US Pat. No. 10,137,474

HIGH VISCOSITY FLUID DISPENSING SYSTEM

The Boeing Company, Chic...

1. A method for depositing a fluid over an interface, the method comprising:moving, by a dispensing device, the fluid within a chamber in a housing towards an exit of the chamber such that the fluid is dispensed through the exit of the chamber, wherein the chamber is configured to increase a tendency of the fluid to flow within the chamber;
receiving the fluid from the exit of the chamber at an input of a nozzle located at a first end of a body of the nozzle;
moving the fluid from the input through an arrangement of a plurality of channels located within the body such that the fluid exits the plurality of channels at an output of the nozzle located at a second end of the body, including:
moving the fluid through a center channel located along a center axis that extends through the first end and the second end of the body of the nozzle, wherein the cross-sectional diameter of the center channel varies along a length that extends along the center axis; and
moving the fluid through outer channels located away from the center axis around the center channel, wherein the cross-sectional diameter of each of the outer channels remains substantially constant along the center axis;
controlling a flow of the fluid through the plurality of channels by a configuration of the plurality of channels, wherein the configuration comprises a diameter profile that includes the cross-sectional diameter for each of the plurality of channels; and
depositing the fluid that exits the output of the nozzle over the interface to form a deposition having a desired shape.

US Pat. No. 10,137,281

CATHETER FOR TREATMENT OF SINUSITIS

Tsukada Medical Research ...

1. A catheter for treatment of sinusitis comprising:an anterior nasal aperture balloon;
an anterior nasal aperture balloon air supply lumen for inflating the anterior nasal aperture balloon;
a posterior nasal aperture balloon;
a posterior nasal aperture balloon air supply lumen for inflating the posterior nasal aperture balloon;
a drainage lumen having an opening between the anterior nasal aperture balloon and the posterior nasal aperture balloon;
a drainage catheter comprising the anterior nasal aperture balloon air supply lumen and the drainage lumen therein;
a posterior nasal aperture balloon catheter comprising the posterior nasal aperture balloon air supply lumen therein; and
an external air communication lumen having an opening on a distal side from the posterior nasal aperture balloon is further provided in the posterior nasal aperture balloon catheter,
wherein the catheter comprising the external air communication lumen is formed of silicone rubber,
wherein the drainage catheter and the posterior nasal aperture balloon catheter are arranged in a side-by-side configuration,
wherein a distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is adjustable, and
wherein adjustment of the distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is realized by an internal space having a circular section formed in the anterior nasal aperture balloon through which the posterior nasal aperture balloon catheter passes, and at least one annular sealing rib formed on a wall surface which surrounds the internal space, and the at least one annular sealing rib is configured to seal an annular gap between an outer surface of the posterior nasal aperture balloon catheter and the wall surface such that liquid does not pass through the annular gap between the outer surface and the wall surface.

US Pat. No. 10,137,279

CATHETER GUIDE AND METHOD FOR UTILIZING THE SAME

WILLIAM BEAUMONT HOSPITAL...

1. A catheter guide comprising:a first conduit for guiding a catheter, wherein the first conduit includes a tube-shaped body having a proximal end and a distal end, and wherein the distal end of the tube-shaped body is sized and configured to be inserted into a urethra;
a second conduit connected to an outer surface of the first conduit, wherein a passage extending through the first conduit is fluidly-connected to a passage extending through the second conduit;
a shield member, wherein the shield member includes an inner surface and an outer surface, wherein the shield member is connected to the outer surface of the first conduit, and wherein the distal end of the tube-shaped body of the first conduit extends through the shield member and beyond at least part of the inner surface of the shield member;
a grasping member that extends radially outwardly from and is integrally connected to the outer surface of the first conduit, wherein the grasping member is angularly offset from the second conduit at a first angle; and
a third conduit connected to the outer surface of the first conduit, wherein the passage extending through the first conduit is fluidly-connected to a passage extending through the third conduit, wherein the grasping member is angularly offset from the third conduit at a second angle, and wherein the second conduit is angularly offset from the third conduit at a third angle,
wherein the first conduit of the catheter guide includes one or more weakened zones, wherein at least one first weakened zone of the one or more weakened zones longitudinally extends along the length of the first conduit.

US Pat. No. 10,137,278

CANNULA STABILIZATION DEVICE

1. A cannula stabilization device comprising:a bearing platform;
a tubing holder located on a first end of the bearing platform;
a tubing holder located on a second end of the bearing platform opposite the first end, wherein each tubing holder is configured to secure and route continuous tubing, and wherein the tubing is configured to intersect the bearing platform only at each tubing holder;
a rotational joint fixedly attached to the bearing platform on a bottom side of the bearing platform; and
a helmet releasably attachable to the rotational joint;
wherein the helmet and the bearing platform are independently rotatable around a common rotational axis when the helmet is attached to the rotational joint.

US Pat. No. 10,137,277

CIRCADIAN-FRIENDLY LED LIGHT SOURCE

Soraa, Inc., Fremont, CA...

1. A light emitter comprising:one or more LEDs configured to emit LED light, said one or more LEDs comprising at least a violet pump LED configured to emit a pump light with a peak wavelength around 405 nm;
at least one phosphor configured to emit converted light by converting a fraction of said pump light; and
wherein said light emitter emits an emitted light formed by a combination of a fraction of said LED light and said converted light, said emitted light having a spectral power distribution (SPD), said SPD has a first power from 350 nm to 850 nm and a second power from 400 nm to about 440 nm, wherein said second power is at least 25% of said first power, and wherein said SPD has a CRI greater than 80 and an R9 greater than 0.

US Pat. No. 10,137,276

SYSTEM AND METHOD FOR SLEEP SESSION MANAGEMENT BASED ON SLOW WAVE SLEEP ACTIVITY IN A SUBJECT

Koninklijke Philips N.V.,...

1. A system configured to manage a sleep session of a subject, the system comprising:one or more sensory stimulators configured to provide sensory stimuli to the subject;
one or more sensors configured to generate output signals conveying information related to a current sleep stage of the subject during the sleep session; and
one or more processors configured by machine-readable instructions to:
determine a dissipation threshold level for triggering a sensory waking stimulus;
obtain, during the sleep session, the output signals from the one or more sensors, at least some of the output signals being related to slow wave activity in the subject;
monitor, during the sleep session, the slow wave activity based on the output signals;
determine, based on the monitoring of the slow wave activity, a rate of change in the slow wave activity over time with respect to the sleep session;
determine a sleep pressure dissipation level of the subject based on the rate of change in the slow wave activity, the sleep pressure dissipation level being a metric indicating a level of dissipation with respect to sleep pressure of the subject, the sleep pressure indicating the subject's remaining need for sleep; and
responsive to the sleep pressure dissipation level breaching the dissipation threshold level, control the one or more sensory stimulators to generate the sensory waking stimulus to cause the subject to wake from the sleep session.

US Pat. No. 10,137,275

OXYGEN CONCENTRATOR FOR HIGH PRESSURE OXYGEN DELIVERY WITH OXYGEN CIRCULATION LOOP AND IMPROVED PORTABILITY

BreatheTechnologies, Inc....

1. A portable apparatus for concentrating and delivering high pressure oxygen to a ventilator, the apparatus comprising:an enclosure defining an air inlet, an oxygen outlet and a flow pathway extending between the air inlet and the oxygen outlet;
a high pressure compressor disposed within the enclosure and integrated into the flow pathway, the high pressure compressor having a compressor inlet fluidly coupled to the air inlet, and a compressor outlet;
an adsorbent sieve bed disposed within the enclosure and integrated into the flow pathway, the sieve bed having a sieve bed inlet fluidly coupled to the compressor outlet of the high pressure compressor, and a sieve bed outlet, with the sieve bed being operative to remove nitrogen from air flowing therethrough;
a high pressure accumulator disposed within the enclosure and integrated into the flow pathway, the high pressure accumulator having an accumulator inlet fluidly coupled to the sieve bed outlet of the adsorbent sieve bed, and an accumulator outlet fluidly coupled to the oxygen outlet;
a first valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the sieve bed outlet of the sieve bed and the accumulator inlet of the accumulator, the first valve being operative to prevent flow from the high pressure accumulator to the sieve bed;
a third valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the air inlet and the compressor inlet of the high pressure compressor; and
an oxygen circulation loop having a first end fluidly coupled to the flow pathway between the third valve and the compressor inlet of the high pressure compressor, and a second end fluidly coupled to the flow pathway between the sieve bed outlet of the sieve bed and the first valve;
the oxygen circulation loop being operative to permit oxygen enriched gas to be circulated through the sieve bed, with the third valve being operative to prevent flow of the oxygen enriched gas to ambient via the air inlet;
the high pressure compressor, the sieve bed and the high pressure accumulator being sized and configured to allow the apparatus to operate at a pressure level in the range of from about 40-80 psi.

US Pat. No. 10,137,274

PATIENT INTERFACES

1. A patient interface comprising:a mask assembly configured to be coupled with an elbow assembly for delivering a pressurized gas to a patient;
the elbow assembly comprising:
a first leg configured to connect to a source of the pressurized gas at a first end of the elbow assembly; and
a second leg configured to swivelably connect to the mask assembly, the second leg comprising:
a second end of the elbow assembly configured to insertably interface with the mask assembly;
an outer conduit and an inner conduit fixed within the outer conduit, a first tubular section of the outer conduit disposed radially outward of a second tubular section of the inner conduit, the inner conduit and the outer conduit extending towards the second end of the elbow assembly from a front wall of the outer conduit, a distal end of the outer conduit disposed beyond a distal portion of the second tubular section of the inner conduit in an axial direction such that the distal portion of the second tubular section is disposed within a straight section of the second leg;
a first flow path defined between the inner conduit and the outer conduit, the first flow path accommodating a first flow of gases in a first direction;
a second flow path defined within the inner conduit, the second flow path accommodating a second flow of gases in a second direction, the first direction being directly opposite the second direction in at least a portion of the second leg; and
a diffuser comprising a plurality of exhaust vents in the front wall of the outer conduit.

US Pat. No. 10,137,273

PATIENT INTERFACES

1. A patient interface for use as part of a system for delivering a supply of gases to a patient comprising:a hollow body configured to be disposed on the patient's face in use and configured to deliver gases to the patient, said hollow body comprising an aperture extending from an inside of the hollow body to an outside of said hollow body; and
an elbow connector comprising a first end configured to be connected to a gas supply conduit, a second end configured to be swivelably connected to said aperture of said hollow body, and an exhaust port positioned between said first end and said second end, said exhaust port comprising a plurality of outlet vent holes extending through an outer wall of the elbow connector, and at least one wall at least partially defining an exhaust passage and extending from said exhaust port toward said second end, and said at least one wall being interposed between said exhaust passage and a delivery passage extending from said first end of said elbow connector to said second end of said elbow connector such that incoming gases are separated from said exhaust passage by said at least one wall, wherein said wall forms an enclosed perimeter such that a space within the wall is separated from a space that completely surrounds the wall, and wherein the wall extends in a direction aligned with the second end of the elbow connector;
wherein said at least one wall is rigid and fixed in position inside said elbow connector.

US Pat. No. 10,137,272

DEVICE FOR POSITIONING A PATIENT INTERFACE

Loweenstein Medical Techn...

1. An adjusting device for a patient interface that is fixed on the head of a patient by a head harness, wherein the device comprises at least one harness receiving element, a support body for supporting the patient interface in a region of the forehead of the patient and a single spring element which contacts the support body at least in a compressed state, wherein a tightening force of the head harness is transmitted to the spring element by the at least one harness receiving element such that the spring element is at least partially compressed to thereby exert a force which presses the support body against the forehead of the patient, and wherein the support body engages at least in part in a horizontal receiving element of a mask body and the spring element in a mounted state is present in part in the receiving element and in part in a guide to thereby be covered over its entire length.

US Pat. No. 10,137,271

NASAL INTERFACE

1. A nasal interface for use in a system for providing a flow of respiratory gases to a user, the nasal interface comprising:a body made from a pliable first material, the body comprising an inlet configured to receive a flow of gases and at least one nasal outlet, the at least one nasal outlet comprising a tubular structure configured to interface with a user's nostril, the at least one nasal outlet being fluidly connected to the inlet, wherein at least one plastically deformable member is attached to or integrally formed with the body, the at least one plastically deformable member having an elastic limit less than the elastic limit of the pliable first material; and
a flow restrictor comprising a member coupled to the body in a fixed position, the flow restrictor blocking a center of the flow of gases through the body and defining a gradually reducing cross sectional flow area such that all flow into and through the body passes through and is thereby restricted by the flow restrictor, wherein the flow restrictor is a dominant flow restriction of all gases flow in the system.

US Pat. No. 10,137,270

CUSHION TO FRAME ASSEMBLY MECHANISM

ResMed Limited, Bella Vi...

1. A mask assembly for treatment of sleep disorder breathing by delivering a flow of pressurized gas to a patient, the mask assembly comprising:a first frame including a first wall that at least partially delimits a breathing chamber, a second wall surrounding an opening through the first wall and defining a first substantially cylindrical surface surrounding the opening and defining a central axis, the second wall extending from the first wall, the opening being configured to allow the flow of pressurized gas to the breathing chamber;
a second frame including a third wall that is cylindrical and defines a second substantially cylindrical surface, a fourth wall, a member extending toward a forehead support and two headgear attachment locations, the third wall extending away from the fourth wall, the second substantially cylindrical surface at least partially overlapping with and passing completely around the first substantially cylindrical surface, and the second frame being configured to removably interlock with the first frame proximate the opening when the first frame and the second frame are moved towards one another along the central axis; and
a cushion molded to the first frame and including a side wall and a membrane adapted to seal around a patient's nose, the membrane being connected to the side wall at an outer periphery of the membrane and being unconnected at an inner periphery of the membrane; wherein
the membrane is on an opposite side of the first frame with respect to the opening,
the first frame comprises a first material and the cushion comprises a second material that is more flexible than the first material and the first wall and the second wall comprise the first material.

US Pat. No. 10,137,269

CUSHION-TO-FRAME COMPONENT FOR AN INTERFACING STRUCTURE

RESMED LIMITED, Bella Vi...

1. An interfacing structure for a mask system, comprising:a cushion component adapted to contact the patient's face in use; and
a cushion-to-frame component provided to the cushion component, the cushion-to-frame component structured to secure the cushion component to a mask frame of the mask system,
the cushion-to-frame component including a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame,
wherein the cushion side includes a platform including an inner flange and an outer flange provided to opposing ends of the platform and an engagement surface between the inner flange and the outer flange to engage the cushion component, and
wherein the engagement surface is non-linear along its width and includes incline portions, decline portions, and flat portions along its width.

US Pat. No. 10,137,268

SYSTEM AND METHOD FOR SECURING A BREATHING GAS DELIVERY HOSE

CPAP Miracle LLC, Beachw...

1. A device comprising:a substantially rigid, elongated contiguous, tubular support member comprised of a tube wall having a first distal end, a second distal end, and a centralized living hinge biasing portion, integrated in the tube wall and comprised of a series of spaced apart slits in the tube wall, the living hinge, configured to bias arcuate movement between the first distal end and the second distal end, and wherein
the living hinge has an axial length smaller than axial lengths of the first and second distal ends,
a bias of the living hinge is configured to be adjustable while maintaining a fixed distance between the first and second distal ends, and
the bias of the living hinge corresponds to a position of an outer tube disposed circumferentially along a surface of the tube so as to be slide-able relative to the biasing portion;
a generally planar, rigid base configured to receive an associated pillow on an upper surface thereof so as to secure the first distal end so that the support member extends from a surface of the base to hold the first distal end in a generally vertical position relative to the second distal end when a radial force is applied to the second distal end during flexure of the living hinge;
a mount comprised of first and second coaxial, biased C-clips secured to the second distal end, the mount configured to snap fit an associated tube thereto with substantially unrestricted fluid flow therethrough; and
a mount support, formed from a cutaway portion of the tube wall, extending radially outwardly from the tube.

US Pat. No. 10,137,267

TRACHEOSTOMY TUBES

SMITHS MEDICAL INTERNATIO...

1. A tracheostomy tube having a shaft with a length, a patient end, a machine end and a fenestrated region locating substantially midway along the length and spaced from the machine end and the patient end including at least one opening at a location adapted to lie within the trachea, characterized in that the shaft is formed of a first material that is relatively soft and that the fenestrated region of the tube is formed only by a plate that includes the at least one opening, the plate formed of a second material that is stiffer than the first material to increase the overall stiffness of the shaft at the fenestrated region such that the portion of the shaft between the patient end of the tube and the patient end of the plate is more flexible than the fenestrated portion.

US Pat. No. 10,137,266

PATIENT-VENTILATOR DYSSYNCHRONY DETECTION

KONINKLIJKE PHILIPS N.V.,...

1. A method of detecting dyssynchrony between a patient and a pressure support system, comprising:receiving patient flow data representing a patient flow waveform, the patient flow waveform representing a flow of gas provided to the patient by the pressure support system;
obtaining an I/E state signal indicating whether a current respiratory phase of the patient is inspiratory or expiratory, the I/E state signal being in binary form and having only a first binary state and a second binary state, the first binary state indicating that the current respiratory phase is inspiratory and the second binary state indicating that the current respiratory phase is expiratory; and
analyzing both the patient flow data and the I/E state signal for a breath to determine whether at least one of a number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal and declaring a dyssynchrony for the breath and outputting a dyssynchrony indicator if it is determined that at least one of the number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal, wherein the dyssynchrony is a condition where a respiratory drive of the patient is out of sync with breaths being generated by the pressure support system, wherein the number of predetermined criterion includes all of; (i) a number of volume qualified flow slope reversals in the patient flow data for the breath exceeding a predetermined number; (ii) an incremented tidal volume during at least a portion of an expiratory phase of the breath as indicated by the I/E state signal exceeding a predetermined positive value; (iii) an absolute value of a tidal volume during the breath exceeds a predetermined value; and (iv) a tidal volume during an inspiratory phase of the breath as indicated by the I/E state is less than a predetermined negative value.

US Pat. No. 10,137,265

SYSTEMS AND METHODS FOR WIRELESS FEEDBACK DURING VENTILATION

ZOLL MEDICAL CORPORATION,...

1. A system for providing feedback on delivery of cardiopulmonary resuscitation (CPR), the system comprising:a manual patient ventilation unit defining an airflow path, the unit arranged so that when the unit is applied to a patient, the airflow path is in fluid communication with the patients airway, the patient ventilation unit comprising:
a ventilation bag configured to enable manual ventilation of the patient by a rescuer;
at least one first sensor in the airflow path positioned to sense the presence of ventilation airflow and measure a gas flow rate in the airflow path; and
at least one second sensor in the airflow path positioned to sense gas pressure in the airflow path;
at least one chest compression sensor configured to detect and measure compression information based on chest compressions applied to the patient; and
a feedback unit separate from the manual patient ventilation unit comprising a processor arranged to:
wirelessly receive data generated by the at least one first sensor and the at least one second sensor;
determine one or more ventilation quality parameters based at least in part on a gas flow volume calculated based on the sensed gas flow rate and gas pressures;
receive compression data generated by the at least one chest compression sensor;
determine one or more chest compression parameters based at least in part on the measured compression information; and
provide both ventilation feedback and chest compression feedback to a rescuer, the ventilation feedback comprising the one or more ventilation quality parameters and instructions for performing ventilations based upon a comparison of the ventilation quality parameters with a ventilation protocol comprising ranges of predetermined acceptable values for administering ventilations to the patient and the chest compression feedback comprising the one or more chest compression parameters and instructions for performing chest compressions based upon a comparison of the chest compression parameters with a chest compression protocol comprising ranges of predetermined acceptable values for administering chest compressions to the patient,
wherein the ventilation quality parameters comprise one or more of tidal volume, minute volume, end-inspiratory pressure, and maximum ventilation pressure.

US Pat. No. 10,137,264

RESPIRATORY ASSISTANCE APPARATUS

1. A head-mounted respiratory assistance apparatus configured to provide a respiratory gases stream to a user, comprising:a main body securable to the head of a user;
a blower unit provided on the main body having a gases inlet to receive a supply of gases from the surrounding atmosphere and which is operable to generate a pressurised gases stream at a gases outlet, wherein the blower unit comprises a casing and wherein the gases outlet extends radially outward from a center of the casing; and
a patient interface provided on the main body having a gases inlet which is fluidly connected via a gases flow path to the gases outlet of the blower unit and which is configured to deliver the pressurised gases to the user's nose and/or mouth via one or more gases outlets,
wherein the gases flow path from the gases inlet of the blower unit to the gases outlet(s) of the patient interface is substantially sealed such that there is zero bias flow along the gases flow path, and
wherein the blower unit comprises a lightweight shroudless impeller, wherein the impeller comprises a plurality of separated impeller blades extending outward from a central hub of the impeller, and a motor with a rotatable drive shaft that is configured to rotate the impeller.

US Pat. No. 10,137,263

APPARATUS AND METHOD FOR MONITORING AN AIRWAY DEVICE SUCH AS AN ENDOTRACHEAL TUBE

Indian Ocean Medical Inc....

1. A method of detecting a leak of fluid from an inflatable airway device in a closed volume pressure system, the method comprising:periodically receiving a pressure value for the inflatable airway device from a pressure sensor in a pressure control and monitoring apparatus in the closed volume pressure system;
in a processor of the pressure control and monitoring apparatus, comparing the received pressure value with a setpoint value to determine a difference between the received pressure value and the setpoint value;
calculating in the processor if the difference is within a predefined tolerance band of the setpoint value;
calculating in the processor a rate of change of volume as a number of steps of a stepper motor in the closed volume pressure system required to correct the difference between the received pressure value and the setpoint value;
if the received pressure value is higher than the predefined tolerance band, setting the number of steps of the stepper motor as negative, if the received pressure value is lower than the predefined tolerance band, setting the number of steps of the stepper motor as positive, and driving the stepper motor the number of steps required to correct the difference between the received pressure value and the setpoint value;
calculating in the processor a statistical average of the rate of change of volume calculated using the received pressure value and a predetermined number of previously received pressure values to indicate whether significant changes have been necessary over a preceding time interval to increase pressure to the setpoint value;
determining if the statistical average is greater or lower than a threshold value, wherein the threshold value is a minimum average value that is indicative of an ineffective operation of pressure regulation in response to pressure reduction arising during normal usage of a patient and the minimum average value represents an average value for a breathing cycle, including inflation, deflation, and static steps, over a predetermined number of seconds; and
if the statistical average is greater than the threshold value, activating an alarm in the pressure control and monitoring apparatus to indicate a leak of fluid from the airway device.

US Pat. No. 10,137,262

SYNCHRONIZING MECHANICAL IN-EXSUFFLATION AND DIAPHRAGMATIC PACING

KONINKLIJKE PHILIPS N.V.,...

1. A system for synchronizing machine-induced inexsufflation with a diaphragmatic pacing of a subject, the system comprising;a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
one or more sensors configured to generate one or more output signals conveying information related to one or both of
i) one or more gas parameters of a flow of breathable gas being breathed by the subject and/or
ii) one or more respiratory parameters of the subject; and
one or more processors configured to execute computer program modules, the computer program modules comprising:
a configuration module configured to obtain one or more configurable operational settings of the diaphragmatic pacing of the subject;
a detection module configured to detect onsets of inhalations of the subject such that, for a first respiratory cycle, the detection module detects an onset of a first inhalation of the subject based on the one or more output signals, wherein the first inhalation is included in the first respiratory cycle;
a target module configured to determine a target parameter for machine-induced inexsufflation during respiratory cycles such that, responsive to detection of the onset of the first inhalation, the target module determines the target parameter for machine-induced inexsufflation during a second respiratory cycle such that the machine-induced inexsufflation occurs in synchrony with the diaphragmatic pacing of the subject, wherein the second respiratory cycle is subsequent to the first respiratory cycle, and wherein the target parameter corresponds to an onset of inhalation during the second respiratory cycle or an onset of exhalation during the second respiratory cycle; and
a control module configured to control the pressure generator to inexsufflate the subject such that during the second respiratory cycle the control module controls the pressure generator to inexsufflate the subject in accordance with the target parameter for machine-induced inexsufflation, wherein:
inexsufflating the subject comprises controlling the pressure generator to generate a pressure cycle providing a positive pressure during a first time period, a negative pressure during a second time period, and a pause in pressure generation during a third time period, wherein the third time period occurs subsequent to the second time period and the second time period occurs subsequent to the first time period; and
at least two of the first, second, or third time periods are adjusted based on the target parameter in one or more subsequent pressure cycles to enhance synchronization of the machine-induced inexsufflation with the diaphragmatic pacing over multiple pressure or respiratory cycles.

US Pat. No. 10,137,261

INHALATOR

LK INVESTMENT APS, Humle...

1. An inhalator comprising a housing with at least a first compartment and a second compartment, and including one or more substances, and a release device, said second compartment including at least one air entry port, said inhalator having a first proximal end of said first compartment and a second proximal end of said second compartment and a first distal end of the first compartment, a second distal end distal of the second compartment, the at least one entry port is at the second distal end, an inhalation part being at said second proximal end, said first compartment being for storing at least one substance and including in an inoperative state of said inhalator a plurality of sealing bodies arranged in a neighboring relationship, without the release device inserted into the housing, wherein being proximal is closest to a mouth of a user and being distal is furthest away from the mouth of said user;wherein at least one pair of neighboring sealing bodies defines at least in part a sealed chamber for containing a substance, said at least one pair of neighboring sealing bodies being movable together with said at least one substance from said first compartment into said second compartment to define an operative state of said inhalator;
said operative state of the inhalator being a state;
wherein said one or more substances are contained and are allowed to mix and blend in said second compartment;
the release device is in the first compartment, and
air entering through said at least one air entry port obtains at least a part of said at least one substance contained in said second compartment and is inhaled through said inhalation part while the release device is in the first compartment; and
wherein said release device is for moving at least one of the sealing bodies from the first compartment to the second compartment when being inserted into the first compartment from the first distal end, and is configured to allow said air to flow to said at least one air entry port in the operative state, and the second compartment is located between the inhalation part and the first compartment.

US Pat. No. 10,137,260

NEBULIZER KIT AND NEBULIZER

OMRON HEALTHCARE CO., LTD...

1. A nebulizer kit comprising:an external air introduction tube defining an external air introduction path that introduces external air into the nebulizer kit;
an atomization portion that generates aerosol using compressed air from a compressed air tube unit, the atomization portion including a conically shaped liquid aspiration tube forming body that has an opening formed at both ends thereof, the atomization portion being provided at a center position within the external air introduction tube such that the external air introduction tube surrounds at least an upper portion of the atomization portion; and
a case body surrounding the external air introduction tube and defining an aerosol carrier path that communicates with an aerosol discharge port, the aerosol carrier path having at least a first region and a second region, the first region being located closer to the aerosol discharge port, and the second region being located opposite to the first region, wherein:
the case body includes an aerosol stream changing portion being provided in the second region of the aerosol carrier path, the atomization portion being located between the first region and the second region;
the aerosol changing portion is configured to redirect a stream of the aerosol flowing in a direction away from the aerosol discharge port to a direction toward the aerosol discharge port;
the case body is semicircular in shape and has a first curved wall surface that surrounds a portion of the external air introduction tube, the first wall surface is provided with the aerosol discharge port, and a second wall surface opposite to the first wall surface;
the second wall surface is a flat planar surface;
a distance from the second wall surface to the atomization portion along a horizontal plane passing through the atomization portion being smaller than a distance from the first wall surface to the atomization portion along the same horizontal plane;
the second wall surface is the aerosol stream changing portion;
the first region of the aerosol carrier path extends vertically through the case body;
the aerosol discharge port is directly disposed vertically above a reservoir that surrounds the external air introduction tube; and
the compressed air tube unit being off center from a vertical axis of the case body.

US Pat. No. 10,137,259

PORTABLE ULTRASONIC NEBULIZER AND NEBULIZATION STRUCTURE THEREOF

HCMED INNOVATIONS CO., LT...

1. A nebulization structure, comprising:a carrier unit having a first carrier portion, a first surrounding portion extended outward from an outer perimeter of the first carrier portion, a second carrier portion extended outward from an outer perimeter of the first surrounding portion, and a second surrounding portion extended outward from an outer perimeter of the second carrier portion, wherein the first carrier portion has a through hole, and the first surrounding portion, the second carrier portion and the second surrounding portion are sequentially connected to form a surrounding groove, wherein the first surrounding portion is extended backward and slantwise from the outer perimeter of the first carrier portion;
a vibration unit including an annular vibrating sheet received in the surrounding groove;
a waterproof package unit received in the surrounding groove to enclose the annular vibrating sheet;
a nebulization unit disposed on the first carrier portion, wherein the nebulization unit has a plurality of micro holes communicated with the through hole; and
a position-limiting unit having a first position-limiting portion disposed on the nebulization unit and a second position-limiting portion extended outward and slantwise from an outer perimeter of the first position-limiting portion and along the first surrounding portion, wherein the nebulization unit is positioned between the first carrier portion and the position-limiting unit, and the first position-limiting portion has an opening for exposing the micro holes.

US Pat. No. 10,137,257

SLACK-TIME HEATING SYSTEM FOR BLOOD AND FLUID WARMING

Belmont Instrument, LLC, ...

1. A system for heating an infusate, the system comprising:a reservoir for containing an infusate;
an induction fluid heater comprising a circular single flow path therewithin;
a diversion valve;
a patient line; and
a recirculation line,
wherein the induction fluid heater comprises an inlet to receive the infusate from the reservoir and to direct the infusate to the circular single flow path,
wherein the induction fluid heater comprises an outlet to direct a heated infusate from the circular single flow path into the patient line and/or the recirculation line,
wherein the diversion valve operates to direct the heated infusate from the induction fluid heater into the patient line and/or the recirculation line, said diversion valve controlling a ratio of a flow in the patient line to a flow in the recirculation line,
wherein the patient line directs the heated infusate to a patient, and
wherein the recirculation line directs the heated infusate to the reservoir, so that the system increases a temperature of the infusate in the reservoir.

US Pat. No. 10,137,256

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case adapted to hold a medicament container having a needle;
a needle shroud telescopically coupled to the case and movable between a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered and the needle shroud is inhibited from translating relative to the case; and
a plunger slidably disposed in the case and movable between a proximal position, an intermediate position and a distal position relative to the case,
wherein, when the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the first extended position, and
wherein, when the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.

US Pat. No. 10,137,255

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case having a rib;
a needle shroud telescopically coupled to the case and movable between a first extended position, a retracted position and a locked second extended position;
a carrier slidably arranged in the case and adapted to hold a medicament container, the carrier movable from a first axial position to a second axial position relative to the case;
a collar rotatably and slidably disposed in the case, the collar coupled to the needle shroud and the carrier; and
a control spring biasing the collar in a distal direction relative to the case,
wherein the collar is adapted to abut the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar is adapted to disengage the rib when the needle shroud is in the retracted position and the carrier is in the second axial position,
wherein the collar includes a shroud boss adapted to engage a shroud slot in the needle shroud, a carrier boss adapted to engage a carrier slot in the carrier, and a case boss adapted to engage the rib in the case,
wherein the collar is adapted to couple a force of the control spring to one of the carrier, the needle shroud and the case based on axial and rotational positions of the needle shroud, the carrier, and the rib in the case relative to the collar.

US Pat. No. 10,137,254

TELESCOPIC DRIVE ARRANGEMENT FOR DRUG DELIVERY DEVICE

1. A drug delivery device, comprising:a compartment adapted to receive and hold a drug-filled cartridge having an axially moveable piston,
a support structure,
a drive tube comprising an inner thread,
a motor assembly having a distal portion and a proximal portion, the distal portion comprising a rotatable drive shaft and being adapted to be received inside the drive tube,
a drive member comprising an outer thread, and
a controller for controlling the motor assembly,wherein:the drive member outer thread is in threaded engagement with the drive tube inner thread,
the motor assembly is arranged non-rotational relative to the support structure,
the drive tube is arranged axially displaceable but non-rotational relative to the motor assembly and is adapted to engage and axially move, directly or indirectly, the piston of a loaded cartridge to thereby expel drug from the cartridge,
the motor assembly proximal portion is connected to the support structure via a first flexible joint, and
the drive shaft is connected to the drive member via a second flexible joint,whereby rotation of the drive shaft results in axial, non-rotational displacement of the drive tube relative to the support structure.

US Pat. No. 10,137,252

PEN-SHAPED TORSION SPRING DRIVEN INJECTION DEVICE

1. A pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug comprising:A housing having a window,
A piston rod having an external thread,
A rotatable piston rod guide engaging and driving the piston rod during dose expelling,
A torsion spring for rotating the piston rod guide,
A rotatable scale drum having a thread engaging the external thread of the piston rod and carrying a plurality of indicia viewable through the window of the housing,
A rotatable dose setting member cooperating with the scale drum such that rotation of the dose setting member during dose setting is transformed to a rotation of the scale drum, and whereinthe piston rod is held inrotatable during dose setting whereby the scale drum rotates helically on the external thread of the piston rod.

US Pat. No. 10,137,251

ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An assembly for a drug delivery device, comprising:a compression spring, wherein the compression spring is compressed during a setting of a dose of a drug;
a sleeve member,
a rotation member, wherein the sleeve member is rotationally fixed and axially moveable with respect to the rotation member;
a dose setting member which is configured to be rotated in a dose setting direction in order to set a dose, wherein a rotation of the dose setting member in the dose setting direction causes a rotation of the rotation member in the dose setting direction, wherein the rotation member is coupled to the dose setting member by means of a drive shaft;
an actuator which is configured to be operated in order to dispense the dose of the drug, wherein the compression spring is enabled to relax when the actuator is operated; and
a locking member which is configured to inhibit a rotation of the rotation member in a dose dispensing direction during the setting of the dose, thereby inhibiting a relaxation of the compression spring,
wherein the compression spring abuts the sleeve member and wherein the compression spring and the sleeve member are configured such that the relaxation of the compression spring effects a rotational movement and an axial movement of the sleeve member in a proximal direction away from a dispensing end of the drug delivery device, thereby causing a dispensing of the dose from the drug delivery device, and wherein the assembly further comprises a housing, wherein the compression spring is arranged between a bearing surface of the housing and the sleeve member, and wherein the compression spring exerts a force on the sleeve member which is directed in the proximal direction.

US Pat. No. 10,137,250

SYRINGE AND PREFILLED SYRINGE

TERUMO KABUSHIKI KAISHA, ...

1. A syringe comprising:a cylindrically-shaped gasket comprising a closed distal end, an open proximal end, and an inner cavity portion extending distally from a proximal side;
a barrel comprising a distal opening portion and configured to slidably contain the gasket; and
a plunger comprising a head portion configured to be contained in the inner cavity portion of the gasket,
wherein the head portion comprises:
a shaft portion, and
a helical rib located at an outer surface of the shaft portion, the helical rib comprising a starting end on a distal side and a terminal end on a proximal side,
wherein the gasket comprises, on an inner surface of the inner cavity portion, a helical crest portion forming a helical valley portion configured to threadedly engage with the helical rib of the plunger, and a plunger-retaining annular rib positioned distally from the helical crest portion, wherein the inner cavity portion further comprises an accommodation portion positioned distally from the plunger-retaining annular rib, the accommodation portion configured to contain a part of the head portion of the plunger at which the helical rib is formed, and wherein the plunger-retaining annular rib further comprises a rib absent portion configured to guide, to the accommodation portion, the helical rib reaching the plunger-retaining annular rib as threaded engagement is advanced between the plunger and the gasket,
wherein the plunger comprises, at the terminal end of the helical rib, an entrance-restricting terminal end portion configured to restrict the entrance of the helical rib into the rib absent portion after the part of the plunger at which the helical rib is formed is contained in the accommodation portion of the gasket,
wherein the helical rib includes a proximal surface extending outward from the shaft portion, a distal surface extending outward from the shaft portion, and an outer surface extending between the proximal surface to the distal surface, and
wherein the entrance-restricting terminal end portion comprises a terminal end surface that extends (i) between the proximal surface of the helical rib and the distal surface of the helical rib, and (ii) between the shaft portion and the outer surface of the helical rib.

US Pat. No. 10,137,249

PRIMING CONFIGURATION FOR A MEDICAL DEVICE AND DRUG DELIVERY DEVICE COMPRISING A PRIMING CONFIGURATION

Sanofi, Paris (FR)

1. A priming configuration for a medical device, the priming configuration comprising:a piston rod configured to operate the device; and
a movable element comprising an inclined surface being arranged to engage the piston rod, wherein the inclined surface is arranged to be movable in a transverse direction with respect to the piston rod by a user of the medical device, wherein the inclined surface slides along the piston rod during a movement of the inclined surface in the transverse direction, and wherein the movement of the inclined surface in the transverse direction from one end of the inclined surface to an opposite end of the inclined surface causes the engagement of the inclined surface and the piston rod to advance the piston rod in a further direction different from the transverse direction thereby providing a priming of the medical device before use.

US Pat. No. 10,137,248

AUTO-INJECTION DEVICE

SHL Group AB, Nacka Stra...

1. A medical delivery device comprising:a housing; and
a syringe holder having a syringe holder wall comprising a substantially tubular shape, the syringe holder wall being parallel to a longitudinal axis of the medical delivery device, the syringe holder wall comprising:
an open proximal end,
a slot extending from the open proximal end, resulting in a C-shaped cross sectional shape of the syringe holder wall in the proximal end,
wherein the open proximal end comprises a C-shaped proximal supporting collar arranged around an inner periphery of the syringe holder wall, wherein the C-shaped proximal supporting collar is configured such that, when a syringe having an outer diameter that is greater than an inner diameter of the C-shaped proximal supporting collar is longitudinally inserted into the syringe holder, the C-shaped proximal supporting collar flexes radially outward from a first position to a second position for allowing a tubular needle shield of the syringe to pass until a neck of the syringe is supported by the C-shaped proximal supporting collar, and
an open distal end comprising a distal supporting collar, wherein the distal supporting collar is arranged around and in contact with an outer periphery of the syringe holder wall, and wherein the distal supporting collar comprises a surface that is perpendicular to the longitudinal axis and configured to abut a proximal side of a radially extending flange of the syringe after the syringe is inserted into the syringe holder,
wherein the syringe holder is movably arranged in the housing between a distal position in which the syringe can be longitudinally inserted into the syringe holder and a proximal assembled position,
wherein an outer periphery of the proximal end of the syringe holder is configured to be radially supported by at least one contact surface on an inside surface of the housing when the syringe holder is in the proximal assembled position, and
wherein the at least one contact surface is configured to prevent the C-shaped proximal supporting collar from flexing radially outward to the second position when the syringe holder is in the proximal assembled position, thereby restraining the syringe within the syringe holder.

US Pat. No. 10,137,247

APPARATUS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS TO MUCOUS OR SEROUS MEMBRANE

1. A method, comprising:receiving from a sensor at least one body signal from a patient;
detecting a condition of said patient based on said body signal, said detecting a condition being detected by a therapy device; and
administering a therapy with said therapy device to at least one of a mucous membrane or a serous membrane of said patient, in response to said detecting; wherein said body signal is a signal indicative of a concentration of a therapeutic medication in a body fluid; said condition is said concentration of said therapeutic medication being above a second concentration; and said therapy comprises at least one of reducing a dose of said therapeutic medication, reducing a rate of delivery of said therapeutic medication, or delaying a delivery of said therapeutic medication.

US Pat. No. 10,137,246

INFUSION PUMP ASSEMBLY AND METHOD

Bigfoot Biomedical, Inc.,...

1. A medical infusion pump system, comprising: a portable pump housing configured to receive insulin for dispensation to a user, the pump housing at least partially containing a pump drive system to dispense the insulin through a flow path to the user; a controller communicatively coupled with the pump drive system to cause dispensation of the insulin from the portable pump housing, the controller having computer memory for storing instructions, and one or more processors for executing the instructions stored in the computer memory; a first wireless communication device configured to receive a suggested bolus dosage amount from a mobile device, wherein the suggested bolus dosage amount has been calculated by a dosage calculator executing on the mobile device, the dosage calculator using at least one recent blood glucose measurement of the user to calculate the suggested bolus dosage amount; and a near field communication (NFC) circuit configured to receive NFC communications from the mobile device; wherein, the instructions stored in the computer memory, when executed by the one or more processors of the controller, cause the controller to perform operations comprising: in response to receiving the suggested bolus dosage amount from the mobile device, prompting the user for confirmation of acceptance of the suggested bolus dosage; receiving an NFC communication, via the NFC circuit, indicating confirmation of acceptance of the suggested bolus dosage; and in response to receiving the NFC communication indicating confirmation of acceptance of the suggested bolus dosage, controlling the pump drive system to cause dispensation of the suggested bolus dosage.

US Pat. No. 10,137,245

CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY

University of Florida Res...

1. A system for monitoring and control for safe administration, reduction or cessation of administration of at least one of medication to a subject, comprising:(a) at least one photoplethysmography (PPG) sensor adapted to secure to a central source site of the subject;
(b) an infusion pump for delivering the at least one medication to the subject, wherein the infusion pump comprises an infusion controller for increasing or decreasing flow of medication to the subject; and
(c) an infusion pump agnostic safety device that is adapted to be deployed onto tubing adapted to deliver the at least one medication from the infusion pump to the subject, wherein the safety device comprises an occlusion apparatus and an occlusion controller, wherein the occlusion controller receives signals from the PPG sensor, calculates at least one respiratory parameter based on the signals from the PPG sensor, and if the at least one respiratory parameter is determined by the occlusion controller to be adverse, the occlusion controller directs the occlusion apparatus to partially or completely occlude the tubing
wherein the infusion pump agnostic safety device only occludes the tubing in the event the occlusion controller determines that an adverse event has occurred.

US Pat. No. 10,137,244

MICROFLUIDIC DRUG DELIVERY DEVICES WITH VENTURI EFFECT

ALCYONE LIFESCIENCES, INC...

1. A microfluidic convection-enhanced-delivery (CED) device, comprising:a shank portion;
at least one fluid delivery conduit having a proximal end, a distal end, a fluid inlet port, and at least one fluid outlet port, the at least one fluid delivery conduit being formed in or on the shank portion, the at least one fluid delivery conduit comprising first and second upstream lumens and a single downstream lumen;
a flow restriction formed within the at least one fluid delivery conduit at a merge of the first and second upstream lumens into the single downstream lumen, the flow restriction being configured to adjust a pressure of fluid being directed through the at least one fluid delivery conduit;
wherein the flow restriction comprises a constricted region of the at least one fluid delivery conduit having a cross-sectional area that is less than a cross-sectional area of a proximally-adjacent portion of the at least one fluid delivery conduit;
wherein the at least one fluid outlet port includes a plurality of fluid outlet ports formed in the first and second upstream lumens and a plurality of fluid outlet ports formed in the single downstream lumen; and
wherein the plurality of fluid outlet ports formed in the first and second upstream lumens are formed in an outermost surface of the microfluidic CED device and disposed such that fluid exits from the first and second upstream lumens directly to a location exterior to the microfluidic CED device.

US Pat. No. 10,137,242

FLUID DISPENSING DEVICE WITH A FLOW DETECTOR

Roche Diabetes Care, Inc....

1. A portable therapeutic fluid delivery device for delivering a therapeutic fluid into a body of a patient, the fluid delivery device comprising:a first part comprising,
a driving mechanism,
a flow detector comprising at least one heating element and at least two temperature sensors, and
a processor;
a second part comprising,
a reservoir,
an exit port, and
a delivery tube communicating between the reservoir and the exit port;
wherein the first part and the second part are designed such that upon pairing of the first part with the second part, the at least one heating element and the at least two temperature sensors touch the delivery tube, and wherein the processor, upon activation of the at least one heating element, determines a flow condition of the therapeutic fluid inside the delivery tube based on signals provided by the at least two temperature sensors.

US Pat. No. 10,137,241

AUTOMATED INSERTION ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

1. An automated insertion system comprising:a cartridge assembly comprising:
a toothed track;
a toothless groove; and
at least one dermal perforation assembly having an interior passage configured to releasably engage at least a portion of a subdermal device therein; and
an actuation assembly configured to drive the at least one dermal perforation assembly a predetermined distance, the actuation assembly comprising:
a drive gear set comprising an uppermost gear, the drive gear set for engaging the cartridge assembly;
an actuator; and
a torsion spring,
wherein when the uppermost gear of the drive gear set is engaged with the toothed track of the cartridge assembly, the actuator is raised and the torsion spring is wound,
wherein after the at least one dermal perforation assembly is driven the predetermined distance, the uppermost gear of the drive gear set is seated in the toothless groove.

US Pat. No. 10,137,240

CAPILLARY CHANNEL STRUCTURE FOR DISPENSE INTERFACE

Sanofi-Aventis Deutschlan...

1. A dispense interface for a drug delivery device for delivering at least two drug agents, comprising:at least two flow regulation structures configured to connect to at least two fluid reservoirs; and
a confluence at which the at least two flow regulation structures meet,
wherein each flow regulation structure has a first end and a second end and comprises:
a fluid inlet opening at the first end, the fluid inlet opening of each flow regulation structure configured to connect to a different one of the at least two fluid reservoirs, and
a fluid outlet opening at the second end connected to the confluence,
wherein one or more of the at least two flow regulation structures each further comprises a capillary fluid channel that ends at the confluence,
each capillary fluid channel having a volume configured to contain a backflow from one or more others of the at least two flow regulation structures, and arranged in a meandering pattern on a plane perpendicular to a direction of fluid flow through an outlet of the confluence.

US Pat. No. 10,137,239

SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE

Avedro, Inc., Waltham, M...

1. A system for monitoring treatment of corneal tissue, comprising:an excitation source that directs light to the corneal tissue treated with a cross-linking agent, the light causing the cross-linking agent to fluoresce;
an image capture system that captures one or more images of the corneal tissue in response to the excitation source directing the light to the corneal tissue, the one or more images showing the fluorescing cross-linking agent; and
a controller that is configured to receive the one or more images of the corneal tissue and to provide information relating to cross-linking activity with the cross-linking agent in the corneal tissue based on one or more wavelengths emitted by the fluorescing cross-linking agent,
wherein the excitation source directs the light to the corneal tissue along an axis; the image capture system includes a camera and a lens; the camera captures the one or more images of the corneal tissue via the lens; the camera and the lens are offset from the axis defined by the light; the camera defines an image plane; the lens defines a lens plane; the lens plane is separate from the image plane; the one or more images of the corneal tissue are associated with a focal plane defined by the camera and the lens; and the camera and the lens are oriented such that the image plane, the lens plane, and the focal plane all intersect each other at a common intersection.

US Pat. No. 10,137,237

NEEDLE ARRANGEMENT

1. A needle arrangement for an injection device comprising:a needle cannula having a lumen and mounted such that a distal part having a distal tip extend in a distal direction,
a telescopically movable shield slidable between a first extended position and a second retracted position and wherein the telescopically movable shield distally carries a cleaning chamber containing a cleaning solvent for cleaning at least the tip of the needle cannula between subsequent injections and which cleaning chamber at least distally is provided with a pierceable distal septum, wherein the telescopically movable shield in the first extended position is extended to at least cover the distal tip of the needle cannula and in the second retracted position is retracted to at least expose the tip of the needle cannula,
a telescopically movable tube for guiding the needle cannula, the telescopically movable tube having a tube lumen and a distal end wherein the needle cannula is guided inside the tube lumen, and which tube lumen is movable relatively to the needle cannula, and wherein the distal end of the telescopically movable tube at least partly penetrates the distal septum when the telescopically movable shield is moved from the first extended position to the second retracted position.

US Pat. No. 10,137,231

INTRA-AORTIC BALLOON APPARATUS, ASSIST DEVICES AND METHODS FOR IMPROVING FLOW, COUNTERPULSATION AND HAEMODYNAMICS

1. A circulatory assist apparatus for use to generate pressure and create and augment flow in an aorta or other circulatory lumen, the apparatus comprising:an inflatable pumping balloon having a proximal end joined to an elongated balloon catheter, the balloon catheter having a distal end joined to the pumping balloon and a proximal end, separated from the distal end by a length sufficient to extend from within the circulatory lumen to the outside of a patient's body, for receiving positive and negative pressure pulses from a pump to inflate and deflate the pumping balloon; and
a radially and reversibly expandable frame, mounted on one of a segment extending distally from the pumping balloon, the balloon catheter, and a sleeve tube surrounding the balloon catheter;
wherein the expandable frame is manipulable to expand and collapse within the circulatory lumen, and functions to space apart the inflatable pumping balloon, when inflated, from the circulatory lumen, said expandable frame having a first diameter in a collapsed configuration for intraluminal delivery and withdrawal and a second, larger diameter in an expanded configuration achieved by said manipulation; and
wherein said expandable frame includes a radially and reversibly expandable check valve mounted on said expandable frame and configured to, upon expansion, substantially block flow away from the inflatable pumping balloon and permit flow toward the pumping balloon.

US Pat. No. 10,137,229

TREATING CONGESTIVE HEART FAILURE

Mayo Foundation for Medic...

1. A method for treating heart disease in a mammal using an assist device comprising (i) a conduit comprising a proximal region, a distal region and an intermediate region located between said proximal and distal regions, wherein said proximal region is adapted to be positioned within an aorta of said mammal, wherein said distal region is adapted to be positioned within a left atrium of said mammal, and wherein said intermediate region is adapted to define a lumen through a shared wall between said aorta and said left atrium, and (ii) a pump, wherein said pump is adapted to be positioned within said conduit,wherein said method comprises implanting said assist device with said proximal region positioned within said aorta, said distal region positioned within said left atrium, and said intermediate region positioned to extend from said aorta to said left atrium across said shared wall between said aorta and said left atrium without being positioned outside of said aorta, said left atrium, and said shared wall, wherein said shared wall extends along the ascending aorta to the aortic valve,
wherein blood flow in said mammal is enhanced, thereby treating said heart disease.

US Pat. No. 10,137,228

SYSTEM AND METHOD FOR SEALING AN INCISIONAL WOUND

KCI Licensing, Inc., San...

17. A system to treat an incisional wound having incisional walls, the system comprising:a scaffold fluidly coupled to a conduit to receive reduced pressure from a reduce pressure source, and configured to be positioned within the incisional wound adjacent the incisional walls, the scaffold being formed from an elongated porous material; and
an internal manifold having a primary flow channel extending within the scaffold and configured to be fluidly coupled to the conduit, wherein the primary flow channel is formed by an alignment of interconnected pores of the scaffold.

US Pat. No. 10,137,227

BONE MARROW ASPIRATION DEVICE

SpineSmith Partners, L.P....

6. A method for extracting bone marrow from a subject comprising the steps of:inserting a needle of a bone marrow aspiration device into a bone of a subject, the bone marrow aspiration device comprising:
a housing configured to couple to a first syringe, a second syringe, and a needle;
a first one-way valve disposed within the housing and positioned between the needle and the first syringe, the first one-way valve configured to allow a fluid to only flow from the needle to the first syringe;
a second one-way valve disposed within the housing and positioned between the first syringe and the second syringe, the second one-way valve configured to allow a fluid to flow only from the first syringe to the second syringe; and
a coupler disposed within the housing and joining flow paths of the first syringe, the first one-way valve, and the second one-way valve together;
creating a vacuum in the first syringe sufficient to withdraw bone marrow from the subject through the needle into the first syringe;
filling a portion of the volume of the first syringe with bone marrow;
releasing the bone marrow from the first syringe into the second tubing; and
causing the second syringe to fill with bone marrow from the first syringe.

US Pat. No. 10,137,226

MEDICAL DRAINAGE DEVICES WITH CARBON-BASED STRUCTURES FOR INHIBITING GROWTH OF FIBROBLASTS

Mobius Therapeutics, LLC,...

1. A composition for use in manufacturing an implantable medical device, having a body with an opening therethrough defining a fluid path for passage of body fluids therethrough, the composition comprising:a carbon scaffold consisting essentially fibers combined with a biocompatible polymer; and
a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;
wherein: the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

US Pat. No. 10,137,223

ALIGNED FIBER AND METHOD OF USE THEREOF

LifeNet Health, Virginia...

1. A scaffold comprising one or more electrospun fibers comprising collagen, wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180° apart from each other.

US Pat. No. 10,137,219

COHERENT BLOOD COAGULATION STRUCTURE OF WATER-INSOLUBLE CHITOSAN AND WATER-DISPERSIBLE STARCH COATING

1. An absorbent layer comprising a non-woven fabric layer of water-insoluble chitosan fibers having a continuous coating of water-absorbent starch on at least one face of the fabric layer, wherein the starch has been modified to include hydrophilic groups into or onto molecular chains of the starch.

US Pat. No. 10,137,216

FLUID DISINFECTION DEVICE AND METHOD

Molekule Inc., San Franc...

1. A device for decontaminating a fluid, comprising: a porous filter medium having a predetermined path of fluid travel therethrough, the porous filter medium comprisinga filter, and
a fiber having a first end and a second end, wherein the first end is fixed to the filter and the second end is freely movable within the predetermined path of fluid travel, wherein the fiber is operable between a first configuration and a second configuration, wherein the fiber is opaque;at least one photocatalytic particle disposed on the fiber between the first and second ends for generating electron-hole pairs and having a cross sectional area normal to the path of fluid travel;a source of photons having a wavelength corresponding to at least a band gap energy of the at least one photocatalytic particle, and arranged to illuminate the at least one photocatalytic particle during device operation; andan agitator coupled to the porous filter medium, the agitator operable to oscillate the fiber, relative to the filter wherein the filter is fixed, between the first configuration and the second configuration during device operation, wherein the at least one photocatalytic particle is swept through an area greater than the cross sectional area in a direction normal to the path of fluid travel.

US Pat. No. 10,137,214

STERILIZATION CONTAINER WITH MOVABLE AND NESTABLE LID

SYMMETRY MEDICAL MANUFACT...

1. A sterilization container comprising:a floor;
a first sidewall connected to a first side of the floor and a second sidewall connected to a second side of the floor, wherein the first side is opposite the second side, wherein each of the first and second sidewalls has an elongated blind cavity formed along a length thereof;
a first hinge positioned partially within the blind cavity of the first sidewall, and a second hinge positioned partially within the blind cavity of the second sidewall, wherein each of the first and second hinges are movable along a length of the first and second blind cavities, respectively; and
a lid connected between the first and second hinges, wherein the lid is positionable between at least a first position substantially parallel with the floor on a third side of the floor, and a second position substantially parallel with the floor on a fourth side of the floor, wherein the third side is substantially opposite the fourth side, wherein the lid and the floor each define a plurality of holes adapted to allow a sterilization fluid to pass therethrough;
further comprising a membrane tray insert positioned between the first and second sidewalls, wherein the membrane tray insert is connected to each of the first and second sidewalls.

US Pat. No. 10,137,213

UV DISINFECTING SYSTEM FOR A DENTAL OPERATORY

KAVO DENTAL TECHNOLOGIES,...

1. A fluid treatment system comprising:a dental instrument adapted to receive a fluid;
a fluid supply line configured to be coupled to the dental instrument and to provide fluid to the dental instrument for use of the fluid during a dental procedure, and
a UV source positioned to be in fluid communication with the fluid such that UV light from the UV source disinfects the fluid;
wherein the UV source includes
a conduit adapted to carry the fluid and having a first index of refraction, the conduit having an outside surface;
a pliable sheath surrounding the conduit, the sheath having an inside surface in contact with the outside surface of the conduit, the sheath having a second index of refraction, the second index of refraction being lower than the first index of refraction, and
a light source configured to produce UV light and arranged to send the UV light into the conduit.

US Pat. No. 10,137,212

TETRAHYDROXAMATE CHELATORS OF ZIRCONIUM89 AND NIOBIUM90 FOR USE IN DIAGNOSTIC APPLICATIONS

The United States of Amer...

1. A compound of formula (I) or (II)whereinZ1-Z4 and Z1?-Z4? are the same or different and each is

R1, R2, R3, R4, R2?, R3?, and R4?, are the same or different and each is —(CR6R7)n— or —(CR8R9)m—X—(CR10R11)m?—,
R1? is —(CR6R7)nR12 or —(CR8R9)m—X—(CR10R11)m?—R12,
R5?, R6, R7, R8, R9, R10, R11, and R12 are the same or different and each is selected from hydrogen, alkyl, alkenyl, cycloalkyl, alkoxy, aryl, aryloxy, heteroaryl, hydroxyalkyl, thioalkyl, thioalkoxy, thioaryl, and an amino acid-containing group, wherein each group other than hydrogen is optionally substituted,
X is O, S, or NR13,
R13 is hydrogen, alkyl, alkenyl, cycloalkyl, aryl, or amino-acid containing group, wherein each group other than hydrogen is optionally substituted,
n is an integer selected from 5-7, and
m and m? are the same or different and each is an integer selected from 0-6, such that 4?(m+m?)?6; and
wherein the compound optionally further comprises a biomolecule
(i) that is covalently linked, either directly or through a linker in the compound of formula (I), to a carbon or nitrogen atom of one or more of R1-R4, or
(ii) that is covalently linked, either directly or through a linker in the compound of formula (II), to carbon or nitrogen atom of one or more of R1?-R5? or a nitrogen atom of one or both of Z1? or Z4?.

US Pat. No. 10,137,210

THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION

1. An amyloid binding compound having a structure selected from the group consisting of:wherein at least one of the atoms of the structure is replaced with 3H.

US Pat. No. 10,137,209

GADOLINIUM CHELATE COMPOUNDS FOR USE IN MAGNETIC RESONANCE IMAGING

BAYER PHARMA AKTIENGESELL...

1. A compound of general formula (I), comprising 4, 5, 6, 7 or 8 gadolinium [4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl] groups,
in which:
represents a group selected from:

in which * on the A group indicates a point of attachment of the A group with R1;
R1 represents, independently from each other, a hydrogen atom or a substituent group selected from:

R3,
in which * on the substituent group indicates a point of attachment of the substituent group with A group,
with the proviso that zero or only one of the R1 groups present in the compound represent a hydrogen atom;
n represents an integer of 3 or 4;
R2 represents, independently from each other, a hydrogen atom or a methyl group;
R3 represents a group selected from:

in which * on the R3 group indicates a point of attachment of the R3 group with a nitrogen on the A group or the substituent group;
R4 represents, independently from each other, a hydrogen atom or a methyl group; and
R5 represents, independently from each other, a hydrogen atom or a methyl group;
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

US Pat. No. 10,137,194

IMMUNOGENIC PEPTIDE CONJUGATE AND METHOD FOR INDUCING AN ANTI-INFLUENZA THERAPEUTIC ANTIBODY RESPONSE THEREWITH

The Admininstrators of th...

1. An immunogenic peptide conjugate consisting of a hemagglutinin fusion initiation region (FIR) peptide or a variant thereof, conjugated to an immunogenic carrier protein by a linking group; wherein the hemagglutinin FIR peptide consists of 16 amino acid residues and has an amino acid sequence that consists of SEQ ID NO: 1 or a variant of SEQ ID NO: 1 sharing at least 50% sequence identity therewith and differing from SEQ ID NO: 1 by one or more amino acid substitutions selected from the group consisting of V1I, V1L, V1A, V1G, V1T, V1S, V1M, E2D, E2K, E2R, D3E, T4G, T4S, T4Q, T4A, K5F, K5M, K5I, K5V, K5L, K5A, I6L, I6V, I6A, I6T, I6S, I6Q, I6N, D7E, L8I, L8V, L8A, W9Y, S10T, S10G, S10A, S10M, and E14K; wherein the immunogenic carrier protein is selected from the group consisting of the outer membrane protein complex of Neiserria meningitidis (OMPC), tetanus toxoid protein, diphtheria toxin derivative CRM197, Concholepas concholepas hemocyanin (CCH), hepatitis B virus (HBV) surface antigen protein (HBsAg), HBV core antigen protein, a rotavirus capsid protein, bovine papilloma virus (BPV) L1 protein, a human papilloma virus (HPV) L1 protein, ovalbumin, and a full-length influenza hemagglutinin protein; and wherein the linking group comprises a sulfide bond or a 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group of Formula (I):wherein a primary amine on the carrier protein is bound by an amide bond to the 1-carbonyl moiety of the 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group, and the Cys residue in Formula (I) is bound by peptide bond to the to the N-terminus of the FIR peptide, optionally with an additional spacer peptide of 1 to 5 residues between the Cys and the FIR peptide.

US Pat. No. 10,137,186

COMPOSITIONS AND METHODS FOR LIVE, ATTENUATED ALPHAVIRUS FORMULATIONS

Takeda Vaccines, Inc., C...

1. A live, attenuated alphavirus virus composition comprising:one or more live, attenuated alphaviruses, wherein the live, attenuated alphaviruses are selected from the group consisting of chikungunya (CHIK) virus, o'nyong'nyong virus, Eastern equine encephalitis, Western equine encephalitis, and Venezuelan equine encephalitis;
10.0 mM to 20.0 mM HEPES buffer;
one or more carbohydrate agents having a concentration from 1.0% to 15% (w/v) selected from the group consisting of: trehalose, sucrose, mannitol, sorbitol, and galactose; and
0.1% to 1.0% (w/v) gelatin but does not contain human serum albumin (HSA), wherein the composition stabilizes the live attenuated alphaviruses.

US Pat. No. 10,137,179

COMPOSITION AND METHOD OF PREPARATION OF PROTEASE MICROPARTICULATE SLOW RELEASE PREPARATION

HYALO TECHNOLOGIES, LLC, ...

1. A composition, comprising a plurality of biodegradable polymer microparticies comprising a protease enzyme therein, the biodegradable polymer and the protease enzyme forming a controlled release matrix for extended release of the enzyme; wherein (a) the protease is selected from the group consisting of collagenase, papain, elastase and mixtures thereof; (b) the plurality of the biodegradable polymer microparticies is a mixture of biodegradable polymer microparticles containing different proteases; (c) a first portion of the plurality of the biodegradable polymer microparticles contains collagenase, and (d) a second portion of the plurality of the biodegradable polymer microparticles contains papain or elastase.

US Pat. No. 10,137,161

MEDICAL CANNABIS LOZENGES AND COMPOSITIONS THEREOF

1. A lozenge consisting essentially of extracted cannabis sativa oil, extracted cannabis indica oil, and xylitol, wherein the extracted cannabis sativa oil and the extracted cannabis indica oil comprise cannabidiol and tetrahydrocannabinol.

US Pat. No. 10,137,148

REDUCING THE PROLIFERATION OF ADENOCARCINOMA CELLS (CACO-2) BY ADMINISTRATION OF A POLY-OXYGENATED METAL HYDROXIDE

BAYLOR UNIVERSITY, Waco,...

1. A method of treating a mammal, comprising administering a therapeutically effective amount of a poly-oxygenated aluminum hydroxide composition to the mammal in need thereof to reduce a proliferation of colon adenocarcinoma CaCo-2 cells, wherein the poly-oxygenated aluminum hydroxide composition comprises a clathrate containing fee oxygen gas (O2) molecules; and wherein the therapeutically effective amount of the poly-oxygenated aluminum hydroxide composition ranges from 10 mg/L to 1000 mg/L.

US Pat. No. 10,137,147

REDUCING THE PROLIFERATION OF LUNG CARCINOMA CELLS (A549) BY ADMINISTRATION OF A POLY-OXYGENATED METAL HYDROXIDE

BAYLOR UNIVERSITY, Waco,...

1. A method of treating a mammal, comprising administering a therapeutically effective amount of a poly-oxygenated aluminum hydroxide composition to the mammal in need thereof to reduce a proliferation of lung carcinoma A549 cells, wherein the poly-oxygenated aluminum hydroxide composition comprises a clathrate containing fee oxygen gas (O2) molecules; and wherein the therapeutically effective amount of the poly-oxygenated aluminum hydroxide composition ranges from 10 mg/L to 1000 mg/L.

US Pat. No. 10,137,138

SULFONYLUREA DERIVATIVES OF OLEANOLIC ACID

King Saud University, Ri...

1. A sulfonylurea derivative of oleanolic acid, comprising a compound having the formula:where R is selected from the group consisting H and CH3, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,137,137

ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR AMINOGLYCOSIDES AGAINST PATHOGENIC BACTERIA

Socpra Sciences et Genie ...

1. A method for preventing or treating a bacterial infection in a subject or for the disinfection, sterilization and/or antisepsis of an object contaminated by the bacteria by administering to the subject or applying on the object a compound of formula (I):
wherein:
R1 is H; and R2 is —NR5R6; or
R1 is —NR5R6; and R2 is H;
wherein R5 and R6 are identical or different and are selected from the group consisting of H; substituted or unsubstituted alkyl; substituted or unsubstituted aryl; substituted or unsubstituted aralkyl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted —(CH2)nNR7R8,
wherein n is 2-10; and
R7 and R8 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein the substituted alkyl(s), substituted aryl(s), substituted aralkyl(s), substituted cycloalkyl(s), and substituted —(CH2)nNR7R8 comprise(s) one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl; and
R10 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted —(CH2)pNR13R14,
wherein p is 2-10; and
R13 and R14 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein substituted alkyl, substituted aryl, substituted aralkyl, substituted cycloalkyl, and substituted —(CH2)pNR13R14 comprises one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl,
with the proviso that when R1 is NH2 and R2 is H; or R1 is H and R2 is NH2, R10 is not H,
or a stereoisomer or mixture of stereoisomers or a salt thereof.

US Pat. No. 10,137,134

MOLYBDENUM COMPOUNDS FOR USE IN THE TREATMENT OF CYANIDE POISONING

1. A compound according to the following formula:
Wherein
X is S or a bond; and
R1, R2, and R3 independently or together are one or more of the ligands selected from: a mono- or disaccharide having 3 to 12 carbon atoms, a mono- or di-carboxylic acid having 1 to 5 carbon atoms, which may be substituted with O, S, CH3S— or N, a thiocarboxylic acid having 1 to 5 carbon atoms, a primary, secondary or tertiary amide having 1 to 5 carbon atoms, wherein the side chains attached to the nitrogen is an alkyl having 1 to 5 carbon atoms, threonine, serine, glutamate, malate, oxalate, mercapto succinate, cyanide thiocyanate, thiosulfate, or sulfite; and wherein R3 may be an electron pair.

US Pat. No. 10,137,131

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM

AXSOME THERAPEUTICS, INC....

1. A dosage form comprising a combination of: 1) a complex of meloxicam with a sulfobutyl ether ?-cyclodextrin (SBE?CD), 2) a bicarbonate, and 3) a triptan; wherein the dosage form contains 400 mg to 600 mg of the bicarbonate, about 5 mg to about 50 mg of meloxicam, and about 50 mg to about 200 mg of SBE?CD; and wherein the dosage form is a solid oral dosage form having a shorter Tmax of meloxicam in a human being than a reference dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBE?CD, and 3) does not contain a bicarbonate.

US Pat. No. 10,137,130

METHODS OF TREATMENT OF MALIGNANCIES

Celgene Corporation, Sum...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of FLT3.

US Pat. No. 10,137,125

BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER

NEUPHARMA, INC., Foster ...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, whereinR1, R2, R3, R4, R5, R6, R8, and R10 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl;
R7 is halo;
R9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and
R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

US Pat. No. 10,137,119

ANTI-MALARIAL AGENT

RIKEN, Wako (JP)

1. A method of treating, malaria comprising administering a therapeutically effective amount of one or more compounds selected from the group consisting of(a) a compound of the Formula (III)
whereineach hydrogen (H) is optionally independently substituted with a halogen, C1-C10alkyl, C1-C10 alkoxy, phenyl, hydroxyl (—OH), carboxyl (—COOH), amino (—NH2), benzamide (—NHCOC6H5), benzylamino (—NHCH2C6H5), tert-butylamide (—NHCO-tBu), neopentylamino (—NHCH2-tBu), —C(?O)OR, —S(?O)2OR, or —OP(?O)(OR)(OR?);
R and R? each independently represent hydrogen or C1-C10 alkyl; and further,
each hydrogen (H) in the alkyl, alkoxy, phenyl, “—C6H5” of the benzamide, “—C6H5” of the benzylamino, “-tBu” of the tert-butylamide, and “—CH2—” and “-tBu” of the neopentylamino is optionally independently substituted with a halogen, hydroxyl, amino, —C(?O)OR, —S(?O)2OR, or —OP(?O)(OR)(OR?), and
(b) pharmaceutically acceptable salts and metal complexes thereof, to a subject suffering from malaria.

US Pat. No. 10,137,118

CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

Global Blood Therapeutics...

1. A crystalline ansolvate of Compound 1:
characterized by at least three X-ray powder diffraction peaks (Cu K? radiation) selected from 11.65°, 11.85°, 12.08°, 16.70°, 19.65° and 23.48 °2? (each ±0.2 °2?).

US Pat. No. 10,137,117

CRYSTALLINE N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONO MESYLATE MONOHYDRATE HAVING A SPECIFIC PARTICLE SIZE DISTRIBUTION RANGE AND A SPECIFIC SURFACE AREA RANGE FOR USE IN PHARMACEUTICAL FORMULATIONS

AiCuris Anti-Infective Cu...

1. A composition of crystalline N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]acetamide mono methanesulfonic acid monohydrate particles of the following formula
having a purity of >99%,
wherein said particles in the composition have a particle size range from 2 ?m to 500 ?m, a particle size distribution which is defined by d(0.1) from 2 to 100 ?m, d(0.5) from 30 to 210 ?m and d(0.9) from 70 to 400 ?m and a specific surface area of less than 1.0 m2/g.

US Pat. No. 10,137,116

BENZIMIDAZOLE SULFIDE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF TUBERCULOSIS

1. A method of treating tuberculosis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a benzimidazole sulfide derivative of general formula (I):wherein R is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-heteroalkyl, C1-C6-haloalkyl, aryl, C1-C6-alkyl aryl, heteroaryl, C1-C6-alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6-alkenyl heteroaryl, C3-C8-cycloalkyl, C1-C6-alkyl cycloalkyl, heterocycloalkyl, C1-C6-alkyl heterocycloalkyl, carboxy, C1-C6-alkyl carboxy, acyl, C1-C6-alkyl acyl, acyloxy, C1-C6-alkyl acyloxy, alkoxy, C1-C6-alkoxy, C1-C6-heteroalkoxy, C1-C6-haloalkoxy, C1-C6-alkoxycarbonyl, halogen, sulfanyl, and C1-C6-alkylsulfanyl, a pharmaceutically acceptable salt thereof, and/or a mixture thereof.

US Pat. No. 10,137,110

1-CYCLOHEXYL-2-PHENYLAMINOBENZIMIDAZOLES AS MIDH1 INHIBITORS FOR THE TREATMENT OF TUMORS

Bayer Pharma Aktiengesell...

1. A compound of formula (I)
wherein:
R1 is a halogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, cyano, (C1-C6-alkyl)-S—, and (C1-C6-haloalkyl)-S—;
R2 is a hydrogen atom;
R3 is a hydrogen atom;
R4 is a hydrogen atom;
R5 is a phenyl or heteroaryl group,
wherein said phenyl or heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of:
halo-, cyano, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, nitro, R13O—, R13S—, R13OC(?O)—(C1-C6-alkyl)-, R13OC(?O)—(C2-C6-alkenyl)-, R13OC(?O)—(C1-C6-alkoxy)-, R14(R15)NC(?O)—(C1-C6-alkyl)-, R14(R15)NC(?O)—(C2-C6-alkenyl)-, R14(R15)NC(?O)—(C1-C6-alkoxy)-, (C1-C6-alkyl)-S—, (C1-C6-alkyl)-S(?O)—, (C1-C6-alkyl)-S(?O)2—, (C1-C6-haloalkyl)-S—, —C(?O)OR13, —C(?O)N(R14)R15, —C(?O)N(R14)S(?O)2R16, —N(R14)R15, —N(R14)C(?O)R16, —N(R14)C(?O)R17, —N(R14)S(?O)2R16, —S(?O)2OR13, and —S(?O)2N(R14)R15;
R6 is a hydrogen atom, a halogen atom, or a group selected from the group consisting of C1-C6-alkyl and C1-C6-alkoxy;
R7 is a hydrogen atom;
R8 is C1-C3-alkyl;
R9, R10, and R11
are independently selected from the group consisting of hydrogen and C1-C3-alkyl;
R12 is a hydrogen atom;
R13 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, and (C1-C3-alkoxy)-(C2-C6-alkyl)-;
R14 and R15
are independently selected from the group consisting of:
hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, (C1-C3-alkoxy)-(C2-C6-alkyl)-, H2N—(C2-C6-alkyl)-, (C1-C3-alkyl)N(H)(C2-C6-alkyl)-, (C1-C3-alkyl)2N(C2-C6-alkyl)-, R13OC(?O)—(C1-C6-alkyl)-, 4- to 6-membered heterocycloalkyl, phenyl, heteroaryl, phenyl-(C1-C6-alkyl)-, and
heteroaryl-(C1-C6-alkyl)-,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)NH2;
or
R14 and R15
are taken together with the nitrogen atom to which they are attached to form a 4-6-membered heterocycloalkyl,
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one substituent selected from the group consisting of:
C1-C3-alkyl C1-C3-haloalkyl C1-C3-alkoxy, C1-C3-haloalkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkyloxy, amino, hydroxy, halogen, and cyano,
or
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one or two halogen atoms;
R16 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C3-C6-cycloalkyl)-, C1-C6-haloalkyl, (C1-C3-alkoxy)-(C1-C6-alkyl)-, phenyl, heteroaryl, and 4- to 6-membered heterocycloalkyl,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C1-C3-alkyl, C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkyl, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)N(R14)R15; and
R17 is a group selected from the group consisting of —N(R14)R15 and C1-C6-alkoxy,
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing.

US Pat. No. 10,137,109

CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS

INCURON, INC., Buffalo, ...

1. A method for treating melanoma, comprising intraarterially administering to a patient in need thereof an effective amount of a compound of a structural formula:
wherein Ra is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe; alternatively, either Ra and R1 or NRe and R1 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rb is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe, alternatively, either Rb and R6 or NRe and R6 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic ring or a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rc is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rc and Rd are taken together to form a five, six, or seven-membered aliphatic ring, optionally containing an oxygen atom;
Rd is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rd and R7 together with the atoms to which they are attached form a five or six-membered aliphatic ring;
Re, independently, is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or two Re groups taken together with a nitrogen to which they are attached to form a five or six-membered aliphatic ring;
R1, R2, R3, R4, R5, and R6, independently, are selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, ORe, C(?O)Re, C(?O)ORe, OC(?O)Re, C(?O)N(Re)2, C(?O)NReSO2Re, N(Re)2, NReC(?O)Re, NReC(?O)N(Re)2, CN, NO2, CF3, OCF3, SRe, SORe, SO2N(Re)2, and OSO2CF3;
R7 is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and
n is 1, 2, 3, 4, or 5,
or a pharmaceutically acceptable salt or hydrate thereof and
wherein the intraarterial administration is intraarterial infusion.

US Pat. No. 10,137,105

COMBINATION TREATMENT PROTOCOL

Bionomics Limited, Theba...

1. A method for treating chronic lymphocytic leukemia (CLL) in a patient comprising the step of administering effective amounts of (i) a compound which induces egress of CLL cells from lymph node or bone marrow or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof; and (ii) a compound of Formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof, in either order or simultaneously.

US Pat. No. 10,137,103

COMPOSITIONS AND METHODS FOR THE TREATMENT OF FATTY ACID METABOLISM DISORDERS

1. A method for treating a fatty acid oxidation disorder in a subject, said method comprising administering at least one S-nitrosylating agent to said subject,wherein said S-nitrosylating agent is a mononitrated-diheptanoin.

US Pat. No. 10,137,093

MILRINONE CONTROLLED-RELEASE FORMULATION

Cardiora Pty Ltd., Melbo...

1. An oral controlled-release formulation comprising:(i) a core comprising:
(a) milrinone, or a pharmaceutically acceptable salt thereof;
(b) hydroxypropylmethylcellulose having a viscosity of 80,000 to 120,000 cps:
hydroxypropylmethylcellulose having a viscosity of about 50 cps;
and at least one pharmaceutically acceptable excipient;
and
(ii) a sustained release coating; and
(iii) an enteric coating; wherein the formulation permits the release of milrinone, or a pharmaceutically acceptable salt thereof, into the bloodstream in an amount that is effective to ameliorate symptoms of heart failure for a period of at least 6 hours,
wherein the hydroxypropylmethylcellulose (80,000 to 120,000 cps) and the hydroxypropylmethylcellulose (about 50 cps) are in a ratio of about 1.5:1 to 1:1.5, and the ratio of milrinone, or a pharmaceutically acceptable salt thereof, to total hydroxypropylmethylcellulose is about 1:3 to 1:5, and
wherein the formulation exhibits zero order release of about 100% of milrinone, or a pharmaceutically acceptable salt thereof, over about 12 hours at pH 6.8.

US Pat. No. 10,137,092

DOUBLE-LAYER TABLET AND PREPARATION METHOD THEREOF

1. A method of preparing a double-layer tablet comprising an upper layer on top of a lower layer, comprising:1) pressing a first active ingredient and a first pharmaceutically acceptable excipient to form the upper layer, wherein the upper layer is a sustained-release layer and comprises one or more holes, and the diameter of each hole is between about 2 mm and about 6 mm; and
2) pressing the upper layer onto a second active ingredient and a second pharmaceutically acceptable excipient, which are configured to form the lower layer, to form the double-layer tablet comprising the upper layer on top of the lower layer,
thereby part of the second active ingredient and the second pharmaceutically acceptable excipient of the lower layer are filled into the hole(s) of the upper layer.

US Pat. No. 10,137,089

SOLVENT EXTRACTION FROM BIODEGRADABLE MICROPARTICLES

Rezolute, Inc, Louisvill...

1. A system for reducing a solvent concentration in a plurality of microparticles, the system comprising:an emulsifier that mixes an oil phase from an oil phase mix tank and a water phase from a water phase mix tank;
a first solvent extraction tank in fluid communication with the emulsifier;
a concentration unit in fluid communication with the first solvent extraction tank, the concentration unit comprising a cross-flow filtration column in fluid communication with a second solvent extraction tank;
a washing unit adapted to receive a microparticle concentrate from the concentration unit; and
a water tank separate from the water phase mix tank;
wherein:
the water tank is in fluid communication with the concentration unit without passing through the emulsifier, the first solvent extraction tank, or the washing unit,
the water tank is in fluid communication with the first solvent extraction tank without passing through the emulsifier, the concentration unit, or the washing unit,
the first solvent extraction tank comprises a mixer to keep the microparticles from settling to the bottom of the first solvent extraction tank,
the cross-flow filtration column is operable to remove water and a solvent from the second solvent extraction tank without removing the microparticles, and
the cross-flow filtration column comprises a ceramic membrane.

US Pat. No. 10,137,060

INFANT PACIFIER WITH IMPROVED RETENTION

1. A pacifier, comprising:a nipple portion comprising a bulb and a stem, the bulb extending proximally from the stem;
a shield, the nipple portion extending proximally from the shield, the shield extending radially outwardly about the circumference of the stem and having an outer edge comprising top, side and bottom edge portions, the entire shield outer edge being distal of the bulb;
a retainer portion spaced from the nipple portion, the retainer portion extending proximally and terminating at a contact pad; and
an extension extending between the nipple portion and the retainer portion, at least part of the extension being distal of the nipple portion and attached to the shield, the extension depending below the bottom edge portion of the shield, the extension supporting the retainer portion so as to maintain the retainer portion at a position wherein the retainer portion extends proximally, generally parallel to and spaced from the stem;
wherein the retainer portion is biased toward the nipple portion; and
wherein no portion of the pacifier proximal of the shield extends higher than the top edge portion of the shield when the pacifier is held so that the stem extends horizontally with the top edge portion of the shield higher than the stem.

US Pat. No. 10,137,059

NURSING BOTTLE WITH INTEGRATED COLLAR AND NIPPLE FLANGE VENTING STRUCTURE

3. A single vented container for use for holding a liquid, and for dispensing of the same, said container consisting of a body portion, a neck portion, the neck portion having integral threads, a collar provided for the container, and having internal threads capable of engagement with the neck portion of said container, a nipple provided upon the upper neck portion of the bottle, said nipple having an upstanding dispensing portion, and an integral flange extending radially from the bottom of the nipple, said flange having a vertical aperture extending therethrough, communicating with the interior of the bottle, and said flange having an upper surface, and a flange passage provided upon the upper surface of the flange nipple, communicating with the flange vertical aperture, and extending radially to the perimeter edge of the nipple flange, and communicating with the space between the threads securing the collar to the neck of the bottle, said nipple flange having a lower surface, an integral sleeve provided upon the lower surface of the nipple flange, and said sleeve being in alignment with the vertical aperture through said flange, a vent tube securing with the integral sleeve upon the lower surface of said nipple flange, and said vent tube provided for securing with said integral sleeve for holding the vent tube into position when applied for venting with the single vented container during usage, wherein said container comprises a nursing bottle, and wherein said nipple is a nursing bottle nipple.

US Pat. No. 10,137,056

DEVICE FOR SEXUAL STIMULATION

1. A device for sexual stimulation of a human body, said device comprising a phallus-shaped stimulation body having a thickness and/or a length that is variable in regions, wherein the stimulation body comprises a length adjustment element that is movable to lengthen and shorten the stimulation body in an axial direction in relation to a main body of the stimulation body, and has a hollow cylinder that is mounted on and displaceable on the main body, wherein the stimulation body is provided with permanent magnets to vary the length of the stimulation body, the permanent magnets being arrangeable in a starting position, in which the permanent magnets mutually attract, and in a lengthening position, in which the permanent magnets mutually repel, and the length adjustment element is movable on the main body by movement of the permanent magnets between the starting position and the lengthening position.

US Pat. No. 10,137,055

PORTABLE FITNESS ROLLER

1. A portable fitness roller comprising:an outer contact skin having an outer compressible surface configured for use as a fitness roller, wherein the outer contact skin includes a series of rigid axial stiffeners running parallel to a central roller axis and extending a length of the outer contact skin, adjacent axial stiffeners being joined together via joints parallel to the central roller axis so that the axial stiffeners and outer contact skin can be formed into a tubular expanded shape defining a cylindrical volume and the axial stiffeners may be released from the tubular expanded shape so as to convert to a collapsed shape, the fitness roller in the expanded shape having sufficient strength to support the weight of a person rolling thereon without collapse; and
a plurality of stiffening elements disposed within the outer contact skin so as to contact and radially support the outer contact skin in the tubular expanded shape and that are movable relative to each other to permit the outer contact skin to assume the collapsed shape by manually displacing two of the plurality of stiffening elements located at each longitudinal end of the support structure.

US Pat. No. 10,137,054

MASSAGE DEVICE EQUIPPED WITH INTERCHANGEABLE MASSAGE HEADS

SEB S.A., Ecully (FR)

1. Massage device (1) including:a body (2) which contains a drive mechanism (3),
at least one type of massage head (4, 5, 6, 7 and 8) which includes massage elements,
a transmission mechanism which allows the massage elements to be activated by the drive mechanism,
an installation mechanism (9) which is configured for the installation and removal of the at least one type of massage head with the body, characterized in that the device includes recognition means (146) of the type of massage head installed on the body and control mechanisms (161) for controlling said massage device based on the recognition of the type of massage head, wherein the massage device comprises a reduction gear installed on an output of a motor,
wherein the installation mechanism comprises a snapping mechanism comprising a blockage system with a notch and a release latch,
wherein the recognition means comprises: (i) mechanical sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body; or (ii) magnetic sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body, and
wherein the mechanical or magnetic sensors are formed in grooves of the body that receive protuberances of the at least one type of massage head such that the protuberances trigger the mechanical or magnetic sensors and are recognized based on binary code programmed into a command box.

US Pat. No. 10,137,053

MASSAGE APPARATUS

DAITO ELECTRIC MACHINE IN...

1. A massage apparatus comprising:a backrest for supporting user's back; and
a massager disposed inside the backrest for producing massage action on the user's back,
said backrest having its front side with a two-layer structure, and being provided with a warm-cool air supply section capable of feeding warm air or cool air into an interlayer region of said two-layer structure,
said massager being configured to move up and down along a direction of length of said backrest,
said warm-cool air supply section being located outside of a movement area of the massager,
said movement area of said massager having a shape of an elongated strip that extends in the length direction,
said warm-cool air supply section being disposed on at least a right side or a left side of said movement area,
said two-layer structure comprising a front cover body constituting a front face of said backrest and a back cover body disposed in a state of overlying a back side of the front cover body,
the interlayer region is configured to store warm air or cool air created between said front cover body and said back cover body,
said warm-cool air supply section being connected to the interlayer region and is configured to feed warm air or cool air into said interlayer region,
said warm-cool air supply section including a blower fan, a fan motor, and a heater, the blower fan delivering air to the heater to produce heated air and to feed the heated air into the interlayer region of the two-layer structure, and
when viewed from a lateral direction, the warm-cool air supply section, including the blower fan, the fan motor, and the heater, is located in overlapping relation with the movement area of the massager,
wherein the massage apparatus further comprises a cover plate being plate shaped and overlying a front face of the massager, the cover plate being provided with an opening at a location corresponding to the movement area of the massager,
wherein the warm-cool air supply section includes right and left warm-cool air supply sections being disposed on at least either of a right side and a left side of the opening on a rear face of the cover plate in a horizontal direction, with said opening lying in between the right and left warm-cool air supply sections,
wherein the back cover body is attached to the opening of said cover plate,
wherein the front cover body overlies the cover plate to cover an entire front side of the cover plate,
wherein the right and left warm-cool air supply sections are configured to feed warm air or cool air from a respective open hole of the cover plate, and
wherein the open holes of the right and left warm-cool air supply sections are located at a lower end side of the cover plate.

US Pat. No. 10,137,051

SINGLE TUBE CRUTCH AND METHOD OF NESTING AND PACKAGING THE SAME

Medline Industries, Inc.,...

1. A crutch, comprising:a single tube support comprising an upper leg and a lower leg comprising a slip-resistant tip, the lower leg fully insertable into a first end of the upper leg such that only the slip-resistant tip is exposed;
an underarm support coupled to a second end of the upper leg opposite the first end;
a grip assembly configured to translate along the upper leg between a usage position and a stowed position, the grip assembly comprising an annular receiver and a grip extending distally from the annular receiver;
a plurality of grip assembly apertures disposed along the upper leg, each of which the grip assembly may align when in the usage position; and
a stowage aperture disposed along the upper leg, with which the grip assembly may align when in the stowed position.

US Pat. No. 10,137,048

STRETCHING APPARATUS FOR STRETCHING THE BACK

1. A stretching appliance, comprising:a floor plate (9) having a mast (6, 8) upwardly disposed on said floor plate (9) and having an adjustable height;
a rest mounted on said mast and being configured for supporting a human body, said rest is pivotably mounted to said mast (6, 8) and is being configured to pivot about a horizontal axis (42);
shoulders restraining means adjustably mounted on a first end of said rest and being configured to hold shoulders of a human body laying on said rest;
feet restraining means adjustably mounted on a second end of said rest and being configured to hold feet of the human body laying on said rest; and
an adjusting mechanism configured for adjusting distance between said shoulder restraining means and feet restraining means by way of pivoting the rest about the horizontal axis.

US Pat. No. 10,137,047

AUTOMATED PILOTLESS AIR AMBULANCE

1. An automated pilotless air ambulance system comprising:an air vehicle (AV) having a fuselage, the fuselage having a stretcher mounted thereon for carrying a patient, the air vehicle configured to be dispatched to a point of injury of the patient and further configured to transport the patient to a medical treatment facility;
a plurality of air-lift motors coupled to the fuselage for vertically lifting the air vehicle, each air lift motor being coupled to a mounting arm such that the air lift motors are disposed substantially in the front and back of the fuselage, thereby enabling the stretcher to be transported with the patient thereon into and out of the AV, and wherein each mounting arm is securely coupled to the fuselage to form a low-profile configuration, whereby the patient is nested in the AV such that each air lift motor is disposed substantially on the same plane as the patient;
an automated life support and monitoring patient suite having a plurality of life support and monitoring devices and medical supplies; and
a bidirectional datalink coupled to the air vehicle, the datalink configured to execute the following functions:
receive and send signals to a patient's or first responder's mobile device or a networked device having geolocation capabilities, thereby enabling the air vehicle to obtain a geographic earth location of the patient;
receive and send signals to the patient's or first responder's mobile device for allowing the air vehicle to be autonomously dispatched when contacted by the patient's or the first responder's mobile device or the networked device;
receive and send signals to at least one medical health provider or physician who is using another air vehicle (AV) system to provide guidance to the first responder; and
receive and send signals to the at least one medical health provider or physician in order to allow the at least one medical health provider or physician to monitor the patient's vitals and to prepare the medical treatment facility for the patient's arrival.

US Pat. No. 10,137,046

DISPOSABLE BEDPAN WITH LID

1. A disposable bedpan with lid, comprising:A) a bedpan comprising a base and a sidewall having at least one lateral support, said bedpan further comprises a top ridge and a front ridge, said bedpan further comprises a front top cavity defined between said top ridge and said front ridge;
B) a cover comprising a cover base and a u-shaped cover base ridge, said u-shaped cover base ridge is inserted into said front top cavity when said cover mounts upon said bedpan, said cover is connected to said bedpan by a hinge; and
C) a lid comprising a lid panel, said lid is connected to said bedpan by a lid hinge, said lid further comprises at least one panel locking protrusion that secures upon said cover when in a closed configuration, said cover and said lid seal said bedpan to prevent waste from coming out when in said closed configuration, said lid panel comprising at least one lid ridge.

US Pat. No. 10,137,044

PATIENT SUPPORT APPARATUS WITH SENSOR ASSEMBLY

Hill-Rom Services, Inc., ...

1. A patient support system, comprising:a patient support device including an air fluidizable section, the air fluidizable section including a basin containing fluidization material for creating a two-phase support surface for patient support by distribution of pressurized fluid through the fluidization material, and
a sensor assembly configured to detect a temperature within the air fluidizable section, the sensor assembly comprising:
a housing defining an interior space, the housing being coupled to a wall of the air fluidizable section,
a processor, the processor being positioned within the interior space of the housing,
a thermal conductor, and
a thermal insulator.

US Pat. No. 10,137,040

ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. An absorbent article having a wearer-facing side and a garment-facing side, and extending in a longitudinal direction and a transversal direction, the article comprising:a topsheet on the wearer-facing side for contact with a wearer's skin;
a backsheet on the garment-facing side;
an absorbent core between the topsheet and the backsheet, wherein the absorbent core comprises an absorbent material layer, the absorbent material layer comprising an absorbent material and further comprising a longitudinally-extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;
wherein the absorbent core further comprises a first folding guide dividing the central portion and the first side portion, and a second folding guide dividing the central portion and the second side portion;
wherein the central portion and the side portions form a three-dimensional basin when the absorbent core is folded along the folding guides;
wherein the absorbent article further comprises:
at least one liquid management layer substantially free of superabsorbent polymer, the liquid management layer being at least partially disposed between the topsheet and the absorbent core; and wherein the liquid management layer comprises a liquid management layer's central portion, a first and second liquid management layer's side portions, and a first and second liquid management layer's folding guides between the liquid management layer's central portion and the first and second liquid management layer's side portions respectively, wherein the liquid management layer's folding guides are at least partially superposed with the folding guides of the absorbent core; and wherein each side portion comprises a plurality of winglets arranged in the longitudinal direction, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, wherein neighboring winglets are separated by a gap between their neighboring sides.

US Pat. No. 10,137,039

ABSORBENT CORES HAVING CHANNEL-FORMING AREAS AND C-WRAP SEALS

1. A absorbent core extending in a transversal direction and a longitudinal direction, the absorbent core having a front edge, a back edge and two longitudinally extending side edges, the absorbent core comprising:(a) a core wrap comprising a first substrate and a second substrate wherein each substrate comprises an inner surface and an outer surface;
(b) an absorbent material comprising a periphery defining an absorbent material deposition area, between the first substrate and the second substrate, the absorbent material deposition area encompassing one or more areas substantially free of absorbent material; and
(c) an auxiliary glue applied directly to the inner surface of the first substrate and defining an auxiliary glue application area;
wherein the auxiliary glue at least partially bonds the inner surface of the first substrate to the inner surface of the second substrate through the one or more areas substantially free of absorbent material, so that when the absorbent material swells, the core wrap forms channels in the areas substantially free of absorbent material that have a width from 2 mm to 20 mm;
wherein the auxiliary glue application area is smaller than the absorbent material deposition area and the first substrate and/or the second substrate comprises at least one outwardly extending flap which is folded around at least one of the front, back, or any of the side edges of the core, and the at least one flap is bonded to the external surface of the other substrate to form a C-wrap seal along the at least one edge of the absorbent core; and
wherein the channels do not extend to any edge of the absorbent material deposition area.

US Pat. No. 10,137,038

STERILE ADHESIVE BANDAGE CONTAINING A POCKET

1. An adhesive bandage comprising a base portion having at least one gauze portion adapted to contact a wound in a skin surface and an adhesive portion; the adhesive portion having an adhesive on a first surface of the base portion adapted to adhere to skin around three sides of and peripheral to the wound; the base portion defining a pocket adapted for storing the at least one gauze portion, wherein the pocket comprises a folded over flap of the base portion and a side opening of the pocket allowing inspection and replacement of the at least one gauze portion without having to remove the entire bandage.

US Pat. No. 10,137,036

UNDERWATER MASK

TABATA CO., LTD., Tokyo ...

1. An underwater mask having an up-down direction and a lateral direction, comprising: a mask body having opposing sides and which comprises a lens frame having a lens on a front; a skirt extending rearward from the lens frame; and a strap configured to be coupled to at least one of the opposing sides of the mask body through a buckle, the strap having a plurality of engaging teeth, the buckle comprising: a base; a strap adjuster body; a handling member; and a stopper, the base comprising: a second coupling portion configured to be coupled to a first coupling portion on the at least one of the opposing sides turnably in the lateral direction; a fitting hole; and a spring comprising a locking hook, the strap adjuster body comprising: a plurality of engaging teeth opposite the spring configured to sequentially engage with the locking hook; a fitting shaft configured to be fitted into the fitting hole turnably by a predetermined angle in a circumferential direction of the fitting shaft; a guide shaft configured to be wound by the strap; a slide guide groove extending in the up-down direction; and a pair of guide openings opposite to each other in the up-down direction, the handling member comprising: an approximately V-shaped spring; a slider configured to slide along the slide guide groove; a pair of sliding portions near the slider; and a finger pad outside each sliding portion of the pair of sliding-portions, the finger pads configured to be exposed from the guide openings of the strap adjuster body, the stopper comprising: a pawl configured to sequentially engage with the engaging teeth of the strap; and a sliding contact tapered protrusion near the pawl, the sliding contact tapered protrusion slidably disposed between the pair of sliding portions, wherein the stopper is configured to be held by the strap adjuster body swingably toward a direction opposite to the body.

US Pat. No. 10,137,034

PRESSURE-SENSING VITRECTOMY SURGICAL SYSTEMS AND METHODS

Novartis AG, Basel (CH)

1. A system for providing irrigation into an eye of a patient during a medical procedure, the system comprising:an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including:
a flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient;
an engagement member at the distal end, the engagement member being more rigid than the flexible elongate member and being configured to enter into a vitreous chamber of the eye of the patient; and
at least three pressure sensors internally disposed in the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential associated with a flow impediment along the infusion line between two of the at least three pressure sensors, such that the flow impediment is locatable between the two pressure sensors associated with the flow impediment pressure differential.

US Pat. No. 10,137,033

TORSIONAL MODE NEEDLE FOR PHACOEMULSIFICATION

Moog Inc., Elma, NY (US)...

1. A phacoemulsification needle for attachment to an ultrasonic handpiece operable to drive the needle back-and-forth in opposite longitudinal directions of the needle at a longitudinal drive frequency and a longitudinal drive magnitude, the phacoemulsification needle comprising:a base adapted for removable attachment to the handpiece; and
an elongated shaft extending from the base along a longitudinal axis, the shaft terminating at a distal tip having a cutting edge;
the base and the shaft including an aspiration lumen passing therethrough;
the shaft further including a plurality of external grooves extending in a longitudinal direction of the shaft;
wherein the plurality of grooves have a configuration that converts oscillatory longitudinal drive motion applied at the base of the needle to torsional motion at the tip of the needle, the torsional motion having a fundamental torsional mode frequency and a torsional mode magnitude, wherein the torsional mode magnitude is greater than the longitudinal drive magnitude;
wherein the plurality of grooves are helical grooves extending in the longitudinal direction of the shaft; and
wherein i) the plurality of grooves consists of exactly six grooves each having a helical pitch less than or equal to 22.86 mm, or ii) each of the plurality of grooves has a depth in a range from 0.102 mm through 0.124 mm and an axial length of 7.62 mm or iii) each of the plurality of grooves has a depth in a range from 0.116 mm through 0.142 mm and an axial length of 10.16 mm, or iv) the plurality of grooves consists of exactly five grooves each having a depth in a range from 0.127 mm through 0.152 mm.

US Pat. No. 10,137,032

SLUSH GENERATION

42 TECHNOLOGY LIMITED, C...

1. An apparatus for generating, at a target ice/liquid ratio with a corresponding target temperature, a slush comprising a frozen and non-frozen liquid, the apparatus comprising:a flow path that recirculates the frozen and non-frozen liquid therethrough; and
a heat exchanger, forming part of the flow path, comprising a coolant conduit extending longitudinally through the heat exchanger and a freeze conduit extending longitudinally through the heat exchanger, wherein the coolant conduit and the freeze conduit share a contiguous boundary along their longitudinal length through the heat exchanger such that thermal energy is transferred between the freeze conduit and the coolant conduit to partially freeze the non-frozen liquid in the conduit loop to generate the slush at the target ice/liquid ratio;
wherein the freeze conduit is devoid of an ice scraper and the coolant conduit is configured for flow therethrough of coolant at a temperature below the target temperature, the apparatus being configured to vary the rate of coolant flow through the coolant conduit between a first rate and a second rate that is lower than the first rate.

US Pat. No. 10,137,030

SELF-TITRATABLE MANDIBULAR REPOSITIONING DEVICE

Sleep Science Partners, I...

1. A mandibular re-positioning device, comprising:a first component adapted to receive a user's top teeth and a second component adapted to receive the user's bottom teeth and an intermediate component adapted to fit between the upper component and the lower component and to couple the upper and lower components;
a first mechanism coupling together the upper component with the intermediate component;
the first mechanism coupling the upper and intermediate components in either of two states comprising an unlocked state or a locked state;
the unlocked state allowing the upper and intermediate components to slide, relative to each other, along a sagittal axis, thereby allowing the user's mandible to freely move in an anterior or posterior direction while the mandibular re-positioning device is positioned within the user's mouth;
the locked state bringing the first component into closer contact with the intermediate component, thereby preventing the two components from sliding, relative to each other, along the sagittal axis, thereby preventing any change in mandibular advancement while the mandibular re-positioning device is positioned within the user's mouth;
the first mechanism being able to transition from the unlocked state to the locked state through application of a force along a vertical axis, the force coming from the user biting down;
a second mechanism coupling together the intermediate component with the second component and adapted to allow movement of the user's mandible in a lateral direction while the mandibular re-positioning device is positioned within the user's mouth; and
the second mechanism including a groove along the lateral direction within the second component, the groove coupling to a rail or to a tab on the intermediate component that travels within the groove, the groove being curved within the second component to match a natural movement of the user's mandible.

US Pat. No. 10,137,028

EYEWEAR SYSTEM FOR SECURING LENS ON A USER'S NOSE AND DILATING USER'S NOSE

1. A device for coupling at least one eyewear lens to at least one nasal applique attachable to a user's nose which results in dilation of a nasal passageway, the device comprising:a base engageable with the at least one eyewear lens;
an adjustment shaft coupled to the base and extending longitudinally along a rotation axis, the adjustment shaft being rotatable relative to the base about the rotation axis;
a first pivot unit coupled to the base and pivotable relative to the base about a first pivot axis in response to rotation of the adjustment shaft about the rotation axis; and
a second pivot unit coupled to the base and pivotable relative to the base about a second pivot axis in response to rotation of the adjustment shaft about the rotation axis;
the first pivot unit and the second pivot unit being interactable with at least one nasal applique to magnetically couple the first pivot unit and the second pivot unit to the at least one nasal applique, the magnetic coupling between the first pivot unit and the second pivot unit and the at least one nasal applique imparting a dilating force on the user's nose to dilate the nasal passageway when the at least one nasal applique is attached to the user's nose.

US Pat. No. 10,137,027

NASAL APPLIQUE AND RELATED APPLICATOR FOR APPLYING APPLIQUE TO A NOSE OF A WEARER

1. An applicator for placing a pair of nasal appliques on opposing lateral regions of a nose of a user, the applicator comprising:a base;
a nose rest coupled to the base and adapted to rest adjacent the nose of the user;
a pair of stop members coupled to the base and arranged in generally opposed relation to each other; and
a pair of placement members coupled to the base, each placement member including an arm coupled to the base and a pad coupled to the arm, each placement member being engageable with a respective one of the pair of nasal appliques, each placement member being selectively transitional between a first position and a second position, when each placement member is in its first position, the placement member is positioned adjacent the respective one of the pair of stop members and when each placement member is in its second position, the placement member is moved away from the respective one of the pair of stop members for placing the respective one of the pair of nasal appliques on the nose of the user.

US Pat. No. 10,137,025

DEVICE AND METHOD FOR ELECTRIC STIMULATION OF MUSCLES INVOLVED IN HUMAN PHYSIOLOGICAL GAIT PATTERN AND BRACE TO SUPPORT AN ANATOMICAL JOINT WITH SUCH DEVICE

EVOMOTION GMBH, Luenebur...

5. A device for electrical stimulation of muscles involved in the physiological gait of a human, comprising: an element for electrical muscle stimulation; a sensor to detect information relevant to the muscle stimulation, wherein the sensor comprises a single gyroscope constructed to detect information including an angular speed ? and a swing direction in an extension direction and flexion direction of an anatomical lower leg of the human; an evaluation unit including a microprocessor to evaluate the information detected by the gyroscope and to determine a defined switching time for the muscle stimulation on the basis of the angular speed ? and the swing direction, and to transmit the determined switching time; and a control and regulation unit to trigger muscle stimulation by said element in response to receipt of the determined switching time.

US Pat. No. 10,137,024

APPARATUS, SYSTEM, AND METHOD FOR CONTROLLING MOVEMENT OF AN ORTHOPEDIC JOINT PROSTHESIS IN A MAMMALIAN SUBJECT

Elwha LLC, Bellevue, WA ...

1. A method for preventing dislocation of an orthopedic joint prosthesis in a mammalian subject comprising:providing an orthopedic brace external to the subject's body and including a first member and a second member, wherein the first member is configured to control movement of a first component of an internal orthopedic joint prosthesis and the second member is configured to control movement of a second component of the internal orthopedic joint prosthesis in the subject;
detecting one or more alignment orientations of the first component relative to the second component by one or more sensors in proximity to the first component and the second component of the internal orthopedic joint prosthesis, wherein the one or more sensors contact the internal orthopedic joint prosthesis;
communicating the one or more alignment orientations from the one or more sensors to one or more controllers; and
adjusting an alignment of the first component relative to the second component of the internal orthopedic joint prosthesis in response to a signal from the one or more controllers in operation with the first member and the second member of the orthopedic brace external to the subject's body.

US Pat. No. 10,137,023

COLONNADE (TM) EXPANDABLE INTRAGASTRIC FOOD FLOW LUMEN DEVICE

Medibotics LLC, St. Paul...

1. An implantable expandable intragastric device for reducing food consumption and/or absorption comprising:a plurality of longitudinal expandable members, wherein these expandable members are configured to be inserted into and expanded within a person's stomach, wherein these expandable members are expanded by being filled with one or more flowable substances selected from the group consisting of a gas, a liquid, a gel, and a foam, wherein each expandable member has a proximal surface which is configured to be closer to the gastroesophageal junction, wherein each expandable member has a distal surface which is configured to be closer to the pylorus, and wherein each expandable member has a central axis which spans from its proximal surface to its distal surface, wherein the expandable members have lateral cross sections that are shaped like keystones or rounded trapezoids, and wherein first portions of walls of the expandable members that are closer to a food flow lumen are less elastic than second portions of the walls of the expandable members that are farther from the food flow lumen;
the food flow lumen, wherein this food flow lumen has a proximal opening which is configured to be closer to the gastroesophageal junction, wherein this food flow lumen has a distal opening which is configured to be closer to the pylorus, wherein food flows into the proximal opening and out of the distal opening, wherein this food flow lumen has a central axis which spans from its proximal opening to its distal opening, wherein there is at least one plane of this device which is intersected by the central axis of the food flow lumen and the central axes of the expandable members, wherein the points where the central axes of the expandable members intersect this plane can be geometrically connected to form a polygon, wherein the point where the central axis of the food flow lumen intersects this plane is located inside this polygon, and wherein the expandable members are arranged symmetrically around the food flow lumen in a first cross-sectional plane and in a second cross-sectional plane, but are arranged asymmetrically around the food flow lumen in a third cross-sectional plane which is in between the first and second cross-sectional planes.

US Pat. No. 10,137,022

IMPLANTATION DEVICE WITH HANDLE AND METHOD OF USE THEREOF

QUALIMED INNOVATIVE MEDIZ...

1. An instrument for deploying an implantable medical device in a body lumen, the device comprising:a base member comprising a base handle;
a deployment extension having a distal end and a proximate end, the proximate end is connected to the base handle;
a first tubular member that fits over the deployment extension and is longitudinally slidable over the deployment extension, the first tubular member comprising: a first tubular body with a distal end and a proximate end, and a first handle for controlling movement of the first tubular member; and
a second tubular member that fits over the first tubular member and is longitudinally slidable over the first tubular member, the second tubular member comprising: a second tubular body with a distal end and a proximate end, and a second handle for controlling movement of the second tubular member,
wherein the first handle is located between the base handle and the second handle and wherein the distal ends of the deployment extension, the first tubular body, and the second tubular body are adapted to deploy an implantable medical device, and
wherein the distal ends in each of the deployment extension, the first tubular body and the second tubular body comprises a screw, luer or hub that is configured to facilitate removable attachment of a catheter to the distal ends in each of the deployment extension, the first tubular body and the second tubular body.

US Pat. No. 10,137,021

METHOD AND APPARATUS FOR CONTROLLING THE DEPLOYMENT OF A STENT

VASCUTEK LIMITED, Renfre...

1. A delivery apparatus, the apparatus comprising:a delivery shaft with a tubular prosthesis mounted on a proximal end thereof for insertion into a lumen and a distal end remote from the proximal end, the prosthesis comprising a sleeve and at least one discrete saddle-shaped ring stent with opposing peaks and opposing valleys positioned between the peaks, the at least one discrete saddle-shaped ring stent is attached to the sleeve to maintain the patency of the sleeve after deployment of the prosthesis;
a retractable sleeve adapted to contain the tubular prosthesis mounted on the delivery shaft;
a control handle adjacent the distal end of the delivery shaft;
at least one stent peak control wire extending from the control handle and directly attached to at least one peak of the opposing peaks at an at least one peak connection point;
at least one peak controller at the control handle adapted to control the position of the at least one stent peak control wire to selectively open the at least one peak from a collapsed state and collapse the at least one peak from an open state;
at least one stent valley control wire extending from the control handle and directly attached to at least one valley of the opposing valleys at an at least one valley connection point; and
at least one valley controller at the control handle adapted to control the position of the at least one stent valley control wire to selectively open the at least one valley from a collapsed state and collapse the at least one valley from an open state.

US Pat. No. 10,137,019

MEDICAL INSTRUMENT, RING PROSTHESIS, STENT AND STENTED VALVE

DAIDALOS SOLUTIONS B.V., ...

1. A stent, comprising:a tubular element with an open grid structure which is radially expandable from a compressed condition to an expanded condition, and which has a proximal and distal end; and
a ring structure provided around the tubular element,
wherein the tubular element and ring structure are interconnected,
wherein the ring structure is a variable-diameter ring structure with distal and proximal flange feet,
wherein the ring structure has an axial direction and a radial direction disposed transverse to the axial direction,
wherein the ring structure is constructed from a series of elongated closed loops lying next to one another which, in each case, at the midpoint of the longitudinal sides of the loops, are attached laterally to one another via a junction to form the ring structure, in such a way that a) an imaginary center line through all junctions forms a closed ring and divides each loop into a distal flange foot of said distal flange feet and a proximal flange foot of said proximal flange feet, and b) the ring structure is expandable,
wherein the distal and proximal flange feet each have a fixed end arranged at the imaginary center line and a free end pointing away from the imaginary center line,
wherein the distal and proximal flange feet have a radial position, in which the free ends of the flange feet point in the radial direction,
wherein the distal and proximal flange feet have an extended position, in which the distal and proximal flange feet extend in the axial direction,
wherein the distal flange feet and the proximal flange feet lie in a longitudinal direction of the tubular element when the tubular element is in the compressed condition and the distal and proximal flange feet are in the extended position,
wherein the distal and proximal flange feet, when in the extended position, are under a pre-tension, which, upon release, bends the distal and proximal flange feet from the extended position to the radial position,
wherein, in the extended position, the free ends of the distal flange feet point in the distal direction whilst the free ends of the proximal flange feet point in the proximal direction such that, after the distal and proximal flange feet have bent from the extended position to the radial position, the distal and proximal flange feet interact to clamp surrounding tissue between the distal and proximal flange feet, and
wherein the distal flange feet, at the fixed ends of the distal flange feet, have a concave-curved part including a hollow side facing toward the proximal flange feet, and in the hollow side of the concave-curved part, a filling is provided that is configured to increase a clamping force with which the distal and proximal flange feet clamp the tissue in situ when the distal and proximal flange feet are in the radial position.

US Pat. No. 10,137,018

ENDOVASCULAR ROUTER DEVICE AND METHOD

1. A router device for repairing a tubular vessel of a patient, where the tubular vessel is joined to at least one branch vessel, the router device comprising:a) a single wall and skeleton-free tubular graft having a proximal end and a distal end and at least one unobstructed fenestration formed therein before deployment in the patient, said fenestration adapted to receive and affix a stent, and a malleable annulus formed in a side of said tubular graft wherein the inner diameter of the annulus defines the fenestration and where the annulus inner diameter when deformed has a portion adjacent to the stent with a greater width than the outer diameter of the annulus and said fenestration sized and positioned to generally align with the branch vessel;
b) said distal end of the tubular graft having a diameter less than a diameter of the proximal end, and said single wall of the tubular graft including a tapered portion between the proximal and distal ends, wherein said fenestration is positioned within the tapered portion;
c) a cylindrical element including an outer surface that is adapted to be juxtaposed circumferentially to an interior surface of the tubular vessel so as to releasably affix the proximal end of the tubular graft to an interior surface of the tubular vessel so that the tubular graft may be repositioned within the tubular vessel of the patient; and
d) said distal end of the tubular graft configured so as to be suspended within an aneurysm formed in the tubular vessel when the proximal end of the tubular graft is affixed to the interior surface of the tubular vessel by the cylindrical element.

US Pat. No. 10,137,011

POWERED ANKLE-FOOT PROSTHESIS

Massachusetts Institute o...

1. An autonomous, wearable powered leg device, comprising:a) a controllable powered actuator including a motor being linkable to an ankle joint to thereby impart torque about the ankle joint;
b) a controller that includes an electromyographic processing unit linked to the controllable powered actuator;
c) at least one electromyographic sensor coupled to the electromyographic processing unit and connectable to limb muscles of an individual wearing the device, whereby electromyographic signals measured from the limb muscles are transmitted to the electromyographic processing unit and thereby modulate control commands from the controller; and
d) a plurality of servo controllers, at least one of the servo controllers linking the electromyographic processing unit to the controllable powered actuator, whereby the individual wearing the device can modulate the controller to adjust between the plurality of the servo controllers, wherein the servo controllers include:
i) a torque controller that provides an offset torque during powered plantar flexion push-off of the powered leg device;
ii) an impedance controller that modulates at least one of joint stiffness and damping of the powered leg device during a stance phase of a gait of the individual; and
iii) a position controller that controls foot position of the powered leg device during a swing phase of the gait of the individual.

US Pat. No. 10,137,010

COORDINATING OPERATION OF MULTIPLE LOWER LIMB DEVICES

VANDERBILT UNIVERSITY, N...

1. A method for operating an autonomous powered leg prosthesis for a lower limb of a body having at least one powered joint, at least one sensor for collecting real-time sensor information for the autonomous powered leg prosthesis, and a communications device, the method comprising:generating, via a first control system of the autonomous leg prosthesis, first control data for the communications device to establish a communications link with a second leg prosthesis associated with another lower limb of the body contralateral to the lower limb and having a second control system operating independently of the first control system;
receiving, at the first control system over the communications link, remote data for the second leg prosthesis, the remote data comprising state information for a second finite state model used by the second control system for operating the second leg prosthesis;
generating, via the first control system, second control data for transitioning the autonomous leg prosthesis from a current state in a first finite state model for operating the autonomous powered leg prosthesis to a different state in the first finite state model,
wherein the different state is selected based on the real-time sensor information and the remote data, wherein at least one state in the first finite state model is configured for causing the at least one powered joint to deliver net power, wherein the second control data further comprises instructions to transition the autonomous leg prosthesis to the at least one state only if the state data in the remote data indicates that the second leg prosthesis is in a weight bearing state.

US Pat. No. 10,137,007

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion;
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion; and
at least one spike pivotally attached to at least one of the first and second spaced apart walls of the yoke;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke;
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position; and
wherein the linear motion of the yoke is translated to pivotal motion of the at least one spike from a collapsed position, to a fully deployed position transverse to the mid-longitudinal axis.

US Pat. No. 10,137,006

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween, the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion; and
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke; and
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position.

US Pat. No. 10,137,005

DEVICE AND METHOD FOR DEPLOYMENT OF AN ANCHORING DEVICE FOR INTERVERTEBRAL SPINAL FUSION

Globus Medical, Inc., Au...

1. An intervertebral fusion device comprising:a spacer adapted to be implanted between an upper vertebral body and a lower vertebral body;
a first anchor and a second anchor positioned within the spacer; and
an actuation screw positioned within the spacer and adapted to engage with the first anchor and the second anchor,
wherein when the actuation screw is actuated in a first direction, the first anchor moves to engage the upper vertebral body and the second anchor moves to engage the lower vertebral body, wherein the first anchor and the second anchor are configured to be moved simultaneously, and
wherein each of the first and second anchors includes a first side and a second side opposite the first side, the second side including a plurality of linear cuts configured to engage with the actuation screw.

US Pat. No. 10,137,004

INSERTION TOOLS AND METHODS FOR MINIMALLY INVASIVE SPINAL FUSION CAGE

Vivonics, Inc., Bedford,...

1. An intervertebral support insertion tool system comprising:a tube having a distal open end for insertion in a patient proximate vertebrae and a proximal open end;
a distal intervertebral support;
a shaft received in the tube proximal open end and having an interface for engaging the distal intervertebral support loaded inside the tube; and
a housing supporting the tube and shaft with a first drive mechanism to advance the shaft in the tube and a second drive mechanism to rotate the shaft.

US Pat. No. 10,137,003

LOW PROFILE INTERVERTEBRAL IMPLANT

DePuy Synthes Products, I...

1. A low profile intervertebral implant sized and configured to be implanted between adjacent upper and lower vertebral bodies, the implant comprising:a spacer having a first insertion end, a second end opposite the first insertion end, an upper surface configured to contact the upper vertebral body when the implant is implanted, and a lower surface configured to contact the lower vertebral body when the implant is implanted;
a plate including a first surface and a second surface opposite the first surface, the second surface spaced from the first surface in a first direction, the plate configured to be coupled to the spacer such that the second surface of the plate faces the second end of the spacer, the plate including an upper plate surface configured to face the upper vertebral body when the implant is implanted, the plate including a lower plate surface configured to face the lower vertebral body when the implant is implanted, the plate defining a first through hole configured to receive a first bone screw, the plate further including a first arm that extends from the second surface in the first direction, the first arm including a first inner spacer contacting surface, the plate further including a second arm that extends from the second surface in the first direction, the second arm including a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a second direction that is perpendicular to the first direction; and
a bone fixation element that extends away from the upper plate surface at a location spaced from the first surface in the first direction, the location spaced from the second surface in a direction opposite the first direction;
wherein the second surface, the first inner spacer contacting surface, and the second inner spacer contacting surface combine to define a void that is configured to receive a portion of the spacer, the void defining a first width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a first position, the void defining a second width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a second position, the first width is greater than the second width, and the second width is spaced from the first width in the first direction.

US Pat. No. 10,137,002

STANDALONE INTERBODY IMPLANTS

Globus Medical, Inc., Au...

1. An intervertebral implant for implantation in an intervertebral space between adjacent vertebrae, the implant comprising:a spacer having a superior surface, an inferior surface, a proximal end, and a distal end, wherein the superior surface and the inferior surface each have a contact area configured to engage adjacent vertebrae, the spacer defining an opening extending from the superior surface to the inferior surface of the spacer, and the spacer defining a cutout extending from the proximal end to the opening;
a plurality of inserts, each insert at least partially defining a fastener aperture sized and dimensioned for receiving a fastener; and
a plurality of fasteners, each fastener received in the fastener aperture of each insert for engaging one of the adjacent vertebrae,
wherein each insert is coupled to the spacer such that at least a portion of the insert is received in the cutout in the spacer wherein the superior surface and the inferior surface are configured with a roughened or porous surface, and
wherein the plurality of inserts are spaced from each other,
wherein each of the fastener apertures is positioned in an oblique angle so that the plurality of fasteners extend at an angle from a longitudinal axis of the spacer and configured to engage with one of the adjacent vertebrae,
wherein the spacer includes torsional stabilizers on the superior and inferior surfaces opposite the plurality of inserts.

US Pat. No. 10,137,000

METHOD AND APPARATUS FOR PLACEMENT INTO IATROGENICALLY CREATED SKELETAL VOIDS

1. A method of placing an implant into an iatrogenically created skeletal void within an individual vertebral body, the method comprising:creating a void by removing at least a portion of the individual vertebral body while leaving superior and inferior endplates functionally intact, the void extending through the individual vertebral body from an anterior wall through a posterior wall; and
placing the implant within the void between the superior endplate and the inferior endplate of the individual vertebra such that the implant does not engage with adjacent vertebra thereby permitting the endplates to perform their function.

US Pat. No. 10,136,998

REVISION TOTAL ANKLE IMPLANTS

Wright Medical Technology...

1. A revision implant, comprising:a body extending between a first planar surface and a second planar surface;
a head extending from the first planar surface of the body and configured to couple the revision implant to an additional component of a multi-component prosthesis;
at least one coupling mechanism configured to couple the body to a first bone, wherein the at least one coupling mechanism comprises one or more protrusions extending from the second planar surface of the body; and
a dome-shaped projection extending from the second planar surface and defining a first fastener hole configured to receive a fastener coupling an augment to the body, where the augment is configured to fill a void of the first bone;
wherein the head defines a second fastener hole configured to receive the fastener.

US Pat. No. 10,136,996

IMPLANTABLE PROSTHESIS FOR REPLACING THE HUMAN KNEE JOINT

1. An implantable prosthesis for replacing a human knee joint, comprising:a femoral prosthetic element and a tibial prosthetic element which are articulated with one another by means of a joint device for the purpose of executing a knee bend, the tibial prosthetic element having a through-opening for the passage of a tool, a rod-like tibial shaft anchoring part or an intramedullary lengthening nail,
wherein the joint device is designed to form a guide channel for the passage of the tool, the rod-like tibial shaft anchoring part or the intramedullary lengthening nail from outside, which guide channel is in alignment with the through-opening and is in connection therewith when the tibial prosthetic element and the femoral prosthetic element are arranged at a predetermined angle relative to one another in a functional position corresponding to a knee bend, and
wherein the joint device comprises a joint head which is connected to the femoral prosthetic element and has an interior space in which a joint element connected to the tibial prosthetic element is rotatably guided for guiding the knee bend, a passage opening into the interior space being formed in the joint head and a through-bore being formed in the joint element, the passage and the through-bore being in alignment with one another in the functional position to form the guide channel.

US Pat. No. 10,136,995

METHOD OF FUSING A SACROILIAC JOINT WITH AN IMPLANT WITH STRUTS

JCBD, LLC, Fort Collins,...

1. A method of fusing a sacroiliac joint defined between a sacrum and an ilium, the method comprising:implanting a joint implant at the sacroiliac joint, the joint implant comprising:
a length extending between a proximal end and a distal end;
an exterior surface extending the length;
an interior surface opposite the exterior surface and extending the length, the interior surface defining an internal volume therein;
a wall thickness defined between the external surface and the interior surface;
a proximal opening extending into the internal volume;
a first wall section comprising a first plurality of struts arranged along the length and defining a first plurality of openings extending through the wall thickness; and
a second wall section comprising a second plurality of struts arranged along the length and defining a second plurality of opening extending through the wall thickness,
wherein the first and second plurality of struts are each arranged along lengths of the first and second wall sections, respectively, such that each opening of the first and second plurality of openings are generally polygonal in shape.

US Pat. No. 10,136,994

COMPOSITE INTERBODY DEVICE AND ASSOCIATED MANUFACTURING METHOD

SB Technologies, LLC, Pa...

1. A composite interbody device, comprising:a plastic core having a superior surface and an inferior surface;
a superior endplate and an inferior endplate, each of the superior and inferior endplates including:
(a) a bone interface side for interfacing with bone and having a plurality of pores permitting bone growth therein, and
(b) a core interface side, opposite the bone interface side, having a plurality of voids that accommodate material of the plastic core to couple the endplate to a respective one of the superior and inferior surfaces, the voids being non-porously isolated from the pores to prevent the material of the plastic core from entering the pores.

US Pat. No. 10,136,993

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair system for repairing a native valve of a patient during a non-open heart procedure, the valve repair system comprising:a delivery device having at least one lumen;
a valve repair device configured to be delivered through the lumen of the delivery device, and configured to attach to a native valve of a patient, the valve repair device comprising:
a pair of paddles that are movable between an open position and a closed position;
wherein each paddle includes a main portion and first and second side portions that are integrally formed with the main portion and extend from the main portion and are configured to contour to the shape of the native valve;
wherein the pair of paddles are configured such that the first and second side portions flex away from the main portion upon being attached to the native valve of the patient; and
a pair of gripping members that are configured to attach to the native valve of the patient.

US Pat. No. 10,136,991

REPLACEMENT HEART VALVE IMPLANT

Boston Scientific Scimed ...

1. A replacement heart valve implant, comprising:a braided anchor member configured to actuate between an elongated delivery configuration and an expanded deployed configuration, the braided anchor member formed from a plurality of filaments;
a circumferential seal member disposed about a distal portion of the braided anchor member, the circumferential seal member including a reinforcing band disposed at a distal end thereof; and
a plurality of valve leaflets connected to the braided anchor member;
wherein the reinforcing band is secured to the braided anchor member adjacent a distal end of the braided anchor member by a plurality of lashings, wherein each lashing is attached to two individual filaments of the plurality of filaments.

US Pat. No. 10,136,990

PIGGYBACK INTRAOCULAR LENS THAT IMPROVES OVERALL VISION WHERE THERE IS A LOCAL LOSS OF RETINAL FUNCTION

AMO Groningen B.V., Gron...

1. An ophthalmic lens configured to improve vision for a patient's eye, the lens comprising:an optic with a first surface and a second surface opposite the first surface, the optic having an optical axis that intersects the first and the second surface, wherein the optic when disposed in an eye of a patient is configured to reduce optical errors together with a cornea and an existing lens in the eye of the patient due to at least one of astigmatism or coma for light incident at an oblique angle with respect to an optical axis of the eye of the patient and focused at a peripheral retinal location disposed at a distance from the fovea and at an eccentricity of about 1 degree to about 25 degrees with respect to the fovea in a horizontal or a vertical plane,
wherein the first surface or the second surface of the optic is configured as a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface described by at least one of (i) aspheric coefficients having an order greater than or equal to 8, or (ii) at least six Zernike coefficients,
wherein a thickness of the optic along the optical axis of the optic is less than 1.0 mm,
wherein a refractive power provided by the optic is between ?5.0 Diopter and +5.0 Diopter, and
wherein an astigmatic power provided by the optic is between 0.5 Diopter and 6.0 Diopter.

US Pat. No. 10,136,987

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

LimFlow GmbH, Dresden (D...

1. A device comprising:a longitudinal axis;
a first end portion having a terminal first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being self-expanding;
a second end portion having a second end diameter smaller than the terminal first end diameter, the second end portion being substantially cylindrical, the second end portion having a second length along the longitudinal axis, the second end portion being self-expanding;
an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end portion and the second end portion, the intermediate portion having a third length along the longitudinal axis, the first end portion being frustoconical, the first end portion tapering between the terminal first end diameter and the intermediate portion; and
a graft material coupled to at least the intermediate portion, the device configured to provide fluid flow between a first passage in which the first end portion is anchored and a second passage in which the second end portion is anchored.

US Pat. No. 10,136,984

SYSTEMS AND METHODS FOR MESH AUGMENTATION AND PREVENTION OF INCISIONAL HERNIA

THE TRUSTEES OF THE UNIVE...

1. A method for affixing mesh to a fascial incision to reinforce and augment hernia fascia closures, comprising:aligning a mesh strip over the fascial incision using an applicator, the mesh strip being integrated with one or more uni-directional fasteners, each fastener including at least one anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface, the applicator comprising a first tension arm and a second tension arm adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the first and second tension arms adapted to spread the first and second tension arms;
controlling a first horizontal tension of the mesh strip when the mesh strip is placed on the fascial incision by using the handle to spread the first tension arm a first distance from the second tension arm, the first distance corresponding to the first horizontal tension of the mesh strip, wherein the first horizontal tension corresponds to a predetermined amount of horizontal tension applied to the mesh strip by the applicator without application of external force;
affixing the mesh strip under the vertical tension and the first horizontal tension to the anterior abdominal wall fascia by applying a force to the fasteners to thereby achieve tissue penetration of the at least one anchoring mechanism of the one or more fasteners; and incrementally tensioning the mesh strip placed on the fascial incision to reinforce the fascial incision by using the handle to spread the first tension arm from the second tension arm by a second distance that is greater than the first distance, wherein an incremental horizontal tension corresponds to the second distance, the incremental horizontal tension being greater than the first horizontal tension.

US Pat. No. 10,136,983

MEDICAL DEVICE HAVING REMOVABLE DEPLOYMENT DEVICE AND AFFIXATION ELEMENT

ATRIUM MEDICAL CORPORATIO...

1. A medical device, comprising:a first layer having an opening formed therein;
a second layer positioned with respect to the first layer to form a pocket therebetween;
a support member at least partially located in the pocket and reconfigurable to enable removal of the support member from the pocket via the opening, wherein the support member includes a spiral separation line that enables the support member to unravel as material separates along the separation line when reconfiguring for removal via the opening; and
an affixation element located in the pocket between the support member and the second layer, and secured directly to a pocket-facing surface of the second layer by a component selected from the group consisting of stitching, a weld, an adhesive, and a fastener.

US Pat. No. 10,136,982

POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS

Tepha, Inc., Lexington, ...

1. A knitted mesh, woven mesh, nonwoven mesh or braid comprising a poly-hydroxybutyrate homopolymer multifilament yarn, wherein the multifilament yarn has a tenacity of greater than 0.5 g/denier and is produced by a method comprising melt extrusion, allowing the extrudate dwell time to crystallize and drawing the resulting fiber.

US Pat. No. 10,136,981

TISSUE ANCHOR SYSTEM INCLUDING A SUTURE SECURING AN ANCHOR TO A SUPPORT

1. A tissue anchor system comprising:a support having a base and arms extending from the base, where the arms include a first arm separated from a second arm by a central portion of the support, where the support is a knitted mesh having open pores;
a suture inserted through the support, with a first trailing end portion and a second trailing end portion of the suture maintained inside of a conduit;
an anchor comprising a body, a fin extending from the body in a first direction with an eyelet formed in the fin, a pair of radial barrels extending from opposite sides of the body in a radial direction perpendicular to the first direction, with the suture engaged with the eyelet of the fin, and a gripping tab removably attached to the fin, where the gripping tab is adapted to be removed from the fin prior to insertion of the anchor into tissue; and
an introducer having a cannula defining a bore sized to receive the body of the anchor and a slot formed in a wall of the cannula, with the slot sized to receive the fin of the anchor.

US Pat. No. 10,136,980

IMPLANTS AND PROCEDURES FOR SUPPORTING ANATOMICAL STRUCTURES FOR TREATING CONDITIONS SUCH AS PELVIC ORGAN PROLAPSE

Caldera Medical, Inc., A...

1. A method for supporting an anatomical structure comprising:(a) making an entry point in a body of a patient;
(b) engaging a first anchor with a delivery system and inserting the first anchor through the entry point and into a target tissue of the body;
(c) retracting the delivery system from the first anchor and out from the entry point;
(d) reengaging the delivery system with the first anchor by passing a suture extending from the first anchor and out the entry point through a slot in the delivery system and advancing the delivery system towards the first anchor until the first anchor is received by the delivery system;
(e) adjusting a position of the first anchor in the target tissue with the delivery system and retracting the delivery system from the first anchor and out from the entry point after said adjusting;
(f) positioning a support member between the first anchor and a second anchor secured within said body;
(g) locking said support member in position relative to the first and second anchors by passing a mesh portion of the support member through an aperture of one of the first and second anchors and engaging said mesh portion of said support member with projections extending from an interior of the aperture by releasing a tension of a suture loop that passes through said aperture; and
(h) closing said entry point.

US Pat. No. 10,136,979

METHOD FOR CONTROLLING FLOW OF INTESTINAL CONTENTS IN A PATIENT'S INTESTINES

1. An intestinal dysfunction treatment apparatus comprising:an implantable constriction device configured to gently constrict at least one wall portion of a tissue wall of a patient's intestines to restrict a flow of intestinal contents in an intestinal passageway of the intestine's,
a stimulation device configured to stimulate the at least one wall portion of the tissue wall, and
a control device configured to be operable to control the stimulation device to stimulate the at least one wall portion, as the constriction device constricts the at least one wall portion, to cause contraction of the at least one wall portion to further restrict the flow of intestinal contents, wherein the control device is configured to control the constriction device to adjust the constriction of the at least one wall portion, and the control device is configured to control the constriction and stimulation devices independently of each other,
wherein the control device is configured to calibrate the constriction of the at least one wall portion by stimulating the at least one wall portion while adjusting, the constriction of the at least one wall portion until a desired restriction of the flow of intestinal contents in the intestinal passageway is obtained.

US Pat. No. 10,136,978

DOSING APPARATUS

Imaginus Limited, (NZ)

1. A dosing apparatus for dispensing therapeutic and/or preventative product into an orifice of an animal, comprising:a plurality of interlocking cartridges arranged in a stack, each cartridge containing at least one product, and each cartridge including:
a body with a cavity holding at least one product to be dosed,
a nozzle which is in communication with the cavity and which is configured for channelling the product to an orifice of an animal, the nozzle being disposed on the top of the body whereby product is dispensed upwardly from the dosing apparatus to the orifice of the animal,
at least one piston configured to push product from the cavity, and
a recess which is adapted to receive and provide a cover for the nozzle of an identical or similar cartridge; and
a dispenser for holding the cartridges and for dispensing product from each cartridge, one after the other, the dispenser including:
a magazine adapted to receive the stack of cartridges, and
a plunger arranged to drive the piston (s) of one of the cartridges;
wherein the nozzle comprises a cannula without a needle;
wherein the nozzle comprises a tubular section sized to fit within the teat orifice of a dairy cow for mastitis prevention and treatment; and
wherein the nozzle is disposed at an angle relative to the body of 70°-90°.

US Pat. No. 10,136,977

DENTAL TESTING DEVICE FOR HEAT SENSITIVITY

1. A device for testing a heat sensitivity in teeth comprising:a base; and
a testing tip having a cushion,
wherein the cushion comprises a heating element, wherein said heating element is embedded in said cushion; and
wherein the cushion is conformable to a contour of a tooth to be tested for a heat sensitivity and is conformable to contours of different types of teeth and wherein the cushion has a left side and a right side that are mirror images of each other that allows testing of all upper and lower teeth individually; and
being capable of transferring heat energy from the cushion to the top surface and at least one side surface of a tooth tested for heat sensitivity, wherein the surface of the cushion is adaptable to the surface of the tooth for greater surface area contact between the cushion and the tooth enamel allowing for heat energy transfer to the tooth over a larger area and at a level to prevent damage to the enamel layer, the dentine layer, or pulp tissue in the tooth being tested.

US Pat. No. 10,136,976

TOOTHBRUSH VIBRATOR

M-SYSTEM CO., LTD., Osak...

1. A toothbrush vibrator comprising:a vibration applicator having a case that allows a toothbrush to pass therethrough and holds the toothbrush and applying vibration to the toothbrush, the case being hollow pillar-shaped body; and
a grip detachably connected to the vibration applicator and gripped by a user,
wherein the grip has a case that is a hollow pillar-shaped body and is capable of housing a portion of a handle of the toothbrush that protrudes from the vibration applicator toward the grip,
the vibration applicator includes a first magnet provided at a grip-side end portion of the vibration applicator,
the grip includes a second magnet provided at a vibration applicator-side end portion of the grip, and
the vibration applicator and the grip are detachably connected by force of the first magnet and the second magnet attracting each other.

US Pat. No. 10,136,971

POSITIONING JIG AND IMPROVED METHODS TO DESIGN AND MANUFACTURE DENTAL IMPLANTS

1. A method of preparing an artificial prosthesis having two or more adjacent teeth which comprises:(a) preparing an artificial tooth arrangement (ATA) with two or more adjacent teeth in a mold on a positioning jig comprising a member with (i) three or more parallel bores in the member and (ii) one or more means for attaching the member to a dental articulator;
(b) placing at least three rigid struts in the parallel bores of the positioning jig;
(c) using at least one of the rigid struts to align a drill;
(d) drilling an aligned hole into each of the teeth in the mold;
(e) placing a rod in each of the aligned holes of the teeth to form a series of aligned rods;
(f) using the teeth and the aligned rods to prepare a dental mockup;
(g) copying the dental mockup to prepare a dental bridge; and
(h) affixing the teeth using the aligned holes to the dental bridge so as to prepare the artificial prosthesis.

US Pat. No. 10,136,968

DISPOSABLE SURGICAL INTERVENTION GUIDES, METHODS, AND KITS

ISETHCO LLC, San Diego, ...

1. A removable modular surgical guide assembly, comprising:a deformable casting medium, wherein the deformable casting medium defines an open treatment area when positioned on a dentiture of a subject;
a foundation plate circumscribing the open treatment area; and
a sensor array affixed to the foundation plate, the sensor array comprising a flexible circuit having at least two electromagnetic sensors, wherein the at least two sensors are positionable around the open treatment area at, or about at, a gumline of the dentiture of the subject,
wherein the foundation plate and the deformable casting medium are comprised of different materials, and the foundation plate is positioned in contact with the deformable casting medium.

US Pat. No. 10,136,966

ORTHODONTIC APPLIANCE

Dentbend BVBA, Liederker...

1. An orthodontic appliance comprising:a plurality of brackets, each bracket having a base for connection to a surface of a tooth within a row of teeth; and
a body configured to be coupled to each of said brackets, the body being provided with a plurality of connection elements arranged on the body, each connection element being configured to cooperate with a respective one of the plurality of brackets to form a connection between the body and the respective bracket,
wherein each connection element comprises a slot,
wherein each bracket comprises a locking element and a stem protruding from the base to connect the locking element to the base, the locking element being configured to be inserted into the slot of a respective connection element, the locking element being substantially disc-shaped and elongated in a primary axis of the respective tooth and having a larger diameter than the stem,
wherein the locking elements of the plurality of brackets and the slots of the plurality of connection elements define locking means for removably connecting the body to the plurality of brackets via the plurality of connection elements,
wherein the slot of each connection element is configured to fit around the locking element of the respective bracket, the slot comprising mating surfaces configured to form a mating engagement with the locking element of the respective bracket and at least one guiding surface configured to guide a top surface of the locking element into the slot, said at least one guiding surface running inward starting at a lower edge of the slot, the slot being a latching slot comprising a tip or protruding section at an interface between said at least one guiding surface and said mating surfaces,
wherein each connection element further comprises a first aperture through which the locking element of the respective bracket can be inserted into the slot and a second aperture configured to slide over the stem of the respective bracket,
wherein the stems of the plurality of brackets are configured so that a distance between the body and the row of teeth is sufficient for insertion and removal of the body and for cleaning of the brackets,
wherein the stem of each of the plurality of brackets is arranged on the base outside of a center of the base and a central axis of the stem is shifted with respect to a central axis of the base such that the stem is configured to define a position of the body that is shifted along the primary axis of the respective tooth with respect to a plane extending perpendicular to the primary axis of the respective tooth and through a center of the row of teeth.

US Pat. No. 10,136,963

SYSTEM AND METHOD FOR INTRODUCING PHOTOSENSITIVE DYES VIA AN INSERT INTO A ROOT CANAL IN A TOOTH, METHOD FOR PRODUCING SAID DYE IMPREGNATED INSERT AND METHOD OF USING SAID DYE-IMPREGNATED INSERT

1. A bactericidal insert for introduction into a canal in a tooth during a root canal procedure, said insert comprising a carrier having a plurality of pores or interstices having been impregnated with a liquid photosensitive dye so that said dye enters said pores or interstices and then said carrier with said liquid photosensitive dye forms a dye-impregnated carrier, said dye-impregnated carrier being configured for insertion within the canal of the tooth and also, the dye can be wet or dried and, if dried, configured to be wetted to dissolve said dye to produce a liquefied dye, said liquefied dye being activatable to produce singlet oxygen or free radicals within said canal when irradiated by light from outside of the tooth;wherein said insert is configured so that a wetting agent can be added thereto to wet said dry dye-impregnated carrier and wherein said insert is packaged in a package with said wetting agent.

US Pat. No. 10,136,962

MULTI-PLANAR PRE-CURVED ROTARY ENDODONTIC FILE

Dentsply Sirona, Inc., Y...

1. An improvement endodontic instrument configured for use in a rotary hand piece and having a working length made of a shape memory material and including a plurality of flutes forming a cutting edge, the improvement comprising:the working length including
a straight non-apical portion whose central longitudinal axis is a central rotational axis of the endodontic instrument and
a pre-curved apical portion whose central longitudinal axis does not lie along the central rotational axis of the endodontic instrument,the pre-curved apical portion beginning at about one-third to one-quarter of the working length as measured from a tip end of the endodontic instrument and ending at the tip end, the pre-curved apical portion having at least three curvatures including at least one curvature that spirals about the central rotational axis of the endodontic instrument, the at least one curvature having a radius of curvature “R” which places the tip end at an angle in a range of about 300 to 750 relative to the central rotational axis.

US Pat. No. 10,136,961

DENTIST TOOL

Viax Dental Technologies,...

1. An overlay for guiding a dental cutting tool defining a longitudinal axis in the removal of predetermined tooth structure from a tooth to be treated, the overlay comprising:an inner surface having a shape and dimensions corresponding to and configured for contacting a contact region on and extending at least partially around either of or both an outer surface of the tooth to be treated and an outer surface of a neighboring tooth of the tooth to be treated such that the inner surface remains releasably fixed to the contact region and in the same position relative to the tooth to be treated upon application of pressure to the overlay during guiding of the dental cutting tool in normal use of the overlay;
a first guiding edge extending through a thickness of the overlay including through the inner surface, the first guiding edge having a contour corresponding to any one or any combination of horizontal, vertical, and tilt movements to be followed by the dental cutting tool in a direction transverse to the longitudinal axis of the dental cutting tool; and
a second guiding edge extending through the thickness of the overlay including through the inner surface, the second guiding edge being spaced apart from the first guiding edge and having a contour corresponding to any one or any combination of the horizontal, vertical, and tilt movements to be followed by the dental cutting tool,
wherein the inner surface of the overlay is configured for extending between top and bottom portions of the respective one or both of the outer surface of the tooth to be treated and the outer surface of the neighboring tooth of the tooth to be treated to which the inner surface corresponds and on which the inner surface is configured for contacting a contact region, the inner surface of the overlay being configured for contacting the respective bottom portion or portions at a respective location or respective locations adjacent to a gingiva of the patient.

US Pat. No. 10,136,960

HAND-HELD ELECTROSURGICAL INSTRUMENT

1. A hand-held instrument, comprising:a handle portion;
an electrosurgical electrode supportably interconnected to and extending distally away from a first end of said handle portion in a first direction;
a signal cable, extending proximally from a proximal end of the handle portion to an interconnected coupler end that is provided to interface with an electrosurgical generator, for transmission of electrosurgical signals to the electrosurgical electrode via the signal cable;
at least one electrically-powered light source, interconnected to said handle portion, for emitting light in said first direction to illuminate a volume extending along the electrosurgical electrode from said first end of the handle portion to a distal end of the electrosurgical electrode;
at least one battery, disposed remotely from said handle portion, to provide electrical power to said at least one light source as a DC signal;
an electrical cable, extending proximally from the proximal end of the handle portion to an interconnected battery module for supporting said at least one battery, to provide said electrical power from said at least one battery to said at least one light source via the electrical cable; and
a switch, interconnected to said handle portion and in electrical communication with said at least one battery by said electrical cable, for selective activation of said at least one light source by said electrical power form said at least, one battery.

US Pat. No. 10,136,953

COMPUTER ASSISTED SURGERY APPARATUS AND METHOD OF CUTTING TISSUE

1. A computer assisted surgery apparatus, the apparatus comprising:a surgical instrument having an intervention member to cut tissue of a body part of a patient;
a control unit arranged to automatically control position and orientation of the intervention member of the surgical instrument in relation to the body part of the patient with regard to a predefined osteotomic line on the body part of the patient; and
a tracking device arranged to track a position and orientation of the body part of the patient,
wherein the surgical instrument comprises an optical monitoring system being fixedly mounted in relation to the intervention member of the surgical instrument, the optical monitoring system being arranged to continuously detect positions of marks applied to the body part of the patient, and
wherein the control unit is arranged to adjust position or orientation, or position and orientation of the intervention member of the surgical instrument when a predefined deviation of the positions of the marks is detected.

US Pat. No. 10,136,950

PATIENT-MATCHED SURGICAL COMPONENT AND METHODS OF USE

Biomet Manufacturing, LLC...

1. A method of performing a surgical procedure aided by a surgical navigation system, comprising:generating a representative model of an anatomical feature from an image of a patient's anatomy;
using the model to make a virtual surgical component;
installing the virtual surgical component on the representative model of the anatomical feature by mating the surface of the component with the anatomical feature in the predefined spatial relationship;
tracking movement of the anatomical feature with a tracking system when a physical surgical component corresponding to the virtual surgical component is moved within a measurement field of the tracking system;
tracking movement of a surgical cutting instrument with the tracking system;
displaying the representative model and the surgical cutting instrument on a display of the surgical navigation system; and
guiding the surgical cutting instrument on the display to verify a cutting plane of the surgical cutting instrument relative to the anatomical feature.

US Pat. No. 10,136,946

SURGICAL ANTENNA STRUCTURE

CREO MEDICAL LIMITED, Ch...

1. A surgical instrument comprising:a surgical spatula comprising a flat paddle and a coaxial cable extending away from a first end thereof, wherein the flat paddle contains a planar microwave conveying structure connected to the coaxial cable, the planar microwave conveying structure being formed from a sheet of a first dielectric material having first and second conductive layers on opposite surfaces thereof, and being open along a side of the flat paddle which extends away from the first end to permit a microwave radiation field to be emitted from that side;
an endoscope; and
a microwave generator connected to deliver microwave energy to the spatula via the coaxial cable, which is arranged to run through an instrument channel of the endoscope,
wherein the coaxial cable comprises an inner conductor, an outer conductor coaxial with the inner conductor, and a second dielectric material separating the outer and inner conductors,
wherein the inner and outer conductors extend beyond the second dielectric to overlap opposite surfaces of the flat paddle to electrically contact the first conductive layer and second conductive layer respectively, and
wherein the first conductive layer is spaced from the first end of the flat paddle to electrically isolate the outer conductor from the first conductive layer.

US Pat. No. 10,136,944

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

AUTONOMIX MEDICAL, INC., ...

1. A composition, for use in blocking at least one of one or more nerves and one or more lymphatic ducts, comprising:a neurolytic agent;
a sympathetic nerve selective neurotoxin for ablating a region surrounding a nutrient artery of a bone; and
an inflammatory agent;
wherein the neurolytic agent comprises ethanol;
wherein the inflammatory agent comprises one or more of poly(lactic-co-glycolic acid) (PLGA), polysaccharides, collagen, silica particles, carbon micro or nanoparticles, and microbeads; and
wherein the sympathetic nerve selective neurotoxin comprises at least one of 6-hydroxydopamine, ?-conotoxin, and bungarotoxin.

US Pat. No. 10,136,943

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,942

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,941

SURGICAL INSTRUMENT AND METHOD OF CREATING THE SAME

JSTONE INC., Mundelien, ...

1. A surgical instrument comprising:a handle portion;
a cylindrical hollow tube secured to the handle portion the cylindrical hollow tube having a first end and a second end wherein the second end of the cylindrical hollow tube is secured to the handle portion;
a clevis unit secured within a cylindrical covering wherein the cylindrical covering has a first end and a second end and wherein second end of the cylindrical covering is located adjacent to the first end of the cylindrical hollow tube;
a first blade and a second blade wherein a portion of the first blade and a portion of the second blade are secured within the clevis unit;
a rubber seal partially covered by the first end of the cylindrical hollow tube and partially covered by the second end of the cylindrical covering;
a first end of the first blade and a second end of the first blade;
a first end of the second blade and a second end of the second blade; and
wherein the second end of the first blade and the second end of the second blade do not extend outside of a circumference of the clevis unit at any time, while the first end of the first blade and the first end of the second blade extend outside of the circumference of the clevis unit.

US Pat. No. 10,136,940

APPARATUS FOR PERFORMING AN ELECTROSURGICAL PROCEDURE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a housing;
at least one shaft extending from the housing, the at least one shaft defining a longitudinalaxis;an end effector assembly operatively connected to a distal end of the at least one shaft having first and second jaw members, at least one of the first and second jaw members pivotable relative to the other from an open position wherein the first and second jaw members are disposed in spaced relation relative to one another, to a clamping position wherein the first and second jaw members cooperate to grasp tissue therebetween under a sealing pressure;
a pivot pin providing an axis of pivot for the pivotable jaw member; and
a monolithic jaw insert operably disposed within at least one of the first and second jaw members, the jaw insert defining an opening configured to securely house the pivot pin, the jaw insert including a moveable member configured to engage a cam pin and configured to provide a camming force to the cam pin and a portion of the sealing pressure to the jaw members when the first and second jaw members are in the clamping position.

US Pat. No. 10,136,938

ELECTROSURGICAL INSTRUMENT WITH SENSOR

Ethicon LLC, Guaynabo, P...

1. An apparatus for operating on tissue, the apparatus comprising:(a) a body;
(b) a shaft extending distally from the body;
(c) an end effector configured to receive energy from an energy source, wherein the end effector comprises:
(i) a first jaw, and
(ii) a second jaw, wherein the second jaw is pivotable relative to the first jaw to transition the end effector from an open configuration to a closed configuration, wherein the first jaw and second jaw define a closure gap between each other when the end effector is in the closed configuration;
(d) a first movable member operatively coupled with the second jaw, wherein the first movable member is configured to move in response to pivoting of the second jaw relative to the first jaw; and
(e) a sensor, wherein the sensor includes a second movable member configured to be engaged by the first movable member, wherein the second movable member is moveable from a first position to a second position in response to movement of the first moveable member when the end effector transitions from the open configuration to the closed configuration,
wherein the sensor is operable to detect that the end effector is in the closed configuration when the second movable member moves to the second position, wherein the sensor is in communication with the energy source, wherein the sensor is operable to communicate a signal to the energy source when the sensor detects the end effector in the closed configuration.

US Pat. No. 10,136,935

DEVICE FOR THE CONTROLLED REMOVAL OF OSSEOINTEGRATED IMPLANTS AND IMPROVED OSSEODISINTEGRATABLE IMPLANTS

1. A medical device for releasing an implant from a bone of a patient to which the implant adheres to, the medical device comprising:a heating/cooling device configured to produce or release heating energy and/or a cooling agent to heat and/or cool the implant;
a controlling device configured to control the heating/cooling device, wherein the controlling device comprises a database storing information and controls the heating/cooling device based on the information stored in the database;
wherein the database comprises:
implant information; and
information defining a temperature, a temperature curve, a heating time, a cooling time, and a frequency of heating and/or cooling suitable to effect osseodisintegration of the implant based on the implant information;
a coupling device configured to releasably connect to the implant while the implant adheres to the bone of the patient, wherein the coupling device is configured to transfer the heating energy and/or the cooling agent produced or released by the heating/cooling device to the implant; and
an input device operably linked with the controlling device, wherein the input device is configured to receive a parameter from an operator operating the medical device, wherein the parameter:
(i) defines a type, dimension, mass, surface structure and/or material of said implant; and/or
(ii) defines an expected amount of osseointegrated surface on the implant; and/or
(iii) defines an amount and/or duration of the heating and/or cooling; and/or
(iv) defines an expected position or region of the osseointegrated surface on the implant; and/or
(v) is selected from the group consisting of
(a) information defining a type, dimensions, mass, surface structure and/or material of the implant or a cavity geometry within the implant;
(b) information defining a form of the coupling device or information defining a thermal conductivity of the coupling device;
(c) information defining a surface of the implant which is osseointegrated;
(d) information defining a type of heating energy and/or cooling agent to be used or information defining an amount of heating energy and/or cooling agent necessary to reach osseodisintegration of an implant as defined in (a); and
(e) information for controlling the heating/cooling device to heat or cool the implant to achieve osseodisintegration of bone material contacting the implant or located within a distance of less than a predefined distance from the surface of said implant;
and/or
(vi) defines bone density of the bone contacting or surrounding the implant; and/or
(vii) defines a date on which the implant was implanted into the patient; and/or
(viii) defines an age of the patient.

US Pat. No. 10,136,932

SPINAL PLATE AND DISTRACTION/COMPRESSION PIN SYSTEM

Camber Spine Technologies...

1. A cervical fixation plate and distraction pin system comprisingtwo or more distraction pins, and
a cervical fixation plate comprising
two or more boreholes for insertion of screws to position and secure the plate on the vertebral surfaces, and
two or more slots for placement of the two or more distraction pins,
wherein one of the slots is located at the inferior end of the plate and another of the slots is located at the superior end of the plate,
wherein each of the slots comprises two parallel straight side walls, and each of the slots is elongated along a longitudinal axis extending along a centerline of the plate, and wherein at least a portion of each of the side walls is ridged and contains a plurality of teeth, wherein the teeth are configured to mate with and secure the plate to a respective one of the pins and are configured to create and maintain compression across a disc space prior to and during securing of the plate on the vertebral surfaces,
wherein two of the boreholes are aligned along an axis substantially parallel to the longitudinal axis, the two boreholes disposed laterally with respect to each of the slots, and
wherein each pin comprises a threaded bone entry end and a ridged portion configured to retain the pin in the respective one of the two or more slots to secure the plate to the vertebral surfaces before attaching the screws, and wherein each pin is configured for removal from the respective one of the two or more slots.

US Pat. No. 10,136,931

BONE FIXATION DEVICE AND METHOD

1. An apparatus for fixation of a fractured bone, comprising:an elongated fixation plate having a longitudinal axis adapted to extend along a long axis of the fractured bone and including a first portion extending along the longitudinal axis of the fixation plate adapted for attachment to a first fragment of the fractured bone and a second portion extending in an opposite direction from the first portion along the longitudinal axis of the plate adapted for attachment to a second fragment of the fractured bone such that the fixation plate is adapted to extend across a fracture between the first fragment and the second fragment of the fractured bone;
a rotational member having a body and a first tab and a second tab extending outwardly and bending in a direction away from a plane of the body; and
a fastener for attaching the body of the rotation member to the elongated fixation plate;
wherein the tabs extending outwardly from the body are adapted for engaging the fractured bone to apply force to the first and second fragments transversely across opposite sides of the fractured bone to produce a torque across the fracture.

US Pat. No. 10,136,930

FLEXIBLE FASTENING DEVICE FOR INDUSTRIAL USE

1. A flexible fastening device to secure two components having curved or misaligned entry paths adjacent one another, said flexible fastening device being a rigid material and having:a body, said body having a length and a diameter, said length to diameter aspect ratio being at least 2, and multiple segments,
one of said multiple segments being a leading segment,
at least one of said multiple segments being a hollow segment;
at least two sinuous slots along at least a portion of said hollow segment to form at least one flexible segment, a first of said at least two sinuous slots extending along a first portion of said hollow segment and a second of said at least two sinuous slots extending along a second portion of said hollow segment,
one of said multiple segments being a trailing segment having a receiving area to receive a rotational force device.

US Pat. No. 10,136,929

FLEXIBLE BONE IMPLANT

IntraFuse, LLC, Logan, U...

1. A bone implant comprising an elongate body having a distal portion and a proximal portion spaced longitudinally relative to a longitudinal axis, wherein:the proximal portion comprises:
a non-threaded outer surface; and
a fully-bounded transverse bore passing through the proximal portion from a first fully-bounded opening in the non-threaded outer surface to a second fully-bounded opening in the non-threaded outer surface; and
the distal portion comprises a helical distal thread formed thereon, the helical distal thread having a major diameter, a minor diameter, and a pitch, the helical distal thread being operable to bend as it is threaded into a bone to follow a curved path, the helical distal thread having a bending stiffness lesser than a bending stiffness of the proximal portion,
wherein a ratio of a bending stiffness of the proximal portion to the bending stiffness of the distal portion is in the range of 2:1 to 20:1.

US Pat. No. 10,136,928

ROD LINK REDUCER

Globus Medical, Inc., Au...

1. A rod link reducer assembly comprising:a manipulator rod having a first end, a second end, and an elongate body extending along a body axis between the first end and the second end;
a post extending outwardly from the rod; and
a rod manipulating joint comprising:
an elongate joint rod extending along a joint rod axis;
a first coupling clamp disposed along the joint rod, the first coupling clamp releasably connectable to the post;
a second coupling clamp disposed along the joint rod adjacent to and rotatable about the joint rod relative to the first coupling clamp, the second coupling clamp releasably connectable to a second post; and
a first biasing member adapted to bias the second clamp against the first clamp,
at least two screw assemblies, a construct adapted to extend between the at least two screw assemblies,
wherein the second end of the manipulator rod comprises a tip, the tip comprising a receiver adapted to releasably secure the construct therein and a receiver axis extending orthogonally to the body axis,
wherein the receiver further comprises a securing member to releasably secure the construct to the receiver, the securing member extending at an angle oblique to the receiver axis, and
wherein the securing member comprises a set screw engaged with a threaded passage and a retainer pin located in the passage to prevent removal of the set screw from the passage.

US Pat. No. 10,136,926

EXPANDABLE SPINAL FIXATION SYSTEM

Globus Medical, Inc., Au...

1. An expandable spinal fixation system comprising:an expandable barrel assembly having:
an upper barrel half having a distal end and a proximal end, wherein the proximal end of the upper barrel comprises a slot formed therein;
a lower barrel half having a distal end and a proximal end, wherein the proximal end of the lower barrel comprises a projection portion configured to be received in the slot; and
a securing assembly having a plate adapted to bias the projection against the upper barrel proximal end and a securing member adapted to releasably bias the plate against the projection, and wherein, when the securing member biases the plate against the projection, the lower barrel half is fixed relative to the upper barrel half; and
a fixed barrel assembly having a body sized to fit between the upper barrel half and the lower barrel half, wherein the body extends along a longitudinal axis,
wherein the upper barrel half is capable of moving with respect to the lower barrel half.

US Pat. No. 10,136,925

SPINAL CROSS-CONNECTOR

NuVasive, Inc., San Dieg...

1. A spinal cross-connector for connecting first and second spinal rods, comprising:an L-shaped elongate member having a long portion with a first end and a short portion with a second end;
a first connector configured to directly attach with a first pedicle screw, said first connector includes a first collet head configured to receive a first tulip head of the first pedicle screw and accommodate a first spinal rod residing within the first tulip head, a first clamp configured to slidably receive the first end of the L-shaped elongate member, a first locking member tightenable over the first collet head that both locks the first end of the L-shaped elongate member with respect to the first clamp, and locks the first connector to the first tulip head; and
a second connector configured to directly attach with a second pedicle screw, said second connector includes a second collet head configured to receive a second tulip head of the second pedicle screw and a plurality of cutouts to accommodate a second spinal rod residing within the second tulip head, a second clamp configured to rotatably receive the second end of the L-shaped elongate member, a second locking member tightenable over the second collet head that both locks the second end of the L-shaped elongate member with respect to the second clamp, and locks the second connector to the second tulip head.

US Pat. No. 10,136,924

POLYAXIAL BONE SCREW

DePuy Synthes Products, I...

1. A polyaxial bone anchor assembly, comprising:a shank having a spherical head formed on a proximal end thereof;
a receiver member adapted to receive a spinal rod and having a distal opening though which the shank extends and a distal seat in which the head of the shank is polyaxially seated; and
a compression cap that is spring biased in a distal direction relative to the receiver member such that the compression cap exerts distal pressure on the spherical head of the shank to frictionally engage the spherical head of the shank.

US Pat. No. 10,136,923

POLYAXIAL BONE FIXATION ELEMENT

DePuy Synthes Products, I...

1. An assembly configured to couple a spinal rod to a vertebra, the assembly comprising:a body that is elongate along a first longitudinal axis, the body including an upper end that defines an upper opening, a lower end that defines a lower opening, a bore that extends between the upper opening and the lower opening along the longitudinal axis, the bore defining a rod-receiving channel configured to receive the spinal rod, the rod-receiving channel disposed along a channel axis that is oriented substantially perpendicular to the longitudinal axis, the bore at least partially defined by a first curved surface that forms a first spherical undercut having a first body diameter, and the bore at least partially defined by a second curved surface that forms a second spherical undercut having a second body diameter that is larger than the first body diameter, the first curved surface positioned closer to the lower opening with respect to a direction parallel to the longitudinal axis than the second curved surface is to the lower opening with respect to the direction, the body further including a collet retention feature positioned at a fixed location between the upper opening and the second curved surface such that the collet retention feature is configured to inhibit movement of a collet that is between the collet retention feature and the lower opening from passing through the upper opening, the collet retention feature defining a retention opening having a third body diameter, and the lower opening defining a fourth body diameter; and
a bone anchor that is elongate along a second longitudinal axis, the bone anchor including a head portion, a shaft portion, and a neck portion positioned between the head portion and the shaft portion, the head portion defining a first screw diameter measured perpendicular to the second longitudinal axis, the shaft portion defining a second screw diameter measured perpendicular to the second longitudinal axis, and the neck portion defining a third screw diameter perpendicular to the second longitudinal axis,
wherein the third screw diameter is less than both the first screw diameter and the second screw diameter, the first screw diameter is less than both the first body diameter and the second body diameter, and the third body diameter is greater than the fourth body diameter and less than the second body diameter.

US Pat. No. 10,136,922

BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE

1. A bone anchoring device comprising:a bone anchoring element;
a receiving part for coupling a rod to the bone anchoring element, the receiving part comprising:
a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving the rod, the recess extending from the first end in a direction of the second end and defining two free legs; and
a second portion at the second end of the rod receiving portion that is connectable to the bone anchoring element, wherein when the bone anchoring element is connected to the second portion of the receiving part, the bone anchoring element and the receiving part are pivotable relative to one another; and
a locking ring configured to be arranged around the second portion of the receiving part, the locking ring comprising a first end, a second end, and an outer surface extending between the first and second ends;
wherein when the bone anchoring element is connected to the second portion of the receiving part and the locking ring is around the second portion, the locking ring can assume a locking position where a compressive force is exerted on the bone anchoring element to lock an angular position of the bone anchoring element relative to the receiving part; and
wherein an engagement structure comprising a projection or a groove is provided on the outer surface of the locking ring, and wherein a portion of the engagement structure forms an abutting surface positioned away from end faces at the first and second ends of the locking ring that is configured to be pushed by a tool to move the locking ring away from the first end of the rod receiving portion towards the locking position, the abutting surface having at least a section that extends axially when viewed in a circumferential direction around the locking ring.

US Pat. No. 10,136,920

ADJUSTABLE CALCANEAL RESTRAINT SYSTEM

1. A treatment method for treating injuries to a patient's calcaneus performing a first surgical procedure wherein a calcaneal pin aperture is created laterally through a patient's calcaneus;inserting a calcaneal pin transversely through the patient's calcaneus;
providing an adjustable calcaneal restraint apparatus, the adjustable calcaneal restraint apparatus comprising:
a rigid framework with a first end configured to be affixed to a lower leg of the patient, and a second end configured for support transverse to the patient's heel;
an adjustment member operably connected to a first end and a second end of the calcaneal pin by a cable, the adjustment member being movably mounted to the second end of the rigid framework such that it can be set in transverse positions across the second end of the rigid framework; and
wherein movement of the adjustment member relative to the second end of the rigid framework changes the calcaneus pin angle;
securing the adjustable calcaneal restraint apparatus to the patient;
adjusting the adjustable calcaneal restraint apparatus to manipulate the patient's calcaneus or pieces of the patient's calcaneus;
imparting a biasing force on the cable between the adjustment member and the calcaneal pin;
waiting an amount of time for the patient's calcaneal and surrounding tissue to be in a desirable condition to perform a second surgical procedure; and
performing the second surgical procedure on the patient's calcaneus to fix the calcaneus or pieces of the calcaneus in a desired location while the adjustable calcaneal restraint apparatus is fixed to the patient.

US Pat. No. 10,136,916

ACCESS DEVICE

Access Scientific, LLC, ...

1. An access device for placing a medical article within a body space, comprising:a needle having an elongated needle body with a distal end and a needle hub from which the needle body extends;
a dilator slideably disposed on the needle body and comprising a dilator hub and an elongated dilator shaft that extends from the dilator hub to a distal end, the dilator hub comprising a receiving portion; and
an insert disposed within the dilator hub and supported by the receiving portion, the insert comprising a through-hole configured to receive the needle body therethrough such that the needle body is capable of extending through the insert, at least a portion of the through-hole being sized and shaped relative to the needle body so as to form a space between the insert and the needle body that allows gases to pass through the space and to the atmosphere but hinders the passage of a body fluid through the space.

US Pat. No. 10,136,915

ULTRASOUND NEEDLE GUIDE APPARATUS

LOVING HEART MEDICAL TECH...

1. An ultrasound needle guide apparatus to aid guidance of a puncturing needle to locate blood vessel positions of a living body and perform puncturing operation, comprising:an ultrasound detection device including a probe head which is configured to contact with the living body to detect the blood vessel positions via ultrasonic waves, a grip shell connected to the probe head, a first hinge portion located on the grip shell, and an image process unit located in the grip shell and electrically connected to the probe head;
a display element which is rotatably connected to the grip shell and includes a second hinge portion hinged on the first hinge portion and a display screen electrically connected to the image process unit through the first hinge portion and the second hinge portion to get ultrasonic signals from the probe head and display the blood vessel positions of the living body; and
a needle positioning aid element fastened to the ultrasound detection device and located beside the probe head, including a body fixed on the ultrasound detection device and a positioning aid support portion located at one side of the body remote from the ultrasound detection device to aid positioning of the puncturing needle;
wherein the body includes a curved section and two clamp sections at two ends of the curved section, the two clamp sections is corresponding with the curved section to clamp the grip shell from two sides of the grip shell, the grip shell includes two guide trough respectively corresponding to the two clamp sections that has an axis perpendicular to the probe head.

US Pat. No. 10,136,913

MULTIPLE CONFIGURATION SURGICAL CUTTING DEVICE

The Spectranetics Corpora...

1. A device for removing an implanted object from a body vessel, the device comprising:an intermediate sheath assembly comprising an intermediate sheath and an intermediate tip disposed at a distal end of the intermediate sheath assembly;
an inner sheath assembly rotatably carried within the intermediate sheath assembly, the inner sheath assembly comprising an inner sheath and a cutting tip, the cutting tip comprising a cutting surface adapted to cut tissue coupled to the implanted object as the cutting tip rotates relative to the intermediate sheath assembly;
a handle assembly comprising a housing, a trigger carried by the housing, and a cutting tip drive mechanism carried by the housing and coupled to the trigger and the inner sheath assembly, the trigger being actuatable to drive the cutting tip drive mechanism and thereby rotate the inner sheath and the cutting tip relative to the intermediate sheath assembly;
an outer sheath assembly rotatably carried outside of the intermediate sheath assembly, the outer sheath assembly comprising an outer sheath and an outer shield disposed at a distal end of the outer sheath assembly, the outer shield comprising a distal opening, the outer sheath assembly being rotatable and translatable relative to the intermediate sheath assembly from a first position to a second position and vice versa, in the first position the cutting surface of the cutting tip being disposed within the outer shield, and in the second position the cutting tip extending through the distal opening and the cutting surface being at least partially disposed outside of the outer shield; and
a shield drive mechanism coupled to the outer sheath assembly, the shield drive mechanism being actuatable to rotate and translate the outer sheath assembly relative to the intermediate sheath assembly from the first position to the second position and vice versa.

US Pat. No. 10,136,911

ANTI-CLOGGING DEVICE FOR A VACUUM-ASSISTED, TISSUE REMOVAL SYSTEM

DePuy Synthes Products, I...

1. A surgical, nucleus pulposus removal system having an anti-clogging device for a vacuum-assisted tissue removal, the system comprising:an anti-clogging device including a tubular cutting head, a suction assembly, a collection handle, the collection handle configured for a manual control of the tubular cutting head in an operable communication with the suction assembly, and a tissue-separation chamber to avoid a clogging of a tissue removal system for a discectomy; wherein,
the tissue separation chamber has
an entry port for the entry of an extracted tissue into the chamber, the extracted tissue having a solid component and a liquid component, the solid component including a nucleus pulposus tissue;
a baffle to separate the solid component from the liquid component; and,
an exit port for the exit of the liquid component from the chamber;
the tubular cutting head is configured for removing a target tissue of a subject, the cutting head having
an outer perimeter that circumscribes a flow of suction through the cutting head;
a lumen circumscribed by the outer perimeter, the lumen guiding the flow of suction and having a central axis;
a forward cutting blade on a distal edge of the outer perimeter, the forward cutting blade configured for (i) cutting the nucleus pulposus tissue in a forward stroke of the cutting head and (ii) excising and directing entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, the forward cutting blade having a first plane and a second plane, the first plane having a plurality of cutting surfaces and positioned at an angle, ?FP, to the central axis of the lumen of the tubular cutting head; and, the second plane having a plurality of cutting surfaces and positioned at an angle, ?SP, to the central axis of the lumen of the tubular cutting head; and,
a blade guard positioned distal to the forward cutting blade and configured to guard an annulus fibrosis tissue from the forward cutting blade upon the forward stroke, the blade guard having a transverse, cross-sectional width that is at least substantially smaller than the width of a transverse cross-section of the lumen to facilitate the entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, such that the desired entry of the excised nucleus pulposus tissue into the lumen on the forward stroke is reduced by less than 50% due to the presence of the blade guard, the blade guard also being a backward cutting blade configured with a barb to hook nucleus pulposus tissue for removal of the nucleus pulposus tissue in a backward stroke of the cutting head, the guard having a double-edged blade tip pointing back into the lumen at an angle, ?2, of greater than 90° to trap tissue, cut tissue, or trap and cut tissue in the lumen in the backwards stroke of the cutting head;
wherein, the cutting head is configured for an operable communication between the lumen and a source of a suction; and,
the suction assembly is configured for an operable communication with the cutting head, the suction assembly comprising an at least substantially rigid suction tube with a central axis and creating the flow of suction for removing the excised nucleus pulposus tissue through the lumen and out of the subject.

US Pat. No. 10,136,908

COAXIAL COIL LOCK

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing;
an elongated shaft extending distally from the housing and defining a longitudinal axis, the elongated shaft including a flexible portion configured to movably support an end effector such that, bending of the flexible portion is configured to induce pivotal movement of the end effector with respect to the longitudinal axis; and
a locking mechanism coaxially disposed about the flexible portion and selectively rotatable relative to the flexible portion about the longitudinal axis, wherein upon rotation of the locking mechanism about the longitudinal axis in a first direction, the locking mechanism is configured to laterally engage the flexible portion to impede bending of the flexible portion and pivotal movement of the end effector, and wherein upon rotation of the locking mechanism about the longitudinal axis in a second direction, the locking mechanism is configured to laterally disengage from the flexible portion enabling flexure of the flexible portion and pivotal movement of the end effector.

US Pat. No. 10,136,907

METHODS OF LOCATING AND TREATING TISSUE IN A WALL DEFINING A BODILY PASSAGE

COOK MEDICAL TECHNOLOGIES...

1. A delivery device, comprising:a housing having a housing proximal end, a housing distal end, and a housing body defining a housing lumen;
a cannula having a cannula proximal end, a cannula distal end, and a cannula body defining a cannula lumen, the cannula attached to the housing such that the housing lumen and the cannula lumen are in communication;
a pusher having a pusher proximal end, a pusher distal end slidably disposed within the housing lumen, and a pusher body that defines a pusher lumen, the pusher moveable between a pusher first configuration and a pusher second configuration; and
a catheter attached to the pusher and having at least a portion disposed within the cannula lumen, the catheter comprising an elongate member and a balloon, the elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member body defining an inflation lumen in communication with the pusher lumen and an elongate member curve, the balloon disposed on the elongate member and having a wall defining a balloon chamber in communication with the inflation lumen, the balloon moveable between a first deflated configuration and a second inflated configuration as fluid is moved into and out of the balloon chamber, the elongate member adapted to move between a first substantially straight configuration in which the portion of the elongate member that defines the elongate member curve is substantially straight when disposed within the cannula lumen and a second curved configuration when the portion of the elongate member that defines the elongate member curve is free of the cannula lumen.

US Pat. No. 10,136,905

BALLOON CATHETER

ASAHI INTECC CO., LTD., ...

1. A balloon catheter comprising:a balloon;
an outer shaft;
an inner shaft joined to a distal end of the balloon and comprising a coil body; and
a tip having:
a step portion provided on an inner surface thereof and configured to come in contact with a distal end of the inner shaft; and
a proximal end portion that covers an outer periphery of the distal end of the balloon,
wherein:
the distal end of the balloon is sandwiched between the inner shaft and the proximal end portion of the tip,
an outer periphery of the inner shaft has an uneven surface topography, corresponding to the shape of the coil body, at a joining portion in which the distal end of the balloon, the inner shaft, and the tip are joined, and
an inner periphery of the distal end of the balloon at the joining portion has an uneven surface topography corresponding to the uneven surface topography of the outer periphery of the inner shaft.

US Pat. No. 10,136,904

ANKLE REPLACEMENT SYSTEM AND METHOD

Wright Medical Technology...

1. A surgical device, comprising:a body including a handle disposed at a first end and a locking protrusion extending in a direction away from a longitudinal direction of the body, the locking protrusion defining an opening and defining a hole that extends parallel to the longitudinal direction of the body;
a locking tab slidably received within the opening defined by the locking protrusion, the locking tab defining an aperture having first and second portions, the first portion being narrower than the second portion, the locking tab being sized and configured to be received within the opening defined by the locking protrusion of the body;
a pair of spaced apart rails configured to be disposed along a length of the body; and
a plunger rod sized and configured to be received slidably within a threaded hole defined by the handle, the aperture defined by the locking tab, and the hole defined by the locking protrusion, wherein the plunger rod comprises a handle at a proximal end and a shoulder having an enlarged diameter along a length of the plunger rod with a threaded portion adjacent to the shoulder, the threaded portion configured to engage the threaded hole defined by the handle, the plunger rod further comprising a reduced diameter region adjacent to a distal end of the plunger rod, the reduced diameter region having a diameter that is sized and configured to be received within the first portion of the aperture defined by the locking tab for locking the plunger rod in a retracted position,
wherein the surgical device is configured to be coupled releasably to a first implant component and to guide a second implant component into position with respect to the first implant component.

US Pat. No. 10,136,903

TOURNIQUET AND METHOD THEREOF HAVING COMPLIANCE LOGGING AND ALERT FEATURES, AND A SYSTEM THEREOF

Patrick James Lynch, Haw...

1. A tourniquet for blood constriction using a strap and a clasp connected to the strap, which is adjustably configured, and communicable with an external communication apparatus configured to transmit a logging confirmation signal to the tourniquet confirming a successful logging of compliance, the tourniquet comprising:a controller;
an indicator connected to the controller;
a first sensor connected to the controller; and
a housing containing the controller and the first sensor,
wherein the housing includes a receptacle configured to receive the clasp,
wherein the first sensor is configured to output a first signal when the clasp is inserted into the receptacle, and
wherein the controller comprises:
a first communication interface configured to communicate with the external communication apparatus;
a memory; and
a processor configured to execute:
a first determining task that determines whether the clasp has been inserted in the receptacle based on whether the first signal is received;
a first communication task that controls the first communication interface to initiate communication with the external communication apparatus upon the first determining task determining that the clasp has been inserted; and
an alerting task that controls the indicator to alert a user confirming whether the compliance has been satisfied.

US Pat. No. 10,136,902

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:a proximal end including a tool engagement surface; and
a distal end configured to form a threaded bore in vertebral tissue to receive an implant that is separate from the surgical instrument, the distal end including a first thread, a second thread spaced from the first thread and at least one tissue depth indicia, the first thread having a maximum length that is greater than a maximum length of the second thread, the distal end comprising a tapered tip, the second thread being positioned between the first thread and the tip, the first thread having a major diameter that is equal to a major diameter of the second thread, the first thread including a first lead and the second thread including a second lead, the leads being different.

US Pat. No. 10,136,899

CLAMP FOR USE WITH A CUTTING DEVICE

PRICE INVENA APS, Copenh...

1. A clamp comprising:a first leg having an inner face comprising a clamping bed,
a second leg attached at one end to the first leg at one end of said clamping bed by a resilient hinge by which the legs are sprung apart, said second leg having an inner face comprising a clamping bed extending part of the length of the inner face of said second leg from the hinge attached end of said second leg, and a recessed section extending from the clamping bed of said second leg to an opposite end of said second leg;
a third leg attached to said first leg at an opposite end of said clamping bed of the first leg by a resilient hinge by which the third and first legs are sprung apart, said third leg comprising a clamping bed extending the length of an inner face of said third leg, and a contact section on an outer face of said third leg;
wherein said first leg, said second leg and said third leg together form a cavity capable of receiving an object to be clamped,
wherein pressing said second leg towards the first leg against the resilience of the hinge joining them causes said recessed section of the second leg to contact said contact section on said third leg such that said third leg is pressed towards the first leg against the resilience of the hinge joining them,
wherein said recessed section is recessed such that said third leg fits into said recessed section when said clamp is closed,
wherein the clamping beds of said second and third legs together form a contiguous clamping bed for clamping a received object against the clamping bed of the first leg when said clamp is closed, and
wherein said first leg is parallel to said second and third legs when said clamp is closed.

US Pat. No. 10,136,897

EXPANDABLE VASO-OCCLUSIVE DEVICES HAVING SHAPE MEMORY AND METHODS OF USING THE SAME

Boston Scientific Scimed,...

1. A vaso-occlusive device comprising an elongated device portion and one or more expandable components which comprise a shape memory material and which expand laterally outward from the elongated device portion upon being subjected to an increase in temperature from below a thermal transition temperature of the shape memory material to above the thermal transition temperature of the shape memory material.

US Pat. No. 10,136,893

ENDOVASCULAR ANASTOMOTIC CONNECTOR DEVICE, DELIVERY SYSTEM, AND METHODS OF DELIVERY AND USE

CircuLite, Inc., Teaneck...

1. A delivery system comprising:an anastomotic connector including:
a vascular conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the vascular conduit is configured to reside within a vascular structure; and
a supply conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the distal end of the supply conduit forms a bifurcation joint with the vascular conduit and the proximal end of the supply conduit is configured to extend from the vascular structure and couple to an auxiliary device; and
a delivery subassembly, the delivery subassembly having an assembled position including:
a multi-lumen hub having a first lumen and second lumen;
a multi-lumen delivery shaft including a first lumen and a second lumen, the multi-lumen delivery shaft extending through the first lumen of the multi-lumen hub then through the lumen of the supply conduit, through the lumen of the distal end of the vascular conduit, and distally from the distal end of the vascular conduit; and
a secondary delivery shaft extending through the second lumen of the multi-lumen hub then into the proximal end of the vascular conduit, through the lumen of the vascular conduit, and distally from the distal end of the vascular conduit, wherein a distal portion of the secondary delivery shaft extending distally from the distal end of the vasculature conduit and is received by a distal portion of the first lumen of the multi-lumen delivery shaft extending distally from the distal end of the vascular conduit.

US Pat. No. 10,136,891

NATURALLY DERIVED BIOABSORBABLE POLYMER GEL ADHESIVE FOR RELEASABLY ATTACHING A STAPLE BUTTRESS TO A SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

11. A surgical stapler end effector, the end effector comprising:(a) a staple cartridge, wherein the staple cartridge comprises a deck;
(b) an anvil, wherein the anvil is movable from an open position toward the staple cartridge to reach a closed position, wherein the anvil includes an underside;
(c) a buttress assembly, wherein the buttress assembly comprises:
(i) a buttress body, and
(ii) an adhesive material, wherein the adhesive material is configured to removably secure the buttress body to the deck of the staple cartridge or the underside of the anvil; and
(d) a retainer, wherein the retainer is configured to releasably hold the buttress body and wherein the retainer includes an injection port that is configured to receive a syringe needle to thereby permit injection of the adhesive.

US Pat. No. 10,136,890

STAPLE CARTRIDGE COMPRISING A VARIABLE THICKNESS COMPRESSIBLE PORTION

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:an anvil, comprising a longitudinal row of first forming pockets and a longitudinal row of second forming pockets;
a firing member comprising a first cam and a second cam, wherein said first cam comprises a resilient pad, and wherein said second cam is configured to engage said anvil;
a staple cartridge, wherein said staple cartridge is movable relative to said anvil between a first position and a second position, and wherein said staple cartridge comprises:
a cartridge body, comprising:
a deck, comprising:
a longitudinal slot;
a first deck surface positioned on a first side of said longitudinal slot; and
a second deck surface positioned on a second side of said longitudinal slot;
a bottom portion positioned opposite said deck;
a proximal end;
a distal end;
a longitudinal row of first staple cavities extending between said proximal end and said distal end, wherein said first forming pockets are positioned relative to said first staple cavities when said staple cartridge is in said second position; and
a longitudinal row of second staple cavities extending between said proximal end and said distal end, wherein said second forming pockets are positioned relative to said second staple cavities when said staple cartridge is in said second position, and wherein each said first staple cavity and said second staple cavity comprises an opening in said deck;
a metal support extending under said bottom portion, wherein said metal support comprises a bottom cam surface configured to be engaged by said first cam of said firing member to position said cartridge body relative to said anvil;
a plurality of first staple drivers movable between an unfired position and a fired position, wherein each said first staple driver comprises a first support cradle, and wherein a first distance is defined between each said first support cradle and a said first forming pocket when said first staple drivers are in said unfired position;
a plurality of second staple drivers movable between an unfired position and a fired position, wherein each said second staple driver comprises a second staple support cradle, wherein a second distance is defined between each said second support cradle and a said second forming pocket when said second staple drivers are in said unfired position, and wherein said first distance is different than said second distance;
a plurality of first staples, wherein each said first staple is positioned in a said first staple cavity and supported by a said first support cradle, and wherein said first staples comprise a first unformed height;
a plurality of second staples, wherein each said second staple is positioned in a said second staple cavity and supported by a said second support cradle, wherein said second staples comprise a second unformed height, and wherein said first unformed height is different than said second unformed height;
a first tissue thickness compensator, wherein said first tissue thickness compensator comprises polyglycolic acid, wherein said first tissue thickness compensator extends across said longitudinal slot between said first deck surface and said second deck surface, wherein said first tissue thickness compensator comprises a first portion on a first side of said longitudinal slot and a second portion on said first side of said longitudinal slot, wherein said first portion is positioned closer to said longitudinal slot than said second portion, wherein said first portion is aligned with said first staple cavities and is configured to be captured within said first staples along with tissue having a variable thickness, wherein said second portion is aligned with said second staple cavities and is configured to be captured within said second staples along with tissue having a variable thickness, and wherein said first portion is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a first proximal anchor; and
a first distal anchor, wherein said first proximal anchor and said first distal anchor are configured to releasably hold said first tissue thickness compensator to said cartridge body, and wherein said first proximal anchor and said first distal anchor are configured to be incised to release said first tissue thickness compensator from said cartridge body;
a second tissue thickness compensator, wherein said second tissue thickness compensator comprises polyglycolic acid, wherein said second tissue thickness compensator is configured to be captured within said first staples and said second staples along with the tissue having a variable thickness, and wherein said second tissue thickness compensator is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a second proximal anchor;
a second distal anchor, wherein said second proximal anchor and said second distal anchor are configured to releasably hold said second tissue thickness compensator to said anvil, and wherein said second proximal anchor and said second distal anchor are configured to be incised to release said second tissue thickness compensator from said anvil; and
a joint configured to rotatably connected said staple cartridge to said surgical instrument.

US Pat. No. 10,136,889

SYSTEMS AND METHODS FOR CONTROLLING A SEGMENTED CIRCUIT

Ethicon LLC, Guaynabo, P...

1. A powered surgical instrument, comprising:a housing;
a shaft extending from said housing;
an end effector extending from said shaft, wherein said end effector is configured to perform at least one end effector function;
a power source;
a segmented circuit configured to control said powered surgical instrument, wherein said segmented circuit comprises:
a processor segment; and
a motor segment comprising a motor;
a voltage converter configured to supply a first voltage from said power source to said processor segment and a second voltage from said power source to said motor segment, wherein said first voltage and said second voltage are different;
a current sensor configured to measure current within said motor segment; and
a boost converter configured to increase said first voltage to said processor segment when said current exceeds a predetermined value in said motor segment.