US Pat. No. 10,212,919

SILICONE CHEW TOY

Funzone, Inc., Los Angel...

1. A silicone chew toy comprising:a base layer, made from a solid silicone material of a first color, comprising a first side and a second side, a thickness of at least 8 millimeters between the first and second sides, a minimum width of at least 38 millimeters, and a minimum length of at least 38 millimeters; and
a first layer, made from a liquid silicone material of a second color, formed and vulcanized on the first side of the base layer, the first layer having a thickness of at least 0.5 millimeters, wherein the first color is different from the second color,
wherein the silicone chew toy comprising the base and first layers can withstand at least 100 pounds of bite pressure for at least 10 seconds without breakage.

US Pat. No. 10,212,918

PET URINE PAD CONVENIENT TO TAKE AS WELL AS PRODUCTION METHOD AND PROCESSING EQUIPMENT THEREOF

Jiangsu Zhongheng Pet Art...

1. A processing equipment of a pet urine pad convenient to carry, comprising:a pet urine pad processing main machine frame;
a conveying device arranged on the pet urine pad processing main machine frame; and
a buffer device frame arranged at a rear end of the pet urine pad processing main machine frame,
wherein a buffer device is arranged on the buffer device frame,
wherein a folding device frame is arranged at a rear end of the buffer device frame,
wherein a transverse traction device is arranged on one side of a front end of the folding device frame,
wherein a vertical traction device is arranged in a middle of an upper end of the folding device frame,
wherein a point-breaking device is arranged on the folding device frame at a lower end of the vertical traction device,
wherein a folding device is arranged on the folding device frame at a lower end of the point-breaking device, and
wherein a structure of the folding device comprises two folding rollers symmetrically arranged on the folding device frame through rotating shafts, respectively, wherein the two folding rollers are identical in structure and matched with each other, a folding notch is configured in one side of each folding roller, a blade is arranged on the other side of the corresponding folding roller, a rotating arm is rotatably arranged on each folding roller through a revolving shaft and equipped with a limiting pillar, barrier pillars matched with the corresponding limiting pillars to each other are arranged on the folding device frame, a folding hook is connected to one end of each rotating arm, a hook part of each folding hook is arranged in the corresponding folding notch, and the other end of the corresponding rotating arm is arranged on the corresponding folding roller through a spring.

US Pat. No. 10,212,917

CAT ATTRACTANT

Kent Pet Group, Inc., Mu...

1. An animal litter comprising discrete plural particles of a sorbent material and a cat attractant, the cat attractant being present in an amount of 1 to 5% by weight of said animal litter and comprising a mixture of alfalfa meal and an acidic plant fiber, the alfalfa meal being present in an amount of at least 60% by weight relative to the weight of the acidic plant fiber.

US Pat. No. 10,212,916

LIGHTWEIGHT CLUMPING ANIMAL LITTER AND METHODS THEREOF

The Clorox Company, Oakl...

1. A method of making composite particles having a cellulosic material component and a sodium bentonite component comprising:providing flat-shaped cellulosic particles having a mean particle size ranging from 0.2-3 mm;
providing powdered sodium bentonite particles having a mean particle size less than 0.25 mm, wherein the ratio of cellulosic material to sodium bentonite is in the range of 1:4 to 4:1;
using a high shear agglomeration process to mix the cellulosic particles and the sodium bentonite particles to form composite particles having a mean particle size in the range of 0.4-4 mm.

US Pat. No. 10,212,915

SYSTEM AND METHOD FOR AUTOMATICALLY FLUSHING PET URINE FROM A LITTER BOX

1. An automatic urine flushing pet litter box system, comprising:an upper litter tray with a perforated bottom configured to drain discharged urine;
a lower liquid holding tank nested below the upper litter tray configured to hold holding water such that holding water and discharged urine are collected in the lower liquid holding tank, the lower liquid holding tank further including a plurality of chargers and a plurality of sensors to detect multiple liquid levels in the holding tank,
a drainpipe coupled to the lower liquid holding tank and configured to drain the holding water and the discharged urine into a drain;
a first valve coupled to the drainpipe configured to vacuum the holding water and the discharged urine from the lower liquid holding tank in response to at least one of the detected water levels;
a water intake pipe coupled to the lower liquid holding tank; and
a second valve coupled to the water intake pipe configured to deliver water to the lower liquid holding tank in response to at least one of the detected water levels;
wherein the plurality of chargers and plurality of sensors further comprise,
a first charger and first sensor each disposed at the bottom of the liquid holding tank with the first charger disposed at a position lower than the first sensor in relation to the height of the liquid holding tank,
a second charger and second sensor each positioned at the same height in relation to the height of the liquid holding tank above each of the first sensor and the first charger, the second charger and the second sensor configured to control the first valve to drain liquid from the liquid holding tank when the liquid level reaches a maximum level in the liquid holding tank,
a third charger and third sensor each positioned at the same height in relation to the height of the liquid holding tank above each of the second sensor and the second charger, the third charger and the third sensor configured to prevent an overflow of liquid from the liquid holding tank by preventing the second valve delivering water to the liquid holding tank, and
a fourth sensor positioned above the first charger and the first sensor and below the second charger and the second sensor in relation to the height of the liquid holding tank, the fourth sensor configured to provide a maximum water level for the liquid holding tank, the first sensor and the fourth sensor configured to control the second valve to fill the liquid holding tank with water.

US Pat. No. 10,212,914

CIRCULATION SYSTEM AND METHOD OF CIRCULATION

1. A ventilation system for installation in a poultry house with house air, the ventilation system comprising:an outside intake air inlet wherein the outside intake air inlet draws in intake air from outside the poultry system;
a screen connected to the outside intake air inlet, the screen positioned to screen the intake air;
a house air inlet wherein the house air inlet draws in house air;
a heat exchanger connected to the single outside intake air inlet and the house air inlet, the heat exchanger transferring heat from the house air to the intake air;
a house air outlet, wherein the house air outlet prevents rain, animals, other living animals, and other environmental factors from entering the house air outlet, wherein the house air outlet releases the house air outside the house;
an intake air outlet connected to the heat exchanger, the intake air outlet releasing the intake air into the house;
an intake air outlet connected to the heat exchanger, the intake air outlet releasing the intake air into the house, wherein the intake air outlet directs the intake air away from the house air inlet;
a filter assembly adjacent the house air inlet, the filter assembly configured to receive a filter sized to filter out dust, debris, and other particulates;
the filter placed adjacent the filter assembly, the filter configured to filter the house air before the house air reaches the heat exchanger; and
a hanging inlet support that attaches to the house air inlet, the hanging inlet support suspending the house air inlet.

US Pat. No. 10,212,913

TEAT CUP CLEANING UNIT COMPRISING A DISTRIBUTION UNIT

1. A teat cup cleaning distribution unit for cleaning a plurality of teat cups, the teat cup cleaning distribution unit comprising:a housing defining:
a calming chamber having a calming chamber inlet, a calming chamber outlet, and an oblique wall that at least partially defines a calming chamber cross section that is at least partially tapered along a longitudinal axis from a larger cross section at the calming chamber inlet toward a smaller cross section at the calming chamber outlet, and the calming chamber inlet and the calming chamber outlet are substantially perpendicular to the longitudinal axis; and
a distribution chamber in communication with the calming chamber outlet and with a plurality of distribution chamber passages, and each distribution chamber passage is substantially identical in length and is in fluid communication with a respective distribution chamber outlet, and the calming chamber outlet is substantially perpendicular to each distribution chamber passage.

US Pat. No. 10,212,896

EMITTER, AND TUBE FOR DRIP IRRIGATION

ENPLAS CORPORATION, Sait...

1. An emitter for quantitatively discharging irrigation liquid in a tube from a discharge port communicating between an inside and an outside of the tube, the emitter being configured to be joined to an inner wall surface of the tube configured to distribute the irrigation liquid at a position corresponding to the discharge port, the emitter comprising:an emitter main body including a resin molded body including at least a recess and a through hole;
a film joined to at least one surface of the emitter main body, the film forming a channel by sealing at least a part of an opening of the recess and the through hole;
an intake part for receiving the irrigation liquid in the tube;
a liquid receiving amount regulating part for regulating a flow rate of the irrigation liquid received from the intake part;
a pressure reduction channel for allowing the irrigation liquid supplied from the liquid receiving amount regulating part to flow therethrough while reducing a pressure of the irrigation liquid;
a discharge rate regulating part for regulating the flow rate of the irrigation liquid supplied from the pressure reduction channel in accordance with a pressure of the irrigation liquid in the tube; and
a discharge part to which the irrigation liquid, having a flow rate regulated by the discharge rate regulating part, is supplied, the discharge part being configured to face the discharge port, wherein:
the liquid receiving amount regulating part includes:
a valve element which extends from a fixed end of a channel of the irrigation liquid in the emitter and opens to a downstream side when receiving a pressure of the irrigation liquid on an upstream side, and
a fixed part disposed at a position adjacent to the valve element in plan view,
each of the valve element and the fixed part has a shape of a circular sector in plan view,
wherein the shape of the circular sector is a portion of a disk enclosed by two radii and an arc, and
wherein the valve element and the fixed part are alternately disposed in a circumferential direction in plan view,
the valve element includes a thin part having flexibility and extending from the fixed end, and a thick part extending from the thin part,
the thin part bends and the valve element opens to the downstream side when a pressure of the irrigation liquid on an upstream side of the liquid receiving amount regulating part is equal to or higher than a predetermined value,
the emitter main body includes a part of the intake part, the liquid receiving amount regulating part, the pressure reduction channel, a part of the discharge rate regulating part, and the discharge part, and
the valve element and parts of the emitter main body other than the valve element are integrally molded with one material having flexibility.

US Pat. No. 10,212,895

CLEANING DEVICE

SMG Sportplatzmaschinenba...

1. A cleaning device comprising:a frame configured to drive over a ground surface;
a contact element;
a vibrating screen movably attached to the frame, the vibrating screen connected to the contact element;
at least one vibrating roller rotatably attached to the frame and rotatable about a rotary axis, the at least one vibrating roller having an outer surface with a plurality of radial elevations formed on the outer surface;
a pre-tensioning element configured to pre-tension the vibrating screen such that the contact element lies against the vibrating roller; and
at least one drive roller configured to rest on the ground surface, the drive roller coupled with the vibrating roller such that the drive roller causes the vibrating roller to rotate when the frame moves on the ground surface, wherein the vibrating roller is configured concentrically with the drive roller.

US Pat. No. 10,212,894

MODULAR VEGETATED ROOF SYSTEM

BIOROOF SYSTEMS INC., Bu...

1. A modular system for covering a surface with vegetation, the modular system comprising a plurality of modules, each of the modules comprising:(a) a drainage board having an upper surface for supporting a growth medium, the drainage board having a plurality of moisture receptacles extending downwardly from the upper surface for collecting moisture;
(b) a plurality of sidewalls having a multiplicity of apertures therethrough, each sidewall being coupled to the drainage board and extending upwardly therefrom, the sidewalls cooperating with each other so as to provide a perimeter for surrounding the growth medium; and
(c) a plurality of couplers for positively securing adjacent modules together, the couplers being located on the sidewalls above the drainage board; the couplers including
at least one female coupler located on a first sidewall of the plurality of sidewalls of each of the modules, the female coupler extending outwardly from the first sidewall; and
at least one male coupler located on a second sidewall of the plurality of sidewalls of each of the modules, the male coupler having a locking tab resiliently biased towards the second sidewall and configured to interlock with the female coupler of an adjacent one of the plurality of modules so as to positively secure the modules together.

US Pat. No. 10,212,893

TRUNK INJECTION NEEDLE

NANJING FORESTRY UNIVERSI...

1. A trunk injection needle, comprising: a front part which is conical, a middle part which is cylindrical, and a rear part which is cylindrical, which are respectively provided along a needle axis; wherein an outer diameter of the rear part is larger than outer diameters of the front part and the middle part; the front part has a bits guiding hole extending along the needle axis, and the rear part has a drug feeding hole extending along the needle axis; wherein the middle part has two outlet holes extending along a radial direction, and a separating board is provided between the two outlet holes; a rear end of the bits guiding hole communicates with the two outlet holes at two sides of the separating board; and a front end of the drug feeding hole communicates with the two outlet holes;wherein a blade part is provided at a front end of the separating board, which has a cutting edge; from the cutting edge backwards along the needle axis, a radial thickness of the blade part increases.

US Pat. No. 10,212,892

LIGHT SOURCES ADAPTED TO SPECTRAL SENSITIVITY OF PLANT

Once Innovatians, Inc., ...

1. A method of stimulating plant growth in a controlled environment steps comprising:providing a pair of input terminals that are adapted to receive a periodic excitation voltage such that the terminals receive a current of equal magnitude and opposite polarity, said current flowing in response to the excitation voltage to provide an AC input;
providing a lighting assembly that has driving circuitry that receives the AC input and conditions the current;
providing a network of lighting elements that produce light at a predetermined wavelength n response to the conditioned current;
positioning the lighting assembly adjacent a plant such that the light produced is received by the plant; and
modulating the conditioned current of the lighting elements with a control assembly to controllably provide predetermined periods of light and dark to stimulate continuous growth of the plant;
wherein the predetermined periods of light are in a range between 3.5 ms and 24 ms and the predetermined periods of dark are in a range between 3.5 ins and 24 ms.

US Pat. No. 10,212,891

GARDENING SHEAR

Jiin Haur Industrial Co. ...

1. A gardening shear comprising a first blade, a second blade, a first handle, and a second handle,wherein the first blade has a first cutting portion, and a first through hole and a second through hole respectively penetrate a middle portion and a lower portion of the first blade; the second through hole is located adjacent to one lateral side of the lower portion of the first blade, and a pivot portion laterally protruding from the other lateral side of the lower portion of the first blade has a third through hole thereon; the pivot portion and the first cutting portion are positioned at the same lateral side of the first blade;
wherein the second blade comprises a second cutting portion, and a fourth through hole penetrating through a middle portion of the second blade is located at a position corresponding to the first through hole of the first blade; when the first blade and the second blade are coupled together, the first through hole and the fourth through hole are adapted to be aligned to enable a first pivot member to pass therethrough so as to pivotally connect the first blade with the second blade; a protruding edge protruding from an edge of the middle portion of the second blade is located adjacent to the fourth through hole, and a fifth through hole penetrates through the protruding edge; a lower portion of the second blade has an arm, and a sixth through hole penetrating through the arm is located adjacent to a lower edge of the second blade;
wherein the first handle is a long pole, and an upper portion thereof has a first connecting section; a seventh through hole and a first elongated hole respectively penetrate through the first connecting section; the seventh through hole and the first elongated hole are configured to respectively be aligned with the second through hole of the first blade and the sixth through hole of the second blade, and a first connecting member is adapted to penetrate through the seventh through hole and the second through hole while a second pivot member is configured to penetrate through the first elongated hole and the sixth through hole to pivotally connect the first handle with the first blade and the second blade; a first rolling member is disposed on the second pivot member which penetrates through the first elongated hole, and the first rolling member is configured to roll and shift along the first elongated hole so as to enable the first handle to drive and open/close the first blade and the second blade; and
wherein the second handle is a long pole, and an upper portion thereof has a second connecting section; an eighth through hole and a second elongated hole respectively penetrate through the second connecting section; the eighth through hole and the second elongated hole are configured to be respectively aligned with the fifth through hole of the second blade and the third through hole of the first blade, and a second connecting member is adapted to penetrate through the eighth through hole and the fifth through hole while a third pivot member is configured to penetrate through the second elongated hole and the third through hole to pivotally connect the second handle with the first blade and the second blade; a second rolling member is disposed on the third pivot member which penetrates through the second elongated hole, and the second rolling member is configured to roll and shift along the second elongated hole so as to enable the second handle to drive and open/close the first blade and the second blade.

US Pat. No. 10,212,890

APPARATUS FOR CONVERTING LARGE BALES OF FORAGE MATERIAL INTO SMALL RECTANGULAR BALES OF FORAGE MATERIAL

Gerald E. Rohrer, Cochar...

1. A bale disintegration apparatus for disintegrating a large bale of forage or bedding material formed of individual compressed slices, comprising:a frame;
a feed conveyor to move large bales of forage or bedding material rearwardly;
an upwardly inclined conveyor for removing individual slices from said large bale delivered thereto by said feed conveyor and elevating said slices to an upper discharge end of said inclined conveyor;
a tumbler bed supported by said frame and having a plurality of tumbler shaft assemblies arranged in a horizontal array positioned rearwardly of said inclined conveyor to receive said slices elevated by said inclined conveyor, said tumbler bed being operable to disintegrate the elevated slices into discrete components of forage or bedding material that can fall downwardly through said tumbler bed, each said tumbler shaft assembly including a central shaft having mounted thereon a plurality of disks with each disk including at least one tooth projecting outwardly of the disk to engage said slices of forage or bedding material to affect disintegration thereof by removing discrete components thereof to pass between said disks;
a collecting conveyor operably supported by said frame below said tumbler bed to receive the discrete components of forage or bedding material falling from said tumbler bed, said collecting conveyor discharging said discrete components rearwardly for further processing; and
a drive mechanism for powering the operation of said inclined conveyor, said tumbler bed and said collecting conveyor.

US Pat. No. 10,212,889

BALER WITH AUTOMATED SELECTION OF EJECTOR TEETH

AGCO Corporation, Duluth...

1. A baling system operable to receive loose material, form the loose material into a bale, and eject the bale, the baling system comprising:a forming chamber having a discharge outlet, wherein the bale is located in the forming chamber;
a plurality of ejector teeth, with each of the plurality of ejector teeth being operable to selectively project into the forming chamber so as to engage a plurality of contents of the forming chamber and to selectively retract from the forming chamber so as to not engage the contents;
an ejector carriage operable to support the ejector teeth and to move parallel to the forming chamber from a back position in which the carriage is furthest from the discharge outlet to an eject position in which the carriage is closest to the discharge outlet;
a plurality of sensors positioned along an interior surface of the forming chamber, the plurality of sensors configured to identify a position of a face of the bale which is furthest from the discharge outlet; and
a control unit in communication with the sensors, the control unit configured to automatically select a subset of the plurality of ejector teeth based on the position of the face of the bale to project into the forming chamber so as to engage the bale while a remainder of the plurality of ejector teeth remain retracted from the forming chamber,
wherein during ejection of the bale from the forming chamber, the subset of the plurality of ejector teeth engage the bale, and the ejector carriage moves toward the discharge outlet such that the subset of the plurality of ejector teeth move the bale toward the discharge outlet while leaving any other of the contents of the forming chamber.

US Pat. No. 10,212,888

SIEVE ARRANGEMENT IN A CLEANING SYSTEM FOR A COMBINE HARVESTER

CNH Industrial America LL...

1. A sieve system of an agricultural vehicle for separating crop residue from grain, comprising:a frame;
a plurality of sieve sections pivotally coupled to the frame, the plurality of sieve sections including a first sieve section;
a plurality of dividers including a first divider coupled to the first sieve section; and
a pivoting system coupled to the first sieve section and the first divider, the pivoting system pivoting the sieve section at a first angle about a first axis, the pivoting system either pivoting the divider at a second angle about a second axis or flexing the divider at the second angle, the first angle being relative to the frame, the second angle being relative to the sieve section, the pivoting of the first sieve section at the first angle and the pivoting or flexing of the divider at the second angle are movements that are opposite each other, the first axis and the second axis being generally parallel to each other.

US Pat. No. 10,212,887

BALE MOVER WITH SELF-ADJUSTING SPINNERS

Harper Industries, Inc., ...

1. A bale-mover comprising:a base frame coupled to a vehicle;
a pair of bale-lifting arms disposed proximate opposite sides of the base frame, each arm in the pair being moveable to move at least a distal end of the arm toward the distal end of the other arm in the pair;
an axle disposed proximate the distal end of each arm and having a fixed orientation relative to the respective arm, each axle defining a respective axis of rotation;
a spinner body disposed along the length of each axle, each spinner body rotatable about the respective axis of rotation and pivotable relative to the respective axle; and
a coupler that couples the spinner body to the axle, the spinner body being rotatable relative to the respective axle about the respective axis of rotation and pivotable relative to the respective axle via the coupler.

US Pat. No. 10,212,886

RETRACTION MECHANISM FOR EXTENDABLE CARRIAGES OF AN AGRICULTURAL ACCUMULATOR

1. An accumulator coupled to an agricultural baler and configured to support crop packages exiting the agricultural baler, the accumulator comprising:a frame including a first end, a second end, and a support structure positioned between the first and the second ends;
a crop package moving assembly moveably coupled to the frame, the crop package moving assembly configured to move a first crop package in a first direction, the crop package moving assembly also configured to move a second crop package in a second direction opposite to the first direction;
a first carriage coupled to the first end of the frame and configured to move relative to the frame between a retracted position and an extended position, the first carriage configured to support the first crop package that exits the agricultural baler;
a second carriage coupled to the second end of the frame and configured to move relative to the frame between a retracted position and an extended position, the second carriage configured to support the second crop package that exits the agricultural baler;
a retraction linkage coupled to the crop package moving assembly and selectively engageable with the first and second carriages, the retraction linkage configured to move at least one of the first and second carriages from the extended position into the retracted position; and
a first extension linkage coupled between the frame and the first carriage and a second extension linkage coupled between the frame and the second carriage, wherein the first carriage is movable into the extended position in response to the first crop package engaging the first extension linkage, and wherein the second carriage is movable into the extended position in response to the second crop package engaging the second extension linkage.

US Pat. No. 10,212,885

FINGER ASSEMBLY FOR A FEED DRUM CONVEYOR OF AN AGRICULTURAL HARVESTING HEAD

1. A finger assembly for mounting on an offset shaft of a feed drum of an agricultural harvesting head comprises:a first finger support including a first ring portion and a second ring portion, wherein both ring portions are configured to be supported and retained on the offset shaft for rotation about the offset shaft, and a first finger mount portion fixed to the first ring portion and the second ring portion and configured to support and retain a first finger; and
a second finger support including a third ring portion, wherein the third ring portion is configured to be supported and retained on the offset shaft for rotation about the offset shaft, and second finger mount portion fixed to the third ring portion and configured to support and retain a second finger;
wherein the first ring portion and the second ring portion are fixed together and define a gap (“G”) into which the third ring portion is received and supported,
wherein the first ring portion comprises:
a first ring half;
a second ring half joined to the first ring half by a first hinge;
wherein the second ring portion comprises:
a third ring half;
a fourth ring half joined to the third ring half by a second hinge coaxial with the first hinge and spaced from the first hinge by the gap;
wherein the first finger mount portion comprises:
a first finger mount half connecting the first ring half and the third ring half; and
a second finger mount half connecting the second ring half and the third ring half, wherein the first finger mount half and the second finger mount half cooperate to form a first aperture therebetween for receiving a first finger,
wherein the third ring portion extends through the gap between the first hinge and the second hinge, the third ring portion comprising:
a fifth ring half;
a sixth ring half cooperating with the fifth ring half to form an aperture to receive the offset shaft, wherein the fifth ring half and the sixth ring half are not hinged together;
wherein the second finger mount portion comprises:
a third finger mount half extending from the fifth ring half;
a fourth finger mount half extending from the sixth ring half, wherein the third finger mount half and the fourth finger mount half cooperate to form a second aperture therebetween for receiving a second finger.

US Pat. No. 10,212,884

CUTTER BAR DRIVE FOR A MULTI-SECTION HEADER FOR ATTACHMENT TO HARVESTERS

1. A header for harvesting stalk crop, the header comprising:a frame;
a header bottom;
a multi-part cutter bar arranged at a front side of the frame relative to a travel direction of the header during harvesting, wherein the cutter bar comprises at least a first cutter bar part and a second cutter bar part arranged colinearly to each other and driven oscillatingly transverse to the travel direction;
cutter bar knives fastened to the first and second cutter bar parts;
stationary or moving counter knives connected to the frame and interact with the cutter bar knives;
a drive device operatively connected to the multi-part cutter bar;
conveying members configured to transport away cut stalk crop;
a gear housing arranged behind the first and second cutter bar parts;
the drive device comprising:
a first drive shaft ending in a first plane inside the gear housing;
an eccentric shaft that is stationarily supported in the gear housing;
a gear wheel fixedly connected to the eccentric shaft and arranged in a second plane above or below the first plane;
a bevel gear operatively connected to the gear wheel, wherein the first drive shaft is drivingly connected to the bevel gear and drives through the bevel gear the gear wheel;
a first eccentric disc connected to the eccentric shaft in the gear housing and arranged in a third plane;
a second eccentric disc connected to the eccentric shaft in the gear housing and arranged in a fourth plane above the third plane, wherein the first and second eccentric discs are mounted together on the eccentric shaft on top of each other;
a first eccentric lever correlated with the first eccentric disc and arranged in the third plane;
a second eccentric lever correlated with the second eccentric disc and arranged in the fourth plane;
a first pivot lever connected to the first eccentric lever and fixedly connected to a first stationarily supported pivot shaft;
a second pivot lever connected to the second eccentric lever and fixedly connected to a second stationarily supported pivot shaft;
a first crank arm fixedly connected to the first pivot shaft, wherein a pivot movement of the first crank arm is transmitted by a connecting element to the first cutter bar part;
a second crank arm fixedly connected to the second pivot shaft, wherein a pivot movement of the second crank arm is transmitted by a connecting element to the second cutter bar part.

US Pat. No. 10,212,883

HARVESTER HAVING A MEASURING DEVICE FOR GRAIN NUMBER DETECTION

CLAAS Selbstfahrende Ernt...

1. A harvester comprising:a measuring device comprising:
a sensor comprising an impact surface and a sound converter configured to produce a measuring signal associated with kernels impacting on the impact surface; and
a processing unit configured to:
process the measuring signal,
detect rising edges of the processed measuring signal without comparing the processed measuring signal with a reference signal, and
provide a grain number measurement based on the detected rising edges.

US Pat. No. 10,212,882

APPARATUS FOR CHOPPING AND DISCHARGING STRAW FROM A COMBINE HARVESTER

1. A chopper and discharge apparatus arranged to be mounted at the rear discharge of a combine harvester for receiving and discharging materials from the combine harvester comprising straw and/or chaff, the apparatus comprising:a housing having a feed opening into which a stream of said materials comprising straw and/or chaff is fed from the combine harvester;
a chopping assembly mounted in the housing for chopping said stream to form chopped materials;
the housing having a discharge opening through which the chopped materials are discharged;
a tailboard construction arranged relative to the housing so as to receive the stream of crop materials from the discharge opening to engage onto a downwardly facing guide surface of the tailboard construction for spreading of the crop materials;
a plurality of guide fins extending downwardly from the guide surface, the guide fins having a leading edge and fin surfaces extending from the leading edge rearwardly and outwardly from the leading edge to guide at least some of the chopped materials to sides of the tailboard construction in a spread pattern;
and a rotary spreader for spreading the crop material, the rotary spreader comprising rotating fan members each having a plurality of fan blades around an axis of the fan member so that the crop material enters the fan members and is carried around the axis by the fan members for discharge;
the rotary spreader being mounted for movement thereof relative to the housing to a first position in which the rotary spreader is spaced from the discharge opening of the housing so that in a first mode the crop material is spread wholly by the tailboard construction;
and the rotary spreader being mounted for movement thereof relative to the housing to a second position in which the rotary spreader is located with the fan blades adjacent the guide fins for cooperation therewith so that in a second mode the crop material is spread mainly by the rotary spreader.

US Pat. No. 10,212,881

MODIFICATION TO THE GRAIN HARVESTING COMBINE

Steven Lee Norburg, Alba...

1. A grain harvesting and threshing combine machine comprising:a threshing unit;
at least one sieve positioned directly below the threshing unit;
a tailings elevator;
a cleaning fan;
a grain tank positioned directly below the at least one sieve; and
a deflector plate covering an open portion of the grain tank;
wherein the at least one sieve substantially covers a remaining open portion of the grain tank; the tailings elevator conveys tailings from the at least one sieve back to the threshing unit; and the cleaning fan blows air across the at least one sieve, upward and towards the back of the machine thereby further removing chaff from the grain.

US Pat. No. 10,212,880

HIGH-EFFICIENCY CUTTING SYSTEM

MTD PRODUCTS INC, Valley...

1. A cutting system for an autonomous mower comprising:a housing having an outer circumference including at least one vertical standoff, and an open lower portion;
at least one rotating blade disk, provided within the housing and having a central portion, a top side, a bottom side, and a peripheral edge;
a first pair of cutting blades pivotably secured to the bottom side of the blade disk between the central portion of the blade disk and the blade disk peripheral edge, and extending away from the blade disk at an angle; and
a second pair of cutting blades pivotably secured to the bottom side of the blade disk radially inward and offset from the first pair of cutting blades, and extending away from the blade disk at an angle.

US Pat. No. 10,212,879

AUTOMATED MANURE AGITATION AND TRANSFER

Nuhn Industries Ltd., Se...

1. A system for automatically transferring liquid manure from an intermediate holding receptacle to a lagoon, comprisinga pump at least partially immersible in the liquid manure in an intermediate holding receptacle, the receptacle having a full receptacle sensor, the pump comprising a directable agitation nozzle, a pump motor configured to move the liquid manure from the receptacle into the pump, a first valve configured to control liquid flow out of the pump into the lagoon and a second valve configured to control liquid flow out of the pump through the directable agitation nozzle into the receptacle,
the pump in electronic communication with an electronic controller configured to control the pump motor, first valve, second valve and directable nozzle, the electronic controller comprising pre-programmed instructions to:
switch on the pump motor, ensure that the first valve is closed and ensure that the second valve is open in response to the electronic controller receiving a signal from the full receptacle sensor indicating that the liquid manure in the receptacle is at or exceeds a high level mark;
direct the nozzle to at least two different locations in the receptacle to permit liquid manure pumped from the receptacle by the pump to be redirected to the at least two different locations in the receptacle to agitate the liquid manure in the receptacle for a predetermined period of time; and,
open the first valve after the predetermined period of time to permit the pump to pump the liquid manure from the receptacle out to the lagoon.

US Pat. No. 10,212,878

AGRICULTURAL SEEDER IMPLEMENTS

1. An agricultural implement, comprising:an opener for cutting a furrow;
a frame mounted to the opener;
a first disk and a second disk each mounted to the frame;
the frame is mounted pivotally to the opener for movement between a first position and a second position;
the first disk and the second disk are each in a lowered position, when the frame is in the first position;
the first disk and the second disk are each in a raised position, when the frame is in the second position;
an element carried by the frame;
a first complemental element and a second complemental element carried by the opener;
the frame is disabled from moving beyond the first position thereof disabling the first disk and the second disk from moving beyond the lowered positions thereof, when the element is engaged to the first complemental element when the frame is in the first position thereof;
the frame is disabled from moving beyond the second position thereof disabling the first disk and the second disk from moving beyond the raised positions thereof, when the element is engaged to the second complemental element when the frame is in the second position thereof;
the element extends through a slot in the opener;
the slot is elongate and extends from a first end wall to a second end wall;
the element travels through the slot between the first end wall and the second end wall when the frame pivots between the first and second positions thereof;
the first end wall comprises the first complemental element; and
the second end wall comprises the second complemental element.

US Pat. No. 10,212,877

SEED TREATMENT FACILITIES, METHODS, AND APPARATUS

BAYER CROPSCIENCE LP, Re...

1. A method of treating seeds comprising:(A) selecting a seed treatment recipe;
(B) applying a plurality of seed treatment components to a batch of seeds via a seed treatment system;
wherein said seed treatment system comprises:
(i) a seed-treater vessel configured to apply the plurality of seed treatment components to the batch of seeds;
(ii) a plurality of pump-stations, wherein each pump station is configured to receive a keg, and each pump-station comprising a pump and a station controller configured to control the pump;
(iii) a plurality of kegs, each keg comprising:
(a) a seed treatment component; and
(b) a scale positioned underneath each keg;
(iv) at least one flex-tank coupled to a flex-tank pump and a pump controller configured to operate the flex-tank pump, and a scale positioned underneath the at least one flex-tank; and
(C) wherein the plurality of kegs and the at least one flex-tank deliver seed treatment components to the seed treater vessel and batch of seed based on the selected seed treatment recipe.

US Pat. No. 10,212,876

AERIAL DEPLOYMENT PLANTING METHODS AND SYSTEMS

DRONESEED CO., Seattle, ...

1. An aerial deployment planting system comprising:a first propagule capsule configured to contain one or more propagules and to be supported by an unmanned vehicle, said first propagule capsule comprising:
one or more absorbent below-ground-moisture collectors including a first absorbent below-ground-moisture collector;
one or more artificial moisture-transfer conduits; and
a first substrate configured to support said one or more artificial moisture-transfer conduits adjacent said one or more propagules and to allow below-ground seepage from said one or more absorbent below-ground-moisture collectors that extend more than 0.2 millimeters (mm) below a ground surface to flow by wicking via said one or more artificial moisture-transfer conduits to said one or more propagules, wherein a dry weight majority of at least one of said one or more artificial moisture-transfer conduits is dehydrated compressed peat or another growing medium configured to undergo a volumetric expansion of more than 20% when hydrated, wherein an exterior surface of said first propagule capsule includes a soil-contacting portion of said first absorbent below-ground-moisture collector larger than 1 square centimeter and configured to absorb more than 5 microliters of liquid per hour directly from surrounding soil by wicking, wherein an endmost portion longer than 0.5 mm of said first propagule capsule has a footprint of about 2 square mm, wherein said first propagule capsule is less than 5% water by weight, and wherein said one or more propagules comprise a dormant seed of a tree.

US Pat. No. 10,212,875

FARM VEHICLE

TOUTI TERRE, Rumilly (FR...

1. An apparatus comprising a traveling farm vehicle, said farm vehicle comprising a seat, a base, and a slide-way, wherein said seat is convertible between a sitting position and a kneeling position, said kneeling position being a working position, wherein said seat comprises a first cushion, a second cushion, a third cushion, wherein said first cushion supports a user's chest and head, wherein said second cushion supports a user's knees when said seat is in said kneeling position, and wherein said third cushion is a central cushion that pivots transversely between a lowered position and a raised position, wherein in said lower position, said third cushion supports said user's pelvis in said kneeling position, and wherein, in said raised position, said third cushion forms a sitting part in a sitting position, wherein said slide-way comprises a supporting slide-way, wherein said slide-way allows translation of said seat in a direction of travel, wherein said direction of travel is selected from the group consisting of travel along any combination of a first direction and a second direction transverse to said first direction, said first direction being a direction of travel of said vehicle, wherein said seat is mounted on said base, wherein said base is mounted to pivot on said slide-way to allow said first, second, and third cushions to pivot about a vertical pivot axis of said farm vehicle.

US Pat. No. 10,212,874

CURVED WAYLINE EXTENSIONS FOR CONTOUR PATH PLANNING

AGCO Corporation, Duluth...

1. A system, comprising:a mobile machine comprising a position determining device and an auto-steer subsystem; and
a processor configured to execute software to:
receive input corresponding to a contour wayline having a starting point and an ending point, the contour wayline describing a curved path,
analyze a plurality of data points of the contour wayline,
based on the analysis, generate a description of a curve corresponding to the plurality of data points,
based on the description of the curve, provide curved extensions of the contour wayline for auto-guidance, and
cause autonomous traversal of the mobile machine along a field according to the contour wayline and the extensions and corresponding projections.

US Pat. No. 10,212,873

HYBRID TILLAGE IMPLEMENT FOR VERTICAL TILLAGE AND AERATION OF SOIL WITH DEPOSIT OF SOIL ADDITIVE

CNH Industrial Canada, Lt...

1. An agricultural tillage implement, comprising:a frame including a pull hitch extending in a travel direction over the ground;
a vertical tillage section carried by said frame and extending generally laterally with respect to the travel direction, said vertical tillage system forming substantially continuous slits in ground being tilled;
an aerating section carried by said frame behind said vertical tillage section in the travel direction, said aerating section extending generally laterally with respect to the travel direction, and the aerating section including individual rotary tines to create discrete holes in ground being tilled as the agricultural implement moves in the travel direction; and
a ground deposit system connected to said frame and including a supply for a component to be deposited in the ground, a distribution network connected to said supply for distributing the component within the agricultural tillage implement, and outlets from the distribution network for expelling the component to the ground.

US Pat. No. 10,212,872

TURF AERATOR HAVING REMOVABLE COVER OVER ROTATABLE TINES

Turfco Manufacturing, Inc...

1. Turf aerator comprising, in combination:a chassis including first and second side plates, front and back plates extending between the first and second side plates, and a top plate extending between the first and second side plates and between the front and back plates, with the chassis being movably supported on turf adjacent to the front plate of the chassis;
a handlebar extending from the chassis in a direction away from the front plate;
a motor mounted on the top plate adjacent to the front plate;
a tine assembly rotatably mounted about an axis to the chassis between the first and second side plates and adjacent to the back plate, with the tine assembly being driven by the motor, with the tine assembly including a tine plate including a periphery rotatable about the axis and a plurality of tines, with each tine comprising a single component immovably fixed to the tine plate and extending from the axis in a radial direction for a radial extent to a free end configured to engage the turf;
an opening formed in the top plate intermediate the first and second side plates, intermediate the front and back walls, intermediate the motor and the back plate, and extending over the tine assembly, wherein the free ends of the plurality of tines extend through the opening formed in the top plate, and wherein the top plate is spaced from the axis less than the radial extent; and
a tine cover removably secured to the chassis, positioned over the free ends of the plurality of tines of the tine assembly above the axis, and closing the opening in the top plate.

US Pat. No. 10,212,871

ROW DIGGER

1. A Row Digger comprising:a main frame having a wheel connected to the main frame and a means for connecting the main frame to a vehicle opposite the wheel;
a hub frame connected to the main frame between the wheel and the means for connecting the main frame to a vehicle;
a hub assembly connected to the hub frame at a hub angle and having a hub housing and a hub flange with a plurality of hub tabs extending from the hub flange and wherein the hub flange can rotate with respect to the hub housing;
a plurality of digger arms corresponding in number to the plurality of hub tabs and connected to and extending from the plurality of hub tabs;
a plurality of digging discs corresponding in number to and connected to the plurality of digger arms;
a plurality of row digger stabilizers corresponding in number to and connected to the plurality of digger arms wherein the plurality of row digger stabilizers ensures proper placement of the plurality of digging discs such that the position of at least one of the plurality of digging discs is centered in a corresponding furrow in a field during use of the Row Digger in order to remove a dirt pile in the furrow; and
wherein the plurality of row digger stabilizers each has a stabilizer drum rotatably connected within a drum frame.
US Pat. No. 10,213,504

IMMUNOGENIC COMPOSITION FOR MODULATING THE IMMUNE SYSTEM AND METHODS TO TREAT BACTERIAL INFECTIONS IN A SUBJECT

1. A pharmaceutical product comprising one or more antibiotics and one or more immunological response shifter (IRS) immunogenic compositions for modulating the immune system comprising a therapeutically effective amount of three or more synthetic antigenic agents or natural antigenic agents, or fractions and combinations thereof, comprising pathogen-associated molecular patterns (PAMPS) and/or danger associated molecular patterns (DAMPS) selected from at least two groups consisting of: (A) antigenic agents with molecular patterns associated with bacteria, (B) antigenic agents with molecular patterns associated with viruses, (C) antigenic agents with molecular patterns associated with fungi and yeasts, (D) antigenic agents with molecular patterns associated with protozoa, (E) antigenic agents with molecular patterns associated with helminths, and (F) antigenic agents with molecular patterns associated with prions; and one or more physiologically acceptable carriers, excipients, diluents or solvents.
US Pat. No. 10,214,784

GENETIC MARKERS ASSOCIATED WITH INCREASED FERTILITY IN MAIZE

Syngenta Participations A...

1. A method for producing a Vip3A-expressing maize plant having increased male fertility compared to a Vip3A-expressing maize plant that has reduced male fertility or is male infertile, comprising:a) providing a first Vip3A-expressing maize plant comprising a quantitative trait locus (QTL) associated with increased male fertility in Vip3A-expressing maize plants, wherein the QTL is located on chromosome 5 and is flanked by and includes marker 7 (SEQ ID NO:561) and marker 8 (SEQ ID NO:566), and further comprises a haplotype that comprises i. an A polymorphism at marker 7; and ii. a G polymorphism at marker 8;
b) introgressing the QTL of a) into a second maize plant; and
c) selecting a Vip3-expressing maize plant comprising the QTL, thereby producing a Vip3A-expressing maize plant with increased male fertility compared to a Vip3A-expressing maize plant without the QTL.
US Pat. No. 10,213,505

ANTI-TIGIT ANIBODIES, ANTI-PVRIG ANTIBODIES AND COMBINATIONS THEREOF

Compugen Ltd., Holon (IL...

1. A composition comprising an anti-PVRIG antibody, wherein said antibody comprises:i) a heavy chain comprising SEQ ID NO:9, and
ii) a light chain comprising SEQ ID NO:14.
US Pat. No. 10,213,761

COATING PROCESS FOR MICROFLUIDIC SAMPLE ARRAYS

Life Technologies Corpora...

1. A method for differentially coating a substrate, the method comprising:supplying a substrate comprising an external surface and a plurality of through-hole channels each comprising an interior surface in communication with the exterior surface;
applying a first coating agent simultaneously to both the exterior surface and to at least one of the interior surfaces;
selectively oxidizing the at least one interior surface with an oxidizing agent;
after selectively oxidizing, selectively modifying the first coating agent applied to the at least one interior surface with a first modifying agent such that, after modifying, the at least one interior surface has a first specified physicochemical property that differs with respect to a specified physicochemical property of the external surface; and
applying a second modifying agent to the at least one interior surface;
wherein at least one of (1) the first coating agent comprises a vinyl terminated compound or (2) the first and second modifying agents each comprise a polyethylene glycol.
US Pat. No. 10,214,785

ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF

The Regents of the Univer...

1. A recombinant adeno-associated virus (rAAV) virion comprising:a) a variant AAV capsid protein, wherein the variant AAV capsid protein comprises a peptide insertion relative to a corresponding parental AAV capsid protein, wherein the peptide insertion comprises the amino acid sequence LGETTRP (SEQ ID NO:13), and wherein the insertion site is located between two adjacent amino acids at a position between amino acids corresponding to amino acids 570 and 611 of VP1 of AAV2 or the corresponding position in the capsid protein of another AAV serotype; and
b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.
US Pat. No. 10,214,786

WASTEWATER TREATMENT FOR THE PRODUCTION OF MICROBIAL BIOMASS

PROCELL INVESTMENTS LIMIT...

1. A method for growing microbial biomass comprising:(a) providing a wastewater stream;
(b) determining the concentration of micronutrients selected from the group consisting of aluminum, boron, cobalt, magnesium, manganese, and zinc, and any combination thereof, in the wastewater stream;
(c) determining the biological oxygen demand (BOD) normalized dose of the micronutrients;
(d) modulating the concentration of at least one micronutrient in the wastewater stream to provide a micronutrient-modulated wastewater stream, whereby said micronutrient-modulated wastewater stream has (i) a BOD normalized dose of aluminum between about 60 mg/day/lb BOD/day and about 285 mg/day/lb BOD/day; (ii) a BOD normalized dose of boron between about 115 mg/day/lb BOD/day and about 300 mg/day/lb BOD/day; (iii) a BOD normalized dose of cobalt between about 50 mg/day/lb BOD/day and about 500 mg/day/lb BOD/day; (iv) a BOD normalized dose of magnesium of at least about 100 mg/day/lb BOD/day; (v) a BOD normalized dose of manganese between about 65 mg/day/lb BOD/day and about 220 mg/day/lb BOD/day; and (vi) a BOD normalized dose of zinc between about 115 mg/day/lb BOD/day and about 275 mg/day/lb BOD/day; and
(e) growing microbial biomass in the micronutrient-modulated wastewater stream.
US Pat. No. 10,213,507

COMPOSITIONS AND METHODS FOR TREATING HIV-ASSOCIATED NEUROCOGNITIVE DISORDERS

THE FLORIDA INTERNATIONAL...

1. A formulation comprising magnetic nanoparticles (MENPs) conjugated to or mixed with a therapeutic cargo, the therapeutic cargo comprising withaferin A (WA), miR-107 or an expression vector encoding miR-107, and BD1063, at least a portion of the MENPs surface being coated with one or more of glycerol monooleate, poly L-lysine and polyethylene glycol, the MENPs being encapsulated within liposomes; WA being in a hydrophobic part of the liposome, miR-107 or an expression vector encoding miR-107 bound to the MENPs based on electrostatic interaction, and BD1063 being in a hydrophilic part of the liposome.
US Pat. No. 10,213,763

PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE

IMMUNOLIGHT, LLC., Detro...

1. A system for producing a change in a medium to be treated, comprising:an energy source capable of producing an initiation energy comprising one or more of x-rays, gamma rays, or an electron beam;
a container holding the medium to be treated;
an energy modulation agent surrounded by an encapsulation, disposed inside or in a vicinity of the medium to be treated, and separated physically from the medium to be treated by the encapsulation;
a plasmonics agent in a vicinity of the medium; and
said energy modulation agent comprising a photon emitter which emits at least one of ultraviolet and visible light upon interaction with said initiation energy, wherein said at least one of ultraviolet and visible light stimulates a chemical or biological process in the medium.
US Pat. No. 10,214,788

COMPOSITE IRON PELLETS

SAUDI BASIC INDUSTRIES CO...

1. A composite iron pellet having a core and shell structure,the pellet comprising:
(a) an inner core comprising:
i. iron ore; and
ii. a reducing agent comprising a carbonaceous material;
(b) an outer shell comprising unreduced iron ore;
wherein the composite iron pellet comprises at least 90 wt % Fe2O3, and wherein the inner core comprises from 88.0 wt % to 97 wt % Fe2O3 and from 3 wt % to 9.5 wt % of said carbonaceous material; wherein the pellets are fired.
US Pat. No. 10,213,509

REDUCED FOAMING VACCINE COMPOSITIONS

MERIAL INC., Duluth, GA ...

1. A process for reducing the foaming of a solid vaccine composition when mixed with a liquid diluent, comprising adding an effective amount of a foam controlling agent to a solid composition susceptible to foaming comprising at least one anhydrous antigenic component, a stabilizer and an effervescent agent, whereby the solid vaccine composition is produced;wherein the foam controlling agent is a sugar alcohol, and the effective amount of sugar alcohol is about 15% to 40% by weight of the solid vaccine composition, and upon adding a diluent to the solid vaccine composition, the effervescent agent reacts to form gas in situ, and foam resulting from the gas is reduced.
US Pat. No. 10,213,765

CHROMATOGRAPHY LIGAND COMPRISING DOMAIN C FROM STAPHYLOCOCCUS AUREUS PROTEIN A FOR ANTIBODY ISOLATION

1. A chromatography matrix comprising:a solid support; and
a ligand coupled to the solid support, the ligand comprising at least two polypeptides,
wherein the amino acid sequence of each polypeptide comprises at least 55 contiguous amino acids of a modified SEQ ID NO. 1, and
wherein the modified SEQ ID NO. 1 has an alanine (A) instead of glycine (G) at a position corresponding to position 29 of SEQ ID NO. 1.
US Pat. No. 10,213,511

THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS

Frequency Therapeutics, I...

1. A poloxamer containing pharmaceutical composition having a gelation temperature greater than 10° C., the composition comprising:a) a 2,4-dichlorophenyl-5-(1H-imidazol-2-yl)-2-pyrimidinylaminoethylamino-2-pyridine compound;
b) Poloxamer 407 at greater than or equal to 21 wt % of the pharmaceutical composition; and
c) a carboxylic acid containing compound;wherein the pharmaceutical composition has a gelation temperature of greater than 10° C.
US Pat. No. 10,213,512

TOPICAL TETRACYCLINE COMPOSITIONS

FOAMIX PHARMACEUTICALS LT...

32. A method of treating or alleviating the symptoms of a dermatological, ophthalmological, gynecological, or mucosal disorder, comprising applying to a patient in need thereof the foam of claim 1.
US Pat. No. 10,213,768

NOX TRAP

Johnson Matthey Public Li...

1. A NOx trap catalyst comprising a substrate, a first layer, and a second layer; wherein the first layer comprises a NOx trap composition comprising one or more noble metals, a NOx storage component, a first support material, and a first ceria-containing material, wherein the first ceria-containing material is pre-aged prior to incorporation into the first layer; and the second layer comprises rhodium, a second ceria-containing material, and a second support material, wherein the second ceria-containing material is not pre-aged prior to incorporation into the second layer.
US Pat. No. 10,214,792

PROCESS FOR MANUFACTURING STEEL SHEET

ArcelorMittal France, Sa...

1. A process for manufacturing a hot-rolled steel sheet having a tensile strength greater than 800 MPa and an elongation at break greater than 10% comprising the steps of:providing a steel with a composition that comprises, the contents being expressed by weight:
0.050%?C?0.090%;
1%?Mn?2%;
0.015%?Al?0.050%;
0.1%?Si?0.3%;
0.10%?Mo?0.40%;
S?0.010%;
P?0.025%;
0.003%?N?0.009%;
0.12%?V?0.22%;
Ti<0.005%; and
Nb?0.020%;the balance of the composition comprising iron and inevitable impurities resulting from smelting;casting a semi-finished product from the steel;
heating the semi-finished product to a temperature above 1150° C.;
hot rolling the semi-finished product to obtain a steel sheet at an end of rolling temperature TER in a temperature range so microstructure of the steel is entirely austenitic;
cooling the steel sheet at a cooling rate Vc from 75 to 200° C./s; and
coiling the steel sheet at a temperature Tcoil from 500 to 600° C.,
a microstructure of the steel sheet consisting of, as a surface fraction, at least 80% upper bainite, lower bainite, martensite and residual austenite, a sum of the martensite and residual austenite contents being less than 5%.
US Pat. No. 10,213,513

TREATING MYELOMAS

Mayo Foundation for Medic...

1. A method for treating a mammal having myeloma, said method comprising administering to said mammal an effective amount of a composition comprising nanoparticles containing albumin-bound paclitaxel complexed with an anti-CD38 polypeptide antibody, said complexed nanoparticles having an average diameter of less than 1 ?m, wherein the effective amount is an amount that treats the myeloma,wherein the effective amount for the anti-CD38 polypeptide antibody is about 5 mg/kg to about 20 mg/kg.
US Pat. No. 10,213,514

FUNCTIONALIZING NANOFIBRES

1. A functionalized nanofibre comprising an electrospun dispersion of a polymer in admixture with a water-soluble synthetic construct of the structure F-S-L where F is a functional moiety expressed or presented at the surface of the nanofibre, L is a lipid incorporated into the nanofiber and S is a spacer linking F to L via covalent bonds.
US Pat. No. 10,214,538

PROCESS FOR PREPARATION OF DARUNAVIR

Laurus Labs Ltd., Hydera...

1. A process for preparation of amorphous darunavir, comprising the steps of:a) providing a first solution comprising an acid and a solvent, at a temperature of about ?5° C. to about 10° C., wherein the acid is acetic acid and the solvent is either acetonitrile or water;
b) adding an amount of darunavir propionate solvate to the first solution to form a second solution;
c) combining the second solution of step b) with a base and water at a temperature of about ?10° C. to about 0° C., wherein the base is ammonia to form a third solution; and
c) recovering the amorphous darunavir from the third solution of step b), wherein the purity of the amorphous darunavir is equal to or greater than about 99.7% as measured by HPLC.
US Pat. No. 10,214,794

METHOD FOR MANUFACTURING COMPONENTS FOR GAS TURBINE ENGINES

General Electric Company,...

1. A method of manufacturing a component for a gas turbine engine, the method including the steps of:providing a forged preform of the component, the forged preform being made from a stainless steel alloy;
identifying two non-overlapping portions of the component that together form a whole of the component: a target portion and a remainder portion; and
treating the component with a regionally selective tempering process configured such that a treated region receives the regionally selective tempering process while an untreated region is prevented from receiving the regionally selective tempering process;
wherein:
the target portion comprises the treated region and the remainder portion comprises the untreated region of the regionally selective tempering process; and
the regionally selective tempering process is configured to appreciably increase a hardness of the target portion of the component relative to a hardness of the remainder portion of the component.
US Pat. No. 10,213,515

GLYCOPEPTIDE FOR CONTRAST AGENT TARGETING CANCER CELLS AND CONTRAST AGENT KIT CONTAINING THE SAME

KOREA INSTITUTE OF SCIENC...

1. A glycopeptide for a contrast agent targeting cancer cells, comprising:an azide reporting monosaccharide; and
a substrate peptide, wherein
the azide reporting monosaccharide and the substrate peptide are bound to form the glycopeptide,
the azide reporting monosaccharide is selected from N-azidoalkyl-D-mannosamine, N-azidoalkyl-D-galactosamine and N-azidoalkyl-D-glucosamine,
the substrate peptide has 4-30 amino acids and an amino acid sequence of SEQ ID NO: 1, and
the substrate peptide is specifically cleavable by cathepsin B in a cancer cell.
US Pat. No. 10,213,772

MIDDLE DISTILLATE HYDROCRACKING CATALYST CONTAINING ZEOLITE USY WITH ENHANCED ACID SITES

Chevron U.S.A. Inc., San...

1. A hydrocracking catalyst for making middle distillates comprising:a. greater than 10 wt % of a zeolite USY having:
i. a total OD acidity of 0.350 to 0.650 mmol/g;
ii. an ASDI between 0.05 and 0.15;
iii. a BET surface area greater than 600 m2/g;
iv. a SAR greater than 10;
v. less than 45 vol % of pores greater than 2 nm;
b. a support; and
c. at least one metal selected from the group consisting of elements from Group 6 and Groups 8 through 10 of the Periodic Table;wherein the OD acidity and the ASDI are determined by H/D exchange of acidic hydroxyl groups at equilibrium at 80° C. by FTIR spectroscopy.
US Pat. No. 10,216,076

CERAMIC COMPOSITE, PHOSPHOR FOR PROJECTOR INCLUDING THE SAME, AND LIGHT EMITTING DEVICE FOR PROJECTOR INCLUDING THE SAME

COORSTEK KK, Tokyo (JP)

1. A ceramic composite comprising inorganic materials and comprising: a phosphor phase comprising YAG containing Ce; and a scatterer phase comprising a translucent ceramic, wherein:the phosphor phase is contained in an amount of 90 vol % or more and 99 vol % or less; and
the scatterer phase is contained in an amount of 1 vol % or more and 10 vol % or less.
US Pat. No. 10,213,773

PROCESS FOR THE CONVERSION OF OXYGENATES TO OLEFINS

BASF SE, (DE)

1. A process for converting oxygenates to olefins, the process comprising:converting one or more C1-C4 alcohols or mixtures of two or more thereof to one or more ethers in a dehydrogenation reactor to provide a gas stream comprising the one or more ethers and water;
contacting a catalyst, which includes a support substrate and a catalytic layer applied to the substrate, the layer comprising one or more zeolites of the MFI, MEL, or MWW structure type or any one mixture thereof, with the gas stream and further comprising
calcining the catalyst only in air atmosphere to provide a regenerated catalyst,
providing the gas stream, and
contacting the regenerated catalyst with the gas stream wherein selectivity of C3 and C4 is increased after being subjected to the regeneration of the catalyst.
US Pat. No. 10,213,774

ZSM-5 CATALYST

BASF Corporation, Florha...

1. ZSM-5 zeolite microspheres formed by 1) shaping a mixture into microspheres wherein the mixture comprises a silica material and a plurality of particulates selected from the group consisting of at least one high-density material with an absolute bulk density of at least 0.3 g/cc, ZSM-5 zeolite crystals, and combinations thereof; 2) calcining the microspheres; and 3) reacting and subsequently heating the microspheres with at least one alkali solution to form ZSM-5 zeolite in-situ on the microspheres, wherein the ZSM-5 zeolite microspheres contain substantially no clay or calcined clay material.
US Pat. No. 10,214,799

HEAT TREATMENT METHOD FOR INCREASING THE DEPTH OF HARDENING LAYER IN A STEEL RAIL AND STEEL RAIL OBTAINED WITH THE METHOD

1. A heat treatment method for increasing the depth of hardening layer in a steel rail, the method comprising the following steps:a. natural cooling: cooling a finished rolling steel rail by natural cooling, till the temperature at the center of rail head surface drops to 660˜730° C.;
b. first accelerated cooling stage: cooling the steel rail cooled down in step a by accelerated cooling at 1.5˜3.5° C./s cooling rate, till the temperature at the center of rail head surface is 500˜550° C.;
c. second accelerated cooling stage: cooling the steel rail cooled down in step b by accelerated cooling at a cooling rate that is 1.0˜2.0° C./s higher than the cooling rate in the first accelerated cooling stage, till the temperature at the center of rail head surface is 450° C. or lower;
d. air cooling: stopping the accelerated cooling, and cooling down the steel rail by air cooling to room temperature,
and wherein the carbon content in the steel rail is 0.75%˜0.90%, the silicon content in the steel rail is 0.54%˜0.96%, the manganese content in the steel rail is 0.69%˜1.35%, the phosphorus content in the steel rail is 0.009%˜0.018%, the sulphur content in the steel rail is 0.006%˜0.012%, the chromium content in the steel rail is 0.03%˜0.58%, the vanadium content in the steel rail is 0˜0.07%, and the remaining content is ferrum.
US Pat. No. 10,214,800

HIGH DURABILITY STRUCTURES OF AMORPHOUS ALLOY AND A METHOD OF FORMING

Crucible Intellectual Pro...

1. An article comprising:an exterior surface consisting of a bulk-solidifying amorphous alloy having a yield strength of at least 2 GPa, the exterior surface including a loading surface and a back surface on an opposite side of the loading surface;
the loading surface subject to a bending force toward the back surface, the back surface thereby subject to tensile stress;
the back surface including a surface treatment comprising a shot peening process; and
the loading surface not including the surface treatment;
wherein the back surface has an enhanced durability as compared to the loading surface and wherein the treated article is a golf ball face insert.
US Pat. No. 10,213,521

USEFUL POLYSACCHARIDE AFTER RADIATION STERILIZATION

MEDTRONIC XOMED, INC., J...

1. A method comprising: (a) providing a polysaccharide, (b) removing at least a portion of impurities from a manufacturing process of the polysaccharide to obtain an integration ratio of 1 or less, wherein the integration ratio is capable of being evaluated using 1H NMR spectroscopy by comparing a first value of a peak between about ? 3.92 ppm and about ? 3.94 ppm with a second value of a reference peak at about ? 4.5 ppm, (c) drying the polysaccharide to a moisture content of 7% by weight or less, (d) packaging the polysaccharide in less than 2% oxygen, and (e) sterilizing the polysaccharide with ionizing radiation to provide a sterilized polysaccharide, wherein the sterilized polysaccharide is soluble and has an extended shelf life having less than a 50% change in solids content after nine months as measured using the Percent Solids Measurement.
US Pat. No. 10,215,825

MAGNETIC MICROSTRUCTURES FOR MAGNETIC RESONANCE IMAGING

The United States of Amer...

1. A magnetic resonance structure consisting of:(i) a pair of disks of a magnetic material aligned parallel to each other; and
(ii) a spacer material that holds the pair of disks apart from each other,
wherein the disks consist of a magnetic material selected from the group consisting of a ferromagnetic material, a paramagnetic material, a superparamagnetic material, a magnetic alloy, a magnetic compound, and a combination thereof, and
wherein the spacer material is flexible and non-magnetic and configured to adjust the distance between the pair of disks in response to a condition of an environment when the magnetic resonance structure is located in the environment, and wherein the spacer material consists of a photo-epoxy, a hydrogel, or one or more polymers.
US Pat. No. 10,216,081

PELLICLE FRAME, PELLICLE AND METHOD OF MANUFACTURING THE SAME, ORIGINAL PLATE FOR EXPOSURE AND METHOD OF MANUFACTURING THE SAME, EXPOSURE DEVICE, AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE

MITSUI CHEMICALS, INC., ...

1. A pellicle frame comprising a frame body, the frame body havinga groove formed in one end surface of the frame body, the one end surface being an end surface in a thickness direction of the frame body that is located at a side configured to support a pellicle membrane, and
a through-hole that penetrates through a portion between an outer circumferential surface of the frame body and a wall surface of the groove formed in the one end surface,
wherein the frame body does not have a through-hole that penetrates through a portion between an inner circumferential surface and the wall surface of the groove formed in the one end surface.
US Pat. No. 10,213,522

ULTRAPURE MAGNESIUM ALLOY WITH ADJUSTABLE DEGRADATION RATE

DePuy Synthes Products, I...

1. A medical implant comprising:a MgZnCa alloy containing nanosized precipitates, wherein the nanosized precipitates are less noble than a MgZn alloy, and wherein the MgZnCa alloy has a Zn content ranging from 3.0 wt. % Zn to 6 wt. % Zn and a calcium content ranging from 0.0005 wt. % Ca to 1.0 wt. % Ca, less than 0.001 wt. % of one or more other elements and with the remainder of the alloy being Mg, wherein the Mg has a purity of at least 99.997 wt. %.
US Pat. No. 10,216,084

SULFONIC ACID DERIVATIVE, PHOTOACID GENERATOR USING SAME, RESIST COMPOSITION, AND DEVICE MANUFACTURING METHOD

Toyo Gosei Co., Ltd., Ic...

4. A photoacid generator composing:a sulfonic acid derivative of the following general formula (1):
R1COOCH2CH2CFHCF2SO3?M+  (1)wherein:R1 represents a monovalent organic group having carbon number of 1 to 200, having at least one hydroxyl group and optionally having a substituent other than the hydroxyl group; and
M+ represents a counter cation.
US Pat. No. 10,213,525

USE OF PERFUSION DECELLULARIZED LIVER FOR ISLET CELL RECELLULARIZATION

Micromatrix Medical, Inc....

1. A method to prepare a graft comprising:providing a perfusion decellularized extracellular matrix of a mammalian liver, a portion of a liver, a liver lobe or a portion thereof that is >8 cm3, and two populations of cells, wherein the two populations of cells comprise a first population of mammalian cells comprising endothelial cells, stem cells capable of differentiation into endothelial cells, progenitor cells capable of differentiation into endothelial cells, or any combination thereof, and a second population of mammalian cells comprising insulin producing cells, stem cells capable of differentiation into insulin producing cells, progenitor cells capable of differentiation into insulin producing cells, or any combination thereof; and
contacting the perfusion decellularized extracellular matrix and the two populations of cells under conditions and for a period of time so that cells in the first population re-endothelialize a vasculature of the perfusion decellularized extracellular matrix and cells in the second population recellularize the perfusion decellularized extracellular matrix, wherein if the cells in the first population are stem cells or progenitor cells, the conditions allow for those cells to differentiate into endothelial cells, and wherein if the cells in the second population are stem cells or progenitor cells, the conditions allow for those cells to differentiate into insulin producing cells.
US Pat. No. 10,214,805

ENHANCED ACTIVATION OF SELF-PASSIVATING METALS

SWAGELOK COMPANY, Solon,...

1. A process for activating a workpiece for subsequent low temperature carburizing, nitrocarburizing or nitriding, the workpiece being made from a self passivating metal and having one or more surface regions which define a Beilby layer as a result of a previous metal shaping operation, the process comprising exposing the workpiece to contact with vapors produced by heating an oxygen-free nitrogen halide salt to a temperature which is high enough to convert the oxygen-free nitrogen halide salt to vapors, the workpiece being exposed to these vapors at an activating temperature which is below a temperature at which nitride and/or carbide precipitates form for a time sufficient to activate the workpiece.
US Pat. No. 10,213,526

METHODS FOR PREPARATION OF A TERMINALLY STERILIZED HYDROGEL DERIVED FROM EXTRACELLULAR MATRIX

University of Pittsburgh-...

1. A method of preparing an extracellular matrix-derived gel comprising, in order: (i) solubilizing extracellular matrix (ECM) that has not been dialyzed by digestion with an acid protease in an acidic solution to produce a digest solution, (ii) drying the digest solution, and (iii) terminally sterilizing the dried digest.
US Pat. No. 10,213,527

FUNCTIONALIZED TITANIUM BINDING PEPTIDES AND IMPLANTS COATED WITH SAME

Ben-Gurion University of ...

1. A method of generating or repairing a tissue, the method comprising implanting an article of manufacture selected from the group consisting of a dental impant, a hip prosthesis, a knee prosthesis, a heart valve, and an intravascular stent comprising a titanium surface and an isolated peptide adsorbed to said surface into a subject in need thereof, said isolated peptide comprising a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein:(i) said titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide;
(ii) said titanium oxide binding amino acid sequence is selected to induce a beta sheet structure;
(iii) said titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to said titanium oxide under physiological conditions; and
(iv) said titanium oxide binding amino acid sequence comprises the sequence Z-X-Z-X, wherein X is any hydrophobic amino acid and Z is phosphoserine or L-DOPA,
thereby generating or repairing the tissue.
US Pat. No. 10,213,528

DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES

Surmodics, Inc., Eden Pr...

1. A drug delivery coating comprisinga base polymeric layer, the base polymeric layer comprising a hydrophilic surface;
a therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising
a particulate hydrophobic therapeutic agent; and
a cationic block copolymer comprising charged blocks and uncharged blocks disposed over the particulate hydrophobic therapeutic agent;
wherein the cationic block copolymer forms an exterior surface of the drug delivery coating; and
wherein a charge provided by the cationic block copolymer confers to the therapeutic agent layer an electrostatic attraction to negative charges or polar groups of a lipid bilayer of a cellular membrane and cellular components after implantation of a device bearing the coating in a subject.
US Pat. No. 10,214,552

METHOD FOR PURIFYING BETA-NICOTINAMIDE MONONUCLEOTIDE

BONTAC BIO-ENGINEERING (S...

1. A method for preparative purification of a salt of ?-nicotinamide mononucleotide, comprising:a. sequentially microfiltrating and nanofiltrating a crude product solution containing ?-nicotinamide mononucleotide to obtain a concentrated crude product solution containing ?-nicotinamide mononucleotide;
b. adjusting the concentrated crude product solution to pH 3-7 to obtain a loading solution, loading the loading solution onto a preparative reverse phase high performance liquid chromatographic column, and purifying a salt of ?-nicotinamide mononucleotide by gradient elution with an octadecylsilane-bonded silica gel as a stationary phase, a hydrochloric acid solution at pH 3-7 as a mobile phase A, and 100% ethanol as a mobile phase B obtain a purified sample solution containing ?-nicotinamide mononucleotide; and
c. concentrating the purified sample solution by nanofiltrating the purified sample solution to obtain a concentrated purified sample solution, and freeze drying the concentrated purified sample solution in a vacuum freeze drier to obtain a purified salt of ?-nicotinamide mononucleotide.
US Pat. No. 10,216,088

PHOTOLITHOGRAPHY METHOD BASED ON ELECTRONIC BEAM

Tsinghua University, Bei...

1. A photolithography method, the method comprising:emitting an incident electron beam;
making the incident electron beam pass through a two-dimensional nanomaterial to form a transmission electron beam and a plurality of diffraction electron beams;
shielding the transmission electron beam; and
radiating a surface of an object by the plurality of diffraction electron beams.
US Pat. No. 10,213,529

DELIVERY OF COATED HYDROPHOBIC ACTIVE AGENT PARTICLES

SurModics, Inc., Eden Pr...

1. A drug delivery device comprising:a substrate;
a hydrophilic polymer layer disposed on the surface of the substrate; and
an active agent layer consisting of coated therapeutic agent particles disposed on the surface of the hydrophilic polymer layer to form the outside surface of the drug delivery device, wherein the coated therapeutic agent particles are comprised of:
a particulate hydrophobic therapeutic agent core, the particulate hydrophobic therapeutic agent core having an average diameter of between 100 nm and 10 ?m; and
a cationic agent coating disposed on the surface of the particulate hydrophobic therapeutic agent core and configured to be in direct contact with a lipid bilayer of a cell membrane.
US Pat. No. 10,213,785

METHOD AND DEVICE FOR POLYMERASE CHAIN REACTION

NATIONAL CHENG KUNG UNIVE...

1. A method for amplifying a nucleic acid sequence in a polymerase chain reaction (PCR), the method comprising:contacting, in a reaction vessel, a reaction mixture comprising the nucleic acid sequence and necessary reagents for the PCR with particles comprising a transition metal material; and
amplifying the nucleic acid sequence by increasing a temperature of the reaction mixture by irradiating the particles with electromagnetic radiation (EMR) having a frequency of about 300 THz to 400 THz and decreasing the temperature of the reaction mixture,
wherein the transition metal material is Fe3O4 and does not include an Au coating.
US Pat. No. 10,213,530

POLYMER FILM AND ANTIADHESIVE MATERIAL USING THE SAME

Toray Industries, Inc., ...

1. A polymer film comprising a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, whereinthe branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule,
mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%,
a value obtained by dividing average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000, and
the polymer film is two dimensional and has a film thickness of 80 to 400 nm.
US Pat. No. 10,216,090

PATTERN-FORMING METHOD AND COMPOSITION FOR RESIST PATTERN-REFINEMENT

JSR CORPORATION, Tokyo (...

14. A pattern-forming method comprising:forming a prepattern that is insoluble or that has a low solubility such that a shape of the prepattern is substantially maintained in an organic solvent;
bringing into contact with at least lateral faces of the prepattern, a composition which comprises a basic compound and an organic solvent and which does not comprise a polymer having a solubility in an organic solvent to be decreased by an action of an acid;
applying a composition on at least lateral faces of the prepattern to form a resin layer, the composition comprising a polymer having a solubility in the organic solvent to be decreased by an action of an acid, the polymer having a weight average molecular weight of no less than 13,000 and no greater than 150,000;
insolubilizing or desolubilizing in the organic solvent, regions adjacent to and in contact with the prepattern of the resin layer without being accompanied by an increase in a molecular weight by heating the prepattern and the resin layer; and
removing regions other than the regions insolubilized or desolubilized of the resin layer with the organic solvent.
US Pat. No. 10,213,531

COATING OF A VASCULAR ENDOPROSTHESIS

AACHEN SCIENTIFIC INTERNA...

1. A method for coating a vascular endoprosthesis, comprising the following steps:a1) at least partial wetting of the vascular endoprosthesis with a first solution of an active ingredient, and
b) at least partial wetting of the areas of the vascular endoprosthesis wetted with the first solution solution of the active ingredient with a liquid containing one or more of a water and at least one of an alcohol and a ketone.
US Pat. No. 10,214,811

VAPOR DEPOSITION PROCESS FOR THE MANUFACTURE OF COATED PARTICLES

PneumatiCoat Technologies...

1. An atomic or molecular layer deposition process for coating the interior pores and exterior surfaces of a substrate, comprising:(a) placing a substrate comprising pores into a substrate reservoir through a first valve, wherein said substrate reservoir is operatively connected to, and initially isolated from, a first precursor reservoir, by a second valve;
(b) closing said first valve;
(c) producing a first reactive precursor vapor in said first precursor reservoir under pressure conditions sufficient to:
i. cause the first reactive precursor vapor to flow into the substrate reservoir upon opening the second valve;
ii. adequately saturate the surface area of the substrate with the first reactive precursor;
iii. deposit a layer of the first reactive precursor on the interior pores and exterior surfaces of said substrate;
(d) opening said second valve and allowing the pressure in the combined volumes of the substrate reservoir and the first precursor reservoir to equilibrate;
(e) conveying the substrate from the substrate reservoir into the first precursor reservoir, thereby producing a first reactive precursor coated substrate;
(f) removing excess first reactive precursor and gaseous reaction byproducts; and
(f) contacting the first reactive precursor coated substrate with a second reactive precursor vapor under conditions sufficient to produce an atomic or molecular layer deposition coated substrate semi-continuously.
US Pat. No. 10,214,556

METHOD FOR PURIFYING REDUCED FORM OF ?-NICOTINAMIDE ADENINE DINUCLEOTIDE

BONTAC BIO-ENGINEERING (S...

1. A method for purifying a salt of the reduced form of ?-nicotinamide adenine dinucleotide (NADH), comprising:a. sequentially microfiltrating and nanofiltrating a crude solution containing NADH and NAD+ to obtain a concentrate containing NADH and NAD+;
b. adding an ion pair reagent to the concentrate to obtain a loading sample, loading the loading sample onto a reverse-phase chromatographic column, and eluting the reverse chromatographic column with a gradient of a buffer solution as a phase A and ethanol as a phase B to obtain a purified NADH solution;
c. changing cations in the purified NADH solution to sodium ions by a cation exchange resin to obtain a product solution; and
d. nanofiltrating the product solution to obtain a concentrated product solution, and freeze drying the concentrated product solution in a vacuum freeze drier,
wherein the ion pair reagent in step b is a tetramethylammonium hydroxide solution, the buffer solution in step b is a 20 mM buffer solution formulated with hydrochloric acid and aqueous ammonia at pH 7-9, and the ethanol is anhydrous ethanol.
US Pat. No. 10,214,559

PROTEIN RECOVERY

Heriot-Watt University, ...

1. A process for the recovery of proteinaceous matter, from a by-product stream arising from distillation processes, the process comprising:optionally, lysing or disrupting cells present in the by-product stream;
removing solid matter from the by-product stream to yield a clarified proteinaceous matter containing solution;
contacting the clarified proteinaceous matter containing solution with an adsorption matrix under conditions such that the proteinaceous matter binds to the matrix; wherein the adsorption matrix comprises a silica content of greater than 50% wt; and
altering the conditions to cause release of all of or a specific fraction of the proteinaceous matter bound to the adsorption matrix.
US Pat. No. 10,217,891

METHOD FOR PRODUCING BIOMIMETIC-INSPIRED INFRARED SENSORS FROM ZINC PHOSPHIDE MICROWIRES

UNIVERSITAT DE VALENCIA, ...

1. A method for preparation of biomimetic-inspired infrared sensors utilizing a bottom up approach, the method comprising:providing a sinusoidal alternating electrical field between a preformed electrode gap comprising two gold micro-electrodes;
providing single needles of zinc phosphide crystals optimized for growth conditions using a physical vapour transport;
immobilizing at least one individual zinc phosphide nanowire in the preformed electrode gap using dielectrophoretic manipulation; and
placing and contacting, between the two gold micro-electrodes, the at least one individual zinc phosphide nanowire in the preformed electrode gap.
US Pat. No. 10,215,073

CATALYZED SOOT FILTER FOR USE IN PASSIVE SELECTIVE CATALYTIC REDUCTION

BASF Corporation, Florha...

1. A catalyzed soot filter comprising a porous wall flow substrate, a catalyst for selective catalytic reduction (SCR), a palladium component, and a platinum component,the wall flow substrate comprising an inlet end, an outlet end, a substrate axial length extending between the inlet end and the outlet end, and a plurality of channels defined by internal walls of the wall flow substrate, wherein the plurality of channels comprise inlet channels having an open inlet end and a closed outlet end, and outlet channels having a closed inlet end and an open outlet end,
wherein the SCR catalyst is on the entire surface of the inlet channel walls and on at least a portion of the surface of the pores within the channel walls underneath the surface of the channel walls coated with the SCR catalyst,
wherein the palladium component is on a portion of the surface of the inlet channel walls and on at least a portion of the surface of the pores within the channel walls underneath the surface of the portions of the channel walls coated with the palladium component,
wherein the portion of the inlet channel walls coated with the palladium component extends from the inlet end to x % of the substrate axial length with 0 wherein the platinum component is on a portion of the surface of the outlet channel walls and on at least a portion of the surface of the pores within the channel walls within the surface of the portions of the channel walls coated with the platinum component, wherein the portion of the outlet channel walls coated with the platinum component extends from the outlet end to 100-x % of the substrate axial length.
US Pat. No. 10,214,562

PEPTIDES AND METHODS OF USING SAME

Serpin Pharma, LLC, Noke...

1. A method of improving glycemic control in a subject having hyperglycemia comprising:administering to the subject having hyperglycemia an oral formulation comprising a peptide selected from the group consisting of:
(a) a peptide comprising the amino acid sequence X1-Z1-F-N-K-P-F-X2-Z2-X3-Z3 (SEQ ID NO: 2), wherein
X1 is V or L;
X2 is V, L or M;
X3 is M, I or V;
Z1 is any amino acid;
Z2 is a sequence of any two amino acids; and
Z3 is a sequence of any five amino acids, and wherein the peptide is 21 or fewer amino acids long; and
(b) a peptide comprising the amino acid sequence VKFNKPFVFLMIEQNTK (SEQ ID NO: 1) and wherein the peptide is 21 or fewer amino acids long.
US Pat. No. 10,214,818

ANTI-CORROSIVE ZINC PRIMER COATING COMPOSITIONS COMPRISING HOLLOW GLASS SPHERES AND A CONDUCTIVE PIGMENT

1. An anti-corrosive zinc primer coating composition comprising:a) an alkali metal silicate binder system or an alkyl silicate binder system wherein the alkyl silicate binder system includes one or more alkyl silicate resins selected from the group consisting of ethyl silicates and other alkyl silicates wherein the alkyl groups contain from 1 to 8 carbon atoms,
b) zinc particles,
c) a thickening agent,
d) uncoated hollow glass microspheres, and
e) a conductive pigment selected from the group consisting of graphite, carbon black, aluminium pigments, black iron oxide, antimony-doped tin oxide, mica coated with antimony-doped tin oxide, carbon nanotubes, carbon fibres, and any mixture thereof,
wherein said silicate-based binder system is solvent-based or water-based, and wherein all uncoated hollow glass microspheres have a particle size such that the D50 diameter over the combined pool of all uncoated hollow glass microspheres is in the range of about 20 to 200 ?m.
US Pat. No. 10,216,098

TEST STRUCTURE FOR USE IN METROLOGY MEASUREMENTS OF PATTERNS

NOVA MEASURING INSTRUMENT...

1. A method for creating a test structure for use in metrology measurements of a sample pattern produced by a predetermined multi-patterning scheme, the method comprising: applying a multi-patterning process to a test site for creating a test pattern based on design rules of the sample pattern and configured to enable focusing the metrology measurements on at least one selected feature of the sample pattern, wherein said multi-patterning process applied to the test site either comprises said multi-patterning scheme and at least one additional patterning stage or comprises said multi-patterning scheme while modifying at least one patterning stage of said multi-patterning scheme, such that said multi-patterning process creates in the test site a part of the sample pattern and at least one blocking layer at least partially blocking features of the sample pattern adjacent to said at least one selected feature.
US Pat. No. 10,214,564

ANTIMICROBIAL PEPTIDES DERIVED FROM HEPATITIS B VIRUS CORE PROTEIN ARGININE-RICH DOMAIN

Academia Sinica, Taipei ...

1. A pharmaceutical composition comprising:(a) an effective amount of an isolated peptide, wherein the peptide consists of a protecting group and the amino acid sequence of SEQ ID NO:1, and exhibits an anti-bacterial or anti-fungal activity; and
(b) a pharmaceutically acceptable carrier.
US Pat. No. 10,214,565

COMPOSITIONS AND METHODS FOR TREATING, INCLUDING PREVENTING, PARVOVIRUS INFECTIONS AND RELATED DISEASES

University of Louisville ...

1. A polypeptide comprising a VP2 polypeptide with at least one amino acid modification relative to wild type VP2wherein
the wild type VP2 has the amino acid sequence of SEQ ID NO: 1 and
the at least one amino acid modification comprises a substitution at Y401, a substitution at Q399, a substitution at Q400, a substitution at Q404, a substitution at Q368, a substitution at Q369, a substitution at Y392, Y401F, Y401W, Y401A, Q368A, Q369A, Q368N, Q369N, Q399N, Q400N, Q404T, Y392A, Y392F, Q404N, Y401P, T402A, D403A, Q404A, or combinations thereof.
US Pat. No. 10,214,566

MUTANT ADENO-ASSOCIATED VIRUS VIRIONS AND METHODS OF USE THEREOF

The Regents of the Univer...

1. An infectious recombinant adeno-associated virus (rAAV) virion comprising:a) a variant AAV capsid protein comprising an amino acid sequence having at least 98% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:31, and comprising an A593E and/or a D594E substitution relative to AAV2, wherein the substitution results in decreased binding to a neutralizing antibody, compared to the binding of a wild-type AAV virion to the neutralizing antibody; and
b) a heterologous nucleic acid.
US Pat. No. 10,216,871

METHODS AND APPARATUS FOR PREDICTING GLASS DYNAMICS

Corning Incorporated, Co...

16. A method of making a glass article comprising:(I) melting batch materials to produce molten glass; and
(II) forming a glass article from the molten glass;
wherein:
(A) the batch materials comprise a plurality of viscosity-affecting components which become at least part of the glass article; and
(B) the method is characterized by said viscosity-affecting components and/or their concentrations having been selected at least in part using computer-implemented modeling where predicted/estimated non-equilibrium viscosity of the molten glass is a function of time, temperature, and composition.
US Pat. No. 10,213,544

METHODS FOR TREATING A SUSPENSION OF MONONUCLEAR CELLS TO FACILITATE EXTRACORPOREAL PHOTOPHERESIS

Fenwal, Inc., Lake Zuric...

1. A method for performing extracorporeal photopheresis of mononuclear cells comprising:withdrawing whole blood from a human subject;
introducing said whole blood into a separation chamber of an apheresis device;
separating mononuclear cells from red blood cells and plasma of said whole blood in said separation chamber;
collecting a suspension of mononuclear cells, said suspension further comprising at least residual red blood cells and residual plasma;
withdrawing said red blood cells and plasma that have been separated from said mononuclear cells from said separation chamber;
combining the collected suspension with a lysing solution;
incubating the suspension to lyse the residual red blood cells;
returning said mononuclear cell suspension to said separation chamber of said apheresis device after said withdrawing;
separating within said apheresis device said mononuclear cells from hemoglobin freed by the lysis of residual red blood cells, residual plasma and any lysing solution in said suspension;
removing from the suspension residual plasma, hemoglobin freed by the lysis of the red blood cells and any lysing solution by washing the suspension with saline by centrifugation;
adding an ultraviolet light activated agent to the saline-washed suspension;
irradiating the saline-washed suspension with ultraviolet light;
introducing said irradiated suspension into said separation chamber of said apheresis device;
concentrating the cells so as to have a smaller total volume of said suspension; and
reinfusing the suspension of concentrated cells having the smaller total volume into the human subject without increasing the total volume with additional plasma.
US Pat. No. 10,214,568

METHOD FOR PREPARING PHYCOCYANIN

Ezaki Glico Co., Ltd., O...

1. A preparation method for phycocyanin, comprising: simultaneously adding chitosan and activated carbon to a suspension of cyanobacteria containing phycocyanin to form a flocculent; and filtering the flocculent using a filter,wherein the suspension to be filtered comprises tap water or a buffer, and wherein the concentration of the chitosan in the suspension to be filtered is from 0.01 to 1% by weight and
wherein the weight ratio of chitosan:cyanobacteria is from 0.375:3 to 0.6:3.
US Pat. No. 10,214,569

FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A

GlaxoSmithKline Biologica...

1. A fusion protein of formula I:(X)m—(R1)n-A-(Y)o—B—(Z)p  (formula I)
wherein:
X is a signal peptide or MHHHHHH (SEQ ID NO. 2);
m is 0 or 1;
R1 is an amino acid;
n is 0, 1, 2, 3, 4, 5 or 6;
A is an immunogenic fragment of Protein E from Haemophilus influenzae wherein the immunogenic fragment is selected from SEQ ID NO: 122, SEQ ID NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 179, or SEQ ID NO: 180 or wherein the immunogenic fragment is a sequence having at least 95% sequence identity to any one of SEQ ID NO: 122, SEQ ID NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 179, or SEQ ID NO: 180;
Y is selected from the group consisting of GG, SG, SS, GGG and (G)h wherein h is 4, 5, 6, 7, 8, 9, or 10;
o is 0 or 1;
B is an immunogenic fragment of Pilin A (PilA) from Haemophilus influenzae, wherein the immunogenic fragment of PilA is at least 95% identical to amino acids 40-149 of SEQ ID NO. 58;
Z is GGHHHHHH (SEQ ID NO. 3); and
p is 0 or 1.
US Pat. No. 10,214,570

SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES AND METHODS OF PRODUCING SAME

THE GOVERNING COUNCIL OF ...

1. A specific inhibitor of a deubiquitinating enzyme, wherein the deubiquitinating enzyme is USP8, and wherein the inhibitor is ubiquitin variant comprising the amino acid sequence set forth in SEQ ID NO: 2 or 3.
US Pat. No. 10,216,107

TONER AND METHOD OF PRODUCING TONER

CANON KABUSHIKI KAISHA, ...

1. A toner comprising a toner particle that contains a binder resin and a wax, whereinthe solubility parameter SP of the binder resin is at least 9.4 and not more than 10.0,
the binder resin contains a resin having a structure represented by the following formula (1) in the terminal position on a main chain of the resin,
*—CO—R  formula (1)
wherein in formula (1), R represents a phenyl group or a derivative thereof, or —COOR1, R1 represents an alkyl group having 1 to 4 carbons, and * represents a bond to the main chain of the resin,
the solubility parameter SW of the wax is at least 8.1 and not more than 9.0, and
SP and SW satisfy formula (2).
|SP?SW|>0.5  formula (2)
US Pat. No. 10,214,572

DUAL-AAV VECTOR-BASED SYSTEMS AND METHODS FOR DELIVERING OVERSIZED GENES TO MAMMALIAN CELLS

University of Florida Res...

1. A polynucleotide vector system comprising i) a first AAV vector polynucleotide comprising an inverted terminal repeat at each end of the polynucleotide, and between the inverted terminal repeats a promoter followed by a partial coding sequence that encodes an N-terminal part of a selected full-length polypeptide, and ii) a second AAV vector polynucleotide comprising an inverted terminal repeat at each end of the polynucleotide, and between the inverted terminal repeats a partial coding sequence that encodes a C-terminal part of the selected full-length polypeptide, and optionally followed by a polyadenylation (pA) signal sequence, wherein the polynucleotide sequence encoding the polypeptide sequence in the first and second AAV vectors comprises polynucleotide sequence that overlaps, wherein the encoded polypeptide is human myosin VIIa, and wherein the first AAV vector polynucleotide comprises the nucleotide sequence of SEQ ID NO:1, and the second AAV vector polynucleotide comprises the nucleotide sequence of SEQ ID NO:2.
US Pat. No. 10,217,645

CHEMICAL MECHANICAL POLISHING (CMP) OF COBALT-CONTAINING SUBSTRATE

VERSUM MATERIALS US, LLC,...

1. A method of a selective chemical mechanical polishing comprising:a) providing a semiconductor substrate having a surface containing a first material and at least one second material;
wherein the first material is Co and the second material is selected from the group consisting of dielectric film, low-k and ultra low-k film, and barrier film;
b) providing a polishing pad;
c) providing a chemical mechanical polishing composition comprising
0.005 wt % to 25 wt % of an abrasive;
0.05 wt % to 10 wt % of at least two chelators;
DI water; and
at least one selected from the group consisting of:
0.0005 wt % to 0.25 wt % of a chemical additive as corrosion inhibitor or a defect reducing agent;
0.005 wt % to 0.5 wt % of a pH adjusting agent;
0.1 wt % to 10 wt % of an oxidizing agent;
0.0001 wt % to 0.10 wt % of biocide; and
0.0005 wt % to 0.15 wt % of a surfactant;
wherein the chemical mechanical polishing (CMP) polishing composition having a pH from 3.5 to 8.5; and
the at least two chelators are amino acids independently selected from the group consisting of DL-Alanine, D-Alanine, L-Alanine, Glycine, Serine, Proline, Histidine, Isoleucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Asparagine, Aspartic acid, Glutamine, Ornithine, Selenocystein, Tyrosine, Sarcosine, Bicine, Tricine, Aceglutamide, N-Acetylaspartic acid, Acetylcarnitine, Acetylcysteine, N-Acetylglutamic acid, Acetylleucine, Acivicin, S-Adenosyl-L-homocysteine, Agaritine, Alanosine, Aminohippuric acid, L-Arginine ethyl ester, Aspartame, Aspartylglucosamine, Benzylmercapturic acid, Biocytin, Brivanib alaninate, Carbocisteine, N(6)-Carboxymethyllysine, Carglumic acid, Cilastatin, Citiolone, Coprine, Dibromotyrosine, Dihydroxyphenylglycine, Eflornithine, Fenclonine, 4-Fluoro-L-threonine, N-Formylmethionine, Gamma-L-Glutamyl-L-cysteine, 4-(?-Glutamylamino)butanoic acid, Glutaurine, Glycocyamine, Hadacidin, Hepapressin, Lisinopril, Lymecycline, N-Methyl-D-aspartic acid, N-Methyl-L-glutamic acid, Milacemide, Nitrosoproline, Nocardicin A, Nopaline, Octopine, Ombrabulin, Opine, Orthanilic acid, Oxaceprol, Polylysine, Remacemide, Salicyluric acid, Silk amino acid, Stampidine, Tabtoxin, Tetrazolylglycine, Thiorphan, Thymectacin, Tiopronin, Tryptophan tryptophylquinone, Valaciclovir, Valganciclovir, and combinations thereof;
and
d) polishing the surface of the semiconductor substrate to selectively remove the first material;
wherein Co is a metal inter-connection material; at least a portion of the surface is in contact with both the polishing pad and the chemical mechanical polishing composition; and ratio of removal rate of the first material to removal rate of the second material is greater than 1.
US Pat. No. 10,216,109

ELECTROSTATIC LATENT IMAGE DEVELOPING TONER AND PRODUCTION METHOD OF THE SAME

KYOCERA Document Solution...

1. An electrostatic latent image developing toner comprisinga plurality of toner particles each including a toner core and a shell layer covering a surface of the toner core, wherein
the shell layer contains a hydrophobic thermoplastic resin and a positively chargeable hydrophilic water-insoluble resin, and
an existing amount A of alkali metal elements present in a surface layer of the shell layer measured by X-ray photoelectron spectroscopy and an existing amount B of alkali metal elements present in each of the toner particles as a whole measured by fluorescent X-ray analysis satisfy expressions (a) and (b) shown below
A?300 ppm  (a)
0.5?A/B<1.0  (b).
US Pat. No. 10,214,574

ENGINEERED CALMODULIN FOR TREATMENT OF RYANOPATHIES

Ohio State Innovation Fou...

1. An isolated polypeptide comprising the amino acid sequence SEQ ID NO:1 having at least one mutation selected from the group consisting of F13Q, T27D, T29D, M37Q, L40Q, N61D, M72Q, and M73Q.
US Pat. No. 10,216,110

TONER BINDER AND TONER

Sanyo Chemical Industries...

1. A toner binder comprising a polyester resin, wherein the toner binder satisfies Formula (1) and Formula (2) given below and has a content of a surfactant of 100 ppm or less,G?x150?10,000  (1)
G?x150/G?y150?500  (2)
wherein G?x150 represents the storage modulus (unit: Pa) at 150° C. for the tetrahydrofuran (THF)-insoluble component of the toner binder and G?y150 represents the storage modulus (unit: Pa) at 150° C. of the THF-soluble component of the toner binder,
wherein the polyester resin comprises a non-linear polyester resin (A) and a and a linear polyester resin (B),
and wherein the non-linear polyester resin (A) is either:
(i) a modified non-linear polyester resin (A1) produced by reacting a polyester resin (a1) having an active hydrogen on a terminal of the main chain with an extender (D) wherein the extender (D) is a radical reaction initiator (D2),
(ii) a modified non-linear polyester resin (A2) prepared by chemically bonding a polyester resin (a2) prepared from an alcohol component (y) and an unsaturated carboxylic acid component (z) with a carbon-carbon linkage between resin molecules by a radical addition reaction under the existence of a radical reaction initiator (D2), or
(iii) a modified non-linear polyester resin (A3) prepared by chemically bonding a polyester resin (a2) prepared from an alcohol component (y) and an unsaturated carboxylic acid component (z) with a compound (b) having a radical reactive group and having a number average molecular weight of 1,000 or less by a radical addition reaction under the existence of a radical reaction initiator (D2).
US Pat. No. 10,214,575

PROCESS FOR THE PURIFICATION OF A GROWTH FACTOR PROTEIN

OCTAPHARMA AG, Lachen (C...

1. A process of purifying a Growth Factor Protein Granulocyte Colony Stimulating Factor (G-CSF) in a purification sequence employing chromatography comprising:performing at least one chromatography step using a multimodal resin which comprises a negatively charged 2-(benzoylamino) butanoic acid ligand,
binding the G-CSF to the multimodal resin at a pH from 4 to 6.2, and
eluting the G-CSF at a pH in the range of from 5.5 to 6.5, wherein the elution is performed with an arginine buffer having a concentration in the range of from 0.1 M to 2.0 M,
optionally in combination with an affinity ligand chromatography step wherein the affinity ligand is a yeast derived Fab fragment directed toward the G-CSF.
US Pat. No. 10,216,111

ANTIMICROBIAL SULFONATED POLYESTER RESIN

Xerox Corporation, Norwa...

1. An antimicrobial core-shell resin particle comprising (a) a core comprising a sulfonated polyester resin and a nanoparticle, and (b) a shell on said core comprising a nanoparticle, wherein the nanoparticles of said core and shell comprise silver in a form selected from the group consisting of a silver salt, a silver composite and elemental silver, and further wherein the resin particle has a D50 mass median diameter of about 5 nm to about 500 nm.
US Pat. No. 10,214,576

ANTIGEN-SPECIFIC HELPER T-CELL RECEPTOR GENES

International Institute o...

1. A method for the treatment of a WT1-expressing cancer in a subject, comprising introducing a CD4+ helper T-cell into the subject,wherein the CD4+ helper T cell is obtained by introducing a TCR gene into a CD4+ T cell, wherein
(i) the TCR gene comprises a pair of polynucleotides chosen from:
(a) SEQ ID NO: 1 and SEQ ID NO: 2;
(b) SEQ ID NO: 3 and SEQ ID NO: 4;
(c) SEQ ID NO: 5 and SEQ ID NO: 6;
(d) SEQ ID NO: 3 and SEQ ID NO: 7;
(e) SEQ ID NO: 8 and SEQ ID NO: 9;
(f) SEQ ID NO: 10 and SEQ ID NO: 12;
(g) SEQ ID NO: 11 and SEQ ID NO: 12;
(h) SEQ ID NO: 13 and SEQ ID NO: 15,
(i) SEQ ID NO: 14 and SEQ ID NO: 15;
(j) SEQ ID NO: 16 and SEQ ID NO: 17;
(k) SEQ ID NO: 18 and SEQ ID NO: 19;
(l) SEQ ID NO: 20 and SEQ ID NO: 21;
(m) SEQ ID NO: 22 and SEQ ID NO: 24;
(n) SEQ ID NO: 23 and SEQ ID NO: 24;
(o) SEQ ID NO: 25 and SEQ ID NO: 26;
(p) SEQ ID NO: 27 and SEQ ID NO: 4;
(q) SEQ ID NO: 28 and SEQ ID NO: 29;
(r) SEQ ID NO: 30 and SEQ ID NO: 32;
(s) SEQ ID NO: 31 and SEQ ID NO: 32;
(t) SEQ ID NO: 33 and SEQ ID NO: 34;
(u) SEQ ID NO: 35 and SEQ ID NO: 36;
(v) SEQ ID NO: 37 and SEQ ID NO: 38;
(w) SEQ ID NO: 39 and SEQ ID NO: 40;
(x) SEQ ID NO: 41 and SEQ ID NO: 42;
(y) SEQ ID NO: 43 and SEQ ID NO: 44;
(z) SEQ ID NO: 45 and SEQ ID NO: 46;
(aa) SEQ ID NO: 47 and SEQ ID NO: 48;
(bb) SEQ ID NO: 49 and SEQ ID NO: 50;
(cc) SEQ ID NO: 51 and SEQ ID NO: 52;
(dd) SEQ ID NO: 53 and SEQ ID NO: 54;
(ee) SEQ ID NO: 55 and SEQ ID NO: 57;
(ff) SEQ ID NO: 56 and SEQ ID NO: 57; and
(gg) SEQ ID NO: 58 and SEQ ID NO: 59; or
(ii) the TCR gene comprises a pair of polynucleotides that are complementary to or degenerate of any of the pairs of polynucleotides listed in (i).
US Pat. No. 10,214,321

CONTAINER FOR A CONSUMABLE GOOD, COATED WITH A RESVERATROL CONTAINING LAYER

Barokes, PTY LTD, Victor...

1. A container for a consumable good wherein an inner surface of the container is at least partially coated with a coating layer comprising resveratrol.
US Pat. No. 10,214,577

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has a cancer overexpressing a LAMB3 polypeptide comprising the amino acid sequence of SEQ ID NO: 11, comprising administering to said patient a population of activated T cells that kill the cancer cells,wherein the activated T cells are antigen-specific CD8+ cytotoxic T cells produced by contacting CD8+ T cells with an antigen presenting cell that presents a peptide consisting of the amino acid sequence of SEQ ID NO: 11 in a complex with an MHC class I molecule on the surface of the antigen presenting cell in vitro,
wherein said cancer is selected from the group consisting of esophageal cancer, lung cancer, melanoma, uterine cancer, hepatocellular cancer, gallbladder cancer, and bile duct cancer.
US Pat. No. 10,214,578

VARIANTS OF IGG-FC FUSION THAT PROVIDE FOR SITE-SPECIFIC CONJUGATION AT THE N-TERMINUS

1. A molecule comprising a conjugated, lysine-depleted variant of an immunoglobulin G Fc (IgG-Fc-LDV) domain, comprising an amino acid sequence of IgG-Fc wherein all of the native lysine residues have been replaced with a different amino acid residue selected from the group of amino acids that excludes cysteine, methionine, proline and lysine, and wherein said IgG-Fc-LDV is conjugated in a site specific manner at its N-terminus with a polymeric molecule.
US Pat. No. 10,214,579

FC FUSION PROTEINS COMPRISING NOVEL LINKERS OR ARRANGEMENTS

BRISTOL-MYERS SQUIBB COMP...

1. An isolated nucleic acid sequence encoding a polypeptide comprising an immunoglobulin Fc domain and a heterologous polypeptide, wherein the heterologous polypeptide is fused to the N-terminus or the C-terminus of the Fc domain by a polypeptide linker, wherein the polypeptide linker comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 51-54, 63-65, and 84.
US Pat. No. 10,214,581

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS

XBIOTECH, INC., Vancouve...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a purified monoclonal antibody which specifically binds Staphylococcus aureus protein A (SpA) with a KD of less than 1×10?10 M via its Fab region paratope, wherein the monoclonal antibody is able to displace human IgG immunoglobulins bound to SpA on Staphylococcus aureus bacteria via their Fc regions, wherein the monoclonal antibody specifically binds to an amino acid sequence selected from the group of amino acid sequences consisting of SEQ ID NO: 1, SEQ ID NO: 82, SEQ ID NO: 83, SEQ ID NO: 84, and SEQ ID NO: 85.
US Pat. No. 10,214,582

ANTI-CGRP COMPOSITIONS AND USE THEREOF

ALDERBIO HOLDINGS LLC, L...

1. A method of treating, preventing, ameliorating, or reducing pain in a patient experiencing pain or comprising a pain-associated disorder, by administering to said patient an effective amount of a pharmaceutical composition comprising a humanized anti-calcitonin gene related peptide (CGRP) antibody comprising a variable light (VL) chain polypeptide comprising the complementarity-determining region (CDR) polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO: 55, SEQ ID NO: 56, and SEQ ID NO: 57, and a variable heavy (VH) chain polypeptide comprising the CDR polypeptides CDR1, CDR2, and CDR3 of SEQ ID NO: 58, SEQ ID NO: 59, and SEQ ID NO: 60.
US Pat. No. 10,214,838

HIGH MODULUS SINGLE TWISTED NYLON 6.6 YARNS

1. A dipped and heat-set polyamide 6.6 single twisted yarn, comprising a raw polyamide 6.6 yarn having a tensile stress value of greater than 1.30 cN/dtex at 4% elongation;wherein a tensile stress value of the single twisted yarn at 4% elongation is greater than 2.0 cN/dtex and less than 2.8 cN/dtex,
wherein a heat shrinkage of the single twisted yarn is greater than 4.0% and less than 7.0% determined at 177° C. under 0.045 g/dtex pretension with 2 minutes exposure time;
wherein the tensile stress values are determined with a tensile tester according to ASTM D885-16;
wherein the single twisted yarn is twisted strand.
US Pat. No. 10,214,583

SODIUM PUMP ANTIBODY AGONISTS AND METHODS OF TREATING HEART DISEASE USING THE SAME

1. A method of producing a positive inotropic effect in a mammalian host, comprises administering to said mammalian host an immunogenic formulation comprising (i) a therapeutically effective amount of one or more synthetic peptides selected from the group consisting of SEQ ID NOS: 3 and 4; (ii) a pharmaceutically acceptable carrier and adjuvant, wherein said immunogenic formulation induces endogenous production of antibodies that specifically bind to epitopes of the ?1 subunit of the (Na++K+)-ATPase (NKA) and have NKA agonist activity.
US Pat. No. 10,214,584

THERAPEUTIC PHARMACEUTICAL COMPOSITION EMPLOYING ANTI-SLC6A6 ANTIBODY

ORDER-MADE MEDICAL RESEAR...

1. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof binds SLC6A6, wherein the monoclonal antibody is at least one selected from the group consisting of:(a) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 125 in SEQ ID NO: 24 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 44 to 54, positions 70 to 76 and positions 109 to 116 in SEQ ID NO: 26 as light chain CDR1, CDR2 and CDR3, respectively;
(b) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 126 in SEQ ID NO: 28 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 46 to 57, positions 73 to 79 and positions 112 to 119 in SEQ ID NO: 30 as light chain CDR1, CDR2 and CDR3, respectively;
(c) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 128 in SEQ ID NO: 32 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 48 to 58, positions 74 to 80 and positions 113 to 120 in SEQ ID NO: 34 as light chain CDR1, CDR2 and CDR3, respectively;
(d) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 131 in SEQ ID NO: 36 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 44 to 54, positions 70 to 76 and positions 109 to 116 in SEQ ID NO: 38 as light chain CDR1, CDR2 and CDR3, respectively;
(e) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 129 in SEQ ID NO: 40 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 44 to 54, positions 70 to 76 and positions 109 to 116 in SEQ ID NO: 42 as light chain CDR1, CDR2 and CDR3, respectively; and
(f) an antibody which comprises a heavy chain variable region comprising amino acid sequences located at positions 50 to 54, positions 69 to 86 and positions 118 to 126 in SEQ ID NO: 44 as heavy chain CDR1, CDR2 and CDR3, respectively, and a light chain variable region comprising amino acid sequences located at positions 46 to 57, positions 73 to 79 and positions 112 to 119 in SEQ ID NO: 46 as light chain CDR1, CDR2 and CDR3, respectively.
US Pat. No. 10,214,585

REDUCING SYSTEMIC REGULATORY T CELL LEVELS OR ACTIVITY FOR TREATMENT OF DISEASE AND INJURY OF THE CNS

Yeda Research and Develop...

1. A method of treating an Alzheimer's Disease, the method comprising administering to an individual in need thereof a composition comprising a neutralizing antibody against a programmed death ligand 1 (PD-L1), or an anti-PD-L1 antibody fragment thereof having antagonistic or inactivating activity,wherein the composition is administered by a dosage regime comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session where the composition is administered once to the individual followed by a non-treatment period of 14 days or longer where the composition is not administered to the individual,
wherein administration of the composition transiently reduces levels of systemic immunosuppression and increases choroid plexus gateway activity in facilitating selective recruitment of immune cells into the central nervous system, thereby treating the individual.
US Pat. No. 10,213,818

METHOD FOR PREPARING HOT-ROLLED SEMIFINISHED STEEL ROLLED STOCK FOR COLD ROLLING

1. A method of removing scale from hot-rolled steel stock in preparation for cold rolling of the stock, the method comprising:preliminary cold rolling the stock having a width up to 2000 mm in mill rolls having polished working surfaces using (i) a reduction of 12 to 35% and (ii) a 3.8±0.5%/mm ratio of the reduction to a length of a deformation region of the stock;
applying spindle oil between surfaces of the stock and the working surfaces of the mill rolls; and
straightening the stock after the cold rolling of the stock.
US Pat. No. 10,214,586

PD-L1 ANTIBODIES

Eli Lilly and Company, I...

1. An antibody that binds human PD-L1 (SEQ ID NO: 1), comprising a light chain (LC) and a heavy chain (HC), wherein the light chain comprises a light chain variable region (LCVR) and the heavy chain comprises a heavy chain variable region (HCVR), and wherein the LCVR comprises light chain complementarity determining regions LCDR1, LCDR2, and LCDR3 consisting of the amino acid sequences SGSSSNIGSNTVN (SEQ ID NO: 5), YGNSNRPS (SEQ ID NO: 6), and QSYDSSLSGSV (SEQ ID NO: 7), respectively, and wherein the HCVR comprises heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3 consisting of the amino acid sequences KASGGTFSSYAIS (SEQ ID NO: 2), GIIPIFGTANYAQKFQG (SEQ ID NO: 3), and ARSPDYSPYYYYGMDV (SEQ ID NO: 4), respectively.
US Pat. No. 10,214,587

DEPLETION OF PLASMACYTOID DENDRITIC CELLS

The University of North C...

1. A method of depleting plasmacytoid dendritic cells (pDC) in a subject, comprising delivering to the subject an effective amount of an antibody or a fragment thereof that specifically binds to blood dendritic cell antigen-2 (BDCA2) and depletes pDC, thereby depleting pDC;wherein the antibody or a fragment thereof comprises a heavy chain variable region comprising the three complementarity determining regions of the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:6; and/or
the antibody or a fragment thereof comprises a light chain variable region comprising the three complementarity determining regions of the amino acid sequence of SEQ ID NO:4 or SEQ ID NO:8.
US Pat. No. 10,214,589

SITE-SPECIFIC ANTIBODY-DRUG CONJUGATION THROUGH GLYCOENGINEERING

GENZYME CORPORATION, Cam...

1. An isolated polynucleotide encoding a binding polypeptide comprising at least one modified glycan comprising at least one moiety of Formula (IV):-Gal-Sia-C(H)?N-Q-CON-X   Formula (IV),
wherein:
A) Q is NH or O;
B) CON is a connector moiety;
C) X is a diagnostic or therapeutic effector moiety;
D) Gal is a galactose moiety; and
E) Sia is a sialic acid moiety.
US Pat. No. 10,214,590

INHIBITORS OF ENDOGLIN ACTIVITY FOR THE TREATMENT OF FIBROSIS

Tufts Medical Center, Inc...

1. A method of treating a fibrotic disease in a human subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a composition comprising an antibody or antigen-binding fragment thereof that binds endoglin and inhibits endoglin activity, wherein the fibrotic disease is selected from the group consisting of lung fibrosis, kidney fibrosis, and liver fibrosis.
US Pat. No. 10,216,895

RARE VARIANT CALLS IN ULTRA-DEEP SEQUENCING

Roche Molecular Systems, ...

1. A computer-implemented method of detecting low frequency variants in a target region in a first sample, the method comprising, using a computer system:sequencing DNA fragments from one or more samples, the one or more samples including the first sample, wherein the sequencing includes targeting the target region in the DNA fragments, and wherein the sequencing is associated with an error rate;
receiving a plurality of sequence reads obtained from sequencing the DNA fragments from the one or more samples;
aligning the plurality of sequence reads to the target region of a reference sequence;
identifying a first candidate variant having a first allele at a first location of the target region based on sequence reads of the first sample differing from a reference allele at the first location of the reference sequence;
determining a first variant frequency for the first allele at the first location based on sequence reads of the first sample that align to the first location of the reference sequence, wherein the first variant frequency is equal to or lower than the error rate;
identifying the first candidate variant as corresponding to a first variant class selected from a plurality of variant classes, each variant class of the plurality of variant classes corresponding to a different type of variant;
identifying a set of second locations in the target region of the reference sequence that have the reference allele, wherein at least 50% of the other locations in the one or more samples exhibit a false positive for the first allele, and wherein the set of second locations includes the first location;
at each of the set of second locations and for each of the one or more samples:
determining a second variant frequency of the first allele based on sequence reads of the sample that align to the second location of the reference sequence, the second variant frequencies forming a statistical distribution;
comparing the first variant frequency to a statistical value of the statistical distribution to determine a probability value of the first variant frequency relative to the statistical value of the statistical distribution; and
determining whether the first candidate variant is a true positive in the first sample for the first allele by comparing the probability value to a threshold value, the threshold value differentiating between false positives and true positives for the first allele.
US Pat. No. 10,213,311

DEFORMABLE ARTICULATING TEMPLATES

ZIMMER INC., Warsaw, IN ...

1. A system for generating a patient-specific implant, the system comprising:a means for generating a three-dimensional electronic representation of a human anatomical feature including size and curvature features matching the human anatomical feature;
a means for selecting a virtual implant template from a database of virtual implant templates generated by a means for generating a series of the virtual implant templates;
a means for designing a patient-specific prosthetic implant to imitate the size and curvature features based at least in part on the selected virtual implant template; and
a means for virtually testing fit of the patient-specific prosthetic implant using the three-dimensional electronic representation of the human anatomical feature.
US Pat. No. 10,214,591

MONOCLONAL ANTIBODY TO HUMAN LINE-1 ORF2 PROTEIN AND METHOD FOR EARLY DETECTION OF TRANSFORMING CELLS IN PRE-NEOPLASTIC TISSUES OF A HUMAN SUBJECT

1. A monoclonal antibody which specifically binds to human Long Interspersed Element-1 Open Reading Frame 2p (L1-ORF2p) obtained from hybridoma ChA1-L1 deposited under the Budapest Treaty on Dec. 2, 2014, under accession number 14120202 at the European Collection of Cell Cultures (Culture Collections Public Health England, Porton Down Salisbury Wiltshire, SP40JG).
US Pat. No. 10,214,592

PROTEIN ASSAY METHOD SPECIFIC TO TRACP-5B (TARTRATE RESISTANT ACID PHOSPHATASE 5B)

NITTO BOSEKI CO., LTD., ...

1. A monoclonal antibody which recognizes an epitope based on a steric structure of TRACP-5b (Tartrate-Resistant Acid Phosphatase 5b); which does not recognize any of epitopes formed of a primary structure of linear sequence of TRACP-5b; and which does not bind to TRACP-5a (Tartrate-Resistant Acid Phosphatase 5a), wherein said antibody is produced by Hybridoma TrK-126 of Accession number NITE BP-01866 or Hybridoma TrK-127 of Accession number NITE BP-01867.
US Pat. No. 10,216,897

CONSTRUCTION OF DIVERSE SYNTHETIC PEPTIDE AND POLYPEPTIDE LIBRARIES

I2 PHARMACEUTICALS, INC.,...

1. A method of making a library of antibody heavy or light chains, comprising the steps of(a) aligning a plurality of antibody heavy or light chain sequences comprising one or more CDR sequence motifs;
(b) creating a first dataset by applying a predetermined combination of two or more filters based on parameters of said antibody heavy or light chain sequences;
(c) analyzing said first dataset for positional amino acid usage frequency within at least one of said CDR sequence motifs;
(d) creating a second dataset characterized by a minimum threshold amino acid usage frequency at one or more amino acid positions within said CDR sequence motif; and
(e) synthesizing an antibody heavy or light chain library designed with the aid of the first and second datasets identified, by generating a discrete number of defined or degenerate oligonucleotides such that only defined amino acids are generated.
US Pat. No. 10,214,593

ANTI-IDIOTYPE ANTIBODY AGAINST ANTI-C-MET ANTIBODY

SAMSUNG ELECTRONICS CO., ...

1. An anti-idiotype antibody or antigen-binding fragment thereof that specifically binds to an idiotype of an anti-c-Met antibody comprising:(a) a CDR-H1 comprising the amino acid sequence of SEP ID NO: 116, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 126, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 140, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 156, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 173, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 189;
(b) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 115, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 125, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 139, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 155, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 172, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 188;
(c) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 117, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 127, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 141, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 157, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 174, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 190;
(d) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 118, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 128, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 142, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 158, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 175, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 191;
(e) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 117, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 129, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 143, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 159, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 176, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 192;
(f) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 118, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 130, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 144, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 160, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 177, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 193;
(g) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 115, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 131, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 145, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 161, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 178, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 191;
(h) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 116, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 132, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 146, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 162, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 178, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 194;
(i) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 119, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 133, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 147, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 163, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 179, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 189;
(j) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 119, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 134, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 148, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 164, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 180, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 195; or
(k) a CDR-H1 comprising the amino acid sequence of SEQ ID NO: 120, a CDR-H2 comprising the amino acid sequence of SEQ ID NO: 126, a CDR-H3 comprising the amino acid sequence of SEQ ID NO: 149, a CDR-L1 comprising the amino acid sequence of SEQ ID NO: 165, a CDR-L2 comprising the amino acid sequence of SEQ ID NO: 181, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO: 196.
US Pat. No. 10,216,898

BIOINFORMATICS SYSTEMS, APPARATUSES, AND METHODS EXECUTED ON AN INTEGRATED CIRCUIT PROCESSING PLATFORM

Edico Genome Corporation,...

1. A system for executing a sequence analysis on a plurality of reads of genomic data using an index of genetic reference data stored in a memory, each read of genomic data representing a sequence of nucleotides, the genetic reference data representing one or more genetic reference sequences, the system comprising:a cloud-based server; and
an integrated circuit connected with the cloud-based server, the integrated circuit being formed of a set of pre-configured hardwired digital logic circuits that are interconnected by a plurality of physical electrical interconnects, one or more of the plurality of physical electrical interconnects comprising a memory interface for the integrated circuit to access the memory, the hardwired digital logic circuits being arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis on the plurality of reads of genomic data, the set of processing engines comprising a mapping module in a first hardwired configuration to:
receive a read of genomic data via one or more of the plurality of physical electrical interconnects;
extract a portion of the read to generate a seed, the seed representing a subset of the sequence of nucleotides represented by the read;
calculate a first address within the index based on the seed;
access the address in the index in the memory;
receive a record from the address, the record representing position information in the genetic reference sequence;
determine, based on the record, one or more matching positions from the read to the genetic reference sequence; and
output, to the cloud-based server, at least one of the matching positions to the memory via the memory interface.
US Pat. No. 10,214,595

NANOCELLULOSE COMPOSITIONS AND PROCESSES TO PRODUCE SAME

API Intellectual Property...

1. A composition comprising hydrophobic nanocellulose and lignin, wherein hydrophobicity of said nanocellulose arises from said lignin, wherein said nanocellulose contains about 0.5 wt % sulfur content or less, and wherein said nanocellulose is characterized by a crystallinity of at least 60%.
US Pat. No. 10,214,596

CHITIN NANOCRYSTALS AND PROCESS FOR PREPARATION THEREOF

1. A process for producing chitin nanocrystals (ChNCs) comprising contacting a chitinous material with a sufficient amount of an inorganic persulfate to produce chitin nanocrystals from the chitinous material.
US Pat. No. 10,214,341

AEROSOL PRODUCT FOR FORMING COOLING GEL COMPOSITION FOR HUMAN BODY

Toyo Aerosol Industry Co....

1. An aerosol product for forming a cooling gel composition for a human body, comprising:a double-structure container including a propellant filling space and two independent liquid concentrate filling spaces and having a discharging mechanism for simultaneously discharging contents of the two liquid concentrate filling spaces, wherein
the propellant filling space in the double-structure container comprises a propellant composed of a compressed gas,
a first liquid concentrate filling space of the two independent liquid concentrate filling spaces in the double-structure container is filled with a first liquid concentrate composition, and a second liquid concentrate filling space of the two independent liquid concentrate filling spaces in the double-structure container is filled with a second liquid concentrate composition,
the first liquid concentrate composition contains a hydrated endothermic substance dispersed in a liquid medium composed of a solvent containing a viscosity modifier and has a viscosity of 1,000 to 125,000 mPa·s at a temperature of 20° C., the hydrated endothermic substance contained in the first liquid concentrate composition comprises at least one selected from the group consisting of xylitol, sorbitol, erythritol, maltitol, lactitol, mannitol, and palatinit, a content ratio of the hydrated endothermic substance in the first liquid concentrate composition is 1% to 30% by mass per 100% by mass of the first liquid concentrate composition, a content ratio of the solvent in the first liquid concentrate composition is 60% by mass or more per 100% by mass of the first liquid concentrate composition, a content ratio of the viscosity modifier in the first liquid concentrate composition is 0.05% to 10% by mass per 100% by mass of the first liquid concentrate composition;
the second liquid concentrate composition contains water and a viscosity modifier and has a viscosity of 1,000 to 125,000 mPa·s at a temperature of 20° C., a content ratio of water in the second liquid concentrate composition is 49.8% to 95% by mass per 100% by mass of the second liquid concentrate composition, a content ratio of the viscosity modifier in the second liquid concentrate composition is 0.05% to 5% by mass per 100% by mass of the second liquid concentrate composition, and
the first liquid concentrate composition discharged from the first liquid concentrate filling space and the second liquid concentrate composition discharged from the second liquid concentrate filling space are mixed to form a cooling gel composition for the human body.
US Pat. No. 10,214,855

METHOD FOR MAKING MODIFIED CELLULOSE PRODUCTS

UPM-KYMMENE CORPORATION, ...

1. A method for making modified cellulose products, comprisingprocessing cellulose pulp to modified cellulose pulp at a manufacturing location to increase the susceptibility of fibers to disintegration,
setting the modified cellulose pulp to a suitable dry matter content, and
transporting the modified cellulose pulp at set dry matter content to a location of use, which is a different location from the manufacturing location, where the modified cellulose pulp is disintegrated to nanofibrillar cellulose, wherein the dry matter content of the modified cellulose pulp is set to 20-60%.
US Pat. No. 10,214,601

NON-STRETCHED POLYPROPYLENE-BASED FILM

LG Chem, Ltd., Seoul (KR...

1. A non-stretched polypropylene-based film comprising a propylene-ethylene-1-butene terpolymer which has a melting point (Tm) of 125 to 135° C., a molecular weight distribution (Mw/Mn, PDI) of 2.3 to 3.5, and a xylene soluble (Xs) content of 2.0 wt° or less,wherein the terpolymer has a crystallization temperature (Tc) of 75 to 87° C.,
wherein the terpolymer has MFR2,16(g/10 min, measured at 230° C. according to ASTM1238) of 5 to 7, and
wherein, when heat-sealed at 134° C. and 0.2 MPa for 1 second, a sealing strength of the terpolymer is 300 to 500 g/15mm.
US Pat. No. 10,215,882

TAGGED CHEMICAL DIVERTER

CARBO CERAMICS INC., Hou...

1. A method for detecting diverter material placed in a borehole region, comprising:(a) obtaining a first data set by:
(i) lowering into a borehole traversing the borehole region a pulsed neutron logging tool comprising a pulsed neutron source and a detector,
(ii) emitting pulses of neutrons from the pulsed neutron source into the borehole region,
(iii) detecting capture gamma rays resulting from nuclear reactions in the borehole region;
(b) placing a diverter material comprising aqueous-swellable particles and a thermal neutron absorbing material into the borehole region;
(c) obtaining a second data set by:
(i) emitting pulses of neutrons from the first pulsed neutron source or a second pulsed neutron source into the borehole region,
(ii) detecting capture gamma rays in the borehole; and
(d) comparing the first data set and the second data set to determine the location of diverter material placed in the borehole region.
US Pat. No. 10,213,579

CATHETER FOR CELL INFUSION AND METHOD OF PRESSURE REGULATION

SciCoTec GmbH, Gruenwald...

1. A method of injecting stem cells obtained from body tissue of a human donor subject to be engrafted at a predetermined target site of damaged or failing tissue of a recipient subject for repair or replacement of such tissue, including the steps of:selecting a balloon catheter having a central lumen open at both ends and characterized by two different interconnected diameters for use in the cell infusion, including a central lumen diameter size and outer diameter length distal portion relatively smaller than the central lumen diameter size and shorter than the outer diameter length of the proximal portion, such that a constriction is formed in the central lumen at the junction between the proximal and distal portions of the catheter, the distal portion outer diameter length being selected to enable its entry into a natural vessel or duct of smaller lumen diameter to the target site while the proximal portion is navigable through natural vessels or ducts of larger lumen diameter leading to but unnavigable into such smaller lumen diameter natural vessel or duct in the body of the recipient subject;
inserting the distal portion end of the catheter for advancement through the system of natural vessels or ducts of the recipient subject's body to position the central lumen opening at the tip of the catheter at the distal portion end in proximity to the target site;
inflating the catheter's balloon located rearward of the opening at the catheter tip to block antegrade natural fluid flow in the natural vessel or duct at the target site while the catheter is in said position;
while the antegrade blockage is maintained, introducing under adjustable pressure into the central lumen opening at the proximal portion end of the catheter a volume of biocompatible fluid containing a predetermined quantity of the stem cells nominally of sizes larger than diameters of capillaries of the capillary bed in the natural vessel or duct at the target site, sensing sudden increase in resistant pressure indicative of obstruction to automatically increase the level of ejection pressure to overcome resistant pressure from the smaller central lumen diameter of the catheter's distal portion and buildup of cells in the fluid flow at the catheter tip and occlusion of the smaller capillaries, for an interval of time sufficient to clear the obstruction and thereupon reduce the ejection pressure to a level sufficient to allow concentration of at least a substantial percentage of the predetermined quantity of the introduced cells to enter and remain in the natural vessel or duct at the target site so as to infiltrate the tissue to be repaired or replaced underlying an endothelial barrier of the capillary bed when ejected from the central lumen opening at the catheter tip, rather than being forced by excessive ejection pressure rapidly away from the capillary bed thereat, the central lumen diameter sizes of the proximal and distal portions of the catheter being selected to produce increasing velocity and reduced pressure drop of cell flow through the catheter's central lumen at said constriction, and the inflated balloon serving as well to block retrograde flow of ejected cells through the natural vessel or duct from the target site;
monitoring the ejection pressure and adjusting the pressure at which the fluid containing the cells is introduced accordingly, so as to maintain said sufficient level of ejection pressure and thereby force the cells to undergo extravasation through the endothelial barrier for infiltration into underlying damaged or failing tissue at the target site toward achieving repair or replacement thereof; and
ceasing carrier fluid introduction, deflating the balloon, and removing the catheter from the recipient subject's body to enable restoration of natural fluid flow at the target site before an occurrence of underlying tissue damage.
US Pat. No. 10,214,603

POLYETHYLENE COMPOSITIONS AND METHODS OF MAKING AND USING SAME

Chevron Phillips Chemical...

1. A polyolefin having a long chain branching distribution per molecule in a range of from about 0 to about 20 at a Mw of the polyolefin ranging from about 1.00E+05 g/mol to about 3.00E+06 g/mol which when extruded at a temperature in a range of from about 590° F. to about 645° F. and then coated onto a substrate at a rate of from about 300 ft/min to about 1000 ft/min has an edge weave of from about 0 in/side to about 2.5 in/side and a neck-in of less than about 3.0 in/side.
US Pat. No. 10,214,604

VINYL ALCOHOL POLYMER AND USE THEREOF

KURARAY CO., LTD., Kuras...

1. A vinyl alcohol-based polymer having an ethylenic double bond with a saponification degree of 70 mol % or more, whereinthe vinyl alcohol-based polymer is water-soluble;
a molar ratio of the ethylenic double bond to a total of vinyl alcohol units and vinyl acetate units is 0.05/100 to 2/100; and
a limiting viscosity [?] and a weight-average molecular weight Mw of a vinyl ester-based polymer which is produced by esterifying the vinyl alcohol-based polymer satisfy formulas (1) and (2):
4.7?log Mw?6.3  (1)
0.60<(log [?]+3.75)/log Mw<0.69  (2).
US Pat. No. 10,213,837

TITANIUM POWDER CONTAINING SOLID-SOLUTED NITROGEN, TITANIUM MATERIAL, AND METHOD FOR PRODUCING TITANIUM POWDER CONTAINING SOLID-SOLUTED NITROGEN

HI-LEX CORPORATION, Hyog...

1. A method for producing titanium powder containing a solid-soluted nitrogen, the method comprising:heating titanium powder comprising titanium particles in a nitrogen-containing atmosphere to dissolve nitrogen atoms and form a solid solution of nitrogen atoms in a matrix of the titanium particles,
wherein
a heating temperature for forming the solid solution of the nitrogen atoms in the matrix of the titanium particles is 400° C. or more and 600° C. or less, and
the heating causes the titanium particles to have a nitrogen content of 0.1 mass % or more and 0.65 mass % or less.
US Pat. No. 10,214,605

METHOD FOR PRODUCING POLYCARBOXYLIC ACID POLYMER

NIPPON SHOKUBAI CO., LTD....

1. A method of producing a polycarboxylic acid-based polymer, comprising adding a monomer composition containing (meth)acrylic acid and/or salts thereof, a monomer composition containing maleic acid and/or salts thereof, a monomer composition containing (meth)acrylic acid and/or salts thereof and a sulfonic group-containing compound, a monomer composition containing maleic acid and/or salts thereof and a sulfonic group-containing compound, or a monomer composition containing (meth)acrylic acid and/or salts thereof, maleic acid and/or salts thereof and a sulfonic group-containing compound to a reaction vessel to perform a polymerization reaction,wherein the polycarboxylic acid-based polymer is a homopolymer of poly(meth)acrylic acid and/or salts thereof, a homopolymer of polymaleic acid and/or salts thereof, a copolymer of (meth)acrylic acid and/or salts thereof and a sulfonic group-containing compound, a copolymer of maleic acid and/or salts thereof and a sulfonic group-containing compound, or a copolymer of (meth)acrylic acid and/or salts thereof, maleic acid and/or salts thereof and a sulfonic group-containing compound,
the method further comprising adding a defoaming agent by a time when 100 mass % of a total amount of the monomer composition is added.
US Pat. No. 10,218,194

LITHIUM-BASED BATTERY PACK FOR A HAND HELD POWER TOOL

MILWAUKEE ELECTRIC TOOL C...

1. A battery pack comprising:a housing connectable to and supportable by a hand held power tool;
a plurality of battery cells supported within the housing, the plurality of battery cells connected in a combined series-parallel configuration, each of the plurality of battery cells having a lithium-based chemistry, each of the plurality of battery cells being cylindrical and having a cell diameter and a cell length, the cell length being at least about two times the cell diameter;
first and second terminals for electrically connecting the battery pack to the hand held power tool; and
a circuit configured to control a discharge of the plurality of battery cells to produce a discharge current from the plurality of battery cells, an average of the discharge current produced by the plurality of battery cells being greater than or equal to approximately 20 amps.
US Pat. No. 10,214,608

SURFACE MODIFICATION METHOD AND SURFACE-MODIFIED BODY

SUMITOMO RUBBER INDUSTRIE...

1. A method for suppressing adsorption of proteins or cells to an object made of a rubber vulcanizate or a thermoplastic resin, the method comprising:a step 1 of forming polymerization initiation points on a surface of the object; and
a step 2 of radically polymerizing a hydrophilic monomer starting from the polymerization initiation points by irradiation with UV light having a wavelength of 300 to 400 nm for 3 minutes or more in the presence of an alkali metal salt so as to grow polymer chains on the surface of the object,
wherein the alkali metal salt is at least one selected from the group consisting of halogenated alkali metal salts, alkali metal carbonates, alkali metal bicarbonates, alkali metal hydrogen carbonates, alkali metal nitrates, alkali metal sulfates, alkali metal bisulfates, alkali metal phosphates, alkali metal hydroxides, alkali metal acetates, alkali metal citrates, and alkali metal lactates; and
wherein the alkali metal salt is a water-soluble lithium, sodium, potassium, rubidium or cesium salt.
US Pat. No. 10,214,612

EPOXY RESIN COMPOSITION COMPRISING 2-(2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL)PROPANE-1,3-DIAMINE AS HARDENER

Evonik Degussa GmbH, Ess...

1. An epoxy resin composition comprising:A) an epoxy compound
and
B) a hardener composition comprising:
B1) from 0.1%-100% by weight of 2-(2,2,6,6-tetramethylpiperidin-4-yl)propane-1,3-diamine
and
B2) from 99.9%-0% by weight of at least one further diamine and/or polyamine,
where the stoichiometric ratio of the epoxy groups of A) and the number of active hydrogen atoms of the functional groups of B) varies from 1:2 to 2:1,
C) optionally from 0.1% to 10% by weight of at least one hardening accelerator,
D) optionally at least one latent hardener,
where the amounts of A)-D) add up to 100% by weight,
E) optionally further additives.
US Pat. No. 10,214,613

POLYESTER RESINS BASED ON FATTY ACIDS THAT HAVE A SHORT OIL LENGTH, AQUEOUS DISPERSIONS AND ASSOCIATED COATINGS

Arkema France, Colombes ...

1. A polyester alkyd resin,derived from at least one fatty acid and an alcohol component comprising at least one polyol of functionality ranging from 2 to 10, and
an acid component comprising, in addition to said fatty acid, from 45% to 75% by weight, relative to the total weight of said resin, of rosin and/or rosin derivatives bearing at least one carboxylic acid function,
said resin having a zero oil content (0%) and said fatty acid being selected from the group consisting of non-oxidizable fatty acids with a corresponding content of oxidizable unsaturations that is 0 mmol per g of dry resin or said resin having an oil content up to 5% and wherein in addition to said fatty acid selected from the group consisting of non-oxidizable fatty acids, further comprising in minor weight proportions the oxidizable fatty acid leading to said oil content ranging up to 5%, and having a weight ratio of oxidizable fatty monoacids relative to the overall fatty acids of 0 or higher than 0 and corresponding to said oil content up to 5%,
said resin having an acid number less than 8 and a number-average molecular mass Mn, measured by GPC as polystyrene equivalents in THF, ranging from 1,000 to 10,000,
wherein said non-oxidizable fatty acid is selected from the group consisting of fatty acid oligomers.
US Pat. No. 10,214,615

POLYIMIDE COMPOSITION

Croda International Plc, ...

1. Polyimide formed from at least one dianhydride and at least one dimer fatty diamine and at least one aromatic diamine,wherein at least 50 wt. % of the total amount of diamine is comprised of dimer fatty diamine, and
wherein at least one aromatic diamine is present in an amount of at least 5 wt. % of the total diamine,
wherein the dimer fatty diamine has a trimer fatty triamine content of less than 1 wt. %,
wherein the polyimide has a weight average molecular weight in the range 10,000 to 300,000, and
wherein the at least one aromatic diamine is selected from the group consisting of 4,4?-diaminodiphenyl ether, 3,4?-diaminodiphenyl ether, 3,3?-diaminodiphenyl ether, o-tolidine, m-tolidine, 4,4?-diaminobenzanilide, p-phenylenediamine, and m-phenylenediamine.
US Pat. No. 10,214,616

ANAEROBICALLY STORED BIOMASS HAVING HIGHLY REDUCED OR NO FERMENTATION

1. An anaerobically stored wet biomass mash obtained by a method comprising:providing a composition comprising a biomass, wherein the biomass comprises a Neutral Detergent Fiber (NDF) value of less than 45% of dry matter content and lignin in an amount of less than 10% of the dry matter content, and wherein the biomass is selected from the group consisting of alfalfa, corn, grass, clover, beet crop, sugar cane, pea, bean, whole crop cereal, sorghum, sunflower, and mixtures thereof;
subjecting the composition to a pH adjusting step under anaerobic conditions, in which the pH is adjusted with a base to a pH of 7.5 or more at a temperature of 1 to 40° C. for a period of at least 2 days, thereby generating a pH adjusted wet biomass mash for anaerobic storage.
US Pat. No. 10,217,947

ORGANIC COMPOUND AND ELECTRONIC DEVICE USING SAME

NICHEM FINE TECHNOLOGY CO...

1. An organic compound comprising:a electron donating 4,4?-substituted cis-stilbene segment;
a bridge atom segment having a bridge atom with four bonds, and the bridge atom is connected to the electron donating 4,4?-substituted cis-stilbene segment with two of the four bonds to form a 7-membered ring structure; and
an imidazole segment connected to the electron donating 4,4?-substituted cis-stilbene segment.
US Pat. No. 10,215,897

INFRARED LIGHT ABSORBING AMINIUM AND DIIMMONIUM COMPOSITIONS

NOTICXE, INC., Dayton, O...

1. An infrared light absorbing aminium composition comprising:an aminium radical cation that has at least one absorption peak in the near infrared wavelength region between about 700 and 1500 nm and having the formula:
[4-R1R2N—C6H3CH3][4-R3R4N—C6H3CH3][4-R5R6N—C6H3CH3]N+where R1 through R6 are identical or different, optionally are linked to form rings, and are each an alkyl group, an arylalkyl group, an alkyl ether, or hydroxyalkyl group, andan anionic borate moiety having the formula:
[BXaYb]?in which a and b are integers, and a ranges from 0 to 3, b ranges from 1 to 4, and a+b=4; each X is a halogen atom, which is identical or different or an OH functional group, and each Y, which is identical or different, is a phenyl radical, which is substituted by at least one element or electron-withdrawing substituent or by one or more halogen atoms, or an aryl radical containing at least two aromatic ring members, which is optionally substituted.
US Pat. No. 10,214,618

LOW DENSITY CORING MATERIAL

Illinois Tool Works Inc.,...

1. A process for making a composition for a low density coring material comprising:providing one or more resins, a monomer, and a dispersion aid;
performing a first mixing of the one or more resins, the monomer, and the dispersion aid with a mixer to form a resin mixture;
adding one or more accelerators into the resin mixture;
performing a second mixing of the added one or more accelerators and the resin mixture;
adding microspheres to the mixture of the one or more accelerators and the resin mixture while performing a third mixing; and
performing a fourth mixing and filtering the composition through a mesh to yield the low density coring material, the coring material having a cured state and an uncured state, the viscosity of the coring material in the uncured state is in a range of from 7,000 to 13,000 cps, wherein a density of the cured coring material is less than about 5.0 lbs/gal, a layer of low density coring material having a wet thickness from 15 to 40 mils per pass.
US Pat. No. 10,214,620

NANO-REINFORCEMENT FILLER MATERIAL FOR EPOXY RESIN SYSTEMS AND METHODS OF MAKING THE SAME

The Boeing Company, Chic...

1. A method of making a nano-reinforcement filler material for an epoxy resin system for a composite structure, the method comprising the steps of:forming a polymer suspension comprising a plurality of polymer nanoparticles suspended in deionized (DI) water;
sonicating the polymer suspension to obtain a sonicated polymer suspension; forming a graphene oxide (GO) suspension comprising a plurality of graphene oxide (GO) sheets suspended in deionized (DI) water;
sonicating the graphene oxide (GO) suspension to obtain a sonicated graphene oxide (GO) suspension;
mixing the sonicated polymer suspension and the sonicated graphene oxide (GO) suspension together in a mixing vessel, to obtain a sonicated mixture; and
heating the sonicated mixture in an inert atmosphere at an effective temperature in a range of from 7020 C. (seventy degrees Celsius) to about 100° C. (one hundred degrees Celsius), and using an electrostatic process to uniformly wrap individual polymer nanoparticles with individual graphene oxide (GO) sheets, via an electrostatic interaction reaction, to obtain the nano-reinforcement filler material comprising polymer-GO core-shell nanoparticles.
US Pat. No. 10,214,621

BINARY PROCESS FOR MANUFACTURE OF DIPPED LATEX PRODUCTS

TTK Healthcare Limited, ...

1. A binary process for manufacturing dipped latex product, the said process comprising:preparing a first latex mixture Formulation A comprising latex, one or more accelerators, and one or more surfactants but no curing agents;
preparing a second latex mixture Formulation B comprising latex, one or more curing agents, and one or more surfactants but no curing accelerators;
dipping one or more formers into the Formulations A and B separately in order to form a plurality of coatings/layers of the Formulations A and B; and
curing the plurality of coatings/layers on the formers to form the dipped latex products.
US Pat. No. 10,214,625

POLYOLEFIN NANOCOMOSITES MATERIALS

Basell Poliolefine Italia...

1. A process for the preparation of a polyolefin nanocomposite material comprising:melt mixing
(i) a crystalline or semi-crystalline polyolefin resin component (A),
(ii) a nanosized mineral filler comprising or substantially consisting of a hydrotalcite (B), and
(iii) a compatibilizer,
wherein the amount of the hydrotalcite is from 0.02 to 6 parts by weight per 100 parts by weight of the nanocomposite material, and the ratio MFR (1)/MFR (2) of the melt flow rate value MFR (1) of component (A) to the melt flow rate value MFR (2) of the polyolefin nanocomposite material is of at least 1.02, and
wherein the melt mixing is at a shear mixing rate ranging from 30 to 300 sec?1.
US Pat. No. 10,214,627

STABILISED RESIN COMPOSITION

SABIC Global Technologies...

1. A resin composition comprising(A) a polypropylene resin,
(B) an optionally substituted linear or branched alkyl ester of 3-(alkylated 4?-hydroxyphenyl) propionic acid having a molecular weight of 750 g/mol or less,
(C) a hindered amine light stabiliser, having a molecular weight of 1250 g/mol or more, wherein the hindered amine is comprised in the backbone of the hindered amine light stabiliser molecule, and
(D) a thiosynergist comprising a sulphur-based hydroperoxide decomposer.
US Pat. No. 10,214,628

PLASTICIZER BLENDS AND PLASTISOL COMPOSITIONS COMPRISED THEREOF

Emerald Kalama Chemical, ...

1. A plastisol composition comprising:a) a polymer;
b) an organic solvent as a diluent to reduce viscosity wherein the organic solvent is a mineral spirit, cycloaliphatic or other petroleum distillate, detergent alkylate or isoparaffin; and,
c) a plasticizer blend comprising a dibenzoate plasticizer as the primary plasticizer mixed in combination with a compatibilizing component consisting of dioctyl succinate, 1,2-propylene glycol dibenzoate or 3-phenyl propyl benzoate, present in the plastisol in an amount of about 30 to about 120 phr total plasticizer content,
wherein 1,2-propylene glycol dibenzoate is not used as a compatibilizing component when it comprises a part of the primary plasticizer.
US Pat. No. 10,214,630

NATURAL CRYSTALLINE COLORANT AND PROCESS FOR PRODUCTION

1. A process, comprising:purifying algae containing pigments by removing at least a portion of non-pigment compounds from the algae to recover a purified pigment;
drying the purified pigment by refractive window drying to produce a crystalline product and milling the crystalline product.
US Pat. No. 10,213,865

METHOD FOR WELDING A CASE HARDENED COMPONENT

Whirlpool Corporation, B...

1. A method for producing a welded part comprising a first component welded to a second component, the method comprising:case hardening the surface of the first component by a salt bath nitriding process; and
after case hardening the surface of the first component, welding the case hardened first component to the second component by a gas metal arc welding process using an aluminum-bronze wire electrode.
US Pat. No. 10,214,635

SULFUR-CROSSLINKABLE RUBBER MIXTURE AND VEHICLE TIRE

Continental Reifen Deutsc...

1. A sulfur-crosslinkable rubber mixture comprising:at least one diene rubber;
10 to 200 phr of at least one silica; and,
2 to 20 phf of at least one silane having the general empirical formula:
[(R1)3Si—X]mSn(R2)2-m wherein the R1 radicals may be the same or different within one molecule, wherein the R1 radicals selected from the group consisting of alkoxy groups having 1 to 10 carbon atoms, cyclic dialkoxy groups having 2 to 10 carbon atoms, cycloalkoxy groups having 4 to 10 carbon atoms or phenoxy groups, aryl groups having 6 to 20 carbon atoms, alkyl groups having 1 to 10 carbon atoms, alkenyl groups having 2 to 20 carbon atoms, aralkyl groups having 7 to 20 carbon atoms, and halides, wherein X is a polar organic urea-containing group, wherein m assumes the value of 1 or 2, wherein n is an integer from 1 to 8, and wherein R2 is a hydrogen atom or an acyl group having 1 to 20 carbon atoms; and,wherein the polar organic urea-containing X group comprises at least one urea derivative as polar functionality which bears an organic hydrocarbyl group on the two nitrogen atoms, wherein the group between the first nitrogen atom of the urea-containing group and the sulfur of the Sn group is aliphatic, and wherein the group between the second nitrogen atom of the urea-containing group and the silicon atom of the (R1)3Si group is aliphatic or aromatic.
US Pat. No. 10,214,636

RUBBER COMPOSITION FOR A TIRE TREAD

KUMHO TIRE CO., INC., Gw...

1. A rubber composition for a tire tread, comprising:6 to 20 parts by weight of a silane coupling agent having a thioester group and SiO bond; and
1 to 20 parts by weight of terpene resin having a softening point of 130° C. or more and a weight average molecular weight of 1,000 or more, to 100 parts by weight of raw rubber,
wherein the raw rubber comprises:
10 to 30% by weight of end modified styrene-butadiene rubber, in which a styrene unit content is 20% by weight or less and a vinyl unit content is 30% by weight or less,
30% to 50% by weight of styrene-butadiene rubber, and
20% to 60% by weight of butadiene rubber or natural rubber.
US Pat. No. 10,214,638

RUBBER COMPOSITION COMPRISING AN AROMATIC DICYCLOPENTADIENE RESIN

Compagnie Generale Des Et...

1. A rubber composition based on at least one styrene/butadiene copolymer SBR, the SBR having a content of greater than or equal to 50 parts per hundred parts of elastomer, phr, a reinforcing filler comprising carbon black with a CTAB specific surface area of greater than or equal to 90 m2/g, wherein the composition comprises an aromatic dicyclopentadiene plasticizing resin comprising at least 80% by weight of units selected from each of styrene, ethylene and dicyclopentadiene units, at a content ranging from 2 to 40 phr, the composition containing less than 5 phr of another plasticizer.
US Pat. No. 10,214,639

POST CONSUMER RECYCLED RESIN COMPOSITION AND MANUFACTURE OF TUBES THEREFROM

Essel Propack Ltd., Mumb...

1. A laminate comprising: an outer layer of a post-consumer recycled polymer composition consisting of 80% to 95% (w/w) of a post-consumer recycled resin, and 5% to 20% (w/w) of ethylene alpha olefin co-polymer; a middle layer of post-consumer recycled polymer composition consisting of 80% to 95% (w/w) of a post-consumer recycled resin, and 5% to 20% (w/w) of ethylene alpha olefin co-polymer; an inner layer comprising a virgin polyethylene resins, and wherein the post-consumer recycled resin is a High Density Polyethylene (HDPE) resin.
US Pat. No. 10,214,640

SOFT AND FLEXIBLE POLYOLEFIN COMPOSITION

Basell Poliolefine Italia...

1. A polyolefin composition comprising:A) from about 63 to about 78% by weight, based upon the total weight of the polyolefin composition, of a copolymer of butene-1 with ethylene having a copolymerized ethylene content of up to about 18% by mole, based upon the molar composition of the copolymer, and no melting peak detectable at the DSC at the second heating scan and
B) from about 22 to about 37% by weight, based upon the total weight of the polyolefin composition, of (i) a propylene homopolymer, or (ii) a propylene copolymer, or (iii) a mixture of two or more of (i) and (ii), having a melting temperature Tm, measured by DSC at the second heating scan, of from about 130° C. to about 165° C.,wherein (i) the amounts of A) and B)=100 and referred to as the total weight of A)+B) and the DSC second heating scan is carried out with a heating rate of 10° C. per minute and (ii) having a melting enthalpy ?Hfus, measured by DSC at the second heating scan of from about 7 to about 30 J/g.
US Pat. No. 10,214,641

AQUEOUS ORGANIC SILICON FLUORO-CONTAINING POLYMER DISPERSION AND METHOD FOR MANUFACTURING THE SAME

GRAND TEK ADVANCE MATERIA...

1. An aqueous organic silicon fluoro-containing polymer dispersion, comprising:100 parts by weight of a poly(vinylidene difluoride-hexafluoropropylene);
10 to 30 parts by weight of an organic silicon emulsion; and
an acrylate polymer, wherein the acrylate polymer and the sum of the poly(vinylidene difluoride-hexafluoropropylene) and the organic silicon emulsion have a weight ratio of 30:100 to 50:100.
US Pat. No. 10,214,642

THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE MANUFACTURED THEREFROM

LG CHEM, LTD., Seoul (KR...

1. A thermoplastic resin composition, comprising:7 to 50% by weight of an acrylic rubber-aromatic vinyl compound-vinyl cyan compound graft copolymer (a);
7 to 40% by weight of a silicone-acrylate based copolymer (b);
5 to 20% by weight of a (meth)acrylic acid alkyl ester compound-aromatic vinyl compound-vinyl cyan compound copolymer (c);
30 to 75% by weight of a total (d) of a highly heat-resistant (meth)acrylic acid alkyl ester polymer (d-1) having a heat resistance of greater than 91° C. and a flow index (230° C., 3.8 kg) of 1 g/10 min to 5 g/10 min and a high-fluidity (meth)acrylic acid alkyl ester polymer (d-2) having a heat resistance of 91° C. or less and a flow index of greater than 5 g/10 minutes; and
0 to 5% by weight of a (meth)acrylic acid alkyl ester compound-aromatic vinyl compound-acid anhydride copolymer (e).
US Pat. No. 10,214,643

RECYCLED POLYETHYLENE TEREPHTHALATE COMPOSITIONS, FIBERS AND ARTICLES PRODUCED THEREFROM, AND METHODS FOR PRODUCING SAME

Columbia Insurance Compan...

1. An extruded polymer composition consisting essentially of polyethylene terephthalate polymer composition, wherein the polyethylene terephthalate polymer composition has about 25% by weight to about 100% by weight of homogenized deposit post-consumer polyethylene terephthalate and balance virgin polyethylene terephthalate, and wherein the homogenized deposit post-consumer polyethylene terephthalate comprises at least one impurity not present in virgin polyethylene terephthalate.
US Pat. No. 10,214,644

DARK POLYCARBONATE COMPOSITION

SABIC GLOBAL TECHNOLOGIES...

1. A flame-retardant polycarbonate blend, comprising:from about 30 wt % to about 80 wt % of a blend of a high molecular weight polycarbonate polymer having a Mw above 25,000 and a low molecular weight polycarbonate polymer having a Mw below 25,000 which when blended together have an average molecular weight from about 25,000 to about 30,000:
a polycarbonate-polysiloxane copolymer in an amount such that the blend contains from about 2 wt % to about 5 wt % of siloxane, wherein the polycarbonate-polysiloxane copolymer is different from the high molecular weight polycarbonate polymer and the low molecular weight polycarbonate polymer;
from about 0.01 wt % to about 0.05 wt % of a non-brominated and non-chlorinated flame retardant;
from about 1 wt % to about 10 wt % of titanium dioxide (TiO2); and
from about 0.2 wt % to about 2 wt % of carbon black;
wherein the ratio of TiO2 to carbon black is from about 4:1 to about 6:1; and wherein the blend has an L-value of 20 or less; meets CTI PLC 2 standards when measured according to ASTM D3638; has V0 performance at 0.08 mm thickness; and has 100% ductility at ?30° C.
US Pat. No. 10,213,368

ORAL CARE COMPOSITIONS

1. An oral care composition comprising:a. from 0.01% to 2% by weight of a stannous chloride source;
b. a thickening agent consisting of:
i) from 1% to 5% by weight carrageenan; and
ii) from 0.3% to 0.875% by weight xanthan gum;
c. at least 30% by weight of a total water content; and
d. from 20% to 80% of a humectant selected from the group consisting of glycerin, sorbitol, xylitol, butylene glycol, polyethylene glycol, propylene glycol, and combinations thereof;
e. a dental abrasive consisting of precipitated silica;
f. from 0.01% to 2% by weight of a fluoride ion source;
wherein the composition has a pH of greater than 4 and comprises less than 0.001% of a charged cellulose derivative having greater than 0.5 charged groups per sugar residue unit along the polysaccharide backbone;
wherein the composition has a Tip Viscosity of greater than 100 Pa·s after 4.5 months at 40° C.;
wherein the xanthan gum has a degree of substitution of less than 0.4 carboxylate groups per sugar residue.
US Pat. No. 10,213,880

SOLDER ALLOY, SOLDER PASTE, AND ELECTRONIC CIRCUIT BOARD

HARIMA CHEMICALS, INCORPO...

1. A solder alloy consisting essentially of:tin, silver, copper, bismuth, antimony, indium, and nickel, wherein
with respect to the total amount of the solder alloy,
the content ratio of the silver is 0.05 mass % or more and below 0.2 mass %;
the content ratio of the copper is 0.7 mass % or more and 1 mass % or less;
the content ratio of the bismuth is above 4.0 mass % and 10 mass % or less;
the content ratio of the antimony is 0.005 mass % or more and 8 mass % or less;
the content ratio of the indium is 0.005 mass % or more and 2 mass % or less;
the content ratio of the nickel is 0.003 mass % or more and 0.4 mass % or less; and
the content ratio of the tin is the remaining ratio and
the mass ratio (Bi/Ni) of the bismuth content with respect to the nickel content is 35 or more and 1500 or less.
US Pat. No. 10,215,672

BIOCOMPATIBLE METHOD OF FUNCTIONALISING SUBSTRATES WITH INERT SURFACES

KODE BIOTECH LIMITED, Au...

1. A method of localizing a functional moiety to the surface of a glass membrane by non-covalent interactions comprising the steps of:immersing the glass membrane in an aqueous dispersion of a construct of the structure F-S-L; and then
washing the glass membrane with an aqueous vehicle to provide the functionalised surface,
wherein F is the functional moiety, S is a spacer selected to provide a construct that is dispersible in water, and L is a diacyl- or dialkyl-glycerophospholipid.
US Pat. No. 10,213,369

ORAL COMPOSITIONS CONTAINING METAL IONS

Colgate-Palmolive Company...

1. An oral care composition comprising:(a) a stannous ion source;
(b) a zinc ion source;
(c) polyphosphate; and
(d) a thickening agent comprising:
(i) 1 to 3.5 weight % of polyvinylpyrrolidone,
(ii) 0.2 to 0.45 weight % of a polysaccharide gum, and
(iii) 0.05 to 0.3 weight % of carboxymethyl cellulose
wherein the weight % is by weight of the composition.
US Pat. No. 10,213,370

DENTIFRICE COMPOSITIONS WITH IMPROVED FLUORIDE STABILITY

1. A dentifrice composition comprising:(a) 45% to 75%, by weight of the composition, of water;
(b) 25% to 50%, by weight of the composition, of a calcium-containing abrasive;
(c) 0.0025% to 2%, by weight of the composition, of a fluoride ion source;
(d) greater than 0.3%, by weight of the composition, of alkaline metal carbonate;
(e) from 0.001% to 3%, by weight of the composition, of an alkali metal phosphate; and
(f) a pH greater than 9.
US Pat. No. 10,214,650

AQUEOUS COMPOSITE PARTICLE DISPERSION

ASAHI KASEI KABUSHIKI KAI...

1. An aqueous dispersion of composite particles comprising:an aqueous medium including water; and
composite particles dispersed in the aqueous medium,
wherein
the composite particles has a particle (A), and a polymer layer (B) encapsulating at least a part of a surface of the particle (A);
the particle (A) is at least any one particle of an inorganic solid particle, or a silica-encapsulated particle having a core particle and a silica layer encapsulating at least a part of a surface of the core particle; and
a zeta potential of the composite particles in the aqueous dispersion of composite particles at 60° C. is ?70 mV to ?160 mV at any pH in the range from 7 to 11.
US Pat. No. 10,213,627

ORAL COMPOSITIONS AND USES THEROF

Colgate-Palmolive Company...

1. An oral composition comprising an orally-acceptable carrier and an abrasive system consisting essentially of a precipitated silica abrasive, whereinthe precipitated silica abrasive has an average particle size of from 9 ?m to 13 ?m; and
an Einlehner hardness of from 6 to 9;
wherein the mean particle size of the precipitated silica abrasive is reduced by 16% to 20% after being applied to a hard surface in an oral cavity for from 30 seconds to 5 minutes;
wherein the precipitated silica abrasive is present in an amount from 10% to 20% weight of the composition;
wherein the precipitated silica abrasive has an oil absorption from 80 cc/100 g to 100 cc/100 g;
wherein the composition has a pellicle cleaning ratio of from 80 to 105 and has a radioactive dentin abrasion of less than 150;
wherein a 10% aqueous slurry consisting of the precipitated silica abrasive has a PCR/RDA ratio of from 0.7 to 0.9; and
wherein the only silica in the oral composition is the precipitated silica.
US Pat. No. 10,217,982

METHOD FOR PRODUCING LAMINATED POROUS FILM

SUMITOMO CHEMICAL COMPANY...

1. A method for producing a laminated porous film comprising a treated porous film and a heat-resistant layer,the method comprising treating an untreated porous film to provide the treated porous film, and
forming a heat-resistant layer comprising a filler on the surface of the treated porous film by applying a coating slurry comprising a solvent, a binder resin and the filler to the surface of the treated porous film and then removing the solvent,
wherein the coating slurry is prepared so as to have a contact angle of 75° or more with the untreated porous film to prevent the coating slurry from penetrating into the treated porous film, and the viscosity of the coating slurry is in the range of not less than 300 cP and not more than 10000 cP.
US Pat. No. 10,213,372

METHOD FOR SIMULTANEOUSLY AND PERMANENTLY RESHAPING AND COLORING KERATIN FIBERS

1. A method for permanently reshaping and changing the color of keratinic fibers, in a single process, with the method comprising the following method steps in the indicated sequence:a) styling of keratinic fibers using styling aids,
b) application of an aqueous composition (M1) including at least one keratin-reducing compound selected from the group consisting of thioglycolic acid, thiolactic acid, cysteine, and salts thereof and present in a total quantity of 10 to 15 wt % based on the total weight of the aqueous composition (M1), at least one alkalizing agent that is ammonium hydrogen carbonate and/or ammonium hydroxide, and present in a total quantity of 1.5 to 7 wt % based on the total weight of the aqueous composition (M1), and at least one surfactant selected from the group consisting of alkyl (ether) sulfates, alkyl betaines, alkyl polyglucosides, and nonionic surfactants, and present in a total quantity of 3.0 to 7.0 wt % based on the total weight of the aqueous composition (M1), from an applicator as a foam onto the keratinic fibers located on the styling aids and leaving this aqueous composition (M1) on the keratinic fibers located on the styling aids for a period of 5 to 50 minutes,
c) rinsing and, optionally, drying of the keratinic fibers located on the styling aids,
d) application of an aqueous foam composition (M2) including at least one oxidation dye precursor present in an amount of from 0.5 to 3 wt % with respect to the total weight of the aqueous foam composition (M2), at least one oxidizing agent that is hydrogen peroxide and is present in a total quantity of 1.5 to 7.5 wt % based on the total weight of the aqueous foam composition (M2), at least one alkalizing agent that is monoethanolamine and that is present in an amount of from 2.0 to 6.0 wt % with respect to the total weight of the aqueous foam composition (M2), and at least one surfactant from an applicator onto the keratinic fibers located on the styling aids and leaving this aqueous foam composition (M2) on the keratinic fibers located on the styling aids for a period of 10 to 15 minutes,
e) removal of the styling aids from the keratinic fibers,
f) distribution of the aqueous foam composition (M2) applied in step (d) remaining on the keratinic fibers and/or repeated application of the aqueous foam composition (M2) and leaving this aqueous foam composition (M2) on the keratinic fibers for a period of 15 to 30 minutes,
g) rinsing of the keratinic fibers, and
h) optionally, application of a post-treatment agent to the keratinic fibers
wherein the aqueous foam composition (M2) used in step (d) includes, as a surfactant, at least one alkyl betaine, at least one alkyl polyglucoside, at least one nonionic surfactant having an HLB value of greater than 10, and at least one anionic surfactant,
wherein the aqueous foam composition (M2) used in method step (d) includes the at least one surfactant in total quantity of 20 to 27 wt % with respect to the total weight of the aqueous foam composition (M2), and
wherein each foam of step (b) and (d) is independently a colloid-chemical system composed of gas-filled cells that are bordered by a fluid, semifluid, or highly viscous cell web.
US Pat. No. 10,214,652

ALUMINUM-COPPER COMPOSITE SEMI-FINISHED PRODUCT FOR ELECTRICAL ENGINEERING AND METHOD FOR PRODUCING SAME

DODUCO SOLUTIONS GMBH, P...

1. A method for producing a semi-finished product for electrical engineering comprising the following steps:producing a composite from an aluminium sheet and a copper sheet, wherein the aluminium sheet and the copper sheet are joined by rolling;
applying an acrylate-based lacquer to the composite, the acrylate-based lacquer containing acrylate monomers and at least one photoinitiator; and
polymerizing the acrylate monomers with radiation.
US Pat. No. 10,217,983

CROSS-LINKED COMPOUND PARTICLE AND SECONDARY BATTERY INCLUDING THE SAME

LG Chem, Ltd., (KR)

1. A compound particle comprised in an electrolyte for a lithium-ion polymer battery, wherein the compound particle comprises:a monomer and a polymerization initiator, as a core; and
a film as a shell,
wherein the monomer is acrylonitrile,
wherein the film comprises a thermoplastic resin that is polyacrylonitrile (PAN), and
wherein the polymerization initiator is a photoinitiator, a thermoinitiator, a radiation initiator or a mixture thereof.
US Pat. No. 10,213,373

CHROMOPHORE COMBINATIONS FOR BIOPHOTONIC USES

KLOX TECHNOLOGIES, INC., ...

1. A biophotonic composition for topical application to a target tissue, the biophotonic composition comprising a first xanthene dye and at least one other xanthene dye, wherein the first xanthene dye is Eosin Y and is present in the biophotonic composition at a concentration of between about 0.5 mg/mL and about 1 mg/mL; and wherein the at least one other xanthene dye is present in the biophotonic composition at a concentration of between about 0.001% and about 0.5% per weight of the biophotonic composition.
US Pat. No. 10,213,374

ORAL CARE COMPOSITIONS AND METHODS OF USE

Colgate-Palmolive Company...

1. A naringin:Zn complex, wherein said naringin:Zn complex has a 2:1 naringin to zinc molar ratio.
US Pat. No. 10,214,654

METHOD FOR FORMING MULTILAYER COATING FILM

NIPPON PAINT AUTOMOTIVE C...

1. A method for forming a multilayer coating film comprising the steps of:(1) applying a first water-based base coating composition on a surface of a coating material to form an uncured first water-based base coating film,
(2) applying a second water-based base coating composition on the uncured first water-based base coating film to form an uncured second water-based base coating film,
(3) applying a clear coating composition on the uncured second water-based base coating film to form an uncured clear coating film, and
(4) simultaneously heating and curing the uncured first water-based base coating film, the uncured second water-based base coating film and the uncured clear coating film formed in the steps (1), (2) and (3) to form a multilayer coating film, wherein:
the first water-based base coating composition comprises an acrylic emulsion resin, a curing agent and a hydrophilic associated type viscosity agent, wherein the curing agent is a melamine resin, and the hydrophilic associated type viscosity agent is a polyamide type viscosity agent; and
the second water-based base coating composition comprises a film forming resin, and the film forming resin comprises:
an acrylic emulsion resin (A) comprising a single layered acrylic emulsion resin (a) and a core-shell type acrylic emulsion resin (b) and each of (a) and (b) obtained by emulsion polymerization of a monomer mixture containing a (meth)acrylic acid alkyl ester (i), an ethylenically unsaturated monomer having an acid group (ii) and an ethylenically unsaturated monomer having a hydroxyl group (iii),
a water soluble acrylic resin (B) prepared by co-polymerization of a hydroxyl group-containing monomer and another monomer,
wherein the another monomer is at least one selected from the group consisting of a carboxyl group-containing monomer, a dicarboxylic acid monoester monomer, a (meth)acrylate alkylester monomer, an alicyclic group-containing monomer, a (meth)acrylic acid aminoalkyl ester monomer, a (meth)acrylic acid aminoalkyl amide monomer, an amido group-containing monomer, a vinyl cyanide monomer, a saturated aliphatic carboxylic acid vinyl ester monomer and a styrene monomer, and
a water soluble polyester resin (C) prepared by polycondensation reaction of a polyalcohol with a polybasic acid or anhydride thereof,
wherein the polyalcohol is at least one selected from the group consisting of ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, neopentylglycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 1,5-pentanediol, 1,6-hexanediol, hydrogenated bisphenol A, hydroxyalkylated bisphenol A, 1,4-cyclohexanedimethanol, 2,2-dimethyl-3-hydroxypropyl-2,2-dimethyl-3-hydroxypropionate, 2,2,4-trimethyl-1,3-pentanediol, N,N-bis-(2-hydroxyethyl) dimethyl hydantoin, polytetramethylene ether glycol, polycaprolactone polyol, glycerin, sorbitol, trimethylol ethane, trimethylol propane, trimethylol butane, hexanetriol, pentaerythritol, dipentaerythritol and tris-(hydroxyethyl) isocyanate, and
wherein the polybasic acid or anhydride thereof is at least one selected from the group consisting of phthalic acid, phthalic anhydrite, tetrahydrophthalic acid, tetrahydrophthalic anhydrite, hexahydrophthalic acid, hexahydrophthalic anhydrite, methyl tetrahydrophthalic acid, methyl tetrahydrophthalic anhydrite, himic anhydride, trimellitic acid, trimellitic anhydride, pyromellitic acid, pyromellitic anhydride, isophthalic acid, terephthalic acid, maleic acid, maleic anhydride, fumaric acid, itaconic acid, adipic acid, azelaic acid, sebacic acid, succinic acid, succinic anhydride, lactic acid, dodecenyl succinic acid, dodecenyl succinic anhydride, cyclohexane-1,4-dicarboxylic acid and endo anhydride; andwherein,a rate represented by the following formula:
(A)/(A+B+C)
wherein (A) is a resin solid content by mass of the acrylic emulsion resin (A), and (A+B+C) is a total resin solid content by mass of the acrylic emulsion resin (A), the water soluble acrylic resin (B) and the water soluble polyester resin (C),is from 40% to 60% expressed in percentage.
US Pat. No. 10,213,119

SYSTEMS AND METHODS FOR DETERMINATION OF BLOOD FLOW CHARACTERISTICS AND PATHOLOGIES THROUGH MODELING OF MYOCARDIAL BLOOD SUPPLY

HeartFlow, Inc., Redwood...

1. A computer-implemented method of building a patient-specific anatomic model, the method comprising:receiving a vascular model associated with one or more individuals;
receiving a tissue model associated with the one or more individuals;
calculating a first perfusion value using the vascular model and the tissue model;
determining, using a fluid dynamics computation, a first vascular pathology of the vascular model used for the calculation of the first perfusion value;
receiving, for a given patient, a patient-specific observed perfusion value;
deforming a stored vascular model based on the first vascular pathology and the received patient-specific observed perfusion value;
calculating a second perfusion value using the deformed vascular model; and
generating a patient-specific vascular model based on a comparison of for which the second perfusion value matches the patient-specific observed perfusion value and the deformed vascular model.
US Pat. No. 10,213,375

COSMETIC OR DERMATOLOGICAL COMPOSITIONS COMBINING COSMETIQUES RETINALDEHYDE AND GLYCYLGLYCINE OLEAMIDE AND THE COSMETIC OR DERMATOLOGICAL USES THEREOF

PIERRE FABRE DERMO-COSMET...

1. A method for combating ageing of the skin by increasing the physiological stores of vitamin A in the skin, said method comprising:applying on the skin a therapeutically effective amount of a cosmetic or dermatological composition comprising as an active ingredient retinaldehyde and glycylglycine oleamide and at least one cosmetically or dermatologically acceptable carrier.