US Pat. No. 10,456,533

METHODS AND DEVICES FOR PROTECTING CATHETER TIPS AND STEREOTACTIC FIXTURES FOR MICROCATHETERS

Alcyone Lifesciences, Inc...

1. A method of inserting a catheter into a patient, comprising:registering a stereotactic system to the patient;
inserting the catheter having a tip protection device disposed over a distal tip thereof into a working channel of the stereotactic system until a depth stop on the tip protection device prevents further insertion, the tip protection device comprising an elongate body having a central lumen extending longitudinally therethrough configured to slidably receive the catheter, the tip protection device further including a locking mechanism comprising a set screw configured to intersect the central lumen, wherein the locking mechanism of the tip protection device is engaged with a portion of the catheter in the central lumen during insertion to hold the catheter in a fixed longitudinal position with respect to the tip protection device and, thereby, to prevent the catheter from advancing longitudinally any of distally and proximally in the tip protection device;
releasing the locking mechanism of the tip protection and advancing the catheter distally into the patient; and
engaging a locking mechanism of the stereotactic system with the tip protection device by tightening a set screw of the stereotactic system such that the set screw contacts an outer surface of the body of the tip protection device while the catheter is located within the central lumen of the tip protection device, thereby engaging the tip protection device onto the catheter to maintain a fixed longitudinal position between the catheter and the stereotactic system.

US Pat. No. 10,456,532

INJECTION DEVICE

Sanofi-Aventis Deutschlan...

1. An injection device for administering a drug, the injection device comprising:a cartridge holder adapted to receive a drug cartridge;
a hollow injection needle having a proximal tip adapted to pierce a septum of the cartridge so as to establish a fluid communication between the cartridge and the needle; and
a cap arrangeable over the cartridge holder in a manner to cover the needle, wherein, in an initial state, the cartridge is arranged within the cartridge holder with the septum axially spaced from the proximal tip of the needle, wherein the cap is adapted to move the needle relative to the septum for piercing the septum on movement of the cap relative to the cartridge holder,
wherein one or more lateral apertures are arranged in the cartridge holder, and the cap comprises one or more internal longitudinal ribs adapted to protrude through the lateral apertures to frictionally clamp and fix the drug cartridge in an axial position within the cartridge holder, and
wherein movement of the cap in a distal direction takes along the cartridge until the cartridge hits a stop within the cartridge holder, wherein continued motion of the cap in the distal direction overcomes friction between the internal longitudinal ribs and the cartridge allowing complete removal of the cap from the cartridge holder.

US Pat. No. 10,456,531

INJECTION DEVICE

SHL Group AB, Zug (CH)

1. A medicament injection device comprising:a needle shield;
a plunger; and
a tubular rotator, wherein:
said tubular rotator is configured to be rotationally and slidably arrangeable at least partially inside said needle shield of said medicament injection device, and said tubular rotator is configured to slidably and moveably receive said plunger of the medicament injection device inside, so as to enable a relative movement between said tubular rotator, said needle shield, and said plunger,
said tubular rotator comprises a plurality of ridges and a plurality of protrusions on an outer surface of said tubular rotator,
one or more of at least one of the plurality of ridges or at least one of the plurality of protrusions are configured to slide on guide members arranged on an inner surface of the needle shield, so as to cause relative rotation between the tubular rotator and the needle shield, and
said relative rotation causes the plunger to move from a first position in which said tubular rotator restricts movement of the plunger to a second position in which the plunger is allowed to act on a content of said medicament injection device.

US Pat. No. 10,456,530

SUPPLEMENTARY DEVICE FOR ATTACHMENT TO A DRUG INJECTION DEVICE FOR MONITORING INJECTION DOSES HAVING OCR IMAGING SYSTEM WITH GLARE REDUCTION

Sanofi-Aventis Deutschlan...

1. A supplementary device for attachment to an injection device, the supplementary device comprising:an imaging device configured to capture an image of a moveable number sleeve of the injection device;
a plurality of light sources comprising a first group of light sources and a second group of light sources; and
a processor configured to control operation of the imaging device and plurality of light sources and to receive image data from the imaging device,
wherein the processor is configured to:
activate the plurality of light sources sequentially by being configured to activate the first group of light sources followed by the second group of light sources;
capture a first image of the moveable number sleeve when the first group of light sources are activated;
capture a second image of the moveable number sleeve when the second group of light sources are activated;
divide the field of view of the imaging device into a central section and two peripheral sections and to associate the central section with a first illumination condition and the two peripheral sections with a second illumination condition; and
combine the first image of the moveable number sleeve and the second image of the moveable number sleeve into a single image.

US Pat. No. 10,456,529

DRUG INJECTION DEVICE WITH RESETTABLE MECHANISM ALLOWING PISTON ROD RETRACTION UPON DRUG CARTRIDGE CHANGE

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising:a housing;
a dose setting element rotatable relative to the housing during dose setting and dose dispensing;
a drive member coupled to the dose setting element via a clutch;
a piston rod coupled to the housing and to the drive member;
a cartridge holder removably attached to the housing and a reset element, which is permanently rotationally constrained to the housing and rotationally constrained to the drive member during dose setting; and
at least one spring acting on the reset element,
wherein if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing into a position in which the drive member is allowed to rotate relative to the housing, and
wherein the drive member is axially movable relative to the housing between a dose setting position and a dose dispensing position, wherein in the dose setting position, if the cartridge holder is attached to the housing, the drive member is rotationally constrained to the housing via the reset element, and wherein in the dose dispensing position, if the cartridge holder is attached to the housing, the drive member is rotatable relative to the reset element and the housing.

US Pat. No. 10,456,528

DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drive mechanism for a drug delivery device, comprising:a lead screw and a lead screw nut aligned with an axis defining an axial direction and an opposite axial direction,
a screw thread and at least one further screw thread of the lead screw, the screw thread and the further screw thread having the same pitch and being intertwined, and
a drive feature of the lead screw nut,
the drive feature engaging the screw thread and the further screw thread and allowing for, during a dispense operation, a helical movement of the lead screw with respect to the lead screw nut at least in the axial direction, wherein the drive mechanism comprises:
a drive member rotationally locked with the lead screw nut,
the lead screw being coupled with the drive member by a coupling, where the drive member engages the lead screw, the coupling generating a helical movement of the lead screw with respect to the drive member when the drive member is moved in the axial direction with respect to the lead screw, and the coupling being overridden to prevent a helical movement of the lead screw with respect to the drive member when the drive member is moved in the opposite axial direction with respect to the lead screw.

US Pat. No. 10,456,527

GASKET USING MEDICAL SILICONE RUBBER HAVING SLIDABILITY, AND SYRINGE USING SAID GASKET

COKI ENGINEERING INC., O...

1. A gasket, for syringes, to be press-fitted in a syringe barrel and used in a slidable manner, the gasket comprising:a main body portion that is formed of a rigid plastic having a drug solution-resistant property against a drug solution to be loaded in the syringe barrel, and that has a slide-contact surface that slidingly contacts an inner circumferential surface of the syringe barrel; and
a slide-contact ring that is fitted in a concaved groove formed over a whole circumference of the slide-contact surface, and is configured to slidingly contact the inner circumferential surface of the syringe barrel, wherein
within the slide-contact surface, at least a slide-contact surface adjacent to a liquid contact surface with respect to the drug solution is formed to be in contact with the inner circumferential surface and liquid-tight with respect to the inner circumferential surface,
the main body has a liquid-contact side sliding part having the liquid contact surface, the slide-contact surface adjacent to the liquid contact surface, and a back surface contacting the slide-contact ring,
the slide-contact ring is disposed in contact with the back surface of the liquid-contact side sliding part so as to back up the liquid-contact side sliding part,
the slide-contact ring is formed of a slidable silicone rubber obtained by adding a spherical ultrahigh molecular weight polyethylene fine powder to a silicone rubber base material, a filler being added to the silicone rubber base material, wherein a silicone oil is optionally added to the slidable silicone rubber of the slide-contact ring,
when the silicone oil is not added, the slidable silicone rubber contains, in volume ratio, the ultrahigh molecular weight polyethylene fine powder by 44.5 to 60% and the silicone rubber base material containing the filler for a remaining portion, and
when the silicone oil is added, the slidable silicone rubber contains, in volume ratio, the ultrahigh molecular weight polyethylene fine powder by 30 to 65%, the silicone oil by 7 to 40%, a total of the ultrahigh molecular weight polyethylene fine powder and the silicone oil being 37 to 72%, and the silicone rubber base material containing the filler for a remaining portion.

US Pat. No. 10,456,526

MULTI-COMPARTMENT PRE-FILLED MIXING SYRINGES WITH BYPASS

Ethicon, Inc., Somervill...

5. A multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device, comprising:a) a tubular barrel extending along an axis and having a front end and a rear end spaced axially behind the front end wherein the front end has an opening to express the mixture and a removable cap on said opening;
b) a gasket sealing the rear end of the tubular barrel and having an aperture;
c) a plunger located between the gasket and front end that is axially slidable within the tubular barrel that subdivides the tubular barrel into a front compartment between the plunger and the opening and a rear compartment between the plunger and the gasket;
d) a stem attached to the plunger and projecting axially rearward out of the rear end through the gasket, said stem sealing the aperture and axially slidable through the gasket aperture while maintaining the seal, with the dimensions of the aperture closely corresponding to dimensions of the stem; and
e) at least one bypass in the barrel that is positioned between the front end and the rear end of the tubular barrel so as to enable fluid movement of the components between the front compartment and rear compartment;
wherein the plunger and the rear compartment are located axially behind the front compartment,
wherein said front compartment is partially filled with a first component and said rear compartment is at least partially filled with a second component, and
wherein at least one of the components is a fluid;
wherein said device is configured for repeatedly moving the plunger using the stem within the barrel towards the front end and then towards the back end or vice versa,
said device further comprising:
f) a separator slidably positioned on the stem between the plunger and the gasket and subdividing the rear compartment into a rear subcompartment between the gasket and the separator and an intermediate compartment between the separator and the plunger;
g) a rear bypass positioned between the gasket and the separator, wherein the length of the rear bypass is substantially equivalent to the length of the rear subcompartment; and
h) an intermediate bypass positioned between the plunger and the separator, wherein the length of the intermediate bypass is substantially equivalent to the length of the intermediate compartment,
wherein an intermediate bypass gap between the intermediate bypass and the bypass is from about one half to about double the thickness of the separator;
wherein a bypass gap between the intermediate bypass and the rear bypass is from about one half to about triple the thickness of the plunger, said front compartment is partially filled with a first component, said rear subcompartment is partially filled with a second component, and said intermediate compartment is at least partially filled with an intermediate component, and at least one of the components is a fluid.

US Pat. No. 10,456,525

DETENT MECHANISM FOR A MEDICAMENT DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An auto-injector comprisinga syringe carrier adapted to contain at least a majority of a syringe, the syringe carrier having a ramp member with a first ramp and a second ramp, wherein the ramp member defines a longitudinal axis; and
a chassis including a resilient beam having a beam head adapted to engage the ramp member, wherein the carrier is slidably arranged in the chassis,
wherein the first ramp is adapted to deflect the beam head in a radial direction relative to the chassis, when the syringe carrier moves in a first direction relative to the chassis, and the second ramp is adapted to deflect the beam head in a tangential direction relative to the chassis, wherein the radial direction is perpendicular to the longitudinal axis, and wherein the tangential direction is perpendicular to the longitudinal axis and the radial direction
wherein the beam head is configured to be deflected by the first ramp when the syringe carrier moves in the first direction relative to the chassis, and the beam head is configured to be deflected by the second ramp when the syringe carrier moves in a second direction relative to the chassis, wherein the first direction is opposite the second direction.

US Pat. No. 10,456,524

FIELD UPDATE OF AN AMBULATORY INFUSION PUMP SYSTEM

Tandem Diabetes Care, Inc...

1. A method performed by software executable instructions on a hardware processor for remotely updating software on a control device configured to effect operation of an ambulatory infusion pump, comprising:at a central computing system, obtaining data relating to operation of the ambulatory infusion pump;
by the central computing system, verifying compatibility of the control device with a software update including verifying that a device model of the control device is compatible with the software update;
verifying that a user wishes to proceed with the software update;
receiving, at the central computer system, a password required for execution of the software update; and
verifying, by the central computer system, the received password;
transmitting the software update from the central computing system to the control device;
receiving confirmation at the central computing system that the software update has occurred; and
verifying that a safe condition exists for operation of the ambulatory infusion pump by the control device after the software update.

US Pat. No. 10,456,523

MANAGEMENT OF CARE AREA TRANSITIONS OF INTRAVENOUS INFUSIONS

CareFusion 303, Inc., Sa...

1. A method of infusing at least one drug or fluid to a patient comprising:initiating an infusion of at least a first drug and a second drug to a patient by an infusion device, the infusion device comprising at least one programmable processor and memory storing instructions for execution by the at least one programmable processor;
determining, by the infusion device, that the infusion device is to be physically moved from a first care area to a second care area;
comparing the first drug and the second drug to a list of drugs that are allowed to be infused in the second care area;
determining, based on the comparison, that the second drug is not allowed to be used in the second care area; and
stopping the infusion of the second drug while allowing infusion of the first drug;
activating an alarm to notify an end user that the second drug is not transferrable to the second care area.

US Pat. No. 10,456,521

MEDICAMENT DELIVERY DEVICE WITH A CONTROL MECHANISM

SHL MEDICAL AG, Zug (CH)...

1. A control mechanism for a medicament delivery device, which medicament delivery device comprisesa medicament container connection mechanism configured to connect a medicament container with a medicament delivery member;
a penetration and withdrawal mechanism configured to actuate a penetration and a withdrawal sequence;
a medicament delivery drive unit configured to expel a medicament from the medicament container;
an activation mechanism that when activated initiates a penetration and medicament delivery sequence;
a stop mechanism that when activated initiates a withdrawal sequence;
wherein the control mechanism further comprises a control member that is configured to move linearly between a first position and a second position, which control member is connectable to the medicament container connection mechanism, to the penetration and withdrawal mechanism, to the medicament delivery drive unit, to the activation mechanism, and to the stop mechanism
wherein the activation mechanism comprises a manually actuated first locking element and wherein the control member comprises a first seat in which said first locking element is accommodated, such that the control member is connected to the activation mechanism when the control member is in the first position.

US Pat. No. 10,456,520

STRETCHABLE ATTACHMENT APPARATUS

Clinical Biotechnology Re...

1. A hospital bed rail attachment apparatus comprising:a unitary body molded of an elastomeric material and having a smooth and continuous construction, the unitary body comprising an elongated member having a first appendage portion, a second appendage portion, and a central portion extending between the first appendage portion and the second appendage portion;
a first protrusion disposed on the first appendage portion, the first protrusion being substantially rectangular in shape and wider than a width of the central portion;
a first receiving portion being proximally disposed on the first appendage portion in relation to the first protrusion to define a first attachment area extending between the first receiving portion and the first protrusion, the first receiving portion defining an aperture configured to receive the first protrusion;
a second protrusion disposed on the second appendage portion, the second protrusion being substantially rectangular in shape and wider than the width of the central portion; and,
a second receiving portion being proximally disposed on the second appendage portion in relation to the second protrusion to define a second attachment area extending between the second receiving portion and the second protrusion, the second receiving portion defining an aperture configured to receive the second protrusion.

US Pat. No. 10,456,519

APPARATUS AND METHOD FOR IRRIGATING SINUS CAVITY

Acclarent, Inc., Irvine,...

1. A device comprising a catheter having a proximal end and a distal end, wherein at least a portion of the catheter is sized to pass through a nasal cavity and through a sinus ostium to enter a paranasal sinus cavity, the catheter comprising:(i) a dilator disposed at the distal end, wherein the dilator is configured to transition between a non-expanded configuration and an expanded configuration, wherein the dilator is configured to fit the ostium in the non-expanded configuration, and wherein the dilator is configured to dilate the ostium in the expanded configuration,
(ii) an occluding balloon disposed at the distal end, wherein the occluding balloon is configured to transition between a non-expanded configuration and an expanded configuration, wherein the occluding balloon is configured to fit in the ostium in the non-expanded configuration, and wherein the occluding balloon is configured to sealingly engage the ostium in the expanded configuration while the dilator is in the non-expanded configuration,
(iii) a plurality of irrigation ports disposed in a sidewall at the distal end, wherein the occluding balloon is located proximal to the irrigation ports,
(iv) a suction port disposed on a distal face of the distal end, proximate to the irrigation ports, wherein the occluding balloon is located proximal to the suction port, and
(v) a plurality of lumens, the plurality of lumens including:
(i) a first lumen in fluid communication with the dilator,
(ii) a second lumen in fluid communication with the occluding balloon,
(iii) a third lumen in fluid communication with the irrigation ports, and
(iv) a fourth lumen in fluid communication with the suction port,
wherein the first, second, third, and fourth lumens are in fluid isolation relative to each other.

US Pat. No. 10,456,518

ARTERIAL CANNULA WHICH ALLOWS PERFUSION ALONG OPPOSING DIRECTIONS WITHIN A CANNULATED VESSEL

1. A cannula structure configured for cannulating an anatomical vessel of a body of a patient through a vessel entry point and delivering oxygenated blood into the vessel during a veno-arterial extra-corporeal membrane oxygenation (VA ECMO) procedure or a cardiopulmonary bypass procedure, the vessel having a superficial wall and a central axis definable within the vessel, the cannula structure formed as an elongate tubular structure having a length, and comprising:a proximal opening, which is disposed outside of the patient's body and by which oxygenated blood is introduced into the cannula structure for delivery into the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure;
a plurality of fluid outputs, each of the plurality of fluid outputs fluidically coupled along the length of the cannula structure to the proximal opening of the cannula structure, the plurality of fluid outputs comprising:
a distal opening configured for outputting into the vessel a first portion of said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure in a first direction toward the patient's heart; and
a set of fenestrations that is distinct and spaced proximally away from the distal opening, the set of fenestrations configured for outputting into the vessel a second portion of said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure in a second direction counter to the first direction away from the patient's heart, simultaneous with the distal opening outputting the first portion of said oxygenated blood in the first direction during the VA ECMO procedure or cardiopulmonary bypass procedure;
and
a first tube disposed distal to the cannula structure's proximal opening, the first tube having an elongate length along which a plurality of fluidically coupled lumens extend therethrough, the first tube comprising:
a first segment configured to entirely reside within the vessel when the vessel is cannulated, the first segment comprising:
a first lumen having a proximal fluid input fluidically coupled to the proximal opening of the cannula structure and which is configured for receiving said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure;
an elongate projecting portion through which the first lumen extends; and
the cannula structure's plurality of fluid outputs,
wherein the distal opening resides near or at a distal end of the first tube,
wherein the elongate projecting portion extends between the distal opening and the set of fenestrations,
wherein the set of fenestrations resides on a section of the first segment that is (a) proximal to the elongate projecting portion, (b) configured to remain angulated within the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure, and (c) disposed substantially beneath the vessel entry point such that the set of fenestrations outputs the second portion of said oxygenated blood substantially beneath the vessel entry point during the VA ECMO procedure or cardiopulmonary bypass procedure, and
wherein during the VA ECMO procedure or cardiopulmonary bypass procedure, a vector flow component along the central axis of the vessel corresponding to the second portion of said oxygenated blood output by the set of fenestrations is antiparallel to a vector flow component along the central axis of the vessel corresponding to the first portion of said oxygenated blood output by the distal opening;
a second segment proximal to the first segment and configured to essentially entirely reside external to the vessel when the vessel is cannulated, which comprises a second lumen aligned with the first lumen of the first segment, and which between the cannula structure's proximal opening and distal opening is fluidically coupled to each of the cannula structure's proximal opening, the proximal fluid input of the first segment, the first lumen of the first segment, and the cannula structure's plurality of fluid outputs, and which is configured for receiving said oxygenated blood from the cannula structure's proximal opening and delivering said oxygenated blood into the proximal fluid input of the first segment during the VA ECMO procedure or cardiopulmonary bypass procedure; and
an expandable or inflatable cuff which prior to and after expansion or inflation is disposed distal to the second segment and around the first segment at a first segment location proximal to the set of fenestrations, wherein the expandable or inflatable cuff when expanded or inflated has a cross sectional area that is larger than each of a cross sectional area of the vessel entry point and the first segment at the location around the first segment at which the expandable or inflatable cuff is disposed, and wherein the expandable or inflatable cuff comprises:
a sleeve;
a plurality of flange members disposed about the sleeve and configured for expansion away from or contraction toward the first lumen; and
an activation member coupled to the sleeve and configured for selectively expanding or contracting the plurality of flange members,
wherein the expandable or inflatable cuff is configured for allowing blood flow around unflanged portions thereof,
wherein the expandable or inflatable cuff when expanded or inflated is configured to reside entirely within the vessel in a position substantially beneath and immediate to the vessel entry point adjacent to the superficial wall of the vessel, proximal to the set of fenestrations relative to the length of the first tube when the vessel is cannulated and the first tube is in a correct position within the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure.

US Pat. No. 10,456,517

INFUSION SITE FOR IMPROVED MIXING OF FLUIDS

Gambro Lundia AB, Lund (...

1. A method of anticoagulating blood treated during extracorporeal circulation in an extracorporeal circulation blood or plasma treatment device, the extracorporeal circulation blood or plasma treatment device comprising:a filter having a first compartment and a second compartment separated by a semipermeable membrane;
an arterial line in fluid communication with the first compartment of the filter;
a pre-infusion channel for a local anticoagulation substance in fluid communication with the arterial line;
a container of a local anticoagulation substance in fluid communication with the pre-infusion channel;
a venous blood line in fluid communication with the first compartment of the filter, the venous blood line comprising:
a first line portion in fluid communication with an outlet of the filter,
a second line portion in fluid communication with a patient's vascular access,
an infusion site between the first line portion and the second line portion for injecting into the blood line a solution reestablishing blood or plasma ion balance, the infusion site comprising:
a first main channel in fluid communication with the first line portion and having a first passage section,
a second main channel in fluid communication with the second line portion and having a second passage section, and
a turbulence area downstream from and in fluid communication with the first main channel, and upstream from and in fluid communication with the second main channel, the turbulence area comprising a first fluid passage defining a reduction in passage section having a smallest passage section smaller than the first passage section and smaller than the second passage section, and
a secondary channel comprising an inlet for the solution reestablishing blood or plasma ion balance and an outlet in fluid communication with at least one of the first main channel, the turbulence area and the second main channel; and
a container of solution reestablishing blood or plasma ion balance in fluid communication with the secondary channel of the infusion site via a post-infusion line;
the method comprising:
a) flowing blood or plasma through the arterial line,
b) infusing the local anticoagulation substance through the pre-infusion channel into the arterial line,
c) filtering blood through the filter,
d) flowing the filtered blood through the first line portion of the venous blood line,
e) flowing the filtered blood in the turbulence area of the infusion site to cause a turbulence in blood flow,
f) infusing the solution for reestablishing ion balance through the secondary channel of the infusion site, and
g) flowing the filtered blood mixed with the solution for reestablishing blood or plasma ion balance through the second portion of the blood line, wherein step f) is carried out directly before, during or directly after step e).

US Pat. No. 10,456,516

DIALYSIS MACHINE

Quanta Dialysis Technolog...

1. A disposable dialysis cartridge for use in a hemodialysis machine having a dialyser, the cartridge comprising:at least an isolated dialysate flowpath at least partly formed on a surface of the cartridge and configured for delivering a flow of dialysate solution through a dialyser, the dialysate flow path including:
a sterile water inlet which admits sterile water onto the cartridge from a dialysis machine;
a first mixing pump having a pump chamber which receives a predetermined volume of sterile water, and
a dispenser which dispenses into the pump chamber a predetermined volume of a first dialysate solution base,
wherein the first mixing pump is operable to form a homogeneous mixture of sterile water and first dialysate solution base and pump the homogeneous mixture out of the pump chamber.

US Pat. No. 10,456,515

WEARABLE ULTRAFILTRATION DEVICES METHODS AND SYSTEMS

The Trustees of Columbia ...

1. A wearable ultrafiltration apparatus, comprising:a first ultrafilter for filtering a patient's blood along a first fluid path;
a second ultrafilter for filtering the patient's blood along a second fluid path; and
a valve being positionable in a first position for directing the patient's blood along the first fluid path and being positionable in a second position for directing the patient's blood along the second fluid path;
wherein when the valve is in the first position, blood flows along the first fluid path and is prevented from flowing along the second fluid path and when the valve is in the second position, blood flows along the second fluid path and is prevented from flowing along the first fluid path;
wherein when the valve is in the first position, the second ultrafilter is idle and capable of being serviced or replaced, and when the valve is in the second position, the first ultrafilter is idle and capable of being serviced or replaced; and
wherein the valve includes a rod including a handle attached thereto for rotating the rod from the first position to the second position, wherein the rod includes a first edge positioned in a first orientation when the rod is in the first position, the first edge directing the patient's blood to the first ultrafilter along the first fluid path, and wherein when the rod is in the second position the first edge is positioned in a second orientation for directing the patient's blood to the second ultrafilter along the second fluid path.

US Pat. No. 10,456,514

CARDIAC ASSIST DEVICE

University of Leicester, ...

1. A device for providing assistance to ventricular systole of a heart, the device comprising:a pressurizer;
a driver;
wherein the pressurizer is adapted to apply localized pressure to only the external wall of one ventricle or a portion thereof;
wherein the driver is operatively linked to the pressurizer to drive a cycle of increased and decreased pressure applied by the pressurizer; and
wherein the device is braced between the pericardium and the outer wall of a ventricle during use.

US Pat. No. 10,456,513

CARDIAC PUMP WITH SPEED ADAPTED FOR VENTRICLE UNLOADING

TC1 LLC, Pleasanton, CA ...

1. A blood pump, comprising:a chamber including an impeller driven by a motor; and
at least one processor for at least:
determining a time period of a diastolic phase or a time period of a systolic phase of a cardiac cycle of a user; and
varying the speed of the motor, based on the time period of the diastolic phase or the time period of the systolic phase, such that a speed of the motor begins ramping up during the diastolic phase.

US Pat. No. 10,456,512

BABY PRODUCT STERILIZER INCLUDING BREAST PUMP

CIMILRE CO., LTD., Cheon...

1. A baby product sterilizer having a breast pump, the sterilizer comprising:a body having a plurality of ultraviolet lamps located at an inside of the body to sterilize and dry baby products accommodated in the inside of the body;
a cap disposed on a front surface of the body;
a cover located at outer surfaces of the body; and
the breast pump disposed between the body and the cover in such a manner as to be controlled by a controller mounted on the cover.

US Pat. No. 10,456,511

DEVICE FOR USE IN ENDOLUMINAL VACUUM THERAPY

1. A device for applying a negative pressure to an endoluminal surface in the body of a patient to facilitate healing of a wound in the endoluminal surface, comprising:a flexible porous element with a peripheral outer face for contact with the wound, the outer face being defined between opposite proximal and distal ends of the porous element; and
a suction tube for being connected to a suction source externally of the patient's body and which is in fluid communication with the porous element to apply a negative pressure to the wound via the outer face of the porous element upon operation of the suction source in a therapeutically effective amount to facilitate healing of a wound in an endoluminal surface, the porous element having at least one through passageway extending from its proximal end to its distal end for passage of bodily substances of the patient through the porous element separately from any exudate drawn from the wound into the porous element through its said outer face by the applied negative pressure, at least one of the proximal and distal ends of the porous element being otherwise sealed against egress of the bodily substances into the porous element; and
wherein the device is configured for location of the porous element entirely within the body of the patient whereby the distal end of the through passageway faces away from the porous element in a direction into the interior of the body of the patient.

US Pat. No. 10,456,510

ANTI-EXTRAVASATION CATHETER

Cannuflow, Inc., Campbel...

1. An anti-extravasation system comprising:a catheter having a length and outer diameter suitable for extending from a peripheral vein insertion point on a patient to a treatment site, said catheter characterized by an elongated venous section located distal to an interstitial section and comprising:
an inflow lumen;
at least one drainage lumen;
a dissolvable plug disposed within the at least one drainage lumen: and
a plurality of apertures disposed only in the interstitial section of the catheter, said plurality of apertures in fluid communication with the at least one drainage lumen and adapted to drain fluid from tissue surrounding the insertion point when the catheter is operably disposed within the patient;
wherein the venous section of the catheter comprises a uniform outer surface and is structured to prevent fluid communication between the outer surface of the venous section and the at least one drainage lumen; and
a hub proximal to the interstitial section and placed in fluid communication with the inflow lumen and the at least one drainage lumen.

US Pat. No. 10,456,508

DRUG DELIVERY ENDOVASCULAR STENT AND METHOD OF USE

Biosensors International ...

1. A method for making an expandable, metal stent having metal filaments comprising an outer surface region where the outer surface region is coated with a polymer-free limus drug, the stent having a rate of occurrence and/or extent of restenosis or thrombosis resulting from vascular injury in a subject where the rate of occurrence and/or extent of restenosis or thrombosis is reduced relative to that observed by placing at a site of injury, a bare-metal expandable stent formed of interconnected metal filaments or an expandable stent formed of interconnected metal filaments with an outer surface having a coating comprised of a polymer carrier containing a limus drug, the method comprising:roughening regions of the outer surface of the stent filaments to a surface roughness (Ra) of between 20-40 ?in (0.5-1 ?m), and a surface roughness range (Rt) of between 300-700 ?in (7.5-17.5 ?m), and
coating the roughened regions of the stent filaments with a polymer-free limus drug, to a coating thickness greater than the Rt of the roughened stent surface.

US Pat. No. 10,456,506

PRODUCTION OF RESORBABLE POLYMER TUBES MADE OF THREADS

MEKO LASERSTRAHL-MATERIAL...

1. A method for a preparation of a pore-free polymer tube comprising:a. directed winding of at least one polymer filament with a diameter of ?50 ?m to form a polymer tube; and
b. pore-free melting of the at least one polymer filament in the polymer tube at a melting point of the at least one polymer filament or up to a maximal 15° C. above the melting point of the at least one polymer filament under vacuum for 5 seconds to 180 seconds to form the pore-free polymer tube.

US Pat. No. 10,456,504

ACICULAR BODY

TOPPAN PRINTING CO., LTD....

1. An acicular body, comprising:a support plate having a color such that the color has a brightness L* of 5.0 or less as measured in conformity with JIS K5600-4-5 of 1999; and
at least one needle formed on the support plate and including a needle tip portion formed to pierce a skin,
wherein the at least one needle has a total light transmittance of 20% or more such that the at least one needle is transparent or translucent for visible observation of the color of the support plate via the at least one needle, and the support plate is formed such that the needle tip portion of the at least one needle is visually observed against the support plate.

US Pat. No. 10,456,497

PROTECTIVE DRESSING FOR SKIN-PLACED MEDICAL DEVICE

C. R. Bard, Inc., Murray...

17. A dressing for covering a medical device on a skin surface of a patient, comprising:a release layer;
a dressing portion removably attached to the release layer, the dressing portion configured to rest against the skin surface of the patient, the dressing portion defining a hole having an outer perimeter;
a polymeric cover film attached to the dressing portion, the polymeric cover film including a pliable domed portion having a shape corresponding to the outer perimeter of the hole of the dressing portion, the pliable domed portion defining a cavity configured to receive therein the medical device when the dressing is placed on the skin surface of the patient;
a support frame removably attached to the polymeric cover film configured to provide rigidity to the dressing; and
a securement component removably attached to the support frame, the securement component configured to secure a portion of the medical device, wherein the support frame includes a gap configured to enable the securement component to be removed from the support frame and attached to the polymeric cover film without removing the support frame from the polymeric cover film.

US Pat. No. 10,456,495

PACKAGING DEVICE FOR MEDICAL PRODUCTS TO BE STERILIZED OR HAVING BEEN STERILIZED COMPRISING INTERNAL FIXATION

B. Braun Melsungen AG, (...

1. A packaging device comprising:a receiving compartment for medical products to be sterilized or having been sterilized, the receiving compartment sealable in a sterile manner; and
a carrier configured to at least one of hang, guide, or handle the packaging device, the carrier extending into an interior of the receiving compartment and comprising at least one fitting mount for a section of a medical product to be sterilized or having been sterilized,
the carrier comprising an outer guiding section configured to at least one of hang, guide, or handle the packaging device,
the receiving compartment being formed by a film package,
a bonded connection being formed between the carrier and the film package at an interface where the carrier extends into the receiving compartment, and
the outer guiding section projecting through the bonded connection and outside of the film package.

US Pat. No. 10,456,494

STERILIZATION TRAY FOR INSTRUMENTS

Estes Design and Manufact...

1. A system for storing instruments, the system comprising:a tray comprising at least one tray end, wherein at least one slot is formed in the at least one tray end;
an instrument segment fitting within said tray, the instrument segment comprised of a single sheet of a non-corrosive material, the single sheet of a non-corrosive material having a first segment end, an opposing second segment end, and a center segment portion between the first segment end and second segment end, wherein the center segment portion is formed with an undulating profile having a plurality of peaks and troughs and a plurality of segment openings formed therethrough, wherein the segment openings are positioned and formed to receive one or more medical instruments, the instrument segment further comprising a bridge, the bridge comprising a plurality of bridge openings formed therethrough and disposed between adjacent peaks of the instrument segment, thereby spanning a corresponding trough, wherein the bridge openings are positioned and configured to receive the one or more instruments;
a cover constructed and arranged to be positioned on the tray in a manner enclosing said instrument segment within a cavity formed by the cover positioned on the tray, the cover comprising at least one cover end; and
a latch positioned within the at least one cover end, the latch comprising a locking flange constructed and arranged to be received in the at least one slot, wherein the at least one locking flange includes an angled lower edge constructed and arranged to engage the at least one slot when the cover is positioned on the tray.

US Pat. No. 10,456,493

INFECTION CONTROL APPARATUS

Allied Bioscience, Inc., ...

1. An infection control apparatus comprising:an asset tagging unit;
a spraying unit;
a power supply unit;
a DNA/RNA sequencing unit; and
a computing unit comprising a non-transitory computer-readable medium encoded with program instructions for controlling the asset tagging unit, the spraying unit and the DNA/RNA sequencing unit, to perform a method of infection control in a facility.

US Pat. No. 10,456,492

SYSTEMS, METHODS, AND DEVICES FOR OZONE SANITIZATION OF CONTINUOUS POSITIVE AIRWAY PRESSURE DEVICES

SoClean, Inc., Peterboro...

1. A system comprising:an ozone device including an ozone operating system; and
a connector unit fluidly connecting the ozone device to an instrument having a hose and a reservoir, the connector unit comprising a first passageway in fluid communication with the hose and the reservoir, and a second passageway in fluid communication with the ozone operating system and the reservoir, wherein:
the second passageway is at least partially disposed in the first passageway: and
in operation:
ozone gas generated by the ozone operating system flows in a first direction through the second passageway and into the reservoir; and
at least a portion of the ozone gas flows in a second direction from the reservoir, through the first passageway, and into the hose, wherein the first direction is different than the second direction.

US Pat. No. 10,456,491

METHOD OF STERILIZING AN OBJECT WITH ATOMIC NITROGEN FROM A NITROGEN PLASMA

Societe Pour La Conceptio...

1. A method of sterilizing an object with atomic nitrogen from a nitrogen plasma, the method comprising:placing the object in a sterilization chamber; and
sterilizing the object present in the sterilization chamber in a sterilization half-cycle comprising an alternation between stages of injecting atomic nitrogen into the sterilization chamber and of intermediate stages, each intermediate stage including at least one suction stage during which the sterilization chamber is evacuated,wherein each intermediate stage further comprises a stage of injecting molecular nitrogen into the sterilization chamber,wherein the injected atomic nitrogen comes from or is part of a nitrogen plasma generated by a plasma generator from a nitrogen stream, andwherein said nitrogen stream is injected into the sterilization chamber with the plasma generator being switched off during the stage of injecting molecular nitrogen.

US Pat. No. 10,456,490

METHOD OF STERILIZING AN OBJECT WITH ATOMIC NITROGEN FROM A NITROGEN PLASMA

Societe Pour La Conceptio...

1. A method of sterilizing an object with atomic nitrogen from a nitrogen plasma, the method comprising at least:positioning the object in a sterilization chamber;
conditioning the object present in the sterilization chamber, wherein the conditioning includes
a first stage of injecting atomic nitrogen into the sterilization chamber, during which a first concentration of atomic nitrogen in the sterilization chamber is imposed,
a suction stage performed after the first injection stage, during which the sterilization chamber is evacuated,
a stage of injecting molecular nitrogen into the sterilization chamber that is performed after the suction stage, and
a second stage of injecting atomic nitrogen into the sterilization chamber that is performed after the stage of injecting molecular nitrogen, during which a second concentration of atomic nitrogen is imposed in the sterilization chamber; and wherein the injected atomic nitrogen comes from or is part of a nitrogen plasma generated by a plasma generator from a nitrogen stream, and wherein said nitrogen stream is injected into the sterilization chamber with the plasma generator being switched off during the stage of injecting molecular nitrogen, and
sterilizing the object, performed after the conditioning, comprising injecting atomic nitrogen into the sterilization chamber, during which step a concentration of atomic nitrogen in the sterilization chamber is imposed that is greater than the first and second concentrations.

US Pat. No. 10,456,489

DECONTAMINATION COVER FOR DECONTAMINATING AN OBJECT

Diversey, Inc., Fort Mil...

6. A decontamination cover to be applied over an object to be decontaminated, the decontamination cover comprisinga sheet-like body comprising a pliable material, an outward facing surface that is substantially opaque to UVC light and an inward-facing surface that is to be arranged opposite a surface of the object to be decontaminated;
a plurality of UVC sources arranged in an array between the outward-facing surface and the inward-facing surface, wherein the UVC sources emit light through lenses provided to the inward-facing surface;
a plurality of spacers extending from the inward-facing surface, wherein the plurality of spacers are arranged in a second array and distributed over the inward facing surface between the lenses of the UVC sources such that the plurality of spacers maintain a suitable separation between the UVC sources and the surface of the object to be decontaminated to promote complete coverage of the surface with UVC light emitted by UVC sources;
a power supply; and
a controller.

US Pat. No. 10,456,488

ULTRAVIOLET TRANSPARENT STRUCTURE FOR ULTRAVIOLET ILLUMINATION USING SCATTERED AND FOCUSED RADIATION

Sensor Electronic Technol...

1. An apparatus, comprising:an ultraviolet transparent structure having an external surface with exposure to an ambient environment and an internal surface separated from the ambient environment by the external surface;
a set of ultraviolet radiation sources configured to generate ultraviolet radiation through the internal surface of the ultraviolet transparent structure towards the external surface and out to the ambient environment for disinfection of the external surface and/or a targeted item located off of the ultraviolet transparent structure, wherein the set of ultraviolet radiation sources includes a first set of ultraviolet radiation sources configured to generate a scattered type of radiation that uniformly disinfects the external surface of the ultraviolet transparent structure and a second set of ultraviolet radiation sources configured to generate a focused type of radiation that disinfects at least one portion of the targeted item; and
a control system configured to manage the ultraviolet radiation generated from the set of ultraviolet radiation sources, the control system directing the first set of ultraviolet radiation sources to generate the scattered type of radiation towards the external surface of the ultraviolet transparent structure and the second set of ultraviolet radiation sources to generate the focused type of radiation at the targeted item.

US Pat. No. 10,456,487

DEVICE TREATMENT

Sensor Electronic Technol...

1. A system, comprising:an open-ended housing having a cavity formed therein that is configured to receive a device;
at least one ultraviolet radiation source located within the cavity of the housing that is configured to emit ultraviolet radiation towards a surface of the device located within the cavity;
a control unit that determines whether the device needs a cleaning treatment in response to the device being placed within the housing, the control unit determining that the device needs the cleaning treatment in response to determining the surface of the device has an amount of at least one of: bacteria, germs, or viruses, that exceeds a predetermined threshold, the control unit activating operation of the ultraviolet radiation source in response to determining that the device needs the cleaning treatment, wherein the activating includes specifying a plurality of operating parameters for the cleaning treatment of the device, the plurality of operating parameters including a cleaning treatment time that the ultraviolet radiation source emits the ultraviolet radiation towards the surface of the device, a dosage of ultraviolet radiation delivered by the ultraviolet radiation source, a power setting for operating the ultraviolet radiation source, and a maximum operating temperature;
an input component that permits a user to adjust at least one of the plurality of operating parameters; and
an output component that provides status information of the cleaning treatment for use by the user.

US Pat. No. 10,456,486

ULTRAVIOLET DIFFUSIVE ILLUMINATION

Sensor Electronic Technol...

1. An illuminator comprising:a reflective cavity comprising a plurality of surfaces, wherein at least one surface of the plurality of surfaces is formed of a first material configured to reflect at least 70% of ultraviolet radiation, and at least one surface of the plurality of surfaces is formed of a second material configured to transmit at least 30% of the ultraviolet radiation through the second material and out of the reflective cavity and reflect at least 10% of the ultraviolet radiation, wherein the at least one surface formed of the second material includes non-uniform random nano-patterning;
a set of ultraviolet radiation sources, wherein at least one ultraviolet radiation source is located adjacent to a side surface of the reflective cavity and configured to generate ultraviolet radiation; and
at least one parabolic mirror located adjacent to the side surface of the reflective cavity and the at least one ultraviolet radiation source.

US Pat. No. 10,456,485

SINGLE-EMITTER LIGHTING DEVICE THAT OUTPUTS A MINIMUM AMOUNT OF POWER TO PRODUCE INTEGRATED RADIANCE VALUES SUFFICIENT FOR DEACTIVATING PATHOGENS

KENALL MANUFACTURING COMP...

1. A lighting device configured to deactivate MRSA bacteria in an environment, the lighting device comprising:at least one lighting element with a single light source configured to provide light, at least a first component of the light having a wavelength of about 405 nm, and at least a second component of the light having a wavelength of greater than 420 nm,
wherein the first component of light has a minimum integrated irradiance of 0.01 mW/cm2 measured from any unshielded point in the environment that is 1.5 m from any point on any external-most luminous surface of the lighting device.

US Pat. No. 10,456,484

STERILISATION CONTAINER, METHOD OF STERILISATION AND STERILISATION APPARATUS

MERCER TECHNOLOGIES LIMIT...

1. A single-use rigid or semi-rigid single use/disposable container having:a. a base and side walls defining a cavity for receiving an item to be sterilized;
b. a rim extending outwardly from the side walls of the container; and
c. a sealable conduit integrally formed with the base or one of the side walls of the container,
the sealable conduit providing a direct passage through the base or the one of the side walls of the container to the cavity,
the sealable conduit being elongate in cross section at the base or one of the side walls of the container,
the sealable conduit being configured and arranged to allow, when a cover is secured to the rim in use, steam sterilant to be introduced into the container and steam sterilant and condensate to be removed from the container between an exterior of the container and an interior of the container by direct passage through the base or the one of the side walls of the container via the conduit,
wherein the sealable conduit is formed by two opposing side walls that extend outwardly from the base or the one of the side walls of the container with which the sealable conduit is integrally formed,
wherein said container is a single-use container.

US Pat. No. 10,456,482

PSMA—TARGETED NIR DYES AND THEIR USES

On Target Laboratories, L...

1. A compound selected from the group consisting of:

US Pat. No. 10,456,481

DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE TRANSFER IN VIVO

1. A method of treating diabetes in a patient in need thereof, the method comprising administering a therapeutically effective amount of a therapeutic nucleic acid encoding insulin, a glucagon antagonist, GLP-1 or leptin to a target tissue in the patient, wherein said administering comprises contacting said target tissue with a dually derivatized (DD) chitosan nucleic acid polyplex, said DD chitosan nucleic acid polyplex comprising a chitosan-derivative nanoparticle and said therapeutic nucleic acid, wherein said chitosan-derivative nanoparticle comprises chitosan functionalized with arginine (Arg) and a hydrophilic polyol (HP) of Formula VII:
wherein:
R2 is selected from: H and hydroxyl;
R3 is selected from: H and hydroxyl; and
X is selected from: C2-C6 alkylene optionally substituted with one or more hydroxyl substituents;provided said hydrophilic polyol is not gluconic acid.

US Pat. No. 10,456,479

HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF

HANGZHOU DAC BIOTECH CO.,...

14. A ligand-drug conjugate of formula (2):
wherein:
D represents a cytotoxic drug;
L represents a cell-binding ligand;
V represents a polar or charged group selected from the group consisting of
(phosphonates),(phosphoric acids),(phosphoramidic acids),(phosphorodiamidic acids), and(phosphoric triamides), wherein R is H or C1˜C8 alkyl; Q is CH or N L is NH, NH—(CH2)m, or N(CH3)(CH2)m, wherein m is an integer from 1 to 5, and “” is a site of attachment;U? represents a covalent linkage selected from the group consisting of a disulfide linkage, a thioether linkage, a thioester linkage, an amide linkage, an ester linkage, a carbon-nitrogen linkage, a carbon-carbon linkage, a hydrazine linkage, a hydrazide linkage, a hydrazone linkage, an ether linkage, a carbamate linkage, and a carbonate linkage;
W? represents a covalent linkage selected from the group consisting of an amide linkage, a carbamate linkage, a urea linkage, a disulfide linkage, a thioether linkage, a thiocarbamate linkage, a dithiocarbamate linkage, and a thioester linkage;
X represents a component composed of one, two, or three methylene units optionally substituted with an alkyl, halo, hydroxyl, alkoxy group;
Y represents a component composed of one, two, or three methylene units optionally substituted with an alkyl, halo, hydroxyl, or alkoxy group;
n is an integer from 1 to 100, provided that when n>1, values of each V, X, and Y in the repeating brackets of Formula (2) are independent and do not have to be identical.

US Pat. No. 10,456,476

METHOD INVOLVING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF POLY(ETHYLENE GLYCOL)

Nektar Therapeutics, San...

1. A method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer comprising a protected reactive group, the method comprising:(i) providing a water-soluble and non-peptidic polymer comprising a protected reactive group and having a structure, R?-POLY-OH, where POLY is a linear polyethylene glycol having a formula, —OCH2CH2(OCH2CH2)n—, R? is a protected carboxylic acid, and n is an integer selected from about 3 to about 2000, and
(ii) reacting R?-POLY-OH with di(benzotriazolyl)carbonate in an organic solvent in the presence of base to thereby form a 1-benzotriazolylcarbonate ester product having a structure,

 where R? is as described in step (i).

US Pat. No. 10,456,473

LIPID COMPOSITIONS

Arbutus Biopharma Corpora...

1. A method of making a compound of formula (IV)
wherein each R is independently H, alkyl,

 provided that at least one R is

R1, for each occurrence, is independently H, R3,

 wherein R3 is optionally substituted with one or more substituent;
R2, for each occurrence, is independently, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of which is optionally substituted with one or more substituent;
R3, for each occurrence, is independently, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of which is optionally substituted with one or more substituent;
Y, for each occurrence, is independently, O, NR4, or S;
R4, for each occurrence, is independently, H alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of which is optionally substituted with one or more substituent;
the method comprising contacting an enantiomerically enriched ?-hydroxyalkyl synthetic equivalent that is a precursor to R, wherein the functional groups provided by the ?-hydroxyalkyl synthetic equivalent undergo further reactions to afford the final R group(s) in the compound of formula (IV), the ?-hydroxyalkyl group being optionally substituted with one or more substituent, with a compound of formula (VIII)
wherein R5, for each occurrence, is independently, H, alkyl, or an amine protecting group, wherein alkyl is optionally substituted with one or more substituent; and R6, for each occurrence, is independently, H, —(CH2)2N(R5)2, or an amine protecting group.

US Pat. No. 10,456,469

GLUTAMINE-HIGH Z ELEMENT COMPOUNDS FOR TREATING CANCER

SERBIG PHARMACEUTICALS CO...

1. A method for treating tumorigenic cells by targeting the cells mitochondria comprising:treating the tumorigenic cells with a radiosensitizing containing glutamine-ligand-high Z element compound and also treating the tumorigenic cells with a high energy radiation,
wherein the glutamine-ligand-high Z element compound is selected from the group consisting of the compounds provided below:

US Pat. No. 10,456,468

FRACTIONATED RADIOTHERAPY AND CHEMOTHERAPY WITH AN OXYGEN THERAPEUTIC

NuvOx Pharma LLC, Tucson...

1. A method of sensitizing a mammal to multi-fraction radiotherapy or chemotherapy, comprisingconcomitantly or up to 120 minutes prior to each fraction of radiation therapy or concomitantly with chemotherapy, administering a water emulsion of perfluoropentane to the mammal, wherein the perfluoropentane emulsion comprises a phospholipid, a viscosity modifier, a fluorosurfactant, and about 1% to 5% w/vol of perfluoropentane; and
simultaneously administering to said mammal carbogen or supplemental oxygen,wherein the perfluoropentane emulsion is administered at a dosage in the range from about 0.05 cc/kg to about 0.3 cc/kg.

US Pat. No. 10,456,467

NANOPARTICLE DELIVERY SYSTEM FOR TARGETED ANTI-OBESITY TREATMENT

UNIVERSITY OF WYOMING, L...

1. A method for making a magnetically responsive pharmaceutical, comprising:co-precipitating ferromagnetic metal salts and a TRPV1 protein agonist in the presence of ammonium hydroxide to form magnetic nanoparticles (MNPs); and
coating the MNPs and the TRPV1 protein agonist with a biodegradable polymer.

US Pat. No. 10,456,463

VACCINES COMPRISING CHOLESTEROL AND CPG AS SOLE ADJUVANT-CARRIER MOLECULES

Zoetis Belgium S.A, Brus...

1. A vaccine comprising one or more antigens and an adjuvant, the adjuvant consisting of one or more isolated immunostimulatory oligonucleotides and cholesterol admixed together, and wherein the one or more isolated immunostimulatory oligonucleotides comprises a modified internucleotide linkage or a modified nucleoside base and wherein said adjuvant consisting of one or more isolated immunostimulatory oligonucleotides and cholesterol admixed together is the sole adjuvant in the vaccine.

US Pat. No. 10,456,459

LIPOSOMAL ADJUVANT COMPOSITIONS

Zoetis Services LLC, Par...

1. An essentially saponin-free liposome, wherein said saponin is absent or present at or below the limit of detection, comprising an external lipid bilayer membrane and an internal compartment, the external membrane comprising:a) a quaternary ammonium compound composed of four alkyl chains, two of which are C10-C20 alkyls and the remaining two are C1-C4 alkyls;
b) a sterol selected from the group consisting of ?-sitosterol, stigmasterol, ergosterol, ergocalciferol, and cholesterol;
c) a phospholipid; and
d) a glycolipid of formula I:

wherein, R1 and R2 are independently hydrogen, or a saturated alkyl radical having up to 20 carbon atoms; X is —CH2—, —O— or —NH—; R2 is hydrogen, or a saturated alkyl radical having up to 20 carbon atoms; R3, R4, and R5 are independently hydrogen, —SO42?, —PO42?, —COC1-10 alkyl; R6 is L-alanyl, L-alpha-aminobutyl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutamyl, L-glycyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-ornithinyl, L-phenyalany, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, and L-valyl or their D-isomers.

US Pat. No. 10,456,450

COMPOSITIONS AND METHODS FOR TREATING ROTATOR CUFF INJURIES

BIOMIMETIC THERAPEUTICS, ...

1. A method for treating damaged or injured tissue comprising:providing a composition consisting essentially of a scaffolding material having a solution consisting essentially of of platelet-derived growth factor_(PDGF) and a buffer disposed therein, the scaffolding material consisting essentially of i) collagen or ii) collagen and a biocompatible binder, the scaffolding material having a porosity of at least 25%, and the solution having a PDGF concentration ranging from about 0.05 to about 5.0 mg/mL, and
applying the composition to the damaged or injured tissue.

US Pat. No. 10,456,430

LACTOBACILLUS COMPOSITION FOR PREVENTION AND TREATMENT OF BACTERIAL VAGINOSIS

Genmont Biotech Incorpora...

1. A method for treating bacterial vaginosis and regulating vaginal immunity comprising: administering to a subject a composition comprising an effective amount of Lactobacillus rhamnosus GMNL-680 with the deposition number CCTCC M 2017766 and Lactobacillus plantarum GMNL-682 with the deposition number CCTCC M 2017767; wherein the effective amount is at least 1010 CFU per day.

US Pat. No. 10,456,422

SURGICAL WOUND HEALING COMPOSITION AND METHOD OF APPLYING THE SAME

1. A method for improving the survival rate of a hair follicular graft during a hair transplantation surgery from a donor site to a recipient site, the method comprising injecting, proximal to the recipient site, a therapeutically effective amount of a suspension comprising:an autologous platelet solution above basal concentration;
granulated extracellular matrix; and
triamcinolone acetonide;
wherein administration of the therapeutically effective amount of the suspension is operative to decrease the scarring rate at the recipient site by more than 50%, increase the pigmentation retention rate of the hair follicular graft, and increase the survival rate of the hair follicular graft.

US Pat. No. 10,456,414

METHODS FOR TREATING HCV

Gilead Pharmasset LLC, F...

1. A composition comprising compound 10 having the structure:
or a pharmaceutically acceptable salt thereof, and compound 6 having the structure:

or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,456,413

COMBINATION THERAPY WITH SORAFENIB OR REGORAFENIB AND A PHOSPHORAMIDATE PRODRUG OF TROXACITABINE

Medivir Aktiebolag, Hudd...

1. A method for treatment of liver cancer or liver metastasis, comprising administering to a subject in need thereof a targeted therapeutic agent, wherein the targeted therapeutic agent is sorafenib or regorafenib, in combination with a phosphoramidate prodrug of troxacitabine with the formula:
wherein
Y is C1-C8 straight or branched chain alkyl;
X is H, halo, C3-C4cycloalkyl or C1-C4alkyl; and
Z is H or fluoro,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,456,408

METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME

ESSENTIALIS, INC., Redwo...

1. A method of reducing hyperghrelinemia in a subject having Prader-Willi syndrome (PWS) or Smith-Magenis syndrome (SMS), comprising administering to said subject for at least 10 weeks a pharmaceutical formulation comprising an effective amount of a KATP channel opener,and wherein the method does not comprise administering human growth hormone to the subject.

US Pat. No. 10,456,407

COMBINATION THERAPY FOR TREATING CANCER

Epizyme, Inc., Cambridge...

1. A method for treating renal cancer in a patient in need thereof comprising administering a therapeutically effective amount of an EZH2 inhibitor and one or more tyrosine kinase inhibitors;wherein the EZH2 inhibitor is GSK-126 having the following formula:
or a pharmaceutically acceptable salt thereof;ora compound of Formula (I):
or a pharmaceutically acceptable salt thereof;wherein:R701 is H, F, OR707, NHR707, —(C?C)—(CH2)n7—R708, phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl, or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is optionally substituted with one or more groups selected from halo, C1-3 alkyl, OH, O—C1-6 alkyl, NH—C1-6 alkyl, and, C1-3 alkyl substituted with C3-8 cycloalkyl or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein each of the O—C1-6 alkyl and NH—C1-6 alkyl is optionally substituted with hydroxyl, O—C1-3 alkyl or NH—C1-3 alkyl, each of the O—C1-3 alkyl and NH—C1-3 alkyl being optionally further substituted with O—C1-3 alkyl or NH—C1-3 alkyl;
each of R702 and R703, independently is H, halo, C1-4 alkyl, C1-6 alkoxyl or C6-C10 aryloxy, each optionally substituted with one or more halo;
each of R704 and R705, independently is C1-4 alkyl;
R706 is cyclohexyl substituted by N(C1-4 alkyl)2 wherein one or both of the C1-4 alkyl is substituted with C1-6 alkoxy; or R706 is tetrahydropyranyl;
R707 is C1-4 alkyl optionally substituted with one or more groups selected from hydroxyl, C1-4 alkoxy, amino, mono- or di-C1-4 alkylamino, C3-8 cycloalkyl, and 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is further optionally substituted with C1-3 alkyl;
R708 is C1-4 alkyl optionally substituted with one or more groups selected from OH, halo, and C1-4 alkoxy, 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, or O—C1-6 alkyl, wherein the 4-7 membered heterocycloalkyl can be optionally further substituted with OH or C1-6 alkyl; and
n7 is 0, 1 or 2.

US Pat. No. 10,456,405

NITRIC OXIDE-RELEASING PRODRUG MOLECULE OF SUBSTITUTED QUINAZOLINES

ZHEJIANG HUAHAI PHARMACEU...

5. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt or stereoisomer thereof, and one or more pharmaceutically acceptable carriers and/or diluents.

US Pat. No. 10,456,402

7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5 (1H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY

Oncoceutics, Inc., Phila...

1. A method of treatment comprising administering to a subject having a uterine cancer in need of such treatment a pharmaceutically acceptable amount of compound (1):
or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable amount of compound (1) is administered as a salvage therapy.

US Pat. No. 10,456,398

INHIBITION OF SGK1 IN THE TREATMENT OF HEART CONDITIONS

Beth Israel Deaconess Med...

1. A method for treatment of a cardiovascular disease in a subject, the method comprising, administering to the subject a therapeutically effective amount of at least one SGK1 inhibitor having the Formula 1:
wherein:
n is 1, 2, 3, 4, or 5;
each R is independently selected from the group consisting of hydrogen, a halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, CN, CO2H, CO2(C1-C6 alkyl), CO2(C1-C6 haloalkyl), —OH, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —SH, and —S(C1-C6 alkyl);
or a pharmaceutically acceptable salt thereof,
wherein the cardiovascular disease is selected from the group consisting of heart failure, arrhythmia, ischemic injury, ischemic infarction, cardiac fibrosis, vascular proliferation, restenosis, dilated cardiomyopathy, and stent failure.

US Pat. No. 10,456,397

COVALENT INHIBITORS OF CDK-7

Newave Pharmaceutical Inc...

1. A method of treating a neoplastic disease, comprising administering to a subject in need thereof an effective amount of a compound of Formula (I), or an N-oxide thereof, a pharmaceutically acceptable salt, polymorph, tautomer, stereoisomer, or an isotopic form thereof:whereinA is cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, fused hetero-bicyclic, or spiro-heterocyclic;
each of B, and C, independently, is cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, or heteroaryl;
each of Z1, Z2, Z3, and Z4 independently, is a bond, (CRaRb)p, (CRaRb)pN(Ra)(CRaRb)q, N(Ra)(CRaRb)qN(Ra), (CRaRb)pO(CRaRb)q, (CRaRb)pC?C(CRaRb)q, (CRaRb)pC?C(CRaRb)q, C(Ra)?N, O, S, C(O), N(Ra), S(O2), OC(O), C(O)O, OSO2, S(O2)O, C(O)S, SC(O), C(O)C(O), C(O)N(Ra), N(Ra)C(O), S(O2)N(Ra), N(Ra)S(O2), OC(O)O, OC(O)S, OC(O)N(Ra), OC(O)N(Ra)(CRaRb)p+1N(Ra)(CRaRb)q, N(Ra)C(O)O, N(Ra)C(O)S, N(Ra)C(O)N(Rb), (CRaRb)pN(Ra)C(O)(CRaRb)q, or (CRaRb)pC(O)N(Ra)(CRaRb)q;
each of m, n, p, and q independently, is 0, 1, 2, 3, or 4;
Warhead is

L1 is N(R7) if the atom which L1 connects to ring A is a carbon atom; or L1 is a direct bond if ring A is a heterocycloalkyl, heterocycloalkenyl, or heteroaryl and the atom which L1 connects to ring A is a nitrogen atom;
L2 is (CRaRb)SCH?HC(CRaRb)r in which each of r, and s independently, is 1, 2, 3, or 4;
each of W1, and W2 independently, is C(R4) or N;
each of R1, R2, R3, R4, R5, R6, and R7, independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, halo, nitro, oxo, cyano, —ORa, —SRa, —NRbRc, —C(O)Ra, —S(O)Ra, —SO2Ra, —P(O)RbRc, —C(O)N(Rb)Ra, —N(Rb)C(O)Rc, —C(O)ORa, —OC(O)Ra, —SO2N(Rb)Rc, —N(Rb)SO2Rc, -alkyl-Ra, -alkyl-C(O)Ra, -alkyl-NRbRc, -alkyl-C(O)N(Rb)Rc, -alkyl-N(Rb)C(O), or -alkyl-N(Rb)SO2Rc; and
each of Ra, Rb, Ra, Rb, and Rc, independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, halo, cyano, amine, nitro, hydroxy, —C(O)NHOH, alkoxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylamino, dialkylamino, or alkylamino.

US Pat. No. 10,456,395

SUBSTITUTED DIPYRIDO[1,2-A:1?,2?-D]PYRAZINES FOR TREATING VIRAL INFECTIONS

Gilead Sciences, Inc., F...

1. A compound having a Formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
L is —C(Ra)2—;
X is —CHR2—;
W is —CHR3—;
Z is —CHR4—;
each Ra is independently hydrogen, halogen, hydroxy or C1-4alkyl;
R1 is phenyl, substituted with one, two or three halogens;
R2 is hydrogen or C1-3alkyl;
R3 is hydrogen or C1-3alkyl;
R4 is hydrogen or C1-3alkyl;
R5 is hydrogen, C1-3alkyl or C1-3haloalkyl;
Y1 is hydrogen, C1-3alkyl or C1-3haloalkyl; and
Y2 is hydrogen, C1-3alkyl or C1-3haloalkyl.

US Pat. No. 10,456,394

TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS

THE BOARD OF TRUSTEES OF ...

1. A compound having Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
represents a single or double bond;
n=0, 1, or 2;
R1 and R2 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, trifluoromethyl, cyano, —NRaRb, —C(O)NRaRb, acetyl, C1-C6 alkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, or C5-C6 heterocyclyl;
Ra and Rb are independently selected from the group consisting of hydrogen, C1-C6 alkyl, or these groups may be joined to form a 3-7 membered heterocycyl;
A is CRcRd or C?O;
B is CRcRd when represents a single bond or CRc when represents a double bond;
D is CRcRd, C?O, NRe, O, S, S?O when represents a single bond or CRc or N when represents a double bond;
Rc and Rd are independently hydrogen, C1-C6 alkyl, or are joined together to form a 3-6 membered cycloalkyl;
Re is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, or C5-C6 heterocycloalkyl; and
R3 and R4 are independently selected from the group consisting of hydrogen and C1-C6 alkyl; in the case where one of R3 or R4 is a hydrogen atom, and the other group is alkyl, a chiral center is generated which may be of the R or S configuration.

US Pat. No. 10,456,393

TREATING PAIN IN PATIENTS WITH HEPATIC IMPAIRMENT

Persion Pharmaceuticals L...

1. A method of treating pain in a patient having mild or moderate hepatic impairment, the method comprising:administering to the patient having mild or moderate hepatic impairment a starting dose of an oral dosage unit having hydrocodone bitartrate as the only active ingredient, wherein the starting dose is not adjusted relative to a patient without hepatic impairment;
wherein the dosage unit comprises an immediate release component and an extended release component; and
wherein the dosage unit provides a release profile of hydrocodone such that:
the average hydrocodone AUC0-inf per 20 mg of hydrocodone bitartrate dosed to subjects suffering from mild hepatic impairment is in the range of about 316 ng*h/mL to about 564 ng*h/mL; and
the average hydrocodone AUC0-inf per 20 mg of hydrocodone bitartrate dosed to subjects suffering from moderate hepatic impairment is in the range of about 352 ng*h/mL to about 666 ng*h/mL.

US Pat. No. 10,456,392

HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS

Corcept Therapeutics, Inc...

1. A method of treating cancer, the method comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I, thereby treating the cancer, wherein the cancer is selected from the group consisting of breast cancer, prostate cancer, and ovary cancer, wherein the compound is administered in combination with an antineoplastic agent, and wherein the compound of Formula I has the formula:whereinR1 is selected from the group consisting of 2-pyrrole, 3-pyrrole, 3-pyrazole, 4-pyrazole, 5-pyrazole, 2-imidazole, 4-imidazole, 5-imidazole, 1,2,3-triazol-4-yl, 1,2,3,-triazol-5-yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, 1,2,3,4,tetrazol-5-yl, 2-furan, 3-furan, 2-oxazole, 4-oxazole, 5-oxazole, 3-isoxazole, 4-isoxazole, 5-isoxazole, 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,5-oxadiazol-3-yl, 1,3,4-oxadiazol-2-yl, 2-thiophene, 3-thiophene, 2-thiazole, 4-thiazole, 5-thiazole, 3-isothiazole, 4-isothiazole, 5-isothiazole, 1,2,3-thiadiazol-4-yl, 1,2,3-thiadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,2,5-thiadiazol-3-yl, 1,3,4-thiadiazol-2-yl, 2-pyridine, 3-pyridine, 4-pyridine, pyrazine, 2-pyrimidine, 4-pyrimidine, 5-pyrimidine, 6-pyrimidine, 3-pyridazine, 4-pyridazine, 5-pyridazine, and 6-pyridazine, optionally substituted with 1-4 groups each independently selected from R1a;
each R1a is independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —CN, N-oxide, C3-8 cycloalkyl, and C3-8 heterocycloalkyl;
ring J is selected from the group consisting of a cycloalkyl ring, a heterocycloalkyl ring, an aryl ring and a heteroaryl ring, wherein the heterocycloalkyl and heteroaryl rings have from 5 to 6 ring members and from 1 to 4 heteroatoms each independently selected from the group consisting of N, O and S;
each R2 is independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkyl-C1-6 alkoxy, —CN, —OH, —C(O)R2a, —C(O)OR2a, —C(O)NR2aR2b, —SR2a, —S(O)R2a, —S(O)2R2a, and C3-8 cycloalkyl;
alternatively, two R2 groups linked to the same carbon are combined to form an oxo group (?O);
alternatively, two R2 groups are combined to form a heterocycloalkyl ring having from 5 to 6 ring members and from 1 to 3 heteroatoms each independently selected from the group consisting of N, O and S, wherein the heterocycloalkyl ring is optionally substituted with from 1 to 3 R2d groups;
R2a and R2b are each independently selected from the group consisting of hydrogen and C1-6 alkyl;
each R2c is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, —CN, and —NR2aR2b;
each R2d is independently selected from the group consisting of hydrogen and C1-6 alkyl, or two R2d groups attached to the same ring atom are combined to form (?O);
R3 is selected from the group consisting of phenyl and pyridyl, each optionally substituted with 1-4 R3a groups;
each R3a is independently selected from the group consisting of hydrogen, halogen, and C1-6 haloalkyl;
subscript n is an integer from 0 to 3;
or salts thereof.

US Pat. No. 10,456,391

COMPOSITIONS AND METHODS FOR TREATING CARDIOMETABOLIC DISEASES AND DISORDERS

University of Prince Edwa...

1. A method of treating a cardiometabolic disease or disorder, said method comprising administering:100 mg to 400 mg Berberine,
75 mg to 300 mg alpha lipoic acid (LA),
and 50 mg to 200 mg Picrorhiza,
to a human subject in need thereof in an amount sufficient to ameliorate said cardiometabolic disease or disorder in said subject.

US Pat. No. 10,456,385

PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES

SK BIOPHARMACEUTICALS CO....

1. A method for treating an inflammatory disease in a patient, comprising:administering to the patient a therapeutically effective amount of a compound of Formula I:

or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein
A is C1-C10 heteroaryl optionally substituted by at least one selected from the group consisting of halo, chlorophenyl, C1-C6 alkyl, C3-C7 cycloalkyl, C6-C12 aralkyl, C1-C6 alkoxy, and C6-C12 aryl; and
B is O or NH.

US Pat. No. 10,456,382

COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT

FORMA TM, LLC, Watertown...

1. A compound of formula IIB or a pharmaceutically acceptable salt thereof:
wherein:
R is bicyclic heteroaryl comprising 1, 2, 3, or 4 heteroatom(s) independently selected from N, S, and O, wherein said heteroaryl may be substituted by one or more substituents selected from the group consisting of amino, oxo, and halo; and wherein said heteroaryl can comprise one or more N-oxide(s) formed with a N atom member of said heteroaryl;
R1is heteroaryl,
wherein:
(i) said heteroaryl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents which can be the same or different and are independently selected from the group consisting of:
deuterium, halo, hydroxy, hydroxyalkyl, cyano, —(CH2)mNRaRb, oxo, alkyl, cyanoalkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl-, alkenyl, alkynyl, alkynylalkoxy, —CONH2, —S-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(cycloalkyl), —C(O)NH(aryl), —C(O)N(aryl)2, arylalkyl-, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O)2-alkyl, —S(O)2-aryl, —S(O)2—CH,F3-z, —C(O)alkyl, —N(R5)—C(O)-alkyl, —N(R5)—C(O)-aryl, —S(O)2NH2, —S(O)2NH(alkyl), —S(O)2N(alkyl)2, —N(H)S(O)2(alkyl), and methylenedioxy, wherein each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may be substituted by one or more halo, cyano, alkyl, and alkoxy; and
(ii) said heteroaryl may optionally additionally be fused with independently selected heterocycloalkyl or cycloalkyl to form a bicyclic or tricyclic group that may be substituted by one or more halo, cyano, alkyl, and alkoxy;
R2 and R3 can be independently selected from the group consisting of H and deuterium;
R5 is H, alkyl, or arylalkyl;
Ra and Rb are independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl, and haloalkyl;
m is 0, 1, 2, 3, 4, 5, or 6; and
z is 0, 1, or 2.

US Pat. No. 10,456,379

IMIDAZOLE-BASED ANTIMICROBIAL AGENTS

Procomcure Biotech GmbH, ...

1. An antimicrobial composition comprising a compound consisting of the structural moiety of formula (I) or a pharmaceutically-acceptable salt of said compound, and a pharmaceutically acceptable carrier;
wherein
(i) Y is C;
(ii) R1 is selected from the group consisting of:
C3-6cycloalkyl, halogen, —(CH2)nN(CH3)2 where n is an integer from 1 to 3, benzyl optionally substituted on the phenyl ring, heteroaryl, and aryl, and
R2 is selected from the group consisting of:
H, —CH3, C2-6alkyl, C3-6cycloalkyl, halogen, —(CH2)nN(CH3)2 where n is an integer from 1 to 3, benzyl optionally substituted on the phenyl ring, and heteroaryl,
with the proviso that at least one of R1 or R2 possesses 3 or more carbon atoms; or
R1 and R2 are connected to form a four-, five- or six-membered non-aromatic carbocyclic ring thus providing a fused bicyclic moiety in which one or more of the carbon atoms of the ring comprising groups R1 and R2 is optionally replaced by a heteroatom selected from O, N, or S, and where one or more of the atoms of the ring comprising groups R1 and R2 is optionally substituted with one or more substituents independently selected from the group consisting of —CH3, C2-4alkyl, halogen, hydroxyl, —OCH3, —OC2-4alkyl, ethynyl, —OCF3, and —CF3; and
(iii) A is selected from the group consisting of

where * is the point of connection to the correspondingly-labeled atom of B and ** is the point of connection to the correspondingly-labeled atom of

wherein the aromatic ring of A is optionally substituted; and
(iv) B is aryl, heteroaryl, a bicyclic system comprising at least one aromatic ring, or styryl.

US Pat. No. 10,456,376

USE OF CARBAMATE COMPOUND IN ORDER TO PREVENTATIVELY TREAT HEADACHES

SK BIOPHARMACEUTICALS CO....

1. A method for prophylactically treating headaches in a subject, comprising:administering a therapeutically effective amount of a carbamate compound of Formula 1, or a pharmaceutically acceptable salt, solvate or hydrate thereof to the subject:

wherein,
R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, C1-C8 alkyl, halo-C1-C8 alkyl, C1-C8 thioalkoxy and C1-C8 alkoxy; and
one of A1 and A2 is CH, and the other is N.

US Pat. No. 10,456,375

SPECIFICALLY MESO-SUBSTITUTED PORPHYRINS AND CHLORINS FOR PHOTODYNAMIC THERAPY

Biolitec Unternehmensbete...

1. A compound based on the formulas 1, 2, 3, 4 or 5:Wherein:B is:

X is NH, O or S;
R1 is a linear or branched alkyl chain with 2-4 carbon atoms and containing at least one hydroxyl moiety;
R2 is a substituent either in the meta- or para-position of the phenyl ring with R2=—OH, —COOH, —NH2, —COOY, —NHY, OY, —NH—Z—COOH, or —CO—Z—NH2;
wherein
Y is a polyethyleneglycol-residue with (CH2CH2O)nCH3 with n=1-30 or a carbohydrate moiety;
Z is peptides or oligopeptides wherein n=1-30.

US Pat. No. 10,456,371

SUBSTITUTED ESTERS CONTAINING POLYOLS AND SACCHARIDES FOR TREATING HEPATOTOXICITY AND FATTY LIVER DISEASES

SINEW PHARMA INC., Taipe...

13. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

US Pat. No. 10,456,370

SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF

Enzo Therapeutics, Inc., ...

1. A method for treating asthma in a patient, comprising:administering to a patient in need of treatment for asthma a compound having the formula

US Pat. No. 10,456,369

METHODS AND COMPOSITIONS FOR IMPROVING THE HEALTH OF ANIMALS

Avivagen Inc., Ottawa (C...

1. A method of reducing shedding in a canine animal in need thereof, said method comprising administering to said canine animal a composition comprising an oligomeric material in an amount sufficient to reduce shedding, wherein said oligomeric material is formed by reaction of 6 to 8 molar equivalents of oxygen with a carotenoid and has a median molecular weight of about 900 Daltons, and wherein from 0.1 mg/kg body weight to 3 mg/kg body weight of said oligomeric material is administered to said canine animal daily.

US Pat. No. 10,456,360

STABILIZING CAMPTOTHECIN PHARMACEUTICAL COMPOSITIONS

Ipsen Biopharm Ltd., (GB...

1. A storage stabilized liposomal irinotecan composition comprising irinotecan sucrose octasulfate (SOS) encapsulated in liposomes comprised of cholesterol and one or more phospholipids with a ratio corresponding to a total of 500 grams±10% by weight irinotecan moiety per mol total phospholipids, the liposomal irinotecan composition stabilized to have less than 20 mol %, with respect to total phospholipids, of lyso-phosphatidylcholine (lyso-PC) during the first 6 months of storage of the liposomal irinotecan composition at a temperature ranging from 2 to 8° C., the liposomal irinotecan composition obtained by a process comprising the steps of:(a) forming liposomes comprising 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and methoxy-terminated polyethylene glycol-distearoylphosphatidyl ethanolamine, encapsulating a substituted ammonium salt of SOS with a sulfate concentration of from 0.4 to 0.5 M;
(b) contacting the liposomes with a solution comprising irinotecan, at a temperature above the transition temperature of the component phospholipids, thereby forming a preparation of liposomes encapsulating irinotecan sucrose octasulfate within the liposomes; and
(c) obtaining the storage stabilized liposomal irinotecan composition by at least one additional step comprising adjusting the pH of the preparation of liposomes from step (b) to a pH of from about 7.25 to about 7.50.

US Pat. No. 10,456,353

PERSONAL CARE COMPOSITIONS

CONOPCO, INC., Englewood...

1. A personal care composition comprising(i) an extract of Aloe vera; and
(ii) a hyaluronic acid polymer having a molecular weight from 5 to 60 kDa, the hyaluronic acid having the monomeric structure;
wherein the extract of Aloe vera comprises 60 to 95% by weight of hydrolysed polysaccharides having a molecular weight in the range of 2 to 3 kDa and 0.1 to 20% by weight polyphenols.

US Pat. No. 10,456,351

ORGANOPOLYSILOXANE

KAO CORPORATION, Tokyo (...

1. A method of setting hair, comprising:(1) applying a hair cosmetic to hair;
(2) setting said hair in a desired shape, before drying after said (1) applying; and
(3) removing an organic solvent from said hair cosmetic;
wherein the hair cosmetic comprises:
an organic solvent; and
an organopolysiloxane comprising:
(i) an organopolysiloxane segment as a main chain, and
(ii) two or more poly(N-acylalkyleneimine) segments each containing a repeating unit represented by formula (1):

wherein R1 represents a hydrogen atom, an alkyl group having 1 to 22 carbon atoms, an aralkyl group having 7 to 15 carbon atoms, or an aryl group having 6 to 14 carbon atoms, and n is 2 or 3,
wherein each poly(N-acylalkyleneimine) segment is bound to a silicon atom of said organopolysiloxane segment via an alkylene group comprising a hetero atom,
wherein a number-average molecular weight of each poly(N-acylalkyleneimine) segment is 800 g/mol to 1600 g/mol as measured by gel permeation chromatography,
wherein a weight-average molecular weight of said organopolysiloxane segment is 10,000 g/mol to 100,000 g/mol as measured by gel permeation chromatography,
wherein a mass ratio (a/b) of said organopolysiloxane segment (a) to said two or more poly(N-acylalkyleneimine) segments (b) is 65/35 to 82/18, as calculated from an NMR measurement, and
wherein a weight-average molecular weight (MWg) of a portion of said organopolysiloxane segment between adjacent poly(N-acylalkyleneimine) segments is 1700 g/mol to 3000 g/mol, wherein MWg is given by formula (I):

wherein Csi is a content percentage of the organopolysiloxane segment as a main chain, and MWox is a number-average molecular weight, as measured by gel permeation chromatography, of a poly(N-acylalkyleneimine) segment adjacent to said portion of said organopolysiloxane segment.

US Pat. No. 10,456,349

PRODUCT FOR KERATIN FIBERS, CONTAINING AT LEAST ONE COPOLYMER BASED ON VINYLPYRROLIDONE AND AT LEAST ONE COPOLYMER BASED ON ACRYLATES

1. A cosmetic agent for temporary shaping of keratinic fibers, comprising in a cosmetically tolerable vehicle:a) at least one copolymer A, consisting of at least one structural unit of formula (I) and at least one structural unit of formula (II) and at least one structural unit of formula (III):

where
R1 and R4 each independently of one another stand for hydrogen or a C1-4 alkyl group,
X stands for oxygen or an NH group,
Y stands for a C2-10 alkyl group,
R2, R3, R6, R8 each independently of one another stand for a C1-8 alkyl group,
R7 stands for a linear or branched, saturated or unsaturated C6-30 alkyl group and
X? stands for a physically tolerable anion,
b) at least one copolymer B comprising at least one structural unit of formula (IV) and at least one structural unit of formula (V) and at least one structural unit of formula (VI):

where
R8, R9 and R11 each independently of one another, stand for hydrogen or a C1-4 alkyl group,
R10 stands for a C1-6 alkyl group,
X stands for oxygen or an NH group,
A stands for a group *—(CH2CH2O)n—* or for a group *—(CH2CHMeO)m—* or for a group *—(CH2CH2O)n—(CH2CHMeO)m—* where n and m, each independently of one another, stand for integers from 5 to 35,
R12 stands for a linear or branched, saturated or unsaturated C8-30 alkyl group, and
c) at least one alkaline compound.

US Pat. No. 10,456,341

COMPOSITIONS AND METHODS FOR SIMULTANEOUS RESHAPING AND DIRECT COLORING OF HAIR

ALFA PARF GROUP S.P.A., ...

1. A ready-to-use composition for simultaneous reshaping and coloring of hair comprising at least one direct dye and a compound of formula (I) or the corresponding monohydrate of formula (II), respectively,
wherein X is either a hydroxy group, or X is a —NHR group wherein R represents an amino acid residue and the N atom is the amino group of the corresponding amino acid, said compounds of formula I or II being present in a concentration from 5.5 to 25% by weight,
and wherein said composition is characterized by a pH between 0.5 and 3.0.

US Pat. No. 10,456,334

CREAM-TYPE HAIR COLORING AGENT

1. Agent for oxidative hair dyeing comprising, relative to the weight of the agent,from about 60 to about 83 wt. % water,
at least one oxidation dye precursor,
at least one alkalizing agent,
at least one cross-linked copolymer, constructed from acrylic acid and non-ethoxylated esters of acrylic acid with linear C10-C30 mono-alcohols as monomers, wherein the cross-linked copolymer is included in a total quantity of from about 0.08 to about 0.8 wt. %, relative to the weight of the agent,
at least one linear, saturated 1-alkanol with a hydroxy group and from about 8 to about 22 carbon atoms in a total amount of from about 8 to about 15 wt. %,
at least one saturated or unsaturated alkane carboxylic acid with from about 14 to about 22 carbon atoms or a salt thereof in a total amount of from about 0.1 to about 2 wt. %,
in a total quantity of from about 1 to about 5% wt. %, at least one glycerol fatty acid from Formula (I)
whereR1, R2 and R3 each independently of one another denote a hydrogen atom or a grouping in Formula (II),
whereR4 denotes an unbranched or branched, saturated or unsaturated C11-C27 alkyl group, providing that at least one and a maximum of two of the radicals, selected from R1, R2, and R3, denotes a grouping of Formula (II);
in addition to the aforementioned substances, at least one other surfactant, selected from anionic, zwitterionic, amphoteric and non-ionic surfactants and mixtures thereof, in a total quantity of from about 1 to about 6 wt. %, and which do not contain any oxidants, and
at least one of branched alkanol with a hydroxy group and from about 10 to about 50 carbon atoms,
wherein the agent has a viscosity of from about 22,000 to about 27,000 mPas when measured at 20° C. using a rotational viscometer at a rotational frequency of 7.2 s?1 with measurement geometry SV II.

US Pat. No. 10,456,333

DENTAL ADHESIVE

KURARAY NORITAKE DENTAL I...

1. A dental adhesive comprising:a (meth)acrylamide compound (a);
an asymmetric acrylamide-methacrylic acid ester compound (b); and
an acid group-containing (meth)acrylic polymerizable monomer (c),
wherein the (meth)acrylamide compound (a) is at least one compound selected from the group consisting of compounds represented by the following general formula (1), and compounds represented by the following general formula (2), and
wherein the asymmetric acrylamide-methacrylic acid ester compound (b) is a compound represented by the following general formula (3),

wherein R1 represents a hydrogen atom or a methyl group, 1 represents an integer of 1 to 6, X represents an optionally substituted, linear or branched C1 to C8 alkylene group, the plurality of R1 may be the same or different, and the plurality of X may be the same or different,

wherein m represents 2 or 3, R1 and X are as defined above, the plurality of R1 may be the same or different, and the plurality of X may be the same or different,

wherein Z is an optionally substituted, linear or branched C1 to C8 aliphatic group or an optionally substituted aromatic group, the aliphatic group being optionally interrupted by at least one linking group selected from the group consisting of —O—, —S—, —CO—, —CO—O—, —O—CO—, —NR2—, —CO—NR2—, —NR2—CO—, —CO—O—NR2—, —O—CONR2—, and —NR2—CO—NR2—, and R2 represents a hydrogen atom, or an optionally substituted, linear or branched C1 to C8 aliphatic group.

US Pat. No. 10,456,332

CONTROLLED DOSAGE FORM-DISPENSING SYSTEM

P.C.O.A. DEVICES LTD., T...

1. A controlled dosage form-dispensing device, comprising:a. a multi-chamber, bulk medicine storage and distribution unit, wherein said unit is provided with a plurality of individual dosage form-containing storage chambers with respective delivery ports;
a personal medication dispenser comprising:
a fixed dosage form extracting station comprising a dosage form receiving and extracting mechanism; and
a pair of chutes to receive and deliver the dosage form to either at least one portable dosage form-dispensing cassette or to a dispensing receptacle, said chutes being selectively opened and closed by a pivoting hatch;
wherein said personal medication dispenser is provided with a controller which moves said bulk medicine storage and distribution unit sequentially bringing said respective delivery port of a predetermined chamber into register with said fixed dosage form extracting station such that said dosage form receiving and extracting mechanism extracts and receives only one dosage form at a time;
c. the at least one portable dosage form-dispensing cassette having a plurality of compartments and a first delivery controller for delivery of a predetermined dosage form from a predetermined compartment of said portable dosage form-dispensing cassette, said at least one portable dosage form-dispensing cassette being releasably attachable to the personal medication dispenser; and
d. a second delivery controller for the controlled delivery of predetermined dosage forms from said multi-chamber, bulk medicine storage and distribution unit to said portable dosage form-dispensing cassette via one of said chutes.

US Pat. No. 10,456,331

FEEDING ASSEMBLY TO FILL CAPSULES WITH GRANULES, IN PARTICULAR MICROGRANULES

MG 2-S.R.L., Lovalita Pi...

1. A feeding assembly to fill capsules (3) with granules (2), each capsule (3) comprising a respective bottom (4) and a lid to close the bottom (4), the feeding assembly comprising a filling drum (5), which is mounted so as to continuously rotate around a rotation axis (6), and is provided with a plurality of fillers (8) distributed around the rotation axis (6); and a hopper (20; 26) containing the granules (2); each filler (8) comprising a suction pipe (9), which can be connected to a pneumatic sucking device, is coupled to the filling drum (5) so as to carry out, relative to the filling drum (5), straight movements parallel to the rotation axis (6), and has a lower end (12) to pick up/release the granules (2); and being characterized in that the lower end (12) of each suction pipe (9) is closed by a closing element (13) provided with a plurality of openings (14), each designed so as to prevent the granules (2) from getting into the suction pipe (9);wherein the hopper (20; 26) has a longitudinal axis (21; 27), which is parallel to and distinct from said rotation axis (6); and
wherein the hopper (20) comprises a vibrating distribution plate provided with a feeding track (23), which is wound in a helical shape around and along said longitudinal axis (21), so as to feed the granules (2), in succession, to a transfer station (24) to transfer the granules (2) to the fillers (8).

US Pat. No. 10,456,330

CAPSULE FILLING MACHINE

Robert Bosch GmbH, Stutt...

12. A method of operating a capsule filling machine of claim 1, the method comprising:providing the capsule filling machine of claim 1;
positioning one of the capsules such that the upper capsule part (21) is disposed in the upper capsule part receptacle (31) and the lower capsule part (22) is disposed in the lower capsule part receptacle (32);
linearly moving the separating pin (34) until the sensor (41) is moved into the lower capsule part receptacle (32) and the lower capsule part (22) is detected;
activating the vacuum generator (33) to pull the lower capsule part (22) linearly away from the upper capsule part (21); and
after activating the vacuum generator, retracting the separating pin (34) away from the lower capsule part (22).

US Pat. No. 10,456,329

SYSTEM FOR CLOSED TRANSFER OF FLUIDS

Becton Dickinson and Comp...

5. A system for closed transfer of fluids comprising:a syringe adapter comprising:
a housing having a first end and a second end, the first end configured to be secured to a first container;
a cannula having a first end and a second end, the second end positioned within the housing;
a collet having a first end and a second end, at least a portion of the collet received within the housing, the collet comprising a body defining a passageway, a seal member, and a locking member connected to the body via a plurality of arms, the locking member forming a part of at least a portion of the plurality of arms and protruding radially inward from an inner surface of an end of at least a portion of the plurality of arms opposite the body and radially outward from an outer surface of the end of at least a portion of the plurality of arms opposite the body, wherein an inner surface of the housing defines a recess configured to receive a portion of the locking member that protrudes radially outward from the outer surface of the end of the plurality of arms, wherein the collet is axially movable from a first axial position where the locking member is open to receive a mating connector to a second axial position where radially outward movement of the locking member is restricted, the locking member moving radially inward upon movement of the collet from the first axial position to the second axial position, and wherein the recess of the housing receives the portion of the locking member that protrudes radially outward from the outer surface of the end of the plurality of arms when the collet is in the first axial position; and
a connection arrangement having a first connection interface, the first connection interface is configured to engage a second connection interface; and
a second component comprising a membrane and a collet interface surface configured to receive and engage the locking member of the collet.

US Pat. No. 10,456,328

AMPOULE FOR MEDICAL LIQUID AND METHOD FOR PRODUCING AN AMPOULE

Fresenius Kabi Deutschlan...

1. A combination comprising:an ampoule produced by blowing, filling, and sealing, wherein the ampoule includes an ampoule body, a connection part, and a break-off part, the break-off part being integral with the connection part, wherein there exists a predetermined breaking point to mark where the break-off part is to be broken off from the connection part, the connection part extending along a longitudinal direction and being integral with the ampoule body, wherein an outer face of the connection part forms a threaded portion that comprises first and second threads arranged thereon, the first and second threads being offset axially relative to each other along the longitudinal direction; and
a removal device including an injection body and a Luer cone arranged on said injection body, wherein the connection part of the ampoule including an inner wall that defines an opening for receiving said Luer cone, wherein, after the opening has received the Luer cone, the removal device becomes completely connected, wherein, when the removal device is completely connected, a sealing face that extends along the longitudinal direction by at least a millimeter along the inner wall forms a seal between the Luer cone and the inner wall, and wherein, when the removal device is completely connected, the Luer cone is disposed within the connection part but does not enter the ampoule body.

US Pat. No. 10,456,327

PACKAGE FOR FROZEN NUTRIENT PILL

1. A package comprising:a plurality of seamless compartments coupled together;
a different one of said plurality of compartments each including a different respective one of a plurality of respective void spaces and each including a different respective one of one of a plurality of respective void space delimiting surfaces;
a plurality of fill entries, a different one of each said fill entries of said plurality forms a fluent entry into a different one of each of said compartment's respective void space;
a plurality of receptacles, a different one of said plurality of receptacles each include a respective different one of said plurality of void space delimiting surfaces and an external surface, said external surface of each receptacle including a curvilinear portion, the entirety of the curvilinear portion on one side of a support which couples the receptacles together;
wherein at least one fill entry of said plurality forming the fluent entry in one of said compartment's void space is in an elastomeric portion of said package, and said at least one fill entry has a width measured along its minor axis or a diameter which is less than the width of the of the compartment having the at least one fill entry forming the fluent entry into the compartment's void space, wherein the width of the compartment is measured along the compartments minor axis;
wherein each compartment of said plurality has a volume from 0.7 ml to 4 ml; and
wherein each void space delimiting surface of said plurality follows an outline of a separate 3D pill shape; and
wherein each of said fill entries of said plurality of said fill entries circumscribes a different one of said void space delimiting surfaces.

US Pat. No. 10,456,326

SYSTEMS AND METHODS FOR MONITORING MEDICATION ADHERENCE AND COMPLIANCE

VERILY LIFE SCIENCES LLC,...

1. A medication monitoring system comprising:a medication container and a cover, the cover configured to engage with one or more threads on the medication container to seal the medication container; and
a beacon system comprising:
a sensor positioned to detect a disengagement of the cover from the one or more threads on the medication container; and
a beacon in communication with the sensor, the beacon configured to transmit a wireless signal in response to the sensor detecting the cover disengaging from the one or more threads on the medication container.

US Pat. No. 10,456,325

MICRO FACIAL MASSAGER

1. A micro facial massager, comprising:a housing;
a circuit board;
a driving motor;
an eccentric wheel arranged on an output shaft of the driving motor;
a massage piece;
at least one battery positioned in a placed groove of a battery box;
two metal connectors; and
wherein a through hole is defined in a bottom of the placed groove; the battery box is dismountable and is insertable into the housing; the two metal connectors are corresponding fixed in the housing and are connected with the circuit board; the two metal connectors press an anode and a cathode of the at least one battery when the battery box is inserted into the housing, respectively;
two supporting structures are formed on a first side of the housing to hold up the battery box, and two sliding structures are formed on two sides of the battery box to engage with the two supporting structures, respectively; a clamp is formed on a top end of each of the two sliding structures, a stuck column is formed on a front end of each of the two supporting structures to engage with the clamp.

US Pat. No. 10,456,324

SEX TOY WITH A PLURALITY OF SEPARATE HEAD PORTIONS

1. A sex toy comprising:a handle member forming a generally cylindrical handle body which can be manually grasped and held;
the handle member comprising a connector portion at least at one end of the handle body;
and a plurality of separate selectable penetrative head portions for engaging onto the connector portion of the handle member and each having a generally cylindrical penetrative portion arranged to extend forwardly from the handle member, the separate selectable head portions having different outside shapes and/or dimensions;
the separate selectable head portions being arranged such that each can be engaged separately onto the connector portion of the handle member when selected;
wherein the handle member comprises a releasable fastener at said at least one end of the handle body with a manually operable release;
wherein the connector portion of the handle member comprises an elongate stiffening core extending longitudinally and coaxially of the generally cylindrical handle body to a position beyond said at least one end of the handle body and the releasable fastener thereon;
the elongate stiffening core having a transverse dimension less than that of the handle body;
each of said separate selectable penetrative head portions including a hollow interior defining an elongate receptacle therein for engaging onto the stiffening core;
each of said separate selectable penetrative head portions including a connector thereon for releasably engaging the releasable fastener of the handle member.

US Pat. No. 10,456,322

MASSAGE SHOWER HEAD

PURITY (XIAMEN) SANITARY ...

1. A massage shower head, comprising a main body, a water outlet cover and a plurality of massage balls; the main body being provided with a water inlet, a front of the main body being defined as a water outlet side, the water outlet cover covering the water outlet side of the main body, the massage balls being movably disposed between the main body and the water outlet cover, the water outlet cover having a plurality of openings, the massage balls partially extending out from the openings respectively, and further comprising a multifunctional sealing seat and a water outlet sleeve; the multifunctional sealing seat being mounted on the front of the main body, the multifunctional sealing seat being provided with a plurality of water drain holes communicated with the water inlet; the water outlet cover covering the multifunctional sealing seat, an inner side of the water outlet cover being formed with a plurality of partitions, the partitions dividing the inner side of the water outlet cover into a plurality of independent water chambers and accommodation chambers, the water chambers being in communication with the plurality of water drain holes respectively, the water outlet cover being formed with a plurality of insertion holes corresponding in position to the water chambers, the water outlet sleeve being disposed between the water outlet cover and the multifunctional sealing seat and attached to the inner side of the water outlet cover, the water outlet sleeve being formed with a plurality of guide posts with water apertures corresponding to the insertion holes, the guide posts passing through the insertion holes of the water outlet cover respectively; the massage balls being movably disposed in the accommodation chambers respectively, the openings corresponding in position to the accommodation chambers.

US Pat. No. 10,456,321

FLUID SKIN TREATMENT SYSTEMS AND METHODS

1. A microdermabrasion system for treating a tissue for use with a fluid source and a negative-pressure source, the system comprising:a device body having an applicator end, the applicator end comprising a tissue contact surface having a recess within the applicator end;
at least one fluid opening configured to deliver a fluid from the fluid source to the skin contact surface located towards an outer edge of the recess;
at least one negative pressure opening located at a center of the recess and fluidly coupled to the negative pressure source, such that application of the negative pressure source causes tissue to be drawn into the recess against the tissue contact surface, wherein when the tissue is positioned against the applicator end, the negative pressure source pulls the fluid from the at least one fluid opening; and
at least one vibratory element positioned in the device body, where actuation of the vibratory element causes a vibratory motion of the applicator end such that the tissue contact surface applies a vibratory force to the tissue.

US Pat. No. 10,456,320

HAND AND FOOT WRAPS

CoolSystems, Inc., Conco...

1. A therapy wrap for treating a hand of a patient, the therapy wrap comprising:a sleeve comprising a palm facing portion, a forearm wrap portion and a hand covering portion;
a hand support disposed within the palm facing portion of the sleeve, the hand support having a convex, curved palm facing surface configured to conform to a shape of the patient's hand in a relaxed state;
a therapy component comprising a heat exchanger disposed in both the palm facing portion, the forearm wrap portion and the hand covering portion of the sleeve, the heat exchanger comprising a compliant fluid bladder; and
a base plate having a slot wherein when the therapy wrap is in use treating the hand of a patient the therapy component is in the slot with the heat exchanger disposed in the hand covering portion on one side of the base plate and the heat exchanger disposed in the palm facing portion on another side of the base plate.

US Pat. No. 10,456,319

FASCIA THERAPY TOOL

1. A rigid tool for use in fascia therapy comprising a handle portion and a blade portion;the handle portion comprising an elongate cylinder having a length from three to five inches and a diameter from three-quarters of an inch to two inches defining a central longitudinal axis;
the blade portion comprising a flat plate having a thickness from one-eighth to three-eighths of an inch and a width from three to five inches, the width being measured from a first transverse side edge to a second transverse side edge and approximately equal to and aligned with the length of the handle portion, and the blade portion being rigidly affixed at a proximal end thereof to and extending out from the handle portion co-planarly with the longitudinal axis; wherein
the blade portion further comprises a distal edge having a curved contour devoid of sharp corners across the width, rounded corners at the intersections of the distal edge and the side edges, and a rounded shape across the thickness.

US Pat. No. 10,456,318

GAIT REHABILITATION SYSTEMS, METHODS, AND APPARATUSES THEREOF

The Trustees of the Unive...

1. A gait rehabilitation method comprising:sensing at least one parameter associated with a gait of an individual, the individual having an affected leg and an unaffected leg;
determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter; and
applying a braking force resisting forward movement of the individual during the determined modification portion, wherein the individual wears a harness that is attached to a brake by a tether wound on a spool of the brake and wherein the periodically applying a braking force comprises applying the brake to the spool to increase resistive force needed to unwind the tether from the spool.

US Pat. No. 10,456,317

SYSTEM AND METHOD FOR CONTROLLING JOINT ANGLE OF KNEE-JOINT TYPE WALKING TRAINING ROBOT

KOREA POLYTECHNIC UNIVERS...

1. A system for controlling a joint angle of a knee-joint type walking training robot, the system comprising:a pressure measuring apparatus configured to measure a pressure of a sole of a foot of a walker by using a pressure sensor; and
a joint angle estimating apparatus configured to estimate a joint angle of a knee-joint by extracting a movement time period for walking and a length by which the foot sole makes contact with a ground surface based on the pressure of the foot sole measured by the pressure measuring apparatus,
wherein the joint angle estimating apparatus comprises:
a receiver for receiving pressure values transmitted by a transmitter;
a pressure extracting circuit configured to estimate a gait phase for the received pressure values; and
a joint angle estimating circuit configured to estimate the joint angle of the knee-joint during walking by estimating an angle between the foot sole and the ground surface according to the gait phase estimated by the pressure extracting circuit.

US Pat. No. 10,456,316

ACTUATORS AND METHODS OF USE

Worcester Polytechnic Ins...

20. A lattice device comprising:a first member;
a second member; and
an actuator connected to the first member at a first end of the actuator and to the second member at a second end of the actuator, the actuator comprising:
an inner member made from an elastic material and having straight walls to define a straight, cylindrically shaped compartment for receiving an actuating fluid, the inner member being moveable in an axial direction from a relaxed state to an expanded state by introducing an actuating fluid into the inner member to pressurize the inner member; and
an outer member being disposed immediately adjacent to and around the elastic inner member to control expansion of the elastic inner member in a radial direction, the outer member being inelastic in the radial direction and expandable in the axial direction as the inner member moves from the relaxed state to the expanded state,
wherein, when the inner member is pressurized to move the inner member to its expanded state, the actuator expands in the axial direction, and
wherein, when the inner member is de-pressurized to return the inner member to its relaxed state, the actuator contracts in the axial direction to cause a movement of at least one of the first member and the second member relative to the other member, and
wherein the outer member is made of a foldable material such that:
when the inner member moves from its expanded state to its relaxed state, the outer member freely folds onto itself to create a plurality of free form folds, wherein at least some of the folds of the plurality of free form folds form one or more overlaps with one another, and
when the inner member moves to its expanded state, the plurality of folds of the outer member unfold to enable the outer member to expand in the axial direction.

US Pat. No. 10,456,315

USER-ACTUATED DYNAMIC TENSION TRACTION APPARATUS

Innovatio Devices LLC, M...

1. A portable apparatus for spinal decompression therapy, comprising:a first frame assembly, the first frame assembly having an attachment means configured to selectively couple to a bottom portion of a door;
a second frame assembly, the second frame assembly having an attachment means configured to selectively couple to a top portion of a door;
at least one first resistance band having a first end and a second end, the first end of the at least one first resistance band being removably coupled to a right-side portion of the first frame assembly, and the second end of the at least one first resistance band being removably coupled to a right-side portion of the second frame assembly;
at least one second resistance band having a first end and a second end, the first end of the at least one second resistance band being removably coupled to a left-side portion of the first support frame, and the second end of the at least one first resistance band being removably coupled to a left-side portion of the second support frame; and,
a neck collar having a first attachment means selectively attached to the at least one first resistance band, and a second attachment means selectively attached to the at least one second resistance band, the collar being configured to be selectively coupled around the head of a user.

US Pat. No. 10,456,314

RANGE OF MOTION DEVICE

Bonutti Research, Inc., ...

1. An orthosis configured to stretch tissue around a foot and a toe of a wearer, said orthosis comprising:a first member affixable to the foot;
a second member operatively connected to the first member and affixable to the toe;
a gear fixedly connected to the second member and having a plurality of gear teeth, wherein the gear is configured to rotate relative to the first member to impart movement of the second member relative to the first member; and
a drive assembly operatively coupled to the gear and configured to drive rotation of the gear relative to the first member thereby driving movement of the second member relative to the first member such that the toe moves relative to the foot corresponding with said movement of the second member relative to the first member when the first member is affixed to the foot and the second member is affixed to the toe.

US Pat. No. 10,456,313

CREMATION URN

1. A cremation urn for storing cremated remains, includes:a base, said base including an edge that extends a perimeter of said base;
a front wall, said front wall extending generally upward at a first outward angle from said edge of said base;
a rear wall, said rear wall extending generally upward at a second outward angle from said edge of said base, said rear wall opposite said front wall;
a first side wall extending generally upward at a third outward angle from said edge of said base, said first side wall intersecting said front wall and said rear wall;
a second side wall extending generally upward at a fourth outward angle from said edge of said base, said second side wall opposite said first side wall and said second side wall intersecting said front wall and said rear wall;
a top opening, said top opening created at a top of said front wall, said rear wall, said first side wall and said second side wall;
a lid, said lid covering said top opening;
a hinge, said hinge connected to said lid and said rear wall;
an interior cavity for receiving the cremated remains, said interior cavity created by the interior intersection of said front wall to said first side wall, said front wall to said second side wall, said rear wall to said first side wall, said rear wall to said second side wall and each of said front wall, said first side wall, said second side wall and said rear wall intersecting said edge of said base;
four corner beads, each of said corner beads configured at the intersection of said front wall to said side walls and said rear wall to said side walls and each of said four corner beads extending from said base to said top opening;
a plurality of stops, said plurality of stops positioned a distance above said base and said plurality of stops fixedly secured to each of said corner beads within said interior cavity and said plurality of stops including a rounded edge; and
wherein said front wall, said rear wall, said first side wall and said second side wall extend generally upward at said first outward angle, said second outward angle, said third outward angle and said fourth outward angle respectively from said base to said top opening to create a taper in said cremation urn;
wherein the tapering of said front wall, said rear wall, said first side wall and said second side wall enable a second cremation urn to pass through said top opening of said cremation urn to be nested within said interior cavity of said cremation urn;
wherein a second edge of a second base of said second cremation urn engages said plurality of stops of said cremation urn to facilitate the nesting and unnesting of multiple said cremation urns; and
wherein said second cremation urn rests freely within said interior cavity abutting said plurality of stops of said cremation urn to further facilitate the effortless removal of said second cremation urn from said interior cavity of said cremation urn.

US Pat. No. 10,456,312

EXAMINATION CHAIR

Images of America, Inc., ...

1. An examination chair comprising a seating surface; a back surface; a pair of arms, each arm disposed laterally outward and extending upward relative to an opposite side of the seating surface; a lift for raising and lowering the seating surface; and a pair of stirrup members, each stirrup member received within a respective arm; wherein each stirrup member comprises a foot stirrup; a stirrup slide and a stirrup slide tube; wherein the stirrup slide tube is disposed within a channel in the respective arm, the stirrup slide is disposed for sliding movement within the stirrup slide tube, and wherein the foot stirrup is connected to a terminal end of the stirrup slide.

US Pat. No. 10,456,311

EXCRETA DISPOSAL APPARATUS PROVIDED WITH ROTARY NOZZLE

Curaco, Inc., Seongnam-S...

1. An excreta disposal apparatus provided with a rotary nozzle, the apparatus comprising:a body comprising a seating unit, which has a shape corresponding to a curved shape of genital area and buttocks of a human body and also has a disposal space open toward the genital area and buttocks of the human body so as to take excreta discharged from the human body, a main body unit, which is connected to the seating unit so as to be mounted between legs of the human body and has an accommodation space therein;
a discharge channel, which is provided in the accommodation space and communicates with the disposal space so as to discharge the excreta in the disposal space to the outside; and
a spray unit exposed to the disposal space so as to spray washing water,
wherein the spray unit is provided at a position facing the user's anus while the user's body is seated on the seating unit, and comprises the rotary nozzle which is rotatable in an up-down direction around a central axis extending in a left-right direction to spray the washing water.

US Pat. No. 10,456,310

BED STEP STOOL AND METHOD OF USE

1. A bed step stool for assisting a user into and out of bed including opposite sides, a head, and a foot, comprising:a first support to be disposed closer to the head of the bed;
a second support to be disposed closer to the foot of the bed;
a step assembly supported between the first support and the second support, the step assembly to enable the user to step thereon for assisting the user into and out of the bed;
a bed attachment that couples the bed step stool to the bed to stabilize the bed step stool,
wherein the first support and the second support define an unobstructed pathway for entry and exit with respect to the bed and the bed step stool that is perpendicular with respect to the sides of the bed whereby the user goes between the first support and the second support to step onto the step assembly and off the step assembly without any obstruction.

US Pat. No. 10,456,309

FIELD CONFIGURABLE PATIENT SUPPORT APPARATUSES

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a frame;
a support surface adapted to support a patient thereon;
an antenna adapted to be affixed to packaging of the patient support apparatus; and
communication circuitry in communication with the antenna, the communication circuitry adapted to receive and store a configuration setting from an off-board device via the antenna while the patient support apparatus is contained within the packaging and not physically coupled to an external source of electrical power.

US Pat. No. 10,456,308

REMOVABLE LEG REST FOR WHEELCHAIRS

David Ditor, St. Cathari...

1. A removable leg rest for a wheelchair, the removable leg rest comprising:a) a base member configured to be mounted to a wheelchair frame having a wheelchair frame member;
b) a leg support member pivotally coupled to the base member;
c) an actuator for pivoting the leg support member relative to the base member between a lowered position and a raised position; and
d) a plurality of mounting clips for attaching the base member to the wheelchair frame member, the mounting clips each being configured to releasably engage a cross-sectional portion of the wheelchair frame member, and each clip including a connector for pivotally attaching the clip to the base member, the plurality of mounting clips include at least:
i) a first clip configured to engage a first cross-sectional portion of the wheelchair frame member; and
ii) a second clip configured to engage a second cross-sectional portion of the wheelchair frame member, the second clip is adjustably coupled to the base member for adjusting relative distance between the first clip and the second clip.

US Pat. No. 10,456,307

ADULT DISPOSABLE ABSORBENT ARTICLES AND ARRAYS OF SAID ARTICLES COMPRISING ABSORBENT CORES HAVING CHANNELS

1. An array of packages comprising two or more different sizes of disposable absorbent articles, the array comprising:a first package comprising a first disposable absorbent article, the first disposable absorbent article comprising a first topsheet, a first backsheet, a first absorbent core comprising first and second channels, and a first pair of side seams, the first absorbent article being a first size and in closed form;
a second package comprising a second disposable absorbent article, the second disposable absorbent article comprising a second topsheet, a second backsheet, a second absorbent core comprising third and fourth channels, and a second pair of side seams, the second absorbent article being a second size and in closed form;
wherein the second size is larger than the first size;
wherein a Channel Spacing of the first size is greater than a Channel Spacing of the second size; and
wherein the first package and the second package are in the same array.

US Pat. No. 10,456,306

ABSORBENT ARTICLES WITH IMPROVED ABSORPTION PROPERTIES

1. An absorbent article comprising a topsheet and a backsheet, and an absorbent structure comprising an absorbent core; wherein the absorbent article is divided into three portions: a front portion, a back portion and a crotch portion disposed between the front portion and the back portion, and wherein the absorbent article comprises an acquisition time for the first gush of less than about 27 s as measured according to the Flat Acquisition Test Method, wherein one or more portions of the absorbent structure comprises a Kmin/K20 ratio of 0.75 or greater.

US Pat. No. 10,456,305

PACKAGE FOR ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. A package comprising at least one stack of compressed absorbent articles, wherein each article extends in longitudinal direction and a transversal direction, and comprises:a topsheet;
a backsheet;
an absorbent core between the topsheet and the backsheet,wherein the absorbent core comprises an absorbent layer in a core wrap, the absorbent layer comprising an absorbent material and having a longitudinally extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;wherein the absorbent core further comprises a first folding guide between the central portion and the first side portion, and a second folding guide between the central portion and the second side portion;wherein each side portion comprises a plurality of winglets, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, and wherein neighboring winglets are separated by a gap between their neighboring sides;wherein each of the first folding guide and the second folding guide are substantially free of absorbent material;wherein each of the first folding guide and the second folding guide substantially continuously extend from a first location of a longitudinally-extending side edge of the absorbent core to a second location of the longitudinally-extending side edge of the absorbent core; andwherein in the package, the articles are bi-folded along a transversal fold line and are compressed at an In-Bag Compression Rate of from 5% to 50%.

US Pat. No. 10,456,304

TRANSPORT UNIT AND METHOD FOR MANUFACTURING DISPOSABLE WEARING ARTICLES USING SAME

ZUIKO CORPORATION, Osaka...

1. A transport unit configured to convey a first transportation object onto a second transportation object and join the first transportation object to the second transportation object, the transport unit comprising:a transporting device including a pad rotating shaft configured to rotate about a pad rotational axis, and a pad having a holding surface that faces radially outwardly with respect to the pad rotating shaft and is configured to hold the first transportation object, the transporting device being configured to rotate the pad about the pad rotating shaft and turn the pad about an axis extending in a radial direction of the pad rotating shaft while the pad is rotated from a receiving position where the pad receives the first transportation object to a transfer position where the pad transfers the first transportation object onto the second transportation object; and
a receiving roller that is configured to, when the pad rotates and comes to the transfer position, rotate while sandwiching the first transportation object and the second transportation object between the holding surface of the pad and the receiving roller, to join the first transportation object to the second transportation object and guide the second transportation object to a predetermined direction,
wherein:
the holding surface includes a first sloped surface and a second sloped surface, the first sloped surface and the second sloped surface being configured such that, when the pad is at the transfer position, a distance from the pad rotational axis to the first sloped surface decreases toward a first end along the pad rotating shaft, and a distance from the pad rotational axis to the second sloped surface decreases toward a second end along the pad rotating shaft;
the receiving roller includes a first receiving roller and a second receiving roller;
an outer diameter of the first receiving roller decreases from a proximal end of the first receiving roller to a distal end of the first receiving roller along a first rotational axis which is a rotation center of the first receiving roller, and the distal end of the first receiving roller is positioned on a side of the first end of the holding surface to sandwich the first transportation object and the second transportation object between the first sloped surface and the first receiving roller when the pad is at the transfer position; and
an outer diameter of the second receiving roller decreases from a proximal end of the second receiving roller to a distal end of the second receiving roller along a second rotational axis which is a rotation center of the second receiving roller, and the distal end of the second receiving roller is positioned on a side of the second end of the holding surface to sandwich the first transportation object and the second transportation object between the second sloped surface and the second receiving roller when the pad is at the transfer position.

US Pat. No. 10,456,303

METHOD OF MAKING A MECHANICAL FASTENING STRIP AND RETICULATED MECHANICAL FASTENING STRIP THEREFROM

3M Innovative Properties ...

1. A method of making a mechanical fastening strip, the method comprising:providing a thermoplastic backing having multiple rows of upstanding posts;
slitting through the thermoplastic backing to provide a slit backing having interrupted slits between at least some pairs of adjacent rows of the upstanding posts, wherein each interrupted slit is interrupted by at least one intact bridging region of the slit backing, and wherein the interrupted slits do not slit the upstanding posts;
spreading the slit backing to provide multiple strands of the thermoplastic backing attached to each other at least at some of the bridging regions and separated from each other between at least some of the bridging regions to provide at least one opening; and
fixing the multiple strands of the thermoplastic backing in a spread configuration to maintain the at least one opening between the multiple strands of the thermoplastic backing.

US Pat. No. 10,456,302

METHODS AND APPARATUS FOR APPLICATION OF NESTED ZERO WASTE EAR TO TRAVELING WEB

Curt G. Joa, Inc., Shebo...

1. A method of creating a disposable product, the method comprising:providing an extension panel web;
coupling tapes to a first edge and a second edge of said extension panel web;
folding said tapes over said first and second edges of said extension panel web;
bonding said extension panel web to a stretch laminate web at a first portion of said stretch laminate web and a second portion of said stretch laminate web to form a combination web;
slitting and spreading said combination web in a machine direction into first and second combination webs;
slitting said first and second combination webs in a cross-machine direction into first and second discrete combination web portions;
providing a side panel web having a top edge and a bottom edge;
intermittently coupling said first discrete combination web portion to said top edge of said side panel web;
intermittently coupling said second discrete combination web portion to said bottom edge of said side panel web;
folding said first and said second discrete combination web portions over said top and bottom edges of side panel web;
slitting and spreading said side panel web into a top side panel portion and a bottom side panel portion;
removing a portion of said side panel web from said top side panel portion between said discrete combination web portions;
removing a portion of said side panel web from said bottom side panel portion between said discrete combination web portions;
subsequently providing a chassis assembly having a top side portion and a bottom side portion;
intermittently coupling said top side panel portion to said top side of said chassis assembly;
intermittently coupling said bottom side panel portion to said bottom side portion of said chassis assembly; and
cutting said chassis assembly and said side panel portions in the cross-machine direction adjacently to said discrete combination web portions to create a single product.

US Pat. No. 10,456,301

THERMAL REFLECTIVE LAYER FOR A WOUND CARE DRESSING

HEALTHKO, LLC, Boca Rato...

1. A wound dressing, comprising:a top layer;
a bottom layer on an opposite side of the wound dressing from the top layer, the bottom layer comprised of a wound contact layer having a wound facing surface;
a thermal reflective layer disposed between the top layer and the bottom layer and comprising a plurality of thermal reflecting domes arranged in an array configuration with apexes of each dome of the plurality of thermal reflecting domes oriented toward the bottom layer of the wound dressing.

US Pat. No. 10,456,300

RING COMPRESSION BANDAGE

1. A toroidal compression bandage comprising:a tubular, circular core, the core comprised of a material to resist compression and to reduce blood flow into an injured area;
a sterile fibrous material, defined by an absorbency of a predetermined amount;
a torus ring compression bandage form comprised of the fibrous absorbent material in a rolled, wrapped tubular form, around the tubular, circular core, and of a tubular, circular shape defined by a circle revolved in three-dimensional space about a circular axis coplanar with the circle, wherein the axis of revolution does not touch the rotated circle, thereby to define a torus ring compression bandage for placement around a trauma wound to avoid direct contact of the trauma wound, and for absorption placement around the trauma wound;
an aperture defined within a center area of the torus ring compression bandage as it is formed, the aperture having a predetermined diameter and configured for placement directly over a trauma wound to avoid direct contact with the trauma wound, wherein the torus ring compression bandage is configured for placement circumferentially around the trauma wound and the aperture provides that no direct contact of the torus ring compression bandage is made to the trauma wound and for absorption placement circumferentially around the trauma wound; and
a compression surface defined on an underside of the torus ring compression bandage, the compression surface configured for circumferential placement on a surface around the trauma wound to avoid direct contact of the trauma wound, and for absorption placement around the trauma wound.

US Pat. No. 10,456,299

GOGGLES WITH INTERCHANGEABLE LENS ATTACHMENT

Maui Jim, Inc., Peoria, ...

1. A goggles device including a removable lens assembly, the goggles device comprising:an inner frame dimensioned and contoured for positioning against a wearer's face; and
a first lens assembly including:
a first lens formed and sized to extend across eyes of the wearer to cover the eyes and eye-adjacent area of the wearer, said lens having an arcuate shape across at least its longest axis; and
a plurality of inward-facing attachment structures of the lens assembly dimensioned to engage with corresponding outward-facing attachment structures of the inner frame,
wherein at least one of the plurality of inward-facing attachment structures is curved along its longitudinal axis and slidably removably engages with a complementarily curved at least one of the outward-facing attachment structures of the inner frame; and
configured such that engagement of the lens assembly with the inner frame describes a top-toward-bottom arced path, and disengagement of the lens assembly from the inner frame describes a bottom-toward-top arced path, said arced path being defined by the curved longitudinal axis of the at least one of the plurality of inward-facing attachment structures, the complementary curvature of the at least one of the outward-facing attachment structures of the inner frame, or both the curved longitudinal axis and the complementary curvature.

US Pat. No. 10,456,298

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Tear Film Innovations, In...

1. A device for treating a mammalian eye having an eyelid, comprising:a shield formed of a plate positionable proximate an inner surface of an eyelid, the shield including an energy-reflecting material that reflects light energy;
an energy transducer having a device that emits light energy, the energy transducer positionable outside of the eyelid when the shield is positioned proximate the inner surface of the eyelid, wherein the energy transducer provides light energy toward the energy-reflecting material at one or more wavelengths, including a first wavelength selected to at least partially pass through the eyelid to the shield and at least partially reflect back toward a target tissue region from the shield; and
an energy transmission surface positioned in a spaced relationship with the shield;
a housing, wherein the shield, the energy transducer, and the energy transmission surface are mechanically coupled to the housing;
an actuator coupled to the housing, wherein actuation of the actuator causes relative movement between the energy transmission surface and the shield so as to modify the spaced relationship;
wherein when the eyelid is positioned between the energy transducer and the shield, the light energy from the energy transducer passes through the eyelid and reflects off the shield.

US Pat. No. 10,456,297

SYSTEMS AND METHODS FOR SYNCHRONIZED THREE-DIMENSIONAL LASER INCISIONS

AMO Development, LLC, Sa...

1. An ophthalmic surgical laser system comprising:a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye;
an XY-scan device to deflect the pulsed laser beam;
a Z-scan device to modify a depth of a focus of the pulsed laser beam along an optical axis; and
a controller configured to synchronize an oscillation of the XY-scan device and an oscillation of the Z-scan device to form a three-dimensional laser tissue dissection, including to control the XY-scan device to move the focus of the laser beam in a plane perpendicular to the optical axis in an angular direction, which is a direction around the optical axis, from a first angular position to a second angular position once within a time interval while oscillating a radius of the focus, which is a distance from the optical axis, a first plurality of times within the same time interval, and to simultaneously control the Z-scan device to oscillate the depth of the focus a second plurality of times within the same time interval, wherein the first plurality of times is equal to the second plurality of times multiplied by two, three or four.

US Pat. No. 10,456,296

PATIENT INTERFACE FOR OPHTHALMOLOGIC DIAGNOSTIC AND INTERVENTIONAL PROCEDURES

OPTIMEDICA CORPORATION, ...

1. A method for intercoupling an ophthalmologic interventional system to an eye of a patient via a patient interface system, the patient interface system comprising a top portion and a bottom portion, the bottom portion having a hollow reservoir housing defining an interior volume and having proximal and distal ends, the top portion having proximal and distal ends and an optical element, the optical element occupying a portion of the interior volume defined by the hollow reservoir, the method comprising:a. removably and sealably coupling the distal end of the bottom portion to the eye of the patient;
b. mechanically interfacing the proximal end of the top portion with the interventional system;
c. coupling the top portion with the bottom portion while keeping an open access between the top portion and the bottom portion to provide access to the interior volume for transporting liquids or gases in or out of the interior volume;
d. forming a liquid layer within the interior volume above the eye; and
e. applying one or more loads to the liquid layer, such that the liquid layer is positioned within the interior volume and is located between the optical element and the eye.

US Pat. No. 10,456,295

MEDICAL DEVICE, ASSEMBLY AND METHOD FOR CREATING A CHANNEL IN SOFT TISSUE

TEL HASHOMER MEDICAL RESE...

1. A device for creating a channel having predetermined dimensions in an eye wall, the device comprising an elongated member extending along a longitudinal axis X between a first end and a second end;said first end comprising an engagement element configured for engagement with a grip unit comprising a rotor to cause rotation of said elongated member about said longitudinal axis X upon actuation of the rotor to create said channel;
said second end comprising a tissue piercing tip configured for piercing the eye wall during insertion of the device along said longitudinal axis X into the eye wall;
said elongated member comprising a segment proximal to the second end extending along said longitudinal axis X and configured for creating said channel by said rotation, said segment having an external surface having a circumference C and comprising:
at least one depression axially extending along at least a portion of said segment; and
one or more blades with a cutting edge, extending peripherally beyond said circumference C of said external surface, by a distance defining a cutting thickness, the one or more blades extending along at least part of said segment;
said device comprising a protective member configured and operable to:
be fixedly attached to the grip unit at a proximal end of the protective member,
have a lumen surrounding the elongated member and in which the elongated member is entered from its first end to be engaged by the engagement element with the grip unit,
have a predetermined length defining a length of the elongated member that penetrates the eye,
have a shape configured to penetrate through conjunctiva tissue of the eye wall and to form a stopper to prevent excessive penetration of the elongated member into sclera tissue of the eye wall and to block the device from penetrating the eye to an extent that causes damage to inside of the eye, and
be static during rotation of the elongated member thereby protecting the surrounding conjunctiva tissue during the channel creation in the eye wall.

US Pat. No. 10,456,294

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Tear Film Innovations, In...

1. A system for treating meibomian gland disease in at least a portion of an eyelid by a clinician, comprising:a back plate sized to be positioned between an eyeball and an eyelid of a patient;
a compressive element mechanically linked to the back plate, the compressive element positionable adjacent to the outer surface of the eyelid while the back plate of the treatment device is positioned between the eyeball and the eyelid, wherein the back plate and the compressive element collectively define an aperture between the back plate and the compressive element such that the aperture provides a line of sight that permits viewing of an eyelid margin by the clinician through the aperture when the back plate is positioned between an eyeball and an eyelid of a patient;
a light-emitting device that emits light energy, the light-emitting device positionable outside of the eyelid while the back plate is positioned between the eyeball and the eyelid, wherein the light-emitting device can emit light to heat tissue of the eyelid adjacent to the meibomian glands of the patient to a temperature sufficient to melt or soften meibum of the meibomian glands;
a housing, wherein the back plate, the light-emitting device, and the compressive element are mechanically coupled to the housing.

US Pat. No. 10,456,293

OPHTHALMIC SYSTEM FOR SUSTAINED RELEASE OF DRUG TO EYE

ForSight Vision5, Inc., ...

1. A method of manufacturing an ocular device configured to be positioned on a surface of the eye at least partially underneath at least one of the upper and lower eyelids and outside a cornea of the eye for delivering at least one therapeutic agent to an eye for an extended period of time, the method comprising:forming a support structure from a length of a first material having a first end region and a second end region into a first shape, wherein the first shape of the support structure provides an overall shape to the ocular device prior to positioning the ocular device on the surface of the eye;
dispersing at least one therapeutic agent into a second material creating a drug matrix, wherein the second material is different from the first material;
molding the drug matrix into a tubular structure having a lumen; and
threading the tubular structure over the length of the support structure such that the support structure extends through the lumen of the tubular structure,
wherein the first shape conforms to a second, different shape after positioning the ocular device onto the surface of the eye, and wherein upon being removed from the eye, the ocular device retains the second shape or changes to a third shape, wherein the third shape is different from both the first shape and the second shape.

US Pat. No. 10,456,292

COMPOSITIONS AND METHODS RELATING TO AN OCCLUSIVE POLYMER HYDROGEL

Revolution Contraceptives...

1. A hydrogel-forming solution comprising a polymer dissolved in a solvent, wherein the polymer is more than 75% comprised of styrene-alt-maleic acid and the solvent is DMSO, wherein the molecular weight of the polymer is within a range between 300 kDa and 800 kDa, and wherein the ratio of polymer to DMSO is within a weight/weight range from 15% to 40%.

US Pat. No. 10,456,291

METHOD OF PROFILE HEATSEALING

1. A method of conforming an overwrap to a pessary device, the method comprising:a. providing a pessary device comprising a longitudinal axis, a transverse axis, and an outer surface;
b. providing an overwrap material;
c. prior to contacting the overwrap material with a profile sealing tool, placing a portion of the overwrap material under tension;
d. placing the pessary device in contact with the overwrap material along a first side of the pessary device, and placing the pessary device in contact with the overwrap material along a second side of the pessary device opposing the first side, wherein the overwrap material covers at least a portion of the pessary device outer surface area;
e. contacting the overwrap material with the sealing tool, joining the overwrap material to itself and forming part of the final overwrap; and
f. removing the sealing tool.

US Pat. No. 10,456,289

METHOD AND DEVICE FOR THE MANAGEMENT OF BODY FLUIDS LEAKING FROM A SURGICAL DRAIN TUBE INCISION

ALDEN ADVANCED TECHNOLOGI...

1. A fluid collection system comprising:a baseplate having an adhesive backing configured to couple the baseplate to a patient's skin and defining a wafer having an approximately centrally positioned opening, and a ring shaped, radially-extending wafer connector coupled to said wafer and disposed around said opening configured to receive a first end of a surgical drain tube; and
an appliance including a leaked fluid remover, said leaked fluid remover having a fluid remover connector operable to detachably couple with the wafer connector, the leaked fluid remover connector including a first housing element and a second housing element received by said first housing element and a spacer having an upper surface and a lower surface, the first housing element including an outer septum having a lower surface positioned on or coupled to the upper surface of the spacer, and the second housing element including an inner septum positioned on or coupled to the lower surface of the spacer; and
a leaked fluid collector having an outer film and an inner film, the outer film coupled to an upper portion of the first housing component and the inner film coupled to a lower portion of the first housing component thereby coupling an interior of the leaked fluid collector to the fluid remover connector, wherein coupling of the fluid remover connector to the wafer connector forms a fluid flow chamber therebetween through which leaked fluid from the incision flows through the fluid flow chamber and into the leaked fluid collector.

US Pat. No. 10,456,288

RAIL SYSTEM, FUNCTIONAL COMPONENT, AND ADAPTER ELEMENT

1. An orthopedic rail system, comprising:a first component with a receiving element;
a second component with a connection end for connecting to the receiving element;
wherein
the receiving element has two stop walls lying opposite each other;
the connection end has two lateral walls lying opposite each other;
the receiving element and the connection end are connectable to each other by at least one connection element, such that the lateral walls bear on the stop walls in the connected state;
the stop walls and the lateral walls, respectively, taper conically toward each other; and
the receiving element and the connection end are able to be positioned steplessly relative to each other.

US Pat. No. 10,456,287

THERAPEUTIC SOCK

1. A therapeutic sock comprising;a sock body formed in a tubular shape and terminating in a closed toe portion, the toe portion being divided into a first compartment configured to accommodate a big toe and four additional compartments for other toes,
wherein the sock is formed from a knit material, and
wherein each of the four additional compartments has an area of increased compression as compared to a compression in other areas of the sock, the area of increased compression having threads formed of a different material than a material of the rest of the sock,
wherein the area of increased compression extends laterally around a circumference of each of the additional compartments and extends only around a proximal portion of the additional compartments to such a length that the area of increased compression provides compression pressure on extensor and flexor tendons of the toes, wherein a distal portion of the additional compartments does not have an area of increased compression,
wherein the threads formed of different material contain a material selected from the group consisting of copper and ceramic powder, and
wherein there is an additional area of increased compression extending longitudinally along a medial edge of the sock, in a region of the first compartment.

US Pat. No. 10,456,286

TORQUE-COMPENSATING ASSISTIVE WRIST BRACES

The Regents of the Univer...

1. A torque-compensating assistive wrist brace comprising:a hand member adapted to attach to a user's hand, the hand member comprising a continuous band having a relative wide finger passage through which the user's fingers can pass and a smaller thumb passage through which the user's thumb can pass;
a forearm member adapted to attach to the user's forearm, the forearm member including a body and mounting elements provided on the body that form pivot points of the wrist brace; and
an assistive linkage that connects the hand and forearm members together, the assistive linkage comprising one or more spring-assisted six-bar linkages and a transverse shaft, each spring-assisted six-bar linkage provided on a lateral side of the wrist brace, each spring-assisted six-bar linkage including four binary links, two ternary links, and a biasing element that together apply a balancing torque to a wrist of the user that counteracts intrinsic stiffness within the wrist and assists the user in rotating the wrist in both the flexion and extension directions;
wherein the mounting elements comprise a first pair of laterally spaced mounting arms that extend from a distal end of the body of the forearm member on opposed lateral sides of the body;
wherein the mounting elements further comprise a top mounting element that includes a central longitudinal flange that extends upward from the body and a second pair of laterally spaced mounting arms that extend laterally from the longitudinal flange and then forward toward the distal end of the body;
wherein the mounting arms each include an opening that defines a location of a pivot point for links of the one or more spring-assisted six-bar linkages, and wherein the central longitudinal flange includes an opening adapted to receive the transverse shaft upon which links of the one or more spring-assisted six-bar linkages are mounted;
wherein a first binary link of each spring-assisted six-bar linkage is fixedly attached to a lateral side of the hand member, pivotally connected to one of the mounting elements of the forearm member, and pivotally connected to a first ternary link of the corresponding spring-assisted six-bar linkage.

US Pat. No. 10,456,285

SPLIT SHEATH DEPLOYMENT SYSTEM

Cook Medical Technologies...

1. A method of deploying a radially expandable prosthesis using a delivery and deployment device, the delivery and deployment device comprising a proximal release mechanism for releasably retaining a proximal portion of the prosthesis and having a first resistance, a distal release mechanism for releasably retaining a distal portion of the prosthesis and having a second resistance, and a biasing compensator for regulating the relationship between the first resistance and the second resistance, the method comprising the steps of:positioning the delivery and deployment device so that the prosthesis is adjacent an area to be treated; and
actuating the proximal and distal release mechanisms in a single coordinated movement so that the proximal release mechanism releases the proximal portion of the prosthesis and the distal release mechanism releases the distal portion of the prosthesis in a predetermined manner.

US Pat. No. 10,456,284

DEPLOYMENT HANDLE FOR A PROSTHESIS DELIVERY DEVICE

Cook Medical Technologies...

1. A handle assembly for a prosthesis delivery device, the handle assembly comprising:an axially slidable handle comprising a housing and a slidable and retractable sheath attached to and extending from a distal end of the housing;
a fixed handle proximal of the axially slidable handle that is fixed relative to the delivery system and comprising a housing having a distal end and a proximal end, and a fixed handle locking mechanism;
a rotatable handle proximal of the fixed handle that is rotatable relative to the delivery system and comprising:
a housing having a distal end and a proximal end;
a rotatable handle locking mechanism preventing rotation of the rotatable handle;
a prosthesis proximal end release mechanism disposed in the housing of the rotatable handle and releasably and operatively connected to a proximal end of a prosthesis;
a prosthesis distal end release mechanism disposed in the housing of the rotatable handle and releasably and operatively connected to a distal end of a prosthesis;
wherein the slidable handle is slidable in a proximal direction to proximally retract the sheath from over the prosthesis;
wherein unlocking of the rotatable handle locking mechanism permits a first rotation of the rotatable handle to release the proximal end of the prosthesis from the delivery system;
wherein a subsequent unlocking of the fixed handle locking mechanism permits a second rotation of the rotatable handle to release the distal end of the prosthesis from the delivery system;
wherein the distal end of the prosthesis cannot be released from the delivery system until the proximal end of the prosthesis is released from the delivery system; and
wherein the fixed handle locking mechanism cannot be unlocked until the rotatable handle locking mechanism is unlocked.

US Pat. No. 10,456,283

APPARATUS AND METHOD FOR MAINTAINING PATENCY IN A VESSEL ADJACENT TO NEARBY SURGERY

BOSTON SCIENTIFIC SCIMED,...

1. A method of preserving patency in a non-occluded coronary artery during nearby surgery comprising:advancing a steerable delivery catheter having a retrievable patency maintaining element contained therein in a first compact configuration into a non-occluded coronary artery within a patient within which coronary artery patency is to be preserved;
deploying the retrievable patency maintaining element in the non-occluded coronary artery;
withdrawing the steerable delivery catheter a predetermined distance from the non-occluded coronary artery within which patency is to be preserved;
performing surgery nearby the non-occluded coronary artery within which patency is to be preserved;
retrieving the retrievable patency maintaining element from the non-occluded coronary artery using a retrieval mechanism for the retrievable patency maintaining element;
removing the retrieval mechanism for the retrievable patency maintaining element from the patient wherein the withdrawing step further includes maintaining a connection between the retrievable patency maintaining element and the steerable delivery catheter or a retrieval mechanism; wherein maintaining a connection between the retrievable patency maintaining element and the steerable delivery catheter or a retrieval mechanism is through at least one of a tether, an activation link, and an inflation tube; and wherein the inflation tube includes a valve adapted to control flow of a fluid during inflation, an implantation interval, and/or deflation of the retrievable patency maintaining element.

US Pat. No. 10,456,282

DELIVERY SYSTEM FOR ANCHOR AND METHOD

MEDTRONIC VASCULAR, INC.,...

1. A delivery system comprising:an inner member comprising:
a main shaft; and
an anchor guide tip at a distal end of the main shaft, wherein the anchor guide tip comprises an anchor guide lumen extending from the main shaft through the anchor guide tip to a distal surface of the anchor guide tip; and
a helical anchor around the main shaft and within the anchor guide lumen, a distal portion of the helical anchor being superelastically deformed by the anchor guide lumen to be parallel to a longitudinal axis of the anchor guide tip.

US Pat. No. 10,456,281

STENT HAVING FLEXIBLY CONNECTED ADJACENT STENT ELEMENTS

1. A method of stenting vasculature of a patient, the method comprising:delivering an implantable stent to a target site for treatment in the vasculature of a patient, the implantable stent defining a length and having a deployed diameter suitable for implantation and a compacted diameter suitable for passage of the stent through a body conduit, the implantable stent comprising adjacent metallic stent elements spaced apart longitudinally which are connected longitudinally by a polymeric cover; and
expanding the implantable stent from the compacted diameter to the deployed diameter to stent the vasculature of the patient at the target site, the deployed diameter including the cover having a multiplicity of individual apertures each having a minimum size of about 0.10 mm such that the implantable stent has a porosity index of at least 50% along the length of the implantable stent at the deployed diameter;
wherein the adjacent metallic stent elements that are spaced apart longitudinally are connected longitudinally only by the polymeric cover.

US Pat. No. 10,456,280

SYSTEMS AND METHODS OF USING A BRAIDED IMPLANT

DePuy Synthes Products, I...

1. A system for treating an aneurysm, comprising:a plurality of braided implants, wherein each braided implant comprises a porosity of 65%-70% that is consistent over a different 1 mm diameter range in a diameter of a vessel, each braided implant configured to provide the consistent porosity over different 1 mm diameter ranges.

US Pat. No. 10,456,279

STENT FOR BIFURCATION, A SYSTEM FOR INTRAVASCULAR IMPLANTATION OF THE STENT FOR BIFURCATION AND A METHOD OF IMPLANTATION OF THE STENT FOR BIFURCATION

BALTON SP. Z O.O., (PL)

1. A method of introducing and positioning a stent for bifurcation by an intravascular implantation system including:a stent, an external tube, an internal tube marked with a ring visible on an X-ray image, and a profiled balloon;
the profiled balloon comprises a proximal part fastened to an external surface of the external tube, and a distal part fastened to an external surface of the internal tube, the proximal part of greater diameter than the distal part, and a medial part having length of 0.5 to 8 mm and located between the distal part and the proximal part,
wherein the distal part, the proximal part and the medial part of the profiled balloon are non-separable;
the stent comprising a distal cylindrical part, a proximal cylindrical part of greater diameter than the distal part, and two longitudinal connectors connecting the distal part and the proximal part of the stent; and
the two longitudinal connectors arranged on opposite sides of the stent and having lengths of 0.5 to 8 mm and forming a cell of the stent with a surface area enlarged compared with the surface area of the distal cylindrical part, the two longitudinal connectors having a curvilinear shape and clamped on the profiled balloon in a detachable way,
wherein a position of the ring coincides with the proximal edge of the distal part of the stent clamped on the profiled balloon,
wherein upon clamping the stent in a separable way on the profiled balloon, the cell encompasses the medial part of the profiled balloon, the method comprising:
introducing a guide wire to a main branch of a vessel at a bifurcation site;
introducing at the bifurcation site the system including the stent,
wherein the ring signifies a position of edges of the proximal distal part of the stent clamped on the balloon being positioned precisely at a groin of a vessel, so that the distal part of the stent is situated behind a fork of the vessel, in the main branch, the proximal part of the stent is situated before the fork of an artery, and the medial part of the stent, with the cell of the stent positioned in a lumen of the lateral branch of the vessel; and then
when fluid under pressure of 6 to 20 atm is introduced to the profiled balloon, implanting the stent;
removing the fluid from the profiled balloon; and
withdrawing the system and the guide wire.

US Pat. No. 10,456,278

INTERCONNECTION BETWEEN SELECTIVELY-EXPANDABLE AND SELF-EXPANDABLE SECTIONS OF AN OSTIAL STENT

Medical Ingenuities, LLC,...

1. An ostial stent for placement at the ostium of a patient's vascular system so as to improve vessel patency in the ostial region, said ostial stent comprising:a stent tube presenting spaced apart proximal and distal stent openings and a longitudinal stent passage that extends between the openings,
said stent tube including a selectively-expandable tube section and a self-expandable tube section,
said self-expandable tube section projecting longitudinally from one of the stent openings, and being automatically expandable to a flared condition for placement within the ostium,
said tube sections being arranged in an end-to-end to configuration to define a connection location spaced between the stent openings; and
a weldable stent connection structure interconnecting the tube sections at the connection location,
said stent connection structure spanning between the tube sections and being formed of a material dissimilar from that of the tube sections.

US Pat. No. 10,456,277

PERCUTANEOUS HEART VALVE

Edwards Lifesciences Card...

1. A method of deploying a percutaneous heart valve into a body cavity having an opening surrounded by surrounding body tissue, the method comprising:delivering a percutaneous heart valve to the body cavity in a collapsed configuration, the percutaneous heart valve comprising:
an expandable frame comprising a proximal end and a distal end and a longitudinal axis extending therethrough, the expandable frame comprising a plurality of cells configured to permit the frame to radially expand and collapse between the collapsed configuration and an expanded configuration;
a valve seated inside the expandable frame;
a proximal anchoring portion; and
a distal anchoring portion comprising a plurality of distal anchors; and
radially expanding the expandable frame to the expanded configuration within the opening, wherein, when the percutaneous heart valve is in the expanded configuration:
the proximal anchoring portion extends at least partially distally;
at least a portion of each distal anchor extends proximally to a proximalmost portion of the distal anchor positioned radially outward from the frame, the proximalmost portions extending in a direction that is more parallel with the longitudinal axis than with a transverse axis perpendicular to the longitudinal axis;
at least one of the plurality of distal anchors bends radially outwardly before bending to extend toward the proximal anchoring portion; and
the proximalmost portions of the plurality of distal anchors are spaced apart by less than two cell lengths from a distalmost portion of the proximal anchoring portion;
wherein radially expanding the expandable frame draws the proximal anchoring portion and the plurality of distal anchors closer together with the surrounding body tissue positioned between the proximal anchoring portion and the plurality of distal anchors.

US Pat. No. 10,456,276

MEDICAL DEVICE SUITABLE FOR LOCATION IN A BODY LUMEN

Veryan Medical Limited, ...

1. A stent suitable for deployment in a blood vessel, wherein the stent is expandable from a delivery configuration to an expanded deployed configuration, wherein upon application of a load to the stent when the stent is in the expanded deployed configuration the stent is movable from an unloaded expanded deployed configuration to a loaded expanded deployed configuration, wherein in the unloaded expanded deployed configuration the longitudinal axis of the stent is straight; and wherein in the loaded expanded deployed configuration the longitudinal axis of the stent is curved in three-dimensional space, such that the stent can cause at least a part of a longitudinal axis of a blood vessel in which it is deployed to curve in three-dimensional space, the stent comprising a plurality of spaced annular elements connected to each other by primary connecting elements and secondary connecting elements wherein the primary and secondary connecting elements are different from each other in at least one of a radial dimension, a circumferential dimension, a length, a width, a thickness, a geometry, a stiffness and a material used to form the primary and secondary connecting elements such difference biasing the stent to achieve the three-dimensional curvature during loading while the stent moves from the unloaded deployed expanded configuration to the loaded deployed expanded configuration.

US Pat. No. 10,456,275

ANCHORING SYSTEM FOR PROSTHETIC AND ORTHOTIC DEVICES

SHRINERS HOSPITAL FOR CHI...

1. An anchoring system comprising:(i) a fastener including a substantially planar base, and a first clasp-engaging member protruding perpendicularly from the portion of the base to define an axis of rotation and having an outwardly-extending flange, the fastener further including an adhesive suitable to secure the base directly to the skin of a wearer, and
(ii) a clasp having a first end configured to engage and rotate about the axis of rotation defined by the first clasp-engaging member and a second end configured to engage a cable of a prosthetic or orthotic device, wherein the fastener and clasp are configured to facilitate manual operation of the cable of the prosthetic or orthotic device when the clasp is engaged with the fastener, the adhesive having a sufficient strength to remain adhered to the skin during manual operation of the prosthetic or orthotic device.

US Pat. No. 10,456,274

METHOD AND APPARATUS FOR PERFORMING ANTERIOR HIP SURGERY

1. An apparatus for establishing a supine pelvic reference plane for a specific patient, the apparatus comprising:an elongated support arm;
a first leg attached to the elongated support arm;
a second leg slidably attached to the elongated support arm, wherein the second leg slides along the elongated support arm; and
a third leg slidably attached to the elongated support arm, wherein the third leg slides along the elongated support arm, and wherein;
the first, second, and third legs have tips,
the first leg is closer to one end of the elongated support arm than the second leg and the third leg; and
the second and third legs are slidably adjusted relative to the elongated support arm such that:
the tip of the first leg is configured to contact a left anterior superior iliac spine of the specific patient,
the tip of the second leg is configured to contact a right anterior superior iliac spine of the specific patient, and
the tip of the third leg is configured to contact an anterior aspect of an ischium of a pelvis of the specific patient below an acetabulum, and further wherein
the apparatus defines the supine pelvic reference plane for the specific patient, and
the supine pelvic reference plane has a known relationship to a standard reference plane for the specific patient.

US Pat. No. 10,456,273

SURGICAL CUT VALIDATION TOOL AND METHOD

1. A surgical cut validation tool for validating a cut in a bone, the cut defining a nominal section to be removed from the bone having at least one nominal cut surface, the cut further defining a remaining bone having at least one cut surface created when the nominal section is removed, the surgical cut validation tool comprising:a body having
at least one planar remaining bone contacting surface, and
an outer surface extending from the at least one planar remaining bone contacting surface, the outer surface including a border surface portion extending from and adjacent to a junction between the outer surface and each one of the at least one planar remaining bone contacting surface;
wherein each one of the at least one planar remaining bone contacting surface matches a respective one of the at least one nominal cut surface of the nominal section, and each one of the at least one planar remaining bone contacting surface conforms to a corresponding one of the at least one cut surface of the remaining bone created when the nominal section is removed and is superposable against the corresponding one of the at least one cut surface of the remaining bone in a predetermined configuration; and
at least part of the border surface portion has a shape matching a shape of a corresponding part of an outer surface of the nominal section, the at least part of the border surface portion having a same relative position with respect to each one of the at least one planar remaining bone contacting surface than the part of the outer surface of the nominal section with respect to a corresponding one of the at least one nominal cut surface of the nominal section, said at least part of the border surface portion being shaped to be substantially aligned with an outer surface of the remaining bone adjacent to a junction of the at least one cut surface of the remaining bone when the body is superposed to the remaining bone in the predetermined configuration; and
wherein only the at least one planar remaining bone contacting surface contacts the remaining bone.

US Pat. No. 10,456,272

UNICOMPARTMENTAL KNEE ARTHROPLASTY

ENGAGE UNI LLC, Orlando,...

1. A system comprising:a tibial tray comprising a body having a joint-facing side and an opposite bone-facing side, wherein a ridge protrudes from and extends across the bone-facing side, wherein an undercut channel extends across the bone-facing side within the ridge;
a tibial drill guide comprising a body and a shaft, wherein the tibial drill guide body corresponds to the tibial tray body, wherein the shaft is coupled to the tibial drill guide body, wherein a hole extends through the tibial drill guide along the shaft; and
a reamer comprising a distal cutting section, wherein the distal cutting section is received in the hole;
wherein, when the distal cutting section is inserted into the hole and advanced to be adjacent to the tibial drill guide body, a first portion of the distal cutting section is exposed on a bone-facing side of the tibial drill guide body and protrudes outwardly from the bone-facing side of the tibial drill guide body.

US Pat. No. 10,456,271

PROSTHESIS REVISION SYSTEMS AND METHODS

1. An extraction device for a prosthesis disposed in a bone having an exposed portion, comprising: a controller including a trigger; a support having a proximal end and a distal end opposite of said proximal end, said support further having a longitudinal axis extending from said proximal end to said distal end with said proximal end coupled to said controller, said support further having an adapter coupled to said distal end with said adapter configured to engage the exposed portion of the prosthesis; and an oscillator coupled to said controller and to said support, said oscillator configured to control a series of vibratory pulses having an oscillation frequency and an oscillation magnitude of said support with said oscillation frequency and said oscillation magnitude configured to extract the prosthesis responsive to said series of vibratory pulses without impact forces; and a mechanical frame having a C-portion, said mechanical frame including said adaptor wherein said C-portion includes a pair of lateral legs coupled to opposing ends of a longitudinal leg with said longitudinal leg generally parallel to an extraction axis of the prosthesis, wherein one of said lateral legs includes an inner surface including an extraction coupler mechanically communicated to said oscillator.

US Pat. No. 10,456,270

ANTERIOR HIP EXTRACTOR

Shukla Medical, St. Pete...

1. An implant extraction device comprising:an arcuate frame that includes:
a distal end having a recess for receiving an adapter, and
a proximal end having:
a first aperture for receiving an implant, the first aperture having a longitudinal axis that is oriented about 40 to 50 degrees relative to a longitudinal axis of the recess and
a second aperture adjacent the first aperture for receiving a fastener.

US Pat. No. 10,456,269

INTERVERTEBRAL IMPLANT

Globus Medical, Inc., Au...

1. A method for positioning an intervertebral implant in a treated area of an intervertebral space between vertebral bodies of a spine, said method comprising:inserting the implant in the intervertebral space, wherein the implant comprises:
a spacer having an inferior and superior surface, wherein the inferior and superior surfaces each have a contact area capable of engaging with anatomy in the treated area, and the inferior and superior surfaces define a graft window extending from the superior surface of the spacer to the inferior surface of the spacer;
a first hole extending from an anterior surface to the inferior surface of the spacer;
a second hole extending from the anterior surface to the superior surface of the spacer;
a plate coupled to the spacer, wherein the plate includes holes for receiving fasteners; and
a screw back out prevention mechanism positioned within a recess of the plate and configured to prevent the fasteners from backing out of the holes,
wherein the screw back out prevention mechanism includes a pin screw and a nut, wherein the nut is configured to be positioned entirely within the graft window of the spacer, and wherein the graft window is configured to receive bone graft to enhance fusion between adjacent vertebrae.

US Pat. No. 10,456,268

SYSTEM OF SPINAL ARTHODESIS IMPLANTS

LDR Medical, S.A.S., Sai...

1. A system for arthrodesis of a first vertebra and a second vertebra adjacent to the first vertebra comprising:an intersomatic cage and a cage anchor;
an interspinous implant comprising a body, a plurality of foldable wings movable with respect to the body and an insert coupled to one end of each foldable wing of the plurality of foldable wings, the insert linearly advanceable within the body to extend the plurality of foldable wings from a storage position within the body to a deployed position outside the body; and
a facet screw having a longitudinal axis between a free end and a head, the screw comprising an internal conduit along at least a portion of the longitudinal axis and a plurality of windows extending from an exterior surface of the screw into the conduit.

US Pat. No. 10,456,267

LATERAL CAGE STABILIZATION

Medos International Sarl,...

1. A kit for stabilizing an intervertebral disc space, comprising:a) an intervertebral fusion cage having an anterior face, an upper surface and a lower surface,
b) an expulsion barrier comprising:
i) a plurality of suture anchors, each suture anchor having a hollow shaft having an inside surface forming a bore, a proximal end, a distal end, and an outside surface having a bone-engaging surface feature thereon, and
ii) a suture having a first end portion and a second end portion,
wherein the suture is threaded through the bore of each suture anchor, and
wherein the end portions of the suture contact each other to form only a single a slip-knot,
wherein each suture anchor has a longitudinal axis extending in the direction defined by the proximal end of the suture anchor and the distal end of the suture anchor, and
wherein the bore extends substantially in parallel with the longitudinal axis of the suture anchor, from the proximal end of the suture anchor to the distal end of the suture anchor,
wherein the plurality of suture anchors define a plurality of suture segments in the suture, and
wherein the expulsion barrier is disposed with respect to the cage such that each suture segment traverses the anterior face of the cage so that each suture segment passes above the upper surface of the cage and below the lower surface of the cage.

US Pat. No. 10,456,265

FIXATION MECHANISM FOR AN IMPLANT

WRIGHT MEDICAL TECHNOLOGY...

1. An ankle prosthesis, comprising:a tibial component configured for attachment to a tibia of a person; and
a talar component having a first surface configured for facing the tibial component and a second surface configured for facing a talus of the person, the second surface having first and second arms attached thereto, for pivoting or flexing outwardly in medial and lateral directions, respectively, to engage side surfaces of a previously formed slot in the talus; and
a separator comprising at least one of a cone and a wedge, the separator being positioned between the first and second arms and attached to a threaded member for moving the separator in an anterior-posterior direction, the separator configured to be advanced towards an end of each of the first and second arms attached to the second surface, for causing the first and second arms to pivot or flex outwardly.

US Pat. No. 10,456,264

HUMERAL IMPLANT ANCHOR SYSTEM

Tornier, Inc., Bloomingt...

1. A stemless humeral shoulder assembly, comprising:a base member comprising a distal end configured to be embedded in bone and a proximal end to be disposed at a bone surface, the base member having a plurality of spaced apart arms projecting from the proximal end to the distal end, each arm having an inner edge and an outer edge radially outward of the inner edge;
an anchor adapted to be assembled with the base member to a position disposed within the arms, the anchor configured to project circumferentially both in engagement with the base member and into a space circumferentially between the arms and radially outward beyond the inner edges of the arms, the anchor being exposed between the arms when the anchor is assembled with the base member; and
a recess being surrounded by the base member and the anchor and projecting distally from a proximal end of the anchor and through a distal end of the anchor, the recess configured to receive a mounting member of an anatomical or reverse joint interface,
wherein each arm comprises a first flat face and a second flat face opposite the first flat face, the first and second flat faces being separated by a thickness, each of the first and second flat faces extending from the proximal end of the base member toward the distal end of the base member, each of the first and second flat faces having a width measured in a radial direction, the thickness having a width dimension measured in a circumferential direction, the width of each of the first and second flat faces being greater than the width of the thickness.

US Pat. No. 10,456,263

PATIENT-ADAPTED AND IMPROVED ARTICULAR IMPLANTS, DESIGNS AND RELATED GUIDE TOOLS

ConforMIS, Inc., Billeri...

1. A femoral implant for replacing a knee joint of a patient comprising:a. a medial condyle having a medial articular surface that includes a medial sagittal curve derived from a corresponding medial condyle of the knee joint of the patient;
b. a lateral condyle having a lateral articular surface that includes a lateral sagittal curve derived from a corresponding lateral condyle of the knee joint of the patient; and
c. a trochlear portion having a trochlear articular surface that includes a trochlear sagittal curve derived from the trochlear region of the knee joint of the patient; and
d. one or more additional implant features or measurements including one or more planar facets on the bone-facing surface of the femoral implant being derived from patient-specific data and a weighting of at least one parameter including preservation of bone,
wherein the medial, lateral and trochlear sagittal curves are substantially J-curves derived from the corresponding, respective medial, lateral and trochlear J-curves of the knee joint of patient.

US Pat. No. 10,456,262

PATIENT-SPECIFIC IMPLANT FLANGES WITH BONE SIDE POROUS RIDGES

Howmedica Osteonics Corp....

1. An implant comprising:a base defining a dome and a circumferential rim;
an elongated flange extending outwardly from the base, at least a first portion of the flange defining a plane and having opposing flat surfaces; and
a ridge extending from the first portion of the flange in a direction transverse to the plane and including opposing concave and convex surfaces, wherein a hole extends through the flange and the ridge and is configured for receipt of a portion of a fastener having a head and a shank, wherein the convex surface of the ridge is a bone-contacting surface, and wherein the concave surface of the ridge is configured for receipt of the head of the fastener.

US Pat. No. 10,456,261

DEVICES, SYSTEMS AND METHODS FOR MANUFACTURING ORTHOPEDIC IMPLANTS

ConforMIS, Inc., Billeri...

1. A fixture for use in manufacturing a surgical implant for treating a portion of a bone of a patient, the fixture comprising:an outer surface, the outer surface including:
an engagement portion configured to engage a patient-specific portion of the implant in a known orientation during at least a portion of the manufacturing of the implant; and
a connecting portion, the connecting portion configured for releasably connecting to one or more processing apparatuses in a predetermined orientation,
wherein the engagement portion includes first and second holes, the first and second holes sized and positioned to accommodate first and second pegs, respectively, extending from the implant when the implant is engaged with the engagement portion in the known orientation.

US Pat. No. 10,456,260

METHODS FOR ACCESSING A LEFT VENTRICLE

Trans Cardiac Therapeutic...

1. A method for tensioning a mitral valve in a patient's heart, said method comprising:forming a passageway through an apical wall into a left ventricle of the heart;
attaching a distal end of an artificial chordae to free ends of the leaflets of the mitral valve;
securing a proximal end of the artificial chordae near or in the passageway, wherein the artificial chordae is sufficiently taut to position the leaflets to better seal the leaflets and minimize leakage through the mitral valve.

US Pat. No. 10,456,259

TRANSVALVULAR INTRAANNULAR BAND FOR MITRAL VALVE REPAIR

Heart Repair Technologies...

1. A transvalvular intraannular band, the transvalvular band comprising:an elongate body having a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion connected to the first end and the second end, wherein the central portion comprises a convex arcuate shape and comprises a plurality of crossing struts encapsulated by a material such that the plurality of crossing struts are fixed relative to each other, the crossing struts intersecting at an intersection zone, the central portion configured to be displaced transversely from an intraannular plane when the band is attached to an annulus; wherein the first end and the second end are configured to be attached to the annulus within the intraannular plane and the central portion is configured to be convex in a direction of outflow to support valve leaflets at a point displaced toward a ventricle from the intraannular plane, wherein the first end and the second end reside on a septal-lateral axis transverse to coaptive edges of the valve leaflets when the band is attached to the annulus, and wherein the band does not comprise an annuloplasty ring.

US Pat. No. 10,456,258

TISSUE SHAPING DEVICE

Cardiac Dimensions Pty. L...

1. A method of performing mitral valve annuloplasty on a patient's heart comprising:percutaneously delivering a mitral valve device to a coronary sinus in a collapsed delivery configuration within a catheter, the mitral valve device comprising a first expandable anchor, a second expandable anchor, and an elongate body extending therebetween, the elongate body defining a longitudinal axis of the mitral valve device;
deploying the first expandable anchor from the catheter;
expanding the first expandable anchor in the coronary sinus;
anchoring the first expandable anchor in an anchored configuration in the coronary sinus, wherein in the anchored configuration the first expandable anchor comprises a flexible elongate member and a securing member for securing a first and second end of the flexible elongate member therein at a distal end of the securing member, the securing member generally aligned with the elongate body along the longitudinal axis, a first segment of the flexible elongate member extending from a distal end of the first expandable anchor to a proximal end of the first expandable anchor to engage the elongate body proximal a distal end of the elongate body, and a second segment of the flexible elongate member extending from where the first segment engages the elongate body to the distal end of the first expandable anchor, the first segment crossing the second segment between the distal and proximal ends of the first expandable anchor; and
anchoring the second expandable anchor in the coronary sinus.

US Pat. No. 10,456,257

TISSUE SHAPING DEVICE

Cardiac Dimensions Pty. L...

1. A mitral valve therapy device configured for deployment within a coronary sinus, the therapy device comprising an expandable distal anchor, a proximal anchor, and an elongate body extending therebetween, the elongate body defining a longitudinal axis of the therapy device, the expandable distal anchor comprising:a flexible elongate member and a securing member for securing a first and second end of the flexible elongate member therein at a distal end of the securing member, the securing member generally aligned with the elongate body along the longitudinal axis, a first segment of the flexible elongate member extending from a distal end of the distal anchor to a proximal end of the distal anchor to engage the elongate body proximal the distal end of the elongate body, and a second segment of the flexible elongate member extending from where the first segment engages the elongate body to the distal end of the distal anchor, the first segment crossing the second segment at a location between the distal and proximal ends of the distal anchor, the distal anchor further having a collapsed configuration for delivery into the coronary sinus within a catheter and an expanded configuration for anchoring the distal anchor in the coronary sinus, the location being positioned radially outward from the securing member when the distal anchor is in the expanded configuration.

US Pat. No. 10,456,256

HEART VALVE REPAIR

St. Jude Medical, Cardiol...

1. A device for repairing a native heart valve, comprising:an inflatable, collapsible and expandable, and continuously toroidal-shaped body having an inner perimeter and an outer perimeter, the inner perimeter defining an unobstructed opening and the outer perimeter being capable of matching a perimeter of the native heart valve, the body being configured to couple to at least a portion of the annulus of the native heart valve to remodel a geometry of the native heart valve;
a plurality of flexible coils extending from the body for coupling the body to the native heart valve; and
a plurality of hooks extending from an underside of the body for coupling the body to native valve leaflets.

US Pat. No. 10,456,255

DISK-BASED VALVE APPARATUS AND METHOD FOR THE TREATMENT OF VALVE DYSFUNCTION

Cephea Valve Technologies...

1. A method of deploying a prosthetic cardiac valve in a patient, the method comprising:inserting the prosthetic cardiac valve in a collapsed configuration within a dysfunctional mitral valve in the patient's heart, the prosthetic cardiac valve including a distal portion, a proximal portion, and a central portion therebetween;
permitting the distal portion to self-expand such that the distal portion flares radially outward relative to the collapsed configuration and relative to the central portion, the flared distal portion forming a distal disk having a convex annular shape such that the distal disk points distally;
pulling the distal disk proximally into a plane of the dysfunctional mitral valve;
engaging mitral valve tissue with a plurality of hooks disposed on the distal disk proximal to a distal end of the prosthetic cardiac valve;
permitting the proximal portion to self-expand on an opposite side of the dysfunctional mitral valve such that the proximal portion flares radially outward relative to the collapsed configuration and relative to the central portion, the flared proximal portion forming a proximal disk, wherein pulling the distal disk proximally occurs prior in time to permitting the proximal portion to self-expand; and
permitting the central portion of the valve anchor to self-expand within the dysfunctional mitral valve to move the distal and proximal disks toward each other to compress the dysfunctional mitral valve.

US Pat. No. 10,456,254

TRANSCATHETER PROSTHETIC HEART VALVE DELIVERY SYSTEM WITH RECAPTURING FEATURE AND METHOD

Medtronic, Inc., Minneap...

1. A method of recapturing a deployed stented prosthetic heart valve at an implantation site, the method comprising:receiving a delivery system loaded with a radially expandable prosthetic heart valve having a frame to which a valve structure is attached, the delivery system comprising an outer sheath over an inner sheath, the inner sheath containing the prosthetic heart valve in a compressed arrangement over an inner shaft assembly in a loaded state of the delivery system;
delivering the prosthetic heart valve in the compressed arrangement through a bodily lumen of a patient and to the implantation site via the delivery system in the loaded state;
proximally retracting the inner sheath relative to the prosthetic heart valve such that a distal region of the prosthetic heart valve is exposed distal the inner sheath, wherein the distal region self-expands toward a deployed arrangement;
evaluating a position of the prosthetic heart valve relative to the implantation site;
distally advancing the outer sheath relative to the prosthetic heart valve such that the outer sheath is arranged over the prosthetic heart valve to cause the distal region of the prosthetic heart valve to transition toward a collapsed arrangement to recapture the prosthetic heart valve within the outer sheath, and
proximally advancing the inner shaft assembly simultaneously with distally advancing the outer sheath to position the outer sheath over the distal region of the prosthetic heart valve to transition toward the collapsed arrangement to recapture the prosthetic heart valve within the outer sheath.

US Pat. No. 10,456,253

LOW PROFILE DELIVERY SYSTEM FOR TRANSCATHETER HEART VALVE

Edwards Lifesciences Corp...

1. An apparatus for delivering a prosthetic valve through the vasculature of a patient comprising:a steerable guide catheter having a handle portion and an elongated guide tube extending from the handle portion, the elongated guide tube having a distal end portion comprising a steerable section, the guide catheter further comprising a first adjustment mechanism on the handle portion and a pull wire operatively connecting the first adjustment mechanism to the steerable section for changing the curvature of the steerable section via manual adjustment of the first adjustment mechanism, the guide catheter further comprising a second adjustment mechanism coupled to the handle portion; and
a balloon catheter sized to slidably extend through the guide catheter, the balloon catheter comprising an elongated shaft extending coaxially through the guide tube and the handle portion, the shaft comprising a proximal end portion and a distal end portion, the balloon catheter further comprising an inflatable balloon mounted on the distal end portion of the shaft;
wherein the second adjustment mechanism comprises a rotatable component, wherein rotation of the rotatable component causes the shaft of the balloon catheter and the inflatable balloon to move longitudinally relative to the guide tube and the handle portion while the guide tube remains stationary upon rotation of the rotatable component;
wherein the second adjustment mechanism comprises a securement mechanism configured to selectively retain the shaft of the balloon catheter to prevent longitudinal sliding movement of the shaft relative to the second adjustment mechanism and release the shaft to permit longitudinal sliding movement of the shaft relative to the second adjustment mechanism and the guide tube without rotation of the rotatable component of the second adjustment mechanism.

US Pat. No. 10,456,251

SURGICAL METHODS OF REPLACING PROSTHETIC HEART VALVES

Edwards Lifesciences Corp...

1. A surgical method of implanting a two-stage prosthetic heart valve in a native heart valve annulus of a patient, comprising:providing an expandable anchoring member having a generally tubular expandable body with a proximal end and a distal end, the anchoring member being configured to be constricted to a contracted anchoring member and configured to be enlarged to an expanded anchoring member sized to contact the heart valve annulus;
providing a non-expandable/non-collapsible prosthetic valve member having a peripheral sewing ring on an inflow end and one-way leaflets configured to permit flow in an outflow direction through the valve member;
preparing the patient for surgery by placing him/her on cardiopulmonary bypass;
creating a direct access pathway to the heart valve annulus that permits direct naked eye vision of the heart valve annulus;
delivering the anchoring member to a position within the heart valve annulus and with the proximal end directed toward an outflow side of the annulus;
enlarging the anchoring member to the expanded anchoring member and into contact with the heart valve annulus;
delivering the valve member to the expanded anchoring member such that the one-way leaflets permit flow toward the outflow side of the annulus; and
coupling the sewing ring to the expanded anchoring member.

US Pat. No. 10,456,250

PRE-ASSEMBLED PACKAGED BIOPROSTHETIC VALVE CONDUIT

Edwards Lifesciences Corp...

1. A pre-assembled, packaged valved conduit, comprising:a bioprosthetic valve including bioprosthetic tissue, the valve having been treated such that the bioprosthetic tissue has less than 70% water content and may be stored dry for extended periods without degradation of functionality of the valve;
a conduit sealed with a bioresorbable medium to which the bioprosthetic valve is coupled so as to provide the valved conduit; and
dry packaging for the valved conduit including at least one sterile container in which the valved conduit is stored without a preserving solution.

US Pat. No. 10,456,249

PROSTHETIC HEART VALVE WITH PARAVALVULAR LEAK MITIGATION FEATURES

St. Jude Medical, Cardiol...

1. A prosthetic heart valve for replacing a native valve, comprising:a stent extending in an axial direction between an inflow end and an outflow end and having circumferential rows of cells formed by cell struts, the stent having a collapsed condition and an expanded condition;
a valve assembly disposed within the stent;
a first cuff disposed on a lumenal surface of the stent; and
a second cuff having a proximal edge facing toward the inflow end of the stent and a distal edge facing toward the outflow end of the stent, the second cuff being annularly disposed about one of the circumferential rows of cells and positioned radially outward of the first cuff and the stent;
wherein an ablumenal surface of selected cell struts forming the one circumferential row of cells has a concave curvature in a length direction of the selected cell struts when the stent is in the expanded condition, and
wherein each of the selected cell struts has end portions and a center portion between the end portions, and when the stent is in the expanded condition, a radial distance between the ablumenal surface of the center portion and the second cuff is greater than a radial distance between the ablumenal surface of each end portion and the second cuff,
wherein a lumenal surface of the selected cell struts is straight in the length direction of the selected cell struts when the stent is in the expanded condition.

US Pat. No. 10,456,248

TRUNCATED CONE HEART VALVE STENT

1. A method comprising:delivering to a native annulus of an atrioventricular valve of a heart a prosthetic valve via an opening in a wall of the ventricle of the heart, the prosthetic heart valve having a self-expanding body having a proximal end and a distal end, a valve disposed in the body, and
a plurality of self-expanding atrial anchoring elements distributed circumferentially about, and extending radially outwardly from, the proximal end of the body, and
a plurality of anchoring sutures, each anchoring suture having a first end and a second end, the first end being attached to the distal end of the body, the delivering including disposing the atrial anchoring elements on an atrium side of the native annulus and the anchoring sutures through the opening;
allowing the body to self-expand into engagement with the native annulus; and
fixing the plurality of anchoring sutures to the wall of the heart.

US Pat. No. 10,456,247

TRANSCATHETER VALVE PROSTHESIS

HIGHLIFE SAS, Paris (FR)...

1. A heart valve system, the system comprising:a radially self-expandable tubular body having a proximal-most end at an inflow end and a distal-most end at an outflow end; the tubular body including a plurality of arched beams at the outflow end of the tubular body,
a valve coupled to the tubular body, the valve including a plurality of valve leaflets; and
a fabric that is disposed over an outer surface of the tubular body and does not wrap around the outflow end of the tubular body, the fabric being directly connected to both the arched beams and an outer circumferential edge of the valve,
wherein:
connection points link the inflow end of the tubular body and the arched beams, a number of connection points being equivalent to a number of the valve leaflets,
each arched beam is directly attached to an adjacent arched beam such that the arched beams are continuous along the entire circumference of the tubular body at the outflow end, and
the arched beams and the connection points form the distal-most end of the tubular body.

US Pat. No. 10,456,246

INTEGRATED HYBRID HEART VALVES

Edwards Lifesciences Corp...

1. A hybrid prosthetic heart valve having an inflow end and an outflow end, comprising:a valve member including an undulating wireform with alternating cusps and commissures supporting a plurality of flexible leaflets configured to regulate one-way blood flow therethrough; and
an expandable inflow stent frame having a radially-expandable inflow end and an outflow end that undulates with peaks and valleys corresponding to an inflow end of the wireform, wherein the stent frame outflow end defines an implant circumference having a first diameter that enables physiological functioning of the valve member when implanted, and the stent frame outflow end includes integrated commissure posts located adjacent to and radially outward from the wireform commissures, the integrated commissure posts being separate elements from each other and from the stent frame and secured with sutures directly on top of and in alignment with the stent frame outflow end, each commissure post having a contoured lower ledge that matches a contour of one of the peaks in the undulating outflow end of the stent frame, the stent frame projecting in an inflow direction from an inflow end of the wireform, and further wherein the leaflets pass through the wireform commissures and attach to the commissure posts of the stent frame, wherein the stent frame outflow end permits post-implant expansion from the first diameter to an expanded diameter larger than the first diameter that disables physiological functioning of the valve member upon application of an outward dilatory force from within the outflow end substantially larger than forces associated with normal physiological use, and an identifier on the stent frame visible from outside the body after implant that identifies the stent frame as having an expandable outflow end.

US Pat. No. 10,456,245

SYSTEM AND METHOD FOR APPLYING MATERIAL TO A STENT

Edwards Lifesciences Corp...

1. A method of applying an electrospun material to an inner surface of a stent, the method comprising:coupling a mandrel to a stent body;
wherein the stent body comprises an inner surface defining a cavity and an outer surface opposing the inner surface, and
wherein the stent body has a length along an axis defined by the mandrel between a first end of the stent body and a second end of the stent body;
applying an electrospun material to at least a portion of the stent outer surface and to at least a portion of the mandrel to form a coating sheet;
wherein a portion of the coating sheet extends from at least one of the first end or second end of the stent to the mandrel; and
moving one or both of the stent and the mandrel to apply at least some of the portion of the coating sheet onto the inner surface of the stent body.

US Pat. No. 10,456,244

DEVICE AND METHOD FOR TEMPORARY OR PERMANENT SUSPENSION OF AN IMPLANTABLE SCAFFOLDING CONTAINING AN ORIFICE FOR PLACEMENT OF A PROSTHETIC OR BIO-PROSTHETIC VALVE

1. A surgical method for use in heart repair in a subject, comprising:providing an implantable scaffold including:
an inner margin element defining an orifice for receiving or seating a prosthetic or bio-prosthetic valve, and
a flexible outer margin element surrounding said inner margin element, said outer margin element and said inner margin element being different from one another and spaced in their entireties from one another, said outer margin element and said inner margin element being coplanar with one another in an expanded non-deformed pre-attachment configuration of said scaffold;
disposing said scaffold in said expanded non-deformed pre-attachment configuration inside a vascular system of a patient;
maneuvering said scaffold into position near a natural or native valve of the vascular system of the patient, the maneuvering of said expanded scaffold including manipulating a plurality of tethers or wires extending to said outer margin element, said manipulator tethers or wires being detachably connected at their distal ends directly to said outer margin element;
individually or independently manipulating said manipulator tethers or wires to deform said outer margin element so as to conform said outer margin element to an irregular internal wall surface of said vascular system;
attaching said outer margin element to said internal wall surface, the attaching of said outer margin element including applying at least one fastener or fixation mechanism to said outer margin element and said internal wall surface so that said outer margin element conforms to said internal wall surface; and
upon the attaching of said outer margin element, detaching said manipulator tethers or wires from said outer margin element and concomitantly from said scaffold.

US Pat. No. 10,456,243

HEART VALVES PROSTHESES AND METHODS FOR PERCUTANEOUS HEART VALVE REPLACEMENT

MEDTRONIC VASCULAR, INC.,...

1. A heart valve prosthesis having a compressed configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve in a patient, comprising:a frame including
a valve support having a first end and a second end, the valve support being configured to hold a prosthetic valve component therein, and
a plurality of support arms extending from the second end of the valve support, wherein when the heart valve prosthesis is in the expanded configuration,
the plurality of support arms are configured to extend toward the first end of the valve support for engaging a subannular surface of the native heart valve and
one or more of the plurality of support arms comprises a curvilinear-shaped support arm, the curvilinear-shaped support arm having
a first arcuate region being formed to curve toward the valve support proximate the second end,
a second arcuate region being formed to curve away from the valve support proximate the first end, and
a straight region being formed to slant toward the valve support in an upward and inward direction relative to a longitudinal axis of the valve support as the straight region extends from a first transitional point with the first arcuate region to a second transitional point with the second arcuate region,
wherein the second arcuate region defines a first curved segment that generally curves in an outward and upstream direction from the second transitional point to reach an apex of the curvilinear-shaped support arm and defines a second curved segment that extends in an outward direction from the apex of the curvilinear-shaped support arm and curves slightly downward toward a free-end of the curvilinear-shaped support arm,
wherein a landing zone configured to atraumatically engage tissue at the native heart valve is defined at the apex of the curvilinear-shaped support arm, the landing zone having a width that is greater than a width of the remainder of the curvilinear-shaped support arm.

US Pat. No. 10,456,242

INTRAOCULAR LENS THAT IMPROVES OVERALL VISION WHERE THERE IS A LOCAL LOSS OF RETINAL FUNCTION

AMO Groningen B.V., Gron...

1. An intraocular lens configured to improve vision for a patient's eye, the intraocular lens comprising:an optic comprising a first surface and a second surface opposite the first surface, the first surface and the second surface intersected by an optical axis, the optic being symmetric about the optical axis, wherein the first and the second surface of the optic are aspheric, the first surface having a first radius of curvature and a first conic constant and the second surface having a second radius of curvature and a second conic constant,
wherein the first surface of the optic is configured to face the cornea and the second surface of the optic is configured to face the retina when the optic is implanted in the patient's eye,
wherein the first radius of curvature is less than the second radius of curvature,
wherein the first conic constant is greater than the second conic constant, and
wherein the optic is configured to improve image quality of an image produced by light incident on the patient's eye at an oblique angle with respect to the optical axis and focused at a peripheral location disposed at a distance from the fovea and at an eccentricity between about 1 degree and about 25 degrees with respect to the optical axis at the fovea.

US Pat. No. 10,456,241

SWITCHABLE LENS DEVICES, SYSTEMS, AND RELATED METHODS

ELWHA LLC, Bellevue, WA ...

1. A lens system, comprising:at least one switchable lens device sized and configured to be placed in association with at least one of a first eye of a subject or a second eye of the subject, the at least one switchable lens device including at least one switchable lens having a plurality of optical settings and being configured to selectively switch at least between a first optical setting of the plurality of optical settings and a second optical setting of the plurality of optical settings;
wherein the first optical setting includes at least one of a first focal spot or a first visible-light-transmittance setting of the at least one switchable lens;
wherein the second optical setting includes at least one of a second focal spot or a second visible-light-transmittance setting of the at least one switchable lens; and
a controller operably coupled to the at least one switchable lens device, the controller including control electrical circuitry configured to:
receive one or more audible inputs from the subject;
correlate the one or more received audible inputs with the first optical setting of the plurality of optical settings; and
direct switching of the at least one switchable lens from the first optical setting of the plurality of optical settings to the second optical setting of the plurality of optical settings,
wherein at least one of:
the controller is configured to filter out at least one of voice commands from persons other than the subject or non-command signals from the subject;
the one or more audible inputs include at least one of clapping, clicking, clacking of teeth, one or more words, one or more phrases, one or more numbers, or one or more parameters; or
the one or more audible inputs include one or more of a series, sequence, or pattern of non-verbal commands or sounds.

US Pat. No. 10,456,239

ANASTOMOTIC CONNECTOR AND SYSTEM FOR DELIVERY

PHRAXIS INC., St. Paul, ...

1. A vessel anchor for use in an arteriovenous anastomotic connector device comprising:an arteriovenous anastomotic connector device having an elastic tubular main body defining a lumen therewithin and formed from a plurality of struts and connectors, said elastic tubular main body including a distal end and a proximal end;
a plurality of flanges each having first and second flange ends integrally formed with said tubular main body and a third flange tip end, said plurality of flanges movable between a loaded position and an expanded position, wherein in the expanded position the flanges seat said vessel anchor against an inner wall of an artery, and
a plurality of finger-like tines, each having a first tine end integrally formed with said tubular main body adjacent said proximal end and an unattached, second tine end that extends inwardly into the lumen of said main body at an acute angle, wherein said arteriovenous anastomotic connector device connects a fluid blood flow in an artery to a fluid blood flow in a vein.

US Pat. No. 10,456,238

ARTIFICIAL STOMACH

1. A method for surgically placing an artificial stomach in a patient, the method comprising the steps of:cutting an opening in the abdominal wall of the patient,
dissecting an abdominal area,
placing the artificial stomach in the dissected abdominal area, comprising:
a food reservoir adapted to collect food,
an inlet connected to a first opening of the food reservoir and further being adapted to directly or indirectly upstream connect to the patient's gastrointestinal tract, and
an outlet connected to a second opening of the food reservoir and further being adapted to downstream connect to the patient's gastrointestinal tract,
an inlet valve placed between the patient's gastrointestinal tract and the first opening of the food reservoir,
connecting the inlet comprising the inlet valve of the food reservoir upstream to the patient's gastrointestinal tract,
connecting the outlet of the food reservoir downstream to the patient's gastrointestinal tract, and
implanting a source of energy in the patient, adapted to be charged non-invasively with wireless energy, and adapted to be controlled to release energy for use in connection with the operation of the artificial stomach.

US Pat. No. 10,456,237

ESOPHAGEAL STENT INCLUDING A VALVE MEMBER

BOSTON SCIENTIFIC SCIMED,...

1. An expandable medical device, comprising:a tubular scaffold, the scaffold including a first end, a second end opposite the first end, an inner surface defining a lumen extending from the first end to the second end, an outer surface opposite the inner surface, and a central longitudinal axis extending from the first end to the second end, the scaffold formed of a plurality of struts defining openings therebetween, the openings extending from the inner surface to the outer surface through a wall of the scaffold;
a flexible valve extending radially inward from the inner surface of the scaffold into the lumen of the scaffold between a first circumferential location and a second circumferential location;
an inner layer of polymer material disposed on the scaffold and extending across the openings from the first circumferential location to the first end of the scaffold and from the second circumferential location to the second end of the scaffold, the flexible valve being formed from a portion of the inner layer extending between the first circumferential location and the second circumferential location which is spaced away from the scaffold between the first circumferential location and the second circumferential location; and
an outer layer of polymer material disposed on the scaffold and extending across the openings between the first circumferential location and the second circumferential location;
wherein the inner layer is circumferentially attached to the outer layer at the first circumferential location and the inner layer is circumferentially attached to the outer layer at the second circumferential location to form an annular chamber extending circumferentially around the central longitudinal axis of the scaffold between the first circumferential location and the second circumferential location, the annular chamber bounded by an inner surface of the inner layer extending from the first circumferential location to the second circumferential location and a surface of the outer layer extending from the first circumferential location to the second circumferential location;
wherein the valve narrows from the first circumferential location to a closure point of the valve, the valve being configured to shift from a closed configuration to an open configuration;
wherein the valve is configured to permit material to pass through the closure point of the valve from the first end to the second end, wherein the valve includes a surface texture configured to prohibit material from moving through the closure point of the valve from the second end to the first end, wherein the surface texture is only on a downward facing surface of the valve located between the closure point and the second circumferential location, wherein the surface texture is on an outer surface of the inner layer opposite the inner surface of the inner layer, the inner surface of the inner layer being devoid of the surface texture.

US Pat. No. 10,456,236

AXIAL LENGTHENING THROMBUS CAPTURE SYSTEM

KP Medcure, Inc., Anahei...

10. A method of using a clot capture system to redistribute a thrombus, comprising:providing a tubular body comprising a first end and a second end, the first end having an opening, wherein the tubular body comprises a first configuration in which the first end is expanded and the tubular body has a first expanded axial length, wherein the second end is compressed in the first configuration, wherein the tubular body has a folded portion between the first end and the second end such that a compressed portion of the tubular body is within an expanded portion of the tubular body, wherein the tubular body surrounds a thrombus in the first configuration,
redistributing a thrombus by transforming the tubular body to a second configuration in which the tubular body has a second expanded axial length greater than the first expanded axial length, wherein the folded portion is moved away from the thrombus to create additional space within the expanded portion of the tubular body, and
transforming the tubular body to a third configuration in which the tubular body has a third expanded axial length less than the second expanded axial length.

US Pat. No. 10,456,234

CONICAL VENA CAVA FILTER WITH JUGULAR OR FEMORAL RETRIEVAL

COOK MEDICAL TECHNOLOGIES...

1. A method for retrieving an intravascular filter from a patient's vena cava through the patient's femoral vein, the method comprising:percutaneously inserting a retrieval assembly into the patient's vasculature through the patient's femoral vein, the retrieval assembly comprising a retrieval sheath and a control member;
advancing the retrieval assembly through the patient's vasculature to a retrieval position proximal to the intravascular filter in the patient's vena cava, the intravascular filter being in a filtering configuration and comprising:
a plurality of struts having first and second ends, the first ends of the struts being attached together along a longitudinal axis, the second ends of the struts being attached together along the longitudinal axis, each strut having a first portion, a second portion, and a third portion, the third portion of each strut being substantially linear and having a bending region substantially straight in the filtering configuration, the first portion extending laterally away from the longitudinal axis and generally upstream from the first end, the second portion extending generally upstream from the first portion, the third portion extending inwardly toward the longitudinal axis and generally downstream from the second portion to the second end, the first portion and the third portion being substantially parallel in the filtering configuration;
a first coupling element disposed with the first ends of the struts for jugular vein retrieval; and
a second coupling element disposed with the second ends of the struts for femoral vein retrieval;
attaching the control member to the second coupling element of the intravascular filter;
retracting the control member proximally through the retrieval sheath to apply tension to the second coupling element, the tension moving the intravascular filter from the filtering configuration to a retrieval configuration, each strut extending generally upstream from the first end to the second end when the filter is in the retrieval configuration;
advancing the retrieval sheath distally over the intravascular filter; and
removing the retrieval assembly and the intravascular filter from the patient's vasculature.

US Pat. No. 10,456,232

TILTABLE IMPLANTABLE MEDICAL DEVICE

Cook Medical Technologies...

1. An implantable medical device for deployment in a vessel of a patient, the implantable medical device including a first capture element formed of a first frame of curved leg elements with a first end opening, the first frame providing a material capture chamber therein accessible through the first end opening; a coupling member attached to the frame; and a stabilization member attached to the coupling member for stabilizing the capture element, wherein the stabilization member is a second capture element formed of a second frame of curved leg elements with a second end opening, each of the first frame and the second frame providing a material capture chamber therein accessible through each of the end openings, and wherein the first and second capture elements have their end openings facing a common direction, wherein at least one of the first capture element and the second capture element is configured to tilt at a tilt angle to extend non-parallel to a longitudinal axis of the vessel while maintaining proper contact to a wall of the vessel.

US Pat. No. 10,456,231

REINFORCEMENT DEVICE WITH DISSOLVABLE LAYER AND ITS USE

Covidien LP, Mansfield, ...

1. A reinforcement device for reinforcing tissues having one or more structural deficiencies, comprising:a longitudinally extending reinforcing layer for treating the structural deficiency, the layer having a first face and a second face;
a plurality of naps distributed across at least the first face and projecting therefrom for adhering to tissue, the plurality of naps having one of an arcuate shape with a flattened ball at the distal end of the plurality of naps, a tapered point, or J-hook shape; and
a dissolvable layer.