US Pat. No. 10,688,246

SPACE SAVING DRUG INJECTION DEVICE

Sanofi, Paris (FR)

1. An injection device for setting and dispensing a dose of a medicament, the injection device comprising:a cartridge containing the medicament and comprising a piston;
an elongate housing to accommodate the cartridge;
a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge,
a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section; and
a drive sleeve extending along a second axis angled relative to the first axis and having a wheel section or geared section to mesh with the wheel section or geared section of the drive member,
wherein a first radial distance between the first axis and the second axis at a distal end of the drive sleeve differs from a second radial distance between the first axis and the second axis at a proximal end of the drive sleeve,
wherein the cartridge extends along a third axis radially offset from and parallel to the second axis and is configured to be assembled inside the housing,
wherein the first axis and the third axis substantially overlap at a virtual crossing point and form a non-zero angle, and
wherein the virtual crossing point is located distally from a distal end of the piston rod.

US Pat. No. 10,688,245

PLUNGER FOR SYRINGE AND PRE-FILLED SYRINGE INCLUDING THE SAME

TERUMO KABUSHIKI KAISHA, ...

1. A plunger for a syringe that comprises a barrel, the plunger comprising:a gasket mounting portion located at a distal end of the plunger;
a disk positioned at a proximal end of the gasket mounting portion;
a shaft extending proximally from the disk, wherein the shaft comprises three or more slats extending proximally from the disk, wherein the three or more slats include a first slat, a second slat that is adjacent to the first slat, and a third slat that is adjacent to the second slat;
a pressing portion located at a proximal end of the shaft; and
a plunger inclination-prevention unit that is located at a distal end of the shaft and is configured to inhibit the plunger from inclining inside the barrel of the syringe, wherein the plunger inclination-prevention unit comprises a plurality of axially inclined plates, wherein each of the plurality of axially inclined plates has an outer edge positioned at or proximate to an outer edge of the disk, and wherein the plurality of axially inclined plates includes:
a first axially inclined plate that has a first end disposed on the disk, extends obliquely proximal with respect to a central axis of the shaft, and has a second end disposed on the second slat, and
a second axially inclined plate that has a first end disposed on the disk, extends obliquely proximal with respect to the central axis of the shaft, and has a second end disposed on the first slat,
wherein the first axially inclined plate intersects the second axially inclined plate.

US Pat. No. 10,688,244

MEDICAMENT DELIVERY DEVICE AND METHODS FOR DELIVERING DRUGS TO INFANTS AND CHILDREN

kaleo, Inc., Richmond, V...

1. A method, comprising:placing a distal end surface of a medical injector into contact with a target location of a patient, the medical injector including a housing, an energy storage member and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis, the medicament container coupled to a needle via a carrier, the carrier including a retention portion and defining a coupling volume, the retention portion of the carrier configured to retain a distal end portion of the medicament container in a first container position within the coupling volume, the distal end portion of the medicament container fluidically isolated from a proximal tip of the needle when the medicament container is in the first container position, the distal end portion of the medicament container configured to move to a second container position within the coupling volume in response to an actuation force, the distal end portion of the medicament container fluidically coupled to the proximal tip of the needle when the medicament container is in the second container position, the retention portion including an annular protrusion defining a bleed passageway from the coupling volume towards a proximal end portion of the carrier; and
actuating the medical injector after the placing such that the energy storage member produces the actuation force to move the needle from a first needle position to a second needle position, a distal tip of the needle extending from the distal end surface by a distance of at least 6.35 millimeters when the needle is in the second needle position, the actuation force further moving the medicament container from the first container position to the second container position, a portion of the actuation force exerted to expel the dose of epinephrine from the medicament container when the needle is in the second position.

US Pat. No. 10,688,243

CARTRIDGE INSERTION ASSEMBLY

1. A method of loading a cartridge containing a substance to be administered to a subject into an apparatus for administering the substance, the method comprising:moving a door of the apparatus into an open position thereof to expose a pathway within the apparatus;
inserting the cartridge into the pathway, the cartridge comprising a cartridge coupling element and a septum at an end opposite to the cartridge coupling element, the cartridge coupling element being connectable to a coupling element of an activation mechanism disposed in the apparatus and operative to cause the substance in the cartridge to be metered out; and
moving the door to a closed position, which couples a door coupling element with each of the cartridge coupling element and the activation mechanism coupling element, thereby coupling the cartridge coupling element with the activation mechanism coupling element.

US Pat. No. 10,688,242

HIGH FLOW RATE DUAL RESERVOIR PORT SYSTEM

AngioDynamics, Inc., Lat...

1. A method comprising:delivering a fluid through a port and a catheter, the port comprising:
a first reservoir comprising a first outlet lumen;
a second reservoir comprising a second outlet lumen;
wherein the first reservoir is configured to be larger than the second reservoir, and
wherein a first cross-sectional area of the first outlet lumen is greater than a second cross-sectional area of the second outlet lumen; and the catheter comprising:
a first catheter lumen and a second catheter lumen;
wherein the first catheter lumen has a greater cross-sectional area than the second catheter lumen;
aspirating the fluid through the first catheter lumen;
infusing the fluid through the second catheter lumen.

US Pat. No. 10,688,241

MULTI-MODE POWER SUPPLY SYSTEM FOR A PORTABLE INFUSION DEVICE

MEDTRUM TECHNOLOGIES INC....

1. A multi-mode power supply system for a portable infusion device, comprising:A Battery I, a Battery II, the Battery I is coupled with the Battery II, the Battery I is further coupled with a control unit, the Battery II is further coupled with a driving unit;
wherein,
the Battery I is able to constantly charge the Battery II constituting a charging circuit, configured to maintain the voltage of the Battery II at a certain level;
the Battery I powers the control unit independently constituting a power supply circuit A, configured to ensure the infusion control of the portable infusion device by the control unit;
the Battery II powers the driving unit independently constituting a power supply circuit B, configured to drive the drug infusion;
the power supply circuit A and the power supply circuit B are independent from each other;
the charging circuit adopts one of multiple charging modes depending on different drug infusion conditions.

US Pat. No. 10,688,240

NEEDLE CHANGING APPARATUS

Becton, Dickinson and Com...

1. A needle changing device for use on a medication delivery device, the needle changing device comprising:an engagement element that is configured to engage the medication delivery device and pierce a septum of the medication delivery device;
a needle holder connected to the engagement element, the needle holder having:
a needle changing septum having a reservoir, the reservoir being in continuous fluid communication with the engagement element; and
a plurality of needles configured to pierce the needle changing septum;
wherein when the needle holder is in a first position, the plurality of needles are disengaged from the reservoir of the needle changing septum, and when the needle holder is in a second position, one of the plurality of needles enters into fluid communication with the reservoir of the needle changing septum and is partially exposed outside the needle changing device for medicament delivery.

US Pat. No. 10,688,238

ANESTHESIA SYSTEM FOR CARDIOPULMONARY BYPASS MACHINE

GENERAL ELECTRIC COMPANY,...

16. A method for operating an anesthesia machine, comprising:flowing vaporized anesthetic agent from the anesthesia machine to an airway of a patient via an anesthesia breathing circuit; and
measuring an amount of vaporized anesthetic agent flowing from an outlet of an oxygenator of a cardiopulmonary bypass machine with the anesthesia machine.

US Pat. No. 10,688,237

APPARATUS AND METHOD FOR DETECTING VENOUS NEEDLE DISLODGEMENT

B. BRAUN AVITUM AG, Mels...

1. An apparatus for detecting an interruption of connection between a blood treatment apparatus and a patient blood circulation which can be connected to the blood treatment apparatus, the apparatus comprising:a blood supply line of an extracorporeal blood circulation, wherein the blood supply line is connected upstream of the blood treatment apparatus for delivering blood from the patient blood circulation to the blood treatment apparatus;
a blood discharge line of the extracorporeal blood circulation, wherein the blood discharge line is connected downstream of the blood treatment apparatus for returning blood from the blood treatment apparatus to the patient blood circulation;
a valve or clamp arranged on the blood discharge line, the valve or clamp configured to selectively assume a closed position in which the valve or clamp blocks blood flow through the extracorporeal blood circulation at the valve or clamp;
a pressure sensor configured to measure fluid pressure in the blood discharge line, the pressure sensor located at a position located between the valve or clamp and the patient blood circulation;
a blood pump arranged on the extracorporeal blood circulation, wherein the blood pump continues to pump blood from the patient blood circulation while the valve or clamp is in the closed position;
a collecting reservoir arranged on the extracorporeal blood circulation, wherein the collecting reservoir stores blood pumped from the blood pump while the valve or clamp is in the closed position; and
a control and evaluation unit configured to evaluate the fluid pressure or a fluid pressure curve based on the measured fluid pressure occurring while the valve or clamp is in the closed position to detect an interruption or disturbance of the connection between the blood treatment apparatus and the patient blood circulation;
wherein, while the valve or clamp is in the closed position, operation of the blood pump is terminated when the collecting reservoir is filled.

US Pat. No. 10,688,236

SYSTEMS AND METHODS FOR PERFORMING MEDICAL PROCEDURES INVOLVING ACCESSING THE LYMPHATIC SYSTEM

LXS, LLC, Palo Alto, CA ...

1. A method for harvesting one or more organs from a donor body, comprising:introducing a distal end of a tubular member into a vasculature of the donor body;
introducing the distal end of the tubular member into a thoracic duct of the donor body;
removing fluid from the thoracic duct via the tubular member to a location exterior to the donor body to control fluid accumulation within or around the one or more organs before removing the one or more organs from the donor body; and
removing the one or more organs from the donor body.

US Pat. No. 10,688,235

PERITONEAL DIALYSIS SYSTEMS, DEVICES, AND METHODS

NxStage Medical, Inc., L...

1. A system for performing peritoneal dialysis, the system comprising:a peritoneal catheter for infusing a fluid into an abdomen of a patient during a fill cycle and withdrawing the fluid from the abdomen of the patient during a drain cycle, the withdrawn fluid being a waste fluid;
a peritoneal fill line having a distal end and a proximal end opposite the distal end, the peritoneal catheter being connected at the distal end of the peritoneal fill line and the proximal end of the peritoneal fill line being connected to a fluid circuit switch;
the fluid circuit switch, wherein the fluid circuit switch selectively connects the peritoneal fill line at least to a source of the fluid and to a drain for receiving the waste fluid that has been withdrawn from the abdomen of the patient, wherein the fluid flows through the peritoneal fill line in a distal direction during the fill cycle in a proximal direction during the drain cycle;
a controller;
a distal pressure sensor at the distal end configured to apply a distal pressure signal to the controller, the distal pressure sensor being configured to permit measurement of pressure of the fluid flowing in the proximal direction and also in the distal direction; and
a proximal pressure sensor at the proximal end configured to apply a proximal pressure signal to the controller, the proximal pressure sensor being configured to permit measurement of pressure of the fluid flowing in the proximal direction and also in the distal direction, wherein
the controller is configured to detect a difference in pressures represented by the proximal pressure signal and the distal pressure signal during the fill cycle and during the drain cycle thereby to detect a condition where the difference in pressures exceeds a predefined threshold and to generate a first output based on the difference in pressures.

US Pat. No. 10,688,234

PERITONEAL DIALYSIS SYSTEMS, DEVICES, AND METHODS

NxStage Medical, Inc., L...

1. A method of performing a peritoneal dialysis treatment with a peritoneal dialysis treatment system, the method comprising:connecting a disposable unit to a source of water, said disposable unit including at least a first container holding a sterile first concentrate containing at least an osmotic agent, a second container holding a sterile second concentrate containing electrolytes, an empty sterile mixing container, and a tubing set with a pre-attached peritoneal fill/drain line;
receiving a prescription command by a controller of the peritoneal dialysis treatment system, the prescription command including at least a fill volume and a desired final concentration of the osmotic agent in a mixture of the water and at least the first concentrate to be used as a treatment fluid for a current fill cycle under said peritoneal dialysis treatment;
pumping a first volume of water from the source of water into the mixing container, wherein the first volume is based on at least the prescription command;
using the controller, pumping a quantity of the first concentrate into the mixing container, the quantity, based on an expected concentration of the first concentrate, being at least sufficient to achieve the desired final concentration based on the fill volume;
mixing all contents of the mixing container after said pumping the quantity of the first concentrate;
after said mixing, adding water or the first concentrate to the mixing container to generate the treatment fluid in the mixing container; and
flowing the treatment fluid from the mixing container to a patient.

US Pat. No. 10,688,233

METHOD AND SYSTEM FOR THE AUTOMATED PROCESSING OF BIOLOGICAL FLUID DURING LOW LEVEL ALERT CONDITION

Fenwal, Inc., Lake Zuric...

1. A method of processing a biological fluid in an automated biological fluid processing system including a hardware unit comprising a controller including pre-programmed instructions and a disposable fluid circuit mounted on said hardware unit, the method comprising:a) processing a biological fluid;
b) detecting a hardware error in the hardware unit;
c) recognizing said hardware error as being of a certain category wherein said category comprises:
i) a hardware error that generates an alarm and requires termination of said processing,
ii) a hardware error that generates an alert and requires operator intervention and
iii) a hardware error that cannot be corrected by the operator but that does not pose a danger to the patient or donor;
d) pausing said processing when a hardware error of category (iii) is detected; and
e) keeping track of a number of said category (iii) errors;
f) comparing said number of such errors to a preselected number of errors to determine if the number of category (iii) errors exceeds said preselected number.

US Pat. No. 10,688,232

PUMP PRELOAD INDEX/INDICATOR

HeartWare, Inc., Miami L...

1. A control circuit for estimating an amount of work available to be performed by a blood pump implanted in a patient, comprising:a flow rate determination circuit configured to repeatedly determine flow rate data points, each flow rate data point indicative of a flow rate of blood through the pump;
a volume determination circuit configured to calculate, for each determined flow rate data point of a given cardiac cycle of the patient, a first coordinate value characterizing a volume of blood impelled by the pump;
a pressure head determination circuit configured to calculate, for each determined flow rate data point of the given cardiac cycle, a second coordinate value characterizing a pressure head exerted by the pump; and
a pump work determination circuit configured to calculate an area enclosed by the first and second coordinate values of the flow rate data points of the given cardiac cycle, the calculated area is indicative of an amount of work available to be performed by the blood pump.

US Pat. No. 10,688,231

CARDIAC PUMP IMPLANTATION DEVICE AND METHOD

HeartWare, Inc., Miami L...

1. An installation tool for a ventricular assist device comprising a tool body having a proximal end and a distal end, a proximal to distal axis extending therebetween, and a passage extending between the proximal end and the distal end of the tool body along the proximal to distal axis, the distal end of the tool body being configured to releasably engage an anchor ring assembly, the tool body including a major portion having a slot extending between the proximal end and the distal end of the tool body and a elongated strip releasably received in the slot; and the installation tool further includes a plurality of arms movably mounted to the tool body and a slide plate configured to move the plurality of arms.

US Pat. No. 10,688,230

MALLEABLE CANNULA

CircuLite, Inc., Teaneck...

1. A malleable cannula for moving blood from a chamber of the heart of a patient to a heart pump, the malleable cannula comprising:a polymeric jacket having proximal and distal ends, wherein the proximal end is configured to be coupled to the heart pump; and
a malleable member surrounded by the jacket, the malleable member having a proximal end, a distal end, and a lumen extending therebetween and along a lengthwise axis of the malleable cannula, the lumen being configured to transfer blood from the chamber of the heart to the heart pump, the malleable member including a longitudinal strut extending parallel to the lengthwise axis and a plurality of non-helical transverse struts coupled to and extending laterally from the longitudinal strut and around at least a portion of the lumen, the malleable member configured to assume and maintain a formed shape of the malleable cannula,
wherein the longitudinal strut is discontinuous along a lengthwise dimension thereof and is comprised of a plurality of spaced apart segments.

US Pat. No. 10,688,229

BREAST PUMP SYSTEM AND METHODS

ExploraMed NC7, Inc., Mo...

1. A wearable, portable self-powered breast pump system for pumping milk from a breast, comprising:a main body;
a breast adapter;
a milk collection container; and
a pump mechanism configured to pump milk from the breast to the milk collection container;
wherein the breast adapter, the pump mechanism and the milk collection container are collectively sized and shaped to fit within a user's bra, and the pump mechanism and milk collection container are contained within the main body; wherein a latch suction is maintained throughout a pumping session.

US Pat. No. 10,688,228

SUCTION DEVICE

MURATA MANUFACTURING CO.,...

1. A suction device comprising:a pump having a discharge hole and a suction hole;
a first worn portion having a first connection portion;
a second worn portion having a second connection portion;
a passage connecting the first connection portion, the second connection portion, the discharge hole, and the suction hole; and
a switching mechanism provided in a middle of the passage and configured to switch the passage, wherein
the switching mechanism switches the passage between:
a first form in which the first connection portion and the suction hole communicate with each other, the second connection portion and the discharge hole communicate with each other, and the first connection portion and the second connection portion do not communicate with each other;
a second form in which the first connection portion and the discharge hole communicate with each other, the second connection portion and the suction hole communicate with each other, and the first connection portion and the second connection portion do not communicate with each other; and
a third form in which the first connection portion and the second connection portion communicate with each other, both the first connection portion and the second connection portion communicate with the suction hole, and both the first connection portion and the second connection portion do not communicate with the discharge hole.

US Pat. No. 10,688,227

CONTROL APPARATUS AND RELATED METHODS FOR WOUND THERAPY DELIVERY

1. A wound therapy apparatus, comprising:a wound interface that defines an enclosed space over a wound bed that is fluid tight when secured to a skin surface around the wound bed;
a control group that cooperates with the wound interface to regulate input of input fluid comprising a gas having an O2 concentration greater than atmospheric air into the enclosed space and to regulate the withdrawal of output fluid from the enclosed space in order to vary an actual pressure pa within the enclosed space generally between a minimum pressure pmin and a maximum pressure pmax, and in order to vary the actual pressure pa intermediate of the minimum pressure pmin and the maximum pressure pmax in substantial continuous conformance to a target pressure specified continuously as a function of time throughout a pressure cycle; and
wherein the minimum pressure pmin is less than an ambient pressure pamb, the maximum pressure pmax is greater than the ambient pressure pamb, and the target pressure varies continuously between the minimum pressure pmin and the maximum pressure pmax throughout the pressure cycle.

US Pat. No. 10,688,226

CANISTER LID AND CORRESPONDING SYSTEMS AND METHODS

Medline Industries, Inc.,...

1. A canister lid, comprising:an annular perimeter surrounding an interior portion, the annular perimeter interrupted by a suction conduit defined by a suction duct separating a first semicircular lobe and a second semicircular lobe, the first semicircular lobe disposed interior of the annular perimeter, the second semicircular lobe disposed exterior to the annular perimeter, and the suction duct traversing the annular perimeter;
one or more arcuate handles coupled between the annular perimeter and the second semicircular lobe; and
one or more ports extending from the interior portion.

US Pat. No. 10,688,225

SUCTION DEVICE

MURATA MANUFACTURING CO.,...

1. A hand-held suction device having:a housing having a grip portion on an outer surface of the housing, the housing having an elongated shape with a major longitudinal axis and minor lateral axes that are orthogonal to the major longitudinal axis, the grip portion extending in a longitudinal direction of the housing,
a suction port providing fluid communication between an outside and an inside of the housing, the suction port disposed on a distal end of the housing for drawing fluid into the housing,
a flow passage located in the housing and communicating with the suction port, and
a piezoelectric driving unit comprising:
a plate-like structure having a discharge port located in the housing and communicating with the flow passage,
a top plate having an opening facing the discharge port,
a vibrating plate facing the opening and the discharge port, a pump chamber located along a part of the flow passage in the housing, the pump chamber formed by the top plate and the vibrating plate, and communicating with the flow passage at the opening, and
a piezoelectric element attached to one principal surface of the vibrating plate to displace the vibrating plate, wherein a negative pressure is generated in the pump chamber to suck fluid from the opening by increasing a volume of the pump chamber, and the fluid sucked from the opening is discharged through the opening and the discharge port by reducing the volume of the pump chamber,
wherein a space between the top plate and the plate-like structure is a part of the flow passage,
wherein discharging fluid through the discharge port causes fluid to flow from the suction port to the discharge port,
wherein a direction of movement of the one principal surface and another principal surface of the vibrating plate is not aligned with a longitudinal axis of the suction port, and
wherein the grip portion is located on a portion of the housing opposed to the piezoelectric driving unit.

US Pat. No. 10,688,223

SMART RELEASE SYSTEM FOR GROWTH FACTOR DELIVERY AND COMBINED BONE AND VASCULAR GROWTH

The George Washington Uni...

1. A three-dimensional biomimetic structure, comprising:a porous biomimetic three-dimensional scaffold; and
a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold,
wherein the coating comprises a polymer network comprising a first biocompatible polymer, a second biocompatible polymer, a biologically active agent, and a cleavable cross-linking chemical compound,
wherein each of the first biocompatible polymer and the second biocompatible polymer are reversibly cross-linked by the cleavable cross-linking chemical compound to each other or to the biologically active agent,
wherein the biologically active agent is cross-linked to the polymer network when the cleavable cross-linking chemical compound is in an un-cleaved conformation,
wherein the biologically active agent is releasable from the polymer network when the cleavable cross-linking chemical compound is in a cleaved conformation,
wherein the porous biomimetic three-dimensional scaffold defines a first internal channel extending along a first axis and a second internal channel extending along a second axis, and
wherein the first internal channel and the second internal channel intersect.

US Pat. No. 10,688,222

LYOPHILIZED MOLDABLE IMPLANTS CONTAINING AN OXYSTEROL

Warsaw Orthopedic, Inc., ...

1. A lyophilized implant configured to fit at or near a bone defect to promote bone growth, the lyophilized implant comprising a biodegradable polymer in an amount of about 1 wt. % to about 15 wt. % of the implant, mineral particles in an amount from about 10 wt. % to about 51 wt. % of the implant, and (3S,5S,6S,8R,9S,10R,13S,14S,17S) 17-((S)-2-hydroxyoctan-2-yl)-10, 13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol (Oxy133) monohydrate in an amount of about 5 wt. % to about 41.5 wt. % of the implant, wherein the biodegradable polymer comprises porcine-derived collagen, the mineral particles comprising a mixture of beta tri-calcium phosphate and hydroxyapatite in a ratio of 85:15, and the Oxy133 has a particle size of from about 5 microns to about 100 microns.

US Pat. No. 10,688,219

QUILTED IMPLANTABLE GRAFT

Cook Biotech Incorporated...

1. A surgical graft, comprising:a remodelable collagenous material, said remodelable collagenous material comprising a plurality of sheets disposed in a multilayer configuration in which said sheets are bonded to one another in a bonded laminate structure wherein said sheets are bonded to one another by lyophilization of the multilayer configuration to form said bonded laminate structure, wherein said plurality of sheets has up to eight sheets;
one or more lines of lock stitches affixing together said plurality of sheets of remodelable collagenous material supplemental to bonding of said bonded laminate structure;
wherein lines of said one or more lines of lock stitches comprise lock stitches longitudinally spaced apart from one another by at least 1 mm within the lines;
wherein lock stitches longitudinally spaced from one another within said lines of lock stitches are provided by a first suture and a second suture, said first suture defining a plurality of loop segments that penetrate through a thickness of said bonded laminate structure from a first side of said laminate structure to a second side of said laminate structure, said loop segments of said first suture looping over segments of said second suture at said second side of said laminate structure;
wherein said second suture is free of loops in said lock stitches of said one or more lines of lock stitches;
wherein said lines of lock stitches form a pattern across said surgical graft, the pattern including one or more lines of lock stitches inward of and following a periphery of the surgical graft and extending around intersections defined by lines of lock stitches intersecting in a central portion of the surgical graft;
wherein said lines of lock stitches are configured to provide increased strength to the surgical graft;
wherein said lines of lock stitches are formed with a non-resorbable synthetic material; and
wherein said lines of lock stitches are configured to provide continued reinforcement to complement remodeled patient tissue that replaces said remodelable collagenous material after implantation of the surgical graft in a patient.

US Pat. No. 10,688,217

AMINE-FUNCTIONALIZED POLYMERIC COMPOSITIONS FOR MEDICAL DEVICES

KCI Licensing, Inc., San...

1. A wound treatment system comprising a wound treatment apparatus and a wound dressing coupled to the wound treatment apparatus by a conduit, wherein the wound dressing is configured to be coupled to a wound of a patient, and wherein the apparatus comprises a vacuum source configured to apply negative pressure to the wound dressing via the conduit, wherein the wound dressing comprises an amine-functionalized polymer foam and a biologically active agent covalently attached to an amine group on the polymer foam.

US Pat. No. 10,688,216

CROSSLINKED GELS COMPRISING POLYALKYLENEIMINES, AND THEIR USES AS MEDICAL DEVICES

HyperBranch Medical Techn...

1. A method of treating a patient, comprising the steps of:exposing an effective amount of polylysine or polyethyleneimine (PEI) having lysine attached thereto to an activated polyethylene glycol represented by the following formula III to form an adhesive composition; and
applying said adhesive composition to a tissue of the patient,wherein formula III is represented by:wherein R1-III represents independently for each occurrence amino succinimidyl glutarate, succinimidyl glutarate, succinimidyl a-methyl butanoic acid, succinimidyl propionic acid, succinimidyl 3-methyl glutarate, succinimidyl 3,3-dimethyl glutarate, or C(O)(CH2)8C(O)R3-III,wherein R3-III represents independently for each occurrencewherein B represents poly(ethylene glycol) (PEG) with a weight average molecular weight of about 3,400 Daltons, about 4,600 Daltons, about 6,000 Daltons, about 8,000 Daltons, about 10,000 Daltons, or about 20,000 Daltons.

US Pat. No. 10,688,215

FLEXIBLE HYDROGEL WOUND DRESSINGS

FIRST WATER LIMITED, Wil...

1. A wound dressing having improved flexibility for application to the various contours of the body, comprising a backing layer having disposed thereon a discontinuous layer of hydrogel, wherein the discontinuous layer of hydrogel is in the form of discrete islands of hydrogel on the backing layer that are not linked by hydrogel,wherein, in use, an adhesive layer is disposed on at least a part of a wound-facing side of the backing layer, and the adhesive can act to adhere the discrete islands of hydrogel, and, if present any supporting layer on the discrete islands, to the backing layer and/or can adhere the wound dressing to the skin of a user of the dressing.

US Pat. No. 10,688,214

VOLATILE SUBSTANCE EVAPORATION ELEMENT

ZOBELE HOLDING SPA, (IT)...

1. A volatile substance evaporation element comprising:a rod impregnated with volatile substances,
wherein said rod is made of sintered wood,
wherein the porosity of said rod varies between its core and its surface, and
wherein the core extends to up to between 50% and 90% of the width of the rod.

US Pat. No. 10,688,213

MODULAR TRAY AND BRACKET ASSEMBLY FOR EQUIPMENT STERILIZATION

K1 Medical Technologies, ...

1. A bracket assembly, comprising:a. a clip that includes two opposed arms mounted in spaced relation relative to each other, each of the two opposed arms defining an elongated axis and a mounting structure at an exposed end thereof, wherein the mounting structure associated with the first of the two opposed arms comprises a first upper extension and a first lower extension and a first cavity defined therebetween, and wherein the mounting structure associated with the second of the two opposed arms comprises a second upper extension and a second lower extension and a second cavity defined therebetween, and
b. a tray that includes a base defining a plurality of spaced perforations;
wherein the mounting structure associated with the first of the two opposed arms detachably engages a first perforation of the base of the tray with the first upper extension above the base and the first lower extension below the base, and
wherein the mounting structure associated with the second of the two opposed arms engages a second perforation of the base of the tray that is spaced from the first perforation with the second upper extension above the base and the second lower extension below the tray.

US Pat. No. 10,688,212

FILTER-GASKET ASSEMBLY WITH SEAL AND PLACEMENT INDICATOR FOR STERILIZATION RIGID CONTAINER

1. A sterilization packaging system having a volume for containing items to be sterilized, the sterilization packaging system comprising:a lid having an upper surface defining a perimeter and a lip extending downward from the perimeter, wherein the lip includes a plurality of upper openings and a plurality of lower openings;
a base having a lower surface, a first sidewall, a second sidewall, a third sidewall, and a fourth side wall extending from the lower surface, wherein the first sidewall, the second sidewall, the third sidewall, and the fourth sidewall terminate at a seal rim defining a perimeter; and
a sealing assembly, wherein the sealing assembly seals the lid to the seal rim of the base, the sealing assembly comprising:
a gasket having an upper surface, an outer edge, and an inner edge, wherein the upper surface of the gasket comprises a first row of alternating protrusions and indentations and a second row of alternating protrusions and indentations that define a channel therebetween,
a sheet of filter material extending from an inner edge of the gasket, wherein the gasket completely surrounds and partially overlaps the sheet of filter material, wherein the indentations and channel facilitate the delivery of sterilization agent through the sheet of filter material when the sterilization packaging system is sealed with the sealing assembly.

US Pat. No. 10,688,211

ILLUMINATOR WITH ULTRAVIOLET AND BLUE-ULTRAVIOLENT LIGHT SOURCE

Sensor Electronic Technol...

1. An illuminator, comprising:a first set of ultraviolet radiation sources, each ultraviolet radiation source in the first set of ultraviolet radiation sources operating in a wavelength range of approximately 270 nanometers to approximately 290 nanometers;
a second set of ultraviolet radiation sources, each ultraviolet radiation source in the second set of ultraviolet radiation sources operating in a wavelength range of approximately 380 nanometers to approximately 420 nanometers;
a set of sensors for acquiring data regarding at least one object to be irradiated by the first and the second set of ultraviolet radiation sources; and
a control system configured to control and adjust a set of radiation settings for the first and the second set of ultraviolet radiation sources based on the data acquired by the set of sensors, wherein the control system operates the second set of ultraviolet radiation sources to maintain microbial activity within a limit over time and the control system operates the first set of ultraviolet radiation sources to rapidly suppress microbial activity.

US Pat. No. 10,688,210

STORAGE DEVICE INCLUDING ULTRAVIOLET ILLUMINATION

Sensor Electronic Technol...

1. A system comprising:a storage device including a storage area for containing at least one item, wherein the storage area includes at least one shelf for holding the at least one item;
a set of ultraviolet radiation sources configured to generate ultraviolet radiation into the storage area;
a set of sensing devices configured to monitor a set of current conditions of at least one of: the storage area or the at least one item, wherein the set of sensing devices includes a load sensor configured to detect a load and an approximate volume of the at least one item on the at least one shelf, and wherein the set of current conditions includes a presence of the at least one item on the at least one shelf, the load of the at least one item, and the approximate volume of the at least one item; and
a control system configured to control the set of ultraviolet radiation sources based on the set of current conditions, wherein the controlling includes selecting an intensity for the ultraviolet radiation such that the ultraviolet radiation is uniform over the at least one item.

US Pat. No. 10,688,209

COLUMN ASSEMBLY TRANSFER MECHANISM AND SYSTEMS AND METHODS FOR SANITIZING SAME

Curium US LLC, St. Louis...

1. A system comprising:a radiation containment chamber;
an isolator connected to the radiation containment chamber;
a rotating transfer door positioned between the radiation containment chamber and the isolator and including a cavity for receiving a radionuclide generator column assembly,
the transfer door rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator; and
an antimicrobial vapor generator connected to the isolator, wherein the transfer door is adapted to rotate while antimicrobial vapor is introduced into the isolator by the antimicrobial vapor generator.

US Pat. No. 10,688,208

SYSTEMS AND METHODS FOR DECONTAMINATION AND/OR SANITIZATION

Qlean Tech IP, LLC, Mend...

1. A method of decontamination or sanitization comprising:providing, by a water inlet, water;
mixing fluids, at an adapter coupled to a catholyte tank, an anolyte tank, and the water inlet, including two or more of (1) catholyte from a catholyte tank, (2) the provided water from the water inlet, and (3) anolyte from an anolyte tank;
providing, by an outlet coupled to the adapter, the mixed fluid; and
irradiating, by an ultraviolet source, a portion of a user between a decontamination process and a sanitization process.

US Pat. No. 10,688,207

HIGH ENERGY VISIBLE LIGHT-BASED DISINFECTION OF MEDICAL COMPONENTS

C. R. Bard, Inc., Frankl...

1. A disinfection system for an ultrasound probe or a chest sensor, comprising:a container comprising:
a top portion including a first cavity portion;
a bottom portion coupled to the top portion via one or more hinges, the bottom portion including a second cavity portion, wherein the first cavity portion and the second cavity portion together form a cavity having a shape corresponding to a shape of the ultrasound probe or the chest sensor;
an aperture in communication with the cavity shaped to accommodate a cable of the ultrasound probe or the chest sensor; and
a plurality of light sources in both the first cavity portion and the second cavity portion, the plurality of light sources configured to produce disinfecting light in a high energy visible light wavelength range.

US Pat. No. 10,688,206

FILTER SYSTEM WITH OUTLET FUNCTION

AESCULAP AG, Tuttlingen ...

1. A gas-permeable filter system for a sterile container, the filter system comprising:a filter element;
a seal portion which is adapted to sealingly surround a gas exchange opening provided in a sterile container wall section in such a manner that the seal portion rests against the sterile container wall section of the sterile container so that a sterile flow path is formed through the gas exchange opening and the filter element; and
at least one temperature-sensitive adjusting section which releases at least the seal portion from the sterile container wall section when a specified temperature is reached or exceeded such that a non-sterile flow path is formed which allows fluid to be supplied or discharged via the gas exchange opening while bypassing the filter element.

US Pat. No. 10,688,205

CLEANING SYSTEM FOR AN IMAGE PLATE READOUT DEVICE

PaloDEx Group Oy, Tuusul...

1. An image plate readout device comprising:a reader unit that is configured to receive an imaging medium and configured to read an image from the imaging medium;
a detection element adapted to detect a gesture or motion performed by a user, wherein the gesture or motion is spaced apart from the reader unit and the detection element; and
a control unit connected to the reader unit and to the detection element, wherein the control unit is configured to execute a function of the image plate readout device, and wherein the control unit executes the function of the image plate readout device based upon a signal received from the detection element.

US Pat. No. 10,688,204

MICROWAVE PLASMA STERILISATION SYSTEM AND APPLICATORS THEREFOR

CREO MEDICAL LIMITED, Ch...

1. An integrated cable assembly for transporting simultaneously microwave energy and gas to an electrosurgical instrument, the integrated cable assembly comprising a coaxial transmission line inside a sheath, the coaxial transmission line being formed from an inner conductor, an outer conductor and a dielectric material separating the inner conductor from the outer conductor,wherein the inner conductor has a longitudinal bore therethrough for transporting gas to the electrosurgical instrument, and
wherein the integrated cable assembly comprises a longitudinal passageway formed between an outer wall of the outer conductor and an inner wall of the sheath for transporting residual gas away from the electrosurgical instrument.

US Pat. No. 10,688,203

METHODS OF PERFORMING BRACHYTHERAPY

Board of Regents, The Uni...

1. A method of performing brachytherapy, the method comprising:disposing a composition within a biological compartment,
wherein the composition comprises a plurality of radioactive nanoparticles, at least one of the plurality of radioactive nanoparticles comprising:
a metal nanoparticle core;
an outer metal shell disposed over the metal nanoparticle core; and
a metallic radioisotope disposed within the metal nanoparticle core or within the outer metal shell,
wherein the radioactive nanoparticle has a size of 30-500 nm in three dimensions, and
wherein the at least one radioactive nanoparticle has a radioactivity of 0.4 to 400 Bq.

US Pat. No. 10,688,200

UREA-BASED PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS FOR IMAGING AND THERAPY

FIVE ELEVEN PHARMA INC., ...

1. A compound according to Formula IV:or a pharmaceutically acceptable salt thereof,whereinZ is a chelating moiety, or
a group having the structure:

wherein Y10 is CH or N;
L is a bond or a divalent linking moiety comprising 1 to 6 carbon atoms in a chain, a ring, or a combination thereof, wherein at least one carbon atom is optionally replaced with O, —NR3—, or —C(O)—;
R* is a positron emitting radioactive isotope;
R20 is selected from the group consisting of alkyl, alkoxyl, halide, haloalkyl, and CN;
p is an integer from 0 to 4, wherein when p is greater than 1, each R20 is the same or different;
W is a PSMA-targeting ligand;
A4 is a bond or a divalent linking moiety comprising 1 to 10 carbon atoms in a chain, a ring, or a combination thereof, wherein at least one carbon atom is optionally replaced with O, —NR3—, or —C(O)—;
G is O, S, or NR3;
R1 is hydrogen or a carboxylic acid protecting group;
R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, alkylaryl, and heteroaryl;
R11, R12, R13, R14, R15, and R16 are each independently hydrogen, alkyl, alkoxyl, or halide;
R17 and R18 are each independently hydrogen, alkyl, aryl, or alkylaryl;
R19 is selected from the group consisting of alkyl, alkoxyl, halide, haloalkyl, and CN;
m is an integer from 1 to 6; and
o is an integer from 0 to 4, wherein when o is greater than 1, each R19 is the same or different.

US Pat. No. 10,688,198

SALICYLIC ACID-BASED POLYMERIC CEST CONTRAST AGENTS TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF

THE JOHNS HOPKINS UNIVERS...

1. A compound of formula (I), formula (II), formula (III), or formula (IV):wherein:R? is

B is R? or

Z is tetrazole or CO2Q;
Q is H or a protecting group;
W is O or S;
a is an integer selected from the group consisting of 0, 1, 2, 3 and 4;
b is an integer selected from the group consisting of 1, and 4;
n is independently an integer selected from the group consisting of 0, 1, 2, and 3;
s is an integer selected from the group consisting of 0, 1, 2, 3 and 4;
each R is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, alkoxyl, hydroxyl, hydroxyalkyl, carboxyl, acyl, carbonyl, carbamoyl, alkylcarbamoyl, halogen, amino, alkylamino, nitro, nitrile, amide, haloalkyl, aryl, cycloalkyl, aralkyloxyl, and —SO3H;
R1, R2, R3 and R4 are independently selected from the group consisting of H or substituted or unsubstituted linear or branched alkyl, substituted or unsubstituted aryl, and alkoxyl;
R5 is independently H, C1-C4 alkyl or C2-C12 aryl;
each R6 is independently H, Na or a protecting group;
L1 is a linking group selected from the group consisting of —(CH2)m—, —(CH2—CH2—O)t—, —(O—CH2—CH2)t—, —NR7—(CHR8)m—NR7—C(?O)—(CH2)m—C(?O)— and —NR7—(CHR8)m—C(?O)—NR7—(CH2)m—C(?O)—;
L2 is a linking group selected from the group consisting of —(CH2)m—NR7—C(?O)—(CH2)p—, —(CH2)m—C(?O)—NR7—(CH2)p—, —(CH2)m—NR7—C(?O)—NR7—(CH2)p—, —(CH2)m—NR7—C(?O)—NR7—(CH2)p—, —(CH2)m—O—C(?O)—NR7—,—CH2)m—O—C(?O)—NR7—(CH2)p—, —(CH2)m—NR7—C(?O)—O—CH2)p—, —(CH2)m—NR7—C(?O)—O—(CH2)p—, —SO2—NH—(CH2)p—, and —(CH2)m—SO2—NH—(CH2)p—;
L3 is a linking group selected from the group consisting of —C(?O)—NR7—(CH2)m—, —C(?O)—NR7—(CH2)m—NR7—, —C(?O)—NR7—(CH2)m—C(?O)—NR7—, —C(?O)—NR7—(CH2)m—NR7—C(?O)—, —C(?O)—NR7—(CH2)m—NR7—C(?O)—NR7—, —C(?O)—NR7—(CH2)m—NR7—C(?O)—(CH2)p—, —C(?O)—NR7—(CH2)m—C(?O)—NR7—(CH2)p—, —C(?O)—NR7—(CH2)m—(O—CH2—CH2)t—, —C(?O)—NR7—(CH2)m—(CH2—CH2—O)t—(CH2)p—, and —C(?O)—NR7—(CH2)m—(O—CH2—CH2)t— C(?O)—NR7—;
L4 is a linking group selected from the group consisting of —(CH2)m—, —C(?O)—(CH2)m—C(?O)—, —C(?O)—(CH2)m—NR7—C(?O)—,—C(?O)—(CH2—CH2—O)t—C(?O)—, —C(?O)—(CHR8)m—C(?O)—, —C(?O)—(CHR8)m—NR7—C(?O)—,—C(?O)—(CH2—CH2—O)t—C(?O)—, and —C(?O)—(O—CH2—CH2)t—C(?O)—;
each R7 is independently selected from the group consisting of hydrogen, substituted or unsubstituted linear or branched alkyl, alkoxyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl;
each R8 is independently selected from the group consisting of hydrogen, and —COOR6;
m and p are each independently an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7 and 8;
t is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12;
Y is an integer selected from the group consisting of 0 and 1;
G is an azide, an alkyne, a fluoerescent dye moiety that emits light in the visible or near-infrared (NIR) spectrum, or a chelating moiety optionally comprising a metal or a radiometal;
X1 is an integer selected from the group consisting of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, and 2;
X2 and X3 are each independently an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 and 40;
A is selected from the group consisting of:
wherein q is an integer selected from the group consisting of 1, 2, 3, 4, and 5;D is selected from the group consisting of:

or a salt or a stereoisomer thereof.

US Pat. No. 10,688,195

POLYMYXIN B-COATED NANOPARTICLES

NORTHWESTERN UNIVERSITY, ...

1. A composition comprising polymyxin B tethered to the surface of a nanoparticle by a linker, wherein the linker is conjugated to a diaminobutyric acid residue of the polymyxin B.

US Pat. No. 10,688,194

CELL PENETRATING PEPTIDES FOR INTRACELLULAR DELIVERY OF MOLECULES

Aadigen, LLC, Pacidic Pa...

1. A method of delivering a cargo molecule into an individual, comprising administering a nanoparticle or complex into the individual, wherein the nanoparticle or complex comprises a VEPEP-3 cell-penetrating peptide and said cargo molecule, and wherein the VEPEP-3 cell-penetrating peptide comprises an amino acid sequence of:a) X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13 (SEQ ID No: 11), wherein X1 in positions 3, 7, and 11 are, independently from each other, F or W, X2 in positions 4 and 8 are, independently from each other, F, W or Y, X3 is beta-A or S, X4 in positions 2 and 6 are, independently from each other, K, R or L, X5 is E, R or S, X6 is R, T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 i is K, W or R, X12 is R or F and X13 is R or K;
b) X3KX14WWERWWRX14WPRKRK (SEQ ID No: 9), wherein X3 is a beta-alanine or a serine, X14 in positions 3 and 11 are, independently from each other, a non-natural amino acid, and there is a hydrocarbon linkage between the two non-natural amino acids; or
c) X3RWWX14LWWRSWX14RLWRR (SEQ ID No: 10), wherein X3 is a beta-alanine or a serine, X14 in positions 5 and 12 are, independently from each other, a non-natural amino acid, and there is a hydrocarbon linkage between the two non-natural amino acids.

US Pat. No. 10,688,193

PH-SENSITIVE LINKERS FOR DELIVERING A THERAPEUTIC AGENT

1. A metallic nanoparticle complex, comprising a metallic nanoparticle complexed with one or more linkers having the following Formula (I),
wherein
X is
—SH, —NH2, Fmoc-NH—, or —COOH;n is 1 to 6;
P is —C(O)NH— or —C(O)O—;
Q is —R(CH2CH2O)m-, R(—C(O)NH-)z or —R[—C(O)CH2CH2—C(O)NH—(CH2CH2O)m]Y;
R is a bond, —C1-12alkyl or C1-10alkoxy;
m is 1 to 12;
z is 1 to 4; and
Y is 1 or 2,
complexed with one or more polyethylene glycol molecules (PEGs).

US Pat. No. 10,688,192

CLEAVABLE CONJUGATES OF ANTIBIOTICS AND AN ANTIBACTERIAL CELL-PENETRATING PEPTIDE

Purdue Research Foundatio...

1. A method of treating a microbial infection in a patient, wherein the method comprises administering to the patient a pharmaceutical composition comprising a compound of formula:a stereoisomer, tautomer, solvate, pharmaceutically acceptable salt, or derivative thereof,whereinR1 is an antibiotic moiety;
R2 and R3 are each independently H, a C1-C8 branched or unbranched alkyl chain, or a C3-C8 cyclic alkyl;
R4 is H, a C1-C8 branched or unbranched alkyl chain, or a C3-C8 cyclic alkyl;
L3 is C1-C8 branched or unbranched alkyl chain, or a C3-C8 cyclic alkyl;
Z is a linker comprising a disulfide bond (S—S bond); and
n is 3-8, wherein the microbial infection is an infection caused by pathogen S. aureus, S. epidermidis, P. aeruginosa, A. baumannii, K. pneumoniae, E. faecium, enterobacteriaceae, or any combination thereof.

US Pat. No. 10,688,189

MODULATED GUANIDINE-CONTAINING POLYMERS OR NANOPARTICLES

THE FLORIDA INTERNATIONAL...

1. A modulated guanidine substituted polymer, comprising a guanidine moiety on a plurality of repeating units of a polymer, the repeating unit comprises the following structure:
wherein L is a linker and can be null; and R is selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroalkyl, substituted heteroalkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, cycloalkenyl, and substituted cycloalkenyl, alkenyl and substituted alkenyl, alkynyl, haloalkyl, acyl, amino, alkylamino, arylamino and hydroxylalkyl.

US Pat. No. 10,688,184

METHODS AND COMPOSITIONS FOR SELF-REGULATED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT

ACURA PHARMACEUTICALS, IN...

1. An abuse deterrent pharmaceutical composition comprising:a particle portion, wherein the particle portion comprises:
a. a pharmaceutically active ingredient;
b. an acid soluble ingredient comprising one or more of calcium carbonate, dibasic calcium phosphate, tribasic calcium phosphate, and magnesium hydroxide; and
c. a buffering ingredient; and
a pH modifying ingredient,wherein the pH modifying ingredient is present in an amount sufficient to inhibit dissolution of the particle portion when the abuse deterrent pharmaceutical composition is ingested in excess of a dosage appropriate to provide a therapeutic effect.

US Pat. No. 10,688,169

VACCINES AGAINST CARBAPENEM-RESISTANT KLEBSIELLA PNEUMONIAE

1. A synthetic saccharide of general formula (II)
wherein
represents a bond,andL represents a linker;
or a diastereoisomer or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,688,150

TREATMENTS OF OXIDATIVE STRESS CONDITIONS

The Univserity of Vermont...

1. A method, comprising:administering, to a subject at risk of genetically-linked familial pulmonary fibrosis, an inhibitor of GSTP, wherein the inhibitor comprises gamma-glutamyl-S-(benzyl)cysteinyl-R-phenyl glycine diethyl ester, wherein the subject has an identified risk factor of developing pulmonary fibrosis, and wherein the risk of pulmonary fibrosis is genetically linked.

US Pat. No. 10,688,145

POULTRY FEED ADDITIVE

DELACON Biotechnik GmbH, ...

1. A method of improving feed conversion efficiency in antibiotic-free poultry production comprising administering to poultry animal a poultry feed additive composition which is a flowable mixture of phytogenic compounds comprising at leasta. an oil component which is microencapsulated essential thyme oil, and
b. particulate dried quillaja bark powder comprising a saponin component ranging from 3 to 10% (w/w quillaja bark powder),
wherein the mixture contains at least 0.5% saponin component (w/w), and at least 0.2% (w/w) of the oil component per saponin component.

US Pat. No. 10,688,125

NANOPARTICLES AND THEIR USE IN CANCER THERAPY

Midatech Ltd., Abingdon,...

1. A method of treatment of a squamous cell carcinoma in a mammalian subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a nanoparticle comprising a core comprising gold; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising amine-functionalized oligo (ethylene glycol) and at least a second species of ligand comprising a monosaccharide selected from the group: galactose, glucose and N-acetylglucosamine said nanoparticle killing one or more cancer cells ini) the absence of any cytotoxic drug or toxin bound to the nanoparticle core or corona and
ii) in the absence of applied radiation.

US Pat. No. 10,688,122

THIOL AND DISULFIDE-CONTAINING AGENTS FOR INCREASING MEIBOMIAN GLAND LIPID SECRETION

AZURA OPHTHALMICS LTD., ...

1. A method for increasing lipid secretion from a meibomian gland, comprising topically administering to the eyelid margin of the patient in need thereof an ophthalmic composition comprising an ophthalmically-acceptable carrier and an effective amount of at least one agent which increases lipogenesis in the meibomian gland or increases lipid secretion from the meibomian gland, wherein the agent is captopril or selenocysteine.

US Pat. No. 10,688,116

TREATMENT OF METABOLIC DISORDERS IN EQUINE ANIMALS

1. A method of treating or preventing a metabolic disorder in an equine comprising administering an SGLT2 inhibitor or pharmaceutically acceptable form thereof, wherein said SGLT2 inhibitor or pharmaceutically acceptable form thereof consists of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(?-D-glucopyranos-1-yl)-benzene, represented by the following formula:
wherein the metabolic disorder is one or more disorders selected from laminitis, vascular dysfunction, hypertension, hepatic lipidosis, atherosclerosis, hyperadrenocorticism, Pituitary Pars Intermedia Dysfunction and/or Equine Metabolic Syndrome.

US Pat. No. 10,688,112

LIPID DISULFIDE PRODRUGS AND USES RELATED THERETO

Emory University, Atlant...

1. A compound of Formula I,
or salt thereof wherein,
W is

Z is selected from O, S, or Se;
Y is selected from O, S, or NH;
T is an aryl or alkyl linking group,
R1 a saturated hydrocarbon chain having 6 or more carbon atoms;
R2 is R1SST-, hydrogen, alkyl, aryl, phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, naphthyl, or heterocyclyl, wherein R2 is optionally substituted with one or more, the same or different, R10;
R10 is deuterium, alkyl, alkenyl, alkynyl, alkanoyl, halogen, nitro, cyano, hydroxy, amino, amido, mercapto, formyl, carboxy, carbamoyl, azido, alkoxy, alkylthio, alkylamino, (alkyl)2amino, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, benzyl, benzoyl, carbocyclyl, aryl, or heterocyclyl, wherein R10 is optionally substituted with one or more, the same or different, R11; and
R11 is deuterium, halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, benzyl, benzoyl, carbocyclyl, aryl, or heterocyclyl.

US Pat. No. 10,688,106

OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES

FERRING B.V., Hoofddorp ...

1. A method of treating a female subject undergoing embryo transfer, comprisingadministering to the female subject an OBE001 oxytocin receptor antagonist:
(1) only during a time
a) between day 6 following luteinizing hormone (LH) surge (LH+6) and day 9 following LH surge (LH+9) of a natural ovulation cycle;
b) between day 6 following human chorionic gonadotropin (hCG) administration (hCG+6) and day 9 following hCG administration (hCG+9) of an induced ovulation cycle;
c) between day 6 and day 7 of a luteal phase support following oocyte retrieval; or
d) between day 6 and day 9 of a luteal phase support; or
(2) only on the day of transfer of an embryo, wherein the transferred embryo is a blastocyst-stage embryo.

US Pat. No. 10,688,105

METHOD OF TREATING REFRACTORY RHEUMATOID ARTHRITIS ASSOCIATED WITH P53 MUTATION

MACAU UNIVERSITY OF SCIEN...

1. A method of treating a subject suffering from apoptosis-deficient refractory rheumatoid arthritis, wherein the subject harbors a p53 mutant and is resistant against methotrexate, the method comprising the step of administering an effective amount of a quinonemethide triterpenoid or a pharmaceutically tolerable salt, solvate or anhydrate thereof to the subject, wherein the quinonemethide triterpenoid has a structure of Formula (I):wherein represents a single or double bond;
R1 is selected from —CH3, —CH2OH, —OH or —H;
R2 is selected from —CH3, —CH2OH, —OH, —COOH, —COOCH3, ?CH2 or —H;
R3 is selected from —OH, =0 or —H;
R4 is selected from —OH or —H;
R5 is selected from —OH or —H.

US Pat. No. 10,688,101

PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

LES LABORATORIES SERVIER,...

1. A process for the preparation of a compound of formula (I):
wherein:
A1 and A2, each independently of the other, represent a hydrogen atom, a halogen atom, a linear or branched (C1-C6)polyhaloalkyl group, a linear or branched (C1-C6)alkyl group or a cycloalkyl group;
T represents a hydrogen atom, a linear or branched (C1-C6)alkyl group optionally substituted by from one to three halogen atoms, a (C1-C4)alkyl-NR1R2 group, or a (C1-C4)alkyl-OR6 group;
R1 and R2, each independently of the other, represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,
or R1 and R2 form with the nitrogen atom carrying them a heterocycloalkyl;
R3 represents a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a cycloalkyl group, a (C3-C10)cycloalkyl-(C1-C6)alkyl group wherein the alkyl moiety is linear or branched, a heterocycloalkyl group, an aryl group or a heteroaryl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;
R4 represents an aryl group, a heteroaryl group, a cycloalkyl group or a linear or branched (C1-C6)alkyl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;
R5 represents a hydrogen or halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group;
R6 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group;
Ra, Rb, Rc and Rd, each independently of the others, represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, an aryl group, a heteroaryl group, a halogen atom, a linear or branched (C1-C6)alkoxy group, a hydroxy group, a linear or branched (C1-C6)polyhaloalkyl group, a trifluoromethoxy group, —NR7R7?, nitro, R7-CO—(C0-C6)alkyl-, R7—CO—NH—(C0-C6)alkyl-, NR7R7?—CO—(C0-C6)alkyl-, NR7R7?—, CO—(C0-C6)alkyl-O—, R7—SO2—NH—(C0-C6)alkyl-, R7—NH—CO—NH—(C0-C6)alkyl-, R7—O—CO—NH—(C0-C6)alkyl-, a heterocycloalkyl group, or the substituents of one of the pairs (Ra,Rb), (Rb,Rc), or Rc,Rd) form together with the carbon atoms carrying them a ring composed of from 5 to 7 ring members, which ring may have from one to 2 hetero atoms selected from oxygen and sulphur, wherein one or more carbon atoms of the ring defined hereinbefore may be deuterated or substituted by from one to 3 groups selected from halogen and linear or branched (C1-C6)alkyl;
R7 and R7?, each independently of the other, represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, an aryl group or a heteroaryl group, or R7 and R7?, together with the nitrogen atom carrying them, form a heterocycle composed of from 5 to 7 ring members;
it being understood that:
“aryl” means a phenyl, naphthyl, biphenyl or indenyl group,
“heteroaryl” means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and having from 1 to 4 hetero atoms selected from oxygen, sulphur and nitrogen (including quaternary nitrogens),
“cycloalkyl” means any mono- or bi-cyclic, non-aromatic, carbocyclic group having from 3 to 10 ring members,
“heterocycloalkyl” means any mono- or bi-cyclic, non-aromatic, condensed or spiro group composed of from 3 to 10 ring members and having from 1 to 3 hetero atoms selected from oxygen, sulphur, SO, SO2 and nitrogen,
wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the alkyl, alkenyl, alkynyl and alkoxy groups may be optionally substituted by from 1 to 3 groups selected from optionally substituted, linear or branched (C1-C6)alkyl, (C3-C6)spiro, optionally substituted, linear or branched (C1-C6)alkoxy, (C1-C6)alkyl-S-, hydroxy, oxo (or N-oxide where appropriate), nitro, cyano, —COOR?, —OCOR?, NR?R?, linear or branched (C1-C6)polyhaloalkyl, trifluoromethoxy, (C1-C6)alkylsulphonyl, halogen, optionally substituted aryl, heteroaryl, aryloxy, arylthio, cycloalkyl, heterocycloalkyl optionally substituted by one or more halogen atoms or alkyl groups, wherein R? and R?, each independently of the other, represent a hydrogen atom or an optionally substituted, linear or branched (C1-C6)alkyl group,
or an enantiomer, a diastereoisomer, or an addition salt thereof with a pharmaceutically acceptable acid or base,
which process comprises subjecting a compound of formula (II)

to a Heck reaction in an aqueous or organic medium, in the presence of a palladium catalyst, a base, a phosphine and a compound of formula (III):

wherein Alk represents a linear or branched (C1-C6)alkyl, to obtain the compound of formula (IV):

the aldehyde function of which compound of formula (IV) is oxidized to a carboxylic acid to form a compound of formula (V):

which compound of formula (V) is then subjected to peptide coupling with a compound of formula (VI):

to yield a compound of formula (VII):

the ester function of which compound of formula (VII) is hydrolyzed to yield the corresponding carboxylic acid or carboxylate, which may be converted into an acid derivative, including an acyl chloride or anhydride, which compound is then coupled with an amine NHR3R4, to yield the compound of formula (I),
which compound of formula (I) may be purified according to a conventional separation technique, which is converted, if desired, into its addition salts with a pharmaceutically acceptable acid or base and which is optionally separated into its isomers according to a conventional separation technique,
wherein, at any time considered appropriate in the course of the above-described process, certain groups of the reagents or intermediates of synthesis may be protected and then deprotected according to the requirements of synthesis.

US Pat. No. 10,688,099

METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS

PTC Therapeutics, Inc., ...

1. A method of modulating the amount of one or more RNA transcripts of one or more genes, comprising administering to a subject in need thereof a compound of Formula (IIa1):or a free acid, free base, salt, isotopologue, stereoisomer, racemate, enantiomer, diastereomer or tautomer thereof, wherein:R1 is heterocyclyl;
wherein heterocyclyl is optionally substituted with one, two or three R3 substituents and optionally, with one additional R4 substituent; or,
wherein heterocyclyl is optionally substituted with one, two, three or four R3 substituents;
R2 is phenyl;
wherein phenyl is optionally substituted with one, two or three R6 substituents and optionally, with one additional R7 substituent;
Ra is, in each instance, independently selected from hydrogen, halogen, C1-8alkyl or deuterium;
Rb is hydrogen, halogen, C1-8alkyl, C1-8alkoxy or deuterium;
Rc is hydrogen, halogen, C1-8alkyl or deuterium;
R3 is, in each instance, independently selected from cyano, halogen, hydroxy, oxo, C1-8alkyl, halo-C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkoxy, halo-C1-8alkoxy, C1-8alkoxy-C1-8alkyl, C1-8alkoxy-carbonyl, amino, C1-8alkyl-amino, (C1-8alkyl)2-amino, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, (C1-8alkyl)2-amino-C1-8alkyl, amino-C1-8alkyl-amino, C1-8alkyl-amino-C1-8alkyl-amino, (C1-8alkyl-amino-C1-8alkyl)2-amino, (C1-8alkyl)2-amino-C1-8alkyl-amino, [(C1-8alkyl)2-amino-C1-8alkyl]2-amino, (C1-8alkyl-amino-C1-8alkyl)(C1-8alkyl)amino, [(C1-8alkyl)2-amino-C1-8alkyl](C1-8alkyl)amino, C1-8alkoxy-C1-8alkyl-amino, (C1-8alkoxy-C1-8alkyl)2-amino, (C1-8alkoxy-C1-8alkyl)(C1-8alkyl)amino, C1-8alkyl-carbonyl-amino, C1-8alkoxy-carbonyl-amino, hydroxy-C1-8alkyl, hydroxy-C1-8alkoxy-C1-8alkyl, hydroxy-C1-8alkyl-amino, (hydroxy-C1-8alkyl)2-amino or (hydroxy-C1-8alkyl)(C1-8alkyl)amino;
R4 is C3-14cycloalkyl, C3-14cycloalkyl-C1-8alkyl, C3-14cycloalkyl-amino, aryl-C1-8alkyl, aryl-C1-8alkoxy-carbonyl, aryl-sulfonyloxy-C1-8alkyl, heterocyclyl or heterocyclyl-C1-8alkyl; wherein, each instance of C3-14cycloalkyl, aryl and heterocyclyl is optionally substituted with one, two or three R5 substituents;
R5 is, in each instance, independently selected from halogen, hydroxy, cyano, nitro, C1-8alkyl, halo-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, amino, C1-8alkyl-amino, (C1-8alkyl)2-amino or C1-8alkyl-thio;
R6 is, in each instance, independently selected from halogen, hydroxy, cyano, nitro, C1-8alkyl, C2-8alkenyl, halo-C1-8alkyl, hydroxy-C1-8alkyl, C1-8alkoxy, halo-C1-8alkoxy, C1-8alkoxy-C1-8alkyl, amino, C1-8alkyl-amino, (C1-8alkyl)2-amino or C1-8alkyl-thio; and,
R7 is C3-14cycloalkyl, C3-14cycloalkyl-oxy, aryl, heterocyclyl or heteroaryl,
wherein the gene is selected from the group consisting of ABCA1, ABCB7, ABCC1, ABHD10, ABL2, ABLIM3, ACACA, ACADVL, ACAT2, ADAM12, ADAM15, ADAM17, ADAM33, AFF2, AGK, AGPAT3, AGPS, AHCYL2, AHDC1, AHRR, AJUBA, AK021888, AK310472, AKAP1, AKAP9, AKNA, ALCAM, ALDH4A1, AMPD2, ANK2, ANKFY1, ANKHD1-EIF4EBP3, ANKRD17, ANKS6, ANP32A, ANXA11, ANXA6, AP2B1, APAF1, APLP2, APP, APPL2, APTX, ARHGAP22, ARID1A, ARID2, ARMCX3, ASAP1, ASL, ASNS, ASPH, ATAD2B, ATF7IP, ATG9A, ATMIN, ATP2C1, ATXN3, AURKA, AXIN1, B4GALT2, BACE1, BAG2, BASP1, BC033281, BCAR3, BEND6, BICD1, BIN1, BNC1, BRD2, BRPF1, BSCL2, BTBD10, BZW1, C11orf30, C11orf73, C17orf76-AS1, C4orf27, C5orf24, C6orf48, C9orf69, CAB39, CALU, CAMKK1, CAPNS1, CASC3, CASP8AP2, CAV1, CCAR1, CCDC77, CCDC88A, CCDC92, CCT6A, CD276, CD46, CDC25B, CDC40, CDC42BPA, CDCA7, CDH11, CDH13, CDK11B, CDK16, CDKAL1, CEP68, CFLAR, CHD8, CIZ1, CLIC1, CLK4, CNOT1, COG1, COL12A1, COL1A1, COL6A1, COPS7B, CPEB2, CREB5, CRLS1, CRTAP, CSDE1, CSNK1A1, CTDSP2, CTNND1, CUL2, CUL4A, CUX1, CYB5B, CYBRD1, CYP51A1, DAB2, DACT1, DARS, DAXX, DCAF10, DCAF11, DCBLD2, DCUN1D4, DDAH1, DDAH2, DDHD2, DDR1, DDX39B, DDX42, DENND1A, DENND1B, DENND5A, DGCR2, DGKA, DHCR24, DHCR7, DHFR, DHX9, DIAPH1, DIAPH3, DIS3L, DKFZp434M1735, DKK3, DLC1, DNM2, DOCK1, DPP8, DSEL, DST, DSTN, EBF1, EEA1, EEF1A1, EFCAB14, EGR1, EHMT2, EIF2B3, EIF4G1, EIF4G2, EIF4G3, ELF2, ENG, ENPP2, ENSA, EPN1, EPT1, ERC1, ETV5, EXO1, EXTL2, EYA3, FADS1, FADS2, FAF1, FAM111A, FAM198B, FAM219A, FAM219B, FAM3C, FAM65A, FBXO10, FBXO18, FBXO31, FBXO34, FBXO9, FDFT1, FDPS, FER, FEZ1, FGD5-AS1, FGFRL1, FHOD3, FLII, FLNB, FN1, FNBP1, FOCAD, FOS, FOSB, FOSL1, FOXK1, FUS, FYN, GABPB1, GALC, GALNT1, GAS7, GBA2, GCFC2, GGCT, GHDC, GIGYF2, GJC1, GMIP, GNA13, GNAS, GNL3L, GOLGA2, GOLGA4, GOLGB1, GORASP1, GPR1, GPR89A, GPSM2, GREM1, GRK6, GSE1, GTF2H2B, HAS2, HAT1, HAUS3, HAUS6, HDAC7, HEG1, HLA-A, HLA-E, HLTF, HMGA1, HMGB1, HMGCR, HMGCS1, HMOX1, HNRNPR, HNRNPUL1, HP1BP3, HRH1, HSD17B12, HSD17B4, HTT, IARS, IDH1, IDI1, IGF2BP2, IL6ST, INHBA, INSIG1, IQCE, ITGAV, ITGB5, ITM2C, ITSN1, KANSL3, KCNK2, KIAA1033, KIAA1143, KIAA1199, KIAA1522, KIAA1524, KIAA1549, KIAA1715, KIF14, KIF2A, KIF3A, KLC1, KLC2, KLF6, KLHL7, KRT18, KRT19, KRT34, KRTAP2-3,LAMA2, LAMB1, LARP4, LARP7, LATS2, LDLR, LEMD3, LGALS8, LIMS1, LINC00341, LINC00657, LMAN2L, LMO7, LONP1, LOX, LRCH4, LRIG1, LRP8, LRRC8A, LSS, LTBR, LUC7L2, LZTS2, MADD, MAGED4, MAGED4B, MAN1A2, MAP4K4, MBD1, MBOAT7, MDM2, MED1, MEDAG, MEF2D, MEIS2, MEMO1, MEPCE, MFGE8, MICAL2, MINPP1, MKL1, MKLN1, MKNK2, MLLT4, MLST8, MMAB, MMS19, MMS22L, MPPE1, MPZL1, MRPL3, MSANTD3, MSC, MSH2, MSH6, MSL3, MSMO1, MSRB3, MTAP, MTERFD1, MTHFD1L, MTMR9, MTRR, MUM1, MVD, MVK, MYADM, MYLK, MYO1D, MYO9B, MYOF, NAA35, NADK, NASP, NAV1, NAV2, NCOA1, NCOA3, NCOA4, NCSTN, NELFA, NEO1, NEURL1B, NF2, NFE2L1, NFX1, NID1, NID2, NIPA1, NKX3-1, NOL10, NOMO3, NPEPPS, NRD1, NREP, NRG1, NSUN4, NT5C2, NT5E, NTNG1, NUDT4, NUP153, NUP35, NUP50, NUPL1, NUSAP1, ODF2, OS9, OSBPL6, OSMR, P4HA1, P4HB, PABPC1, PAK4, PAPD4, PARD3, PARN, PARP14, PARP4, PARVB, PCBP2, PCBP4, PCDHGB3, PCGF3, PCM1, PCMTD2, PCNXL2, PCSK9, PDE4A, PDE7A, PDLIM7, PDXDC1, PEPD, PEX5, PFKP, PHF19, PHF8, PHRF1, PHTF2, PI4K2A, PIEZO1, PIGU, PIK3C2B, PITPNA, PITPNB, PITPNM1, PLAU, PLEC, PLEKHB2, PLSCR3, PLXNB2, PLXNC1, PMS1, POLE3, POLR3D, POSTN, POU2F1, PPAPDC1A, PPARA, PPHLN1, PPIP5K1, PPP1R12A, PPP6R1, PPP6R2, PRKACB, PRKDC, PRMT1, PRNP, PRSS23, PSMA4, PSMC1, PSMD6, PTK2B, PTPN14, PUF60, PUS7, PVR, PXN, QKI, RAB23, RAB2B, RAB34, RAD1, RAD23B, RALB, RAP1A, RAP1GDS1, RARG, RASSF8, RBCK1, RBFOX2, RBM10, RCC1, RFTN1, RFWD2, RGS10, RGS3, RIF1, RNF14, RNF19A, RNF38, RNFT1, RPL10, RPS6KC1, RRBP1, RWDD4, SAMD9, SAMD9L, SAR1A, SART3, SCAF4, SCAF8, SCD, SCLT1, SCO1, SDCBP, SEC14L1, SEC22A, SEC24B, SEC61A1, SEPT9, SERPINE2, SF1, SGOL2, SH3RF1, SKIL, SLC25A17, SLC39A3, SLC41A1, SLC4A4, SLC7A6, SLC7A8, SMARCA4, SMARCC2, SMC4, SMC6, SMCHD1, SMG1, SMPD4, SMYD3, SMYD5, SNAP23, SNHG16, SNX14, SOCS2, SON, SOS2, SPATA20, SPATS2, SPG20, SPRED2, SQLE, SQRDL, SQSTM1, SRCAP, SREBF1, SREK1, SRSF3, STARD4, STAT1, STAT3, STAU1, STC2, STEAP2, STRIP1, STRN3, STX16, SUPT20H, SYNE1, SYNE2, SYT15, SYTL2, TACC1, TAF2, TANC2, TARBP1, TARS, TBC1D15, TBL2, TCF7L2, TENC1, TENM2, TEP1, TET3, TFCP2, TGFBI, TGFBR1, TGFBRAP1, THADA, THAP4, THRB, TIMP2, TJP2, TLE3, TLK1, TMEM154, TMEM47, TMEM63A, TNC, TNFAIP3, TNFRSF12A, TNIP1, TNKS1BP1, TNPO3, TNS1, TNS3, TOE1, TOMM40, TOMM5, TOPORS, TP53INP1, TRAF3, TRAK1, TRAPPC12, TRIB1, TRIM2, TRIM23, TRIM26, TRIM28, TRIM65, TRMT1L, TRPS1, TSC2, TSHZ1, TSPAN2, TTC7A, TUBB2C, TUBB3, TXNL1, TXNRD1, U2SURP, UBAP2L, UBE2G2, UBE2V1, UBQLN4, UCHL5, UHMK1, UHRF1BP1L, UNC5B, USP19, USP7, VANGL1, VARS2, VCL, VIPAS39, VPS13A, VPS29, VPS51, VWA8, WDR19, WDR37, WDR48, WIPF1, WNT5B, WSB1, WWTR1, XIAP, XRN2, YAP1, YES1, YPEL5, YTHDF3, Z24749, ZAK, ZBTB10, ZBTB24, ZBTB7A, ZC3H12C, ZC3H14, ZC3H18, ZCCHC11, ZEB1, ZEB2, ZFAND1, ZFAND5, ZHX3, ZMIZ1, ZMYM2, ZNF12, ZNF148, ZNF219, ZNF227, ZNF24, ZNF268, ZNF28, ZNF281, ZNF335, ZNF37A, ZNF37BP, ZNF395, ZNF583, ZNF621, ZNF652, ZNF655, ZNF674, ZNF74, ZNF764, ZNF778, ZNF780A, ZNF827, ZNF839 and ZNF91.

US Pat. No. 10,688,097

ORGANIC COMPOUNDS

INTRA-CELLULAR THERAPIES,...

1. A compound of formula I,
in free or salt form; or
a compound of formula II,

in free or salt form; or
a compound of formula III,

in free or salt form.

US Pat. No. 10,688,096

METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS

The University of Chicago...

1. A method of treating or reducing incidence of a central sleep apnea syndrome (CSAS) disorder in an individual diagnosed with CSAS comprising administering a therapeutically effective amount of DL-propargylglycine (PAG), beta cyano L-alanine (BCA), or combinations thereof, wherein the individual is not suffering from anatomically compromised airway patency of an obesity individual.

US Pat. No. 10,688,095

COMPOUNDS AND THEIR USE FOR REDUCING URIC ACID LEVELS

Acquist LLC, Chatham, NJ...

1. A compound selected from the group consisting ofa) compounds having a structure represented by Formula (II):
whereinW is O, Y is OH, X, is each O, S, NR2 or N(R2)2;
A is phenyl, heteroaryl, C5-C10 branched or unbranched cycloalkyl, C6-C10 bicycloalkyl or C5-C10 spirocycloalkyl;
each Z is independently present or absent and, if present, is independently selected from one or more halogen atoms, —CN, —CF3, —OCF3, —OCHF2, —OR2, —C(O)R2, SR2, —S(O)gR3 where g is 1 or 2, —N(R2)2, —NO2, —CO2R2, —OCO2R3, OC(O)R2, —CON(R2)2, —NR2C(O)R2, —SO2N(R2)2, —NR2SO2R3, —NR2SO2N(R2)2 or —NR2C(O)N(R2)2, —C(O)NHOR2, alkyl, aryl, alkenyl, alkynyl and cycloalkyl;wherein each R1 is C1-C8 branched or unbranched alkyl, optionally substituted with Z;wherein each R2 is H;wherein each R3 is independently alkyl or aryl, optionally substituted with one or more halogen atoms or OR2; andwherein a, b, c, d, and e are each independently carbon or nitrogen, or four of a, b, c, d, and e are each independently carbon or nitrogen and one of a, b, c, d, and e is O, with the proviso that at least three of a, b, c, d and e are nitrogen, and Z is not connected directly to nitrogen or oxygen; andb) tautomers of any of the foregoing compounds.

US Pat. No. 10,688,091

ARIPIPRAZOLE PRODRUG COMPOSITION

ALKERMES PHARMA IRELAND L...

1. A composition comprising:(a) a population of particles of an aripiprazole prodrug having a volume based particle distribution size (Dv50) of between 50 and 700 nm as determined by light scattering techniques;
(b) at least one surface stabilizer comprising an adsorbed component which is adsorbed on the surface of the aripiprazole prodrug particles and a free component available for solubilisation of the aripiprazole prodrug;
wherein the ratio of aripiprazole prodrug to surface stabilizer is about 17:1;
wherein the aripiprazole prodrug has the formula:

where n is zero or an integer less than 20; and
wherein the at least one surface stabilizer is selected from the group consisting of carboxymethyl cellulose and polyoxyethylene sorbitan fatty acid esters.

US Pat. No. 10,688,087

PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC METHODS EMPLOYING A COMBINATION OF A MANGANESE COMPLEX COMPOUND AND A NON-MANGANESE COMPLEX FORM OF THE COMPOUND

PLEDPHARMA AB, Stockholm...

1. A method of reducing uptake of manganese to the brain of a patient when a pathological condition in a patient caused by superoxide radicals is treated by administration of manganese N,N?-bis-(pyridoxal-5-phosphate)-ethylenediamine-N,N?-diacetic acid (MnDPDP) or a salt thereof in an amount effective to treat the pathological condition, the method comprising administering, as a second component, N,N?-bis-(pyridoxal-5-phosphate)-ethylenediamine-N,N?-diacetic acid (DPDP) or a salt or non-manganese complex thereof in an amount effective to reduce uptake of manganese to the brain of the patient as compared with administration of MnDPDP in the absence of the second component, wherein the second component is administered in an amount of about 1 to 20 ?mol/kg body weight, wherein MnDPDP and the second component are included in a MnDPDP:second component molar ratio in the range of about 1:1 to 1:10, and wherein the administration of MnDPDP and/or the administration of the second component are optionally together with one or more physiologically acceptable carriers and/or excipients.

US Pat. No. 10,688,084

METHOD OF USE OF NOVEL NAPROXEN DERIVATIVES

Kazan Federal University,...

1. A method of reducing at least one of inflammation, pain, and body temperature of a subject, the method comprising administering to the subject a therapeutically effective amount of a compound represented by structural formula I:

US Pat. No. 10,688,082

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula (I):
wherein:
R1 is: halogen; or linear, branched or cyclic alkoxy of up to 6 carbon atoms which is optionally substituted on an alkyl carbon thereof by one or more: (i) halogen; (ii) —OH (iii) alkoxy, or (iv) heterocyclyl moiety, which heterocyclyl moiety is optionally substituted by an aryl moiety, which aryl moiety is optionally substituted with a halogen, or linear-, branched- or cyclic-alkyl of up to 6 carbon atoms, which alkyl substituent is optionally substituted by one or more halogen, lower-alkoxy or —OH;
R2 is: (a) —H; (b) halogen; or (c) linear, branched or cyclic alkoxy of up to 6 carbon atoms which is optionally substituted on an alkyl carbon thereof by one or more: (i) halogen; (ii) —OH (iii) alkoxy; or (iv) heterocyclyl moiety, which heterocyclyl moiety is optionally substituted by an aryl moiety, which aryl moiety is optionally substituted with a halogen, or liner-, branched- or cyclic-alkyl of up to 6 carbon atoms, which alkyl substituent is optionally substituted by one or more halogen, lower-alkoxy or —OH; andZ is:(I) a moiety of the Formula R3—CH2—, wherein R3 is:
(a) aryl, which may optionally be substituted with one or more:
(i) halogen;
(ii) heterocyclyl, which may optionally be substituted by one or more: (iia) a linear, branched, or cycloalkyl moiety comprising up to about 6 carbon atoms; (iib) (RIa)—O—(C?O)—, wherein: RIa is a linear-, branched-, or cyclic-alkyl of up to 6 carbon atoms; or (iic) —OH;
(iii) (RIb)2N—, wherein: RIb is independently: —H; or is a linear-, branched-, or cyclic-alkyl of up to 6 carbon atoms, or wherein both RIb are taken together with the nitrogen to which they are attached form a C3-6-cyclo-amine;
(iv) linear, branched, or cycloalkyl moiety comprising up to about 6 carbon atoms, which is optionally substituted with one or more: (iva) halogen: (ivb) aryl; or
(ivc) lower alkoxy which is optionally substituted with one or more halogen;
(v) —CN;
(vi) heteroaryl: which may optionally be substituted with one or more: (via) alkyl wherein said alkyl is a linear-, branched-, or cyclic-alkyl of up to 6 carbon atoms: or (vib) heterocyclyl, which heterocyclyl may optionally be substituted by one or more linear-, branched-, or cyclic-alkyl of up to 6 carbon atoms; or
(vii) RIc—O—, wherein: RIc is aryl or a linear, branched or cyclic-alkyl of up to 6 carbon atoms, which may optionally be substituted on any carbon atom thereof with one or more halogen;
(b) heteroaryl, optionally substituted with one or more: (i) linear, branched or cyclic-alkyl of up to 6 carbon atoms; or (ii) heterocyclyl which is optionally substituted with linear, branched or cyclic-alkyl of up to 6 carbon atoms:
(c) heterocyclyl, optionally substituted with one or more: (i) —OH; or (ii) linear, branched or cyclic-alkyl of up to 6 carbon atoms;
(d) arylheterocyclyl, optionally substituted with one or more of: (i) ?O; (ii) halogen; or
(e) heteroarylheterocyclyl; or
(II) a heteroaryl moiety bonded to the pyrazolo-quinazolinyl core through any available ring carbon therein, which heteroaryl moiety comprises 2, 3, or 4 carbon atoms and 1 to 3 heteroatoms which are independently N, S, or O, and wherein, said heteroaryl moiety may optionally be substituted with:
(a) linear, branched or cyclic-alkyl of up to 6 carbon atoms, which may optionally be substituted with aryl or heteroaryl;
(b) (RId)2N—, wherein: RId is —H or linear, branched or cyclic-alkyl of up to 6 carbon atoms, or wherein both RId together with the nitrogen atom to which they are bonded form C3-6-cyclo-amino, and wherein said alkyl may optionally be substituted on one or more carbon atoms thereof by phenyl which is optionally substituted by one or more halogens;
(c) aryl;
(d) heteroaryl; or
(e) heterocycle, which may optionally be substituted with one or more:
(i) linear, branched or cyclic-alkyl of up to 6 carbon atoms; (ii) aryl, which may optionally be substituted with one or more halogen; or
(III) a moiety of the Formula R4—(C?O)—, wherein R4 is:
(a) heterocyclyl, which may optionally be substituted by one or more: (i) (RIe)—O—(C?O)—, wherein RIe is linear, branched or cyclic-alkyl of up to 6 carbon atoms; (ii) linear, branched or cyclic-alkyl of up to 6 carbon atoms, which alkyl may optionally be substituted with one or more aryl, which aryl may optionally be substituted with one or more halogens: (iii) aryl which may optionally be substituted with one or more halogens; or (iv) heteroaryl;
(b) a spiroheterocyclyl comprising at least 1 heteroatom in each of the fused rings and up to 5 carbon atoms comprising each of the fused rings, which spiroheterocyclyl may optionally be substituted with: (i) linear, branched or cyclic-alkyl of up to 6 carbon atoms, which may optionally be substituted on one or more carbon atoms thereof with aryl; (ii) aryl; or (iii) (RIf)—O—(C?O)—, wherein RIf is -linear-, -branched-C1-6-alkyl, or -cyclic-C3-6-alkyl; or
(c) (RIg)2N—, wherein: RIg is independently for each occurrence:
(i) —H;
(ii) aryl, which may optionally be substituted with one or more halogen;
(iii) heteroaryl
(iv) linear, branched or cyclic-alkyl of up to 6 carbon atoms, wherein said alkyl is optionally substituted on one or more carbon atoms thereof with one or more: (iva) aryl, which aryl may optionally be substituted with one or more halogens; or (ivb) heteroaryl;
(v) both R together with the nitrogen atom to which they are bonded form C3-6-cyclo-amino, and wherein the alkyl portion of said cyclo-amino may optionally be substituted with one or more halogens; or
(vi) one RIg is a protecting group and the other is —H or linear, branched, or cyclic alkyl of up to 6 carbon atoms.

US Pat. No. 10,688,081

AUTOTAXIN INHIBITOR COMPOUNDS

SABRE THERAPEUTICS LLC, ...

1. A compound of Formula (III), or a pharmaceutically acceptable salt, or solvate thereof:
wherein,
R1 is Cl;
R2 is H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(?O)R9, —S(?O)2R9, —S(?O)2N(R10)2, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, or C3-C6cycloalkyl;
R3 is H, halogen, —CN, —OH, C1-C4alkyl, C1-C4fluoroalkyl, C1-C4deuteroalkyl, C1-C4alkoxy, or C1-C4fluoroalkoxy;
W is CH, CF or N;
each RA is H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(?O)R9, —S(?O)2R9, —S(?O)2N(R10)2, C1-C6alkyl, or C1-C6fluoroalkyl;
L1 is absent, C1-C6alkylene, or C3-C6cycloalkylene;
Q is —CO2H, —CO2(C1-C6alkyl), —OH, —CN, —B(OH)2, —C(?O)NHSO2R9, —C(?O)N(R10)2, —SO2NHC(?O)R9, —CN, tetrazolyl, —OP(?O)(OH)2, —P(?O)(OH)2 or carboxylic acid bioisostere;
Ring B is a monocyclic heteroaryl;
each RB is independently H, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(?O)R9, —S(?O)2R9, —S(?O)2N(R10)2, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted C2-C10heterocycloalkyl, substituted or unsubstituted phenyl, C1-C4alkylene-(substituted or unsubstituted phenyl), substituted unsubstituted monocyclic heteroaryl, C1-C4alkylene-(substituted or unsubstituted monocyclic heteroaryl), a substituted or unsubstituted bicyclic heteroaryl, or C1-C4alkylene-(substituted or unsubstituted bicyclic heteroaryl);
n is 0, 1, or 2;
R9 is C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, a substituted or unsubstituted monocyclic heteroaryl, or a substituted or unsubstituted bicyclic heteroaryl;
each R10 is independently H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, a substituted or unsubstituted phenyl, or a substituted or unsubstituted monocyclic heteroaryl; or
two R10 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle.

US Pat. No. 10,688,080

COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT

UNIVERSITY OF SOUTH FLORI...

1. A composition, comprising a beta-lactamase inhibitor selected from of the following structures:
wherein each W is independently selected from: O, NO, S, SO, CH2, NMe2, CHMe, C(Me)2, CF2, or SO2;
wherein X and Y are independently selected from: O, NH, NO, NMe, NMe2, S, SO, SO2, CF2, C(?O), CH, N, CR2, (CH2)n, where n=1 or 2, a bond, or CMe2 or wherein X—Y is selected from: CH?CH, cyclopropyl, or (CH2)n, where n=1 or 2;
wherein each R1 is independently selected from: H, a halogen, Me, iPr, tBu, or, optionally substituted aryl or heteroaryl;
wherein each R2 is independently selected from: H, a halogen CH3, an optionally substituted alkyl, or optionally substituted aryl or heteroaryl, OMe, NH2, N(Me)2, or an alkyl substituted amine;
wherein each R3 is independently selected from: H, aryl, thiophene, imidazole, pyrimidone, or optionally substituted aryl or heteroaryl, Me, iPr, tBu, or; aryl, thiophene, imidazole, pyrimidone;
wherein each R4 is independently selected from: H, Me, iPr, tBu, substituted and unsubstituted aryl or heteroaryl thiophene, imidazole, pyrimidone, acylated substituted and unsubstituted aryl or heteroaryl;
wherein each R5 is independently selected from: H, F, Me, iPr, tBu, optionally substituted aryl or heteroaryl, aryl, thiophene, imidazole, pyrimidone; and
wherein each R6 is independently selected from: H, Me, iPr, tBu, substituted or unsubstituted aryl or heteroaryl.

US Pat. No. 10,688,079

COMPOUNDS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS

Piramal Enterprises Limit...

1. A method of treating a human papillomavirus (HPV)-associated cancer in a subject infected with HPV, the method comprising administering to the subject a therapeutically effective amount of a compound of formula:
or a pharmaceutically acceptable salt or solvate thereof;
wherein the HPV-associated cancer is selected from anal cancer, vulvar cancer, vaginal cancer, penile cancer, cervical cancer, head and neck cancer, lung cancer, non-melanoma skin cancer, and cancer of the conjunctiva.

US Pat. No. 10,688,074

COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT FOR INHIBITING BLOOD CANCER OR METASTASIS

Enzychem Lifesciences Cor...

1. A method of reducing a cytokine in a subject comprising:administering to the subject a monoacetyldiacylglycerol of Formula I:

wherein R1 and R2 are independently a fatty acid group comprising 14 to 20 carbon atoms, thereby reducing a cytokine in the subject.

US Pat. No. 10,688,064

METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING TISSUE CALCIFICATION

Epizon Pharma, Inc., New...

1. A method of preventing, slowing the progression of, arresting and/or reversing tissue calcification in a pre-diabetic human subject or a human subject with diabetes, chronic kidney disease or a combination thereof, and in need thereof, the method comprising administering to the subject at least 10 mg of substantially pure menaquinone-7 (MK-7) and/or menaquinol-7 (MKH2-7) per day, thereby to prevent, slow the progression of, and/or arrest tissue calcification in the subject, whereupon the administration of the MK-7 and/or MKH2-7 increases a plasma level of Fetuin A relative to the plasma level of Fetuin A prior to administration.

US Pat. No. 10,688,062

ANALGESIC COMPOSITIONS

Vapogenix, Inc., Houston...

1. An uniform composition comprising a halogenated volatile compound and a poloxamer,wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof, and
wherein the composition is uniform.

US Pat. No. 10,688,058

MUCO-ADHESIVE, CONTROLLED RELEASE FORMULATIONS OF LEVODOPA AND/OR ESTERS OF LEVODOPA AND USES THEREOF

Impax Laboratories, LLC, ...

1. A method for treating Parkinson's disease or primary parkinsonism comprising orally administering a multiparticulate formulation to a human patient two, three or four times a day wherein the multiparticulate formulation comprises:(a) a plurality of controlled release particles comprising: i) a core comprising levodopa, optionally carbidopa, and at least one pharmaceutically acceptable excipient, ii) a muco-adhesive layer or coating surrounding the core wherein the muco-adhesive layer comprises at least one muco-adhesive polymer; and iii) an enteric layer or coating surrounding the muco-adhesive layer or coating wherein the enteric layer or coating comprises at least one enteric polymer;
(b) an immediate release component comprising levodopa and optionally carbidopa andwherein the controlled release particles are formulated as a mini-tablet, bead, or granule and the multiparticulate formulation produces an in vivo levodopa plasma profile following oral administration of the multiparticulate formulation to a human subject under fasting conditions comprising:(a) a levodopa plasma concentration corresponding to maximum levodopa plasma concentration (Cmax) occurring within 6 hours after administration of the multiparticulate formulation;
(b) a time to reach 50% Cmax of less than one hour after administration of the multiparticulate formulation; and
(c) wherein the in vivo plasma level of levodopa is maintained at 50% Cmax or above for at least 5.0 hours after administration of the multiparticulate formulation.

US Pat. No. 10,688,044

EPINEPHRINE SPRAY FORMULATIONS

Bryn Pharma, LLC, Raleig...

1. A method of administering a pharmaceutical solution, comprising delivering a spray of the pharmaceutical solution from a device into a nostril of a subject in need thereof in a manner that delivers the pharmaceutical solution in a round spray plume with an ovality ratio less than about 1.4 when measured at a distance of from about 1 to about 10 cm from the device, wherein:(i) the device is adapted for nasal delivery;
(ii) a volume of from about 20 ?L to about 250 ?L of spray is delivered; and
(iii) the pharmaceutical solution comprises from about 0.5 mg to about 100 mg of epinephrine, or a pharmaceutically acceptable salt thereof, and the pharmaceutical solution further comprises from about 0.01% to about 0.1% (w/w) of sodium bisulfite or sodium metabisulfite, and about 1% (w/w) diethylene glycol monoethyl ether.

US Pat. No. 10,688,043

PERSONAL LUBRICANTS COMPRISING LAMBDA-CARRAGEENAN

1. A pourable antiviral lubricous composition, useful during or associated with sexual activity, formed by a process comprising the steps of:(a) providing a carrageenan powder comprising carrageenan, the carrageenan comprising about 90% by weight ?-carrageenan and about 10% by weight of K-carrageenan;
(b) combining, while mixing, the carrageenan powder with an aqueous solution comprising propylene glycol, to form an aqueous carrageenan suspension;
(c) adding one or more sweeteners to the aqueous carrageenan suspension;
(d) heating the aqueous carrageenan suspension up to a temperature of at least 70° C. and up to about 75° C.;
(e) mixing the heated aqueous carrageenan suspension for a time sufficient to form an aqueous homogenous solution;
(f) cooling the aqueous homogeneous solution to a temperature of less than about 30° C.; and
(g) mixing one or more pH-adjusting agents and one or more preservatives into the cooled aqueous homogeneous solution, sufficient to adjust the antiviral lubricous composition to a pH of about 3.5 to about 7.0, thereby forming the antiviral lubricous composition;
wherein:
(i) the antiviral lubricous composition consists essentially of about 1.5% to about 1.7% by weight of carrageenan, about 4.0% to about 4.5% by weight of propylene glycol, up to about 0.5% by weight of the one or more sweeteners, up to about 1% by weight of the one or more preservatives, and about 0.01% to about 1% by weight of one or more pH-adjusting agents, the balance water;
(ii) the antiviral lubricous composition has a viscosity of at least about 2,000 cP, up to about 3,000 cP; and
(iii) the antiviral lubricous composition has a turbidity that is less than or equal to about 25 Nephelometric Turbidity Units (NTU).

US Pat. No. 10,688,041

COMPOSITIONS AND METHODS UTILIZING POLY(VINYL ALCOHOL) AND/OR OTHER POLYMERS THAT AID PARTICLE TRANSPORT IN MUCUS

Kala Pharmaceuticals, Inc...

1. An ophthalmic composition comprising:(a) a plurality of mucus-penetrating coated particles,
wherein each of the coated particles comprises:
(i) a core particle comprising a pharmaceutical agent or a salt thereof, wherein the pharmaceutical agent constitutes at least about 80 wt % of the core particle; and
(ii) a mucus penetration-enhancing coating comprising a surface-altering agent surrounding the core particle, wherein the surface-altering agent comprises a poly(vinyl alcohol) (PVA) polymer having pendant hydroxyl groups on the backbone of the PVA polymer, the PVA polymer having a molecular weight of at least about 1 kDa and less than or equal to about 1000 kDa, wherein the hydrolysis level of the PVA polymer is at least about 30% and less than about 95%, and
(b) one or more pharmaceutically acceptable excipients or carriers;
wherein the coated particles have an increased mobility in human mucus relative to uncoated particles;
wherein the coated particles have an average size of less than 1 ?m; and
wherein the ophthalmic composition is configured for delivery to an eye.

US Pat. No. 10,688,039

SCAVENGING DISSOLVED OXYGEN VIA ACOUSTIC DROPLET VAPORIZATION

University of Cincinnati,...

1. A method of treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient, the method comprising: administering a composition comprising a perfluorocarbon (PFC) droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.

US Pat. No. 10,688,033

HAIR COLOURATION FORMULATION

Noxell Corporation, Hunt...

1. A polymeric hair colouring formulation, comprising:at least two different chromophores and/or fluorophores linked to polymer(s), wherein the formulation comprises at least one of:
(a) a mixture of at least a first cationic coloured polymer and a second cationic coloured polymer,
wherein the first cationic coloured polymer comprises a first cationic polymer-backbone to which at least a first chromophore and/or a first fluorophore is linked, and
wherein the second cationic coloured polymer comprises a second cationic polymer-backbone to which at least a second chromophore and/or a second fluorophore different to the first chromophore and/or fluorophore is linked; and
(b) a mixture of at least a first anionic coloured polymer and a second anionic coloured polymer,
wherein the first anionic coloured polymer comprises a first anionic polymer-backbone to which at least a first chromophore and/or a first fluorophore is linked, and
wherein the second anionic coloured polymer comprises a second anionic polymer-backbone to which at least a second chromophore and/or a second fluorophore different to the first chromophore and/or fluorophore is linkedandoptionally one or more uncoloured polymer(s).

US Pat. No. 10,688,032

EMULSIONS HAVING UV SUNSCREEN FACTORS AND CARNOSINES

Symrise AG, Holzminden (...

1. A method for stabilizing an emulsion, comprising adding to the emulsion, a carnosine compound of formula (I)
wherein R1 represents H or CH3 and R2 represents H or COOH, or salts thereof.

US Pat. No. 10,688,023

TABLET PRESS

Gamlen Tableting Limited,...

1. A tablet press comprising:a base;
a press member separated from the base by a spacer, the base comprising a die for receiving a powder in use, the die having a die floor opposing the press member, wherein the spacer depends from the base and is moveable into and away from the base under the control of an electric motor such that the press member is reversibly actuable towards and away from the die floor between an at-rest condition in which the press member is spaced from the die and an actuated condition in which the press member is located in the die and applies a load to a powder therein;
an actuator;
a load sensor arranged in the force path between the actuator and press member for determining a compacting load applied by the press member to the powder in the die;
a digital encoder for the electric motor;
an electronic controller for controlling the angular position of the motor automatically according to an open or closed feedback loop based upon a sensed position of the press member relative to the die floor and the compacting load applied by the press member.

US Pat. No. 10,688,022

PRESSURE-REGULATING VIAL ADAPTORS

ICU Medical, Inc., San C...

1. A vial adapter comprising:a housing configured to couple with a vial having a septum;
a piercing member configured to be inserted through the septum of the vial;
an access channel configured to convey medical fluid;
a regulator channel configured to convey regulating fluid;
a check valve configured to permit ambient air to enter the regulator channel;
a reservoir comprising a first flexible side and a second flexible side, the reservoir configured to receive regulating fluid from the regulator channel; and
a two-way valve positioned in the regulator channel, the two-way valve configured to allow regulating fluid to flow:
in a first direction and into the reservoir at a first cracking pressure; and
in a second direction and out of the reservoir at a second cracking pressure, the second cracking pressure being less than the first cracking pressure.

US Pat. No. 10,688,021

AUTOMATED DRUG PREPARATION APPARATUS INCLUDING AUTOMATED DRUG RECONSTITUTION

Baxter Corporation Englew...

1. An automated system for use in the preparation of medication orders, comprising:at least one database configured for storing:
a plurality of medication orders, and
identifying information for each of a plurality of medication sources;
a computer controller, in communication with the at least one database, wherein for preparation of each given order of the plurality of medication orders the computer controller is configured to:
access automatically the identifying information for at least one of the plurality of medication sources corresponding with a respective given order, and
compare automatically identifying information read from a corresponding selected medication source to the identifying information for the at least one of the plurality of medication sources corresponding with the respective given order;
a camera configured and arranged to obtain an image of the corresponding selected medication source; and
a label printer, in communication with the computer controller, wherein for each given order of the plurality of medication orders the label printer is operable to print a corresponding label for application to a corresponding delivery device for containing medication corresponding with the respective given order of the plurality of medication orders,
wherein for each given order of the plurality of medication orders the corresponding delivery device is one of a syringe and a bag, and
wherein each of the plurality of medication sources is one of a vial containing a medication and a bag containing a fluid medication.

US Pat. No. 10,688,020

SEPTUM THAT DECONTAMINATES BY INTERACTION WITH PENETRATING ELEMENT

DR. PY INSTITUTE LLC, Ne...

23. A method comprising:penetrating a septum with a needle or other penetrating element, the septum comprising:
a peripheral portion extending about a periphery of the septum;
a penetration portion, having an exterior surface and an interior surface and extending between the exterior and interior surfaces, that is spaced radially inwardly of the peripheral portion and is penetrable by the needle or other penetrating element;
a flex portion located radially between the penetration portion and the peripheral portion; and
an increased thickness portion extending radially between the flex portion and the penetration portion, and defining an increased thickness between the exterior and interior surfaces relative to the flex portion, wherein the flex portion is flexible inwardly relative to the peripheral portion during penetration of the penetration portion by a needle or other penetrating element;
wherein the septum is configured to decontaminate a needle or other penetrating element during penetration of the penetration portion therewith by interaction between the septum and said needle or other penetrating element; and
during said penetrating step, decontaminating the needle or other penetrating element by interaction between the septum and said needle or other penetrating element.

US Pat. No. 10,688,019

CHEST COMPRESSION SYSTEM AND METHOD

Zoll Circulation, Inc., ...

1. A system for determining cardiopulmonary resuscitation (CPR)-induced chest compression depth achieved during the application of repeated chest compressions to a patient's chest, said system comprising:a first motion sensor operable to generate motion signals corresponding to motion in a first coordinate frame defined by a first set of axes;
a second motion sensor operable to generate motion signals corresponding to motion in a second coordinate frame defined by a second set of axes; and
a control system operable to receive the motion signals from the first motion sensor and the second motion sensor, rotate the motion signals from the first motion sensor into the second coordinate frame to obtain rotated motion signals corresponding to the motion signals from the first motion sensor,
combine said rotated motion signals with the motion signals from the second motion sensor to obtain net motion signals, in the second coordinate frame, corresponding to the motion of the first motion sensor relative to the motion of the second motion sensor,
determine the displacement of the first motion sensor, and to generate an output indicative of said displacement; wherein
the control system rotates the motion signals from the first motion sensor into the second coordinate frame by applying a rotation matrix to the motion signals from the first motion sensor.

US Pat. No. 10,688,018

APPARATUS FOR CARDIOPULMONARY MASSAGING AND/OR RESUSCITATION

1. An apparatus for cardiopulmonary massaging and/or resuscitation, with a massaging device having a plunger that is reversibly movable in an actuating direction, can be actuated by a drive and is placeable on the ribcage of a patient in a target contact zone, wherein the plunger is securable to the ribcage of the patient in the target contact zone and is mounted in such a way as to be freely movable in a plane running transversely to the actuating direction at least during an unloaded state between two massaging strokes, wherein the plunger is secured or securable to a holder attachable to the ribcage of the patient, wherein the holder is designed as a holding pad that can be stuck onto the ribcage with an adhesive layer, and wherein the massaging device has at least one lockable and unlockable hinge, repositionable about an axis running parallel to the actuating device, and a lock, actuated by a force sensor and/or path sensor, to prevent transverse mobility of the plunger during a massaging stroke and to lock the at least one hinge.

US Pat. No. 10,688,017

CHEST COMPRESSION DEVICES FOR USE WITH IMAGING SYSTEMS, AND METHODS OF USE OF CHEST COMPRESSION DEVICES WITH IMAGING SYSTEMS

ZOLL CIRCULATION, INC., ...

1. A device for compressing a chest of a patient while imaging the patient in an imaging system, said imaging system defining an imaging area which encompasses a portion of the patient's abdomen, thorax, neck and/or head, said device comprising:a platform adapted to be disposed beneath the patient's thorax while the patient is disposed within a gantry of the imaging system;
a belt operably connected to the platform and adapted to extend at least partially around the chest of the patient, the belt comprising
a load distributing portion adapted to extend across the patient's chest, and
tensioning portions extending from the load distributing portion, and posteriorly relative to the patient;
a first set of spindles fixed on the platform so as to be disposed laterally and aligned inferiorly/superiorly relative to the patient to guide the tensioning portions on either side of the patient's body from an anterior/posterior direction to a lateral/medial direction;
a second set of spindles fixed on the platform and disposed medially and aligned anteriorly/posteriorly relative to the patient to guide the tensioning portions from the lateral/medial direction; and
a rotary actuator aligned to pull the tensioning portions of the belt along the superior/inferior direction, the rotary actuator disposed relative to the load distributing portion of the belt such that the rotary actuator is located outside of the imaging area when the patient is disposed on the platform with the belt extending around the chest of the patient.

US Pat. No. 10,688,016

ANALGESIC IMPLANT DEVICE AND SYSTEM

Asfora IP, LLC, Sioux Fa...

1. A method for treating back pain, the method comprising mounting a vibrating implant device between two adjacent spinous processes of a vertebral column by pressing, with the vibrating implant device, both a first lateral side of the two adjacent spinous processes and a second lateral side of the two adjacent spinous processes that is opposite the first lateral side, wherein the vibrating implant device is configured to deliver a vibration to a region of the vertebral column that is between the two adjacent spinous processes to treat the back pain,wherein the vibrating implant device comprises:
a case comprising a bearing structure that is pressed against the first lateral side of the two adjacent spinous processes of the vertebral column and a tissue engaging structure extending and elongated from the bearing structure; wherein the bearing structure is located toward a first end of the case; and
a bearing member mountable onto a second end of the case defined by the tissue engaging structure and comprising a bearing surface that is pressed against the second lateral side of the two adjacent spinous processes of the vertebral column.

US Pat. No. 10,688,015

APPARATUS FOR SIMULATING SEXUAL MOTION

MB Technologies, LLC, Sa...

1. A cover for an apparatus configured to produce a motion; the cover comprising:a) a shaft;
b) a body in form of two arms that extend on each side of the shaft; and
c) a cavity all around the shaft, and in between the shaft and the body;wherein the shaft is movable in relation to the body when a force is applied to the shaft from a bottom of the cover.

US Pat. No. 10,688,014

MASSAGE APPARATUS WITH KNUCKLE-SHAPED NODES

1. A massage apparatus comprising:a spherical-shaped body defining a first face and a second face opposite the first face;
a first row of protruding nodes located on the first face; and wherein the protruding nodes of the first row vary in height in a first direction; and
a second row of protruding nodes located on the first face and parallel to the first row; and
wherein the second face is node-less; and wherein the protruding nodes of the first row increase in height sequentially in a first direction; and
wherein each of said nodes comprises a conical shape including an enlarged base and an oval-shaped top smaller in diameter than the base.

US Pat. No. 10,688,013

PROGRESSIVE MOBILITY AID DEVICE

1. A progressive mobility aid device comprising:a front-left leg assembly;
a front-right leg assembly;
a rear-left leg assembly;
a rear-right leg assembly;
a lower left sidebar including a first end and a second end, where the lower left sidebar is pivotably coupled to the front-left leg assembly proximate to the first end and pivotably coupled to the rear-left leg assembly proximate to the second end;
a lower right sidebar including a first end and a second end, where the lower right sidebar is pivotably coupled to the front-right leg assembly proximate to the first end and pivotably coupled to the rear-right leg assembly proximate to the second end;
an upper left sidebar including a first end and a second end, where the upper left sidebar is pivotably coupled to the front-left leg assembly proximate to the first end and pivotably coupled to the rear-left leg assembly proximate to the second end;
an upper right sidebar including a first end and a second end, where the upper right sidebar is pivotably coupled to the front-right leg assembly proximate to the first end and pivotably coupled to the rear-right leg assembly proximate to the second end;
a rear-left housing coupled to the rear-left leg assembly and including a first mechanical stop, wherein a portion of the rear-left housing forms a left handle;
a rear-right housing coupled to the rear-right leg assembly and including a second mechanical stop, wherein a portion of the rear-right housing forms a right handle;
a left clutch assembly positioned within the rear-left housing, the left clutch assembly comprising:
a left clutch sprocket that includes a set of left clutch sprocket teeth;
a left clutch block that includes a set of left clutch block teeth;
a left clutch rod;
a left clutch spring; and
a left clutch lever; and
a right clutch assembly positioned within the rear-right housing, the right clutch assembly comprising:
a right clutch sprocket that includes a set of right clutch sprocket teeth;
a right clutch block that includes a set of right clutch block teeth;
a right clutch rod;
a right clutch spring; and
a right clutch lever.

US Pat. No. 10,688,012

SINGLE TUBE CRUTCH AND METHOD OF NESTING AND PACKAGING THE SAME

Medline Industries, Inc.,...

1. A method, comprising:providing a first crutch and a second crutch, each crutch comprising:
a single tube support comprising an upper leg and a lower leg that is fully insertable into the upper leg in a collapsed position such that only a slip-resistant tip is exposed;
an underarm support coupled to the upper leg;
a grip assembly configured to translate along the upper leg between a usage position and a stowed position;
a plurality of grip assembly apertures disposed along the upper leg, each of which the grip assembly may align when in the usage position; and
a plurality of leg insertion apertures, a subset of which a push button of the lower leg may align to extend distally from the upper leg;
the plurality of leg insertion apertures offset from the plurality of grip assembly apertures by an angle of about ninety degrees;
placing the first crutch and the second crutch in the collapsed position;
placing the grip assembly of the first crutch and the second crutch in the stowed position; and
rotating the second crutch 180-degrees out of phase with the first crutch to form a nested configuration of the first crutch and the second crutch.

US Pat. No. 10,688,011

FOLDABLE WALKER

HOMECARE ENTERPRISE CO., ...

1. A foldable walker comprising:a connecting rod,
two flipping members, and
two side frames;
wherein:
opposing ends of the connecting rod have a respective vertical sleeve, an end of each vertical sleeve having a C-shaped plate with at least one positioning aperture, the C-shaped plate defining an opening opposite the positioning aperture;
the two flipping members each have a respective base and a respective knob, each base having an assembly hole disposed above the C-shaped plate of the respective vertical sleeve and having a containing hole, an elastic member and a limiting shaft disposed in the containing hole and corresponding to the positioning aperture, each base further comprising a protrusion corresponding to the respective opening;
a rear end of each limiting shaft engages with the respective positioning aperture;
each knob has a through aperture and a grip, an inclined portion disposed between the through aperture and the grip, the through aperture of each knob aligned with the respective assembly hole of the base, the inclined portion having a slot accepting the limiting shaft, the limiting shaft connected to a slidable member, the slidable member slidably disposed on the inclined portion such that rotation of the knob causes the slidable member to slide along the inclined portion to raise or lower the limiting shaft to disengage or engage the rear end of the limiting shaft with the respective positioning aperture; and
the two side frames respectively have a front leg and a rear leg to form a U-shape, each front leg disposed through a respective vertical sleeve of the connecting rod and the respective flipping member to combine the base of the flipping member with the front leg.

US Pat. No. 10,688,010

ADJUSTING ASSEMBLY AND EXOSKELETON ROBOT COMPRISING THE SAME

FREE BIONICS TAIWAN INC.,...

1. An adjusting assembly for an exoskeleton robot, the adjusting assembly comprising:a first plate, including at least one pin aligned in a first direction;
a second plate pivotably connected to the first plate via a first shaft; and
a second shaft extending in parallel with the first shaft in the first direction, and including a body and at least one recess, the second shaft configured to rotate to a first position to accommodate the at least one pin in the at least one recess, and to a second position to release the at least one pin from the at least one recess,
wherein at the first position the second plate is blocked from rotation about the first shaft by the body, and at the second position the second plate is allowed to rotate about the first shaft.

US Pat. No. 10,688,009

MOTION ASSISTANCE APPARATUS

Samsung Electronics Co., ...

1. A motion assistance apparatus comprising:a power distributor including a first output terminal, a second output terminal and a connecting member configured to connect the first output terminal and the second output terminal;
a proximal support configured to support a proximal part of a user;
a distal support configured to support a distal part of the user;
a rotary frame connected to the distal support and connected to the second output terminal of the power distributor via a connecting rod; and
a sliding frame connected to the rotary frame and to the first output terminal of the power distributor, the sliding frame configured to perform a translational motion relative to the proximal support to rotate the rotary frame such that the rotary frame is configured to simultaneously perform the translational motion and a rotational motion relative to the proximal support.

US Pat. No. 10,688,008

PHYSICAL THERAPY SYSTEM

One80 Physical Therapy, P...

1. A method for treating a target muscle having weak muscle contraction output force, comprising:identifying said target muscle having said weak muscle contraction output force;
measuring muscle contraction output force of said target muscle with a dynamometer prior to treatment of said target muscle;
subsequent to measuring said muscle contraction output force of said target muscle, treating the target muscle with a treatment, comprising:
identifying corresponding origin and attachment of said target muscle;
applying a first amount of pressure to only a target muscle belly first end a distance from said origin of said target muscle along a target muscle belly longitudinal axis with a first pressure-generating member; and
applying a second amount of pressure to only a target muscle belly second end a distance from said attachment of said target muscle along said target muscle belly longitudinal axis with a second pressure-generating member; and
subsequent to treating said target muscle with said treatment, measuring said muscle contraction output force of said target muscle with said dynamometer,
wherein said treatment to the target muscle results in an increase in said muscle contraction output force as measured with said dynamometer.

US Pat. No. 10,688,007

COMPRESSION DEVICE

Recovery Force, LLC, Fis...

1. A device comprising:a compression device for applying controllable compression to a portion of the anatomy of a user integrated into the device, the compression device including;
a plurality of shape memory wires integrated into the device to apply compression to a portion of the wearer's body wearing the device upon actuation of the plurality of wires;
a pre-tensioning apparatus including an elastic element connected to each of the plurality of shape memory wires and integrated into the device such that the elastic element substantially encircles the portion of the anatomy, and such that the pre-tensioning apparatus applies an initial tension to the plurality of shape-memory wires; and
a controller configured to selectively actuate one or more of the plurality of shape-memory wires to reduce the effective length of the wires, to thereby apply pressure to the portion of the wearer's body through the shape memory wires and the elastic element for the associated shape memory wire.

US Pat. No. 10,688,006

STUFFED ANIMAL PET URN

1. A method for producing a stuffed animal pet urn, the method comprising:receiving a plurality of photographic viewpoints of an actual animal and/or pet;
creating a three-dimensional model based on the received plurality of photographic viewpoints, the three-dimensional model including measurement information of the actual animal and/or pet, wherein creating the three-dimensional model comprises:
acquiring measurement information of the pet body from the plurality of photographic viewpoints of the pet body; and
drawing two or more patterns based on the measurement information; and
producing a stuffed animal pet urn based on the three-dimensional model, wherein the stuff animal pet urn comprises:
a head made in accordance with measurement information acquired from an actual animal and/or pet;
a body attached to the head and made in accordance with the measurement information;
at least two or more legs attached to the body and made in accordance with the measurement information;
a tail attached to the body and made in accordance with the measurement information; and
an internal hollow compartment, wherein the head, the body, the at least two or more legs and the tail are superimposed with a fur pattern and stuffed with a stuffing agent made in accordance with the measurement information, and wherein the internal hollow compartment is configured to secure and retain an object, and
wherein producing the stuffed animal pet urn based on the three-dimensional model comprises:
printing the two or more patterns;
pinning the two or more patterns on a fabric;
tracing the two or more patterns pinned on the fabric;
cutting the traced two or more patterns pinned on the fabric;
sewing the cut two or more patterns to the pinned fabric; and
stuffing the cut two or more patterns in areas around the hollow internal compartment of the pet body.

US Pat. No. 10,688,005

CREMATION STORAGE DEVICE AND SYSTEM, METHODS OF FORMING CREMATION STORAGE DEVICE AND SYSTEM, AND METHODS OF OPERATION OF CREMATION STORAGE DEVICE AND SYSTEM

1. A repository system for storing cremains, comprising:a first elongated capsule adapted to store cremains coupled to a first repository panel, the first elongated capsule extending in a first axis of extension;
a second elongated capsule adapted to store cremains coupled to the first repository panel, the second elongated capsule extending in a second axis of extension; and
a third elongated capsule adapted to store cremains coupled to a second repository panel, the third elongated capsule extending in a third axis of extension;
wherein a portion of the third elongated capsule is positioned between a portion of the first elongated capsule and a portion of the second elongated capsule.

US Pat. No. 10,688,004

OVERLAY SUPPORT PAD FOR MEDICAL BEAN BAG DEVICE

Prime Medical, LLC, Knox...

1. A foam overlay pad configured to be removably placed on a separately formed patient positioning bean bag device to support a patient on an operating table, the foam overlay pad comprising:a top surface configured to contact and conform with the patient's body when the patient is placed on the foam overlay pad; and
a bottom surface configured to contact and conform with a top surface of the bean bag device such that portions of the bottom surface are configured to bridge and fill gaps formed between rigid protuberances in the top surface of the bean bag device when the patient is placed on the foam overlay pad
wherein the bean bag device is separately formed from the foam overlay pad, and
wherein the foam overlay pad is removably placeable on the top surface of the bean bag device, and
wherein the foam overlay pad is configured such that when the bottom surface of the foam overlay pad contacts a raised portion of the top surface of the bean bag device, a cellular structure of the foam overlay pad allows portions of the bottom surface of the foam overlay pad to be drawn down into the gaps of the bean bag device to form a smooth and continuous interface, such that the bottom surface of the foam overlay pad mates continuously with the top surface of the beam bag so as to be merged into the gaps and the protuberances of the bean bag device such that the bottom surface of the overlay pad and the top surface of the bean bag device are melded together.

US Pat. No. 10,688,003

MICRO-ENVIRONMENT MODULE ARCHITECTURE FOR INFANT CARE DEVICES

General Electric Company,...

1. An infant care station that creates a micro-environment for an infant patient, comprising:a data repository configured to receive and store sensor input signals in a standard data format;
a universal interface bus including a DC main power supply line, a low voltage standby power supply line, a high priority communication bus and a low priority communication bus;
an interface module connected to the universal interface bus and including a display and a plurality of input ports, wherein the interface module communicates with the data repository through the universal interface bus to retrieve the sensor input signals;
a plurality of sensor module in communication with the data repository and the interface module over the universal interface bus, the plurality of sensor modules each receiving sensor input signals from at least one sensor positioned to detect at least one parameter related to the infant patient or the micro-environment, wherein each of the plurality of the sensor module can be separately connected and disconnected from the universal interface bus and each of the sensor modules configures the sensor input signals for storage in the standard data format; and
a master module in communication with the plurality of sensor module, the data repository and the interface module over the universal interface bus, the master module being operable to retrieve the sensor input signals from the data repository and operable to control at least one power output to control at least one power device of the infant care station.

US Pat. No. 10,688,002

COMBINED MOBILE CART FOR SICK AND WOUNDED

1. A combined mobile cart for a sick or wounded, comprising a mobile cart and a mobile stretcher, wherein the mobile cart comprises a main body frame (14), a left retractable track mechanism (6), a right retractable track mechanism (7), a lifting and translating mechanism (1), and an automatic movable weight-balancing mechanism (18); the left retractable track mechanism (6) and the right retractable track mechanism (7) are arranged on a top of the main body frame (14), and a supporting layer (15) is arranged in a middle of the main body frame (14), the automatic movable weight-balancing mechanism (18) is arranged at a bottom of the main body frame (14), and universal casters (16), a self-contained power supply and a PLC system (30) are arranged under the bottom of the main body frame (14); the left retractable track mechanism (6) and the right retractable track mechanism (7) are respectively arranged at a left side and a right side on the top of the main body frame (14), and the lifting and translating mechanism is formed by fixedly assembling a left case body (2) and a right case body (3) via a first linkage rod (8) and a second linkage rod (9) as well as a first interval-controlling rod (58) and a second interval-controlling rod (59), and supported by left and right case-frame travelling wheels (35) to run on tracks of a first fixed track (10), a second fixed track (11), a first retractable track (4) and a second retractable track (5) on the top of the main body frame (14), so as to reciprocate along an axial line when the retractable tracks deploy; lifting ropes (43) are arranged below the left case body (2) and the right case body (3) of the lifting and translating mechanism, and suspension tools (12) are connected with the lifting ropes (43) for vertically lifting and vertically moving the mobile stretcher; the automatic movable weight-balancing mechanism (18) is arranged at the bottom of the main body frame (14), and the automatic movable weight-balancing mechanism (18) is configured to move outwards under driving of a drive weight-balancing block (21) so as to balance a force moment in lifting when the lifting and translating mechanism (1) is moved outwards to a lifting position, and configured to move towards the inside of the main body frame under the driving of the drive weight-balancing block (21) when the lifting and translating mechanism (1) completes vertical lifting and inward movement, so as to reduce a space to facilitate the movement of the mobile cart; the self-contained power supply for supplying power to drive the mobile cart and the PLC system (30) for operation controlling are arranged at the bottom of the main body frame (14); the mobile stretcher (13) adopts a shovel type mobile stretcher for the sick or wounded, a simple mobile stretcher for the sick or wounded, or an easy-to-move mobile stretcher; and the mobile stretcher (13) is arranged below the left case body (2) and the right case body (3) of the lifting and translating mechanism of the mobile cart, and the suspension tools (12) arranged below the left case body (2) and the right case body (3) of the lifting and translating mechanism (1) is configured to lift the mobile stretcher (13).

US Pat. No. 10,688,001

STANDING MOTION ASSIST SYSTEM, METHOD FOR CONTROLLING STANDING MOTION ASSIST SYSTEM, RECORDING MEDIUM, AND ROBOT

PANASONIC INTELLECTUAL PR...

1. A standing motion assist system for assisting a care-receiver in performing a standing motion, comprising:a care belt including
a holding mechanism including a holder support member and a holder that holds a back and both armpits of the care-receiver, the holder support member including a front support member and a rear support member, the rear support member including an openable and closeable attachment portion configured to facilitate positioning of the care-receiver within the care belt so that the care-receiver may enter the care belt when the rear support member is in an open position and so that a circumferential portion of the care-receiver is surrounded by the holder support member when the rear support member is in a closed position, and
a connector that is connected to the holding mechanism at a position in front of the care-receiver when the care-receiver is positioned within the care belt;
a rotational force applying mechanism that is connected to the holding mechanism and that rotates a front part of the holder upward and a rear part of the holder downward about a rotation axis being provided between the front support member which the front part is attached to and the rear support member which the rear part is attached to, a length between the connector and the front support member being smaller than a length between the connector and the rear support member, wherein, when the care-receiver is positioned within the care belt, the front support member is situated in front of the care-receiver and the rear support member is situated behind the care-receiver;
a traction mechanism that is connected to the connector and that pulls the connector; and
a controller that controls a rotational motion of the rotational force applying mechanism and a pulling motion of the traction mechanism so that, after the traction mechanism has started the pulling motion, the rotational force applying mechanism rotates the front part of the holder upward and the rear part of the holder downward at the same time as the traction mechanism pulls the connector forward and upward, thereby the care-receiver being pulled forward and upward, and subsequently the traction mechanism pulls the connector upward.

US Pat. No. 10,688,000

TREATMENT BODY MATS

1. A treatment mat, comprising:a mat material portion having an upper surface;
a pattern of openings extending into the mat material from the upper surface, each of the openings having a predetermined shape;
a solid matrix material within each of the openings, the solid matrix material being transparent, being formed to match the predetermined shape of the corresponding opening and comprising urethane rubber; and
one or more types of stones encased in the matrix material within each of the openings.

US Pat. No. 10,687,999

OBSTRUCTION DETECTION SYSTEM AND METHOD

Stryker Corporation, Kal...

1. A control system for controlling an actuator of a patient support, said control system comprising:a motor driver operably coupled to an electric motor, said motor driver configured to supply power via a supply output to the electric motor to drive the actuator;
a motor sensor configured to provide a motor sensor output indicative of a sensed characteristic of the power that is output from said supply output of said motor driver and supplied to the electric motor; and
a controller operably coupled to said motor sensor to obtain said motor sensor output, said controller configured to direct said motor driver to supply power to the electric motor to drive the actuator, wherein said controller is configured to detect a pinch event based on said motor sensor output.

US Pat. No. 10,687,998

BED APPARATUS

PARAMOUNT BED CO., LTD., ...

1. A bed apparatus including a plurality of bottoms placed on an upper frame thereof, one of the bottoms being a knee bottom for supporting a part of a user extending from hips of the user to the knees of the user, comprising:a tilting driver that can perform a tilting operation of the upper frame so as to create difference in height between a head side and a foot side of the upper frame and, at least, lower the foot side relative to the head side; and,
an operational state detector that detects that a knee bottom actuation assembly for raising and lowering the knee bottom is operable, wherein
the tilting driver performs the tilting operation when the knee bottom forms an angle of 0 degrees or greater relative to the ground.

US Pat. No. 10,687,997

ELEVATED HEIGHT WHEELCHAIR

Pride Mobility Products C...

1. A powered wheelchair comprising:a frame;
a lift mechanism supported by the frame:
a seat supported by the lift mechanism, the lift mechanism configured to move the seat from a lowered position to a raised position;
a pair of drive wheels;
at least one drive coupled to the frame and configured to apply a torque to at least one wheel of the pair of drive wheels;
an arm assembly including an arm member pivotably coupled to the frame;
a front wheel rotatably coupled to the arm member; and
an arm limiter assembly pivotably coupled to the frame and configured to move from a first configuration whereby the arm member is capable of pivoting relative to the frame through a first range of rotation that is uninhibited by the arm limiter assembly, to a second configuration whereby the arm member is capable of pivoting relative to the frame through a second range of rotation that is inhibited by the arm limiter assembly, wherein the second range of rotation is smaller than the first range of rotation;
whereby in a blocked configuration, the arm assembly and arm limiter assembly are configured to engage each other to block the arm limiter assembly from pivoting to the second configuration.

US Pat. No. 10,687,996

CARRIER ASSEMBLY FOR A WHEELED MOBILITY DEVICE

Steady Enterprises, LLC, ...

1. A carrier configured to carry a wheeled mobility device, the carrier comprising:an attachment link configured to be removably connected to a vehicle;
a base component fixedly connected to the attachment link;
a basket component fixedly connected to the base component; and
an upper bracket;
wherein the basket component and the upper bracket are configured to support the wheeled mobility device, and
wherein the basket component includes a metal frame and a curved mesh component, the curved mesh component having first and second ends connected to opposite sides of the metal frame.

US Pat. No. 10,687,995

FOLDED ABSORBENT SHEET PRODUCTS DISPENSER HAVING INTERCHANGEABLE DISPLAY FEATURE, AND METHODS OF USING AND MARKETING SAME

1. A dispenser for absorbent sheet products comprising:a plurality of walls defining an interior of the dispenser for enclosing a stack of the absorbent sheet products;
a plurality of tabs or rails connected to one of said plurality of walls,
wherein:
at least one of said plurality of walls has an opening configured to allow withdrawal of the absorbent sheet products, from said interior of the dispenser, one-by-one,
at least one of said plurality of walls is transparent and includes an interior surface partly defining said interior of the dispenser,
said plurality of tabs or rails extend directly from said interior surface and are configured to receive and retain a sheet of paper pressed against said interior surface, and
said plurality of tabs or rails are spaced from one another so as to define an area smaller than a total transparent area of said at least one transparent wall, to thereby permit viewing there through of a remaining quantity of absorbent sheet products in said interior of the dispenser.

US Pat. No. 10,687,994

ABSORBENT ARTICLE WITH MULTI-LAYER FOLDED ABSORBENT CORE

ATTENDS HEALTHCARE PRODUC...

1. An absorbent core comprising a longitudinally folded absorbent laminate, the longitudinally folded absorbent laminate comprising:an upper laminate layer;
a lower laminate layer; and
an absorbent layer positioned between the upper laminate layer and the lower laminate layer, the absorbent layer comprising greater than about 90 percent by weight super absorbent polymer (SAP);
wherein the longitudinally folded absorbent laminate is folded to form a longitudinally folded multi-layer absorbent laminate of at least five layers of laminate;
wherein the longitudinally folded multi-layer absorbent laminate has two lateral laminate sides and a width extending between the laminate sides, a first one of the layers spans the entirety of the width, a second one of the layers is disposed above the first layer and spans between 80 percent and 92 percent of the width, third and fourth layers are disposed between the first and second layers and each span less of the width than does the second layer, and a fifth layer is disposed between the third and fourth layers and spans less of the width than does at least one of the third and fourth layers; and
wherein laterally opposing portions of at least the second and third layers define a longitudinally-extending channel above at least the first layer.

US Pat. No. 10,687,993

ABSORBENT ARTICLE WITH INDICATED ABSORPTION ZONE

1. An absorbent hygiene article for placement in underwear having a longitudinal extension X and a transversal extension Y when in a flattened out configuration, said article comprising:a liquid permeable topsheet; a backsheet; and an absorbent core disposed between the topsheet and the backsheet forming an assembled article, said absorbent core having a core perimeter encircling the core in the X-Y-plane;
said article further having an article perimeter encircling the article in the X-Y plane, which article perimeter does not intersect with the absorbent core perimeter;
an edge area defined as the area outside of the absorbent core perimeter and inside of the article perimeter; and
an inner area inside of the absorbent core perimeter,
wherein:
said topsheet and said backsheet are joined together in the edge area;
said topsheet is of a translucent material and is provided with a colored pattern defining at least one background region having a background inherent color and at least one colored region having a first inherent color;
a first part of the colored regions having said first inherent color is located in the inner area and a second part of the colored regions having said first inherent color is located in the edge area;
a first part of the background region having said background inherent color is located in the inner area and a second part of the background region having said background inherent color is located in the edge area;
the topsheet-facing side of the backsheet has a second inherent color; and
the first part of the background region has a color in the assembled article located in the inner area having a higher L*-value than a color in the assembled article of the second part of the background region located in the edge area, wherein the inherent color relates to color value measured on the topsheet or backsheet separately and the color in the assembled article relates to color value measured on the topsheet of the hygiene absorbent article as assembled.

US Pat. No. 10,687,992

FORMED FILM ACQUISITION DISTRIBUTION LAYER AND ABSORPTIVE DEVICE THEREWITH

TREDEGAR FILM PRODUCTS LL...

1. An absorptive device comprising:a topsheet;
a backsheet;
an absorbent core between the topsheet and the backsheet; and
an acquisition distribution layer between the topsheet and the absorbent core, the acquisition distribution layer comprising a formed film having a plurality of lands that contact a bottom surface of the topsheet and define a first irregular array of cells,
wherein the first irregular array of cells is comprised of a random variety of shapes forming no regular geometric shapes,
wherein the first irregular array of cells is configured to render the plurality of lands invisible to a naked eye when the absorptive device is viewed from above the topsheet, and
wherein at least some of the first irregular array of cells have an inscribed circle diameter of between about 800 microns and about 1400 microns.

US Pat. No. 10,687,991

ABSORBENT ARTICLE HAVING A LOTIONED TOPSHEET

1. An absorbent article comprising:A) a liquid impervious backsheet;
B) a liquid pervious topsheet joined to said backsheet, said topsheet having an inner surface oriented toward the interior of said absorbent article and an outer surface oriented toward the skin and hair of the wearer when said absorbent article is being worn, wherein at least a portion of said topsheet outer surface comprises an effective amount of a lotion coating having a HLB value below 7; and
C) an absorbent core positioned between said topsheet and said backsheet.

US Pat. No. 10,687,990

DISPOSABLE PANT-TYPE ABSORBENT ARTICLE

1. A disposable pant-type absorbent article, such as a pant diaper, a sanitary pant or incontinence pant, for an adult user, the absorbent article has a longitudinal direction and a transverse direction and comprises:a front body panel having a waist edge, a pair of leg edges and a pair of side edges,
a back body panel having waist edge, a pair of leg edges, a pair of side edges, a main section and a buttocks-covering section, and
an absorbent insert located mainly in a crotch portion of the absorbent article and connected to the front and back body panels for bridging the gap between the front and back body panels, wherein the absorbent insert comprises an absorbent core,
wherein the front and back body panels are also joined to each other at opposite side edges to at least partly define a waist-opening and a pair of leg-openings,
wherein the front body panel has a first at least partly elastic region extending along the leg edges of the front body panel, and a second at least partly elastic region located next to the first elastic region,
wherein the back body panel has a third elastic region extending at least partly over the buttocks-covering section of the back body panel,
wherein each of said elastic regions are elasticised by means of a plurality of elastic threads arranged substantially in the transverse direction across a major portion of the front or back body panel, and
wherein a side edge of the third elastic region overlaps in the longitudinal direction both a side edge of the first at least partly elastic region and part of a side edge of the second at least partly elastic region at the side seams,
wherein the back body panel further comprises a fifth elastic region extending along the waist edge of the back body panel and a sixth elastic region located between the third and fifth elastic regions,
wherein the length of the intervals in the longitudinal direction between neighbouring elastic threads is larger in the third elastic region than in the sixth elastic region, and
the length of the intervals in the longitudinal direction between neighbouring elastic threads is larger in the sixth elastic region than in the fifth elastic region.

US Pat. No. 10,687,989

DISPOSABLE WEARING ARTICLE

UNICHARM CORPORATION, Eh...

1. A disposable wearing article having a longitudinal direction and a lateral direction, the article comprising a chassis including a body facing surface, a non-body facing surface, a first waist region which is one of front and rear waist regions, a second waist region which is another of the front and rear waist regions and a crotch region extending between the first and second waist regions, an absorbent panel disposed on a side of the body facing surface of the chassis, and both side seams respectively coupling both side edges of the first waist region and both side edges of the second waist region, respectively, wherein:the absorbent panel includes an absorbent core extending to the front and rear waist regions centering on the crotch region, a pair of outer flaps extending longitudinally along both side edges of the absorbent core,
at least the first waist region of the first and second waist regions includes a waist elastic area which is elastically contractible in the lateral direction, and a pair of elastic strips which is elastically contractible in the lateral direction,
each of the pair of elastic strips has an inner fixing end fixed to the outer flap of the absorbent panel and an outer end fixing end fixed to the body facing surface of the chassis.

US Pat. No. 10,687,988

ABSORBENT ARTICLE HAVING CHARACTERISTIC WAIST ENDS

1. An absorbent article continuous in a longitudinal direction and a transverse direction, comprising a front belt portion, a back belt portion, and an absorbent main body, the center of the front belt portion is joined to a front waist panel of the absorbent main body, the center of the back belt portion is joined to a back waist panel of the absorbent main body, the front belt portion comprising a pair of front side panels, and the back belt portion comprising a pair of back side panels, and the respective front side panels of the front belt portion and the back side panels of the back belt portion are joined with each other, interior surface to interior surface, only at the respective transverse side edges to form side seams and a waist opening and two leg openings, each front belt portion and back belt portion having transversely continuous proximal and distal end edges, the proximal end edges being located closer than the distal end edges relative to the longitudinal center of the article, wherein:the front belt portion having a front waist end region (FWE) defined between a transversely extending front end edge of the absorbent main body and a front distal edge of the absorbent article;
the back belt portion having a back waist end region (BWE) defined between a transversely extending back end edge of the absorbent main body and a back distal edge of the absorbent article;
wherein the front and back distal end edges of the front and back belt portions are parallel to each other and wherein the front and back proximal end edges of the front and back belt portions are parallel to each other;
wherein the FWE and the BWE are not equal distances;
wherein the front belt portion comprises a front inner sheet and a front outer sheet, wherein a front end flap comprises the front outer sheet that is folded over the front distal edge of the absorbent article to form a front waist flap region;
wherein the front waist flap region comprises a plurality of elastic strands and an elastomeric film, wherein the elastic strands overlap the elastomeric film;
wherein the back belt portion comprises a back inner sheet and a back outer sheet, wherein a back end flap comprises the back outer sheet that is folded over the back distal edge of the absorbent article to form a back waist flap region;
wherein the back waist flap region comprises a plurality of elastic strands and an elastomeric film, wherein the elastic strands overlap the elastomeric film; and
wherein the elastomeric film in the front waist flap region and the plurality of elastic strands in the front waist flap region are separated by at least one of the front inner and outer sheets.

US Pat. No. 10,687,987

PROCESS FOR MAKING AN ABSORBENT ARTICLE COMPRISING A TOPSHEET/ACQUISITION LAYER LAMINATE

1. A process of making an absorbent article comprising the steps of:providing a liquid permeable topsheet web extending substantially continuously in a machine direction, the topsheet web having a first topsheet web surface lying substantially along a first topsheet web plane and second topsheet web surface, a liquid impermeable backsheet web extending substantially continuously in the machine direction, and an acquisition layer having left and right longitudinal edges a first acquisition layer surface and second acquisition layer surface lying substantially along a second acquisition layer plane;
aligning the topsheet web and the acquisition layer in a face to face relationship such that the second topsheet web surface is in contact with the first acquisition layer surface;
simultaneously mechanically deforming and combining the topsheet web together with the acquisition layer to form three-dimensional protrusions wherein the topsheet web and acquisition layer are nested together such that a majority of the three-dimensional protrusions formed in the topsheet web coincide with and fit together with a majority of the three-dimensional protrusions formed in the acquisition layer to provide a topsheet/acquisition layer laminate web having three-dimensional protrusions, wherein the topsheet/acquisition layer laminate having three dimensional protrusions is formed by interrupting the topsheet web or acquisition layer in the area of the three dimensional protrusions of the topsheet/acquisition layer laminate web such that three dimensional protrusions of the respective other non-interrupted topsheet web or acquisition layer at least partially fit together with the three dimensional protrusions of the interrupted topsheet web or acquisition layer;
wherein a width of the acquisition layer is less than a width of the topsheet web in a cross direction; the topsheet/acquisition layer laminate web having a first surface comprising the second surface of the acquisition layer; and
joining a portion of the backsheet web to a portion of the topsheet web of the topsheet/acquisition layer laminate web such that the first surface of the topsheet/acquisition layer laminate web is facing towards the backsheet web.

US Pat. No. 10,687,986

METHODS AND DEVICES FOR SKIN CLOSURE

Ethicon, Inc., Somervill...

1. A multi-segmented wound closure device having an overall length A?, a width B, an upper edge, a lower edge, a right-hand edge, and a left-hand edge with each segment of the device comprising:a wound closure strip having a length A, a width F, a wound-facing side, a top side, an upper edge and a lower edge, the wound-facing side comprising an adhesive applied over at least a portion of the wound facing side;
a release liner assembly detachably adhered to the wound closure strip by the adhesive, the release liner assembly consisting of a first section having a length A and a width E and a second section having a length A and a width D;
wherein the release liner assembly extends the full length A of each segment of the wound closure device and extends the full width B of the wound closure device, wherein the release liner assembly optionally forms a wound closure strip-free tab, wherein the wound closure strip-free tab has a width of G extending from the lower edge of the wound closure device to the lower edge of the wound closure strip;
wherein the width F of the wound closure strip is greater than the width E of the first section by a width H, where H is equal to length D minus width G; and
wherein the first section and the second section are separated from each other by a liner cut.

US Pat. No. 10,687,985

WOUND DRESSING

CONVATEC TECHNOLOGIES, IN...

1. A wound dressing comprising a non woven web of gel-forming fibers comprising longitudinal lines of stitches formed from thread and transverse lines of stitches formed from thread extending between at least two longitudinal lines of stitches to form a stitched column between the at least two longitudinal lines of stitches, wherein the transverse lines of stitches are finished at an edge of the at least two longitudinal lines of stitches resulting in at least one stitch free column between stitched columns.

US Pat. No. 10,687,984

WOUND DRESSING WITH A SENSOR

ABSORBEST AB, Kisa (SE)

1. A wound dressing comprising:an absorbent core;
a facing layer;
a backing layer made of a breathable non-woven fabric or a breathable film, wherein the absorbent core is located between the facing layer and the backing layer;
at least one sensor generating a sensor signal, wherein the sensor is arranged on a substrate of a plastic layer and the substrate is laminated onto an exterior surface of the backing layer; and
a display configured to receive the sensor signal from the at least one sensor and present data corresponding to the sensor signal, wherein the display is mounted to or integral with the wound dressing.

US Pat. No. 10,687,983

WOUND PAD

1. A wound pad, having a pad width, a pad length, and a pad thickness, wherein the pad thickness is less than the pad width and less than the pad length, comprising:a plurality of separable layers configured to be removed from each other, each layer having:
a layer thickness that is less than the pad thickness,
a first region connected to at least one adjacent layer, and
a second region unconnected from any adjacent layer,
wherein removal of a single one of the plurality of separable layers from the remainder of the plurality of separable layers reduces the pad thickness, and
wherein the plurality of separable layers are constructed from a single piece of material.

US Pat. No. 10,687,982

ONE-STEP TYMPANOSTOMY TUBE AND METHOD FOR INSERTING SAME

Domestic Legacy Limited P...

19. A method for inserting a tympanostomy tube into and for continued residence in a tympanic membrane having an interiorly facing surface in the tympanic cavity and an exteriorly facing surface in the auditory canal, comprising:providing a tympanostomy tube comprising a body including a first end portion, a second end portion, a central portion disposed between the first and second end portions, and an axially extending passageway having a first open end disposed adjacent the first end portion, and a second open end disposed adjacent the second end portion, and an axis extending between the first open end and second open end, the first end portion including a relatively enlarged diameter generally radially extending flange, the central portion including a reduced diameter portion sized for extending through and residing in tissue of the tympanic membrane, and the second end portion including at least first and second moveable legs having first ends coupled to the first end portion, and second ends, the second ends including sharpened toothed surfaces;
placing the toothed surfaces against the exteriorly facing surface of the tympanic membrane;
moving the tympanostomy tube in a back and forth direction to cause the toothed surfaces to engage the tympanic membrane and saw through the tympanic membrane; and
positioning the tympanostomy tube in the tympanic membrane so that the tympanostomy tube resides in the tympanic membrane with the passageway operable to conduct air between the tympanic cavity and the auditory canal.

US Pat. No. 10,687,981

HEADWORN SUPPORTS WITH PASSIVE VENTING AND REMOVABLE LENS

Oakley, Inc., Foothill R...

1. A headworn support comprising:a lens having a posterior surface adjacent to a face of a wearer when worn and an anterior surface opposite the posterior surface;
a frame comprising a plurality of contact points configured to contact the lens; and
a retention assembly attached to the frame, the retention assembly configured to secure the lens to the frame so that the lens contacts the frame at the plurality of contact points,
wherein, when the lens is secured in the headworn support, an upper edge of the lens and a lower edge of the frame are spaced apart between contact points to allow venting of the lens and a total, continuous chord length of the upper edge of the lens that is spaced apart from the frame is at least 20% of the total chord length of the upper edge of the lens,
wherein a posterior surface of the frame between contact points extends a protrusion distance beyond a posterior extension of the posterior surface of the lens, wherein the protrusion distance is less than or equal to about 4 mm.

US Pat. No. 10,687,980

SYSTEM AND METHOD OF IRIS-PUPIL CONTRAST ENHANCEMENT

AMO Development, LLC, Sa...

1. A system comprising:a processor;
a user input device; and
a memory storing computer readable instructions that when executed by the processor cause the system to perform a method of photoaltering a region of an eye having an iris and a pupil, comprising:
producing a first digital image of the eye, the first digital image having a first contrast between the iris and the pupil;
in response to a first user input received via the user input device, displaying the first digital image of the eye;
in response to a second user input received via the user input device, the second user input being different from the first user input, selectively increasing the first contrast between the iris and the pupil to a second contrast which is greater than the first contrast between the iris and the pupil;
displaying a second digital image of the eye, the second digital image having the second contrast between the iris and the pupil;
centrating the eye to align the eye with a pulsed laser beam based on the second contrast between the iris and the pupil; and
after centrating the eye, directing the pulsed laser beam to the region of the eye to photoalter the region of the eye.

US Pat. No. 10,687,979

ENHANCED VISUALLY DIRECTED PROCEDURES UNDER LOW AMBIENT LIGHT CONDITIONS

ALCON INC., Fribourg (CH...

1. A computer readable medium storing a set of computer instructions for performing an enhanced visually directed procedure under low ambient visible light on a patient's eye, the computer readable medium being non-transitory, the set of computer instructions being executable by a processor and comprising:acquiring, from at least one high resolution photosensor, at least one first real-time high resolution video signal representing at least one view of the eye in at least one wavelength of light outside of the wavelengths of visible light;
acquiring, from the at least one high resolution photosensor or a different high resolution photosensor, at least one second real-time high resolution video signal representing the at least one view of the eye inside of the wavelengths of visible light;
converting, via a processor, the at least one view corresponding to the at least one first real-time high resolution video signal at the at least one wavelength of light outside of the wavelengths of visible light into at least one wavelength of visible light;
displaying, via the processor, the at least one view corresponding to the at least one first real-time high resolution video signal including the at least one wavelength of visible light; and
wherein the processor causes the at least one high resolution photosensor to acquire the at least one first real-time high resolution video signal and the at least one second real-time high resolution video signal after light conditions are low enough such that a pupil of the eye does not constrict substantially from its maximum pupillary diameter.

US Pat. No. 10,687,978

DELIVERY SYSTEM AND METHOD OF USE FOR THE EYE

IVANTIS, INC., Irvine, C...

1. A system comprising:an ocular implant inserter configured to extend through an anterior chamber of an eye, the ocular implant inserter comprising:
a tool adapted to open an aperture in trabecular meshwork; and
an inserter tube comprising an interior space and a shaft slidably disposed in the interior space; and
an intraocular implant disposed in the interior space of the inserter tube, the intraocular implant comprising:
a proximal portion sized and shaped to reside within the anterior chamber, the proximal portion comprising a proximal opening;
a distal portion sized and shaped to reside within Schlemm's canal, the distal portion comprising a distal opening; and
a passageway extending in a straight line from the proximal opening to the distal opening,
the shaft being adapted to advance a distal end of the intraocular implant out of the interior space and through the aperture into Schlemm's canal.

US Pat. No. 10,687,977

DEVICE AND METHOD TO OPTIMIZE THE FORM AND FUNCTION OF A PESSARY

10. A process for modeling a pessary comprising the steps of:(i) inserting into a vagina a modeling device comprised of a matrix of expandable balloons that are substantially spherical and attachable to an outer surface of a hollow shaft at fixed openings on the outer surface, the matrix having at least two rows wherein each row is a circumferential ring around the outer surface of the shaft, the hollow shaft housing fill lines serving each fixed opening, such that the shaft supports the matrix of expandable balloons for vaginal insertion, and wherein each expandable balloon of the matrix of expandable balloons is coupled to a fill line for transferring fluid to the expandable balloon;
(ii) inflating each expandable balloon to a size by operating a fluid source that causes fluid to enter the fill line and thereby transfer fluid to the expandable balloon corresponding to said fill line;
(iii) measuring a fill volume for at least one expandable balloon; and
(iv) applying the fill volume for each expandable balloon to determine at least one dimension of at least one section of a pessary model.

US Pat. No. 10,687,975

METHOD AND SYSTEM TO FACILITATE THE GROWTH OF DESIRED BACTERIA IN A HUMAN'S MOUTH

1. A method to facilitate the growth of desired bacteria in a human's mouth by using a buccal bioadhesive strip, comprising:providing to an individual in need thereof a buccal bioadhesive strip, said strip having a first and second side, said first side having a surface comprising a pattern defined by a plurality of spaced apart features each having at least one microscale dimension and having at least one neighboring feature having a substantially different geometry, wherein an average spacing between adjacent ones of said features is between 0.5 and 5 micrometers in at least a portion of said surface, the second side having a bioadhesive that is adapted to bind to a mucosal membrane for at least 1 hour while inside a person's mouth, wherein said strip includes at least one encapsulated feature containing at least one bacteria that has one of a pathogenic or toxic element excised using a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system.

US Pat. No. 10,687,974

DEVICES FOR TREATING BRUXISM

SJS Group, LLC, Winona L...

2. A dental appliance for detecting and treating teeth clenching, comprising:a first housing containing a battery power source, a vibration device connected to said power source, and an electrical contact mechanism having a movable element which closes a circuit to actuate said vibration device;
a resilient bite portion extending from said first housing and adapted to be emplaced between upper and lower teeth, said bite portion having an interior area which is compressible, as by upper and lower teeth moving toward each other; and
a compressible element disposed in said interior area, said compressible element causing said movable element of said electrical contact to close to actuate said vibration device in response to compression of said bite portion.

US Pat. No. 10,687,973

WALKING BOOTS AND METHODS OF MAKING THE SAME

1. A boot comprising:a rigid outer shell including a main body having: a base portion configured to be positioned adjacent to a portion of a foot of a subject;a leg portion configured to be positioned adjacent to a portion of a leg of the subject; andan ankle support portion that couples the base portion of the main body to the leg portion of the main body, the ankle portion of the main body being configured to be positioned adjacent to two opposing sides of an ankle of the subject, the ankle support portion of the main body having one or more removable elements, a first track including a groove, and an opposing second track including a tongue and being spaced from the first track to define an opening in the ankle support portion, each of the one or more removable elements including a tongue on a first edge and a groove on a second edge,
wherein the tongue of each of the one or more removable elements is configured to slidably engage to the groove of the first track, or to the groove of another one of the one or more removable elements,
wherein a first one of the one or more removable elements, being configured to be positioned adjacent to a first one of the two opposing sides of the ankle, is configured to be removed from the rigid outer shell to aid in preventing contact between an incision area on the first side of the ankle of the subject and the rigid outer shell.

US Pat. No. 10,687,972

MOBILIZING MUSCULOSKELETAL STRUCTURES

1. A support device for protecting a finger or thumb, comprising:a. a support shell comprising a rigid or semi-rigid wall defining a cavity for receiving at least a part of a finger or thumb, the rigid or semi-rigid wall having an interior surface that extends along a length of the finger or thumb, the interior surface facing multiple phalanges of the finger or thumb, the support shell sized and shaped to provide clearance space, when in use, between the finger or thumb and the interior surface, the interior surface configured to provide a low friction interface between the interior surface and the finger or thumb, wherein the clearance space and the low friction interface are configured to mobilize the finger or thumb such that the finger or thumb can move freely within the cavity of the support shell; and,
b. an attachment device for securing the support device to an adjacent musculoskeletal structure of a wearer's hand or arm.

US Pat. No. 10,687,971

PROTECTIVE SLEEVE AND TREATMENT METHOD THEREOF

THE LONNIE BRACE LLC, Fa...

1. A protective sleeve for treating injury to a wearer's elbow and elbow joint of wearer's arm, comprising:a. a central pad, wherein the central pad further comprises an upper portion, a lower portion, a connecting portion, wherein the central pad further comprises an exterior side and an interior side, wherein the central pad further comprises an upper edge, a lower edge, a left edge, and a right edge, wherein the connecting portion is configured to be centrally on the wearer's elbow, wherein the connecting portion connects the upper and lower portions;
b. a protective opening for wearer's medial elbow region formed by the upper portion, the lower portion, and the connecting portion contoured around the wearer's medial elbow region;
c. a cap attached on the exterior side of the central pad;
d. a relatively thin sheet, wherein the relatively thin sheet further comprises an upper edge, a lower edge, a left edge, and a right edge, wherein the left edge of the relatively thin sheet is affixed with the left edge of the central pad, wherein the right edge of the relatively thin sheet is affixed with the right edge of the interior side of the central pad, and wherein a cylindrical space is formed between the relative thin sheet and the central pad;
e. a cylindrical sleeve formed by the relatively thin sheet and the central pad;
f. a first compression strip attached on the interior side within the upper portion of the central pad, wherein the first compression strip creates a first hump;
g. a second compression strip attached on the interior side within the lower portion of the central pad, wherein the second compression strip creates a second hump; and
h. a fastening means for securing the protective sleeve on the wearer's arm.

US Pat. No. 10,687,970

ASSISTANCE DEVICE, ASSISTANCE GARMENT, AND ASSISTANCE METHOD

R.U. TECHNOLOGIES, INC., ...

1. An assistance device that is provided on a garment and reduces a load of an action of a wearer, the assistance device comprising:an assisting part that is removeable from the garment, replaceable and applies force for assisting the action to a body of the wearer by changing longitudinal flexibility of the assisting part without causing a shape change in a cross-sectional direction; and
an assist-control part that controls the longitudinal flexibility of the assisting part.

US Pat. No. 10,687,969

STENT DELIVERY SYSTEM

BOSTON SCIENTIFIC SCIMED,...

1. A stent delivery system comprising:an elongated inner member extending between a distal tip and a proximal end;
a stent support member disposed over the inner member and defining a stent receiving region, the inner member slidable within the stent support member;
at least one stent surrounding the stent receiving region of the stent support member, the stent having a collapsed configuration and an expanded configuration;
an elongated outer sheath slidably disposed over the inner member, the outer sheath extending between a distal end and a proximal end, the outer sheath including a proximal portion and a distal portion located distal of the proximal portion, the distal portion of the outer sheath surrounding the stent to restrain the stent in the collapsed configuration;
a proximal junction detachably coupling the distal portion of the outer sheath to the proximal portion of the outer sheath, the proximal junction being actuatable to selectively uncouple the distal portion of the outer sheath from the proximal portion of the outer sheath;
a distal junction detachably coupling the distal end of the outer sheath to the distal tip of the inner member, the distal junction being actuatable to selectively uncouple the outer sheath from the distal tip;
wherein the distal and proximal junctions are separately actuatable by rotating the inner member relative to the proximal portion of the outer sheath with the proximal portion of the outer sheath held stationary; and
a handle assembly at the proximal end of the inner member, wherein the handle assembly includes a position marker and first and second spaced apart rotational markers indicating a rotational orientation of the inner member;
wherein the proximal junction is uncoupled when the position marker is aligned with the first rotational marker, and wherein the distal junction is uncoupled when the position marker is aligned with the second rotational marker.

US Pat. No. 10,687,968

SEALABLE ENDOVASCULAR IMPLANTS AND METHODS FOR THEIR USE

Edwards Lifesciences Card...

1. A prosthetic implant, comprising:a circumferentially adjustable sealing collar having a central longitudinal axis;
a rotatable sealer gear coupled to and disposed within the sealing collar and configured to adjust the circumference of the sealing collar, wherein the sealer gear is radially offset relative to the central longitudinal axis of the sealing collar, wherein rotating the sealer gear in a first direction relative to the sealing collar circumferentially expands the sealing collar, and wherein rotating the sealer gear in a second direction relative to the sealing collar circumferentially contracts the sealing collar; and
a locking member comprising a bar, wherein the bar of the locking member is selectively movable between a released state and an engaged state relative to the sealer gear.

US Pat. No. 10,687,967

STRETCHABLE STENT AND DELIVERY SYSTEM

COVIDIEN LP, Mansfield, ...

1. A medical device comprising:a tubular implant having first and second ends and extending along a longitudinal axis, the first end of the implant including a tab; and
an implant delivery system comprising a catheter including a retainer configured to secure the first end of the implant to the catheter, wherein the retainer is configured to receive the tab and defines one or more inclined surfaces forming an oblique angle with the longitudinal axis of the implant such that the one or more inclined surfaces faces the tab when the tab is received within the retainer.

US Pat. No. 10,687,966

IMPLANT

Xeltis AG, Zurich (CH) T...

1. A crimped cardiovascular implant for regenerating tissue in vivo, comprising: at least one support structure and a fibrous network consisting of one or more polymer compounds, wherein the fibrous network has at least 60% porosity pores with a diameter ranging from 1 to 300 micrometers, and a linear elastic stiffness ranging from 0.1 to 50 MPa, and wherein the implant is free of cells prior to implantation.

US Pat. No. 10,687,965

MICROPROCESSOR CONTROLLED PROSTHETIC ANKLE SYSTEM FOR FOOTWEAR AND TERRAIN ADAPTATION

Freedom Innovations, LLC,...

1. A prosthetic device, comprising:a pair of prosthetic members, comprising a shank link configured to be coupled to a remnant limb of an amputee, movably coupled together to allow movement of the pair of prosthetic members with respect to one another;
a hydraulic actuator or damper including hydraulic fluid in a hydraulic chamber coupled to one of the pair of prosthetic members, and a single hydraulic piston movably disposed in the hydraulic chamber and coupled to another of the pair of prosthetic members;
a hydraulic flow channel fluidly coupled between opposite sides of the chamber to allow hydraulic fluid to move between the opposite sides of the chamber during movement of the pair of prosthetic members as the hydraulic piston moves therein; and
a voice coil valve coupled to the hydraulic flow channel to vary resistance to flow of hydraulic fluid through the flow channel, wherein the voice coil valve is positioned within the hydraulic chamber;
wherein the hydraulic actuator or damper further comprises a floating piston, and wherein a variable volume chamber is formed between the floating piston and the hydraulic chamber.

US Pat. No. 10,687,964

INTERVERTEBRAL IMPLANT WITH INTEGRATED FIXATION

Howmedica Osteonics Corp....

1. A method of inserting an implant in the intervertebral disc space between two adjacent vertebrae and an anchor engageable with the implant and an adjacent vertebra, the method comprising the steps of:attaching a distal end of an inserter to the implant;
inserting the implant into the disc space by manipulating the inserter; and
cutting an entryway into the adjacent vertebra for the anchor, including sliding a cutter along the inserter and piercing the adjacent vertebra; and
inserting the anchor along a track exposed at a surface of the inserter and into engagement with the implant and the adjacent vertebra, such that while the anchor is disposed within the track, the anchor extends above the surface as it translates along the inserter.

US Pat. No. 10,687,963

EXPANDABLE INTERVERTEBRAL CAGE

EX TECHNOLOGY, LLC, Geri...

1. An expandable intervertebral cage device adapted to be implanted into an intervertebral disc space in a patient's body, comprising:a first base plate having a first outer bearing surface configured to interface with a first vertebra of the intervertebral disc space, the first base plate including a first rod extending through a proximal pivot structure and a proximal end of the first base plate;
a second base plate having a second outer bearing surface configured to interface with a second vertebra of the intervertebral disc space, the second base plate including a second rod extending through the proximal pivot structure and a proximal end of the second base plate;
only a single arm assembly extending between the first base plate and the second base plate on each of a first side of the device and a second side of the device, each arm assembly including only a pair of arms, a first arm of the pair of arms pivotally coupled to the first base plate and not coupled to the second base plate and a second arm of the pair of arms pivotally coupled to the second base plate and not coupled to the first base plate, wherein each of the first arm and the second arm is pivotally coupled to a distal pivot structure distinct from the proximal pivot structure, the distal pivot structure disposed between the first base plate and the second base plate; and
an actuation member extending longitudinally within a space between the first base plate and the second base plate, wherein rotation of the actuation member in a first direction causes the arm assemblies to expand and the rotation of the actuation member in a second direction causes the arm assemblies to contract, and wherein expansion of the arm assemblies causes the first base plate to pivot about the first rod and the second base plate to pivot about the second rod to cause the first base plate and the second base plate to be angled relative to one another.

US Pat. No. 10,687,962

INTERBODY FUSION DEVICES, SYSTEMS AND METHODS

Raed M. Ali, M.D., Inc., ...

1. A spinal fusion system comprising:an endplate system configured for placement within an intervertebral space of a subject, wherein the endplate system comprises an upper endplate and a lower endplate; and
an implant configured to be advanced and positioned between the upper endplate and the lower endplate to secure the implant within the intervertebral space;
wherein, when the implant is advanced between the upper endplate and the lower endplate, the implant is configured to separate the upper endplate relative to the lower endplate along an entire length of the implant and is configured to urge the upper endplate toward an upper vertebral member and the lower endplate toward a lower vertebral member; and
wherein at least one of the upper endplate and the lower endplate comprises at least one engagement member configured to engage a portion of the adjacent vertebral member when the implant has been advanced between the upper and lower endplates.

US Pat. No. 10,687,961

EXPANDABLE INTERBODY AND SYSTEM

1. An expanding interbody comprising:a first articulating member;
a second articulating member rotatably connected to said first articulating member about a hinge;
a clip member that engages each of said first articulating member and said second articulating member, wherein said first articulating member and said second articulating member each comprises an inner face having a ramp portion and a plurality of grooves arranged in an increasingly elongated arrangement as the plurality of grooves of said first articulating member are aligned with the plurality of grooves of said second articulating member, wherein the increasingly elongated arrangement of grooves corresponds to the ramp portion, wherein said clip member comprises protruding tips that sequentially engages the plurality of grooves of said first articulating member and said second articulating member, wherein the protruding tips engage the longest grooves of the increasingly elongated arrangement of grooves prior to extraction of the clip member, and wherein extraction of the clip member from the first and second articulating members causes said first articulating member to rotate angularly and expand open with respect to said second articulating member without expansion of said first articulating member and said second articulating member about the hinge.

US Pat. No. 10,687,960

ASSEMBLED VERTEBRAL BODY

SECOND AFFILIATED HOSPITA...

1. An assembled vertebral body used in a cervical reconstruction operation, comprising: an upper connecting element, an artificial vertebral body element and a lower connecting element, wherein the upper connecting element is disposed at an upper part of the artificial vertebral body element, wherein the lower connecting element is disposed at a lower part of the artificial vertebral body element, wherein the artificial vertebral body element is nestedly connected with the upper connecting element and the lower connecting element, respectively, wherein the upper connecting element comprises a first nesting part disposed at a lower part of the upper connecting element, wherein the lower connecting element comprises a second nesting part disposed at an upper part of the lower connecting element, wherein the artificial vertebral body element comprises a third nesting part disposed at the upper part of the artificial vertebral body element and a fourth nesting part disposed at the lower part of the artificial vertebral body element, wherein the first nesting part is nestedly connected with the third nesting part, wherein the second nesting part is nestedly connected with the fourth nesting part, wherein a nest connection in between the first nesting part and the third nesting part is an anti-axial rotation nested connection, wherein a nest connection in between the second nesting part and the fourth nesting part is an anti-axial rotation nested connection, wherein the first nesting part, the second nesting part, the third nesting part and the fourth nesting part have a non-circular shape, wherein the non-circular shape is an ellipse or a rounded rectangle, wherein the upper connecting element further comprises a coupling plate and a fixing plate, wherein the fixing plate of the upper connecting element is disposed at an upper part of the coupling plate of the upper connecting element, wherein the first nesting part is disposed at a lower part of the coupling plate of the upper connecting element, wherein the lower connecting element further comprises a coupling plate and a fixing plate, wherein the fixing plate of the lower connecting element is disposed at a lower part of the coupling plate of the lower connecting element, wherein the second nesting part is disposed at an upper part of the coupling plate of the lower connecting element, wherein the upper connecting element further comprises a transverse portion, wherein the first nesting part is disposed at a lower part of the transverse portion, wherein the lower connecting element further comprises a transition portion and a mating portion, wherein the mating portion is disposed at a lower portion of the transition portion, wherein the second nesting part is disposed at an upper portion of the transition portion, a front end surface and/or a rear end surface of the transition portion is a polished structure, and the rest of the surfaces of the transition portion are distributed with a spongy microporous structure, the lower surface of the transition portion is a matte surface, the transition portion is a hollow structure, the hollow structure is a bone graft channel, a size of the transition portion is equal to a size of the artificial vertebral body element, a length of the mating portion is equal to a length of 1 to 2 cervical spines, a width of the mating portion is greater than the width of the transition portion.

US Pat. No. 10,687,959

SPINAL FIXATION SYSTEM

PRISM SURGICAL DESIGNS PT...

1. An alignment assembly for aligning and positioning an interbody plate over a disc space in between two adjacent vertebrae, the assembly comprising:a fastener having a long axis and a plate engagement comprising opposed wings converging towards said axis; and
a mate for the fastener configured to receive the fastener thereover at a first end and having a releasable connector with a releasable attachment below the first end;
wherein the fastener is releasably secured to the mate for the fastener as it moves therealong;
wherein the mate for the fastener comprises a body having two sides that are substantially flat;
wherein the body of the mate for the fastener includes an aperture therethrough configured to receive the releasable connector; and
wherein during use the opposed wings contact one or more edges of an aligning aperture of the interbody plate thereby bringing the interbody plate into alignment with the fastener.

US Pat. No. 10,687,958

SIX DEGREE SPINE STABILIZATION DEVICES AND METHODS

Globus Medical, Inc., Au...

1. A method of stabilizing two adjacent bones of a joint, the method comprising: inserting an implant between the bones of the joint, the implant having a first engagementplate comprising a first core engagement surface, wherein a first aperture extends through the first core engagement surface; a second engagement plate comprising a second core engagement surface, wherein a second aperture extends through the second core engagement surface; and a core positioned between the first engagement plate and the second engagement plate, wherein the core comprises a first flanking segment for engaging the first core engagement surface and a second flanking segment for engaging the second core engagement surface, wherein the core comprises an aperture in an upper surface that leads into a hollow interior of the core, wherein the first aperture of the first engagement plate, the second aperture of the second engagement plate, and the hollow interior of the core are aligned along an axis, and wherein the first engagement plate includes a projection that extends from the first core engagement surface and is enclosed by the core to limit movement;
wherein at least one of the first and second engagement plates is able to move relative to the core, thereby enabling a natural kinematic relative movement of the bones,
wherein an inflection region, substantially narrower than the first flanking segment and the second flanking segment, separates the first flanking segment and the second flanking segment, and wherein the inflection region is configured to allow angular displacement of the first flanking segment and the second flanking segment, wherein the inflection region is capable of bending, and
wherein the hollow interior of the core includes a first portion proximate to the first engagement plate, a second portion proximate to the second engagement plate, and a central portion connecting the first and second portions, wherein the central portion is narrower than the first and second portions.

US Pat. No. 10,687,957

SPINAL IMPLANTS FOR ROTATIONALLY ADJUSTING VERTEBRAE

NuVasive, Inc., San Dieg...

1. A spinal implant adapted to be positioned within a disc space between adjacent vertebrae, the implant comprising:a first intradiscal element comprising a first outer surface adapted to be positioned adjacent an endplate of a first one of the adjacent vertebrae and comprising a first medial surface that is opposite the first outer surface, wherein the first intradiscal element comprises a first proximal flange portion that extends generally perpendicularly to a longitudinal axis of the first intradiscal element, and a first borehole extending through the first proximal flange portion, wherein the first proximal flange portion is configured to be positioned against a side aspect of a first vertebra for receipt of a bone screw through the first borehole in a trajectory that is generally parallel with the longitudinal axis of the first intradiscal element, and wherein the first intradiscal element comprises a cap configured to be placed on the first proximal flange portion, the cap comprising holes formed in each side of the cap that align with the first borehole when the cap is placed on the first proximal flange portion, the cap having a thickness in a medial portion selected to provide rotational pressure on a side of the vertebra to which the first proximal flange portion is affixed;
a second intradiscal element comprising a second outer surface adapted to be positioned adjacent an endplate of a second one of the adjacent vertebrae and comprising a second medial surface that is opposite the second outer surface and adapted to generally face the first medial surface upon assembly of the first intradiscal element with the second intradiscal element;
a coupling mechanism that is associated with the first and second medial surfaces and that is adapted to provide relative rotational movement between the first and second intradiscal elements in a plane generally parallel with the first and second medial surfaces and about an axis at a center portion of the first and second medial surfaces; and
a rotational movement resistance mechanism adapted to resist rotational movement from a plurality of incremented relative rotational positions of the first intradiscal element in relation to the second intradiscal element.

US Pat. No. 10,687,956

CORPECTOMY IMPLANTS WITH ROUGHENED BIOACTIVE LATERAL SURFACES

Titan Spine, Inc., Mequo...

1. A corpectomy implant for replacing a functional spinal unit of a patient, wherein the functional spinal unit includes two adjacent vertebrae and an intervening disc, the implant comprising:a body that is generally oval-shaped in transverse cross section, has a height substantially the same as the height of the functional spinal unit to be replaced, the body comprising:
an external top surface configured to contact a superior vertebra of the patient,
an external bottom surface configured to contact an inferior vertebra of the patient, wherein the height of the body is measured from the top surface to the bottom surface,
opposite external lateral sides extending between the external top surface and the external bottom surface,
a substantially hollow center,
an external anterior side extending between the external top surface and the external bottom surface, and including a transverse through aperture in fluid communication with the hollow center, the transverse through aperture having a height that is more than half the height of the body,
an external posterior side opposite to the external anterior side, and extending between the external top surface and the external bottom surface and
at least one vertical through aperture extending from the top surface to the bottom surface and defining a transverse rim on each of the top surface and the bottom surface, wherein a first portion of the transverse rim on the top surface is blunt and radiused along the top of each of the opposing external lateral sides and the top of the external posterior side, and a second portion of the transverse rim on the top surface, defining the external top surface, is not blunt and radiused around the at least one vertical aperture, and wherein a first portion of the transverse rim on the bottom surface is blunt and radiused along the bottom of each of the opposing external lateral sides and the bottom of the external posterior side, and a second portion of the transverse rim on the bottom surface, defining the external bottom surface, is not blunt and radiused around the at least one vertical aperture, and the second portions defining the top and bottom external surfaces, the external posterior side, and at least a portion of each of the external opposite lateral sides each have a roughened bioactive surface, wherein the roughened bioactive surface comprises a pattern of macro-scale, micro-scale, and nano-scale structures capable of facilitating bone growth,
wherein the first portion of each of the transverse rims does not include any roughened surface, and the first portion on the top surface defines a blunt edge at a junction of the roughened bioactive surface of the second portion on the top external surface and the roughened bioactive surfaces of the external posterior side and the opposite external lateral sides, and the first portion on the bottom surface defines a blunt edge at a junction of the roughened bioactive surface of the second portion on the bottom external surface and the roughened bioactive surfaces of the external posterior side and the opposite external lateral sides, and
wherein the body has a sharp edge at a junction of the external anterior side and the external top surface and at a junction of the external anterior side and the external bottom surface.

US Pat. No. 10,687,955

DISTALLY EXPANDING FACET IMPLANT WITH INTEGRATED PLATE AND DELIVERY DEVICE

1. An implant for a cervical intervertebral facet joint, comprising:first and second plates spaced apart in opposition and each having a first end and a second end;
a diverting member positioned between the first and second plates and moveable in engagement with the first and second plates in a direction between the first end and the second end of the first and second plates; and
a driving member coupled with the diverting member, wherein the driving member is operable to cause the diverting member to move in the direction between the first end and the second end of the first and second plates to cause the plates to divert away from each other at and near their respective first ends without diverting away from each other at their respective second ends;
wherein the implant is adapted for insertion in a facet joint, wherein the implant has a first state in which the first ends of the respective first and second plates are not diverted away from each other and a second state in which the first ends of the respective first and second plates are diverted away from each other, wherein the implant is adapted in the first state to be inserted in a facet joint, and wherein the implant is operable in the second state to cause anterior distraction of a facet joint without inducing kyphosis; wherein the respective second ends of the first and second plates are connected by a connector that is adapted to allow the respective second ends of the first and second plates to compress relative to each other and to prevent the respective second ends of the first and second plates from diverting away from each other.

US Pat. No. 10,687,954

INTERSPINOUS IMPLANTS

Zimmer Biomet Spine, Inc....

1. An implant for placement between spinous processes of a spine comprising:a spacer comprising a first end with a first end terminal edge; and at least one first locking member disposed on a sidewall of the first end, a second end with a second end terminal edge, and an elongated slot extending from adjacent the first end to the second end terminal edge;
a first extension comprising a superior lobe, an inferior lobe, a main body, and an aperture disposed in the main body for receiving the spacer, the first extension comprising at least one second locking member disposed on an inner sidewall of the aperture of the main body, that cooperatively engages the at least one first locking member upon rotation of the first extension relative to the spacer in a plane transverse to a longitudinal axis of the spacer to form a first mechanical lock to connect the first extension and the spacer; and
a second extension comprising a superior lobe; an inferior lobe, and a span connecting the superior and inferior lobes, the second extension comprising a post extending into the elongated slot, the second extension and the spacer to form a second mechanical lock to connect the second extension to the spacer; the second mechanical lock including a lock bore and a lock fastener, the lock fastener comprising a nut, a head, and a shaft, wherein the head is rotationally received in the lock bore and the shaft forms the post that extends into the elongated slot, and wherein rotation of the lock fastener within the lock bore causes the nut to clamp the lock fastener to a sidewall of the spacer.

US Pat. No. 10,687,953

APPARATUSES AND METHODS FOR ANTERIOR CERVICAL TRANSARTICULAR FIXATION

The Board of Regents of t...

1. An anterior cervical transarticular fixation implant for fixation of the C1 and C2 vertebrae of a patient, the implant comprising:a cervical plate including:
a central body,
lateral wings that extend laterally outward from the central body, each lateral wing including a fastener opening configured to receive a fastener configured to thread into vertebrae, and
locking mechanisms configured to selectively lock the fasteners in place;
wherein the central body and the lateral wings are curved in a manner in which the cervical plate is configured to fit the contours of the anterior side of the C2 vertebra;
wherein the fastener openings extend posteriorly and upwardly through the cervical plate such that, when the cervical plate is applied to the C2 vertebra, fasteners passed through the fastener openings are directed through C2 vertebra and into the C1 vertebra.

US Pat. No. 10,687,952

FLEXIBLE, CANNULATED IMPLANTS FOR THE HAND AND FOOT AND METHODS OF IMPLANTING FLEXIBLE IMPLANTS

1. A flexible interphalangeal bone implant comprising:a proximal stem having a proximal end, a distal end, and a proximal conduit having a length extending from the proximal end to the distal end of said proximal stem, wherein said proximal conduit is open at both the proximal and distal ends of said proximal stem;
a distal stem having a proximal end, a distal end, and a distal conduit having a length extending from the proximal end to the distal end of said distal stem, wherein said distal conduit is open at both the proximal and distal ends of said distal stem;
a flexible hinge interconnecting the distal end of said proximal stem with the proximal end of said distal stem for allowing said proximal and distal stems to flex relative to one another, wherein said flexible hinge comprises a top side defined by a first sloping sidewall at the distal end of said proximal stem, a second sloping sidewall at the proximal end of said distal stem that opposes said first sloping sidewall, and a flat top surface that extends between and interconnects lower ends of said first and second sloping sidewalls;
a discrete proximal stem protective tube disposed within said proximal conduit of said proximal stem, wherein said proximal stem protective tube has a length that matches the length of said proximal conduit; and
a discrete distal stem protective tube disposed within said distal conduit of said distal stem, wherein said distal stem protective tube has a length that matches the length of said distal conduit;
wherein the proximal and distal stem protective tubes are sized and configured to receive an elongated pin extending in series through said proximal stem protective tube disposed within said proximal stem, said first sloping sidewall, said second sloping sidewall, and said distal stem protective tube disposed within said distal stem;
wherein said proximal stem, said distal stem, and said flexible hinge comprise a unitary structure monolithically made of a polymer material, and wherein said proximal stem protective tube and said distal stem protective tube are made of metal.

US Pat. No. 10,687,951

GLENOID COMPONENT FOR USE IN SHOULDER ARTHROPLASTY

DePuy Synthes Products, I...

1. A glenoid assembly, comprising:a base component having a humeral-facing side and a scapula-facing side, the base component defining a bearing surface defined on the humeral-facing side;
a first anchor peg extending from the scapula-facing side of the base component, the first anchor peg including a first shaft with a first passageway extending through the first shaft; and
a second anchor peg extending from the scapula-facing side of the base component, the second anchor peg including a second shaft with a second passageway extending through the second shaft,
wherein the first anchor peg and the second anchor peg are positioned in non-parallel orientation with respect to each other.

US Pat. No. 10,687,950

PERIPROSTHETIC SHOULDER FRACTURE REPAIR

Genesis Medical Devices L...

1. A prosthesis comprising:a joint interface surface, configured to articulate in situ against a second joint interface surface of a companion joint structure;
one or more contingent features integrally disposed on or within the prosthesis;
a removable contingent component interfaced with at least one of the contingent features, and
wherein the removable contingent component is arranged to be removable so as to both:
provide access for insertion of a fracture stabilization component within a medullary canal of a shoulder bone in which the prosthesis is configured to reside; and
expose the one or more contingent features for use in securing the fracture stabilization component with the prosthesis.

US Pat. No. 10,687,949

SHOULDER PROSTHESIS AND COMPONENTS THEREOF

ZIMMER GMBH, Winterthur ...

1. A shoulder prosthesis comprising:a glenoidal component including a glenoidal articulation surface;
a humeral component including a humeral articulation surface; and
a mobile glenohumeral bearing component including an exterior glenoidal bearing surface and an exterior humeral bearing surface arranged on opposite sides of the glenohumeral bearing component, wherein the glenoidal and humeral bearing surfaces are both concave, and wherein the glenohumeral bearing component is disposed, in an implanted state, between the glenoidal component and the humeral component such that the glenoidal bearing surface contacts the glenoidal articulation surface and the humeral bearing surface contacts the humeral articulation surface.

US Pat. No. 10,687,948

MORPHOLOGICALLY CURVED SAGITTAL WALL OF A TIBIAL IMPLANT

Mako Surgical Corp., For...

1. A preoperatively shaped prosthetic implant for preserving bone comprising:a bone contacting surface;
an articular surface opposite the bone contacting surface;
a sagittal wall extending between the bone contacting and articular surfaces and anterior and posterior points;
anterior and posterior rounded corners, the anterior rounded corner extending anteriorly to the anterior point and the posterior rounded corner extending posteriorly to the posterior point,
wherein the sagittal wall traverses a non-linear path corresponding to a curvature of a virtual bone model based on the dimensions of at least one bone, the non-linear path having at least first and second curves from the anterior point to the posterior point of the prosthetic implant such that the entirety of the sagittal wall does not lie in a single sagittal plane.

US Pat. No. 10,687,947

AUGMENTS AND METHODS FOR IMPLANTING HIP PROSTHESES

Biomet Manufacturing, LLC...

1. A method of anchoring an orthopedic hip prosthesis including a shell or a cup to an acetabulum of a living being, the method comprising:placing an augment at a bone surface of the acetabulum, wherein the augment is an anchor having a body including a first surface opposite a second surface and an opening extending through the body from the first surface to the second surface, the method further including;
applying a layer of fixation material over the bone surface in an amount sufficient to cover the augment; and
implanting the prosthesis over the layer of fixation material to secure the prosthesis to the layer of fixation material,
the method further including:
identifying a target bone location;
inserting a fastener through the opening;
attaching the fastener to the target bone location to secure the anchor to the acetabulum, wherein after attaching the fastener to the target bone location, applying the layer of fixation material includes covering the anchor and the bone surface with the layer of fixation material, wherein the layer of fixation material forms a surrogate bone surface for the target bone location and bone surrounding the target bone location to support the prosthesis; and
placing three or more substantially spherical spacers at the bone surface after applying the layer of fixation material to the bone surface, and wherein placing the three or more substantially spherical spacers includes inserting the three or more spacers into the layer of fixation material in a triangular arrangement, the method further including pressing the prosthesis into the layer of fixation material until the prosthesis bottoms out on the three or more substantially spherical spacers, and
wherein the layer of fixation material is a bone cement and wherein a presence of the three or more substantially spherical spacers in the bone cement controls a target thickness of the bone cement that supports the prosthesis.

US Pat. No. 10,687,946

DEVICE FOR STABILISING JOINTS

Betterguards Technology G...

1. A device for stabilizing joints, comprising:a receptacle of the device for stabilizing joints, wherein the receptacle is filled with a filling medium,
a first body for interaction with the filling medium, wherein the first body is arranged displaceably in the receptacle,
a force transmitter configured to directly transmit an external force onto the first body,
a second body for interaction with the filling medium, wherein the second body is arranged displaceably in the receptacle,
wherein the second body is coupled elastically to the first body via a coupling element disposed between the first body and the second body,
wherein at least one of the second body and the first body have at least one outlet opening through which the filling medium can flow,
wherein the first body forms a valve body of a valve and the second body forms a valve seat of the valve, and the first body and the second body are configured to open to allow or close to prevent a flow of the filling medium between one side of the receptacle and another side of the receptacle through the at least one outlet based on an open or closed position of the valve, wherein the second body divides the receptacle into the one side of the receptacle and another side of the receptacle, and
wherein the valve is configured such that the position of the valve is open when the first body is out of contact with the second body and is closed when the first body moves towards and contacts the second body.

US Pat. No. 10,687,945

CHANNEL IMPLANT

Poriferous, LLC, Newnan,...

1. A channel implant used for surgical reconstruction and/or repair, comprising two porous sheets of material; and a channel formed between the two porous sheets of material, the channel configured for fixation plate insertion, the porosity of the two porous sheets of material changing to non-porous along at least some areas of the channel during thermal processing of the sheets with heat and pressure, forming an at least partially non-porous channel; wherein the resulting channel implant has a substantially uniform cross-sectional thickness along the channel implant that is 1.75 mm or less.

US Pat. No. 10,687,944

PENIS IMPLANT, PARTICULARLY FOR FEMALE-TO-MALE TRANSSEXUAL

ZEPHYR SURGICAL IMPLANTS,...

1. A penile implant comprising an elongate erectile body supported by a symphyseal anchoring mount, comprising a mounting plate presenting a bearing face, the erectile body extending from the face opposite the bearing face, the implant being characterized in that the mounting plate extends in a plane and in that the erectile body extends in a direction that forms an angle of inclination with a plane of the bearing face, which angle lies in a range of from 5° to 30°, the erectile body comprising at its end that is opposite the end provided with the symphyseal anchoring mount, a bulbous portion forming a glans.

US Pat. No. 10,687,943

ANNULOPLASTY SYSTEM

1. An annuloplasty device configured to be implanted in a heart valve, said heart valve comprising valve tissue including an annulus and a pair of leaflets and having an atrial side and a ventricular side, said annuloplasty device comprising:a first support member and a second support member
wherein the first and the second support members overlap and crisscross each other to form a scissor linkage and
wherein the first and second support members are configured to pinch the leaflets.

US Pat. No. 10,687,942

CORONARY SINUS MITRAL VALVE ANNULOPLASTY PROCEDURE AND CORONARY ARTERY AND MYOCARDIAL PROTECTION DEVICE

THE UNITED STATES OF AMER...

1. A device for protecting a coronary artery from compression during catheter-based mitral annuloplasty, the device comprising:a surgically sterile implant having a proximal end, a distal end, and an arched portion positioned between the proximal and distal ends, the implant being configured to fit within a coronary sinus of a heart, wherein the arched portion is configured to rest in the coronary sinus and straddle the left circumflex artery (LCX), the implant defining a passageway along at least a portion of the implant between the proximal end and the distal end of the implant; and
an elongate tether extending through at least a portion of the passageway of the implant and configured to extend entirely around the mitral valve and be placed under tension, wherein the arched portion of the implant has sufficient rigidity and dimensions to inhibit application of pressure to the LCX when the implant is positioned at said location with the elongate tether extending entirely around the mitral valve under tension, causing the arch of the implant to orient away from the coronary artery, thereby protecting the coronary artery from compression.

US Pat. No. 10,687,941

MEDICAL DEVICE, KIT AND METHOD FOR CONSTRICTING TISSUE OR A BODILY ORIFICE, FOR EXAMPLE, A MITRAL VALVE

KARDIUM INC., Burnaby (C...

1. An implant kit comprising:a helical tissue anchor comprising a plurality of coils;
a percutaneous delivery system operable to at least partially embed the helical tissue anchor into a tissue insertion location in tissue within a body during an implant procedure, the percutaneous delivery system comprising a member comprising a lumen; and
a guide rail configured to provide the helical tissue anchor to the tissue insertion location, a portion of the guide rail located within at least some of the plurality of coils of the helical tissue anchor at least in a state in which the guide rail is at least partially located within the lumen of the member,
wherein the guide rail comprises a bend configured to facilitate the helical tissue anchor spiraling off of the guide rail into tissue at a particular location spaced from an end of the guide rail via the helical tissue anchor rotating with respect to the guide rail.

US Pat. No. 10,687,940

ARRANGEMENT FOR MONITORING A POSITIONING OF A PROSTHETIC CARDIAC VALVE AND CORRESPONDING METHOD

SIEMENS HEALTHCARE GMBH, ...

1. A prosthetic cardiac valve implantation arrangement, comprising: a prosthesis catheter, including a prosthetic cardiac valve to be inserted; an ICE catheter for introduction into an area surrounding a cardiac valve to be treated, and to detect at least one of a relative position and relative direction of orientation of the cardiac valve with respect to the ICE catheter with aid of at least one ultrasound image of the cardiac valve recorded by the ICE catheter; a navigation system to determine an absolute position and absolute direction of orientation of the ICE catheter; and a control facility to control insertion of the prosthetic cardiac valve into an annulus of the cardiac valve based upon ultrasound images recorded by the ICE catheter and at least one of the absolute position and absolute direction of orientation determined by the navigation system, wherein the ICE catheter is configured to create at least one of 2D ultrasound images in several planes and 3D ultrasound images of the cardiac valve to determine at least one of an absolute reference position and an absolute reference direction of orientation of the cardiac valve, a display to simultaneously depict information with respect to at least one of an absolute position and an absolute orientation of the prosthetic cardiac valve and the at least one of 2D and 3D ultrasound images for monitoring the insertion of the prosthetic cardiac valve into the annulus of the cardiac valve, and wherein the control facility is further configured to check correct insertion of the prosthetic cardiac valve based upon a comparison of at least one of a current position and a current direction of orientation of the prosthetic cardiac valve with a respective at least one of the absolute reference position determined and the absolute reference direction of orientation of the cardiac valve determined.

US Pat. No. 10,687,939

PROSTHETIC VALVE FOR REPLACING A MITRAL VALVE

Edwards Lifesciences Corp...

1. A prosthetic valve for implanting at a native mitral or tricuspid valve region of the heart, the native valve region having a native valve annulus and native leaflets, the prosthetic valve comprising:a radially compressible and expandable frame comprising a double-body structure including an annular inner frame portion and an annular outer frame portion overlapping the inner frame portion, the inner and outer frame portions being connected to each other with sutures, and the outer frame portion being more flexible than the inner frame portion;
an outer fabric skirt extending around an outer surface of the outer frame;
a plurality of prosthetic leaflets supported within the inner frame portion for regulating the flow of blood in one direction through the frame; and
a plurality of ventricular anchors located outside of the outer skirt and extending from the inner frame portion, the ventricular anchors having a length to extend behind and engage native valve leaflets in a ventricle of the heart downstream of the native valve annulus.

US Pat. No. 10,687,938

HEART VALVE DOCKING SYSTEM

Edwards Lifesciences Corp...

1. A docking device for docking a prosthetic valve at a native heart valve, the docking device comprising:a flexible body comprising an elongate tubular structure, a first lumen extending at least partially through the flexible body, and a second lumen extending at least partially through the flexible body;
a first coil more rigid than the flexible body, comprising a first plurality of circular turns, the first coil configured to fit within the first lumen, and the first plurality of circular turns comprising a first diameter in a relaxed state;
a second coil more rigid than the flexible body, comprising a second plurality of circular turns, the second coil configured to fit within the second lumen, and the second plurality of circular turns comprising a second diameter in a relaxed state that is less than the first diameter;
wherein the docking device has a first configuration with a third diameter when the first coil is positioned within the first lumen;
wherein the docking device has a second configuration with a fourth diameter when the second coil is positioned within the second lumen, and wherein the fourth diameter is less than the first diameter and the third diameter.

US Pat. No. 10,687,937

SYSTEMS AND METHODS FOR PERFORMING OSSICULAR CHAIN RECONSTRUCTIONS

1. A prosthetic device for performing ossicular reconstructions, comprising:a body extending along a longitudinal axis, the body including a first fastener segment, a second fastener segment, and a central segment between the first fastening segment and the second fastening segment; and
the central segment is adjustable to either lengthen or shorten the body in a direction that is coaxial with the longitudinal axis,
wherein the central segment includes a plurality of arched plates that are arranged together to form a spherical shape.

US Pat. No. 10,687,936

HYBRID ACCOMMODATING INTRAOCULAR LENS ASSEMBLAGES

RAYNER INTRAOCULAR LENSES...

1. A hybrid accommodating intraocular lens assemblage for implantation in a post-capsulorhexis human eye having a visual axis, an annular ciliary body, and a vacated capsular bag having an annular anterior capsule flange and an intact posterior capsule,the ciliary body having a relaxed ciliary body state for distance vision and a contracted ciliary body state for near vision, the ciliary body peripherally tensioning the capsular bag on its relaxation from its contracted ciliary body state to its relaxed ciliary body state, the hybrid accommodating intraocular lens assemblage comprising:
(a) a discrete base member having a base member centerline and including a flat circular base member centerpiece and a peripheral base member surround,
said flat circular base member centerpiece having a base member centerpiece refractive index, an anterior base member centerpiece surface and a posterior base member centerpiece surface,
said base member having an elevated circumferential retainer bounding a circumferential groove with said anterior base member centerpiece surface; and
(b) a discrete lens unit having
i) a lens optic having a lens optic refractive index, a lens optic axis for co-axial alignment with the visual axis, an anterior lens optic surface with a primary optical power for distance vision and a posterior lens optic surface having a central circle with an additional optical power to said primary optical power for near vision, and
ii) at least two spaced apart resiliently flexible lens haptics radially extending from said lens optic for insertion in said circumferential groove for anchoring said discrete lens unit on said discrete base member for urging said lens optic away from said discrete base member for separating said posterior lens optic surface from said anterior base member centerpiece surface, said at least two spaced apart resiliently flexible lens haptics each having a free end remote from said lens optic, said elevated circumferential retainer being configured to overlie said free ends for anchoring said discrete lens optic on said discrete base member, and enabling rotation of said discrete lens unit to a predetermined position relative to said discrete base member stationary in the post-capsulorhexis human eye, andwherein said base member centerpiece and said lens optic have the same refractive index, and whereupon, pursuant to an initial implantation of said discrete base member in the vacated capsular bag and a subsequent implantation of said discrete lens unit in the vacated capsular bag between said base member and the anterior capsule flange,in the relaxed ciliary body state, the vacated capsular bag urges said lens optic and said base member towards each other such that said posterior lens optic surface is intimately immerged in said anterior base member centerpiece surface for creating a single refractive index optical continuum nullifying said posterior lens optic surface's optical power whereby the hybrid accommodating intraocular lens assemblage has optical power for distance vision only, and
in the contracted ciliary body state, the vacated capsular bag enables said at least two spaced apart resiliently flexible lens haptics to space apart said lens optic and said base member such that said posterior lens optic surface is spaced apart from said anterior base member centerpiece surface for adding said central circle's additional optical power to said anterior lens optic surface's primary optical power whereby the hybrid accommodating intraocular lens assemblage has a combined optical power for near vision.

US Pat. No. 10,687,935

METHODS OF MOLDING INTRAOCULAR LENSES

AcuFocus, Inc., Irvine, ...

1. A method of manufacturing an intraocular lens, the method comprising:filling an annular mask-forming feature in a lens mold with an opaque mask material, the annular mask-forming feature comprising a trough provided in a portion of the lens mold;
adding optically transmissive optic material over the opaque mask material; and
fully curing the opaque mask material and the optically transmissive optic material to form a mask and an optic, the mask being sufficient to prevent transmission of at least 90% of incident visible light.

US Pat. No. 10,687,933

MUCOSAL CAPTURE FIXATION OF MEDICAL DEVICE

BFKW, LLC, Ada, MI (US)

1. An implantable medical device adapted to be fixed in a hollow organ or cavity lined with mucosa, said medical device comprising:an expandable wall defining a lumen with proximal and distal ends thereof and configured to the size and shape of a portion of the organ or cavity;
said wall configured to press against the mucosa of the hollow organ or cavity when expanded in the portion of the hollow organ or cavity;
said wall having at least two adjacent openings separated by a bridge, said at least two adjacent openings being between said proximal and distal ends, each of said openings having a size that is large enough to cause the mucosa to bulge into that opening in a manner that maintains perfusion of the mucosa when said wall is expanded in the portion of the hollow organ or cavity; and
said adjacent openings configured to be close enough together that the mucosa that bulges into said openings comes together over said bridge to fix said medical device in said hollow organ or cavity.

US Pat. No. 10,687,932

THROMBUS FILTER AND UTILIZATION METHOD THEREOF

Venus Medtech (Hangzhou) ...

1. A thrombus filter comprising:a sheath;
a thrombus intercepting net having a distal end, a proximal end, and an intercepting port positioned at the distal end, wherein the intercepting port has a center;
a first pushing piece connected to the thrombus intercepting net;
an overfill prevention umbrella having a proximal end and a distal end with a distal opening that is adjacent to the intercepting port, wherein the overfill prevention umbrella is a meshed structure;
a second pushing piece which is located in the sheath and is connected to the overfill prevention umbrella;
wherein the thrombus intercepting net and the overfill prevention umbrella are retained inside the sheath when the thrombus filter is delivered to a treatment site;
wherein the overfill prevention umbrella comprises an umbrella stand and an umbrella surface with the umbrella stand having a first end connected to the second pushing piece and a second end connected to the umbrella surface, and wherein the umbrella surface has an open end defining the distal opening, wherein the overfill prevention umbrella is configured such that at body temperature, the umbrella surface converges towards the center of the intercepting port;
wherein the thrombus filter assumes a first position when the thrombus intercepting net is released from the sheath, where the distal opening of the overfill prevention umbrella is pushed open by the intercepting port of the thrombus intercepting net, wherein in the first position the distal end of the overfill prevention umbrella aligned with the distal end of the thrombus intercepting net and the proximal end of the overfill prevention umbrella aligned with the proximal end of the thrombus intercepting net;
wherein the thrombus filter assumes a second position when the thrombus intercepting net is retrieved into the sheath, and in the second position the umbrella surface of the overfill prevention umbrella converges towards the center of the intercepting port of the thrombus intercepting net and the open end of the umbrella surface is constricted to prevent the thrombus from escaping, wherein the thrombus intercepting net is movable with respect to the overfill prevention umbrella such that the thrombus intercepting is configured in use to only be retracted relative to the overfill prevention umbrella.

US Pat. No. 10,687,931

BLOOD CLOT FILTER WITH LOCAL THROMBOLYTIC DRUG DELIVERY

HeartWare, Inc., Miami L...

1. A thrombus capture and lysis device, comprising:a filter sized to be implanted within a blood vessel, the filter including a first upstream portion and a second downstream portion, both portions being configured to be in contact with a wall of the blood vessel at an oblique angle when the filter is implanted within the blood vessel, the filter further including a plurality of hollow elements defining a mesh sized to span an area of the blood vessel and an anchoring element, the anchoring element being entirely defined by the plurality of hollow elements, each of the plurality of hollow elements defining a plurality of pores, the plurality of pores being sized to allow passage of a thrombolytic drug out through the plurality of pores and to prevent a thrombus forming component from entering the plurality of pores, the filter further defining a planar first surface configured to face an upstream direction of the blood vessel and an opposite second surface, the plurality of pores being entirely disposed on the planar first surface.

US Pat. No. 10,687,930

VASCULAR FILTER DEVICE

Novate Medical Limited, ...

1. A vascular filter device comprising:a support for engaging a wall of a blood vessel, wherein the support comprises a proximal support hoop and a distal support hoop;
exactly one filter supported on the support and comprising one or more Y-shaped filter elements each having at least two proximal segments connected to the proximal support hoop and at least one distal segment at least temporarily restrained at an apex when the one or more Y-shaped filter elements are across at least part of a cross-section of a vessel when in a filtering closed position,
wherein the exactly one filter is disposed between the proximal support hoop and the distal support hoop,
wherein at least one filter element extends radially outwardly with respect to a device longitudinal axis when unconstrained, and
wherein when unconstrained, the at least one distal segment extends radially outwardly at an angle to the at least two proximal segments, and the at least two proximal segments each have a length of less than 10 mm.

US Pat. No. 10,687,929

SURGICAL INSTRUMENT FOR DEPLOYING A PROSTHESIS

1. A surgical instrument for deploying a prosthesis intended to repair a hernial defect comprising:at least one sheet made of a flexible resilient material, said sheet continuously overlapping itself one or more times so as to define a plurality of levels forming a spiral, wherein a central hole passes through said plurality of levels and said spiral is configured to adopt an idle configuration in which the spiral is flat and the plurality of levels are in contact with each other.

US Pat. No. 10,687,928

APPARATUS FOR VAGINAL PENETRATION OF ANIMALS COMPRISING A VIEWING SYSTEM, IN PARTICULAR FOR LOCATING THE CERVIX OF THE UTERUS

IMV TECHNOLOGIES, Saint ...

1. A work assembly comprising:an apparatus for aiding in vaginal penetration comprising: a handling shaft, a guide tube extending the shaft to form a compact assembly, and a video viewing tube, comprising lighting at a front end of the video viewing tube; the video viewing tube being received in the guide tube; the shaft comprising a video system rear cell having an image transmitter for transmitting to a remote screen images coming from the video viewing tube; and
a work tool received in said apparatus, said work tool being an insemination gun configured for penetrating a vagina to reach a cervix of a uterus of an animal, said work tool passing through the shaft, in relation to which the work tool is slidable, the work tool comprises a front tip, and is movable between a position in which the front tip is received in the guide tube and a position in which the front tip projects forward from the guide tube.

US Pat. No. 10,687,927

METHOD AND DEVICE TO AUTOMATICALLY DETECT CALVING

LELY PATENT N.V., Maassl...

1. A method to automatically predict a calving moment of a pregnant cow, comprising: recording, by a three-dimensional camera system, at least one three- dimensional image of the cow; and processing, by processing circuitry, the at least one image of the cow, wherein processing of the image comprises: determining at least one a first parameter and a second parameter indicative of the calving moment, and predicting on the basis of the first parameter and the second parameter a calving moment of the cow, wherein the first parameter is an orientation parameter representative of an orientation of the cow, wherein a second parameter is a body contraction parameter representative of body contraction of the cow, and wherein the predicting of the calving moment of the cow is performed based on a weighed combination of the first and second parameter, wherein the weighted combination applies a weight that is more than 0 and less than 1.

US Pat. No. 10,687,926

PHOTOTHERAPY DEVICES AND METHODS

KLOX TECHNOLOGIES INC., ...

1. A method for phototherapy, comprising:attaching to a light source a probe member, the probe member having a flexible fiber optic tip member with a polymer or glass core and a photoactivating agent for transmitting light, wherein the photoactivating agent is: i) within the polymer or glass core; or ii) on a surface of the polymer or glass core, and an elastic tubular connector sleeve, for mechanically coupling the flexible tip member to a light source;
introducing the flexible tip member in a the treatment region; and
activating the photoactivating agent by applying light through the flexible fiber optic tip member.

US Pat. No. 10,687,925

BRUSH HEAD AND ELECTRIC TOOTHBRUSH

BRAUN GMBH, Kronberg (DE...

1. A replaceable brush head for an electric toothbrush, comprising:a housing attachable to and detachable from a handle of the electric toothbrush;
a carrier having a mounting side having a shape selected from a circular, oval, or elliptical shape, wherein the carrier is mounted at the housing for driven oscillatory rotational motion around a rotation axis that extends through a center point on the mounting side of the carrier;
a plurality of tufts comprising filaments mounted on the mounting side of the carrier;
wherein each of the tufts has a tufting area of at least about 2.4 mm2, and the filaments in each of the tufts have a cross-sectional area perpendicular to their length extension direction that corresponds to a circular cross-sectional area having a diameter of between 0.102 mm and 0.127 mm;
wherein the brush head comprises only the tufts of the defined tufting area and diameter.