US Pat. No. 10,244,857

ORAL CARE IMPLEMENT AND FILAMENT FOR THE SAME

Colgate-Palmolive Company...

1. A mechanically tapered filament for an oral care implement, the filament comprising:an elongated shaft terminating in a tip and having a mounting end portion of constant cross section and a tapered end portion;
wherein the tapered end portion has a taper length of 5 mm or more;
wherein the tapered end portion has an areal surface roughness value of at least 0.20; and
wherein the filament has a Nelson Ratio between 0.8 to 1.20.

US Pat. No. 10,244,856

UNIVERSAL PHALANGI GRIP SYSTEM FOR TOOTHBRUSH AND UTENSILS

1. A toothbrush for individuals with impaired hand gripping ability comprises,a handle portion and a brush portion,
said handle portion of unitary construction having an elongated rigid support base,
an integral upstanding flexible segmented finger engagement portion with multiple longitudinally spaced finger engagement openings therein, each of the finger engagement openings having an associated upper opening with a dimension along the length of the handle that is less than the respective figure engagement opening,
intermediate connective web portions between said respective finger engagement openings, upper ends of adjacent web portions defining each respective upper opening,
said brush portion having an elongated support extending longitudinally from said support base, a brush head having a co-mingled bristle pattern extending therefrom.

US Pat. No. 10,244,855

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle extending along a longitudinal axis from a proximal end to a distal end; and
a head having a front surface and an opposite rear surface, the head comprising:
a cantilever connected to and extending longitudinally from the distal end of the handle, the cantilever having a front surface, a rear surface, and a distal end;
a rigid plate having a front surface, a rear surface, a first portion, a second portion, and a distal end, the rear surface of the rigid plate spaced from the front surface of the cantilever by a gap, and the distal end of the rigid plate spaced away from the distal end of the handle along the longitudinal axis; and
a resilient material in the gap flexibly coupling the rigid plate to the cantilever, the resilient material covering, via direct surface contact, an entirety of the rear surface of the rigid plate and an entirety of the front surface of the cantilever;
wherein the first portion of the rigid plate extends longitudinally beyond the distal end of the cantilever and the second portion of the rigid plate overlaps the cantilever, the resilient material extending from the distal end of the cantilever to the distal end of the rigid plate.

US Pat. No. 10,244,854

GRIPPING APPARATUS FOR HANDHELD DEVICES

Tzumi Electronics LLC, N...

1. An apparatus for assisting a user in gripping a portable electronic device, the apparatus comprising:a base element adapted to be attached to the portable electronic device, wherein the base element has a top surface with an attachment region and a bottom surface configured to mount the base element onto the portable electronic device;
a gripping element, wherein the gripping element has a bottom surface with an attachment region; and
a stretchable cord connecting the base element and the gripping element at the respective attachment regions thereof,
wherein the stretchable cord is sufficiently elastic to allow the gripping element to be extended away from the base element a sufficient distance for a user to insert one or more fingers between the gripping element and the base element, to grip the user's fingers when they are inserted between the gripping element and the base element, and to snap back against the base element when the user's fingers are removed;
whereby the stretchable cord is sufficiently elastic to allow the gripping element to automatically adjust a tightness of its grip to a thickness of the user's fingers when they are inserted between the gripping element and the base element;
wherein the attachment regions of the base element and of the gripping element have respective corresponding engaging elements that cooperate with one another to permit the base element and the gripping element to be secured against or engaged with one another when the user's fingers are removed from between the gripping element and the base element.

US Pat. No. 10,244,853

APPARATUS AND METHOD FOR ASSISTING CARRYING OF OBJECTS BY HAND

1. An apparatus for assisting a person in hand carrying objects having handles, by distributing most of the weight of the object to the person's wrist comprising:a loop of flexible material having a loop perimeter length, and
a loop stiffener located along a first portion of said loop, said loop stiffener spanning less than one third of said loop perimeter length and configured for control of the object by the person's fingers,
said loop of flexible material comprising padding only at a second portion of said loop, said padding being adapted for padding the wrist and wherein portions of said loop of flexible material not covered by said padding are adapted for supporting the object at two contact points and wherein said second portion is wider than the remainder of the loop of flexible material and is contoured to fit the wrist.

US Pat. No. 10,244,852

BEACH EQUIPMENT CARRIER AND LOCATING POLE

1. Apparatus comprising:a two-person carrier assembly configured for carrying beach, picnic or tailgating equipment and being changeable to a position-marking pole, the assembly further comprising:
an outer base tube,
an intermediate tube slidable within the outer base tube,
an inner top tube slidable within the intermediate tube,
first and second fixing connections connect the outer base tube, the intermediate tube and the inner tube,
wherein the fixing connections are releasable and fixable in different positions and are adapted for fixing the outer base tube, the intermediate tube and the inner tube in a carrier configuration, with the intermediate tube extended from the outer base tube and the inner tube fixed within the intermediate tube, and
wherein the fixing connections are adapted for fixing the outer base tube, the intermediate tube and the inner tube extended in a position-marking pole configuration, wherein the fixing connections further comprise pin-receiving holes in the tubes adapted for aligning with pin-receiving holes in other of the tubes, and lock pins adapted for insertion in the pin-receiving holes, wherein the lock pins are removable from the holes and repositionable.

US Pat. No. 10,244,851

BAG CARRIER

1. A bag carrier comprised of a carrier and a strap;the strap at a first end and a second end is affixed to a ring;
the strap is bisected by a buckle that adjusts a length of the strap;
the length of the strap sufficient so that when the strap is placed over a shoulder of a user the ring lies adjacent to the user's hip;
the carrier has a frame;
the frame has on a lower side a bag hook;
the frame has on an upper side a handle;
the frame has on a first side a support hook;
the support hook connects to the ring;
a handle on a shopping bag attaches to the bag hook.

US Pat. No. 10,244,850

AUTOMATIC OPENING FOR A COMPARTMENT IN A PACK

The North Face Apparel Co...

1. A wearable pack having at least one shoulder strap, comprising:a front surface and an opposing back surface, opposing side surfaces, and opposing top and bottom surfaces, the surfaces being arranged to define a compartment of a backpack;
the front surface having upper and lower portions, the upper portion comprising a hingeable section hingeably coupled to the lower portion, the hingeable section having a first condition providing an opening to the compartment in the pack and a second condition closing the opening to the compartment, wherein the front portion is movable relative to the back portion by the front portion's hinging along a joint that is defined by (1) a lower end of the hingeable section and (2) the top end of the lower portion of the front surface;
a closure system for locking the hingeable section in the closed condition; and the hingeable section being coupled to a spring system that is unloaded when the
hingeable section is in the first condition and relatively loaded when in the second condition so that the compartment automatically opens when the closure system is released.

US Pat. No. 10,244,849

BOTTLE HOLDING SYSTEM FOR BACKPACKS

1. A bottle holding system for use by a wearer of a hiking backpack having one or more shoulder straps forwardly situated and secured to the backpack in support of a rear casing thereon having an exterior side and an interior compartment, comprising:an inflatable cuff member formed having a cylindrical and open-ended configuration with an open top and an open bottom in both a deflated and inflated condition, said cuff member being positioned for mounted attachment to the exterior side of the rear casing and sized to fit around a bottle of drinking fluid along the length thereof so that the bottle is retained exclusively within the cylindrical configuration of said cuff member when inflated and released therefrom through the open bottom to a hand of the wearer when deflated;
banded means for attaching said cuff member to the exterior side of the rear casing, said banded means comprising a flexible band member assembled about said cuff member and connected to the rear casing;
a length of tubing connected at one end thereof to said cuff member and routed from the positioned attachment of said cuff member along the interior compartment of the rear casing, said length of tubing further extending outwardly from the rear casing in proximity to the shoulder straps;
a bulb member flexible in form and coupled to receive the other end of said length of tubing, said bulb member being mounted on a selected one of the shoulder straps; and
an air release valve connected in-line between said bulb member and the other end of said length of tubing, said air release valve having a controlled actuation to cause a pressure release from said valve and a deflation of said cuff member.

US Pat. No. 10,244,848

GROOMING MIRROR

1. A grooming mirror for assisting a user with clipping facial hair, so that hair clippings are captured for disposal without littering a bathroom area, the grooming mirror comprising:a reflective mirror mounted on a housing;
a base attached to and extending from the housing for operatively supporting the reflective mirror for use by the user;
a clippings catching sheet for catching the hair clippings; and
a rigid framework that extends from the base to support the clippings catching sheet beneath the reflective mirror, wherein the rigid framework includes a plurality of rigid spokes that extend outwardly from the base to support the clippings catching sheet beneath the reflective mirror for catching the hair clippings.

US Pat. No. 10,244,847

COSMETIC APPLICATOR WITH ALIGNING CAP

HCT GROUP HOLDINGS LIMITE...

1. A combination cosmetic bottle and cap comprising:a cosmetic bottle defining a reservoir for containing a cosmetic product and having an open end with a collar configured for engagement with the cap, wherein the collar comprises a first ramped edge and a second ramped edge each extending around less than the full perimeter thereof, each having an upper end and a lower end, the lower ends thereof each adjacent to a slot;
a cap coupled to an applicator, with a connecting structure therebetween having at least a tab thereon for aligning the cap with the collar;
wherein the tab is configured for sliding engagement against the ramped edge of the collar and to fit within the slot to removably and replaceably secure the cap in a desired alignment with the collar, further comprising a click feature having a protrusion on the collar and an indentation on the connecting structure, and configured to click upon full insertion of the tab into the slot to secure the cap to the bottle, wherein upon full insertion of the tab into the slot to secure the cap to the bottle, the protrusion and the indentation form a snap fit;
wherein the first and second ramped edges extend about first and second arcs, respectively, the first and second arcs each spanning an arc in the range of about 90 to about 170 degrees relative to a central axis of the collar.

US Pat. No. 10,244,846

COSMETIC IMPREGNATED FOAM MANUFACTURING METHOD

CIT CO., LTD., Chungcheo...

1. A method of manufacturing a cosmetic impregnated foam, comprising:a) forming a pattern and filling a container with two or more liquid-state make-ups wherein the liquid-state make-ups have different colors and different viscosities;
b) putting an impregnated foam with a fabric thereon into the liquid-state make-ups in the container and performing impregnation; and
c) separating the impregnated foam and the fabric.

US Pat. No. 10,244,845

CONTAINER AND APPLICATOR FOR POWDERS AND LIQUIDS

Presto Packaging Solution...

1. A combined container cap and applicator, for the transfer of a powdered or liquid material from the container and for application of the material to a substrate, comprising an applicator sponge mounted to the interior of the cap via a rotating holder, and a wiper mounted to the container, wherein(a) the cap is a threaded cap, the threads being a first set of threads which are complimentary to threads on the container;
(b) the holder moves helically with respect to the cap; and
(c) the wiper reversibly holds the sponge by friction in a fixed position relative to the container when the container is closed by the cap; such that
(d) when the cap is unscrewed from the container, the wiper holds the sponge and the holder fixed relative to the container, causing the holder and sponge to move helically outward relative to the cap, and
(e) when the cap is screwed onto the container, the wiper holds the sponge and the holder fixed relative to the container, causing the holder and sponge to move helically inward relative to the cap;whereby the helically outward and helically inward motions, respectively, result in a telescopic motion of the holder outward and inward with respect to the cap.

US Pat. No. 10,244,844

COSMETIC CONTAINER HAVING APPLICATION MEMBER DETACHABLY ATTACHED TO SIDE OF BUTTON MEMBER

PUM-TECH KOREA CO., LTD.,...

1. A cosmetic container having an application member detachably attached to a side of a button member, the cosmetic container comprising:a container body (10) having a storage space (13);
a pump (20) for discharging contents of the container body (10);
a cap (30) for fixing the pump (20) to the container body (10);
the button member (40) coupled to an upper part of the pump (20) and formed to protrude upward of the cap (30); and
the application member (50) detachably attached to the side of the button member (40),
wherein the button member (40) comprises:
a first outlet (41) through which discharging contents from the pump (20) passes; and
a push protrusion (42) on an upper surface of the button member (40), and
wherein the application member (50) comprises a second outlet (55) through which discharging contents from the first outlet (41) passes.

US Pat. No. 10,244,843

COSMETIC CONTAINER HAVING A FIBROUS APPLICATOR

ZHUHAI DING RONG PLASTIC ...

1. A cosmetic container comprising:an enclosure including an opening;
a cup shaped mount including an externally and internally extending rim disposed on the opening of the enclosure for partially disposing the cup shaped mount in the opening of the enclosure, a bottom portion, at least one port adjacent to the bottom portion, at least one valve each disposed in the at least one port, and a main portion spaced from the bottom portion;
a hollow plunger partially disposed in the cup shaped mount and including an annular flange on an outer surface and disposed externally of the enclosure, an inner case partially disposed in the main portion, a first channel defined by the inner case, an outer case extending outward from the annular flange, and a second channel defined by the outer case;
a biasing member disposed in the main portion and put on the inner case so that the plunger is configured to slide relative to the mount;
a flexible fibrous applicator including an application head and a rear, cylindrical fastening member disposed in the second channel, a tunnel extending through the rear, cylindrical fastening member into the application head, and an annular shoulder between the application head and the rear, cylindrical fastening member, with the shoulder having an outer diameter greater than an outer diameter of the fastening member; and
a cap releasably secured to the opening of the enclosure;
wherein the inner case is configured to open or close the at least one valve.

US Pat. No. 10,244,842

BLADE DISPOSAL CONTAINER

1. A blade disposal container, comprising: a housing including an upper end, a base, a first sidewall opposing a second sidewall, a rear wall, and an open front face, the open front face including a perimeter edge;a slot extending through the upper end into the interior volume, the slot configured to receive a blade therethrough;
a shield slidably disposed over the open front face; a channel disposed adjacent the perimeter edge, the channel configured to slidably receive the shield; and
a magnetic member removably coupled to the base, the magnetic member configured to draw a blade into the interior volume and magnetically adhere the blade to the base, and wherein the magnetic member includes a width larger than a width of the base, the magnetic member configured to cover the opening of the perimeter edge and fasten the shield over the open front face.

US Pat. No. 10,244,841

STRUCTURE OF HAND-CARRYING PORTION OF BAG AND METHOD FOR ATTACHING THE SAME

HAYASHIGO CO., LTD., Osa...

1. A structure of a hand-carrying portion attached to a bag main body, comprising:an outer side hand-carrying member; and
an inner side hand-carrying member partially overlapped with an inner side of the outer side hand-carrying member,
wherein the inner side hand-carrying member is a long, band-shaped body, and the outer side hand-carrying member is a long, band-shaped body having a wider width than the inner side hand-carrying member,
the outer side hand-carrying member and the inner side hand-carrying member have different lengths, the outer side hand-carrying member being longer than the inner side hand-carrying member,
the inner side hand-carrying member is joined with the outer side hand-carrying member on an outer surface covered by the outer side hand-carrying member in a joining region including a hand-carrying region,
the inner side hand-carrying member has a non-joining region, which is not sewn to the outer side hand-carrying member, the non-joining region being a flat, band-shaped portion of the long, band-shaped body that makes up the inner side hand-carrying member,
the outer side hand-carrying member is joined to an outer side of the inner side hand-carrying member in the joining region including the hand-carrying region, and the outer side hand-carrying member is curved to a U-shape with the inner side hand-carrying member in the hand-carrying region in a front view,
the outer side hand-carrying member is folded around the inner side hand-carrying member to form an overlapped region centered between one end of the inner side hand-carrying member and another end of the inner side hand-carrying member, and centered between one end of the outer side hand-carrying member and another end of the outer side hand-carrying member,
the outer side hand-carrying member and the inner side hand-carrying member are sewn together in a vicinity of a longitudinal end edge of the outer side hand-carrying member and a vicinity of a longitudinal end edge of the inner side hand-carrying member to form a sewing portion in the overlapped region so as to form the joining region including the hand-carrying region,
the one end of the inner side hand-carrying member is attached to the outer surface of the main bag body at one attachment portion, and the another end of the inner side hand-carrying member is attached to the outer surface of the main bag body at another attachment portion,
the sewing portion extends to a vicinity of the one end of the inner side hand-carrying member and a vicinity of the another end of the inner side hand-carrying member, such that a space exists between the sewing portion and the one attachment portion, and a space exists between the sewing portion and the another attachment portion,
the outer side hand-carrying member includes a flat-shaped extended region that extends in a top-to-bottom direction of the bag main body from the joining region including the hand-carrying region overlapped with the inner side hand-carrying member,
in the extended region of the outer side hand-carrying member, the outer side hand-carrying member has a non-joining region where the outer side hand-carrying member is not sewn to the inner side hand-carrying member,
the non-joining region includes a sandwiching portion for sandwiching an article in a space between the inner side of the outer side hand-carrying member and the outer surface of the bag main body,
the outer side hand-carrying member is attached, at one end, to the outer side of the bag main body at a first lower attachment portion in the extended region of the outer side hand-carrying member, and, at another end, to the outer side of the bag main body at a second lower attachment portion, the first and second lower attachment portions spaced apart from each other, such that an interval exists between the one attachment portion of the inner side hand-carrying member and the first lower attachment portion of the outer side hand-carrying member and between the another attachment portion of the inner side hand-carrying member and the second lower attachment portion, and
the lower attachment portion includes a flat portion of the outer side hand-carrying member brought into contact with, and sewn to, the outer surface of the bag main body.

US Pat. No. 10,244,840

JEWELRY STORAGE DEVICE AND DISPLAY METHOD THEREOF

SHENZHEN DIKAI INDUSTRIAL...

1. A jewelry storage device, comprising:a box body unit which comprises a first body, a second body, and a connecting axle, wherein said first body comprises a plurality of first connecting members spacedly and inwardly formed at a rear side of said first body, wherein said second body comprises a plurality of second connecting members spacedly and inwardly formed at a rear side of said second body, wherein said first and second connecting members are coupled with each other by said connecting axle to pivotally connect said first body with said second body between a storage position that said second body is covered by said first body, and a display position that said first body is pivotally moved away from said second body, wherein said first and second connecting members are not protruded from said rear sides of said first and second bodies respectively; and
a locking unit which comprises a mortice lock member provided at a front side of said first body and a locking member provided at a front side of said second body in a hidden manner, wherein said mortice lock member is releasably coupled to said locking member to lock up said second body with said first body at said storage position, wherein said mortice lock member and said locking member are not protruded from said front sides of said first and second bodies respectively, such that said box body unit has no protruded portion formed at said first and second bodies.

US Pat. No. 10,244,839

CASE WITH INCREASED DEVICE RETENTION FROM A MICRO-TEXTURED LIP

Apple Inc., Cupertino, C...

17. A method for forming a case for an electronic device, the method comprising:shaping a substrate to form a bottom wall and side walls that extend from the bottom wall at a first angle relative to the bottom wall, wherein the side walls terminate at a first edge that extends from the side walls at a first angle, and the first edge defines an opening that leads to a cavity having a size and shape suitable for accommodating the electronic device; and
forming a securing element that extends from at least one of the side walls and towards the cavity at a second angle, wherein the securing element terminates at a second edge different than the first edge, and the securing element is overlaid by the first edge, and wherein the second edge of the securing element is capable of contacting an external surface of the electronic device so as to (i) allow insertion of the electronic device through the opening and into the cavity, and (ii) prevent movement of the electronic device out of the cavity.

US Pat. No. 10,244,838

PROTECTIVE CASE FOR PORTABLE ELECTRONIC DEVICE WITH FOLDABLE LENS COVER AND STORAGE COMPARTMENTS

1. A protective case for a portable electronic device, the portable electronic device including a back having a camera lens, the protective case comprising:a) a back portion secured to the back of the portable electronic device, the back portion having a camera lens cover configured to protect the camera lens when in a closed position;
b) at least one storage compartment integrated within the camera lens cover of the back portion of the protective case, the storage compartment having a plurality of walls that substantially enclose all sides of an open internal space sufficient to store an item without the item falling out of the storage compartment, the plurality of walls defining a uniform internal depth;
wherein the camera lens cover makes up a sub-part of the back portion of the protective case, with a non-lens-cover portion comprising the remaining part of the back portion,
wherein the camera lens cover abuts the non-lens-cover part along a straight edge of the camera lens cover, and
wherein a hinge connects the non-lens-cover part to the straight edge of the camera lens cover, and further wherein the camera lens cover rotates around the hinge when repositioned between an open position and the closed position.

US Pat. No. 10,244,837

EXPANDABLE AND TRANSPORTABLE BAG

Everything Sneakey, LLC, ...

1. A device comprising:a. a lanyard suitable for wearing around a user's neck and including two sleeve portions each having at least one opening and at least one cavity inside the lanyard;
b. a mesh that is attached to each of the at least one cavities inside the lanyard;
c. at least one opening of each sleeve portion is slidable away from the other opening and over the mesh to deploy the mesh from the cavity over the mesh; and
d. the mesh is removable from inside the lanyard to form a bag.

US Pat. No. 10,244,836

AUTOMATIC INVERSELY FOLDABLE UMBRELLA

1. An automatic inversely foldable umbrella, comprising:a skeleton structure, wherein the skeleton structure further comprises:
a main shaft;
an upper runner fixed to one end of the main shaft;
a lower runner slidably disposed on the main shaft;
a middle runner slidably disposed on the main shaft between the upper runner and the lower runner, the middle runner including a first connecting end facing the upper runner and a second connecting end facing the lower runner;
plural skeleton linkages, each skeleton linkage including a first rib, a second rib, and a foldable rib, one end of the first rib pivotally disposed on the second connecting end of the middle runner, one end of the foldable rib pivotally disposed on the upper runner with the other end of the foldable rib pivotally connected to an end of the first rib away from the middle runner, one end of the second rib pivotally disposed on the first connecting end of the middle runner with the other end of the second rib pivotally disposed on the foldable rib;
plural linking members, one end of each linking member pivotally disposed on the lower runner with the other end of the linking member connected with the corresponding first rib;
a resilient member disposed between the middle runner and the lower runner, the resilient member compressed due to a movement of the middle runner and the lower runner;
a first canopy combined to the upper runner;
a second canopy combined to the lower runner, the first canopy and the second canopy covering the skeleton linkages; and
a handle combined to the main shaft and disposed away from the upper runner, the handle including a control structure optionally engaging the lower runner,
each foldable rib provided with a first disposition portion and a second disposition portion, the first disposition portion disposed adjacent to a joint where the first canopy contacts the second canopy, the second disposition portion disposed between the first disposition portion and the upper runner, the first disposition portion pivotally connected to the corresponding first rib, the second disposition portion pivotally connected to the corresponding second rib;
a plurality of pulling members, each pulling member disposed between the foldable rib and the corresponding first rib of each skeleton linkage, respectively, with one end of the pulling member and the corresponding second rib disposed on the corresponding second disposition portion, and another end of the pulling member winding around the first rib.

US Pat. No. 10,244,835

UMBRELLAS WITH INFLATABLE PORTIONS

The Handwerker Umbrella C...

1. An umbrella comprising:a support assembly having a first end and a second end, the support assembly comprising an air pump; and
a canopy assembly comprising:
a hub fixed to the second end of the support assembly;
a plurality of support ribs attached to the hub;
a sheet coupled to the hub;
a toroidal air bladder coupled to the air pump, the air bladder disposed about a handle between the hub and the first end of the support assembly; and
a plurality of support straps, each support strap extending from an upper surface of the hub to a lower surface of the toroidal air bladder when the umbrella is positioned for use.

US Pat. No. 10,244,834

BEAD BRACELET LOOM

1. A loom for creating a beaded bracelet, the loom comprising:a track;
a clip disposed at one end of the track and configured to hold a portion of a cord; and
a holder disposed on the track and spaced apart from the clip, the holder including a key that engages a portion of the track to maintain a position of the holder spaced apart from the clip, the holder including spring portion holding a cord clip portion configured to hold another portion of the cord and maintain a desired tension on the cord between the clip and the holder, wherein the spring portion of the holder comprises a curved shape extending from a base portion, the clip portion disposed on end of the curved shape for extending the desired tension on the cord.

US Pat. No. 10,244,833

FOUR-STONE SEAMLESS RADIANT CUT DIAMOND AND METHOD FOR MAKING THE SAME

1. A method of cutting a diamond from a princess cut diamond, said princess cut diamond comprising:a table;
a crown disposed below the table
a girdle disposed beneath the crown, wherein the girdle comprises four facets forming a substantially rectangular shape, wherein the four facets comprise a first facet, a second facet substantially perpendicular to the first facet, a third facet substantially perpendicular to the second facet, and a fourth facet substantially perpendicular to the third facet and substantially perpendicular to the first facet;
a pavilion disposed below the girdle, and
a culet directly below a point substantially at the center of the girdle, wherein the method comprises:
making a cut parallel to the third facet, proceeding from the second facet to the fourth facet, thereby:
removing a portion of the crown and pavilion,
shortening the second facet and the fourth facet into a shortened second facet and a shortened fourth facet, respectively, and
resulting in a first new girdle facet, wherein the first new girdle facet is directly connected to the table;
making a cut parallel to the shortened fourth facet, proceeding from the first new girdle facet to the third facet, thereby:
removing another portion of the crown and the pavilion,
shortening the third facet into a shortened third facet,
shortening the first new girdle facet into a shortened first new girdle facet having a first measurement,
resulting in a second new girdle facet having a second measurement, wherein the second new girdle facet is directly connected to the table, and perpendicular to the shortened first new girdle facet, and
wherein the shortened first new girdle facet and the second new girdle facet meet at a first point;
cutting the pavilion such that the culet is directly under a second point that is within 1% deviation of half the first measurement from the first point and half the second measurement from the first point, and
cutting a radiant facet connecting two of the shortened first new girdle facet, the second new girdle facet, the shortened third girdle facet, and the shortened fourth girdle facet.

US Pat. No. 10,244,832

DOUBLE LOCK MECHANISM

Patdiam Jewellery Limited...

1. A double lock mechanism comprising:a post section comprising a locking post and a plurality of post slots recessed into the locking post; and
a locking section configured to engage the post section, the locking section comprising:
an insertion cavity configured to receive the locking post;
a plurality of locking bars, each locking bar comprising an outwardly facing side and an inwardly facing side,
wherein each of the outwardly facing sides comprises a grip surface, and
wherein each of the inwardly facing sides comprises a first end having a locking tip configured to engage one of the plurality of post slots, a second end having a spring tip, and an attachment point between the first end and second end at which each of the locking bars are pivotally coupled to the locking section, wherein the attachment point of each of the inwardly facing sides share a common pivoting axis comprising a pin to which the locking bars are attached to each other and about which the locking bars pivot,
wherein a distance from each of the locking tips to the attachment points on the respective locking bars are of different lengths such that the locking tips are offset along the locking post from each other, and
a spring having two ends, each end attached to each of the spring tips, the spring configured to spread the spring tips away from each other and bias the locking bars in an engaged orientation relative to the post slots, such that the locking tips engage the post slots;
wherein the plurality of locking bars are configured to disengage the post section when an external pressing force is applied to the grip surfaces, causing the spring to compress, causing a first rotational movement of the locking bars around the attachment point, causing a second rotational movement of the locking tips in the opposite direction of the first rotational movement, and causing each of the locking tips to disengage the one of the plurality of post slots.

US Pat. No. 10,244,831

TWO-PART WATCH STRAP

1. A two-part watch strap comprising:a clasping part comprising:
a clasping-part watch-attaching end that is proximal to a watch when the two-part strap is attached to the watch;
a clasping end, opposite the watch-attaching end of the clasping part that is distal from the watch when the two-part strap is attached to the watch;
a clasping-part strap, band, or bracelet portion that extends between the watch-attaching end of the clasping part and the clasping end of the clasping part in a clasping-part longitudinal direction; and
a groove arranged in the clasping-part strap, band, or bracelet portion that extends completely through the clasping-part strap, band, or bracelet portion in a thickness direction orthogonal to the clasping-part longitudinal direction; and
a clasped part comprising:
a clasped-part watch-attaching end that is proximal to the watch when the two-part strap is attached to the watch;
a free end, opposite the watch-attaching end of the clasped part, that is distal from the watch when the two-part strap is attached to the watch;
a clasped-part strap, band, or bracelet portion that extends between the watch-attaching end of the clasped part and the free end of the clasped part; and
a protruding portion arranged adjacent to, near, or at the free end of the clasped part, the protruding portion being configured to engage with and at least partially lock into the groove of the clasping part so as to secure the free end of the clasped part to the clasping part;
wherein the clasped part further comprises:
at least one clasped portion configured to be secured to the clasping end of the clasping part to secure the watch to a wrist of a user when the two-part strap is attached to the watch;
wherein the groove of the clasping part has a length equal to or greater than a length of the clasped portion; and
wherein the groove of the clasping part has the length equal to or greater than a length of the clasped portion so that the protruding portion can slide along the groove when the protruding portion is engaged with and at least partially locked into the groove.

US Pat. No. 10,244,830

CLASP MECHANISMS FOR WRISTWATCH BANDS

Google LLC, Mountain Vie...

1. A watch band comprising:a strap; and
a clasp mechanism connected with the strap at a proximal end of the clasp mechanism, the clasp mechanism comprising:
a member defining a channel at a distal end of the clasp mechanism,
a pivot member held in a fixed position with respect to the member defining the channel;
a rocker member configured to rotate about a pivot point defined by the pivot member, the rocker member having a first portion that extends generally away from the pivot member toward the distal end of the clasp mechanism and a second portion that extends generally away from the pivot member toward the proximal end of the clasp mechanism, the rocker member further configured to pivot between:
(i) a first position in which the rocker member covers a portion of the channel sufficient to prevent a spring pin of a watch module from being removed from the channel, and
(ii) a second position in which an end of the rocker member is positioned sufficiently far away from the channel to allow a spring pin of a watch module to be removed from the channel; and
a button affixed to the rocker member, wherein the button is configured to cause the rocker member to pivot from the first position to the second position when pressed.

US Pat. No. 10,244,829

ZIPPER LOCK

Juno Group Pty Ltd, Balg...

1. A locking system for a zipper, the zipper comprising a chain and a slider, the chain being moveable to adopt an open and a closed configuration through movement of the slider with respect to the chain, the zipper comprising a pull tab engaged with the slider for effecting movement of the slider with respect to the chain, the slider having opposing sides which are in contact with the chain in use and opposing faces which are oriented substantially normal to the sides and facing away from one another, the pull tab being engaged with one of the faces of the slider, the opposing face comprising an abutment face, the locking system including a lock member biased into a retaining position in which the lock member retains the slider with respect to the chain by abutting at least a portion of the abutment face of the slider, the locking system including an actuator such that actuation of the actuator allows movement of the lock member into a releasing position.

US Pat. No. 10,244,828

WIDE TOP NARROW BOTTOM TYPE DOUBLE-LAYER ZIPPER FOR LUGGAGE AND ZIPPER SLIDER FOR SAME

GENMORE ZIPPER CORPORATIO...

1. A wide top narrow bottom type double-layer zipper, comprising a top and bottom zipper set, and a zipper slider coupled to said top and bottom zipper set and movable in one of two opposite directions to close or open said top and bottom zipper set, said top and bottom zipper set comprising left and right zipper tapes, top and bottom interlocking coils stitched to opposing top and bottom surfaces of said left and right zipper tapes to form two left series of interlocking teeth and two right series of interlocking teeth, said top and bottom interlocking coils each comprising a filler cord and a polyester coil spirally extended around said filler cord, wherein:the combined width of the interlocked said bottom interlocking coils is smaller than the combined width of the interlocked said top interlocking coils; said top interlocking coils and said bottom interlocking coils have the same spiral pitch; the top and bottom layers of the wide top narrow bottom type double-layer zipper are vertically aligned and sewed;
said zipper slider comprises a top cover panel, an opposing bottom cover panel, opposing left and right guard flanges respectively and perpendicularly located at respective opposite lateral sides of said top cover panel and said bottom cover panel, an upright base center connected between said top cover panel and said bottom cover panel on the middle, a top chamber defined by said top cover panel for accommodating said top interlocking coils and a bottom chamber defined by said bottom cover panel for accommodating said bottom interlocking coils, the width of said bottom cover panel being smaller than the width of said top cover panel, said bottom chamber being relatively narrower and shorter than said top chamber.

US Pat. No. 10,244,827

SAFETY CAR SEAT TIGHTENING DEVICE AND SEAT WEDGE FOR USE IN INSTALLING SAFETY CAR SEATS

4. A tightening device for use in installing child safety car seats comprising:a frame having at least two vertical members extending downward from a top member wherein the top member is in a horizontal position in relation to the at least two vertical members;
at least one ratchet attached to the frame in an elevated position;
said at least two vertical members are notched side members each having notched ends; and
said notched ends engage posts that are attachable to a child safety car seat.

US Pat. No. 10,244,826

APPARATUS FOR SECURING A MARTIAL ARTS BELT

1. An apparatus for securing a knot of a martial arts belt, comprising:a flexible rectangularly-shaped sheet of material consisting of a first panel, a second panel, and a third panel; wherein the first panel and the third panel hingedly fold inwardly toward the second panel; and
means for fastening the first and third panels together when the first panel and third panel are folded inwardly toward to the second panel;
wherein the second panel consisting of a single hole located in a central portion of the second panel;
wherein the first panel, the second panel, and the third panel are configured to encircle the martial arts belt when the apparatus is attached to the martial arts belt,
wherein the hole is configured to allow a portion of the martial arts belt and/or the knot to extend, at least partially, through the hole when the apparatus is fastened to the belt.

US Pat. No. 10,244,825

ADJUSTABLE BELT

1. An adjustable belt for wear about a waist of a person, including:an overlapping portion of the belt which is folded back to form a buckle loop, the overlapping portion having a length;
a buckle captured by the buckle loop;
a tongue at a region distal to the buckle, the tongue including a series of buckle holes which the buckle engages to secure the belt in a belt loop; and
a securing mechanism to secure the overlapping portion of the belt folded back along an overlapped portion of the belt, the securing mechanism including at least one stud and at least one hole configured for engagement with the, or each, stud, wherein the belt has a length which is adjustable by varying the length of the overlapping portion so that lengthening the overlapping portion shortens the length of the belt by half the length of the overlapping portion, wherein the, or each, stud includes a head arranged at an end of an elongate member; wherein the, or each, stud is receivable in the, or each, hole; and wherein the, or each, hole includes an elongate slot configured to receive and secure the elongate member, the elongate slot extending from a substantially circular opening of the, or each, hole.

US Pat. No. 10,244,824

HEEL PROTECTOR

GOGO HEEL, LLC, Encinita...

1. A shielding cup configured to be attached to a stiletto heel tip, the cup comprising:an open top;
a bottom base having an inner surface and an outer surface;
sidewalls extending from the bottom base to the open top, the sidewalls having an inner surface and an outer surface; and
an inner cavity bounded by the inner surface of the sidewalls and the inner surface of the bottom base, the inner cavity configured to receive the heel tip through the open top,
wherein a portion of the sidewalls adjacent to the open top is configured to be more flexible than a portion of the sidewalls adjacent to the bottom base by tapering the sidewalls from the bottom base to the open top such that a thickness as measured from the inner surface of the sidewall to the outer surface of the sidewall of the portion of the sidewalls adjacent to the open top is smaller than a thickness as measured from the inner surface of the sidewall to the outer surface of the sidewall of portion of the sidewalls adjacent to the bottom base, and
wherein a size of the inner cavity adjacent to the open top is not greater than a size of the inner cavity adjacent to the bottom base in a relaxed configuration when the shielding cup is not attached to the heel tip.

US Pat. No. 10,244,823

SHOE HEEL CUP PROTECTION DEVICE

Model Behaviour (Aust) Pt...

1. A unitary shoe heel accessory comprising:a base portion comprising a ground contacting surface and an opposing heel pad contacting surface; and
a resilient shoe heel engaging portion which extends upwardly from the base portion and comprises a circumferential sidewall that defines a bore therein, wherein inner surfaces of the side walls comprise a plurality of equispaced resilient ribs projecting therefrom, the resilient ribs configured for receiving and retaining a shoe heel within the bore,
wherein the heel pad contacting surface is centrally located at a base of the bore and wherein the base portion further comprises a plurality of furrows equispaced around the heel pad contacting surface whereby each of the resilient ribs extends upwardly from a floor of a respective furrow, and
wherein each furrow is deep enough such that a lowermost shoe heel contacting portion of each resilient rib is deflectable by a shoe heel within the bore.

US Pat. No. 10,244,822

LACE ROUTING PATTERN OF A LACING SYSTEM FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A lacing system for an article of footwear with a tensioning assembly, the lacing system comprising:a lace having comprising a first lace segment and a second lace segment;
wherein the first lace segment has a first end and a second end, the first end configured to be attached to an upper of the article of footwear on one of a medial side and a lateral side of the upper, and the second end configured to be connected to the tensioning assembly;
wherein the second lace segment has a first end and a second end, the first end configured to be attached to the upper of the article of footwear on one of the medial side and the lateral side of the upper, and the second end configured to be connected to the tensioning assembly; and
a plurality of lacing guides that are made of a closed tubular material, the plurality of lacing guides including at least a first lacing guide and a second lacing guide, the first lacing guide crossing over and overlapping the second lacing guide, the first lace segment extending through the first lacing guide and the second lace segment extending through the second lacing guide, the first lacing guide and the first lace segment together forming a first routing pattern, and the second lacing guide and the second lace segment together forming a second routing pattern;
wherein the lacing guides are positioned in a lacing area, the lacing area configured to extend from a throat opening of the article of footwear in a longitudinal direction towards an area proximate to a forefoot region of the article of footwear and between a medial edge on the medial side of the upper and a lateral edge on the lateral side of the upper;
wherein a total closure distance between the medial edge and the lateral edge of the lacing area according to the first routing pattern is approximately equal to a total closure distance between the medial edge and the lateral edge of the lacing area according to the second routing pattern.

US Pat. No. 10,244,821

SOLE STRUCTURE FOR AN ARTRICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A sole structure of an article of footwear, the sole structure comprising:a flexure element having:
(a) a central portion located between a first ground-facing region and a second ground-facing region, the central portion having a downwardly concavely-curved plate region, and
(b) first and second flanges extending upward from the first and second ground-facing regions, respectively;
an upper support element positioned above the central portion, between the first and second flanges of the flexure element, and below upper edges of the first and second flanges of the flexure element; and
an outsole positioned beneath the flexure element,
wherein the upper support element is configured to move vertically relative to the first and second flanges when a vertical compressive load is first applied to the upper support element, and
wherein the central portion, the first ground-facing region, the second ground-facing region, and the first and second flanges are integrally formed of a single material as a single layer.

US Pat. No. 10,244,820

REINFORCING SHANK ARRANGEMENT FOR FOOTWEAR SOLE STRUCTURE

NIKE, Inc., Beaverton, O...

1. A sole component for an article of footwear, the sole component comprising:a baseplate including a heel region and a forefoot region;
an arrangement of ground engaging members extending from the baseplate; and
a reinforcing shank arrangement including a plurality of reinforcing strips formed of a different material than portions of the baseplate adjacent the reinforcing strips, the reinforcing shank arrangement including a first reinforcing strip extending in a direction from the heel region toward the forefoot region and toward a medial side of the baseplate, a second reinforcing strip extending from the heel region toward the forefoot region and toward a lateral side of the baseplate, and a third reinforcing strip disposed between the first reinforcing strip and the second reinforcing strip and extending from a junction of the first reinforcing strip and the second reinforcing strip toward the forefoot region.

US Pat. No. 10,244,819

APPARATUS AND METHOD FOR SECURING AN UPPER TO A SOLE

NIKE, Inc., Beaverton, O...

1. A manufacturing apparatus for an article of footwear, comprising:first and second pairs of clamps that secure in place a sole of the article of footwear, the first pair of clamps cooperating to secure a ball region of the sole and the second pair of clamps cooperating to secure a heel region of the sole; and
first and second perimeter deforming implements that, when initiated, apply pressure to a bottom surface of the secured sole causing a lateral rim and a medial rim of a perimeter of a top surface of the secured sole to open outwardly from a central longitudinal axis of the sole.

US Pat. No. 10,244,818

VARIABLE HARDNESS ORTHOTIC

Clemson University Resear...

1. An orthotic layer that exhibits a variable hardness across the orthotic layer, the orthotic layer comprising an upper surface and a lower surface and a plurality of cells arranged in a predetermined pattern across the orthotic layer, wherein every cell of the plurality of cells extends between the upper surface and the lower surface and every cell of the plurality of cells is open at either the upper surface or the lower surface of the orthotic layer, the plurality of cells including a first portion of cells in a first region of the orthotic layer, each cell of the first portion of cells having a first void volume, the plurality of cells including a second portion of cells in a second region of the orthotic layer, each cell of the second portion of cells having a second void volume, the first region having a first hardness and the second region having a second, different hardness as determined according to ASTM D 2240-05.

US Pat. No. 10,244,817

SKI BOOT

ROSSIGNOL LANGE S.R.L., ...

1. Ski boot with rigid shell comprising:a lower shell,
a cuff articulated in rotation to the lower shell,
at least one connecting ring connecting the cuff to the lower shell,
the connecting ring being inserted in a first opening in the lower shell, and in a second opening in the cuff,
the connecting ring comprising:
a locking surface collaborating with a corresponding locking surface which is part of a surface of the first opening in the lower shell, so as to prevent the connecting ring from rotating relative to the lower shell, and
a rotation surface collaborating with the second opening in the cuff, so as to guide the rotation of the cuff relative to the lower shell about the rotation surface.

US Pat. No. 10,244,816

SPORTS SHOE INNERBOOT

ROSSIGNOL LANGE S.R.L., ...

1. Comfort element for a sports shoe innerboot, comprising a thermoformable foam having at least two zones of different thicknesses formed from a same initial foam material of the thermoformable foam,wherein the at least two zones form at least one face of the comfort element, the at least one face having areas in relief,
wherein the comfort element is adapted to form at least part of a layer of a wall of the sports shoe innerboot,
wherein a product of the thickness times the density of the comfort element differs between the at least two zones of different thicknesses.

US Pat. No. 10,244,815

FOOTWEAR SOLE STRUCTURE WITH CARRIER AND FRAME

NIKE, Inc., Beaverton, O...

1. A sole structure for an article of footwear, comprising:a carrier having a bottom side and a top side, the carrier comprising a portion located in a forefoot region of the sole structure, a portion located in a midfoot region of the sole structure, and a portion located in a heel region of the sole structure; and
a frame attached to the carrier top side and comprising interconnected walls defining a plurality of cells, and wherein
at least some of the cells are varied with respect to at least one of size, shape, alignment, and spacing, and at least some of the walls are varied with respect to wall height and wall thickness, so as to define one or more regions of increased stiffness in the frame and one or more regions of reduced stiffness in the frame,
at least parts of the portions of the carrier extend under the cells, and
the one or more regions of increased stiffness comprise a region of increased stiffness about multiple transverse axes, the region of increased stiffness about multiple transverse axes extending through forefoot and midfoot portions of the frame and comprising a first branch extending through a first metatarsal region, a second branch extending through a fifth metatarsal region, and a midfoot branch extending from a junction of the first and second branches and through the midfoot portion of the frame.

US Pat. No. 10,244,814

MODULAR SHOE WITH INTERCHANGEABLE COMPONENTS AND METHOD OF ATTACHMENT

Flop Girl LLC, Mount Kis...

1. A modular shoe assembly, comprising:a sole comprising a front end, a heel end, a top surface, and a bottom surface; and
a heel connected to the bottom surface of the sole, at the heel end;
wherein the heel further comprises:
a base, the base having a heel upper surface connected to the bottom surface of the sole, a heel bottom surface on an opposite side of the base from the upper surface, a front, a back, and lateral sides, wherein the front side of the base has routed corners; and
a heel band removably connected to the base,
wherein the heel band has two ends, and a rib on an interior surface of the heel band at each end, so that each of the ribs sit in the routed corners at the front of the base.

US Pat. No. 10,244,813

SANDALS WITH BIOMECHANICAL FOOT SUPPORT

VIONIC GROUP LLC, San Ra...

1. A footwear product comprising:a sole having a top surface and a bottom surface, the top surface comprising a foot supporting surface including a forefoot supporting contour, a raised medial contour and a concave heel cup, the bottom surface incorporating an oval-shaped cavity under the medial contour, the oval-shaped cavity having a major axis aligned in a longitudinal direction of the sole and a minor axis aligned in a traverse direction of the sole, wherein the oval-shaped cavity permits the sole to deform or collapse from the top when a user walks;
wherein the sole has a maximum thickness at a medial edge of the medial contour, and wherein the oval-shaped cavity has a depth at its lowest point of between ¼ and ? of the maximum thickness of the sole;
a strap anchored to the sole via at least one anchor point.

US Pat. No. 10,244,812

APPARATUS FOR DISPERSING IMPACT FORCES

Newtonoid Technologies, L...

1. A system for mitigating an impact force, the system comprising a helmet having a face mask attached thereto, the face mask comprising a face mask bar extending from a first side of the helmet to a second side of the helmet defining a length, the face mask bar comprising first and second bar portions each extending along the entirety of the length;wherein:
the first portion and the second portion are separated by a gap and held together via a biasing member; and
a force received by the first portion is at least partially transferred to the second portion via the biasing member;
a fraction of the transferred force is returned to the first portion, the fraction being less than the force received.

US Pat. No. 10,244,811

SUSPENSION LOCKING TAB

Honeywell International I...

1. A hardhat comprising:a shell having an outer surface and an inner surface;
a suspension comprising a horizontal band that is configured to at least partially encircle a user's head;
a hanger connected to the suspension for securing the suspension to the shell, the hanger further comprising:
a hook at a first lower end of the hanger;
a latching surface located towards a middle of the hanger;
a lever arm at a second upper end of the hanger;
a mount formed on the inner surface of the shell, the mount having a mount platform toward a first lower end of the mount and a ledge surface at a second upper end of the mount;
wherein the hanger is configured to securely engage the mount with the latching surface of the hanger being in frictional engagement with the ledge surface of the mount and the mount platform being in direct facing relation with a surface on the hook, thereby positionally securing the hanger to the shell,
and further wherein the first lower end of the hanger is the lower end thereof when the suspension is secured to the shell and the shell is in an upright position.

US Pat. No. 10,244,810

SMART HELMET

1. A device comprising a processor, coupled to a memory, that executes or facilitates execution of one or more executable components, comprising:a helmet element comprising an outer shell layer and an interior protective layer, wherein the interior protective layer comprises a set of inflatable cells;
a gas delivery system configured to adjust a pressure condition within a first subset of inflatable cells of the set of inflatable cells, wherein a first set of high pressure valves and a second set of low pressure valves of the gas delivery system are connected to a set of high pressure lines and low pressure lines respectively that connect to base portions of the set of inflatable cells via first stud members connected to the base portions, wherein the gas delivery system further comprises:
a high pressure system comprising the set of high pressure lines connected to the set of inflatable cells and the first set of valves, wherein the high pressure system is configured to deliver a high pressure gas flow through a subset of high pressure lines via a first subset of valve members and into the first subset of inflatable cells based on a predicted impact location;
a low pressure system comprising the set of low pressure lines connected to the set of inflatable cells and the second set of valves, wherein the low pressure system is configured to deliver a low pressure gas flow through a subset of low pressure lines via a second subset of valve members and into a second subset of inflatable cells based on a surrounding region of the predicted impact location, wherein the surrounding region covers a greater surface area of the interior protective layer than the predicted impact location; and
a control system configured to control a position of the first subset of valves and the second subset of valves of the gas delivery system, a regulation of a gas flow within the first set of valves and the second set of valves based on the position, and one or more sensors embedded within the helmet element, wherein the one or more sensors are configured to detect a set of data associated with an environment of the device.

US Pat. No. 10,244,809

HELMET FOR ATTENUATING IMPACT EVENT

Linares Medical Devices, ...

1. A helmet, comprising:a rigid shell adapted to be supported over a wearer's head;
at least one deflecting and force absorbing portion extending from and along a lower rim edge of said rigid shell, each of said deflecting and force absorbing portion having, in cross section, a cupped interior, coiled springs extending from said cupped interior and securing to said rigid shell so that that an extending bottom rim edge of said rigid shell is positioned within the cupped interior and each of said deflecting and force absorbing portion projecting both interiorly and exteriorly of said rigid shell;
an array of interior head supporting and force absorbing portions secured to interior locations of said rigid shell and including an upper most collapsible portion adapted to support a top of the user's head, a cushioning ring array extending around an intermediate perimeter of said rigid shell and adapted to support a crown of the wearer's head, and a semi-circular support adapted to support a base of the wearer's head along a lower rear of said rigid shell and to provide a rear neck support; and
upon the wearer experiencing a head impact force exerted on said rigid shell from any direction, bending of a neck of the wearer adapted to being limited by contact between each of said deflecting and force absorbing portion projecting exteriorly and any of a shoulder or upper back of the wearer, concurrent with said array of interior head supporting and force absorbing portions each providing individual and varied controlled collapsing as determined by an angle and direction of the head impact force.

US Pat. No. 10,244,808

THREE-DIMENSIONAL ELECTRIC FIELD SENSOR IN HARD HATS

1. A three-dimensional electric field sensor constructed and arranged to fit a hard hat, wherein the sensor is parallelepipedally-shaped and centrally located on a front face of the hard hat, and comprising:a) a front face and a rear face, the rear face facing towards and being affixed to the hard hat, and the front face facing outwardly away from the hard hat;
b) an outer shell covering the sensor, having a symmetrical round-edged parallelepipedal shape, and fitting over the entire length of the three-dimensional electric field sensor, comprising;
a parallelepipedally-shaped outer shell base (2A), having a rear face facing towards the hard hat and fitting over the entire length of the sensor rear face, a hollow front face; and
a parallelepipedally-shaped outer shell cover (2B), having a front face and a hollow rear face facing towards the hard hat, the rear face fitting to the front face of the outer shell base;
c) a parallelepipedally-shaped inner shell (3), being a capacitive sensor, forming a single unit, contained within the outer shell and located on the rear face of the outer shell cover (2B), the inner shell comprising:
a parallelepipedally-shaped inner shell base (3A), having a hollow front face and a rear face; and
a rectangular-shaped inner shell cover (3B) fitting atop the front face of the inner shell base (3A);
d) a rectangular-shaped electronic board (4), vertical and centrally located inside the inner shell (3), the electronic board configured for assisting controlling of the sensor, and the inner shell shielding the board from magnetic and electronic field exposure;
e) a parallelepipedally-shaped battery and adapter assembly (5) providing a power supply, located inside the outer shell (2) on a central lower surface of the outer shell cover (2B), the assembly comprising:
a parallelepipedally-shaped adapter (5A) located between a lower surface of the rear face of the inner shell base (3A) and a lower surface of the rear face of the outer shell cover (2A);
a cylindrically-shaped battery (5B), fitted horizontally and parallelly along and to a bottom side of the adapter (5A); and
f) a cylindrically-shaped warning buzzer (6), fitted adjacent to the battery and adapter assembly, between a lower surface of the rear face of the inner shell base (3A) and a lower surface of the rear face of the outer shell cover (2A), the buzzer providing an audible warning sound when triggered by the sensor detecting proximity to medium voltage conductors.

US Pat. No. 10,244,807

AIRWAY OPENING DEVICE FOR HELMETS AND A HELMET COMPRISING THE SAME

INOVYTEC MEDICAL SOLUTION...

1. A helmet mounted safety device for ensuring an open airway, comprising right and left mandible engaging sections,wherein each of said mandible engaging sections comprises:
i) an adjustable and angled airway opening member having a first element configured to contact a bottom of a corresponding mandible angle of a helmet wearer, and a second element which is angularly spaced from said first element and which is configured to contact the corresponding mandible angle proximate to a junction with a ramus and to assure opening of the airway of the helmet wearer;
ii) an element configured with an anteroposteriorly extending groove;
iii) means connected to said airway opening member and passing through said groove, to urge anteroposterior displacement of said airway opening member; and
iv) a connecting element for connection to an area of an interior face of a corresponding inferior region side portion of a helmet that is sufficiently spaced from a corresponding mandible of the helmet wearer to facilitate engagement between said airway opening member and the corresponding mandible angle only following selective anterior displacement of said airway opening member that applies a force to the corresponding mandible angle to cause jaw opening and ensure an open airway.

US Pat. No. 10,244,806

MAGNETIC SNAP FASTENER

1. A magnetic fastener for securing two pieces of sheet material together, the magnetic fastener comprising:a receiving element for affixing to a first sheet of material, the receiving element having a front face, a rear face and a central opening extending through the receiving element, the receiving element further including a first planar magnet having a front surface and rear surface recessed within the central opening of the receiving element such that the rear surface of the first planar magnet is coplanar with the rear face of the receiving element and where a recess is created in the central opening on the front face of the receiving element;
an insertion element for affixing to a second sheet of material, the insertion element having a front face, a rear face and a second central opening extending through the insertion element, the insertion element having a second planar magnet oriented in opposite polarity to that of the first planar magnet inserted into the second central opening of the insertion element and protruding from the front face of the insertion element, where the second planar magnet has a front surface and back surface and where the back surface of the second planar magnet is coplanar with the rear face of the insertion element, and where the second planar magnet is sized to fit within the recess in the central opening on the front face of the receiving element, such that when the second planar magnet is in proximity to the recess in the central opening of the receiving element, the second planar magnet of the insertion element is induced to enter and substantially fill the recess of the receiving element, securing the two elements together through a magnetic attraction between the first planar magnet and the second planar magnet,
where the receiving element and the insertion element include areas surrounding the first planar magnet and the second planar magnet that are nonmagnetic and where a nonmagnetic area of the insertion element is perforated by a plurality of peripheral holes sized to permit a passage of thread for a purpose of affixing the insertion element to the second sheet of material; and
where the recess in the receiving element is substantially a same depth as a distance that the second planar magnet protrudes from the front face of the insertion element, where the front face of the receiving element and the front face of the insertion element are brought into direct contact with one another, creating closure of the first and second sheets of material.

US Pat. No. 10,244,805

CONVERTIBLE BIKINI TOP AND APPARATUS FOR CONVERSION OF A BIKINI TOP

1. A method of securing a string bikini, the string bikini having a panel with first and second strings extending outwardly therefrom, the method comprising the steps of:providing a bead having intersecting first and second passageways extending therethrough, said first passageway being perpendicular to said second passageway;
threading said first string through said first passageway of said bead;
threading said second string through said second passageway of said bead such that said first string frictionally engages said second string so as to hold said first string in a position relative to said second string, and such that said first string and said second string engage inner walls of said bead.

US Pat. No. 10,244,804

GARMENT VENT

BERGHAUS LIMITED, London...

1. A garment comprising:a vent path extending from an outside of the garment to an interior of the garment,
an upper outer panel having a lower end portion,
a lower inner panel having an upper end portion,
the lower end portion of the upper outer panel overlapping the upper end portion of the lower inner panel so as to form a vent opening between the lower end portion and the upper end portion,
a gutter formed as a downward fold from one of the panels, the gutter extending from the fold into the vent opening,
the vent opening being opened above the upper end portion of the lower inner panel,
an access opening from the vent opening into the interior of the garment, and
wherein the vent path is unobstructed from the outside of the garment, through the vent opening, around the gutter and through the entire access opening into the interior of the garment, wherein the upper outer panel and the lower inner panel are operatively engaged with each other at opposite ends of the access opening, such that an air flow with a continuous width equal to an entire width of the access opening between the opposite ends of the access opening can pass through the access opening into the interior of the garment.

US Pat. No. 10,244,803

ATHLETIC SHORTS GARMENT APPARATUS WITH IMPROVED INTERFEMORAL GUSSET AND SURROUNDING MODESTY PANEL

1. An athletic shorts garment apparatus with improved interfemoral gusset and surrounding modesty panel comprising:a) a waistband complex having an anterior face connected to a posterior face along a left waistband seam and a right waistband seam, said waistband complex having a top shorts complex seam edge and a bottom shorts complex seam edge;
b) a shorts garment complex having a left leg structure and a right leg structure connected along a central anterior seam and a central posterior seam, said shorts garment complex having a top shorts garment complex seam edge, a left leg structure bottom shorts garment seam edge and a right leg structure bottom shorts garment seam edge, said left leg structure having an anterior left interfemoral gusset seam edge and a posterior left interfemoral gusset seam edge, said right leg structure having an anterior right interfemoral gusset seam edge and a posterior right interfemoral gusset seam edge, said top shorts garment complex seam edge is attached to the bottom shorts complex seam edge of the waistband complex;
c) an improved interfemoral gusset comprising two continuous panels of a same shape in a double-layered arrangement connected at boundary edges, wherein the improved interfemoral gusset is attached to the shorts garment complex along the anterior right interfemoral gusset seam edge, the posterior right interfemoral gusset seam edge, the anterior left interfemoral gusset seam edge, and the posterior left interfemoral gusset seam edge, said improved interfemoral gusset having an oblong hexagonal shape;
d) a modesty panel having a top modesty panel seam edge and a bottom modesty panel hem edge, where said top modesty panel seam edge is attached to the bottom waistband complex seam edge;
e) an angled left leg cuff piece having a fold forming a dual layer cuff attached to the left leg structure bottom shorts garment seam edge and attached to the improved interfemoral gusset and having a diameter at a bottommost edge that is smaller than a diameter at a topmost edge of the angled left leg cuff piece that is attached to the left leg structure bottom shorts garment seam edge; and
f) an angled right leg cuff piece having a fold forming a dual layer cuff attached to the right leg structure bottom shorts garment seam edge and attached to the improved interfemoral gusset and having a diameter at a bottommost edge that is smaller than a diameter at a topmost edge of the angled right leg cuff piece that is attached to the right leg structure bottom shorts garment seam edge.

US Pat. No. 10,244,802

APPAREL ARTICLE WITH INTEGRAL PRE-WORN DESIGN ELEMENTS

1. An apparel article comprising:a body portion made of a new and finished apparel article;
at least one pre-worn piece taken from an indicia-bearing apparel article that was previously worn by an athlete at a sporting event held on a particular date and at a particular place, the at least one pre-worn piece having an outer perimeter and being affixed onto the apparel article so that the entire pre-worn piece covers a portion of the apparel article and is fastened to the apparel article along the outer perimeter of the pre-worn piece; and
a provenance portion located on the finished apparel article and containing an official apparel authentication issued by an official authenticating authority for the particular sport associated with the at least one pre-worn piece and further having a name of the athlete or team, a name of the official authenticating authority for the particular sport associated with the at least one pre-worn piece, and a listing of at least one of the event, date and particular place associated with the at least one pre-worn piece to create an authenticated sports memorabilia item that can be instantaneously identified down to memorabilia details including a specific athlete or team, the authenticating authority, and at least one of the event, date and place associated with the at least one pre-worn piece thereby providing a readily visible provenance portion that not only markets the memorabilia item to the consumer due to the memorabilia details provided thereon, but also allows the consumer to quickly search through a plurality of apparel articles to instantaneously locate a specific item being sought by the consumer and then display the memorabilia details when wearing the specific item.

US Pat. No. 10,244,800

BRA POCKET SYSTEM

Sherrywear LLC, Hilton H...

1. A pocket bra assembly comprising:a strap assembly including a chest strap and shoulder straps, the chest strap having a front portion configured to be positioned on a front of a user, and a back portion configured to be positioned on a back of the user, the shoulder straps each having a front portion configured to be positioned on the front of the user, and a back portion configured to be positioned on the back of the user;
a bra portion, the bra portion configured to provide support and shape breasts of the user, the strap assembly being attached to the bra portion whereby the strap assembly holds the bra portion to the user, with the chest strap extending from a first side of the bra portion towards the user's back and extending from a second opposite side of the bra portion towards the user's back;
a back pocket formed entirely of stretchable fabric positioned on the back portion of at least one of the chest strap and shoulder straps, the back pocket having an opening formed that is biased in a closed position at rest, providing access to a pocket interior; and
an item positioned within the back pocket.

US Pat. No. 10,244,799

SOCK STORAGE AND ORGANIZING APPARATUS

1. A sock storage and organizing apparatus comprising:an attachment portion having:
an arcuate inner edge disposed for hooking engagement around an object;
a lowermost portion;
an obverse surface disposed upon one side of the attachment portion;
a reverse surface disposed upon the other side of the attachment portion;
a hook member perpendicularly disposed upon the reverse surface at the lowermost portion; and
a depending portion comprising:
a looped drawstring member disposed for hanging engagement upon the hook member, said looped drawstring member presenting each of a pair of strands when depended from the hook member, an apex at contact with the hook member, and a nadir distally delimited therefrom;
a plurality of slidable buckle members, each of said plurality of slidable buckle member comprising:
a discoid body;
a pair of apertures disposed in parallel relation transversely through the discoid body;
a depressible portion; and
a sprung hasp member disposed interior to the discoid body in operational communication with the depressible outer portion, said sprung hasp member disposed against the action of a spring member to frictionally engage against each of the pair of strands of the looped drawstring member until the depressible portion is depressed;
wherein each of the plurality of slidable buckle members is slidable upon the looped drawstring member when each corresponding depressible portion is depressed, and each of the plurality of slidable buckle members frictionally engages the looped drawstring member when each corresponding depressible portion is released, whereby a user is enabled to slidably reposition each of the plurality of slidable buckle members along the length of the looped drawstring member to selectively engage against an item of apparel maintained between each of the pair of strands of the looped drawstring member and at least one of the plurality of slidable buckle members at the nadir, and at least two of the plurality of slidable buckle members above the nadir.

US Pat. No. 10,244,798

UNDERGARMENT AND GUSSET THEREFOR

The Underwares Group, LLC...

1. A lower body garment comprising:a body including a protected portion configured to cover a protected region of a wearer and an unprotected portion configured to cover an unprotected region of the wearer outside of the protected region of the wearer, the body having a front face and a rear face opposite the front face, and a crotch portion extending between the front face of the body and the rear face of the body;
a gusset located on the body and configured to substantially cover the protected region of the wearer and at least a portion of the front face, the crotch portion, and the rear face, the gusset comprising:
two side edges, a top front edge, and a rear edge that collectively form an outer edge that defines an outline of the gusset, the top front edge being within the front face of the body, the gusset extending to the rear edge located at the rear face of the body;
a transverse axis bisects an elongated length of the gusset, wherein a portion of the gusset bound by the transverse axis, a first portion of each of the side edges and the top front edge defines a front area of the gusset, and a portion of the gusset bound by the transverse axis, a second portion of each of the side edges and the rear edge defines a rear area of the gusset, the front area and the rear area both extending from the crotch portion and to the outer edge; and
the front area of the gusset being larger than the rear area of the gusset and wherein the rear area of the gusset is located near the rear face of the body, the front area of the gusset is located near the front face of the body, and the rear face of the body includes more surface area than the front face of the body.

US Pat. No. 10,244,797

SHIRT WITH FLIP-UP FRONT PANEL

LOGAN FLIP UP LIMITED, M...

1. A garment to be worn by a person, comprising:a base garment comprising front and back panels connected to each other to extend, when worn, respectively in front of and behind a torso of the person, the front and back panels defining an upper collar opening from which the head of the person can protrude and arm openings from which the arms of a person can extend;
a flip up front panel secured to the base garment and having a flip up region movable between a lowered position in which the flip up region covers at least a portion of the front panel to a raised position in which the portion of the front panel is exposed and the flip up region covers a face of the person, the flip up panel having an upper edge portion that is secured to the front panel around a front perimeter of the upper collar opening; and
the flip up region being formed from see-through mesh that obscures the portion of the front panel covered thereby when in the lowered position, and obscures the face of the person covered thereby when in the raised position while permitting the person to see through the mesh.

US Pat. No. 10,244,795

VAPORIZING ASSEMBLY COMPRISING SHEET HEATING ELEMENT AND LIQUID DELIVERY DEVICE FOR AN AEROSOL GENERATING SYSTEM

Altria Client Services LL...

1. A vaporizing assembly for an aerosol generating system, the vaporizing assembly comprising:a heating element at a first position in the vaporizing assembly, the heating element including,
a sheet heating element including,
a plurality of electrically conductive fibers;
a liquid storing portion at a second position in the vaporizing assembly, the first position being longitudinally separated from the first position, the liquid storing portion configured to store a liquid aerosol forming substrate therein; and
a delivery device configured to deliver the liquid aerosol forming substrate from the liquid storing portion to the heating element, the delivery device between the liquid storing portion and the heating element, the delivery device and the heating element defining an air gap therebetween, the delivery device including,
a micropump configured to pump the liquid aerosol forming substrate from the liquid storing portion to the heating element, and the heating element configured to heat the delivered liquid aerosol forming substrate.

US Pat. No. 10,244,793

DEVICES FOR VAPORIZATION OF A SUBSTANCE

Juul Labs, Inc., San Fra...

1. A portable device for generating an inhalable vapor, the device comprising:an elongated main body having a tubular casing extending in a longitudinal direction, the elongated main body containing a vaporization chamber and a battery-powered heater, the battery-powered heater disposed to surround the vaporization chamber, the vaporization chamber disposed proximate to a first end of the elongated main body, the vaporization chamber having a depth in the longitudinal direction that is greater than a width in a lateral direction that is perpendicular to the longitudinal direction;
a mouthpiece disposed proximate to the first end or a second end of the elongated main body, the mouthpiece configured to cover an opening into the vaporization chamber, the second end opposite the first end along the longitudinal direction, removal of the mouthpiece exposing the vaporization chamber, and replacement of the mouthpiece covering the vaporization chamber;
an insulator disposed to surround the battery-powered heater and the vaporization chamber;
a display configured to indicate the temperature of the vaporization chamber;
a microcontroller configured to regulate the temperature of the vaporization chamber; and
a controller configured to select from among a variety of temperature settings.

US Pat. No. 10,244,792

PERSONAL VAPORIZER

1. A personal vaporizer, comprising:an atomizer module having a proximal end and a distal end, and comprising a bowl and a coil arranged in or adjacent the bowl, the bowl configured to accept a wax having an essential oil, the bowl having an open proximal end, the open proximal end disposed at the proximal end of the atomizer module;
a battery assembly, the atomizer module connectable to the battery assembly so that actuation of the battery assembly delivers electrical energy to the coil, causing the coil to heat and vaporize a wax that may be in the bowl; and
a tank module selectively attachable to the proximal end of the atomizer module so that the atomizer module is disposed between the tank module and the battery assembly, the tank module comprising a fluid tank configured to contain a vaporizing liquid therewithin, a distal wall of the fluid tank comprising a fluid delivery hole, an elongated wick extending through and supported by the fluid delivery hole so that a proximal end of the wick is within the fluid tank and a distal end of the wick extends distally from the fluid tank, the wick configured to communicate vaporizing liquid from the fluid tank to the distal end of the wick;
wherein when the tank module is attached to the atomizer module the distal end of the wick extends into the bowl;
wherein when the tank module is removed from the atomizer module, the distal end of the wick is removed from the bowl, and the open proximal end of the bowl is accessible so as to place a wax into the bowl; and
wherein a wax placed in the atomizer module bowl and a vaporizing liquid supplied from the fluid tank to the atomizer module bowl can be simultaneously vaporized within the bowl by the coil so as to form a combined vapor by simultaneously vaporizing both the wax and the vaporizing liquid.

US Pat. No. 10,244,791

VAPORIZER WITH LOGIC NEED BASED MESSAGING PLATFORM

Lunatech, LLC, Encino, C...

1. An electronic vapor device comprising:a device processor operable for controlling the electronic vapor device;
a container for storing a vaporizable material containing nicotine;
a supply sensing component operatively connected to the device processor and controlled in part by the device processor, wherein the supply sensing component is configured to detect a plurality of status data associated with a supply of nicotine-containing vaporizable material stored in the container and transmit detected supply status data to the device processor;
a vaporizing component operatively coupled to the device processor and controlled in part by the device processor, wherein the vaporizing component is in fluid communication with the container for receiving at least a portion of the nicotine-containing vaporizable material therefrom, wherein the vaporizing component is operable to vaporize at least a portion of the nicotine containing vaporizable material received therein to generate a nicotine-containing vapor therefrom;
a vapor outlet coupled to the vaporizing component and configured to receive vapor generated by the vaporizing component, the vapor outlet operable to expel the generated nicotine containing vapor from the electronic vapor device for inhalation of at least a portion thereof by an associated user; a vaporizing status sensing component operatively connected to the device processor and controlled in part by the device processor, wherein the vaporizing status sensing component is configured to detect a plurality of vaporization data associated with vaporization of the nicotine containing vaporizable material and transmit detected vaporization data to the device processor; and a power source operatively coupled to the mixing component and the vaporizing component, wherein the power source is operable to generate a supply of power for operation of at least the mixing component, the vaporizing component, and combinations thereof; wherein the device processor is further operable to: receive at least a portion of the detected supply status data from the supply sensing component; receive at least a portion of the detected vaporization data from the vaporizing status sensing component; and determine, based on at least a portion of the detected supply status data and detected vaporization data, at least one nicotine usage condition and generate a plurality of nicotine consumption data therefrom, wherein the at least one nicotine usage condition comprises a concentration of nicotine present in the vapor generated by the vaporizing component.

US Pat. No. 10,244,790

CIGARETTE HOLDER WITH A MOUTHPIECE

1. A cigarette holder comprising:a mouthpiece and a plurality of chambers;
wherein the mouthpiece is attached to one of the plurality of chambers;
wherein each chamber selected from the plurality of chambers is differentiated from the plurality of chambers by a span of an inner diameter of a chamber cylinder;
wherein the mouthpiece further comprises a mouthpiece cylinder, a screen, and a chamber connection;
wherein the mouthpiece is further defined with a proximal end and an distal end;
wherein the mouthpiece is formed in the shape of a tube;
wherein the chamber connection attaches the mouthpiece to a chamber selected from the plurality of chambers;
wherein the chamber connection further comprises a ratchet rim;
wherein the ratchet rim is a ridge that is formed inside the distal end of the mouthpiece;
wherein the ratchet rim forms a catch surface that runs perpendicular to a centerline of the mouthpiece;
wherein the chamber connection further comprises a chamber plug;
wherein the chamber plug is a tube;
wherein the chamber plug is further defined with a proximal end and a distal end;
wherein the chamber plug further comprises a plurality of latch hooks and a plurality of compression channels;
wherein each individual latch hook is an angled surface that is formed on the proximal end of the chamber plug;
wherein each individual compression channel is a channel formed through a face of the chamber plug; and
wherein each individual latch hook is caught on the catch surface.

US Pat. No. 10,244,789

BEVERAGE CONTAINER ACCESSORY FOR AN ELECTRONIC VAPING DEVICE

1. A beverage container accessory for an electronic vaping device comprises:a beverage container;
a handle bridge;
a mounting hole;
a weighted plate;
the handle bridge being positioned offset from a base of the beverage container;
the handle bridge being laterally connected to the beverage container;
the weighted plate being positioned adjacent to the base of the beverage container;
the weighted plate being centrally mounted to the base of the beverage container;
the mounting hole traversing through the handle bridge;
the mounting hole being positioned parallel to a central axis of the beverage container; and
the mounting hole being positioned offset from the beverage container.

US Pat. No. 10,244,788

FILTER SEGMENT INCLUDING A SUBSTRATE LOADED WITH A SMOKE-MODIFYING AGENT

PHILIP MORRIS USA INC., ...

1. A filter segment for use in a filter of a smoking article, the filter segment comprising:a substrate loaded with menthol solution, the substrate located within a body of the filter segment and formed from a filter plug wrap having an air permeability ranging from about 7,500 Coresta units to about 20,000 Coresta units and a grammage ranging from about 25 g/m2 to about 80 g/m2, and the filter plug wrap capable of absorbing more than 100 percent of its weight of menthol solution, and the substrate including a ball of the filter plug wrap, a pellet of the filter plug wrap, or both a ball of the filter plug wrap and a pellet of the filter plug wrap.

US Pat. No. 10,244,785

THREE-DIMENSIONAL COOKING MACHINE

MICROJET TECHNOLOGY CO., ...

1. A three-dimensional cooking machine, comprising:a control computer for storing an image file of a predetermined food model and outputting a control command corresponding to the image file of the food model; and
a food ingredient laminating device comprising an ink-jet printer, wherein the ink-jet printer is controlled to perform a three-dimensional food laminating operation according to the control command from the control computer, and the ink-jet printer comprises:
a working platform;
a movable carrying mechanism;
at least one printhead for ejecting a food ingredient, wherein the at least one printhead comprises a printhead platform, a food ingredient supply tank and a pressure regulator, wherein the food ingredient supply tank is located over the printhead platform and contains the food ingredient, and an internal pressure within the food ingredient supply tank is adjusted to be maintained at a negative pressure by the pressure regulator, wherein the printhead platform comprises a printhead chamber and plural nozzles, the plural nozzles are located under the printhead chamber, the plural nozzles are in communication with the printhead chamber, and the food ingredient supply tank and the pressure regulator are in communication with the printhead chamber, wherein the plural nozzles eject ink drops configured to be controlled to comply with the following conditions: a volume of each ink drop is in a range between 0.1˜20000 picoliter, a diameter of each ink drop is in a range between 0.05 and 200000 picometer, a volume error of each ink drop is 20%, and an ejection rate of each ink drop is in a range between 0-10000 drops/second; and
at least one base disposed on the working platform, wherein the movable carrying mechanism is located over the working platform, and movable along two horizontal axis directions and a vertical axis direction according to the control command from the control computer, wherein the at least one printhead is supported on the movable carrying mechanism, and freely moved along the two horizontal axis directions and the vertical axis direction to eject the food ingredient from the plural nozzles on the at least one base so as to produce a three-dimensional food product by laminating multiple layers of the food ingredient.

US Pat. No. 10,244,784

ROOT CROP WASHER

1. A root crop washer including a root crop washing apparatus and a stone separator mounted at an inlet of the root crop washing apparatus, the stone separator comprising a frusto-conical separator housing having a side wall which narrows between a top and a bottom of the separator housing, the separator housing having a root crop inlet and a root crop outlet spaced-apart from the root crop inlet at a top of the separator housing, the root crop outlet communicating with the inlet of the root crop washing apparatus, a first liquid stream generator for generating a first liquid stream within the separator housing travelling between the root crop inlet and the root crop outlet for delivery of the root crop from the inlet to the outlet, said first liquid stream generator comprising a vortex generator for swirling liquid within the separator housing for generating a vortex within the separator housing, said first liquid stream generator comprising set of paddles rotatably mounted within the separator housing and operable to impart a swirling motion to water within the separator housing such that the water swirls about a central vertical axis of the separator housing to support the root crop falling through the root crop inlet and swirl the root crop around the side wall of the separator housing between the root crop inlet and the root crop outlet for discharge into the root crop washing apparatus, and the stone separator further includes a second liquid stream generator for generating a second liquid stream within the separator housing travelling upwardly through the separator housing, wherein the separator housing has a waste outlet at a bottom of the separator housing, a waste removal conveyor is mounted below the waste outlet, and the waste removal conveyor is mounted within a water trough, said waste removal conveyor having an outlet end for discharge of material carried by the conveyor outwardly of the water trough.

US Pat. No. 10,244,783

FRUIT PIERCER WITH EXTERNAL DRIVE MECHANISM

Dunkley International, In...

1. A fruit piercer comprising:a frame assembly;
a needle assembly containing at least one needle;
a drum assembly fixed in position within the frame assembly comprising:
a drum configured with a plurality of pockets fixed in position within the frame assembly;
a support bearing;
a hub;
a drive shaft that connects to a the Geneva wheel on the exterior of the frame assembly; and
a plurality of trunnion wheels
a drive assembly comprising:
a source of rotary power;
an eccentric assembly;
a cam shaft;
a gib located on the exterior of the frame assembly;
a Geneva wheel located on the exterior of the frame assembly; and
a hopper assembly comprising:
a hopper;
a hopper shaft;
a hopper cam;
a roller; and
a spring.

US Pat. No. 10,244,781

REFRIGERATED BLANKET FOR COLD PRODUCT TRANSPORT

Walmart Apollo, LLC, Ben...

1. A flexible cooling blanket comprising:a cooling layer assembly comprising:
a first fabric sheet;
a second fabric sheet, the second fabric sheet being operatively coupled to the first fabric sheet along a first folding seam;
a first set of rigid cooling coils disposed between the first and second fabric sheets on a first side of the first folding seam;
a second set of rigid cooling coils disposed between the first and second fabric sheets on a second side of the first folding seam; and
a first flexible tube connecting the first set of rigid cooling coils and the second set of rigid cooling coils, the first flexible tube extending across the first folding seam from the first side of the first folding seam to the second side of the first folding seam;
a heat dissipating layer assembly comprising:
a third fabric sheet;
a fourth fabric sheet, the fourth fabric sheeting being operatively coupled to the third fabric sheet along a second folding seam;
a first set of rigid heat dissipating coils disposed between the third and fourth fabric sheets on a first side of the second folding seam;
a second set of rigid heat dissipating coils disposed between the third and fourth fabric sheets on a second side of the second folding seam; and
a second flexible tube connecting the first set of rigid heat dissipating coils and the second set of rigid heat dissipating coils, the second flexible tube extending across the second folding seam from the first side of the second folding seam to the second side of the second folding seam;wherein the cooling layer assembly and the heat dissipating layer assembly are operatively connected, and the second fabric sheet of the cooling layer assembly is disposed adjacent to the third fabric sheet of the heat dissipating layer assembly; anda compressor operatively connected to the cooling layer assembly.

US Pat. No. 10,244,780

FOOD PRESERVATION SYSTEM

YUAN ZE UNIVERSITY, Taoy...

1. A food preservation system, comprising:a storage cabinet for storing foods;
an electrolytic gas generator in fluid communication with the storage cabinet, wherein the electrolytic gas generator outputs a first gas and a second gas to the storage cabinet for preserving the foods;
a gas detector disposed in the storage cabinet for detecting a gas in the storage cabinet and obtaining a gas concentration information, wherein the gas concentration information comprises a first gas concentration and a second gas concentration; and
a control unit electrically connected to the electrolytic gas generator and the gas detector, wherein the control unit adjusts a voltage value of the electrolytic gas generator according to the gas concentration information, and the control unit controls the type of gases generated by the electrolytic gas generator by adjusting the voltage value, and adjusts the concentrations of the first gas and the second gas in the storage cabinet.

US Pat. No. 10,244,779

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

Senomyx, Inc., San Diego...

1. A liquid composition comprising a sweet enhancer having structural formula (Ia) or (I?a), or a salt or solvate thereof:
and
a phenol-based antioxidant, or a salt or solvate thereof, as a photostabilizer,
wherein:
A is —OR1, —NR1C(O)R2, —NHOR1, —NR1R2, —NR1CO2R2, —NR1C(O)NR2R3, —NR1C(S)NR2R3 or —NR1C(?NH)NR2R3;
B is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl,
C is —OR7, —S(O)bR7, —SO3R7, —C(O)NR7R8, —CO2R7, —NR7CO2R8, —NR7C(O)NR8R9, —NR7C(?NH)NR8R9, —SO2NR7R8, —NR7SO2R8, —NR7SO2NR8R9, —B(OR7)(OR8), —P(O)(OR7)(OR8), —P(O)(R7)(OR8), or heteroaryl;
b are independently 0, 1 or 2;
R1, R2, R3, R7, R8, and R9 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; or alternatively, R1 and R2, R2 and R3, R7 and R8, or R8 and R9, together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring;
R21 is hydrogen, alkyl, substituted alkyl, halo, —CN, —OR25;
R22 is hydrogen, alkyl, substituted alkyl, halo, —CN, —OR27;
R23 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —CN, —OR29, —S(O)fR29, —OC(O)R29, —NR29R30, —C(O)NR29R30, C(O)R29, —CO2R29, —SO2NR29R30, —NR29SO2R30, —B(OR29)(OR30), —P(O)(OR29)(OR30) or —P(O)(R29)(OR30);
R24 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, halo, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, —CN, —OR31, —S(O)gR31, —OC(O)R31, —NR31R32, —C(O)NR31R32, —C(O)R31, —CO2R31, —SO2NR31R32, —NR31SO2R32, —B(OR31)(OR32), —P(O)(OR31)(OR32) or —P(O)(R31)(OR32); or alternatively R23 and R24, taken together with the atom to which they are attached, form a cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, or substituted cycloheteroalkyl ring;
f and g are independently 0, 1 or 2; and
R25, R27, R29, R30, R31, and R32 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; or alternatively R25 and R27, R27 and R29, R29 and R30, R29 and R31, or R31 and R32, together with the atoms to which they are attached, form a cycloheteroalkyl or substituted cycloheteroalkyl ring.

US Pat. No. 10,244,778

METHOD FOR MONITORING COOKING IN AN OVEN APPLIANCE

Haier US Appliance Soluti...

1. A method for monitoring cooking in an oven appliance, comprising:receiving a food item indication at a controller of the oven appliance;
heating a food item within a cooking chamber of the oven appliance, the food item indication corresponding to a type of the food article within the cooking chamber;
drawing cooking vapors or gases from the cooking chamber to a fluid analysis assembly of the oven appliance;
opening a control valve of the fluid analysis assembly in order to mix ambient air about the fluid analysis assembly with the cooking vapors or gases from the cooking chamber, the control valve configured for adjusting ambient air flow in response to the food item indication;
determining a cooking status of the food item within the cooking chamber with the controller of the oven appliance based upon a response pattern of a plurality of fluid sensors of the fluid analysis assembly to the mixture of ambient air and cooking vapors or gases;
exposing the plurality of fluid sensors of the fluid analysis assembly to the mixture of ambient air and cooking vapors or gases, each fluid sensor of the plurality of fluid sensors generating a respective signal during said step of exposing, the respective signal from each fluid sensor of the plurality of fluid sensors corresponding to a different gas, vapor or combination of gases and vapors in the cooking vapors or gases;
establishing the response pattern of the plurality of fluid sensors with a multivariate machine or statistical learning model at the controller of the oven appliance, the multivariate machine or statistical learning model comprising a linear discriminant analysis model, a partial least squares discriminant analysis model or a support vector machine; and
activating an alert with the controller of the oven appliance when the cooking status of the food item within the cooking chamber is a done cooking status.

US Pat. No. 10,244,775

DEVICE AND METHOD FOR DOSING CRYOGENIC LIQUID

Smitten Ventures, Inc., ...

1. A system comprising:a container mount;
a container having a bottom and sides configured to hold ingredients, the container configured to attach to the container mount;
a coolant dosing system configured to provide a controlled amount of coolant to the ingredients in the container; and
first and second beaters configured to mix the ingredients in the container, each of the first and second beaters configured to scrape the ingredients from a surface of the other of the first and second beaters and configured to scrape the ingredients from the sides and the bottom of the container, the first and second beaters being disposed to pass within a distance of each other, the distance being sufficient to cause the first and second beaters to scrape the ingredients from the surface of the other of the first and second beaters.

US Pat. No. 10,244,774

COTTON CANDY PREPARING DEVICE

AGATSUMA CO., LTD, Tokyo...

1. A cotton candy preparing device, comprising:a main body portion;
a rotary pot that is incorporated in the main body portion and that has a pot upper portion and a pot bottom portion, the rotary pot having a rotation shaft and a gear wheel plate attached to the rotation shaft;
a pan portion that is mounted above the main body portion so as to surround at least the pot upper portion,
wherein the pot upper portion is provided above the main body portion so as to project upwards therefrom and the pot upper portion is configured to separate from the pot bottom portion,
wherein the rotary pot has a detecting switch for detecting a cutoff of an electrical connection to a control integrated circuit that is configured to drive a heater or a motor when the pot upper portion is removed from the pot bottom portion;
a pot mounting base portion having a bearing plate at an upper end thereof, wherein the pot mounting base portion is provided at a bottom plate portion of the main body portion to thereby support rotatably the rotation shaft of the rotary pot, wherein the gear wheel plate is fixed to the rotation shaft in such a way that the gear wheel plate faces the bearing plate and is parallel therewith;
three electrode rings each having a circumferential annular shape centered at the rotation shaft, wherein the three electrode rings are provided on an upper surface of the bearing plate;
a plurality of metallic contacts provided on a lower surface of the gear wheel plate so as to be brought into contact with the three electrode rings; and
a power supply switch arranged in series with the detecting switch in a circuit via two electrode rings of the three electrode rings.

US Pat. No. 10,244,773

COTTON CANDY PREPARING DEVICE

AGATSUMA CO., LTD, Tokyo...

1. A cotton candy preparing device, comprising:a rotary pot that is formed of a pot upper portion and a pot bottom portion,
wherein the pot upper portion has a loading port at an upper end thereof and a tubular inner wall below the loading port,
wherein a lower end of the tubular inner wall has a conically shaped expanded inclined portion that expands downwards, and a plurality of plate-shaped ribs are provided on the conically shaped expanded inclined portion so as to project towards a center of the rotary pot,
wherein lower ends of the plate-shaped ribs contact a disc-shaped heating plate provided on a center of an upper end of the pot bottom portion or forms a slight gap between the disc-shaped heating plate and the plurality of plate-shaped ribs,
wherein a ring member is provided on an outer circumference of a lower end of the conically shaped expanded inclined portion at a lower end of the pot upper portion,
wherein the ring member has a bore diameter such that an inner circumference of the ring member overlaps a circumferential edge of the disc-shaped heating plate,
wherein the ring member includes a plurality of first expanded portions that are formed as cutouts in the ring member each extending radially outwards in a fan shape from an inner edge of the bore diameter,
wherein the plurality of first expanded portions each include a second expanded portion that is formed as a cutout in the ring member further radially outward into a fan shape from the bore diameter, and
wherein an interior space and an outer circumferential exterior portion of the rotary pot are allowed to communicate with each other by way of a gap that is formed in an upper surface of the ring member from an outer circumferential end of each second expanded portion.

US Pat. No. 10,244,772

METHOD FOR CREATING LAYERED CHOCOLATE BODY AND CHOCOLATE MOLD FOR CREATION THEREOF

SAGRA, INC., Silverdale,...

1. A mold for forming a chocolate body comprising:a primary platform;
a secondary platform;
a tubular shell;
a shaft;
a lid;
a shaft covering;
a clamping mechanism;
a tilt mechanism;
the secondary platform being connected with the primary platform;
the tubular shell being perimetrically connected with the secondary platform;
the secondary platform being located in between the primary platform and the tubular shell;
the shaft being connected with the secondary platform;
the shaft being encircled by the tubular shell;
the lid being attached to the tubular shell;
the tubular shell being located in between the secondary platform and the lid;
the shaft covering being superimposed onto the shaft;
the tubular shell comprising an inner lateral surface, an outer lateral surface and an elongated slit;
the elongated slit radially traversing through the tubular shell from the inner lateral surface to the outer lateral surface;
the elongated slit longitudinally traversing through the tubular shell from the secondary platform to the lid;
the clamping mechanism perimetrically surrounding the outer lateral surface;
the tilt mechanism being connected with a bottom of the primary platform without being connected with the tubular shell and the clamping mechanism;
the primary platform being located in between the tilt mechanism and the secondary platform; and
the tilt mechanism being perimetrically coincident with the primary platform.

US Pat. No. 10,244,768

METHOD AND APPARATUS FOR PROCESSING SLAUGHTERED POULTRY

Meyn Food Processing Tech...

1. A method of processing poultry conveyed in a slaughter line of a slaughter house, comprising:stunning the poultry;
obtaining noninvasively at the start of said slaughter line an absorption spectrum of blood of the slaughtered poultry for wavelengths between 200 nm and 1000 nm at non-feathered skin or skin parts of the poultry; and
determining, from the absorption spectrum, whether the poultry was alive or dead on arrival at the slaughter house by comparing the absorption spectrum of the blood of the slaughtered poultry with absorption spectrum for deoxygenated blood.

US Pat. No. 10,244,767

FORMATIVE STRUCTURAL CAKE SYSTEM

Cake Effects LLC, Lake W...

1. A mold system comprising:a first mold portion comprising a dimensional feature formed in a wall of the first mold portion, the first mold portion having a periphery and at least one aperture through the wall;
a second mold portion having a periphery, the second mold portion being alignable to the first mold portion so that the periphery of the first mold portion aligns with the periphery of the second mold portion and an interior space is formed between the first mold portion and the second mold portion;
a fill opening in an upper portion of the mold system and connected to the interior space;
an opening in a bottom portion of the mold system and connected to the interior space;
a base plate connected to the bottom portion for sealably connecting the first mold portion and the second mold portion to the base plate; and
an inner portion of an edible composition, the edible composition having an inner portion having a dimensional mass and an outer portion, the inner portion positioned on the base plate and within the interior space so that a cavity is formed between the inner portion and at least a portion of the wall of the mold system forming the interior space, wherein the cavity extends to the base plate.

US Pat. No. 10,244,766

SYSTEM, DEVICE, AND METHOD FOR OVEN TEMPERATURE CONTROL IN TORTILLA AND TORTILLA CHIP PRODUCTION

1. A heat controlled oven system, comprising:a) at least one oven level, comprising:
an oven belt, which is configured to transport food products that are positioned on the oven belt; and
at least one gas burner, which is configured to bake the food products that are transported on the oven belt; and
b) a heat control unit, which is configured to control the at least one gas burner, in order to control a baking temperature of the at least one oven level, wherein the heat control unit is configured to calculate an estimated heat demand to adjust to a temperature set point, using a heat model of the at least one oven level, wherein the heat control unit further comprises:
a processor;
a non-transitory memory;
an input/output component;
a heat modeler, which is configured to store the heat model for the at least one oven level;
a heat manager, which is configured to calculate the estimated heat demand to adjust the at least one oven level to the temperature set point; and
a feedback controller, which is configured to execute a control loop feedback algorithm to calculate an optimized heat demand based on the estimated heat demand;
wherein the heat model further comprises a heat capacity, a general heat loss, a product heat loss, and a heat required to hold a current temperature;
wherein the heat manager calculates the estimated heat demand as the sum of the general heat loss, the product heat loss, and a heat required to change a current temperature.

US Pat. No. 10,244,760

OPHTHALMIC AND CONTACT LENS SOLUTIONS CONTAINING SIMPLE SACCHARIDES AS PRESERVATIVE ENHANCERS

FXS VENTURES, LLC, Salem...

1. A method for providing an ophthalmic solution comprising:contacting an eye with a single-part solution comprising 0.00001 to 10.0 weight percent of a simple saccharide selected from a group consisting of an aldose, a triose, a tetrose, a pentose, a hextose, and a heptose;
at least 0.00001 weight percent of a preservative with a structure given by:

wherein n is a number between 1 and 500 and Z is a divalent bridging group; and
wherein the concentration of chloride in said solution is not more than 0.2 percent by weight.

US Pat. No. 10,244,757

N-CYCLOALKYL-N-{[2-(1-SUBSTITUTEDCYCLOALKYL)PHENYL]METHYLENE}-(THIO)CARBOXAMIDE DERIVATIVES

BAYER CROPSCIENCE AKTIENG...

1. A compound of formula (II) or a salt thereof:whereinn is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3, 4, 5 or 6;
p is 1, 2, 3, 4 or 5;
Z1 is a non-substituted C3-C7-cycloalkyl or a C3-C7-cycloalkyl substituted by up to 10 atoms or groups that can be the same or different and that are selected from the group consisting of halogen atoms, cyano, C1-C8-alkyl, C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkylaminocarbonyl and di-C1-C8-alkylaminocarbonyl;
Z2 and Z3 are independently a hydrogen atom; substituted or non-substituted C1-C8-alkyl; substituted or non-substituted C2-C8-alkenyl substituted or non-substituted C2-C8-alkynyl cyano; isonitrile; nitro; a halogen atom; substituted or non-substituted C1-C8-alkoxy; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C2-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; substituted or non-substituted C1-C8-alkylsulfanyl; substituted or non-substituted C1-C8-alkylsulfonyl substituted or non-substituted C1-C8-alkylsulfinyl; amino; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C1-C8-alkoxycarbonyl; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl or substituted or non-substituted N—C1-C8-alkyl-C1-C8-alkoxy-carbamoyl; or
Z2 and Z3 together with the carbon atom to which they are linked form a substituted or non-substituted C3-C7-cycloalkyl;
Z4 is a halogen atom; hydroxy; cyano; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkenyl C2-C8-halogenoalkenyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; formyl; substituted or non-substituted C1-C8-alkylcarbonyl; carboxy; or substituted or non-substituted C1-C8-alkoxycarbonyl;
each W is independently a halogen atom; nitro; cyano; isonitrile; hydroxy; amino; sulfanyl; pentafluoro-?6-sulfanyl; formyl; formyloxy; formylamino; substituted or non-substituted (hydroxyimino)-C1-C8-alkyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkenyloxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkynyloxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; carboxy; carbamoyl; N-hydroxycarbamoyl; carbamate; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; C2-C8-halogenoalkenyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkynyloxy; C7-C8 halogenoalkynyloxy having 1 to 9 halogen atoms; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C1-C8-alkyl; substituted or non-substituted C4-C7-cycloalkenyl; C4-C7-halogenocycloalkenyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkenyl; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkynyl; substituted or non-substituted bicyclo[2.2.1]heptanyl substituted or non-substituted bicyclo[2.2.1]heptenyl; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonyloxy; C1-C8-halogenoalkylcarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonylamino; C1-C8-halogenoalkylcarbonylamino having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkyloxycarbonyloxy; C1-C8-halogenoalkoxycarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; substituted or non-substituted C1-C8-alkylaminocarbonyloxy; substituted or non-substituted di-C1-C8-alkylaminocarbonyloxy; substituted or non-substituted N—(C1-C8-alkyl)hydroxy carbamoyl; substituted or non-substituted C1-C8-alkoxycarbamoyl; substituted or non-substituted N—(C1-C8-alkyl)-C1-C8-alkoxycarbamoyl; aryl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkenyl that can be substituted by up to 6 groups Q which can be the same or different; C2-C8-arylalkynyl that can be substituted by up to 6 groups Q which can be the same or different; aryloxy that can be substituted by up to 6 groups Q which can be the same or different; arylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; arylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyloxy that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-heteroarylalkyl that can be substituted by up to 6 groups Q which can be the same or different; heteroaryl which can be substituted by up to 4 groups Q; or heteroaryloxy which can be substituted by up to 4 groups Q; or
Z4 and its vicinal substituent W, together with the carbon atom to which they are linked, form a substituted or non-substituted C4-C7-cycloalkyl;
each Y is independently a halogen atom; C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; or substituted or non-substituted C1-C8-alkoxycarbonyl; and
each Q is independently a halogen atom; cyano; nitro; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; or substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl.

US Pat. No. 10,244,756

FUNGICIDAL N-CYCLOALKYL-N-{[ORTHO-(1-SUBSTITUTED-CYCLOALKYL)HETEROARYL]METHYL}(THIO)CARBOXAMIDES

Bayer CropScience Aktieng...

1. A compound of formula (I)wherein:A is a carbo-linked, unsaturated or partially saturated, 5-membered heterocyclyl group that can be substituted by up to four groups R that can be the same or different, provided that A is not a 3-(dihalogenomethyl)-5-halogeno-1-methyl-1H-pyrazol-4-yl group wherein the halogeno atoms are independently a fluoro or chloro atom;
T is O or S;
n is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3, 4, 5 or 6;
p is 1, 2, 3, 4 or 5;
Z1 is a non-substituted C3-C7-cycloalkyl or a C3-C7-cycloalkyl substituted by up to 10 atoms or groups that can be the same or different and that can be selected in the list consisting of halogen atoms, cyano, C1-C8-alkyl, C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkoxycarbonyl, C1-C8-halogenoalkoxycarbonyl comprising up to 9 halogen atoms that can be the same or different, C1-C8-alkylaminocarbonyl and di-C1-C8-alkylaminocarbonyl;
Z2 and Z3 are independently a hydrogen atom; substituted or non-substituted C1-C8-alkyl; substituted or non-substituted C2-C8-alkenyl; substituted or non-substituted C2-C8-alkynyl; cyano; isonitrile; nitro; a halogen atom; substituted or non-substituted C1-C8-alkoxy; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C2-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; substituted or non-substituted C1-C8-alkylsulfanyl; substituted or non-substituted C1-C8-alkylsulfonyl; substituted or non-substituted C1-C8-alkylsulfinyl; amino; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C1-C8-alkoxycarbonyl; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; or substituted or non-substituted N—C1-C8-alkyl-C1-C8-alkoxy-carbamoyl; or
Z2 and Z3 together with the carbon atom to which they are linked can form a substituted or non-substituted C3-C7-cycloalkyl;
Z4 is a halogen atom; hydroxy; cyano; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 5 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 5 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; formyl; substituted or non-substituted C1-C8-alkylcarbonyl; carboxy; or substituted or non-substituted C1-C8-alkoxycarbonyl;
B1 is a carbo-linked unsaturated, monocyclic or fused bicyclic 5-, 6-, 8-, 9-, 10-membered heterocyclyl ring comprising from 1 up to 4 heteroatoms selected in the list consisting of N, O, S; wherein the dotted line between the two adjacent carbons is a single bond, a double bond or an aromatic bond, with the proviso that B1 is not a 1,3-benzodioxolyl group;
each W is independently a halogen atom; nitro; cyano; isonitrile; hydroxy; amino; sulfanyl; pentafluoro-?6-sulfanyl; formyl; formyloxy; formylamino; substituted or non-substituted (hydroxyimino)-C1-C8-alkyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkenyloxyimino)-C1-C8-alkyl; substituted or non-substituted (C2-C8-alkynyloxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; carboxy; carbamoyl; N-hydroxycarbamoyl; carbamate; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; C2-C8-halogenoalkenyloxy having 1 to 9 halogen atoms; substituted or non-substituted C3-C8-alkynyloxy; C2-C8-halogenoalkynyloxy having 1 to 9 halogen atoms; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C1-C8-alkyl; substituted or non-substituted C4-C7-cycloalkenyl; C4-C7-halogenocycloalkenyl having 1 to 9 halogen atoms; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkenyl; substituted or non-substituted (C3-C7-cycloalkyl)-C2-C8-alkynyl; substituted or non-substituted bicyclo[2.2.1]heptanyl; substituted or non-substituted bicyclo[2.2.1]heptenyl; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonyloxy; C1-C8-halogenoalkylcarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbonylamino C1-C8-halogenoalkylcarbonylamino having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkyloxycarbonyloxy C1-C8-halogenoalkoxycarbonyloxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; substituted or non-substituted C1-C8-alkylaminocarbonyloxy; substituted or non-substituted di-C1-C8-alkylaminocarbonyloxy; substituted or non-substituted N—(C1-C8-alkyl)hydroxy carbamoyl; substituted or non-substituted C1-C8-alkoxycarbamoyl; substituted or non-substituted N—(C1-C8-alkyl)-C1-C8-alkoxycarbamoyl; aryl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyl that can be substituted by up to 6 groups Q which can be the same or different; C2-C8-arylalkenyl that can be substituted by up to 6 groups Q which can be the same or different; C2-C8-arylalkynyl that can be substituted by up to 6 groups Q which can be the same or different; aryloxy that can be substituted by up to 6 groups Q which can be the same or different; arylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; arylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkyloxy that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylsulfanyl that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-arylalkylamino that can be substituted by up to 6 groups Q which can be the same or different; C1-C8-heteroarylalkyl that can be substituted by up to 6 groups Q which can be the same or different; heteroaryl which can be substituted by up to 4 groups Q; or heteroaryloxy which can be substituted by up to 4 groups Q;
each Y is independently a halogen atom; C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; or substituted or non-substituted C1-C8-alkoxycarbonyl;
each Q is independently a halogen atom, cyano, nitro, substituted or non-substituted C1-C8-alkyl, C1-C8-halogenoalkyl comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted C1-C8-alkoxy, C1-C8-halogenoalkoxy comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted C1-C8-alkylsulfanyl, C1-C8-halogenoalkylsulfanyl comprising up to 9 halogen atoms that can be the same or different, substituted or non-substituted tri(C1-C8)alkylsilyl, substituted or non-substituted tri(C1-C8)alkylsilyl-C1-C8-alkyl, substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl, or substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; and
R is independently hydrogen atom; halogen atom; nitro; cyano; hydroxy; amino; sulfanyl; pentafluoro-?6-sulfanyl; substituted or non-substituted (C1-C8-alkoxyimino)-C1-C8-alkyl; substituted or non-substituted (benzyloxyimino)-C1-C8-alkyl; substituted or non-substituted C1-C8-alkyl; C1-C8-halogenoalkyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkenyl; C2-C8-halogenoalkenyl having 1 to 9 halogen atoms; substituted or non-substituted C2-C8-alkynyl; C2-C8-halogenoalkynyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxy; C1-C8-halogenoalkoxy having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfanyl; C1-C8-halogenoalkylsulfanyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfinyl; C1-C8-halogenoalkylsulfinyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylsulfonyl; C1-C8-halogenoalkylsulfonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylamino; substituted or non-substituted di-C1-C8-alkylamino; substituted or non-substituted C2-C8-alkenyloxy; substituted or non-substituted C3-C8-alkynyloxy; substituted or non-substituted C3-C7-cycloalkyl; C3-C7-halogenocycloalkyl having 1 to 9 halogen atoms; substituted or non-substituted tri(C1-C8)alkylsilyl; substituted or non-substituted C1-C8-alkylcarbonyl; C1-C8-halogenoalkylcarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkoxycarbonyl; C1-C8-halogenoalkoxycarbonyl having 1 to 9 halogen atoms; substituted or non-substituted C1-C8-alkylcarbamoyl; substituted or non-substituted di-C1-C8-alkylcarbamoyl; phenoxy; phenylsulfanyl; phenylamino; benzyloxy; benzylsulfanyl; or benzylamino,or a salt, an N-oxide, a metal complex, a metalloid complex, an optically active isomer, or a geometric isomer thereof.

US Pat. No. 10,244,754

PICOLINAMIDE N-OXIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY

Dow AgroSciences LLC, In...

1. A compound of Formula I,
wherein:
R1 is hydrogen or C1-C5 alkyl, each optionally substituted with 0, 1 or multiple R6;
R2 is hydrogen, C1-C5 alkyl or cycloalkyl, each optionally substituted with 0, 1 or multiple R6;
R3 is alkyl, cycloalkyl, aryl or heteroaryl, each optionally substituted with 0, 1 or multiple R6;
R4 is hydrogen, halo, hydroxyl, alkyl, or alkoxy;
R5 is alkyl, cycloalkyl, aryl, heteroaryl, alkoxy, aryloxy, heteroaryloxy, each optionally substituted with 0, 1 or multiple R6;
R6 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl, each optionally substituted with 0, 1 or multiple R7;
R7 is hydrogen, alkyl, aryl, acyl, halo, alkoxy, or heterocyclyl; and
R8 is hydrogen or C1-C5 alkyl, each optionally substituted with 0, 1 or multiple R6.

US Pat. No. 10,244,752

HERBICIDAL COMPOSITION

Sumitomo Chemical Company...

1. A herbicidal composition comprising a compound represented by the formula (I):and2,4-D choline salt,
wherein the weight ration of the compound by the formula (I) to 2,4-D choline salt is from 1:0.2 to 1:200.

US Pat. No. 10,244,749

MICROMANIPULATION AND STORAGE APPARATUS AND METHODS

Genea IP Holdings Pty Lim...

1. A method of cryopreservation of biological material using an apparatus including a vessel having a reservoir, wherein said vessel has a channel formed in a portion of said reservoir, said channel including an intermediate restriction dimensioned to resist passage of said biological material but allow passage of liquid treatment solutions, and said channel including a first sub-reservoir at a first end of said restriction and a second sub-reservoir at a second end of said restriction, the method comprisin the steps of:introducing said biological material into the first sub-reservoir of said vessel;
irrigating said biological material with a series of vitrification solutions introduced into the first sub-reservoir and removed from the second sub-reservoir;
removing the vitrification solutions from the second sub-reservoir, leaving a residual volume of liquid surrounding the biological material that is sufficiently small for vitrification; and
vitrifying the biological material and the residual volume of liquid surrounding the biological material within the vessel.

US Pat. No. 10,244,748

METHOD FOR MOTION CONTROL AND/OR REGULATION OF AN AGRICULTURAL DISTRIBUTION DEVICE

HORSCH LEEB Application S...

1. A method for the position-controlled guidance of at least two pivotably movable cantilevered arms of an agricultural distribution machine over a ground surface, wherein the at least two pivotably movable cantilevered arms are each positioned adjacent a middle part, and wherein a relative position of the at least two pivotably movable cantilevered arms in relation to the ground surface is detected and a symmetrical realignment of the at least two pivotably movable cantilevered arms and/or of the distribution machine is carried out through autonomous regulation based on the detected relative position in response to a pivoting motion in relation to the ground surface, wherein the autonomous regulation may be overridden by way of manual control comprising a manually specifiable regulation parameter for at least one of the at least two pivotably movable cantilevered arms, which manually specifiable regulation parameter at least temporarily lifts or pivots at least one of the at least two pivotably movable cantilevered arms, wherein the autonomous regulation is temporarily interrupted by way of manual control for at least one of the at least two pivotably movable cantilevered arms, wherein a positioning of the at least one of the at least two pivotably movable cantilevered arms is carried out in a manually controlled manner during the interruption,wherein at least one angle potentiometer for the detection of an angular position between the middle part and the at least two pivotably movable cantilevered arms is arranged between the middle part and at least one of the at least two pivotably movable cantilevered arms, wherein an actuator that is assigned to an oppositely positioned cantilevered arm is controlled on the basis of the angular position detected by the at least one angle potentiometer;
and wherein a desired position for the at least one of the at least two pivotably movable cantilevered arms in relation to the ground surface is specified in a manually controlled manner during the interruption of the autonomous regulation and is subsequently maintained in a regulated manner over a definable time interval or until termination of manual control.

US Pat. No. 10,244,747

APPARATUS AND METHOD FOR DISCHARGING LIQUID AND/OR SOLID ACTIVE SUBSTANCES

1. An apparatus for spreading liquid and/or solid active agents, comprising:a carrier vehicle;
at least one spray boom arranged pivotably about at least one pivot axis; at least one sensor arrangement for detecting an angular velocity and/or an angular position of the spray boom about the pivot axis in relation to a reference plane and/or in relation to a ground surface;
a control unit operable to process output signals of the at least one sensor arrangement and to generate control signals, wherein the control unit influences or controls, the angular position and/or the angular velocity by at least two coupled control loops;
at least one actuator influencing the present angular position of the spray boom about the pivot axis based in response to control signals from the control unit;
wherein a desired value and/or a desired torque for the at least one actuator is generatable from the output signals of the at least one sensor arrangement by the control unit in an outer control loop;
wherein an actual torque, which moves and/or influences the spray boom, and/or an actual value, which is based on actuator deflections and/or on control signals from the at least one actuator, is detectable in an inner control loop and is used for generating a correction value for achieving the desired torque and/or the desired value; and
wherein the inner control loop takes into account further sensor data comprising an adjustment torque which is induced by the actuator into the spray boom and which is measured or is derived from the interaction of the actuator with the spray boom, and wherein the further sensor data are obtained in immediate connection with control signals of the at least one actuator and/or its detected interaction with the movably suspended spray boom.

US Pat. No. 10,244,746

ARM REST FOR A FISHING POLE

1. An arm rest for a fishing pole comprising:a handle attachment bracket;
said handle attachment bracket having a through rod hole that is configured to accept a fishing pole;
said handle attachment bracket having at least two parallel openings therethrough that are perpendicular to said through rod hole;
a side support handle;
said support handle having complementary holes that align with said at least two parallel holes, and
a U-bolt that passes through said at least two parallel holes to secure said handle attachment bracket to said side support handle.

US Pat. No. 10,244,745

CHUMMING DEVICE

1. A chumming device for bait, comprising:a shaft, said shaft having a first end located opposite a second end, said shaft having a curvature, said first end of said shaft having a plurality of bores, said plurality of bores each have different sized diameters, said plurality of bores are arranged in an ascending diameter size from said first end of said shaft toward said head, whereby, the diameter of each bore increases in size traveling toward the head and is configured to allow flexibility of said chumming device when launching bait from said chumming device, a first bore has a first diameter length, a second bore has a second diameter length, a third bore has a third diameter length, said first diameter length of said first bore is a length greater than said second diameter length of said second bore, said second diameter length of said second bore is a length greater than said third diameter length of said third bore;
a head, said head is connected to said first end of said shaft, said head having a plurality of openings, said plurality of openings are configured to allow water flow while scooping bait from a live well, said head having a top portion, said top portion is configured to launch said bait from said head, said head having a lower portion, said lower portion of said head forming a chamber, said chamber having a chamber opening, said chamber opening having a size great enough to receive said bait, said chamber is configured to retain said bait;
said chamber having a first side wall located opposite a second side wall, said first side wall and said second side wall having said plurality of openings located thereon, said first side wall of said chamber having a first recess bordering said chamber opening and said second side wall of said chamber having a second recess bordering said chamber opening, said chamber having a lip located opposite a protruding structure, said lip and said protruding structure having said plurality of openings located thereon, said lip extends up from said first end of said shaft, said lip is located between said recess of said first sidewall and said recess of said second sidewall, said lip extends beyond said recess of said first sidewall and said recess of said second sidewall, said lip does not extend beyond an end of said protruding structure, said protruding structure extending beyond said chamber, said protruding structure is configured to align said bait to be launched in a direction by a force of a user; and,
a handle, said handle is connected to said second end of said shaft, said secondary end of said shaft having an anchoring recess located in an opposite direction of said chamber opening, said anchoring recess is located on an end of said handle, said anchoring recess is configured to interlock with a rod holder.

US Pat. No. 10,244,744

GEAR MECHANISM FOR A FISHING REEL

Shimano Inc., Osaka (JP)...

1. A gear mechanism for a fishing reel, comprising:a drive gear having a gear with a prescribed diameter and a drive gear shaft configured to be rotated together with the gear and having a smaller dimension than the prescribed diameter of the gear;
a handle configured to rotate with the drive gear shaft, and comprising a handle arm extending in a direction that axially intersects the drive gear shaft;
a vibration damper disposed between the drive gear shaft and the handle, and configured to dampen transmission of vibration of the drive gear;
a first transmitting member non-rotatably coupled to the handle arm and having an engagement portion; and
a second transmitting member configured to transmit rotation of the handle to the drive gear shaft,
the vibration damper elastically deformable, engaging an engagement portion of the first transmitting member, and being an elastic material with a lower rigidity than the first transmitting member,
the second transmitting member having a higher rigidity than the vibration damper and configured to engage the engagement portion of the first transmitting member after the vibration damper has been elastically deformed by a prescribed amount to transmit rotation of the handle to the drive gear shaft,
the engagement portion of the first transmitting member having at least one pawl receiving portion,
the vibration damper comprising an elastic pawl configured to engage the at least one pawl receiving portion,
the second transmitting member comprising a transmission pawl having a circumferential width that is narrower than a circumferential width of the elastic pawl of the vibration damper, and
the transmission pawl configured to engage the pawl receiving portion after the elastic pawl of the vibration damper has been elastically deformed by a prescribed amount.

US Pat. No. 10,244,743

HOVERING FISHING LURE ASSEMBLY

1. A rudderless device for floating on a body of water, pulling through the body of water by a fishing line, and having a fishing lure such that the lure appears to be flying above the surface of the body of water and moving independent of a movement of a rudderless floating body of the device consisting of:a) the rudderless floating body of the device having a front first end and a second back end, a top surface, which floats above the surface of the body of water, and a bottom surface, which floats at or below the surface of the body of water in use wherein the floating body comprises a longitudinal keel on the bottom surface of the body positioned to help it glide through the water, is weighted to prevent the body from tipping over due to the weight of the fishing lure, and the body is tapered from the front first end to the back rear end such that the second end is wider than the first end;
b) a fishing line eyelet with the fishing line attached, the eyelet attached to the floating body front first end and fishing line pulling the device through the water; and
c) a single wire which is positioned on the top surface of the device and is of a length wherein at least 7 inches and no more than about 18 inches sticks out of the body off the second back end, is held removably in place by a spring loaded eyelet, and has a lure only attached directly to one end of the wire, wherein the wire is of a stiffness that the wire holds the lure from just above the water to about 12 inches above the water and flexes in response to movement of the floating body such that the lure appears to be flying independent of the rudderless floating body without dipping the lure into the water while the device is being pulled by the fishing line; and
d) a pair of wings on opposite sides of the body located at a waterline when the device is in use on the body of water.

US Pat. No. 10,244,742

FISHING HOOK AND COVER

1. A fishing hook and cover comprising:a fishing hook rotatably engaged with respect to the cover in order to hide the fishing hook inside of the cover when not in use, and conversely extend from said cover when the fishing hook is in use;
wherein the fishing hook is attached via a hook hinge to the cover;
wherein the cover is further defined with a first cover member and a second cover member;
wherein the first cover member and the second cover member collectively form a cylindrically-shaped object;
wherein the cover is further defined with an interior;
 wherein the first cover member is further defined with a first interior surface;
wherein the second cover member is further defined with a second interior surface;
wherein the first interior surface includes a hook hinge thereon;
wherein the hook hinge attaches to the fishing hook;
wherein the cover is further defined with a first proximal end and a second distal end; wherein the first proximal end includes a first opening
wherein the second distal end includes a second opening;
wherein the first opening is formed from both the first cover member as well as the second cover member;
wherein the second opening is formed from both the first cover member as well as the second cover member;
wherein the hook hinge is located adjacent to the second distal end;
wherein the hook hinge attaches to a lateral hook member of the fishing hook;
wherein the fishing hook includes the lateral hook member in order to enable the fishing hook to rotate about a horizontal axis;
wherein the rotation of the fishing hook about the horizontal axis, and with respect to the hook hinge enables the fishing hook to rotate out of the cover as well as into the interior of the cover;
wherein the hook hinge enables the fishing hook to be concealed within the cover when the fishing hook is not in use;
wherein the first cover member and the second cover member are attached to one another via a cylinder hinge;
wherein the cylinder hinge is attached to a third edge of the first cover member as well as a fourth edge of the second cover member.

US Pat. No. 10,244,741

LURE

Hard and Soft Fishing, In...

9. A lure comprising:a head with a bore formed therein, wherein the bore extends from a first side of the head to a second side of the head;
a hook with a first end embedded in the head;
a sealed tube located within the bore and affixed to the head, the sealed tube made from a material that permits at least some light through the material; and
at least two noise making elements located within the sealed tube;
wherein when at least one of the at least two noise making elements contacts a first end of the sealed tube, the at least one of the at least two noise making elements make a noise;
wherein when at least one of the at least two noise making elements is positioned near the first end of the sealed tube, the at least one of the at least two noise making elements is observable through the first end; and
wherein when at least one of the at least two noise making elements is positioned near a second end of the sealed tube, the at least one of the at least two noise making elements is observable through the second end.

US Pat. No. 10,244,740

FLASHING FISH LURE

1. A flashing fish lure, comprising:a body having front, rear, top and bottom portions and two opposing side surfaces;
a bore formed in the body;
a glow stick insertable into the bore;
at least one water wheel on or in the body, the water wheel being rotatable about a side-to-side axis as the body is pulled through water, the side-to-side axis being transverse to a direction the body is pulled;
each water wheel including at least one light-transmissive aperture extending therethrough and structurally aligned with the bore at a point in rotation about the side-to-side axis, such that as the at least one water wheel rotates about the side-to-side axis, light is intermittently communicated from the glow stick, through the at least one aperture, and out one or both of the two opposing side surfaces to appear as an intermittently radiated light.

US Pat. No. 10,244,738

TEMPERATURE CONTROLLING AQUARIUM CLEANING DEVICE

Bernard Ruiz, Ridgewood,...

1. A temperature controlling aquarium cleaning device comprising:(1) a diverter body comprising:
(a) a diverter first end configured to removably couple to the water source,
(b) a diverter second end configured to allow a flow of dirty water through said water diverter member into a sink, and
(c) diverter connector configured to removably couple with a first end of a hose;
(2) a siphoning member comprising:
(a) a siphoning body with
(i) a first end configured to removably couple with a second end of the hose, and
(ii) a second end opposite the first end of the siphoning member,
wherein the siphoning member is configured to allow the flow of water therethrough; and
(3) an end cap is configured to be moveable between a filling position and a removing position at the water diverter second end, the filling position blocking flow of fresh water through the water diverter second end into the sink, thereby allowing the flow of fresh water into the aquarium, and the removing position allowing dirty water to flow from the aquarium through the water diverter second end into the sink;
wherein dirty water is removed from the aquarium by siphoning the dirty water through said siphoning second end, the dirty water then passes through the siphoning member, the hose, the diverter member, and exits said water diverter member second end into the sink, with the end cap in the removing position;
wherein fresh water is added to the aquarium by turning on the water source, as a result, the fresh water passes through said diverter body, the hose, and through said siphoning member into the aquarium, with the end cap in the filling position;
and
(4) a temperature gauge comprising:
(1) a sensor attached to a back surface of the gauge, the sensor configured to contact and sense a temperature of the fresh water entering said diverter body;
(2) a display member configured to display the measured temperature of the fresh water; and
(3) a power source configured to provide energy to said display member;
wherein said temperature gauge is fixedly attached to said diverter body.

US Pat. No. 10,244,737

MODULAR FORCE SENSOR SYSTEM, DEVICE, AND METHOD FOR BEHAVIORAL MEASUREMENT

University of Kansas, La...

1. A device for measuring the behavior of a test subject having two or more feet and having a first weight, the device comprising:a high resolution force module having a first surface, the first surface comprising:
an array of force sensors each individual force sensor capable of sensing an individual force, each force sensor of the array of force sensors positioned within a predetermined distance from any adjacent force sensor of the array of force sensors;
a rigid support module have a first surface, wherein the rigid support module comprises on or more vacuum ports configured to preload at least one of the array of force sensors;
a flexible stack forming the first surface of the high resolution force modules, the flexible stack containing the array of force sensors, and the flexible stack being secured to the first surface of the rigid support module; and
a control system in functional communication with the high resolution force module, the control system comprising a processor and physical memory, the control system containing instructions stored in the physical memory that when executed by the processor, cause the control system to perform the following acts:
receiving a first signal from a first sensor of the array of force sensors corresponding to a first foot of the two or more feet and receiving a second signal for a second sensor of the array of force sensors corresponding to a second foot at a predetermined rate;
determining a first amount of force applied by the first foot based on the first signal;
determining a second amount of force applied by the second foot based on the second signal; and
determining behavior of said test subject with respect to the first surface of the high resolution force module based on the first amount of force and the second amount of force.

US Pat. No. 10,244,736

SYSTEM AND METHOD FOR AUTOMATICALLY DETERMINING ANIMAL POSITION AND ANIMAL ACTIVITY

Lely Patent N.V., Maassl...

1. A method for automatically monitoring activity of an animal in a system for housing freely moving animals comprising a plurality of animal ID stations, the method comprising the steps ofa) recording a first visit of the animal at a first of the animal ID stations;
b) recording a subsequent second visit of the animal at a second of the animal ID stations;
c) determining a first distance between the first animal ID station at the first visit and the second animal ID station at the second visit, and
d) determining a distance covered by the animal on the basis of the first distance.

US Pat. No. 10,244,735

PET TREAT DELIVERY SYSTEMS

Starmark Pet Products, In...

1. An animal treat delivery system, comprising:an elongated body formed of an animal digestible material, said elongated body having an exterior surface and an interior surface defining an interior cavity extending along a longest dimension of the elongated body and terminating at an opening, wherein the interior surface includes a plurality of projections extending along the longest dimension of the elongated body and projecting from the interior surface into the interior cavity and terminating at free ends spaced apart from one another by at least at least an interior dimension; and
a plurality of discrete animal digestible treats disposed within the interior cavity of the elongated body, wherein:
the plurality of discrete animal digestible treats all have a first dimension less than the interior dimension;
one or more first treats among the plurality of discrete animal digestible treats are installed within the interior cavity in a first orientation such that the first treats easily slide along the interior cavity between the free ends of the plurality of projections; and
one or more second treats among of the plurality of discrete animal digestible treats have a second dimension fitting with interference fit in the interior dimension, and wherein the second treats are wedged between the free ends of the plurality of projections in a second orientation different from the first orientation, such that the one or more second treats temporarily retain the one or more first treats within the interior cavity and temporarily prevent the one or more first treats from sliding out the opening.

US Pat. No. 10,244,734

AUTOMATED PET FOOD DISPENSING MACHINE

1. A device for use in animal husbandry comprising:a housing, a mechanism, and a scheduler;
wherein the device for use in animal husbandry is designed for unattended operation;
wherein the device for use in animal husbandry is adapted for use with cans;
wherein the device for use in animal husbandry is further adapted for use with animals;
wherein the device for use in animal husbandry stores and opens canned food intended for consumption by animals;
wherein the device for use in animal husbandry further dispenses said canned food to make it available for consumption by an animal;
wherein the housing is a rigid casing that further comprises a container and a serpentine storage channel;
wherein the container is a hollow rigid structure;
wherein the container further comprises a bowl, a feed port, a can port, and a discharge port;
wherein the container is further defined with a first side, a second side, a third side, a fourth side, a fifth side, and a sixth side;
wherein the can port is an aperture formed in the second side;
wherein the can port is sized to receive the canned food;
wherein the discharge port is an aperture formed in the third side;
wherein the discharge port is sized to allow empty cans to be discharged from the device for use in animal husbandry
wherein the feed port is an aperture that is formed in the fourth side of the container;
wherein the bowl attaches to the container underneath the feed port;
wherein the serpentine storage channel is a gravity driven rack system;
wherein the serpentine storage channel serpentine storage channel stores the canned food;
wherein the serpentine storage channel is further defined with an intake end and a discharge end;
wherein the serpentine storage channel is inclined;
wherein the mechanism comprises a plurality of can openers, a first roller, a first roller motor, and a piston;
wherein the mechanism opens the canned food;
wherein the mechanism discharges the contents of the canned food through the feed port;
wherein the mechanism discharges the empty can through the discharge port.

US Pat. No. 10,244,733

ADAPTABLE FENCE EXTENSION ASSEMBLY

1. An adaptable fence extension assembly, the assembly comprising:an arc-shaped member, the arc-shaped member defined by a top end, a middle section, and a base end, the base end comprising a longitudinal slot, the longitudinal slot disposed along the length of the base end,
the top end and the middle section of the arc-shaped member having a continuous longitudinal curvature,
the arc-shaped member further defined by a concave side inside the curvature and coextensive with the top end and the middle section and a convex side outside the curvature and coextensive with the top end and the middle section, the concave side comprising at least one U-shaped cavity, the at least one U-shaped cavity defined by an inlet and a cavity terminus, the cavity terminus configured generally narrower than the inlet,
the arc-shaped member further defined by an interior channel, the interior channel longitudinally curved along its length,
the arc-shaped member configured to at least partially insulate electrical current;
at least one tine, the at least one tine disposed at the base end of the arc-shaped member, the at least one tine defined by at least one notch; and
a spine, the spine disposed along the length of the interior channel of the arc-shaped member, the spine configured to enhance the structural integrity of the arc-shaped member.

US Pat. No. 10,244,732

MILKING DEVICE

LELY PATENT N.V., Maassl...

1. A milking device, comprising:a platform which is rotatable in a direction of rotation and includes an edge and a plurality of milking stations, and milking means for milking a dairy animal;
a plurality of feeding troughs which are distributed along the edge outside of the platform, and fixed on a fixed world frame and configured to be within reach of dairy animals on the milking stations; wherein the plurality of feeding troughs are not rotatable with the platform when the platform rotates.

US Pat. No. 10,244,731

FOURTEEN-DEVICE-IN-ONE CRUMPLABLE-SEATBELTABLE-RAMPABLE-LEGGABLE-TOP-PANEL PET CRATE, HAVING CRUMPLABLE-SEATBELTABLE-RAMPABLE-LEGGABLE-TOP-PANEL SYSTEM, TOP PANEL-LOCKING-AND-RELEASING STOPPER-AND-HOOK SYSTEMS, SIDE PANEL-LOCKING-AND-RELEASING STOPPER-AND

1. A fourteen-device-in-one crumplable-seatbeltable-rampable-leggable-top-panel pet crate, having a thickness, comprising:a crumplable-seatbeltable-rampable-leggable top panel
for functioning as a hanger to hang said pet crate on a latch of an open tailgate of an SUV,
for functioning as an arm to attach said pet crate to a top edge of a closed tailgate of an SUV,
for functioning as a lid to hook said pet crate on a latch of an engine hood of an SUV,
for functioning as a convertor to clamp said pet crate to a top edge of an open door of an SUV,
for functioning as a car-seat fastener to fasten said pet crate to a car seat of an SUV,
for functioning as a spike to dig into slanted sandy beach,
for functioning as a spike to dig into slanted carpeted floor,
for functioning as a leg to support said pet crate,
for functioning as a ladder to allow a pet to walk up to or to walk down from a back of an SUV,
for functioning as a ramp to allow a pet to walk up to or to walk down from a back of an SUV,
for functioning as a ladder to allow a pet to walk up to or to walk down from a seat of an SUV
for reducing said thickness of said crumplable-seatbeltable-rampable-leggable-top-panel pet crate when said pet crate is folded to reduce space needed in shipping container to significantly reduce shipping cost of said pet crate,
for being an anchor when attached to seat or headrest or ceiling of automobile to provide immobilization of said pet crate while traveling,
for being a crumple zone when attached to seat or headrest of automobile to provide safety to pets in event of accident,
for being detached from said pet crate to convert said fully enclosed pet crate into open-top pet playpen,
for being quickly and easily removed to create one or multiple pet playpens or pet runs,
for being removed to create an open-top crate to make accessible for pets to create non-confining environment for pets or to create headroom for tall pet or to create way for pets to climb out of said pet crate or to jump out on adjacent playing or resting ramp or
balcony or patio to create multiple different configurations of pet runs or to allow pets to sit or stand or play or rest or sleep or climb upon,
for functioning as suspended top panel at different elevations,
for functioning as multi-pet divider or partition to accommodate two or more pets in side-by-side compartments,
for being secured to allow said crumplable-seatbeltable-rampable-leggable top panel to function as vertically-adjustable-height ceiling,
for functioning as multi-story floor to accommodate two or more pets in separate compartments stacked vertically, and
for functioning as wall or bridge between a plurality of said pet crates to provide a dry above-ground walking surface for pets;
a bottom panel for functioning as a floor;
a left panel having first opening therein for functioning as a wall;
a right panel for functioning as a wall;
a front panel having second opening therein for functioning as a wall;
a rear panel for functioning as a wall;
a urine-waste-catching tray disposed on said bottom panel
for catching urine and waste and
for storing said crumplable-seatbeltable-rampable-leggable top panel therein to significantly reduce said thickness when said pet crate is folded for storage and transportation;
a removable multi-elevation mezzanine
for creating multiple pet-containing compartments to accommodate two or more pets,
for creating multiple sized pet-containing compartments to accommodate pet growth from puppy to adult stage,
for creating multiple sized pet-containing compartments to accommodate large and small pets simultaneously,
for separating multiple pets to allow multiple pets to sleep or rest or play simultaneously therein,
for providing vertical separating means within said pet crate to confine multiple pets in independent compartments side by side to function as partition or as divide,
for providing horizontal separating means within said pet crate to confine multiple pets in independent compartments above or below one another,
for providing means to create horizontal platform within said pet crate to function as pet mezzanine or pet shelf or pet step or pet floor or pet ceiling,
for providing means to attach to the interior or exterior of said pet crate to function as a pet bridge or pet step or gate or support to said crumplable-seatbeltable-rampable-leggable top panel, and
for providing means to connect between a plurality of said pet crates as exterior panel to function as wall or floor;
a plurality of panel-coupling clips
each having a C shape for hingeably coupling said bottom, said left, said right, said front, and said rear panels together;
a panel-folding clamp
foldably hinged to said bottom panel for releasably clamping said top, said bottom, said left, said right, said front, and said rear panels together when said pet crate is folded;
a tray-locking clamp
foldably hinged to said bottom panel for releasably locking said urine-waste-catching tray inside said pet crate;
a plurality of top arms
each having a two-parallel-I shape and welded to said crumplable-seatbeltable-rampable-leggable top panel;
a plurality of top stoppers
each having a two-parallel-C shape and molded to corresponding ends of said top arms for resisting said top, said left, said right, said front, and said rear panels to warp, to bend, and to wobble and for resisting said top, said left, said right, said front, and said rear panels to fold;
a plurality of top hooks
each having a two-parallel-C shape and molded to corresponding ends of said top stoppers for resisting said top, said left, said right, said front, and said rear panels to warp, to bend, and to wobble and for resisting said top, said left, said right, said front, and said rear panels to fold;
a plurality of side arms
each having a two-parallel-I shape and welded to said left and said right panels;
a plurality of side hooks
each having a two-parallel-C shape and molded to corresponding ends of said side arms for resisting said top, said left, said right, said front, and said rear panels to warp, to bend, and to wobble and for resisting said top, said left, said right, said front, and said rear panels to fold;
a plurality of side stoppers
each having a two-parallel-C shape and molded to corresponding ends of said side hooks for resisting said top, said left, said right, said front, and said rear panels to warp, to bend, and to wobble and for resisting said top, said left, said right, said front, and said rear panels to fold;
a plurality of removable crumple-zone multi-elevation locking clamps
each having a ring shape for being grasped,
for attaching said crumplable-seatbeltable-rampable-leggable top panel to seat or headrest of automobile to be crumple zone to absorb collision force and provide safety to pets in event of accident, and
for attaching to U-shaped locking hook of tailgate of automobile to be an anchor to allow said crumplable-seatbeltable-rampable-leggable top panel to function as a ramp for pets to enter or exit rear compartment of automobile;
a plurality of removable crumple-zone multi-elevation locking double clips
each having a two-tandem-C shape and respectively molded to a corresponding end of said removable crumple-zone multi-elevation locking clamps for attaching and removing said crumplable-seatbeltable-rampable-leggable top panel to and from said removable multi-elevation mezzanine, said bottom, said left, said right, said front, and said rear panels at a plurality of angles and elevations,
for attaching and removing said removable multi-elevation mezzanine to and from said crumplable-seatbeltable-rampable-leggable top panel, said bottom, said left, said right, said front, and said rear panels at a plurality of angles and elevations,
for attaching and removing said pet crate to and from additional pet crate,
for attaching said crumplable-seatbeltable-rampable-leggable top panel to be anchor when attached to seat, headrest or ceiling of automobile to provide immobilization of said pet crate while traveling, and
for attaching said crumplable-seatbeltable-rampable-leggable top panel to seat or headrest of automobile to function as crumple zone to absorb collision force and provide safety to pets in event of accident;
a plurality of removable crumple-zone multi-elevation accessory-hanging ring hooks
each having a C shape and respectively molded to a corresponding end of said removable crumple-zone multi-elevation locking clamps for attaching said crumplable-seatbeltable-rampable-leggable top panel to seat or headrest of automobile to function as crumple zone to absorb collision force and provide safety to pets in event of accident,
for hooking and holding a towel thereon,
for hooking and holding a napkin thereon,
for hooking and holding medicine thereon, and
for hooking and holding a toy thereon;
first and second doors respectively hinged on said left and said front panels for respectively closing and opening said first and said second openings;
first and second push-rod hinges respectively welded to said first and said second doors;
first and second push-rods respectively and rotatably attached to said first and said second push-rod hinges;
first and second push-rod levers respectively welded to said first and said second push-rods; and
first and second push-rod-locking rings respectively welded to said left and said front panels for respectively and releasably locking said first and said second push-rods therein.

US Pat. No. 10,244,730

DIGESTATE COMPOSITION COMPRISING LIGNOCELLULOSIC FIBROUS MATERIALS AND METHOD

CCD Holdings LLC, Hollan...

1. Digestate composition, comprising:at least one solvent;
a lignocellulosic fiber processed by ruminant digestion and anaerobic digestion; and
wherein a density fiber of the digestate composition ranges from between approximately 0.400 grams per cubic centimeter to approximately 1.40 grams per cubic centimeter.

US Pat. No. 10,244,729

MILK SAMPLING DEVICE

DELAVAL HOLDING AB, Tumb...

1. A milk sampling device comprising;a housing (3) forming an inner space, the housing having an inner surface (11a, 12a) and an inlet opening (4a) to the inner space;
a deflector member (13) provided with an upper surface (13a) with a periphery edge portion (13b), where a flow passage (18) is formed between the periphery edge portion (13b) of the deflector member (13) and the inner surface (11a, 12a) of the housing (3), the deflector member (13) being mounted in the inner space of the housing (3) in a position below the inlet opening (4a), the deflector member (13) being configured to receive and temporarily accumulate milk entering the housing (3) through the inlet opening (4a); and
a milk sampling passage (5) with at least one opening (5a) which constitutes a part of the flow passage (18),
wherein a plurality of upwardly extending members (13c) are arranged on the upper surface (13a) of the deflector member (13) at a distance from each other in a vicinity of the periphery edge portion (13b) of the deflector member (13) such that flow channels (13d) are formed between adjacent ones of the upwardly extending members (13c) along the periphery edge portion (13b) of the deflector member (13), and
wherein the deflector member (13) is configured to temporarily accumulate milk entering the housing through the inlet opening (4a) and distribute the milk through the flow channels into the flow passage (18), and from the flow passage (18) into the at least one opening (5a) of the milk sampling passage (5).

US Pat. No. 10,244,692

METHOD OF IMPROVED PLANT BREEDING

BASF Plan Science GmbH, ...

1. A plant breeding system for high throughput analysis of genetic traits in plants, comprising:(a) a first transporter system comprising a plurality of co-extensive storage transporters and a transfer conveyor adjacent to an end portion of the co-extensive storage transporters,
wherein each storage transporter provides support for a row of several containers charged with growing medium of uniform characteristics, each container comprising one or more plants and each plant or container being associated with a machine-readable identification that distinguishes the plant or container from other plants or containers,
wherein each storage transporter comprises a belt supporting the row of several containers, the belt being pulled back or forth by a motor allowing transport of the containers to or from the transfer conveyor;
wherein the transfer conveyor cooperates with the storage transporters to allow the containers to be transported back and/or forth from one storage transporter to another storage transporter;
(b) a continuous system for digital imaging of a plant comprising a second transporter system for moving one or more plants at one or more intervals during its growing cycle through the system for digital imaging while being turned and imaged in a controlled manner, a belt mechanism for turning the containers in a controlled manner, and one or more digital imaging devices,
wherein the belt mechanism of the system for digital imaging comprises time-belts,
wherein the time-belts and/or the containers are coated with a friction material having a coefficient of friction of about 0.6 or more,
wherein the time-belts are positioned in order to grip the sides of the containers; and
(c) a computer apparatus for analyzing digital images and/or information of one or more characteristics of the one or more plants taken with the one or more digital imaging devices.

US Pat. No. 10,244,690

STRUCTURE OF PLANTING TRAY

1. An improved structure of a planting tray, including:a planting tray set on a channel component; wherein
multiple planting holes, each having one side and another side, and gradually narrowing from the one side to the other side, are evenly distributed on the planting tray,
a foam filling member is placed in each of the multiple planting holes,
multiple convex positioning protrusions are formed on an inner side of each of the multiple planting holes for holding the foam filling member, so that planted plants passing through each of the multiple planting holes are supported by each foam filling member,
for each of the multiple planting holes, an outer perimeter of an opening at the one side has two first diametrically opposed side concave portions and two second diametrically opposed side concave portions,
wherein the two first diametrically opposed side concave portions each have a greater degree of curvature than the two second diametrically opposed side concave portions; and
wherein each of the multiple convex positioning protrusions separate each of the side concave portions from an adjacent of the side concave portions, and each of the multiple convex positioning protrusions extend inwardly relative to the side concave portions and terminate at a position above a bottom of each of the multiple planting holes.

US Pat. No. 10,244,689

SOILLESS PLANT CULTIVATING CONTAINER

E-SMARTS GLOBAL LICENSING...

1. A soilless plant cultivating container comprising:an elongate body of wave shaped form and having a flow channel defined therethrough;
a receptacle defined in a sidewall of the body in fluid communication with the flow channel to receive and support a plant therein, and
the elongate body further including an air passage arranged separate from the flow channel and extending longitudinally therealong, the air passage being in fluid communication with the receptacle for introducing temperature and oxygen regulated air to the receptacle.

US Pat. No. 10,244,688

METHOD FOR INSTALLING IRRIGATION DRIP LINE COUPLERS

1. A method of installing a drip line to a main drip line comprising the steps of:puncturing the main drip line with a needle member of an integral tool creating a hole;
attaching the drip line to a drip line coupler of the type having a first male end for insertion into the main drip line and having a second male end for insertion into an end of the drip line, and a shoulder member intermediate of the first end and the second end, the shoulder member having an external diameter;
inserting the second male end of the drip line coupler into the end of the drip line; and
pushing the first male end of the drip line coupler into the hole with a head member of the integral tool, the head member comprising a first leg member and a second leg member, wherein a slot is defined between the first leg member and the second leg member, wherein the slot has a width smaller than the external diameter.

US Pat. No. 10,244,687

LED GROW LIGHT SYSTEM

Spectrum King LLC, Canog...

1. An LED grow light system, comprising:an LED coupled to a circuit board;
a phosphor layer generally positioned at least partially over the LED coupled to the circuit board;
a filter positioned in light receiving relation relative to the LED coupled to the circuit board and in light reflective relation relative to the phosphor layer, the filter comprising a material at least partially reflective of at least a first light output wavelength emitted from the LED for redirection back into the phosphor layer where the reflected first light output wavelength converts to a second light output wavelength for recycled emission out from the LED grow light system as a composite light output component comprising a mixture of the first light output wavelength and the second light output wavelength; and
an adhesive selectively securing the filter to the phosphor layer, wherein the filter comprises a filter substrate having a filter coating on an external surface area of the LED grow light system.

US Pat. No. 10,244,686

LANDSCAPING TOOL FOR EDGING AND GRADING

1. A landscaping tool comprising:a substantially vertical blade, the blade comprising a first end, a second end, a top edge, a bottom edge, a front side and a back side;
a substantially vertical cutting edge disposed on the first end of the blade;
a grader disposed at the second end of the blade, the grader arching away from the blade in the direction of the front side of the blade;
a substantially horizontal cultivator disposed along the bottom edge of the blade at substantially a right angle to the blade, the cultivator comprising a leading edge and a boundary edge, the cultivator being angled in the direction of grader such that the angle between the substantially vertical cutting edge and the leading edge of the cultivator is greater than ninety degrees;
a juncture formed at the union of the cutting edge of the blade and the leading edge of the cultivator.

US Pat. No. 10,244,685

STRAW CHOPPERS FOR AN ARTICULATED HARVESTING COMBINE

Tribine Industries LLC, ...

1. Straw chopper assemblies for a harvesting combine having a rotor and cage threshing assembly, which comprises:(a) straw chopper assemblies located on each side of the rotor discharge, the straw chopper assemblies accept straw material exiting the rotor, each straw chopper assembly comprising:
(i) a curvilinear cage having an interior opening that accepts the rotor discharged straw material, and an opening that distributes chopped straw material to outside of the harvesting combine;
(ii) a rotating assembly of knives housed within the curvilinear cage having slots between adjacent rotating knives;
(iii) a shaft captured stationary assembly of knives movable for the rotating knives to pass fully, partially, or not at all between adjacent pairs of stationary knives, the stationary knife assembly comprising partial circular shaped knives such that the partial circular shaped knives fill the rotating knife assembly slots that the stationary knives are movable within to contain the rotor discharged straw material within the straw chopper assembly;
(b) outlets in chopped straw material communication with the curvilinear cage opening through which the chopped straw material is discharged onto the ground adjacent to a side of the harvesting combine; and
(c) hoods located over each of the outlets that direct the discharged chopped straw material onto the ground.

US Pat. No. 10,244,684

RECTANGULAR BALER WITH IMPROVED STUFFER MECHANISM

CNH Industrial America LL...

1. A rectangular baler comprising:a baling chamber;
a plunger reciprocally mounted in the baling chamber for compressing crop material;
an intake duct for accumulating crop material before transfer into the baling chamber;
a pick-up mechanism for picking up crop material and introducing the crop material into the intake duct; and
a stuffer mechanism configured to selectively execute a packer stroke to advance crop material partially along the intake duct and a stuffer stroke to transfer the crop material accumulated in the intake duct into the baling chamber, the stuffer mechanism comprising two stuffer assemblies at each side of the baler and a tine bar extending between the two stuffer assemblies, and at least one of the two stuffer assemblies comprising:
a first stuffer arm connected at a first pivot point to a first crank arm of a first drive mechanism;
a second stuffer arm connected at a second pivot point to a second crank arm or disc of a second drive mechanism; and
a coupling plate pivotally mounted around a stationary pivot point, the coupling plate coupling the first stuffer arm with the second stuffer arm, wherein the coupling plate is coupled to the first stuffer arm through a connection configured to allow a predetermined limited movement of the first stuffer arm with respect to the coupling plate, and wherein the coupling plate comprises a top corner and a bottom corner,
wherein the second stuffer arm is pivotally connected to the coupling plate at a pivot point located between the top and bottom corners of the coupling plate, and
wherein the tine bar is connected to the first stuffer arm.

US Pat. No. 10,244,683

DRIVE SYSTEM FOR COMBINE HARVESTER PROCESSOR AND METHOD OF PROVIDING SUCH

AGCO Corporation, Duluth...

1. A combine harvester comprising:an axial flow crop processor with a rotor mounted for rotation inside a rotor housing arranged substantially longitudinally with respect to the harvester;
a feed beater mounted for rotation on a substantially transverse axis and serving to tangentially impel crop material into the crop processor;
a multi-speed beater drive system comprising:
a beater shaft upon which the beater is mounted via bearings to permit relative rotational movement;
a secondary shaft arranged parallel to the beater shaft;
a first selectable drive path between the beater shaft and the beater; and,
a second, alternate, selectable drive path between the secondary shaft and the beater; and
a grain cleaning shoe driven via a driveline which includes the secondary shaft;
wherein both the beater shaft and the secondary shaft are driven simultaneously during operation.

US Pat. No. 10,244,682

CONVEYOR BELT AND AGRICULTURAL HARVESTER WITH A CONVEYOR BELT

Maschinenfabrik Krone Bet...

1. A conveyor belt comprising:conveyor belt segments comprising an elastomeric material layer and a reinforcement layer of steel ropes disposed in the elastomeric material layer and arranged so as to be oriented in a longitudinal direction of the conveyor belt segments, wherein the conveyor belt segments each have a first segment end provided with a first transverse lock bar and a second segment end provided with a second transverse lock bar, wherein ends of the steel ropes are locked frictionally or with form fit in the first and second transverse lock bars, respectively;
detachable closure members coupling the first and second transverse lock bars of adjacently positioned ones of the conveyor belt segments to each other in a rigid correlation relative to each other;
wherein the conveyor belt segments are arranged to form a first belt and a second belt extending parallel to each other;
rod elements oriented at least approximately transversely to a running direction of the conveyor belt, wherein the rod elements each comprise a first end disposed at the first belt and a second end disposed at the second belt, respectively;
wherein the detachable closure members comprise fastening means fastening the first end to the first belt or the second end to the second belt, respectively.

US Pat. No. 10,244,681

DUAL CAM CONTROLLED REEL TINES

AGCO Corporation, Duluth...

1. A crop-harvesting header for use with an agricultural harvesting machine, the header having a reel positioned in the forward part thereof for manipulating a crop to be harvested, the reel comprising:a center structural member extending along the length of the reel, the center structural member being rotatable about an axis of the reel;
a plurality of rotatably mounted tine-supporting members at angularly spaced positions around the axis of the reel, each tine supporting member having a tine axis, wherein each of the plurality of tine-supporting members has a plurality of tines that project outwardly for engaging the crop; and
a dual-cam linkage system configured to change an angular orientation of each of the plurality of tine-supporting members and the tines mounted thereon, wherein for each of the plurality of tine-supporting members the dual-cam linkage system comprises:
a first cam track around the rotational axis of the reel that has a rotational center that is offset from the rotational axis of the reel such that a distance between the first cam track and the rotational axis varies according to a position on the first cam track around the rotational axis;
a second cam track having a fixed spatial relationship with the tine axis of the tine-supporting member;
a pivoting linkage comprising:
a crank, the crank having a first end attached to the tine-supporting member;
an arm, the arm having an outer end attached to a second end of the crank;
a first cam follower attached at an inner end of the arm, the first cam follower engaging the first cam track; and
a second cam follower attached to the arm at a position between the first cam follower and the crank, the second cam follower engaging the second cam track such that the fixed spatial relationship of the second cam track with the tine axis of the respective tine-supporting member guides movement of the arm as a distance of the first cam follower from the rotational axis of the reel is changed by the first cam such that rotational movement of the reel causes the dual-cam linkage system to change an angular orientation of each of the plurality of tine-supporting members and the tines mounted thereon.

US Pat. No. 10,244,680

AUTOMATIC CALIBRATION SYSTEM FOR HEADER HEIGHT CONTROLLER WITH OPERATOR FEEDBACK

Headsight, Inc., Bremen,...

1. A method of calibrating a header height controller, the header height controller comprising processing circuitry capable of receiving output signals from a plurality of height sensors mounted to a header, the output signals variable in magnitude with respect to changes in height of the header relative to a surface, the header height controller responsive to the output signals from the plurality of height sensors, the method comprising the steps of:moving the header through a range of motion relative to a surface;
as the header moves through the range of motion, receiving and storing at predetermined sampling intervals the output signal magnitudes for each of the plurality of height sensors;
defining a Set Point C Magnitude (“SPCM”) for each of the plurality of height sensors, wherein the SPCM is the magnitude of the output signal when the header is at a lowest point of the range of motion;
defining a Set Point A Magnitude (“SPAM”) for each of the plurality of height sensors, wherein the SPAM is the magnitude of the output signal at a predetermined elevation above the lowest point of the range of motion;
identifying anomalies between the output signal magnitudes at predefined points of the sampling intervals of each of the plurality of height sensors.

US Pat. No. 10,244,679

FLOW RATE CONTROL FOR A COMBINE HARVESTER UNLOADING SYSTEM

AGCO Corporation, Duluth...

1. A grain unloading system for a combine harvester comprising:a grain bin comprising a frame, the frame comprising a floor with a trough disposed therein;
an unloading auger disposed at least partially within the trough;
an auger cover that at least partially covers the auger, the auger cover comprising a hat for a top portion of the auger cover and a pair of gates movable between the hat and locations on the floor that are proximal to the trough;
a gate adjustment structure coupled to the pair of gates to move the pair of gates relative to the auger; and
a control system coupled to the gate adjustment structure and configured to control the gate adjustment structure;wherein the gates are each provided with a plurality of external projections comprising outwardly-projecting fingers that extend in a direction away from the auger to agitate and dislodge blocked crop.

US Pat. No. 10,244,678

BLADE GUARD FOR A ROBOT LAWNMOWER

iRobot Corporation, Bedf...

1. An autonomous robot lawnmower comprising:a drive supporting the robot lawnmower above a lawn and configured to maneuver the robot lawnmower about the lawn;
a motorized lawn cutting assembly comprising one or more blades;
a first blade guard movably mounted to a first lateral side of the robot lawnmower, positioned at least partially below a horizontal plane in which the one or more blades of the cutting assembly are located, and extending from the first lateral side of the robot lawnmower toward the lawn, the first blade guard being movable toward the one or more blades of the cutting assembly, wherein the first blade guard has a substantially planar front facing surface forming a non-perpendicular angle with a substantially planar outward facing surface of the first blade guard such that a rearward directed force on the front facing surface moves the first blade guard towards the one or more blades of the cutting assembly; and
a second blade guard movably mounted to a second lateral side of the robot lawnmower and extending from the second lateral side toward the lawn, the second blade guard being movable toward the one or more blades of the cutting assembly, wherein the second blade guard has a front facing surface forming a non-perpendicular angle with an outward facing surface of the second blade guard such that a rearward directed force on the front facing surface of the second blade guard moves the second blade guard towards the one or more blades of the cutting assembly.

US Pat. No. 10,244,677

HAND TOOLS HAVING A PROTECTIVE HAND GUARD

1. A tool comprising:a first rake body having a proximal end and an opposite distal end, the first rake body comprising:
a handle portion extending from the proximal end toward the distal end of the first rake body, wherein the handle portion has a planar shape defining a top surface, an opposite bottom surface, a first side, and an opposite second side of the handle portion, and wherein the handle portion comprises: a finger opening extending from the top surface to the bottom surface of the handle portion and configured to receive a user's fingers therethrough;
a first plurality of tabs extending laterally outward along the first side of the handle portion; and
a second plurality of tabs extending laterally outward along the second side of the handle portion; and
a first rake portion extending from the distal end of the first rake body to the handle portion, wherein the first rake portion is integrally formed with the handle portion, wherein a majority of the first rake portion has a planar shape and is coplanar with the handle portion, and wherein the first rake portion comprises:
a plurality of tines; and
a plurality of cross-members extending between adjacent tines and oriented transverse to a longitudinal extent of the tines; and
a hand guard attached to the first rake body and positioned over a top surface of the handle portion, wherein the hand guard comprises an open proximal end, an opposite, closed distal end, and a plurality of walls defining an interior space configured to receive the user's hand therein, and wherein the plurality of walls of the hand guard comprises:
a front wall positioned along the distal end of the hand guard;
a top wall extending from the proximal end of the hand guard to the front wall;
a first sidewall extending from the proximal end of the hand guard to the front wall, wherein the first sidewall extends below the bottom surface of the handle portion, and wherein the first sidewall comprises a first plurality of mounting holes engaging the first plurality of tabs; and
a second sidewall extending from the proximal end of the hand guard to the front wall, wherein the second sidewall extends below the bottom surface of the handle portion, and wherein the second sidewall comprises a second plurality of mounting holes engaging the second plurality of tabs.

US Pat. No. 10,244,676

SELF-PROPELLED AGRICULTURAL PRODUCT APPLICATION IMPLEMENT

CNH Industrial America LL...

1. A self-propelled agricultural product application implement for delivering liquid or dry product to an agricultural field, the implement comprising:a chassis defining front and back ends and supporting a cab, an engine, and an applicator arrangement for delivering a liquid or dry product to an agricultural field;
a product container for storing the liquid or dry product and arranged at least partially between the front and back ends of the chassis, the product container including multiple container sections storing respective portions of the liquid or dry product and separated from each other by at least one divider wall extending transversely with respect to the implement such that the multiple container sections are longitudinally aligned with each other along a longitudinal axis of the implement;
an outlet system including multiple variable outlet arrangements respectively arranged between the multiple container sections and the applicator arrangement, the outlet system configured to selectively permit product to flow from one of the multiple container sections, past a respective one of the multiple variable outlet arrangements, and out of the applicator arrangement;
a control system operatively connected to the product container and to the outlet system, the control system configured to:
monitor weights of each of the multiple container sections;
determine an actual front-to-back weight distribution of the implement;
determine an emptying strategy for emptying the multiple containers at different times such that the actual front-to-back weight distribution of the implement approximates a target front-to-back weight distribution of the implement that provides a desired traction characteristic for the implement; and
command the outlet system to selectively permit product to flow from a selected one of the multiple container sections in accordance with the emptying strategy.

US Pat. No. 10,244,675

FIELD ROBOT

Veritas FC LLC, Spokane,...

1. An autonomous mobile field robot configured to be used in a field having sub-regions, the field robot comprising:one or more environment sensors;
a global positioning system (GPS) receiver;
one or more collapsible set of wings having a first position to let light through to at least one of the sub-regions and a second position to block the light and to provide shade to the at least one sub-region;
one or more chemical storage units for adjusting one or more parameters of a soil of the sub-regions;
a processor;
a network interface coupled to the processor configured to enable communications via a radio access network;
a storage device for content and programming;
a program stored in the storage device, wherein execution of the program by the processor configures the field robot to perform acts comprising:
performing soil mechanics with the one or more environment sensors at each sub-region and storing the soil mechanics in the storage device;
determining a soil temperature of each sub-region and storing the soil temperature in the storage device;
sending the soil mechanics and the soil temperature for each sub-region to a monitoring server via the radio access network for storage and analysis;
adjusting one or more parameters of the soil of a sub-region based on the soil mechanics of the corresponding sub-region with the chemicals from the one or more chemical storage units;
determining whether to provide shade to the sub-region based on at least one of the soil mechanics and the soil temperature corresponding to the sub-region; and
setting the one or more collapsible set of wings to the second position to provide the shade to the sub-region in response to determining to provide the shade.

US Pat. No. 10,244,674

MULTIPLE AGRICULTURAL PRODUCT APPLICATION METHOD AND SYSTEMS UTILIZING A DRUM METERING SYSTEM

Kinze Manufacturing, Inc....

1. A row unit for use with an agricultural planting implement and capable of planting a variety of seed types in a single field, the row unit comprising:a seed meter comprising:
a. a rotatable seed drum including a plurality of seed paths comprising a plurality of seed cells spaced about the seed drum, each of said seed paths corresponding to one of the variety of seed types to be planted and each of the seed paths adjacent to one another on a single drum, said rotatable seed drum further comprising a plurality of seed pools corresponding to the number of seed paths; and
b. a discharge mechanism operatively connected to the plurality of seed paths, wherein operation of the discharge mechanism with a seed path will discharge a seed variety associated with said path from the seed cells; and
a seed to ground system for directing the selected seed variety associated with the selected seed path to the ground for planting.

US Pat. No. 10,244,673

AGRICULTURAL AIR CART BLOWER FAN ARRANGEMENT

CNH Industrial Canada, Lt...

1. An agricultural implement, comprising:a chassis;
a plurality of wheels coupled to the chassis; and
a pneumatic distribution system coupled to the chassis, the pneumatic distribution system including:
at least one tank capable of storing and releasing agricultural product;
a metering arrangement including conduit capable of transporting the agricultural product; and
a blower fan arrangement configured to transport the agricultural product, the blower fan arrangement including a first blower fan and a second blower fan, each blower fan having an air inlet and an air outlet, and a transition section fluidly coupling the air outlet of the first blower fan with the air inlet of the second blower fan,
wherein the transition section includes an inlet end and an outlet end, and is generally pyramid-shaped with a truncated inlet end smaller than the outlet end, and
wherein the transition section has a generally square-shaped cross-section of the outlet end.

US Pat. No. 10,244,672

METERING SYSTEM FOR AN AGRICULTURAL MACHINE

Horsch Maschinen GmbH, S...

1. A metering system for a row unit of an agricultural machine for an individual dispensing of grains, comprisingat least two metering devices, whereby the at least two metering devices include at least one chamber for carrying a quantity of the grains that are to be dispensed,
at least two metering elements that establish a border to the at least one chamber, whereby the at least two metering elements are rotatably mounted within the housing of the at least two metering devices and each of the metering elements includes openings, which are arranged along a curved path at regular intervals for picking up grains, and
at least one grain dispensing area, which is defined by the at least one chamber and by the at least two metering elements, wherein the at least one grain dispensing area is adjacent a seed inlet element for a seed metering pipe through which the separated grains are dispensed into a seed furrow in the soil, and
whereby a pressure application device, in communication with the at least one chamber or to a pipe of the air supply of the at least one chamber or in communication with both the at least one chamber and to the pipe of the air supply of the last least one chamber, operably produces a stream of air in the grain dispensing area having a pressure that is sufficiently greater than ambient pressure such that the grains released from a selected metering element are accelerated by the stream of air into the seed metering pipe.

US Pat. No. 10,244,671

TURF TREATMENT

RICHARD CAMPEY LIMITED, ...

1. Equipment adapted for the treatment of turf, including turf reinforced with artificial grass fibres, the turf comprising grass planted in a matrix of sand or soil, and thatch, by removing the grass, the thatch, and the matrix of sand or soil to a depth d below a surface level of the matrix, the equipment comprising a horizontal rotor having blades having peripherally distributed teeth at least of length d, and drive means to traverse and rotate the horizontal rotor over the turf, characterised by blade height control means adapted to deploy the peripherally distributed teeth to a depth d below the surface level of the matrix to remove the grass, the thatch, and the matrix of sand or soil.
US Pat. No. 10,246,696

PECTINASES WITH IMPROVED THERMOSTABILITY

Metgen OY, Kaarina (FI)

1. A polypeptide with pectate lyase activity, the polypeptide comprising:an amino acid sequence that is at least 70% identical to the amino acid according to SEQ ID NO: 1, and a small, polar, non-charged amino acid residue at an amino acid position corresponding to position 235 in SEQ ID NO: 1, and wherein the polypeptide has an improved thermostability compared to an identical polypeptide not having said substitution.
US Pat. No. 10,246,697

COLISTIN SYNTHETASES AND CORRESPONDING GENE CLUSTER

Centre National de la Rec...


the bold amino acids D216, G217, F220, F259, L283, G285, V309, V317, Y318, and K505 being conserved and forming a binding pocket specific for a leucine, isoleucine or valine residue.
US Pat. No. 10,247,722

USE OF COMPOUNDS INHIBITING APELIN / APJ / GP130 SIGNALING FOR TREATING CANCER

Centre National de la Rec...

1. A method for identifying compounds capable of inhibiting Cancer Stem Cells properties, wherein said properties are potency, self-renewal, and survival, said method comprising the steps:a) contacting cells that have been transfected with exogenous nucleotide vectors expressing the co-receptors APJ and GP130 or are Cancer Stem Cells expressing the co-receptors APJ and GP130 with the Apelin polypeptide and a candidate compound,
b) detecting the activation level of an Apelin-dependent signaling pathway in the cells contacted in step a), and
c) detecting the activation level of an Apelin-dependent signaling pathway in cells that have been transfected with exogenous nucleotide vectors expressing the co-receptors APJ and GP130 or are Cancer Stem Cells expressing the co-receptors APJ and GP130 contacted only with the Apelin polypeptide;
wherein a candidate compound that impairs the activation level of an Apelin-dependent signaling pathway in cells from step a) as compared with cells from step c) is capable of inhibiting the potency and/or the self-renewal and/or the survival of Cancer Stem Cells.
US Pat. No. 10,246,700

METHODS AND APPARATUSES FOR GENE PURIFICATION AND IMAGING

NanoString Technologies, ...

1. A cartridge configured for purifying a hybridized target molecule sample and imaging a hybridized target molecule, comprising:a sample input area configured to hold a target molecule sample, the sample comprising:
a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with a first probe and a second probe,
a plurality of non-hybridized first probes, and
a plurality of non-hybridized second probes;
a first binding chamber configured to receive or contain a first affinity matrix and to receive the sample, wherein:
the first affinity matrix is functionalized with first molecules configured to bind with the non-hybridized first probes and hybridized complexes of the sample during a first period of time;
the first binding chamber is additionally configured to receive a first buffer to remove non-hybridized second probes from the sample after the non-hybridized first probes and hybridized complexes of the sample bind with the first affinity matrix;
a first elution channel attached to the first binding chamber and a means for heating, and which is configured to receive the first affinity matrix after the first period of time and configured for heating the first affinity matrix to elute a first eluted sample comprising the plurality of hybridized complexes and plurality of non-hybridized first probes;
a second binding chamber configured to receive or contain a second affinity matrix and to receive the first eluted sample, wherein:
the second affinity matrix is functionalized with second molecules configured to bind with the hybridized complexes during a second period of time;
the second binding chamber is additionally configured to receive a second buffer to remove at least non-hybridized first probes;
a second elution channel attached to the second binding chamber and a means for heating, and which is configured to receive the second affinity matrix after the second period of time and configured for heating the second affinity matrix to elute a second eluted sample comprising the plurality of hybridized complexes; and
a binding area having an active binding surface configured to receive the second eluted sample and bind with the hybridized complexes.
US Pat. No. 10,247,725

CAPTURE, IDENTIFICATION AND USE OF A NEW BIOMARKER OF SOLID TUMORS IN BODY FLUIDS

CREATV MICROTECH INC., P...

1. A method of screening a subject for cancer, comprising detecting circulating Cancer Associated Macrophage-Like cells (CAMLs) in a biological sample from a subject previously determined to be high risk for cancer, wherein said detecting comprises:(a) isolating intact cells of between 20 and 300 micron in size from a biological sample obtained from a subject using a microfilter having pores of about 7-8 micros, wherein the biological sample is peripheral blood, and
(b) selecting multi-nucleated cells isolated in (a) expressing one or more of the following markers: endothelial cell markers CD146, CD202b, and CD31, and monocyte cell markers CD11c and CD14, wherein antibodies are used to select cells expressing the one or more markers, thereby detecting CAMLs in a biological sample from a subject,
wherein when CAMLs are detected in the biological sample, the subject is determined to have cancer.
US Pat. No. 10,249,774

CONDUCTIVE PASTE FOR FORMING SOLAR CELL ELECTRODE

SHOEI CHEMICAL INC., Shi...

1. A conductive paste for forming a solar cell electrode, said conductive paste comprising a tellurium-based glass frit containing, in terms of oxide, 40-60 mol % of tellurium, 20-30 mol % of tungsten, 7-20 mol % of zinc, 5-10 mol % of boron and 1-5 mol % of zirconium, a conductive powder having silver as a main component and a specific surface area of at least 0.4 m2/g and an organic vehicle, wherein 0.1-10 mass parts of the tellurium-based glass frit is contained in the conductive paste with respect to 100 mass parts of the conductive powder.
US Pat. No. 10,246,705

LINKING SEQUENCE READS USING PAIRED CODE TAGS

Ilumina, Inc., San Diego...

1. An artificial transposon, comprising:a first transposase recognition site,
a second transposase recognition site,
a barcode disposed therebetween, wherein the barcode comprises a double-stranded nucleic acid sequence comprising
a first strand barcode and
a second strand barcode, wherein the first strand barcode and the second strand barcode comprise non-complementary sequences; and
a fragmentation site disposed within the first strand barcode and the second strand barcode.
US Pat. No. 10,246,706

METHODS AND COMPOSITIONS FOR PREVENTING CONCATEMERIZATION DURING TEMPLATE-SWITCHING

New England Biolabs, Inc....

10. A composition comprising:(a) a reverse transcriptase;
(b) an oligonucleotide for template switching, wherein the oligonucleotide comprises a 3? end having at least one nucleotide that can hybridize to one or more non-templated nucleotides added to a templated cDNA strand by the reverse transcriptase; and
(c) polyethylene glycol having an average molecular weight in the range of about 3350 to about 8000.
US Pat. No. 10,247,730

METHOD FOR DETERMINING ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) RELATED BIOMARKERS, A METHOD TO MONITOR THE DEVELOPMENT AND TREATMENT OF ARDS IN A PATIENT

FARON PHARMACEUTICALS OY,...

1. A method for the treatment of a patient suffering from acute respiratory distress syndrome (ARDS), the method comprising:obtaining a serum sample from the patient at a first point in time before administering interferon beta;
treating the patient with interferon beta during a treatment period;obtaining a serum sample from the patient at a later point in time during the treatment period; anddetermining a change in the levels and/or activities of three biomarkers and optionally an additional one to five biomarkers in the serum sample obtained at the first point in time compared to the levels and/or activities of the biomarkers in the serum sample obtained at the later point in time; andwherein the treatment of the patient with interferon beta is continued when the biomarkers each discontinue showing a favorable change, or start to show an unfavorable change;wherein the three biomarkers are CD73, IL-6 and human eotaxin-1 (CCL11) and whereinthe one to five additional biomarkers are selected from the group consisting of interleukin-1 receptor antagonist (IL-1 ra), interleukin-8 (IL-8), interleukin-15 (IL-15), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein (MIP-1a).
US Pat. No. 10,246,707

METHOD FOR EFFICIENT EXON (44) SKIPPING IN DUCHENNE MUSCULAR DYSTROPHY AND ASSOCIATED MEANS

Biomarin Technologies B.V...

1. A single stranded antisense oligonucleotide 16 to 25 nucleotides in length that comprises a base sequence of the sequence selected from the group consisting of SEQ ID NO: 5 to SEQ ID NO: 16, SEQ ID NO: 20 to SEQ ID NO: 28, SEQ ID NO: 30 to SEQ ID NO: 34, SEQ ID NO: 41, and SEQ ID NO: 46, wherein the antisense oligonucleotide induces skipping of exon 44 of human dystrophin pre-mRNA, and comprises a modification.
US Pat. No. 10,247,731

SYSTEM FOR IMMUNOTHERAPY TARGETING TUMOR PROPAGATION AND PROGRESSION

Verik Bio, Inc., Benson,...

1. An isolated tumor C-RC cell population prepared by(a) obtaining a tumor sample from an individual;
(b) cultivating the tumor sample under conditions that induce a stress response in non-C-RC differentiating and differentiated cells leading to apoptosis and necrosis but permit C-RC cells to propagate through the activation of a regenerative response;
(c) isolating the dominant actively expanding, most rapidly dividing population of cells from step (b); and
(d) culturing the cells to obtain a population of 51% to 100% C-RC,
in a serum-free, defined cell culture medium containing agents selected from the group consisting of agents inducing the apoptosis and/or necrosis of the cells, cAMP elevating agents, agents inhibiting cell-cell adhesion, nitric oxide, tumor necrosis factor-alpha (TNF-?), interleukin 1-beta (IL1-?), interferon-gamma (IFN-?), agents disrupting cell adhesion, agents interfering with survival of more differentiated cells, and calcium in a concentration of less than about 1 mM calcium,
wherein 80-100% of the C-RC population consists of actively expanding and dividing VSEC, SDEC and SCEC cells and abnormal transit amplifying cells.
US Pat. No. 10,247,732

MATERIALS AND METHODS FOR DIAGNOSING AND PREDICTING THE COURSE OF PROSTATE CANCER

Indiana University Resear...

1. A method of treating a patient having prostate cancer, the method comprising:identifying the patient as having prostate cancer by detecting an increased expression level of Forkhead-box A1 (FOXA1) in a sample obtained from the patient, wherein the FOXA1 expression level identifies the patient as having prostate cancer; and
treating the patient with at least one compound or a pharmaceutically acceptable salt thereof selected from the group consisting of paclitaxel, docetaxel, cisplatin, methotrexate, cyclophosphamide, 5-fluoro uridine, leucovorin, irinotecan, carboplatin, doxorubicin, fluorouracil carboplatin, edatrexate, gemcitabine, vinorelbine and combinations thereof by administering the at least one compound or the pharmaceutically acceptable salt thereof to the patient.
US Pat. No. 10,247,733

ANTIBODY FOR DETECTING EPITHELIAL OVARIAN CANCER MARKER AND METHOD FOR DIAGNOSING EPITHELIAL OVARIAN CANCER

National Institute of Adv...

1. A method for diagnosis of epithelial ovarian cancer, comprising:(a) quantitatively detecting a ?-1,6-N-acetylglucosaminyltransferase 5B polypeptide fragment present in a sample derived from a test subject using at least one anti-?-1,6-N-acetylglucosaminyltransferase 5B monoclonal antibody, or antibody fragment thereof, and
(b) determining that the test subject is diagnosed to be likely to have epithelial ovarian cancer when the results of quantitatively detecting the ?-1,6-N-acetylglucosaminyltransferase 5B polypeptide fragment are greater than a predetermined cut-off value,
wherein the predetermined cut-off value is the 95th percentile of the quantitative detection results of the ?-1,6-N-acetylglucosaminyltransferase 5B polypeptide fragment in the sample derived from normal individuals or patients other than epithelial ovarian cancer patients,
wherein the anti-?-1,6-N-acetylglucosaminyltransferase 5B monoclonal antibody is produced by a hybridoma identified by International Accession No. FERM BP-11496, FERM BP-11497, FERM BP-11498, or FERM BP-11499.
US Pat. No. 10,246,710

DOUBLE STRAND RNA AS MOLECULAR BIOPESTICIDES FOR RNA INTERFERENCE THROUGH FEEDING IN THE HEMIPTERAN INVASIVE INSECT PEST, BROWN MARMORATED STINK BUG

The United States of Amer...

1. A double-stranded ribonucleic acid (dsRNA) comprising a sense region with at least 95% sequence identity to any one of SEQ ID NOs: 56, 66, 67, or 68 and an antisense region comprising a second sequence complementary to the sense region, wherein said dsRNA is capable of inducing ribonucleic acid interference (RNAi) in an insect.
US Pat. No. 10,247,734

LECTINS AND APPLICATIONS FOR THE DETECTION OF PATHOLOGICAL STATE MARKERS

CENTRE NATIONAL DE LA REC...

1. A monomeric, single polypeptide chain lectin having a ?-propeller architecture, said lectin comprising 4 to 7 peptide modules,wherein each module comprises about 30 to 60 amino acids;
wherein each module comprises a glycan binding site;
wherein at least one glycan binding site comprises at least one mutation, said mutation altering glycan binding;
wherein each module is linked to another module with a peptide linker; and
wherein at least one peptide linker is an exogenous peptide linker.
US Pat. No. 10,248,758

SELF-ASSEMBLING PROTEIN NANOSTRUCTURES

University of Washington ...

17. An isolated nanostructure, comprising(a) a plurality of first proteins that self-interact to form a first multimeric substructure comprising at least one axis of rotational symmetry; and
(b) a plurality of second proteins that self-interact to form a second multimeric substructure comprising at least one axis of rotational symmetry;
wherein multiple copies of the first multimeric substructure and the second multimeric substructure interact with each other at one or more symmetrically repeated, non-natural, non-covalent protein-protein interferences that orient the first multimeric substructures and the second multimeric substructures such that their symmetry axes are aligned with symmetry axes of the same kind in a designated mathematical symmetry group;
wherein the first protein and the second protein comprise proteins selected from the following pairs of first and second proteins:
(a) SEQ ID NOs: 1 and 2;
(b) SEQ ID NOs: 3 and 4;
(c) SEQ ID NOs: 5 and 6;
(d) SEQ ID NOs: 7 and 8; and
(e) SEQ ID NOs: 9 and 10.
US Pat. No. 10,247,479

VORTEX WELL INERTING

1. A method of providing an inerting atmosphere to the surface of molten aluminum in a vortex charge well of a reverberatory melting furnace, the method comprising: introducing a flow of an inerting gas into an inerting region immediately above the surface of the vortex charge well.
US Pat. No. 10,247,735

COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE METABOLISM

The J. David Gladstone In...


where X1 is any amino acid;
ii) a GTPase selected from Rab31 and Rab5; and
iii) a test agent; and
b) determining the effect of the test agent on binding of the intracellular domain of p75NTR to Rab31 or Rab5,
wherein a test agent that inhibits binding of the intracellular domain of p75NTR to Rab31 or Rab5 is a candidate agent for reducing blood glucose levels and/or increasing insulin sensitivity.
US Pat. No. 10,246,456

IRAK4 INHIBITING AGENTS

BIOGEN MA INC., Cambridg...

1. A compound selected from:6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridine-2-amine;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyrimidin-4-amine;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-yl)methanamine;
4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-amine;
5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyrimidin-4-yl)methanamine;
4-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
3-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-5-nitropyridin-2-ol;
3-amino-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-ol;
N-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
N-methyl-1-(3-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)phenyl)methanamine;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinonitrile;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinic acid;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-methylpicolinamide;
2-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyrimidine-4-carbonitrile;
5-(1-(3-chloro-6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(4-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(5-fluoro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(5-methyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinonitrile;
6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
methyl 6-(5-aminopyridin-3-yl)-1-(6-cyanopyridin-2-yl)-1H-indazole-4-carboxylate;
methyl 6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylate;
6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylic acid;
6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
5-(4-(aminomethyl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
(6-(5-aminopyridin-3-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxylate;
(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
6-(6-(1-aminoethyl)pyridin-2-yl)-N,N-dimethyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(5-aminopyridin-3-yl)-N,N-dimethyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
6-(5-aminopyridin-3-yl)-N-methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-amine;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-5,6,7,8-tetrahydroquinolin-8-amine;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N,N-dimethylpicolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-hydroxyethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(3-hydroxypropyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-hydroxypropyl)picolinamide;
(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)(3-hydroxyazetidin-1-yl)methanone;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-(dimethylamino)ethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-cyanoethyl)picolinamide;
N-(2-aminoethyl)-6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(cyanomethyl)picolinamide;
6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)-N-(2-(methylsulfonyl)ethyl)picolinamide;
2-(aminomethyl)-6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
2-(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)acetonitrile;
2-(6-(6-(5-aminopyridin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)acetic acid;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-amino-N-(cyanomethyl)-4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinamide;
1-(5-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-yl)ethanamine;
1-(4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazine-2-carbonitrile;
(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazin-2-yl)methanamine;
4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrimidine-2-carbonitrile;
(4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrimidin-2-yl)methanamine;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyrazin-2-amine;
6-(6-(pyrrolidin-2-yl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole;
6-(6-(1-methylpyrrolidin-2-yl)pyridin-2-yl)-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazole;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
6-(6-(1-aminoethyl)pyridin-2-yl)-N,N-dimethyl-1-(6-methylpyridin-2-yl)-1H-indazol-4-amine;
N-(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)acetamide;
1-(6-(4-(aminomethyl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-((6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)methyl)acetamide;
1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-cyclopropyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(prop-1-en-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-ethyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-isopropyl-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(trifluoromethyl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxylate;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxylic acid;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)methanol;
6-(6-(1-aminoethyl)pyridin-2-yl)-N-methyl-1-(6-methylpyridin-2-yl)-1H-indazole-4-carboxamide;
N-methyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-methyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N-methyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-cyclopropylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-ethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-isopropylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(4-methyl-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-4-(trifluoromethyl)pyridin-2-yl)ethanamine;
6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
cyclopropyl(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
2-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-2-amine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
cyclopropyl(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
1-(6-(1-(4-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(5-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(2-methylthiazol-4-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(1-methyl-1H-imidazol-4-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-4-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-5-yl)methanamine;
(2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-5-yl)methanamine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)isonicotinamide;
N,N-dimethyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
1-(6-methylpyridin-2-yl)-6-(5-(pyrrolidin-1-yl)pyridin-3-yl)-1H-indazole;
6-methyl-5-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
5-(1-(6-cyclopentylpyridin-2-yl)-1H-indazol-6-yl)pyridin-3-amine;
1-(6-(4-fluoro-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
N-(5-(4-cyano-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-3-yl)-2,2,2-trifluoroacetamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-5H-cyclopenta[b]pyridin-7(6H)-one;
6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinonitrile;
2-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)-6,7-dihydroquinolin-8(5H)-one;
6-amino-4-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)picolinic acid;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazole-4-carbonitrile;
1-(6-(4-(aminomethyl)-2-(6-methylpyridin-2-yl)-2H-indazol-6-yl)pyridin-2-yl)ethanamine;
N,N-dimethyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(Z)-1-(6-(4-chloro-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
N,N-dimethyl-1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
tert-butyl (6-(6-acetylpyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)(methyl)carbamate;
(Z)-tert-butyl (6-(6-(1-(hydroxyimino)ethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-yl)(methyl)carbamate;
(Z)-1-(6-(4-(methylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
1-(6-(1-(6-ethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(E)-1-(6-(1-(pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
2-(aminomethyl)-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
N,N-dimethyl-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
(E)-1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
(E)-1-(6-(4-(dimethylamino)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone oxime;
6-(6-(6-acetylpyridin-2-yl)-1H-indazol-1-yl)picolinonitrile;
(E)-methyl 6-(6-(6-(1-(hydroxyimino)ethyl)pyridin-2-yl)-1H-indazol-1-yl)picolinate;
1-(6-(1-(4-methylthiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanone;
1-(6-(4-fluoro-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(3-fluoro-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
methyl 3-amino-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)picolinate;
2,2,2-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
1-(6-(4-ethoxy-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(4-methoxy-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-ol;
6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)picolinamide;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-4-ol;
1-(6-(4-(cyclopropylmethoxy)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)methanamine;
N-((6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)methyl)acetamide;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-3-(trifluoromethyl)pyridin-2-yl)ethanamine;
2-(1-aminoethyl)-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)methanol;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
2,2,2-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanoic acid;
methyl 3-amino-3-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanoate;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclopropanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(R)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
1-(3-chloro-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetamide;
1-(6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
2-(1-aminoethyl)-6-(1-(6-(trifluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-4-amine;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
methyl 2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetate;
2-amino-2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetic acid;
6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)picolinamide;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)propan-2-ol;
1-(6-(1-(6-(methoxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(3-methyl-6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-methylthiophen-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-propylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)oxazol-2-yl)methanamine;
1-(6-(1-(6-(tert-butyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2-methylpropanenitrile;
1-(6-(1-(6-(2-(methylsulfonyl)propan-2-yl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)cyclopropanecarbonitrile;
(6-(6-(6-(aminomethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)propan-2-amine;
(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(4-(1H-imidazol-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-methylpyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-2-amine;
1-(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)ethanol;
(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)methanamine;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2-methylpropanamide;
1-(6-(1-(6-methylpyridin-2-yl)-4-(thiazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclobutanecarbonitrile;
1-(1-methyl-4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-1H-imidazol-2-yl)ethanamine;
1-(6-methylpyridin-2-yl)-6-(pyridin-2-yl)-1H-indazole;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-amine;
(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
1-(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)cyclobutanecarboxamide;
1-(6-methylpyridin-2-yl)-6-(6-(3,3,3-trifluoropropyl)pyridin-2-yl)-1H-indazole;
2-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
1-(6-(1-(4,6-dimethylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-N-methyl-1H-indazole-4-carboxamide;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-4-(1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(4-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)thiazol-2-yl)methanol;
(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-fluoro-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
6-(1-methyl-1H-imidazol-4-yl)-1-(6-methylpyridin-2-yl)-1H-indazole;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(piperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidin-3-ol;
(1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(methylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(ethylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-4-ol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-3-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoroazetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-3-(chloromethyl)azetidin-3-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoropyrrolidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(2-methylmorpholino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(2,6-dimethylmorpholino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
3-((6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)amino)-2-(chloromethyl)propanoic acid;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)thiomorpholine 1,1-dioxide;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-thiomorpholino-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-morpholino-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-dimethylazetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)pyrrolidine-3-carboxylic acid;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(pyrrolidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(4-methylpiperazin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((3-chloro-2,2-dimethylpropyl)amino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(azetidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(4,4-difluoropiperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,3-difluoropiperidin-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)azetidine-3-carboxylic acid;
1-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidine-3-carboxylic acid;
(S)-1-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidine-4-carboxylic acid;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)morpholin-3-one;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-methyl-1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-imidazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-1,2,4-triazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-(trifluoromethyl)-1H-pyrazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-ethylpyridin-2-yl)-4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(oxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyl-1,3,4-thiadiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-imidazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methylthiazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-2-(6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)thiazole-4-carbonitrile;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(isothiazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-phenyl-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-(trifluoromethyl)oxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-methylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4,5-dimethylthiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4-(trifluoromethyl)thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-(trifluoromethyl)thiazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-(trifluoromethyl)thiazol-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-(trifluoromethyl)-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-fluoropyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(difluoromethyl)-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(1-(difluoromethyl)-1H-pyrazol-5-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(4-(1,5-dimethyl-1H-pyrazol-3-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(pyridazin-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidin-2-yl)methanol;
(S)-(3-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)phenyl)methanol;
(S)-(2-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidin-4-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(2-(1-aminobutyl)pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(2-(1-aminobutyl)pyrimidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-aminobutyl)pyrazin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-methoxy-1H-indazol-6-yl)pyridin-2-yl)butan-1-01;
(S)-(6-(6-(4-(1-aminoethyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminoethyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(6-(6-((S)-1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)ethanol;
deutero (S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(8-amino-8-methyl-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(8-amino-8-propyl-5,6,7,8-tetrahydroquinolin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclobutyl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1-methylpiperidin-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(tetrahydro-2H-pyran-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-2-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)ethanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyrazin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4S)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4R)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4S)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(4R)-4-amino-3-fluoro-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(6-(6-(6-((1R)-1-amino-2-fluoropropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1S)-1-amino-2-fluoropropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobut-3-en-1-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3-methylbut-3-en-1-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(amino(phenyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(phenyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopent-3-yn-1-yl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2S)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2R)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(amino(oxetan-3-yl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(amino(oxetan-3-yl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-amino-2-(3-methyloxetan-3-yl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-one;
(S)-6-(6-(6-(1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)picolinaldehyde;
(R)-1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroethanol;
(S)-1-(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroethanol;
(6-(6-(6-((1R,2R)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((1R,2S)-1-amino-2-fluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3,3-difluorobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(3-methoxypropoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-3-((6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-3-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-3-((6-(6-(1-aminopropyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)propan-1-ol;
(S)-4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-2-methylbut-3-yn-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(3-aminooxetan-3-yl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(3-aminotetrahydrofuran-3-yl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminocyclobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(6-(6-(6-(1-aminocyclopentyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-(methylsulfonyl)ethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-((6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)oxy)-2-methylpropan-2-ol;
6-{6-[6-((S)-1-Amino-ethyl)-pyridin-2-yl]-indazol-1-yl}-pyridine-2-carboxylic;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(6-{6-[6-((S)-1-Amino-ethyl)-pyridin-2-yl]-4-fluoro-indazol-1-yl}-pyridin-2-yl)-methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(tetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((2R,5R)-5-methyltetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((2S,5R)-5-methyltetrahydrofuran-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(6-{6-[6-((S)-1-Amino-butyl)-pyridin-2-yl]-4-isopropoxy-indazol-1-yl}-pyridin-2-yl)-methanol;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(methylamino)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(fluoromethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-chloro-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(difluoromethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)methanol;
(S)-(6-(6-(6-(1-aminopentyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(3,6-dihydro-2H-pyran-4-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(methoxymethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((difluoromethoxy)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(morpholinomethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-1-(6-(4-methoxy-1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(4-ethoxy-1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(piperidin-3-ylmethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-amino-1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4,4,4-trifluorobutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2,2,2-trifluoroethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(4-(6-(6-(1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)piperidin-1-yl)ethanone;
1-amino-1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((dimethylamino)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(fluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(1-amino-2-(methylthio)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-3-methylbutyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(2-cyclopropylethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(trifluoromethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(4,5-dihydrooxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-2-ol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(difluoromethoxy)-1H-indazol-1-yl)pyrazin-2-yl)methanol;
(S)-(6-(6-(6-(1-(methylamino)butyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminoethyl)pyridin-2-yl)-4-(4-methyl-4,5-dihydrooxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanol;
(S)-1-(6-(1-(4-(trifluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(1-amino-2-(methylsulfonyl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-6-(6-(1-aminopropyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(6-(6-(6-(1-amino-2-cyclopropylethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
1-(6-(1-(6-methylpyridin-2-yl)-4-(oxazol-5-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(S)-6-(6-(1-aminoethyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carbonitrile;
(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(difluoromethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
(S)-6-(6-(1-aminoethyl)pyridin-2-yl)-N-(1-hydroxy-2-methylpropan-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyridin-2-yl)-4-(oxazol-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
(6-(6-(6-(1-amino-2-methoxyethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)-N,N-dimethylacetamide;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)-3-fluoropyridin-2-yl)methanol;
(S)-1-(6-(1-(6-(trifluoromethyl)pyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
6-(6-((S)-1-aminoethyl)pyridin-2-yl)-N-(2-aminopropyl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazole-4-carboxamide;
1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
1-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-ol;
3,3,3-trifluoro-1-(6-(1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propan-1-amine;
1-(6-(4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-(6-methylpyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
1-(6-(1-(6-methylpyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)ethanamine;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetonitrile;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)acetamide;
4-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)pyrimidine-2-carbonitrile;
(6-(6-(3-(1-aminoethyl)phenyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-(1-aminoethyl)-3-fluoropyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-1H-indazol-1-yl)-5-fluoropyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-(dimethylamino)butyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-amino-2-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)-N-methylacetamide;
(6-(6-(6-(1-amino-2-(methylsulfinyl)ethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(1-methoxyethyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(4-chloro-1-(4-(difluoromethyl)pyrimidin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-(pyrrolidin-2-yl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(4-(difluoromethyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-((S)-pyrrolidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-amino-4-methoxybutyl)pyridin-2-yl)-4-(1-methyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-methoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(5-methyloxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((trifluoromethoxy)methyl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminopentyl)pyrimidin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-3-amino-3-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanenitrile;
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-(5-methyloxazol-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-ethoxy-1H-indazol-1-yl)pyridin-2-yl)methanol;
2-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-4-yl)-3-chloropropan-1-ol;
(S)-(6-(6-(6-(1-aminoethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(1-aminopropyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(6-(amino(cyclopropyl)methyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-1-(6-(1-(6-methylpyrazin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butan-1-amine;
(S)-3-amino-3-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)propanenitrile;
(S)-4-amino-4-(6-(1-(6-(hydroxymethyl)pyridin-2-yl)-1H-indazol-6-yl)pyridin-2-yl)butanenitrile;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(1,5-dimethyl-1H-pyrazol-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(6-(1-amino-2-fluoroethyl)pyridin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(S)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(R)-(6-(6-(4-(1-aminobutyl)pyrimidin-2-yl)-4-(2-methoxyethoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
(6-(6-(6-((S)-1-aminobutyl)pyridin-2-yl)-4-(tetrahydrofuran-3-yl)-1H-indazol-1-yl)pyridin-2-yl)methanol; and
(S)-(6-(6-(6-(1-aminobutyl)pyridin-2-yl)-4-((3,3-difluorocyclobutyl)methoxy)-1H-indazol-1-yl)pyridin-2-yl)methanol;
or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,246,712

GENETIC OR PHARMACOLOGICAL REDUCTION OF PERK ENHANCES CORTICAL- AND HIPPOCAMPUS-DEPENDENT COGNITIVE FUNCTION

Carmel-Haifa University E...

1. A method for improving a cognitive function in a subject having age-related cognitive dysfunction, said method comprising administering to said subject an active agent reducing PKR-like endoplasmic reticulum kinase (PERK) activity.
US Pat. No. 10,247,736

IDENTIFICATION AND QUANTIFICATION OF BIOMARKERS FOR EVALUATING THE RISK OF PRETERM BIRTH

BRIGHAM YOUNG UNIVERSITY,...

1. A method of identifying subjects at risk for preterm birth, the method comprising the steps of:(a) protein depleting a serum or blood sample from a pregnant subject, wherein the protein depleting includes treating the serum or blood sample with a volume of acetonitrile;
(b) fractionating the protein depleted sample to isolate at least one biomarker selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3;
(c) detecting a concentration of the at least one isolated biomarker by mass spectrometry; and
(d) identifying the pregnant subject as being at risk for preterm birth when the concentration of the at least one isolated biomarker is less than a control concentration of the at least one biomarker.
US Pat. No. 10,246,713

TMPRSS6 IRNA COMPOSITIONS AND METHODS OF USE THEREOF

Alnylam Pharmaceuticals, ...

1. A double stranded RNAi agent for inhibiting expression of TMPRSS6 in a cell, wherein said double stranded RNAi agent comprises a sense strand and an antisense strand forming a duplex, wherein the sense strand comprises any one of the modified nucleotide sequences selected from the group consisting of SEQ ID NOS: 62-86, 112-127, and 144-147, and the antisense strand comprises any one of the modified nucleotide sequences selected from the group consisting of SEQ ID NOS: 87-111, 128-143, and 148-151, and wherein the sense strand is 21 nucleotides in length and the antisense strand is 23 nucleotides in length.
US Pat. No. 10,247,737

KITS FOR CLASSIFYING A SUBJECT HAVING OR AT RISK FOR DEVELOPING IDIOPATHIC SCOLIOSIS

Chu Sainte-Justine, (CA)...

1. A kit for classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising:(a) a purified recombinant osteopontin (rOPN) preparation; and
(b) a ligand for Gi stimulation;
wherein said kit optionally further comprises in addition to (a) and (b),
(c) a ligand for Gs stimulation; and/or
(d) one or more antibodies for detecting Gi? phosphorylation.
US Pat. No. 10,247,738

DIAGNOSING AND TREATING ALZHEIMERS DISEASE

DIGNITY HEALTH, San Fran...

1. A method of diagnosing late onset Alzheimer's disease (LOAD) in an individual, comprising:obtaining a cerebrospinal fluid sample from the individual;
preparing the sample to be assayed by a serological test to determine the presence or absence of low PACAP expression levels;
diagnosing LOAD based on the presence of low PACAP protein levels relative to those levels found in a healthy subject; and
administering a composition comprising PACAP to the individual when the PACAP protein expression level in the individual's cerebrospinal fluid is below levels found in the healthy subject.
US Pat. No. 10,246,715

CPG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION INCLUDING THE SAME, AND METHOD OF INDUCING IMMUNE RESPONSE BY THE SAME

National Health Research ...

1. A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host, comprising:one or more copies of the sequence of GTCGTT;
one or more copies of the sequence of GTT; and
one or more copies of the sequence of TTTT;
wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT, and
the CpG-ODN comprises the sequence of SEQ ID NO: 1.
US Pat. No. 10,247,739

METHOD FOR IMMUNOLOGICAL MEASUREMENT USING A HAPTEN AND ANTIBODY BINDING TO THE HAPTEN AS REFERENCE ANTIBODY AND DEVICE FOR IMMUNOLOGICAL MEASUREMENT USING THE REFERENCE ANTIBODY

SK TELECOM CO., LTD., Se...

1. A method for the immunological measurement of a test substance in a sample using a hapten and a hapten antibody binding to the hapten, comprising the steps ofallowing the test substance in the sample to bind to a test probe specific to the test substance to form a complex of the test substance and the test probe in a conjugate zone, and
allowing the hapten or the hapten antibody to bind to a reference probe specific to the hapten or the hapten antibody to form a complex of the hapten and the reference probe or a complex of the hapten antibody and the reference probe in the conjugate zone;
spreading the complex of the test substance and the test probe to a test zone, and allowing the complex of the test substance and the test probe to bind to a capture antibody against the test substance;
spreading the complex of the hapten and the reference probe or the complex of the hapten antibody and the reference probe to the reference zone, and allowing the complex of the hapten and the reference probe or the complex of the hapten antibody and the reference probe to bind to the hapten antibody or the hapten;
measuring a detectable signal emitted by the test probe in the test zone through binding with the capture antibody and the reference probe in the reference zone through binding with the hapten or the hapten antibody; and
analyzing the signal to measure the test substance in the sample,
wherein the hapten antibody comprises i) a heavy-chain variable region CDR1 having an amino acid sequence set forth in SEQ ID NO: 3, ii) a heavy-chain variable region CDR2 having an amino acid sequence set forth in SEQ ID NO: 4, iii) a heavy-chain variable region CDR3 having an amino acid sequence set forth in SEQ ID NO: 5, iv) a light-chain variable region CDR1 having an amino acid sequence set forth in SEQ ID NO: 6, v) a light-chain variable region CDR2 having an amino acid sequence set forth in SEQ ID NO: 7, and vi) a light-chain variable region CDR3 having an amino acid sequence set forth in SEQ ID NO: 8.
US Pat. No. 10,246,716

WHEAT WITH INCREASED RESISTANT STARCH LEVELS

ARCADIA BIOSCIENCES, INC....

1. A wheat plant of the species Triticum aestivum comprising one or more homozygous severe mutations in both SBEIIa alleles of each SBEIIa gene of the A, B, and D genomes, wherein said wheat plant produces grain that germinates, and further wherein grain from said wheat plant has an increased amylose level as compared to grain from a wild type wheat plant.
US Pat. No. 10,246,717

WHEAT WITH INCREASED RESISTANT STARCH LEVELS

ARCADIA BIOSCIENCES, INC....

1. A wheat plant of the species Triticum turgidum L. ssp durum comprising one or more homozygous severe mutations in both SBEIIa alleles of each SBEIIa gene of the A and B genomes, wherein said wheat plant produces grain that germinates, and wherein the grain from said wheat plant has an increased amylose level as compared to grain from a wild type wheat plant.
US Pat. No. 10,246,718

PROCESSES FOR PRODUCING LIPIDS

THE COMMONWEALTH SCIENTIF...

1. A process for feeding an animal, comprising a step of providing to the animal a vegetative plant part from a transformed plant, the vegetative plant part comprising one or more exogenous polynucleotides which encode at least Wrinkled 1 (WRI1) and a fatty acid acyltransferase and having a total non-polar lipid content of at least 10% (w/w dry weight).
US Pat. No. 10,246,719

MODULATING LACCASE ENZYME TO REGULATE CELL WALL BIOSYNTHESIS AND RECALCITRANCE IN PLANTS

UT-BATTELLE, LLC, Oak Ri...

1. A genetically modified plant characterized by a reduced expression of the LAC2 gene as compared to a control plant, wherein the genetic modification is specifically targeted at the LAC2 gene or the LAC2 mRNA to reduce the LAC2 gene expression.
US Pat. No. 10,247,743

ANALYTE TESTING AUTOMATION SYSTEM, BIOLOGICAL SAMPLE CHECK MODULE, AND BIOLOGICAL SAMPLE CHECK METHOD

Hitachi High-Technologies...

1. An analyte testing automation system comprising:a camera configured to capture an image of a container, in which a biological sample is stored, from a side thereof;
a grip member configured to grasp and lift the container;
a database which stores a plurality of different container types that specify a plurality of different lifting operation parameters and a plurality of different threshold parameters;
a controller coupled to the camera and the grip member, and programmed to:
control the camera to capture a first image of the container,
determine a container type of the container from among the different container types stored in the database according to a length, a diameter and a cap color of the container in the first image,
determine a lifting operation parameter and a threshold parameter of the container from the different lifting operation parameters and the different threshold parameters in the database specified by the determined container type,
control the grip member to lift the container to a predetermined height specified by the lifting operation parameter,
capture a second image of the container in a state where the container is lifted to the predetermined height by the grip member,
compare the second image to one or more predetermined color values specified by the threshold parameter, and
determine a state of an analyte in the biological sample in the container from the comparison.
US Pat. No. 10,246,720

PLANTS HAVING ENHANCED NITROGEN EFFICIENCY

BAYER INTELLECTUAL PROPER...

1. A transgenic monocot plant, plant cell or plant part comprising a polynucleotide encoding an alanine aminotransferase comprising the amino acid sequence of SEQ ID No. 3 operably linked to a PBpr1 promoter comprising the nucleotide sequence of SEQ ID No. 1.
US Pat. No. 10,246,721

SUGAR TRANSPORTERS

Carnegie Institution of W...

1. A method of inhibiting the expression or activity of a SWEET transporter in a plant cell, the method comprising transforming the plant cell with an expression vector, the expression vector comprising a nucleic acid sequence coding for one or more polynucleotides that form a double-stranded RNA (dsRNA) to inhibit a nucleic acid sequence in the plant cell coding for at least one of a SWEET4 transporter, a SWEET15 transporter, and a SWEET17 transporter, wherein said nucleic acid sequence is expressed in said plant cell, which, when said nucleic acid sequence is expressed said dsRNA is formed, wherein said dsRNA reduces sugar efflux out of the plant cell, wherein the plant cell is from or in soybean, rice, tomato, alfalfa, potato, pea, grasses, herbs, trees, algae, mosses, fungi, vines, ferns, bushes, barley, wheat, hops, maize, lettuce, orange, peach, citrus, lemon, lime, coconut, palm, pine, oak, cedar, mango, pineapple, rhubarb, strawberry, blackberry, blackcurrant, blueberry, raspberry, kiwi, grape, rutabaga, parsnip, sweet potato, turnip, pepper, cilantro, onion, leek, fennel, clove, avocado, cucumber, Miscanthus, poplar, sorghum, or Brachypodium, wherein the reduction in efflux of sugar out of the plant cell increases pathogen resistance of the plant cell to Botrytis cinerea.
US Pat. No. 10,247,745

GLYCAN SAMPLE PREPARATION

Beckman Coulter, Inc., B...

1. A method of analyzing one or more glycoconjugates, comprising:reacting a sample containing one or more glycoconjugates with a deglycosylation reagent to release glycans from the glycoconjugates;
associating the glycans with a plurality of magnetic particles;
applying a magnetic field to draw down the plurality of magnetic particles having the glycans associated therewith;
removing a supernatant from the drawn-down magnetic particles so as to remove the deglycosylation reagent and deglycosylated sample;
reacting the glycans with a labeling reagent so as to form labeled glycans;
analyzing the labeled glycans;
wherein the magnetic particles are carboxyl-coated magnetic beads; and
wherein the glycans are associated with the plurality of magnetic particles by adding acetonitrile.
US Pat. No. 10,246,722

CROP RESISTANCE TO NEMATODES

The Curators of the Unive...

1. A method for inhibiting plant parasitic nematode damage to a soybean plant, said method comprising:(1) reducing the expression of an endogenous plant RECEPTOR-LIKE PROTEIN KINASE 2 (RPK2)-like gene by expressing in said soybean plant RNAi to silence said RPK2-like gene, wherein said RPK2-like gene is set forth in SEQ ID NO:17, SEQ ID NO: 18, SEQ ID NO: 20 or SEQ ID NO: 21; and
(2) growing said soybean plant expressing said RNAi,
thereby inhibiting plant parasitic nematode damage to said soybean plant.
US Pat. No. 10,246,723

METHOD FOR PROPAGATING STERILE MALE PLANT LINE

China Agricultural Univer...

1. A nucleotide construct comprising:a first nucleotide sequence comprising a wild type allele of a male fertility regulatory gene Ms45; and
a second nucleotide sequence, wherein the second nucleotide sequence comprises a nucleotide sequence that inhibits the expression of the protein presented by SEQ ID No:5, wherein the nucleotide sequence that inhibits the expression of the protein presented by SEQ ID No:5 comprises SEQfor-X-SEQrev;
wherein the SEQfor comprises the nucleotide sequence of positions 14-276 of SEQ ID No:2; the SEQrev comprises the nucleotide sequence of positions 401-663 of SEQ ID NO:2; and the X is an intron forming a hairpin structure and comprises the nucleotide sequence of positions 277-400 of SEQ ID No:2.
US Pat. No. 10,246,725

MICROORGANISMS AND METHODS FOR PRODUCING PYRUVATE, ETHANOL, AND OTHER COMPOUNDS

WISCONSIN ALUMNI RESEARCH...

1. A microorganism comprising activity-reducing or activity-ablating mutations in endogenous genes encoding pyruvate dehydrogenase, pyruvate oxidase, succinate dehydrogenase, and 6-phosphogluconate dehydrogenase.
US Pat. No. 10,244,934

ATHERECTOMY CATHETER DRIVE ASSEMBLIES

Avinger, Inc., Redwood C...

11. A drive assembly for driving an imaging catheter having a rotatable fiber, the drive assembly comprising:a fiber optic rotating junction having a stationary portion with a stationary fiber therein and a rotatable portion with a rotatable fiber therein;
a first optical connector configured to connect the stationary fiber with a light source;
a motor configured to simultaneously rotate the rotatable portion of the fiber optic rotating junction and a rotatable shaft of the catheter, the motor having a shaft that is coaxial with a fiber of the fiber optic rotating junction; and
a second optical connector configured to connect the rotatable portion of the fiber optic rotating junction with the rotatable fiber of the imaging catheter so as to allow torque to simultaneously be transmitted from the motor to the rotatable shaft and the rotatable fiber of the catheter and so as to allow light to be transmitted from the light source to the rotatable fiber of the catheter.
US Pat. No. 10,246,470

HETEROCYCLIC COMPOUNDS

CADILA HEALTHCARE LIMITED...

1. A compound (3S)-3-(4-((3-(6-Oxa-3-azabicyclo[3.1.1]heptan-3-ylmethyl)benzyl)oxy)phenyl)hex-4-ynoic acid or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,246,726

PHOTOSYNTHETIC PRODUCTION OF 3-HYDROXYBUTYRATE FROM CARBON DIOXIDE

ARIZONA BOARD OF REGENTS ...

1. A method of photosynthetic production of 3-hydroxybutyrate comprising culturing a Synechocystis cyanobacterium under conditions to produce said 3-hydroxybutyrate;wherein said Synechocystis cyanobacterium is genetically engineered to overexpress the gene phaA2 and one or more of the genes phaB2, phaA, phaB, thil, hbd, and tesB and wherein the genes phaC and phaE have been inactivated or deleted; or
wherein said Synechocystis cyanobacterium is genetically engineered to overexpress the gene phaA2 and at least one of a phaA or a thil gene, at least one of a phaB or hbd gene, and a tesB gene, and wherein the genes phaC and phaE have been inactivated or deleted.
US Pat. No. 10,246,727

FERMENTATION ROUTE FOR THE PRODUCTION OF LEVULINIC ACID, LEVULINATE ESTERS AND VALEROLACTONE AND DERIVATIVES THEREOF

ARZEDA CORP., Seattle, W...

1. A method for producing 2-oxo-4-valerolactone, the method comprising: converting pyruvate to 4-hydroxy-2-oxo-pentanoic acid by aldol addition, and converting 4-hydroxy-2-oxo-pentanoic acid to 2-oxo-4-valerolactone through lactonization.
US Pat. No. 10,246,728

VARIANT THIOESTERASES AND METHODS OF USE

CORBION BIOTECH, INC., S...

1. A non-natural fatty acyl-ACP thioesterase wherein the non-natural thioesterase has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to SEQ ID NO: 1 and comprises:i) Tyrosine (Y) or phenylalanine (F) at the position corresponding to position 163 of SEQ ID NO: 1 and lysine (K), or alanine (A) at the position corresponding to position 186 of SEQ ID NO: 1; or
ii) Phenylalanine (F) at the position corresponding to position 163 of SEQ ID NO: 1 and/or proline (P), lysine (K), or alanine (A) at the position corresponding to position 186 of SEQ ID NO: 1, wherein the non-natural thioesterase catalyzes the production of increased levels of C8:0 and C10:0 fatty acids in comparison to a wild-type thioesterase.
US Pat. No. 10,246,473

PROCESS FOR PREPARING AN ACRYLOYLOXYSILANE

Dow Corning Corporation, ...

1. A process for purifying an acryloyloxysilane, the process comprising:subjecting a mixture comprising an acryloyloxysilane, a haloorganoalkoxysilane, and a non-polar solvent, wherein the non-polar solvent comprises a mixture of 0.5 to 15% (w/w) of a branched-chain alkane having from 5 to 20 carbon atoms and 85 to 99.5% (w/w) of a straight-chain alkane having from 5 to 14 carbon atoms, based on the weight of the branched-chain and straight-chain alkane in the non-polar solvent, and wherein the non-polar solvent comprises less than 5% (w/w), based on the weight of the non-polar solvent, of an aromatic compound, to a temperature and pressure sufficient to vaporize a portion of the non-polar solvent, the haloorganoalkoxysilane, or the non-polar solvent and the haloorganoalkoxysilane from the mixture to produce a purified mixture comprising the acryloyloxysilane.
US Pat. No. 10,246,729

PROCESS FOR THE RECOVERY OF BETAINE FROM MOLASSES

TIENSE SUIKERRAFFIINADERI...

1. A process for the recovery of betaine from a sugar beet molasses said method comprising the steps of:providing a starting material containing between 45 and 65 wt. % sucrose, between 3 and 8 wt. % betaine, between 6 and 10 wt. % amino acids, as well as fructose, glucose and inorganic salts, wherein the starting material comprises a sugar beet molasses by-product formed in a process for preparation of sucrose,
a conversion step, in which the sugar beet molasses starting material is first subjected to the action of a fructan-forming enzyme, having endo-inulinase activity and/or fructosyltransferase activity, whereby at least 80 wt % of the sucrose contained in the sugar beet molasses is converted to form a fructo-oligosaccharide- containing molasses (FOS-molasses); and
a separation step, in which the FOS-molasses from the conversion step is subjected to a chromatographic separation, thereby obtaining a betaine-containing fraction having a ratio of betaine to other dry-matter constituents of the FOS-molasses of at least 70:30, wherein:
prior to the separation step the FOS-molasses from the conversion step is heated to a temperature of between 80-90° C. and held at such temperature for between 5 and 30 minutes to deactivate the enzyme and reduce any bacteria that may be present in the FOS-molasses,
the separation step is accomplished by ion-exchange chromatography in a simulated moving bed chromatography system,
a cation exchange resin is used in the ion-exchange chromatographic separation step, and
prior to the separation step the molasses or the fructan-molasses is subjected to an ion-exchange step, whereby the concentration of those cations in the molasses or in the fructan-molasses that are different from the cation exchange resin, is reduced by at least 90%.
US Pat. No. 10,250,060

ADAPTIVE CHARGE CONTROL CIRCUIT AND CONTROL METHOD FOR SWITCHING CHARGER

Silergy Semiconductor Tec...

1. An adaptive charge control circuit configured for a switching charger, the control circuit comprising:a) an input voltage control circuit configured to receive an input voltage signal of said switching charger and an input voltage reference signal, and to generate a first error signal;
b) an input current control circuit configured to receive an input current signal of said switching charger and an input current reference signal, and to generate a second error signal;
c) a charging current control circuit configured to receive a charging current signal of said switching charger and a charging current reference signal, and to generate a third error signal;
d) a charging voltage control circuit configured to receive a charging voltage signal of said switching charger and a charging voltage reference signal, and to generate a fourth error signal;
e) a minimum value selector configured to select a minimum one of said first, second, third, and fourth error signals to control switching operations of a power switch in said switching charger; and
f) a reference current regulating circuit configured to regulate, based on a comparison of said first error signal against said second, third, and fourth error signals, said input current reference signal of said input current control circuit until said first error signal is at least as high as any of said second, third, and fourth error signals, wherein said reference current regulating circuit gradually reduces said input current reference signal when said input voltage control circuit operates until said input voltage control circuit stops operating.
US Pat. No. 10,245,451

AMINOFUNCTIONAL ORGANOSILOXANES

Dow Silicones Corporation...

1. A method of treating a surface of a fiber, the method comprising applying an aqueous emulsion to the surface of the fiber, wherein the aqueous emulsion comprises:A) an aminofunctional silicone composition comprising an organopolysiloxane having an average formula:
(CH3)3SiO[(CH3)2SiO]x[(CH3)RNSiO]ySi(CH3)3
with less than 1 weight % of nitrogen in its formula,
where RN is an aminofunctional group, x is ?100, and y is ?1, with the proviso that the sum of x+y is from 250 to 350; and
B) a quaternary ammonium surfactant having a formula:
R1R2R3R4N+X?,
where R1 is a radical containing at least 10 carbon atoms, R2 is R1 or a hydrocarbyl containing 1 to 12 carbon atoms, R3 is R1, R2, or an alcohol group containing 2 to 10 carbon atoms, R4 is R1, R2, or R3, and X? is a halide, sulfate, sulfonate, methosulfate, or ethosulfate;
wherein the viscosity of A) the aminofunctional silicone composition ranges from 1000 to 2500 cP at 25° C. as measured by a Brookfield RV DV viscometer equipped with Pro CP 52 spindle at 20 RPM;
wherein A) the aminofunctional silicone composition contains less than 0.1 weight % of octamethylcyclotetrasiloxanes (D4) and less than 0.1 weight % decamethylcyclopentasiloxanes (D5) cyclic siloxanes; and
wherein B) the quaternary ammonium surfactant is present in the aqueous emulsion in an amount of at least 0.5 weight %.
US Pat. No. 10,246,731

METHOD FOR RAPIDLY DETERMINING EFFECTIVE STERILIZATION , DEIMMUNIZATION, AND/OR DISINFECTION

representative of an infectious agent potentially contaminating the equipment and/or the supplies to be sterilized, deimmunized, and/or disinfected by the device;subjecting the defined surrogate protein having the predetermined sequence to sterilization, deimmunization, or disinfection; and
determining the effectiveness of the sterilization, deimmunization, and/or disinfection by determining if the defined surrogate protein having the predetermined sequence has been destroyed; and wherein the sterilization, deimmunization, and/or disinfection occurs when the defined surrogate protein has been fragmented to yield a negative result in a protein analysis procedure.
US Pat. No. 10,246,476

METHOD FOR PREPARING D-PSICOSE CRYSTAL

CJ CHEILJEDANG CORPORATIO...

1. A method for producing D-psicose crystals having a grain size of MA200 ?m or larger, comprising:removing impurities from a D-psicose solution to obtain a purified D-psicose solution;
concentrating the purified D-psicose solution to provide a concentrated D-psicose solution having a concentration of 80 Brix (%) to 85 Brix (%);
performing rapid cooling of the concentrated D-psicose solution to 30° C. to 40° C. in a heat exchanger to provide a copied D-psicose solution having a temperature between 3° C. and 4° C., wherein the rapid cooling is performed at a cooling rate of 5° C. to 20° C. per hour;
placing the cooled D-psicose solution at a temperature between 30° C. and 40° C. to a crystallizer and adding D-psicose seed crystals to the crystallizer;
performing seeded crystallization of D-psicose in the crystallizer while controlling temperature to stay between 30° C. and 40° C., which provides a D-psicose massecuite having a temperature between 30° C. and 40° C.; and
performing full-scale crystallization of D-psicose using the D-psicose massecuite while controlling temperature to stay between 30° C. and 40° C., which provides D-psicose crystals having a grain size of MA200 ?m or larger.