US Pat. No. 10,479,813

UTILITY OF NEMATODE SMALL MOLECULES

California Institute of T...

1. A method of reducing eosinophils (eos) or lymphocytes (lym), or both, in a subject, comprising:administering a therapeutically effective dosage of a composition to the subject, thereby reducing eos or lym, or both, in the subject,
wherein the composition comprises a pharmaceutically acceptable carrier and a compound of Formula (I)
whereinR1 is, independently for each occurrence, hydrogen or alkyl;R1? is, independently for each occurrence, hydrogen or alkyl;X is C(R1)2;X1 is cis- or trans-C(R1)?C(R1);n1, n2, and n3 are each independently an integer of 0 to 30, inclusive;n4 is an integer of 1 to 30, inclusive;the sum of n1, each n2, and each n3 is 1 to 30, inclusive;R3 is hydrogen or alkyl;R4 is hydrogen or alkyl;R5? is hydrogen, alkyl, halogen, —OR6, or —N(R6)2;R5 is —OR6 or —N(R6)2; andR6 is independently alkyl, alkenyl, aryl, or heteroaryl, wherein the alkyl, alkenyl, aryl, or heteroaryl is optionally substituted,or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,479,805

BETA-LACTAMASE INHIBITOR

WUHAN VISION PHARMACEUTIC...

1. A compound having a formula of:

US Pat. No. 10,479,804

PREPARATION OF AMMONIUM OR PHOSPHONIUM BORATE SALTS

Gotion Inc., Fremont, CA...

1. A process for preparing an ammonium or phosphonium borate salt KA containing a cation K and an anion A, comprising the steps:(a) providing a melt of a borate salt K1A; and
(b) adding a solution of an ammonium or phosphonium salt KA1 in a solvent or solvent mixture (i),
wherein
K is an organic ammonium or phosphonium cation;
A is a borate anion of formula (Ia) or (Ib)

wherein Hal is halogen, and
is a bidentate radical derived from a 1,2-, 1,3- or 1,4-diol, from a 1,2-, 1,3- or 1,4-dicarboxylic acid or from a 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups of the respective diol, hydroxycarboxylic acid or dicarboxylic acid in 1,2-, 1,3- or 1,4-position;A1 is an organic or inorganic anion; and
K1 is an ammonium cation different from K.

US Pat. No. 10,479,803

BICYCLIC HETEROARYLAMINOALKYL PHENYL DERIVATIVES AS PI3K INHIBITORS

Incyte Corporation, Wilm...

1. A method of inhibiting an activity of a PI3K? kinase, comprising contacting the kinase with a compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein:Ar is:

R1 is methyl;
R2 is C1-6 alkoxy, C1-6 haloalkoxy, or phenyl; wherein said phenyl is optionally substituted by 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkoxy;
R3 is Cy or C(?O)NRcRd;
provided that either (i) R2 is phenyl, wherein said phenyl is optionally substituted by 1, 2, or 3 substituents independently selected from halo, OH, CN, C1-4 alkyl, C1-4 alkoxy, and C1-4 haloalkoxy; or (ii) R3 is Cy;
R4 is halo, C1-4 alkyl, or C1-4 haloalkyl;
R5 is halo, CN, C1-4 alkyl, or C1-4 haloalkyl;
R6 is H;
each Cy is independently selected from 4-6 membered heterocycloalkyl or 5-6 membered heteroaryl, each of which is optionally substituted with 1 or 2 independently selected R3b groups;
each Rc and Rd is independently selected from H and C1-6 alkyl and each R3b is independently selected from halo, CN, C1-6 alkyl, C1-6 haloalkyl, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, and di(Cl6 alkyl)carbamyl.

US Pat. No. 10,479,802

PROBES FOR IMAGING HUNTINGTIN PROTEIN

CHDI Foundation, Inc., N...

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof,
wherein
X is NR4, O, or S;
Y is CR4 or N;
Z1, Z2, Z3, and Z4 are independently chosen from CH and N, provided that at least two of Z1, Z2, Z3, and Z4 are CH;
R1 is heteroaryl, heterocycloalkenyl, or heterocycloalkyl, each of which is optionally substituted with one or two groups independently chosen from cyano, halo, lower alkyl optionally substituted with amino, alkylamino, or di(alkyl)amino, lower alkoxy optionally substituted with lower alkoxy, optionally substituted amino, haloalkyl, di(alkyl)aminocarbonyl, alkylaminocarbonyl, and aminocarbonyl, or
R1 is phenyl optionally substituted with one or two groups independently chosen from cyano, heteroaryl, halo, phenoxy, benzyloxy, heteroaryl, lower alkyl optionally substituted with amino, (alkyl)amino, or di(alkyl)amino, lower alkoxy, optionally substituted amino, di(alkyl)aminocarbonyl, alkylaminocarbonyl, and aminocarbonyl;
L1 is —O—;
L2 is —(CR7R8)m—;
L3 is —CH?CH— or is absent;
R2 is phenyl, pyridin-2-yl, pyridin-3-yl, pyrazin-2-yl, pyrimidin-5-yl, 1H-imidazol-4-yl, 1H-imidazol-2-yl, or 1H-pyrazol-4-yl, each of which is optionally substituted with one or two groups independently chosen from halo; haloalkyl; hydroxyl; lower alkoxy; lower alkoxy substituted with lower alkoxy, amino, (alkyl)amino, (dialkyl)amino, heterocycloalkyl, heteroaryl, or halo; lower alkyl; and lower alkyl substituted with hydroxyl, lower alkoxy, amino, (alkyl)amino, or (dialkyl)amino;
R4 is chosen from hydrogen, halo, cyano, and lower alkyl;
R5 is chosen from lower alkyl, lower alkoxy, and halo;
R7 is chosen from hydrogen, hydroxyl, trifluoromethyl, and lower alkyl;
R8 is chosen from hydrogen and lower alkyl;
n is 0 or 1; and
m is 0, 1, or 2;
wherein the compound of Formula (I), or a pharmaceutically acceptable salt thereof, is labeled with one or more positron-emitting radionuclides.

US Pat. No. 10,479,801

TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

1. A compound having the formula:or a pharmaceutically acceptable salt thereof,wherein:----- represents an optional double bond;
ring A, inclusive of the carbon atom and nitrogen atom to which ring A is fused, is a 5- to 8-membered monocyclic or bicyclic heterocycloalkyl group, which can be optionally and independently substituted on ring A carbon atom with a group selected from C1-C6 alkyl, —O—(C1-C6 alkyl) and C3-C7 cycloalkyl, and which can be optionally and independently substituted on a ring nitrogen atom with a group selected from C1-C6 alkyl, —C(O)—(C1-C6 alkyl) and —S(O)2—(C1-C6 alkyl);
X is selected from 5 or 6-membered monocyclic heteroaryl and —N(R4)C(O)—;
R1 is a phenyl group which is optionally substituted with from 1 to 3 groups, each independently selected from C1-C6 alkyl, halo, —O—(C1-C6 alkyl), C1-C6 haloalkyl, —O—(C1-C6 haloalkyl), —CN, —NO2, —N(R4)2, —C(O)OR6, —C(O)N(R4)2 and —NHC(O)R6;
R2 is selected from H, C1-C6 alkyl, C3-C7 cycloalkyl, halo, C1-C6 haloalkyl, —OR5, —N(R4)2, —C(O)R5, —C(O)N(R4)2 and —NHC(O)R5, wherein said C1-C6 alkyl group is optionally substituted with one or more groups, each independently selected from halo, —OH, —O(C1-C6 alkyl) and —N(R4)2;
R3 is selected from H, C1-C6 alkyl and —O—(C1-C6 alkyl), —N(R4)2;
each occurrence of R4 is independently selected from H and C1-C6 alkyl;
each occurrence of R5 is independently selected from H, C1-C6 alkyl and C3-C7 cycloalkyl;
each occurrence of R6 is independently selected from H and C1-C6 alkyl; and
R7 is selected from H and C1-C6 alkyl.

US Pat. No. 10,479,800

COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION

UNIVERSITY OF VIRGINIA PA...

1. A method of increasing oxygen consumption, reducing cellular reactive oxygen species, depolarizing a mitochondrial inner membrane, and increasing oxygen consumption rate without donating electrons to the electron transport chain using a mitochondrial uncoupler, said method comprising contacting a cell or mitochondria with a composition comprising at least one compound having a structure of formula I or formula II:
or active analogs or derivatives thereof,
wherein R1-R10 are all independently optional, and when present are each independently selected from the group consisting of H, halogen, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, thiol, sulfone, sulfoxide, oxo, oxy, nitro, carbonyl, carboxy, amino acid sidechain, and amino acid, wherein each group can be optionally substituted; or

or active analogs and derivatives thereof,
wherein R1-R2 are independently optional, and are each independently selected from the group consisting of H, halogen, hydroxy, acyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclo, aryl, heteroaryl, alkoxy, amino, amide, thiol, sulfone, sulfoxide, oxo, oxy, nitro, carbonyl, carboxy, amino acid sidechain, and amino acid, wherein each group can be optionally substituted.

US Pat. No. 10,479,796

SPIRO-OXAZOLONES

Hoffman-La Roche Inc., L...

1. A compound of formula I,
wherein
X1 is C—R1 or N;
X2 is C—R1 or N;
X3 is C—R1 or N;
X4 is C—R1, N or NO;
whereby only one of X1, X2, X3 and X4 is N;
R1 each separately is selected from the group consisting of hydrogen, halogen, hydroxy, C1-6-alkyl and C1-6-alkoxy;
R2 is selected from the group consisting of H and C1-6-alkyl;
R3 is selected from the group consisting of H and C1-6-alkyl;
or R2 and R3 together are ?O;
Y1 is C—R4 or N;
Y2 is C—R4 or N;
Y3 is C—R4 or N;
Y4 is C—R4 or N;
whereby only one of Y1, Y2, Y3 and Y4 is N;
R4 each separately is selected from the group consisting of hydrogen, halogen, halogen-C1-6-alkyl, hydroxy, C1-6-alkyl, C1-6-alkoxy and Si(C1-6-alkyl)3;
m is 1 or 2; and
n is 1;
or pharmaceutically acceptable salts thereof.

US Pat. No. 10,479,795

SUBSTITUTED IMIDAZO[2,1-F][1,2,4]TRIAZINES, SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES AND SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PI3K-GAMMA INHIBITORS

Incyte Corporation, Wilm...

1. A method for treating a disease or disorder in a patient, wherein the disease or disorder is selected from the group consisting of a cardiovascular disease, a neurodegenerative disease, an autoimmune disease, an autoimmune disorder, and cancer, comprising administering to the patient in need thereof a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt thereof; wherein:
X1 is N or CR1;
X2 is N or CR2;
X3 is N or CR3;
X4 is N or CR4;
X5 is N or CR5;
X6 is N or CR6;
X3, X4, X5 and X6 are not simultaneously N;
R7 is H or C1-6 alkyl optionally substituted with 1, 2 or 3 groups independently selected from halo, OH, oxo, CN, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, C6-10 aryl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, NH2, C1-6 alkyl-NH—O and (C1-6 alkyl)2N—;
R1, R2, R3, R4, R5, R6 and R8 are each independently selected from H, D, halo, oxo, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 haloalkoxy, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-14 membered heteroaryl)-C1-4 alkyl-, (4-14 membered heterocycloalkyl)-C1-4 alkyl-, CN, NO2, ORa1, SRa1, NHORa1, C(O)Ra1, C(O)NRa1Ra1, C(O)ORa1, OC(O)Ra1, OC(O)NRa1Ra1, NHRa1, NRa1Ra1, NRa1 C(O)Ra1, NRa1C(O)ORa1, NRa1C(O)NRa1Ra1, C(?NRa1)Ra1, C(?NRa1)NRa1Ra1, NRa1C(?NRa1)NRa1Ra1, NRa1C(?NOH)NRa1Ra1, NRa1C(?NCN)NRa1Ra1, NRa1S(O)Ra1, NRa1S(O)2Ra1, NRa1S(O)2NRa1Ra1, S(O)Ra1, S(O)NRa1Ra1, S(O)2Ra1, SF5, —P(O)Ra1Ra1, —P(O)(ORa1)(ORa1,B(ORa1)2 and S(O)2NRa1Ra1, wherein the C1-6alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-14 membered heteroaryl)-C1-4 alkyl-, and (4-14 membered heterocycloalkyl)-C1-4 alkyl- of R1, R2, R3, R4, R5, R6 and R8 are each optionally substituted with 1, 2, 3, 4 or 5 independently selected Rb substituents;
R9 is H, D, CN, C(O), NH2, —OH, —COOH, —NH(C1-6 alkyl), —NH(C1-6 alkyl)2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 haloalkoxy, wherein the C1-6 alkyl is optionally substituted with 1, 2 or 3 independently selected Rq substituents;
R10 is selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-14 membered heteroaryl)-C1-4 alkyl-, (4-14 membered heterocycloalkyl)-C1-4 alkyl-, ORa2, SRa2, NHORa2, C(O)Ra2, C(O)NRa2Ra2, C(O)ORa2, NHRa2, NRa2Ra2, NRa2C(O)Ra2, NRa2C(O)ORa2, NRa2C(O)NRa2Ra2, C(?NRa2)Ra2, C(?NRa2)NRa2Ra2, NRa2C(?NRa2)NRa2Ra2, NRa2S(O)Ra2, NRa2S(O)2Ra2, NRa2S(O)2NRa2Ra2, S(O)Ra2, S(O)NRa2Ra2, S(O)2Ra2, and S(O)2NRa2Ra2, wherein the C1-6 alkyl , C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-14 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-14 membered heteroaryl)-C1-4 alkyl-, and (4-14 membered heterocycloalkyl)-C1-4 alkyl- of R10 are each optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected Rb substituents;
L is

 wherein each R11 is independently H, C1-6 alkyl, or C3-10 cycloalkyl optionally substituted with 1 or 2 Rq substituents and wherein the single wavy line indicates the point of attachment to R10and the double wavy line indicates the point of attachment to the 6-membered ring A;
or when L is

 R10 and R11 optionally taken together with the nitrogen atom to which they are attached, form 4 to 14 membered heterocycloalkyl or a 4 to 14 membered heterocycloalkyl-C1-4 alkyl- having 0 to 4 additional heteroatoms as a ring member, each of which is independently selected from N, O and S, wherein the 4 to 14-membered heterocycloalkyl formed by R10, R11 and N is optionally substituted with 1, 2, 3, 4, 5, 6, 7 or 8 independently selected Rb substituents;
Ra1 and Ra2 are each independently selected from H, D, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-14 membered heterocycloalkyl)-C1-4 alkyl-, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl- and (4-14 membered heterocycloalkyl)-C1-4 alkyl- of Ra1 and Ra2 are each optionally substituted with 1, 2, 3, 4, or 5 independently selected Rd substituents;
each Rb substituent is independently selected from D, halo, oxo, C1-4 alkyl, C1-6 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, (4-14 membered heterocycloalkyl)-C1-4 alkyl-, CN, OH, NH2, NO2, NHORc, ORc, SRc, C(O)Rc, C(O)NRcRc, C(O)ORc, OC(O)Rc, OC(O)NRcRc, C(?NRc)NRcRc, NRcC(?NRc)NRcRc, NRcC(?NOH)NRc, NRcC(?NCN)NRcRc, SF5, —P(O)RcRc, —P(O)(ORc)(ORc), NHRc, NRcRc, NRcC(O)Rc, NRcC(O)ORc, NRcC(O)NRcRc, NRcS(O)Rc, NRcS(O)2Rc, NRcS(O)2NRcRc, S(O)Rc, S(O)NRcRc, S(O)2Rc or S(O)2NRcRc; wherein the C1-4 alkyl, C1-6 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-14 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-and (4-14 membered heterocycloalkyl)-C1-4 alkyl- of Rb are each further optionally substituted with 1, 2, or 3 independently selected Rd substituents;
each Rc is independently selected from H, D, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl- and (4-10 membered heterocycloalkyl)-C1-4 alkyl- of Rc are each optionally substituted with 1, 2, 3, 4, or 5 independently selected Rf substituents;
each Rf is independently selected from C1-4 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, halo, CN, NHORg, ORg, SRg, C(O)Rg, C(O)NRgRg, C(O)ORg, OC(O)Rg, OC(O)NRgRg, NHRg, NRgRg, NRgC(O)Rg, NRgC(O)NRgRg, NRgC(O)ORg, C(?NRg)NRgRg, NRgC(?NRg)NRgRg, NRgC(?NOH)NRgRg, NRgC(?NCN)NRgRg, SF5, —P(O)RgRg, —P(O)(ORg)(ORg), S(O)Rg, S(O)NRgRg, S(O)2Rg, NRgS(O)2Rg, NRgS(O)2NRgRg, and S(O)2NRgRg; wherein the C1-4 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- of Rf are each optionally substituted with 1, 2, 3, 4, or 5 independently selected Rn substituents;
each Rn is independently selected from C1-4 alkyl, C1-4 haloalkyl, halo, CN, Ro, NHORo, ORo, SRo, C(O)Ro, C(O)NRoRo, C(O)ORo, OC(O)Ro, OC(O)NRoRo, NHRo, NRoRo, NRoC(O)Ro, NRoC(O)NRoRo, NRoC(O)ORo, C(?NRo)NRoRo,NRoC(?NRo)NRoRo, NRoC(?NOH)NRoRo, NroC(?NCN)NRoRo, SF5, —P(O)RoRo, —P(O)(ORo)(ORo), S(O)Ro, S(O)NRoRo, S(O)2Ro, NRoS(O)2Ro, NRoS(O)2NRoRo, and S(O)2NRoRo;
each Rd is independently selected from D, oxo, C1-6 alkyl, C1-6 haloalkyl, halo, C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, CN, NH2, NHORe, ORe, SRe, C(O)Re, C(O)NReRe, C(O)ORe, OC(O)Re, OC(O)NReRe, NHRe, NReRe, NReC(O)Re, NReC(O)NReRe, NReC(O)ORe, C(?NRe)NReRe, NReC(?NRe)NReRe, NReC(?NOH)NReRe, NReC(?NCN)NReRe, SF5, —P(O)ReRe, —P(O)(ORe)(ORe), S(O)Re, S(O)NReRe, S(O)2Re, NReS(O)2Re, NReS(O)2NReRe, and S(O)2NReRe, wheren the C1-6 alkyl, C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl -C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- of Rd are each optionally substituted with 1, 2, or 3 independently selected Rf substituents;
each Rd is independently selected from H, D, CN, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl- and (4-10 membered heterocycloalkyl)-C1-4 alkyl- of Re are each optionally substituted with 1, 2 or 3 independently selected Rg substituents;
each Rg is independently selected from H, D, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl- and (4-10 membered heterocycloalkyl)-C1-4 alkyl- of Rg are each optionally substituted with 1, 2 or 3 independently selected Rp substituents;
each Rp is independently selected from C1-4 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, halo, CN, NHORr, ORr, SRr, C(O)Rr, C(O)NRrRr, C(O)ORr, OC(O)Rr, OC(O)NRrRr, NHRr, NRrRr, NRrC(O)Rr, NRrC(O)NRrRr, NRrC(O)ORr, C(?NRr)NRrRr, NRrC(?NRr)NRrRr, NRrC(?NOH)NRrRr, NRrC(?NCN)NRrRr, SF5, —P(O)RrRr, —P(O)(ORr)(ORr), S(O)Rr, S(O)NRrRr, S(O)2Rr, NRrS(O)2Rr, NRrS(O)2NRrRr, and S(O)2NRrRr;
or any two Ra1 substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7-, 8-, 9- or 10-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 independently selected Rh substituents;
each Rh is independently selected from C1-6 alkyl, C3-10 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C3-10 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, (4-7 membered heterocycloalkyl)-C1-4 alkyl-, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, halo, CN, ORi, SRi, NHORi, C(O)Ri, C(O)NRiRi, C(O)ORi, OC(O)Ri, OC(O)NRiRi, NHRi, NRiRi, NRiC(O)Ri, NRiC(O)NRiRi, NRiC(O)ORi, C(?NRi)NRiRi, NRiC(?NRi)NRiRi, NRiC(?NOH)NRiRi, NRiC(?NCN)NRiRi, SF5, —P(O)Ri Ri, —P(O)(ORi)(ORi), S(O)Ri, S(O)NRiRi, S(O)2Ri, NRiS(O)2Ri, NRiS(O)2NRiRi, and S(O)2NRiRi, wherein the C1-6 alkyl, C3-10 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C3-10 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, (4-7 membered heterocycloalkyl)-C1-4 alkyl- of Rh are each further optionally substituted by 1, 2, or 3 independently selected Rj substituents;
each Rj is independently selected from C3-6 cycloalkyl, C6-10 aryl, 5 or 6-membered heteroaryl, C2-4 alkenyl, C2-4 alkynyl, halo, C1-4 alkyl, C1-4 haloalkyl, CN, NHORk, ORk, SRk, C(O)Rk, C(O)NRkRk, C(O)ORk, OC(O)Rk, OC(O)NRkRk, NHRk, NRkRk, NRkC(O)Rk, NRkC(O)NRkRk, NRkC(O)ORk, C(?NRk)NRkRk, NRkC(?NRk)NRkRk, NRkC(?NOH)NRkRk, NRkC(?NCN)NRkRk, SF5, —P(O)RkRk, —P(O)(ORk)(ORk), S(O)Rk, S(O)NRkRk, S(O)2Rk, NRkS(O)2Rk, NRkS(O)2NRkRk, and S(O)2NRkRk; or two Rj groups attached to the same carbon atom of the 4to 10-membered heterocycloalkyl taken together with the carbon atom to which they attach form a C3-6 cycloalkyl or 4to 6-membered heterocycloalkyl having 1-2 heteroatoms as ring members selected from O, N or S;
or any two Ra2 substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7-, 8-, 9- or 10-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 Rh substituents;
or any two Rc substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Re substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Rg substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Ri substituents together with the nitrogen atom to which they are attached form a 4-, 5- , 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Rk substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Ro substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
or any two Rr substituents together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 independently selected Rh substituents;
each Ri, Rk, Ro or Rr is independently selected from H, D, C1-4 alkyl, C3-6 cycloalkyl, C6-10 aryl, 5 or 6-membered heteroaryl, C1-4 haloalkyl, C2-4 alkenyl, and C2-4 alkynyl, wherein the C1-4 alkyl, C3-6 cycloalkyl, C6-10 aryl, 5 or 6-membered heteroaryl, C2-4 alkenyl, and C2-4 alkynyl of Ri, Rk, Ro or Rr are each optionally substituted with 1, 2 or 3 independently selected Rq substituents;
each Rq is independently selected from D, OH, CN, —COOH, NH2, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-4 alkylthio, phenyl, 5-6 membered heteroaryl, C3-6 cycloalkyl, 4-6 membered heterocycloalkyl, —CONHR12, —NHC(O)R12, —OC(O)R12, —C(O)OR12, —C(O)R12, —SO2R12, —NHSO2R12, —SO2NHR12 and NR2R2, wherein the C1-6 alkyl, phenyl, 4-6 membered heterocycloalkyl and 5-6 membered heteroaryl of Rq are each optionally substituted with OH, CN, —COOH, NH2, C1-6 alkoxy, C3-6 cycloalkyl or 4-6 membered heterocycloalkyl; and
each R12 is independently C1-6 alkyl;
provided that:
when R7 is C1-6 alkyl, R10-L- is other than cyclopropylsulfamoyl and methanesulfonamido;
when R7 is cyclopropylmethyl, R10-L- is other than methanesulfonamido;
when R7 is 2-(4-morpholino)ethyl, R10-L- is other than methanesulfonyl; and
the compound is other than 3-(8-aminoimidazo[1,2-a]pyridin-3-yl)-2-(1H-tetrazol-5-yl)benzenesulfonamide.

US Pat. No. 10,479,794

CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE

Boehringer Ingelheim Inte...

1. A method of inhibiting PDE2 in a mammal comprising administering to the mammal an effective amount of a compound of formula (I)whereinA is selected from the group Aa consisting of

wherein above mentioned groups are substituted with one R5 and one R6;
R1 is selected from the group R1a consisting of
halogen, C1-3-alkyl- and C3-6-cycloalkyl- wherein the above mentioned C1-3-alkyl-, and C3-6-cycloalkyl- groups may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of halogen, NC— and HO—;
R2 is selected from the group R2a consisting of
aryl and heteroaryl,
wherein the above mentioned aryl and heteroaryl-groups may optionally be substituted with 1 to 5 substituents R4;
R3 is selected from the group R3a consisting of
H— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-groups may optionally be substituted with 1 to 7 substituents independently from each other selected from the group consisting of halogen;
R4 is independently from each other selected from the group R4a consisting of
halogen, NC—, HO—, C1-4-alkyl- and C1-3-alkyl-O—
wherein the above mentioned C1-4-alkyl- and C1-3-alkyl-O-groups may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—;
R5 is selected from the group R5a consisting of
H—, halogen, NC—, HO— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-group may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—
or R5 and R6 together form an group O?;
R6 is selected from the group R6a consisting of
H—, halogen, NC—, HO— and C1-3-alkyl-,
wherein the above mentioned C1-3-alkyl-group may optionally be substituted with 1 to 5 substituents independently selected from the group consisting of HO— and F—
or R5 and R6 together form a group O?;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,479,793

IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

Bristol-Myers Squibb Comp...

1. A compound of the formulawhereinR1 is —NHR2;
R2 is C1-C6 alkyl or C3-C8 cycloalkyl;
R3 is H, C1-C6 alkyl, hydroxy C1-C6 alkyl or mono or bicyclic C3-C8 cycloalkyl;
R4 is H, C1-C6 alkyl, mono or bicyclic C3-C6 cycloalkyl, phenyl, or pyridyl, any of said groups other than H substituted with 0-4 R7;
R5 is H or C1-C4 alkyl;
R7 is H, halo, CN, CF3, C1-C4 alkyl, C1-C4 alkoxy, —CONH C1-C6 alkyl, —CONH halo C1-C6 alkyl, —CONH halo C1-C6 alkoxy, heteroaryl, or aryl, said aryl and heteroaryl groups substituted with 0-2 R8;
R8 is H, halo, CF3, C1-C4 alkyl or C1-C4 alkoxy;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.

US Pat. No. 10,479,791

HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS

CHANGZHOU JIEKAI PHARMATE...

1. A compound of formula I:
and/or a pharmaceutically acceptable salt thereof;
wherein:
X is C—R, wherein R is hydrogen, halo, alkyl, haloalkyl, —CN, or alkoxy;
Y is a monocyclic or 6,5-fused bicyclic aryl or heteroaryl optionally substituted with at least one group selected from halo, alkyl, alkenyl, alkoxy, alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, —OH, —CN, —COORa, —SO2NRaRb, —CONRaRb, and —NRaRb, wherein each of the group alkyl, alkenyl, alkoxy, alkynyl, aryl, cycloalkyl, heteroaryl and heterocyclyl is optionally substituted with at least one group selected from alkoxy, alkyl, halo, OH, —CN, —COORa, —SO2NRaRb, —CONRaRb, and —NRaRb;
R2 is hydrogen, aryl, —CONRaRb, alkyl, alkoxy, —COORa, cycloalkyl, heteroaryl, or heterocyclyl;
R3 is hydrogen, alkyl, aryl, cycloalkyl, alkenyl, alkynyl, alkoxy, heteroaryl, or heterocyclyl;
wherein each of the alkyl, alkoxy, aryl, cycloalkyl, alkenyl, alkynyl, heteroaryl, and heterocyclyl for R2 and/or R3 is optionally substituted with at least one group selected from —OH, alkoxy, halo, and alkyl;
Ra and Rb are independently H, alkyl, aryl, cycloalkyl, heterocyclyl, or heteroaryl, wherein each of the alkyl, aryl, cycloalkyl, heterocyclyl, and heteroaryl is optionally substituted with at least one group selected from halo, alkyl, haloalkyl, alkoxy, —C(O)alkyl, —SO2-alkyl, —OH, cycloalkyl, and heterocyclyl optionally substituted with at least one group selected from alkyl, —C(O)-alkyl, and —SO2-alkyl; or
Ra and Rb, together with the atoms to which they are attached, form a heterocyclic ring optionally substituted with at least one group selected from halo, alkyl, haloalkyl, alkoxy, and —OH; and
n is 1.

US Pat. No. 10,479,790

COMT INHIBITING METHODS AND COMPOSITIONS

LIEBER INSTITUTE FOR BRAI...

1. A method of treating a neurological or psychiatric disorder for which inhibiting COMT provides a therapeutic effect, or treating symptoms associated with the neurological or psychiatric disorder, comprising administering to a subject in need thereof an effective amount of a COMT-inhibiting compound in accordance with formula I, or a pharmaceutically acceptable salt thereof,
wherein:
X is selected from hydrogen, halogen, C?N, CF3, and C1-C4 alkyl;
Z is selected from SO2R1 and SO2NR2R3;
R1 is selected from C1-C10 alkyl, C3-C10 cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl and heteroarylalkyl, any of which may be substituted with one or more groups selected from halogen, C?N, CF3, OH, C1-C4 alkyl or C2-C4 alkenyl, alkoxy, nitro, amino, C1-C4 alkylamino, oxo, C3-C10 cycloalkyl, acyl, aryl, aralkyl, heterocyclyl, heteroaryl, CON(R)2, SO2R, and SO2N(R)2, where each R is independently C1-C4 alkyl or (R)2 forms a carbocyclic ring;
R2 and R3 are independently selected from hydrogen and any of the groups as defined for R1, with the proviso that at least one of R2 and R3 is different from hydrogen; or R2 and R3 may together form a 3-10 membered monocyclic, bicyclic or spirocyclic nitrogen-containing ring system that contains 0-3 additional heteroatoms selected from oxygen (O), nitrogen (N), and sulfur (S), and which may be further substituted with one or more groups selected from halogen, C?N, CF3, OH, C1-C4 alkyl or C2-C4 alkenyl, C3-C6 cycloalkyl, alkoxy, nitro, amino, C1-C4 alkoxycarbonyl, acyl, C1-C4 alkylamino, oxo, SO2CH3, aryl, aralkyl, heterocyclyl, heteroaryl and heteroarylalkyl;
with the proviso that when X is hydrogen and Z is SO2R1, R1 is not C4 alkyl, C8 alkyl, tetrahydropyran or propylcyclopropane;
or when X is H and Z is SO2NR2R3, R2 and R3 do not together form a 1-piperidinyl ring substituted with a ?-methyl group;
or when X is C1 and Z is SO2R1, R1 is not C3 alkyl, C4 alkyl or C5-C6 cycloalkyl;
or when X is C1 and Z is SO2NR2R3, R2 and R3 do not together form an unsubstituted, 1-pyrrolidinyl ring.

US Pat. No. 10,479,788

COMPOUNDS THAT INHIBIT MPS1 KINASE

Cancer Research Technolog...

1. A method of treating a proliferative disorder in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of a compound according to formula Ic, or a pharmaceutically acceptable salt or solvate thereof:
wherein:
R1 is selected from chloro, (1-6C)alkyl, (1-8C)heteroalkyl, aryl, aryl(1-2C)alkyl, heteroaryl, heteroaryl(1-2C)alkyl, heterocyclyl, heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl(1-2C)alkyl, NR7R8, OR9, C(O)R9, C(O)OR9, OC(O)R9, N(R10)OR9, N(R10)C(O)OR9, C(O)N(R10)R9, N(R10)C(O)R9, S(O)pR9 (where p is 0, 1 or 2), SO2N(R10)R9, N(R10)SO2R9, N(R10)SOR9 and SON(R10)R9;
and wherein R1 is optionally substituted by one or more substituent groups selected from fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, (1-4C)alkoxy, S(O)qCH3 (where q is 0, 1 or 2), methylamino or dimethylamino, aryl, aryl(1-2C)alkyl, heteroaryl, heteroaryl(1-2C)alkyl, heterocyclyl, heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, and (3-8C)cycloalkyl(1-2C)alkyl,
and wherein any (1-4C)alkyl, (1-4C)alkoxy, aryl, heteroaryl, heterocyclyl, or (3-8C)cycloalkyl moiety present within a substituent group on R1 is optionally further substituted by fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, NRaRb, ORa, C(O)Ra, C(O)ORa, OC(O)Ra, N(Rb)ORa, C(O)N(Rb)Ra, N(Rb)C(O)Ra, S(O)pRa (where p is 0, 1 or 2), SO2N(Rb)Ra, or N(Rb)SO2Ra, wherein Ra and Rb are each independently selected from H and (1-4C)alkyl;
R3 is hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl, halo, CF3, CN or (1-4C)alkoxy;
R4 is hydrogen, (1-3C)alkyl, (1-3C)alkoxy, fluoro, chloro or CF3;
Ar has the formula:

wherein:
(i) all of A1, A2 and A3 are CH;
(ii) one of A1, A2 and A3 is N and the others are CH; or
(iii) two of A1, A2 and A3 are N and the other is CH;
R5 is selected from hydrogen, cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)fluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR15R16 or S(O)2NR15R16, and wherein R15 and R16 are each independently selected from H and (1-3C)alkyl,
and wherein any alkyl or alkoxy moities present within a R5 substituent group are optionally further substituted by hydroxy or methoxy;
R6 is selected from halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, ureido, (1-6C)alkyl, (2-6C)alkenyl, and (2-6C)alkynyl,
or R6 is a group of the formula:
-L1-L2-R17
wherein
L1 is absent or a linker group of the formula —[CR18R19]n— in which n is an integer selected from 1, 2, 3 and 4, and R18 and R19 are each independently selected from hydrogen and (1-2C)alkyl;
L2 is absent or is selected from O, S, SO, SO2, N(R20), C(O), C(O)O, OC(O), CH(OR20), C(O)N(R20), N(R20)C(O), N(R20)C(O)N(R21), S(O)2N(R20), and N(R21)SO2, wherein R20 and R21 are each independently selected from hydrogen and (1-2C)alkyl; and
R17 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;
and wherein R17 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, NR22R23, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, heterocyclyl, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryl-(1-2C)alkyl, CONR22R23, and SO2NR22R23; wherein R22 and R23 are each independently selected from hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl and (3-6C)cycloalkyl(1-2C)alkyl;
and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl, (1-2C)alkoxy, SO2(1-2C)alkyl or NReRf (where Re and Rf are each independently selected from hydrogen, (1-3C)alkyl, (3-6C)cycloalkyl, and (3-6C)cycloalkyl(1-2C)alkyl);
or R17 is a group having the formula:
-L3-L4-R24
wherein L3 is absent or a linker group of the formula —[CR25R26]n— in which n is an integer selected from 1, 2, 3 and 4, and R25 and R26 are each independently selected from hydrogen and (1-2C)alkyl;
L4 is absent or is selected from O, S, SO, SO2, N(R27), C(O), C(O)O, OC(O), CH(OR27), C(O)N(R27), N(R27)C(O), N(R27)C(O)N(R28), S(O)2N(R27), and N(R28)SO2, wherein R27 and R28 are each independently selected from hydrogen and (1-2C)alkyl; and
R24 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;
R8 and R9 are each independently selected from hydrogen, (1-6C)alkyl, (1-6C)alkoxy, (3-9C)cycloalkyl, (3-9C)cycloalkyl-(1-2C)alkyl, aryl, aryl-(1-2C)alkyl, heterocyclyl, heterocyclyl-(1-2C)alkyl, heteroaryl, and heteroaryl-(1-2C)alkyl; and wherein R8 and R9 are optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3 (1-2C)alkyl and (1-2C)alkoxy;
R7 and R10 are independently selected from hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, and (3-6C)cycloalkyl-(1-2C)alkyl; and wherein R7 and R10 are optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl and (1-2C)alkoxy;
subject to the proviso that
R6 is not methoxy when R1 is S(O)2R9 and R9 is heterocyclyl; and
wherein the proliferative disorder is a cancer selected from lung, colon, breast, ovarian, prostate, liver, pancreas, brain or skin cancer.

US Pat. No. 10,479,787

PROCESS FOR PREPARATION OF TETRABENAZINE AND DEUTETRABENAZINE

Lupin Limited, Maharasht...

1. A process for preparation of deutetrabenazine (II) comprising:
i) obtaining dihydroxy benzoquinoline compound (III)

by reacting dihydroxy isoquinoline compound (IV) or a salt thereof

with (2-acetyl-4-methyl-pentyl)-trimethyl-ammonium iodide (V) or 3-methylene-5-methyl-2-hexanone (VI), and

ii) treating dihydroxy benzoquinoline compound (III) with a source of deuteriated methyl, wherein the source of deuteriated methyl is deuteriated methanol.

US Pat. No. 10,479,786

PROTEIN KINASE INHIBITORS

Princeton Drug Discovery,...

1. A compound of formula I:and/or a salt, an enantiomer or an enantiomeric mixture thereof;wherein
W1, W2, and W3 are independently hydrogen or deuterium;
Y is C—H or nitrogen;
R1 is
-Q-A
wherein
Q is a single bond directly attaching A to a ring carbon atom, or a methylene or ethylene group connecting A to a ring carbon atom; and
A is

wherein
Y1 is C—H or nitrogen and Y2 is carbon and wherein A is a five or six membered ring;
Z1 and Z2 are independently hydrogen, —(CH2)n—OR5, or [—NR7R6], where n is an integer number from 0 to 4, and R5 R6 are independently hydrogen, lower alkyl, or lower alkenyl;
T1 and T2 are independently an integer number from 0 to 4 with the provisos that when T1 or T2 is 0, —(CH2)T1 or —(CH2)T2 is a single bond;
R2 and R3 are independently hydrogen; halogen; alkoxyl; lower alkyl or lower alkenyl, wherein the lower alkyl or lower alkenyl is optionally substituted with one or more substituents selected from —OH and alkoxyl, wherein alkoxyl is methoxy, ethoxy, propyloxy, or tert-butoxy; or optionally substituted heterocyclo, wherein optionally substituted includes [—NR7R6], wherein R6 and R7 are independently hydrogen, lower alkyl, or lower alkenyl;and wherein the positions of R1, R2 and R3 are exchangeable.

US Pat. No. 10,479,785

N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS

AUCENTRA THERAPEUTICS PTY...

1. A compound of formula I shown below:
wherein:
z represents an optional bond such that the bond between N and the adjacent carbon atom can be a single or double bond;
R1, R4, R6 and R7 are each independently selected from the group consisting of H, alkyl, alkyl- R10, aryl, aryl-R10, aralkyl, aralkyl-R11, halogen, NO2, CN, CF3, OH, O-alkyl, COR10, COOR10, O-aryl, O—R10, NH2, NH-alkyl, NH-aryl, N-(alkyl)2, N-(aryl)2, N-(alkyl)(aryl), NH—R10, N—(R10)(R11), N-(alkyl)(R10), N-(aryl)(R10), SH-alkyl, SH-aryl, S-(alkyl)2, S-(aryl)2, S-(alkyl)(aryl), SH—R10,S—(R10)(R11), S-(alkyl)(R10), S-(aryl)(R10), COOH, CONH2, CONH-alkyl, CONH-aryl, CON-(alkyl)(R10), CON(aryl)(R10), CONH—R10, CON—(R10)(R11), SO3H, SO2-alkyl, SO2-alkyl-R10, SO2-aryl, SO2-aryl-R10, SO2NH2, SO2NH—R10, SO2N—(R10)(R11), CF3, CO-alkyl, CO-alkyl-R10, CO-aryl, CO-aryl-R10 and R12,
wherein said alkyl, aryl and aralkyl groups may be optionally substituted with one or more groups selected from halogen, CN, OH, O-methyl, NH2, COOH, CONH2 and CF3, and wherein when bond z is absent, R1 is taken together with R8 and is ?O or ?S;
R2 is alkyl;
R3 is H, C1-6 alkyl, CN or halogen;
R5 is selected from alkyl, alkyl-R10, aryl, aryl-R10, aralkyl, aralkyl-R11, halogen, NO2, CN, CF3, OH, O-alkyl, COR10, COOR10, O-aryl, O—R10, NH2, NH-alkyl, NH-aryl, N-(alkyl)2, N-(aryl)2, N-(alkyl)(aryl), NH—R10, N—(R10)(R11), N-(alkyl)(R10), N-(aryl)(R10), SH-alkyl, SH-aryl, S-(alkyl)2, S-(aryl)2, S-(alkyl)(aryl), SH—R10, S—(R10)(R11), S-(alkyl)(R10), S-(aryl)(R10), COOH, CONH2, CONH-alkyl, CONH-aryl, CON-(alkyl)(R10), CON(aryl)(R10), CONH—R10, CON—(R10)(R11), SO3H, SO2-alkyl, SO2-alkyl-R10, SO2-aryl, SO2-aryl-R10, SO2NH2, SO2NH—R10, SO2N—(R10)(R11), CF3, CO-alkyl, CO-alkyl-R10, CO-aryl, CO-aryl-R10 and R12, wherein said alkyl, aryl and aralkyl groups may be optionally substituted with one or more groups selected from halogen, CN, OH, O-methyl, NH2, COOH, CONH2 and CF3;
R8 is together with R1?O or ?S when bond z is absent, or is not present when bond z is present; R9 is H, alkyl, aryl or heterocyclic group when bond z is absent, or is not present when bond z is present; and
R10, R11 and R12 are independently selected from water solubilising groups;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,479,783

COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY

Rigel Pharmaceuticals, In...

3. A pharmaceutical composition comprising the compound according to claim 1.

US Pat. No. 10,479,780

AMINOPYRAZOLE DERIVATIVES

Chugai Seiyaku Kabushiki ...

1. A compound represented by formula (I) below:
wherein Ar1 is C6-10 arylene or 5- to 10-membered heteroarylene optionally substituted with a group selected from Group R;
Ar2 is C6-10 aryl or 5- to 10-membered heteroaryl optionally substituted with a group selected from Group R;
R1 and R2 are each independently a halogen atom, C1-6 alkyl, C3-6 cycloalkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, cyano, nitro, NR5R6, OR7, SR8, SOR8, SO2R8, CONR9R10, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, 5- to 10-membered heteroaryl optionally substituted with a group selected from Group Q, or C6-10 aryl optionally substituted with a group selected from Group P,
where the 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q is optionally further linked to 4- to 6-membered heterocyclyl optionally substituted with a group selected from 4- to 6-membered heterocyclyl and C6-10 aryl-C1-6 alkyl, or to C3-6 cycloalkyl through a spiro linkage;
R5 and R6 are each independently a hydrogen atom, C1-6 alkyl optionally substituted with 4- to 6-membered heterocyclyl, amino-C1-6 alkyl, C1-6 alkylcarbonyl optionally substituted with a halogen atom, —SO2R30, —C(O)OR31, —C(O)NR32R33, 4- to 6-membered heterocyclylcarbonyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q; or alternatively, R5 and R6, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
R7 is a hydrogen atom; C1-6 alkyl which optionally has, as a substituent, a group selected from amino, a halogen atom, and hydroxy; 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q; or C1-6 alkyl having, as a substituent, 4- to 10-membered heterocyclyl optionally substituted with a group selected from Group Q;
R8 is C1-6 alkyl, halo-C1-6 alkyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
R9 and R10 are each independently a hydrogen atom or C1-6 alkyl; or alternatively, R9 and R10, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
R30 is optionally substituted C1-6 alkyl, C3-6 cycloalkyl which optionally has dihydroxy-C1-6 alkyl as a substituent, C6-10 aryl optionally substituted with a group selected from Group P, 5- to 10-membered heterocyclyl optionally substituted with a group selected from Group Q, 5- to 10-membered heteroaryl optionally substituted with a group selected from Group Q, or —NR34R35,
where the substituent in the optionally substituted C1-6 alkyl is selected from the group consisting of a halogen atom, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, —C(O)NR36R37, and C6-10 aryl;
R31 represents C1-6 alkyl which optionally has fluorene as a substituent;
R32 and R33 are each independently a hydrogen atom, or C1-6 alkyl optionally substituted with a group selected from the group consisting of C1-6 alkoxycarbonyl and 5- to 10-membered heteroaryl; or alternatively, R32 and R33, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl;
R34 and R35 are each independently a hydrogen atom, C1-6 alkyl optionally substituted with a group selected from hydroxy and C1-6 alkoxy, 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q, C3-6 cycloalkyl, or C1-6 alkoxy; or alternatively, R34 and R35, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q;
R36 and R37 are each independently a hydrogen atom, C1-6 alkyl, or 4- to 6-membered heterocyclyl optionally substituted with a group selected from Group Q; or alternatively, R36 and R37, together with the nitrogen atom to which they are bonded, form 4- to 6-membered heterocyclyl optionally substituted with a substituent selected from Group Q;
Group P is a halogen atom, cyano, hydroxy, —NR50R51, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, 5- to 10-membered heteroaryl, and or C1-6 haloalkyl;
where R50 and R51 are each independently a hydrogen atom or C1-6 alkyl;
Group Q is cyano, a halogen atom, C1-6 alkyl which optionally has a substituent, C1-6 alkoxy, C3-6 cycloalkyl, 4- to 6-membered heterocyclyl which optionally has oxo as a substituent, C1-6 alkylcarbonyl, C1-6 alkylsulfonyl, C3-6 cycloalkylsulfonyl, C1-6 alkyloxycarbonyl, amino-C1-6 alkylcarbonyl, oxo, thioxo, hydroxy, or —NR52R53;
where the substituent in the C1-6 alkyl which optionally has a substituent selected from a halogen atom, hydroxy, 5- to 10-membered heteroaryl, and C6-10 aryl, where the C6-10 aryl optionally has hydroxy as a substituent;
R52 and R53 each independently represents a hydrogen atom, C1-6 alkyl, C1-6 alkylsulfonyl which may have optionally has a halogen atom as a substituent, C6-10 arylsulfonyl, C6-10 aryl-C1-6 alkylsulfonyl, or —C(O)OR54,
R54 represents C1-6 alkyl which optionally has a group selected from phenyl, fluorene, and 5- to 10-membered heteroaryl as a substituent; and
Group R is a halogen atom, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, nitro, or —NR60R61 {where R60 and R61 are identical or different, and are each a hydrogen atom, optionally substituted C1-6 alkyl (in which the substituent is hydroxy, C1-6 alkoxycarbonyl, carboxyl, or carboxamide), or amino-C1-6 alkyl; or alternatively, R60 and R61, together with the nitrogen atom to which they are bonded, form a 4- to 6-membered heterocycle},
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,479,779

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

NERVIANO MEDICAL SCIENCES...

1. A method for treating a disease selected from the group consisting of acute megakaryoblastic leukemia; transplant rejection, rheumatoid arthritis, psoriasis, Crohn's disease, ulcerative colitis, atopic dermatitis, solid tumors, myelofibrosis, myeloproliferative disorders, Polycythemia Vera (PV), Essential Thrombocythemia (ET), acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute lymphoblastic leukemia (ALL), the method comprising administering to a mammal in need thereof an effective amount of a compound of formula (I):
wherein:
Ring W is a pyrrole;
R1 is a substituted aryl;
R2 is CONR6R7 wherein R6 and R7 are independently hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, or R6 and R7, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 5 to 7 membered heterocyclyl group optionally containing one additional heteroatom selected from N, O and S;
R3 is hydrogen, halo or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R4 is an optionally substituted group

wherein:
R8 is hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, COR9, CONR10R11 and SO2R12,
wherein:
R9 is a group optionally substituted selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R10 and R11 are independently hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, or R10 and R11, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 5 to 7 membered heterocyclyl group optionally containing one additional heteroatom selected from N, O and S;
R12 is a group optionally substituted selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R5 is hydrogen, halo or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, heterocyclyl and heterocyclyl-alkyl;
or the pharmaceutically acceptable salts thereof.

US Pat. No. 10,479,778

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

NERVIANO MEDICAL SCIENCES...

1. A compound of formula (I):
wherein:
Ring W is a pyrrole;
R1 is a substituted aryl;
R2 is CN or CONR6R7 wherein R6 and R7 are independently hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, or R6 and R7, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 5 to 7 membered heterocyclyl group optionally containing one additional heteroatom selected from N, O and S;
R3 is hydrogen, halo or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R4 is an optionally substituted heteroaryl group selected from

wherein:
R8 is hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, COR9, CONR10R11 and SO2R12,
wherein:
R9 is a group optionally substituted selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R10 and R11 are independently hydrogen or an optionally substituted group selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl, or R10 and R11, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted 5 to 7 membered heterocyclyl group optionally containing one additional heteroatom selected from N, O and S;
R12 is a group optionally substituted selected from straight or branched C1-C6 alkyl, straight or branched C2-C6 alkenyl, straight or branched C2-C6 alkynyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl and heterocyclyl-alkyl;
R5 is hydrogen, halo or an optionally substituted group selected from straight or branched C1-C6 alkyl, C3-C7 cycloalkyl, cycloalkyl-alkyl, heterocyclyl and heterocyclyl-alkyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,479,777

HERBICIDAL AZINES

BASF SE, Ludwigshafen (D...

11. A process for preparing an azine of claim 1, wherein R1 and R5 independently of one another are H, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl or C1-C6-alkoxy; and A, R2, R3 and R4 are as defined in claim 1;comprising reacting a halotriazine of formula (II),

wherein R5 is H, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl or C1-C6-alkoxy; and
Hal is halogen;
with an amine of formula (III),
A-NHR1  (III),
wherein R1 is H, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl or C1-C6-alkoxy;
in the presence of a base and a catalyst.

US Pat. No. 10,479,775

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Mitobridge, Inc., Cambri...

1. A compound having the structure of Formula (Ibb):
or a pharmaceutically acceptable salt thereof, wherein:
R1 is hydrogen, halogen, —C1-C4-alkyl, —C1-C4-haloalkyl, —CN, —C1-C4-alkoxy, —C1-C4-haloalkoxy, or —C3-C6-cycloalkyl;
R2 is hydrogen, halogen, —CN, —C1-C4-alkyl, —C1-C4-haloalkyl, —C3-C6-cycloalkyl, —C1-C4-alkoxy, —C1-C4-haloalkoxy, —S(C1-C4-alkyl), —SO2(C1-C4-alkyl), 5- or 6-membered heterocyclyl, aryl, 5-membered heteroaryl, —?—R2A, —O(CH2)mR2B, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, or —C(O)(C1-C4-alkyl), wherein aryl and heteroaryl are optionally substituted with halogen, —OH, —CN, C1-C4-alkyl, formyl, acetyl, acetoxy, or carboxy, and wherein m is an integer having value of 1, 2, or 3;
R2A and R2B are each independently —C1-C4-alkyl, —C1-C4-haloalkyl, or —C3-C6-cycloalkyl;
each R20 is independently hydrogen, halogen, —C1-C4-alkyl, —CN, or —C1-C4-alkoxy; and
x is an integer having a value of 1 or 2.

US Pat. No. 10,479,772

3-ARYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X1 is O;
X2 and X4 are each CR1R2;
X3 is CR1?R2?;
Y1 and Y4 are not bonded to —C(O)NHOH and are each independently N or CR1;
Y2 and Y3 are each independently N or CR1 when not bonded to —C(O)NHOH, and Y2 and Y3 are C when bonded to —C(O)NHOH;
wherein one of Y1, Y2, Y3, and Y4 is N;
L is selected from the group consisting of —C(O)—, —C(O)(CR1R2)m, and —C(O)(CR1R2)mO—, wherein L is bound to the ring nitrogen through the carbonyl group;
R is independently, and at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, —O5—C12 spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, with the proviso that R is not bound to L via a nitrogen atom;
each R1 and R2 are independently, at each occurrence, selected from the group consisting of —H, —R3, —R4, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2C1-C6 alkyl, —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
each R1? and R2? are independently selected from the group consisting of H, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R3, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein at least one of R1? or R2? is not H;
R3 and R4 are independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, and —(CHR5)nN(C1-C6 alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6 alkyl), —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, —S(O)R5, —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
R5 is independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)SO2C1-C6 alkyl, —S(O)(C1-C6 alkyl), —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)(C1-C6 alkyl) and —(CH2)nN(C1-C6 alkyl)2;
each n is independently and at each occurrence an integer from 0 to 6; and
each m is independently and at each occurrence an integer from 1 to 6.

US Pat. No. 10,479,771

PYRIDAZINONE AND PYRIDONE COMPOUNDS

BIOTIE THERAPIES CORPORAT...

1. A method for treating a SSAO/VAP-1 related disease comprising administering to a patient in need thereof an effective amount of a composition comprising a compound of general formula (I?), or pharmaceutically acceptable salt, hydrate, or solvate thereof,
wherein
X is CH;
R1 is phenyl, optionally substituted with R11,
wherein R11 is selected from the group consisting of halogen, halo-C1-3-alkyl, and C1-6-alkoxy;
R2 is H or triazolyl;
(i) X3 is O or S, and
R3 is selected from the group consisting of H, C1-6-alkyl, C2-6-alkenyl, and phenyl, said phenyl being optionally substituted one or more times with R31, each R31 is independently selected from the group consisting of halogen, halo-C1-3-alkyl and C1-6-alkoxy; or
(ii) X3 is NR3?, and
R3 and R3? together with the nitrogen, to which they are attached, form a 5 or 6 membered saturated heterocyclic ring, —N3, or triazole, said triazole being optionally substituted with R32, wherein R32 is selected from the group consisting of phenyl, C1-6-alkyl, and —CO2(C1-3-alkyl); or
R3? is H or C1-3-alkyl, and
R3 is selected from the group consisting of H; C1-6-alkyl; C2-6-alkenyl; C2-6-alkynyl; C3-6-cycloalkyl-C1-6-alkyl; C3-6-cycloalkyl; cyano-C1-6-alkyl; amino-C1-6-alkyl; benzyl; pyridyl; saturated 5 or 6 membered heterocyclic ring having 1 to 2 heteroatoms selected from N, O, and S, and wherein said N is optionally substituted with C1-6-alkyl; R33R33?N—C1-6-alkylenyl; and phenyl, said phenyl being optionally substituted 1 to 3 times with R34;
wherein
R33 and R33? are both C1-3-alkyl, or R33 and R33? together with the nitrogen, to which they are attached, form a saturated 5 or 6 membered heterocyclic ring optionally comprising one further heteroatom selected from N, O, and S;
each R34 is independently selected from the group consisting of NR35R35?, hydroxy and C1-6-alkoxy; or two adjacent R34 together with the carbon atoms, to which they are attached, form a 5 or 6 membered fused heterocyclic ring comprising 1 or 2 heteroatom(s) each independently selected from N, O and S;
wherein R35 and R35? are both H or C1-6-alkyl; or R35 and R35? together with the nitrogen, to which they are attached, form a 5 or 6 membered saturated heterocyclic ring optionally further comprising as a ring member O, S, N, or NR36, wherein R36 is H, C1-6-alkyl or benzoyl;
R4 is selected from the group consisting of —CN; —C(?O)X4R41; phenyl, wherein said phenyl is optionally substituted with R42; and an 5 or 6 membered unsaturated heterocyclic ring having 1 to 4 heteroatoms each independently selected from N, O and S and being optionally substituted one or more times with R43;
wherein X4 is 0, S, or NH; and
R41 is selected from the group consisting of H, C1-6-alkyl, R44R44?N—C1-6-alkylenyl, and —NHR45,
wherein R44 and R44? are both H or C1,6-alkyl; or R44 and R44? together with the nitrogen, to which they are attached, form a 5 or 6 membered saturated heterocyclic ring; and
R45 is H or imino-C1-6alkyl; or
X4 and R41 taken together form —N?CR46R47, wherein
R46 is H or methyl, and
R47 is di(C1-3-alkyl)amino;
R42 is selected from the group consisting of halogen, halo-C1-3-alkyl, and C1-6-alkoxy;
each R43 is independently selected from the group consisting of OH, SH, and methyl, and
wherein the SSAO/VAP-1 related disease is selected from the group consisting of diabetic kidney disease, renal fibrosis, neointimal and medial fibrosis, vascular stenosis, restenosis, arterial fibrosis, arthrofibrosis, liver fibrosis, arthritis, multiple sclerosis and lung inflammation.

US Pat. No. 10,479,767

SUBSTITUTED HETEROARYL COMPOUND, COMPOSITION CONTAINING SAME, AND APPLICATION THEREOF

Shenzhen TargetRx, Inc., ...

1. A substituted heteroaryl compound, which is a heteroaryl compound represented by Formula (I), or a pharmaceutically acceptable salt thereof,
wherein R1, R2, R9, R10, R11, R12, and R13 are each independently hydrogen, or deuterium; and
R3, R4, R5, R6, R7, and R8 are each hydrogen;
provided that at least one of R1, R2, R9, R10, R11, R12, and R13 is deuterium.

US Pat. No. 10,479,766

DEUTERATED CFTR POTENTIATORS

Verex Pharmaceuticals (Eu...

1. A process for preparing Compound 106
or a pharmaceutically acceptable salt thereof, comprising reacting Compound 12

with Compound 6

wherein any atom not designated as deuterium is present at its natural isotopic abundance, wherein the percentage of isotopic enrichment for each designated deuterium is at least 90%, and
optionally treating Compound 106 with a base to produce a pharmaceutically acceptable salt of Compound 106.

US Pat. No. 10,479,765

SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS

BAYER PHARMA AKTIENGESELL...

1. A method for treatment of idiopathic pulmonary fibrosis in a human or an animal, comprising administering to the human or animal in need thereof a compound of the formula (I)
in which
RA is hydrogen, halogen, pentafluorosulfanyl, cyano, nitro, (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, amino or a group of the formula —NH—C(?O)—R6, —NH—C(?O)—NH—R6 or —S(?O)—R7,
where (C1-C4)-alkyl and (C1-C4)-alkoxy may be up to trisubstituted by fluorine,
and in which
R6 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R7 is (C1-C4)-alkyl which may be substituted by hydroxyl, methoxy or ethoxy or up to trisubstituted by fluorine,
and
n is the number 0, 1 or 2,
D is C—Rb or N,
E is C—RE or N,
G is C—RG or N,
where not more than two of the ring members D, E and G at the same time are N,
and in which
RD and RE are each independently hydrogen, fluorine, chlorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy,
and
RG is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl,
Z is OH or a group of the formula —NH—R8, —NH—SO2R9 or —NH—SO2—NR10AR10B, in which
R8 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R9 is (C1-C4)-alkoxy which may be up to trisubstituted by fluorine, or phenyl,
and
R10A and R10B are each independently hydrogen or (C1-C4)-alkyl which may be up to trisubstituted by fluorine,
R1 is halogen, trifluoromethoxy, (trifluoromethyl)sulfanyl, pentafluorosulfanyl, (C1-C4)-alkyl, trimethylsilyl, cyclopropyl or cyclobutyl,
where (C1-C4)-alkyl may be up to trisubstituted by fluorine
and
cyclopropyl and cyclobutyl may be up to disubstituted by fluorine,
R2, R3 and R4 are each independently hydrogen, fluorine, chlorine, methyl or trifluoromethyl,
R5 is (C1-C4)-alkyl which may be up to trisubstituted by fluorine, or is fluorine, chlorine, methoxy or cyclopropyl,
and
Ar is phenyl which may be mono- or disubstituted identically or differently by fluorine and chlorine, or is pyridyl or thienyl,and an N-oxide, salt, solvate, salt of the N-oxide and solvate of the N-oxide and salt thereof.

US Pat. No. 10,479,763

CHIRAL RESOLUTION METHOD OF N-[4-(1-AMINOETHYL)-PHENYL]-SULFONAMIDE DERIVATIVES

AMOREPACIFIC CORPORATION,...

1. A method for chiral resolution of a mixture of stereoisomers of a compound of formula (I),
wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently any one selected from a group consisting of H, —NH2, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group and a halogen, and R1 and R2 are different from each other,
comprising mixing said mixture of stereoisomers of the compound of formula (I) with
(i) a chiral auxiliary; and
(ii) an auxiliary salt-forming compound
in the presence of a solvent, thereby precipitating a diastereomeric salt of said chiral auxiliary (i) with the compound of formula (I) in enantiomeric excess,
wherein the chiral auxiliary is one or more selected from a group consisting of 2,3-dibenzoyltartaric acid, O,O?-di-p-toluoyltartaric acid, a stereoisomer thereof, and a combination thereof, and the auxiliary sal-forming compound is one or more selected from a group consisting of mandelic acid, camphorsulfonic acid, a stereoisomer thereof, and a combination thereof.

US Pat. No. 10,479,762

ZWITTERIONIC SURFACTANT CONTAINING ETHOXYLATE UNITS

King Fahd University of P...

1. A surfactant of formula (I)
or a tautomer thereof, or a stereoisomer thereof;
wherein:
R1 and R2 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl, and an optionally substituted cycloalkyl;
R3 and R4 are independently selected from the group consisting of an optionally substituted alkyl, and an optionally substituted cycloalkyl;
n is an integer in a range of 1-15;
x is an integer in a range of 5-21;
y is an integer in a range of 2-5; and
z is an integer selected from 3 and 4.

US Pat. No. 10,479,749

PROCESS FOR THE PREPARATION OF STANDARDIZED COMPOSITION OF ARJUNOGLUCOSIDE FROM THE BARK OF TERMINALIA ARJUNA

SAMI LABS LIMITED, Banga...

1. A process for the isolation of standardized composition comprising of arjunoglucoside from bark of Terminalia arjuna, said process comprising steps of:(a) Charging Terminalia arjuna bark powder into an extractor,
(b) Adding 3 volumes of ethanol or methanol to Terminalia arjuna bark powder and refluxing for 3 hours at 65 to 70° C.,
(c) Filtering the ethanol or methanol extract of step b) and concentrating under vacuum to get a brown coloured powder,
(d) Dissolving the powder obtained from step c) into 5 volumes of de-mineralize water and stirring thoroughly for 1 hr at 50-55° C. to obtain a solution,
(e) Transferring the solution from step d) to separating funnel and extracting with 2 volumes of ethyl acetate, 6 times, and separating the aqueous and organic layer,
(f) Collecting and combining the ethyl acetate fractions 1-6 from step e and concentrating under vacuum to obtain brown coloured powder,
(g) Loading the powder of step 1) into a silica gel and eluting with chloroform:methanol,
(h) Identifying the compounds from step g) as Arjunic acid corresponding to STR#1, Arjunolic acid corresponding to STR#2, Arjungenin corresponding to STR#3, Arjunoglucoside-I corresponding to STR#4, Arjunoglucoside-II corresponding to STR#5, Arjunetin corresponding to STR#6, and catechin corresponding to STR#7

US Pat. No. 10,479,743

PROCESS FOR THE SEPARATION OF ETHYLBENZENE

SCG Chemicals Company Lim...

1. A process for separation of ethylbenzene from a mixture comprising C8 aromatics comprising:distilling the mixture comprising C8 aromatics in the presence of an extractive agent;
wherein the extractive agent comprises a chlorinated aromatic compound and an organic compound selected from the group consisting of furandione derivatives and organic nitriles;
wherein the extractive agent comprises 5 to 20 percent by weight of the organic compound; and
wherein a weight ratio of the extractive agent to the mixture comprising C8 aromatics is in the range of 0.2:1 to 20:1.

US Pat. No. 10,479,740

PROCESS TO PREPARE PROPYLENE

GASOLFIN B.V., Amersfoor...

1. A process to prepare propylene from a mixture of hydrocarbons by performing the following steps:(a) extracting aromatics from the mixture of hydrocarbons thereby obtaining a resulting mixture of hydrocarbons poor in aromatics,
(b) contacting the resulting mixture obtained in step (a) with a mixture of a heterogenous cracking catalyst and a heterogeneous dehydrogenation catalyst in a fixed bed thereby obtaining a cracked effluent,
(c) separating propylene from the cracked effluent thereby also obtaining a higher boiling fraction, and
(d) recycling a first recycle stream comprising between 10 and 30 wt % of the higher boiling fraction to step (a) and a second recycle stream comprising a portion of the higher boiling fraction to step (b), wherein the first recycle stream and the second recycle stream each comprise aromatic compounds originating from the higher boiling fraction.

US Pat. No. 10,479,739

INTEGRATED SYSTEM FOR OXYGEN RECOVERY FOR DEEP SPACE MISSION

HONEYWELL INTERNATIONAL I...

1. An environmental control system, comprising:a carbon dioxide source;
a compressor downstream of the carbon dioxide source;
a Sabatier reactor downstream of the compressor, wherein the Sabatier reactor produces methane and water;
a water separator downstream of the Sabatier reactor, wherein the water separator produces methane and water;
a pyrolysis assembly downstream of the water separator and upstream of the compressor, wherein the pyrolysis assembly includes a pre-form that adheres carbon and has a surface area/volume ratio of at least 20 cm?1, wherein the pyrolysis assembly produces hydrogen;
an oxygen generating assembly (OGA) directly downstream of the water separator, wherein the OGA produces hydrogen and oxygen; and
wherein hydrogen produced from the OGA mixes with carbon dioxide exiting the compressor and before the exiting carbon dioxide enters the Sabatier reactor.

US Pat. No. 10,479,738

COMPOSITIONS USABLE AS FLARE COMPOSITIONS

Northrop Grumman Innovati...

1. A composition, comprising:a fuel;
a perfluoropolyether (PFPE) having a chemical structure of HO(CH2CH2O)nCH2CF2O(CF2CF2O)p(CF2O)qCF2CH2(OCH2CH2)nOH and a fluorine content of about 57% by weight of the PFPE, where n is an integer between 1 and 10, p is an integer between 1 and 50, and q is an integer between 1 and 50; and
an isocyanate compound,
the PFPE comprising from about 15 wt % to about 35 wt % of the composition.

US Pat. No. 10,479,734

METHOD AND APPARATUS FOR THERMALLY DEBINDERING A CELLULAR CERAMIC GREEN BODY

Corning Incorporated, Co...

1. A method for debindering a cellular ceramic green body comprising a top face and a bottom face with axial honeycomb channels extending therebetween, the method comprising:heating the green body in a circulating oxygen-containing atmosphere; and
selectively restricting circulation of the circulating oxygen-containing atmosphere to the green body with a flow modulation sleeve around a side of the cellular ceramic green body;
wherein the sleeve comprises a honeycomb body having a cavity into which the cellular ceramic green body can be placed.

US Pat. No. 10,479,731

METHOD FOR PYROLYZING PRECERAMIC POLYMER MATERIAL USING ELECTROMAGNETIC RADIATION

United Technologies Corpo...

1. A method for fabricating a ceramic material from a preceramic polymer material, the method comprising:providing a preceramic polymer material that includes a preceramic polymer and an electromagnetic radiation-responsive component, the electromagnetic radiation-responsive component includes a metal selected from the group consisting of cobalt, zirconium, hafnium, tantalum, rhenium, and combinations thereof, wherein the preceramic polymer includes, by volume, 0.1-10% of the electromagnetic radiation-responsive component; and
applying electromagnetic radiation to the preceramic polymer material, the electromagnetic radiation interacting with the electromagnetic radiation-responsive component to generate heat that converts the preceramic polymer to a ceramic phase.

US Pat. No. 10,479,729

SHADED ZIRCONIA CERAMIC MATERIAL AND MACHINABLE SINTERED CERAMIC BODIES MADE THEREFROM

James R. Glidewell Dental...

1. A sintered ceramic body suitable for use in dental restoration applications comprising:a. a ceramic material that comprises zirconia and
b. a coloring agent comprising 0.002 mass % to 0.65 mass % of terbium (Tb) and chromium (Cr) combined, measured as metal ions,
wherein the mass ratio of Tb to Cr, measured as metal ions, is in the range of approximately 93:7 Tb:Cr to approximately 99.5:0.5 Tb:Cr.

US Pat. No. 10,479,723

WINDOW WITH UV-TREATED LOW-COATING AND METHOD OF MAKING SAME

GUARDIAN GLASS, LLC., Au...

21. A method of making a coated article for use in a window, the method comprising:having a coated article including a glass substrate that supports a coating, the coating comprising at least one layer comprising silver located directly on and contacting a layer comprising zinc oxide, the coating further comprising a dielectric layer between at least the layer comprising zinc oxide and the glass substrate, and at least one upper dielectric layer located over at least the layer comprising silver so that the layer comprising silver is located between at least the upper dielectric layer and the glass substrate;
directing UV radiation from at least one UV source toward the coating and exposing the coating to UV radiation in order to reduce a sheet resistance of the coating;
wherein the layer comprising zinc oxide has a bandgap of from about 3.2 to 3.4 eV; and
wherein the coating has a sheet resistance (Rs) of no greater than 10 ohms/square after said UV exposing.

US Pat. No. 10,479,722

PROCESS FOR PRODUCING STRUCTURED COATINGS

Evonik Degussa GmbH, Ess...

1. A process for producing a structured coating, comprising:applying
a. a coating composition comprising
i. at least one inorganic binder,
ii. at least one oxide pigment which, after addition of a mixture consisting of 15 ml of 1 M oxalic acid and 15 ml of 20% aqueous hydrochloric acid based on 1 g of substance, under standard conditions, leads to a temperature rise of at least 4° C., and
iii. at least one solvent
to a substrate, to obtain a coating composition film on the substrate,
b. partially coating the resulting coating composition film with a photoresist, and
c. treating the substrate coated with the coating composition film and the photoresist with an acid resulting in a leaching out of said at least one oxide pigment from said coating composition film leaving a leached layer.

US Pat. No. 10,479,719

APPARATUS AND METHOD FOR CUTTING A GLASS SHEET

Corning Incorporated, Co...

1. A method of cutting a glass sheet, the method comprising:heating a heating element to a heat temperature;
positioning the glass sheet immediately adjacent to the heating element such that a cutting line of the glass sheet is aligned with the heating element;
engaging the glass sheet with a sharp-edged tool without forming a defect in the glass sheet; and
maintaining the glass sheet in position immediately adjacent to the heating element and engaged by the sharp-edged tool without relative motion between the glass sheet and the sharp-edged tool after engaging the glass sheet with the sharp-edged tool, whereby the glass sheet separates along the cutting line.

US Pat. No. 10,479,717

GLASS FOAM

Owens-Brockway Glass Cont...

1. A method of producing a glass foam, the method comprising:obtaining a dried glass precursor gel comprising nanometer-sized pores and a bulk amorphous oxide-based matrix having an inorganic network of primary constituent oxides, the primary constituent oxides comprising 30 mol % to 90 mol % silica (SiO2) and one or more of the following: (A) 0.1 mol % to 25 mol % of one or more alkali oxides in sum total, (B) 0.1 mol % to 30 mol % of one or more alkaline earth oxides in sum total, (C) 1 mol % to 25 mol % boric oxide, (D) 5 mol % to 80 mol % lead oxide, or (E) 0.1 mol % to 15 mol % aluminum oxide;
heating the dried glass precursor gel to a temperature below the melting point of the gel; and
maintaining the temperature for a time sufficient to expand the dried glass precursor gel; and
expanding the dried glass precursor gel to form a glass foam.

US Pat. No. 10,479,716

BIOREFINERY METHOD AND SYSTEM FOR ISOLATED ENVIRONMENTS

University of Louisiana a...

1. A method for treating waste comprising the steps of:a. metabolically decomposing chemical oxygen demand of solid and liquid influents through anaerobic bacteria digestion, wherein said decomposition produces products comprising hydrogen, methane, liquid effluents, and solid effluents;
b. directing said liquid effluents and solid effluents into a tank, said tank housing aerobic bacteria, wherein said aerobic bacteria convert an organic fraction of said effluents into lipid-enriched content microbial solids and produce liquid-phase and gaseous-phase effluents;
c. employing a growth algal reactor wherein green algae attached to a turf matrix to remove nutrients from said liquid-phase effluent and scrub carbon dioxide from said gaseous effluents and wherein said employing step produces whole cells;
d. extracting lipids from said microbial solids and said whole cells; and
e. removing any residual chemicals from said liquid-phase and said gaseous-phase effluents using advanced adsorption polishing with a functionalized mesoporous adsorbent bed.

US Pat. No. 10,479,715

PROCESS FOR THE TREATMENT OF HIGH SULPHATE WATERS

1. A process for the treatment of sulphate-containing water, the process including:a first reaction stage within which ettringite is used to precipitate precipitated solids from the sulphate-containing water, the precipitated solids being selected from the group consisting of metal compounds, phosphate compounds, sulphate compounds and combinations thereof;
a suspended solids removal stage for removal of the precipitated solids produced by the first reaction stage;
a further reaction stage including ettringite production from partially-treated sulphate-containing water from the first reaction stage and the addition of an aluminum containing reagent;
a suspended solids removal stage for removal of precipitated solids produced by the further reaction stage;
a particle separation stage within which some or all of the precipitated solids that are removed within the suspended solids removal stage are separated into an aluminum hydroxide-rich product and a product containing a remainder of the precipitated solids removed by the suspend solids removal stage; and
recovery to the further reaction stage of a portion or all of the aluminum hydroxide-rich product as at least a portion of the aluminum containing reagent; and
recovery of the ettringite produced by the further reaction stage for use in the first reaction stage.

US Pat. No. 10,479,710

GRANULE-FORMING METHOD AND WASTE WATER TREATMENT METHOD

ORGANO CORPORATION, Toky...

1. A granule-forming method using a semi-batch reaction tank, the method comprising forming granules by repeatedly performing an operation cycle having an introduction step of introducing an organic matter-containing wastewater, a biological treatment step of biologically treating treatment target substances in the organic matter-containing wastewater by using a microbiological sludge, a settling step of allowing the microbiological sludge to settle, and a discharge step of discharging a biologically treated water that has been biologically treated, whereinthe operation cycle includes a first operation cycle for performing the biological treatment step at a first sludge load, and a second operation cycle, performed after the first operation cycle, for performing the biological treatment step at a second sludge load, and
the first sludge load is set such that a soluble BOD concentration inside the semi-batch reaction tank upon completion of the biological treatment step of the first operation cycle does not fall to a threshold value or below, and the second sludge load is set such that a soluble BOD concentration inside the semi-batch reaction tank upon completion of the biological treatment step of the second operation cycle does not exceed a threshold value.

US Pat. No. 10,479,708

WASTE TREATMENT SYSTEM

EPIC CLEANTEC INC., San ...

1. A waste treatment method using a waste treatment system located in or near a commercial or multiple-unit residential building, comprising:removing water from solid waste in a liquid separator, thereby reducing water content of the solid waste to 30% or less;
transferring the solid waste from the liquid separator to a mixing tank connected to the liquid separator;
transferring the water from the liquid separator to a sanitization tank;
mixing the solid waste having a water content of 30% or less with an oxidizing agent in the mixing tank to cause an exothermic reaction and convert the solid waste to processed solid waste;
collecting heat from the exothermic reaction in a heat exchanger coupled with the mixing tank;
sanitizing the water from the liquid separator in the sanitizing tank; and
intermittently diverting the waste from a building sewer system away from the waste treatment system into a public sewer system.

US Pat. No. 10,479,703

METHOD FOR REDUCING ARSENIC CONCENTRATION IN AQUEOUS SOLUTIONS

IMPERIAL COLLEGE INNOVATI...

1. A method of reducing the arsenic concentration in an aqueous solution that comprises arsenic, which method comprises contacting the aqueous solution with a complex of Formula I,
wherein M1 and M2 are the same or different and are independently selected from V, Mn, Ga, Cu, Ni, Co, Fe or Zn; wherein a is 0, or 1, and b is 0, or 1, provided that a+b together must be at least 1;
Q is a negatively charged counter ion, wherein the negatively charged counter ion is NO3?, ClO4?, AcO?, PF6?, BF4?, Cl?, BPh4? or Br?;
n is from 1 to 5;
X1 is OH, O, SH or S;
L1 is a group selected from -La1-C(O)NR—, -La2-C(O)OR—, -La3-NRC(O)—, La4-OC(O)—, La5-O— or La6-NRO—, wherein La1, La2, La3, La4, La5 and La6 are each C1-6 alkyl, optionally substituted, R is H or C1-6 alkyl optionally substituted;
Linker is a polyethylene glycol (PEG) chain with from 1 to 10 repeating units, a C1-16 polyamine chain or a C1-16 alkyl chain;
Z is a solid support;
L2 to L7 are independently C1-3 alkyl, optionally substituted; and
Het1 to Het4 are independently 5 to 14 membered heteroaryl group having at least one N atom and optionally substituted.

US Pat. No. 10,479,702

CLEANING MODULE, FILTER ELEMENT AND FILTER SYSTEM

1. A filter system for filtering a media flow comprising:a filter system housing having a connecting part projecting outwardly from the filter system housing;
a first and second medium having a separating device for the first medium arranged in the filter system housing; and
a cleaning module for cleaning a media flow of a first medium contaminated with a second medium for the absorptive and/or adsorptive pickup of a portion of the second medium in the separated-out first medium,
wherein the cleaning module is a cartridge having a base portion which rests on and is detachably joined to the connecting part of the filter system housing, the cleaning module removable from the filter system housing for maintenance, the cleaning module including:
a cleaning module housing having an inlet for the media arranged at the base portion; and
an outlet for the media flow arranged at an upper portion of the cleaning module housing; and
a replaceable filter element arranged within the cleaning module housing,
wherein a flow direction of the media flow is directed through the filter element in the specified installed state against the force of gravity,
wherein the filter element has an absorptive and/or adsorptive material configured for picking up at least a portion of the second medium in the first medium,
wherein media flow enters the inlet at the base portion of the cleaning module from the connecting part of the filter system housing, the media flow flowing upwardly in the cleaning module against gravity to the outlet of the cleaning module, wherein media flow pressure in the cleaning module is limited by and only sufficient to raise the media flow against gravity from the inlet to the outlet of the cleaning module.

US Pat. No. 10,479,696

METHOD FOR PREPARING MOLYBDENUM OXIDE NANOPARTICLES

University-Industry Coope...

1. A method for preparing molybdenum oxide nanoparticles, comprising:(a) preparing a precursor solution by dissolving a molybdenum salt in a first polar solvent;
(b) generating an aerosol by applying ultrasonic waves to the precursor solution, and spraying the aerosol to a pre-heated reactor using a carrier gas;
(c) obtaining molybdenum oxide micron-sized particles by pyrolyzing the aerosol; and
(d) obtaining molybdenum oxide nanoparticles by dispersing the molybdenum oxide micron-sized particles in a second polar solvent and performing a solvothermal reduction reaction,
wherein the molybdenum oxide micron-sized particles are polycrystalline,
wherein a BET specific surface area of the molybdenum oxide nanoparticles is at least 100 m2/g.

US Pat. No. 10,479,692

ZEOLITE PRODUCTION METHOD

1. A method of producing a zeolite comprising:reacting a gel and zeolite seed crystals to produce a zeolite having the same kind of skeletal structure as the zeolite seed crystals;
wherein:the gel comprises a silica source, an alumina source, an alkali source and water;the gel is capable of synthesizing a zeolite without the use of the zeolite seed crystals, wherein the zeolite synthesized without the use of the zeolite seed crystals comprises one or more building units of zeolite;the zeolite seed crystals comprise one or more composite building units of zeolite;the zeolite seed crystals and the zeolite synthesized without the use of zeolite seed crystals comprise at least one equivalent composite building unit of zeolite;wherein the reacting step occurs without the use of an organic structure-directing agent;
wherein the zeolite produced is beta zeolite;
wherein the gel has a composition of:
SiO2/Al2O3=12 to 20,
Na2O/SiO2=0.1 to 0.25,
H2O/SiO2=10 to 25,
and wherein an amount of the zeolite seed crystals is 1 weight % to 20 weight % with respect to the silica component included in the gel.

US Pat. No. 10,479,691

METHOD FOR RECOVERING SILICA FROM SILICA-CONTAINING PLANT BODY USING TITANIUM OXIDE

Rapas Corporation, Shiga...

1. A recovery method for silica, comprising bringing heated titanium oxide comprising titanium oxide granules into contact with a silica-containing plant body to obtain said silica, wherein the silica is 98% (wt) or more soluble silica and wherein the titanium oxide granules have the following characteristic (1) or (2):(1) a particle size distribution in the following range:
titanium oxide granules each having a particle size of 1.2 mm or more account for from 1 wt % to 50 wt %;
titanium oxide granules each having a particle size of from 0.5 mm to 1.2 mm account for from 40 wt % to 90 wt %; and
titanium oxide granules each having a particle size of 0.5 mm or less account for from 1 wt % to 20 wt %; or
(2) a particle size distribution in the following range:
titanium oxide granules each having a particle size of 1.2 mm or more account for from 10 wt % to 60 wt %; andtitanium oxide granules each having a particle size of from 0.5 mm to 1.2 mm account for from 40 wt % to 90 wt %.

US Pat. No. 10,479,685

ENRICHED ACID GAS FOR SULFUR RECOVERY

Saudi Arabian Oil Company...

1. A method of sulfur enriching an acid gas stream in an acid gas enrichment system, the method comprising:feeding an acid gas stream to an acid gas stream connector and thereafter to a contactor, the acid gas stream comprising hydrogen sulfide (H2S), carbon dioxide (CO2), and hydrocarbons;
separating the acid gas stream in the contactor to obtain a carbon dioxide rich stream and a purified acid gas stream;
feeding the purified acid gas stream to a regenerator fluidly connected to the contactor;
separating the purified acid gas stream in the regenerator to obtain a hydrogen sulfide rich stream and a hydrogen sulfide lean stream, the hydrogen sulfide rich stream having a concentration of hydrogen sulfide; and
periodically feeding at least a portion of the hydrogen sulfide rich stream exiting the regenerator through a recycle valve positioned along a fluid pathway upstream of the acid gas stream connector to combine with the acid gas stream prior to the combination of the hydrogen sulfide rich stream and the acid gas stream entering the contactor,
wherein the periodically feeding comprises adjusting the recycle valve to direct the hydrogen sulfide rich stream exiting the regenerator to combine with the acid gas stream at the acid gas stream connector prior to the combination of the hydrogen sulfide rich stream and the acid gas stream entering the contactor, and
wherein the adjusting the recycle valve comprises opening or closing the recycle valve based on an H2S content in the hydrogen sulfide rich stream.

US Pat. No. 10,479,682

COMPOSITION AND METHOD FOR GENERATING OXYGEN FROM PEROXIDES IN IONIC LIQUIDS

Diehl Aviation Gilching G...

1. A composition for generating oxygen, comprising at least one oxygen source,at least one ionic liquid, and
at least one metal salt, wherein
the oxygen source comprises a peroxide compound,
the ionic liquid is in the liquid state at least in a temperature range from ?10° C. to +50° C., and
the metal salt comprises one single metal or two or more different metals, and an organic and/or an inorganic anion, and
the at least one oxygen source, the at least one ionic liquid, and the at least one metal salt, upon coming into contact with one another, forming a composition that generates breathable oxygen for human breathing.

US Pat. No. 10,479,680

ELECTRICALLY HEATED STEAM REFORMING REACTOR

Raven SR, LLC, Pinedale,...

1. A method for high temperature gasification, comprising:flowing a stream of a first hydrocarbon gas from an entrance of a bottom annular plenum region toward an inlet at a bottom of an annular plenum, the bottom annular plenum region being discrete from the annular plenum;
flowing the stream of the first hydrocarbon gas from the bottom inlet toward a top outlet;
electrically heating the flowing first gas along the axial length of the annular plenum;
flowing the heated gas from the top outlet to a top inlet of a cylindrical plenum and toward a bottom outlet;
electrically heating the flowing gas along the axial length of the cylindrical plenum;
converting the first hydrocarbon gas to a syngas by said heating in at least one of the annular or cylindrical plenums;
removing the syngas from the bottom outlet; and
transferring heat from the syngas proximate the bottom outlet to the first gas in the bottom annular plenum region;
wherein the annular plenum surrounds the cylindrical plenum.

US Pat. No. 10,479,679

EXHAUST GAS CLEAN-UP SYSTEM EQUIPPED WITH POWER GENERATING FUNCTION

ATSUMITEC CO., LTD., Shi...

1. An exhaust gas clean-up system equipped with a power generating function, comprising:a steam reforming unit to produce hydrogen from exhaust gas supplied,
a hydrogen permeable membrane configured to allow only hydrogen produced by the steam reforming unit to pass through it,
a hydrogen storage unit configured to absorb hydrogen supplied through the hydrogen permeable membrane and release absorbed hydrogen,
a fuel cell configured to generate power using hydrogen supplied from the hydrogen storage unit,
a gas clean-up unit configured to clean up residual gases not passing through the hydrogen permeable membrane,
a control unit configured to control the hydrogen storage unit to absorb or release hydrogen depending on whether the fuel cell is supplied with an operative amount of hydrogen,
a hydrogen delivery path extending from the hydrogen permeable membrane to the gas clean-up unit via the hydrogen storage unit and the fuel cell, and
a residual gas delivery path extending from the steam reforming unit to the gas clean-up unit bypassing the hydrogen storage unit and the fuel cell.

US Pat. No. 10,479,674

OSCILLATION FREQUENCY MEASURING SYSTEM AND METHOD FOR A MEMS SENSOR

STMICROELECTRONICS S.R.L....

1. A device, comprising:a semiconductor substrate having a first surface;
a light emitting device extending in the semiconductor substrate to a first distance from the first surface;
a light detector extending in the semiconductor substrate to a second distance from the first surface, the second distance being smaller than the first distance;
a movable element coupled to the semiconductor substrate and extending over the first surface of the substrate, the movable element having a surface that faces the first surface of the semiconductor substrate, the light emitting device, and the light detector, the surface of the moveable element being configured to reflect light from the light emitting device to the light detector.

US Pat. No. 10,479,670

LIQUID DISPENSING DEVICE

1. A beer dispensing device comprising a plurality of more than 100 tubes each tube having a diameter less than 0.75 mm, wherein each tube has a length in the range 40 to 7000 mm and wherein the tubes have a length:diameter ratio configured to establish laminar flow of the beer dispensed therethrough, in use; wherein the bores of the plurality of tubes are parallel with one another and the plurality of tubes are encased within an inner housing by friction-fit or by bonding.

US Pat. No. 10,479,669

BEVERAGE MAKING APPARATUS

LG Electronics Inc., Seo...

1. A beverage-making apparatus comprising:a container comprising:
a container body comprising heat-insulating material and having an opening that provides access to an interior of the container body; and
a container cover configured to open and close the opening of the container body;
a plurality of channels connected to the container and that are communicative with the interior of the container body, the plurality of channels comprising:
at least one first channel and a second channel that are communicative with a beverage ingredient pack mounted in the interior of the container body, the beverage ingredient pack configured to be accommodated in the interior of the container body,
wherein the beverage ingredient pack is configured to hold first beverage-making ingredients, the beverage ingredient pack configured to prevent the first beverage-making ingredients from contacting a wall of the container body,
wherein the at least one first channel communicative with the beverage ingredient pack mounted in the container body is configured to transport at least one of a liquid or a first gas,
wherein the second channel communicative with the beverage ingredient pack mounted in the container body is configured to transport a second gas,
wherein the at least one first channel is configured to transport a first liquid and a second liquid unidirectionally into and out of, respectively, the beverage ingredient pack, and to transport the first gas unidirectionally into the beverage ingredient pack, and
wherein the second channel is configured to transport the second gas unidirectionally out of the beverage ingredient pack.

US Pat. No. 10,479,668

AMBIENT FILLING SYSTEM AND METHOD

PepsiCo, Inc., Purchase,...

10. A method of producing a container filled with a carbonated fluid product, the method comprising:retaining treated water at an ambient temperature in a water tank;
deaerating the water tank using a vacuum pump to create a negative pressure of at least 0.8 bar;
mixing the treated water with a concentrate to create a fluid mixture;
injecting the fluid mixture with carbon dioxide at a pressure in a range of approximately 3.2 bar to approximately 4.2 bar to create the carbonated fluid product;
storing the carbonated fluid product in a carbonized tank that is fluidly connected to a filling machine, the carbonized tank having an interior pressure of approximately 5.5 bar;
operating the filling machine to fill the container with the carbonated fluid product, the filling machine having an interior pressure of approximately 5 bar, and the carbonated fluid product being at the ambient temperature.

US Pat. No. 10,479,667

APPARATUS AND METHOD FOR TREATING CONTAINERS AND PACKAGES WITH FLYING MACHINE FOR MONITORING

KRONES AG, (DE)

1. An apparatus for treating containers and/or packages, with a first treatment device which treats the containers and/or packages in a first predefined fashion, with a second treatment device which treats the containers and/or packages in a second predefined fashion, and with a transport device for transporting the containers and/or packages, and with a monitoring device for monitoring the apparatus,wherein
the monitoring device comprises an unmanned remote-controlled flying machine and a control device for wireless control of this flying machine, wherein the flying machine has an image-recording device and wherein the apparatus has a limiting device which limits a flying range of the flying machine, wherein the apparatus has a rest terminal to which the flying machine can fly in a rest position of the flying machine, and wherein the apparatus comprises a fault detector which is configured for detecting faults in the treatment devices, and the control device controls the flying machine as a function of a fault detected by the fault detection device and instructs the flying machine to fly to the areas of the faults.

US Pat. No. 10,479,666

SAMPLING CONTROL STATION FOR BOTTLES OR CONTAINERS FILLING PLANT

FT SYSTEMS S.R.L, Alseno...

1. Sampling control station (20) for a container or bottle filling plant having a filling and closing station said sampling control station comprising at least one grasping and transporting group (22) for picking up containers or bottles (16) from conveying means (18) and transporting said containers or bottles to at least one measuring module (21?, 21?, 21??) said container or bottle (16) being provided with a body tapered into a neck and ending with a mouth, said neck having an annular ribbing (19), characterised in that said grasping and transporting group (22) comprises gripping means (23) being connected to a mobile rotary support structure (30) said mobile rotary support structure (30) having a centre of rotation arranged at said conveying means (18), said at least one measuring module (21?, 21?, 21??) being arranged along a circumference described by the rotational movement of said gripping means (23) through said mobile rotary support structure (30), said mobile rotary structure being adapted to pick up said container or bottle (16) from said conveying means (18) with said grasping and transporting group (22) and to transport said container or bottle (16) to said at least one measuring module (21?, 21?, 21??) to then take said container or bottle (16) back again to a release point of said conveying means (18) once measurement has been carried out and no anomaly has been detected or to then position said container or bottle (16) at a discarding container in the case in which anomalies are found, said gripping means (23) comprising a pincer adapted to be opened and closed through a lever mechanism (27), said gripping means (23) being mobile between a gripping position, in which they are engaged with said neck of said container (16) at and below said annular ribbing (19), and a release position in which they are not engaged with said container (16), gripping means (23) means being connected to and supported by mobile support structure (30) in order to perform a gripping from above the neck of container (16), wherein said mobile support structure (30) is vertically translatable in order to adjust the suspension height of said gripping means (23) means and wherein said sampling control station also includes a removal or reclosing module (40) for measuring a removal torque and/or a reclosing angle of a cap (28) of said container (16) connected to said grasping and transporting group (22) so as to be positioned above said gripping means (23).

US Pat. No. 10,479,662

FORK POSITIONER WITH GUIDED FORK HOLDER

Rightline Equipment, Inc....

6. A fork positioning assembly comprising:a fork frame with a top bar, a bottom bar, a left side bar, and a right side bar;
a first fork positioner coupled to the left side bar and right side bar, the first fork positioner comprising a first tube with a first interior cavity, a first carrier positioned in the first interior cavity in sliding contact with the first tube, and a first fork holder external to the first tube, the first fork holder coupled to the first carrier through a first slot in the first tube;
a second fork positioner coupled to the left side bar and right side bar, the second fork positioner comprising a second tube with a second interior cavity, a second carrier in the second interior cavity slidingly contacting the second tube, and a second fork holder external to the second tube, the second fork holder coupled to the second carrier through a second slot in the second tube;
wherein the first fork positioner and the second fork positioner are vertically arranged with one above the other;
wherein the slot in the tube of the first fork positioner faces the bottom bar; and
wherein the slot in the tube of the second fork positioner faces the bottom bar.

US Pat. No. 10,479,661

LIFT AND PALLET

Rehrig Pacific Company, ...

1. A pallet lift comprising:a lift mechanism;
at least one inner tine secured to the lift mechanism;
at least one wheel supporting the at least one inner tine and spaced away from the lift mechanism along a longitudinal axis of the at least one inner tine;
a pair of outer tines secured to the lift mechanism positioned outward of the at least one inner tine, the pair of outer tines movable between an expanded position spaced outward away from the at least one inner tine and a retracted position adjacent the at least one inner tine; and
at least one outer wheel supporting each of the pair of outer tines, wherein each at least one outer wheel is capable of being lifted off a floor on which the at least one wheel supporting the at least one inner tine is supported, wherein the at least one outer wheel is liftable prior to the outer tines being moved to the expanded position from the retracted position.

US Pat. No. 10,479,660

WINDLASS SYSTEM AND METHOD WITH ATTENUATED STOP FUNCTION

1. A windlass system in which an inertial force resulting from an abrupt removal of primary operating power from a primary source of power during a lifting operation being carried out by a windlass of the windlass system is attenuated to reduce load forces generated by the inertial force, the windlass system comprising:a drivetrain arranged for rotation within the windlass to move a load during the lifting operation;
at least one safety brake arranged to engage the drivetrain for applying a rotation-retarding torque to the drivetrain;
a power detector for detecting the abrupt removal of primary operating power;
an auxiliary power supply for supplying auxiliary power upon detection by the power detector of the abrupt removal of primary operating power to actuate the safety brake to apply a rotation-retarding torque to the drivetrain in response to:
a brake torque control arranged for operation by auxiliary power from the auxiliary power supply; and
a drive controller for operation by auxiliary power from the auxiliary power supply in response to detection by the power detector of the abrupt removal of primary operating power to extend the rotation-retarding torque applied by the safety brake to the drivetrain over a predetermined interval, after which interval rotation of the drivetrain is discontinued and movement of the load is fully terminated, thereby effecting attenuation of the inertial force resulting from removal of the primary operating power.

US Pat. No. 10,479,659

MECHANISM TO SELECTIVELY FIX OR FREE PLANETARY CARRIER OF EPICYCLIC GEARBOX

Ingersoll-Rand Company, ...

1. A method for selectively fixing or freeing a planetary carrier of an epicyclic gearbox of a dual capacity winch, the method comprising:providing a dual capacity winch having a single epicyclic gearbox coupled to a drum of the winch, wherein the drum of the winch is supported by at least one stationary winch upright;
providing a first motor configured to drive a sun gear of the epicyclic gearbox so that the operation of the gear box, when the sun gear is driven, results in substantial torque multiplication;
providing a second motor configured to drive a planetary carrier of the epicyclic gearbox, so that the resulting gear ratio is significantly lower than when the sun gear is driven;
providing a brake to selectively prevent movement of the sun gear; and
providing a locking mechanism configured to engage and drive the planetary carrier of the epicyclic gearbox, wherein the locking mechanism includes a movable portion configured to:
selectively engage and lock with a shaft fixedly coupled with the planetary carrier while remaining locked against rotation by fasteners connected to at least one stationary winch upright, when the sun gear is driven; and
to selectively disengage and unlock from the shaft fixedly coupled with the planetary carrier, when the planetary carrier of the epicyclic gearbox is driven.

US Pat. No. 10,479,657

ADJUSTABLE LENGTH TENSIONING MEMBER

Manitowoc Crane Companies...

1. An adjustable length tensioning assembly comprising:a rope connector comprising:
a rope having a first end, a second end, and a first diameter;
a first rope connector disposed at the first end of the rope, the first rope connector configured to connect to a first crane component;
a second rope connector disposed at the second end of the rope, wherein the second rope connector comprises a safety hook having a load capacity less than a load capacity of the first rope connector; and
a plurality of connection points disposed between the first rope connector and the second rope connector, the plurality of connection points having a second diameter greater than the first diameter; and
a socket comprising:
a first end having a socket connector configured to connect to a second crane component;
a second end having a recess housing a portion of the rope connector, the recess having a first portion having a third diameter greater than the second diameter and a second portion having a fourth diameter greater than the first diameter and less than the second diameter, the transition from the first portion to the second portion forming a seat; and
an access slot extending laterally from a lateral side of the socket to the recess and axially the length of the recess, the access slot having a width greater than the first diameter and less than the second diameter.

US Pat. No. 10,479,655

INSTALLATION AND SUPPORT METHOD INCLUDING A TOWER CRANE FOR SUPPORTING A HIGH-VOLTAGE LINE ELECTRIC CABLE

Manitowoc Crane Group Fra...

1. A support installation for supporting at least one electric cable belonging to a high-voltage line, during implantation or maintenance work of the high-voltage line, the support installation comprising support members configured to support said at least one electric cable, and further comprising:a tower crane, the tower crane comprising a mast and a jib linked to an upper portion of the mast and rotatable relative to the mast, the jib extending according to a jib direction and the mast extending according to a mast direction which is substantially vertical when the support installation is in a service configuration,
wherein, the support members are secured to the jib and disposed at a plurality of locations spaced along to the jib direction, the support members extending substantially transversally to the jib direction so as to protrude laterally from the jib when the support installation is in the service configuration,
wherein, the jib is cantilevered when the support installation is in the service configuration,
wherein the support members are disposed at a plurality of locations along a length of the jib on each side of the jib and protrude laterally from each side of the jib, and
wherein each of the support members is displaceable between an unfolded configuration, in which each support member protrudes laterally from the jib, and a folded configuration, in which each support member is disposed adjacent the jib.

US Pat. No. 10,479,654

CRANE GIRDER FOR A CRANE

1. A crane girder for a crane, the crane girder comprising a hollow profile, having an external wall that encloses a cavity, and extends longitudinally, and the external wall, when viewed in a cross section through the crane girder, has at least in regions an outwardly bulging shape for reducing aerodynamic drag, the external wall, when viewed in the cross section through the crane girder, has two mutually opposite portions, having an outwardly bulging shape, which are interconnected by two mutually opposite straight wall portions of the external wall, and at least one running surface adapted to support at least one running wheel of a trolley of a lifting gear of the crane, the mutually opposite portions, having an outwardly bulging shape, in an operating position of the crane girder point upward and downward, and the straight wall portions in the operating position laterally delimit the crane girder, the straight wall portions extend vertically, the running surface is at least one of disposed or supported on one of the straight wall portions of the external wall, and a thickness extent of the external wall in a vertical direction, when viewed in the cross section through the crane girder, is between 50% and 80% of a width extent of the external wall in a horizontal direction.

US Pat. No. 10,479,650

ARRANGEMENT FOR REDUCING DISPLACEMENT OF AN ELEVATOR CAR CAUSED BY A CHANGE IN LOADING

KONE CORPORATION, Helsin...

1. An arrangement for reducing the displacement of an elevator car caused by a change in loading, comprising:the elevator car configured to move up and down in an elevator hoistway;
one or more counterweights;
at least one rope element essentially above the elevator car;
at least one rope element essentially below the elevator car; and
at least one pretensioner of the rope elements,
wherein the elevator car and one or more counterweights are configured to be supported and to be moved via the rope elements and the at least one pretensioner, and a plurality of rope pulleys, of which rope pulleys the first part are diverting pulleys, and the second part are traction sheaves or corresponding,
wherein the arrangement comprises at least two hoisting machines,
wherein the arrangement includes a locking mechanism configured to lock at least two rope pulleys to be non-rotating at least during loading of the elevator car,
wherein a first end of the at least one rope element below the elevator car is fixed to, via the pretensioner, a bottom end of one of the one or more counterweights or a bottom part of the elevator hoistway, a second end of the at least one rope element below the elevator car is led to pass around one or more of the plurality of rope pulleys, and the pretensioner is configured to provide a constant tensioning force to the at least one rope element below the elevator car, and
wherein the pretensioner includes:
a roll rotating around an axis of rotation;
an adjustment element fixed to the roll, the adjustment element rotating along with the roll and being eccentric with respect to the axis of rotation of the roll; and
a tensioning rope is configured to rotate the adjustment element under a tensioning force,
wherein the at least one rope element below the elevator car is fixed to an outer rim of the roll such that the first end of the at least one rope element below the elevator car can be coiled onto the roll when the roll rotates around the axis of rotation as the at least one rope element loosens.

US Pat. No. 10,479,648

AUTOMATIC ELEVATOR INSPECTION SYSTEMS AND METHODS

OTIS ELEVATOR COMPANY, F...

1. An elevator system comprising:an elevator car within an elevator shaft;
a counterweight within the elevator shaft and operably connected to the elevator car;
an indicator element located in a pit of the elevator shaft; and
an inspection system comprising:
a detector located on the elevator car and arranged to detect a location of the counterweight in an inspection region within the pit based a relative position between the counterweight and the indicator element; and
a movable frame having a marker that is movable in response to interaction with the counterweight, the marker located proximate the indicator element.

US Pat. No. 10,479,647

DEPTH SENSOR BASED SENSING FOR SPECIAL PASSENGER CONVEYANCE LOADING CONDITIONS

Otis Elevator Company, F...

1. A passenger conveyance special loading system, comprising:a depth-sensing sensor for capturing 3D depth map data of an object within a field of view that comprises a passenger conveyance door and a waiting area adjacent to the passenger conveyance door;
a processing module in communication with the depth-sensing sensor to receive the 3D depth map data, the processing module uses the 3D depth map data to calculate passenger data associated with the object to determine a special loading condition; and
a passenger conveyance controller to receive the passenger data from the processing module, wherein the passenger conveyance controller controls a passenger conveyance dispatch control function in response to the special loading condition to assign a passenger conveyance with sufficient free space to accommodate the special loading condition.

US Pat. No. 10,479,646

SOLUTION FOR COMPENSATING AN EFFECT OF TEMPERATURE CHANGE IN A PROXIMITY SENSOR IN A MACHINERY BRAKE OF AN ELEVATOR

KONE CORPORATION, Helsin...

1. A machinery brake of an elevator, the machinery brake comprises:a frame part comprising an electromagnet;
an armature part;
an inductive proximity sensor indirectly mounted to one of the following: the frame part, the armature part; and
a target mounted to another of the following: the frame part, and the armature part;
wherein the machinery brake further comprises, for establishing the indirect mounting:
a temperature change compensation device mounted between the inductive proximity sensor and the one of the following: the frame part, and the armature part.

US Pat. No. 10,479,645

ELECTROMAGNETIC BRAKE SYSTEM FOR ELEVATOR APPLICATION

Otis Elevator Company, F...

1. A brake system for an elevator car for an E-stop operation after loss of power comprising:a first brake segment operable to apply a first brake torque at a first time;
a second brake segment sequentially operable subsequent to the first brake segment, the second brake segment operable to apply the first brake torque at a second time subsequent to the first time; and
a third brake segment sequentially operable subsequent to the second brake segment, the third brake segment operable to apply the first brake torque at a third time, the third time is about equal to the second time, wherein the first, the second, and the third brake segment are sequentially operated to stop 125% of a rated load of the elevator car, each of the multiple of sequentially operated brake segments includes an electromagnetic coil that controls the timing and the rate of brake torque for that brake segment, the first brake segment includes a first electromagnetic coil with a characteristic different than a second electromagnetic coil of the second brake segment and a third electromagnetic coil of the third brake segment.

US Pat. No. 10,479,644

ELEVATOR SYSTEM AND METHOD WITH ELEVATOR LINK HAVING INTEGRATED CONTROL LINES

FORUM US, INC., Houston,...

1. An elevator system for supporting a tubular member, comprising:an elevator;
a first elevator link connected to the elevator for supporting the elevator, comprising:
a shaft having an upper shaft end and a lower shaft end;
an upper eye coupled to the upper shaft end and having an upper eye body defining an upper eye opening;
a lower eye coupled to the lower shaft end and having a lower eye body defining a lower eye opening;
a first upper port and a first lower port disposed on the first elevator link;
a first internal passage extending through at least a portion of the shaft and in communication with the first upper port and the first lower port;
a first control line having an upper line section coupled to and in communication with the first upper port and a lower line section coupled to and in communication with the first lower port, wherein the first internal passage and the first control line form a first fluid flowpath; and
a second elevator link connected to the elevator for supporting the elevator.

US Pat. No. 10,479,639

IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD

FUJI XEROX CO., LTD., Mi...

4. An image processing method comprising:a post-processing device executing a creasing process at a creasing position on a paper and a folding process at a folding position on the paper, the creasing position and the folding position being set such that a distance between a position of a fold crease formed by the creasing process and a position of a fold line formed by the folding process is a meaningful distance;
acquiring a read image by reading, in an unfolded state, a first paper that has been subjected to the creasing process and the folding process which are performed by the post-processing device in accordance with the creasing position and the folding position;
analyzing the read image to detect two streaks corresponding to the fold crease and the fold line from the read image, and specifying a position of one of the two streaks as a fold crease position and a position of the other as a fold line position on a basis of the creasing position and the folding position, and generating correction information based on the two detected streaks and comprises information about at least one of the creasing position and the folding position;
outputting, to the post-processing device, the correction information; and
the post-processing device setting the creasing position and folding position based on the correction information such that the fold crease position and the fold line position which are specified match each other when the post processing device executes the creasing process and the folding process on a second paper.

US Pat. No. 10,479,638

PRINTING SYSTEM

RICOH COMPANY, LIMITED, ...

1. A printing system in which a series of conveyance paths to convey a recording medium are formed across a printer and a post-processing device, the printing system comprising:a detection unit that detects that the post-processing device has entered a predetermined state; and
a paper feeding control unit that limits the number of recording media fed to the conveyance path based on a first number that is the number of recording media conveyable to the post-processing device after the post-processing device enters the predetermined state,
wherein, when the detection unit does not detect that the post-processing device has entered the predetermined state, the paper feeding control unit is configured to
determine if the number of recording media in the conveyance path is equal to or less than the first number,
cause a recording medium to not be fed in response to determination that the number of recording media in the conveyance path is not equal to or less than the first number, and
cause the recording medium to be fed in response to determination that the number of recording media in the conveyance path is equal to or less than the first number, and
wherein the paper feeding control unit is configured to increment a feeding count when causing a recording medium to be fed, decrement the feeding count when a recording medium having been subjected to the post processing by the post-processing device is ejected from the post-processing device, and use the feeding count as the number of recording media in the conveyance path.

US Pat. No. 10,479,634

MACHINE AND METHOD FOR PRODUCING BOBBINS OF STRETCH FILM

AMUT S.P.A., Novara (IT)...

1. A winding machine (10) to wind bobbins (5) of stretch film (6) comprising:a supporting frame (11),
at least one reel holder (12), mounted on said supporting frame (11) and rotatable around its own axis (13),
a plurality of reels (1-4) mounted on said at least one holder (12) and integrally rotatable therewith so that at least one first reel (1) is in at least one operative winding position of a bobbin (5),
at least one contact roll (15a) adapted to cooperate with said at least one first reel (1) in said operative winding position of a bobbin (5), wherein said contact roll (15a) is movable between at least one proximal contacting position in which it contacts the bobbin (5) being wound, in order to facilitate the peripheral winding of the stretch film (6) on said bobbin (5), and at least one distal position from said bobbin (5),
at least one accompanying roll (15b) movable between at least one distal position from the bobbin (5) being wound and at least one proximal contacting position in which it contacts the winding bobbin (5) in order to facilitate the peripheral winding of the stretch film (6) on said bobbin (5) during rotation of said at least one reel holder (12) so that said reel (1) can switch from said operative winding position of the bobbin (5) to an operative unloading position of the bobbin (5),
further comprising means (24) for determining the position of said rolls (15a, 15b) with respect to said bobbin (5) being wound
said contact roll (15a) and said accompanying roll (15b) being respectively coupled with at least one first operating arm (16a) and at least one second operating arm (16b) which are rotatable around respective rotation axes (17a, 17b) parallel to the rotation axis of the bobbin, and further comprising electric actuators (18a, 18b) for rotating said operating arms (16a, 16b).

US Pat. No. 10,479,632

STRETCH FILM DISPENSER WITH LIFTING DEVICE

1. A stretch film dispenser with a lifting device, the stretch film dispenser comprising a first seat and a second seat, the lifting device being disposed between the first seat and the second seat, characterized by:a first operating unit, connected to the first seat, the first operating unit having a first through hole, the first through hole being provided with a first fixing member, the first operating unit further having a first opening, the first opening being in communication with the first through hole, the first opening of the first operating unit being provided with a first control member, the first control member having a first perforation, the first control member having a first limiting hole corresponding in position to the first fixing member;
an accommodating unit, having a first end connected to the first operating unit and a second end connected to the second seat, the accommodating unit having a receiving hole therein for accommodating a telescopic rod, an outer peripheral wall of the telescopic rod being formed with a plurality of spaced first positioning holes corresponding to the first fixing member, the first fixing member passing through the first limiting hole and being engaged in one of the plurality of first positioning holes for positioning the telescopic rod.

US Pat. No. 10,479,630

COMPACT INTERFACE MODULE FOR A PRINTING SYSTEM

1. A sheet transfer device for transferring a sheet from a first sheet processing device to a second sheet processing device, the sheet transfer device comprising:a switch moveable between:
a first position for directing sheets from a first transport path arranged for receiving sheets from the first sheet processing device onto a two-way transport path arranged for reversing a transport direction of the sheet; and
a second position for directing sheets from the two-way transport path onto a second transport path arranged for feeding sheets to the second sheet processing device;
a transport pinch actuatable in two opposing directions for reversing a transport direction of a sheet on the two-way transport path;
when in use, the two-way transport path extends downward in a vertically extending free-hanging chamber wherein the sheet engaged by the transport pinch is allowed to hang freely under the influence of gravity,
wherein:
the transport pinch comprises:
a pair of registering wheels for contacting a first side of the sheet;
a pair of actuators for setting an angular velocity of each registering wheel.

US Pat. No. 10,479,628

SHEET CONVEYING DEVICE AND IMAGE RECORDING APPARATUS PROVIDED WITH THE SAME

Brother Kogyo Kabushiki K...

1. A sheet conveying device comprising:a motor;
a first gear attached to the motor such that the first gear is rotatable together with the motor and coaxially with the motor;
a roller configured to be rotated to convey a sheet, the roller extending in an axial direction;
a second gear attached to the roller such that the second gear is rotatable together with the roller and coaxially with the roller, the second gear being in meshing engagement with the first gear;
a first frame supporting the motor; and
a second frame extending in the axial direction of the roller,
the first frame including a wall having a side surface in confrontation with the second frame in the axial direction of the roller,
wherein the wall of the first frame is disposed downstream of the second frame in a first direction along the axial direction of the roller,
wherein an axis of the roller is located upstream of an axis of the motor in a second direction that is perpendicular to the axial direction of the roller,
wherein the second frame is provided with:
a first abutment portion positioned upstream of the wall of the first frame in the first direction and in abutment with the side surface of the wall; and
a second abutment portion positioned upstream of the wall of the first frame in the first direction and in abutment with the side surface of the wall, the second abutment portion being positioned downstream of the first abutment portion in the second direction, and
wherein an abutment position between the second abutment portion and the side surface of the wall of the first frame is positioned downstream in the first direction of an abutment position between the first abutment portion and the side surface of the wall of the first frame.

US Pat. No. 10,479,627

SHEET STACKING APPARATUS AND IMAGE FORMING APPARATUS

Canon Kabushiki Kaisha, ...

1. A sheet stacking apparatus, comprising:a sheet stacking unit configured to stack a sheet thereon; and
a sheet regulating unit movable with respect to the sheet stacking unit, the sheet regulating unit including:
a main body having a regulating surface which is brought into abutment against an edge of the sheet stacked on the sheet stacking unit to regulate a position of the sheet; and
an operating portion having a pressable pressure surface, moved from a first position to a second position by pressing the pressure surface, and pivotably supported on the main body about a pivoting fulcrum positioned above a middle position of the pressure surface, the main body being regulated from moving with respect to the sheet stacking unit when the operating portion is in the first position, and the main body being allowed to move with respect to the sheet stacking unit when the operating portion is in the second position,
wherein the operating portion moves from the first position to the second position by pressing the pressure surface in a direction away from the edge of the sheet to be regulated by the regulating surface.

US Pat. No. 10,479,626

SHEET FEEDING APPARATUS AND IMAGE FORMING APPARATUS

Canon Kabushiki Kaisha, ...

1. A sheet feeding apparatus comprising:a sheet stacking plate on which sheets are to be stacked;
a cassette main body configured to support the sheet stacking plate;
a regulating device disposed at the cassette main body to be movable in a first direction and movable in a second direction opposite to the first direction, and configured to regulate an end position of the sheets;
a plurality of first engaged portions disposed at the cassette main body in a moving direction in which the regulating device is configured to move; and
a plurality of second engaged portions disposed at the cassette main body in the moving direction of the regulating device, wherein the plurality of second engaged portions are arranged at positions separated from the plurality of first engaged portions with respect to a direction intersecting the moving direction of the regulating device;
wherein the regulating device includes:
a holding member,
a lever disposed rotatably at the holding member and configured to be operated,
an elastic member,
a first engaging portion configured to be urged by the elastic member to engage with the plurality of first engaged portions,
a second engaging portion movable in a vertical direction and configured to engage with the plurality of second engaged portions, and
an urging portion provided at the lever and configured to urge the second engaging portion,
wherein, as seen from an axial direction intersecting the moving direction of the regulating device in a state in which the second engaging portion engages with a second engaged portion, the urging portion is disposed between a first surface of the lever and a second surface of the lever opposite to first surface with respect to the moving direction, and the urging portion is disposed completely above the elastic member, and
wherein a rotational movement of the lever moves the second engaging portion upward by the urging portion in a state in which the first engaging portion engages with the first engaged portion by the elastic member.

US Pat. No. 10,479,624

DOCK HOUSING

1. A dock housing for a loading dock, comprising:a base including top and bottom surfaces and front, back and opposed sidewalls, the front wall having integral fork pockets for interaction with forks on a fork truck for movement of the base into a desired location, the top surface having an opening to receive a dock leveler into such opening, the base including adjustable front plates which contact a ground surface; and
a modular frame mounted onto the base in sections, said sections including a frame-front wall, opposed frame-sidewalls and a frame-top wall, the frame-front wall having a trailer-receiving opening to receive a trailer, the frame-sidewalls including a slotted-base attachment for securement of the base and sidewalls together, the frame-sidewalls being secured to a wall of a building;wherein each of the frame-sidewalls are secured to (a) the base, (b) the frame-front wall, and (c) the frame-top wall, thereby assembling the modular frame and dock housing, the dock housing being movable when unsecured from the wall of a building to allow usage at different locations.

US Pat. No. 10,479,621

CONTAINER SEARCH SYSTEM

1. A container search system comprising:a radiation irradiator configured to emit radiation toward a container to be inspected;
a detector installed opposite the radiation irradiator to detect radiation passed through the container;
a transfer cart configured to load a vehicle, which carries the container, and travel along a search path formed between the radiation irradiator and the detector; and
a circulation orbit allowing the transfer cart to circulate along the search path,
wherein a primary side of a linear induction motor configured to generate a moving magnetic field is formed on one of the transfer cart and the search path, and a secondary-side reaction plate configured to generate a linear driving force by inducing a secondary eddy current due to the moving magnetic field is formed on the other one of the transfer cart and the search path,
wherein the transfer cart includes:
a LIM part provided in a middle of the transfer cart to extend in a longitudinal direction of the transfer cart, and having the primary side of the linear induction motor formed therein;
vehicle wheel seating parts formed to extend from both sides of the LIM part in a transverse direction crossing the longitudinal direction of the LIM part, and the vehicle wheel seating parts are configured to provide an entry region into which wheels of the vehicle carrying the container enter, and having seating grooves in which the wheels of the vehicle are seated; and
side parts extending from the vehicle wheel seating parts in the transverse direction, and
wherein the side part includes:
a plurality of running wheels configured to be run when the LIM part is in a non-driven state;
a running wheel driving part configured to drive the running wheels; and
a control part configured to control driving of the running wheel driving part.

US Pat. No. 10,479,620

DESTACKING DEVICE AND METHOD FOR DESTACKING METAL SHEETS

SOUDRONIC AG, Bergdietik...

2. A destacking device, comprising a stacking magazine that is open on the bottom side and has holding means for a stack of metal sheets, and a pull-off device that is disposed beneath the stacking magazine and has a first suction element which is driven in upward and downward movement, and in a reversal position thereof from the upward movement to the downward movement is positioned within the lower opening of the stacking magazine for gripping the respective lowest sheet of a stack of sheets by way of negative pressure and pulling the gripped sheet from the stack, characterized in that the pull-off device comprises an additional suction element, which is driven in upward and downward movement so as to be leading in movement with respect to the first suction element, and the holding means is implemented exclusively by magnets disposed on at least two opposing sides of the stacking magazine, so that the stack can be held in the stacking magazine strictly magnetically.

US Pat. No. 10,479,619

SEPARATOR SUCTION DEVICE WITH ROTARY ACTUATOR

TOYOTA JIDOSHA KABUSHIKI ...

1. A separator suction device capable of suctioning and conveying a separator stored in a state where a plurality of the separators are stacked, the separator suction device comprising:a first arm that includes a first suction portion capable of suctioning the separator by a negative pressure;
a second arm disposed to form a pair with the first arm, rotating around a shared rotational axis, the second arm including a second suction portion capable of suctioning the separator by a negative pressure; and
a transporting unit that moves the first arm and the second arm to selectively arrange the first arm and the second arm at any one of a follow-up position to follow a warped shape of the separator or a correction position to correct the warpage of the separator
wherein the transporting unit includes a drive unit that moves the first arm and the second arm;
wherein the drive unit includes a rotary actuator that rotates the first arm and the second arm around the shared rotational axis.

US Pat. No. 10,479,618

TANK PRESSURIZATION CONTROL FOR AIR CARTS

CNH Industrial Canada, Lt...

1. A pneumatic distribution system configured to distribute a granular product to an agricultural implement, wherein the pneumatic distribution system comprises:a first pressure sensor configured to be fluidly coupled to a storage tank configured to store the granular product, wherein the first pressure sensor is configured to output a first signal indicative of a first static pressure in the storage tank;
a second pressure sensor configured to be fluidly coupled to a meter housing, wherein the second pressure sensor is configured to output a second signal indicative of a second static pressure in the meter housing;
a valve configured to be fluidly coupled between the storage tank and a primary line, wherein the valve is configured to selectively enable an air stream to flow from the primary line to the storage tank, wherein the valve is fluidly coupled to a secondary line, and the secondary line is fluidly coupled between a first section of the primary line and the storage tank; and
a controller communicatively coupled to the first pressure sensor, to the second pressure sensor, and to the valve, wherein the controller is configured to instruct the valve to enable the air stream to flow from the primary line into the storage tank until the first static pressure is greater than the second static pressure by a threshold amount.

US Pat. No. 10,479,617

SORTING CENTER ARCHITECTURE INCLUDING A LOOPED CONVEYOR

Solystic, (FR)

1. A logistics installation for sorting articles, the installation comprising:a looped conveyor for conveying articles according to a direction of rotation, said looped conveyor comprising injection zones and sorting outlet zones alternately distributed along the conveyor, said injection zones being arranged to inject the articles onto the conveyor and said looped conveyor being arranged to unload the articles into the sorting outlet zones;
P pre-sorting devices, each pre-sorting device is being designed for pre-sorting the articles to be sorted by the looped conveyor into a plurality of injection zones, P being an integer greater than or equal to two; and
conveyor lines for conveying the pre-sorted articles from the pre-sorting devices to the injection zones, the conveyor lines being arranged so that each injection zone is connected to one pre-sorting device only and each pre-sorting device is connected to a plurality of injection zones in a configuration in which each pre-sorting device is connected to one in every P injection zones considered sequentially along the conveyor in a given direction,
said installation further comprising a monitoring and control unit using a sorting plan that associates the outlet zones with the articles, said monitoring and control unit being designed to control, based on the sorting plan, each pre-sorting device in order to sort articles in injection zones, to which said pre-sorting device is connected, so that each article being injected on the conveyor from a given injection zone is unloaded in a sorting outlet zone before going through another injection zone that is connected to said given pre-sorting device in the direction of rotation of the conveyor, and, said monitoring and control unit being further designed to control, based on the sorting plan, the unloading of the articles into a given sorting outlet zone arranged between two injection zones connected to a given pre-sorting device.

US Pat. No. 10,479,615

ITEM INFEED APPARATUS AND METHOD FOR A PALLETIZER SYSTEM

Top Tier, LLC, Clackamas...

1. A method of arranging items in rows on a palletizing system row build conveyer, each item having a leading edge and a trailing edge, the method comprising the steps of:a. delivering a first item to a first conveyer;
b. delivering the first item from the first conveyer to a row build conveyer with the first item in a known row build conveyer position such that the position of the trailing edge of the first item is known and so that the first item is correctly oriented on the row build conveyer;
c. delivering a second item to the first conveyer;
d. delivering the second item from the first conveyer to the row build conveyer in a predetermined position relative to the first item, wherein the position of the second item relative to the first item is determined by the known position of the trailing edge of the first item.

US Pat. No. 10,479,613

TRANSPORT SYSTEM AND TRANSPORT METHOD

MURATA MACHINERY, LTD., ...

7. A transport method executed in a transport system including a track, a plurality of transport vehicles that travel along the track and convey a transported object to at least a station, and a controller configured or programmed to perform communication with and control behavior of respective transport vehicles of the plurality of transport vehicles, the transport method comprising:determining that a grip-load request to acquire the transported object from the station is present;
detecting that a first transport vehicle of the plurality of transport vehicles is able to receive a transport command corresponding to the grip-load request and is closest to the station, and providing to the first transport vehicle a traveling command to travel to a destination point that is a junction closest to the station among a plurality of junctions on an upstream side of the station;
before providing the transport command, detecting that a second transport vehicle of the plurality of transport vehicles is able to receive the transport command and is closest to the station, and providing the traveling command to the second transport vehicle; and
providing the transport command to one of the first transport vehicle and the second transport vehicle that first reaches the destination point.

US Pat. No. 10,479,612

CARTON INDUCTION OPTIMIZATION IN ORDER FULFILLMENT PICKING SYSTEM

Staples, Inc., Framingha...

20. A computer-implemented method comprising:receiving data reflecting a set of cartons associated with a conveying system;
identifying a pick-zone visit for each carton in the set of cartons, an identified pick-zone visit for a carton indicating a pick zone among one or more pick zones in the conveying system at which a given item may be placed in the carton;
identifying a high-load pick zone and one or more low-load pick zones based on the identified pick-zone visits for the set of cartons, the high-load pick zone having a load of picks above a first threshold, and the one or more low-load pick zones having a load of picks below a second threshold;
determining that a first carton of the set of cartons includes a pick-zone visit to the high-load pick zone;
holding the first carton of the set of cartons to a later induction release;
ranking the one or more low-load pick zones based on a quantity of cartons having a pick-zone visit to each of the one or more low-load pick zones; and
identifying a second carton with a first pick-zone visit to a particular low-load pick zone of the one or more low-load pick zones based on the ranking of the one or more low-load pick zones; and
inducting the second carton into the conveying system.

US Pat. No. 10,479,611

VERY HIGH-SPEED LINEAR SORTATION CONVEYOR WITH DYNAMIC RECIRCULATION CAPACITY

INTELLIGRATED HEADQUARTER...

1. A sortation controller of a material handling system, the sortation controller comprising:a processor subsystem in communication with a device interface and a pin guide assembly of a recirculation sortation conveyor, the processor subsystem is configured to:
determine a predicted induction position of an undiverted article on an endless apron of the recirculation sortation conveyor;
determine a capacity of two recirculation conveyors that receive articles from a respective lateral side of the recirculation sortation conveyor;
wherein, in response to determining that at least one of the two recirculation conveyors has available capacity, the processor subsystem is configured to:
select at least one of the two recirculation conveyors, wherein the selected at least one of the two recirculation conveyors has available capacity; and
assign a pre-sort section of the pin guide assembly to position the undiverted article on a selected lateral side of the endless apron corresponding to a selected one of the two recirculation conveyors; and
wherein, in response to determining that neither of two recirculation conveyors has available capacity, the processor subsystem is configured to:
assign a divert section of the pin guide assembly to laterally divert to a divert location on a selected lateral side of the recirculation sortation conveyor, wherein the divert section comprises more than one divert guide path, each respective divert guide path comprising an arcuate portion having a continuously increasing slope without a breakpoint to laterally accelerate the diverted article without an abrupt initial force being applied; and
assign the pre-sort section to position the undiverted article on the selected lateral side having one or more pushers that are configured to flank the undiverted article such that it is diverted by the divert section.

US Pat. No. 10,479,610

ANTI-ROLLOVER THREE-SECTION GUIDE RAIL

1. An anti-rollover three-section guide rail, comprisingan upper rail;
a middle rail;
a fixed rail;
a first roller assembly; and
a second roller assembly, wherein
the middle rail is in rolling fit with the fixed rail through the second roller assembly;
a first rolling slot is concavely formed in the left side wall of the middle rail; and a second rolling slot is concavely formed in the right side wall of the middle rail;
the first roller assembly comprises a first roller frame;
the first roller frame is in an inverted U shape and covers the middle rail;
a first roller is pivoted to the left side of the first roller frame; and the first roller is inserted into and in rolling fit with the first rolling slot;
a second roller is pivoted to the right side of the first roller frame; and the second roller is inserted into and in rolling fit with the second rolling slot;
the center of the first roller is located below the center of the second roller;
the upper rail comprises an inverted U-shaped rail body, and the inverted U-shaped rail body covers the first roller assembly;
the left side of the inverted U-shaped rail body extends inwards to form a first supporting plate, and the first supporting plate carries the first roller and is in rolling fit with the first roller; and the right side of the inverted U-shaped rail body extends inwards to form a second supporting plate, and
the second supporting plate carries the second roller and is in rolling fit with the second roller.

US Pat. No. 10,479,609

CONVEYOR SYSTEM WITH SELECTIVE CARRIAGE VACUUM SUPPLY

KHS USA, INC., Sarasota,...

1. A conveyor system comprising:a track extending along a conveying path;
at least one carriage having a mounting section slidably engaging the track, a vacuum connection being formed in the mounting section;
a driving mechanism for moving the at least one carriage along the conveying path;
a plurality of vacuum valves connected to the track along the conveying path; and
a vacuum source connected to the plurality of vacuum valves to supply vacuum thereto;
wherein the conveyor system is configured to selectively supply vacuum to the vacuum connection of the least one carriage via the plurality of vacuum valves based on a proximity of the at least one carriage thereto;
wherein the track includes opposed first and second track surfaces extending along the conveying path, opposed first and second section sides of the mounting section respectively slidably engaging the first and second track surfaces; and
wherein the vacuum connection includes opposed first and second vacuum inlets, the first and second vacuum inlets being respectively arranged on the first and second mounting section sides.

US Pat. No. 10,479,607

BELT CONTACT SURFACE FOR CONVEYOR SYSTEM

Stephenson Technologies I...

1. A conveyor system, comprising:an endless belt mounted in a longitudinal direction through a service line, the endless belt having an upper transport portion adapted to move a wheeled structure through the service line, and a lower return portion;
a support deck positioned below the upper transport portion of the endless belt to support the endless belt, the support deck having a belt contact surface extending along a top of the support deck and in contact with the upper transport portion of the endless belt, the belt contact surface being constructed from a material that is at least partially thermoplastic;
a belt rinsing system including a rinsing system conduit arrangement connectable to a source of rinsing system liquid, and at least one belt rinsing arrangement, wherein each of the at least one belt rinsing arrangement includes:
a rinsing system dirt pass-through aperture in the support deck, over which the upper transport portion of the endless belt travels during operation; and
at least one rinsing system outlet from the rinsing system conduit arrangement positioned proximate to the rinsing system dirt pass-through aperture and positioned to eject rinsing system liquid onto the endless belt upstream from a downstream edge of the rinsing system dirt pass-through aperture in order to capture at least some of the ejected liquid through the rinsing system dirt pass-through aperture.

US Pat. No. 10,479,602

MODULAR BASE FOR FORMING INSTALLATIONS AND METHOD FOR STORAGE BY MEANS OF STACKING AND MOVEMENT OF CASES

1. Modular base for creating a storage installation for stacking and handling of boxes, comprising:a vertically elongated structural module having along its height a lower ground floor, an intermediate first floor and an upper support level, said lower ground floor and said intermediate first floor are each provided with four rail segments, wherein at least one lifting robot operates on the four rails of said lower ground floor and at least one movement robot, different from said at least one lifting robot, operates on the four rails of said intermediate first floor;
said at least one movement robot is configured to support at least one box, wherein the at least one lifting robot passes unblocked through a center of the at least one movement robot;
said upper support level has two opposing edges provided with support locks, wherein said at least one box has a flap that drives and releases a support lock during vertical movement of said at least one box;
the at least one lifting robot and the at least one movement robot are each provided with a trolley having a running system on each of four sides of said robot, wherein the running systems move upward and downward so that the running systems of two opposing sides are moved upward while the other two opposing running systems remain placed over a corresponding pair of opposing rail segments allowing said at least one lifting robot and said at least one movement robot to move in four directions and a 90° change of direction over said corresponding pair of opposing rail segments;
said structural module being configured to be coupled with other structural modules so that the rail segments of said lower ground floor and said intermediate first floor of a structural module are aligned with the rail segments of said lower ground floor and said intermediate first floor of another structural module so that the at least one lifting robot and the at least one movement robot move in four directions inside the coupled structural modules to move said at least one box only between said intermediate first floor and said upper support level.

US Pat. No. 10,479,601

SORTING SYSTEM AND SORTING METHOD

MURATA MACHINERY, LTD., ...

1. A sorting system for sorting and shipping commodities, the sorting system comprising:a pallet transportation vehicle that travels along a travelling route and is able to diverge and merge along the travelling route;
a case transportation vehicle that is structurally different from the pallet transportation vehicle, travels along the travelling route, and is able to diverge and merge along the travelling route;
racks provided along the travelling route and having a height corresponding to multiple floors;
an arrival area, a shipment area, and a sorting area provided along an outer periphery of the travelling route; and
a controller configured or programmed to control each of the pallet transportation vehicle and the case transportation vehicle to transport the commodities from the arrival area to the sorting area via the racks and transport the commodities from the sorting area to the shipment area; wherein
the travelling route includes rails along which both the pallet transportation vehicle and the case transportation vehicle travel;
the rails are provided in a ceiling space of a building accommodating the sorting system; and
each of the pallet transportation vehicle and the case transportation vehicle includes a carriage that travels along the rails, a mast suspended from the carriage, and an elevation platform that includes a transfer device and is able to be raised and lowered along the mast.

US Pat. No. 10,479,600

PRE-LOADED WASTE BAG SYSTEMS AND METHODS

Dear Future Me, LLC, Chi...

1. A pre-loaded waste bag system including:a set of pre-loaded waste bags including
a first waste bag having first waste bag first drawstrings and first waste bag second drawstrings;
a second waste bag having second waste bag first drawstrings and second waste bag second drawstrings,
wherein said second waste bag is positioned inside said first waste bag; and
a waste bin including:
a first drawstring securing member including a first drawstring engagement structure;
a second drawstring securing member including a second drawstring engagement structure,
wherein said first waste bag first drawstrings and said second waste bag first drawstrings engage with said first drawstring engagement structure,
wherein said first waste bag second drawstrings and said second waste bag second drawstrings engage with said second drawstring engagement structure,
wherein at least one of said first drawstring securing member and said second drawstring securing member includes a plurality of hook-shaped structures,
wherein drawstrings that are engaged with said plurality of hook-shaped structures form a grasping region between said hook-shaped structures.

US Pat. No. 10,479,598

ALL-IN-ONE GIFT PACKAGING SYSTEM

Cruickshank LLC, Austin,...

1. A greeting card comprising:a greeting card portion coupled to a gift storage compartment;
wherein said gift storage compartment comprises a volume and depth for storing an item; wherein said greeting card further comprises a greeting card cover, wherein said greeting card cover is moveably coupled to said greeting card portion to move from an open position wherein said greeting card portion is visible to a closed position adjacent to said greeting card portion wherein said greeting card portion is not visible, and wherein said greeting card cover can move from an open position to a closed position without moving the gift storage compartment; and wherein said greeting card cover is coupled to said greeting card such that the greeting card cover is not coupled directly to said gift storage compartment.

US Pat. No. 10,479,597

TAMPER-PROOF CASE SYSTEMS AND METHODS

CITADEL CASING LTD, Road...

1. A tamper-proof wine crate comprising:four side panels;
a bottom panel;
a top panel; and
a unibody frame having a plurality of living hinges, the living hinges configured such that the unibody frame can be folded from a first configuration into a second configuration, the first configuration being a substantially horizontal configuration, and the second configuration being a rectangular prism configuration, the rectangular prism comprising:
four substantially vertical side faces, each of the vertical side faces having a top edge and a bottom edge, and each of the vertical side faces adapted to receive a respective one of the four side panels to form respective crate sidewalls;
a substantially horizontal bottom face in mechanical communication with each bottom edge of the vertical side faces, the bottom face having a plurality of bottle heel receiving cups disposed toward an interior volume of the crate, and the bottom face adapted to receive the bottom panel; and
a substantially horizontal top face having a first edge in mechanical communication with a first vertical side face's top edge and having a second edge in mechanical communication with a second vertical side face's top edge, the first vertical side face disposed opposite from, and generally parallel to, the second vertical side face, the top face having a plurality of bottle top receiving cups disposed toward the interior volume of the crate, and the top face adapted to receive the top panel.

US Pat. No. 10,479,596

PACKAGING FOR TEXTILE ARTICLES

1. Packaging (10) of textile articles (12) comprising:a plurality of textile articles (12) overlapped in a stacking direction (X), so as to form at least one pile (14);
a flat core (16) arranged substantially perpendicular to the stacking direction (X), wherein the flat core (16) comprises recesses (18) along a pair of sides (160); and
a small band (20) that surrounds the at least one pile (14) of textile articles (12) and the flat core (16),wherein the small band (20) is fixed around the pile (14) so as to keep it together and wherein the small band is received in the recesses (18) of the flat core (16);wherein the packaging (10) is free from the presence of T-end fasteners; andwherein the flat core (16) comprises a hook (162) such that, when the packaging (10) is hung by the hook (162), (a) the flat core (16) extends in a vertical direction and the small band (20) extends in a horizontal direction as it surrounds the at least one pile (14) and the flat core (16), and (b) the feature which prevents the textile articles (12) from falling consists of the small band (20) engaging the recesses (18) and the small band (20) urging, with controlled tension, the textile articles (12) towards and/or into contact with the flat core (16).

US Pat. No. 10,479,595

CONTAINER WITH IMPROVED CLOSING MECHANISM

Philip Morris Products S....

1. A container for consumer goods, the container being at least partially formed from one or more fiber-based laminar blanks, the container comprising:a housing having an opening for accessing the consumer goods; and
a lid connected to the housing and movable relative to the housing between a closed position in which the lid covers the opening and an open position in which the opening is uncovered,
wherein a first surface of the lid is disposed adjacent to a first surface of the housing when the lid is in the closed position, and wherein a microsuction structure is provided on only one of the first surface of the lid or the first surface of the housing, for retaining the lid in the closed position relative to the housing, and wherein the other of the first surface of the lid or the first surface of the housing has a surface smoothness of 1.2 micrometers or less as measured in accordance with ISO 8791-4.

US Pat. No. 10,479,594

SYSTEM AND METHODS FOR PACKAGING CABLES

1. A packaging system, comprising:a container to hold coiled cables;
a retainer to hold the coiled cables within the container, the retainer constructed and arranged to hold the coiled cables within the container in a predetermined orientation with respect to a bottom of the container, wherein the retainer comprises a resilient foam retention strip; and
a retention element support configured to hold the retainer in a predetermined position relative to the bottom of the container, wherein the retention element support includes a plurality of vertical portions configured to matingly join the resilient foam retention strip of the retainer through support openings in the resilient foam retention strip.

US Pat. No. 10,479,591

AUTOMATED TIP JAR PRODUCING A COMPENSATING ACTION

Good Fortune Industries, ...

1. An apparatus for dispensing a coupon upon receiving a tip, said apparatus comprising:a housing having an inlet positioned for receiving said tip and an outlet positioned for dispensing said coupon;
wherein said housing has at least one switch positioned within a recess in said housing, wherein said at least one switch is enabled for testing operation of said apparatus.

US Pat. No. 10,479,589

PHARMACEUTICAL CASSETTE

RXSAFE LLC, Vista, CA (U...

1. A cassette for dispensing pharmaceuticals, the cassette comprising:a base defining an outlet and including a drive member, the drive member configured to be rotated; and
a plurality of plate assemblies supported by the base in a stacked configuration, each plate assembly including
a plate body defining an opening aligned with the outlet, and
a disk defining a plurality of cubbies, each disk being rotatable relative to a corresponding plate body by rotating the drive member of the base to selectively align each cubby with the opening in the corresponding plate body,
wherein the plurality of plate assemblies includes a first plate assembly and a second plate assembly adjacent the first plate assembly, wherein the disk of the first plate assembly is coupled to the drive member,
wherein the first plate assembly is a bottommost plate assembly of the plurality of plate assemblies and the second plate assembly is stacked on top of the first plate assembly, wherein the disk of the first plate assembly selectively engages the disk of the second plate assembly, wherein the disk of the first plate assembly is driven by the drive member to move one of the plurality of cubbies into alignment with the outlet while the disk of the first plate assembly is disengaged from the disk of the second plate assembly, and wherein the disk of the first plate assembly is driven by the drive member to move another of the plurality of cubbies into alignment with the outlet while the disk of the first plate assembly engages the disk of the second plate assembly so the first plate assembly is emptied before the second plate assembly.

US Pat. No. 10,479,588

COMBINATION MEDICINE CONTAINERS AND DISPENSERS

1. A combination medicament container and dispenser comprising:a hollow cylindrical bottle defining a cylindrical interior area, an upper cylindrical portion having an upper end, a lower cylindrical portion having a lower end, a window in the lower cylindrical portion of the hollow cylindrical bottle adjacent the lower end and providing communication between the lower cylindrical portion of the cylindrical interior area of the hollow cylindrical bottle and external to the hollow cylindrical bottle, and a central longitudinal axis extending from the upper end of the upper cylindrical portion to the lower end of the lower cylindrical portion;
a cylindrical partition within the cylindrical interior area of the hollow cylindrical bottle transverse to the central longitudinal axis and dividing the cylindrical interior area into an upper cylindrical interior area and a lower cylindrical interior area, the cylindrical partition having a cutout providing communication between the upper cylindrical interior area and the lower cylindrical interior area of the cylindrical interior area;
a cap configured for reception onto the upper end of the upper cylindrical portion of the hollow cylindrical bottle;
a circular dispensary having a top, a bottom, a circular perimeter, a central axis of rotation, the circular dispensary rotationally disposed in the lower cylindrical interior area of the hollow cylindrical bottle under the cylindrical partition such that the central axis of rotation is co-axial with the central longitudinal axis of the hollow cylindrical bottle so that the circular dispensary rotates about the central longitudinal axis of the hollow cylindrical bottle within the lower cylindrical interior area, a plurality of differently sized medicament compartments each compartment having a medicament inlet at the top of the circular dispensary and a medicament outlet at the circular perimeter of the circular dispensary, and a peripheral edge at the bottom of the circular dispensary that allows user rotation of the dispensary; and
a circular insert received onto the circular dispensary, the circular insert having a plurality of removable segments corresponding in number to the plurality of differently sized medicament compartments of the circular dispensary, each one of the plurality of removable segments of the circular insert aligned over a corresponding differentially sized medicament compartment of the plurality of differently sized medicament compartments of the circular dispensary, wherein removal of a segment allows user selection of a particular medicament compartment of the plurality of differently sized medicament compartments from which to dispense a single medicament from the cylindrical interior area of the hollow cylindrical bottle and out the window of the hollow cylindrical bottle;
whereby rotation of the circular dispensary via the peripheral edge in to a first position aligns the medicament inlet of the user selected particular medicament compartment under the cutout of the cylindrical partition to receive a single medicament from the upper cylindrical interior area, and rotation of the circular dispensary via the peripheral edge into a second position aligns the medicament outlet of the user selected particular medicament compartment with the window in the lower cylindrical portion of the hollow cylindrical bottle to dispense the single medicament.

US Pat. No. 10,479,585

CONTAINER WITH MAGNETIC CAP AND CONTAINER HOLDER

YETI Coolers, LLC, Austi...

1. A container and holder system, comprising:a canister comprising:
an insulated double wall structure comprising:
a first end, configured to support the canister on a surface;
a second end; and
a sidewall, the sidewall having an outer diameter;
an opening in the second end extending through the insulated double wall structure; and
a neck structure encircling the opening and extending in an axial direction;
a lid adapted to seal the opening, the lid comprising:
a threaded sidewall configured to be received into the neck structure;
a carry handle, the carry handle rotatably-coupled to a cylindrical side wall of the lid;
a holder comprising:
a holder sidewall having a top end and a bottom end, the holder sidewall having an inner diameter, wherein the holder sidewall is formed from a plastic or elastomeric material and comprises a plurality of sidewall mounting apertures, and wherein each of the plurality of sidewall mounting apertures contains a compression limiter, wherein the compression limiter is formed from a metallic material;
a holder base extending from the bottom end of the holder sidewall;
a locking tab extending from the holder sidewall, the locking tab containing a locking aperture;
wherein the inner diameter of the holder sidewall is greater than the outer diameter of the sidewall of the insulated double wall structure; and
wherein when the carry handle of the lid is in a downward position, the carry handle forms a vertical opening configured to allow a lock to pass through the vertical opening and the locking aperture to lock the lid to the holder.

US Pat. No. 10,479,582

HEATED UTILITY BAG

Milwaukee Electric Tool C...

1. A utility bag comprising:a plurality of panels defining an interior and an exterior, the interior including a cavity configured to receive an item;
a heater element disposed in the cavity;
a battery pack configured for electrical communication with the heater element for powering the heater element; and
a controller removably coupled in selective electrical communication to the battery pack and removably coupled in selective electrical communication with the heater element, wherein the controller includes a housing shaped and sized to mechanically mate with the battery pack for electrical communication therewith, and wherein the housing includes a jack receptacle therein, the utility bag further comprising a jack electrically coupled to the heater element and configured to be received in the jack receptacle in the housing to define the selective electrical communication between the controller and the heater element.

US Pat. No. 10,479,581

LOCKING PACKAGING CONTAINER

All Packaging Company, A...

1. A packaging apparatus comprising:an outer sleeve, including an open compartment and a closed compartment;
an inner sleeve, wherein the outer sleeve and the inner sleeve include plastic laminate;
a first locking mechanism to lock the inner sleeve inside the outer sleeve responsive to sliding the inner sleeve in the open compartment of the outer sleeve, wherein the first locking mechanism locks the packaging apparatus when a first tab of the first locking mechanism located on the inner sleeve moves from a position substantially parallel to a side panel of the inner sleeve and protrudes through an aperture in an interior wall of the outer sleeve in a position extending perpendicular to the side panel of the inner sleeve into the closed compartment of the outer sleeve, the interior wall of the outer sleeve located between the open compartment and the closed compartment;
a tamper-evident first flap located on an exterior panel of the outer sleeve and configured to enter the closed compartment of the outer sleeve and provide access for a user to press the first tab of the first locking mechanism from the position extending perpendicular to the side of the inner sleeve to a position substantially parallel to the side panel of the inner sleeve to unlock the packaging apparatus and allow the inner sleeve to slide out of the open compartment of the outer sleeve of the packaging apparatus; and
a pull tab for removal of the inner sleeve from inside the outer sleeve.

US Pat. No. 10,479,578

BASKET STYLE CARRIER AND BLANK THEREFOR

WestRock Packaging System...

3. A carrier for packaging one or more articles, the carrier comprising:a plurality of outer walls which define an interior;
an intermediate wall at least partially segregates the interior of the carrier in a first direction; and
a first partition structure divides, at least in part, the interior in a second transverse direction, wherein the first partition structure is struck, at least in part, from at least a first one of the plurality of outer walls so as to define a first window in the at least a first one of the plurality of outer walls at a first end of the carrier,
a second partition structure divides, at least in part, the interior in a second transverse direction, wherein the second partition structure is struck, at least in part, from at least a second one of the plurality of outer walls so as to define a second window in the at least a second one of the plurality of outer walls at the first end of the carrier, and
wherein the first and second partition structures are configured and arranged to be automatically erected in the interior of the carrier in response to unfolding a flat collapsed folded blank when the carrier is erected,
wherein the first partition structure comprises a first partition panel struck from a first one of the plurality of outer walls and a second partition panel hinged to the first partition panel, and
wherein the second partition panel is folded to at least partially segregate the interior of the carrier in the first direction.

US Pat. No. 10,479,577

PRINTED MULTILAYER POLYMERIC FILMS AND METHODS OF MANUFACTURE AND USE THEREOF

Printpack Illinois, Inc.,...

1. A printed multilayer polymeric film, comprising:a flexible polymeric film layer, wherein the flexible polymeric film layer is the outermost layer of the printed multilayer polymeric film;
one or more non-photochromic layers each comprising a non-aqueous, solvent-based ink composition having one or more non-photochromic inks that are at least partially transparent to ultraviolet radiation;
one or more photochromic layers each comprising a water-based ink composition having one or more photochromic inks that undergo a color change upon exposure to ultraviolet radiation;
a resin layer; and
a base substrate,
wherein the resin layer is located between the base substrate and at least one of the one or more photochromic layers and the one or more photochromic layers are between the flexible polymeric film layer and the base substrate, and
wherein at least a portion of the one or more non-photochromic layers are located between the flexible polymeric film layer and at least a portion of the one or more photochromic layers.

US Pat. No. 10,479,576

RECLOSEABLE PACKAGE, RECLOSEABLE PACKAGING METHOD, AND METHOD OF USING RECLOSEABLE PACKAGE

Inteplast Group Corporati...

1. A package for storing perishable goods comprising first and second film sheets having respective interior and exterior surfaces and perimeter edge margins, the first and second sheets being sealed together along the perimeter edge margins such that a portion of the interior surface of the first sheet and a portion of the interior surface of the second sheet define an interior of the package for receiving the perishable goods, the package being selectively openable by forming an opening in at least one of the first and second sheets and at least the first sheet having an inner layer defining the interior surface of the first sheet and comprising a polyethylene and a tack agent, at least some of the tack agent having migrated through the polyethylene to the interior surface of the first sheet along substantially an entirety of the portion of the interior surface of the first sheet defining the interior of the package to provide tackiness to the portion of the interior surface of the first sheet configured to temporarily adhere to the first sheet to the second sheet to reseal the package when the portion of the interior surface of the first sheet is pressed against the portion of interior surface of the second sheet after the package has been opened and the tackiness being configured to limit adhesion between the interior surface of the first sheet and said perishable goods such that the perishable goods in direct contact with the interior surface of the first sheet can be non-destructively separated therefrom and withdrawn from the package when the package is open.

US Pat. No. 10,479,574

REUSABLE CABLE TIE

1. A removable cable tie, comprising:an elongate web having a first end and a second end;
a first tooth and a second tooth projecting bilaterally from the web;
a retaining portion positioned at the first end of the web comprising a first leg and a second leg spaced apart to form a C-shaped pocket configured to receive the web, the first leg having a first web retention protrusion at a distal end and projecting laterally toward the second leg, the second leg having a second web retention protrusion at a distal end and projecting laterally toward the first web retention protrusion; and
a gap between the first and second web retention protrusions forming an opening of the pocket therebetween,
wherein the opening is smaller than the width of the web such that the retention portion is configured to allow sliding movement of the web through the pocket in a first direction, and wherein the first and second teeth are configured to engage the retaining portion and prevent the sliding movement of the web in a second direction opposite the first direction, and
wherein the web has a thickness smaller than the opening of the pocket such that twisting the web allows removal of the web from the pocket in a direction toward the opening.

US Pat. No. 10,479,573

LOOP FORMING FASTENER

Loop Ties LLC, Eugene, O...

1. A loop forming fastener, comprising:(a) an elongate body portion having a first end and an opposite tail portion and an intermediate portion, and having a first side and a second side;
(b) a head connected to the elongate body, the head defining an opening configured to receive said tail portion of the elongate body and thereby form a loop;
(c) a ratchet mechanism including an array of teeth aligned on the elongate body and a pawl associated with the head and the opening, and the ratchet mechanism permitting movement of the body therethrough in a first direction but preventing movement of the body portion in an opposite second direction; and
(d) at least one stopper located on the elongate body, said at least one stopper being spaced apart from the head by a predetermined distance, the stopper being too large to pass through the opening of the head and thereby limiting a distance to which the elongate body can be passed through the head and establishing a predetermined minimum size of the loop, and said at least one stopper being constructed of a material that is sufficiently elastic to be deformed and pulled through the opening of the head without damaging the head and without breaking the elongate body portion.

US Pat. No. 10,479,571

DIFFUSING DEVICE

1. A capsule assembly for diffusing a substance in a liquid within a receptacle, wherein the assembly comprises a capsule and a carriage to which the capsule is releasably connected, wherein:the capsule comprises an expandable element and, in a first state the capsule has a first width and in a second state the capsule has a second width;
wherein the second width of the capsule in the second state is greater than that of the first state;
wherein the capsule is connected to the carriage via a releasable connection mechanism that comprises a threaded section and respective parts of the threaded section are provided on the carriage and the capsule; and
wherein each of the carriage and the capsule are provided with a release protrusion and the release protrusions are arranged such that when the carriage and capsule are rotated relative to one another, the release protrusions abut one another to enable the threaded sections to rotate and disengage.

US Pat. No. 10,479,570

BOTTLE AND CAP ASSEMBLY FOR SELECTIVELY DISPENSING ONE BEVERAGE INTO ANOTHER BEVERAGE

1. A beverage container and cap assembly for selectively dispensing a first beverage or a powder into a second beverage, comprising:a beverage container configured to contain the second beverage; and
a cap assembly coupled to the beverage container, wherein the cap assembly comprises:
a base member coupled to the beverage container and defining a fluid flow channel from the base member into the beverage container;
a reservoir member configured to contain the first beverage or the powder disposed within the base member;
wherein the reservoir member comprises a piercing member disposed therein having a first end that is coupled to a deformable first surface of the reservoir member and a second piercing end that is disposed adjacent to an opposed pierceable second surface of the reservoir member; and
a cap structure disposed partially within the base member that is configured to be selectively depressed, thereby contacting the deformable first surface of the reservoir member and first end of the piercing member and biasing the second piercing end of the piercing member through the opposed pierceable second surface of the reservoir member, thereby allowing the first beverage or the powder to flow from the reservoir member through a portion of the base member and into the second beverage contained within the beverage container;
wherein the base member comprises an internal funnel structure configured to selectively direct the first beverage or the powder flow from the reservoir member through the portion of the base member and into the second beverage contained within the beverage container.

US Pat. No. 10,479,566

CONTAINER APPARATUS

BeeHaven Tribe, Fountain...

1. A container apparatus comprising:a container providing a plurality of upwardly opening compartments radially arranged about the container, each of the compartments being sized and configured for removably receiving an at least one item;
a cover rotatably engagable with the container so as to restrict rotary motion of the container relative to the cover in a single, correct direction, the cover configured for selectively covering and preventing access into at least one of the compartments;
the cover defining an at least one cutout positioned and configured for selectively exposing at least one compartment of the container, thereby allowing access into said at least one compartment; and
the cover providing an at least one hinge positioned and configured for allowing the cover to selectively move between one of a closed position, wherein a first half of the cover is in abutting contact with an opposing second half of the cover, and an open position, wherein the first and second halves of the cover are pivoted away from one another;
whereby, the apparatus is configured for allowing selective rotary motion of the container relative to the cover in the correct direction, thereby positioning each of the compartments under the at least one cutout in a sequential order, while preventing rotary motion of the container in an opposing incorrect direction.

US Pat. No. 10,479,565

WINE BARREL

NORTH COAST CONTAINER, C...

1. A wine container comprising:a drum having a pair of opposing ends, at least one of the opposing ends being uncovered;
an end cover resistant to warping arranged in at least one of the opposing ends, the end cover having an upper surface and further comprising:
a plurality of adjacent slats,
a plurality of grooves formed along the upper surface of the end cover, and
a plurality of rods disposed in the plurality of grooves, at least one rod being disposed in each of the plurality of grooves; and
a locking assembly that secures the end cover to one of the uncovered drum ends.

US Pat. No. 10,479,564

CONTAINER SEALING LID WITH UTENSIL HOLDER

Charm Talent Internationa...

1. A lid for sealing a container, comprising:a lid body including:
an inner face extending in a horizontal manner when the lid is disposed on an upright container; and
an outer face opposite the inner face, the outer face having a pattern layer with a portion of an image of an object;
a sealing mechanism positioned on the inner face of the lid body, and configured to sealingly engage an opening of the container to enable the lid to seal the opening of the container; and
at least one holding lug integral with and extending radially outward from the lid body, wherein:
the lid body and the at least one holding lug are formed from a same material;
the at least one holding lug includes a fully surrounded through hole extending along a direction perpendicular to the extension of the inner face of the lid body;
the through hole has a shape that is matched to a shape of a utensil, such that the at least one holding lug is configured to receive an end of the utensil via the through hole and mount the utensil on the lid via a resiliency of the material of the at least one holding lug and a friction between the utensil and the material of the at least one holding lug; and
the at least one holding lug has a shape and position that, together with the shape of the through hole and the portion of the image of the object of the pattern layer, forms the image.

US Pat. No. 10,479,562

PULL RING SEAL SYSTEM FOR CONTAINERS

Chase Corporation, Westw...

1. A system for storing a liquid, comprising:a container including a body portion defining an internal chamber and at least one opening in communication with the internal chamber; and
an insertable plug including a plug body with two rings attached to the plug body via hinges, each hinge attached to an outside surface of an outer circumference of the plug body at a single point, the insertable plug configured to be inserted into the opening so that a portion of the plug body covers a lip of the opening to restrict access through the opening to the internal chamber,
wherein the hinges can be deformed to raise the two rings away from the plug body.

US Pat. No. 10,479,561

STOPPER

PacPlus Co., Ltd., Osaka...

1. A stopper comprising:a stopper main body having a guiding path extending in an axial direction;
a stopper member having a flow path extending in the axial direction and configured to be inserted in the guiding path of the stopper main body; and
a sealing member to be inserted in the flow path of the stopper member in such a manner as to close the flow path,
wherein the stopper member is provided with, at a position where the sealing member is inserted, a first peripheral wall section fixed at first and second ends in such a manner as to extend in the axial direction and a second peripheral wall section separated from the first peripheral wall section in a circumferential direction and fixed at a first end and open at a second end, the second end extending obliquely radially outward along the axial direction.

US Pat. No. 10,479,558

SHIPPING STATEMENT ENVELOPE

1. A shipping statement envelope, comprising:a folded envelope body including a front panel and a rear panel joined to each other at opposite side edges and a bottom edge, and defining an access opening at an upper edge of said rear panel for access to an interior of said envelope body,
said front panel including a transparent portion,
said front panel including a flap portion which extends upwardly beyond said upper edge of said rear panel and which can be folded around a fold line into partially overlapping relationship with said rear panel for closing said access opening;
a pressure-sensitive adhesive layer on said rear panel, said flap portion of said front panel being adhered to said adhesive layer when said flap portion is folded to close said access opening; and
a release layer applied to said pressure-sensitive adhesive layer, so that after a shipping statement is placed in the interior of said envelope body, said release layer can be removed to expose said pressure-sensitive adhesive layer, and said flap portion folded and adhered to said adhesive layer to close said access opening while leaving exposed an area of the pressure-sensitive adhesive lever between the flap portion and the bottom edge of the folded envelope body, said exposed area of the pressure sensitive adhesive layer thereafter usable to engage an associated package to thereby maintain the shipping statement envelope on an associated package for shipment with the transparent portion exposed for viewing.

US Pat. No. 10,479,557

SERVICABLE DRAW AND RETURN TUBE ASSEMBLY

1. A fuel tank assembly,comprising:
a fuel tank including a side wall having an aperture extending there through;
a flange releasably secured on said fuel tank at said aperture and forming an airtight seal between said flange and said side wall around said aperture; and
a plurality of fuel flow components releasably secured to said flange and extending into said aperture of said fuel tank;
wherein said flange includes a flange aperture extending there through, said flange aperture including a plurality of fastener apertures positioned there around, and wherein one of said plurality of fuel flow components is positioned within said flange aperture and extending through said aperture of said fuel tank, said one of said plurality of fuel flow components releasably secured to said flange by fasteners secured within said fastener apertures.

US Pat. No. 10,479,556

INTEGRALLY, EXTRUSION BLOW MOLDED CONTAINER, LABEL AND RFID TAG

Silgan Plastics LLC, Che...

1. A combination of a mold and plastic container comprising:at least two mold portions engaged to form an interior surface having a temperature of at least 420° F.;
a label and an electrical signal generator, the generator being fabricated from materials to retain its signal generating functionality after being heated over 420° F., the generator being fabricated to be compliable with the interior surface of the mold and the generator having first and second sides coated with a heat activated adhesive, the label being located adjacent to the interior surface, and separating the generator from the internal surface; and
a parison having at least an interior layer defining an interior and an exterior layer, the interior being pressurized to expand the parison to force the exterior layer into contact with the generator, label and interior surface to reshape the parison into a plastic container located within the mold portions, the plastic container including a threaded neck portion integrally molded with a vessel portion.

US Pat. No. 10,479,555

DEVICE FOR ADJUSTING THE CAPACITY OF A BEVERAGE CUP

Jae-su Lee, Seoul (KR)

1. A device for adjusting the capacity of a beverage cup, comprising:an insertion unit having at least a volume smaller than an interior volume of a cup and a shape in which a lower end portion of the insertion unit comes in contact with a bottom portion of the cup when inserted into the cup, the insertion unit comprising a first magnet sealed in a bottom portion of the insertion unit; and
an outer fixed unit configured to be placed under the cup, the outer fixed unit comprising a second magnet sealed in the upper portion of the outer fixed unit for interacting with the first magnet of the insertion unit and securing the insertion unit to the cup by a magnetic force between the magnets.

US Pat. No. 10,479,554

CONTAINER AND LID

Kraft Foods Group Brands ...

1. A non-circular, removable lid for a container, the lid comprising:a top wall portion having a raised perimeter including contiguous side edge portions and end edge portions;
a skirt portion depending downwardly from the raised perimeter of the top wall portion and having a free edge, opposite the raised perimeter, with corresponding side edge portions and end edge portions;
two or more raised ribs of the top wall portion extending along the raised perimeter and being entirely spaced from the raised perimeter, the raised ribs defining a planar label region therebetween and strengthening the top wall portion against deformation under stacking loads; and
four or more spanning braces adjacent a bottom surface of the top wall portion, the spanning braces including transverse wall portions spanning across cavities created by the raised ribs on the bottom surface of the top wall portion, the transverse wall portions preventing the raised ribs from spreading apart as a result of stacking loads being placed on the lid;
wherein inward end portions of the spanning braces are chamfered, the spanning braces configured to deflect downwardly with deflection of the top wall portion under a stacking load such that the chamfered end portions minimize contact of the spanning braces with any material spanning beneath the lid.

US Pat. No. 10,479,553

NESTABLE PALLET

Rehrig Pacific Company, ...

1. A nestable pallet comprising:a deck having an upper support surface, opposed side edges and opposed end edges, the deck including a handle opening having at least one handle wall adjacent the handle opening, a plurality of ribs extending upward from the at least one handle wall; and
a plurality of feet extending downward from the deck to a lowermost surface of the pallet, wherein the feet are hollow and elongated in a direction parallel to the side edges of the deck, wherein the handle wall is in a plane between a plane of the lowermost surface of the pallet and a plane of the upper support surface, the deck including openings therethrough that lead into the feet for receiving the feet of an identical nestable pallet nested thereon.

US Pat. No. 10,479,552

PLASTIC CONTAINER WITH LIFT HANDLE FOR FORK TRUCK TRANSPORT

ORBIS Corporation, Ocono...

1. A tote style container comprising:a container body having a base, a first side wall, an opposing second side wall, a first end wall and an opposing second end wall and a plurality of outwardly extending ribs on the first end wall and the second end wall;
a first handle having an upper portion, a first arm and a second arm, the first arm and the second arm of the first handle securely mounted to a top portion of the first end wall, wherein each of the first arm and the second arm of the first handle is in a channel formed in the plurality of outwardly extending ribs, and forming a first opening between the top portion of the first end wall and the upper portion of the first handle, wherein the upper portion of the first handle is spaced above a top edge of the first side wall, a top edge of the second side wall, a top edge of the first end wall and a top edge of the second end wall;
a second handle having an upper portion, a first arm and a second arm, the first arm and the second arm of the second handle securely mounted to a top portion of the second end wall wherein each of the first arm and the second arm of the second handle is in a channel formed in the plurality of outwardly extending ribs, and forming a second opening between the top portion of the second end wall and the upper portion of the second handle where the second opening is aligned with the first opening, wherein the upper portion of the second handle is spaced above the top edge of the first side wall, the top edge of the second side wall, the top edge of the first end wall and the top edge of the second end wall, and wherein the first handle and the second handle are positioned and sized to receive a tine of a fork truck through the first opening and second opening.

US Pat. No. 10,479,551

END CLOSURE WITH DOUBLE ANTI-MISSILE SCORE

BALL CORPORATION, Broomf...

1. A method of forming a metallic end closure with an anti-missile feature, comprising:providing a blank metallic material;
forming an end closure comprising a peripheral curl, a central panel, and a countersink positioned therebetween;
forming a first score line on said central panel, wherein said first score line substantially defines a tear panel;
providing a tool with at least one shaped feature disposed on a distal end of said tool;
pressing said tool into at least one of said central panel and said tear panel such that said at least one shaped feature contacts said at least one of said central panel and said tear panel at a location proximate said first score line to form a first anti-missile feature positioned proximate a second anti-missile feature in said end closure, wherein said first and second anti-missile features have a shallower depth than said first score line, and wherein said first anti-missile feature and said second anti-missile feature are disposed on said tear panel and oriented substantially parallel to each other; and
interconnecting a pull tab to said central panel of said end closure, wherein a nose of said pull tab is positioned over said tear panel to facilitate opening of said end closure when a downward force is applied to said tear panel with said nose of said pull tab.

US Pat. No. 10,479,550

PACKAGING AND METHOD OF OPENING

1. Packaging for a confectionery product, including a confectionery product packaged within the packaging, the packaging comprising:a first part;
a first flange extending at an angle from the first part;
a second part; and
a second flange extending at an angle from the second part,
wherein the first and second parts substantially conform closely to the shape and contour of an outer surface the confectionery product to be packaged in the packaging such that the confectionery product substantially fills the first and second parts of the packaging;
an opening-propagation line formed in at least a portion of at least one of the parts, the opening-propagation line being arranged to break to form an opening to the confectionery packaging,
wherein the first flange is sealed to the second flange to form a seal between the first part and the second part,
wherein at least a part of the opening-propagation line is separate from the seal, such that the packaging is openable while leaving the seal substantially unaffected,
wherein the opening-propagation line is a weakening in at least a portion of at least one of the parts, and
wherein the part including the opening-propagation line is formed from a first layer and a second layer, and the opening-propagation line is not formed in one of the layers.

US Pat. No. 10,479,549

CARTON WITH DISPENSER

Graphic Packaging Interna...

1. A carton for holding at least one article, the carton comprising:a plurality of panels that extends at least partially around an interior of the carton, the plurality of panels comprising a bottom panel, a front panel foldably connected to the bottom panel, a back panel foldably connected to the bottom panel, and a top panel foldably connected to at least one of the front panel and the back panel;
a plurality of end flaps each respectively foldably connected to a respective panel of the plurality of panels, the plurality of end flaps being for closing an end of the carton;
a dispenser comprising a dispenser panel that is pivotably connected to at least one panel of the plurality of panels, the dispenser panel being at least partially defined by a dispenser tear line and comprising a front portion comprising at least a portion of the front panel and a swing arm foldably connected to the front portion and comprising at least a portion of at least one end flap of the plurality of end flaps, the swing arm comprising an upper edge, the dispenser panel being moveable between a closed position and an open position allowing access to the interior of the carton;
the dispenser comprises locking features comprising a relief catch area defined in the swing arm for engaging the front panel and locking the dispenser panel in the open position, the locking features comprising an opening in the end flap adjacent the swing arm and a stop edge of the swing arm, the opening is defined by a first edge, a second edge, a front wall, and the stop edge of the swing arm, the first edge is the upper edge of the swing arm and extends from the relief catch area to the front wall, the second edge extends from the stop edge to the front wall, and the first edge and the second edge diverge so that the opening has a first width at the front wall that is greater than a second width at the stop edge in the closed position of the dispenser panel,
the relief catch area comprising an indentation in the swing arm extending from the upper edge of the swing arm to the stop edge, the stop edge disposed in the opening in the closed position and the open position of the dispenser panel.

US Pat. No. 10,479,548

PAPER INNER CONTAINER FOR HOLDING LIQUID REFILL CONTENTS

NIPPON PAPER INDUSTRIES C...

1. A paper inner container for storage of a refilling liquid content, which has a suction port that is formed in an upper surface thereof and allows insertion of a suction tube of a pump configured to pump up a liquid content and to dispense the liquid content to an outside of the paper inner container,the paper inner container being made of a paper material having a thermoplastic resin laminated on both of its surfaces, and comprising:
four body panels, which form a body having a square tubular shape by coupling an edge of one of the four body panels to a vertical direction sealing panel; and
a pair of upper-surface forming panels and a pair of side panels, which are continuously provided on upper edges of the four body panels to form the upper surface of the paper inner container,
wherein the pair of upper-surface forming panels face each other and overlap in a vertical direction of the paper inner container,
wherein the pair of side panels are positioned between the pair of upper-surface forming panels to face each other and are folded up outwardly from the pair of upper-surface forming panels while also overlapping the pair of upper-surface forming panels,
wherein the pair of upper-surface forming panels have holes, which are formed at centers of the pair of upper-surface forming panels to serve as the suction port,
wherein one of the holes, which is formed in at least a lower upper-surface forming panel of the pair of upper-surface forming panels, is sealed by a tearable film, and
wherein a periphery of the lower upper-surface forming panel of the pair of upper-surface forming panels, an upper upper-surface forming panel of the pair of upper-surface forming panels, and the pair of side panels are bonded to each other to seal the paper inner container.

US Pat. No. 10,479,547

PACKING

KYOCERA Document Solution...

1. Packing comprising:a body section having a first opening;
a cover section configured to close the first opening; and
a label configured to be adhered so as to span across the cover section and the body section with the first opening closed by the cover section, wherein
at least one of the body section and the cover section has a cut section in an edge section thereof,
the cut section is located at a position where the label is adhered so as to be entirely covered with the label,
the cut section has:
a first cut element being a cut substantially in a shape of a letter U opening toward a central section of the body section or a central section of the cover section;
a first part surrounded by the first cut element;
a second cut element being a cut substantially in a shape of a letter U opening toward an edge of the body section or an edge of the cover section; and
a second part surrounded by the second cut element,
the second cut element is located closer toward the central section of the body section or the central section of the cover section than the first cut element,
the second cut element is located opposite to the first cut element,
the first cut element or the second cut element of the cut section is broken so as to peel off from a surface of the body section or a surface of the cover section when the label is removed,
the cover section has a front plate cover section and a rear plate cover section,
the front plate cover section has a second opening,
the rear plate cover section has an engagement section protruding from an edge of the rear plate cover section,
the engagement section has a distal section protruding outward, and
for assembling the cover section,
the distal section of the engagement section is folded,
the engagement section is inserted through the second opening, and
the distal section of the engagement section unfolds inside the front plate cover section.

US Pat. No. 10,479,546

FLUID HOUSING OF A FLUID TREATMENT SYSTEM AND FLUID TREATMENT SYSTEM

1. A fluid treatment system of a fluid system comprisingat least one fluid housing, wherein the at least one fluid housing comprises:
at least one housing part of plastic material,
wherein the at least one housing part comprises:
at least one receiving chamber configured to accommodate at least one fluid treatment component for treating a fluid;
at least one installation opening, closable by a closure housing part, enabling installation of the at least one fluid treatment component in the at least one receiving chamber;
at least one housing fastening section forming a connecting flange protruding radially outwardly from an outer side of the at least one housing part and configured to fasten the fluid housing to a holding component of the fluid system;
at least one housing connecting section surrounding the installation opening and configured to connect the at least one housing part to the closure housing part;
at least one insert comprising metal and/or a composite material, the at least one insert at least partially embedded into the plastic material of the at least one housing connecting section of the at least one housing part, wherein the at least one insert comprises:
at least one annular reinforcement region of the at least one insert is embedded into the plastic material of the at least one housing connecting section such the plastic material is arranged on both radially outer and radially inner sides of the annular reinforcement region of the at least one insert; and
wherein the at least one insert comprises at least one fastening leg connected at a first end to the at least one annular reinforcement region of the at least one insert, the at least one fastening leg embedded, at least in sections, into plastic material of the connecting flange of the at least one housing fastening section.

US Pat. No. 10,479,542

BOTTLE WITH OFFSET SPOUT AND COUNTER-BALANCED BASE

1. A bottle, comprising:a first side and a second side, the second side spaced from and parallel to the first side, each of the first and second sides being generally circular in shape;
a base having a toe portion and a heel portion spaced from the toe portion;
an edge connecting the first side and the second side, the edge extending from the toe portion to the heel portion;
a spout extending from the edge, the spout offset from the vertical centerline of the bottle;
the edge having a curved leading portion extending from the spout to the toe portion, and a curved trailing portion extending from the spout to the heel portion, and wherein the radius of curvature of the trailing portion of the edge is constant from the spout to the heel portion and the radius of curvature of the leading portion of the edge changes between the spout and the toe portion;
wherein, when the bottle is supported on a generally flat horizontal surface by the leading portion of the edge, the bottle will roll to a position resting on the base under the influence of the heel portion.

US Pat. No. 10,479,539

HEAVY DUTY CENTRIFUGAL FEEDER DEVICE AND SYSTEM

1. A heavy duty centrifugal bowl parts feeder system comprised of:a). a feeder bowl system;
b). a support structure contiguous to and beneath the feeder bowl system, the support structure having a top surface;
c). a means for fastening the feeder bowl system to the support structure;
d). an input parts conveyor;
e). an output parts conveyor; and
f). a heavy duty support package for the feeder bowl system comprising:
1) an at least approximately ?? thick inner disc base plate for maximum rigidity;
2) a cone cap made of a durable/high impact material;
3) a plurality of at least three heavy duty casters mounted under the inner disc to support a plurality of the heavy, small parts and to allow for easy maintenance;
4) an aperture/round crack formed by an inset of the inner disc, the aperture/round crack allowing an amount of an oil on the small, heavy parts to disperse into the aperture/crack;
5) a wiper mounted to a bottom of the inner disc which cleans the bottom by pushing the oil into a hole in a base plate and into a collection tray;
6) a variable speed control on the drive of the of the inner disc controlled by a photo eye; and
7) an angle chute with an adjustable discharge angle
wherein the heavy duty centrifugal bowl parts feeder system can feed and orient relatively heavy, small parts the parts being ½ to 5 pounds apiece and one to six inches in diameter.

US Pat. No. 10,479,535

DEPLOYMENT AND AIMING DEVICE

THALES, Courbevoie (FR)

1. A deployment and aiming device of an instrument comprising:a first support,
a second support intended to receive the instrument,
at least one mandrel positioned around the first support, each of the at least one mandrel being rotationally mobile relative to the first support about a mandrel axis (ZN) intersecting said mandrel,
at least one linear element, each of the at least one linear element engaging with at least one of the at least one mandrel, each of the at least one linear element having a first and a second end,
wherein the first end of the at least one linear element is fixed in the at least one mandrel with which it engages at a fixing point, and wherein the second end of the at least one linear element is linked to the second support, such that a rotation of said at least one mandrel about its axis (ZN) generates a displacement of the fixing point,
and wherein each of the at least one mandrel is eccentric about the mandrel axis (ZN) intersecting said at least one mandrel.

US Pat. No. 10,479,534

ROTATABLE STACKED SPACECRAFT

1. A system comprising:at least two spacecraft, including at least a first spacecraft and a second spacecraft, and
an inter-spacecraft coupling arrangement, the at least two spacecraft being mechanically coupled together, in a launch configuration, for launch by a single launch vehicle, by way of the inter-spacecraft coupling arrangement; wherein:
in the launch configuration, the first spacecraft is mechanically coupled with a primary payload adapter of the launch vehicle;
the system is configured to be deployed following injection into a first orbit by the launch vehicle, by separating the first spacecraft from the primary payload adapter while the second spacecraft is mechanically coupled, by way of the inter-spacecraft coupling arrangement, with the first spacecraft;
the first spacecraft includes a thruster configured to execute an orbit transfer maneuver from the first orbit to a second orbit, the thruster delivering thrust along a thrust vector;
each spacecraft includes a respective solar array, each respective solar array having a respective axis of rotation that is substantially orthogonal to the thrust vector;
the inter-spacecraft coupling arrangement, after separating the first spacecraft from the primary payload adapter, is configured, in an on-orbit configuration, to be switchable between a first mode and a second mode, the first mode permitting rotation of the first spacecraft with respect to the second spacecraft about a first axis of rotation that is approximately parallel with the thrust vector, the second mode preventing rotation of the first spacecraft with respect to the second spacecraft about the first axis of rotation; and the first spacecraft is selectively rotatable with respect the second spacecraft such that the respective axis of rotation of the first solar array is at a substantial angle with respect to the respective axis of rotation of the second solar array.

US Pat. No. 10,479,531

SHELL ROTOR ASSEMBLY FOR USE IN A CONTROL MOMENT GYROSCOPE AND METHOD OF MAKING THE SAME

HONEYWELL INTERNATIONAL I...

1. A shell rotor assembly for use in a control moment gyroscope, the shell rotor assembly comprising:a first shell member having a first wall portion and a first rim portion formed integrally in one piece;
a second shell member having a second wall portion and a second rim portion formed integrally in one piece; and
a shaft assembly disposed at an approximate center of the shell rotor assembly and extending between the first shell member and second shell member;
wherein the first rim portion is attached to the second rim portion by an electron beam welding process, whereby a heat-affected area, formed by the electron beam welding process, joins the first rim portion to the second rim portion, the heat-affected area is located over only a portion of lateral surfaces of the first rim portion and the second rim portion wherein the lateral surfaces are configured in a direction which is perpendicular to the shaft assembly wherein the first rim portion includes a first alignment feature and wherein the second rim portion includes a second alignment feature configured to engage the first alignment feature whereby the first shell member and the second shell member are arranged concentrically with one another as a result of engagement between the first alignment feature and the second alignment feature wherein the first alignment feature serves as a backstop to limit the extent of the electron beam welding process.

US Pat. No. 10,479,530

AIRCRAFT HIGH-LIFT DEVICE EQUIPPED WITH AT LEAST ONE DIFFERENTIATED COUPLING SYSTEM

Airbus Operations (S.A.S....

1. An aircraft high-lift device, comprising:a kinematic chain connected to flaps, the kinematic chain comprising a plurality of shafts connected to one another by non-differentiated coupling systems; and
at least one differentiated coupling system that differs from the non-differentiated coupling systems,
wherein the differentiated coupling system is configured to be coupled to an adapter and comprises at least one poka-yoke feature, and
wherein the adapter is configured to connect the differentiated coupling system to an external drive.

US Pat. No. 10,479,524

SEAT SENSOR ARRAY AND CONTROLLER AND SEAT ASSEMBLY INCORPORATING SAME

1. A seat sensor array for use in an aircraft, comprising:a passenger presence sensor located on a first seat, the passenger presence sensor operable for determining if a passenger is present in or absent from a second seat based on a comparison of a measured distance to a passenger receiving portion of the second seat when unoccupied to a measured distance to a passenger present in the second seat when occupied, wherein when a given threshold is exceeded a passenger is deemed present in the second seat;
a seat back position sensor collocated on the first seat with the passenger presence sensor and operable for determining if a seat back of the first seat is in a reclined or upright position; and
a controller in communication with the passenger presence sensor and the seat back position sensor operable for receiving passenger presence information from the passenger presence sensor and seat back position information from the seat back position sensor and communicating this passenger presence information and seat back position information to a crew member device configured to trigger an alarm responsive to a sensed condition by at least one of the passenger presence sensor and the seat back position sensor.

US Pat. No. 10,479,522

INTERNAL RECYCLE REACTOR FOR CATALYTIC INERTING

Hamilton Sundstrand Corpo...

1. An internal recycle reactor for catalytic inerting that is a monolithic body comprising:a motive fluid duct having a motive fluid outlet;
a suction chamber comprising a suction chamber inlet;
a reactant fluid inlet;
a mixing region configured to receive separate gaseous fluids from the motive fluid outlet, the suction chamber inlet, and the reactant fluid inlet to produce a gaseous mixture;
a reactor section comprising a catalyst, wherein the reactor section is configured to receive the gaseous mixture from the mixing region;
an outlet configured to deliver an exhaust gas from the reactor section; and
a recycle passage fluidly connecting the outlet to the suction chamber and configured to deliver a portion of the exhaust gas to the suction chamber though the suction chamber inlet.

US Pat. No. 10,479,521

NONCOMBUSTIBLE GAS DISTRIBUTION METHODS AND SYSTEMS ON AIRCRAFT

THE BOEING COMPANY, Chic...

1. A noncombustible gas distribution method comprising:providing noncombustible gas onboard an aircraft while in flight, the aircraft having left and right main wing tanks on opposite sides of the aircraft and a center wing tank between the left and right main wing tanks;
distributing the noncombustible gas to the center wing tank throughout a continuous, first flight period and, as a result, reducing flammability exposure time in which the center wing tank is flammable during the first flight period or during a subsequent flight period compared to the flammability exposure time that will otherwise occur during the first flight period or during the subsequent flight period without the distribution of the noncombustible gas to the center wing tank throughout the first flight period; and
not distributing noncombustible gas to the left and right main wing tanks while the noncombustible gas is distributed to the center wing tank throughout the first flight period and while the left and right main wing tanks are non-flammable.

US Pat. No. 10,479,520

COMPOSITE STRUCTURE ASSEMBLY HAVING AN INTERCONNECTED LAYERED CORE

The Boeing Company, Chic...

1. A composite structure assembly, comprising:a composite core including a first cell layer having a plurality of first cells and a second cell layer having a plurality of second cells, wherein the first cell layer is adjacent to the second cell layer, and wherein the plurality of first cells are fluidly interconnected with the plurality of second cells; and
a plurality of connecting beams that connect the first cell layer to the second cell layer.

US Pat. No. 10,479,519

NACELLE SHORT INLET FOR FAN BLADE REMOVAL

UNITED TECHNOLOGIES CORPO...

1. A fan assembly for a gas turbine engine, comprising:a fan including a plurality of fan blades, each fan blade extending radially outwardly from a fan hub to a blade tip, the plurality of blade tips defining a fan diameter;
a nacelle surrounding the fan and defining a fan inlet upstream of the fan, relative to an airflow direction into the fan, the nacelle having a forwardmost edge defining an inlet length from the forwardmost edge to a leading edge of a fan blade of the plurality of fan blades, a ratio of inlet length to fan diameter between 0.20 and 0.45; and
a nacelle inner surface defining a nacelle flowpath, the nacelle flowpath having a convex throat portion and a diffusion portion between the throat portion and the leading edge of the fan blade at a topmost portion of the nacelle, the throat portion having a minimum throat radius measured from a fan central axis greater than a blade tip radius measured relative to the fan central axis.

US Pat. No. 10,479,517

COMPOSITE FAN COWL WITH A CORE HAVING TAILORED THICKNESS

The Boeing Company, Chic...

1. A composite fan cowl connected to hold open rods, the composite fan cowl comprising:laminate skins; and
a core, comprising:
a hinge zone having a first thickness;
a body zone having a second thickness different than the first thickness, the body zone different than the hinge zone; and
areas of increased thickness having a third thickness, the third thickness greater than the second thickness, the areas of increased thickness disposed in the body zone of the core, and the areas of increased thickness associated with hold open rods.

US Pat. No. 10,479,516

AIRCRAFT, AIRCRAFT ENGINE, AND AIRCRAFT ENGINE NACELLE

MITSUBISHI AIRCRAFT CORPO...

1. An aircraft, comprising:an engine that includes an engine main body and an engine nacelle, the engine main body outputting thrust force, and the engine nacelle surrounding the engine main body;
an engine pylon that supports the engine main body to an airframe, and axially supports a cowl member to be openable, the cowl member configuring the engine nacelle;
a locking part that locks the cowl member of the engine nacelle in a closed state; and
one or more light emitting sections that are disposed inside the cowl member and show an unlocked state of the cowl member,
wherein the unlocked state of the cowl member becomes visible by light emitted from the one or more light emitting sections and visible from an outside of the engine nacelle through a gap generated on an inner circumference of the cowl member when the cowl member is not locked.

US Pat. No. 10,479,514

ASSEMBLY FOR TURBINE MACHINE WITH OPEN ROTOR CONTRA-ROTATING PROPELLERS, COMPRISING A SMALL DUCT FOR THE PASSAGE OF ANCILLARIES

SAFRAN AIRCRAFT ENGINES, ...

1. An assembly for an aircraft turbine machine comprising a receiver for a pair of open rotor contra-rotating propellers, the assembly comprising a duct, ancillaries routed inside the duct, and an attachment case comprising an annular installation portion on which a first end of the duct is fixed by attachment means, the annular installation portion of the attachment case being arranged around the first end of the duct,wherein the attachment means in an assembled configuration include:
a split ring fitted with internal projections housed inside corresponding orifices formed through said first end of the duct;
a radial loading surface of the split ring made on the annular installation portion of the attachment case, the radial loading surface being tapered and narrowing along a first axial direction of the duct, and being in contact with a complementary tapered peripheral surface of the split ring;
axial loading means of axially loading the split ring along said first direction, said axial loading means being blocked in the axial direction on the annular installation portion of the attachment case.

US Pat. No. 10,479,512

ELECTRICAL DE-ICING FOR AIRCRAFT

Airbus Defence and Space ...

1. A heating element for in-flight de-icing of an aircraft, the heating element comprising:a carbon fiber material for arrangement on a component of an aircraft, the carbon fiber material comprising:
at least two electrical contacts for connecting to an electrical wiring system; and
at least one insulation layer for electrical insulation; and
at least one electrically insulating spacer to rest on the component and/or at least one other structural member of the aircraft after the heating element has been arranged on the component to ensure a spacing between the coated carbon fiber material and the component and/or the at least one structural member.

US Pat. No. 10,479,511

DIRECT CURRENT (DC) DEICING CONTROL SYSTEM, A DC DEICING SYSTEM AND AN AIRCRAFT INCLUDING A DC DEICING SYSTEM

SIKORSKY AIRCRAFT CORPORA...

1. A direct current (DC) deicing control system comprising:a direct current (DC) power source; and
a periodic deicing waveform generator electrically connected to the DC power source, the periodic deicing waveform generator outputting a switched DC voltage having a periodic electrical current waveform including periods of zero voltage and periods of non-zero voltage, the periods of zero voltage defining arc extinguishing events reducing arc formation in the DC deicing control system.

US Pat. No. 10,479,510

MODULAR ENVIRONMENTAL CONTROL CHAMBER

The Boeing Company, Chic...

1. A modular environmental control chamber (MECC) comprising:an outer chamber formed by an outer chamber housing section enclosing an outer face of a section of fuselage, and wherein the outer chamber housing section comprises an air inflow aperture and an air outflow aperture;
an inner chamber formed by an inner chamber housing section enclosing an inner face of the section of fuselage, wherein the inner chamber housing section comprises an air inflow aperture and an air outflow aperture, wherein the section of fuselage separates the outer chamber and the inner chamber, and wherein the outer chamber housing section and the inner chamber housing section are connected to form an outer boundary of the MECC;
an outer chamber airflow delivery and return system comprising i) an outer chamber blower for directing temperature-controlled air to the outer chamber through the air inflow aperture of the outer chamber housing section and ii) an outer chamber air return duct connected to the air outflow aperture of the outer chamber housing section; and
an inner chamber airflow delivery and return system comprising i) an inner chamber blower for directing humidity-controlled air to the inner chamber through the air inflow aperture of the inner chamber housing section and ii) an inner chamber air return duct connected to the air outflow aperture of the inner chamber housing section.

US Pat. No. 10,479,507

AIRPLANE SEAT DEVICE

14. An airplane seat device having at least one backrest, at least one seat component that is coupled to the backrest, and a backrest impact safety device, which, by way of partial decoupling of the backrest from the seat component, is provided for at least partially reducing impact forces on the backrest at least in an event of a crash, whereinthe backrest impact safety device is provided for decoupling the backrest from the seat component prior to the impact forces taking effect,
the backrest impact safety device has at least one inertia module, which is provided for decoupling the backrest impact safety device at least in the event of a crash, and
the backrest impact safety device comprises at least one knuckle joint that has at least one form-fitting element which, in a locked position, is provided for being connected to the inertia module in a form-fitting manner.

US Pat. No. 10,479,503

SUSPENDED LOAD STABILITY SYSTEMS AND METHODS

Vita Inclinata Technologi...

1. A load stability system apparatus for stabilizing a load suspended via a cable from above, the apparatus comprising:a center module comprising:
an attachment point for the cable, configured to allow rotation of the cable relative to the apparatus such that a twist or rotational motion of the cable is decoupled from an orientation of the apparatus and the apparatus in operation is orientable to any direction around an upright axis between the cable and the load;
an attachment point for the load, configured to suspend the load in operation below the load stability system apparatus;
a tensile structural element along the upright axis between the attachment point for the cable and the attachment point for the load,
wherein an upper surface of the tensile structural element is coupled to the attachment point for the cable and a lower surface of the tensile structural element is coupled to the attachment point for the load; and
a thruster mounting structure connected to the tensile structural element, configured to mount an even number of thrusters to the center module in a fixed position,
wherein the fixed position comprises pairs of thrusters arranged on opposite sides of the center module across the upright axis, aligned in parallel and facing a common direction;
a power supply;
a sensor array comprising:
an inertial measurement system;
an orientation measurement system; and
an absolute position measurement system;
a wireless transceiver;
a thruster controller;
two or more thrusters connected to the thruster mounting structure and controlled by the thruster controller; and
a processor operably connected to the sensor array, the wireless transceiver, and the thruster controller;
wherein the processor is configured to:
determine a motion of the load, the motion including any of a pendulum awing, a conical pendulum swing, and a twisting or rotational motion, based on the sensor array measurement systems;
orient the apparatus to a thrust application vector, by controlling thrust provided by the at least one of the thrusters in the pairs of thrusters mounted on opposite sides of the center module, such that the common direction that at least one of the pairs of thrusters faces coincides with the thrust application vector; and
apply thrust along the thrust application vector to autonomously counteract the motion of the load, by controlling at least the pair of thrusters aligned with the thrust application vector.

US Pat. No. 10,479,502

AIRCRAFT PROVIDED WITH A WINCH DEVICE

AIRBUS HELICOPTERS, Mari...

1. An aircraft comprising:a wing extending longitudinally from a streamlined leading edge towards a streamlined trailing edge,
the aircraft being provided with a winch device,
the winch device being provided with a hoist device including a storage drum,
the winch device being provided with a suspension member extending from a first end to a second end that is free and that projects from the hoist device,
the hoist device including a motor member for winding the suspension member around the storage drum and for unwinding the suspension member off the storage drum,
the hoist device being at least partially surrounded by a fairing of the wing,
the hoist device being arranged in an inside volume of the wing in a streamlined position,
wherein the winch device includes a movable arm carried by a hinge,
the hinge giving the movable arm at least one degree of freedom to move in rotation about an axis of rotation relative to the wing,
the hoist device being carried by the movable arm, and
the movable arm and the fairing being movable together between the streamlined position and an extended position.

US Pat. No. 10,479,501

PAYLOAD ORIENTATION CONTROL AND STABILIZATION

1. A balloon payload stabilization system comprising:a balloon envelope; and
a gondola suspended beneath the balloon envelope, the gondola including:
a housing unit coupled to one or more rotational stabilization devices, wherein the one or more rotational stabilization devices are configured to stabilize the gondola around at least a first axis of rotation relative to an orientation of the balloon payload stabilization system; and
a powered gimbal including a payload, wherein the powered gimbal is mechanically coupled to the housing unit and is configured to rotate around one or more axes relative to the orientation of the balloon payload stabilization system to position the payload;
wherein the payload, when positioned in a first position by the powered gimbal, is stably maintained in the first position via rotation around at least the first axis by the one or more rotational stabilization devices.

US Pat. No. 10,479,499

SELF-CONTAINED AERIAL CARGO VEHICLE

The Boeing Company, Chic...

1. An aerial vehicle comprising:one or more rotors configured to propel the aerial vehicle;
a cargo container comprising a first horizontally disposed wall, a second horizontally disposed wall, and a plurality of vertically disposed walls, each of the plurality of vertically disposed walls, the first horizontally disposed wall, and the second horizontally disposed wall are configured to combine to form an enclosure defining a cargo volume, the cargo container configured to move cargo with the aerial vehicle during propulsion by the one or more rotors and configured to contain, at least, the one or more rotors, when the aerial vehicle is not configured for moving cargo,
wherein the first horizontally disposed wall is a ceiling wall of the cargo container and a first surface of the ceiling wall is an exterior top wall of the cargo container, and when the one or more rotors are contained within the cargo container, the first horizontally disposed wall is a floor wall of the cargo container and the first surface of the floor wall is an interior floor wall of the cargo container.

US Pat. No. 10,479,498

SIX DEGREE OF FREEDOM AERIAL VEHICLE

Amazon Technologies, Inc....

1. An aerial vehicle apparatus, comprising:a lifting propulsion mechanism configured to generate a lift sufficient to maintain the aerial vehicle apparatus at an altitude;
a first maneuverability propulsion mechanism;
a second maneuverability propulsion mechanism;
a third maneuverability propulsion mechanism;
a fourth maneuverability propulsion mechanism;
a fifth maneuverability propulsion mechanism;
a sixth maneuverability propulsion mechanism; and
wherein:
the first maneuverability propulsion mechanism, the third maneuverability propulsion mechanism, and the fifth maneuverability propulsion mechanism are aligned in a plane and oriented in a first direction; and
the second maneuverability propulsion mechanism, the fourth maneuverability propulsion mechanism, and the sixth maneuverability propulsion mechanism are aligned in the plane and oriented in a second direction that is approximately perpendicular to the first direction.

US Pat. No. 10,479,497

INBOARD BEARING ASSEMBLIES HAVING LOAD TRANSFER SHOE BOLTS

Bell Textron Inc., Fort ...

1. A proprotor system for a tiltrotor aircraft having a helicopter flight mode and an airplane flight mode, the proprotor system comprising:a yoke having a plurality of blade arms including a first blade arm having an inboard pocket with an outboard surface;
a bearing assembly disposed at least partially within the inboard pocket, the bearing assembly including a shear bearing and a centrifugal force bearing having an integral shoe with an outboard surface;
an inboard beam disposed at least partially between the centrifugal force bearing and the shear bearing; and
a proprotor blade coupled to the inboard beam;
wherein, the integral shoe is coupled to the yoke such that there is a spaced apart relationship between the outboard surface of the integral shoe and the outboard surface of the pocket forming a gap therebetween that prevents centrifugal force load transfer therebetween.

US Pat. No. 10,479,495

AIRCRAFT TAIL WITH CROSS-FLOW FAN SYSTEMS

Bell Helicopter Textron I...

1. An aircraft, comprising:a fuselage having a longitudinal axis extending from a front portion through an aft portion;
a tailboom extending from the aft portion of the fuselage;
first and second horizontal tail members extending from the tailboom;
a first cross-flow fan system rotatably mounted and oriented generally vertically on the first horizontal tail member, the first cross-flow fan system rotates about a first rotation axis, the first cross-flow fan system includes a first rotatable shroud rotatable about the first rotation axis; and
a second cross-flow fan system rotatably mounted and oriented generally vertically on the second horizontal tail member, the second cross-flow fan system rotates about a second rotation axis, the second cross-flow fan system includes a second rotatable shroud rotatable about the second rotation axis;
wherein the first and the second rotation axes are generally parallel.

US Pat. No. 10,479,494

ROTORCRAFT TAIL ROTOR, A ROTORCRAFT FITTED WITH SUCH A TAIL ROTOR, AND A METHOD OF STATICALLY AND/OR DYNAMICALLY BALANCING A ROTORCRAFT TAIL ROTOR

AIRBUS HELICOPTERS, Mari...

1. A rotorcraft tail rotor comprising at least two blade elements, each blade element having a chord and being suitable for pivoting about a collective pitch variation axis Z in order to vary the collective pitch of each blade element of the tail rotor, each blade element including at least one compensation weight comprising a projection extending transverse to the chord of the blade element along a transverse axis Y that is substantially perpendicular to the chord of the blade element, the projection being fixed relative to the blade element;wherein the at least one compensation weight includes a deformable portion that is movable relative to the projection in a plane P that is substantially perpendicular to the transverse axis Y and substantially parallel to the chord of the blade element.

US Pat. No. 10,479,482

PROPELLER WITH PASSIVE VARIABLE PITCH AND ROTATABLE BASE

Kitty Hawk Corporation, ...

1. A propeller assembly comprising:a blade adapted to rotate about a longitudinal axis of the blade to vary a pitch of the blade, wherein the blade includes a plurality of bearings provided on a proximal end of the blade and the plurality of bearings includes a swivel bearing; and
a joint adapted to couple the blade to a central shaft of the assembly via the plurality of bearings, wherein the joint is adapted to telescope and twist along the central shaft of the assembly such that in a first position, the blade is at a first angle and in a second position, the blade is at a second angle greater than the first angle.

US Pat. No. 10,479,478

COMPOSITE MATERIAL SUITABLE FOR A MORPHING SKIN

MBDA UK Limited, Stevena...

1. A morphing skin for an air vehicle structure, the skin comprised of a composite material comprising:a multiplicity of fibers coated with a thermo-sensitive material which is reversibly transitionable in response to a change in temperature, between: (i) an ambient temperature mode in which the thermo-sensitive material will transfer loads in the composite material, and (ii) a heated mode in which an ability of the thermo-sensitive material to transfer loads is reduced, and
a matrix material that incorporates said fibers coated with a thermo-sensitive material, the matrix material remaining stiff when the thermo-sensitive material is heated;
wherein:
the thermo-sensitive material reduces skin stiffness in the heated mode, allowing a change in shape of the skin in the heated mode and maintaining a changed shape of the skin in the ambient mode.

US Pat. No. 10,479,477

ENGAGEMENT MEMBER FOR SPLICING A SPAR ASSEMBLY

Bell Helicopter Textron I...

1. An engagement member for a spar assembly in an aircraft wing comprising:a joining portion having a first attachment surface and a second attachment surface, the first attachment surface is configured to attach to a first C-shaped spar member and the second attachment surface is configured to attach to a second C-shaped spar member; and
a post extending from and integral to the joining portion and disposed between the first attachment surface and the second attachment surface;
wherein the engagement member serves as a post to couple with a rib assembly and to join the first C-shaped spar member and the second C-shaped spar member.

US Pat. No. 10,479,475

COMPOSITE STRINGER BEAM JOINT STRUCTURE OF AN AIRCRAFT

The Boeing Company, Chic...

1. A stringer beam joint structure of an aircraft formed from fiber-reinforced composites comprising:a wing and a wing box, the wing joined to the wing box at a side of a joint structure, the wing and the wing box each including a lower skin; and
a plurality of stringers coupled to the lower skin and all made of fiber-reinforced composites,
wherein:
each stringer has a first end and a second end, where the first and second ends extend in a spanwise direction, and each stringer comprises a cap flange, a base flange, and a web between the cap flange and the base flange;
the cap flange, the base flange, and the web are elongate in each respective stringer's spanwise direction;
the first end of at least one of the plurality of stringers at the side of the joint structure features a web cutout with a taper, formed in the base flange along the respective stringer, the taper located at the first end of each respective stringer, where the taper runs from a knife edge distal end of the base flange to a proximal end that coincides with a full height of the base flange, the taper oriented at an angle between 10 and 15 degrees;
the taper of the base flange is contiguous with an edge of the web cutout;
the base flange comprises an overwrap layer on the taper of the base flange;
the overwrap layer is made of sheet metal or plies of reinforcing fibers that are pre-impregnated with resin; and
the overwrap layer is bonded to the taper of the base flange and configured to constrain an end of the base flange from peeling off a mated skin.

US Pat. No. 10,479,474

FRICTION STIR WELDED WINGTIP TORQUE BOX

The Boeing Company, Chic...

1. A wingtip torque box comprising:an upper monolithic clamshell comprising an upper front spar, an upper rear spar, and an upper skin portion extending between the upper front spar and the upper rear spar;
a lower monolithic clamshell comprising a lower front spar, a lower rear spar, and a lower skin portion extending between the lower front spar and the lower rear spar,
wherein the upper monolithic clamshell and the lower monolithic clamshell form a cavity,
wherein the cavity is a continuous cavity that extends between a wing end and a tip end of the wingtip torque box, providing access through the wingtip torque box between the wing end and the tip end,
wherein the upper front spar is friction stir welded to the lower front spar at a front friction stir welded joint, and
wherein the upper rear spar is friction stir welded to the lower rear spar at a rear friction stir welded joint.

US Pat. No. 10,479,470

ROTARY VANE STEERING GEAR

1. A rotary vane steering gear comprisinga rotary vane hydraulic actuator that has a body divided into a movable part that creates the rotor and a stationary part that creates a stator where both parts together confine the internal hydraulic space in the shape of a toroid with a rotation axis (X-X), and
a rudder stock placed in the rotation axis (X-X), whereinthe body is divided by plane (A-A) that crosses a space perpendicularly to the rotation axis (X-X) and in case of a space of circular toroid shape—by plane (A-A) that crosses the space perpendicularly to the rotation axis (X-X) and a center point of a circle delimiting the space, into the rotor and the stator bound by two thrust rings and that are fastened concentrically on both opposite sides of hydraulic space each to the respective edge of one body part and that overlap the other body part radially, to create in conjunction with the both body parts two concentric slewing bearings that keep the rotor and the stator in one axial and radial position to each other and enable the rotor to rotate in relation to the stator around the rotation axis (X-X).

US Pat. No. 10,479,469

STEERING SYSTEM FOR AN OUTBOARD MOTOR

STEERING SOLUTIONS IP HOL...

1. A steering system for a marine vessel, comprising:a lower unit having a propeller that is drivably connected to a drive shaft that extends through a mid-unit of an outboard motor; and
a gear motor assembly, comprising:
an electric motor that is disposed within the mid-unit,
a drive gear drivably connected to the electric motor, and
a driven gear disposed on a top surface of the lower unit, the lower unit being arranged to pivot the lower unit relative to the mid-unit about the drive shaft to steer a marine vessel, the top surface defining a first protrusion and a second protrusion, the driven gear disposed between the first protrusion and the second protrusion.

US Pat. No. 10,479,466

PADDLING APPARATUS

1. A standing paddleboard paddling training apparatus comprising:a paddle having a blade on at least one end of a paddle shaft;
an attachment removably attachable to the paddle shaft;
an accessory connecting element on a first side of the attachment for removably connecting at least one accessory to the attachment,
wherein an accessory comprises a training aid that comprises:
a base rotatably attached with the accessory connecting element;
an elongated element having a first end and a second end;
wherein the first end of the elongated element is pivotally attached to the base such that the elongated element pivots at least 90 degrees relative to the base such that the elongated element moves between a training configuration and a non-training configuration;
wherein in the training configuration the elongated element's longitudinal axis is perpendicular to the longitudinal axis of the paddle shaft; and,
wherein in the non-training configuration the elongated element's longitudinal axis is not perpendicular such that a terminal end of the elongated element is proximate to the paddle shaft.

US Pat. No. 10,479,465

UNDERWATER MODULAR DEVICE

1. A submersible underwater vehicle, wherein the vehicle comprises:a water tight compartment, wherein the water tight compartment comprises:
1) a cover having a circular shape defining a volume of the water tight compartment, wherein the circular shape is symmetric, and
2) a base coupled to the cover; a circular upper frame coupled to the water tight compartment;
a circular lower frame coupled to the circular upper frame via one or more joints, wherein the circular upper frame, the circular lower frame, and the one or more joints define a hollow portion of the vehicle configured to allow fluid flow there through;
a plurality of actuators coupled to the circular upper frame, the circular lower frame, or the one or more joints, wherein the plurality of actuators are at least in part located radially within at least one of: the circular upper frame or the circular lower frame; and
electronics housed within the water tight compartment, wherein the electronics are configured to effect movement of the plurality of actuators.

US Pat. No. 10,479,463

PERSONAL FLOTATION DEVICE WITH INFLATABLE LIGHT REFLECTIVE BALLOON

12. A personal flotation device comprising:a vest comprising:
a first prong;
a second prong opposite the first prong; and
a connection member connecting the first prong to the second prong, the connection member comprising
a pocket; and
a flap;
an inflatable balloon;
a gas cartridge disposed in the first prong of the vest;
a tube connecting the inflatable balloon to the gas cartridge; and
a harness assembly attached to the vest;
wherein the inflatable balloon is characterized by
a deflated condition in which
the inflatable balloon is deflated;
the inflatable balloon is disposed in the pocket; and
the flap covers an opening of the pocket; and
an inflated condition in which
the inflatable balloon is inflated by the gas cartridge;
a majority portion of the inflatable balloon is out of the pocket; and
the flap is pushed aside by the inflated balloon; and
wherein an outer surface of the inflatable balloon is reflective having a reflectivity larger than 80% under a normal incidence of light having a wavelength in a range from 380 nm to 740 nm.

US Pat. No. 10,479,462

LIFE VEST WITH RESCUE HANDLE

Swimways Corporation, Vi...

1. An apparatus, comprising:a swim assist vest having a back portion; and
a handle assembly including a rescue handle and a base, the handle assembly coupled in a fixed position to the back portion of the swim assist vest such that a weight of a wearer is supported when the rescue handle is pulled,
the back portion of the swim assist vest includes at least a portion formed of an inner layer of fabric, an outer layer of fabric and a flotation panel, at least a portion of the rescue handle being disposed exterior to an outer surface of the back portion of the swim assist vest, the base being disposed such that a portion of an inner surface of the back portion is disposed between the base and the outer surface of the back portion.

US Pat. No. 10,479,459

STABILIZING WATER DIFFUSER SYSTEM FOR WATER SPORTS BOARD, WATER SPORTS BOARD WITH WATER DIFFUSER SYSTEM, AND METHOD OF USING THE SAME

Mink Surf LLC, Waianae, ...

19. A water diffuser for a water sports board comprising:a base, a vertical member, and a front edge;
the base having a front end and back end;
the vertical member extending from the base to a distal end;
the front edge extending from the front end of the base to the distal end of the vertical member;
the front edge comprising a first slope between the front end and the vertical member and a second slope along the vertical member, wherein the second slope is steeper than the first slope so as to define a concave contour,
wherein the water diffuser is configured to modulate a turbulent water flow caused by a fin system.

US Pat. No. 10,479,458

INFLATABLE PADDLE BOARD

Twitch LLC, Steamboat Sp...

1. An inflatable paddle board, comprising:an inflatable stand-up board chamber;
stacked sidewalls to form a rail around at least a portion of a side of the inflatable stand-up board chamber; and
a tent covering between the inflatable stand-up board chamber and the rail.

US Pat. No. 10,479,457

SMALL FLAT-BOTTOMED FLOATING CRAFT, PREFERABLY SWIMMING BOARD CONFIGURED TO OBSERVE UNDERWATER SPACE

AUTEX LTD., Moscow (RU)

1. A swimming board comprising a flat surface which faces a user for providing foot support to a user while the user is standing on the flat surface, characterized in that an information display is mounted in a central zone of the flat surface, wherein the central zone is the zone in which the user maintains balance while the swimming board is in motion, the information display enables the user to maintain balance on the swimming board and view the information display while the swimming board is in motion, the swimming board includes a tilt sensor, the flat surface of the swimming board and the surface of the information display are covered with a transparent insulating layer, said information display is configured to display information from an underwater video recorder or video camera attached to the swimming board in order to survey underwater objects and means for transmitting images from the video camera or video recorder to the information display, wherein information from a tilt sensor provided on the swimming board enables images to be stabilized in a horizontal plane so a user may view the flat surface of the swimming board and simultaneously observe underwater objects without shifting sight.

US Pat. No. 10,479,456

DECK STRUCTURE

1. A marine deck structure kit which can be assembled into one or more sections which are adapted to be interconnected, said sections being comprised of a frame and a deck, said kit being comprised of components for assembly into the frame including a first box-channel which is adapted to form a first side of the frame, a second box-channel which is adapted to form a second side of the frame, a first end plate which is adapted to form a first end of the frame, a second end plate which is adapted to form a second end of the frame, a center support plate, a first steel angle which is adapted for attachment to a first side of the center support plate at a point which is midway between the two ends of the center support plate, a second steel angle which is adapted for attachment to an opposing side of the center support plate at a point which is midway between the two ends of the center support plate, and four self-squaring cross braces, wherein the self-squaring cross braces are adapted for attachment to both the first side and the second side of the frame, wherein the four self-squaring cross braces are adapted to provide support for the center support plate and include (1) a first self-squaring cross brace that is adapted to extend from a first end of the first box-channel to the first steel angle; (2) a second self-squaring cross brace that is adapted to extend from a second end of the first box-channel to the first steel angle; (3) a third self-squaring cross brace that is adapted to extend from a first end of the second box-channel to the second steel angle; and (4) a fourth self-squaring cross brace that is adapted to extend from a second end of the second box-channel to the second steel angle, wherein the first box-channel and the second box-channel include cross-brace mounting brackets which are oriented to align the center support plate in a parallel orientation with respect to the first box-channel and the second box-channel, where the first box-channel and the second box-channel are of equal length; and said kit further being comprised of a multitude of planks which are adapted for attachment to the top side of the frame and which extend from the first side of the frame to the second side of the frame to form the deck.