cubic silicon carbide (3C—SiC) base and a biocompatible and chemically resistant gate insulator, wherein neural tissue in contact with the electrolyte insulator semiconductor capacitor (EISCap) forms a gate conductor to generate an electric field to stimulate the neural tissue at least partially surrounding the at least one substantially planar neural probe; and
at least one neural tissue stimulation receiving device comprising at least one field effect transistor having a cubic silicon carbide (3C—SiC) base, wherein neural tissue in contact with the at least one field effect transistor forms a gate conductor and wherein the at least one neural tissue stimulation receiving device receives ionic changes generated by the neural tissue resulting from the electric field stimulation by the at least one neural tissue stimulation device.

US Pat. No. 10,136,824

ARTERIAL SPIN LABELING (ASL) WITH MAGNETIC RESONANCE FINGERPRINTING (MRF)

Case Western Reserve Univ...

1. A method for performing arterial spin labeling (ASL) with magnetic resonance fingerprinting (MRF), comprising:selecting an ASL-MRF pulse sequence to apply to an object, where the ASL-MRF pulse sequence includes a labeling pulse and a control pulse;
controlling a magnetic resonance (MR) apparatus to apply the ASL-MRF pulse sequence to the object;
acquiring a nuclear magnetic resonance (NMR) signal evolution from the object, where the NMR signal evolution depends, at least in part, on a property of the arterial spins in the object;
selecting an entry in an MRF dictionary associated with the NMR signal evolution, and
simultaneously quantifying two or more properties of the arterial spins in the object based, at least in part, on the entry.

US Pat. No. 10,136,822

METHOD AND APPARATUS FOR NON-INVASIVELY DETECTING BLOOD VOLUME IMBALANCES IN A MAMMALIAN SUBJECT

Zynex Monitoring Solution...

1. An apparatus for noninvasively detecting blood volume changes in a mammalian subject, the apparatus comprising: a number of noninvasive sensors, communicable with the subject to obtain baseline and real time (current) physiologic value measurements from the subject; and at least one integrated circuit, operably connected with the sensors and configured to i) compute a real time (current) blood volume index from the physiologic value measurements wherein the blood volume index is derived from at least three physiological parameters selected from the group including heart rate, electrical body impedance, skin temperature, peripheral blood flow and skin humidity and wherein measurements of electrical body impedance, skin temperature, peripheral blood flow and skin humidity are taken at one or more extremities of the subject, and wherein the parameters are monitored by obtaining real time (current) value measurements for the parameters which are inputted into an algorithm which computes the real time (current) blood volume index based upon the differences between the baseline and real time (current) value measurements and wherein the algorithm includes coefficients for accurately weighting each parameter in the real time blood volume index, and wherein said algorithm for computing the real time (current) blood volume index=(100*(1?(((BINormalized?BIBaseline)/BIBaseline)*BICoefficient)?(((HRRealtime?HRBaseline)/HRBaseline*HRCoefficient)+(((PBFRealtime?PBFBaseline)/PBFBaseline*PBFCoefficient)?(((GSRRealtime?GSRBaseline)/GSRBaseline*GSRCoefficient)+(((STempRealtime?STempBaseline)/STempBaseline*STempCoefficient))) wherein BINormalized is peripheral bioimpedance normalized by removing known physiological drift, BICoefficient=0.725, HRCoefficient=0.145, PBFCoefficient=0.043, GSRCoefficient=0.014, and StempCoefficient=0.072, and ii) display the real time (current) blood volume index on a display of the apparatus, wherein the display is initially set to display a starting value blood volume index of 100 which indicates 100% of the subject's normal total blood volume, and wherein the displayed real time (current) blood volume index is capable of indicating a blood volume change in the subject as low as 10% of the subject's total blood volume.

US Pat. No. 10,136,821

IMAGE GENERATING APPARATUS, IMAGE GENERATING METHOD, AND PROGRAM

CANON KABUSHIKI KAISHA, ...

1. An apparatus for generating a photoacoustic image based on an acoustic wave caused by irradiation of light on an object, comprising:a determination unit configured to determine a propagation velocity of the acoustic wave; and
an image generation unit configured to generate the photoacoustic image based on the propagation velocity and a signal obtained by detecting the acoustic wave;
wherein the determination unit is configured to
set, based on an ultrasonic image obtained by transmitting and receiving an ultrasonic wave, a target position, and
determine, based on the signal corresponding to the target position, the propagation velocity.

US Pat. No. 10,136,820

METHOD TO VISUALIZE VERY EARLY STAGE NEOPLASM OR OTHER LESIONS

1. A treatment evaluation method comprisinganalyzing a liquid biopsy sample from a patient for the presence of at least one detectable biomarker of a lesion for which the patient has a family history of predisposition before there is any clinical manifestation or radiographic evidence of the lesion,
generating one or more anti-tumor antibodies based upon the at least one biomarker of the lesion detected in the liquid biopsy sample,
conjugating the one or more anti-tumor antibodies with nanoparticles to form functionalized antibody-coated nanoparticles,
administering, to the patient, the functionalized antibody-coated nanoparticles having a detectable property, the nanoparticles being further coated with a thermosensitive polymer coating,
heating the nanoparticles with an energy source to generate photoacoustic signals,
performing photoacoustic imaging with a photoacoustic imager to visualize any locally accumulated nanoparticles at a body site in the patient,
imaging the lesion at the site so as to determine the location of the lesion in or on the body of the patient by means of the locally accumulated nanoparticles, the lesion being otherwise radiographically undetectable absent the locally accumulated nanoparticles,
where the heating of the nanoparticles with the energy source further comprises heating the nanoparticles from a body temperature of 37° C. to a temperature between 40° C. and 43° C. to melt the thermosensitive polymer coating and release at least one of a medication, a gene together with a CRISPR/cas9 complex, or a checkpoint inhibitor from the nanoparticles,
treating the patient for the lesion by the release of the at least one medication, gene together with the CRISPR/cas9 complex, or checkpoint inhibitor from the nanoparticles locally at the location of the lesion, and
performing the method at least one time post-treatment to evaluate the treatment outcome quantifying the presence or absence of circulating cells or exosomes in the patient.

US Pat. No. 10,136,816

MEDICAL DEVICES AND METHODS

Abbott Diabetes Care Inc....

1. A system, comprising:an analyte sensor configured to be in fluid contact with bodily fluid under a skin surface;
sensor electronics including a memory, the sensor electronics operatively coupled to the analyte sensor to receive signals generated by the analyte sensor and to log data in the memory corresponding to the received signals generated by the analyte sensor, and further configured to detect a transmitted query; and
a display device configured for data communication with the sensor electronics, the display device comprising:
a storage device having stored therein one or more routines;
a processing unit operatively coupled to the storage device and configured to retrieve the stored one or more routines for execution;
a data transmission component operatively coupled to the processing unit and configured to transmit data based at least in part on the one or more routines executed by the processing unit; and
a data reception component operatively coupled to the processing unit and configured to receive analyte related data from the sensor electronics and to store the received analyte related data in the storage device;
wherein the data transmission component is programmed to transmit a query to the sensor electronics;
wherein the data reception component receives the analyte related data from the sensor electronics in response to the transmitted query when the sensor electronics transitions from a low power state to a fully operational state in response to detection of the query from the data transmission component by the sensor electronics; and
wherein the sensor electronics is configured to overwrite the logged data in the memory prior to an expiration of a life of the analyte sensor with new data corresponding to signals obtained from the analyte sensor after the expiration of the analyte sensor life, the sensor electronics configured to communicate to the data reception component of the display device the analyte related data that includes the logged data in the memory including the new data corresponding to the signals obtained from the analyte sensor after the expiration of the analyte sensor life.

US Pat. No. 10,136,814

AUTOMATIC PATHWAY AND WAYPOINT GENERATION AND NAVIGATION METHOD

COVIDIEN LP, Mansfield, ...

1. A method of providing a pathway from a starting point to a target location within a patient, comprising:selecting a target location within a patient;
using a processor to execute instructions stored on a non-transitory computer-readable storage medium to cause the processor to determine a pathway from a starting point to the target location by beginning at the target location and following back to the starting point, wherein determining the pathway includes assigning at least one waypoint along the pathway;
positioning a locatable guide at the starting point; and
advancing the locatable guide from the starting point to the target location following the determined pathway,
wherein determining the pathway further includes:
calculating an airway diameter along a path, as a candidate for the pathway, from the target to the starting point;
detecting a decrease in the airway diameter along the path; and
aborting the path if the decrease in the airway diameter is detected.

US Pat. No. 10,136,813

SYSTEMS AND METHODS FOR PATIENT CARDIOVASCULAR AND RESPIRATORY MANAGEMENT

1. A method for displaying integrated graphics for diagnostics for a patient's physiology, the method comprising:displaying a cardiac graphic object representing cardiac performance based on at least one measurement from the patient's left ventricle performance, said cardiac graphic object including at least a first, second, and third physiological parameter;
displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters;
displaying a pulmonary graphic object representing pulmonary performance, wherein displaying the pulmonary graphic object comprises displaying pulmonary vascular blood flow, and wherein the displaying the pulmonary vascular blood flow comprises displaying at least one measurement based on the patient's pulmonary arterial blood pressure and at least one measurement based on the patient's pulmonary venous blood pressure, and at least one measurement based on the patient's pulmonary vascular resistance; and
displaying a systemic vascular graphic object representing systemic cardiovascular performance, wherein displaying the systemic vascular graphic object comprises displaying systemic vascular blood flow, wherein the displaying the systemic vascular blood flow comprises displaying at least one measurement based on the patient's systemic arterial blood pressure and at least one measurement based on the patient's systemic venous blood pressure, and at least one measurement based on the patient's systemic vascular resistance.

US Pat. No. 10,136,810

SYSTEMS AND METHODS FOR DIAGNOSIS AND THERAPY OF VISION STABILITY DYSFUNCTION

NEUROSCIENCE RESEARCH AUS...

1. A device for obtaining vestibulo-ocular reflex data from a patient having a head and at least one eye, the device including:a frame configured for mounting to the patient;
a target module mounted to the frame and being responsive to a drive signal to project a selectively movable target object onto a surface in front of the patient;
an eye tracking module mounted to the frame, the module being adapted for obtaining first data indicative of one or more characteristics of the at least one eye; and
a head tracking module mounted to the frame, the head tracking module being adapted for obtaining second data indicative of one or more characteristics of the motion of the head.

US Pat. No. 10,136,808

OPTICAL COHERENCE TOMOGRAPHY AS A RAPID, ACCURATE, NON-CONTACT METHOD OF VISUALIZING THE PALISADES OF VOGT

1. A method of imaging palisades of Vogt comprising:imaging the palisades of Vogt via a non-contact in-vivo or ex-vivo process to acquire an image, wherein the imaging the palisades of Vogt via a non-contact in-vivo process to acquire the image comprises acquiring high-resolution images rapidly at a predetermined distance from a patient by directing laser light at a corneal limbus of the patient and measuring a delay caused by reflection of the laser light from the corneal limbus, wherein recognition of tissue boundaries depends on contrast between backscattered and/or reflected signal strength;
transferring the image to an analyzing component;
identifying in the analyzing component structures represented in the image to determine a status of the image;
and
storing the image in a data storage component for future evaluation or comparison.

US Pat. No. 10,136,806

IMAGE DISPLAY METHOD, IMAGE DISPLAY APPARATUS, AND STORAGE MEDIUM

Canon Kabushiki Kaisha, ...

1. An image display method comprising:acquiring a first image of a fundus within a first area of an eye to be inspected;
acquiring interference signal sets corresponding to a plurality of frames, which are acquired with an intention to acquire the same cross section, for a plurality of different cross sections;
generating, based on the interference signal sets corresponding to the plurality of frames, a motion contrast image of the fundus within a second area included in the first area; and
superimposing, for display, information acquired from a portion of the motion contrast image of the fundus onto a corresponding position of the first image of the fundus.

US Pat. No. 10,136,802

DEVICE FOR SUSTAINED RELEASE OF OPTICAL CLEARING AGENT, ENDOSCOPE HAVING THE SAME, AND INSTRUMENT FOR ENDOSCOPIC SURGERY HAVING THE SAME

OLYMPUS CORPORATION, Tok...

1. A method for achieving sustained release of optical clearing agent comprising:(a) inserting into a lumen a device for sustained release of optical clearing agent without inflating any of at least two pouch-shaped elastic components of the device, the device comprising:
a stick-shaped component inside which at least two supplying passages are formed for supplying gas or liquid and which has apertures of the respective supplying passages formed at positions in a vicinity of a top end of the stick-shaped component along a circumference of a lateral surface thereof,
the at least two pouch-shaped elastic components placed at positions in the vicinity of the top end of the stick-shaped component along the circumference of the lateral surface of the stick-shaped component to cover the respective apertures of the supplying passages respectively;
(b) moving the device for sustained release of optical clearing agent so that the top end of the stick-shaped component, where the pouch-shaped elastic components are provided, is positioned to a diseased region on a wall surface of the lumen;
(c) rotating the stick-shaped component via a rotary unit until a body-fluid absorbing component fixed on a surface of a first pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(d) infusing gas or liquid into the first pouch-shaped elastic component from the aperture of a first supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the first supplying passage, to inflate the first pouch-shaped elastic component;
(e) pressing the body-fluid absorbing component against the diseased region through deformation of the first pouch-shaped elastic component, to make the body-fluid absorbing component absorb body fluid on a surface of and from inside the diseased region;
(f) discharging the gas or fluid from inside the first pouch-shaped elastic component through the aperture of the first supplying passage, to deflate the first pouch-shaped elastic component and detach the body-fluid absorbing component from the diseased region;
(g) rotating the stick-shaped component via the rotary unit until an optical clearing agent holding component fixed on a surface of a second pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(h) infusing gas or liquid into the second pouch-shaped elastic component from the aperture of a second supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the second supplying passage, to inflate the second pouch-shaped elastic component; and
(i) pressing the optical clearing agent holding component against the diseased region through deformation of the second pouch-shaped elastic component, to establish sustained release of optical clearing agent held by the optical clearing agent holding component to the diseased region.

US Pat. No. 10,136,801

BENDING PORTION AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending portion in which a plurality of bending pieces are pivotably continuously provided, the bending portion comprising:a first bending piece and a second bending piece provided adjacent to each other;
the first bending piece comprising:
a circular convex portion comprising a peripheral portion having a circular arc shape;
a support portion extended along an axial line direction of the first bending piece from a circular convex portion and supporting the circular convex portion;
a pair of engaging concave portions provided so as to sandwich the circular convex portion and the support portion; and
a pair of distal-end-side contact portions respectively extended from the engaging concave portions in an opposite direction of the circular convex portion,
the pair of engaging concave portions each comprising:
a first inclined portion extended from the support portion in a direction to form an obtuse angle with the support portion;
a second inclined portion extended from the first inclined portion in a direction to form an obtuse angle with the first inclined portion; and
an inside portion that is bent in an obtuse angle with respect to the second inclined portion and extended along a concentric arc of the peripheral portion so as to be adjacent to the distal-end-side contact portion; and
the second bending piece comprising:
a circular concave portion comprising an inside portion having a circular arc shape configured to slide with respect to the peripheral portion, the circular concave portion being provided so as to be pivotable around the circular convex portion;
a pair of engaging convex portions provided so as to sandwich the circular concave portion; and
a pair of proximal-end-side contact portions respectively extended from the engaging convex portions in an opposite direction from the circular concave portion, the pair of proximal-end-side contact portions being configured to come into contact with the distal-end-side contact portions when the circular concave portion pivots around the circular convex portion,
the pair of engaging convex portions each comprising:
 a pair of pointed portions having a shape along the support portion, the first inclined portion, and the second inclined portion, one of the pair of pointed portions being placed at a back of the engaging concave portion to face the support portion, the first inclined portion, and the second inclined portion when the distal-end-side contact portions and the proximal-end-side contact portion contact with each other; and
 an outside portion that is bent in an obtuse angle with respect to the pointed portions and extended along a concentric arc of the inside portion so as to be adjacent to the proximal-end-side contact portion.

US Pat. No. 10,136,800

BENDING OPERATION DEVICE AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending operation device, comprising:a bending lever that is inclinably supported with respect to an operation section of an endoscope;
an arm part that is provided on the bending lever and includes a distal end displaceable in conjunction with inclination operation of the bending lever; and
an intermediate lever, wherein
the intermediate lever includes a fixed end and a free end that are set on both ends in a longitudinal direction of the intermediate lever, the fixed end being swingably supported with respect to the operation section via a fulcrum, the intermediate lever further includes a force point between the fixed end and the free end and a point of application at a position on the intermediate lever that is farther from the fulcrum than the force point and is closer to the free end than the force point, the force point being connected to the distal end of the arm part through an intermediate wire, the point of application being connected to a bending wire, and the bending wire bending a bending portion provided in an insertion section of the endoscope.

US Pat. No. 10,136,798

ENDOSCOPIC SYSTEM

OLYMPUS CORPORATION, Tok...

1. An endoscopic system comprising:an endoscope comprising:
an insertion portion configured to be inserted into a body, the insertion portion having a channel to insert a treatment instrument through the channel, and
an operation portion connected to the insertion portion, the operation portion including a grasping portion configured to be grasped by a surgeon and an operation lever rotatably provided in the operation portion, the operation lever including a catching portion that catches the treatment instrument, the operation lever being configured to move the treatment instrument while being held by the catching portion to transmit a force of operation by the surgeon to the treatment instrument; and
an assistant instrument which assists the movement of the treatment instrument, the assistant instrument comprising:
a flexible tube in which an insertion path is formed to insert the treatment instrument,
a coupling portion which connects one end of the flexible tube and the channel so that the channel communicates with the insertion path, and
a holding portion including a base body connected to an other end of the flexible tube, the holding portion further including an attachment instrument attached to the operation portion so that the base body is disposed on a side of the operation portion where the operation lever is disposed.

US Pat. No. 10,136,797

ENDOSCOPE WITH EXTERNAL DEVICE CONNECTOR

FUJIFILM Corporation, To...

1. An endoscope apparatus, comprisingan insertion part that is inserted into a body cavity of a subject;
an operating part that is connected to the insertion part;
a universal cord that extends from the operating part; and
a connector part that is provided at a terminal of the universal cord away from the insertion part and is connected to an external device and transmits and receives a light signal to and from the external device,
wherein the connector part comprises:
a hollow metal member having two openings that communicate with each other;
an optical semiconductor element that is fixed to one opening side of the hollow metal member so as to be capable of sealing the periphery of the one opening;
a lens that is provided on the other opening side of the hollow metal member; and
a first sealing member that fixes the lens to the hollow metal member and seals a gap between the lens and the hollow metal member.

US Pat. No. 10,136,796

MEDICAL DEVICE POSITIONING SYSTEM

Boston Scientific Scimed,...

1. A medical device, comprising:an insertion portion, including:
a proximal portion including a first engagement member, the first engagement member including one of:
(a) a helical groove that leads into a linear groove, and
(b) a pin,
wherein the proximal portion further includes a deflectable endoscope shaft,
a distal portion rotatably coupled to the proximal portion, the distal portion including:
a laterally-facing opening, and
a second engagement member, the second engagement member including the other of the helical groove and the pin, the pin being slidably received by the helical groove and by the linear groove, wherein:
the helical groove extends at least 360 degrees about at least one of the proximal portion and the distal portion,
a longitudinal axis of the linear groove extends parallel to a longitudinal axis of the insertion portion,
engagement between the helical groove and the pin allows rotation of the distal portion relative to the proximal portion through an angle up to at least 360 degrees, and
rotation of the distal portion is caused by sliding of the pin along and against the helical groove as the distal portion is forced in one of a proximal direction and a distal direction.

US Pat. No. 10,136,795

DISH RACK RETAINING CLIP

Whirlpool Corporation, B...

1. A dish rack assembly, comprising:a dish rack having spaced wire frame elements at least partially defining a dish rack side wall and configured to retain dishes;
a height adjuster comprising an arm located on an exterior of the dish rack side wall having a pair of spaced first ribs extending therefrom with each of the pair of spaced first ribs extending along a different wire frame element, the height adjust further including a lever and wherein the arm is configured to be operably coupled to a tub side wall and the lever is configured to move the arm vertically to adjust the height of the dish rack with respect to the tub side wall; and
a retaining clip located on an interior of the dish rack side wall and having a planar body with a pair of second ribs extending therefrom, each of the pair of second ribs is complementary to each of the pair of first ribs;
wherein the retaining clip is mounted to the arm such that a first of the pair of first ribs and a first of the pair of second ribs are directly adjacent opposite lateral sides of a first of the spaced wire frame elements and the arm and retaining clip are on opposite sides, transverse to the lateral sides, of the first of the spaced wire frame elements and a second of the pair of first ribs and a second of the pair of second ribs are directly adjacent opposite lateral sides of a second of the spaced wire frame elements and the arm and retaining clip are on opposite sides, transverse to the lateral sides, of the second of the spaced wire frame elements.

US Pat. No. 10,136,793

DISHWASHER

Whirlpool Corporation, B...

1. A dishwasher comprising:a tub having an open face and at least partially defining a treating chamber receiving dishes for treatment and having a tub air outlet located in an upper portion of the tub and a tub air inlet located in a lower portion of the tub;
a door assembly moveable between an opened position and a closed position where the door assembly closes the open face;
an airflow conduit extending along a portion of the tub and fluidly coupling the tub air outlet to ambient air;
a blower assembly forcing air to flow from the tub and through the tub air outlet into the airflow conduit;
a first reservoir associated with the airflow conduit and located vertically between the tub air outlet and tub air inlet, the first reservoir collecting liquid condensed from the air forced through the airflow conduit, the first reservoir having a liquid outlet at a nadir of the first reservoir and wherein the liquid outlet is fluidly coupled to an opening the tub via a liquid conduit for draining the collected liquid into the tub and wherein the opening in the tub comprises a water inlet for the tub, wherein the water inlet receives water from a household water supply; and
a second reservoir associated with the airflow conduit downstream of the first reservoir and collecting liquid condensed from the air prior to exhaustion of the air to the ambient air;
wherein any liquid not collected by the first reservoir is collected by the second reservoir for evaporation.
US Pat. No. 10,137,203

HER2 APTAMER-ANTICANCER DRUG COMPLEX FOR CANCER CELL CHEMOTHERAPY

Korea University Research...

1. A method of manufacturing a complex for cancer cell chemotherapy, comprising:a) preparing a nucleic acid aptamer consisting of the base sequence of SEQ ID NO:1 for specifically binding to HER2; and
b) forming an aptamer-anticancer drug complex by reacting the aptamer with anticancer drug DM1;
wherein the aptamer includes a thiol group introduced at the 3? terminal end and DM1 includes a thiol group such that a disulfide bond is formed between the aptamer and DM1.
US Pat. No. 10,138,486

INHIBITORS OF DEK PROTEIN AND RELATED METHODS

THE REGENTS OF THE UNIVER...

1. A method of treating or ameliorating an inflammatory condition in a patient, comprising administering to said patient a therapeutically effective amount of a single-stranded anti-DEK DNA aptamer, and a pharmaceutically acceptable carrier, wherein said anti-DEK DNA aptamer is SEQ ID NO:1, SEQ ID NO: 2 or SEQ ID NO:6.
US Pat. No. 10,138,490

TRANSFORMED PLANTS TOLERANT TO HERBICIDES DUE TO OVEREXPRESSION OF PREPHENATE DEHYDROGENASE AND P-HYDROXYPHENYLPYRUVATE DIOXYGENASE

1. A method for cultivating a transformed plant, the method comprisinga) planting a seed of the transformed plant,
b) contacting the seed or a transformed plant grown from the seed with a herbicidal composition comprising an inhibitor of p-hydroxyphenylpyruvate dioxygenase, and
c) cultivating the plant, wherein the transformed seed or the transformed plant is substantially unaffected by the herbicidal composition, wherein the plant comprises:
(1) a first gene that is functional in a plant, wherein the first gene comprises a nucleotide sequence that encodes a yeast prephenate dehydrogenase, and
(2) a second gene that is functional in a plant, wherein the second gene comprises a nucleotide sequence that encodes a p-hydroxyphenylpyruvate dioxygenase, and
wherein the plant overexpresses the prephenate dehydrogenase and the p-hydroxyphenylpyruvate dioxygenase, and wherein said plant is tolerant to an amount of said inhibitor that is toxic to or decreases the growth of plants transformed with said second gene alone.
US Pat. No. 10,137,215

ORGANIC WASTE ODOR ABSORBER

1. A method of treating organic waste comprising:a step of placing a composition within a receptacle to create a layer on the bottom of said receptacle;
a step of placing organic waste within said receptacle already containing the layer of said composition, where said organic waste is placed on top of said composition;
a step of placing additional said composition on top of said organic waste within said receptacle;wherein said composition's materials comprise:a. 35% to 85% holocellulose, by weight
b. 8% to 30% lignin, by weight
c. 40% to 80% silica, by weight;wherein said composition comprises dried materials;wherein said composition's materials comprise a particle size range from 0.002 millimeters in diameter to 300 by 300 by 300 millimeters;wherein said composition comprises a scent;wherein said organic waste is composted.
US Pat. No. 10,137,475

COATING SYSTEM, A METHOD OF APPLYING THE COATING SYSTEM AND AN ARTICLE COMPRISING THE COATING SYSTEM

Dow Global Technologies L...

1. A method of applying a multi-layer coating system comprising:(I) selecting an epoxy formulation which comprises
(a1) epoxy resin;
(a2) curing agent selected from the group consisting of amine adducts, amides, polyamides, and Mannich bases derived from polyfunctional amines with no more than 4.5 wt % free amine based on a weight solids of the curing agent; and
(II) applying the epoxy formulation onto a substrate;
(III) fully or partially curing the epoxy formulation to produce an epoxy coating layer;
(IV) selecting a non-isocyanate polyurethane formulation;
(V) applying the non-isocyanate polyurethane formulation onto the epoxy coating layer; and
(VI) allowing the topcoat formulation and epoxy formulation to fully cure thereby forming a multi-layer coating system;
wherein the epoxy formulation and/or non-isocyanate polyurethane formulation optionally further comprise one or more additives selected from the group consisting of solvent, reactive diluent, plasticizer, pigment, filler; rheology modifiers, dispersants, surfactants, UV stabilizers, and corrosion inhibitors.
US Pat. No. 10,138,500

D-LACTIC ACID-PRODUCING STRAIN AND USE THEREOF

CJ CHEIJEDANG CORPORATION...

1. A D-lactic acid-producing strain modified to attenuate or inactivate L-lactate dehydrogenase (L-LDH) activity and to enhance D-lactate dehydrogenase (D-LDH) activity, wherein the D-lactic acid-producing strain so modified is a Lactobacillus sp strain which produces more L-lactic acid than D-lactic acid prior to said modification; wherein the L-LDH activity is derived from a L-LDH-encoding polynucleotide from Lactobacillus paracasei, Lactobacillus casei, or Lactobacillus rhamnosus; wherein the D-LDH activity is derived from a D-LDH-encoding polynucleotide from Lactobacillus plantarum or Lactobacillus delbrueckii; and wherein the Lactobacillus sp. strain is selected from the group consisting of Lactobacillus casei, Lactobacillus paracasei, and Lactobacillus rhamnosus.
US Pat. No. 10,136,708

LIGHT PRECIOUS ALLOY OF GOLD AND TITANIUM AND COMPONENTS FOR TIMEPIECES OR JEWELLERY MADE FROM SUCH A LIGHT PRECIOUS ALLOY OF GOLD AND TITANIUM

1. A light, precious gold-titanium based alloy comprising, by mass, from 750‰ to 780‰ of gold,wherein said alloy has the following composition formula:
TiaAubMcTd
where a b, c, d are atomic proportions such that:
a+b+c+d=1,
0.45?a?0.55; 0.41?b?0.495; 0.025?c?0.13; 0.001?d?0.025,
wherein M represents at least one element selected from the group consisting of Nb, V, Pd, Pt, and Fe, and
T represents boron and optionally an additional element, and
wherein the additional element is selected from the group consisting of Nb, V, Pd, Pt, Fe, Mo, Ta, W, Co, Ni, Ru, Rh, Ir, Cr, Mn, Cu, Zn, Ag, Al, Si, Ge, Sn, Sb, and In,
M and T are different elements, and
the alloy comprises the boron as T or as a part of T in an atomic content of from 0.03% to 0.3%.
US Pat. No. 10,138,501

METHOD FOR PREPARING DIGLYCERIDE USING BUBBLE COLUMN REACTOR

Jinan University, Guangz...

1. A method for synthesizing diglyceride using a bubble column reactor, characterized by comprising the steps of:(1) placing an immobilized enzyme on the bearing mechanism of the bubble column reactor, and a hot bath mechanism is actuated to heat the reactor body to 55-75° C.;
(2) adding glycerol and fatty acid in a feed chute as reactants, and water is added as an activating enzyme catalyst; wherein the molar ratio of glycerol and fatty acid is 1:1-10:1; the added amount of water is less than 10% of the total mass of the reactants; and the added amount of the immobilized enzyme in step (1) is 1-10% of the total mass of the reactants;
(3) preheating glycerin, fatty acids and water in the feed chute to 55-75° C., then charged into the reactor body to initiate a synthesis reaction; a blowing mechanism is actuated and the flow rate of an inert gas is controlled at 0.7-5.7 cm/s, so that the inert gas is continuously blown into the reactor body via a sieve plate, forming boiling bubbles;
(4) turning off the hot bath mechanism and the blowing mechanism after the synthesis reaction is carried out for 15-90 min, stopping the heating and the inert gas circulation, actuating a compacting mechanism, and standing and layering the reaction mixture, thus obtaining an upper layer, which is a crude glycerin layer, and a lower layer, which is a glycerol layer; the crude glycerin layer is removed off the free fatty acids via a first-stage molecular distillation, then sent into a second-stage molecular distillation, thus obtaining a distillate and a distillation residue; wherein the distillate is high purity diglyceride, and the distillation residue is monoglyceride;
wherein the bubble column reactor in step (1) comprises a reactor body, a bearing mechanism, a sieve plate, a compacting mechanism, a blowing mechanism, a hot bath mechanism, a feed chute, and a connecting cylinder, wherein the reactor body, the bearing mechanism and the connecting cylinder are connected sequentially from top to bottom; the hot bath mechanism, the reactor body, and feed chute are sequentially connected, and formed a hot bath circulation; the reactor body is communicated with the connecting cylinder, the connecting cylinder is connected to the blowing mechanism, the sieve plate is placed on the upper end of the connecting cylinder, the compacting mechanism is mounted on the connecting cylinder, the upper end of the compacting mechanism is inserted into the connecting cylinder, and the upper end of the compacting mechanism is abutted against the sieve plate;
wherein the compacting mechanism comprises a floating joint, a cylinder, a compacting head, wherein the piston rod of the cylinder is connected to the compacting head via the floating joint, the compacting head is abutted against the sieve plate; the upper end of the compacting head is provided with a first upper cavity, the first upper cavity is communicated with the internal cavity of the reactor body via the sieve plate, the bottom surface of the first upper cavity is arranged in an inclined mode; the lower end of the compacting head is provided with a first lower cavity, the floating joint is connected to the first lower cavity; the side wall of the upper end of the compacting head is provided with a first through hole, the first through hole is communicated with the first upper cavity and the internal cavity of the connecting cylinder; and
wherein the internal cavity of the connecting cylinder is provided with flow-guiding plate, the internal cavity of the connecting cylinder is divided into a second upper cavity and the second upper cavity by the flow-guiding plate, the second upper cavity is communicated with the internal cavity of the reactor body, the flow-guiding plate is arranged in an inclined mode, the middle of the flow-guiding plate is provided with a second through hole through which the piston rod of the cylinder passes, the floating joint is sleeved with a sealing sleeve, the sealing sleeve is closely connected to the second through hole; the connecting cylinder is provided with a gas ventilating hole and a liquid collecting hole, both the gas ventilating hole and the liquid collecting hole are communicated with the second upper cavity, the gas ventilating hole is connected to the blowing mechanism; the axis of the liquid collecting hole is arranged in parallel with the flow-guiding plate, and the lower end of the flow-guiding plate is at the same height as that of the lower edge of the liquid collecting hole.