US Pat. No. 10,709,933

POSE AND HEART RATE ENERGY EXPENDITURE FOR YOGA

Apple Inc., Cupertino, C...

1. A method for improving the accuracy of a wearable device while calculating an energy expenditure of a user practicing yoga, the method comprising:detecting, by a processor circuit of the wearable device, a start of a yoga session;
measuring, by a heart rate sensing module of the wearable device, a heart rate of the user, wherein the heart rate sensing module comprises a photoplethysmogram (PPG) sensor and the PPG sensor is configured to be worn adjacent to the user's skin;
measuring, by a temperature sensing module of the wearable device, an ambient temperature;
collecting, by a motion sensing module of the wearable device, motion data of the user;
determining, by the processor circuit, a type of yoga practiced by the user based on the measured ambient temperature and the collected motion data;
selecting, by the processor circuit, an energy expenditure model associated with the determined type of yoga;
detecting, by the processor circuit, an end of the yoga session;
calculating, by the processor circuit, an energy expenditure of the user based on at least the measured heart rate and the selected energy expenditure model; and
outputting, by the processor circuit, the calculated energy expenditure of the user during the yoga session.

US Pat. No. 10,709,932

EXERCISE APPARATUS AND METHOD

1. An exercise apparatus for performing hip strengthening exercises comprising:(a) a chassis having a front portion and a rear portion;
(b) a cross-member movably coupled to the chassis and configured to engage the hips of a user, wherein the cross-member is configured to act against a resistance force during hip thrusts by a user;
(c) a foot platform provided towards the rear portion of the chassis;
(d) at least one resistance member coupled to the chassis and configured to be actuated by movement of the cross-member; and
(e) a variable transmission comprising at least one slider bearing disposed within at least one pair of slots defined in cooperative first and second large gears, the variable transmission configured to adjust an input force required to actuate the resistance member, wherein the variable transmission is adjustable across a range of adjustment ratios by selecting a radial position of the at least one slider bearing disposed within the at least one pair of slots defined in cooperative first and second large gears.

US Pat. No. 10,709,931

LIP TRAINER

Actwell Technology Inc., ...

1. A lip trainer, comprisinga body made from a flexible material and having a hollow annular shape, the body comprising an upper base portion, a lower base portion and two opposing connection portions connected between said upper base portion and said lower base portion at two opposite sides, said upper base portion and said lower base portion being arcuately formed;
an arced upper push piece made from a flexible material, the upper push piece having one end thereof connected to said upper base portion of said body and an opposite end thereof extending away in an arc from said upper base portion and toward said lower base portion so that a first elastic space is defined between said body and said upper push piece within the hollow annular shape; and
an arced lower push piece made from a flexible material, the lower push piece having one end thereof connected to said lower base portion of said body and an opposite end thereof extending away in an arc from said lower base portion and toward said upper base portion so that a second elastic space is defined between said body and said lower push piece within the hollow annular shape.

US Pat. No. 10,709,930

HIP THRUST EXERCISE DEVICE

1. A hip thrust exercise device, comprising:a main body having first and second body portions, the first body portion having a proximate first body portion end and a distal first body portion end;
a foot mount connected at the distal first body portion end;
a grip connected to the second body portion;
an extension having a first extension end connected at the proximate first body portion end via an extension hinge and a second extension end having an abutment element connected thereto; and
a resistance element connected between and to said extension by a first resistance element hinge and the distal first body portion end by a second resistance element hinge;
wherein said resistance element provides a resistance force when the abutment element is moved away from the distal first body portion end, and said resistance element is configured to simultaneously pivot about the first and second resistance element hinges.

US Pat. No. 10,709,929

SEATING

Joel H. Eisenberg, Pauld...

1. An apparatus for causing simultaneous posterior pelvic tilt and pivoting of at least some of the lumbar vertebrae at the intervertebral facet joints, the apparatus comprisinga base, a seat back to support at least a portion of a person's back, and a seat movable through a range of positions forward and backward relative to the base in automatic response to forces voluntarily applied by the person during typical use of the apparatus and while the person's buttocks are being supported by the seat,
the seat back comprising interconnected structural components that move relative to one another (a) in automatic response to forces voluntarily applied by the person during typical use of the apparatus and when the person's buttocks are on the seat and (b) in at least two motions that are different types of motion when the two motions are each respectively considered relative to a corresponding local frame of reference of the interconnected structural elements, at least one of the two different types of motion being a rotation backward of an upper part of the seat back about an axis that is a fixed element of the seat back, the other of the two different types of motion being a transfer downwardly of the seat back including the axis that is the fixed element, the downward transfer being other than a rotation about an axis that is a fixed element of the seat back, so that while the person simultaneously and voluntarily during typical use of the apparatus (a) has his buttocks on the seat and causes the seat to move forward relative to the base, and (b) reclines by voluntarily pressing his body against the seat or the seat back or both, the at least two different types of motions of the seat back including the rotation backward and the transfer downwardly occur automatically and independently of forward motion of the seat.

US Pat. No. 10,709,928

ABDOMINAL/BACK MUSCLE EXERCISE DEVICE

1. A stand-up abdominal/back muscle exercise device, comprising:an ankle block configured to hold ankles of the operator where in an exercise position, the ankle block having a vertical portion extending from the base and upwardly from a surface supporting the ankle block, a horizontal portion attached to and extending outwardly from the vertical portion, and at least one first receiving portion attached to the horizontal portion and configured to receive a front of the ankles of the operator where in the exercise position;
a knee block configured to receive knees of the operator where in the exercise position, the knee block disposed adjacent to and horizontally spaced apart from the ankle block, the knee block having an upright post with a bottom portion and a top portion, the bottom portion extending upwardly from the surface supporting the knee block, and the top portion angled inwardly toward the ankle block, the knee block further including at least one second receiving portion attached to the top portion of the upright post and configured to receive a rear of the knees of the operator where the operator is in the exercise position; and
an angled upper leg rest configured to hold and position a weight of the operator at a mid-thigh contact area of the operator where in the exercise position, the angled upper leg rest attached to the knee block,
wherein a section of the vertical portion of the ankle block is selectively vertically movable relative to the surface, and a section of the horizontal portion of the ankle block is selectively horizontally movable relative to the vertical portion and the knee block, and a section of the bottom portion of the knee block is selectively vertically movable relative to the surface, and
wherein the stand-up abdominal/back muscle exercise device does not have a bench or a seat for buttocks of the operator and the buttocks of the operator are unsupported by the stand-up abdominal/back muscle exercise device where the operator is in the exercise position.

US Pat. No. 10,709,927

MULTI-POSITION HORIZONTAL ELLIPTICAL CYCLE FITNESS EQUIPMENT

1. An exercise apparatus for a person to exercise on a support surface, comprising:two side frames each including a base member and a front member projecting upward from a front side of the base member, each side frame aligned and mutually fixed together at a rear cross member, a forward cross member, and a top cross member;
a crank mechanism having two cranks and fixed with the rear cross member; and
two foot members each having a foot base member with a foot pad on a top side thereof, and a foot front member projecting upward from a front side of the foot base member, each foot member pivotally fixed at a top side of the foot front member with the top cross member and pivotally fixed at a rear side of the foot base member with one of the cranks of the crank mechanism;
wherein each member of the side frames and the foot members is formed with a perforated square metal tube material having a plurality of longitudinally-aligned equally-spaced apertures formed along each side thereof;
whereby when a person rests a foot in each of the foot pads of one of the foot members, the person can perform elliptical exercises by raising and lowering his feet, holding onto the top cross member for support as desired.

US Pat. No. 10,709,926

TREADMILL

Woodway USA, Inc., Wauke...

1. A manual powered treadmill, comprising:a frame;
a front shaft assembly coupled to the frame, wherein the front shaft assembly includes a front shaft, at least one front running belt pulley coupled to the front shaft, and a first pulley coupled to the front shaft;
a rear shaft assembly coupled to the frame, wherein the rear shaft assembly includes a rear shaft, at least one rear running belt pulley coupled to the rear shaft, and a second pulley coupled to the rear shaft;
an intermediate shaft coupled to the frame, wherein the intermediate shaft is disposed intermediate the front shaft assembly and the rear shaft assembly, wherein the intermediate shaft includes a first intermediate pulley and a second intermediate pulley, wherein the first intermediate pulley is coupled to the first pulley of the front shaft assembly by a first belt, wherein the second intermediate pulley is coupled to the second pulley of the rear shaft assembly by a second belt, such that the intermediate shaft is coupled to each of the front and rear shaft assemblies such that a rotational speed of the at least one front running belt pulley substantially matches a rotational speed of the at least one rear running belt pulley;
a running belt disposed about the front and rear shaft assemblies and at least one of the front and rear running belt pulleys, wherein the running belt defines at least a portion of a non-planar running surface; and
a safety device coupled to the intermediate shaft, the safety device operable to substantially prevent movement of the running belt in a first direction and to permit movement of the running belt in a second direction opposite the first direction.

US Pat. No. 10,709,925

STRENGTH TRAINING APPARATUS

1. A strength training apparatus comprising:a tower;
a first arm and a second arm each pivotally coupled with the tower and each being configured to be selectively positionable independent of each other at multiple angles relative to each other;
a first pulley coupled to an end of the first arm;
a first cable extending through the first arm and the first pulley;
a second pulley coupled to an end of the second arm;
a second cable extending through the second arm and the second pulley;
a magnetic mechanism coupled to the first cable and the second cable and configured to provide multiple levels of resistance to a user pulling on the first cable and/or the second cable; and
a control panel located on the tower, the control panel including:
a processor and a memory configured to control a current level of resistance provided by the magnetic mechanism,
an input device configured to allow the user to set the current level of resistance provided by the magnetic mechanism, and
an output device configured to display the current level of resistance provided by the magnetic mechanism.

US Pat. No. 10,709,924

SQUAT BAR FOR FITNESS MACHINE

FLEXLINE FITNESS, INC., ...

2. An exercise system, comprising:a) a frame, wherein the frame comprises a first vertical frame and a second vertical frame, each vertical frame having a top end and a bottom end;
b) a pulley system operatively coupled to the frame, the pulley system comprising:
i) a plurality of pulley wheels,
ii) a drive mechanism operatively coupled to the plurality of pulley wheels, and
iii) an exercise bar operatively coupled to the drive mechanism;
c) a resistance machine operatively coupled to the exercise bar via the drive mechanism, the resistance machine having a resistive force configured to counter a pulling force on the drive mechanism by a user moving the exercise bar; and
d) a controller operatively connected to the resistance machine to adjust the resistive force, wherein the exercise bar comprises a plurality of gas input actuators and a plurality of gas release actuators to accommodate accessibility to the plurality of gas input actuators and the plurality of gas release actuators when the user uses a wide grip or a narrow grip on the exercise bar, wherein the exercise bar comprises a first adjustment button operatively connected to the controller to adjust the resistive force, and a second adjustment button operatively connected to the controller to adjust the resistive force, wherein the first adjustment button is a first gas input actuator of the plurality of gas input actuators and the second adjustment button is a first gas release actuator of the plurality of gas release actuators, wherein the controller is operatively connected to the first gas input actuator and the first gas release actuator, wherein actuation of the first gas input actuator causes the controller to increase the resistive force, wherein actuation of the first gas release actuator causes the controller to decrease the resistive force, wherein the exercise bar has a first section and a second section opposite the first section, wherein the first section has the first adjustment button and the second section has the second adjustment button, and wherein the first section and the second section are removably attached to each other at a connection joint.

US Pat. No. 10,709,923

APPARATUS FOR MOTOR REHABILITATION OF UPPER AND LOWER LIMBS

1. An apparatus for motor rehabilitation of upper and lower limbs, the apparatus comprising:a robotic arm having a proximal robotic arm end and terminating in a distal robotic arm end, the robotic arm including a larger rod, having a length between about 1 cm and about 100 cm, and a smaller rod, having a length between about 5 cm and about 50 cm;
an adapter connected to the distal robotic arm end, and configured for connection to a distal end of the upper or lower limb;
a gear system operatively coupled to the proximal robotic arm end, the gear system including two opposing gears, a spider gear, and a connection element;
two motors operatively coupled to the gear system, each of the two motors configured to directly drive one of the two opposing gears and both of the two opposing gears configured to drive the spider gear;
at least one driver in electrical communication with the motors;
virtual or augmented reality software;
a management and control system in communication with the at least one driver and the virtual or augmented reality software;
a display in communication with the virtual or augmented reality software;
wherein, the apparatus is configured to move the robotic arm in three-dimensional space with curvilinear trajectories; and,
wherein, when only the distal end of the upper or lower limb is connected to the apparatus, the limb is suspended in space.

US Pat. No. 10,709,921

ASSEMBLY DEVICE AND SYSTEM FOR AN EXERCISE STRUCTURE, AND ASSOCIATED EXERCISE SYSTEM AND MOUNTING METHOD

1. A sport exercise system comprising:a sports exercise structure (1) including at least one hole (10);
an accessory;
a male connector; and
an assembly device (5) of said accessory to said structure (1), said device (5) including:
at least one hollow main body (51) which extends longitudinally between two ends, which is provided with at least a first opening (511) and which is configured to be inserted into said hole (10) and to removably receive said male connector, said male connector configured to be inserted into said hollow main body (51) through the first opening (511) in order to connect said accessory and assembly device, said main body (51) delimiting a continuous empty inner volume opening at each end to form respectively said first opening (511) and a second opening (516); and
a first removable plug (53) configured to seal said first opening (511) when the male connector is not inserted into said hollow main body (51),
the main body (51) comprising a tubular side wall (514) having an inner surface (517) configured to face the male connector and an opposite outer surface (518), and at least one lug (56, 57) which protrudes from said outer surface (518).

US Pat. No. 10,709,920

JUMP ROPE HANDLE HAVING ROPE HINGE

Web Guidz, LLC, Wenatche...

1. A jump rope handle, comprising:a grip extending along a first axis;
a head rotationally coupled to the grip, wherein the head rotates about the first axis, and the head includes:
a fork having a first prong and a second prong; and
a pivot hole extending along a second axis and through the first prong and the second prong;
a rope hinge rotationally coupled to the head and mounted in the pivot hole in the first prong and the second prong to constrain movement of the rope hinge to a single degree of freedom relative to the head, wherein the single degree of freedom is rotation of the rope hinge about the second axis, and the rope hinge includes:
a rope hole extending through the rope hinge along a third axis orthogonal to the second axis; and
wherein the rope hole extends through the rope hinge between the first prong and the second prong.

US Pat. No. 10,709,919

FIRE SUPPRESSION SYSTEMS AND METHODS

Tyco Fire Products LP, L...

1. A vehicle fire suppression system comprising:a centralized controller;
at least one input bus coupled to the centralized controller, the input bus providing for connecting analog and digital devices to the centralized controller;
at least one output bus coupled to an extinguishment supply and an actuating device for releasing extinguishment from the extinguishment supply, the actuating device being coupled to the centralized controller; and
a manual actuating device coupled to the input bus for communication with the centralized controller to electrically signal the actuating device on the output bus to provide for manual actuation via an electrical signal,
wherein the centralized controller is a programmable controller including internal circuitry to detect the status of at least one of the input bus and output bus, further comprising a fire detection circuit coupled to the at least one input bus, the internal circuitry detecting the status of the at least one input bus so as to discern between: a fault condition, a sensed detection, and a manual release along the fire detection circuit depending upon a single variable resistance in the internal circuitry of the programmable controller; and
wherein the fault condition corresponds to a first range of resistance values of the variable resistance, wherein the sensed detection corresponds to a second range of resistance values of the variable resistance, and wherein the manual release corresponds to a third range of resistance values of the variable resistance.

US Pat. No. 10,709,917

CONCRETE STRUCTURE BODY FOR CONSTRUCTING BUILDING FLOOR, HAVING FIREFIGHTING FUNCTION, AND BUILDING FLOOR CONSTRUCTION STRUCTURE INCLUDING SAME

ROOMSTAR CO., LTD., Yeon...

1. A concrete structure for constructing a building floor, the concrete structure being a concrete structure for forming a building floor, and comprising:a concrete main body to store fire-extinguishing water for fire suppression; and
a fire-extinguishing water injection unit to inject the fire-extinguishing water stored in the concrete main body,
wherein the concrete main body comprises:
a base plate;
a barrier protruding upward from the base plate; and
a plurality of fire-extinguishing water cells formed by the barrier and storing fire-extinguishing water, and
wherein the fire-extinguishing water injection unit comprises:
a fire-extinguishing water container embedded in each fire-extinguishing water cell of the concrete main body and storing the fire-extinguishing water;
a fire-extinguishing water discharge pipe to discharge the fire-extinguishing water stored in the fire-extinguishing water container embedded in each fire-extinguishing water cell of the concrete main body; and
a fire-extinguishing water injector installed at an end of the fire-extinguishing water discharge pipe and injecting the fire-extinguishing water.

US Pat. No. 10,709,916

INTEGRATED PANEL FOR FIRE SUPPRESSION SYSTEM

1. An integrated fire suppression system comprising:a cabinet including a plurality of defined and isolated compartments;
a first walled compartment receiving and mounting a plurality of fire suppression control systems including at least one of electrical components and controls for a water solenoid, high pressure tank nozzle, and an emitter nozzle;
a second walled compartment having fluid storage and high pressure components and providing isolation of fluid between the first and second walled compartments;
a third walled compartment disposed within the cabinet further including a solenoid and actuator of the fire suppression control systems disposed within the third walled compartment, the third walled compartment providing environmental isolation with respect to the first and second walled compartments;
at least one opening between the first walled compartment and the second walled compartment;
the at least one opening further including a sealing mechanism to provide isolation between the first and second walled compartments; and
a high pressure tank disposed in both the first and second walled compartments and a portion of the tank including a nozzle extending through the at least one opening into the second walled compartment.

US Pat. No. 10,709,915

FULL CONE SPRAY NOZZLE FOR A LOW PRESSURE FIRE PROTECTION SYSTEM

VID FIRE-KILL APS, Svend...

1. A fire protection system comprising:at least one low pressure water mist nozzle in operable communication with a fire protection system configured to supply water through said at least one low pressure water mist nozzle at supply water pressures of 0.5 bar to 20 bars,
wherein the low pressure water mist nozzle has a housing and a single separation wall (3) having both a centrally located opening (7) and multiple openings (4) of sizes 1 mm to 2.5 mm diameter, and wherein the multiple openings are at angles of 10° to 50° to the wall surfaces, the separation wall (3) is followed by a cavity (8) having a centrally located outlet opening (6) in its end wall (5), both the centrally located opening (7) and the multiple openings (4) extend between an inlet port (2) and the cavity (8), the end wall (5) is located immediately downstream of the separation wall (3) containing both the centrally located opening (7) and the multiple openings (4),
wherein a surface of the end wall (5) facing the cavity (8) is conical,
wherein the end wall and the housing are monolithic,
wherein a thickness of the separation wall (3) is smaller than a length defined between the separation wall and the end wall (5),
wherein the centrally located outlet opening (6) of the end wall (5) has a continuous nozzle surface defining an increasing cross-sectional area, and wherein the continuous nozzle surface is curved radially outwardly relative to a longitudinal axis of the nozzle, and
wherein the cavity (8) is cylindrical in its entire length between the separation wall (3) and the conical end surface (5).

US Pat. No. 10,709,914

AUTOMATIC FIRE SPRINKLERS, SYSTEMS AND METHODS FOR SUPPRESSION FIRE PROTECTION OF HIGH HAZARD COMMODITIES INCLUDING COMMODITIES STORED IN RACK ARRANGEMENTS BENEATH CEILINGS OF UP TO FIFTY-FIVE FEET IN HEIGHT

Viking Group, Inc., Cale...

1. A ceiling-only storage occupancy fire protection system comprising:a grid of pendent fire protection sprinklers defining a sprinkler-to-sprinkler spacing ranging from eight feet to twelve feet (8 ft.-12 ft.), each pendent sprinkler being qualified to suppress a fire in a storage commodity, each sprinkler including:
a sprinkler body having an inlet and an outlet with a passageway disposed therebetween along a sprinkler axis and a nominal K-factor of 22.4 [GPM/(psi)1/2] to 36.4 [GPM/(psi)1/2];
a closure assembly including a plug;
a thermally responsive trigger assembly to support the closure assembly adjacent the outlet of the sprinkler body, the trigger assembly having a response time index (RTI) ranging from 19 to 36 (m*s)1/2 [35-65 (ft.*s)1/2] and a temperature rating in a range of 155° F. to 210° F.; and
a deflector coupled to the body and spaced from the outlet; anda network of pipes including at least one main pipe and a plurality of spaced apart branch lines interconnecting and locating the grid of pendent sprinklers beneath a ceiling having a ceiling height, the network of pipes being filled with a firefighting fluid and locating the grid of sprinklers relative to a source of the firefighting fluid in which a number of hydraulically most remote sprinklers in the grid of sprinklers define a hydraulic design area of the system, the network of pipes delivering to each sprinkler in the hydraulic design area at least a minimum flowing pressure of forty to one hundred pounds per square inch (40-100 psi.) upon sprinkler actuation in order to provide suppression protection of high-piled storage including at least one commodity including any one of Class 1, Class 2, Class 3, Class 4 and cartoned unexpanded plastic commodities and combinations thereof, stored beneath the ceiling, the at least one commodity having a maximum storage height, the storage having a configuration of at least rack storage, the rack storage being any one of single-row, double-row, and multi-row rack storage;wherein the number of hydraulically most remote sprinklers defining the hydraulic design area is nine (9) or ten (10) and the ceiling has a ceiling height of up to a maximum fifty-five feet (55 ft.) and the at least one commodity has a maximum storage height of fifty feet (50 ft.);
wherein the hydraulically most remote sprinklers defining the hydraulic design area comprise at least a first group of three sprinklers on a first branch line, a second group of three sprinklers on a second branch line, a third group of three sprinklers on a third branch line, the first, second, and third branch lines being separate branch lines of the plurality of spaced apart branch lines.

US Pat. No. 10,709,913

FALL RESTRAINT SYSTEM

Auburn University, Aubur...

1. A system for fall restraint, comprising:a mounting frame;
a trigger mechanism having a trigger movably mounted to the mounting frame, wherein the trigger mechanism is operably coupled to a plurality of firing pins, and wherein the trigger mechanism is operably coupleable to a user; and
a plurality of anchors extendable from the mounting frame upon actuation of the trigger mechanism.

US Pat. No. 10,709,912

NASAL CAVITY INSERTION TYPE MASK

AirLab CO., Ltd., Jeonju...

1. A nasal cavity insertion type mask inserted into a nose to filter external air inhaled upon breathing, the nasal cavity insertion type mask, comprising:a body formed in a cone shape having a gradually reducing diameter in an upward direction in order to deeply insert into a nasal cavity and formed in a form in which an upper portion, a lower portion, and a side surface are opened for smooth communication of air;
a filter detachably provided at an outer surface of the body and that filters a foreign substance included in external air; and
a fixing tube that comes in close contact a portion of the filter with the body and that fixes a portion of the filter to the body in order to prevent the filter disposed to enclose an outer surface of the body from being separated from the body and that provides a double wall configuration comprising an inner wall and an outer wall and that prevents a snot of a nasal cavity inner wall from contacting the filter, as the outer wall is formed higher than the inner wall and comprising a snot receiving portion that can receive a snot flowing along the nasal cavity inner wall.

US Pat. No. 10,709,911

SURGICAL HELMET

Zimmer Surgical, Inc., D...

1. A surgical helmet assembly, comprising:an interchangeable protective garment comprising a shield and a covering, the shield adapted to be coupled to the covering, and the covering for providing a barrier between at least a head and shoulders of a user and a surgical field;
a surgical helmet to be worn on the head of the user, comprising:
a main helmet upper body comprising a non-airflow conducting cage structure positionable superior of the head of the user;
an elongate arcuate brow bar located below the main helmet upper body and having a length configured to extend medial-laterally across a forehead of the user between temple regions of the head of the user on both sides of the head and extend to rear regions of the head of the user on both sides of the head;
an arcuate chin bar configured to be disposed anterior of a chin of the user and extend from a portion of the main helmet upper body superior and posterior of the user's ears and pass posterior of the user's ears to the brow bar in use so the chin bar leaves the user's ears uncovered laterally when the covering of the interchangeable protective garment is removed, the chin bar comprising an anterior airflow outlet disposed in an upper surface of an anterior portion of the chin bar and an airflow channel extending from rear regions of the brow bar through the arcuate chin bar from superior and posterior of the user's ears to the anterior airflow outlet;
hook-and-loop material anchors located on the brow bar and the chin bar and positioned to attach to mating hook-and-loop material anchors on the shield;
a fan mounted to the surgical helmet at the rear regions of the brow bar above the brow bar and the arcuate chin bar;
a front airflow outlet positioned to receive air from the fan via the brow bar and configured to discharge airflow onto the forehead of the user;
a rear airflow outlet positioned to receive air from the fan and configured to discharge airflow onto the neck of the user; and
an airflow inlet located in an inlet cover mounted to the fan;
wherein the airflow channel is structured such that the airflow inlet and the anterior airflow outlet are in direct fluidic communication with each other so that the fan draws air through the airflow inlet and then pushes the air downward through the airflow channel and the brow bar and then out through the anterior airflow outlet of the chin bar and front airflow outlet of the brow bar; and
a light assembly comprising:
a light source mounted to the surgical helmet in an articulable manner; and
an adjustment arm connected to the light source to articulate the light source between a first position and a second position, the adjustment arm comprising a single lever directly connecting the light source to a knob positioned outside of the cage structure.

US Pat. No. 10,709,910

METHOD FOR THE CONTROL OF THE BREATHING GAS SUPPLY

9. A system for controlling an emergency oxygen supply in a passenger aircraft, the system comprising:a valve disposed between an oxygen source and a plurality of breathing masks;
a means for measuring mass flow disposed between the valve and the plurality of breathing masks; and
processing circuitry configured to
determine a desired mass flow,
monitor over time an actual mass flow based upon measurements supplied by the means for measuring mass flow, and
control opening and closing of the valve, during monitoring, as a function of the desired mass flow and the actual mass flow by:
determining a minimal error value and a maximal error value;
causing actuation of the valve to a closed position when a difference between the actual mass flow and the desired mass flow exceeds the maximal error value; and
causing actuation of the valve to an open position when a difference between the desired mass flow and the actual mass flow exceeds the minimal error value.

US Pat. No. 10,709,909

NOZZLE FOR RETRACTABLE FALL ARREST

RELIANCE INDUSTRIES, LLC,...

1. A nozzle for a retractable fall arrest device, said nozzle defining a passage, said passage configured to have a cable of the retractable fall arrest device supporting a user passing through said nozzle, said passage extends through the nozzle between a top surface and a bottom surface of the nozzle and defines a passage axis; said passage having an elongate entrance and an elongate exit; said passage defining a constricted portion, a horizontal cross-section of said constricted portion extending substantially perpendicular to said passage axis, said constricted portion having opposed end sections and a middle section; said end sections of said constricted portion defining a width greater than a width of the middle section of said constricted portion; wherein the width of the middle section of said constricted portion is less than a width of at least one of said entrance and exit to said passage; and wherein a perimeter of said passage defines a plane which intersects said passage axis at an angle greater than zero.

US Pat. No. 10,709,906

COUPLING ARRANGEMENTS AND METHODS FOR ATTACHING TOOLS TO ULTRASONIC SURGICAL INSTRUMENTS

Ethicon LLC, Guaynabo, P...

1. An ultrasonic surgical instrument, comprising:an ultrasonic transducer;
an ultrasonic end effector comprising a proximal end formed of a first material having a first coefficient of thermal expansion; and
a waveguide configured to transmit ultrasonic energy generated by the ultrasonic transducer to the ultrasonic end effector, wherein the waveguide includes an attachment portion formed of a second material having a second coefficient of thermal expansion that is greater than the first coefficient of thermal expansion, the attachment portion configured to be selectively expandable into an acoustically coupled retaining engagement with the ultrasonic end effector by expanding faster than the proximal end of the ultrasonic end effector when heat is applied to establish an interference fit therebetween.

US Pat. No. 10,709,905

METHOD OF CALCULATING A TONGUE-AND-GROOVE EFFECT OF A MULTI-LEAF COLLIMATOR

1. An improved method of calculating a radiation dose for a radiation treatment using a multi-leaf collimator for patients that will be treated with radiation therapy using the multi-leaf collimator comprising:providing a multi-leaf collimator comprising leaves of a tongue-and-groove design, the leaves having lateral edges and tip ends, wherein the lateral edges will be exposed to radiation during a treatment protocol,
testing the multi-leaf collimator to determine a shape of a tongue-and-groove width, and
subtracting the shape of the tongue-and-groove width from a fluence map used for radiation dose calculations,
wherein an amount subtracted depends on a distance from a tip end of each leaf to a point on each leaf, and
wherein the amount subtracted comprises a non-constant width at the lateral edges of the leaves that are exposed to radiation and a constant transmission through the non-constant width is considered.

US Pat. No. 10,709,904

APPARATUS FOR PERFORMING NANOPARTICLE-ASSISTED EXTERNAL BEAM RADIOTHERAPY AND METHOD CARRIED OUT USING SAID APPARATUS

1. An apparatus for performing nanoparticle-assisted external beam radiotherapy comprising:an X-ray spectrometer having an optical axis;
an X-ray filter; and
a mobile holding structure suitable for holding the X-ray filter and the X-ray spectrometer in a first and a second relative position, and for switching from said first to said second relative position while simultaneously allowing the positioning of a patient body part in a target region including a target point;
wherein:
the first and second relative positions of the X-ray filter and the X-ray spectrometer are such that an X-ray beam emitted from an X-ray source crosses the X-ray filter before reaching the target point, a propagation direction of the X-ray beam forming an angle ? different from 0° and 180° with the optical axis of the X-ray spectrometer; and
the second relative position is obtained by inverting the relative positions of the X-ray filter and of the X-ray spectrometer with respect to the patient body part.

US Pat. No. 10,709,903

GANTRY IMAGE GUIDED RADIOTHERAPY SYSTEM AND RELATED TREATMENT DELIVERY METHODS

ACCURACY INCORPORATED, S...

15. A non-transitory machine readable medium that, when executed by a processing unit, cause the processing unit to: translate a radiation treatment head movably mounted to a beam member of a gantry structure; gimbal, by the processing unit, the radiation treatment head relative to the gantry structure, the gimballing comprising pivotably moving the radiation treatment head in at least one independent pivot direction defined with respect to the gantry structure; and move a patient couch relative to the radiation treatment head; wherein the processing unit further configured to gimbal the radiation treatment head with a maximum angle greater than +/?30 degrees.

US Pat. No. 10,709,902

TANDEM WITH CAMERA SYSTEM AND METHOD

1. A tandem applicator assembly for brachytherapy, comprising:a tandem having a tubular main body with a trail end and a lead end, a transparent cap affixed to the lead end;
a camera system removably received by the tandem through the trail end of the tubular main body and disposed inside of the transparent cap, wherein the camera system includes at least one digital camera configured to acquire color images from a body cavity of a patient through the transparent cap and a main body having a camera portion with at least one lens, the at least one digital camera disposed inside of the main body beneath the at least one lens, the at least one digital camera configured to acquire the color images of the patient through both the at least one lens and the transparent cap; and
an insertion and removal line coupled to the camera system and configured to selectively advance and retract the camera system through the tandem,
wherein the main body of the camera system further has a transmitter in communication with a processor and a memory, the transmitter configured to generate a wireless signal with image data from the at least one camera, and
wherein a portion of the transmitter abuts an inner surface of the tandem, and thereby causes the tubular main body of the tandem to be an antenna of the transmitter for transmission for the wireless signal.

US Pat. No. 10,709,901

IMPLANTABLE FASTENERS, APPLICATORS, AND METHODS FOR BRACHYTHERAPY

Covidien LP, Mansfield, ...

1. A fastener applicator comprising: a body portion including a handle assembly;a cartridge assembly supported within the body portion, the cartridge assembly including implantable fasteners, at least one implantable fastener having:
a body including a backspan having a tissue facing surface;
a tissue penetrating portion extending from the body, the tissue penetrating portion including:
a first leg having first and second portions and a first connecting portion interconnecting the first and second portions, the first portion extending from a first end portion of the backspan and coupled to the second portion extending towards the backspan; and
a second leg having third and fourth portions and a second connecting portion interconnecting the third and fourth portions, the third portion extending from a second end portion of the backspan and coupled to the fourth portion, the first and third portions of the respective first and second legs extending away from the backspan at an angle such that the first and third portions of the respective first and second legs overlap one another, the backspan being spaced apart from the first and second connecting portions of the respective first and second legs in an unformed condition, and the backspan and the first and third portions of the respective first and second legs being parallel to each other in a formed condition; and
a capsule affixed to the tissue facing surface of the body, the capsule including radioactive material;
a drive assembly supported within the body portion and operatively coupled to the cartridge assembly to engage the implantable fasteners; and
an actuation assembly supported within the handle assembly and operatively coupled to the drive assembly to fire a distal-most implantable fastener upon actuation of the actuation assembly.

US Pat. No. 10,709,898

LIGHT IRRADIATING DEVICE AND PHOTOTHERAPY MACHINE

SHARP KABUSHIKI KAISHA, ...

1. A light irradiating device comprisinga group of LED light sources that has at least one LED light source two-dimensionally arranged on a flexible substrate, wherein
light output by the group of LED light sources includes
first wavelength region light whose light-emission intensity peak is in a wavelength range of 380 nm or more and 430 nm or less, and
second wavelength region light whose light-emission intensity peak is in a wavelength range of more than 430 nm and 635 nm or less,
the at least one LED light source includes
a first LED element that outputs the first wavelength region light, and
a wavelength conversion member that absorbs the first wavelength region light output from the first LED element and outputs the second wavelength region light,
at least one layer of a spacer is provided on a light-output-side surface of the flexible substrate in which the first LED element is two-dimensionally arranged,
of the at least one layer of the spacer, at least one layer of a spacer is a spacer that contains the wavelength conversion member, and
a total value of thicknesses of constituents provided from the first LED element to an affected part is 0.5 times or more an average value of pitches between first LED elements.

US Pat. No. 10,709,897

TREATMENT INTERVALS FOR USE OF COMPOSITIONS COMPRISING ENERGY ABSORBING MATERIALS FOR DERMATOLOGICAL APPLICATIONS

Sebacia, Inc., Duluth, G...

1. A method of at least one of treating and ameliorating acne vulgaris in a subject, the method comprising:a. a first phase of treatment, said first phase of treatment comprising:
i. topically applying a first formulation comprising plasmonic nanoparticles in a hydrophilic solution to a subject's skin of a face or an upper trunk, said first formulation having an optical density of between about 5 and about 500;
ii. mechanically agitating said first formulation on said skin to facilitate delivery of said nanoparticles to at least one of the group of a hair follicle, a sebaceous gland, a sebaceous gland duet, and an infundibulum of the skin; and
iii. irradiating said nanoparticles with light having a wavelength between about 700 and about 1,100 nm that is absorbed by said nanoparticles, thereby heating said skin local to said nanoparticles for at least one of treating and ameliorating acne vulgaris; and
b. a second phase of treatment, said second phase of treatment comprising:
i. between about 23 hours and 14 days after said irradiating step of said first phase of treatment:
a. topically applying a second formulation comprising said nanoparticles to said subject's skin, said second formulation having an optical density of between about 5 and about 500;
b. mechanically agitating said second formulation on said skin to facilitate delivery of said nanoparticles to at least one of the group of a hair follicle, a sebaceous gland, a sebaceous gland duct, and an infundibulum of the skin; and
c. irradiating said nanoparticles with light having a wavelength between about 700 and about 1,100 nm that is absorbed by said nanoparticles, thereby heating said skin local to said nanoparticles for at least one of treating and ameliorating acne vulgaris.

US Pat. No. 10,709,896

SYSTEM AND METHOD FOR TREATING HEMORRHOIDS

Biolitec Unternehmensbete...

1. A minimally invasive system for treating both the cause and symptoms of hemorrhoids, comprising:a radiation source;
a handpiece;
a radiation distributing probe comprising a first channel and a second channel; said radiation distributing probe having a longitudinal axis and being rotatably connected to said handpiece;
an optical fiber connected to said radiation source and disposed in said first channel, said optical fiber comprising a distal tip directed perpendicularly to said longitudinal axis of said radiation distributing probe; and
an imaging probe disposed in said second channel, said imaging probe comprising a distal tip configured to image perpendicularly to said longitudinal axis of said radiation distributing probe;
said radiation distributing probe comprising a manual locking mechanism disposed about said radiation distributing probe, said locking mechanism being configured to rotate with respect to said handpiece to lock said radiation distributing probe in only a first fixed rotational position or a second fixed rotational position whereby said radiation distributing probe is configured to rotate between only said first fixed rotational position and said second fixed rotational position with respect to said handpiece, said first fixed rotational position and said second fixed rotational position being 180 degrees from each other such that the positions of the distal tip of said optical fiber and the distal tip of said imaging probe are configured to be manually rotated 180 degrees to exactly switch places with each other without moving said handpiece.

US Pat. No. 10,709,895

AESTHETIC METHOD OF BIOLOGICAL STRUCTURE TREATMENT BY MAGNETIC FIELD

BTL Medical Technologies ...

1. A method for toning a body region of a patient by applying a treatment using a treatment device which generates a time-varying magnetic field, the method comprising:coupling a first applicator and a second applicator of the treatment device to the body region of the patient by a belt,
wherein the body region comprises one of a buttocks or an abdomen,
wherein the first applicator has a first magnetic field generating coil disposed in the first applicator and the second applicator has a second magnetic field generating coil disposed in the second applicator,
wherein the first magnetic field generating coil has a first inductance and the second magnetic field generating coil has a second inductance, wherein the first inductance is equal to the second inductance, and
wherein the first applicator and the second applicator are independently positionable, and independently coupled to the body region of the patient by the belt;
charging a first capacitor and a second capacitor of the treatment device;
discharging the first capacitor to the first magnetic field generating coil to generate a first time-varying magnetic field having a magnetic flux density in a range of 0.5 Tesla to 7 Tesla, an impulse duration in a range of 3 ?s to 1 ms, and a maximal value of a magnetic flux density derivative in a range of 0.5 kT/s to 400 kT/s;
discharging the second capacitor to the second magnetic field generating coil to generate a second time-varying magnetic field having a magnetic flux density in a range of 0.5 Tesla to 7 Tesla, an impulse duration in a range of 3 ?s to 1 ms, and a maximal value of a magnetic flux density derivative in a range of 0.5 kT/s to 400 kT/s;
generating a plurality of pulses of the first time-varying magnetic field;
generating a first pulse of the first time-varying magnetic field such that the first pulse lasts for a time period, wherein the time period lasts from a beginning of a first impulse of the first time-varying magnetic field to a beginning of a next consecutive impulse of the first time-varying magnetic field;
generating a second pulse of the second time-varying magnetic field such that the second pulse lasts from a beginning of a first impulse of the second time-varying magnetic field to a beginning of a next consecutive impulse of the second time-varying magnetic field, such that the first impulse of the second time-varying magnetic field is generated during the time period of the first pulse,
wherein the plurality of pulses of the first time-varying magnetic field comprises a first plurality of pulses, a second plurality of pulses, and a third plurality of pulses,
wherein the first plurality of pulses comprises a first repetition rate in a range of 1 Hz to 100 Hz,
wherein the second plurality of pulses comprises a second repetition rate in a range of 10 Hz to 30 Hz, and wherein the first repetition rate differs from the second repetition rate,
wherein the third plurality of pulses comprises a third repetition rate, wherein the third repetition rate differs from the first repetition rate and the second repetition rate,
wherein the impulses are sinusoidal and biphasic; and
applying the first time-varying magnetic field including the first, the second, and the third pluralities of the pulses of the first time-varying magnetic field to a muscle fiber, a neuromuscular plate, or muscle within the body region of the patient such that a muscle contraction within the body region is caused by each of the first, the second, and the third pluralities of the pulses of the first time-varying magnetic field.

US Pat. No. 10,709,894

AESTHETIC METHOD OF BIOLOGICAL STRUCTURE TREATMENT BY MAGNETIC FIELD

BTL Medical Technologies ...

1. A device for treating muscles of a patient, comprising:a first applicator comprising a first a magnetic field generating device, the first magnetic field generating device comprising a first magnetic coil;
a second applicator comprising a second magnetic field generating device, the second magnetic field generating device comprising a second magnetic coil;
a first energy source connected to the first magnetic field generating device;
a second energy source connected to the second magnetic field generating device;
a first energy storage device connected to the first magnetic field generating device and configured to be charged by the first energy source;
a second energy storage device connected to the second magnetic field generating device and configured to be charged by the second energy source;
a first switching device configured to discharge the first energy storage device to the first magnetic field generating device to generate a first time-varying magnetic field;
a second switching device configured to discharge the second energy storage device to the second magnetic field generating device to generate a second time-varying magnetic field;
a control unit configured to regulate the first energy source, the second energy source, the first switching device, and the second switching device; and
a belt configured to couple the first applicator to a first body region of the patient and to couple the second applicator to a second body region of the patient,
wherein the first time-varying magnetic field and the second time-varying magnetic field each comprise:
a first plurality of magnetic pulses having a first duration and a first repetition rate;
a second plurality of magnetic pulses having a second duration and a second repetition rate and
a third plurality of magnetic pulses having a third duration and a third repetition rate,
wherein the first pluralities of magnetic pulses of each of the first and second time-varying magnetic fields, respectively, have an incrementally increasing magnetic flux density,
wherein the second pluralities of magnetic pulses of each of the first and second time-varying magnetic fields, respectively, have a constant magnetic flux density,
wherein the third pluralities of magnetic pulses of each of the first and second time-varying magnetic fields, respectively, have an incrementally decreasing magnetic flux density,
wherein the first, second, and third pluralities of magnetic pulses of each of the first and second time-varying magnetic fields, respectively, comprise biphasic sinusoidal magnetic impulses, and
wherein each of the first, second, and third impulse durations of each of the first, second, and third pluralities of magnetic pulses of each of the first and second time-varying magnetic fields, respectively, are within a range of from 3 ?s to 1 ms, and
wherein the first switching device and the second switching device are configured to synchronously discharge the first energy storage device to the first time-varying magnetic field and the second energy storage device to the second time-varying magnetic field, respectively.

US Pat. No. 10,709,893

SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION

BOSTON SCIENTIFIC NEUROMO...

1. A system for programming an electrical tissue stimulator coupled to an array of electrodes, comprising:a display screen; and
at least one processor configured for
receiving a user input of a modification of a stimulation parameter set that, when applied to the electrodes, will shift electrical current between the electrodes to modify a region of tissue activation,
in response to the user input of the modification, automatically computing an estimate of the modified region of tissue activation based on the modification of the stimulation parameter set, and
in response to the user input of the modification and the computing of the estimate, automatically generating display signals capable of prompting the display screen to display an animated graphical representation of a shift of the region of tissue activation to the computed estimate of the modified region of tissue activation such that the user perceives the modification of the stimulation parameter set as movement, in a continuous or flickering manner, of the region of tissue activation through a series of intermediate depictions to the computed estimate of the modified region of tissue activation.

US Pat. No. 10,709,892

TEMPORAL CONFIGURATION OF A MOTION SENSOR IN AN IMPLANTABLE MEDICAL DEVICE

CARDIAC PACEMAKERS, INC.,...

1. A method of operating an implantable device (ID) adapted for disposition within the heart of a patient, the ID comprising a motion sensor for detecting movement of the patient, the method comprising:initializing the ID by:
contemporaneously collecting a set of data points from the motion sensor and from a cardiac electrical signal;
correlating time periods within the set of data points from the motion sensor to cardiac activity reflected by the cardiac electrical signal; and
configuring the ID to capture data from the motion sensor by reference to specific repeatable elements of the cardiac electrical signal;
using the ID as configured in the initializing step to capture cardiac signals of the patient and motion signals for the patient.

US Pat. No. 10,709,891

SYSTEMS, APPARATUSES AND METHODS FOR DELIVERY OF ABLATIVE ENERGY TO TISSUE

Farapulse, Inc., Menlo P...

1. A system, comprising:a pulse waveform generator operatively coupled to an ablation device, the pulse waveform generator configured to:
select electrode sets from a plurality of electrodes of the ablation device, each electrode set including a first subset of electrodes configured as one or more anodes and a second subset of electrodes configured as one or more cathodes;
generate voltage pulses in the form of pulsed waveforms, each pulsed waveform including:
(a) a first level of a hierarchy of the pulsed waveform that includes a first set of pulses and a first time delay separating successive pulses of the first set of pulses;
(b) a second level of the hierarchy of the pulsed waveform that includes a plurality of first sets of pulses as a second set of pulses and a second time delay separating successive first sets of pulses, the second time delay being at least three times the duration of the first time delay; and
(c) a third level of the hierarchy of the pulsed waveform that includes a plurality of second sets of pulses as a third set of pulses and a third time delay separating successive second sets of pulses, the third time delay being at least thirty times the duration of the second level time delay; and
apply the voltage pulses to the electrode sets according to a predefined sequence with at least one pulsed waveform being applied across the first and second subsets of electrodes of each electrode set.

US Pat. No. 10,709,890

ALTERNATIVE ELECTRODE CONFIGURATIONS FOR REDUCED POWER CONSUMPTION

Medtronic Bakken Research...

1. A method comprising:identifying, by processing circuitry, an initial electrode combination configured to deliver electrical stimulation therapy via a lead, the lead comprising a plurality of electrodes arranged in a complex electrode array geometry, wherein the initial electrode combination comprises one or more electrodes of the plurality of electrodes;
determining, by the processing circuitry and based on the one or more electrodes of the initial electrode combination, a plurality of alternative electrode combinations for delivering electrical stimulation therapy, wherein each alternative electrode combination of the plurality of alternative electrode combinations is different than the initial electrode combination and is associated with a respective power consumption value lower than a power consumption value associated with the initial electrode combination; and
receiving, via a user interface, user input selecting one alternative electrode combination from any of the plurality of alternative electrode combinations for delivery of electrical stimulation therapy.

US Pat. No. 10,709,889

LOCALIZED ELECTROMAGNETIC FIELD CONTROL IN IMPLANTABLE BIOMEDICAL PROBES USING SMART POLYMERS

Palo Alto Research Center...

1. An implantable biomedical probe for generating an electromagnetic field, comprising:a substrate;
one or more metallic coils positioned above the substrate, wherein at least one metallic coil is coupled to an alternating current (AC) current source, and wherein the one or more metallic coils are configured to generate the electromagnetic field surrounding the implantable biomedical probe; and
a smart polymer layer positioned above the one or more metallic coils, wherein the smart polymer layer comprises at least one photo-switching magnetic material that changes magnetic susceptibility in response to optical stimuli, thereby facilitating adjustment of the electromagnetic field surrounding the implantable biomedical probe by applying the optical stimuli.

US Pat. No. 10,709,888

SYSTEMS AND METHODS FOR MAKING AND USING AN ELECTRICAL STIMULATION SYSTEM FOR PERIPHERAL NERVE STIMULATION

BOSTON SCIENTIFIC NEUROMO...

1. An electrical stimulation lead, comprising:a lead body having a proximal end portion and a distal end portion, wherein the distal end portion has a smaller lateral width in at least one direction than a remainder of the lead body;
a plurality of terminals disposed at the proximal end portion of the lead body;
a plurality of electrodes disposed at the distal end portion of the lead body; and
a plurality of conductors extending along the lead body and electrically coupling the plurality of terminals to the plurality of electrodes.

US Pat. No. 10,709,887

DEVICES FOR DELIVERING NON-INVASIVE NEUROMODULATION TO A PATIENT

Helius Medical, Inc, New...

1. A method of placing a mouthpiece in a patient's mouth prior to engaging in a non-invasive neuromodulation therapy session, the method comprising:providing a mouthpiece to the patient, the mouthpiece comprising:
an elongated housing having an anterior region and a posterior region, and a non-planar exterior top surface;
a positioning pad having an anterior and a posterior region, the positioning pad attached to the top surface of the elongated housing; and
a first locator traversing a width of a transition region connecting a plateau of the anterior region of the elongated housing to a plateau of the posterior region of the elongated housing, the first locator integral with the top surface of the elongated housing;
placing the mouthpiece in the patient's mouth; and
manually adjusting the mouthpiece until the first locator is in contact with the patient's oral cavity.

US Pat. No. 10,709,886

ELECTRICAL STIMULATION LEADS AND SYSTEMS WITH ELONGATE ANCHORING ELEMENTS AND METHODS OF MAKING AND USING

BOSTON SCIENTIFIC NEUROMO...

1. An electrical stimulation lead, comprising:a lead body comprising a distal end portion, a proximal end portion, and a longitudinal length, wherein the lead body further comprises at least one anchoring lumen that extends longitudinally along at least a portion of the lead body, wherein the lead body further comprises at least one open slot that is spaced apart from each end of the lead body, wherein each of the at least one anchoring lumen is open at one of the at least one open slot and extends both distally and proximally from the one of the at least one open slot;
a plurality of electrodes disposed along the distal end portion of the lead body;
a plurality of terminals disposed along the proximal end portion of the lead body;
a plurality of conductors electrically coupling the terminals to the electrodes;
at least one anchoring element at least partially disposed in one of the at least one anchoring lumen, wherein each of the at least one anchoring element comprises at least one bent portion that is biased to extend an extension portion of the anchoring element out of one of the at least one slot when the anchoring element is in a deployed position and can retract the extension portion into the respective anchoring lumen when the anchoring element is in a constrained position; and
an attachment member attached to each of the at least one anchoring element, wherein the attachment member is disposed proximal to each of the at least one slot, wherein the attachment member is a band disposed along the lead body.

US Pat. No. 10,709,885

COMPOUNDING DEVICE, SYSTEM, KIT, SOFTWARE, AND METHOD

B. BRAUN MEDICAL INC., B...

1. A junction structure for use in a pharmaceutical compounding device, the compounding device having a housing that supports a pump system and a valving mechanism, the junction structure comprising:a junction body having a longitudinal axis and two lateral sides extending along either side of the longitudinal axis, the junction body further including a front side and a rear side each extending between the two lateral sides at opposite ends of the junction body;
a first inlet port located at one of two lateral sides of the junction body such that a first inlet conduit intersects the one of the two lateral sides of the junction body;
a second inlet port located at another of the two lateral sides of the junction body such that a second inlet conduit intersects the another of the two lateral sides of the junction body;
an outlet port located at a third portion of the junction body;
a mixing chamber located between the outlet port and both the first inlet port and second inlet port, the mixing chamber configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port; and
an attachment structure located on the junction body and configured to attach the junction structure to the housing of the compounding device, wherein
the outlet port is located at one of two lateral sides of the junction body such that the first inlet conduit extends from the first inlet port to the outlet port and intersects each of the two lateral sides of the junction body.

US Pat. No. 10,709,883

BANDAGE WITH MICRONEEDLES FOR ANTIMICROBIAL DELIVERY AND FLUID ABSORPTION FROM A WOUND

1. A bandage comprising:a film layer having a top surface and a bottom surface;
an adhesive applied to the bottom surface; and
an absorbent layer connected to the bottom surface,
a plurality of microneedles disposed within the absorbent layer, each microneedle of said plurality of microneedles having an end that extends through the absorbent layer and is configured to penetrate a wound when the bandage is applied over the wound;
an antimicrobial agent in communication with a fraction of a total quantity of said plurality of microneedles, so that upon application of the bandage to the wound, the antimicrobial agent is transported though said fraction of the total quantity of said plurality of microneedles to the wound,
wherein the remainder of the total quantity of said plurality of microneedles not in communication with the antimicrobial agent are configured to transport fluid from the wound to the absorbent layer.

US Pat. No. 10,709,882

THERAPEUTIC AGENT DELIVERY APPARATUS AND PROCESS

KENNETH ADAMS MEDICINE PR...

1. A device to deliver medication in a liquid formulation to a plurality of adjacent stationary tissue sites of a mammal, said device comprising:a) a plurality of tissue-engaging members for receiving said medication, wherein said plurality of tissue-engaging members are operably engageable with said plurality of adjacent stationary tissue sites;
b) a plurality of syringes containing said liquid formulation, and which syringes are separably connected to said plurality of tissue-engaging members through a plurality of flexible tubes or catheters which tubes or catheters are adapted to allow transfer of said liquid formulation from said syringes to said tissue-engaging members, wherein said flexible tubes or catheters allow the placement, angulation and depth of each of said tissue-engaging members to be individually controlled, and wherein each tissue-engaging member having an associated syringe so that the flow rate through each tissue-engaging member is separately controlled by the respective syringe; and
c) a single activatable plunger which is configured to engage plungers of said plurality of syringes, and when activated, supplies each of said plurality of tissue-engaging members with said liquid formulation from said syringes, at a controlled or uniform rate;
and thereby control the placement, amount and rate of medication simultaneously delivered to each of said plurality of tissue-engaging members.

US Pat. No. 10,709,881

APPARATUS FOR ADMINISTERING SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS

AcelRx Pharmaceuticals, I...

1. A drug delivery apparatus, comprising:a dispensing mechanism including a hub rotatable in a first direction and a second direction; and
a push rod at least partially disposed within a delivery passage of the drug delivery apparatus, the push rod being coupled to the hub of the dispensing mechanism, the push rod having a stopped position in which a surface of the push rod is positioned to prevent movement of a drug-containing tablet into the delivery passage, the dispensing mechanism being configured to move the push rod within the delivery passage when the hub is rotated in the first direction to dispense the drug-containing tablet from the drug delivery apparatus, the dispensing mechanism configured to move the push rod within the delivery passage to the stopped position when the hub is rotated in the second direction after the drug-containing tablet is dispensed from the drug delivery apparatus.

US Pat. No. 10,709,879

CEREBROSPINAL-FLUID SHUNT VALVE SYSTEM

Wisconsin Alumni Research...

1. A cerebral shunt used to treat an abnormal accumulation of cerebrospinal fluid (CSF) in a brain of a patient, comprising:a catheter adapted for implantation within the brain of the patient with a proximal portion within the brain opposite a distal portion diverting CSF out of the brain to another region of the patient;
a pressure sensor adapted for implantation within the brain of the patient and to produce a signal representing an intracranial pressure;
a valve connected to the catheter to conduct excess CSF to drain out of the brain through the catheter in an open position and to prevent the excess CSF from passing out of the brain through the catheter in a closed position; and
a valve driver control circuit communicating with the pressure sensor and the valve and operating to receive the signal representing the intracranial pressure and to control the valve to switch the valve between the open position and closed position in a cycle for successive cycles according to the signal representing the intracranial pressure and providing a measure of intracranial pressure so that the valve is opened at a first time when the measure of intracranial pressure is above a threshold value and the valve is closed at a second time following the first time while the measure of intracranial pressure still remains above the threshold value and to repeat an opening and closing of the valve while the measure of intracranial pressure remains above the threshold value;
wherein the valve comprises a piezo bender actuator receiving electrical signals from the valve controller to be electrically actuated to reposition the piezo bender actuator to open or close the valve; and
wherein the piezo bender actuator is a cantilever repositionable to change a position of a collar extending around a tube having an orifice in series with the catheter to block the orifice.

US Pat. No. 10,709,877

MEDICAL BALLOON WITH REINFORCING MEMBER

BOSTON SCIENTIFIC SCIMED,...

1. A catheter assembly, comprising:a catheter shaft;
a balloon attached to the catheter shaft, the balloon including a body and a proximal waist portion, the proximal waist portion having a proximal end;
a fiber braid including one or more individual filaments disposed along the balloon, the fiber braid having a proximal end aligned with the proximal end of the waist portion; and
a polymer sleeve disposed on the catheter shaft, wherein the polymer sleeve abuts the proximal end of the balloon waist and the proximal end of the braid such that an outer diameter of the catheter assembly remains substantially constant along the proximal waist portion of the balloon and an entirety of the polymer sleeve.

US Pat. No. 10,709,876

BALLOON CATHETER

ABBOTT CARDIOVASCULAR SYS...

1. A catheter comprising:an outer shaft member having a proximal section and a distal outer member, the outer shaft member having an inflation lumen defined therethrough;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft, a proximal cone portion, a working length, a distal cone portion, and a distal balloon shaft, wherein the proximal balloon shaft is coupled to the distal outer member; and
an inner tubular member comprising a plurality of tubes connected together and having guidewire lumen defined therethrough, the inner tubular member extending from the outer shaft member proximal section through the distal outer member and through the balloon to form a tip,
wherein the distal balloon shaft has an inner diameter and comprises a distal seal portion coupled to the inner tubular member and a proximal portion free of attachment to the inner tubular member and monolithic with the distal seal portion, and wherein the inner diameter is constant across the proximal portion of the distal balloon shaft and the distal seal portion, and the length of the proximal portion of the distal balloon shaft is at least two times the inner diameter of the distal balloon shaft.

US Pat. No. 10,709,875

INTRODUCER SHEATH

ABIOMED EUROPE GMBH, Aac...

1. An introducer sheath for providing access in a patient's body, comprising:a tubular body with a distal portion and a proximal portion, the proximal portion being configured to be inserted into the patient's body to allow a medical device to be inserted through the introducer sheath into the patient's body, the introducer sheath being structured to facilitate complete separation along its length in a longitudinal direction to allow removal from the medical device, the medical device extending through the tubular body of the introducer sheath; and
at least one handle which is pivotably attached to the distal portion of the tubular body via a hinge so as to be pivotable about a fulcrum, a first handle of the at least one handle having a first end portion and a free second end portion so as to form a lever, such that pivoting the first handle about the fulcrum causes a contacting portion of the first handle to act on a respective counter portion that is operatively connected to the distal portion of the tubular body, thereby creating a breaking force that causes the distal portion of the tubular body to break, and, thereby, allowing the introducer sheath to be separated along its length such that the introducer sheath can be removed from the medical device.

US Pat. No. 10,709,874

SYSTEM FOR ANCHORING MEDICAL DEVICES

INTERRAD Medical, Inc., ...

1. An anchor device for securing the position of a medical device, comprising:an external retainer assembly comprising a base, a cap configured to releasably couple with the base, and a gripping channel configured to engage an exterior surface of a medical device; and
first and second anchors that extend distally from a distal end of the external retainer assembly, each anchor comprising a flexible tine that is deployable in a subcutaneous region to secure the external retainer assembly relative to a skin penetration point;
wherein the external retainer assembly defines a longitudinal axis extending from a proximal end to a distal end, and the gripping channel has a non-circular cross-sectional shape in a plane generally perpendicular to the longitudinal axis, the non-circular cross-sectional shape defined in part by flat channel walls of the base and in part by flat channel walls of the cap and the cap has an outer peripheral shape that is non-symmetrical about the longitudinal axis.

US Pat. No. 10,709,873

DEVICE FOR HOLDING A CATHETER IN PLACE

1. A medical device configured for holding a catheter comprising:a body having
a conical portion having an apex, a base, a length extending between the apex and the base, a first end, a second end, and an inside surface,
a first adhesive on the inside surface of the conical portion adjacent to the first end of the conical portion,
a hollow cylindrical portion having an outer end, a second end which is unitary with the apex of the conical portion, a length which extends between the outer end and the second end of the cylindrical portion, an inside surface, and a hollow bore which extends from the outer end to the second end of the cylindrical portion, the inside surface of the cylindrical portion having an inner diameter,
a pull tab having a first portion mounted on the inside surface of the cylindrical portion adjacent to the outer end of the cylindrical portion, the pull tab further having a pull portion located outside the hollow bore;
a second adhesive releasably mounting the pull tab to the inside surface of the cylindrical portion, the second adhesive being spaced apart from the first adhesive on the conical portion so that the inside surface of the conical portion is free of adhesive between the adhesive adjacent to the first end of the conical portion and the cylindrical portion, the second adhesive including first and second portions, the second adhesive first portion being secured to the pull tab and the second adhesive second portion being located on the inside surface of the bore of the hollow cylindrical portion, the second adhesive first portion having adhesive properties selected so that the at least a portion of the second adhesive second portion remains in place on the inside surface of the cylindrical portion when the pull tab is separated from the cylindrical portion;
a catheter having an outside surface having an outer diameter,
the inside diameter of the hollow bore of the cylindrical portion being larger than the outer diameter of the catheter so that a gap is defined between the outside surface of the catheter and the inside surface of the cylindrical portion when the catheter is first inserted through the hollow bore;
the second adhesive second portion remaining on the inside surface of the cylindrical portion of the body having adhesive properties to releasably secure the cylindrical portion to the outside surface of the catheter when the catheter is in abutting contact with the inside surface of the cylindrical portion of the body.

US Pat. No. 10,709,872

REENTRY CATHETER AND METHOD THEREOF

THE SPECTRANETICS CORPORA...

1. A rapid exchange catheter system, comprising:a shaft having an inner lumen, an exchange port lumen and an exchange port fluidly coupled with the exchange port lumen, the exchange port arranged on a distal portion of the shaft, the inner lumen configured to receive a first wire, and the exchange port lumen and the exchange port configured to receive a wire; and
a rigid shroud coupled to the distal portion of the shaft, the rigid shroud comprising a first lumen, a second lumen, and a lateral port fluidly coupled with the second lumen of the shroud and the inner lumen of the shaft, the second lumen and the lateral port configured to receive the first wire, the first lumen comprising a proximal port and a distal port in the rigid shroud, wherein the exchange port is disposed proximally of the lateral port and the proximal port is disposed distally of the lateral port;
wherein, as viewed from a distal end view of the rapid exchange catheter system, the exchange port is disposed radially exterior of the rigid shroud.

US Pat. No. 10,709,871

CATHETER HAVING A STEERABLE TIP

Strategic Polymer Science...

1. A catheter assembly comprising:an elongated catheter shaft having a proximal end, a distal end, and an intermediate region between the distal end and the proximal end;
a control circuit coupled to a power source at the proximal end of the elongated catheter shaft, wherein the control circuit is configured to control one or more electrical control signals from the power source; and
a steerable tip coupled to the distal end of the elongated catheter shaft, the steerable tip having one or more electromechanical polymer (EMP) actuators embedded therein, the one or more EMP actuators configured to cause the steerable tip to deform in response to the one or more electrical control signals, wherein at least one of the one or more EMP actuators acts as both an actuator and a sensor that detects environment conditions surrounding the steerable tip and provides sensor signals to the control circuit indicative of the environment conditions, wherein the control circuit adjusts the one or more electrical control signals in response to the sensor signals, and wherein the power source is configured to provide the one or more electrical control signals to one or more of the EMP actuators.

US Pat. No. 10,709,870

STEERABLE MEDICAL DEVICE AND METHOD

Greatbatch Ltd., Clarenc...

1. A steerable medical device comprising:a handle including a longitudinal axis;
an elongate shaft extending distally from the handle, the elongate shaft including a distal tip and a lumen through the elongate shaft;
at least four pullwires disposed within the handle and extending to and anchored proximate the distal tip of the elongate shaft, the at least four pullwires including a first pullwire, a second pullwire, a third pullwire, and a fourth pullwire;
at least two actuators associated with the handle, the at least two actuators including a first actuator and a second actuator, the first actuator being operably coupled to the first and second pullwires and the second actuator being operably coupled to the third and fourth pullwires, wherein:
actuation of the first actuator in a first actuator direction causes tension in the first pullwire and deflection of the distal tip in a first tip direction;
actuation of the first actuator in a second actuator direction causes tension in the second pullwire and deflection of the distal tip in a second tip direction substantially opposite the first tip direction;
actuation of the second actuator in the first actuator direction causes tension in the third pullwire and deflection of the distal tip in a third tip direction different from the first tip direction and the second tip direction; and
actuation of the second actuator in the second actuator direction causes tension in the fourth pullwire and deflection of the distal tip in a fourth tip direction substantially opposite the third tip directions;
a first threaded member disposed within the handle and movable with the actuation of the first actuator in either the first actuator direction or the second actuator direction, the first threaded member being operably coupled to the first and second pullwires, wherein movement of the first threaded member causes the tension in at least one of the first pullwire and the second pullwire; and
a second threaded member disposed within the handle and movable with the actuation of the second actuator in either the first actuator direction or the second actuator direction, the second threaded member being operably coupled to the third and fourth pullwires, wherein movement of the second threaded member causes the tension in at least one of the third pullwire and the fourth pullwire; wherein the first threaded member at least partially overlaps the second threaded member, the second threaded member being disposed at least partially within the first threaded member, the first and second threaded members being independently actuatable with respect to one another.

US Pat. No. 10,709,869

RECIRCULATION MINIMIZING CATHETER

1. A recirculation minimizing catheter comprising:an elongated body portion having a longitudinal axis, a proximal end and a distal end;
the distal end comprising a first distal tip segment and a second distal tip segment that are split at a dividing point;
the first distal tip segment having a first lumen, a first distal tip, a straight tip with a side hole and a first distal tip opening;
the second distal tip segment having a second lumen, a second distal tip and a second distal tip opening, wherein the second distal tip segment is configured to have a J-shape with respect to the first distal tip segment;
the first distal tip segment having a concave shape with respect to the longitudinal axis, having a diameter of curvature that is larger than a diameter of curvature of the second distal tip segment, the first distal tip segment and the second distal tip segment each have a contact point that is configured to engage a blood vessel wall, and the first distal tip opening and the second distal tip opening have a distance between the two distal tip openings with a length more than 30 mm; and
wherein the recirculation minimizing catheter is configured such that the first distal tip segment after insertion inside a blood vessel bends outwardly and pushes the blood vessel wall outwardly to facilitate the bend backwardly of the second distal segment to form the j-shape to face a blood direction in the blood vessel.

US Pat. No. 10,709,868

CURVED SPLIT-TIP CATHETER

1. A hemodialysis curved split-tip catheter comprising:an elongated body portion having a longitudinal axis, a proximal end and a distal end;
the distal end comprising a first distal tip segment having a first lumen, a tip, and a first distal tip opening;
a second distal tip segment having a second lumen, a sealed portion having a contact point for engaging a blood vessel wall and a side opening, wherein the side hole of the second distal tip segment is located on a wall of the second lumen that faces the first distal tip segment;
the first distal tip segment having an angle with respect to a first axis extended from a dividing point longitudinally parallel to a blood vessel's centerline axis;
the second distal tip segment having a different angle with respect to the first axis to make the hemodialysis curved split-tip catheter in a non-centric configuration inside the blood vessel;
the first distal tip segment having a longer length with respect to the second distal tip segment;
the sealed portion of the second distal tip segment starts from the side opening till a tip of the second distal tip segment; and
wherein the hemodialysis curved split-tip catheter is configured to minimize fibrin sheath formation around the first distal opening and side opening.

US Pat. No. 10,709,867

GAZE-CONTINGENT MUSIC REWARD THERAPY

RAMOT AT TEL-AVIV UNIVERS...

1. A computerized method for treating a psychopathological condition, the method comprising using at least one hardware processor for:presenting, using an audio playback device, at least audio media to a patient;
receiving, from an eye tracker, a gaze direction of at least one eye of the patient;
computing a difference angle between a target direction and the gaze direction; and
pausing the audio media for a period of time, based, at least in part, on said computing,
wherein subsequent to the pausing, the audio media is at least in part rewound.

US Pat. No. 10,709,866

USABILITY FEATURES FOR RESPIRATORY HUMIDIFICATION SYSTEM

1. A port cap for use with a humidification chamber, the port cap comprising:a first portion configured to cover an inlet port of the humidification chamber for shipping and/or storage; and
a monolithic leg extending from the first portion to a distal end and configured to extend through the inlet port into the humidification chamber, the leg comprising a float contacting structure configured to contact one or more floats in the humidification chamber and restrain the one or more floats for shipping and/or storage, the leg comprising a stepped portion such that the leg transitions from a first width to a second width, wherein the float contacting structure comprises the stepped portion.

US Pat. No. 10,709,865

APPARATUS FOR MEASURING PROPERTIES OF GASES SUPPLIED TO A PATIENT

1. A respiratory therapy system configured to provide respiratory gases to a patient to treat one or more respiratory conditions of the patient, the respiratory therapy system comprising:a gases supply providing a flow of respiratory gases;
a gases outlet, the gases supply providing the flow of respiratory gases to the gases outlet, the gases outlet further comprising electrical connections configured to provide power to and receive the measurement signal from a heated delivery conduit;
at least one delivery conduit configured to convey said gases to the patient, the at least one delivery conduit comprising:
a heater wire configured to heat the gases flowing through the at least one delivery conduit; and
at least one temperature measurement circuit configured to measure the temperature of the gases flowing through the conduit and provide the measurement signal;
wherein the at least one delivery conduit is further configured to removably connect to the gases outlet and receive power from the gases outlet and provide the measurement signal to the gases outlet;
wherein the heater wire and the at least one temperature measurement circuit share at least one common electrical connection between the at least one delivery conduit and the gases outlet.

US Pat. No. 10,709,864

METHODS, SYSTEMS AND DEVICES FOR NON-INVASIVE OPEN VENTILATION WITH GAS DELIVERY NOZZLES WITH AN OUTER TUBE

Breathe Technologies, Inc...

1. A method of providing respiratory support, the method comprising:providing a non-invasive ventilation system comprising:
a ventilator;
a gas delivery circuit;
an outer tube having an open proximal end that is open to ambient air;
at least one jet nozzle disposed upstream of and outside the outer tube such that ventilation gas supplied to the at least one jet nozzle enters the outer tube through the open proximal end and entrained ambient air flows into the open proximal end around the periphery of the at least one jet nozzle;
at least one sensor; and
at least one nasal cushion at a distal end of the outer tube for impinging a nostril;
measuring spontaneous respiration with the at least one sensor; and
activating the ventilator to supply the ventilation gas in synchrony with phases of breathing through the gas delivery circuit and to the at least one jet nozzle such that the ventilation gas entrains ambient air at the open proximal end of the outer tube.

US Pat. No. 10,709,863

PATIENT CIRCUIT WITH ADJUSTABLE LENGTH

Koninklijke Philips N.V.,...

1. An interconnect assembly for a pressure support system, the pressure support system comprising a gas flow generator and a patient interface device fluidly coupled to the gas flow generator, the gas flow generator being structured to produce a flow of breathing gas for a patient, the interconnect assembly comprising:a conduit having a first end structured to be coupled to the gas flow generator and a second end structured to be coupled to the patient interface device, the conduit having a length; and
an adjustment assembly comprising:
a number of tension members each at least partially overlaying the conduit and being coupled to each of the first end and the second end, each of the tension members being structured to move independently with respect to the conduit, and
a winding apparatus connected to each of the tension members, the winding apparatus being structured to wind each of the tension members, wherein, when the winding apparatus winds the tension members, the length of the conduit decreases, and wherein the winding apparatus comprises a lumen for receiving breathing gas produced by the gas flow generator.

US Pat. No. 10,709,862

DEVICE FOR WITHDRAWING AND FOR TRANSPORTING A BREATHING GAS STREAM

1. A device for withdrawing a breathing gas stream from a ventilation system and for transporting the breathing gas stream to a gas analysis system, the device comprising:an upstream tube section comprising a gas-tight and moisture-permeable material defining a gas passage for the breathing gas stream and forming an upstream drying stage with an inner side and with an outer side and configured such that moisture is transported from the inner side of the upstream drying stage through the gas-tight and moisture-permeable material of the upstream drying stage to the outer side of the upstream tube section;
a downstream tube section comprising a gas-tight and moisture-permeable material defining a gas passage for the breathing gas stream and forming a downstream drying stage with an inner side and with an outer side and configured such that moisture is transported from the inner side of the downstream drying stage through the gas-tight and moisture-permeable material of the downstream drying stage to the outer side of the downstream tube section; and
at least one liquid storage device disposed downstream of the upstream drying stage and disposed upstream of the downstream drying stage and in fluid communication with the breathing gas stream for absorbing moisture from the breathing gas stream and storing absorbed moisture at the liquid storage and for releasing stored moisture from the liquid storage back into the breathing gas stream, wherein the breathing gas stream passes through the device in the sequence of the upstream drying stage of the first tube section, followed by the liquid storage device and then followed by the downstream drying stage of the second tube section, wherein the upstream tube section, the downstream tube section and the at least one liquid storage device together form a tubular configuration.

US Pat. No. 10,709,861

NASAL CANNULA WITH FLOW RESTRICTOR

1. A nasal cannula, comprising:a central body portion defining a cavity and comprising two prongs extending from the central body portion, the central body portion also comprising an inlet,
wherein at least one localized reduction in cross-sectional area is positioned on a manifold, wherein the manifold positions the at least one localized reduction in cross-sectional area in a space of the cavity between the two prongs when the manifold is received within the central body portion, wherein the manifold is adapted to receive gases from a gas source,
wherein the at least one localized reduction in cross-sectional area is configured to lower a gas flow rate of gases downstream of the at least one localized reduction in cross-sectional area, wherein the at least one localized reduction is adjustable in position along a longitudinal axis of the cavity of the central body portion.

US Pat. No. 10,709,860

PATIENT INTERFACE WITH AN ADJUSTABLE CUSHION

RIC Investments LLC, Wil...

1. A patient interface comprising:a faceplate including a plurality of headgear attachment elements, the faceplate having a seal support portion, a forehead support portion and an arm connecting the seal support portion with the forehead support portion;
a seal member directly coupled to and extending directly from the seal support portion of the faceplate;
a seal support member directly connected to the seal member, the seal support member being separate and distinct from the faceplate; and
an adjustment mechanism directly connected to the seal support member and extending between the seal support member and the arm of the faceplate and coupling the seal member to the arm of the faceplate, wherein the adjustment mechanism is structured to enable movement of the seal support member relative to the faceplate such that the seal member is adjustable relative to the faceplate from a first position to a second position and structured to maintain the seal member in the second position during use of the patient interface, wherein the adjustment mechanism comprises a linkage having a first portion operatively coupled to the seal member through the seal support member and a second portion directly coupled to the arm of the faceplate, and wherein the second portion is moveable along a portion of a length of the arm of the faceplate to alter an effective length of the linkage.

US Pat. No. 10,709,859

PATIENT GAS DELIVERY MASK WITH IMPROVED GAS FLOW DISRUPTER

SOUTHMEDIC INCORPORATED, ...

1. A mask for administering a breathable gas to a patient, the mask comprising a mask body and a gas flow disrupter joined to the mask body, the mask body configured to position the flow disrupter in a position spaced from and opposing the patient's nose and mouth region when worn by the patient, and a gas inlet within the mask body for discharging gas from a source into an interior of the mask body through the flow disrupter, the flow disrupter comprising:a peripheral wall that defines an interior space within the periphery of the wall, the wall having an inside surface facing the interior space and an outside surface;
a baffle structure located within the interior space, the baffle structure comprising a baffle member configured to block a portion of the interior space within the flow disrupter, the baffle structure further comprising at least one gas turbulence generator consisting of one or more of a rib, a fin, a dimple, a protuberance;
at least one gap between the baffle member and the inside surface of the peripheral wall for gas flow through the flow disrupter.

US Pat. No. 10,709,858

SEALING MECHANISM FOR ANAESTHETIC AIRWAY DEVICES

AIRWAY MEDICAL LIMITED, ...

26. A multipurpose oropharyngeal airway device adapted for insertion into a mouth of a patient, said airway device comprising:(a) an elongate, tubular airway body of substantially elliptical or substantially circular cross-section, the tubular airway body having:
a substantially straight section, and a proximal end which is adapted to function as an integral bite block;
a curved distal section that is configured to substantially conform to the curvature of a part of the patient's pharynx between the soft palate and an upper edge of the epiglottis, the curved distal section having a distal tip with a tear-drop shaped downwardly offset rim that aids placement of the airway device into the mouth of the patient and spreads pressure across a back of a tongue; and
a central channel for passage of oxygen and anaesthetic gasses and for accepting an intubation device and for accepting an endoscopic device;
(b) a substantially oval-shaped detachable intraoral self retaining and self sealing plate for dynamically sealing the mouth from inside the mouth having a central aperture for receiving the tubular airway body; and
(c) a connector for facilitating attachment of breathing or anaesthesia equipment thereto, wherein the connector is attached to the proximal end of the tubular airway body and has a groove on its external surface, wherein the groove forms a circular channel for accepting the detachable intraoral plate;
wherein the plate which is essentially flat with a reinforced rim around the perimeter resists deformation with a second rim surrounding the central aperture,
wherein the plate is a one piece construction of polyvinyl chloride, polyurethane, silicone or some other elastomeric material possessing properties of elasticity, resilience and flexibility, so that the plate is self retaining and self sealing, which elasticity allows the plate to be fitted and retained in position on airway devices and allows the plate to be compressed between thumb and forefinger for placement inside the cheeks of the patient, and when released by the thumb and forefinger to be compressed by the cheeks and forced to follow a curved contour of the inside of the cheeks and dynamically seal the mouth from the inside and a sealing effect is enhanced during positive pressure ventilation by a gas pressure pushing the plate against the inside of the mouth;
wherein between the reinforced rim around the perimeter of the plate and the second rim surrounding the central aperture, the plate is soft and flexible, wherein the plate is configured to seal the mouth opening by adhering to a soft moist and smooth inner mucosa of the cheeks and lips;
wherein the plate does not seal a large opening between the upper and lower jaws but rather seals the mouth of the patient due to the width of the vestibule of the mouth being much greater than the width of the mouth opening and allowing for the width of the plate to be much greater than the maximum width of the mouth opening, whereby the corners of the mouth retain the multipurpose airway device and are sealed and no gas leaks from the corners of the mouth, whereby the multipurpose oropharyngeal airway body is self retaining, self sealing and hands free.

US Pat. No. 10,709,857

MANUAL VENTILATION METHOD AND SYSTEM

General Electric Company,...

1. A method of controlling fresh gas flow during manual ventilation by a clinician, the method comprising:measuring patient airway pressure (Paw) of a patient throughout a compression and release cycle of a breathing bag by the clinician, wherein the Paw is measured with a pressure sensor in a breathing circuit ventilating the patient;
determining a measured minimum Paw during a release stroke of the compression and release cycle;
determining a difference between the measured minimum Paw and a desired minimum Paw;
calculating a fresh gas flow rate of fresh gas into the breathing circuit based on the Paw and the difference between the measured minimum Paw and the desired minimum Paw; and
controlling a gas supply system to supply fresh gas at the fresh gas flow rate for at least a portion of the compression and release cycle.

US Pat. No. 10,709,856

OPERATING AND INFORMATION SYSTEM FOR A BREATHING APPARATUS

LOEWENSTEIN MEDICAL TECHN...

1. An operating and information system for a breathing apparatus, wherein the system comprises a display for displaying information and for displaying operating fields for a user and having at least one touch-sensitive input field in spatial proximity to a displayed operating field and whereina first operating field and a second operating field are displayed in a region of the display, and
a processing unit which is coupled to the display and to the touch-sensitive input unit is configured
to detect operation of the first operating field via the touch-sensitive input unit and, on the basis thereof, to cause a control unit to carry out or display a function assigned to the operating field, and wherein the control unit registers current or resistance or voltage changes in a region of interfaces or connections to a humidifier and thereby detects when a humidifier is adapted to a humidifier connection, and the control unit then displays a new menu with an operating field for the humidifier via the display.

US Pat. No. 10,709,855

APPARATUS AND METHOD FOR IMPROVED ASSISTED VENTILATION

CoLabs Medical, Inc., Mo...

1. A method of artificially ventilating an individual, the method comprising:inserting a working end of a ventilation device within a respiratory opening of the individual and positioning the working end of the ventilation device within a body passageway of the individual, where the working end includes a first opening fluidly coupled to a first lumen and a second opening fluidly coupled to a second lumen, where the second opening is located along the ventilation device proximal to the first opening, the ventilation device also having a pressure sensor configured to detect pressure changes within the body passageway where the ventilation device is configured for an automatic delivery of a bolus of air into an airway of the individual at a pre-determined rate;
drawing suction through the first opening to induce collapse of the body passageway and maintaining the suction for a period of time;
delaying delivery of the bolus of air when the sensor detects a pressure change in the air within the body passageway, where the pressure change within the body passageway results from a chest compression; and
delivering the bolus of air through the first lumen upon failure to detect collapse of the body passageway and delivering the bolus of air through the second lumen while maintaining the suction upon detecting collapse of the body passageway.

US Pat. No. 10,709,854

METHODS AND SYSTEMS FOR ADAPTIVE BASE FLOW AND LEAK COMPENSATION

Covidien LP, Mansfield, ...

1. A method for improving an accuracy of estimating an exhalation volume while ventilating a patient with a ventilator, the ventilator comprising at least one processor and at least one memory, the method comprising:delivering a base flow to a patient during exhalation, wherein the base flow includes an estimated leak flow;
determining, by the ventilator, an initial base flow;
determining, by the ventilator, an initial inspiratory trigger threshold;
delivering the initial base flow during at least a first portion of the exhalation while setting an inspiratory trigger threshold to the initial inspiratory trigger threshold;
changing the base flow from the initial base flow toward a subsequent base flow during at least a second portion of exhalation;
decreasing the inspiratory trigger threshold from the initial inspiratory trigger threshold toward a subsequent inspiratory trigger threshold while changing the base flow;
determining a change in the estimated leak flow;
progressively adjusting the base flow according to an exponential trajectory in a set time period during at least the second portion of exhalation to compensate for the determined change in the estimated leak flow; and
progressively adjusting the inspiratory trigger threshold in the set time period.

US Pat. No. 10,709,853

DEVICE

Intracair IVS, Odder (DK...

1. A device for sealing a tracheostoma in a patient, comprising a seal member for insertion through the tracheostoma to a trachea, wherein the seal member comprises a disc having a predetermined line of weakness, wherein in a first configuration the seal member forms a seal by being pulled against the tracheostoma, and wherein in a second configuration the seal member is removed from the trachea through the tracheostoma by breaking along the line of weakness.

US Pat. No. 10,709,852

DELIVERY DEVICE AND KIT, AND METHOD OF USE

Trudell Medical Internati...

1. A delivery device comprising:a substance dispenser;
a mask in fluid communication with said substance dispenser, said mask comprising a mounting portion comprising a hard plastic coupled to a sealing portion comprising a soft polymer, said sealing portion comprising a bottom flexible edge portion, and a pair of flexible side portions, said side portions extending upwardly from said bottom portion and connecting at an apex, wherein said mounting portion comprises a hinged arm, said arm moveable from an open position to a closed position, and further comprising a valve, said, valve moveable from a first position to a second position as said arm is moved from said open position to said closed position, wherein said valve covers an opening in said mounting portion when moved to said second position.

US Pat. No. 10,709,851

SYSTEMS, METHODS AND DEVICES FOR SUBCUTANEOUS TARGET LOCATION

SIENTRA, INC., Santa Bar...

1. An assembly, comprising:a base including a first infusion port and a target magnet housing;
a target magnet disposed in the target magnet housing, the target magnet including a magnetic pole proximal a first side of the target magnet housing and a magnetically opposite pole proximal a second side of the target magnet housing, wherein the target magnet is separated and spaced from the first infusion port;
a locator assembly including a locator base and a locator housing, the locator base including a first port aperture proximal a first side of the locator base and a second port aperture proximal a second side of the locator base; and
at least two locator magnets respectively disposed at least partially within the locator housing proximal respective sides of the locator housing, the two locator magnets being separated and spaced from the first and second port apertures.

US Pat. No. 10,709,850

SYRINGE ADAPTER FOR MEDICATION

1. A method of administering viscous fluid medication, comprising:affixing a syringe adapter to a syringe, the syringe adapter comprising a sidewall extending between a proximal end and a distal end opposite the proximal end and a support hub member radially surrounding at least a portion of a length of the proximal end of the sidewall, the sidewall having an interior surface defining a chamber, a first opening at the distal end being defined by a first terminal end of the sidewall and a second opening at the proximal end being defined by a second terminal end of the sidewall, wherein the affixing further comprises:
slipping a proximal end of the support hub member over an exterior of a syringe tip located at a distal end of a syringe, the syringe tip having a third opening in a protrusion extending distally therefrom; and
connecting the proximal end of the sidewall to an internal threaded portion of the syringe tip;
inserting the distal end of the of the sidewall into a container of viscous fluid medication;
withdrawing, from the container, at least a portion of the viscous fluid medication through the first opening and into the chamber, and from the chamber through the second opening and the third opening and into a barrel of the syringe, wherein the first opening has an inner diameter of at least about 0.05 inches, the inner diameter sized to facilitate the withdrawing of the viscous fluid medication;
subsequent to the withdrawing from the container and while the proximal end of the sidewall of the syringe adapter remains connected to the syringe tip of the syringe, affixing a proximal end of a needle holder to a distal end of the support hub member, a distal end of the needle holder having affixed thereto a proximal end of a needle and in absence of the needle on the needle holder, subsequently affixing the needle thereto; and
injecting, into a recipient with the needle affixed to the needle holder while the proximal end of the sidewall of the syringe adapter remains connected to the syringe tip of the syringe and while the proximal end of the needle holder remains connected to the distal end of the support hub member, at least a portion of the viscous fluid medication withdrawn into the barrel.

US Pat. No. 10,709,849

GUIDE FOR AN INJECTION DEVICE

Cilag GmbH International,...

1. A guide for contacting an injection device with a user, the guide comprising:a first component including a first end adapted to engage a housing of the injection device, the first component including at least one ratchet tooth;
a second component including a second end adapted to engage a surface of the user's skin, wherein the second component is movable with respect to the first component, and wherein the second component comprises an inner surface including a plurality of ratchet teeth disposed in series that engage the at least one ratchet tooth on the first component such that the housing moves towards the user's skin incrementally.

US Pat. No. 10,709,848

SEGMENTED SAFETY COVER FOR NEEDLE DELIVERY

1. A segmented safety cover comprising: a) a proximal segment combined with a needle hub; b) a needle cannula that extends from the proximal needle hub to a distal sharpened end; c) a distal end cap with a hollow bore through which the needle cannula passes; d) a centrally mounted toggle locking mechanism, separating the proximal needle hub from the distal end cap, hingedly connected to both and maintaining the segmented safety cover in a position where it completely covers a needle tip on a needle; e) wherein the toggle locking mechanism is resistively bias-assisted and comprises a proximal cover segment and a distal cover segment which overlay the needle cannula and is linked together through a central hinge; f) said proximal cover segment and said distal cover segment of said toggle locking mechanism being configured with abutting faces that contact each other above said central hinge when the segmented safety cover is in a safety mode; g) wherein the proximal cover segment is connected to the hub via a proximal hinge and the distal cover segment is connected to the end cap via a distal hinge; and h) wherein the proximal hinge, abutting faces and distal hinge are in line and the central hinge is below the abutting faces in the safety mode so that a force exerted on the distal end cap is translated onto the abutting faces above the central hinge thereby maintaining the device in a secured state wherein the segmented safety cover is in a position where it completely covers the needle tip, while maintaining the distal end cap's position covering the needle tip extending through the needle cannula.

US Pat. No. 10,709,847

RETRACTABLE NEEDLE SYRINGE WITH UNITARY PROPELLANT RELEASE MODULE

L.O.M. Laboratories Inc.,...

1. A modular retractable needle assembly for engagement with a barrel of a retractable needle syringe having a plunger, the modular retractable needle assembly comprising:a body having an upper chamber at a proximal end thereof;
a propellant chamber defined within the body, the propellant chamber having an inside wall and an outside wall provided by the body;
a seal sealingly engaged over an upper proximal edge of each of the inside wall and the outside wall of the propellant chamber to seal a propellant in the propellant chamber;
a retention member initially engaged within the upper chamber, the retention member being moveable in a distal direction in response to an application of a post-injection force to the plunger by a user;
a needle hub initially engaged within the retention member, the needle hub being engageable with a retractable locking tip of the plunger upon the application of the post-injection force to the plunger by the user;
a needle for injecting medicament into a patient engaged with the needle hub and projecting distally from the body; and
a rupturing member projecting in the distal direction, the rupturing member being moveable in the distal direction in response to the application of the post-injection force to the plunger by the user to rupture the seal and thereby release propellant into the upper chamber.

US Pat. No. 10,709,846

PEN NEEDLE ATTACHMENT MECHANISMS

Becton, Dickinson and Com...

1. A pen needle, comprising:a needle-bearing hub having threads for attachment to a medication delivery device and at least one circumferentially oriented flexible tab located proximally of the threads;
the needle-bearing hub having a radially outward surface including a step portion forming a locking surface on the needle-bearing hub perpendicular to an axis of a needle; and
an outer cover received over the needle-bearing hub having a closed distal end and an open proximal end, and a locking rib at the open proximal end projecting radially inwardly and abutting the locking surface on the needle-bearing hub; wherein
the at least one circumferentially oriented flexible tab having a radially outward projection positioned at one end of the step portion on the needle-bearing hub;
the locking rib engages the radially outward projection of the at least one circumferentially oriented flexible tab on the needle-bearing hub and causes the outer cover to rotate together with the needle-bearing hub when the needle-bearing hub is rotated for installation on the medication delivery device; and
when sufficient force develops between the outer cover and the needle-bearing hub during installation of the needle-bearing hub on the medication delivery device, the locking rib rides over the radially outward projection on the at least one circumferentially oriented flexible tab on the needle-bearing hub where it is freed from the locking surface;
and further comprising two opposed sloping surfaces converging toward a channel at one end of the step portion on the needle-bearing hub, the locking rib on the outer cover being inserted into the channel to install the outer cover over the needle-bearing hub.

US Pat. No. 10,709,845

DRUG DELIVERY DEVICE WITH A ROTATABLE DRIVE MECHANISM

AMGEN INC., Thousand Oak...

1. A rotatable drive mechanism for a drug delivery device, the drive mechanism comprising:a lead screw having a distal end, a proximal end, and external threads;
a bearing operably attached to the proximal end of the lead screw;
a ball screw driver having a threaded aperture, wherein the threaded aperture is configured to rotatably engage with the external threads of the lead screw, the ball screw driver and lead screw being coaxially aligned;
a biasing device disposed between the bearing and the ball screw driver generating an axial drive force for biasing the ball screw driver away from the bearing; and
an activation device configured to release the biasing device and allow the biasing device to expand from a compressed position to an extended position through which the axial drive force of the biasing device causes the ball screw driver to axially move toward the distal end of the lead screw and rotate the lead screw such that a threaded engagement between the lead screw and the ball screw driver bears the axial drive force.

US Pat. No. 10,709,844

INJECTOR SAFETY DEVICE

Antares Pharma, Inc., Ew...

1. An injector, comprising:a housing;
a container portion disposed within the housing, defining a fluid chamber containing a medicament, and including a plunger moveably disposed therein and defining a portion of the fluid chamber;
a firing mechanism including a ram;
a latch moveably disposed within the housing and configured to engage a portion of the ram;
a trigger moveably disposed within the housing between a ready position wherein the latch is held in engagement with the portion of the ram and a firing position wherein the latch is released, permitting movement of the ram;
a safety member that is positionable relative to the housing so as to restrict movement of the trigger into the firing position; and
a guard moveable with respect to the housing from a protecting position to an actuating position, wherein movement of the guard to the actuating position moves the trigger into the firing position, wherein the safety member prevents movement of the guard into the actuating position,
wherein the housing includes an opening formed therein, and wherein the safety member includes a blocking member having an end disposed within the housing so as to abut a portion of the trigger, the blocking member extending through the opening of the housing and attaching to a body portion of the safety member that is disposed outside of the housing.

US Pat. No. 10,709,843

DEVICE AND METHOD FOR REPETITIVE NEEDLELESS INJECTION

KOLORPEN LTD., Afula (IL...

1. A device for repetitive needleless injection of a liquid into a surface, the device comprising:a handheld unit that includes at least a cell that is fillable with the liquid, and a propulsion mechanism configured to apply a sequence of pressure pulses to the liquid, each pulse of the sequence of pressure pulses to eject a micro-jet of the liquid from the cell via an orifice between the cell and an exterior of the handheld unit with a velocity that is sufficient to enable the micro-jet to penetrate into the surface;
a reservoir that is connected to the cell by a conduit to enable the liquid to flow from the reservoir to the cell to replace the liquid that is ejected in the micro-jet; and
a controller that is configured to operate the propulsion mechanism repeatedly so as to eject the sequence of the micro-jets,
wherein the propulsion mechanism comprises an impulse generator configured to displace an actuation surface to generate the pulse and a plunger configured to move linearly to transmit the pulse to the cell, and
wherein the impulse generator is configured to expand to compress a propulsion resilient element and to contract to enable expansion of the propulsion resilient element to distally propel the plunger.

US Pat. No. 10,709,842

DAMPERS AND METHODS FOR PERFORMING MEASUREMENTS IN AN AUTOINJECTOR

California Institute of T...

1. A method for measuring pressure and strain in an instrumented autoinjector, comprising:creating an autoinjector shell, the autoinjector shell being elongated and hollow for housing autoinjector components, including a syringe and a syringe carrier;
installing a pressure transducer inside the syringe;
filling the syringe with fluid;
installing at least one strain gauge on an outer surface of the syringe;
assembling an instrumented autoinjector by:
mounting the syringe with the pressure transducer, the fluid, and the at least one strain gauge into the syringe carrier; and
mounting the syringe carrier into the autoinjector shell;
activating the instrumented autoinjector;
measuring liquid pressure in the syringe by recording data transmitted from the pressure transducer; and
measuring hoop and axial strains on the outer surface of the syringe by recording data transmitted from the at least one strain gauge.

US Pat. No. 10,709,841

INJECTION DEVICE

Owen Mumford Limited, Ox...

1. An injection device for delivery of a medicament from a container through a needle disposed at a distal end of the container, the container having a stopper for containing the medicament within the container, the device comprising:a housing;
an advancing mechanism comprising a compression spring operable to move the container relative to the housing from a starting position in which the needle is shrouded and an insertion position in which the needle is exposed; and
a stopper drive arrangement operable to move the stopper towards the distal end of the container, the stopper drive arrangement comprising:
a drive body arranged for axial movement with respect to the housing;
a driveshaft arranged for rotation with respect to the drive body;
a plunger arranged for axial movement with respect to the drive body to move the stopper upon rotation of the driveshaft; and
a drive spring arranged to rotate the driveshaft upon activation of the stopper drive arrangement,
the drive spring being housed within the drive body.

US Pat. No. 10,709,839

PRECISION VARIABLE FLOW RATE INFUSION SYSTEM AND METHOD

Repro-Med Systems, Inc., ...

1. A precision variable flow rate infusion system for delivering a liquid driven by a constant pressure pump from a reservoir having an initial outflow rate to a known and adjustable flow rate less than the initial outflow rate for infusion to a patient, the liquid having a maximum dosage flow rate, comprising:a first flexible flow rate tubing having a known length from a proximal end to a distal end and a pre-defined flow rate generally established by a consistent internal diameter along the length to create a known flow rate for the liquid passing therethrough, the known flow rate not exceeding the maximum dosage flow rate for the liquid; and
an adjustable flow rate controller having an inlet and an outlet, at least one internal fluid pathway there between and a fluid pathway modifier structured and arranged to modify the at least one internal fluid pathway from the inlet to the outlet from a closed pathway to a maximum flow pathway with a plurality of different flow rate pathways there between providing from a maximum adjuster flow rate to a zero flow rate, a flow rate scale visually indicating variable flow rates from the maximum dosage flow rate to the zero flow rate, the adjustable flow rate controller inlet coupled to the first flexible flow rate tubing to receive the liquid at the known flow rate established by the first flexible flow rate tubing;
wherein the pre-defined flow rate and the maximum adjuster flow rate cooperatively combining to be equal to or less than the maximum dosage flow rate for the liquid from the reservoir;
wherein the combination of the pre-defined flow rate and the maximum adjuster flow rate determine a maximum delivery flow rate of liquid from the reservoir through the system, and the adjustable flow rate controller permitting precision flow rate control from an off flow rate to about the maximum delivery flow rate permitted by the combination of the pre-defined flow rate and the maximum adjuster flow;
wherein the variable flow rate infusion system is pre-calibrated with sterile gas correlated to an intended liquid to provide the flow rate scale tuned for each assembly of the first flexible flow rate tubing and the adjustable flow rate controller.

US Pat. No. 10,709,838

PUMPING FLUID DELIVERY SYSTEMS AND METHODS USING FORCE APPLICATION ASSEMBLY

DEKA Products Limited Par...

1. A wearable insulin pump assembly system for coupling to a reservoir that contains insulin, the wearable insulin pump assembly system comprising:a wearable insulin pump housing portion that contains a reservoir, a pump chamber, an outlet end on one side of the pump chamber and a receptacle on a second side of the pump chamber, the receptacle having a size and shape for receiving one end of the reservoir, the receptacle being in fluid flow communication with the pump chamber;
a rotary pump blade supported for rotation on the pump chamber, the rotary pump blade comprising a grouping of coupled projections;
a shape memory actuator configured to apply a rotating force to the grouping of coupled projections
a flow communicator located within the receptacle for providing a flow path for communication of the insulin from a reservoir to the pump chamber when one end of the reservoir is received within the receptacle; and
a pump housing septum on the outlet end of the pump housing portion for allowing a hollow needle to extend through the septum structure to provide a fluid flow path out from the outlet end of the pump housing portion;
wherein the rotary pump blade causes insulin to be urged from the pump chamber, and
wherein the wearable insulin pump is for delivering insulin from the reservoir to a user through the outlet end of the pump housing portion, further comprising a shape memory actuator configured to apply a rotating force to the grouping of coupled projections.

US Pat. No. 10,709,837

SPIKE CAP AND PRETREATMENT METHOD FOR INFUSION SET USING SAID SPIKE CAP

1. A spike cap, comprising:an opening for not allowing passage of solids or liquids but for allowing passage of gas from an interior of the cap,
a hydrophobic filter arranged at a location inward from an insertion port where a tip of a spike is inserted into the interior of the cap, said hydrophobic filter not allowing passage of solids or liquids to said opening but allowing passage of gas to said opening, whereby air passes through the hydrophobic filter and is discharged through the opening, and
a lid for closing said opening at an exterior of said opening.

US Pat. No. 10,709,836

NEEDLE SHIELDING ASSEMBLIES AND INFUSION DEVICES FOR USE THEREWITH

Becton, Dickinson and Com...

1. A needle assembly, comprising:a needle having a sharpened end and an opposing end, the needle being insertable through a base; and
a needle shield device, comprising:
a first shield having at least one cantilevered arm with a tapered edge;
a second shield having a stop; and
a biasing element biasing the first shield axially away from the second shield;
wherein one of the first and second shields is fixedly connected to the opposing end of the needle, and is connectable to one of the base and a fluid connector connectable to the base;
wherein in a first position of the second shield relative to the first shield, in which the sharpened end of the needle is exposed outside the second shield, the stop engages with the tapered edge of the first shield to create a jam connection with the one of the base and the fluid connector, the first and second shields having a common central axis;
wherein proximal displacement of the second shield relative to the one of the base and the fluid connector proximally displaces the first shield along with the second shield until the first shield is no longer connected to the one of the base and the fluid connector; and
wherein when the one of the first and second shields that is fixedly connected to the opposing end of the needle is no longer connected to the one of the base and the fluid connector, under the force of the spring, the cantilevered arm of the first shield deflects relative to the stop and the first shield displaces axially relative to the second shield to cover the sharpened end of the needle.

US Pat. No. 10,709,835

SYRINGE PUMP AND ARRAY OF SYRINGE PUMPS WITH MULTI-ZONE ELECTRONIC DISPLAY

1. A syringe pump comprising:a housing comprising an electronic display, a syringe retainer, and a plunger driver;
the syringe retainer being held in a fixed position relative to the electronic display by the housing to fixedly retain a substantial portion of a barrel of a syringe in a fixed position located adjacent to and superimposed over the electronic display such that, when the electronic display is activated, at least the substantial portion of the barrel of the syringe is illuminated by a backlight provided by the electronic display behind the substantial portion of the barrel; and
the electronic display comprising an array of pixels and operable to divide the electronic display into a first zone of the electronic display and a second zone of the electronic display spanning a length equivalent to at least the substantial portion of the barrel of the syringe when the syringe is retained by the syringe retainer and superimposed over the electronic display, wherein, when the electronic display is activated, the second zone is illuminated by the pixels with a different color than the first zone, and the barrel of the syringe, when the syringe is retained by the syringe retainer, is illuminated in the different color by the second zone of the electronic display behind the substantial portion of the barrel.

US Pat. No. 10,709,834

MEDICATION FLUID INFUSION SET COMPONENT WITH INTEGRATED PHYSIOLOGICAL ANALYTE SENSOR, AND CORRESPONDING FLUID INFUSION DEVICE

Medtronic MiniMed, Inc., ...

1. A medical device component for delivering medication fluid to a patient, the medical device component comprising:a body-mountable base unit comprising:
a base structure;
a lid assembly affixed and sealed to the base structure;
a body-insertable cannula that accommodates delivery of medication fluid to the patient, the cannula having an upstream end securely attached to the base structure and having a downstream end extending from the base structure;
a self-sealing septum coupled to the base structure to fluidly seal the upstream end of the cannula, wherein the self-sealing septum is maintained in position between the base structure and the lid assembly;
a body-insertable physiological analyte sensor secured to and extending from the base structure, the sensor facilitating measurement of a physiological characteristic of the patient, and the sensor comprising a plurality of sensor leads; and
an electronics assembly coupled to the base structure, the electronics assembly electrically connected to the sensor leads to obtain measurements of the physiological characteristic in an analog domain, and the electronics assembly comprising a digital processing circuit to convert measurements of the physiological characteristic from the analog domain into digital sensor data, to digitally process the digital sensor data into conditioned digital sensor data, and to communicate the conditioned digital sensor data to a fluid infusion device associated with the medical device component; and
a top cover assembly that is removably couplable to the body-mountable base unit such that the top cover assembly covers the lid assembly of the body-mountable base unit, the top cover assembly comprising:
a lid structure that releasably mates with the base structure, the lid structure comprising an interior space defined by an inner surface of the lid structure, and the lid structure comprising at least one structural support feature;
an infusion tube secured to the inner surface of the lid structure and terminating within the interior space, wherein the at least one structural support feature of the lid structure receives, secures, and retains a downstream end of the infusion tube;
a tubing connector fluidly coupled to the infusion tube, the tubing connector having a distal end supported by the at least one structural support feature of the lid structure, the distal end of the tubing connector penetrating the self-sealing septum to establish a fluid delivery flow path from inside the infusion tube, through the self-sealing septum, and into the cannula when the top cover assembly is coupled to the body-mountable base unit, wherein the self-sealing septum seals the upstream end of the cannula when the top cover assembly is removed from the body-mountable base unit and the tubing connector is withdrawn from the self-sealing septum;
a plurality of sensor conductors carried by or integrated with the infusion tube, the sensor conductors terminating within the interior space; and
an electrical interconnect assembly coupled to the inner surface of the lid structure, the electrical interconnect assembly establishing electrical connectivity between the sensor conductors and the electronics assembly when the top cover assembly is coupled to the body-mountable base unit, to facilitate communication of the conditioned digital sensor data from the electronics assembly to the fluid infusion device.

US Pat. No. 10,709,832

METHODS AND SYSTEMS FOR ESTABLISHING RETROGRADE CAROTID ARTERIAL BLOOD FLOW

Silk Road Medical, Inc., ...

1. A system for use in accessing and treating a target artery, said system comprising:an arterial access device adapted to be introduced into a common carotid artery and receive blood flow from the target artery;
a shunt fluidly connected to the arterial access device, wherein the shunt provides a pathway for blood to flow from the arterial access device to a return site; and
a flow control assembly coupled to the shunt and adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state, wherein the flow control assembly includes one or more components that interact with the blood flow through the shunt, wherein the flow control assembly comprises two or more parallel flow paths and a valve to open or close one or more of the flow paths to adjust the state of flow by selectively directing blood flow through one or more of the flow paths.

US Pat. No. 10,709,831

METHOD AND APPARATUS FOR PERFORMING PERITONEAL ULTRAFILTRATION

TRIOMED AB, Lund (SE)

1. An apparatus for ultrafiltration of a patient, which patient has a peritoneal fluid in a peritoneal cavity, comprising:a cassette having first, second, third and fourth ports;
a patient tube including a patient connector provided at one end of the patient tube and configured to be connected to a patient line for access to the peritoneal cavity of the patient, another end of said patient tube being configured for connection to said first port of the cassette, wherein the patient tube further includes a flow pump configured for removing and returning of a portion of said peritoneal fluid between the cassette and the peritoneal cavity using said patient tube;
an intermittent bag and an intermittent tube for connection of the intermittent bag to said second port of the cassette, wherein the intermittent tube includes an intermittent valve, whereby said intermittent bag and intermittent tube are configured to receive said portion of said peritoneal fluid being removed from the peritoneal cavity through said patient tube by said flow pump and return said portion of said peritoneal fluid to the peritoneal cavity using said patient tube by said flow pump;
a drain tube for connection of a drain bag to said third port of the cassette, wherein the drain tube includes a drain valve;
a glucose tube for connection of a glucose bag configured to provide concentrated glucose to said fourth port of the cassette, wherein the glucose tube includes a glucose pump for addition of concentrated glucose to the cassette;
whereby the apparatus is configured to replenish glucose to said portion of said peritoneal fluid being returned to the peritoneal cavity from the intermittent bag through said patient tube by said flow pump to maintain a concentration of glucose substantially constant in the peritoneal cavity; wherein
the patient connector, the patient tube, the first port of the cassette, the cassette, the intermittent tube, the intermittent bag, the second port of the cassette, are all arranged without any adsorbent material or dialyzer.

US Pat. No. 10,709,830

REDUCED ROTATIONAL MASS MOTOR ASSEMBLY FOR CATHETER PUMP

TC1 LLC, Pleasanton, CA ...

1. A catheter pump system comprising:an impeller;
a catheter body;
a drive shaft disposed inside the catheter body and coupled with the impeller at a distal portion of the drive shaft, the drive shaft configured such that rotation of the drive shaft causes the impeller to rotate; and
a motor assembly comprising:
a chamber, at least a portion of the chamber in fluid communication with the catheter body, wherein a portion of the drive shaft is disposed in the at least a portion of the chamber;
a rotor disposed in the at least a portion of the chamber;
a stator assembly disposed about the drive shaft and configured to cause the drive shaft to rotate, wherein the catheter body extends from the motor assembly towards the impeller, the motor assembly disposed at a proximal portion of the catheter body; and
a longitudinal rotor lumen disposed through the rotor such that the longitudinal rotor lumen extends on the proximal and distal sides of the rotor, wherein during operation of the catheter pump system, fluid flows through the longitudinal rotor lumen, through the rotor, and through the catheter body.

US Pat. No. 10,709,829

CATHETER PUMP INTRODUCER SYSTEMS AND METHODS

TC1 LLC, St. Paul, MN (U...

1. A catheter system for a catheter pump, comprising:an elongate catheter body having a distal portion including an expandable cannula having an inlet and an outlet, the expandable cannula having a delivery profile and an operational profile larger than the delivery profile;
an expandable impeller assembly disposed in the expandable cannula and including an impeller shaft and an impeller body including one or more impeller blades, the impeller blades drawing fluid into the expandable cannula when rotated in the fluid; and
a retainer sheath configured to be advanced through a vasculature of a patient while containing the expandable cannula and the expandable impeller assembly therein, to deliver the expandable cannula to a target location within the vasculature where it is advanced distally out of the retainer sheath, the retainer sheath comprising:
a distal cannula retention zone disposed over and compressing the expandable cannula and the expandable impeller assembly into the delivery profile, and having a first resistance to separation greater than an outward force generated by the expandable cannula and the expandable impeller assembly under compression, and
a proximal separation zone adjacent the distal cannula retention zone and disposed over the elongate catheter body, the proximal separation zone having a second resistance to a separation force, the second resistance less than the first resistance, wherein upon advancing the expandable cannula distally out of the retainer sheath, the proximal separation zone is configured to separate, under the separation force, into a first portion and a second portion disposed across a gap, the gap enabling the elongate catheter body to pass between the first and second portions to enable removal of the retainer sheath from the elongate catheter body for operation of the expandable impeller assembly.

US Pat. No. 10,709,828

SHEATH DEVICE FOR INSERTING A CATHETER

ECP ENTWICKLUNGSGESELLSCH...

1. A sheath device for inserting a catheter into a patient's body, comprising:a first sheath having a proximal end and a distal end, the distal end of the first sheath configured to be arranged in the patient's body during use and the proximal end of the first sheath configured to be arranged outside the patient's body, the first sheath comprising a tubular section connected to a sheath housing, the sheath housing disposed at a proximal end of the tubular section configured as a receiving channel, and wherein the sheath housing is displaceable relative to the tubular section along a longitudinal axis;
a second sheath configured as a lumen for receiving a medical device and configured to be positioned proximal of the proximal end of the first sheath, wherein a distal end of the second sheath is positioned inside a proximal end of the sheath housing; and
a clamping element on the receiving channel configured to clamp the second sheath in position relative to the first sheath prior to moving the medical device from the second sheath into the receiving channel;
wherein the tubular section is configured to allow for a transfer of the medical device from the second sheath into the tubular section when the tubular section is displaced relative to the sheath housing such that the sheath housing extends proximally beyond the proximal end of the tubular section.

US Pat. No. 10,709,827

MEMBRANE CATHETER

1. A substance exchange device for intracorporal use, comprising:a cavity for receiving blood having at least one blood inlet and at least one blood outlet,
a substance exchange membrane adjoining the cavity,
a supply duct for supplying an exchange fluid to the substance exchange membrane,
a blood pump arranged within the cavity and
a drive unit for the blood pump,
wherein the blood pump is configured to pump blood in a direction from a blood inlet to a blood outlet of the cavity,
wherein the drive unit comprises a turbine, which is connected to the supply duct and may be driven by an exchange fluid supplied via the supply duct, and
wherein the turbine comprises at least a rotor coupled to the blood pump and a stator.

US Pat. No. 10,709,826

CONTROL CIRCUIT AND METHOD FOR NEGATIVE PRESSURE WOUND TREATMENT APPARATUS

1. A negative pressure wound therapy apparatus comprising:a negative pressure source configured to be in fluidic communication with a wound via a fluid flow path, the negative pressure source further configured to supply negative pressure to the wound;
a pressure sensor configured to measure pressure in the fluid flow path; and
control circuitry configured to:
determine a difference between a set negative pressure level and a pressure level measured by the pressure sensor;
based on the difference, generate a control signal configured to operate the negative pressure source to establish or maintain the set negative pressure level in the fluid flow path; and
based on the difference and first and second reference values, selectively generate an override signal configured to override the control signal and prevent the negative pressure source from operating, wherein the control circuitry does not alter the override signal responsive to the difference being between the first and second reference values, and wherein the first reference value is associated with a smaller negative pressure difference than the second reference value.

US Pat. No. 10,709,825

WOUND EXUDATE MONITOR ACCESSORY

ConvaTec Technologies Inc...

1. A stand-alone system for assessing wound exudate from a wound of a patient, said system comprising:a sensor or detector for detecting one or more physiological values of the wound exudate from the wound of the patient;
a processor for comparing the one or more detected physiological values to one or more predetermined physiological values to obtain a comparison result in real time, and for providing an electronic signal based on the comparison result, in which the electronic signal corresponds to guidelines for treating the wound;
a compartment for receiving wound exudate from the wound of the patient;
an exit tube, wherein the compartment is connected to the exit tube;
a valve positioned relative to the exit tube to control removal of wound exudate from the compartment via the exit tube when the wound exudate reaches a set level in the compartment;
a reservoir for receiving the removed wound exudate from the exit tube; and
a transmitter to output the electronic signal for reception by a negative pressure wound therapy device which controls a flow of the wound exudate from the wound of the patient;
wherein the sensor or detector is positioned on an exterior of the exit tube.

US Pat. No. 10,709,824

ACCESSORY PART

Serres Oy, Kauhajoki as....

1. An accessory part to be used in connection with cleaning a suction bag emptying device, the accessory part comprisinga lid for closing a container in the emptying device; and
a capsule with a cavity formed in the lid for holding a liquid agent to be used for cleaning the emptying device, wherein the cavity is closed by a plug extending to an inside of the cavity, and a gap is disposed between a bottom of the cavity and an end of the plug for throttling liquid flow during cleaning, wherein the bottom of the cavity includes radially extending ridges, and wherein the plug is adapted to displace the liquid agent from a mid-area of the cavity and move the liquid agent against a side wall of the cavity.

US Pat. No. 10,709,823

SYSTEM AND DEVICE FOR COLLECTING LIQUIDS

10. A device for collecting liquid, the device comprising:a main container defining a main collecting chamber;
a suction pump port connected to said main container and in fluid communication with said main collecting chamber for establishing a vacuum in said main collecting chamber;
a liquid inlet opening connected to said main container and in fluid communication with said main collecting chamber for drawing liquid into the main collecting chamber through said liquid inlet opening based on the vacuum in said main collecting chamber;
a main duct section connected to said main container, wherein said main duct section is in fluid communication with said main collecting chamber at a location along a liquid fill path of said main collecting chamber;
a water-soluble closing component operatively connected to said main duct section and closing said main duct section such that one portion of main duct section is separated by said water-soluble closing component from the main collecting chamber until said water-soluble closing component is dissolved by contact with liquid, whereby upon liquid filling said main collecting chamber to said location along the liquid fill path, said water-soluble closing component comes into contact with liquid and dissolves such that said one portion of main duct section is not separated from the main collecting chamber.

US Pat. No. 10,709,822

ANTITHROMBOTIC METALLIC MATERIAL

Toray Industries, Inc., ...

1. An antithrombogenic metallic material comprising a metallic material having a surface coated with a non-hemolytic coating material,said coating material comprising:
a phosphonic acid derivative or a catechol derivative;
a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and
an anionic compound containing a sulfur atom and having anticoagulant activity;
said polymer being covalently bound to said phosphonic acid derivative or said catechol derivative and said anionic compound being bound to said polymer by ionic bonding, and
said phosphonic acid derivative or said catechol derivative being bound to said metallic material through a phosphonic acid group or a catechol group thereof,
wherein an abundance ratio of nitrogen atoms to an abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface coated with the coating material is 4.0 to 13.0 atomic percent,
the phosphonic acid derivative is a carboxyalkylphosphonic acid or aminoalkylphosphonic acid, and the catechol derivative is a compound of General Formula (IV), a compound of General Formula (V), a compound of General Formula (VI), or a compound of General Formula (VII):

US Pat. No. 10,709,821

SEALING STRUCTURE FOR HEART VALVE IMPLANTS

BIOTRONIK AG, Buelach (C...

1. A heart valve implant comprising a supporting stent, a heart valve element, and a skirt, wherein the skirt comprises or is formed of at least one molded body, wherein the at least one molded body is made of dried treated bacterial cellulose that has a swelling capacity that is greater than untreated bacterial cellulose of the same type, wherein a selected one of the at least one molded body has at least one area that has a lower swelling capacity than an adjacent area of the same selected one of the at least one molded body.

US Pat. No. 10,709,819

METHOD FOR COATING CATHETERS WITH A LAYER OF ANTIMICROBIAL AGENT

VALENCIDE LLC, San Diego...

1. An elastomeric medical device that reduces the development of device-associated urinary tract, respiratory and bloodstream infections cause by one or more microorganisms, the device comprising:a medical device having an inner surface and an outer surface, wherein said outer surface is coated with an aromatic polyether-based thermoplastic polyurethane in a tetrahydrofuran solution to form a barrier when dried;
an exterior surface of the barrier comprising one or more polyiodinated resins coated thereon, said one or more resins having a base polymer comprising an anion exchange resin, each of said resins being dispersed in a tetrahydrofuran/acetone solution of polyurethane;
wherein said one or more resins are allowed to dry to form a solid outer coating;
wherein the barrier serves to prevent leaching and to control a release of active ingredients of said one or more resins of the medical device for antimicrobial efficacy;
wherein said solid outer coating releases a polyiodide anion from said anion exchange resin which on contact with one or more microorganisms, exerts a toxic effect thereon without being toxic to a user;
the release of said polyiodide anion only occurring when said one or more microorganisms, being drawn to the iodine, makes contact therewith, thereby avoiding spontaneous release of active ingredients and enabling sustained availability of said active ingredients; and
wherein said contact results in a 4 log reduction of said microorganisms.

US Pat. No. 10,709,818

MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS

MASSACHUSETTS INSTITUTE O...

1. A composition comprising a preparation of hydrogel capsules encapsulating cells that secrete a therapeutically effective substance,wherein the mean diameter of the capsules in the preparation is between 1 mm and 5 mm, and at least 50% of the capsules in the preparation have a sphere-like shape,
wherein the capsules comprise a modified alginate polymer comprising one or more covalently modified monomers defined by Formula I
whereinX is selected from the group consisting of oxygen, sulfur, and NR4,
R1 is —R6—Rb,
R6 is
i)

wherein R18, R19, R20, R21, R22, and R23 are independently C, O, N, S, S(O), or S(O)2, wherein the bonds between adjacent R18 to R23 are double or single according to valency, and wherein R18 to R23 are bound to none, one, or two hydrogens according to valency,
R24 is —(CR25R25)p— or —(CR25R25)p—Xb—(CR25R25)q—, wherein p is 0 to 5, q is 0 to 5, each R25 is independently hydrogen or C1-C3 alkyl, and Xb is O,
each Rd and Re is independently alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, substituted alkynyl, alkoxy, alkylamino, dialkylamino, hydroxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted alkoxy, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, or substituted heterocyclic, y is an integer from 0 to 11, w is an integer from 0 to 11, or
ii)

wherein R10, R11, R12, R13, R14, R15, R16, and R17 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, poly(ethylene glycol), or poly(lactic-co-glycolic acid); k is an integer from 0 to 20, each Xd is independently absent, O, or S, and Rc is Rb,
Rb is:

wherein R8 and R9 are independently hydrogen or

wherein R8 and R9 are not both hydrogen,
Y1 and Y2 independently are hydrogen or —PO(OR5)2, or
Y2 is absent, and Y1, together with the two oxygen atoms to which Y1 and Y2 are attached form a cyclic structure as shown in Formula IV
whereinR2 and R3 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), poly(lactic-co-glycolic acid), peptide, or polypeptide group, or
R2 and R3, together with the carbon atom to which they are attached, form a 3- to 8-membered unsubstituted or substituted carbocyclic or heterocyclic ring, and
R4 and R5 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), poly(lactic-co-glycolic acid), peptide, or polypeptide group.

US Pat. No. 10,709,816

IMPLANT

Medizinische Hochschule H...

1. Implant useful for bone in-growth consisting exclusively of a sintered bulked volume of packed layers of scattered fibers of a magnesium master alloy containing greater than 50% magnesium and excluding each of aluminium, copper, and nickel except in traces of maximally 1%, wherein the fibers have a length ranging from 2 mm to 15 mm and are securely connected to each other by sintered bridges that are locally spaced vis-à-vis one another and thereby form an open-pored body, which implant disintegrates in a living being through biological adsorption.

US Pat. No. 10,709,814

OSTEOIMPLANT COMPRISING AN INSOLUBLE FIBROUS POLYMER

Warsaw Orthopedic, Inc., ...

1. A method for making an osteoimplant, the method comprising: applying a mechanical force using a grinder or a blender to an aqueous slurry of insoluble collagen fibers to entangle the insoluble collagen fibers so as to form a semi-solid mass of entangled insoluble collagen fibers, the aqueous slurry of insoluble collagen fibers being purified fibrillary collagen; mixing the semi-solid mass of entangled collagen fibers with a gel comprising starch or alginate, and polyethylene glycol (PEG) and deionized water to form a mixture; mixing the mixture with ceramic granules having biphasic calcium phosphate comprising tricalcium phosphate and hydroxyapatite in a ratio from about 40:60 to about 95:5; placing the mixture in a mold; and lyophilizing the mixture to form the osteoimplant by placing the mold in a freeze dryer; wherein the method comprises mixing PEG in deionized water with the gel to form a solution before adding the slurry to form the mixture; and then adding the biphasic calcium phosphate to the mixture.

US Pat. No. 10,709,812

BIODEGRADABLE HYDROGEL FOR TISSUE EXPANSION

THE REGENTS OF THE UNIVER...

1. A method of achieving tissue expansion in a patient in need thereof, the method comprising:injecting the patient with a biodegradable hydrogel scaffold comprising a perfluorocarbon (PFC) emulsion at a site in need of tissue expansion, wherein the PFC emulsion vaporizes from liquid droplets into gas bubbles in response to body heat in the absence of ultrasound, wherein the biodegradable hydrogel scaffold polymerizes to form a solid structure at the site, expands causing tissue expansion, and subsequently degrades in the patient,
wherein the scaffold is not exposed to ultrasound.

US Pat. No. 10,709,810

PROCESSED ADIPOSE TISSUE

LifeCell Corporation, Ma...

1. A method of producing a tissue product, comprising:providing a sheet of tissue comprising adipose-containing transitional dermis;
treating the sheet of tissue to remove substantially all cellular material from the tissue; and
processing the sheet of tissue to partially remove lipid components such that the tissue product retains at least about 35% lipid content as a percentage of the overall tissue product by mass following processing.

US Pat. No. 10,709,809

MULTI-LAYER ADHESIVE TAPE TO COMPRESS AND CONTRACT A SCAR

Michel Heymans, Grez Doi...

1. A multi-layer adhesive tape to compress and contract a scar, said multi-layer adhesive tape comprising:a flexible top layer,
a bonding layer,
a flexible bottom layer which comprises an adhesive layer to cover the scar, said flexible bottom layer and said flexible top layer being bound to each other by said bonding layer,
wherein said flexible top layer has a width greater than a width of said flexible bottom layer so as to cover an entire width of said flexible bottom layer,
wherein said flexible top layer has a thickness of between 20 ?m and 1100 ?m, and is configured to achieve, upon application of the multi-layer adhesive tape on the scar, a positive pressure P defined by the force applied by the flexible top layer on a surface of the scar, in accordance with the following pressure equation:

where,
P corresponds to the pressure applied by the multi-layer adhesive tape on the scar,
? corresponds to the relative deformation of the flexible top layer and,
E represents the Young's modulus of the flexible top layer,
h represents the thickness of the flexible top layer,
L represents the width of the flexible bottom layer, and
the angle ? is defined between one of the ends of the flexible top layer and the surface of the scar.

US Pat. No. 10,709,807

POROUS DEVICES, KITS, AND METHODS FOR DEBRIDEMENT

3M Innovative Properties ...

1. A device comprising:(a) a particle-containing porous fibrous nonwoven matrix comprising:
(i) a porous fibrous nonwoven matrix in the form of a layer of interlaid fibers comprising first polyolefin fibers, second polyolefin fibers comprising polyethylene, and fiberglass fibers; and
(ii) a plurality of microorganism-binding particles; wherein the particles are enmeshed in the porous fibrous nonwoven matrix; and
(b) a fluid absorbed in the particle-containing porous fibrous nonwoven matrix.

US Pat. No. 10,709,806

BIODEGRADABLE ABSORBENT ARTICLES

1. A disposable absorbent article comprising:a non-woven inner layer consisting of 100% cellulosic fibers;
a hydrophobic non-woven outer layer, the hydrophobic non-woven outer layer consisting of:
a) 100% cellulosic fibers treated with an internal hydrophobic agent, the internal hydrophobic agent is a dendrimer wax; and
b) an external hydrophobic surface treatment applied to a surface of the non-woven outer layer, the external hydrophobic surface treatment selected from the group consisting of waxes, urethanes, silicones, fluorocarbons, non-fluorochemical repellents, and combinations thereof, and
a core comprising natural fibers or fibrous material positioned between the non-woven inner layer and the non-woven outer layer.

US Pat. No. 10,709,805

WALL MOUNTABLE ESSENTIAL OIL DIFFUSER

1. A wall mountable essential oil diffuser, the wall mountable essential oil diffuser comprising:a housing;
a wall dock, wherein the wall dock is configured to:
attach to a surface; and
releasably receive at least a portion of the housing;
an aperture, wherein the aperture is configured to receive an essential oil container;
means for vaporizing the essential oil in the container, wherein the means for vaporizing the essential oil in the container is configured to increase the vaporization rate of essential oil within the essential oil container;
an outlet, wherein the outlet is configured to receive the vaporized essential oil and allow the vaporized essential oil to exit the housing;
a switch, wherein the switch is configured to allow a user to turn on and off the means for vaporizing the essential oil in the container;
a power supply, wherein the power supply is configured to provide power to at least the means for vaporizing the essential oil in the container; and
a power button, wherein the power button is configured to control whether the power supply is sending power to at least the means for vaporizing the essential oil.

US Pat. No. 10,709,803

STERILIZATION APPARATUS AND ADAPTIVE CONTROL THEREOF

TS03 Inc., Quebec (CA)

1. An apparatus for sterilizing a load, comprisinga sterilization chamber,
a vacuum arrangement for applying a vacuum in the sterilization chamber,
a sterilant injection arrangement for admitting a sterilant gas into the sterilization chamber when under vacuum;
a monitoring arrangement for detecting an occurrence of condensation in the chamber by monitoring a sterilant condensation related parameter in the sterilization chamber during admission of the sterilant gas and for determining a value of the condensation related parameter upon detecting the occurrence of condensation in the chamber; and
a control unit connected to the monitoring arrangement programmed to select a sterilization cycle among a plurality of predetermined sterilization cycles according to the value of the condensation related parameter detected by the monitoring arrangement.

US Pat. No. 10,709,802

WATER AND ENERGY EFFICIENT MEAT PROCESSING TOOL SANITIZER

1. A sanitizing system for instantaneous hot water immersion of an unsanitary food preparation tool comprising:a primary open-top {i.e. unpressurized} basin having a bottom and one or more surrounding walls to form a vessel with a depth;
a probe which determines a present temperature of first liquid contained in the primary basin;
a switch configured to receive a signal from the probe, and to generate a valve-open signal when the present temperature falls to a first temperature value;
a controllable valve receiving a second liquid at a pre-determined food-grade instantaneous immersion sanitizing temperature, thereby allowing the second liquid to flow into the first liquid within the open-top primary basin responsive to receiving the valve-open signal, and interrupting the flowing responsive to not receiving the valve-open signal; and
a first overflow drain to exhaust water from the primary basin responsive to overfilling during the open-valve flowing;
thereby automatically maintaining the present temperature of the first liquid held in the primary basin at a temperature for food-grade instantaneous immersion sanitization of food preparation tools and machine parts;
wherein the first liquid and the second liquid consist essentially of water.

US Pat. No. 10,709,800

RADIO-OPAQUE WRITING INSTRUMENTS AND METHODS OF USE

1. A composition for use in marking a surface in connection with an imaging-assisted medical procedure, comprising:a first radio-opaque component comprising a first radio-opaque material dissolved in a solvent; and
a second radio-opaque component comprising a second radio-opaque material dispersed throughout a carrier,
the first radio-opaque material and the second radio-opaque material comprising different radio-opaque materials with different radio-opaque characteristics.

US Pat. No. 10,709,798

CRYSTALLIZATION PROCESS OF TRICYCLIC INDOLE DERIVATIVES

GE HEALTHCARE LIMITED, B...

1. A method of obtaining a composition comprising a compound of Formula Ia:wherein:R1 is a halogen;
R2 is C1-3 alkoxy;
R7 and R8 are C1-6 alkyl; and
A1 is a bond or C1-10 alkylene, and R9 is a leaving group, or R9 is the group —O—R10 wherein R10 is hydrogen, C1-3 alkyl, C3-6 aryl, C7-10 arylalkyl, or a hydroxyl protecting group,
wherein said composition comprises no more than 1% of a compound of Formula IIa:

wherein each of R2, R7, R8, R9 and A1 are as defined for Formula Ia, the method comprising:
crystallizing the composition from an organic solvent in the presence of the catalytic amount of N,N-diisopropyl ethylamine, triethyl amine, or diethyl amine to obtain said composition, wherein the composition comprises the compound of Formula Ia and no more than 1% of the compound of Formula IIa as a by-product.

US Pat. No. 10,709,797

ISOLATION OF EXTRACELLULAR VESICLES (EVS) FROM RED BLOOD CELLS FOR GENE THERAPY

CITY UNIVERSITY OF HONG K...

1. A method for RNA delivery to leukemic or breast cancer target cells comprising:a) purification of extracellular vesicles (EVs) from red blood cells (RBCs) using ultracentrifugation with a sucrose cushion, wherein the RBCs have been treated overnight with calcium ionophore;
b) electroporation of the EVs with RNAs to form RNA-loaded EVs; and
c) applying the RNA-loaded EVs to the target cells.

US Pat. No. 10,709,794

PHOTODYNAMIC THERAPY COMPOSITION

CASE WESTERN RESERVE UNIV...

1. A method of treating cancer comprising:(a) administering to a subject with cancer a therapeutically effective amount of a composition comprising a pharmaceutical composition comprising a phthalocyanine compound or targeted conjugate thereof having the formula (I):

wherein X1 is hydrogen or includes a targeting moiety directly or indirectly coupled or conjugated to the thiol group;
R1, R4, R5, R8, R9, R12, R13, and R16 are each independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, thiol, amino, and methyl;
R2, R3, R6, R7, R10, R11, R14, and R15 are each independently selected from the group consisting of hydrogen, halogen, nitro, cyano, hydroxyl, thiol, amino, carboxy, aryl, heteroaryl, carbocyclyl, heterocyclyl, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy, C1-6 acyl, C1-6 alkylcarbonyloxy, C1-6 carbocyclylalkyl, C1-6 aminoalkyl, alkylamino, C1-6 thioalkyl, C1-6alkylthio, C1-6hydroxyalkyl, C1-6 alkyloxycarbonyl, C1-6 alkylaminocarbonyl, and C1-6 alkylcarbonylamino; and pharmaceutically acceptable salts thereof; and
(b) exposing the phthalocyanine compound or targeted conjugate thereof to light, thereby inducing the cytotoxic effects of the phthalocyanine compound or targeted conjugate thereof.

US Pat. No. 10,709,792

PASSIVATED MAGNETIC NANOPARTICLES FOR CELL TARGETING AND METHODS OF PREPARATION AND USE

VERILY LIFE SCIENCES LLC,...

1. A functionalized magnetic nanoparticle, comprising:a. a magnetic nanoparticle;
b. a poly(ethylene glycol) (PEG) passivation layer encapsulating the magnetic nanoparticle, wherein the PEG passivation layer comprises at least about 50 picomoles/cm2 of PEG and wherein the PEG comprises at least one attachment site;
c. a first chemical attachment moiety attached to the at least one attachment site of PEG; and
d. a functional moiety, wherein the functional moiety comprises a second chemical attachment moiety attached to the first chemical attachment moiety.

US Pat. No. 10,709,791

STABILIZED POLYMERIC CARRIERS FOR THERAPEUTIC AGENT DELIVERY

University of Washington,...

1. A copolymer having the formula:
wherein
R1 and R2 are independently selected from hydrogen and methyl,
S is a poly(ethylene oxide) group,
X is O or NH,
D is a therapeutic agent,
C1 is a cleavable linkage,
L1 is a linker that covalently couples C1 to X,
C2 at each occurrence is an independent cleavable linkage,
L2 is a linker that covalently couples C1 to C2,
n is 0 or 1,
a is an integer from about 5 to about 500,
b is an integer from about 5 to about 500, and
each * represents the copolymer terminus,
wherein C1 and C2 are independently selected from the group consisting of a phenyl ester, an acetal, a hemiacetal, a hemiacetal ester, a hydrazine, and an amino acid sequence cleavable by enzymatic action.

US Pat. No. 10,709,790

CHEMICAL CONJUGATES OF EVANS BLUE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF LONG-ACTING THERAPEUTICS

THE UNITED STATES OF AMER...

1. A compound of Formula I or a pharmaceutically acceptable ester, amide, solvate, or salt thereof, or a salt of such an ester or amide or a solvate of such an ester, amide, or salt,
wherein:
R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are chosen independently from hydrogen, halogen, hydroxyl, cyano, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, and C1-C6haloalkoxy; and
L1 is —(CH2)m— wherein m is an integer from 0 to 12, wherein each CH2 can be individually replaced with —O—, —NH(CO)—, or —(CO)NH—, providing no two adjacent CH2 groups are replaced, and wherein L1 is optionally substituted with 1 substituent -A-B—X, wherein A is a bond, —NH—, —NH(CO)—, —(CO)NH—, B is C0-12alkyl, or phenylC0-12alkyl, and X is a hydrogen, halogen or an Sn derivative, and wherein when m is 0, the compound additionally comprises a radionuclide.

US Pat. No. 10,709,788

CHITOSAN MAGNETIC PARTICLE DRUG CARRIER, DRUG STRUCTURE, AND METHOD OF MAKING

1. A drug carrier, comprising:90 to 110 parts by weight of a negatively charged polymer;
400 to 1250 parts by weight of chitosan; and
150 to 500 parts by weight of magnetic particles.

US Pat. No. 10,709,785

HIGH LOAD DISPERSIONS

AUSTIN RESEARCH LABS CORP...

1. A method of making an antimicrobial carrier system comprising the steps of:a) dry mixing a layered hydrous magnesium silicate clay and a quaternary ammonium compound to produce a mixture;
b) adding water to said mixture to form a suspension; and
c) incubating said suspension in said water to form a dispersion.

US Pat. No. 10,709,783

NEUTRON CAPTURE THERAPY SYSTEM FOR ELIMINATING AMYLOID ?-PROTEIN

NEUBORON MEDTECH LTD., N...

1. A neutron capture therapy system for eliminating amyloid ?-protein, comprising:a neutron capture therapy device, and
a compound for specifically binding to the amyloid ?-protein,
wherein the compound contains a nuclide with a large thermal neutron capture cross section; and wherein the energy generated by the action of a neutron beam generated by the neutron capture therapy device on the nuclide of the compound destroys the structure of the amyloid ?-protein, and
wherein the compound for specifically binding to the amyloid ?-protein has a structure of formula I:
wherein B in the B(OH)2-group of the formula I is 10B.

US Pat. No. 10,709,778

VACCINE FORMULATION FOR OCULAR IMMUNIZATION

1. A method of treating a subject by active immunotherapy, comprising the steps of:providing a vaccine comprising a subunit vaccine antigen in an amount which is effective to provoke a protective immune response in the subject, chitosan, and an adjuvant, wherein the subunit vaccine antigen is tetanus toxoid (TTd) and wherein the adjuvant is whole cell Bordetella pertussis which has a particle size of >300 nm; and
administering the vaccine to the subject onto the ocular surface in order to enhance a protective immune response on the ocular surface by inducing SIgA antibodies against the subunit vaccine antigen in the subject.

US Pat. No. 10,709,757

PHARMACEUTICAL COMPOSITION FOR ANTI-ANGIOGENESIS CONTAINING CYCLIC PENTADEPSIPEPTIDE AS AN EFFECTIVE INGREDIENT

CHUNG-ANG UNIVERSITY INDU...

1. A method for inhibiting angiogenesis, wherein the method comprises administering a pharmaceutical composition for inhibiting angiogenesis, comprising an isolated cyclic pentadepsipeptide of the following Chemical Formula 1 as an effective ingredient, to a subject in need thereof,
wherein the peptadepsipeptide inhibits the proliferation of vascular endothelial cells.

US Pat. No. 10,709,756

TREATING SEXUAL DYSFUNCTION

Olive Therapeutics, LLC, ...

1. A method comprising: administering to a woman suffering from sexual dysfunction intranasal oxytocin and sublingual buspirone, so that the subject receives combination therapy with both.

US Pat. No. 10,709,753

METHOD OF INHIBITING ANGIOGENESIS

DAIWA PHARMACEUTICAL CO.,...

1. A method of inhibiting angiogenesis by human vascular endothelial cells (HUVECs) in a subject in need thereof, by administering to a site in the subject comprising the inhibitor, wherein the angiogenesis inhibitor is produced by a process comprising:I. a first step of obtaining a water-soluble polysaccharide extract, by
a) obtaining rice bran;
b) extracting the starch from the rice bran;
c) contacting the starch with a glucoamylase to digest the starch, thereby making water-soluble polysaccharides; and
d) separating the water-soluble polysaccharides from the mixture in step (c), thereby making the water-soluble polysaccharide extract;
II. a second step of:
e) adding ammonium sulfate to a culture filtrate prepared by culturing Lentinus edodes of basidiomycetes, thereby precipitating an enzyme complex from the culture filtrate, and
f) harvesting the enzyme complex from the precipitate; and
III. a third step of biologically modifying the water-soluble polysaccharide extract obtained in step (I) by adding the enzyme complex obtained in step (II) to the water-soluble polysaccharide extract obtained in step (I), and causing the mixture to react at a pH of 4.0 to 5.0 for 30 to 60 min and further to react at a pH of 5.5 to 6.5 for 30 to 60 min.

US Pat. No. 10,709,725

GEMCITABINE PROTIDE HYPOXIA-ACTIVATED PRODRUG AND APPLICATION THEREOF

JIANGSU QIANZHIKANG BIOLO...

1. A gemcitabine ProTide hypoxic-activated prodrug, wherein the chemical structural formula of the gemcitabine ProTide hypoxic-activated prodrug is:wherein one of R1 and R2 is a hypoxic-activated group of —C(R3R4)ArNO2, the other of R1 and R2 is an alkyl group of 1 to 6 carbon atoms, a phenyl group or —CH2Ar, R3 and R4 are —H or a methyl group, and —Ar is an aromatic ring compound.

US Pat. No. 10,709,722

FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO

BACH BIOSCIENCES, LLC, C...

1. A pharmaceutical preparation for intravenous administration, comprising a buffering solution having dissolved therein a prodrug represented by Formula I, or a lyophilized preparation of the prodrug for forming an intravenous solution:
or a pharmaceutically acceptable salt thereof, wherein:
R1 represents (C1-C10)alkyl, (C1-C10)alkoxy, (C1-C10)alkyl-C(O)(C1-C10)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, aryl, aryl(C1-C10)alkyl, heteroaryl, or heteroaryl(C1-C10)alkyl, wherein any R1 is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, carboxylate, cyano, amino, nitro, and —SH;
or
represents an N-terminally blocked alpha amino acid residue, wherein X is O;R2 represents H or a (C1-C6)alkyl;
R3 represents a (C1-C6)alkyl;
R4 is absent or represents a (C1-C6)alkyl, —OH, —NH2, or halogen;
X represents O or S;
L represents a bond,
or
represents a self-immolative linker; andCyt? represents a radical of an anthracycline or derivative thereof.

US Pat. No. 10,709,719

SUBSTITUTED BICYCLIC COMPOUNDS

Bristol-Myers Squibb Comp...

1. A compound of Formula (II):
or a salt thereof, wherein:
R1 is —OH or —OP(O)(OH)2;
X1, X2, and X3 are:
(i) X1 is O, X2 is CH2, and X3 is CH2;
(ii) X1 is CH2, X2 is O, and X3 is CH2;
(iii) X1 is CH2, X2 is CH2, and X3 is O; or
(iv) X1 is O, X2 is CH2, and X3 is O;
R2a is —(CH2)3-6CH3, —(CH2)1-4CH?CRxRx, (CH2)1-4CH?CRx(CH2CH3), —CH?CH(CH2)1-3C(Rx)3, —CH?CH(CH2)1-3OCH3, —(CH2)1-3CH?CHCH?CRxRx, —CH?CH(CH2)1-3CH?CRxRx, —CH?CHRz, —(CH2)1-3Rz, —(CH2)1-3O(CH2)0-3Rz, —(CH2)1-3S(CH2)0-3Rz, —CH2S(O)Rz, —CH2S(O)2Rz, —O(CH2)1-2Rz, —O(CH2)1-2O(CH2)0-2Rz, —OC(O)Rz, —(CH2)1-4O(CH2)0-9C(Rx)3, —(CH2)1-4O(CH2)0-9CF3, —(CH2)1-4CRxRxO(CH2)0-4C(Rx)3, —(CH2)1-3O(CH2)1-4CH?CRx(CH2)0-3CH3, —(CH2)1-3O(CH2)1-4CH?CRxRx, —(CH2)1-3O(CH2)1-4C(OH)RxRx, —(CH2)1-3O(CH2)1-4O(CH2)0-3CH3, —(CH2)1-3S(CH2)0-4C(Rx)3, —(CH2)0-3O(CH2)1-4S(CH2)0-3C(Rx)3, —(CH2)1-3S(CH2)1-4Si(CH3)3, —(CH2)1-3S(O)(CH2)0-4C(Rx)3, —(CH2)1-3S(O)2(CH2)0-4C(Rx)3, —(CH2)1-5NRxRx, —O(CH2)1-7C(Rx)3, —O(CH2)1-4O(CH2)0-4C(Rx)3, —O(CH2)1-4CH?CRx(CH2)0-3CH3, —O(CH2)1-4O(CH2)0-3C(Rx)3, —O(CH2)1-4O(CH2)1-3CH?CRxRx, —O(CH2)1-4O(CH2)1-3C?CRx, —C(O)(CH2)0-4C(Rx)3, —OC(O)(CH2)0-4C(Rx)3, —OC(O)CRxRx(CH2)0-4C(Rx)3, —OC(O)NRx(CH2)0-5C(Rx)3, —NRxC(O)NRx(CH2)0-5C(Rx)3, —C(CH3)?N—O(CH2)0-5C(Rx)3, —C(CH3)?N—O(CH2)1-2(phenyl), —C(CH3)?N—O(CH2)1-2(fluorophenyl), —C(CH3)?N—O(CH2)1-2(methoxyphenyl), phenyl, or pyridinyl;
each Rx is independently H or —CH3; and
Rz is phenyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolinyl, thiophenyl, thiazolyl, oxetanyl, C3-6 cycloalkyl, adamantanyl, or tetrahydropyranyl, each substituted with zero to 4 substituents independently selected from F, Cl, I, C1-4 alkyl, —O(C1-3 alkyl), —CF3, —OCF3, —(CH2)1-6OCH3, —CH2NRxRx, —C(O)NRxRx, —C(O)NRx(C1-4 alkyl), and —CH2C(O)NRxRx.

US Pat. No. 10,709,718

INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE 1 (DGAT-1) AND USES THEREOF

Metabasis Therapeutics, I...

1. A compound of Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof,Q-G1-G2-G3-G4-Z   Formula (I)
wherein Q is:

A is a fused ring selected from an aromatic 6-membered ring containing 2 N atoms;
L is N or C(R8); the number of R8 substituents on A ring is 0, 1, 2 or 3;
R8 is independently selected from halo, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C8)alkynyl, aryl, heteroaryl, (C3-C8)cycloalkyl, cyano, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —ORa, —O—C(O)(Ra), —S(Ra), —S(O)(Rb), —S(O)2(Rb), —C(O)(Ra), —C(O)(ORa), —N(Ra)2, —N(Ra)—C(O)(Ra), —(O)N(Ra)2, —S(O)2N(Ra)2, —(CRaRb)LORa, —(CRaRb)rO—C(O)(Ra), —(CRaRb)tS(Ra), —(CRaRb)tS(O)(Rb), —(CRaRb)tS(O)2(Rb), —(CRaRa)tC(O)(Ra), —(CRaRb)tC(O)(ORa), —(CRaRb)rN(RaRb), —(CRaRb)tN(Ra)—C(O)(Ra), —(CRaRb)tC(O)N(Ra)2, —(CRaRa)tS(O)2N(Ra)2 or —(CRaRb)tRa, wherein t is an integer of 1, 2, 3, or 4; and
Ra and Rb are independently selected from the group consisting of H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, fluoro(C1-C8)alkyl, (C3-C8)cycloalkyl, aryl, heteroaryl and aryl(C1-C4)alkyl;
G1 is arylene;
G2 is a bond;
G3 is cyclo(C3-C8)alkylene;
G4 is —X—Y—;
wherein X is selected from null, O, NH, CO, CHOH, S or S(O)2; and Y is selected from (C1-C4)alkylene, C3-C8-cycloalkylene, heterocycloalkylene, —CH(R9)C(R10R11)— or —N(R9)C(R10R11)—;
wherein:
i) R10 and R11 are both hydrogen, and R9 is hydrogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, phenoxy-(C2-C6)alkyl, 1-methyl-1H-indol-3-yl, bis[(C1-C6)alkyl]amino-(C2-C6)alkyl, 1-piperidinyl-(C2-C6)alkyl, 1-pyrrolidinyl-(C2-C6)alkyl, or 1-morpholinyl-(C2-C6) alkyl; or R10 and R11 are both hydrogen and R9 is R12(CH2)m, where m is 0 to 3, and R12 is phenyl optionally substituted with one or more halogen, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl or cyano; or
ii) R10 and R11 are both hydrogen and R9 is R12(CH2)m, where m is 0 to 3, and R12 is 2-pyridinyl, 3-pyridinyl, or 4-pyridinyl, each of which is optionally substituted with halogen, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl or cyano; or
iii) R9 is hydrogen, and R10 and R11 together with the carbon atom to which they are attached, form a three to five-membered ring, with 0 to 2 heteroatoms independently selected from O, S or N; or
iv) R10 is hydrogen, and R9 and R11 together with the two carbon atoms to which they are attached, form a three- to six-membered ring with 0 to 2 heteroatoms independently selected from O, S or N;
Z is Z1 or Z2; and
Z1 is

X1 and X2 are independently selected from null, (C(RaRb))n, O, NRa, S or CO and n is 0 or 1; W is selected from H, (C1-C6)alkyl, aryl, heteroaryl or (C3-C8)cycloalkyl; wherein each of the (C1-C6)alkyl, aryl, heteroaryl and cycloalkyl is independently substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, —CN, halogen, ethylenedioxy, methylenedioxy, haloalkyl, —ORa, —O—C(O)(Ra), —S(Ra), —S(O)(Rb), —S(O)2(Rb), —C(O)(Ra), —C(O)(ORa), —N(Ra)2, —N(Ra)—C(O)(Ra), —C(O)N(Ra)2, —S(O)2N(Ra)2, —(CRaRb)tORa, —(CRaRb)t—O—C(O)(Ra), —(CRaRb)tS(Ra), —(CRaRb)tS(O)(Rb), —(CRaRb)tS(O)2(Rb), —(CRaRa)tC(O)(Ra), —(CRaRb)tC(O)(ORa), —(CRaRb)tN(RaRb) —(CRaRb)tN(Ra)—C(O)(Ra), —(CRaRb)tC(O)N(Ra)2, —(CRaRa)tS(O)2N(Ra)2, —(CRaRb)tRa, —(CRaRb)tP(O)(OH)2, and —(CRaRb)tP(O)(OH)(Ra), wherein t is an integer of 1, 2, 3, or 4; or X1 and X2 may be combined to form a 5-, 6- or 7-membered ring having from 0 to 3 heteroatoms selected from the group consisting of NRa, O and S; or X1 or X2 may be combined with W to form a 5-, 6- or 7-membered fused ring having from 0 to 3 heteroatoms selected from the group consisting of NRa, O and S; and
Z2 is Z1, H, —OH, CO2Ra or —C(O)N(Ra)2;
with a proviso that when X2 is O, then X1 is not (C(RaRb))n.

US Pat. No. 10,709,717

POLYMER COMPOSED OF REPEAT UNITS HAVING A BIOLOGICALLY ACTIVE MOLECULE ATTACHED THERETO VIA A PH-SENSITIVE BOND

SPIREA LIMITED, Harrogat...

1. A particle which is a microparticle or a nanoparticle having an average diameter of 1 nm to 10 microns and comprising a linear polymer, wherein said linear polymer comprises a repeat unit of formula MTV
wherein:
each n is independently 0 or an integer from 1 to 6;
each m is independently 0 or an integer from 1 to 4, and at least one m is 1;
---- is a bond which is absent or present;
each D is a moiety which is a biologically active molecule, or a derivative thereof, when the C to D bond(s) is broken;
each q is an integer from 1 to 8;
X is selected from O, S, NH and NR?;
Y is selected from O, S, NH and NR?;
R? is C1-20 hydrocarbyl;
Q is selected from —(CH2)p—, —(CH2CH2O)sCH2CH2—, —(CH2)rNR?—(CH2)r— and —(CH2CH2CH2O)sCH2CH2CH2—; and each of p, r and s is independently an integer from 1 to 16;
wherein release of said biologically active molecule, or a derivative thereof, from the linear polymer is pH sensitive and is dependent upon the nature of the bond between said biologically active molecule and the repeat unit of the linear polymer to which it is covalently bound; and
wherein the particle enables the delivery in vivo of said linear polymer comprising a biologically active molecule or derivative thereof inside a target cell, in which the biologically active molecule or derivative thereof is cleaved from the linear polymer by an acidic and/or hydrolytic environment.

US Pat. No. 10,709,716

17-HYDROXYPROGESTERONE ESTER-CONTAINING ORAL COMPOSITIONS AND RELATED METHODS

Lipocine Inc., Salt Lake...

1. A method of treating a pregnant female at risk of having a preterm birth, said method comprising administering to a pregnant female having one or more serum biomarkers that indicate said pregnant female is at risk of preterm birth a pharmaceutical composition comprising a therapeutically effective amount of 17-hydroxyprogesterone caproate and a pharmaceutically acceptable carrier comprising a lipophilic additive selected from benzyl benzoate, castor oil and mixtures thereof, said lipophilic additive comprising at least 50 weight/weight percent (w/w %) of the carrier and said pharmaceutical composition having 50 w/w % or less castor oil and 50 w/w % or less benzyl benzoate wherein said pharmaceutical composition is prepared by combining castor oil, benzyl benzoate and 17-hydroxyprogesterone caproate with the proviso that benzyl alcohol is not combined with the pharmaceutical composition.

US Pat. No. 10,709,712

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

NOVARTIS AG, Basel (CH)

1. A method of treating a proliferative disease mediated by B-Raf or C-Raf in a patient having said disease, comprising administering to a patient in need thereof a therapeutically effective amount of a compound which isor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,709,711

HIGHLY ACTIVE ANTI-NEOPLASTIC AND ANTI-PROLIFERATIVE AGENTS

G1 Therapeutics, Inc., R...

1. A method of treating T-cell leukemia in a human in need thereof comprising administering to the host an effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereofwherein the T-cell leukemia is acute lymphoblastic leukemia (ALL).

US Pat. No. 10,709,709

SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS

Pfizer Inc., New York, N...

1. A method of treating cancer in a mammal, the method comprising administering to the mammal in need thereof a therapeutically effective amount of the compound (1S,2S,3S,5R)-3((6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl)oxy)-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, having the structure:or a pharmaceutically acceptable salt thereof wherein said cancer is selected from bladder cancer, breast cancer, cervical cancer, endometrial cancer, esophageal cancer, leukaemia, lung cancer, lymphoma, ovarian cancer, pancreatic cancer, stomach cancer, cancer of the vulva, and head and neck cancer.

US Pat. No. 10,709,708

METHOD OF TREATING CANCER WITH A COMBINATION OF MER TYROSINE KINASE INHIBITOR AND AN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR

The University of North C...

1. A method of treating tumors, wherein said tumors comprise non-small cell lung cancer tumors in a mammalian subject in need thereof, comprising:concurrently administering to said subject a MER tyrosine kinase inhibitor and an Epidermal Growth Factor Receptor (EGFR) inhibitor, wherein said MER tyrosine kinase inhibitor is
or a pharmaceutically acceptable salt thereof, and said EGFR inhibitor is Osimertinib (AZD-9291), and wherein said MER tyrosine kinase inhibitor is administered to said subject in an amount effective to enhance the efficacy of said EGFR inhibitor in treating said tumors.

US Pat. No. 10,709,706

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

Karopharm Therapeutics In...

1. A compound of structural formula (Ia), (Ib), or (Ic):
or a pharmaceutically acceptable salt thereof, wherein:
each R1, if present, is independently selected from —CF3, halo, —OH, C1-C3 alkyl, C3-C6 cycloalkyl, 3-18-membered heterocyclyl, halo-C1-C3 alkyl, —NH2, —NO2, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)(C1-C3 alkyl), —C(O)OH, —C(O)O—(C1-C6 alkyl), —C(O)—(C1-C3 alkyl), —O—(C1-C3 alkyl), —O—(C1-C3 haloalkyl), and —S—(C1-C3 alkyl);
R2 and Rb are each independently selected from: —C(O)—N(R5)(R6), halogen, C(O)—O—R3, —C(O)—N(R7)—N(R5)(R6), —C(O)—N(R7)—N(R7)—C(O)—R4
and —C(O)—N(R7)—N(R7)—S(O)1-2—R4, a 6-18-membered aryl or a 5-18-membered heteroaryl;
R3 is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C18 carbocyclyl, C6-C18 aryl, 3-18-member heterocyclyl and 5-18-member heteroaryl;
R4 is selected from —N(H)(C3-C6 cycloalkyl), —N(C1-C4 alkyl)(C3-C6 cycloalkyl), —C1-C6 alkyl, —(C0-C4 alkylene)-C3-C18 carbocyclyl, —(C0-C4 alkylene)-3-18-member heterocyclyl, —(C0-C4 alkylene)-C6-C18 aryl, and —(C0-C4 alkylene)-5-18-member heteroaryl;
R5 and R6 are each independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C18 carbocyclyl, C6-C18 aryl, 3-18-member heterocyclyl and 5-18-member heteroaryl; or
R5 and R6 are taken together with the nitrogen atom to which they are commonly attached to form a 3-18-member heterocyclyl or 5-18-member heteroaryl; and
each R7 is independently hydrogen or C1-C4 alkyl;
n is 0, 1, 2, 3, 4 or 5;
wherein, unless otherwise designated, each alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, aryl, cycloalkyl, heterocyclyl and heteroaryl is optionally and independently substituted.

US Pat. No. 10,709,705

AMINOPYRIMIDINES AS ALK INHIBITORS

THE REGENTS OF THE UNIVER...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
R1a and R1b are independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-8 cycloalkyl;
R2a and R2b are independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-8 cycloalkyl;
R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C3-6 cycloalkyl, and C4-8 heterocyclo,
R4 is selected from the group consisting of C1-4 alkyl, and C3-6 cycloalkyl;
R5 is halo;
R6 is selected from the group consisting of C1-4 alkyl, and C3-6 cycloalkyl; and
R7 is selected from the group consisting of hydrogen, C1-4 alkyl, and C3-6 cycloalkyl,
with proviso that when R1a, R1b, R2a, and R2b are each hydrogen, then R3 is selected from the group consisting of C3-6 cycloalkyl and C4-8 heterocyclo.

US Pat. No. 10,709,703

2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES

Rigel Pharmaceuticals, In...

1. A compound according to Formula (I)or a salt thereof, wherein:one of R2 and R4 is a phenyl monosubstituted with (C1-C10) alkyl, —ORa optionally substituted with one Rb group, —O—C(O)ORa, —O—(CH2)m—C(O)ORa, —C(O)ORa, —O—(CH2)m—NRcRc, —O—C(O)NRcRc, —O—(CH2)m—C(O)NRcRc, —O—C(NH)NRcRc, —O—(CH2)m—C(NH)NRcRc or —NH—(CH2)m—NRcRc;
the other of R2 and R4 is a phenyl monosubstituted or disubstituted with R8;
R2 and R4 are different;
R5 is fluoro, —CN, or (C1-C6) alkyl optionally substituted with one or more halogen;
each R8 is independently selected from the group consisting of Rb, Ra substituted with one or more of the same or different Ra or Rb and —ORa substituted with one or more of the same or different Ra or Rb;
each Ra is independently selected from the group consisting of H, (C1-C6) alkyl and (C3-C8) cycloalkyl;
each Rb is independently selected from the group consisting of ?O, —ORd, —OCF3, —SRd, —NRcRc, halogen, —CF3, —CN, —NO2, —N3, —S(O)Rd, —S(O)2Rd, —S(O)2ORd, —S(O)NRcRc, —S(O)2NRcRc, —OS(O)Rd, —OS(O)2Rd, —OS(O)2ORd, —OS(O)2NRcRc, —C(O)Rd, —C(O)ORd, —C(O)NRcRc, —C(NH)NRcRc, —C(NRa)NRcRc, —C(NOH)Ra, —C(NOH)NRcRc, —OC(O)Rd, —OC(O)ORd and —OC(O)NRcRc;
each Rc is independently Ra or, alternatively, two Rc are taken together with the nitrogen atom to which they are bonded to form a 5 to 8-membered cycloheteroalkyl or heteroaryl;
each Rd is independently Ra; and
each m is independently an integer from 1 to 3.

US Pat. No. 10,709,699

PYRIDONE DERIVATIVE PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREOF

Jiangsu Hengrui Medicine ...

1. An oral solid pharmaceutical composition, comprising 2-((2-fluoro-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridin-3-yl)oxy)-6-oxo-1,6-dihydropyridine-3-carboxamide or a pharmaceutically acceptable salt thereof, and hydroxypropyl methylcellulose, wherein the pharmaceutical composition has a content of 0.01-10% by weight of 2-((2-fluoro-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridin-3-yl)oxy)-6-oxo-1,6-dihydropyridine-3-carboxamide or the pharmaceutically acceptable salt thereof, relative to a weight of the pharmaceutical composition, the hydroxypropyl methylcellulose is present in an amount of 1.5-3% by weight, relative to the weight of the pharmaceutical composition, and the pharmaceutical composition has a dissolution rate in 30 minutes greater than or equal to 85%, according to the dissolution test carried out using pH 6.8 phosphate buffer.

US Pat. No. 10,709,696

THERAPEUTIC AGENTS FOR TREATING DISEASES ASSOCIATED WITH CHRONIC INFLAMMATION AND SCREENING METHOD

King Faisal University, ...

1. A method of treating multiple sclerosis, comprising:administering to a subject in need thereof an effective amount of an Arid5a inhibitor, wherein the Arid5a inhibitor comprises a compound having the formula
or a pharmaceutically acceptable salt thereof, wherein the Arid5a inhibitor interacts with a target domain of Arid5a.

US Pat. No. 10,709,695

COMPOUNDS AS REARRANGED DURING TRANSFECTION (RET) INHIBITORS

GLAXOSMITHKLINE INTELLECT...

1. A method of treating a disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a compound which is N-(2-(dimethylamino)ethyl)-3-(2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)acetamido)-5-(trifluoromethyl)benzamide, represented by Formula (I):or a pharmaceutically acceptable salt thereof;wherein said disease or condition is selected from irritable bowel syndrome (IBS), pain associated with IBS, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, and proliferative diseases.

US Pat. No. 10,709,693

THERAPEUTIC USE OF TROMETHAMINE SALT OF L-AMPICILLINE IN HEMATOPOIESIS, IMMUNO-ONCOLOGY THERAPY, AND REGULATION OF LIPOPROTEIN AND APOLIPOPROTEIN LEVELS

Alpha-1 Biologics, LLC, ...

1. A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of the L-isomer of a ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum wherein said ?-lactam has substantially no bactericidal activity and wherein the ?-lactam is a tromethamine salt of L-ampicillin.

US Pat. No. 10,709,692

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK1)

Denali Therapeutics Inc.,...

1. A compound having the following structure (Xa):
or a pharmaceutically acceptable salt, prodrug, stereoisomer or a mixture of stereoisomers thereof, wherein:
A is —C(?O)—, —S(?O)—, —S(?O)2— or —S(?O)(?NH)—;
R1 is —NR5R6, C1-6 alkyl, C3-6 alkoxy, C3-10 cycloalkyl, heterocyclyl or heteroaryl;
R2 is aryl or heteroaryl;
R3 is hydrogen, deuterium, C1-6 alkyl or C3-10 cycloalkyl;
R3? is hydrogen or deuterium;
R4 is hydrogen, halo, C1-6 alkyl or C3-10 cycloalkyl;
R5 and R6 are each independently H, C1-6 alkyl, C3-10 cycloalkyl, aryl, heteroaryl or heterocyclyl,
wherein each C1-6 alkyl, C3-6 alkoxy, C3-C10 cycloalkyl, heterocyclyl, heteroaryl and aryl group of R1, R2, R3, R3?, R4, R5 and R6 is optionally substituted with one, two or three R10;
R10 in each instance is independently deuterium, halo, hydroxy, cyano, nitro, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(?O)R11, —C(?O)OR11, —C(?O)NR11R11, —S(—O)R11, —S(—O)2R11, —NR11R11, —NR11C(?O)R11 or —NR11C(?O)OR11;
wherein the C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, heterocyclyl, aryl and heteroaryl of R10 are optionally substituted with one, two or three substituents independently selected from halo, hydroxy, cyano, amino, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, heterocyclyl, aryl or heteroaryl; and
R11 in each instance is independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, heterocyclyl, heteroaryl or aryl;
wherein the C3-10 cycloalkyl, heterocyclyl, heteroaryl or aryl of R11 is optionally substituted with one, two or three C1-6 alkyl;
provided the compound is not ethyl 3-phenylisoxazolidine-2-carboxylate, benzyl 3-(4-amino-2-oxopyrimidin-1 (2H)-yl)isoxazolidine-2-carboxylate, 2-(methyl sulfonyl)-3-phenyl-isoxazolidine, tert-butyl 5-benzyl-3-phenylisoxazolidine-2-carboxylate, tert-butyl 5-(naphthalen-2-ylmethyl)-3-phenylisoxazolidine-2-carboxylate, tert-butyl 5-([1,1?-biphenyl]-4-ylmethyl)-3-phenylisoxazolidine-2-carboxylate or 2,2-dimethyl-1-(3-phenylisoxazolidin-2-yl)butan-1-one or 2,2-dimethyl-1-(3-phenylisoxazolidin-2-yl)but-3-en-1-one.

US Pat. No. 10,709,691

PHARMACEUTICAL DOSAGE FORMS

RECORDATI AG, Baar (CH)

1. A method of treating Cushing's disease or Cushing's syndrome with a pharmaceutical dosage form for oral administration comprising: (a) a drug substance 4-[(5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]3-fluorobenzonitrile as defined by formula (1)
or any pharmaceutically acceptable salt thereof, and (b) 70% to 95% by weight of microcrystalline cellulose based on the total weight of said pharmaceutical dosage form.

US Pat. No. 10,709,688

AGENT FOR TREATING SYNUCLEINOPATHY

Tohoku University, Miyag...

9. A compound represented by formula (Ib):
wherein R1a, R1b, R1c and R1d are independently selected from a hydrogen atom, C1-6 alkyl, C1-6 alkoxy, and a halogen atom;
R2a is selected from C1-6 alkyl, and a halogen atom;
R3a is a hydrogen atom or a halogen atom; and
R6 is selected from a hydrogen atom, and C1-6 alkyl,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,709,686

METHODS FOR TREATING PULMONARY FIBROSIS

DAVID WEINSTEIN CONSULTIN...

1. A method of treating idiopathic pulmonary fibrosis comprising administering to a patient in need thereof an effective amount of a composition comprising a compound of formula (I)and cyclosporine A.

US Pat. No. 10,709,683

LIQUID PHARMACEUTICAL COMPOSITIONS COMPRISING SGLT-2 INHIBITORS

1. An aqueous liquid pharmaceutical composition comprising at least one SGLT-2 inhibitor and one or more polar organic solvents, wherein the one or more polar organic solvents is selected from the group consisting of ethanol, propane-1,2-diol (propylene glycol), propane-1,2,3-triol (glycerol), and mixtures thereof, and the at least one SGLT-2 inhibitor comprises 1-cyano-2-(4-cyclopropyl-benzyl)-4-(?-D-glucopyranos-1-yl)-benzene according to formula (I):
wherein each of the one or more polar organic solvents is provided in an amount such that the liquid pharmaceutical composition as a whole is characterized by a Log P-Parameter of less than zero and equal to or greater than ?2.0.

US Pat. No. 10,709,682

TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM

Otolanum AG, Zug (CH)

1. A method for treating tinnitus in a subject in need thereof comprising systemically administering to the subject an oral pharmaceutical composition comprising a therapeutically effective amount of a compound, wherein the compound is:a compound according to formula II or formula III below:

or an isomer or enantiomer thereof,
or a pharmaceutically acceptable salt, solvate, tautomer or hydrate thereof, wherein
R1 is not present, H, O or S;
R2 is not present, H or when R1 is O or S, R2 is selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, alkylaminodialkyl, alkylcarbonylaminodialkyl, alkyloxycarbonylalkyl, alkylcarbonyloxyalkyl, alkylaldehyde, alkylketoalkyl, alkylamide, alkarylamide, arylamide, an alkylammonium group, alkylcarboxylic acid, alkylheteroaryl, alkylhydroxy, a biocompatible polymer such as alkyloxy(polyalkyloxy)alkylhydroxyl, a polyethylene glycol (PEG), a polyethylene glycol ester (PEG ester) and a polyethylene glycol ether (PEG ether), methyloxyalkyl, methyloxyalkaryl, methylthioalkyl and methylthioalkaryl, unsubstituted or substituted, and when R1 is not present, R2 is selected from the group consisting of hydrogen, N,N-dialkylamino, N,N-dialkarylamino, N,N-diarylamino, N-alkyl-N-alkarylamino, N-alkyl-N-arylamino, N-alkaryl-N-arylamino, unsubstituted or substituted;
R3 is selected from the group consisting of aryl, halo, hydroxy, alkoxy, and aryloxy, unsubstituted or substituted; and
R4 and R5 are each independently selected from the group consisting, of hydrogen, alkylaminodialkyl, carbonylalkyl, carbonylalkaryl, carbonylaryl, and salts thereof such as sodium, potassium, calcium, ammonium, trialkylarylammonium and tetraalkylammonium salts.

US Pat. No. 10,709,681

BIOLOGICALLY ACTIVE CANNABIDIOL ANALOGS

UNIVERSITY OF MISSISSIPPI...

1. A biologically active cannabidiol analog of the formula Iwherein one of R1 or R2 is H and the other is an amino acid ester amide or both R1 and R2 are an amino acid ester amide; or one of R1 or R2 is the amino acid ester amide and the other R1 or R2 is the ester residue of a dicarboxylic acid or dicarboxylic acid halide; wherein the amino acid ester amide comprises an amino acid linked to one or both of the hydroxyl groups of cannabidiol through an ester linkage and a dicarboxylic acid or dicarboxylic acid halide to the amino group of the amino acid in an amide linkage, wherein the amino acid is one of Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamine, Glutamic Acid, Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine and Valine, and a pharmaceutically acceptable salt thereof.

US Pat. No. 10,709,678

METHODS OF REDUCING RISK OF CARDIOVASCULAR DISEASE

NeuroBo Pharmaceuticals, ...

1. A method of decreasing a patient's risk for developing coronary heart disease or having a recurrent cardiovascular event, comprising administering to the patient an effective amount of the compound:
or an ester, or a salt, or a hydrate thereof,wherein the patient is on a stable dose of statin and requires additional lowering of LDL-C.

US Pat. No. 10,709,677

THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

INFLECTIS BIOSCIENCE, Na...

1. A method for treating a disorder selected from the group consisting of leukodystrophies, inflammatory conditions, cystic fibrosis and oculo-pharyngeal muscular dystrophy (OPMD), wherein the inflammatory conditions are selected from the group consisting of sepsis and systemic inflammatory response syndrome (SIRS), comprising administering to a patient in need thereof, a compound of formula (I), or a pharmaceutically acceptable salt thereof,
wherein:
R1 is alkyl, O-alkyl, Cl, F or Br;
R2 is H or F;
R3 is H or alkyl;
R4 is H or C(O)R6;
R5 is H;
or R4 and R5 are linked to form a 5 to 6 membered saturated or unsaturated heterocyclic group optionally comprising 1 or 2 heteroatoms such as N, in addition to the N atoms to which R4 and R5 are bound, and where said heterocyclic group is optionally substituted with one or more R10 groups;
R6 is selected from the group consisting of R7, OR7 and NR8R9;
R7, R8 and R9 are each independently selected from the group consisting of alkyl, cycloalkyl, aralkyl, cycloalkenyl, heterocyclyl and aryl, each of which is optionally substituted with one or more R10 groups;
each R10 is independently selected from the group consisting of halogen, OH, ?O, CN, COO-alkyl, aralkyl, SO2-alkyl, SO2-aryl, COOH, CO-alkyl, CO-aryl, NH2, NH-alkyl, N(alkyl)2, CF3, alkyl and alkoxy;
X and Z are each independently CR11, and Y is CR11 or N; and
R11 is H, alkyl or F.

US Pat. No. 10,709,669

MICRORESERVOIR SYSTEM BASED ON POLYSILOXANES AND AMBIPHILIC SOLVENTS

LTS LOHMANN Therape-Syste...

1. A transdermal therapeutic system consisting essentially of:an active substance impermeable backing layer comprising polyethylene terephthalate;
at least one polymer layer with microreservoirs present therein;
an optional self-adhesive layer adjacent to the at least one polymer layer for anchoring the therapeutic system to skin;
an optional self-adhesive, microreservoir-free layer adjacent to the at least one polymer layer for anchoring the therapeutic system to the backing layer;
at least one active substance selected from the group consisting of estradiol hemihydrate, and testosterone, wherein the active substance is dissolved in a solvent in said microreservoirs; and
a protective layer for removal before use;wherein:a) at least 70% by weight of the polymer in the polymer layer consists of at least one amine-resistant polysiloxane that is soluble in lipophilic solvents;
b) the microreservoirs are essentially free of water and wherein the solvent in which the active substance is dissolved, consists of at least 50% by weight of an amphiphilic solvent selected from the group consisting of diethylene glycol monoethyl ether, diethylene glycol dimethyl ether, tetrahydrofurfuryl alcohol, dipropylene glycol, and mixtures thereof; and wherein
c) the amphiphilic solvent is soluble in polysiloxanes to the extent of not more than about 20% by weight.

US Pat. No. 10,709,666

CARRIER PARTICLES FOR DRY POWDER FORMULATIONS FOR INHALATION

CHIESI FARMACEUTICI S.P.A...

1. A process for preparing a granule of a physiologically acceptable excipient to be used as a carrier for dry powder formulations for inhalation, said granule having a mass diameter of from 200 to 800 micrometers and having on its surface pores with a perimeter from 70 to 300 micrometers and a diameter from 30 to 100 micrometers, a specific surface area of 0.13 to 0.20 m2/g, and a loading capacity equal or higher than 35%, wherein said physiologically acceptable excipient is selected from the group consisting of lactose, mannitol, trehalose, dextran, glucose, and mixtures thereof; wherein said granule has a friability of less than 3%, said process comprising the following steps:(i) selecting particles of a physiologically acceptable excipient having a starting median volume diameter of at least 100 micrometers;
(ii) preparing an oversaturated aqueous solution comprising part of said physiologically acceptable excipient having a concentration in water of from 30 to 50% w/v;
(iii) wetting the remaining part of said physiologically acceptable excipient with 10 to 25% w/w of said aqueous solution obtained in (ii), to obtain a mixture;
(iv) stirring said mixture obtain a slurry;
(v) forcing said slurry through a sieve, to obtain a wet mass; and
(vi) drying said wet mass to obtain said granules.

US Pat. No. 10,709,665

ZINC MELOXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND PROCESSES FOR MAKING THE SAME

Pacira Pharmaceuticals, I...

1. A formulation of multivesicular liposomes (MVLs) having multiple nonconcentric internal compartments, comprising:a zinc meloxicam complex having the formula Zn(MLX)2, and one or more pH adjusting agents encapsulated in a first aqueous phase of the multivesicular liposomes; and
lipid components comprising at least one amphipathic lipid selected from phosphatidyl choline or salts thereof, phosphatidyl glycerol or salts thereof, or combinations thereof, and at least one neutral lipid;
wherein at least a portion of the zinc meloxicam complex forms a suspension of microparticles in the first aqueous phase.

US Pat. No. 10,709,664

NANOLIPOGEL COMPRISING A POLYMERIC MATRIX AND A LIPID SHELL

Yale University, New Hav...

1. A nanolipogel comprising a polymeric matrix core, and a lipid shell;wherein the nanolipogel is loaded with an anti-inflammatory cytokine and a growth factor each dispersed within the polymeric matrix, dispersed in the lipid shell, and/or bound to the lipid shell.

US Pat. No. 10,709,663

MUPIROCIN CREAM IN PUMP DEVICE

GLENMARK PHARMACEUTICALS,...

1. A mupirocin cream dispensing system comprisinga. a topical cream composition comprising:
i. 2.365% by weight of mupirocin or a salt thereof;
ii. 1% by weight of benzyl alcohol;
iii. 50.6% by weight of a mineral oil;
iv. 0.5% by weight of phenoxyethanol;
v. 0.215% by weight of xanthan gum;
vi. 6% by weight of a polyoxyethylene ether or ester surfactant;
vii. 5% by weight of glyceryl monostearate; and
viii. water; and
b. a pump device comprising a dispensing head having an internal fluid passage formed therein which terminates at an outlet; an actuator; a valve; an inner actuator; a reduction plug; and a bellow; where the internal fluid passage is further defined within the actuator, the inner actuator, the reduction plug, the bellow, and the valve; and where: the actuator resides over and about an outer circumference of the inner actuator; the reduction plug resides within the inner actuator, and has an outer upper lip that abuts an inner upper shoulder of the inner actuator; a lower shoulder of the reduction plug abuts an upper rim of the bellow; and the reduction plug includes a stem extending axially, from the lower shoulder of the reduction plug, into the bellow;
wherein said pump device delivers a unit dose amount of about 300 to about 500 mg of topical cream composition per actuation.

US Pat. No. 10,709,643

TAMPER-PROOF PILL DISPENSING SYSTEM AND METHODS OF USE

1. A method for administering a pill dispensing system for managing the distribution of pills to a patient, the method comprising the steps of:implementing an at least one tamper-proof pill storage container that provides an at least one pill magazine positioned within a housing of the pill storage container and configured for storing and selectively dispensing a plurality of pills through a pill outlet provided by the housing;
implementing a patient application residing in memory on an at least one patient device under the control of the patient, the patient application in selective communication with the at least one pill storage container;
implementing an at least one monitoring device in selective communication with the patient application, the at least one monitoring device configured for assisting the patient application with monitoring an at least one vital of the patient;
obtaining from the patient at least one of a security code, via the patient application, and an at least one biometric marker associated with the patient, via an at least one biometric sensor;
registering, via the patient application, a prescription associated with the pills contained within the at least one pill magazine of the at least one pill storage container, said prescription including a dosage interval and a dosage quantity;
upon the patient application determining that a dosage of the pills is available for the patient, based on the associated dosage interval:
obtaining from the patient at least one of the security code and the at least one biometric marker; and
upon the patient application authenticating at least one of the security code and the at least one biometric marker:
distributing a quantity of pills equal to the associated dosage quantity; and
upon said pill storage container distributing the pills to the patient, scheduling, via the patient application, a future dosage of the pills based on the associated dosage interval;
upon the patient application determining that the at least one monitored vital is abnormal:
notifying the patient via the at least one patient device;
upon the patient application failing to receive a response from the patient within a pre-defined period of time, automatically alerting, via the patient application, local emergency personnel; and
upon the at least one pill storage container being tampered with, said pill storage container automatically releasing an at least one tamper-proof substance within said pill storage container in order to render the pills inert, inactive or intolerable.

US Pat. No. 10,709,642

SMART PACK SYSTEM FOR MEDICINES

TOTUSRX INC., Lougmont, ...

1. A method of automatically dispensing medication to an authorized user of an automated dispenser comprising:packaging said medication in a blister package having processing, storage and communication circuitry disposed on an overlay of said blister package that contains data that identifies said medication packaged in said blister package;
communicating said data identifying said medication from said blister package to said automated dispenser;
receiving prescription data for a patient at said automated dispenser;
programming said blister package with said prescription data;
generating a patient label identifying said patient for said medication and instructions for use of said medication;
applying said patient label to said blister package;
verifying that a user of said automated dispenser is said authorization user of said automated dispenser;
dispensing said medication to said authorized user.

US Pat. No. 10,709,641

RHYTHMIC PILL CRUSHER

SONG YANG, Minhang Distr...

1. A rhythmic pill crusher, including:a crushing cover including a cylindrical boss, wherein a plurality of first threads formed on a first wall of the crushing cover and around a column portion of the cylindrical boss, and the cylindrical boss including a first crushing portion formed on a bottom face, wherein the first wall is distant from the column portion of the cylindrical boss; and
a supporting platform including a cylindrical recess for receiving the cylindrical boss and a plurality of second threads formed, corresponding to the first threads, on a second wall of the supporting platform, and a second crushing portion formed, corresponding to the first crushing portion, on bottom of the cylindrical recess, the first crushing portion, the second crushing portion and an inner wall of the cylindrical recess forming a crushing chamber;
wherein the first threads and the second threads each include a plurality of ridges and a groove located between two adjacent ridges and the ridges of the first threads and the second threads is accommodated in the groove of the other first threads and the second threads; and
wherein a groove width of the first threads and the second threads is larger than a ridge width of the first threads and the second threads such that the ridges of the first threads and second threads vertically move in the groove of the other of the first threads and the second threads.

US Pat. No. 10,709,639

TABLET PRINTING APPARATUS AND TABLET PRINTING METHOD

SHIBAURA MECHATRONICS COR...

1. A tablet printing apparatus, comprising:a supplier configured to supply a tablet;
a conveyor belt configured to convey the tablet supplied by the supplier;
a print head configured to perform printing on the tablet conveyed by the conveyor belt;
a belt-position detector configured to detect a position of the conveyor belt in a crossing direction, which crosses conveying direction of the tablet in a horizontal plane; and
a controller, wherein
the conveyor belt includes a plurality of holes arranged in a row along the conveying direction of the tablet, each configured to hold the tablet,
the belt-position detector includes:
an imaging device configured to capture an image of two or more of the holes; and
an image processing device configured to detect the position of the conveyor belt in the crossing direction based on the image captured by the imaging device, and
the controller is configured to:
cause the imaging device to capture the image in a state where the supplier stops supplying the tablet;
cause the imaging processing device to detect the position of the conveyor belt based on the image captured by the imaging device in a state where the supplier stops supplying the tablet;
determine whether the position of the conveyor belt detected by the image processing device is within an allowable range; and
cause the supplier to start the supply of the tablet when it is determined that the position of the conveyor belt detected by the image processing device is within the allowable range.

US Pat. No. 10,709,638

PROTECTING BODY FOR A FLEXIBLE POUCH, SYSTEM FOR CONTAINING A BIOPHARMACEUTICAL FLUID AND METHODS FOR USING SUCH A SYSTEM

SARTORIUS STEDIM NORTH AM...

1. A protecting body for a flexible pouch specially designed to contain a biopharmaceutical fluid, the protecting body comprising:a flexible pouch with at least one opening on a peripheral side of the flexible pouch, the flexible pouch having an interior volume delimited by a fluid receiving part of the pouch for containing the biopharmaceutical fluid;
at least one port received in the opening of the flexible pouch, the at least one port provided for filling the flexible pouch with the biopharmaceutical fluid,
two substantially planar plates which respectively form a lower surface and an upper surface and which are fixed to each other in an assembled state, the two plates being made separately from each other prior to being assembled into the assembled state,
wherein the two plates delimit an expansible volume closed between a covering region of one of the two plates and a covering region of the other one of the two plates, each covering region includes a central region of the plate,
wherein the two plates are more rigid than the flexible pouch,
wherein the two plates are two constraining plates that sandwich the flexible pouch and completely cover the fluid receiving part of the pouch for constraining the flexible pouch, the protecting body being planar in the assembled state for a non-filled state of the flexible pouch, and
an attachment system, the two plates being fixed peripherally to each other by the attachment system, a main plane of the protecting body intersecting the attachment system, and
wherein each of the two plates is flexible enough to allow, during filling of the flexible pouch from the non-filled state to a filled state, the two plates to curve under pressure of the flexible pouch being filled and become curved to delimit the expansible volume with a distance between the covering region of each of the two plates progressively increasing toward the center region of the covering region of each plate, in order that in the filled state a thickness of the flexible pouch in a central area at the center region of the covering region of each plate is greater than a thickness of the flexible pouch in a circumferential area of the protecting body.

US Pat. No. 10,709,637

VENOUS BAG CLAMPING MECHANISM

Sorin Group Italia S.r.l....

1. A soft shell venous reservoir for use in an extracorporeal circulation system of the type including:a blood reservoir;
the blood reservoir comprising at least a first layer of flexible material and a second layer, the first and second layers sealed together to define a bag compartment capable of receiving fluid, the bag compartment having openings defining a single inlet port, an exit port, and an air vent;
a flexible tube coupled to the single inlet port and in fluid communication with the single inlet port;
a clamp situated at the flexible tube, such that a healthcare worker can engage the clamp to control the fluid flow rate through the flexible tube and the single inlet port;
a rigid back plate containing securements to couple the blood reservoir, the single inlet port, and the flexible tube to the rigid back plate, the rigid back plate comprising an empty area configured for positioning the clamp at the flexible tube; and
a fluid line connector configured to combine multiple inlet fluid lines in fluid communication with the single inlet port, the flexible tube being located in between the fluid line connector and the single inlet port,
wherein the clamp is configured to be movable to positions upstream and downstream from the fluid line connector, such that the healthcare worker can engage the clamp to restrict blood flow into the reservoir.

US Pat. No. 10,709,636

SYSTEM FOR GASTROINTESTINAL ENGINEERING TO RESTORE NORMAL YOUTHFUL BODILY FUNCTIONS

Franklin R. Lacy, Marco ...

1. A system for reversing atrophy of the function of the gastrointestinal tract, comprising:a probe assembly adapted for insertion into the gastrointestinal tract in the human body by insertion of the article into the rectum, the probe assembly having a forward tip end portion thereof which vibrates when the probe assembly is activated by a vibration system at a selected frequency and amplitude of 20-50 Hz and 0.02-0.13 inches, wherein the vibrations are directed to and stimulate the nerve endings or the nerve endings and muscles along the gastrointestinal tract, wherein the probe assembly includes a flexible shaft with the forward tip end and a rear handle end, wherein the flexible shaft is configured such that the forward tip end extends through the colon to the ileocecal valve, with the rear handle end remaining outside of the body, and wherein the forward tip end is bulbous in the form of a bulb and has a diameter such that it can extend into the rectum and the gastrointestinal tract, wherein the probe assembly includes a plurality of separate vibrating elements in addition to the forward tip end positioned at separate spaced points along the length of the flexible shaft for stimulating the nerve endings or the nerve endings and muscles at selected separate spaced points along the length of the gastrointestinal tract when the probe assembly is positioned in the gastrointestinal tract.

US Pat. No. 10,709,635

STIMULATION DEVICE

NOVOLUTO GMBH, Berlin (D...

1. A stimulation device comprising:a chamber having a flexible wall;
a drive unit in physical communication with the flexible wall to cause at least a portion of the flexible wall to deflect in opposing directions, thereby resulting in a changing volume of the chamber, the changing volume of the chamber resulting in modulated positive and negative pressures with respect to an ambient pressure;
an opening configured to sealingly engage a portion of a body of a user including a clitoris, the modulated positive and negative pressures to be applied to the portion of the body via the opening, the opening being a sole opening of the chamber to an exterior of the stimulation device;
a control device configured to receive input from the user and control the drive unit to cause the at least the portion of the flexible wall to deflect to create the modulated positive and negative pressures based on modulated frequencies; and
a housing enclosing the drive unit and the control device.

US Pat. No. 10,709,634

PIN-SHAPED STIMULATION DEVICE

NOVOLUTO GmbH, Berlin (D...

1. A stimulation device for a clitoris, comprising:a housing;
a pressure field generation device having a drive unit which generates a pressure field from temporally alternating negative and positive pressures of a medium in a hollow space; and
a control device which controls the drive unit;
wherein:
the housing has a longitudinal axis, which extends from a front end of the housing up to a back end of the housing,
an opening for placing over the clitoris is provided in the front end of the housing with a center of the longitudinal axis passing through an opening plane of the opening, wherein the opening plane is defined by outer edges of the opening,
the hollow space is arranged inside the housing and is connected to the opening of the housing,
the pressure field generation device comprises a flexible wall which is configured to be displaced by the drive unit, and
a direction of the displacement of the flexible wall is provided by the drive unit at an angle relative to an alignment axis that is defined by an alignment of currents of the medium in the hollow space when generating the positive pressures.

US Pat. No. 10,709,633

EXOSKELETON SUPPORT MECHANISM FOR A MEDICAL EXOSKELETON

The Regents of the Univer...

1. A coupling device, configurable to couple a walker to a torso orthosis, which is configurable to couple to an upper body of a person, said coupling device comprising:an orthosis coupling member, configurable to be coupled to said torso orthosis;
a walker coupling member, configurable to be coupled to said walker; and
a mechanism, comprising a first end and a second end and coupled to the orthosis coupling member from the first end and to the walker coupling member from the second end,
wherein said mechanism is configured to constrain said orthosis coupling member to move and rotate relative to the walker coupling member in a free plane and to allow said torso orthosis and said upper body of the person to move and rotate laterally, and
wherein when said torso orthosis is worn by the person and said coupling mechanism is coupled to both said walker and said torso orthosis, and when said person is walking in a forward direction, said mechanism forces said walker coupling member and said orthosis coupling member to move along said forward direction together, and allows said orthosis coupling member to move and rotate laterally in said free plane for weight shifting during walking.

US Pat. No. 10,709,632

PEDOMETER, WALKING ASSIST DEVICE AND PEDOMETRIC COMPUTER PROGRAM PRODUCT

Honda Motor Co., Ltd., T...

1. A pedometer, comprising:a clock for obtaining time information associated with a walking movement of a user;
a switch for initiating and terminating a measurement operation of the pedometer;
a state variable detection unit for detecting a state variable indicating the walking movement of the user;
a walking step determination unit for determining each walking step of the user from an output of the state variable detection unit;
a walking information storage unit for incrementing a step count each time a walking step is determined by the walking step determination unit and storing the incremented step count and the associated time information obtained by the clock; and
a walking step count computation unit for computing a walking step count of the user from a time point of initiating the measurement operation to a time point of terminating the measurement operation to a decimal part according to the step count and the associated time information stored in the walking information storage unit,
wherein the walking step count computation unit is configured to compute a walking step count at the time point of terminating the measurement operation as a sum of the step count stored in the walking information storage unit and a ratio of a time interval between an end of a last full walking step and the time point of terminating the measurement operation to a prescribed walking period of the user.

US Pat. No. 10,709,631

COMPRESSION GARMENT FOR NEUROLOGICAL AND CIRCULATORY DISORDERS

MEDI USA, L.P., Whitsett...

1. A compression garment for a neurological disorder, the garment comprising:a body portion operable to wrap around a foot;
a pad operatively coupled to an inner surface of the body portion in a predetermined position, the pad comprising an outward protrusion;
a stretchable guide sleeve dimensioned to wrap together with the body portion around the foot, the pad being removably retained between the body portion and the guide sleeve; and
a first tensioning band operatively coupled to first and second locations of an outer surface of the body portion, the first tensioning band operable to secure opposing first and second portions of the inner surface of the body portion in order to secure the outward protrusion of the pad against the foot in the predetermined position.

US Pat. No. 10,709,630

SPINE TABLE POSITIONER PAD WITH PRESSURE SENSING AND COOLING FEATURES

Allen Medical Systems, In...

1. A method of sensing a pressure applied by a support pad, the method comprising:positioning a support pad beneath a person, the support pad comprising a fluid-filled bladder containing a fluid comprising an oil, water, or other stable aqueous composition comprising one or more chambers, a support cushion, the fluid-filled bladder positioned between the person and the support cushion;
sensing a fluid pressure via tubing within each of the one or more chambers of the fluid-filled bladder based on an amount of the oil, water, or other stable aqueous composition entering the tubing with an electronic pressure sensor positioned external to the support pad; and
adjusting a position of the support pad horizontally along a frame relative to the person responsive to the fluid pressure.

US Pat. No. 10,709,629

INFANT WARMING DEVICE WITH IN BED PATIENT SUPPORT POWER, SIGNAL, CONTROL, DATA, AND COMMUNICATIONS

1. An infant care device, comprising:a wheeled base,
a vertical column coupled to the wheeled base, the vertical column housing a main controller,
a patient bed assembly including electronic hardware for use in caring for a patient,
a rotatable patient support mechanism coupled to the patient bed assembly, the patient support mechanism including electronics for providing at least one of a power, signal, control, data, and communication line for the electronic hardware of the patient bed assembly, and
a cable connection coupled to the at least one of the power, signal, control, data, and communication line, the cable connection including a slip ring located in the patient support mechanism, and cables connecting the slip ring to the main controller,
wherein the patient support mechanism is operable to rotate the patient bed assembly relative to the wheeled base, and the slip ring is configured to permit rotation of the patient bed assembly without tangling the cables and the at least one of a power, signal, control, data, and communication line.

US Pat. No. 10,709,628

METHOD AND APPARATUS FOR EXTRACORPOREAL SUPPORT OF PREMATURE FETUS

1. A fetal chamber configured for use in a system configured to enclose a human fetus and maintain the fetus during maturation, the fetal chamber comprising:a first portion having a rigid first frame defining a first perimeter lip defining a first opening for the first portion and a flexible wall connected to the first frame and a second portion having a rigid second frame defining a second perimeter lip defining a second opening for the second portion, the fetal chamber configured to hold a volume of synthetic amniotic liquid in an interior space of the fetal chamber sufficient to immerse the human fetus in the synthetic amniotic liquid,
wherein the fetal chamber further comprises an amniotic inlet port for receiving a flow of synthetic amniotic liquid into the fetal chamber and an amniotic outlet port for discharging a flow of synthetic amniotic liquid from the fetal chamber;
wherein 1) the fetal chamber defines a closed configuration in which a plurality of latches secures the first and second frames together to form a liquid-tight seal between the first and second lips and wherein in the closed configuration the interior space defines a volume that is variable, the flexible wall is configured to expand thereby increasing the volume, and the flexible wall is configured to contract thereby decreasing the volume, and 2) the fetal chamber further defines an open configuration in which the first and second lips are separated to accommodate entry of the human fetus into the interior space.

US Pat. No. 10,709,627

USE OF HIGH PRESSURE LOW VOLUME AIR CONVERSION TO LOW PRESSURE HIGH VOLUME AIR TO POWER PATIENT TRANSPORT DEVICES

Qfix Systems, LLC, Avond...

1. A system for at least one of patient support, patient imaging, patient therapeutic procedures with or without the use of instruments, and patient transport, the system comprising:a modality with a support surface configured to support a patient thereon;
a converter associated with the modality, the converter not comprising an electric blower, the converter being configured to receive relatively low-volume high-pressure air flow from a source of the relatively low-volume high-pressure air flow and to draw ambient air, and thereby to convert the relatively low-volume high-pressure air flow and the ambient air into relatively high-volume low-pressure air flow; and
an air flow device configured to receive the relatively high-volume low-pressure air flow from the converter and provide an air flow function to the modality using the relatively high-volume low-pressure air flow.