US Pat. No. 10,137,051

SINGLE TUBE CRUTCH AND METHOD OF NESTING AND PACKAGING THE SAME

Medline Industries, Inc.,...

1. A crutch, comprising:a single tube support comprising an upper leg and a lower leg comprising a slip-resistant tip, the lower leg fully insertable into a first end of the upper leg such that only the slip-resistant tip is exposed;
an underarm support coupled to a second end of the upper leg opposite the first end;
a grip assembly configured to translate along the upper leg between a usage position and a stowed position, the grip assembly comprising an annular receiver and a grip extending distally from the annular receiver;
a plurality of grip assembly apertures disposed along the upper leg, each of which the grip assembly may align when in the usage position; and
a stowage aperture disposed along the upper leg, with which the grip assembly may align when in the stowed position.

US Pat. No. 10,137,048

STRETCHING APPARATUS FOR STRETCHING THE BACK

1. A stretching appliance, comprising:a floor plate (9) having a mast (6, 8) upwardly disposed on said floor plate (9) and having an adjustable height;
a rest mounted on said mast and being configured for supporting a human body, said rest is pivotably mounted to said mast (6, 8) and is being configured to pivot about a horizontal axis (42);
shoulders restraining means adjustably mounted on a first end of said rest and being configured to hold shoulders of a human body laying on said rest;
feet restraining means adjustably mounted on a second end of said rest and being configured to hold feet of the human body laying on said rest; and
an adjusting mechanism configured for adjusting distance between said shoulder restraining means and feet restraining means by way of pivoting the rest about the horizontal axis.

US Pat. No. 10,137,047

AUTOMATED PILOTLESS AIR AMBULANCE

1. An automated pilotless air ambulance system comprising:an air vehicle (AV) having a fuselage, the fuselage having a stretcher mounted thereon for carrying a patient, the air vehicle configured to be dispatched to a point of injury of the patient and further configured to transport the patient to a medical treatment facility;
a plurality of air-lift motors coupled to the fuselage for vertically lifting the air vehicle, each air lift motor being coupled to a mounting arm such that the air lift motors are disposed substantially in the front and back of the fuselage, thereby enabling the stretcher to be transported with the patient thereon into and out of the AV, and wherein each mounting arm is securely coupled to the fuselage to form a low-profile configuration, whereby the patient is nested in the AV such that each air lift motor is disposed substantially on the same plane as the patient;
an automated life support and monitoring patient suite having a plurality of life support and monitoring devices and medical supplies; and
a bidirectional datalink coupled to the air vehicle, the datalink configured to execute the following functions:
receive and send signals to a patient's or first responder's mobile device or a networked device having geolocation capabilities, thereby enabling the air vehicle to obtain a geographic earth location of the patient;
receive and send signals to the patient's or first responder's mobile device for allowing the air vehicle to be autonomously dispatched when contacted by the patient's or the first responder's mobile device or the networked device;
receive and send signals to at least one medical health provider or physician who is using another air vehicle (AV) system to provide guidance to the first responder; and
receive and send signals to the at least one medical health provider or physician in order to allow the at least one medical health provider or physician to monitor the patient's vitals and to prepare the medical treatment facility for the patient's arrival.

US Pat. No. 10,137,046

DISPOSABLE BEDPAN WITH LID

1. A disposable bedpan with lid, comprising:A) a bedpan comprising a base and a sidewall having at least one lateral support, said bedpan further comprises a top ridge and a front ridge, said bedpan further comprises a front top cavity defined between said top ridge and said front ridge;
B) a cover comprising a cover base and a u-shaped cover base ridge, said u-shaped cover base ridge is inserted into said front top cavity when said cover mounts upon said bedpan, said cover is connected to said bedpan by a hinge; and
C) a lid comprising a lid panel, said lid is connected to said bedpan by a lid hinge, said lid further comprises at least one panel locking protrusion that secures upon said cover when in a closed configuration, said cover and said lid seal said bedpan to prevent waste from coming out when in said closed configuration, said lid panel comprising at least one lid ridge.

US Pat. No. 10,137,044

PATIENT SUPPORT APPARATUS WITH SENSOR ASSEMBLY

Hill-Rom Services, Inc., ...

1. A patient support system, comprising:a patient support device including an air fluidizable section, the air fluidizable section including a basin containing fluidization material for creating a two-phase support surface for patient support by distribution of pressurized fluid through the fluidization material, and
a sensor assembly configured to detect a temperature within the air fluidizable section, the sensor assembly comprising:
a housing defining an interior space, the housing being coupled to a wall of the air fluidizable section,
a processor, the processor being positioned within the interior space of the housing,
a thermal conductor, and
a thermal insulator.

US Pat. No. 10,137,040

ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. An absorbent article having a wearer-facing side and a garment-facing side, and extending in a longitudinal direction and a transversal direction, the article comprising:a topsheet on the wearer-facing side for contact with a wearer's skin;
a backsheet on the garment-facing side;
an absorbent core between the topsheet and the backsheet, wherein the absorbent core comprises an absorbent material layer, the absorbent material layer comprising an absorbent material and further comprising a longitudinally-extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;
wherein the absorbent core further comprises a first folding guide dividing the central portion and the first side portion, and a second folding guide dividing the central portion and the second side portion;
wherein the central portion and the side portions form a three-dimensional basin when the absorbent core is folded along the folding guides;
wherein the absorbent article further comprises:
at least one liquid management layer substantially free of superabsorbent polymer, the liquid management layer being at least partially disposed between the topsheet and the absorbent core; and wherein the liquid management layer comprises a liquid management layer's central portion, a first and second liquid management layer's side portions, and a first and second liquid management layer's folding guides between the liquid management layer's central portion and the first and second liquid management layer's side portions respectively, wherein the liquid management layer's folding guides are at least partially superposed with the folding guides of the absorbent core; and wherein each side portion comprises a plurality of winglets arranged in the longitudinal direction, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, wherein neighboring winglets are separated by a gap between their neighboring sides.

US Pat. No. 10,137,039

ABSORBENT CORES HAVING CHANNEL-FORMING AREAS AND C-WRAP SEALS

1. A absorbent core extending in a transversal direction and a longitudinal direction, the absorbent core having a front edge, a back edge and two longitudinally extending side edges, the absorbent core comprising:(a) a core wrap comprising a first substrate and a second substrate wherein each substrate comprises an inner surface and an outer surface;
(b) an absorbent material comprising a periphery defining an absorbent material deposition area, between the first substrate and the second substrate, the absorbent material deposition area encompassing one or more areas substantially free of absorbent material; and
(c) an auxiliary glue applied directly to the inner surface of the first substrate and defining an auxiliary glue application area;
wherein the auxiliary glue at least partially bonds the inner surface of the first substrate to the inner surface of the second substrate through the one or more areas substantially free of absorbent material, so that when the absorbent material swells, the core wrap forms channels in the areas substantially free of absorbent material that have a width from 2 mm to 20 mm;
wherein the auxiliary glue application area is smaller than the absorbent material deposition area and the first substrate and/or the second substrate comprises at least one outwardly extending flap which is folded around at least one of the front, back, or any of the side edges of the core, and the at least one flap is bonded to the external surface of the other substrate to form a C-wrap seal along the at least one edge of the absorbent core; and
wherein the channels do not extend to any edge of the absorbent material deposition area.

US Pat. No. 10,137,038

STERILE ADHESIVE BANDAGE CONTAINING A POCKET

1. An adhesive bandage comprising a base portion having at least one gauze portion adapted to contact a wound in a skin surface and an adhesive portion; the adhesive portion having an adhesive on a first surface of the base portion adapted to adhere to skin around three sides of and peripheral to the wound; the base portion defining a pocket adapted for storing the at least one gauze portion, wherein the pocket comprises a folded over flap of the base portion and a side opening of the pocket allowing inspection and replacement of the at least one gauze portion without having to remove the entire bandage.

US Pat. No. 10,137,036

UNDERWATER MASK

TABATA CO., LTD., Tokyo ...

1. An underwater mask having an up-down direction and a lateral direction, comprising: a mask body having opposing sides and which comprises a lens frame having a lens on a front; a skirt extending rearward from the lens frame; and a strap configured to be coupled to at least one of the opposing sides of the mask body through a buckle, the strap having a plurality of engaging teeth, the buckle comprising: a base; a strap adjuster body; a handling member; and a stopper, the base comprising: a second coupling portion configured to be coupled to a first coupling portion on the at least one of the opposing sides turnably in the lateral direction; a fitting hole; and a spring comprising a locking hook, the strap adjuster body comprising: a plurality of engaging teeth opposite the spring configured to sequentially engage with the locking hook; a fitting shaft configured to be fitted into the fitting hole turnably by a predetermined angle in a circumferential direction of the fitting shaft; a guide shaft configured to be wound by the strap; a slide guide groove extending in the up-down direction; and a pair of guide openings opposite to each other in the up-down direction, the handling member comprising: an approximately V-shaped spring; a slider configured to slide along the slide guide groove; a pair of sliding portions near the slider; and a finger pad outside each sliding portion of the pair of sliding-portions, the finger pads configured to be exposed from the guide openings of the strap adjuster body, the stopper comprising: a pawl configured to sequentially engage with the engaging teeth of the strap; and a sliding contact tapered protrusion near the pawl, the sliding contact tapered protrusion slidably disposed between the pair of sliding portions, wherein the stopper is configured to be held by the strap adjuster body swingably toward a direction opposite to the body.

US Pat. No. 10,137,034

PRESSURE-SENSING VITRECTOMY SURGICAL SYSTEMS AND METHODS

Novartis AG, Basel (CH)

1. A system for providing irrigation into an eye of a patient during a medical procedure, the system comprising:an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including:
a flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient;
an engagement member at the distal end, the engagement member being more rigid than the flexible elongate member and being configured to enter into a vitreous chamber of the eye of the patient; and
at least three pressure sensors internally disposed in the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential associated with a flow impediment along the infusion line between two of the at least three pressure sensors, such that the flow impediment is locatable between the two pressure sensors associated with the flow impediment pressure differential.

US Pat. No. 10,137,032

SLUSH GENERATION

42 TECHNOLOGY LIMITED, C...

1. An apparatus for generating, at a target ice/liquid ratio with a corresponding target temperature, a slush comprising a frozen and non-frozen liquid, the apparatus comprising:a flow path that recirculates the frozen and non-frozen liquid therethrough; and
a heat exchanger, forming part of the flow path, comprising a coolant conduit extending longitudinally through the heat exchanger and a freeze conduit extending longitudinally through the heat exchanger, wherein the coolant conduit and the freeze conduit share a contiguous boundary along their longitudinal length through the heat exchanger such that thermal energy is transferred between the freeze conduit and the coolant conduit to partially freeze the non-frozen liquid in the conduit loop to generate the slush at the target ice/liquid ratio;
wherein the freeze conduit is devoid of an ice scraper and the coolant conduit is configured for flow therethrough of coolant at a temperature below the target temperature, the apparatus being configured to vary the rate of coolant flow through the coolant conduit between a first rate and a second rate that is lower than the first rate.

US Pat. No. 10,137,030

SELF-TITRATABLE MANDIBULAR REPOSITIONING DEVICE

Sleep Science Partners, I...

1. A mandibular re-positioning device, comprising:a first component adapted to receive a user's top teeth and a second component adapted to receive the user's bottom teeth and an intermediate component adapted to fit between the upper component and the lower component and to couple the upper and lower components;
a first mechanism coupling together the upper component with the intermediate component;
the first mechanism coupling the upper and intermediate components in either of two states comprising an unlocked state or a locked state;
the unlocked state allowing the upper and intermediate components to slide, relative to each other, along a sagittal axis, thereby allowing the user's mandible to freely move in an anterior or posterior direction while the mandibular re-positioning device is positioned within the user's mouth;
the locked state bringing the first component into closer contact with the intermediate component, thereby preventing the two components from sliding, relative to each other, along the sagittal axis, thereby preventing any change in mandibular advancement while the mandibular re-positioning device is positioned within the user's mouth;
the first mechanism being able to transition from the unlocked state to the locked state through application of a force along a vertical axis, the force coming from the user biting down;
a second mechanism coupling together the intermediate component with the second component and adapted to allow movement of the user's mandible in a lateral direction while the mandibular re-positioning device is positioned within the user's mouth; and
the second mechanism including a groove along the lateral direction within the second component, the groove coupling to a rail or to a tab on the intermediate component that travels within the groove, the groove being curved within the second component to match a natural movement of the user's mandible.

US Pat. No. 10,137,028

EYEWEAR SYSTEM FOR SECURING LENS ON A USER'S NOSE AND DILATING USER'S NOSE

1. A device for coupling at least one eyewear lens to at least one nasal applique attachable to a user's nose which results in dilation of a nasal passageway, the device comprising:a base engageable with the at least one eyewear lens;
an adjustment shaft coupled to the base and extending longitudinally along a rotation axis, the adjustment shaft being rotatable relative to the base about the rotation axis;
a first pivot unit coupled to the base and pivotable relative to the base about a first pivot axis in response to rotation of the adjustment shaft about the rotation axis; and
a second pivot unit coupled to the base and pivotable relative to the base about a second pivot axis in response to rotation of the adjustment shaft about the rotation axis;
the first pivot unit and the second pivot unit being interactable with at least one nasal applique to magnetically couple the first pivot unit and the second pivot unit to the at least one nasal applique, the magnetic coupling between the first pivot unit and the second pivot unit and the at least one nasal applique imparting a dilating force on the user's nose to dilate the nasal passageway when the at least one nasal applique is attached to the user's nose.

US Pat. No. 10,137,027

NASAL APPLIQUE AND RELATED APPLICATOR FOR APPLYING APPLIQUE TO A NOSE OF A WEARER

1. An applicator for placing a pair of nasal appliques on opposing lateral regions of a nose of a user, the applicator comprising:a base;
a nose rest coupled to the base and adapted to rest adjacent the nose of the user;
a pair of stop members coupled to the base and arranged in generally opposed relation to each other; and
a pair of placement members coupled to the base, each placement member including an arm coupled to the base and a pad coupled to the arm, each placement member being engageable with a respective one of the pair of nasal appliques, each placement member being selectively transitional between a first position and a second position, when each placement member is in its first position, the placement member is positioned adjacent the respective one of the pair of stop members and when each placement member is in its second position, the placement member is moved away from the respective one of the pair of stop members for placing the respective one of the pair of nasal appliques on the nose of the user.

US Pat. No. 10,137,025

DEVICE AND METHOD FOR ELECTRIC STIMULATION OF MUSCLES INVOLVED IN HUMAN PHYSIOLOGICAL GAIT PATTERN AND BRACE TO SUPPORT AN ANATOMICAL JOINT WITH SUCH DEVICE

EVOMOTION GMBH, Luenebur...

5. A device for electrical stimulation of muscles involved in the physiological gait of a human, comprising: an element for electrical muscle stimulation; a sensor to detect information relevant to the muscle stimulation, wherein the sensor comprises a single gyroscope constructed to detect information including an angular speed ? and a swing direction in an extension direction and flexion direction of an anatomical lower leg of the human; an evaluation unit including a microprocessor to evaluate the information detected by the gyroscope and to determine a defined switching time for the muscle stimulation on the basis of the angular speed ? and the swing direction, and to transmit the determined switching time; and a control and regulation unit to trigger muscle stimulation by said element in response to receipt of the determined switching time.

US Pat. No. 10,137,024

APPARATUS, SYSTEM, AND METHOD FOR CONTROLLING MOVEMENT OF AN ORTHOPEDIC JOINT PROSTHESIS IN A MAMMALIAN SUBJECT

Elwha LLC, Bellevue, WA ...

1. A method for preventing dislocation of an orthopedic joint prosthesis in a mammalian subject comprising:providing an orthopedic brace external to the subject's body and including a first member and a second member, wherein the first member is configured to control movement of a first component of an internal orthopedic joint prosthesis and the second member is configured to control movement of a second component of the internal orthopedic joint prosthesis in the subject;
detecting one or more alignment orientations of the first component relative to the second component by one or more sensors in proximity to the first component and the second component of the internal orthopedic joint prosthesis, wherein the one or more sensors contact the internal orthopedic joint prosthesis;
communicating the one or more alignment orientations from the one or more sensors to one or more controllers; and
adjusting an alignment of the first component relative to the second component of the internal orthopedic joint prosthesis in response to a signal from the one or more controllers in operation with the first member and the second member of the orthopedic brace external to the subject's body.

US Pat. No. 10,137,023

COLONNADE (TM) EXPANDABLE INTRAGASTRIC FOOD FLOW LUMEN DEVICE

Medibotics LLC, St. Paul...

1. An implantable expandable intragastric device for reducing food consumption and/or absorption comprising:a plurality of longitudinal expandable members, wherein these expandable members are configured to be inserted into and expanded within a person's stomach, wherein these expandable members are expanded by being filled with one or more flowable substances selected from the group consisting of a gas, a liquid, a gel, and a foam, wherein each expandable member has a proximal surface which is configured to be closer to the gastroesophageal junction, wherein each expandable member has a distal surface which is configured to be closer to the pylorus, and wherein each expandable member has a central axis which spans from its proximal surface to its distal surface, wherein the expandable members have lateral cross sections that are shaped like keystones or rounded trapezoids, and wherein first portions of walls of the expandable members that are closer to a food flow lumen are less elastic than second portions of the walls of the expandable members that are farther from the food flow lumen;
the food flow lumen, wherein this food flow lumen has a proximal opening which is configured to be closer to the gastroesophageal junction, wherein this food flow lumen has a distal opening which is configured to be closer to the pylorus, wherein food flows into the proximal opening and out of the distal opening, wherein this food flow lumen has a central axis which spans from its proximal opening to its distal opening, wherein there is at least one plane of this device which is intersected by the central axis of the food flow lumen and the central axes of the expandable members, wherein the points where the central axes of the expandable members intersect this plane can be geometrically connected to form a polygon, wherein the point where the central axis of the food flow lumen intersects this plane is located inside this polygon, and wherein the expandable members are arranged symmetrically around the food flow lumen in a first cross-sectional plane and in a second cross-sectional plane, but are arranged asymmetrically around the food flow lumen in a third cross-sectional plane which is in between the first and second cross-sectional planes.

US Pat. No. 10,137,021

METHOD AND APPARATUS FOR CONTROLLING THE DEPLOYMENT OF A STENT

VASCUTEK LIMITED, Renfre...

1. A delivery apparatus, the apparatus comprising:a delivery shaft with a tubular prosthesis mounted on a proximal end thereof for insertion into a lumen and a distal end remote from the proximal end, the prosthesis comprising a sleeve and at least one discrete saddle-shaped ring stent with opposing peaks and opposing valleys positioned between the peaks, the at least one discrete saddle-shaped ring stent is attached to the sleeve to maintain the patency of the sleeve after deployment of the prosthesis;
a retractable sleeve adapted to contain the tubular prosthesis mounted on the delivery shaft;
a control handle adjacent the distal end of the delivery shaft;
at least one stent peak control wire extending from the control handle and directly attached to at least one peak of the opposing peaks at an at least one peak connection point;
at least one peak controller at the control handle adapted to control the position of the at least one stent peak control wire to selectively open the at least one peak from a collapsed state and collapse the at least one peak from an open state;
at least one stent valley control wire extending from the control handle and directly attached to at least one valley of the opposing valleys at an at least one valley connection point; and
at least one valley controller at the control handle adapted to control the position of the at least one stent valley control wire to selectively open the at least one valley from a collapsed state and collapse the at least one valley from an open state.

US Pat. No. 10,137,019

MEDICAL INSTRUMENT, RING PROSTHESIS, STENT AND STENTED VALVE

DAIDALOS SOLUTIONS B.V., ...

1. A stent, comprising:a tubular element with an open grid structure which is radially expandable from a compressed condition to an expanded condition, and which has a proximal and distal end; and
a ring structure provided around the tubular element,
wherein the tubular element and ring structure are interconnected,
wherein the ring structure is a variable-diameter ring structure with distal and proximal flange feet,
wherein the ring structure has an axial direction and a radial direction disposed transverse to the axial direction,
wherein the ring structure is constructed from a series of elongated closed loops lying next to one another which, in each case, at the midpoint of the longitudinal sides of the loops, are attached laterally to one another via a junction to form the ring structure, in such a way that a) an imaginary center line through all junctions forms a closed ring and divides each loop into a distal flange foot of said distal flange feet and a proximal flange foot of said proximal flange feet, and b) the ring structure is expandable,
wherein the distal and proximal flange feet each have a fixed end arranged at the imaginary center line and a free end pointing away from the imaginary center line,
wherein the distal and proximal flange feet have a radial position, in which the free ends of the flange feet point in the radial direction,
wherein the distal and proximal flange feet have an extended position, in which the distal and proximal flange feet extend in the axial direction,
wherein the distal flange feet and the proximal flange feet lie in a longitudinal direction of the tubular element when the tubular element is in the compressed condition and the distal and proximal flange feet are in the extended position,
wherein the distal and proximal flange feet, when in the extended position, are under a pre-tension, which, upon release, bends the distal and proximal flange feet from the extended position to the radial position,
wherein, in the extended position, the free ends of the distal flange feet point in the distal direction whilst the free ends of the proximal flange feet point in the proximal direction such that, after the distal and proximal flange feet have bent from the extended position to the radial position, the distal and proximal flange feet interact to clamp surrounding tissue between the distal and proximal flange feet, and
wherein the distal flange feet, at the fixed ends of the distal flange feet, have a concave-curved part including a hollow side facing toward the proximal flange feet, and in the hollow side of the concave-curved part, a filling is provided that is configured to increase a clamping force with which the distal and proximal flange feet clamp the tissue in situ when the distal and proximal flange feet are in the radial position.

US Pat. No. 10,137,018

ENDOVASCULAR ROUTER DEVICE AND METHOD

1. A router device for repairing a tubular vessel of a patient, where the tubular vessel is joined to at least one branch vessel, the router device comprising:a) a single wall and skeleton-free tubular graft having a proximal end and a distal end and at least one unobstructed fenestration formed therein before deployment in the patient, said fenestration adapted to receive and affix a stent, and a malleable annulus formed in a side of said tubular graft wherein the inner diameter of the annulus defines the fenestration and where the annulus inner diameter when deformed has a portion adjacent to the stent with a greater width than the outer diameter of the annulus and said fenestration sized and positioned to generally align with the branch vessel;
b) said distal end of the tubular graft having a diameter less than a diameter of the proximal end, and said single wall of the tubular graft including a tapered portion between the proximal and distal ends, wherein said fenestration is positioned within the tapered portion;
c) a cylindrical element including an outer surface that is adapted to be juxtaposed circumferentially to an interior surface of the tubular vessel so as to releasably affix the proximal end of the tubular graft to an interior surface of the tubular vessel so that the tubular graft may be repositioned within the tubular vessel of the patient; and
d) said distal end of the tubular graft configured so as to be suspended within an aneurysm formed in the tubular vessel when the proximal end of the tubular graft is affixed to the interior surface of the tubular vessel by the cylindrical element.

US Pat. No. 10,137,011

POWERED ANKLE-FOOT PROSTHESIS

Massachusetts Institute o...

1. An autonomous, wearable powered leg device, comprising:a) a controllable powered actuator including a motor being linkable to an ankle joint to thereby impart torque about the ankle joint;
b) a controller that includes an electromyographic processing unit linked to the controllable powered actuator;
c) at least one electromyographic sensor coupled to the electromyographic processing unit and connectable to limb muscles of an individual wearing the device, whereby electromyographic signals measured from the limb muscles are transmitted to the electromyographic processing unit and thereby modulate control commands from the controller; and
d) a plurality of servo controllers, at least one of the servo controllers linking the electromyographic processing unit to the controllable powered actuator, whereby the individual wearing the device can modulate the controller to adjust between the plurality of the servo controllers, wherein the servo controllers include:
i) a torque controller that provides an offset torque during powered plantar flexion push-off of the powered leg device;
ii) an impedance controller that modulates at least one of joint stiffness and damping of the powered leg device during a stance phase of a gait of the individual; and
iii) a position controller that controls foot position of the powered leg device during a swing phase of the gait of the individual.

US Pat. No. 10,137,010

COORDINATING OPERATION OF MULTIPLE LOWER LIMB DEVICES

VANDERBILT UNIVERSITY, N...

1. A method for operating an autonomous powered leg prosthesis for a lower limb of a body having at least one powered joint, at least one sensor for collecting real-time sensor information for the autonomous powered leg prosthesis, and a communications device, the method comprising:generating, via a first control system of the autonomous leg prosthesis, first control data for the communications device to establish a communications link with a second leg prosthesis associated with another lower limb of the body contralateral to the lower limb and having a second control system operating independently of the first control system;
receiving, at the first control system over the communications link, remote data for the second leg prosthesis, the remote data comprising state information for a second finite state model used by the second control system for operating the second leg prosthesis;
generating, via the first control system, second control data for transitioning the autonomous leg prosthesis from a current state in a first finite state model for operating the autonomous powered leg prosthesis to a different state in the first finite state model,
wherein the different state is selected based on the real-time sensor information and the remote data, wherein at least one state in the first finite state model is configured for causing the at least one powered joint to deliver net power, wherein the second control data further comprises instructions to transition the autonomous leg prosthesis to the at least one state only if the state data in the remote data indicates that the second leg prosthesis is in a weight bearing state.

US Pat. No. 10,137,007

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion;
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion; and
at least one spike pivotally attached to at least one of the first and second spaced apart walls of the yoke;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke;
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position; and
wherein the linear motion of the yoke is translated to pivotal motion of the at least one spike from a collapsed position, to a fully deployed position transverse to the mid-longitudinal axis.

US Pat. No. 10,137,006

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween, the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion; and
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke; and
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position.

US Pat. No. 10,137,005

DEVICE AND METHOD FOR DEPLOYMENT OF AN ANCHORING DEVICE FOR INTERVERTEBRAL SPINAL FUSION

Globus Medical, Inc., Au...

1. An intervertebral fusion device comprising:a spacer adapted to be implanted between an upper vertebral body and a lower vertebral body;
a first anchor and a second anchor positioned within the spacer; and
an actuation screw positioned within the spacer and adapted to engage with the first anchor and the second anchor,
wherein when the actuation screw is actuated in a first direction, the first anchor moves to engage the upper vertebral body and the second anchor moves to engage the lower vertebral body, wherein the first anchor and the second anchor are configured to be moved simultaneously, and
wherein each of the first and second anchors includes a first side and a second side opposite the first side, the second side including a plurality of linear cuts configured to engage with the actuation screw.

US Pat. No. 10,137,003

LOW PROFILE INTERVERTEBRAL IMPLANT

DePuy Synthes Products, I...

1. A low profile intervertebral implant sized and configured to be implanted between adjacent upper and lower vertebral bodies, the implant comprising:a spacer having a first insertion end, a second end opposite the first insertion end, an upper surface configured to contact the upper vertebral body when the implant is implanted, and a lower surface configured to contact the lower vertebral body when the implant is implanted;
a plate including a first surface and a second surface opposite the first surface, the second surface spaced from the first surface in a first direction, the plate configured to be coupled to the spacer such that the second surface of the plate faces the second end of the spacer, the plate including an upper plate surface configured to face the upper vertebral body when the implant is implanted, the plate including a lower plate surface configured to face the lower vertebral body when the implant is implanted, the plate defining a first through hole configured to receive a first bone screw, the plate further including a first arm that extends from the second surface in the first direction, the first arm including a first inner spacer contacting surface, the plate further including a second arm that extends from the second surface in the first direction, the second arm including a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a second direction that is perpendicular to the first direction; and
a bone fixation element that extends away from the upper plate surface at a location spaced from the first surface in the first direction, the location spaced from the second surface in a direction opposite the first direction;
wherein the second surface, the first inner spacer contacting surface, and the second inner spacer contacting surface combine to define a void that is configured to receive a portion of the spacer, the void defining a first width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a first position, the void defining a second width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a second position, the first width is greater than the second width, and the second width is spaced from the first width in the first direction.

US Pat. No. 10,137,002

STANDALONE INTERBODY IMPLANTS

Globus Medical, Inc., Au...

1. An intervertebral implant for implantation in an intervertebral space between adjacent vertebrae, the implant comprising:a spacer having a superior surface, an inferior surface, a proximal end, and a distal end, wherein the superior surface and the inferior surface each have a contact area configured to engage adjacent vertebrae, the spacer defining an opening extending from the superior surface to the inferior surface of the spacer, and the spacer defining a cutout extending from the proximal end to the opening;
a plurality of inserts, each insert at least partially defining a fastener aperture sized and dimensioned for receiving a fastener; and
a plurality of fasteners, each fastener received in the fastener aperture of each insert for engaging one of the adjacent vertebrae,
wherein each insert is coupled to the spacer such that at least a portion of the insert is received in the cutout in the spacer wherein the superior surface and the inferior surface are configured with a roughened or porous surface, and
wherein the plurality of inserts are spaced from each other,
wherein each of the fastener apertures is positioned in an oblique angle so that the plurality of fasteners extend at an angle from a longitudinal axis of the spacer and configured to engage with one of the adjacent vertebrae,
wherein the spacer includes torsional stabilizers on the superior and inferior surfaces opposite the plurality of inserts.

US Pat. No. 10,137,000

METHOD AND APPARATUS FOR PLACEMENT INTO IATROGENICALLY CREATED SKELETAL VOIDS

1. A method of placing an implant into an iatrogenically created skeletal void within an individual vertebral body, the method comprising:creating a void by removing at least a portion of the individual vertebral body while leaving superior and inferior endplates functionally intact, the void extending through the individual vertebral body from an anterior wall through a posterior wall; and
placing the implant within the void between the superior endplate and the inferior endplate of the individual vertebra such that the implant does not engage with adjacent vertebra thereby permitting the endplates to perform their function.

US Pat. No. 10,136,998

REVISION TOTAL ANKLE IMPLANTS

Wright Medical Technology...

1. A revision implant, comprising:a body extending between a first planar surface and a second planar surface;
a head extending from the first planar surface of the body and configured to couple the revision implant to an additional component of a multi-component prosthesis;
at least one coupling mechanism configured to couple the body to a first bone, wherein the at least one coupling mechanism comprises one or more protrusions extending from the second planar surface of the body; and
a dome-shaped projection extending from the second planar surface and defining a first fastener hole configured to receive a fastener coupling an augment to the body, where the augment is configured to fill a void of the first bone;
wherein the head defines a second fastener hole configured to receive the fastener.

US Pat. No. 10,136,996

IMPLANTABLE PROSTHESIS FOR REPLACING THE HUMAN KNEE JOINT

1. An implantable prosthesis for replacing a human knee joint, comprising:a femoral prosthetic element and a tibial prosthetic element which are articulated with one another by means of a joint device for the purpose of executing a knee bend, the tibial prosthetic element having a through-opening for the passage of a tool, a rod-like tibial shaft anchoring part or an intramedullary lengthening nail,
wherein the joint device is designed to form a guide channel for the passage of the tool, the rod-like tibial shaft anchoring part or the intramedullary lengthening nail from outside, which guide channel is in alignment with the through-opening and is in connection therewith when the tibial prosthetic element and the femoral prosthetic element are arranged at a predetermined angle relative to one another in a functional position corresponding to a knee bend, and
wherein the joint device comprises a joint head which is connected to the femoral prosthetic element and has an interior space in which a joint element connected to the tibial prosthetic element is rotatably guided for guiding the knee bend, a passage opening into the interior space being formed in the joint head and a through-bore being formed in the joint element, the passage and the through-bore being in alignment with one another in the functional position to form the guide channel.

US Pat. No. 10,136,994

COMPOSITE INTERBODY DEVICE AND ASSOCIATED MANUFACTURING METHOD

SB Technologies, LLC, Pa...

1. A composite interbody device, comprising:a plastic core having a superior surface and an inferior surface;
a superior endplate and an inferior endplate, each of the superior and inferior endplates including:
(a) a bone interface side for interfacing with bone and having a plurality of pores permitting bone growth therein, and
(b) a core interface side, opposite the bone interface side, having a plurality of voids that accommodate material of the plastic core to couple the endplate to a respective one of the superior and inferior surfaces, the voids being non-porously isolated from the pores to prevent the material of the plastic core from entering the pores.

US Pat. No. 10,136,993

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair system for repairing a native valve of a patient during a non-open heart procedure, the valve repair system comprising:a delivery device having at least one lumen;
a valve repair device configured to be delivered through the lumen of the delivery device, and configured to attach to a native valve of a patient, the valve repair device comprising:
a pair of paddles that are movable between an open position and a closed position;
wherein each paddle includes a main portion and first and second side portions that are integrally formed with the main portion and extend from the main portion and are configured to contour to the shape of the native valve;
wherein the pair of paddles are configured such that the first and second side portions flex away from the main portion upon being attached to the native valve of the patient; and
a pair of gripping members that are configured to attach to the native valve of the patient.

US Pat. No. 10,136,991

REPLACEMENT HEART VALVE IMPLANT

Boston Scientific Scimed ...

1. A replacement heart valve implant, comprising:a braided anchor member configured to actuate between an elongated delivery configuration and an expanded deployed configuration, the braided anchor member formed from a plurality of filaments;
a circumferential seal member disposed about a distal portion of the braided anchor member, the circumferential seal member including a reinforcing band disposed at a distal end thereof; and
a plurality of valve leaflets connected to the braided anchor member;
wherein the reinforcing band is secured to the braided anchor member adjacent a distal end of the braided anchor member by a plurality of lashings, wherein each lashing is attached to two individual filaments of the plurality of filaments.

US Pat. No. 10,136,990

PIGGYBACK INTRAOCULAR LENS THAT IMPROVES OVERALL VISION WHERE THERE IS A LOCAL LOSS OF RETINAL FUNCTION

AMO Groningen B.V., Gron...

1. An ophthalmic lens configured to improve vision for a patient's eye, the lens comprising:an optic with a first surface and a second surface opposite the first surface, the optic having an optical axis that intersects the first and the second surface, wherein the optic when disposed in an eye of a patient is configured to reduce optical errors together with a cornea and an existing lens in the eye of the patient due to at least one of astigmatism or coma for light incident at an oblique angle with respect to an optical axis of the eye of the patient and focused at a peripheral retinal location disposed at a distance from the fovea and at an eccentricity of about 1 degree to about 25 degrees with respect to the fovea in a horizontal or a vertical plane,
wherein the first surface or the second surface of the optic is configured as a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface described by at least one of (i) aspheric coefficients having an order greater than or equal to 8, or (ii) at least six Zernike coefficients,
wherein a thickness of the optic along the optical axis of the optic is less than 1.0 mm,
wherein a refractive power provided by the optic is between ?5.0 Diopter and +5.0 Diopter, and
wherein an astigmatic power provided by the optic is between 0.5 Diopter and 6.0 Diopter.

US Pat. No. 10,136,987

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

LimFlow GmbH, Dresden (D...

1. A device comprising:a longitudinal axis;
a first end portion having a terminal first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being self-expanding;
a second end portion having a second end diameter smaller than the terminal first end diameter, the second end portion being substantially cylindrical, the second end portion having a second length along the longitudinal axis, the second end portion being self-expanding;
an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end portion and the second end portion, the intermediate portion having a third length along the longitudinal axis, the first end portion being frustoconical, the first end portion tapering between the terminal first end diameter and the intermediate portion; and
a graft material coupled to at least the intermediate portion, the device configured to provide fluid flow between a first passage in which the first end portion is anchored and a second passage in which the second end portion is anchored.

US Pat. No. 10,136,984

SYSTEMS AND METHODS FOR MESH AUGMENTATION AND PREVENTION OF INCISIONAL HERNIA

THE TRUSTEES OF THE UNIVE...

1. A method for affixing mesh to a fascial incision to reinforce and augment hernia fascia closures, comprising:aligning a mesh strip over the fascial incision using an applicator, the mesh strip being integrated with one or more uni-directional fasteners, each fastener including at least one anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface, the applicator comprising a first tension arm and a second tension arm adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the first and second tension arms adapted to spread the first and second tension arms;
controlling a first horizontal tension of the mesh strip when the mesh strip is placed on the fascial incision by using the handle to spread the first tension arm a first distance from the second tension arm, the first distance corresponding to the first horizontal tension of the mesh strip, wherein the first horizontal tension corresponds to a predetermined amount of horizontal tension applied to the mesh strip by the applicator without application of external force;
affixing the mesh strip under the vertical tension and the first horizontal tension to the anterior abdominal wall fascia by applying a force to the fasteners to thereby achieve tissue penetration of the at least one anchoring mechanism of the one or more fasteners; and incrementally tensioning the mesh strip placed on the fascial incision to reinforce the fascial incision by using the handle to spread the first tension arm from the second tension arm by a second distance that is greater than the first distance, wherein an incremental horizontal tension corresponds to the second distance, the incremental horizontal tension being greater than the first horizontal tension.

US Pat. No. 10,136,982

POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS

Tepha, Inc., Lexington, ...

1. A knitted mesh, woven mesh, nonwoven mesh or braid comprising a poly-hydroxybutyrate homopolymer multifilament yarn, wherein the multifilament yarn has a tenacity of greater than 0.5 g/denier and is produced by a method comprising melt extrusion, allowing the extrudate dwell time to crystallize and drawing the resulting fiber.

US Pat. No. 10,136,981

TISSUE ANCHOR SYSTEM INCLUDING A SUTURE SECURING AN ANCHOR TO A SUPPORT

1. A tissue anchor system comprising:a support having a base and arms extending from the base, where the arms include a first arm separated from a second arm by a central portion of the support, where the support is a knitted mesh having open pores;
a suture inserted through the support, with a first trailing end portion and a second trailing end portion of the suture maintained inside of a conduit;
an anchor comprising a body, a fin extending from the body in a first direction with an eyelet formed in the fin, a pair of radial barrels extending from opposite sides of the body in a radial direction perpendicular to the first direction, with the suture engaged with the eyelet of the fin, and a gripping tab removably attached to the fin, where the gripping tab is adapted to be removed from the fin prior to insertion of the anchor into tissue; and
an introducer having a cannula defining a bore sized to receive the body of the anchor and a slot formed in a wall of the cannula, with the slot sized to receive the fin of the anchor.

US Pat. No. 10,136,980

IMPLANTS AND PROCEDURES FOR SUPPORTING ANATOMICAL STRUCTURES FOR TREATING CONDITIONS SUCH AS PELVIC ORGAN PROLAPSE

Caldera Medical, Inc., A...

1. A method for supporting an anatomical structure comprising:(a) making an entry point in a body of a patient;
(b) engaging a first anchor with a delivery system and inserting the first anchor through the entry point and into a target tissue of the body;
(c) retracting the delivery system from the first anchor and out from the entry point;
(d) reengaging the delivery system with the first anchor by passing a suture extending from the first anchor and out the entry point through a slot in the delivery system and advancing the delivery system towards the first anchor until the first anchor is received by the delivery system;
(e) adjusting a position of the first anchor in the target tissue with the delivery system and retracting the delivery system from the first anchor and out from the entry point after said adjusting;
(f) positioning a support member between the first anchor and a second anchor secured within said body;
(g) locking said support member in position relative to the first and second anchors by passing a mesh portion of the support member through an aperture of one of the first and second anchors and engaging said mesh portion of said support member with projections extending from an interior of the aperture by releasing a tension of a suture loop that passes through said aperture; and
(h) closing said entry point.

US Pat. No. 10,136,979

METHOD FOR CONTROLLING FLOW OF INTESTINAL CONTENTS IN A PATIENT'S INTESTINES

1. An intestinal dysfunction treatment apparatus comprising:an implantable constriction device configured to gently constrict at least one wall portion of a tissue wall of a patient's intestines to restrict a flow of intestinal contents in an intestinal passageway of the intestine's,
a stimulation device configured to stimulate the at least one wall portion of the tissue wall, and
a control device configured to be operable to control the stimulation device to stimulate the at least one wall portion, as the constriction device constricts the at least one wall portion, to cause contraction of the at least one wall portion to further restrict the flow of intestinal contents, wherein the control device is configured to control the constriction device to adjust the constriction of the at least one wall portion, and the control device is configured to control the constriction and stimulation devices independently of each other,
wherein the control device is configured to calibrate the constriction of the at least one wall portion by stimulating the at least one wall portion while adjusting, the constriction of the at least one wall portion until a desired restriction of the flow of intestinal contents in the intestinal passageway is obtained.

US Pat. No. 10,136,978

DOSING APPARATUS

Imaginus Limited, (NZ)

1. A dosing apparatus for dispensing therapeutic and/or preventative product into an orifice of an animal, comprising:a plurality of interlocking cartridges arranged in a stack, each cartridge containing at least one product, and each cartridge including:
a body with a cavity holding at least one product to be dosed,
a nozzle which is in communication with the cavity and which is configured for channelling the product to an orifice of an animal, the nozzle being disposed on the top of the body whereby product is dispensed upwardly from the dosing apparatus to the orifice of the animal,
at least one piston configured to push product from the cavity, and
a recess which is adapted to receive and provide a cover for the nozzle of an identical or similar cartridge; and
a dispenser for holding the cartridges and for dispensing product from each cartridge, one after the other, the dispenser including:
a magazine adapted to receive the stack of cartridges, and
a plunger arranged to drive the piston (s) of one of the cartridges;
wherein the nozzle comprises a cannula without a needle;
wherein the nozzle comprises a tubular section sized to fit within the teat orifice of a dairy cow for mastitis prevention and treatment; and
wherein the nozzle is disposed at an angle relative to the body of 70°-90°.

US Pat. No. 10,136,977

DENTAL TESTING DEVICE FOR HEAT SENSITIVITY

1. A device for testing a heat sensitivity in teeth comprising:a base; and
a testing tip having a cushion,
wherein the cushion comprises a heating element, wherein said heating element is embedded in said cushion; and
wherein the cushion is conformable to a contour of a tooth to be tested for a heat sensitivity and is conformable to contours of different types of teeth and wherein the cushion has a left side and a right side that are mirror images of each other that allows testing of all upper and lower teeth individually; and
being capable of transferring heat energy from the cushion to the top surface and at least one side surface of a tooth tested for heat sensitivity, wherein the surface of the cushion is adaptable to the surface of the tooth for greater surface area contact between the cushion and the tooth enamel allowing for heat energy transfer to the tooth over a larger area and at a level to prevent damage to the enamel layer, the dentine layer, or pulp tissue in the tooth being tested.

US Pat. No. 10,136,976

TOOTHBRUSH VIBRATOR

M-SYSTEM CO., LTD., Osak...

1. A toothbrush vibrator comprising:a vibration applicator having a case that allows a toothbrush to pass therethrough and holds the toothbrush and applying vibration to the toothbrush, the case being hollow pillar-shaped body; and
a grip detachably connected to the vibration applicator and gripped by a user,
wherein the grip has a case that is a hollow pillar-shaped body and is capable of housing a portion of a handle of the toothbrush that protrudes from the vibration applicator toward the grip,
the vibration applicator includes a first magnet provided at a grip-side end portion of the vibration applicator,
the grip includes a second magnet provided at a vibration applicator-side end portion of the grip, and
the vibration applicator and the grip are detachably connected by force of the first magnet and the second magnet attracting each other.

US Pat. No. 10,136,971

POSITIONING JIG AND IMPROVED METHODS TO DESIGN AND MANUFACTURE DENTAL IMPLANTS

1. A method of preparing an artificial prosthesis having two or more adjacent teeth which comprises:(a) preparing an artificial tooth arrangement (ATA) with two or more adjacent teeth in a mold on a positioning jig comprising a member with (i) three or more parallel bores in the member and (ii) one or more means for attaching the member to a dental articulator;
(b) placing at least three rigid struts in the parallel bores of the positioning jig;
(c) using at least one of the rigid struts to align a drill;
(d) drilling an aligned hole into each of the teeth in the mold;
(e) placing a rod in each of the aligned holes of the teeth to form a series of aligned rods;
(f) using the teeth and the aligned rods to prepare a dental mockup;
(g) copying the dental mockup to prepare a dental bridge; and
(h) affixing the teeth using the aligned holes to the dental bridge so as to prepare the artificial prosthesis.

US Pat. No. 10,136,968

DISPOSABLE SURGICAL INTERVENTION GUIDES, METHODS, AND KITS

ISETHCO LLC, San Diego, ...

1. A removable modular surgical guide assembly, comprising:a deformable casting medium, wherein the deformable casting medium defines an open treatment area when positioned on a dentiture of a subject;
a foundation plate circumscribing the open treatment area; and
a sensor array affixed to the foundation plate, the sensor array comprising a flexible circuit having at least two electromagnetic sensors, wherein the at least two sensors are positionable around the open treatment area at, or about at, a gumline of the dentiture of the subject,
wherein the foundation plate and the deformable casting medium are comprised of different materials, and the foundation plate is positioned in contact with the deformable casting medium.

US Pat. No. 10,136,966

ORTHODONTIC APPLIANCE

Dentbend BVBA, Liederker...

1. An orthodontic appliance comprising:a plurality of brackets, each bracket having a base for connection to a surface of a tooth within a row of teeth; and
a body configured to be coupled to each of said brackets, the body being provided with a plurality of connection elements arranged on the body, each connection element being configured to cooperate with a respective one of the plurality of brackets to form a connection between the body and the respective bracket,
wherein each connection element comprises a slot,
wherein each bracket comprises a locking element and a stem protruding from the base to connect the locking element to the base, the locking element being configured to be inserted into the slot of a respective connection element, the locking element being substantially disc-shaped and elongated in a primary axis of the respective tooth and having a larger diameter than the stem,
wherein the locking elements of the plurality of brackets and the slots of the plurality of connection elements define locking means for removably connecting the body to the plurality of brackets via the plurality of connection elements,
wherein the slot of each connection element is configured to fit around the locking element of the respective bracket, the slot comprising mating surfaces configured to form a mating engagement with the locking element of the respective bracket and at least one guiding surface configured to guide a top surface of the locking element into the slot, said at least one guiding surface running inward starting at a lower edge of the slot, the slot being a latching slot comprising a tip or protruding section at an interface between said at least one guiding surface and said mating surfaces,
wherein each connection element further comprises a first aperture through which the locking element of the respective bracket can be inserted into the slot and a second aperture configured to slide over the stem of the respective bracket,
wherein the stems of the plurality of brackets are configured so that a distance between the body and the row of teeth is sufficient for insertion and removal of the body and for cleaning of the brackets,
wherein the stem of each of the plurality of brackets is arranged on the base outside of a center of the base and a central axis of the stem is shifted with respect to a central axis of the base such that the stem is configured to define a position of the body that is shifted along the primary axis of the respective tooth with respect to a plane extending perpendicular to the primary axis of the respective tooth and through a center of the row of teeth.

US Pat. No. 10,136,963

SYSTEM AND METHOD FOR INTRODUCING PHOTOSENSITIVE DYES VIA AN INSERT INTO A ROOT CANAL IN A TOOTH, METHOD FOR PRODUCING SAID DYE IMPREGNATED INSERT AND METHOD OF USING SAID DYE-IMPREGNATED INSERT

1. A bactericidal insert for introduction into a canal in a tooth during a root canal procedure, said insert comprising a carrier having a plurality of pores or interstices having been impregnated with a liquid photosensitive dye so that said dye enters said pores or interstices and then said carrier with said liquid photosensitive dye forms a dye-impregnated carrier, said dye-impregnated carrier being configured for insertion within the canal of the tooth and also, the dye can be wet or dried and, if dried, configured to be wetted to dissolve said dye to produce a liquefied dye, said liquefied dye being activatable to produce singlet oxygen or free radicals within said canal when irradiated by light from outside of the tooth;wherein said insert is configured so that a wetting agent can be added thereto to wet said dry dye-impregnated carrier and wherein said insert is packaged in a package with said wetting agent.

US Pat. No. 10,136,962

MULTI-PLANAR PRE-CURVED ROTARY ENDODONTIC FILE

Dentsply Sirona, Inc., Y...

1. An improvement endodontic instrument configured for use in a rotary hand piece and having a working length made of a shape memory material and including a plurality of flutes forming a cutting edge, the improvement comprising:the working length including
a straight non-apical portion whose central longitudinal axis is a central rotational axis of the endodontic instrument and
a pre-curved apical portion whose central longitudinal axis does not lie along the central rotational axis of the endodontic instrument,the pre-curved apical portion beginning at about one-third to one-quarter of the working length as measured from a tip end of the endodontic instrument and ending at the tip end, the pre-curved apical portion having at least three curvatures including at least one curvature that spirals about the central rotational axis of the endodontic instrument, the at least one curvature having a radius of curvature “R” which places the tip end at an angle in a range of about 300 to 750 relative to the central rotational axis.

US Pat. No. 10,136,961

DENTIST TOOL

Viax Dental Technologies,...

1. An overlay for guiding a dental cutting tool defining a longitudinal axis in the removal of predetermined tooth structure from a tooth to be treated, the overlay comprising:an inner surface having a shape and dimensions corresponding to and configured for contacting a contact region on and extending at least partially around either of or both an outer surface of the tooth to be treated and an outer surface of a neighboring tooth of the tooth to be treated such that the inner surface remains releasably fixed to the contact region and in the same position relative to the tooth to be treated upon application of pressure to the overlay during guiding of the dental cutting tool in normal use of the overlay;
a first guiding edge extending through a thickness of the overlay including through the inner surface, the first guiding edge having a contour corresponding to any one or any combination of horizontal, vertical, and tilt movements to be followed by the dental cutting tool in a direction transverse to the longitudinal axis of the dental cutting tool; and
a second guiding edge extending through the thickness of the overlay including through the inner surface, the second guiding edge being spaced apart from the first guiding edge and having a contour corresponding to any one or any combination of the horizontal, vertical, and tilt movements to be followed by the dental cutting tool,
wherein the inner surface of the overlay is configured for extending between top and bottom portions of the respective one or both of the outer surface of the tooth to be treated and the outer surface of the neighboring tooth of the tooth to be treated to which the inner surface corresponds and on which the inner surface is configured for contacting a contact region, the inner surface of the overlay being configured for contacting the respective bottom portion or portions at a respective location or respective locations adjacent to a gingiva of the patient.

US Pat. No. 10,136,960

HAND-HELD ELECTROSURGICAL INSTRUMENT

1. A hand-held instrument, comprising:a handle portion;
an electrosurgical electrode supportably interconnected to and extending distally away from a first end of said handle portion in a first direction;
a signal cable, extending proximally from a proximal end of the handle portion to an interconnected coupler end that is provided to interface with an electrosurgical generator, for transmission of electrosurgical signals to the electrosurgical electrode via the signal cable;
at least one electrically-powered light source, interconnected to said handle portion, for emitting light in said first direction to illuminate a volume extending along the electrosurgical electrode from said first end of the handle portion to a distal end of the electrosurgical electrode;
at least one battery, disposed remotely from said handle portion, to provide electrical power to said at least one light source as a DC signal;
an electrical cable, extending proximally from the proximal end of the handle portion to an interconnected battery module for supporting said at least one battery, to provide said electrical power from said at least one battery to said at least one light source via the electrical cable; and
a switch, interconnected to said handle portion and in electrical communication with said at least one battery by said electrical cable, for selective activation of said at least one light source by said electrical power form said at least, one battery.

US Pat. No. 10,136,953

COMPUTER ASSISTED SURGERY APPARATUS AND METHOD OF CUTTING TISSUE

1. A computer assisted surgery apparatus, the apparatus comprising:a surgical instrument having an intervention member to cut tissue of a body part of a patient;
a control unit arranged to automatically control position and orientation of the intervention member of the surgical instrument in relation to the body part of the patient with regard to a predefined osteotomic line on the body part of the patient; and
a tracking device arranged to track a position and orientation of the body part of the patient,
wherein the surgical instrument comprises an optical monitoring system being fixedly mounted in relation to the intervention member of the surgical instrument, the optical monitoring system being arranged to continuously detect positions of marks applied to the body part of the patient, and
wherein the control unit is arranged to adjust position or orientation, or position and orientation of the intervention member of the surgical instrument when a predefined deviation of the positions of the marks is detected.

US Pat. No. 10,136,950

PATIENT-MATCHED SURGICAL COMPONENT AND METHODS OF USE

Biomet Manufacturing, LLC...

1. A method of performing a surgical procedure aided by a surgical navigation system, comprising:generating a representative model of an anatomical feature from an image of a patient's anatomy;
using the model to make a virtual surgical component;
installing the virtual surgical component on the representative model of the anatomical feature by mating the surface of the component with the anatomical feature in the predefined spatial relationship;
tracking movement of the anatomical feature with a tracking system when a physical surgical component corresponding to the virtual surgical component is moved within a measurement field of the tracking system;
tracking movement of a surgical cutting instrument with the tracking system;
displaying the representative model and the surgical cutting instrument on a display of the surgical navigation system; and
guiding the surgical cutting instrument on the display to verify a cutting plane of the surgical cutting instrument relative to the anatomical feature.

US Pat. No. 10,136,942

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,941

SURGICAL INSTRUMENT AND METHOD OF CREATING THE SAME

JSTONE INC., Mundelien, ...

1. A surgical instrument comprising:a handle portion;
a cylindrical hollow tube secured to the handle portion the cylindrical hollow tube having a first end and a second end wherein the second end of the cylindrical hollow tube is secured to the handle portion;
a clevis unit secured within a cylindrical covering wherein the cylindrical covering has a first end and a second end and wherein second end of the cylindrical covering is located adjacent to the first end of the cylindrical hollow tube;
a first blade and a second blade wherein a portion of the first blade and a portion of the second blade are secured within the clevis unit;
a rubber seal partially covered by the first end of the cylindrical hollow tube and partially covered by the second end of the cylindrical covering;
a first end of the first blade and a second end of the first blade;
a first end of the second blade and a second end of the second blade; and
wherein the second end of the first blade and the second end of the second blade do not extend outside of a circumference of the clevis unit at any time, while the first end of the first blade and the first end of the second blade extend outside of the circumference of the clevis unit.

US Pat. No. 10,136,940

APPARATUS FOR PERFORMING AN ELECTROSURGICAL PROCEDURE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a housing;
at least one shaft extending from the housing, the at least one shaft defining a longitudinalaxis;an end effector assembly operatively connected to a distal end of the at least one shaft having first and second jaw members, at least one of the first and second jaw members pivotable relative to the other from an open position wherein the first and second jaw members are disposed in spaced relation relative to one another, to a clamping position wherein the first and second jaw members cooperate to grasp tissue therebetween under a sealing pressure;
a pivot pin providing an axis of pivot for the pivotable jaw member; and
a monolithic jaw insert operably disposed within at least one of the first and second jaw members, the jaw insert defining an opening configured to securely house the pivot pin, the jaw insert including a moveable member configured to engage a cam pin and configured to provide a camming force to the cam pin and a portion of the sealing pressure to the jaw members when the first and second jaw members are in the clamping position.

US Pat. No. 10,136,938

ELECTROSURGICAL INSTRUMENT WITH SENSOR

Ethicon LLC, Guaynabo, P...

1. An apparatus for operating on tissue, the apparatus comprising:(a) a body;
(b) a shaft extending distally from the body;
(c) an end effector configured to receive energy from an energy source, wherein the end effector comprises:
(i) a first jaw, and
(ii) a second jaw, wherein the second jaw is pivotable relative to the first jaw to transition the end effector from an open configuration to a closed configuration, wherein the first jaw and second jaw define a closure gap between each other when the end effector is in the closed configuration;
(d) a first movable member operatively coupled with the second jaw, wherein the first movable member is configured to move in response to pivoting of the second jaw relative to the first jaw; and
(e) a sensor, wherein the sensor includes a second movable member configured to be engaged by the first movable member, wherein the second movable member is moveable from a first position to a second position in response to movement of the first moveable member when the end effector transitions from the open configuration to the closed configuration,
wherein the sensor is operable to detect that the end effector is in the closed configuration when the second movable member moves to the second position, wherein the sensor is in communication with the energy source, wherein the sensor is operable to communicate a signal to the energy source when the sensor detects the end effector in the closed configuration.

US Pat. No. 10,136,935

DEVICE FOR THE CONTROLLED REMOVAL OF OSSEOINTEGRATED IMPLANTS AND IMPROVED OSSEODISINTEGRATABLE IMPLANTS

1. A medical device for releasing an implant from a bone of a patient to which the implant adheres to, the medical device comprising:a heating/cooling device configured to produce or release heating energy and/or a cooling agent to heat and/or cool the implant;
a controlling device configured to control the heating/cooling device, wherein the controlling device comprises a database storing information and controls the heating/cooling device based on the information stored in the database;
wherein the database comprises:
implant information; and
information defining a temperature, a temperature curve, a heating time, a cooling time, and a frequency of heating and/or cooling suitable to effect osseodisintegration of the implant based on the implant information;
a coupling device configured to releasably connect to the implant while the implant adheres to the bone of the patient, wherein the coupling device is configured to transfer the heating energy and/or the cooling agent produced or released by the heating/cooling device to the implant; and
an input device operably linked with the controlling device, wherein the input device is configured to receive a parameter from an operator operating the medical device, wherein the parameter:
(i) defines a type, dimension, mass, surface structure and/or material of said implant; and/or
(ii) defines an expected amount of osseointegrated surface on the implant; and/or
(iii) defines an amount and/or duration of the heating and/or cooling; and/or
(iv) defines an expected position or region of the osseointegrated surface on the implant; and/or
(v) is selected from the group consisting of
(a) information defining a type, dimensions, mass, surface structure and/or material of the implant or a cavity geometry within the implant;
(b) information defining a form of the coupling device or information defining a thermal conductivity of the coupling device;
(c) information defining a surface of the implant which is osseointegrated;
(d) information defining a type of heating energy and/or cooling agent to be used or information defining an amount of heating energy and/or cooling agent necessary to reach osseodisintegration of an implant as defined in (a); and
(e) information for controlling the heating/cooling device to heat or cool the implant to achieve osseodisintegration of bone material contacting the implant or located within a distance of less than a predefined distance from the surface of said implant;
and/or
(vi) defines bone density of the bone contacting or surrounding the implant; and/or
(vii) defines a date on which the implant was implanted into the patient; and/or
(viii) defines an age of the patient.

US Pat. No. 10,136,932

SPINAL PLATE AND DISTRACTION/COMPRESSION PIN SYSTEM

Camber Spine Technologies...

1. A cervical fixation plate and distraction pin system comprisingtwo or more distraction pins, and
a cervical fixation plate comprising
two or more boreholes for insertion of screws to position and secure the plate on the vertebral surfaces, and
two or more slots for placement of the two or more distraction pins,
wherein one of the slots is located at the inferior end of the plate and another of the slots is located at the superior end of the plate,
wherein each of the slots comprises two parallel straight side walls, and each of the slots is elongated along a longitudinal axis extending along a centerline of the plate, and wherein at least a portion of each of the side walls is ridged and contains a plurality of teeth, wherein the teeth are configured to mate with and secure the plate to a respective one of the pins and are configured to create and maintain compression across a disc space prior to and during securing of the plate on the vertebral surfaces,
wherein two of the boreholes are aligned along an axis substantially parallel to the longitudinal axis, the two boreholes disposed laterally with respect to each of the slots, and
wherein each pin comprises a threaded bone entry end and a ridged portion configured to retain the pin in the respective one of the two or more slots to secure the plate to the vertebral surfaces before attaching the screws, and wherein each pin is configured for removal from the respective one of the two or more slots.

US Pat. No. 10,136,931

BONE FIXATION DEVICE AND METHOD

1. An apparatus for fixation of a fractured bone, comprising:an elongated fixation plate having a longitudinal axis adapted to extend along a long axis of the fractured bone and including a first portion extending along the longitudinal axis of the fixation plate adapted for attachment to a first fragment of the fractured bone and a second portion extending in an opposite direction from the first portion along the longitudinal axis of the plate adapted for attachment to a second fragment of the fractured bone such that the fixation plate is adapted to extend across a fracture between the first fragment and the second fragment of the fractured bone;
a rotational member having a body and a first tab and a second tab extending outwardly and bending in a direction away from a plane of the body; and
a fastener for attaching the body of the rotation member to the elongated fixation plate;
wherein the tabs extending outwardly from the body are adapted for engaging the fractured bone to apply force to the first and second fragments transversely across opposite sides of the fractured bone to produce a torque across the fracture.

US Pat. No. 10,136,930

FLEXIBLE FASTENING DEVICE FOR INDUSTRIAL USE

1. A flexible fastening device to secure two components having curved or misaligned entry paths adjacent one another, said flexible fastening device being a rigid material and having:a body, said body having a length and a diameter, said length to diameter aspect ratio being at least 2, and multiple segments,
one of said multiple segments being a leading segment,
at least one of said multiple segments being a hollow segment;
at least two sinuous slots along at least a portion of said hollow segment to form at least one flexible segment, a first of said at least two sinuous slots extending along a first portion of said hollow segment and a second of said at least two sinuous slots extending along a second portion of said hollow segment,
one of said multiple segments being a trailing segment having a receiving area to receive a rotational force device.

US Pat. No. 10,136,929

FLEXIBLE BONE IMPLANT

IntraFuse, LLC, Logan, U...

1. A bone implant comprising an elongate body having a distal portion and a proximal portion spaced longitudinally relative to a longitudinal axis, wherein:the proximal portion comprises:
a non-threaded outer surface; and
a fully-bounded transverse bore passing through the proximal portion from a first fully-bounded opening in the non-threaded outer surface to a second fully-bounded opening in the non-threaded outer surface; and
the distal portion comprises a helical distal thread formed thereon, the helical distal thread having a major diameter, a minor diameter, and a pitch, the helical distal thread being operable to bend as it is threaded into a bone to follow a curved path, the helical distal thread having a bending stiffness lesser than a bending stiffness of the proximal portion,
wherein a ratio of a bending stiffness of the proximal portion to the bending stiffness of the distal portion is in the range of 2:1 to 20:1.

US Pat. No. 10,136,928

ROD LINK REDUCER

Globus Medical, Inc., Au...

1. A rod link reducer assembly comprising:a manipulator rod having a first end, a second end, and an elongate body extending along a body axis between the first end and the second end;
a post extending outwardly from the rod; and
a rod manipulating joint comprising:
an elongate joint rod extending along a joint rod axis;
a first coupling clamp disposed along the joint rod, the first coupling clamp releasably connectable to the post;
a second coupling clamp disposed along the joint rod adjacent to and rotatable about the joint rod relative to the first coupling clamp, the second coupling clamp releasably connectable to a second post; and
a first biasing member adapted to bias the second clamp against the first clamp,
at least two screw assemblies, a construct adapted to extend between the at least two screw assemblies,
wherein the second end of the manipulator rod comprises a tip, the tip comprising a receiver adapted to releasably secure the construct therein and a receiver axis extending orthogonally to the body axis,
wherein the receiver further comprises a securing member to releasably secure the construct to the receiver, the securing member extending at an angle oblique to the receiver axis, and
wherein the securing member comprises a set screw engaged with a threaded passage and a retainer pin located in the passage to prevent removal of the set screw from the passage.

US Pat. No. 10,136,926

EXPANDABLE SPINAL FIXATION SYSTEM

Globus Medical, Inc., Au...

1. An expandable spinal fixation system comprising:an expandable barrel assembly having:
an upper barrel half having a distal end and a proximal end, wherein the proximal end of the upper barrel comprises a slot formed therein;
a lower barrel half having a distal end and a proximal end, wherein the proximal end of the lower barrel comprises a projection portion configured to be received in the slot; and
a securing assembly having a plate adapted to bias the projection against the upper barrel proximal end and a securing member adapted to releasably bias the plate against the projection, and wherein, when the securing member biases the plate against the projection, the lower barrel half is fixed relative to the upper barrel half; and
a fixed barrel assembly having a body sized to fit between the upper barrel half and the lower barrel half, wherein the body extends along a longitudinal axis,
wherein the upper barrel half is capable of moving with respect to the lower barrel half.

US Pat. No. 10,136,924

POLYAXIAL BONE SCREW

DePuy Synthes Products, I...

1. A polyaxial bone anchor assembly, comprising:a shank having a spherical head formed on a proximal end thereof;
a receiver member adapted to receive a spinal rod and having a distal opening though which the shank extends and a distal seat in which the head of the shank is polyaxially seated; and
a compression cap that is spring biased in a distal direction relative to the receiver member such that the compression cap exerts distal pressure on the spherical head of the shank to frictionally engage the spherical head of the shank.

US Pat. No. 10,136,923

POLYAXIAL BONE FIXATION ELEMENT

DePuy Synthes Products, I...

1. An assembly configured to couple a spinal rod to a vertebra, the assembly comprising:a body that is elongate along a first longitudinal axis, the body including an upper end that defines an upper opening, a lower end that defines a lower opening, a bore that extends between the upper opening and the lower opening along the longitudinal axis, the bore defining a rod-receiving channel configured to receive the spinal rod, the rod-receiving channel disposed along a channel axis that is oriented substantially perpendicular to the longitudinal axis, the bore at least partially defined by a first curved surface that forms a first spherical undercut having a first body diameter, and the bore at least partially defined by a second curved surface that forms a second spherical undercut having a second body diameter that is larger than the first body diameter, the first curved surface positioned closer to the lower opening with respect to a direction parallel to the longitudinal axis than the second curved surface is to the lower opening with respect to the direction, the body further including a collet retention feature positioned at a fixed location between the upper opening and the second curved surface such that the collet retention feature is configured to inhibit movement of a collet that is between the collet retention feature and the lower opening from passing through the upper opening, the collet retention feature defining a retention opening having a third body diameter, and the lower opening defining a fourth body diameter; and
a bone anchor that is elongate along a second longitudinal axis, the bone anchor including a head portion, a shaft portion, and a neck portion positioned between the head portion and the shaft portion, the head portion defining a first screw diameter measured perpendicular to the second longitudinal axis, the shaft portion defining a second screw diameter measured perpendicular to the second longitudinal axis, and the neck portion defining a third screw diameter perpendicular to the second longitudinal axis,
wherein the third screw diameter is less than both the first screw diameter and the second screw diameter, the first screw diameter is less than both the first body diameter and the second body diameter, and the third body diameter is greater than the fourth body diameter and less than the second body diameter.

US Pat. No. 10,136,922

BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE

1. A bone anchoring device comprising:a bone anchoring element;
a receiving part for coupling a rod to the bone anchoring element, the receiving part comprising:
a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving the rod, the recess extending from the first end in a direction of the second end and defining two free legs; and
a second portion at the second end of the rod receiving portion that is connectable to the bone anchoring element, wherein when the bone anchoring element is connected to the second portion of the receiving part, the bone anchoring element and the receiving part are pivotable relative to one another; and
a locking ring configured to be arranged around the second portion of the receiving part, the locking ring comprising a first end, a second end, and an outer surface extending between the first and second ends;
wherein when the bone anchoring element is connected to the second portion of the receiving part and the locking ring is around the second portion, the locking ring can assume a locking position where a compressive force is exerted on the bone anchoring element to lock an angular position of the bone anchoring element relative to the receiving part; and
wherein an engagement structure comprising a projection or a groove is provided on the outer surface of the locking ring, and wherein a portion of the engagement structure forms an abutting surface positioned away from end faces at the first and second ends of the locking ring that is configured to be pushed by a tool to move the locking ring away from the first end of the rod receiving portion towards the locking position, the abutting surface having at least a section that extends axially when viewed in a circumferential direction around the locking ring.

US Pat. No. 10,136,920

ADJUSTABLE CALCANEAL RESTRAINT SYSTEM

1. A treatment method for treating injuries to a patient's calcaneus performing a first surgical procedure wherein a calcaneal pin aperture is created laterally through a patient's calcaneus;inserting a calcaneal pin transversely through the patient's calcaneus;
providing an adjustable calcaneal restraint apparatus, the adjustable calcaneal restraint apparatus comprising:
a rigid framework with a first end configured to be affixed to a lower leg of the patient, and a second end configured for support transverse to the patient's heel;
an adjustment member operably connected to a first end and a second end of the calcaneal pin by a cable, the adjustment member being movably mounted to the second end of the rigid framework such that it can be set in transverse positions across the second end of the rigid framework; and
wherein movement of the adjustment member relative to the second end of the rigid framework changes the calcaneus pin angle;
securing the adjustable calcaneal restraint apparatus to the patient;
adjusting the adjustable calcaneal restraint apparatus to manipulate the patient's calcaneus or pieces of the patient's calcaneus;
imparting a biasing force on the cable between the adjustment member and the calcaneal pin;
waiting an amount of time for the patient's calcaneal and surrounding tissue to be in a desirable condition to perform a second surgical procedure; and
performing the second surgical procedure on the patient's calcaneus to fix the calcaneus or pieces of the calcaneus in a desired location while the adjustable calcaneal restraint apparatus is fixed to the patient.

US Pat. No. 10,136,916

ACCESS DEVICE

Access Scientific, LLC, ...

1. An access device for placing a medical article within a body space, comprising:a needle having an elongated needle body with a distal end and a needle hub from which the needle body extends;
a dilator slideably disposed on the needle body and comprising a dilator hub and an elongated dilator shaft that extends from the dilator hub to a distal end, the dilator hub comprising a receiving portion; and
an insert disposed within the dilator hub and supported by the receiving portion, the insert comprising a through-hole configured to receive the needle body therethrough such that the needle body is capable of extending through the insert, at least a portion of the through-hole being sized and shaped relative to the needle body so as to form a space between the insert and the needle body that allows gases to pass through the space and to the atmosphere but hinders the passage of a body fluid through the space.

US Pat. No. 10,136,915

ULTRASOUND NEEDLE GUIDE APPARATUS

LOVING HEART MEDICAL TECH...

1. An ultrasound needle guide apparatus to aid guidance of a puncturing needle to locate blood vessel positions of a living body and perform puncturing operation, comprising:an ultrasound detection device including a probe head which is configured to contact with the living body to detect the blood vessel positions via ultrasonic waves, a grip shell connected to the probe head, a first hinge portion located on the grip shell, and an image process unit located in the grip shell and electrically connected to the probe head;
a display element which is rotatably connected to the grip shell and includes a second hinge portion hinged on the first hinge portion and a display screen electrically connected to the image process unit through the first hinge portion and the second hinge portion to get ultrasonic signals from the probe head and display the blood vessel positions of the living body; and
a needle positioning aid element fastened to the ultrasound detection device and located beside the probe head, including a body fixed on the ultrasound detection device and a positioning aid support portion located at one side of the body remote from the ultrasound detection device to aid positioning of the puncturing needle;
wherein the body includes a curved section and two clamp sections at two ends of the curved section, the two clamp sections is corresponding with the curved section to clamp the grip shell from two sides of the grip shell, the grip shell includes two guide trough respectively corresponding to the two clamp sections that has an axis perpendicular to the probe head.

US Pat. No. 10,136,908

COAXIAL COIL LOCK

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing;
an elongated shaft extending distally from the housing and defining a longitudinal axis, the elongated shaft including a flexible portion configured to movably support an end effector such that, bending of the flexible portion is configured to induce pivotal movement of the end effector with respect to the longitudinal axis; and
a locking mechanism coaxially disposed about the flexible portion and selectively rotatable relative to the flexible portion about the longitudinal axis, wherein upon rotation of the locking mechanism about the longitudinal axis in a first direction, the locking mechanism is configured to laterally engage the flexible portion to impede bending of the flexible portion and pivotal movement of the end effector, and wherein upon rotation of the locking mechanism about the longitudinal axis in a second direction, the locking mechanism is configured to laterally disengage from the flexible portion enabling flexure of the flexible portion and pivotal movement of the end effector.

US Pat. No. 10,136,907

METHODS OF LOCATING AND TREATING TISSUE IN A WALL DEFINING A BODILY PASSAGE

COOK MEDICAL TECHNOLOGIES...

1. A delivery device, comprising:a housing having a housing proximal end, a housing distal end, and a housing body defining a housing lumen;
a cannula having a cannula proximal end, a cannula distal end, and a cannula body defining a cannula lumen, the cannula attached to the housing such that the housing lumen and the cannula lumen are in communication;
a pusher having a pusher proximal end, a pusher distal end slidably disposed within the housing lumen, and a pusher body that defines a pusher lumen, the pusher moveable between a pusher first configuration and a pusher second configuration; and
a catheter attached to the pusher and having at least a portion disposed within the cannula lumen, the catheter comprising an elongate member and a balloon, the elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member body defining an inflation lumen in communication with the pusher lumen and an elongate member curve, the balloon disposed on the elongate member and having a wall defining a balloon chamber in communication with the inflation lumen, the balloon moveable between a first deflated configuration and a second inflated configuration as fluid is moved into and out of the balloon chamber, the elongate member adapted to move between a first substantially straight configuration in which the portion of the elongate member that defines the elongate member curve is substantially straight when disposed within the cannula lumen and a second curved configuration when the portion of the elongate member that defines the elongate member curve is free of the cannula lumen.

US Pat. No. 10,136,905

BALLOON CATHETER

ASAHI INTECC CO., LTD., ...

1. A balloon catheter comprising:a balloon;
an outer shaft;
an inner shaft joined to a distal end of the balloon and comprising a coil body; and
a tip having:
a step portion provided on an inner surface thereof and configured to come in contact with a distal end of the inner shaft; and
a proximal end portion that covers an outer periphery of the distal end of the balloon,
wherein:
the distal end of the balloon is sandwiched between the inner shaft and the proximal end portion of the tip,
an outer periphery of the inner shaft has an uneven surface topography, corresponding to the shape of the coil body, at a joining portion in which the distal end of the balloon, the inner shaft, and the tip are joined, and
an inner periphery of the distal end of the balloon at the joining portion has an uneven surface topography corresponding to the uneven surface topography of the outer periphery of the inner shaft.

US Pat. No. 10,136,904

ANKLE REPLACEMENT SYSTEM AND METHOD

Wright Medical Technology...

1. A surgical device, comprising:a body including a handle disposed at a first end and a locking protrusion extending in a direction away from a longitudinal direction of the body, the locking protrusion defining an opening and defining a hole that extends parallel to the longitudinal direction of the body;
a locking tab slidably received within the opening defined by the locking protrusion, the locking tab defining an aperture having first and second portions, the first portion being narrower than the second portion, the locking tab being sized and configured to be received within the opening defined by the locking protrusion of the body;
a pair of spaced apart rails configured to be disposed along a length of the body; and
a plunger rod sized and configured to be received slidably within a threaded hole defined by the handle, the aperture defined by the locking tab, and the hole defined by the locking protrusion, wherein the plunger rod comprises a handle at a proximal end and a shoulder having an enlarged diameter along a length of the plunger rod with a threaded portion adjacent to the shoulder, the threaded portion configured to engage the threaded hole defined by the handle, the plunger rod further comprising a reduced diameter region adjacent to a distal end of the plunger rod, the reduced diameter region having a diameter that is sized and configured to be received within the first portion of the aperture defined by the locking tab for locking the plunger rod in a retracted position,
wherein the surgical device is configured to be coupled releasably to a first implant component and to guide a second implant component into position with respect to the first implant component.

US Pat. No. 10,136,903

TOURNIQUET AND METHOD THEREOF HAVING COMPLIANCE LOGGING AND ALERT FEATURES, AND A SYSTEM THEREOF

Patrick James Lynch, Haw...

1. A tourniquet for blood constriction using a strap and a clasp connected to the strap, which is adjustably configured, and communicable with an external communication apparatus configured to transmit a logging confirmation signal to the tourniquet confirming a successful logging of compliance, the tourniquet comprising:a controller;
an indicator connected to the controller;
a first sensor connected to the controller; and
a housing containing the controller and the first sensor,
wherein the housing includes a receptacle configured to receive the clasp,
wherein the first sensor is configured to output a first signal when the clasp is inserted into the receptacle, and
wherein the controller comprises:
a first communication interface configured to communicate with the external communication apparatus;
a memory; and
a processor configured to execute:
a first determining task that determines whether the clasp has been inserted in the receptacle based on whether the first signal is received;
a first communication task that controls the first communication interface to initiate communication with the external communication apparatus upon the first determining task determining that the clasp has been inserted; and
an alerting task that controls the indicator to alert a user confirming whether the compliance has been satisfied.

US Pat. No. 10,136,899

CLAMP FOR USE WITH A CUTTING DEVICE

PRICE INVENA APS, Copenh...

1. A clamp comprising:a first leg having an inner face comprising a clamping bed,
a second leg attached at one end to the first leg at one end of said clamping bed by a resilient hinge by which the legs are sprung apart, said second leg having an inner face comprising a clamping bed extending part of the length of the inner face of said second leg from the hinge attached end of said second leg, and a recessed section extending from the clamping bed of said second leg to an opposite end of said second leg;
a third leg attached to said first leg at an opposite end of said clamping bed of the first leg by a resilient hinge by which the third and first legs are sprung apart, said third leg comprising a clamping bed extending the length of an inner face of said third leg, and a contact section on an outer face of said third leg;
wherein said first leg, said second leg and said third leg together form a cavity capable of receiving an object to be clamped,
wherein pressing said second leg towards the first leg against the resilience of the hinge joining them causes said recessed section of the second leg to contact said contact section on said third leg such that said third leg is pressed towards the first leg against the resilience of the hinge joining them,
wherein said recessed section is recessed such that said third leg fits into said recessed section when said clamp is closed,
wherein the clamping beds of said second and third legs together form a contiguous clamping bed for clamping a received object against the clamping bed of the first leg when said clamp is closed, and
wherein said first leg is parallel to said second and third legs when said clamp is closed.

US Pat. No. 10,136,897

EXPANDABLE VASO-OCCLUSIVE DEVICES HAVING SHAPE MEMORY AND METHODS OF USING THE SAME

Boston Scientific Scimed,...

1. A vaso-occlusive device comprising an elongated device portion and one or more expandable components which comprise a shape memory material and which expand laterally outward from the elongated device portion upon being subjected to an increase in temperature from below a thermal transition temperature of the shape memory material to above the thermal transition temperature of the shape memory material.

US Pat. No. 10,136,891

NATURALLY DERIVED BIOABSORBABLE POLYMER GEL ADHESIVE FOR RELEASABLY ATTACHING A STAPLE BUTTRESS TO A SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

11. A surgical stapler end effector, the end effector comprising:(a) a staple cartridge, wherein the staple cartridge comprises a deck;
(b) an anvil, wherein the anvil is movable from an open position toward the staple cartridge to reach a closed position, wherein the anvil includes an underside;
(c) a buttress assembly, wherein the buttress assembly comprises:
(i) a buttress body, and
(ii) an adhesive material, wherein the adhesive material is configured to removably secure the buttress body to the deck of the staple cartridge or the underside of the anvil; and
(d) a retainer, wherein the retainer is configured to releasably hold the buttress body and wherein the retainer includes an injection port that is configured to receive a syringe needle to thereby permit injection of the adhesive.

US Pat. No. 10,136,890

STAPLE CARTRIDGE COMPRISING A VARIABLE THICKNESS COMPRESSIBLE PORTION

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:an anvil, comprising a longitudinal row of first forming pockets and a longitudinal row of second forming pockets;
a firing member comprising a first cam and a second cam, wherein said first cam comprises a resilient pad, and wherein said second cam is configured to engage said anvil;
a staple cartridge, wherein said staple cartridge is movable relative to said anvil between a first position and a second position, and wherein said staple cartridge comprises:
a cartridge body, comprising:
a deck, comprising:
a longitudinal slot;
a first deck surface positioned on a first side of said longitudinal slot; and
a second deck surface positioned on a second side of said longitudinal slot;
a bottom portion positioned opposite said deck;
a proximal end;
a distal end;
a longitudinal row of first staple cavities extending between said proximal end and said distal end, wherein said first forming pockets are positioned relative to said first staple cavities when said staple cartridge is in said second position; and
a longitudinal row of second staple cavities extending between said proximal end and said distal end, wherein said second forming pockets are positioned relative to said second staple cavities when said staple cartridge is in said second position, and wherein each said first staple cavity and said second staple cavity comprises an opening in said deck;
a metal support extending under said bottom portion, wherein said metal support comprises a bottom cam surface configured to be engaged by said first cam of said firing member to position said cartridge body relative to said anvil;
a plurality of first staple drivers movable between an unfired position and a fired position, wherein each said first staple driver comprises a first support cradle, and wherein a first distance is defined between each said first support cradle and a said first forming pocket when said first staple drivers are in said unfired position;
a plurality of second staple drivers movable between an unfired position and a fired position, wherein each said second staple driver comprises a second staple support cradle, wherein a second distance is defined between each said second support cradle and a said second forming pocket when said second staple drivers are in said unfired position, and wherein said first distance is different than said second distance;
a plurality of first staples, wherein each said first staple is positioned in a said first staple cavity and supported by a said first support cradle, and wherein said first staples comprise a first unformed height;
a plurality of second staples, wherein each said second staple is positioned in a said second staple cavity and supported by a said second support cradle, wherein said second staples comprise a second unformed height, and wherein said first unformed height is different than said second unformed height;
a first tissue thickness compensator, wherein said first tissue thickness compensator comprises polyglycolic acid, wherein said first tissue thickness compensator extends across said longitudinal slot between said first deck surface and said second deck surface, wherein said first tissue thickness compensator comprises a first portion on a first side of said longitudinal slot and a second portion on said first side of said longitudinal slot, wherein said first portion is positioned closer to said longitudinal slot than said second portion, wherein said first portion is aligned with said first staple cavities and is configured to be captured within said first staples along with tissue having a variable thickness, wherein said second portion is aligned with said second staple cavities and is configured to be captured within said second staples along with tissue having a variable thickness, and wherein said first portion is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a first proximal anchor; and
a first distal anchor, wherein said first proximal anchor and said first distal anchor are configured to releasably hold said first tissue thickness compensator to said cartridge body, and wherein said first proximal anchor and said first distal anchor are configured to be incised to release said first tissue thickness compensator from said cartridge body;
a second tissue thickness compensator, wherein said second tissue thickness compensator comprises polyglycolic acid, wherein said second tissue thickness compensator is configured to be captured within said first staples and said second staples along with the tissue having a variable thickness, and wherein said second tissue thickness compensator is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a second proximal anchor;
a second distal anchor, wherein said second proximal anchor and said second distal anchor are configured to releasably hold said second tissue thickness compensator to said anvil, and wherein said second proximal anchor and said second distal anchor are configured to be incised to release said second tissue thickness compensator from said anvil; and
a joint configured to rotatably connected said staple cartridge to said surgical instrument.

US Pat. No. 10,136,889

SYSTEMS AND METHODS FOR CONTROLLING A SEGMENTED CIRCUIT

Ethicon LLC, Guaynabo, P...

1. A powered surgical instrument, comprising:a housing;
a shaft extending from said housing;
an end effector extending from said shaft, wherein said end effector is configured to perform at least one end effector function;
a power source;
a segmented circuit configured to control said powered surgical instrument, wherein said segmented circuit comprises:
a processor segment; and
a motor segment comprising a motor;
a voltage converter configured to supply a first voltage from said power source to said processor segment and a second voltage from said power source to said motor segment, wherein said first voltage and said second voltage are different;
a current sensor configured to measure current within said motor segment; and
a boost converter configured to increase said first voltage to said processor segment when said current exceeds a predetermined value in said motor segment.

US Pat. No. 10,136,887

DRIVE SYSTEM DECOUPLING ARRANGEMENT FOR A SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. A surgical end effector, comprising:a drive system, comprising:
a proximal assembly comprising a first translatable element, wherein a first aperture is defined in the first translatable element; and
a distal assembly comprising a second translatable element, wherein the second translatable element is releasably coupled to the first translatable element, and wherein a second aperture is defined in the second translatable element;
a pin removably positioned in the first aperture and the second aperture; and
a housing, wherein the drive system is positioned within the housing, wherein the pin is accessible from outside of the housing, wherein the proximal assembly is configured to receive a drive motion from a motor, and wherein the pin is configured to transfer the drive motion from the proximal assembly to the distal assembly when the pin is positioned in the first aperture and the second aperture.

US Pat. No. 10,136,884

METHOD AND APPARATUS FOR ATTACHING TISSUE TO BONE, INCLUDING THE PROVISION AND USE OF A NOVEL KNOTLESS SUTURE ANCHOR SYSTEM, INCLUDING A RETRACTABLE SHEATH

Pivot Medical, Inc., Sun...

1. Apparatus for securing a first object to a second object, the apparatus comprising:an anchor, the anchor comprising:
an elongated body having a distal end, a proximal end, and a lumen extending between the distal end and the proximal end, the lumen comprising a distal section and a proximal section, the distal section of the lumen having a wider diameter than the proximal section of the lumen;
a window extending through the side wall of the elongated body and communicating with the lumen, the window being disposed in the vicinity of an intersection between the distal section of the lumen and the proximal section of the lumen and being sized to receive a first object therein;
an elongated element extending through the lumen of the elongated body, the elongated element comprising a proximal end and a distal end; and
a locking element mounted to the distal end of the elongated element and disposed in the distal section of the lumen;
whereby, when the elongated body is disposed in a second object, and a first object extends through the window, and the locking element is thereafter moved proximally, proximal movement of the locking element causes the elongated body to capture the first object to the elongated body, whereby to secure the first object to the second object; and
an inserter, the inserter comprising:
a handle;
a shaft having a distal end and a proximal end, with a lumen extending therebetween, the proximal end of the shaft being mounted to the handle and the distal end of the shaft being configured to releasably engage the elongated body;
a retractable sheath disposed movably coaxially about the shaft; and
a movable tab mounted to the proximal end of the retractable sheath for moving the retractable sheath relative to the shaft.

US Pat. No. 10,136,883

METHOD OF ANCHORING A SUTURE

VentureMD Innovations, LL...

1. A method of repairing soft tissue adjacent a shoulder joint comprising:producing a bone tunnel into a bone, the bone tunnel having at least first and second openings at an exterior surface of the bone;
securing a first suture portion and a second suture portion to soft tissue;
positioning the first suture portion so that the first suture portion extends from the soft tissue to the first opening, then through the first opening, and then through the bone tunnel;
positioning the second suture portion so that the second suture portion extends, outside of the bone tunnel, from the soft tissue;
passing the first suture portion through a first transverse anchor passage in an anchor, the anchor comprising a proximal end and a distal end, the first transverse anchor passage extending transversely into the anchor at the distal end and a second transverse anchor passage extending transversely into the anchor at the proximal end;
passing the second suture portion through the second transverse anchor passage in the anchor;
inserting the anchor into the bone tunnel through the second opening; and
advancing a locking member in sliding translation along a path inside the anchor to compress the first and second suture portions between the locking member and the anchor to secure the first and second suture portions relative to the bone tunnel and the anchor, the first and second suture portions being positioned within the bone tunnel when the first and second suture portions are secured with the locking member, such that the first transverse anchor passage through the distal end substantially aligns with the first opening of the bone tunnel when the first suture portion is secured.

US Pat. No. 10,136,882

SPINAL SURGERY DISTRACTION WITH AN INTEGRATED RETRACTOR

GLOBUS MEDICAL, INC., Au...

1. A surgical method comprising:removing a portion of a disc from a disc space in a patient via an anterior approach;
performing a surgical distraction on vertebrae adjacent the disc space by inserting a combined distractor and retractor assembly in the disc space, wherein the combined distractor and retractor assembly comprises a distractor portion that is mated to a retractor portion; and
removing the distractor portion from the disc space while keeping the retractor portion in the disc space;
wherein the retractor portion is planar.

US Pat. No. 10,136,881

LAPAROSCOPIC RETRACTOR DEVICES

Mayo Foundation for Medic...

1. A laparoscopic retractor device comprising:a handle;
an elongate shaft with a proximal end portion that is attached to the handle, the shaft extending from the handle and terminating at a distal free end portion, the shaft defining a first lumen;
an elongate shaft linkage disposed within the first lumen, the shaft linkage having a proximal end and a distal end;
a first actuator located at the handle and coupled to the proximal end of the shaft linkage;
an expandable portion including: (i) a distal end portion coupled to the distal free end portion of the shaft and (ii) a proximal end portion coupled to the distal end of the shaft linkage, wherein moving the actuator causes the expandable portion to move radially outward from the shaft or radially inward toward the shaft; and
a sheath with a lumen therethrough, at least a portion of the shaft being disposed within the lumen, the sheath being slidable distally and proximally along the shaft.

US Pat. No. 10,136,879

SYSTEM AND METHOD FOR NON-CONTACT ELECTRONIC ARTICULATION SENSING

Covidien LP, Mansfield, ...

1. A surgical instrument, comprising:a handle portion;
a body portion extending distally from the handle portion and defining a first longitudinal axis;
an articulation tool assembly defining a second longitudinal axis and having a proximal end, the articulation tool assembly disposed at a distal end of the body portion and being movable from a first position in which the second longitudinal axis is substantially aligned with the first longitudinal axis to at least a second position in which the second longitudinal axis is disposed at an angle with respect to the first longitudinal axis;
an articulation mechanism configured to articulate the articulation tool assembly, the articulation mechanism including:
an articulation link mechanically engaged to the articulation tool assembly; and
an articulation knob mechanically engaged to the articulation link, wherein rotational motion of the articulation knob is translated into articulation movement of the articulation tool assembly through the articulation link; and
an articulation sensor assembly including:
a photo sensor disposed in spaced relation to the articulation link and configured to detect light reflected from the articulation link, the photo sensor configured to transmit a sensor signal; and
a microcontroller configured to determine an articulation angle of the articulation tool assembly based on the sensor signal.

US Pat. No. 10,136,878

AUTOMATIC DEVICE AND KIT FOR INSERTING A CANNULA TO A PREDETERMINED DEPTH WITHIN A BONE, IRRESPECTIVE OF THE THICKNESS OF THE TISSUE ABOVE THE BONE

WAISMED LTD., Herzliya (...

1. An automatic device for causing penetration of a stylet and cannula to a predefined depth ? within a bone, said depth ? being irrespective of a thickness of tissue above the bone, said device comprising:a) a trigger unit for activating the device;
b) a barrel;
c) a probe unit positioned within said barrel which is driven by a secondary spring, said probe unit comprises one or more probing needles at a distal end, and an anvil at a proximal end for defining an end of movement location for a hammer unit;
d) said hammer unit which is driven by a main spring and comprises a stylet which is longer than said one or more probing needles at its distal end, a core at its proximal end, and a piston between said core and stylet;
e) a cannula within which said stylet is inserted; and
f) one or more grasping units;
wherein when said hammer unit is positioned at said end of movement location, a tip of said stylet is located a distance ? farther in a distal direction from respective ends of said probing needles,
wherein said secondary spring, when released in response to activation of said trigger unit, is configured to push said one or more probing needles of said probe unit toward the bone, up to a point of contact with a surface of the bone,
wherein said one or more grasping units are configured to grasp the anvil of said probe unit, upon contact between said one or more probing needles and the bone surface,
wherein said main spring, when released in response to the activation of said trigger unit, is configured to push said hammer unit to said end of movement location and thereby cause penetration of said cannula to a depth of ? within the bone.

US Pat. No. 10,136,877

ULTRASOUND DIAGNOSIS APPARATUS AND IMAGE PROCESSING APPARATUS

Toshiba Medical Systems C...

1. An ultrasound diagnosis apparatus, comprising:processing circuitry configured to
generate three-dimensional image data based on reflected-wave data received by an ultrasound probe,
generate a two-dimensional tomographic image using the three-dimensional image data,
set a value of an image quality adjusting parameter used for generating a virtual endoscopic image so that a position of an internal wall of a lumen in the three-dimensional image data matches a corresponding position of the internal wall of the lumen in the two-dimensional tomographic image or so that a distance between two points on opposing sides of the internal wall of the lumen in the three-dimensional image data is equal to a corresponding distance between two points set in the two-dimensional tomographic image;
generate the virtual endoscopic image by projecting an inside of the lumen from a predetermined viewpoint and using the value of the set image quality adjusting parameter; and
cause a predetermined display to display the virtual endoscopic image.

US Pat. No. 10,136,875

ULTRASONIC DIAGNOSTIC APPARATUS AND ULTRASONIC DIAGNOSTIC METHOD

Konica Minolta, Inc., To...

1. An ultrasonic diagnostic apparatus that decides a type of a tumor contained in a specimen, the apparatus comprising:an image forming unit that forms an ultrasonic image corresponding to an echo signal received from the specimen after administration of a contrast medium;
a feature value calculating unit that classifies each of a plurality of pixel regions contained in a tumor region including the tumor in the ultrasonic image into a low-luminance region, or a high-luminance region having higher luminance than the luminance of the low-luminance region, and calculates, based on a difference between a variance at a position of the low-luminance region and a variance at a position of the high-luminance region, a ring level indicating a degree of a ring shape of an image of the tumor region, the ring shape in which a luminance value of a central portion is lower than a luminance value of a peripheral portion surrounding the central portion; and
a type deciding unit that decides the type of the tumor based on the ring level.

US Pat. No. 10,136,873

RADIOGRAPHIC IMAGE PROCESSING DEVICE, METHOD, AND RECORDING MEDIUM

FUJIFILM Corporation, Mi...

1. A radiographic image processing device comprising:at least one hardware processor configured to implement:
a frequency decomposition unit for performing frequency decomposition for a first radiographic image which is captured by irradiating a subject with radiation and acquiring a plurality of band images indicating a plurality of frequency components of the first radiographic image;
a scattered radiation removal unit for calculating a scattered radiation component that is caused by the subject and is included in a second radiographic image of the subject which has a linear relationship with an amount of radiation, using the second radiographic image, and removing the scattered radiation component from the second radiographic image to acquire a scattered-radiation-removed radiographic image;
a conversion function determination unit for determining a conversion function for converting at least one of the band images according to the scattered radiation component included in the second radiographic image;
a conversion unit for converting the at least one band image, using the conversion function, and generating a converted band image; and
a reconstruction unit for reconstructing the scattered-radiation-removed radiographic image and the converted band image to acquire a processed radiographic image,
wherein the first radiographic image has a pixel value that has a linear relationship with a logarithmic amount of radiation, and
wherein the second radiographic image is obtained by performing inverse logarithmic conversion for the first radiographic image.

US Pat. No. 10,136,872

DETERMINATION OF AN X-RAY IMAGE DATA RECORD OF A MOVING TARGET LOCATION

1. A method for determining an x-ray image data record of a target location of a patient subjected to a movement using an x-ray device, the method comprising:recording a plurality of component images of the target location using an image exposure time;
registering the plurality of component images with one another;
determining one or more quality values related to the movement of the target for each component image of the plurality of component images, the one or more quality values including at least a motion speed calculated as a comparison between a spread function of at least two or more of the plurality of component images and a reference spread function of the x-ray device;
selecting as a function of the one or more quality values a contribution of one or more basic images of the plurality of component images; and
combining the one or more component images into the x-ray image data record as a function of the selected contribution of the one or more component images.

US Pat. No. 10,136,871

EXTREMITY IMAGING FOR ANIMALS

Carestream Health, Inc., ...

1. An apparatus for radiographic imaging of an animal, the apparatus comprising:a support base having a top surface to support a four legged animal standing thereon;
a moveable x-ray source disposed within a source housing and mechanically attached to the support base; and
a digital radiographic detector mechanically attached to the support base, wherein the source housing and the detector extend upward substantially perpendicular to, and above, the top surface of the support base, and wherein the x-ray source and the detector are configured to capture a radiographic image of at least one foreleg or hind leg of the standing animal,
wherein the source and the detector are attached to separate, concentric, moveable portions of the top surface of the support base, each of the moveable portions of the top surface of the support base comprising a ring shape coplanar with a plane of the top surface of the support base.

US Pat. No. 10,136,870

EXTREMITY IMAGING FOR ANIMALS

Carestream Health, Inc., ...

1. An apparatus for radiographic imaging of an animal, the apparatus comprising:a floor to support an animal standing on its legs;
a moveable x-ray source disposed above a surface of the floor within a source housing and mechanically attached to a rotation mechanism; and
a digital radiographic detector disposed below the surface of the floor and mechanically attached to the rotation mechanism, wherein the source housing remains stationary, and wherein the x-ray source and the detector are configured to revolve around at least one extremity of the animal to capture at least one radiographic image thereof.

US Pat. No. 10,136,868

FAST DUAL ENERGY FOR GENERAL RADIOGRAPHY

General Electric Company,...

1. A system, comprising:an X-ray source configured to generate X-rays directed toward an object, wherein the X-ray source is to: (i) generate a first energy X-ray pulse, (ii) switch to generate a second energy X-ray pulse, and (iii) switch back to generate another first energy X-ray pulse, wherein the second energy X-ray pulse is associated with higher voltage level as compared to the first energy X-ray pulses;
a detector associated with multiple image pixels, the detector including, for each pixel:
an X-ray sensitive element to receive X-rays,
a first storage element and associated switch to capture information associated with the first energy X-ray pulses, and
a second storage element and associated switch to capture information associated with the second energy X-ray pulse; and
a controller to synchronize the X-ray source and detector.

US Pat. No. 10,136,867

RADIOLOGICAL IMAGING SYSTEM WITH IMPROVED INTERNAL MOVEMENT

IMAGINALIS SRL, Sesto Fi...

1. A radiological imaging system, comprising:a bed;
a load-bearing structure connected to the bed and configured to support the bed; and
a gantry connected to the load-bearing structure, the gantry defining a main axis of expansion, the gantry having a source configured to emit radiation, a detector with a sensitive surface configured to detect the radiation, an internal inner guide configured to rotate the detector around the main axis of expansion defining an inner sliding trajectory, and an internal outer guide configured to rotate the source around the main axis of expansion defining an outer sliding trajectory, wherein the distance from the source to the main axis of expansion is greater than the distance from the detector to the main axis of expansion, and the gantry including a casing housing the source, the detector, the internal inner guide, and the internal outer guide,
wherein the casing includes a fixed arched module, a first mobile arched module, and a second mobile arched module.

US Pat. No. 10,136,866

RADIATION IRRADIATION DEVICE

FUJIFILM Corporation, To...

1. A radiation irradiation device comprising:a radiation generation unit that generates radiation;
an arm part having one end to which the radiation generation unit is attached;
a support member having one end to which the other end of the arm part is connected so as to be rotationally movable;
a body part to which the other end of the support member is connected; and
a leg part on which the body part is placed,
wherein in a case where a side toward which the arm part extends from the body part during use of the device is defined as a front side, the leg part includes a first caster which is provided on the front side of a bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported and a second caster which is provided on a rear side of the bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported, and
wherein a diameter of the wheel of the second caster is greater than a diameter of the wheel of the first caster, and a gravity center position of the entire device is closer to the second caster side than a center between the first caster and the second caster in a state where the arm part is rotationally moved until the radiation generation unit is located at a vertically lowermost position.

US Pat. No. 10,136,864

X-RAY COLLIMATOR SIZE AND POSITION ADJUSTMENT BASED ON PRE-SHOT

KONINKLIJKE PHILIPS N.V.,...

1. An X-ray apparatus for image acquisition, comprising:an X-ray source configured to generate X-ray radiation for image acquisition of an object;
a collimator comprising at least one moveable shutter, the collimator being configured to collimate the X-ray radiation into a radiation cone, said radiation cone irradiating the object at a region of interest when acquiring an image;
a portable radiation detector configured to register the X-ray radiation after passage through the object; and
a field-of-view corrector configured to receive, in a pre-shot imaging phase, a scout image (SI) acquired by the portable radiation detector with a tentative setting of the collimator, the pre-shot imaging phase causing a low dosage radiation cone to impinge on the portable radiation detector, the low dosage radiation cone having in an image plane of the portable radiation detector a first cross section being smaller than a surface area of the portable radiation detector,
the field-of-view corrector being further configured to use said scout image to establish field-of-view correction information for a subsequent imaging phase, the field of view correction information including collimation correction information for determining a corrected setting of the collimator,
wherein, in the subsequent imaging phase, the corrected setting of the collimator results in a high dosage radiation cone impinging on the portable radiation detector, the high dosage radiation cone providing a higher dosage of radiation than the low dosage radiation cone, and the high dosage radiation cone having, in the image plane of the portable radiation detector, a second cross section that is larger than the first cross section and the high dosage radiation cone i) being essentially coextensive with the surface area of the portable radiation detector or ii) being a symmetric enlargement of the first cross section and extending in its entirety within the surface area of the portable radiation detector.

US Pat. No. 10,136,862

METHOD OF SONIFYING BRAIN ELECTRICAL ACTIVITY

The Board of Trustees of ...

1. A method of sonifying brain signals using a digital processor system that comprises at least one processing unit, the method comprising:filtering, with a front-end module coupled to the digital processor system, a continuous time-domain sensor signal representing brain activity of a subject obtained from at least one sensor in order to generate a filtered continuous time-domain sensor signal;
producing a continuous time-domain signal representing the brain activity of the subject from the filtered continuous time-domain sensor signal using the digital processor system, the continuous time-domain signal having a time varying signal value;
concurrently generating a plurality of continuously time-varying acoustic parameters from the continuous time-domain signal using the digital processor system, the plurality of continuously time-varying acoustic parameters including a vowel-control parameter, an intensity-control parameter, and a pitch-control parameter, wherein at least three of the parameters in the plurality of continuously time-varying acoustic parameters are continuously modulated in proportion with at least the continuous time varying signal value of the time-domain signal during concurrent generation;
driving, with the digital processor system, an audio synthesizer using the concurrently generated plurality of continuously time-varying acoustic parameters, including the vowel-control parameter, the intensity-control parameter, and the pitch-control parameter, to produce a representation of an acoustic signal corresponding to the brain activity of the subject represented by the continuous time-domain signal;
performing continuous audio playback of the representation of the acoustic signal using the digital processor system, wherein performing the continuous audio playback comprises audibly providing, with at least one speaker, the representation of the acoustic signal for diagnosis and/or treatment of a condition of the subject.

US Pat. No. 10,136,859

SYSTEM AND METHOD FOR OUTPATIENT MANAGEMENT OF CHRONIC DISEASE

1. An outpatient ambulatory patient worn apparatus for managing chronic lung disease comprising:a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data, said plurality of sensors including at least one oximeter, a respiratory rate sensor, and at least one activity or motion sensor, at least said oximeter, said at least one oximeter, said respiratory rate sensor, and said at least one activity or motion sensor continuously operative to measure said plurality of physiological data in an outpatient setting during activities of daily living comprising rest, exertion, and sleep;
a central monitoring unit (CMU) communicatively coupled to said plurality of sensors and to an interface device, said CMU comprising a computer, and said CMU to be worn by the patient in said outpatient setting during activities of daily living, said CMU programmed to record concurrently a set of time stamped primary data comprising measurement data from each of said plurality of sensors to a non-volatile memory at a predetermined interval for one or more epochs of time, and to categorize at an acquisition rate or some multiple of the acquisition rate each recorded measurement of each of said plurality of sensors stored in said set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, said predominate activity type selected from a plurality of activity types including rest, exertion, and sleep; and
a generate report process running on said CMU to provide at least one or more reports in real time including at least an indication or determination of whether a chronic lung disease treatment is needed by the patient based on said set of activity type stamped data.

US Pat. No. 10,136,858

METHOD FOR INSPECTING PRESSURE PULSE WAVE SENSOR AND METHOD FOR MANUFACTURING PRESSURE PULSE WAVE SENSOR

OMRON HEALTHCARE Co., Ltd...

1. A method for inspecting a pressure pulse wave sensor which includes a sensor chip and a substrate, the sensor chip including a pressure-sensitive element array constituted by a plurality of pressure-sensitive elements arranged in one direction, the sensor chip put into use so that a pressure-sensitive face of the sensor chip where the pressure-sensitive element array is formed is pressed against a body surface of a living body in a state in which the one direction intersects with a traveling direction of an artery of the living body, the sensor chip fixed to the substrate, whereinthe substrate includes a through hole and a substrate-side terminal portion,
the sensor chip includes a recess which is recessed in a direction perpendicular to the pressure-sensitive face and on an opposite side to the pressure-sensitive face, and the pressure-sensitive element array is formed on the pressure-sensitive face in a portion of the sensor chip whose thickness is reduced in the perpendicular direction due to the recess, and
the sensor chip further includes a chip-side terminal portion which is electrically connected to the pressure-sensitive element array and which is provided at one or each of opposite ends of the pressure-sensitive element array extending in the one direction,
the method comprising:
bonding and fixing the sensor chip onto the substrate so that the recess communicates with atmospheric air through only the through hole of the substrate;
connecting the substrate-side terminal portion of the substrate to which the sensor chip is bonded and fixed, and the chip-side terminal portion through an electrically conductive member;
covering the electrically conductive member with a protective member; and
performing characteristic evaluation about a variation among the plurality of pressure-sensitive elements of the sensor chip, after covering the electrically conductive member with the protective member, based on a signal outputted from the substrate-side terminal portion in a state in which air is sucked through the through hole of the substrate to thereby apply negative pressure to the pressure-sensitive face.

US Pat. No. 10,136,855

AUTOMATIC ADJUSTMENT OF HELMET PARAMETERS BASED ON A CATEGORY OF PLAY

INTERNATIONAL BUSINESS MA...

1. A method for automatic adjustment of helmet parameters based on a category of play, the method comprising:monitoring a plurality of sensors in a helmet;
determining the category of play for a user of the helmet based on data received from the plurality of sensors; and
automatically adjusting parameters of the helmet based on the category of play, wherein the parameters include at least one of a stiffness, a size and a shape of a padding of the helmet,
wherein a type of an adjustment and an amount of the adjustment are determined based on a model of expected risks for the category of play for the user.

US Pat. No. 10,136,854

STRETCHABLE THERMOELECTRIC MATERIAL AND THERMOELECTRIC DEVICE INCLUDING THE SAME

Samsung Electronics Co., ...

1. A thermoelectric material, comprising:a stretchable polymer; and
a thermoelectric structure and electrically conductive material that are mixed together in the stretchable polymer, the thermoelectric structure including a carbon-containing material, wherein
the carbon-containing material includes carbon nanotubes,
the carbon nanotubes are arranged in an array, and
lengths of the carbon nanotubes are parallel to each other.

US Pat. No. 10,136,853

CONTACTLESS SLEEP DISORDER SCREENING SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. A system configured to monitor a sleep session of a patient without making physical contact with the patient, the system comprising:a sound sensor configured to generate output signals that convey information related to sound originating from the patient in a sleeping environment;
a movement sensor comprising:
a light source configured to project a structured light pattern onto the patient which deforms when the patient moves; and
a detector configured to receive light reflected from the patient, the detector configured to generate output signals that convey information related to changes in the structured light pattern projected onto the patient caused by movement of the patient; and
one or more hardware processors configured by machine-readable instructions to:
receive and store data relating to the sound originating from the patient based on the information conveyed by the output signals from the sound sensor,
determine movement of the patient based on (1) a distance between the light source and the detector, and (2) a change in angle of reflected light from the structured light pattern received from an individual moving point on the patient, wherein images derived from the information related to changes in the structured light pattern are construed wherein an indication of motion vectors is provided, wherein the motion vectors indicate a direction and an amplitude of the movement of the patient, wherein the motion vectors facilitate segmentation of one or more body parts, and wherein information related to a mouth movement is determined based on the segmentation of the one or more body parts, and
determine a sleep disorder diagnosis based on the sound originating from the patient and the movement of the patient, wherein the one or more hardware processors are configured to determine parasomnia Bruxism based on the determined mouth movement.

US Pat. No. 10,136,851

INTEGRATED DEVICE TO MEASURE VARIATIONS IN NEUROMUSCULAR CONTROL WHEN TRACING DEFINED TARGET PATTERNS AND A SYSTEM AND METHOD OF USING THE INTEGRATED DEVICE

1. A device for measuring variations in neuromuscular control of a user, comprising:an integrated device, including:
a computing device configured to be held by the user;
a pointing device attached to, or integrated with the computing device, the pointing device including an end portion;
the computing device configured to detect three-dimensional movement data of the integrated device relative to a particular pattern predefined in the computing device while the user is tracing the pattern;
wherein the pointing device is configured for the end portion to be pointed at said pattern at a predefined distance from said pattern to trace said pattern, without the end portion physically touching the pattern.

US Pat. No. 10,136,848

DEVICE AND SYSTEM OF BLOOD COLLECTION, AND METHOD THEREOF

Winnoz Technology, Inc., ...

1. A device for collecting a blood sample, comprising:a collection unit comprising:
a top window;
a top surface;
a channel communicated with the top window;
at least one capillary tube having a top end adjacent to the top window;
wherein a distance between the top end of the at least one capillary tube and the top surface of the collection unit is in a range of 1.0 mm to 5.0 mm, such that the top end of the at least one capillary tube is used to contact with a blood drop from a puncture to continuously draw the blood flowing inside or along the at least one capillary tube into a storage unit by disrupting a surface tension of the blood drop, and
a vacuum connector communicated with the channel, extended outwardly from the collection unit, and connected to a pressure control unit to remove air from the channel and create an alternating negative pressure in the channel; and
the storage unit disposed under the collection unit.

US Pat. No. 10,136,847

MITIGATING SINGLE POINT FAILURE OF DEVICES IN AN ANALYTE MONITORING SYSTEM AND METHODS THEREOF

Abbott Diabetes Care Inc....

1. A computer-implemented method for mitigating single point failure of at least one device in an analyte monitoring system, comprising:providing a request, from a first device to a second device, that a functionality check of one or more components of a third device be performed, wherein the functionality check includes communicating, from the third device to the second device, data related to results of the functionality check;
receiving, at the first device, the data related to the results of the functionality check from the second device;
determining, by the first device, that the one or more components of the third device is not functioning in accordance with at least one predetermined criterion; and
providing, to the second device, a request from the first device that an alarm function be initiated to alert a user that the one or more components of the third device is not functioning in accordance with the at least one predetermined criterion.

US Pat. No. 10,136,845

DEVICES, SYSTEMS, AND METHODS ASSOCIATED WITH ANALYTE MONITORING DEVICES AND DEVICES INCORPORATING THE SAME

ABBOTT DIABETES CARE INC....

1. An apparatus for receiving analyte data from an in vivo analyte sensing device, comprising:a housing;
a display mounted on the housing;
an input component;
a test strip port;
a processor mounted in the housing; and
a memory storing instructions which, when executed by the processor, cause the processor to:
navigate from a current user interface screen on the display to a home screen in response to a press of the input component by a user unless a test strip is in the test strip port and a test strip result has not yet been computed;
cause display of the home screen, wherein the home screen includes an indication of the time remaining until the in vivo analyte sensing device expires; and
cause display of received analyte information,
wherein the instructions, when executed by the processor, cause the processor to render inactive the press of the input component by the user to navigate from the current user interface screen on the display to the home screen if the test strip is in the test strip port and the test strip result has not yet been computed.

US Pat. No. 10,136,842

FOOTWEAR APPARATUS WITH TECHNIQUE FEEDBACK

1. A footwear apparatus comprising:a sensor in the footwear apparatus positioned to monitor an activity technique of a user when the footwear apparatus is joined with a foot of the user, and
a feedback generator arranged to produce a haptic communication to the user in response to detecting a pattern in the activity technique, the haptic communication arranged to cause at least some discomfort to the user, wherein the pattern includes a pronation element.

US Pat. No. 10,136,839

AIRWAY ADAPTOR

NIHON KOHDEN CORPORATION,...

1. An airway adaptor adapted to be attached to a mask, the mask adapted to be attached to a face of a living body, the airway adaptor comprising:an airway case;
an expired gas guiding portion which is connected to the airway case to introduce a respiratory gas to the airway case;
a partition wall;
an elongated first passage adapted to introduce the respiratory gas from the expired gas guiding portion to the airway case; and
an elongated second passage adapted to discharge the respiratory gas from the elongated first passage, which has been introduced to the airway case and returned in the airway case without being communicated with the expired gas guiding portion, to outside of the airway case,
wherein the partition wall partitions the elongated first passage and the elongated second passage such that a portion of the elongated first passage is parallel to a portion of the elongated second passage,
wherein the respiratory gas in the portion of the elongated first passage flows in a first direction and the respiratory gas in the portion of the elongated second passage flows in a second direction opposite and in reverse with respect to the first direction,
wherein the airway case includes a respiratory gas flow path through which the respiratory gas passes, the respiratory gas flow path including:
the elongated first passage in which the respiratory gas flows in the first direction; and
the elongated second passage in which the respiratory gas flows in the second direction opposite and in reverse with respect to the first direction,
the elongated first passage and the elongated second passage being connected to each other in an opening of the airway case, and
wherein, when the mask is attached to the face of the living body, at least a part of the airway case that includes the opening in which the elongated first passage and the elongated second passage are connected is projected to an outside of a shell of the mask.

US Pat. No. 10,136,838

PERSONAL SPIROMETER

PMD Healthcare, Lansdale...

1. A hand-held spirometer for correlating test results with a medical condition, said spirometer comprising:a portable housing having handles configured for said user to grip said handles to hold said housing during use;
a display on a surface of said housing;
an airflow tube through said housing;
one or more air flow sensors associated with said airflow tube;
a processor in said housing;
memory operatively connected to said processor and configured with instructions to instruct the processor to perform the following steps:
determining and recording sequential lung performance values based on data from said air flow sensors over a period;
recording user data during said period, said user data comprising at least medical compliance;
correlating said sequential lung performance values and said user data over said period; and
displaying a relationship between said sequential lung performance data and said medical compliance over said period on said display; and wherein said relationship on said display comprises a plot of lung performance per increment of time during said period with an indication of medical compliance for each said increment of time during said period.

US Pat. No. 10,136,837

DEVICE AND METHOD FOR THE ANALYSIS OF THE AIR EXHALED BY A SUBJECT IN ORDER TO MEASURE THE BASAL METABOLISM THEREOF

COSMED S.r.l., Roma (IT)...

1. Device for the analysis of the air exhaled by a subject in order to measure basal metabolism of the subject, the device comprising:a main line, for passage of a sampling flow of the air exhaled by the subject,
a suction pump having a substantially constant flow rate, said pump being arranged downstream of the main line, for drawing said sampling air flow into the main line,
a mixing mini-chamber interposed in the main line upstream of the suction pump for accumulating or mixing with each other a plurality of air sampling flows exhaled by the subject within a number of respiratory cycles,
a by-pass line arranged in parallel to the mixing mini-chamber through which the air flow can flow without passing through said mixing mini-chamber,
a by-pass valve interposed in the main line downstream of the mixing mini-chamber and selectively displaceable in two different positions for causing the airflow through the main line to flow either through the mixing mini-chamber or through said by-pass line,
first sensor means for sensing the oxygen concentration and second sensor means for sensing the carbon dioxide concentration, said first and second sensor means being arranged in the main line between said by-pass valve and the suction pump, for measuring the oxygen concentration and the carbon dioxide concentration within the air flow through the main line downstream of the mixing mini-chamber,
a first switching valve for switching the suction inlet of the suction pump between a condition of connection to said first and second sensor means and a condition in which this connection is interrupted,
flow measuring means for detecting the flow rate of the air inhaled or exhaled by the subject, and
an electronic controller configured for:
receiving and processing signals emitted by said first sensor means of the oxygen concentration, by said second sensor means of the carbon dioxide concentration and by said flow measuring means so as to obtain a measurement of oxygen consumption and carbon dioxide production by the subject within a number of respiratory cycles,
wherein said device further comprises:
a first inlet connector connected to a system for taking a flow of air exhaled by a subject who breathes spontaneously,
a second inlet connector connected through a sampling line to a system for taking a flow of air exhaled by a subject undergoing assisted pulmonary ventilation,
a selection valve interposed in the main line upstream of the mixing mini-chamber for selectively connecting said first connector or said second connector to said main line,
said selection valve having an outlet connected to the main line, a first inlet connected to said first connector and the second inlet for connection to said second connector,
a calibration line, which receives a calibration flow, to be used for calibrating said first and second sensor means for sensing the oxygen concentration and the carbon dioxide concentration,
a second switching valve adapted to be switched between a sampling state and a calibration state, said switching valve being controlled by said electronic controller for selectively connecting said second inlet of said selection valve to said sampling line connected to said second connector or to said calibration line,
a plurality of selector valves distributed in series along said calibration line for selectively connecting the calibration line each time to one only among a plurality of auxiliary lines adapted to provide respective calibration data,
said electronic controller being configured so that, during normal operation of the device, the selection valve is switched for feeding to the main line either a sampling flow of the air exhaled by a subject who breathes spontaneously or by a subject which undergoes assisted pulmonary ventilation, said by-pass valve being in a position causing the airflow to pass through said mixing mini-chamber so that said electronic controller is able to perform said processing in order to obtain said measurement of the oxygen consumption and the carbon dioxide production by the subject within a number of respiratory cycles,
said electronic controller being further programmed for automatically starting, upon switching on the device, a self-calibration stage of the device in which:
the second switching valve communicates said second connector of said selection valve to said calibration line while the selection valve communicates its second inlet to said main line, so that the main line enters into communication with said calibration line,
said electronic controller being configured so that in said self-calibration stage the by-pass valve is in a position which causes said sampling flow of the air exhaled by the subject to flow through said by-pass line, without passing through said mixing mini-chamber, whereby the self-calibration stage can be carried out immediately on the basis of the flow coming from said calibration line, without requiring a filling of said mixing mini-chamber.

US Pat. No. 10,136,834

NEURONAL RESONANCE MAGNETIC RESONANCE IMAGING METHOD

KOREA ADVANCED INSTITUTE ...

1. A magnetic resonance signal processing method for detecting a magnetic field oscillation signal, the method comprising:obtaining N pieces of MRI (magnetic resonance imaging) data by repeating a step of obtaining an MRI data with an MRI scheme using a gradient magnetic field pattern N number of times while changing relative phases between the gradient magnetic field pattern and the magnetic field oscillation signal; and
calculating a value related to an energy of a predetermined frequency component of an arranged signal produced by arranging the obtained N pieces of MRI data on a time-axis according to the relative phases,
wherein the N pieces of MRI data are K-space data or the N pieces of MRI data are MRI image data.

US Pat. No. 10,136,833

IMPLANTABLE RADIO-FREQUENCY SENSOR

ZOLL MEDICAL ISRAEL, LTD....

1. A diagnostic apparatus, comprising:a sealed case, comprising a biocompatible material and configured for implantation within a body;
a first antenna and a second antenna, each antenna configured to:
be implanted in the body in proximity to a target tissue,
generate and transmit radio frequency (RF) electromagnetic waves through the target tissue to the other antenna, and
output a signal in response to RF waves received from the other antenna; and
processing circuitry, which is contained within the case and is configured to receive and process the signal from each antenna so as to derive and output an indication of a characteristic of the target tissue.

US Pat. No. 10,136,832

REAL-TIME STIMULATION ARTIFACT SUPPRESSION FOR SIMULTANEOUS ELECTROPHYSIOLOGICAL ELECTRICAL STIMULATION AND RECORDING

THE REGENTS OF THE UNIVER...

1. An electrophysiological electrical stimulation and recording apparatus with stimulation artifact suppression, comprising:(a) a control circuit configured for controlling stimulus generation, artifact suppression and recording of a response to the generated stimulus;
(b) a current mode neural stimulator coupled to said control circuit, for amplifying an output from the control circuit to a recording/STI electrode;
(c) a first response amplification stage configured for amplifying the difference between a reference electrode and said recording/STI electrode as a measured stimulus response signal without amplifier saturation;
(d) a second response amplification stage configured for amplifying the difference between said measured stimulus response signal and a subtraction signal selected by said control circuit;
(e) wherein said control circuit is configured for:
(i) setting said subtraction signal to a fixed reference voltage;
(ii) generating a stimulus signal to said stimulus amplifier and storing an output from said second response amplification stage as a first artifact template;
(iii) calibrating the first artifact template by generating a stimulus signal to said stimulus amplifier while outputting said first artifact template as said subtraction signal to said second response amplification stage whose output is used to calibrate said first artifact template as a second artifact template; and
(iv) performing simultaneous stimulation and measurements by outputting said second artifact template as said subtraction signal to said second response amplification stage when outputting a stimulus signals to said stimulus amplifier connected to said recording/STI electrode;
(v) wherein subtraction of said second artifact template from the measured stimulus response signal results in removal of the artifacts from the measured stimulus response signal.

US Pat. No. 10,136,830

NEUROPHYSIOLOGICAL DATA ANALYSIS USING SPATIOTEMPORAL PARCELLATION

Elminda Ltd., Herzliya (...

1. A method of analyzing neurophysiological data recorded from a brain of a subject, the method comprising:recording the neurophysiological data by a plurality of measuring devices respectively placed at a plurality of different locations on the scalp of the subject,
operating a data processor for:
identifying activity-related features in the data;
parceling the data according to said activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain and corresponding to an extremum of the data and a spatiotemporal neighborhood defined as a spatial region in which said extremum is located and a time-interval during which said extremum occurs, wherein a size of said neighborhood is determined based on a property of said extremum;
storing said capsules in a memory;
comparing at least some of said defined capsules to at least one reference capsule;
estimating a brain function of the subject based on said comparison and;
generating on a display an output indicative of said brain function.

US Pat. No. 10,136,829

SYSTEMS AND METHODS FOR USING ELECTROPHYSIOLOGY PROPERTIES FOR CLASSIFYING ARRHYTHMIA SOURCES

St. Jude Medical, Cardiol...

1. A method for determining electrophysiology properties of tissue, the method comprising:acquiring electrical signal data from a plurality of electrodes of one or more catheters;
determining at least one electrode clique from the plurality of adjacent electrodes, wherein the at least one electrode clique comprises at least three adjacent electrodes;
computing local conduction velocity vectors for the at least one electrode clique;
determining at least one catheter orientation independent indicator from which to classify an arrhythmia source based on one or more of an angular dependence parameter associated with a flow field of the local velocity conduction vectors, an eccentricity parameter reflecting the uniformity of local conduction velocity, and divergence and curl-like sums or closed path integral parameters associated with the local conduction velocity vectors; and
displaying a rhythm classification responsive to catheter movement thereby facilitating identification of types and causes of arrhythmia disorders.

US Pat. No. 10,136,826

SYSTEM AND METHOD FOR DISTINGUISHING A CARDIAC EVENT FROM NOISE IN AN ELECTROCARDIOGRAM (ECG) SIGNAL

ZOLL MEDICAL CORPORATION,...

1. A wearable defibrillator comprising:at least one therapy pad for rendering treatment to a patient wearing the wearable defibrillator;
at least one sensing electrode for obtaining an electrocardiogram (ECG) signal from the patient;
a processing unit comprising at least one processor operatively coupled to the at least one therapy pad and the at least one sensing electrode; and
at least one non-transitory computer-readable medium comprising program instructions that, when executed by the at least one processor, causes the processing unit to:
obtain the ECG signal;
determine a transformed ECG signal based on the ECG signal;
extract at least one value representing at least one feature of the transformed ECG signal;
provide the at least one value to determine a score associated with the ECG signal, thereby providing an ECG-derived score;
compare the ECG-derived score to a predetermined threshold score determined by machine learning; and
provide an indication of a cardiac event based on the comparison of the ECG-derived score with the predetermined threshold score,
wherein the transformed ECG signal comprises a power spectral density (PSD) of the ECG signal, the PSD being determined by calculating a fast Fourier transform (FFT) of the ECG signal, and
wherein at least four features of the PSD are extracted and provided to the machine learning.

US Pat. No. 10,136,825

LONG-TERM IMPLANTABLE SILICON CARBIDE NEURAL INTERFACE DEVICE USING THE ELECTRICAL FIELD EFFECT

University of South Flori...

1. An implantable neural interface device, the device comprising:a control unit;
at least one substantially planar neural probe coupled to the control unit, each of the at least one substantially planar neural probes comprising;
at least one neural tissue stimulation device comprising at least one electrolyte insulator semiconductor capacitor (EISCap) having a cubic silicon carbide (3C—SiC) base and a biocompatible and chemically resistant gate insulator, wherein neural tissue in contact with the electrolyte insulator semiconductor capacitor (EISCap) forms a gate conductor to generate an electric field to stimulate the neural tissue at least partially surrounding the at least one substantially planar neural probe; and
at least one neural tissue stimulation receiving device comprising at least one field effect transistor having a cubic silicon carbide (3C—SiC) base, wherein neural tissue in contact with the at least one field effect transistor forms a gate conductor and wherein the at least one neural tissue stimulation receiving device receives ionic changes generated by the neural tissue resulting from the electric field stimulation by the at least one neural tissue stimulation device.

US Pat. No. 10,136,824

ARTERIAL SPIN LABELING (ASL) WITH MAGNETIC RESONANCE FINGERPRINTING (MRF)

Case Western Reserve Univ...

1. A method for performing arterial spin labeling (ASL) with magnetic resonance fingerprinting (MRF), comprising:selecting an ASL-MRF pulse sequence to apply to an object, where the ASL-MRF pulse sequence includes a labeling pulse and a control pulse;
controlling a magnetic resonance (MR) apparatus to apply the ASL-MRF pulse sequence to the object;
acquiring a nuclear magnetic resonance (NMR) signal evolution from the object, where the NMR signal evolution depends, at least in part, on a property of the arterial spins in the object;
selecting an entry in an MRF dictionary associated with the NMR signal evolution, and
simultaneously quantifying two or more properties of the arterial spins in the object based, at least in part, on the entry.

US Pat. No. 10,136,822

METHOD AND APPARATUS FOR NON-INVASIVELY DETECTING BLOOD VOLUME IMBALANCES IN A MAMMALIAN SUBJECT

Zynex Monitoring Solution...

1. An apparatus for noninvasively detecting blood volume changes in a mammalian subject, the apparatus comprising: a number of noninvasive sensors, communicable with the subject to obtain baseline and real time (current) physiologic value measurements from the subject; and at least one integrated circuit, operably connected with the sensors and configured to i) compute a real time (current) blood volume index from the physiologic value measurements wherein the blood volume index is derived from at least three physiological parameters selected from the group including heart rate, electrical body impedance, skin temperature, peripheral blood flow and skin humidity and wherein measurements of electrical body impedance, skin temperature, peripheral blood flow and skin humidity are taken at one or more extremities of the subject, and wherein the parameters are monitored by obtaining real time (current) value measurements for the parameters which are inputted into an algorithm which computes the real time (current) blood volume index based upon the differences between the baseline and real time (current) value measurements and wherein the algorithm includes coefficients for accurately weighting each parameter in the real time blood volume index, and wherein said algorithm for computing the real time (current) blood volume index=(100*(1?(((BINormalized?BIBaseline)/BIBaseline)*BICoefficient)?(((HRRealtime?HRBaseline)/HRBaseline*HRCoefficient)+(((PBFRealtime?PBFBaseline)/PBFBaseline*PBFCoefficient)?(((GSRRealtime?GSRBaseline)/GSRBaseline*GSRCoefficient)+(((STempRealtime?STempBaseline)/STempBaseline*STempCoefficient))) wherein BINormalized is peripheral bioimpedance normalized by removing known physiological drift, BICoefficient=0.725, HRCoefficient=0.145, PBFCoefficient=0.043, GSRCoefficient=0.014, and StempCoefficient=0.072, and ii) display the real time (current) blood volume index on a display of the apparatus, wherein the display is initially set to display a starting value blood volume index of 100 which indicates 100% of the subject's normal total blood volume, and wherein the displayed real time (current) blood volume index is capable of indicating a blood volume change in the subject as low as 10% of the subject's total blood volume.

US Pat. No. 10,136,821

IMAGE GENERATING APPARATUS, IMAGE GENERATING METHOD, AND PROGRAM

CANON KABUSHIKI KAISHA, ...

1. An apparatus for generating a photoacoustic image based on an acoustic wave caused by irradiation of light on an object, comprising:a determination unit configured to determine a propagation velocity of the acoustic wave; and
an image generation unit configured to generate the photoacoustic image based on the propagation velocity and a signal obtained by detecting the acoustic wave;
wherein the determination unit is configured to
set, based on an ultrasonic image obtained by transmitting and receiving an ultrasonic wave, a target position, and
determine, based on the signal corresponding to the target position, the propagation velocity.

US Pat. No. 10,136,820

METHOD TO VISUALIZE VERY EARLY STAGE NEOPLASM OR OTHER LESIONS

1. A treatment evaluation method comprisinganalyzing a liquid biopsy sample from a patient for the presence of at least one detectable biomarker of a lesion for which the patient has a family history of predisposition before there is any clinical manifestation or radiographic evidence of the lesion,
generating one or more anti-tumor antibodies based upon the at least one biomarker of the lesion detected in the liquid biopsy sample,
conjugating the one or more anti-tumor antibodies with nanoparticles to form functionalized antibody-coated nanoparticles,
administering, to the patient, the functionalized antibody-coated nanoparticles having a detectable property, the nanoparticles being further coated with a thermosensitive polymer coating,
heating the nanoparticles with an energy source to generate photoacoustic signals,
performing photoacoustic imaging with a photoacoustic imager to visualize any locally accumulated nanoparticles at a body site in the patient,
imaging the lesion at the site so as to determine the location of the lesion in or on the body of the patient by means of the locally accumulated nanoparticles, the lesion being otherwise radiographically undetectable absent the locally accumulated nanoparticles,
where the heating of the nanoparticles with the energy source further comprises heating the nanoparticles from a body temperature of 37° C. to a temperature between 40° C. and 43° C. to melt the thermosensitive polymer coating and release at least one of a medication, a gene together with a CRISPR/cas9 complex, or a checkpoint inhibitor from the nanoparticles,
treating the patient for the lesion by the release of the at least one medication, gene together with the CRISPR/cas9 complex, or checkpoint inhibitor from the nanoparticles locally at the location of the lesion, and
performing the method at least one time post-treatment to evaluate the treatment outcome quantifying the presence or absence of circulating cells or exosomes in the patient.

US Pat. No. 10,136,816

MEDICAL DEVICES AND METHODS

Abbott Diabetes Care Inc....

1. A system, comprising:an analyte sensor configured to be in fluid contact with bodily fluid under a skin surface;
sensor electronics including a memory, the sensor electronics operatively coupled to the analyte sensor to receive signals generated by the analyte sensor and to log data in the memory corresponding to the received signals generated by the analyte sensor, and further configured to detect a transmitted query; and
a display device configured for data communication with the sensor electronics, the display device comprising:
a storage device having stored therein one or more routines;
a processing unit operatively coupled to the storage device and configured to retrieve the stored one or more routines for execution;
a data transmission component operatively coupled to the processing unit and configured to transmit data based at least in part on the one or more routines executed by the processing unit; and
a data reception component operatively coupled to the processing unit and configured to receive analyte related data from the sensor electronics and to store the received analyte related data in the storage device;
wherein the data transmission component is programmed to transmit a query to the sensor electronics;
wherein the data reception component receives the analyte related data from the sensor electronics in response to the transmitted query when the sensor electronics transitions from a low power state to a fully operational state in response to detection of the query from the data transmission component by the sensor electronics; and
wherein the sensor electronics is configured to overwrite the logged data in the memory prior to an expiration of a life of the analyte sensor with new data corresponding to signals obtained from the analyte sensor after the expiration of the analyte sensor life, the sensor electronics configured to communicate to the data reception component of the display device the analyte related data that includes the logged data in the memory including the new data corresponding to the signals obtained from the analyte sensor after the expiration of the analyte sensor life.

US Pat. No. 10,136,814

AUTOMATIC PATHWAY AND WAYPOINT GENERATION AND NAVIGATION METHOD

COVIDIEN LP, Mansfield, ...

1. A method of providing a pathway from a starting point to a target location within a patient, comprising:selecting a target location within a patient;
using a processor to execute instructions stored on a non-transitory computer-readable storage medium to cause the processor to determine a pathway from a starting point to the target location by beginning at the target location and following back to the starting point, wherein determining the pathway includes assigning at least one waypoint along the pathway;
positioning a locatable guide at the starting point; and
advancing the locatable guide from the starting point to the target location following the determined pathway,
wherein determining the pathway further includes:
calculating an airway diameter along a path, as a candidate for the pathway, from the target to the starting point;
detecting a decrease in the airway diameter along the path; and
aborting the path if the decrease in the airway diameter is detected.

US Pat. No. 10,136,813

SYSTEMS AND METHODS FOR PATIENT CARDIOVASCULAR AND RESPIRATORY MANAGEMENT

1. A method for displaying integrated graphics for diagnostics for a patient's physiology, the method comprising:displaying a cardiac graphic object representing cardiac performance based on at least one measurement from the patient's left ventricle performance, said cardiac graphic object including at least a first, second, and third physiological parameter;
displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters;
displaying a pulmonary graphic object representing pulmonary performance, wherein displaying the pulmonary graphic object comprises displaying pulmonary vascular blood flow, and wherein the displaying the pulmonary vascular blood flow comprises displaying at least one measurement based on the patient's pulmonary arterial blood pressure and at least one measurement based on the patient's pulmonary venous blood pressure, and at least one measurement based on the patient's pulmonary vascular resistance; and
displaying a systemic vascular graphic object representing systemic cardiovascular performance, wherein displaying the systemic vascular graphic object comprises displaying systemic vascular blood flow, wherein the displaying the systemic vascular blood flow comprises displaying at least one measurement based on the patient's systemic arterial blood pressure and at least one measurement based on the patient's systemic venous blood pressure, and at least one measurement based on the patient's systemic vascular resistance.

US Pat. No. 10,136,810

SYSTEMS AND METHODS FOR DIAGNOSIS AND THERAPY OF VISION STABILITY DYSFUNCTION

NEUROSCIENCE RESEARCH AUS...

1. A device for obtaining vestibulo-ocular reflex data from a patient having a head and at least one eye, the device including:a frame configured for mounting to the patient;
a target module mounted to the frame and being responsive to a drive signal to project a selectively movable target object onto a surface in front of the patient;
an eye tracking module mounted to the frame, the module being adapted for obtaining first data indicative of one or more characteristics of the at least one eye; and
a head tracking module mounted to the frame, the head tracking module being adapted for obtaining second data indicative of one or more characteristics of the motion of the head.

US Pat. No. 10,136,809

OPHTHALMIC APPARATUS

KABUSHIKI KAISHA TOPCON, ...

1. An ophthalmic apparatus comprising:a refractive power measurement unit configured to project light from a light source onto a subject's eye and detect returning light thereof to determine refractive power of an ocular optical system of the subject's eye; and
an eyeball information measurement unit configured to project light from the light source onto the subject's eye and detect returning light thereof to determine eyeball information representing structure of the subject's eye.

US Pat. No. 10,136,808

OPTICAL COHERENCE TOMOGRAPHY AS A RAPID, ACCURATE, NON-CONTACT METHOD OF VISUALIZING THE PALISADES OF VOGT

1. A method of imaging palisades of Vogt comprising:imaging the palisades of Vogt via a non-contact in-vivo or ex-vivo process to acquire an image, wherein the imaging the palisades of Vogt via a non-contact in-vivo process to acquire the image comprises acquiring high-resolution images rapidly at a predetermined distance from a patient by directing laser light at a corneal limbus of the patient and measuring a delay caused by reflection of the laser light from the corneal limbus, wherein recognition of tissue boundaries depends on contrast between backscattered and/or reflected signal strength;
transferring the image to an analyzing component;
identifying in the analyzing component structures represented in the image to determine a status of the image;
and
storing the image in a data storage component for future evaluation or comparison.

US Pat. No. 10,136,806

IMAGE DISPLAY METHOD, IMAGE DISPLAY APPARATUS, AND STORAGE MEDIUM

Canon Kabushiki Kaisha, ...

1. An image display method comprising:acquiring a first image of a fundus within a first area of an eye to be inspected;
acquiring interference signal sets corresponding to a plurality of frames, which are acquired with an intention to acquire the same cross section, for a plurality of different cross sections;
generating, based on the interference signal sets corresponding to the plurality of frames, a motion contrast image of the fundus within a second area included in the first area; and
superimposing, for display, information acquired from a portion of the motion contrast image of the fundus onto a corresponding position of the first image of the fundus.

US Pat. No. 10,136,805

APPARATUS, SYSTEM, AND METHOD FOR INTRAOCULAR LENS POWER CALCULATION USING A REGRESSION FORMULA INCORPORATING CORNEAL SPHERICAL ABERRATION

AMO Groningen B.V., Gron...

1. A system for predicting optical power for an intraocular lens, comprising:a first device configured to measure at least one biometric parameter of an eye;
a second device configured to obtain a corneal spherical aberration of the eye according to the at least one biometric parameter;
at least one computing processor configured to apply a modified regression to the at least one biometric parameter and the corneal spherical aberration to output a prediction of an optical power for an intraocular lens to obtain a desired postoperative condition, wherein the modified regression is of the form:
optical power=Regression+constant0*(corneal spherical aberration)
or
optical power=constant1*(biometric parameter)+constant0*(corneal spherical aberration);
wherein constant1 and constant0 comprise an empirically derived factor across other eyes, and wherein Regression comprises a classical regression.

US Pat. No. 10,136,803

RING ILLUMINATED SURGICAL CAMERA

InnovaQuartz LLC, Phoeni...

1. A ring illuminated surgical camera comprising:a ring lens that includes
an emission surface adjacent to a distal end,
a reflector,
an external surface,
a proximal void adjacent to a proximal end, and
an electric wire conduit port passing through the emissions surface and adapted to carry an electronic imaging sensor and imaging sensor electrical contacts; and
a plurality of light emitting diodes (LEDs) carried within the proximal void, adjacent to an internal surface of the ring lens, and adapted to radially emit light.

US Pat. No. 10,136,802

DEVICE FOR SUSTAINED RELEASE OF OPTICAL CLEARING AGENT, ENDOSCOPE HAVING THE SAME, AND INSTRUMENT FOR ENDOSCOPIC SURGERY HAVING THE SAME

OLYMPUS CORPORATION, Tok...

1. A method for achieving sustained release of optical clearing agent comprising:(a) inserting into a lumen a device for sustained release of optical clearing agent without inflating any of at least two pouch-shaped elastic components of the device, the device comprising:
a stick-shaped component inside which at least two supplying passages are formed for supplying gas or liquid and which has apertures of the respective supplying passages formed at positions in a vicinity of a top end of the stick-shaped component along a circumference of a lateral surface thereof,
the at least two pouch-shaped elastic components placed at positions in the vicinity of the top end of the stick-shaped component along the circumference of the lateral surface of the stick-shaped component to cover the respective apertures of the supplying passages respectively;
(b) moving the device for sustained release of optical clearing agent so that the top end of the stick-shaped component, where the pouch-shaped elastic components are provided, is positioned to a diseased region on a wall surface of the lumen;
(c) rotating the stick-shaped component via a rotary unit until a body-fluid absorbing component fixed on a surface of a first pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(d) infusing gas or liquid into the first pouch-shaped elastic component from the aperture of a first supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the first supplying passage, to inflate the first pouch-shaped elastic component;
(e) pressing the body-fluid absorbing component against the diseased region through deformation of the first pouch-shaped elastic component, to make the body-fluid absorbing component absorb body fluid on a surface of and from inside the diseased region;
(f) discharging the gas or fluid from inside the first pouch-shaped elastic component through the aperture of the first supplying passage, to deflate the first pouch-shaped elastic component and detach the body-fluid absorbing component from the diseased region;
(g) rotating the stick-shaped component via the rotary unit until an optical clearing agent holding component fixed on a surface of a second pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(h) infusing gas or liquid into the second pouch-shaped elastic component from the aperture of a second supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the second supplying passage, to inflate the second pouch-shaped elastic component; and
(i) pressing the optical clearing agent holding component against the diseased region through deformation of the second pouch-shaped elastic component, to establish sustained release of optical clearing agent held by the optical clearing agent holding component to the diseased region.

US Pat. No. 10,136,801

BENDING PORTION AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending portion in which a plurality of bending pieces are pivotably continuously provided, the bending portion comprising:a first bending piece and a second bending piece provided adjacent to each other;
the first bending piece comprising:
a circular convex portion comprising a peripheral portion having a circular arc shape;
a support portion extended along an axial line direction of the first bending piece from a circular convex portion and supporting the circular convex portion;
a pair of engaging concave portions provided so as to sandwich the circular convex portion and the support portion; and
a pair of distal-end-side contact portions respectively extended from the engaging concave portions in an opposite direction of the circular convex portion,
the pair of engaging concave portions each comprising:
a first inclined portion extended from the support portion in a direction to form an obtuse angle with the support portion;
a second inclined portion extended from the first inclined portion in a direction to form an obtuse angle with the first inclined portion; and
an inside portion that is bent in an obtuse angle with respect to the second inclined portion and extended along a concentric arc of the peripheral portion so as to be adjacent to the distal-end-side contact portion; and
the second bending piece comprising:
a circular concave portion comprising an inside portion having a circular arc shape configured to slide with respect to the peripheral portion, the circular concave portion being provided so as to be pivotable around the circular convex portion;
a pair of engaging convex portions provided so as to sandwich the circular concave portion; and
a pair of proximal-end-side contact portions respectively extended from the engaging convex portions in an opposite direction from the circular concave portion, the pair of proximal-end-side contact portions being configured to come into contact with the distal-end-side contact portions when the circular concave portion pivots around the circular convex portion,
the pair of engaging convex portions each comprising:
 a pair of pointed portions having a shape along the support portion, the first inclined portion, and the second inclined portion, one of the pair of pointed portions being placed at a back of the engaging concave portion to face the support portion, the first inclined portion, and the second inclined portion when the distal-end-side contact portions and the proximal-end-side contact portion contact with each other; and
 an outside portion that is bent in an obtuse angle with respect to the pointed portions and extended along a concentric arc of the inside portion so as to be adjacent to the proximal-end-side contact portion.

US Pat. No. 10,136,800

BENDING OPERATION DEVICE AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending operation device, comprising:a bending lever that is inclinably supported with respect to an operation section of an endoscope;
an arm part that is provided on the bending lever and includes a distal end displaceable in conjunction with inclination operation of the bending lever; and
an intermediate lever, wherein
the intermediate lever includes a fixed end and a free end that are set on both ends in a longitudinal direction of the intermediate lever, the fixed end being swingably supported with respect to the operation section via a fulcrum, the intermediate lever further includes a force point between the fixed end and the free end and a point of application at a position on the intermediate lever that is farther from the fulcrum than the force point and is closer to the free end than the force point, the force point being connected to the distal end of the arm part through an intermediate wire, the point of application being connected to a bending wire, and the bending wire bending a bending portion provided in an insertion section of the endoscope.

US Pat. No. 10,136,798

ENDOSCOPIC SYSTEM

OLYMPUS CORPORATION, Tok...

1. An endoscopic system comprising:an endoscope comprising:
an insertion portion configured to be inserted into a body, the insertion portion having a channel to insert a treatment instrument through the channel, and
an operation portion connected to the insertion portion, the operation portion including a grasping portion configured to be grasped by a surgeon and an operation lever rotatably provided in the operation portion, the operation lever including a catching portion that catches the treatment instrument, the operation lever being configured to move the treatment instrument while being held by the catching portion to transmit a force of operation by the surgeon to the treatment instrument; and
an assistant instrument which assists the movement of the treatment instrument, the assistant instrument comprising:
a flexible tube in which an insertion path is formed to insert the treatment instrument,
a coupling portion which connects one end of the flexible tube and the channel so that the channel communicates with the insertion path, and
a holding portion including a base body connected to an other end of the flexible tube, the holding portion further including an attachment instrument attached to the operation portion so that the base body is disposed on a side of the operation portion where the operation lever is disposed.

US Pat. No. 10,136,797

ENDOSCOPE WITH EXTERNAL DEVICE CONNECTOR

FUJIFILM Corporation, To...

1. An endoscope apparatus, comprisingan insertion part that is inserted into a body cavity of a subject;
an operating part that is connected to the insertion part;
a universal cord that extends from the operating part; and
a connector part that is provided at a terminal of the universal cord away from the insertion part and is connected to an external device and transmits and receives a light signal to and from the external device,
wherein the connector part comprises:
a hollow metal member having two openings that communicate with each other;
an optical semiconductor element that is fixed to one opening side of the hollow metal member so as to be capable of sealing the periphery of the one opening;
a lens that is provided on the other opening side of the hollow metal member; and
a first sealing member that fixes the lens to the hollow metal member and seals a gap between the lens and the hollow metal member.

US Pat. No. 10,136,796

MEDICAL DEVICE POSITIONING SYSTEM

Boston Scientific Scimed,...

1. A medical device, comprising:an insertion portion, including:
a proximal portion including a first engagement member, the first engagement member including one of:
(a) a helical groove that leads into a linear groove, and
(b) a pin,
wherein the proximal portion further includes a deflectable endoscope shaft,
a distal portion rotatably coupled to the proximal portion, the distal portion including:
a laterally-facing opening, and
a second engagement member, the second engagement member including the other of the helical groove and the pin, the pin being slidably received by the helical groove and by the linear groove, wherein:
the helical groove extends at least 360 degrees about at least one of the proximal portion and the distal portion,
a longitudinal axis of the linear groove extends parallel to a longitudinal axis of the insertion portion,
engagement between the helical groove and the pin allows rotation of the distal portion relative to the proximal portion through an angle up to at least 360 degrees, and
rotation of the distal portion is caused by sliding of the pin along and against the helical groove as the distal portion is forced in one of a proximal direction and a distal direction.

US Pat. No. 10,136,795

DISH RACK RETAINING CLIP

Whirlpool Corporation, B...

1. A dish rack assembly, comprising:a dish rack having spaced wire frame elements at least partially defining a dish rack side wall and configured to retain dishes;
a height adjuster comprising an arm located on an exterior of the dish rack side wall having a pair of spaced first ribs extending therefrom with each of the pair of spaced first ribs extending along a different wire frame element, the height adjust further including a lever and wherein the arm is configured to be operably coupled to a tub side wall and the lever is configured to move the arm vertically to adjust the height of the dish rack with respect to the tub side wall; and
a retaining clip located on an interior of the dish rack side wall and having a planar body with a pair of second ribs extending therefrom, each of the pair of second ribs is complementary to each of the pair of first ribs;
wherein the retaining clip is mounted to the arm such that a first of the pair of first ribs and a first of the pair of second ribs are directly adjacent opposite lateral sides of a first of the spaced wire frame elements and the arm and retaining clip are on opposite sides, transverse to the lateral sides, of the first of the spaced wire frame elements and a second of the pair of first ribs and a second of the pair of second ribs are directly adjacent opposite lateral sides of a second of the spaced wire frame elements and the arm and retaining clip are on opposite sides, transverse to the lateral sides, of the second of the spaced wire frame elements.

US Pat. No. 10,136,794

MOVABLE CUTLERY BASKET

BSH Home Appliances Corpo...

1. A dishwasher rack, comprising:a frame including at least two contiguous sides disposed along a perimeter of the rack, the two sides including a first side and a second side;
a support rail disposed along the at least two sides of the frame such that the rail includes a first portion corresponding to the first side of the frame and a second portion corresponding to the second side of the frame; and
at least one cutlery basket coupled to the rail and arranged to be movable along the perimeter of the rack from the first portion of the rail to the second portion of the rail without disengaging from the rail as the at least one cutlery basket moves from the first portion of the rail to the second portion of the rail or vise versa.

US Pat. No. 10,136,793

DISHWASHER

Whirlpool Corporation, B...

1. A dishwasher comprising:a tub having an open face and at least partially defining a treating chamber receiving dishes for treatment and having a tub air outlet located in an upper portion of the tub and a tub air inlet located in a lower portion of the tub;
a door assembly moveable between an opened position and a closed position where the door assembly closes the open face;
an airflow conduit extending along a portion of the tub and fluidly coupling the tub air outlet to ambient air;
a blower assembly forcing air to flow from the tub and through the tub air outlet into the airflow conduit;
a first reservoir associated with the airflow conduit and located vertically between the tub air outlet and tub air inlet, the first reservoir collecting liquid condensed from the air forced through the airflow conduit, the first reservoir having a liquid outlet at a nadir of the first reservoir and wherein the liquid outlet is fluidly coupled to an opening the tub via a liquid conduit for draining the collected liquid into the tub and wherein the opening in the tub comprises a water inlet for the tub, wherein the water inlet receives water from a household water supply; and
a second reservoir associated with the airflow conduit downstream of the first reservoir and collecting liquid condensed from the air prior to exhaustion of the air to the ambient air;
wherein any liquid not collected by the first reservoir is collected by the second reservoir for evaporation.

US Pat. No. 10,136,792

HOUSEHOLD APPLIANCE

1. A household appliance assembly, comprising:a household appliance having a treatment container which defines a treatment chamber;
at least one packing element including a positioning aid and disposed on a side face of the household appliance, wherein the packing element is adapted to prevent damage to the household appliance due to forces occurring during at least one of storage and transportation of the household appliance, and the positioning aid includes one of a projection and a recess; and
the household appliance further comprising at least one load-bearing structural part with a cross-sectional profile that includes the other of the projection and the recess, the at least one load-bearing structural part being positioned externally of the treatment chamber, such that the other of the projection and the recess of the at least one load-bearing structural part is exposed so as to be accessible from outside of the household appliance,
wherein the packing element has at least one force transfer region, which has a force action surface in direct contact with the load-bearing structural part,
the household appliance is configured to be a built-in appliance that does not have external casing walls at least where the packing element is disposed, and
the cross-sectional profile is inserted into the positioning aid or the positioning aid is inserted into the cross-sectional profile such that the projection and the recess are in contour-matched contact.

US Pat. No. 10,136,790

APPLICATOR FOR SANITIZING AND/OR DISINFECTING SOLUTION

TIETEX INTERNATIONAL, LTD...

1. A textile applicator of fibrous construction for application of a liquid sanitizing or disinfecting solution to a surface, the applicator comprising:a plurality of multi-filament microfiber stitching yarns disposed in stitched relation through at least one layer of polyester or polypropylene fleece in a stitch-bonded fabric construction forming a liquid carrier fabric for collection and dispersal of the sanitizing or disinfecting solution, wherein the microfiber yarns comprise a plurality of direct spun polyester filaments characterized by a substantially circular cross sectional perimeter and a linear density of less than 1 denier per filament, the liquid carrier fabric being nonreactive with both quaternary ammonium compounds, and chlorine such that the concentration of quaternary ammonium compounds or chlorine in the sanitizing or disinfecting solution degrades by not more than about 10% following immersion of the liquid carrier fabric in the sanitizing or disinfecting solution for a period of one hour.

US Pat. No. 10,136,788

BROOM

1. A broom comprising a head and a handle, wherein the head comprises:a first portion having a plurality of bristles on a first side surface thereof;
a second portion extending outwardly from a first longitudinal side of the first portion at an angle thereto;
a recess in a distal edge of the second portion extending from adjacent a first end of the second portion to adjacent a second end of the second portion;
a scraper blade comprising an elongate member fixed at least partially within the recess such that at least portions of longitudinal ends of the scraper blade are enclosed by sections of the second portion located between the ends of the recess and longitudinal ends of the second portion;
wherein the outer edge of the scraper blade extends beyond the second portion of the head in order to contact the ground for scraping.

US Pat. No. 10,136,787

IMAGE PROCESSING METHOD AND IMAGE PROCESSING APPARATUS WHICH CAN PERFORM BACKGROUND NOISE REMOVING BASED ON COMBINED IMAGE

PixArt Imaging Inc., Hsi...

1. An image processing method, applied to an image processing apparatus comprising a light source and an image sensor, wherein the image sensing method comprises:acquiring a first image via the image sensor when the light source does not emit light;
acquiring a second image via the image sensor when the light source emits light;
acquiring a third image via the image sensor when the light source operates does not emit light;
generating a combined image based on only part of contents of the first image and only part of contents of the third image, but not based on the second image; and
acquiring a target image after background noise removing via subtracting the combined image from second image.

US Pat. No. 10,136,782

MULTI-FUNCTION COMBINED BRUSH FOR VACUUM CLEANER

Spival S.P.A., Larciano ...

1. A combined brush for vacuum cleaner comprising at least one suction duct, one fixed part, and two or several frames, each movable with respect to said fixed part from a retracted position to an extracted position, wherein each of said two or several movable frames is extracted or retracted according to an alternating translatory movement controlled by the intermittent rotation of a shaft, wherein the extraction of each movable frame takes place at at least one angular position of said shaft, said at least one angular position being different from the angular positions at which the other or the other movable frames are extracted.
US Pat. No. 10,137,202

ANTIBODY-DRUG CONJUGATES AND IMMUNOTOXINS

Oncomatryx Biopharma, S.L...

1. A conjugate having the formula I:A-(L-D)p  (I)
or a pharmaceutically acceptable salt or solvate thereof,
wherein:
A is an antibody that selectively binds fibroblast activation protein alpha (FAP), said antibody comprising heavy chain complementarity determining regions 1-3 (CDRH1-3) and light chain complementarity determining regions 1-3 (CDRL1-3) having the following amino acid sequences:
(i) CDRH1: SEQ ID NO: 7;
(ii) CDRH2: SEQ ID NO: 8;
(iii) CDRH3: SEQ ID NO: 9;
(iv) CDRL1: SEQ ID NO: 10;
(v) CDRL2: SEQ ID NO: 11; and
(vi) CDRL3: SEQ ID NO: 12;
L is a linker;
D is a drug comprising a cytolysin; and
p is 1 to 10.
US Pat. No. 10,137,203

HER2 APTAMER-ANTICANCER DRUG COMPLEX FOR CANCER CELL CHEMOTHERAPY

Korea University Research...

1. A method of manufacturing a complex for cancer cell chemotherapy, comprising:a) preparing a nucleic acid aptamer consisting of the base sequence of SEQ ID NO:1 for specifically binding to HER2; and
b) forming an aptamer-anticancer drug complex by reacting the aptamer with anticancer drug DM1;
wherein the aptamer includes a thiol group introduced at the 3? terminal end and DM1 includes a thiol group such that a disulfide bond is formed between the aptamer and DM1.
US Pat. No. 10,137,205

THYMIDYLATE KINASE FUSIONS AND USES THEREOF

University Health Network...

1. A composition comprising:(a) a stably integrating delivery vector;
(b) a polynucleotide encoding a modified human thymidylate kinase (tmpk), wherein the modified human tmpk increases phosphorylation of 3?-azido-3?-deoxythymidine (AZT) relative to phosphorylation of AZT by wild-type human tmpk; and
(c) a polynucleotide encoding a detection cassette polypeptide that is expressed on the surface of a cell, wherein the polynucleotide encoding the detection cassette polypeptide is fused to the polynucleotide encoding the modified human tmpk and the detection cassette polypeptide is fused to the modified human tmpk;
wherein the modified human tmpk comprises a modification selected from the group consisting of (i) a F to Y mutation at amino acid position 105 of SEQ ID NO: 11; (ii) a R to G mutation at amino acid position 16 of SEQ ID NO: 12; and (iii) a R to A mutation at amino acid position 200 of SEQ ID NO: 16.
US Pat. No. 10,138,486

INHIBITORS OF DEK PROTEIN AND RELATED METHODS

THE REGENTS OF THE UNIVER...

1. A method of treating or ameliorating an inflammatory condition in a patient, comprising administering to said patient a therapeutically effective amount of a single-stranded anti-DEK DNA aptamer, and a pharmaceutically acceptable carrier, wherein said anti-DEK DNA aptamer is SEQ ID NO:1, SEQ ID NO: 2 or SEQ ID NO:6.
US Pat. No. 10,137,208

VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE-ENHANCED RAMAN NANOPARTICLE TAGS

Emory University, Atlant...

1. A surface-enhanced Raman spectroscopic active composite nanostructure comprising:a single-core metallic nanoparticle with a diameter of 100 nm or less;
a Raman reporter molecule disposed on the surface of the core; and
an encapsulating protective layer disposed on the surface of the core and the reporter molecule, wherein the encapsulating protective layer is a thiolpolyethylene glycol, and wherein the encapsulated reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.
US Pat. No. 10,138,489

CYANOBACTERIAL STRAINS CAPABLE OF UTILIZING PHOSPHITE

Algenol Biotech LLC, For...

1. A genetically modified cyanobacterial cell for the production of a product of interest, comprising:a) at least one recombinant gene that encodes a heterologous phosphite dehydrogenase enzyme EC:1.20.1.1 that catalyzes the oxidation of phosphite to phosphate, wherein said enzyme has at least 85% identity to the protein sequence of the Ralstonia phosphite dehydrogenase enzyme (SEQ ID NO: 12);
b) an operon comprising at least one recombinant phosphite transporter gene encoding at least one phosphite transporter protein for transporting phosphite into the cell wherein the at least one phosphite transporter protein has at least 85% identity to a protein sequence selected from the group consisting of Cyanothece PtxA (SEQ ID NO: 19), Cyanothece PtxB (SEQ ID NO:22), Cyanothece PtxC (SEQ ID NO: 25), and Desulfotignum phosphitoxidans PtdC (SEQ ID NO: 28);
c) a knockout or knockdown of a gene encoding an endogenous protein having at least 85% identity to the repressor protein PhoU; and
d) at least one recombinant production gene encoding a polypeptide for the production of said product of interest.
US Pat. No. 10,138,490

TRANSFORMED PLANTS TOLERANT TO HERBICIDES DUE TO OVEREXPRESSION OF PREPHENATE DEHYDROGENASE AND P-HYDROXYPHENYLPYRUVATE DIOXYGENASE

1. A method for cultivating a transformed plant, the method comprisinga) planting a seed of the transformed plant,
b) contacting the seed or a transformed plant grown from the seed with a herbicidal composition comprising an inhibitor of p-hydroxyphenylpyruvate dioxygenase, and
c) cultivating the plant, wherein the transformed seed or the transformed plant is substantially unaffected by the herbicidal composition, wherein the plant comprises:
(1) a first gene that is functional in a plant, wherein the first gene comprises a nucleotide sequence that encodes a yeast prephenate dehydrogenase, and
(2) a second gene that is functional in a plant, wherein the second gene comprises a nucleotide sequence that encodes a p-hydroxyphenylpyruvate dioxygenase, and
wherein the plant overexpresses the prephenate dehydrogenase and the p-hydroxyphenylpyruvate dioxygenase, and wherein said plant is tolerant to an amount of said inhibitor that is toxic to or decreases the growth of plants transformed with said second gene alone.
US Pat. No. 10,138,234

2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-A]PYRIDINE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound selected from the group consisting of:N-(2-fluoroethyl)-2-phenylimidazo[1,2-a]pyridin-7-amine,
N-(2-fluoroethyl)-N-methyl-2-phenylimidazo[1,2-a]pyridin-7-amine,
N,N-dimethyl-2-phenylimidazo[1,2-a]pyridin-7-amine,
N-methyl-2-phenylimidazo[1,2-a]pyridin-7-amine,
[2-(4-dimethylamino-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
(2-[4-(2-fluoro-ethoxy)-phenyl]-imidazo[1,2-a]pyridin-7-yl}-dimethyl-amine,
[2-(4-fluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
N-methyl-2-m-tolylimidazo[1,2-a]pyridin-7-amine,
N,N-dimethyl-(2-m-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
N,N-dimethyl-(2-p-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
N-methyl-(2-p-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
N-(2-fluoroethyl)-N-methyl-(2-p-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
2-(4-(dimethylamino)phenyl)-N-(2-fluoroethyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
[2-(3-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
(2-fluoro-ethyl)-methyl-(2-m-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine
[2-(3-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
[2-(4-fluoromethoxy-phenyl)-imidazo[1,2-a]pyri din-7-yl]-methyl-amine,
(2-fluoro-ethyl)-(2-p-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
(2-fluoro-ethyl)-(2-m-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
(2-fluoro-ethyl)-[2-(4-fluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
[2-(3,4-dimethyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
[2-(3,4-dimethyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
[3H]-[2-(4-fluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
[3H]—N-methyl-2-phenyl-imidazo[1,2-a]pyridin-7-amine,
[3H]—N-(2-fluoroethyl)-2-phenyl-imidazo[1,2-a]pyridin-7-amine,
[3H]—N-methyl-(2-p-tolyl-imidazo[1,2-a]pyridin-7-yl)-amine,
(2-fluoro-ethyl)-[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
[2-(3,4-dimethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
cyclopropyl-[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
methyl-[2-(4-methyl sulfanyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
[2-(3,4-dimethyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-(2-fluoro-ethyl)-amine,
[2-(3,4-dimethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-(2-fluoro-ethyl)-amine,
[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
(2-fluoro-ethyl)-[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
(2-fluoro-ethyl)-[2-(3-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
[2-(3-fluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-dimethyl-amine,
(2-fluoro-ethyl)-[2-(4-methyl sulfanyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
cyclopropyl-[2-(4-fluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
2-methoxy-4-(7-methylamino-imidazo[1,2-a]pyridin-2-yl)-phenol,
3-(7-dimethylamino-imidazo[1,2-a]pyridin-2-yl)-phenol,
[4-[7-(methylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]methanol,
[4-[7-(dimethylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]methanol,
2-(3,5-dimethoxyphenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
N-[2-(4-ethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
methyl-[2-(4-pyrrolidin-1-yl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
N-[2-(3-fluoro-4-methoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
N-[2-(4-diethylamino-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
N-[2-(4-ethyl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
2-[4-(methoxymethyl)phenyl]-N,N-dimethyl-imidazo[1,2-a]pyridin-7-amine,
methyl-[2-(4-morpholin-4-yl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
2-[4-(2-fluoroethoxymethyl)phenyl]-N,N-dimethyl-imidazo[1,2-a]pyridin-7-amine,
2-(3-methoxy-4-methylphenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
2-[4-(2-fluoroethoxy)phenyl]-N-methylimidazo[1,2-a]pyridin-7-amine,
2-(4-(benzyl(methyl)amino)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
N-[2-(4-difluoromethoxy-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
N-[2-(4-bromo-phenyl)-imidazo[1,2-a]pyridin-7-yl]-methyl-amine,
methyl-[2-(4-piperidin-1-yl-phenyl)-imidazo[1,2-a]pyridin-7-yl]-amine,
2-(7-methylamino-imidazo[1,2-a]pyridin-2-yl)-phenol,
methyl 3-[7-(methylamino)imidazo[1,2-a]pyridin-2-yl]benzoate,
[3-[7-(methylamino)imidazo[1,2-a]pyridin-2-yl]phenyl]methanol,
N-cyclopropyl-2-[4-(2-fluoroethoxy)phenyl]imidazo[1,2-a]pyridin-7-amine,
7-(azetidin-1-yl)-2-[4-(3-fluoropropoxy)phenyl]imidazo[1,2-a]pyridine,
4-methyl-2-(7-methylamino-imidazo[1,2-a]pyridin-2-yl)-phenol,
2-[3-(methoxymethyl)phenyl]-N-methyl-imidazo[1,2-a]pyridine-7-amine,
2-(4-(2-fluoroethylamino)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
N-(3-fluoropropyl)-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-7-amine,
2-(3-(fluoromethoxy)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
2-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-7-ylamino)propan-1-ol,
N-(2-fluoroethyl)-2-(3-methoxy-4-methylphenyl)imidazo[1,2-a]pyridin-7-amine,
N-methyl-2-(3-(methylthio)phenyl)imidazo[1,2-a]pyridin-7-amine,
2-(3-(2-fluoroethoxy)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
2-(3-(3-fluoropropoxy)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
2-(4-(4-fluoropiperidin-1-yl)phenyl)-N-methylimidazo[1,2-a]pyridin-7-amine,
4-(7-(2-fluoroethylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol,
4-(7-(2-fluoroethylamino)imidazo[1,2-a]pyridin-2-yl)phenol,
3-(7-(2-fluoroethylamino)imidazo[1,2-a]pyridin-2-yl)phenol,
N-(2-fluoroethyl)-2-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyridin-7-amine, and
N-cyclopropyl-2-[4-(3-fluoropropoxy)phenyl]imidazo[1,2-a]pyridin-7-amine, or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,139,003

LIP SEAL FOR WATER PUMP

Eagle Industry Co., Ltd.,...

1. A lip seal for water pump made of a rubber-like elastic material, fixed to a housing as a fixed side and in sliding contact with a shaft rotating relative to the housing;the lip seal having sliding surface with a surface roughness Ra (according to JIS B0601 corresponding to ISO 4287) of 1 to 30 ?m, being obtained by vulcanization-molding of a rubber composition comprising 100 parts by weight of hydrogenated nitrile rubber or EPDM, 1 to 150 parts by weight of a reinforcing filler, 5 to 90 parts by weight of a non-reinforcing filler having an average particle diameter of 1 ?m or more, 0.1 to 5 parts by weight of a coupling agent, 1 to 15 parts by weight of a co-crosslinking agent, and 0.5 to 10 parts by weight of an organic peroxide.
US Pat. No. 10,138,492

NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES CONFERRING IMPROVED NITROGEN USE EFFICIENCY CHARACTERISTICS IN PLANTS

Ceres, Inc., Thousand Oa...

1. A method of producing a plant, said method comprising(a) growing a plant cell comprising an exogenous nucleic acid, said exogenous nucleic acid comprising a regulatory region operably linked to a nucleotide sequence, said nucleotide sequence comprising 95 percent or greater sequence identity to the nucleotide sequence of SEQ ID NO:48, or wherein said nucleotide sequence encodes a polypeptide comprising 95 percent or greater sequence identity to the amino acid sequence of SEQ ID NO:49;
(b) growing a plant from said plant cell; and
(c) selecting for a plant comprising an increased level of low-nitrogen tolerance as compared to the corresponding level of low-nitrogen tolerance of a control plant that does not comprise said nucleic acid.
US Pat. No. 10,138,493

SYNTHETIC TRANSCRIPTIONAL AND EPIGENETIC REGULATORS BASED ON ENGINEERED, ORTHOGONAL ZINC FINGER PROTEINS

TRUSTEES OF BOSTON UNIVER...

1. An engineered responsive promoter comprising (a) at least one target DNA sequence element selected from the group consisting of 5?-CGTCGAAGTCGAAGTCGACC-3? (SEQ ID NO: 81), 5?-GGACGACGTTACGGACGTAC-3? (SEQ ID NO: 82), 5?-A GACGTCGAAGTAGCCGTAG-3? (SEQ ID NO: 83), 5?-GGACGACGCCGATGTAGAAG-3? (SEQ ID NO: 84), 5?-TGAAGCAGTCGACGCCGAAG-3? (SEQ ID NO: 85), 5?-GGACGACGCGGTCTAAGAAG-3? (SEQ ID NO: 86), 5?-CGACGAGGTCGCATAAGTAG-3? (SEQ ID NO: 87), 5?-AGACGCAGTATAGGTCGAAC-3? (SEQ ID NO: 88), 5?-AGACGCAGTATAGGACGACG-3? (SEQ ID NO: 89), 5?-CGGCGTAGCCGATGTCGCGC-3? (SEQ ID NO: 90), and 5?-GGTCGTTGCGGTAGTCGAAG-3? (SEQ ID NO: 91) and (b) a promoter sequence, wherein the at least one target DNA sequence element is operably linked at the 5? end of the promoter sequence in order to influence transcription initiation of a nearby coding sequence.
US Pat. No. 10,137,215

ORGANIC WASTE ODOR ABSORBER

1. A method of treating organic waste comprising:a step of placing a composition within a receptacle to create a layer on the bottom of said receptacle;
a step of placing organic waste within said receptacle already containing the layer of said composition, where said organic waste is placed on top of said composition;
a step of placing additional said composition on top of said organic waste within said receptacle;wherein said composition's materials comprise:a. 35% to 85% holocellulose, by weight
b. 8% to 30% lignin, by weight
c. 40% to 80% silica, by weight;wherein said composition comprises dried materials;wherein said composition's materials comprise a particle size range from 0.002 millimeters in diameter to 300 by 300 by 300 millimeters;wherein said composition comprises a scent;wherein said organic waste is composted.
US Pat. No. 10,137,475

COATING SYSTEM, A METHOD OF APPLYING THE COATING SYSTEM AND AN ARTICLE COMPRISING THE COATING SYSTEM

Dow Global Technologies L...

1. A method of applying a multi-layer coating system comprising:(I) selecting an epoxy formulation which comprises
(a1) epoxy resin;
(a2) curing agent selected from the group consisting of amine adducts, amides, polyamides, and Mannich bases derived from polyfunctional amines with no more than 4.5 wt % free amine based on a weight solids of the curing agent; and
(II) applying the epoxy formulation onto a substrate;
(III) fully or partially curing the epoxy formulation to produce an epoxy coating layer;
(IV) selecting a non-isocyanate polyurethane formulation;
(V) applying the non-isocyanate polyurethane formulation onto the epoxy coating layer; and
(VI) allowing the topcoat formulation and epoxy formulation to fully cure thereby forming a multi-layer coating system;
wherein the epoxy formulation and/or non-isocyanate polyurethane formulation optionally further comprise one or more additives selected from the group consisting of solvent, reactive diluent, plasticizer, pigment, filler; rheology modifiers, dispersants, surfactants, UV stabilizers, and corrosion inhibitors.
US Pat. No. 10,138,500

D-LACTIC ACID-PRODUCING STRAIN AND USE THEREOF

CJ CHEIJEDANG CORPORATION...

1. A D-lactic acid-producing strain modified to attenuate or inactivate L-lactate dehydrogenase (L-LDH) activity and to enhance D-lactate dehydrogenase (D-LDH) activity, wherein the D-lactic acid-producing strain so modified is a Lactobacillus sp strain which produces more L-lactic acid than D-lactic acid prior to said modification; wherein the L-LDH activity is derived from a L-LDH-encoding polynucleotide from Lactobacillus paracasei, Lactobacillus casei, or Lactobacillus rhamnosus; wherein the D-LDH activity is derived from a D-LDH-encoding polynucleotide from Lactobacillus plantarum or Lactobacillus delbrueckii; and wherein the Lactobacillus sp. strain is selected from the group consisting of Lactobacillus casei, Lactobacillus paracasei, and Lactobacillus rhamnosus.
US Pat. No. 10,136,708

LIGHT PRECIOUS ALLOY OF GOLD AND TITANIUM AND COMPONENTS FOR TIMEPIECES OR JEWELLERY MADE FROM SUCH A LIGHT PRECIOUS ALLOY OF GOLD AND TITANIUM

1. A light, precious gold-titanium based alloy comprising, by mass, from 750‰ to 780‰ of gold,wherein said alloy has the following composition formula:
TiaAubMcTd
where a b, c, d are atomic proportions such that:
a+b+c+d=1,
0.45?a?0.55; 0.41?b?0.495; 0.025?c?0.13; 0.001?d?0.025,
wherein M represents at least one element selected from the group consisting of Nb, V, Pd, Pt, and Fe, and
T represents boron and optionally an additional element, and
wherein the additional element is selected from the group consisting of Nb, V, Pd, Pt, Fe, Mo, Ta, W, Co, Ni, Ru, Rh, Ir, Cr, Mn, Cu, Zn, Ag, Al, Si, Ge, Sn, Sb, and In,
M and T are different elements, and
the alloy comprises the boron as T or as a part of T in an atomic content of from 0.03% to 0.3%.
US Pat. No. 10,137,476

COATING AGENT FOR CORROSION-RESISTANT COATINGS

1. A multicoat color and/or effect paint system comprising, lying above one another in this order,(1) at least one first basecoat comprising a basecoat material (A);
(2) a second color and/or effect basecoat comprising a basecoat material (B); and
(3) at least one transparent coating comprising a clearcoat material (C);
wherein the basecoat material (A) comprises:
(a.1) at least one binder,
(a.2) at least one color or effect pigment, and
(a.3) at least one water-soluble or water-dispersible, corrosion-inhibiting, oligomeric or polymeric component comprising:
a parent structure (GK) comprising at least two repeating monomer units (ME) and
at least one uni- and/or multidentate, potentially anionic ligand (L) capable of forming complexes after the multicoat paint system has been thermally cured,
wherein the monomer units (ME) are ethylenimines units and the ligand (L) is hydroxyacetophenone.
US Pat. No. 10,138,501

METHOD FOR PREPARING DIGLYCERIDE USING BUBBLE COLUMN REACTOR

Jinan University, Guangz...

1. A method for synthesizing diglyceride using a bubble column reactor, characterized by comprising the steps of:(1) placing an immobilized enzyme on the bearing mechanism of the bubble column reactor, and a hot bath mechanism is actuated to heat the reactor body to 55-75° C.;
(2) adding glycerol and fatty acid in a feed chute as reactants, and water is added as an activating enzyme catalyst; wherein the molar ratio of glycerol and fatty acid is 1:1-10:1; the added amount of water is less than 10% of the total mass of the reactants; and the added amount of the immobilized enzyme in step (1) is 1-10% of the total mass of the reactants;
(3) preheating glycerin, fatty acids and water in the feed chute to 55-75° C., then charged into the reactor body to initiate a synthesis reaction; a blowing mechanism is actuated and the flow rate of an inert gas is controlled at 0.7-5.7 cm/s, so that the inert gas is continuously blown into the reactor body via a sieve plate, forming boiling bubbles;
(4) turning off the hot bath mechanism and the blowing mechanism after the synthesis reaction is carried out for 15-90 min, stopping the heating and the inert gas circulation, actuating a compacting mechanism, and standing and layering the reaction mixture, thus obtaining an upper layer, which is a crude glycerin layer, and a lower layer, which is a glycerol layer; the crude glycerin layer is removed off the free fatty acids via a first-stage molecular distillation, then sent into a second-stage molecular distillation, thus obtaining a distillate and a distillation residue; wherein the distillate is high purity diglyceride, and the distillation residue is monoglyceride;
wherein the bubble column reactor in step (1) comprises a reactor body, a bearing mechanism, a sieve plate, a compacting mechanism, a blowing mechanism, a hot bath mechanism, a feed chute, and a connecting cylinder, wherein the reactor body, the bearing mechanism and the connecting cylinder are connected sequentially from top to bottom; the hot bath mechanism, the reactor body, and feed chute are sequentially connected, and formed a hot bath circulation; the reactor body is communicated with the connecting cylinder, the connecting cylinder is connected to the blowing mechanism, the sieve plate is placed on the upper end of the connecting cylinder, the compacting mechanism is mounted on the connecting cylinder, the upper end of the compacting mechanism is inserted into the connecting cylinder, and the upper end of the compacting mechanism is abutted against the sieve plate;
wherein the compacting mechanism comprises a floating joint, a cylinder, a compacting head, wherein the piston rod of the cylinder is connected to the compacting head via the floating joint, the compacting head is abutted against the sieve plate; the upper end of the compacting head is provided with a first upper cavity, the first upper cavity is communicated with the internal cavity of the reactor body via the sieve plate, the bottom surface of the first upper cavity is arranged in an inclined mode; the lower end of the compacting head is provided with a first lower cavity, the floating joint is connected to the first lower cavity; the side wall of the upper end of the compacting head is provided with a first through hole, the first through hole is communicated with the first upper cavity and the internal cavity of the connecting cylinder; and
wherein the internal cavity of the connecting cylinder is provided with flow-guiding plate, the internal cavity of the connecting cylinder is divided into a second upper cavity and the second upper cavity by the flow-guiding plate, the second upper cavity is communicated with the internal cavity of the reactor body, the flow-guiding plate is arranged in an inclined mode, the middle of the flow-guiding plate is provided with a second through hole through which the piston rod of the cylinder passes, the floating joint is sleeved with a sealing sleeve, the sealing sleeve is closely connected to the second through hole; the connecting cylinder is provided with a gas ventilating hole and a liquid collecting hole, both the gas ventilating hole and the liquid collecting hole are communicated with the second upper cavity, the gas ventilating hole is connected to the blowing mechanism; the axis of the liquid collecting hole is arranged in parallel with the flow-guiding plate, and the lower end of the flow-guiding plate is at the same height as that of the lower edge of the liquid collecting hole.
US Pat. No. 10,137,733

PNEUMATIC TIRE

SUMITOMO RUBBER INDUSTRIE...

1. A pneumatic tire, comprising a tread formed from a rubber composition,the rubber composition comprising:
an oil-extended polybutadiene rubber having a cis content of 95 mol % or more, a vinyl content of 1 mol % or less, and a weight average molecular weight of 530,000 or more;
at least one of an isoprene-based diene rubber or a styrene-butadiene rubber;
a carbon black having a nitrogen adsorption specific surface area of 110 to 200 m2/g; and
stearic acid,
the oil-extended polybutadiene rubber being synthesized using a rare earth catalyst,
the rubber composition comprising, based on 100% by mass of the total rubber solids, 8% to 65% by mass of a polybutadiene rubber component contained in the oil-extended polybutadiene rubber and 20% to 85% by mass of the at least one of an isoprene-based diene rubber or a styrene-butadiene rubber,
the rubber composition comprising, relative to 100 parts by mass of the total rubber solids, 20 to 100 parts by mass of the carbon black and 1.5 to 2.99 parts by mass of the stearic acid,
the rubber composition having an amount of process oil of 9 parts by mass or less relative to 100 parts by mass of the total rubber solids.
US Pat. No. 10,138,502

METHOD FOR PRODUCING OIL CONTAINING POLYUNSATURATED FATTY ACID USING LIPASE

NIPPON SUISAN KAISHA, LTD...

1. A method for lowering saturated fatty acid content in a glyceride containing a polyunsaturated fatty acid, the method comprising:concentrating the polyunsaturated fatty acid using a lipase having low reactivity for the polyunsaturated fatty acid to hydrolyze the glyceride containing the polyunsaturated fatty acid, wherein the glyceride containing the polyunsaturated fatty acid is a marine animal oil glyceride or a microorganism oil glyceride;
wherein the polyunsaturated fatty acid is a fatty acid having at least 20 carbon atoms and having at least 3 double bonds,
wherein the hydrolysis by the lipase is performed in the presence of 10 to 200 weight percent of water based on a total weight of the glyceride containing the polyunsaturated fatty acid, and at a temperature from 10° C. to 20° C.,
wherein the lipase is derived from a microorganism selected from the group consisting of Candida cylindracea and Alcaligenes sp.; and
wherein the saturated fatty acid content in the resulting glyceride is less than the saturated fatty acid content in the glyceride prior to the concentrating.
US Pat. No. 10,137,222

FIBRIN COMPOSITION, METHOD AND WOUND ARTICLES

3M INNOVATIVE PROPERTIES ...

1. A method of forming a fibrin hydrogel composition comprisingforming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt; wherein the fibrin hydrogel forming salt has a concentration greater than or equal to the threshold concentration to form a fibrin hydrogel;
reducing the salt concentration below the threshold concentration to form a fibrin hydrogel.
US Pat. No. 10,137,224

ALLOGENEIC MICROVASCULAR TISSUE FOR SOFT TISSUE TREATMENTS

MICROVASCULAR TISSUES, IN...

1. A processed microvascular tissue comprising:a dried microvascular tissue, wherein the microvascular tissue comprises dissociated, and uncultured stem or progenitor cells having intact cell membranes, wherein the viability of the uncultured stem or progenitor cells in the processed microvascular tissue is less than 30%, and wherein the processed microvascular tissue has tissue healing activity.
US Pat. No. 10,137,225

CRYSTALLINE COATING AND RELEASE OF BIOACTIVE AGENTS

Yissum Research Developme...

1. A process of depositing at least a first layer of a first therapeutically active agent onto at least a continuous portion of a surface of an object, wherein at least 50 weight percents of said first layer is said first therapeutically active agent in a crystalline form, the process comprising:seeding said surface of said object with crystals of said first therapeutically active agent, so as to obtain a seeded surface comprising said crystals; and
contacting said seeded surface with a solution containing said first therapeutically active agent for at least 5 minutes, so as to effect precipitation of said first therapeutically active agent onto said seeded surface in a crystalline form, thereby forming said crystalline form of said first therapeutically active agent deposited on at least said portion of said surface,
wherein said surface is not cooled to a temperature below a temperature of said solution.
US Pat. No. 10,138,506

ENZYMATIC PRODUCTION OF D-TAGATOSE

BONUMOSE LLC, Charlottes...

1. An enzymatic process for preparing tagatose from a starch derivative, the process comprising the steps of:(i) converting a saccharide to glucose 1-phosphate (G1P) using alpha glucan phosphorylase (?GP), wherein the saccharide is selected from one or more derivatives of starch;
(ii) converting G1P to glucose 6-phosphate (G6P) using a phosphoglucomutase (PGM);
(iii) converting G6P to fructose 6-phosphate (F6P) using a phosphoglucoisomerase (PGI);
(iv) converting fructose 6-phosphate (F6P) to tagatose 6-phosphate (T6P) catalyzed by a fructose 6-phosphate epimerase (F6PE); and
(v) converting the T6P produced to tagatose catalyzed by a tagatose 6-phosphate phosphatase (T6PP)
wherein steps (i)-(v) are conducted in a single reaction vessel.
US Pat. No. 10,138,509

METHOD FOR GENERATING A THREE-DIMENSIONAL NUCLEIC ACID CONTAINING MATRIX

President and Fellows of ...

1. A method of identifying nucleic acids within a cell, comprising:contacting a plurality of nucleic acids having a relative three-dimensional spatial relationship within the cell with a matrix-forming material in a manner to substantially retain the relative three-dimensional spatial relationship;
using the matrix-forming material to form a three-dimensional polymerized matrix including the nucleic acids of the plurality of nucleic acids covalently bound to the three-dimensional polymerized matrix; and
detecting signals from the nucleic acids or derivatives thereof, thereby identifying the nucleic acids.
US Pat. No. 10,138,510

DUAL LABELING METHODS FOR MEASURING CELLULAR PROLIFERATION

LIFE TECHNOLOGIES CORPORA...

1. A method for measuring a change in cellular DNA synthesis:a) incubating a sample with an effective amount of a first nucleoside or nucleotide analog comprising an ethynyl group to form a primary incubated sample,
wherein the first nucleoside or nucleotide analog is ethynyl-deoxyuracil (EdU);
b) incubating the primary incubated sample with a second nucleoside or nucleotide analog comprising a halogen moiety to form a secondary incubated sample,
wherein the second nucleoside or nucleotide analog is BrdU, and wherein the first nucleoside or nucleotide analog is not incorporated into a DNA polymer when the second nucleoside or nucleotide analog is present;
c) incubating the secondary incubated sample with a first labeling reagent comprising an azide group that can undergo a [3+2] cycloaddition reaction with the ethynyl group of the first nucleoside or nucleotide analog and a second labeling reagent that is an antibody that binds to the second nucleoside or nucleotide analog to form a labeled sample; and
d) detecting the labeled sample wherein a level of incorporation of the first nucleoside or nucleotide analog is measured and allows establishment of a baseline rate of the cellular DNA synthesis and a level of incorporation of the second nucleoside or nucleotide analog is measured,
wherein a difference between the level of incorporation of the second nucleoside or nucleotide analog relative to the baseline rate indicates a change in cellular DNA synthesis,
with the proviso that there is no wash step prior to adding the second nucleoside or nucleotide analog.
US Pat. No. 10,139,022

HEATABLE PIPE

Evonik Degussa GmbH, Ess...

1. A heatable pipe, comprising:a layer (layer I) of a moulding compound comprising a east 40 wt. % of the following components:
1) 60 to 99 parts by wt. of a partly aromatic copolyamide containing monomer units obtained from
?) 30 to 90 mol % of a combination of hexamethylenediamine and terephthalic acid, and
?) 70 to 10 mol % of a combination of hexamethylenediamine and a linear aliphatic dicarboxylic acid having 8 to 19 carbon atoms;
wherein the mol % values relate to the sum of ?) and ?) and
wherein not more than 20% of the hexamethylenediamine is optionally replaced by the equivalent amount of another diamine and/or
wherein not more than 20% of the terephthalic acid is optionally replaced by the equivalent amount of another aromatic dicarboxylic acid and/or 1,4-cyclohexanedicarboxylic acid and/or
wherein not more than 20% of the repeating units containing hexamethylenediamine and linear aliphatic dicarboxylic acid are optionally replaced by the equivalent amount of units obtained from a lactam/an ?-aminocarboxylic acid having 6 to 12 carbon atoms,
2) 40 to 1 parts by wt. of an olefinic copolymer as impact modifier,
wherein the parts by wt. of 1) and 2) sum to 100; and
a conductor for electrical current which is embedded between an electrically insulating outer layer and an electrically insulating inner layer.
US Pat. No. 10,138,512

NUCLEIC ACID PROCESSING OF A NUCLEIC ACID FRAGMENT WITH A TRIAZOLE LINKAGE

ATDBIO LIMITED, Southham...

1. A method of nucleic acid processing comprising:providing an adapted nucleic acid fragment comprising a nucleic acid fragment linked at its 3?-end to a 3?-adapter molecule by a triazole linkage comprising a 1,2,3-triazole group, wherein the 3?-adapter molecule comprises RNA, DNA, a nucleic acid analogue or combinations thereof;
annealing a primer to the adapted nucleic acid fragment, wherein the primer anneals to a region of the 3?-adapter molecule; and
processing the adapted nucleic acid fragment by transcribing at least a portion of the adapted nucleic acid fragment with reverse transcriptase, wherein said portion of the adapted nucleic acid fragment transcribed with reverse transcriptase comprises said triazole linkage.
US Pat. No. 10,137,234

METHOD FOR STERILIZING BLOOD PURIFIER AND BLOOD PURIFIER PACKAGE

NIPRO CORPORATION, Osaka...

1. A method for sterilizing a blood purifier comprising substantially dried selectively permeable separation membranes as a main component, by exposing said blood purifier to a radioactive ray and/or an electron ray, characterized in that said selectively permeable separation membranes comprise a hydrophobic polymer containing a hydrophilic polymer, said hydrophobic polymer comprises a polysulfone-based polymer, and said blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state, wherein the relative humidity (RH) in the inner atmosphere of the packaging bag at room temperature is not lower than 50% RH.
US Pat. No. 10,138,516

METHODS FOR SIMULTANEOUS AMPLIFICATION OF TARGET LOCI

Natera, Inc., San Carlos...

1. A method of amplifying target loci of DNA molecules in a nucleic acid sample, the method comprising:(a) contacting the sample and a library of at least 1,000 non-immobilized, non-identical primers that hybridize to at least 1,000 non-identical target loci to produce a reaction mixture in which the concentration of each primer is less than 20 nM; wherein the average length of the DNA molecules is less than 200 base pairs; and wherein a range of melting temperatures of the at least 1000 non-identical primers is less than 10° C.;
(b) subjecting the reaction mixture to PCR conditions to produce amplified products comprising target amplicons; wherein a length of an annealing step of the PCR conditions is greater than 10 minutes; wherein the length of the target amplicons is less than 100 nucleotides; wherein at least 1,000 different target human loci are amplified, and wherein at least 50% of the amplified products comprise target loci.
US Pat. No. 10,137,236

SELF-REGULATING DEVICE FOR MODULATING INFLAMMATION

1. A method of inhibiting tumor necrosis factor-alpha (TNF-?) comprising, providing blood of a patient to an extracorporeal bioreactor, wherein the extracorporeal bioreactor comprises: a compartment comprising cells and a selectively permeable membrane in contact with the cells that does not permit passage of the cells and which permits passage of TNF-? in the blood of the patient, wherein the cells comprise a chimeric gene comprising a response element operably linked to a sequence encoding a soluble TNF-? receptor (sTNFR), in which the response element causes expression of the sTNFR when the cells are contacted with the TNF-? in the blood of the patient; contacting the blood with the selectively permeable membrane, such that the TNF-? in the blood passes through the selectively permeable membrane and sTNFR produced by the cells passes into the blood; and returning the blood to the patient, thereby inhibiting TNF-?.
US Pat. No. 10,138,518

ANNEALING CONTROL PRIMER AND ITS USES

SEEGENE, INC., Seoul (KR...

1. An annealing control primer for improving annealing specificity in nucleic acid amplification, having the formula:5?-Xp—Yq—Zr-3?
wherein Xp represents a 5?-end portion consisting of a pre-selected arbitrary nucleotide sequence substantially not complementary to any site on a template nucleic acid;
wherein Yq represents a regulator portion consisting of 5-15 contiguous universal bases;
wherein Zr represents a 3?-end portion having a hybridizing nucleotide sequence substantially complementary to a site on the template nucleic acid to hybridize therewith;
wherein p, q and r represent the number of nucleotides;
wherein X, Y and Z is deoxyribonucleotide or ribonucleotide;
wherein the base of the deoxyribonucleotide of X is selected from the group consisting of adenine(A), cytosine(C), guanine(G) and thymine(T);
wherein the regulator portion has the lowest Tm in the three portions of the primer, whereby the regulator portion is capable of regulating an annealing portion of the primer in association with annealing temperatures; and
wherein the 5?-end portion is not involved in annealing to the template nucleic acid under conditions that the 3?-end portion anneals to the site on the template nucleic acid such that the 5?-end portion remains unhybridized with the template nucleic acid.