US Pat. No. 10,478,156

IMAGING APPARATUS FOR DIAGNOSIS, METHOD OF CONTROLLING THE SAME, PROGRAM, AND COMPUTER READABLE STORAGE MEDIUM

TERUMO KABUSHIKI KAISHA, ...

1. An imaging apparatus for diagnosis accommodating an imaging core which has an optical transceiver for transmitting light from a light source toward a vascular tissue and for receiving reflected light from the vascular tissue, and reconstructing a blood vessel image based on interference light data obtained by converting into an electric signal interference light in which measurement light obtained by rotating the imaging core by using a catheter which has an open hole at a distal end portion and reference light separated from the light from the light source are synthesized, the imaging apparatus for diagnosis comprising:line data generation means for generating line data in a radial direction from a rotary center position of the imaging core based on the interference light data;
determination means for determining whether or not a foreign substance other than a predetermined liquid enters between the imaging core and an inner surface of the catheter based on distribution of signal strength values in the line data which is generated by the line data generation means; and
display means for displaying a message which indicates that entrance of the foreign substance is detected in a case where a determination result of the determination means indicates the entrance of the foreign substance.

US Pat. No. 10,478,152

ENDOSCOPE APPARATUS

FUJIFILM Corporation, To...

1. An endoscope apparatus comprising:an insertion part configured to be inserted into a body; an operation part continuously provided on a proximal end side of the insertion part;
a forceps elevator which is erectably provided to a distal end part of the insertion part, has an erecting motion range from a minimum angular position where the forceps elevator is most reclined to a maximum angular position where the forceps elevator is most erected, and is configured to guide a treatment tool led out from the distal end part;
an operation wire coupled at one end with the forceps elevator and which is inserted into the insertion part; and
an erecting operation lever provided to the operation part, coupled to the other end of the operation wire, and configured to operate the operation wire to erect the forceps elevator;
a first elevator restricting surface configured to restrict the forceps elevator to the minimum angular position in the erecting motion range;
a second elevator restricting surface configured to restrict the forceps elevator to the maximum angular position in the erecting motion range;
a first operation lever restricting surface provided in the operation part, and configured to restrict the erecting operation lever to one end position on a side the forceps elevator is reclined in an entire operating range where the erecting operation lever is operable; and
a second operation lever restricting surface provided in the operation part, and configured to restrict the erecting operation lever to the other end position on a side the forceps elevator is erected in the entire operating range where the erecting operation lever is operable,
wherein an index is disposed on the operation part between the operation part and the erecting operation lever such that the index is entirely shielded by the erecting operation lever when the forceps elevator is in the minimum angular position, and such that the index is exposed when the forceps elevator is in a position in which the forceps elevator is erected from the minimum angular position,
wherein, when an intermediate position is defined between the one end position and the other end position in the entire operating range of the erecting operation lever, the erecting operation lever has: a first operating range being a range between the one end position and the intermediate position; and a second operating range being a range between the intermediate position and the other end position,
wherein, the operation wire has a length such that the forceps elevator is movable from the minimum angular position to the maximum angular position when the erecting operation lever is operated from the one end position to the intermediate position in the first operating range in a state where the treatment tool is not led out from the distal end part,
wherein, the second operating range is a range enabling to position the forceps elevator at the maximum angular position by operating the erecting operation lever from the intermediate position toward the other end position, when the forceps elevator is positioned at an angular position smaller than the maximum angular position even though the erecting operation lever is operated and reaches the intermediate position in a state where the treatment tool is led out from the distal end part.

US Pat. No. 10,478,151

SYSTEM AND METHOD FOR AUTOMATED MONITORING OF FETAL HEAD DESCENT DURING LABOR

GENERAL ELECTRIC COMPANY,...

1. A method for automatically monitoring fetal head descent in a birth canal, comprising:acquiring, via at least one processor, one or more transperineal ultrasound images corresponding to a birth canal of a patient in labor such that the one or more transperineal ultrasound images comprise at least two structures of interest;
segmenting, via the at least one processor, each of the one or more transperineal ultrasound images into a plurality of neighborhood components;
determining, via the at least one processor, a cost function corresponding to each neighborhood component in the plurality of neighborhood components in each of the one or more transperineal ultrasound images;
identifying, via the at least one processor, the at least two structures of interest in each of the one or more transperineal ultrasound images based on the cost function, wherein the at least two structures of interest comprise a pubic ramus and a fetal head;
measuring, via the at least one processor, an angle of progression between a first line passing through the pubic ramus and a second line extending from an inferior apex of the pubic ramus and tangentially intersecting a contour of the fetal skull;
determining, via the at least one processor, the fetal head descent in the birth canal based on the angle of progression to automatically monitor progression of the fetal head in the birth canal of the patient during labor; and
visualizing the one or more transperineal ultrasound images, the pubic ramus, the fetal head, a tangent point on the fetal head, the angle of progression, the fetal head descent, or combinations thereof on a display, wherein at least the angle of progression is overlaid on the one or more transperineal ultrasound images,
wherein the steps of acquiring the one or more transperineal ultrasound images, segmenting each of the one or more transperineal ultrasound images, determining the cost function, identifying the at least two structures of interest, measuring the angle of progression, determining the fetal head descent, and visualizing are automated steps.

US Pat. No. 10,478,147

CALIBRATION APPARATUS AND METHOD FOR COMPUTED TOMOGRAPHY

NIKON METROLOGY NV, Leuv...

1. A method of calibrating a radiographic system comprising a source and a detector, the method comprising:providing a calibration object comprising a plurality of markers,
rotating the calibration object relative to the source and/or detector,
acquiring a plurality of radiographic images of the calibration object,
identifying the plurality of markers in the plurality of images,
deriving an elliptical path for each of the plurality of markers using said plurality of images by
assigning a nominal value representing a distance between the source and an axis of rotation of each said marker, and
determining complete geometrical parameters of the system apart from said nominal distance value using the radiographic images and said nominal distance value,
where said complete geometrical parameters are seven parameters including two parameters specifying a principal point, one parameter specifying a focal length, two parameters specifying the orientation of the axis of rotation and two parameters specifying the position of the axis of rotation, and using said elliptical paths to determine geometrical parameters of the system.

US Pat. No. 10,478,142

METHOD AND APPARATUS OF SPECTRAL DIFFERENTIAL PHASE-CONTRAST CONE-BEAM CT AND HYBRID CONE-BEAM CT

University of Rochester, ...

1. A method of cone beam CT imaging of a human breast without penetrating the chest cavity of a patient, comprising:acquiring projection images of the breast taken at different view angles by using a polychromatic x-ray source irradiating the breast but not the chest cavity with primary radiation, an energy-resolving detector having a plurality of energy channels, and a grating system;
said acquiring comprising acquiring, for each of the plurality of energy channels of the detector, a respective plurality of the projection images of the breast taken at different view angles;
performing three-dimensional (3D) computed tomography reconstructions of the breast for each of the plurality of energy channels to produce a respective plurality of differential phase contrast 3D reconstruction images; and
combining the plurality of differential phase 3D reconstruction images to thereby produce one or more output images of the breast;
wherein said combining of the plurality of differential phase 3D reconstruction images comprises assigning different weights to the images being combined.

US Pat. No. 10,478,140

NEAREST AVAILABLE ROADMAP SELECTION

KONINKLIJKE PHILIPS N.V.,...

1. A system for vascular roadmapping comprising:an imaging device having an x-ray source and an x-ray detector, for generating a fluoroscopy image;
a data base including contrast-enhanced images, wherein the contrast-enhanced images are generated with different imaging parameters;
a user interface configured to select intended imaging parameters; and
a processor configured:
to determine current imaging parameters of the imaging device,
to determine a contrast-enhanced image out of the contrast-enhanced images generated with respective imaging parameters, wherein the contrast-enhanced image has imaging parameters closest to the intended imaging parameters,
to select the contrast-enhanced image to obtain a selected contrast-enhanced image,
to adjust the current imaging parameters of the imaging device to the imaging parameters of the selected contrast-enhanced image, and
to determine that a state of the imaging device is a ready-for-use-state based on a completion of an adjustment of the current imaging parameters of the imaging device from the current imaging parameters to the imaging parameters of the selected contrast-enhanced image,
wherein the imaging parameters of the selected contrast-enhanced image comprises a position of the x-ray source and the x-ray detector, an orientation of the x-ray source and the x-ray detector, settings of the x-ray source, and settings of the x-ray detector, and
wherein the user interface is further configured to indicate the ready-for-use-state or the not-ready-for-use-state of the imaging device.

US Pat. No. 10,478,138

RT-CT INTEGRATED DEVICE

SHENYANG NEUSOFT MEDICAL ...

1. A radiation therapy computed tomography (RT-CT) integrated device comprising a radiation therapy (RT) device and a computed tomography (CT) device, wherein,a radiation-therapy centerline of the radiation therapy (RT) device and a scanning centerline of the computed tomography (CT) device are on a same axis,
the radiation therapy (RT) device and the computed tomography (CT) device are at a same end of a treatment table;
the radiation therapy (RT) device and the computed tomography (CT) device are integrated onto a support system;
the support system comprises a support base provided with a mounting portion,
the computed tomography (CT) device comprises a computed tomography (CT) device rotatable gantry,
the radiation therapy (RT) device comprises a radiation therapy (RT) device rotatable gantry,
the computed tomography (CT) device rotatable gantry is provided with a computed tomography (CT) device ray emitter and a computed tomography (CT) device ray receiver,
the radiation therapy (RT) device rotatable gantry is provided with a radiation therapy (RT) device ray emitter,
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both socket-jointed on the mounting portion, and are disposed coaxially with the mounting portion,
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both fixed in an axial direction and a radial direction;
the computed tomography (CT) device rotatable gantry and the radiation therapy (RT) device rotatable gantry are both rotatable along a circumferential direction;
the radiation therapy (RT) device rotatable gantry, the computed tomography (CTS) device rotatable gantry and the mounting portion are socket-jointed sequentially in the axial direction,
each socket-joint for connecting the radiation therapy (RT) device rotatable gantry, the computed tomography (CT) device rotatable gantry and the mounting portion sequentially is fixed in the axial direction and the radial direction; and
each socket-joint for connecting the radiation therapy (RT) device rotatable gantry, the computed tomography (CT) device rotatable gantry and the mounting portion sequentially is rotatable along the circumferential direction.

US Pat. No. 10,478,134

SYSTEMS AND METHODS FOR IMPROVED DIAGNOSTICS FOR NUCLEAR MEDICINE IMAGING

GENERAL ELECTRIC COMPANY,...

1. A method comprising:defining an uncertainty model of a medical imaging system, wherein the uncertainty model is based on a natural-statistics distribution of the medical imaging system;
acquiring image data of a patient from the medical imaging system;
calculating an uncertainty map of the patient based on the uncertainty model and the image data, wherein the uncertainty map represents a collection of realizations that are generated based on the image data and the uncertainty model; and
applying a classification or ranking algorithm to the image data and the uncertainty map to calculate image data classification or ranking of the patient including confidence values,
wherein the realizations are based on simulations of selections from the uncertainty model, the simulations automatically randomize parameters of the medical imaging system to select different image voxel values.

US Pat. No. 10,478,129

METHODS FOR IMPROVING RESPONSE TIME, ROBUSTNESS AND USER COMFORT IN CONTINUOUS ESTIMATION OF BIOPHYSIOLOGICAL RATES

SAMSUNG ELECTRONICS CO., ...

1. An apparatus for determining a biophysiological feature, the apparatus comprising:a memory having machine instructions stored therein;
a processor coupled to the memory;
a biophysiological sensor coupled to the processor, the biophysiological sensor configured for application to a patient and operable for detecting signals in the patient associated with measuring a quasiperiodic function; and
an input/output device;
wherein the processor executes the machine instructions to:
receive a quasiperiodic data stream for the measured quasiperiodic function from the biophysiological sensor,
remove at least a portion of an offset from the quasiperiodic data stream to provide a smoothed data stream by filtering the quasiperiodic data stream through a bandpass filter and phase compensating the filtered quasiperiodic data stream,
transform the smoothed data stream into an analytic data stream using a Hilbert transform approximation,
calculate a time derivative associated with a phase angle of the analytic data stream,
provide, to a user via the input/output device, an output data stream derived from a frequency, wherein the frequency is the time derivative of the quasiperiodic data stream and wherein the output data stream comprises the biophysiological feature, and
mask the output data stream while a sensor motion fault is detected.

US Pat. No. 10,478,122

MEASUREMENT METHOD AND MEASUREMENT DEVICE FOR BROWN ADIPOSE TISSUE

TOKYO MEDICAL UNIVERSITY,...

1. A measurement method for brown adipose tissue, comprising:a light input step of inputting near-infrared light from a light input unit into a measurement target portion;
a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit;
a calculation step of measuring any one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit;
a defining step in which an index value for a brown adipose tissue amount is defined as the any one value measured; and
a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

US Pat. No. 10,478,120

MRI-GUIDED INTRAARTERIAL CATHETER-BASED METHOD FOR PREDICTING TERRITORY OF LOCAL BLOOD BRAIN BARRIER OPENING

The Johns Hopkins Univers...

1. A method of administering a therapeutic agent directly to the brain parenchyma through a compromised region of the blood-brain barrier in a subject having a brain disorder, comprising:disrupting the blood-brain barrier (BBB) at an isolated region by locally administering an effective amount of a hyperosmolar agent at said region using a catheter,
locating an opening in the BBB using non-invasive MR (magnetic resonance) imaging with a contrast agent administered at said isolated region, and
administering a therapeutically effective amount of a therapeutic agent at the located opening in the BBB.

US Pat. No. 10,478,112

ENHANCING DIAGNOSIS OF DISORDER THROUGH ARTIFICIAL INTELLIGENCE AND MOBILE HEALTH TECHNOLOGIES WITHOUT COMPROMISING ACCURACY

President and Fellows of ...

1. A computer-implemented method for evaluating an individual for a behavioral disorder, a developmental delay, or a neurological impairment; said method comprising:(a) displaying a plurality of questions relating to said behavioral disorder, said developmental delay, or said neurological impairment;
(b) receiving an input comprising a response to at least one of said plurality of questions;
(c) generating an output, based on said input, using a software module comprising a classifier trained with data from a plurality of individuals having said behavioral disorder, said developmental delay, or said neurological impairment;
wherein said output comprises an indication of whether said behavioral disorder, said developmental delay, or said neurological impairment is present in said individual; and
wherein said output has an accuracy of at least 90%.

US Pat. No. 10,478,107

NON-INVASIVE PHYSIOLOGICAL SENSOR COVER

Masimo Corporation, Irvi...

1. A method of providing a sensor cover for a noninvasive optical physiological sensor, the method comprising:providing a sensor cover comprising:
a first cover portion attachable to the sensor and configured to block at least a portion of light from one or more emitters of the sensor from being received by a detector of the sensor when the sensor is active; and
a second cover portion that protrudes from the sensor to facilitate removal of the sensor cover; and
removably attaching the sensor cover to the sensor,
wherein the sensor comprises:
the one or more emitters configured to emit light; and
the detector configured to receive at least some of the light emitted by the one or more emitters after the light has passed through a tissue site.

US Pat. No. 10,478,106

PROBE, SYSTEM, AND METHOD FOR NON-INVASIVE MEASUREMENT OF BLOOD ANALYTES

1. A measuring probe for non-invasive in vivo measurement of blood analytes by Raman spectroscopy, the measuring probe comprising a housing having a skin engaging surface for engaging a subject's skin, the housing comprising:a first optical system comprising light guiding optics configured to direct source light, as a collimated beam, to the skin engaging surface and further configured to cause penetration of the subject 'skin with said collimated beam, for interacting of the collimated beam with the blood analytes, wherein angles between rays of light in the collimated beam are within a threshold value of 10 degrees; and
a second optical system configured to collect scattered Raman light, obtained from scattering of the collimated beam by the blood analytes, for use in measurement of the blood analytes;
wherein the first optical system is configured to direct the collimated beam at an oblique incidence angle with respect to a normal incidence angle of the skin engaging surface; and
wherein the second optical system is configured to spatially separate the scattered Raman light from a specular reflection of the collimated beam from the subject's skin.

US Pat. No. 10,478,102

NEEDLE PROTECTIVE DEVICE FOR SUBCUTANEOUS SENSORS

MEDTRONIC MINIMED, INC., ...

1. A method of covering an introducer needle comprising:providing a sensor hub, a sensor, and an introducer, the introducer being configured to insert the sensor into a patient, the introducer comprising:
a housing detachably connectable to the sensor hub, wherein the sensor hub contains the sensor prior to connection to the housing, the housing including a needle cover, wherein the needle cover is an internal compartment of the housing;
a needle that is moveable with respect to the needle cover and is extendable out of, and retractable into, the housing;
a needle holder connected to the needle and contained within the housing; and
a spring having a top end in contact with the needle holder and a bottom end in contact with the housing,
wherein said needle holder and spring are configured such that, when the housing is connected to the sensor hub, said spring is in a compressed position and the needle extends out of the housing to insert the sensor into the patient, and such that disconnection of the housing from the sensor hub causes said spring to expand, thereby retracting the needle into the housing to be covered by said needle cover inside the housing, and the sensor remaining inserted in the patient;
wherein the housing includes a mating component to mate with the sensor hub and hold said spring in said compressed position when the housing is connected to the sensor hub; and
wherein the mating component includes a lock that locks the needle holder into a needle extended position when the housing is connected to the sensor hub, and when the mating component is not mated with the sensor hub the housing is completely detached from the sensor hub;
connecting the housing to the sensor hub so as to insert the sensor into the patient; and
disconnecting the housing from the sensor hub, whereby the needle cover covers the needle when the housing is detached from the sensor hub.

US Pat. No. 10,478,101

CONTINUOUS GLUCOSE MONITORING BASED ON REMOTE SENSING OF VARIATIONS OF PARAMETERS OF A SIC IMPLANTED ANTENNA

University of South Flori...

1. A passive sensing continuous glucose monitoring system for continuously monitoring a glucose level in a patient or subject, comprising:an external transmitting antenna that is configured to be positioned outside of a body of said patient or subject, said transmitting antenna transmitting a radiofrequency signal into said body of said patient or subject;
a passive internal antenna formed of silicon carbide and including an amorphous silicon carbide insulation, said internal antenna configured to be positioned subdermally in said patient or subject, said internal antenna receiving said radiofrequency signal from said transmitting antenna and configured to reflect said radiofrequency signal out of said body of said patient or subject, wherein a resonant frequency of said internal antenna varies as said blood glucose level in said patient or subject changes;
an external receiving antenna that is configured to be positioned outside of said body of said patient or subject, said receiving antenna receiving said reflected radiofrequency signal from said internal antenna,
wherein said external transmitting antenna and said external receiving antenna are disposed in proximity to each other, and said passive internal antenna is mounted directly towards said external transmitting antenna and said external receiving antenna;
one or more power sources for powering said external transmitting antenna and said external receiving antenna,
wherein said received radiofrequency signal is translated into a measure of said glucose level of said patient or subject;
a display for displaying said measure of said glucose level of said patient or subject.

US Pat. No. 10,478,096

NEURAL EVENT DETECTION

Innovative Surgical Solut...

1. A neural monitoring system for detecting an artificially-induced mechanical response of a muscle to an electrical stimulus provided within an intracorporeal treatment area of a human subject at a stimulation frequency, the intracorporeal treatment area including a nerve that innervates the muscle, the neural monitoring system comprising:a non-invasive mechanical sensor configured to be placed in mechanical communication with the muscle and to generate a mechanomyography output signal corresponding to a sensed mechanical movement of the muscle; and
a processor in communication with the mechanical sensor and configured to:
receive the mechanomyography output signal from the mechanical sensor;
determine a frequency component of the mechanomyography output signal, wherein the frequency component has a peak magnitude relative to adjacent frequencies; and
provide an indication of an artificially-induced mechanical muscle response to a user if the determined frequency component is either equal to, or an integer multiple of the stimulation frequency.

US Pat. No. 10,478,090

SPECTRAL BIN UN-ALIASING FOR REDUCED FIELD-OF-VIEW MAGNETIC RESONANCE IMAGING NEAR METAL IMPLANTS

Medical College of Wiscon...

1. A magnetic resonance imaging (MRI) system comprising:a MRI scanner, including a plurality of radio frequency (RF) receivers, for imaging objects of interest;
at least one processor; and
a memory, with computer code instructions stored thereon, the computer code instructions, when executed by the at least one processor, cause the at least one processor to:
cause the MRI scanner to perform a first scan, on an anatomy region including an implant, according to a first field of view to acquire first multi-spectral MRI data associated with a plurality of frequency bins;
compute, for each pair of a single RF receiver and a single frequency bin, a respective spectral sensitivity map using at least a portion of the first multi-spectral MRI data;
cause the MRI scanner to perform a second scan according to a second field of view to acquire second multi-spectral MRI data associated with the plurality of frequency bins, the second field of view smaller than the first field of view; and
reconstruct one or more MRI images according to the second field of view using the second multi-spectral MRI data and the spectral sensitivity maps.

US Pat. No. 10,478,079

PULSE ESTIMATION DEVICE, PULSE ESTIMATION SYSTEM, AND PULSE ESTIMATION METHOD

PANASONIC INTELLECTUAL PR...

1. A pulse estimation device that estimates a pulse of a subject from information obtained without contact with the subject, the pulse estimation device comprising:a processor;
a memory including instructions that, when executed by the processor, cause the processor to perform operations including:
inputting time-sequential captured images including at least a portion of the subject as an object from a camera;
extracting a skin-color region from each of the captured images;
transmitting a zoom command to the camera that has imaged the captured images or a user of the camera in order to adjust a size of the skin-color region; and
estimating the pulse of the subject based on the skin-color region of the captured images obtained by imaging with the camera, after the zoom command is transmitted,
wherein the operations further include estimating the pulse of the subject based on the captured images before the zoom command is transmitted, and determining whether or not the estimated pulse is stable, and
in a case where the estimated pulse is not stable, transmitting the zoom command.

US Pat. No. 10,478,077

BLOOD PRESSURE METER

OMRON HEALTHCARE Co., Ltd...

1. A blood pressure meter configured to be wrapped around a measurement area having pulsatile properties, the blood pressure meter comprising:a strip-shaped belt that includes a fluid bladder to which a fluid is supplied, wherein the belt is configured to be wrapped around the measurement area;
a main body that is provided on an outer surface side of the belt;
a display device disposed on an outside of the main body;
a pump that is provided inside the main body, and is capable of supplying the fluid to the fluid bladder;
a first fluid path that feeds the fluid from the pump to the fluid bladder or discharges the fluid from the fluid bladder;
a pressure sensor that is incorporated in a sensor package and mounted on a first PCB disposed inside the main body, and is capable of detecting the pressure in the fluid bladder; and
a second fluid path that introduces the fluid from the fluid bladder to the pressure sensor,
wherein the second fluid path includes an inlet pipe that is integrally formed with the sensor package as a circumferential wall of the second fluid path, and extends straight between the fluid bladder and the pressure sensor,
wherein a second PCB, on which a blood pressure measurement device is mounted, is disposed in a space that is located between the first PCB and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction,
wherein the pressure sensor on the first PCB is electrically connected to the blood pressure measurement device on the second PCB, and
wherein the second PCB is disposed within the main body.

US Pat. No. 10,478,074

METHOD FOR DETERMINING PATIENT SUITABILITY FOR A SURGICAL PROCEDURE

1. A method for determining a patient's suitability for a proposed surgical procedure, comprising:producing a patient specific hemodynamic calculation parameter set using the optimizing method comprising:
obtaining a generic hemodynamic calculation parameter set;
producing a measured, first situation, hemodynamic profile of said patient by measuring one or more hemodynamic parameters of said patient in a first situation;
producing a simulated, first situation, hemodynamic profile of said patient, using said generic hemodynamic calculation parameter set, and a hemodynamic simulation module;
comparing said measured, first situation, hemodynamic profile to said simulated, first situation, hemodynamic profile; and
based on said comparison, adjusting said generic hemodynamic calculation parameter set to produce an adjusted, hemodynamic calculation parameter set;
producing a further simulated, first situation, hemodynamic profile of said patient, using said adjusted hemodynamic calculation parameter set and said hemodynamic simulation module;
comparing said measured, first situation, hemodynamic profile to said further simulated, first situation, hemodynamic profile; and
repeating the previous three steps until a sufficiently good agreement is reached between said profiles, then designating the final adjusted hemodynamic calculation parameter set as the patient specific hemodynamic calculation parameter set;
using said patient specific hemodynamic calculation parameter set, and said hemodynamic simulation module, operable on a digital processor, to automatically produce a simulated, procedure specific, hemodynamic profile of said patient; and
evaluating said simulated, procedure specific, hemodynamic profile to determine if said patient is a suitable candidate for said surgical procedure.

US Pat. No. 10,478,067

IMPLANTABLE SENSING DEVICES AND ANCHORING METHODS THEREFOR

Integrated Sensing System...

1. A sensor assembly comprising:a sensing device comprising a housing having at least one internal cavity and a transducer and electrical circuitry within the at least one internal cavity, the sensing device further comprising an antenna that is within the at least one internal cavity or outside the housing, the housing having at least one additional housing portion in which the transducer, the electrical circuitry, and the antenna are not located; and
an anchor for securing the sensing device within a living body, the anchor having an axis, a proximal end, a distal end axially spaced apart from the proximal end, and first and second rings that are axially spaced apart, surround the axis, and define flanges that extend radially from the axis, the anchor having metallic portions and optionally nonmetallic portions, at least one of the first and second rings being a first metallic portion of the metallic portions of the anchor and circumscribing the at least one additional housing portion so as not to surround the transducer, the electrical circuitry, or the antenna, wherein the antenna is not circumscribed by any of the metallic portions of the anchor.

US Pat. No. 10,478,064

DEVICE FOR DETERMINING AN INTRAOCULAR PRESSURE OF AN EYE

INGENEUS PTY LTD., Mt. W...

1. A device for determining an intraocular pressure of an eye of a patient comprising:(a) a housing;
(b) a plunger axially movable within the housing, a first end of the plunger having a tip for contacting the eye;
(c) an indicator arm operatively connected to a second end of the plunger;
(d) a measurement gauge for indicating the intraocular pressure of the eye;
(e) a resilient biasing member having a first end coupled to the indicator arm for biasing the plunger towards an extended position in which the plunger tip protrudes beyond the housing and the indicator arm is biased towards a first position on the measurement gauge; and
(f) a counterbalance for balancing the indicator arm about a pivot such that the device can be used to determine the intraocular pressure of the eye when the plunger is contacting the eye from multiple angles;
wherein applying pressure to the eye via the plunger tip causes the intraocular pressure of the eye to exert an opposing force on the plunger tip causing the plunger to retract into the housing to cause a reciprocal movement of the indicator arm towards a second position thereby indicating the intraocular pressure of the eye on the measurement gauge; and
wherein the gauge and indicator arm are comprised within the housing;
wherein the indicator arm pivots in a plane parallel to the longitudinal axis of housing when pressure is applied to the eye via the plunger tip and the indicator is moving from the first position towards the second position; and
wherein the indicator arm, resilient biasing member, and counterbalance are integrated into a single piece.

US Pat. No. 10,478,062

OPTOMETRY APPARATUS CAPABLE OF MEASURING PARA-CENTRAL DEFOCUS

SUZHOU SEEHITECH EQUIPMEN...

1. An optometry apparatus capable of measuring para-central defocus, comprising a first light source emitting a first light beam, wherein, the optometry apparatus further comprises a diaphragm, a first lens group, a beam splitter, a third lens group, a fourth lens group, a first photoelectric detector, a fixation vision module enabling an eyeball of a subject in a relaxed state, and a scanning module for changing a position of a light spot formed on the retina by the first light beam;wherein, the first light source, the diaphragm, the first lens group, the beam splitter, the third lens group, the fourth lens group and the first photoelectric detector form a diopter measurement module;
the fixation vision module comprises a second dichroic mirror totally transmitting visible light and totally reflecting the first light beam;
the scanning module comprises a first reflecting mirror and a second reflecting mirror which are rotatably positioned in sequence in an emergent optical path of the first light source, the rotation axis of the first reflecting mirror and the rotation axis of the second reflecting mirror form therebetween an angle greater than 0 degree and less than 180 degrees;
the diaphragm, the first reflecting mirror, the first lens group, the second reflecting mirror, the beam splitter and the second dichroic mirror are disposed in the emergent light path of the first light source successively, the third lens group, the fourth lens group and the first photoelectric detector are disposed in a reflected light path of the beam splitter successively.

US Pat. No. 10,478,046

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope, comprising:an insertion section;
a conduit provided inside the insertion section;
a tubular pipe sleeve of a treatment instrument insertion port that is provided in an operation section, the operation section being provided on a proximal end side of the insertion section;
a bent conduit having a bend with a radius such that the conduit communicates with the pipe sleeve; and
a forceps plug that is detachable from the pipe sleeve and includes an opening and a lid,
wherein in a state where the forceps plug is attached to the pipe sleeve, the opening having a center axis offset from a center axis of the pipe sleeve such that the center axis of the opening is eccentric with respect to the center axis of the pipe sleeve in a direction extending outward in a radial direction of the bend in the bent conduit; and
the lid being detachably disposed over the opening and comprising a slit piercing through the lid.

US Pat. No. 10,478,045

FLEXIBLE TUBE FOR AN ENDOSCOPE, ADHESIVE FOR AN ENDOSCOPE, ENDOSCOPE-TYPE MEDICAL DEVICE, AS WELL AS METHOD OF PRODUCING A FLEXIBLE TUBE FOR AN ENDOSCOPE AND METHOD OF PRODUCING AN ENDOSCOPE-TYPE MEDICAL DEVICE

FUJIFILM Corporation, To...

1. A flexible tube for an endoscope, comprising:a tubular flexible tube substrate material having a flexibility; and
a resin layer covering the flexible tube substrate material,
wherein the resin layer is adhered to the flexible tube substrate material with an adhesive hardened,
wherein the adhesive hardened contains an ester-based polyurethane resin, which is a hardened resin of an adhesive for an endoscope,
wherein the adhesive for an endoscope contains an ester-based urethane polymer having a structure represented by the following Formula (1):

wherein R1 and R2 each independently represent an alkyl group, an alkoxy group, an alkylthio group, an aryl group, or a halogen atom; n1 and n2 each independently represent an integer of 0 to 4; X represents —C(Ra)(Rb)—, —O—, —S—, —SO2—, —C(?O)—, or —N(Rc)—; Ra and Rb each independently represent a hydrogen atom, an alkyl group, or an aryl group; Rc represents a hydrogen atom or an alkyl group; and Ra and Rb may be bonded to each other to form a ring, and
wherein a surface material of the flexible tube substrate material is an aramid fiber, and
wherein an equivalent ratio of an urethane segment with respect to a total of an urethane segment equivalent and an ester segment equivalent in the ester-based urethane polymer having a structure represented by the Formula (1) is at least 2% and less than 50%.

US Pat. No. 10,478,037

METHOD FOR OPERATING A FLOOR-CLEANING DEVICE AND FLOOR-CLEANING DEVICE

robart GmbH, Linz (AT)

1. A method for operating a self-propelling and self-steering floor-cleaning device, wherein at least one map of at least one room to be cleaned is stored in a storage unit of the floor-cleaning device, as is a user-predeterminable cleaning plan having one or more cleaning tasks, wherein at least one cleaning task is associated with a particular room that is identifiable from the at least one map, and the floor-cleaning device is placed in a room, the method comprising:when the cleaning plan is executed, analyzing, with a control unit of the floor-cleaning device, at least one sensor signal of a sensor unit of the floor-cleaning device for features indicative of the room the floor-cleaning device is in;
checking for presence of the features in the at least one map stored in the storage unit; and
determining whether the room in which the floor-cleaning device is placed is the particular room;
wherein, if the result of this determination is negative, performance of the cleaning task associated with the particular room is not carried out, is interrupted or is ended.

US Pat. No. 10,478,032

CLEANER

LG Electronics Inc., Seo...

1. A cleaner comprising:a suction unit configured to guide air into the cleaner;
a suction motor that is configured to drive a rotation of a rotary impeller via an impeller shaft to generate a suction force that suctions air into the cleaner through the suction unit, with the rotary impeller disposed at an upper end of the suction motor in a state in which the cleaner is oriented with the impeller shaft arranged longitudinally along a vertical direction;
a dust separation unit that is disposed below the suction motor in the state in which the cleaner is oriented with the impeller shaft arranged longitudinally along the vertical direction, the dust separation unit comprising:
a first cyclone unit that is configured to separate dust from the air that is suctioned into the cleaner; and
a second cyclone unit comprising a plurality of cyclone bodies that are configured to secondarily separate dust from air that is discharged from the first cyclone unit; and
a discharge cover comprising an exhaust filter that is configured to filter air that is discharged from the suction motor, wherein the discharge cover and the exhaust filter are disposed above the rotary impeller in the state in which the cleaner is oriented with the impeller shaft arranged longitudinally along the vertical direction.

US Pat. No. 10,478,030

SURFACE CLEANING APPARATUS

Omachron Intellectul Prop...

1. A surface cleaning apparatus comprising:(a) a surface cleaning head having a front end, a rear end, a dirt air inlet and a cleaning head air outlet;
(b) a rigid air flow conduit having a rigid wand inlet end having an air inlet in communicable with the cleaning head air outlet, a rigid wand outlet end and a longitudinally extending conduit axis, the rigid air flow conduit is moveably mountable to the surface cleaning head between an upright position and an in-use floor cleaning position in which the rigid air flow conduit extends at an angle to the vertical, the rigid wand outlet end having an air outlet and an outlet end electrical connector; and,
(c) a hand vacuum cleaner removably mountable to the rigid wand outlet end, the hand vacuum cleaner having a front end and a rear end, the hand vacuum cleaner comprising:
(i) a main body comprising a handle and a suction motor and fan assembly, the suction motor and fan assembly having a suction motor axis of rotation, the handle having a hand grip portion;
(ii) an air treatment member provided at the front end of the hand vacuum cleaner, the air treatment member having a central longitudinal axis and an air treatment chamber having a front wall;
(iii) a hand vacuum cleaner air inlet centrally positioned with respect to the air treatment chamber front wall and releasably connectable with the air outlet of the rigid wand; and,
(iv) a hand vacuum cleaner electrical connector provided on the front end of the air treatment member adjacent the hand vacuum cleaner air inlet, the hand vacuum cleaner electrical connector is releasably connectable with the outlet end electrical connector,
wherein, when the hand vacuum cleaner is mounted to the rigid wand outlet end, the longitudinally extending conduit axis extends in a same direction as the central longitudinal axis of rotation, and
wherein the hand grip portion has a hand grip portion axis that intersects the suction motor.

US Pat. No. 10,478,028

RECHARGEABLE VACUUM CLEANER ASSEMBLY

JIANGSU MIDEA CLEANING AP...

1. A rechargeable vacuum cleaner assembly, comprising:a rechargeable vacuum cleaner provided with a first magnetic member;
a charging stand provided with a second magnetic member, wherein the first magnetic member is configured to connect with the second magnetic member through magnetic attraction so as to position the rechargeable vacuum cleaner to the charging stand;
a pedal disposed on body of the charging stand and pivotable between a first position and a second position; and
a safety protection device disposed on body of the charging stand and normally engaged with the pedal, wherein when the safety protection device is toggled, the safety protection device is disengaged from the pedal to make the pedal move from the first position to the second position, wherein at least two safety protection devices are provided; the at least two safety protection devices are disposed on the body and spaced apart from each other; when the at least two safety protection devices are toggled, the at least two safety protection devices are disengaged from the pedal to make the pedal move from the first position to the second position;
wherein each safety protection device comprises:
a safety protection member disposed at a side face of the pedal and defining an fitting groove in which an edge of the pedal is fitted; and
a resetting member disposed between the safety protection member and the body, and configured to normally push the safety protection member towards a center of the pedal, wherein the safety protection member is pivotably connected to the body;
wherein the safety protection member has a first end and a second end, in which the fitting groove is defined in the second end of the safety protection member; when the first end of the safety protection member is toggled, the second end of the safety protection member moves away from the center of the pedal to disengage the edge of the pedal from the fitting groove;
wherein the first end of the safety protection member has a guide surface configured to toggle the first end of the safety protection member,
wherein the guide surface is constructed to extend obliquely towards the center of the pedal from up to down; and
wherein the guide surface is formed as an oblique plane or an oblique curved surface, extending obliquely towards the center of the pedal from up to down.

US Pat. No. 10,478,021

UTILITY WASH CLOTH

1. A reusable handheld implement comprised of:a backing, multiple strands and a perimeter;
(A) the backing is flat and made of a water resistant or waterproof material; the mentioned backing is perforated, allowing the backing to be permeable; and where the backing has a thickness that minimizes the volume of said perforations;
and,
(1) the backing is pliable,
(2) perforations are located throughout the backing,
(3) perforations are adjacent to the strands,
(B) the strands are soft and not opened looped; the mentioned strands have an overall smooth surface; the strands are connected to the backing in a manner that allows each strand to have a top end that is vertical or vertically aligned to its bottom end;
and,
(1) the strands are pliable,
(2) the length of each individual strand is not greater than 1 inch,
(3) the diameter of each individual strand is not greater than 1 inch,
(4) the strands are not spaced more than 1 inch apart on any surface of the backing comprised of said strands.

US Pat. No. 10,478,020

SOAP AND WATER DISPENSER FOR A TOILET STALL

1. A touchless soap and water dispenser for a toilet stall, comprising:an internal pair of reservoirs which include a refillable water mister reservoir and a refillable or replaceable soap foam reservoir connected to respective nozzles which extend and protrude from a surface on which the pair of reservoirs are positioned;
a cover that includes a front portion and a rear portion that encapsulate the internal pair of reservoirs in a closed position, the cover having an opening through which at least a portion of the surface associated with the pair of reservoirs is exposed and which further exposes the nozzles that protrude from the surface, the opening extending between the front and rear portions of the cover and on a bottom of the cover, and wherein the front and rear portions of the cover open and close by rotating about a hinge;
a sliding door that is attached to the cover and which is positioned adjacent to the surface associated with the reservoirs, the sliding door moves in a back and forth motion that protects or exposes the nozzles depending on the sliding door's positioning; and
one or more infrared sensors provided in an array around the nozzles which detect approaching and stopping of a hand to dispense soap or water using battery-powered servomotors, and wherein responsive to the hand or other object approaching within a detectable distance to the one or more infrared sensors, the sliding door is activated which covers the recess to protect the nozzles from vandalism or sabotage.

US Pat. No. 10,478,015

SELF-HEATING ASSEMBLY WITH DISTRIBUTED REACTANT

Tempra Technology, Inc., ...

1. A self-heating assembly comprising:a product container for holding a product to be heated;
a heater container coupled to the product container;
a reaction space between the product container and the heater container;
an open cell foam support structure in the reaction space;
a granular second reactant distributed throughout the open cell foam support structure;
a liquid first reactant in the reaction space; and
a frangible membrane in the reaction space configured so that, when intact, it separates the liquid first reactant from the open cell foam support structure and from the granular second reactant,
wherein the liquid first reactant and the granular second reactant are adapted to exothermically react upon contact with one another,
wherein the open cell foam support structure is permeable to the liquid first reactant and is configured to support and substantially maintain the distribution of the granular second reactant throughout the open cell foam support structure before and during the exothermic chemical reaction, and
wherein individual granules of the second granular material have grain sizes that result in the individual granules being supported atop the open cell foam support structure.

US Pat. No. 10,478,010

CODE ARRANGEMENT AND CONTAINER OF SYSTEM FOR PREPARING A BEVERAGE OR FOODSTUFF

Societe des Produits Nest...

1. A method of encoding preparation information, the method comprising:forming a plurality of separate codes on:
a container for a beverage or foodstuff preparation machine, the container for containing beverage or foodstuff material; or
an attachment for attachment to said container or a beverage of foodstuff preparation machine; and
whereby each code at least partially encodes a distinct phase of a preparation process.

US Pat. No. 10,478,006

CAPSULE HOLDER OR AN ADAPTER FOR ADAPTING A CAPSULE IN A CAPSULE HOLDER IN A BEVERAGE PREPARATION MACHINE

Societe des Produits Nest...

1. A capsule holder configured for holding a capsule in a food preparation machine, the capsule being designed for delivering a food product by injection of a fluid under pressure into the capsule when the capsule and capsule holder are inserted into a receptacle of the food preparation machine, the capsule comprising a chamber defined by capsule side walls, a top wall, and a flexible bottom wall, the chamber containing at least one ingredient to be dissolved or extracted by the injection fluid, wherein a beverage dispensing structure comprises at least one dispensing opening disposed through the flexible bottom wall, the capsule holder comprising:a plurality of pillars extending vertically from the flexible bottom wall to an internal wall of the capsule holder to hold the flexible bottom wall at a distance from the internal wall of the capsule holder, and
a pressure retaining element adapted to retain a certain predetermined dissolution or extraction pressure in the chamber for mixing of the injection fluid with the ingredient, the pressure retaining element being located adjacent the flexible bottom wall outside of the capsule, the pressure retaining element comprising at least one protrusion positioned in correspondence to the at least one dispensing opening so that the at least one protrusion is disposed into the at least one dispensing opening corresponding thereto and that the at least one protrusion restricts a cross section of the at least one dispensing opening corresponding thereto, at least at the time the injection fluid inside the chamber presses onto the flexible bottom wall and moves the flexible bottom wall towards the pressure retaining element, wherein the at least one protrusion has a radial cross-sectional shape that differs from a shape of the at least one dispensing opening corresponding thereto, and wherein the at least one protrusion has a general longitudinal profile such that a radial cross section of the at least one protrusion continually increases from apex to base.

US Pat. No. 10,478,000

INSULATED CUP WITH DOUBLE WALL CONSTRUCTION

1. A cup comprising:a cup body made of synthetic resin and having a containing part with an opening being open upward and having a relatively large diameter to be able to receive a beverage or food; and
a cup holder made of synthetic resin and fitted on the cup body from an end opposite the opening of the cup body, with a portion except for an upper end and a lower end thereof spaced a predetermined gap from an outer side of a containing part of the cup body,
wherein the cup body has:
a holder top seat extending downward a predetermined length from the opening and stepped such that a diameter thereof decreases downward, and having an inclined fastening groove having a diameter decreasing upward, on an outer side thereof;
a containing part-inclined surface extending downward from the holder top seat such that a diameter thereof decreases downward, having a containing part for receiving a beverage or food, and having an outer side inclined at a predetermined angle from an upper portion integrally extending from the holder top seat and a lower end forming the containing part; and
three or more anti-sticking protrusions formed with regular angular intervals around an inner side of the containing part at a predetermined distance from the opening of the cup body toward a bottom of the containing part, with the outer side forming the containing part of the cup body maintained at a predetermined angle, in order to support a bottom of a second cup holder inserted in the containing part of the subject cup body when a second cup composed of the second cup holder and a second cup body is stacked, and
the cup holder has:
a pipe-shaped grip inclined with a predetermined length such that a diameter thereof decreases downward, and having an inclined fitting portion formed such that a diameter of an inner side of the cup holder decreases upward to correspond to the inclined fastening groove formed on the outer side of the holder top seat of the cup and to be in close contact with the inclined fastening groove; and
a bottom seating protrusion protruding inward from a lower end of the grip of the cup holder to be in close contact with a lower portion of the cup body and having air holes formed with regular angular intervals so that external air flows between the outer side of the containing part of the cup and the grip of the cup holder.

US Pat. No. 10,477,998

DRINK CUP

Berry Plastics Corporatio...

1. A drink cup comprisesa body including a floor and a side wall coupled to the floor to extend along a central axis away from the floor to define an interior region configured to provide a fluid-holding reservoir,
a brim coupled to the body to locate the side wall between the brim and the floor and configured to define an opening into the interior region, and
a body-strengthening system coupled to the body between the floor and the brim and configured to increase rigidity of a selected portion of the drink cup when compared to a rigidity of the side wall of the drink cup without increasing a weight of the drink cup,
wherein the body-strengthening system includes a first strengthening unit located between a lower portion of the side wall and a middle portion of the side wall and a second strengthening unit located between the first strengthening unit and the brim,
wherein the first strengthening unit includes an upper-strengthening segment and a C-shaped lower-strengthening segment, the upper-strengthening segment is located between the C-shaped lower-strengthening segment and the middle portion of the side wall and the C-shaped lower-strengthening segment is located between the upper-strengthening segment and the lower portion of the side wall,
wherein the upper-strengthening segment is spaced apart from the central axis a first distance and the C-shaped lower-strengthening segment is spaced apart from the central axis a second distance and the second distance is greater than the first distance, and
wherein the second strengthening unit includes a C-shaped annular ring coupled to an upper portion of the side wall and an annular strip extending between and interconnecting the C-shaped annular ring and the middle portion of the side wall.

US Pat. No. 10,477,996

ANTI-SPILL DISPOSABLE DRINK THROUGH CUP LID

11. A disposable straw-and-lid combination comprising:a straw having a diameter; and
a round lid having
a raised top having a full circular circumference,
an outer wall extending down from the full circular circumference of the raised top,
an oval opening in the raised top located adjacent to the full circular circumference, the oval opening spanning at least 0.6 inches,
the raised top having a flat upper surface horizontally extending directly from adjacent the oval opening, around the round lid adjacent to the full circular circumference, and back to adjacent the oval opening,
an unperforated conical structure extending downward from the oval opening in the raised top to a circular opening in the conical structure, the circular opening having a diameter smaller than or equal to the diameter of the straw,
the conical structure having an unperforated side wall that transitions from an oval shape at the oval opening to a circular curvature portion adjacent the circular opening and is configured to guide the straw into the circular opening when the round straw is inserted into the oval opening.

US Pat. No. 10,477,990

DISPLAY STAND

1. A display stand comprising:at least one base sheet, which when assembled forms a base unit, the at least one base sheet being planar and having an outward facing surface, an inward facing surface, and a bottom edge; and
at least one shelf sheet having a shelf surface, the at least one shelf sheet being for attachment to the base unit,whereinthe base unit is assembled by operatively attaching a first section of the at least one base sheet to a second section of the at least one base sheet by way of a first connection means;
the at least one base sheet comprises at least one adjustment line for adjusting the size of the base unit;
the at least one shelf sheet is attached to the base unit by way of at least one second connection means; and
when the at least one shelf sheet is attached to the base unit, the at least one shelf sheet forms a contiguous planar surface around the outward facing surface of the at least one base sheet.

US Pat. No. 10,477,984

UNIVERSAL ACCESSIBLE HOLDER AND DISPENSING UNITS

1. A workplace utensil or condiment holder and dispensing unit, comprising:a. two vertically aligned, L-shaped side walls spaced apart and parallel to each other, each said side wall includes a lower front section and an upper rear section that extends above said lower front section each said L-shaped side wall also includes a rear edge;
b. a vertical rear wall extending transversely between said rear edges of said L-shaped side walls;
c. a lower tier front wall that is substantially parallel to said rear wall, said lower tier front wall extends transversely between said lower front sections of said L-shaped side walls;
d. a bottom panel extending transversely between said L-shaped side walls, said rear wall and said lower tier wall and forms a partially enclosed space inside said holder and dispensing unit;
e. an upper tier front wall that is substantially parallel to said rear wall, said upper tier front wall extending transversely between said upper rear sections of said L-shaped side walls;
f. an intermediate floor panel extending transversely between opposite said L-shaped side walls and between said upper tier front wall and said rear wall, said intermediate floor panel configured to divide said partially enclosed space into an upper tier formed between said upper tier front wall and said rear wall and forms a lower tier formed between said lower tier front wall and said rear wall;
g. at least one lower dividing wall located inside said lower tier and extending from said lower front wall to said rear wall;
h. a braille symbol, an alphabet letter, or a number located on said lower tier front wall or said upper tier front wall that indicates the contents of items placed in said lower tier or said upper tier; and
i. a rear extension extending rearward from said rear wall, said rear extension configured to hold said rear wall away from a vertical wall located behind said holder and dispensing unit and also form a channel behind said rear wall to enable a cable or wire to pass behind said rear wall when said holder and unit is placed on a countertop or table and said rear extension is placed against a wall surface adjacent to said countertop or table.

US Pat. No. 10,477,979

POCKETED SPRING ASSEMBLY

1. A bedding or seating product comprising:a pocketed spring assembly having a uniform height and comprising a plurality of parallel strings of springs including exterior strings and interior strings, each of said strings being joined to at least one adjacent string and being approximately the same height, each of said strings comprising first and second opposed plies of fabric and a plurality of pockets formed along a length of said string by transverse seams joining said first and second plies, and at least one spring positioned in each of said pockets;
each of said springs having upper and lower end turns and a plurality of central convolutions between said end turns, at least one of the central convolutions having a barrel diameter greater than the diameters of the other convolutions of the spring;
the pocketed spring assembly having a perimeter section surrounding an interior section, the perimeter section comprising two side sections and two end sections, each side of the perimeter section being firmer than the core section due to the out-of-pocket characteristics of the springs within the sections, each of the springs of the interior section having an out-of-pocket barrel diameter greater than the out-of-pocket barrel diameter of the springs of the end and side sections and each of the springs of the interior section having a shorter out-of-pocket height than the springs of the end and side sections,
wherein each of said pockets of each of the exterior strings contains an edge spring, each of the edge springs having a first out-of-pocket barrel diameter and a first out-of-pocket height;
each of the interior strings having two different springs, core and edge springs along its length and comprising outer pockets and inner pockets between the outer pockets, each of the inner pockets containing a core spring and each of the outer pockets containing an edge spring, each of the core springs having a second out-of-pocket barrel diameter and a second out-of-pocket height, the first out-of-pocket barrel diameter of the edge springs being less than the second out-of-pocket barrel diameter of the core springs and the first out-of-pocket height of the edge springs being greater than the second out-of-pocket height of the core springs, such that due to the core and edge springs having approximately the same in-pocket height, each of the interior strings having pocketed springs of different firmness, providing the pocketed spring assembly with four sides of edge support, the pocketed edge springs surrounding the pocketed core springs;
cushioning materials; and
a covering encasing said pocketed spring assembly and cushioning materials.

US Pat. No. 10,477,978

MULTI-ZONE TEMPERATURE MODULATION SYSTEM FOR BED OR BLANKET

YOUNGBLOOD IP HOLDINGS, L...

1. A system for temperature-conditioning a surface comprising:an upper layer;
a lower layer;
at least two conduit circuits for directing water through at least two independent temperature zones, wherein the at least two conduit circuits are positioned between the upper layer and the lower layer;
padding positioned between the upper layer and the at least two conduit circuits;
a control unit to selectively heat or cool the water, wherein the control unit consists of one control unit;
wherein the at least two conduit circuits include a first conduit circuit and a second conduit circuit;
wherein the at least two independent temperature zones include a first independent temperature zone and a second independent temperature zone, wherein the first independent temperature zone includes the first conduit circuit and at least one first temperature sensor physically located within the first independent temperature zone operable to measure an actual temperature of the first independent temperature zone, wherein the at least one first temperature sensor is surrounded by the first conduit circuit, and wherein the second independent temperature zone includes the second conduit circuit and at least one second temperature sensor physically located within the second independent temperature zone operable to measure an actual temperature of the second independent temperature zone, wherein the at least one second temperature sensor is surrounded by the second conduit circuit;
wherein the one control unit includes a pump for pumping the water through the at least two conduit circuits, wherein the pump consists of one pump, wherein the one pump includes a first inlet, a second inlet, a first outlet, and a second outlet, wherein the at least two conduit circuits include a first conduit circuit and a second conduit circuit, and wherein a first end of the first conduit circuit is connected to the first outlet of the one pump, a second end of the first conduit circuit is connected to the first inlet of the one pump, a first end of the second conduit circuit is connected to the second outlet of the one pump, and a second end of the second conduit circuit is connected to the second inlet of the one pump;
wherein the one control unit includes a reservoir provided with a thermoelectric device, wherein the reservoir consists of one reservoir, and wherein the thermoelectric device consists of one thermoelectric device operable to provide heating and cooling for the one reservoir;
wherein the at least two conduit circuits are comprised of silicone;
wherein the at least one first temperature sensor is connected to the one control unit and provides the actual temperature of the first independent temperature zone to the one control unit;
wherein the at least one second temperature sensor is connected to the one control unit and provides the actual temperature of the second independent temperature zone to the one control unit;
wherein the one control unit is operable to simultaneously control the flow of the water to the at least two independent temperature zones through the first outlet of the one pump and the second outlet of the one pump or control the flow of the water to the at least two independent temperature zones sequentially through the first outlet of the one pump and the second outlet of the one pump;
wherein the one control unit is operable to maintain a target temperature of the first independent temperature zone and the second independent temperature zone via the simultaneous control or the sequential control of the flow of the water;
wherein the simultaneous control or the sequential control of the flow of the water is governed based on scheduled target temperatures correlating to a sleep cycle of at least one user; and
wherein the at least two independent temperature zones are embedded between the upper layer and the lower layer.

US Pat. No. 10,477,974

OUTDOOR SEATING FURNITURE

1. Outdoor seating furniture that has at least one seating element arranged on a frame with a seat surface and a reverse side,wherein the seat surface is oriented downwards in a stable basic state and the seat surface is oriented upwards in an instable functional state, wherein the seating element is pivotably mounted around the longitudinal axis of a transverse strut of the frame as part of a pivot bearing and is transferred and stabilized by the force of gravity, spring force, magnetic force and/or an electromechanical actuator in the basic state.

US Pat. No. 10,477,971

SOFA SEAT CUSHION CORE

1. A sofa seat cushion, comprising:a cushion core comprising a plurality of pocketed springs enclosed within an upholstery foam envelope and arranged in a spring layer;
at least one memory foam layer positioned above the upholstery foam envelope, at least one polyethylene terephthalate layer positioned above the at least one memory foam layer;
an upholstery-grade polyurethane foam layer positioned below the upholstery foam envelope;
and a polyethylene terephthalate layer directly below the upholstery-grade polyurethane foam layer;
an upper and lower friction barrier positioned above and below the memory foam layer; and
an exterior upholstery surrounding the cushion core.

US Pat. No. 10,477,970

GAS CYLINDER

SAMHONGSA CO., LTD., Seo...

1. A gas cylinder comprising:a base tube comprising a cavity;
a spindle inserted into the cavity and performing a reciprocating motion in a longitudinal direction of the base tube;
a cylinder mounted in the spindle and charged with gas;
a piston dividing the cylinder into an upper chamber and a lower chamber;
a valve portion sealing an upper portion of the cylinder and comprising a pipe holder having a cavity through which the gas is introduced;
a flow prevention portion inserted into the spindle and having an inner surface contacting a surface of the spindle; and
a spindle guide disposed between the base tube and the spindle and mounted to comprise at least a portion of the flow prevention portion;
wherein:
the spindle guide comprises a first mounting portion formed along an inner surface of the spindle guide in a circumferential direction, and a first stopper bump protruding from an inner side wall toward the spindle;
an inner circumferential surface of the flow prevention portion contacts the surface of the spindle, while an outer circumferential surface of the flow prevention portion is spaced apart from the inner side wall of the spindle guide; and
the flow prevention portion moves between a bottom surface of the first mounting portion and the first stopper bump when the spindle reciprocates in a longitudinal direction of the base tube.

US Pat. No. 10,477,967

FURNITURE LEG SOCK

1. A furniture leg protective sock to prevent scraping of a floor by furniture having a furniture leg, the furniture leg having a bottom surface for engaging the floor and a side surface substantially orthogonal to the bottom surface, the sock comprising:expandable non-friction material; and
friction material;
said expandable non-friction material allowing the bottom surface of the furniture leg to slide across the floor;
said expandable non-friction material including,
a top portion having an interior surface, an exterior surface and an opening to slip the sock onto the furniture leg,
a closed bottom portion having an interior surface and an exterior surface, said closed bottom portion covering the bottom surface of the furniture leg when said closed bottom portion engages the bottom surface of the furniture leg, and
a middle portion having an interior surface and an exterior surface, said middle portion extending between said opening of said top portion and said closed bottom portion, said middle portion engaging the side surface of the furniture leg;
said middle portion being substantially orthogonal, when said closed bottom portion and said middle portion engage the furniture leg, to said closed bottom portion;
said friction material being formed on a first portion of said interior surface of said middle portion of said expandable non-friction material;
said interior surface of said closed bottom portion of said expandable non-friction material engaging the bottom surface of the furniture leg;
a second portion of said interior surface of said middle bottom portion of said expandable non-friction material and said friction material formed on said first portion of said interior surface of said middle portion engaging the side surface of the furniture leg;
said friction material formed on said first portion of said interior surface of said middle portion of said expandable non-friction material minimizing, when the furniture leg is moved across the floor, slippage of the sock parallel to the side surface of the furniture leg by providing friction therebetween;
said second portion of the interior surface of the middle portion of the expandable non-friction material being without any of the friction material thereon.

US Pat. No. 10,477,963

MODULAR CABINET ASSEMBLY

Seville Classics Inc., T...

1. A modular cabinet assembly, comprising:a first sub-cabinet and a second sub-cabinet, each sub-cabinet comprising:
a back board having at least two separate back board pieces that are pivotably connected to each other;
a left side board pivotably connected to one of the at least two back board pieces, the left side board having opposite left side board end surfaces and a plurality of pairs of first hook holes provided on the left side board end surfaces; and
a right side board pivotably connected to another of the at least two back board pieces, the right side board having opposite right side board end surfaces and a plurality of pairs of first hook holes provided on the right side board end surfaces;
at least one shelf board having opposite ends removably connected to the left side board and the right side board of either the first sub-cabinet or the second sub-cabinet, each of the at least one shelf board having a bottom and a second hook hole formed on the bottom thereof;
a first end board connected to either an upper end of the first sub-cabinet or a lower end of the second sub-cabinet; and
a plurality of hooks that are adapted to removably connect the at least one shelf board to opposite ends of the left side board and the right side board, wherein each hook has two pairs of first barbs that are received in a pair of first hook holes on either the right side board end surface or the left side board end surface, and a second barb that extends upwardly and is received in the second hook hole.

US Pat. No. 10,477,962

QUICK ASSEMBLY TABLE

Millwork Expressions, Inc...

1. A table, comprising:a horizontal surface with tubular brace members attached thereto;
two or more supporting trusses, each supporting truss comprising a plurality of tubular metal truss members disposed in a planar configuration, said tubular truss members being joined by welding at their abutting ends, and insertable posts welded perpendicularly to said tubular metal truss members, wherein said insertable posts are adapted for insertion into said tubular brace members.

US Pat. No. 10,477,961

FOLDING TABLE

LEKISPORT AG, Baar (CH)

1. A portable table, comprising:a table top and a frame,
wherein the frame comprises two front legs and two rear legs, as well as two front arms and two rear arms,
wherein the front legs and the rear legs have in each case a first, lower free end which is directed toward a support and a second, upper end,
wherein the front arms and rear arms have in each case a second, upper end which is directed toward the table top, and a first, lower end,
wherein the front legs, by way of their second, upper end which is located opposite the first, lower free end, and the front arms, by way of their first, lower end which is located opposite the second, upper end, are fastened on a first, front connecting element,
wherein the rear legs, by way of their second, upper end which is located opposite the first, lower free end and the rear arms, by way of their first, lower end which is located opposite the second, upper end, are fastened on a second, rear connecting element,
wherein the first, front connecting element is connected to the second, rear connecting element by means of at least one first connecting rod,
wherein a first coupling element, which connects a front, left arm to a first longitudinal rod which is arranged parallel to the at least one first connecting rod, is arranged on the second, upper end of the front, left arm and in that a second coupling element, which connects a rear, left arm to the first longitudinal rod, is arranged on the second end of the rear, left arm, and wherein a third coupling element, which connects a front, right arm to a second longitudinal rod which is arranged parallel to the at least one first connecting rod, is arranged on the second end of the front, right arm,
wherein a fourth coupling element, which connects a rear, right arm to the second longitudinal rod, is arranged on the second end of the rear, right arm,
wherein the table top comprises at least one device by which the table top is releasably fastenable on the frame, and
wherein each of the first to fourth coupling elements is formed in an angled and integral manner and comprises a first sleeve portion for receiving a front end or rear end of one of the two longitudinal rods, and comprises a second sleeve portion which is arranged at an angle to the first sleeve portion and is realized for receiving an upper end of an arm of the frame.

US Pat. No. 10,477,957

ORAL CLEANING IMPLEMENT WITH A TOOL ADAPTED FOR REMOVAL OF DENTURE ADHESIVE FROM DENTURES

GlaxoSmithKline Consumer ...

1. An oral cleaning implement comprising a head supporting oral cleaning elements, and an integral handle extending in a longitudinal direction between a proximal end adjacent to the head and a distal end remote from the head;wherein adjacent to the distal end of the handle is a tool adapted for removal of denture adhesive from dentures;
wherein the handle is made of two components being a hard plastic material component and a softer elastomer material component, the tool is made integrally of the material of the softer elastomer material component, and comprises a concavity in the softer elastomer material component adjacent to the distal end of the handle, bounded on at least one widthways side by a ridge made integrally of the softer elastomer material component of the handle; and
wherein the tool comprises a scoop adapted for removal of denture adhesive from dentures.

US Pat. No. 10,477,946

MIRROR FOR APPLYING EYE COSMETICS

MYJF Enterprises, LLC, D...

1. A cosmetic mirror comprising:a base mirror at a surface of a base panel having two long sides and two short sides; and
a three-point reflection path between a first side mirror and a second side mirror at surfaces of a first side panel and a second side panel respectively, the first side panel and the second side panel affixed to opposing parallel edges of the two long sides of the base panel and the first side mirror and the second side mirror each positioned at an obtuse angle relative to the base mirror,
wherein the first side mirror and the second side mirror have a greater than 1× magnification selected according to a width of the base panel and a radius of curvature oriented to provide a distance from the first side mirror and the second side mirror shorter than the focal length.

US Pat. No. 10,477,942

APPLICATOR TIP FOR COSMETIC PRODUCT, ASSOCIATED APPLICATOR AND APPLICATOR ASSEMBLY

ALBEA SERVICES, Gennevil...

1. An applicator tip for cosmetic product, said applicator tip comprising:a fixing part for fixing to a support rod, and
an application part for applying said product,
said application part having at least two opposing rounded applicator faces that are hinged to said fixing part and extend as far as a distal end of the applicator in a main direction of longitudinal extension,
said rounded applicator faces having a radius of curvature of less than 6 mm,
said fixing part comprising a sleeve,
said application part being connected to said sleeve by means of a flexible restriction, such that said application part is rotatable relative to said sleeve about at least two axes of an orthonormal coordinate system,
said restriction being rounded and substantially concave in shape, and when viewed in a plane that is transverse to said main direction, said rounded shape having a radius of curvature of less than 6 mm and wherein said restriction has a circular cross section that is transverse to the main direction, that is substantially circular in shape and the diameter of which is at least equal to 1.5 mm.

US Pat. No. 10,477,939

CUSHION COMPACT CONTAINER

F.S. KOREA INDUSTRIES INC...

1. A cushion compact container comprising:a container main body which is provided with a container body and a cover openably and closably coupled to the container body;
a cosmetic storage unit which is coupled to the container body and stores a cosmetic; and
a cosmetic applicator unit which is coupled to a region of the cover which is opposite to the cosmetic storage unit, and allows a user to apply the cosmetic stored in the cosmetic storage unit so that the user spreads the cosmetic onto the user's face without using the user's hand,
wherein the cosmetic applicator unit is separated from the container body without opening the cover, and the cosmetic storage unit is coupled to the container body so as to be detachable downward from the container body in a state in which the cover is coupled to the container body,
wherein the cosmetic applicator unit includes:
a handle body that is fitted and coupled with an accommodating groove provided in the cover;
a cosmetic applicator member that is coupled to the handle body by means of a fixing member, and the cosmetic applicator member includes a brush to which the cosmetic is attached; and
a collecting unit which is coupled to the handle body so as to be movable upward and downward, and uniformly collects the expanded cosmetic applicator member,
wherein a stopper ring is provided at a lower end portion of the collecting unit,
wherein the collecting unit moves downwardly to a lower portion of the cosmetic applicator member such that the collecting unit collects the cosmetic applicator member and, when the cosmetic applicator unit is coupled to the accommodating groove of the cover, the stopper ring is caught by an annular rim provided within the cover and the collecting unit is raised, and
wherein the collecting unit is disposed between the handle body and the fixing member such that the collecting unit is movable upward and downward within the handle body.

US Pat. No. 10,477,936

INTEGRATED, MANICURE-PEDICURE STATION APPARATUS AND METHOD

1. An apparatus, comprising:a workstation comprising a body and a cushioned non-slip polymer based skin, the body comprising a top surface formed to be substantially flat and inclined upward with progress along a longitudinal direction extending away from a front edge thereof, wherein the polymer based skin covers the top surface of the body, such that the polymer based skin is distinct from a material of the body, and wherein the polymer based skin is chemically resistant and impervious to at least one of alcohol and acetone;
wherein the top surface further extends continuously to form an arcuate cross section region rising and falling vertically with progress longitudinally away from the front edge of the body;
the workstation further comprising a first recess and a second recess, wherein the first recess is within the body and adjacent to the accurate cross section region, wherein the second recess is within the apex of the accurate cross section region, and wherein the first recess and second recess are sized and shaped to support at least one of materials and tools corresponding to at least one of manicure and pedicure; and
the body having a flexible configuration, wherein the flexible configuration is comprised of a lower region of the body folded at an angle relative to an upper region of the body, such that the folded lower region of the body is adapted to abut against an edge of a surface.

US Pat. No. 10,477,935

NAIL LAMP WITH COLOR-CHANGING EXTERIOR LIGHTING AND RECHARGEABLE BATTERY

LeChat, Hercules, CA (US...

1. A nail lamp comprising:an upper housing, wherein the upper housing comprises at least a portion having a translucent material;
a lower housing, coupled to the upper housing, wherein an enclosed space is between the upper and lower housings;
a display panel, wherein the display is capable of displaying at least two digits;
a first printed circuit board, positioned in the enclosed space between the upper and lower housings, wherein the first printed circuit board comprises electronic circuitry comprising a control circuit that is coupled to one or more buttons, accessible from an exterior of the nail lamp, and the display, and
by way of the one or more buttons, a user can select a curing time, which will be displayed on the display panel;
a second printed circuit board, coupled to the first printed circuit board and positioned in the enclosed space between the upper and lower housings, wherein the second printed circuit board comprises a plurality of interior-illuminating light emitting diodes that are coupled to the control circuit of the first printed circuit board,
light emitted by the interior-illuminating light emitting diodes is directed through apertures into a treatment chamber of the nail lamp, and
when on, the interior-illuminating light emitting diodes emit ultraviolet light;
a plurality of exterior-illuminating light emitting diodes, coupled to the control circuit of the first printed circuit board, wherein light emitted by the exterior-illuminating light emitting diodes strikes a surface of the translucent material, visible from the exterior of the nail lamp,
when on, the exterior-illuminating light emitting diodes emit non-ultraviolet light, the interior-illuminating light emitting diodes emit light in a first direction, the exterior-illuminating light emitting diodes emit light in a second direction, and the first direction is toward the treatment chamber and the second direction is away from the treatment chamber, and
while the exterior-illuminating light emitting diodes are on, a color of the light emitted by the exterior-illuminating light emitting diodes changes to be different colors comprising at least red, green, and blue shades.

US Pat. No. 10,477,934

HAIR RETAINING DEVICE AND METHOD OF USING SAME

1. A hair retention device, comprising:a centrally located rod having a proximal end and an oppositely arranged distal end and a given length therebetween;
a pair of elongate helical coils surrounding at least a portion of the length of the centrally located rod, each of the coils in the pair of helical coils having two opposing ends, each coil being attached to the centrally located rod at one end at an attachment point which is located adjacent the proximal end of the rod and having an opposite, free end which is not attached to the centrally located rod;
the pair of elongate helical coils being angularly offset by 180 degrees with respect to a longitudinal axis of the centrally located rod.

US Pat. No. 10,477,933

SMART LUGGAGE SYSTEM WITH CAMERA INSTALLED IN PULL ROD

LINGDONG TECHNOLOGY (BEIJ...

1. A smart luggage system, comprising:a piece of luggage configured to store items for transport;
a handle coupled to the luggage, wherein the handle includes a pull rod coupled to a connecting rod;
an upper camera disposed in a top portion of the pull rod; and
a control button coupled to the luggage or the handle and configured to stop a people following function of the smart luggage system and start a photo/video taking process of the smart luggage system.

US Pat. No. 10,477,924

WINDING DEVICE

JAPANA CO., LTD., Nagoya...

1. A winding device comprising:a first rotation shaft that rotates and drives a first string winding unit;
a second rotation shaft arranged coaxially with the first rotation shaft to rotate and drive a second string winding unit;
a first gear coupled to the first rotation shaft;
a second gear coupled to the second rotation shaft and located at a position opposing the first gear and spaced apart from the first gear;
a sliding gear member arranged between the first and second gears and including a third gear and a fourth gear respectively engaged with the first gear and the second gear;
a handle including a gear accommodation portion that is tubular and has a closed end, and accommodates the first gear, the second gear, and the sliding gear member;
an inclined groove formed in an inner surface of the gear accommodation portion and extending in the inner surface of the gear accommodation portion from an opening of the gear accommodation portion toward the closed end of the gear accommodation portion;
an engagement projection formed on an outer surface of the sliding gear member, wherein the engagement projection engages the inclined groove and is slidable in the inclined groove; and
a lock member that restricts a slidable range of the engagement projection, which is arranged in the inclined groove, from the opening of the gear accommodation portion and restricts separation of the engagement projection from the inclined groove, wherein
a change in a rotation direction of the handle moves the sliding gear member in an axial direction of the first and second rotation shafts and switches the gear engaged with and rotated and driven by the gear of the sliding gear member between the first gear and the second gear.

US Pat. No. 10,477,910

FLEXIBLE SOLE AND UPPER FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A midsole for an article of footwear, the midsole comprising:a midsole body comprising a toe portion, a midfoot portion, and a heel portion;
a first surface and a second surface opposite the first surface, the midsole body extending between the first surface and the second surface; and
a plurality of sipes extending from the first surface into the midsole body, the plurality of sipes comprising:
a plurality of arcuate sipes extending longitudinally, wherein the plurality of arcuate sipes comprises a first arcuate sipe having a first length extending from the toe portion to the heel portion, an intermediate arcuate sipe having a second length that is shorter than the first length, and a plurality of shorter arcuate sipes each having a third length that is shorter than the second length, and
a first diagonal sipe and a second diagonal sipe, the first diagonal sipe intersecting the second diagonal sipe,
wherein the first arcuate sipe intersects the first diagonal sipe and the second diagonal sipe at a location in which the first diagonal sipe intersects with the second sipe,
wherein the intermediate arcuate sipe, the plurality of shorter arcuate sipes, and at least a portion of the first arcuate sipe are parallel to a curvature of a lateral edge of the midsole.

US Pat. No. 10,477,906

WINGED CAPE FOR CHILDREN'S PLAY

1. A winged cape for wearing by a person, comprising:a flexible inner web and a flexible outer web, each web sharing a common outline representing a pair of wings, each web mutually fixed at least along their common outline, each web having a top edge and at least one side edge;
at least four parallel arm slots formed through the inner web to define sleeves generally orthogonal to a longitudinal axis of each web, the sleeves mutually coaxially aligned and integrally formed with the inner web;
whereby when worn each arm of the person positioned through one of the arm sleeves between the arm sleeve and the outer web, the longitudinal axes of the webs are parallel with and aligned with the person's torso, the webs forming the winged cape when worn by the person,
wherein each web is further directly mutually sewn together along at least two additional stitches outside of the sleeves defined between arm slots in the inner web.

US Pat. No. 10,477,902

BREAST SUPPORT GARMENT

LULULEMON ATHLETICA CANAD...

1. A breast support garment comprising:a front panel configured to cover at least a portion of a wearer's chest;
a pair of straps each having a first end connected to the front panel; and
a reinforcing frame comprising
a front reinforcing structure connected to the front panel and defining two breast areas, the front reinforcing structure comprising
a central reinforcing element with two crisscrossing legs configured to extend from a chest region of a first breast to an under-breast region of an opposite breast thus separating the two breast areas,
each of the leg of the central reinforcing element having a top end that is in contact with the first end of the respective strap,
wherein the front reinforcing structure is a single piece with a pre-defined structural property and is configured to support breast tissue directly around a root of each breast.

US Pat. No. 10,477,896

PHOTODETECTOR FOR MEASURING AEROSOL PRECURSOR COMPOSITION IN AN AEROSOL DELIVERY DEVICE

RAI Strategic Holdings, I...

1. An aerosol delivery device comprising:at least one housing enclosing a reservoir configured to retain an aerosol precursor composition;
a heating element controllable to activate and vaporize components of the aerosol precursor composition;
a light source configured to emit light into the reservoir;
a photodetector configured to detect a reflection of the light, wherein the reflection of the light indicates an amount of aerosol precursor composition retained in the reservoir;
a flow sensor configured to detect a flow of air through at least a portion of the at least one housing; and
a control component coupled to the photodetector and configured to control operation of at least one functional element of the aerosol delivery device based on the reflection so detected, and thereby the amount of aerosol precursor composition,
wherein the control component is configured to operate in an active mode to control the heating element to activate and vaporize components of the aerosol precursor composition only when both the flow of air is detected by the flow sensor, and the reflection of the light indicates at least a threshold amount of the aerosol precursor composition.

US Pat. No. 10,477,891

SMOKING SYSTEM AND METHOD UTILIZING SMOKE CLEANSING AND CONDITIONING COMPONENTS

1. A smoking system comprising:a combustion chamber in which a product is combusted resulting in product smoke;
a conduit member connected to the chamber, the conduit member having an upward end and a lower end, wherein the product smoke flows into the conduit member from the chamber and towards the upward end;
an element member supported within the conduit member, wherein the element member is configured to rotate within the conduit member;
a water delivery mechanism which delivers water to the upward end of the conduit member wherein the water is introduced into an internal tube of the element member and dispensed into the conduit member as the element member rotates;
a motor mechanically connected to the element member, wherein the motor provides rotation to the element member; and
a smoke delivery tube attached at the upward end of the conduit member.

US Pat. No. 10,477,878

METHOD FOR MAKING LIQUID OR SEMI-LIQUID PRODUCTS AND MACHINE TO IMPLEMENT THE METHOD

1. A method for making liquid or semi-liquid products, comprising the following steps:providing a machine comprising:
a first processing container for processing a basic liquid or semi-liquid product and defining a processing chamber;
a cooling cylinder mounted inside the first container;
a second processing container;
a rotary stirrer mounted inside the first processing container and inside the processing chamber and outside the cooling cylinder, the rotary stirrer being rotatable about a horizontal axis;
a valve mechanism including:
a shutoff valve positioned and configured to axially move between open and closed positions to respectively open and close a connecting duct between an interior of the second container and the first container;
a further duct connected between the shutoff valve and an actuator including a motor; the further duct axially movable by the actuator along an axis of the further duct to move the shutoff valve between the open and closed positions; the further duct including an upstream end adjacent the actuator, a downstream end adjacent the shutoff valve and an internal longitudinal through cavity between the upstream end and the downstream end;
a one-way valve positioned at the upstream end to allow air into the internal through cavity;
wherein the shutoff valve is actuatable independently of actuation of the rotary stirrer;
a dispensing device operatively connected to the first processing container and configured, in a dispensing configuration, to deliver the liquid or semi-liquid product to an exterior of the machine or, in an inhibiting configuration, to prevent the liquid or semi-liquid product from being dispensed;
placing a basic liquid or semi-liquid product inside the second processing container;
stirring and thermally treating the basic liquid or semi-liquid product inside the second processing container;
transferring the basic liquid or semi-liquid product from the second processing container to the first processing container with the dispensing device in the inhibiting configuration;
stirring and thermally treating the basic liquid or semi-liquid product inside the first processing container;
setting the dispensing device to the dispensing configuration to allow dispensing the liquid or semi-liquid product from the first processing container while inhibiting transfer of the basic liquid or semi-liquid product from the second processing container to the first container.

US Pat. No. 10,477,874

TIDAL ROTATING OYSTER SHAPER AND CLEANER APPARATUS AND METHOD OF USE

1. A tidal rotating oyster shaper and cleaning apparatus configured to rotate by a source of passive energy, said apparatus comprising:an outer frame;
a containment cage supported by the outer frame, said containment cage having two lateral ends;
at least one container configured to hold oysters, said at least one container located and maintained within the containment cage;
a circular end member mounted on each lateral end of the containment cage, said end members each having outwardly extending teeth which circumscribe the end members;
at least one passive energy capturing pawl configured to contact and engage the teeth which circumscribe the end members on the lateral ends of the containment cage;
whereby upon the introduction of a source of passive energy to the apparatus, the pawl is caused to rotate in a first direction, thereby rotating the end members, the containment cage, and said at least one container within the containment cage.

US Pat. No. 10,477,870

PLANT AND METHOD FOR THE TREATMENT OF WHOLE MUSCLE MEAT

1. A plant for the treatment of whole muscle meat including a brine injection apparatus integratinga conveyor device of whole muscle meat defining a conveying direction, and a conveying surface on which said whole muscle meat is to be placed;
three injector heads successive in the conveying direction, each provided with a plurality of injector needles parallel to one another and orthogonal to said conveying surface, wherein each injector head is movable in a direction orthogonal to the conveying surface between an injection position and a standby position away from the conveying surface, and wherein each of said injector needles is hollow and is connected to a pressurized brine supply device; and
wherein said plant also integrates at least one massage application apparatus including a rotary drum suitable for being loaded with the whole muscle meat after it has gone through the injection apparatus; wherein
there are three injector heads;
one injector head, constituting a stand-alone injector head, is connected to a first pressurized brine supply device, being independent from the remaining injector heads which constitute two linked injector heads which reach the injection position at alternating times;
the conveyor device has at least two segments that can be independently operated, the conveying surface of each of said segments facing one of said two linked injector heads; and in that
said rotary drum has an inner face with a maximum inner diameter comprised between 140 cm and 210 cm and is operated by a motor making the drum rotate at between 14 and 20 revolutions per minute;
such that the brine injection occurring in the injection apparatus and the turning occurring in the massage application apparatus allow increasing the weight of the whole muscle meat, with respect to the initial weight before the meat goes through the plant, by up to more than 220% by way of brine absorption.

US Pat. No. 10,477,868

ICING MACHINE AND ICING METHOD

Axis Automation, Hartlan...

1. A machine for simultaneously coating a plurality of items with a coating, each item having a first side and a second side, wherein the plurality of items are placed on the machine in rows which are substantially straight and substantially perpendicular to the direction of travel of the plurality of items through the machine, the machine comprising:a first belt including openings through which the coating can flow;
a first conveyor having a first end and a second end, which moveably supports the first belt such that a top portion of the belt moves in a coating direction, the top portion transitions to a bottom portion of the belt at the second end, the top portion supporting and conveying a plurality of rows of the plurality of items between the first and second ends in the coating direction wherein the plurality of items are supported on the first sides;
a first variable speed drive coupled to the first conveyor to move the top portion in the coating direction;
a pan located between the top and bottom portions of the first belt;
a variable-flow rate icing pump configured to pump the coating into the pan and through the openings to coat the first side of the plurality of items with the coating as the plurality of items move above the pan;
a second belt;
a second conveyor which moveably supports the second belt such that a top portion of the second belt moves in the coating direction;
a second variable speed drive coupled to the second conveyor to move the top portion of the second belt in the coating direction;
a sensor which generates a signal in response to the passing of the plurality of rows of the plurality of items;
a structure which supports the second conveyor relative to the first conveyor such that the coated items drop from the first belt onto the top portion of the second belt such that the coated items are resting upon the second sides after being dropped onto the second belt, the structure further supporting the sensor relative to the top portion of the first belt proximate to the second end;
a controller coupled to the variable speed drives and the sensor, the controller configured to control the first variable speed drive to move the top portion of the first belt at an average speed, and control the second variable speed drive to vary the speed of the second belt in response to the signal generated by the sensor, such that the second belt moves at a drop speed which is below the average speed of the first belt when the coated items are dropped onto the second belt.

US Pat. No. 10,477,863

USE OF HERBICIDAL COMPOSITIONS FOR CONTROLLING UNWANTED VEGETATION

BASF SE, Ludwigshafen am...

1. A method for controlling unwanted vegetation in crop plants, which comprises treating plants, their seeds and/or their habitat with a herbicidal composition comprising as componentA) 4-(2,4-dichlorophenoxy)butanoic acid of formula (I) or salts or esters thereof

and as component
B) 3,6-dichloro-2-methoxybenzoic acid of formula (II) or salts or esters thereof,

wherein the weight ratio of components A) to B) based on acid equivalents is from 1:12 to 1:50.

US Pat. No. 10,477,855

RODENT BAIT STATION HAVING A COUNTING MECHANISM

1. A rodent bait station having a counting mechanism, comprising:a housing, wherein said housing is configured to be fastened to an anchoring surface with a fastener, said housing having at least one opening, said housing having a bait chamber, said bait chamber having at least one bait chamber opening;
a sensor, wherein said sensor is in communication with said at least one bait chamber opening, whereby, said sensor is configured to detect the presence of a rodent passing through said at least one bait chamber opening of said housing;
a counting mechanism, said counting mechanism is in communication with said sensor, said counting mechanism is configured to be activated when said sensor detects the presence of a rodent passing through said at least one bait chamber opening of said housing, said counting mechanism is in communication with a database, said database is configured to retain data associated with the number of times said counting mechanism is activated, said database is in electrical communication with an application program, said application program is in electrical communication with an electronic device, whereby, said application program is configured to be monitored by a user through said electronic device;
a lid, said lid is hingedly connected to said housing;
at least one bait rod, said at least one bait rod having a first end located opposite a second end, said first end of said at least one bait rod is connected to an inner surface of said housing, said second end of said at least one bait rod is configured to receive a bait; and,
a resilient member, said resilient member is in communication with said first end of said at least one bait rod, whereby, said at least one bait rod is positioned in a substantially horizontal orientation when said lid of said housing is closed and said at least one bait rod is positioned in a substantially vertical orientation when said lid of said housing is opened.

US Pat. No. 10,477,850

BEARING HOUSING STRUCTURE AND DUAL-BEARING REEL

Shimano Inc., Osaka (JP)...

1. A bearing housing structure, comprising:a bearing rotatably supporting a spool shaft;
a lid part disposed at an end surface of the spool shaft and extending in a direction that intersects the spool shaft; and
a supporting part housing and supporting the bearing and holding the lid part at the end surface of the spool shaft,
the supporting part including a bearing hole and a lid hole, the bearing hole configured to have the bearing inserted thereinto and removed therefrom in a direction along the spool shaft, and the lid hole configured to have at least a portion of the lid part inserted thereinto and removed therefrom in the direction that intersects the spool shaft and a direction along which the lid part extends, and
the lid part is configured to close an opening of the bearing hole such that the lid part is held by the lid hole of the shaft supporting portion.

US Pat. No. 10,477,847

ROLLER CLUTCH FOR FISHING REEL

Shimano Inc., Osaka (JP)...

1. A roller clutch for a fishing reel, comprising:an outer ring including a radially inner side;
an inner ring disposed on the radially inner side of the outer ring;
a roller disposed between the inner ring and the outer ring, and configured to move between a transmitting position to transmit power between the outer ring and the inner ring and a non-transmitting position to prevent transmission of the power;
a torsion spring configured to bias the roller toward the transmitting position; and
a housing member having a housing hole housing the torsion spring, the housing hole being defined by an inner wall surface, the inner wall surface supporting the torsion spring on an outer surface thereof.

US Pat. No. 10,477,840

POULTRY KEEPING FACILITY WITH ADDITIONAL PERCHING RODS

BIG DUTCHMAN INTERNATIONA...

1. A poultry keeping facility comprising:at least one nest box;
a first colony surface having a perforated first floor area;
a second colony surface having a second floor area for spreading litter;
an actuator coupled to the perch facility; and
a control unit in signal communication with the actuator;
wherein said poultry keeping facility has at least one perching rod arranged at a height above the first or second floor area, said perching rod being movable relative to the first or second floor area by the actuator from a first position to a second position in which the perch facility covers a smaller area of the first or second floor area than in the first position and does not preclude access to the nest box; and
wherein the control unit is configured to move the perching rod the second position to the first position in the evening and from the first position to the second position in the morning.

US Pat. No. 10,477,786

TWO-STAGE AEROPONIC GROWING SYSTEM AND METHOD

Eric John Wilson, North ...

1. A two-stage aeroponic growing system, the system comprising:at least one cylindrical container comprising a generally cylindrical sidewall that forms a generally cylindrical cavity, the cylindrical sidewall defined by a plurality of spaced-apart, elongated side apertures, a closed end defined by a plurality of spaced-apart end apertures, and an open end terminating at a circumferential edge, whereby a rim extending around the circumferential edge of the at least one cylindrical container;
a cylindrical lid defined by a first face, a second face, and a plurality of lid apertures, the cylindrical lid configured to engage the circumferential edge of the at least one cylindrical container, the cylindrical lid further configured to regulate access to the cylindrical cavity of the at least one cylindrical container;
a sloped container comprising a tray that forms at least one drain hole, the tray surrounded by a first wall, a pair of lateral walls and a generally sloped second wall, the walls having an upper free edge, the tray and the walls forming a cavity, further the sloped container comprising at least one fluid supply hole;
a curved lid having a sloped surface and a circumferential edge configured to mount on to the upper edge of the walls of the sloped container, the sloped surface of the curved lid comprises a central horizontal plane surface and a plurality of gradually sloped plane surfaces from both sides of the central horizontal plane surface, whereby each of the gradually sloped plane surfaces are at a predetermined gradient from the adjacent plane surface, further each of the plane surfaces comprises a plurality of rows of evenly, spaced-apart holes which are configured to enable holding at least one cylindrical container, whereby the rim engages the curved lid allowing the at least one cylindrical container fixedly coupled to the sloped container at a predetermined angle; and
at least one nozzle attached to the fluid supply hole of the sloped container, wherein the at least one nozzle is configured to controllably spray a fluid in the cavity of the sloped container.

US Pat. No. 10,477,783

ENVIRONMENT CONTROLLED MULTI SPAN STRUCTURED GREEN HOUSES FOR COST EFFECTIVE FOOD PRODUCTION

1. An environmentally controlled greenhouse having a roof, the greenhouse comprising:a capture manifold for capturing a carbon dioxide rich greenhouse air during dark hours and an oxygen rich greenhouse air during sunlight hours;
a compressor for compressing the captured carbon dioxide rich and oxygen rich greenhouse air;
a first tank (T1) and a second tank (T2) for dehumidifying, or for maintaining relatively dry, the compressed carbon dioxide rich and oxygen rich greenhouse air;
a release manifold for releasing into the greenhouse at cultivation level, the dehumidified or relatively dry carbon dioxide rich greenhouse air during the sunlight hours, and the dehumidified or relatively dry oxygen greenhouse air during the dark hours;
a third tank (Ta) for storing and dehumidifying compressed atmospheric air for release into the greenhouse to maintain a balance between carbon dioxide and oxygen;an earth tube heat exchanger comprising a first compartment (Ec) for storing the dehumidified carbon dioxide rich greenhouse air, a second compartment (Eo) for storing the dehumidified oxygen rich greenhouse air, a third compartment (Ecd) for storing the relatively dry carbon dioxide rich greenhouse air, and a fourth compartment (Eod) for storing the relatively dry oxygen rich greenhouse air, wherein, in relatively cold weather geographical locations, the earth tube heat exchanger conditions relatively cooler greenhouse air to relatively warmer greenhouse air and, in relatively hot weather geographical locations, the earth tube heat exchanger conditions relatively warmer greenhouse air to relatively cooler greenhouse air,and wherein the earth tube heat exchanger maintains the greenhouse air temperature at a predetermined temperature set point which is equal to an average thermal constant temperature of the geographical location of the greenhouse; anda carbon dioxide sensor,wherein when the content of carbon dioxide in the greenhouse is higher than a predetermined carbon dioxide content set point due to carbon dioxide released by the plants during the dark hours or due to residual carbon dioxide available after carbon dioxide enrichment events during the sunlight hours, the greenhouse carbon dioxide sensor switches on the capture manifold, the compressor, the first tank (T1), the second tank (T2), the release manifold, the third tank (Ta), and the earth tube heat exchanger, and the capture manifold captures the carbon dioxide rich greenhouse air, the compressor compresses the captured carbon dioxide rich greenhouse air, the compressed carbon dioxide rich greenhouse air is dehumidified in the first and second tanks (T1) and (T2), the carbon dioxide rich dehumidified greenhouse air is stored into the first compartment (Ec) and the release manifold releases into the greenhouse, at a cultivation level, the oxygen rich dehumidified conditioned greenhouse air stored in the second compartment (Eo) for maintaining the greenhouse carbon dioxide content at the predetermined carbon dioxide content set point which is equal to the content of carbon dioxide in the atmosphere, and wherein the greenhouse reduces global warming by preventing the greenhouse carbon dioxide from being released into the atmosphere by capturing, compressing, dehumidifying, storing and utilizing the greenhouse carbon dioxide for enrichment during the sunlight hours for maximizing the yield of plants growing in the greenhouse and for maintaining the greenhouse carbon dioxide content at the predetermined carbon dioxide content set point that is equal to the atmospheric carbon dioxide content.

US Pat. No. 10,477,776

SPRING-LOADED WREATH HANGER

1. An over-the-door apparatus attachable to a door structure, comprising:a base plate having a first receptacle and a second receptacle spaced from each other, said base plate engageable with an outside surface of the door structure;
a first elongate wing having a pivot post attached to an inner end of said wing, the pivot post of said wing insertable into said first receptacle, said first wing having a downturned end located at an outer end of said first wing, the downturned end engaging an inside surface of the door structure;
a second elongate wing having a pivot post attached to an inner end of said second wing, the pivot post of said second wing insertable into said second receptacle, said second wing having a downturned end located at an outer end of said second wing, the downturned end of said second wing also engaging the inside surface of the door structure; and
a single spring member having spaced apart torsion springs connected with a connecting wire, said spring member for biasing said first and second elongate wings with respect to said base plate, and wherein the downturned ends of said first and second elongate wings are biased against the inside surface of the door structure.

US Pat. No. 10,477,771

AGRICULTURAL HARVESTER HAVING A HEADER BASED HEAT EXCHANGER

CNH Industrial America LL...

1. An agricultural harvester header for operative attachment to a combine, the header comprising:an agricultural harvester header hydraulic system having a header hydraulic fluid, and
a heat exchanger operatively connected to the agricultural harvester header hydraulic system and configured to transfer heat between the header hydraulic fluid and another hydraulic fluid.

US Pat. No. 10,477,760

AGRICULTURAL ORGANIC DEVICE FOR WEED CONTROL

Underground Agriculture, ...

1. An agricultural system comprising:a frame linkage for attachment to an agricultural vehicle; and
at least one cutting device for cutting planted matter in a planted field, the cutting device being mounted to the frame linkage and positioned between respective adjacent rows of the planted matter in the field and including
a vertically-adjustable shaft having an upper end and a lower end, the upper end being the only portion of the at least one cutting device mounted directly to the frame linkage, and
a cutting unit attached to the lower end of the shaft, the cutting a rotatable blade for cutting the planted matter, including weeds, growing between the adjacent rows of the planted matter, the cutting unit being attached concentrically with a vertical axis of the shaft; and
at least one dedicated electric motor mounted to the upper end of the shaft for driving the rotatable blade of the cutting unit, the electric motor being external to the cutting unit.

US Pat. No. 10,477,759

GRASS MOWER

Kubota Corporation, Osak...

1. A grass mower comprising:a drive wheel unit;
a variable speed drive mechanism for driving the drive wheel unit;
a mower unit having a cutter blade;
a cutter blade drive mechanism for rotatably driving the mower unit;
a man-operable vehicle speed controlling tool which is operated in a range from a zero vehicle speed position to a maximal vehicle speed position;
an operation detection section for detecting an operational position of the man-operable vehicle speed controlling tool;
a vehicle speed instruction value calculation section for generating a vehicle speed instruction value including a maximal vehicle speed, based on the operational position of the man-operable vehicle speed controlling tool detected by the operation detection section;
a mode selection section for selecting a control mode from a plurality of control modes;
a control table in which a plurality of control parameters are set, the control parameters being provided for the respective control modes, each of the control parameters including a rotational speed value of the cutter blade and a maximal vehicle speed value corresponding to the rotational speed value;
a vehicle speed control target value calculation section configured to calculate a vehicle speed control target value, based on a vehicle speed instruction value generated by the vehicle speed instruction value calculation section and a selected control parameter corresponding to the control mode selected by the mode selection section;
a traveling control section configured to control the variable speed drive mechanism based on the vehicle speed control target value;
a cutter blade control target value calculation section configured to calculate a rotational speed control target value for the cutter blade, based on the selected control parameter; and
a cutter blade control section configured to control the cutter blade drive mechanism based on the rotational speed control target value.

US Pat. No. 10,477,758

MULTIPLE SEED-TYPE SEED METER

CNH Industrial America LL...

1. A planter for planting multiple types of seed in a single planting pass during row-crop planting of an agricultural field, comprising:a frame;
a bulk storage system supported by the frame and configured for storing multiple types of seeds;
multiple row units supported by the frame, each of the multiple row units including,
an on-row storage system with multiple compartments configured to receive respective ones of the multiple types of seed from the bulk storage system; and
a seed meter for planting the multiple types of seed and including a housing having multiple portions defining multiple seed chambers respectively receiving seeds of multiple types from the multiple compartments of the on-row storage system and multiple seed disk assemblies for selectively delivering individual seeds of the multiple seed types from the multiple seed chambers of the seed meter out of the housing for release onto an agricultural field during row-crop planting of the agricultural field.

US Pat. No. 10,477,755

IMPLEMENT WITH FOLDABLE TOOLBAR SYSTEM

UNVERFERTH MANUFACTURING ...

1. A method of operating an agricultural implement comprising a frame having a longitudinal axis and laterally opposed sides, a first wing carried by the frame, and at least one second wing, each second wing is pivotably connected to the first wing, the method comprising:(a) raising, by an elevator mechanism, the first wing and the second wing in a vertical direction from a lowered operating position to a raised operating position; and
(b) pivoting, by a wing pivot assembly comprising a skewed hinge, the second wing with respect to the first wing about a first pivot axis defined by the skewed hinge from the raised operating position to a transport position in one continuous motion;
wherein at the raised operating position, the second wing extends from the frame in a lateral direction with respect to the longitudinal axis, and at the transport position, the second wing extends alongside one of the opposed sides of the frame;
wherein the first pivot axis is oriented at an acute angle with respect to the longitudinal axis.
US Pat. No. 10,477,803

PLANTS AND SEEDS OF CORN VARIETY CV691303

Monsanto Technology LLC, ...

1. A plant of corn variety CV691303, wherein representative seeds of corn variety CV691303 have been deposited under ATCC Accession No. PTA-125239.
US Pat. No. 10,477,805

INBRED CORN LINE 7DBDD0188

Agrigenetics, Inc., Indi...

1. Seed of corn inbred line designated 7DBDD0188, or a part thereof, representative seed of the line having been deposited under ATCC Accession No. PTA-124386.
US Pat. No. 10,479,858

EPOXY RESIN SYSTEM FOR MAKING CARBON FIBER COMPOSITES

Dow Global Technologies L...

1. A curable epoxy resin system, comprising1) an epoxy resin component containing one or more epoxy resins, wherein at least 80% by weight of the epoxy resins is one or more polyglycidyl ethers of a polyphenol that has an epoxy equivalent weight of up to about 250;
2) an amine hardener, wherein the amine hardener is a polyethylene tetraamine mixture containing at least 95% by weight polyethylene tetraamines, the mixture containing at least 40% by weight linear triethylene tetraamine, wherein the epoxy resin component provides at least 0.8 epoxy equivalents per amine hydrogen equivalent provided by the amine hardener; and
3) 0.01 to 0.5 moles of triethylene diamine per mole of primary and/or secondary amine compounds in the amine hardener, the triethylene diamine being present in the epoxy resin component, the amine hardener, or both;
wherein the resin system further comprises an internal mold release agent mixed with a dye solution, wherein the dye is a naphthalene diazine functionality with low degree of sulfonation.
US Pat. No. 10,477,811

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH699413

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH699413, produced by crossing a first plant of variety CV292720 with a second plant of variety CV132428, wherein representative seeds of said varieties CV292720 and CV132428 are deposited under ATCC Accession Nos. PTA-9834 and PTA-121108, respectively.
US Pat. No. 10,481,147

CARDIAC STEM CELLS AND METHODS OF IDENTIFYING AND USING THE SAME

VESTION, INC., Miami, FL...

1. A method of treating a heart disease in a subject in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of isolated composition of cardiac progenitor cells, wherein the composition of cardiac progenitor cells comprises cardiac progenitor cells that are phosphorylated retinoblastoma protein positive.
US Pat. No. 10,477,812

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH350667

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH350667, produced by crossing a first plant of variety CV742016 with a second plant of variety CV751695, wherein representative seeds of said varieties CV742016 and CV751695 are deposited under ATCC Accession Nos. PTA-124493 and PTA-124503, respectively.
US Pat. No. 10,479,865

PROCESS FOR THE PREPARATION OF SEVELAMER CARBONATE

Strides Shasun Limited, ...

1. A process for the preparation of Sevelamer carbonate, comprising:(a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH of more than 12;
(b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
(c) optionally washing the gel with at least one of water miscible solvent(s) and water;
(d) suspending the obtained gel in step (b) or step (c) in water;
(e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate; and
(f) optionally washing the Sevelamer carbonate with at least one of water miscible solvent(s) and water.
US Pat. No. 10,480,123

SUPERCRITICAL FLUID MATERIAL FINISHING

NIKE, Inc., Beaverton, O...

1. A method of finishing a target material in a pressure vessel while reducing deposition of a finishing material in the pressure vessel, the method comprising;positioning a target material in a pressure vessel;
introducing carbon dioxide (“CO2”) within the pressure vessel;
increasing an internal temperature of the pressure vessel to an operating temperature;
increasing a pressure within the pressure vessel to an operating pressure, wherein the CO2 is at supercritical fluid (“SCF”) state when at the operating temperature and the operating pressure;
perfusing, using SCF CO2, the target material with a finishing material;
increasing a flow rate to a nonzero rate during the perfusing of the target material with the finishing material, wherein the flow rate in a range of 175-240 m3/hr;
reducing the pressure from the operating pressure to a transition pressure prior to reducing the operating temperature to a threshold temperature; and
reducing the flow rate to a flow rate in a range of 90-130 m3/hr after reducing the pressure from the operating pressure.
US Pat. No. 10,481,149

METHOD FOR MEASURING BILE SALT EXPORT TRANSPORT AND/OR FORMATION ACTIVITY

Biotranex, LLC, Monmouth...

1. A method for assessing a test agent's effect on bile salt export transport and/or formation activity comprising:(a) separately incubating a hepatocyte suspension preparation and a bile salt precursor with and without a test agent at about 37° C. under conditions allowing bile salt export transport and/or formation for a time sufficient to assess bile salt export transport and/or formation activity of bile salt precursor derived bile salts,
(b) post-incubation separating extracellular media and intracellular media of the hepatocyte suspension preparations; and
(c) quantifying the bile salt precursor derived bile salts present in the extracellular and/or intracellular media of the post-incubation hepatocyte suspension preparations.
US Pat. No. 10,479,868

POLYMERIC STABILIZING FORMULATIONS

NANO PRECISION MEDICAL, I...

1. A pharmaceutical composition comprising:a therapeutic agent, which therapeutic agent is a peptide, together with a polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups, wherein the polymer is a dendritic polymer or is a crossed-linked polymer, wherein said pharmaceutical composition is disposed within a reservoir of a capsule having a nanoporous membrane with a plurality of pores, the capsule configured for implantation; and
the polymeric stabilizing agent comprising a polymer having a plurality of stabilizing groups having molecular dimensions larger than the pore size of the nanoporous membrane, wherein the release of the polymeric stabilizing agent from the reservoir is substantially prevented; and wherein the nanoporous membrane is a diffusion pathway out of the reservoir for the therapeutic agent.
US Pat. No. 10,477,816

SOYBEAN VARIETY 5PZWF45

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PZWF45, representative seed of the variety having been deposited under ATCC Accession Number PTA-126070.
US Pat. No. 10,479,872

ANTIFOGGING FILM

FUJIFILM Corporation, To...

1. An antifogging film comprising:a film base which is formed of cellulose acylate; and
a saponified layer which is provided on one base surface of the film base, serves as one film surface, and contains saponified cellulose acylate,
wherein a contact angle 15 seconds after dropping of pure water to the one film surface is 20° or less, and
in a case where an amount of acyl groups of the one film surface is X and an amount of acyl groups of the other base surface of the film base is Y, an acyl group ratio obtained by X/Y is 0.7 or less.
US Pat. No. 10,479,873

METHOD OF PRODUCING POLYMER-IMPREGNATED BASE RESIN

SUMITOMO RUBBER INDUSTRIE...

1. A method of producing a polymer-impregnated base resin, the method comprising impregnating a base resin with a polymer solution that comprises a solvent able to swell the base resin,wherein the polymer is at least one selected from the group consisting of a homopolymer or copolymer of one or two or more hydrophilic monomers, and a copolymer of one or two or more hydrophilic monomers with an additional monomer(s), and
wherein at least one of the hydrophilic monomer is an alkoxyalkyl (meth)acrylate.
US Pat. No. 10,477,822

SOYBEAN VARIETY 01069686

Monsanto Technology LLC, ...

1. A plant of soybean variety 01069686, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125858.
US Pat. No. 10,477,823

SOYBEAN VARIETY 01069720

Monsanto Technology LLC, ...

1. A plant of soybean variety 01069720, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125861.
US Pat. No. 10,479,878

ANTI-VIBRATION RUBBER COMPOSITION

SUMITOMO RIKO COMPANY LIM...

1. An anti-vibration rubber composition, comprising:(A) a diene-based rubber;
(B) a halogen-based flame retardant having a melting point of 150° C. or less; and
(C) aluminum hydroxide having an average particle diameter of 0.4 ?m or less,
wherein a blending amount of the halogen-based flame retardant (B) falls within a range of from 15 parts by weight to 60 parts by weight with respect to 100 parts by weight of the diene-based rubber (A), and a blending amount of the aluminum hydroxide (C) falls within a range of from 50 parts by weight to 150 parts by weight with respect to 100 parts by weight of the diene-based rubber (A).
US Pat. No. 10,481,165

ELEVATED CCL19 AFTER COMPLETION OF THERAPY FOR ACUTE LYME DISEASE IDENTIFIES PATIENTS AT RISK FOR DEVELOPMENT OF POST-TREATMENT LYME DISEASE SYNDROME WHO WILL BENEFIT FROM FURTHER ANTIBIOTIC THERAPY

The Johns Hopkins Univers...

1. A method for treating a patient likely to develop post-treatment Lyme disease syndrome (PTLDS) and who is currently undergoing a first course of antibiotic treatment for Lyme disease comprising the step of prescribing or administering a second course of antibiotic treatment to a patient who is determined to have an increased level of CCL19 as compared to a control after completing a first course of antibiotics for Lyme disease.
US Pat. No. 10,479,883

COMPOSITIONS FOR AUTOMOTIVE INTERIOR PARTS

SABIC GLOBAL TECHNOLOGIES...

1. Composition comprising a heterophasic propylene copolymer and an ethylene polymer wherein the ethylene polymer has a density as measured according to ISO 1183-1 (2012), method A of ?940 kg/m3, the ethylene polymer has a multimodal molecular weight distribution and the ethylene polymer has a strain hardening modulus of ?5.0 MPa, the strain hardening modulus being measured according to ISO DIS 18488 (2014) using test specimens of 0.30 mm thickness.
US Pat. No. 10,479,884

AQUEOUS COMPOSITION FOR HARD SURFACE APPLICATIONS WITH ENHANCED STABILITY

CHEMETALL U.S., INC., Ne...

1. An aqueous composition for hard surface applications comprising at least one lipophilic compound that is an oil and at least one copolymer, characterized in that the at least one copolymer is a comb-type branched copolymer exhibiting an alternating sequence of monomeric units (a) each having at least one hydrophilic group and monomeric units (b) each having at least one lipophilic side chain,wherein the at least one copolymer exhibits a molecular weight distribution the range of 1.2 to 3.0.
US Pat. No. 10,479,890

OXYGEN SCAVENGING POLYESTER COMPOSITIONS FOR CONTAINERS

APG Polytech, LLC, Wilmi...

1. An oxygen scavenging composition for containers comprising:at least one polyester component,
a transition metal catalyst,
an oxygen scavenger, and
a vegetable oil comprising at least one molecule having a double allylic structure,wherein the at least one polyester component comprises at least one acid unit and at least one diol unit, the concentration of the double allylic structures of the vegetable oil in the composition is greater than 5.0 meq/kg of all of the polyester components, the oxygen scavenger is present in the composition in a traditionally inert amount, and the vegetable oil is present in the composition at a level greater than 0.3% by weight relative to the total weight of the polyester components, the transition metal catalyst and the vegetable oil.
US Pat. No. 10,479,895

LIQUID REPELLENT SURFACES

United States of America ...

1. A method of making a liquid repellent coating on a non-porous surface, the method comprising:combining a fluoropolymer with a polymer, the polymer being poly(ethyl methacrylate), poly(butyl methacrylate), or both, to form a mixture; and
applying the mixture to the non-porous surface to form a coating thereon, the coating being hydrophobic and oleophobic.
US Pat. No. 10,479,898

COATING COMPOSITION FOR SUBSTRATES IMMERSED IN WATER

AKZO NOBEL COATINGS INTER...

1. A coating composition comprisinga) seawater-hydrolyzable groups covalently linked to an acrylic polymer, which seawater-hydrolyzable groups are capable of undergoing hydrolysis or ion-exchange when exposed to seawater, rendering the polymer partially soluble or dispersible in seawater, and
b) zwitterionic groups covalently linked to the acrylic polymer
wherein the molar ratio of the seawater-hydrolyzable groups a) to the zwitterionic groups b) is 0.1 or higher,
wherein the seawater hydrolyzable groups are selected from
the group consisting of non-metal salt groups, metal salt groups, silyl ester groups, and mixtures thereof, and
wherein the non-metal salt groups covalently linked to the acrylic polymer are
selected from the group consisting of quaternary and acid salts of dialkylaminoalkyl(meth)acrylates, quaternary and acid salts of dialkylaminoalkyl(meth)acrylamides, N,N-diallyldialkyl ammonium halide, (3-methacryloylamido)propyl trimethylammonium halide salt; (3-acryloylamido)propyl trimethylammonium halide salt; (3-methacryloylamido)propyl trimethylammonium sulfonate salt, (3-acryloylamido)propyl trimethylammonium sulfonate salt, (3-methacryloyl)propyl trimethylammonium sulfonate salt, (3-acryloyl)propyl trimethylammonium sulfonate salt, and
amine and phosphine salts of polymerizable unsaturated carboxylic and sulphonic acids
wherein the silyl ester groups covalently linked to the acrylic polymer are selected from the group consisting of triisopropylsilyl (meth)acrylate, triisobutylsilyl (meth)acrylate, triphenylsilyl (meth)acrylate, and t-butyldiphenylsilyl (meth)acrylate.
US Pat. No. 10,479,903

UV-CURABLE INKJET INK COMPOSITION

SHOWA ALUMINUM CAN CORPOR...

1. A UV-curable inkjet ink composition that contains a monofunctional monomer (A), a polyfunctional monomer (B), a photopolymerization initiator (C) and a colorant (D) and is cured by irradiation with ultraviolet light, whereina hydroxyl value of the UV-curable inkjet ink composition is in a range of not less than 1 mgKOH/g and not more than 100 mgKOH/g, and
the UV-curable inkjet ink composition forms, by inkjet printing, an ink layer provided between a curved outer peripheral surface of a can base made of a cylindrical metallic material and a covering layer made of an aqueous coating material.
US Pat. No. 10,479,907

VINYL ACETATE BINDERS IN AN ABOVE-CRITICAL PVC COATINGS COMPOSITION

Dow Global Technologies L...

1. A coating composition comprising an aqueous dispersion of polymer particles, pigment particles, and extender particles wherein the polymer particles comprise, in a single phase and based on the weight of the polymer particles, greater than 80 up to 99.8 weight percent structural units of vinyl acetate; from 0.1 to 6 weight percent structural units of a phosphorus-containing acid monomer or a salt thereof; and from 0.1 to 2 weight percent structural units of a sulfur-containing acid monomer or a salt thereof; wherein the polymer particles have a particle size by dynamic light scattering of from greater than 350 nm to 500 nm, and wherein the coating composition has an above-critical pigment volume concentration, as determined by reflectance, wherein the phosphorus-containing acid monomer or salt thereof is a dihydrogen phosphate esters of an alcohol in which the alcohol contains or is substituted with a polymerizable vinyl or olefinic group.
US Pat. No. 10,479,908

METHOD OF MANUFACTURING HARD COAT FILM

FUJIFILM Corporation, To...

1. A composition, which is a photopolymerizable hard coating composition comprising:a radical polymerizable compound having two or more radical polymerizable groups selected from the group consisting of acryloyloxy groups, acryloyl groups, methacryloyloxy groups, and methacryloyl groups per molecule;
a cationic polymerizable compound;
a radical photopolymerization initiator; and
a cationic photopolymerization initiator,
wherein the cationic polymerizable compound comprises a cyclic structure-containing compound,
wherein the cyclic structure-containing compound contains a nitrogen-containing hetero ring-containing compound, and
wherein the nitrogen-containing hetero ring-containing compound contains one or more nitrogen-containing hetero ring selected from the group consisting of isocyanurate rings and glycoluril rings per molecule.
US Pat. No. 10,479,909

BIRD-REPELLENT COATING MATERIAL

WINTON OSAKA CO., LTD., ...

1. A bird-repellent coating material comprising:a microencapsulated aqueous dispersion of a visual repellent against birds; and
an aqueous resin vehicle,
wherein the microencapsulated aqueous dispersion of the visual repellent against birds is incorporated into the aqueous resin vehicle.
US Pat. No. 10,477,859

PLANT EMBRYO STORAGE AND MANIPULATION

PIONEER HI-BRED INTERNATI...

1. A method for performing molecular analysis of one or more plant embryos comprising agitating the plant embryos to remove cellular material for molecular analysis, storing the one or more plant embryos in an aqueous solution surrounded by a matrix of at least two oils, wherein one of the at least two oils is more dense than the aqueous solution and one of the at least two oils is less dense than the aqueous solution, obtaining genetic material from the cellular material removed from the plant embryos, and performing molecular analysis of the genetic material.
US Pat. No. 10,479,913

SILICONE COMPOSITION AND A PRESSURE SENSITIVE ADHESIVE FILM HAVING A PRESSURE SENSITIVE ADHESIVE LAYER MADE FROM THE COMPOSITION

Dow Silicones Corporation...

1. A silicone composition comprising:(A) a diorganopolysiloxane having at least two alkenyl groups in a molecule and having a viscosity at 25° C. of from 10,000 to 1,000,000 mPa·s, in an amount of from 60 to 80 mass % based on the mass of the composition;
(B) a diorganopolysiloxane having at least one alkenyl group in a molecule, and being raw and rubber-like at 25° C. or having a viscosity at 25° C. of more than 1,000,000 mPa·s, in an amount of from greater than 0 to 10 mass % based on the mass of the composition;
(C) an organopolysiloxane resin represented by the following average unit formula:
(R13SiO1/2)x(SiO4/2)1.0
wherein each R1 represents a halogen-substituted or un-substituted monovalent hydrocarbon group free from an alkenyl group and x is a number from 0.5 to 1.0, in an amount of from 0.5 to 20 mass % based on the mass of the composition;
(D) an organohydrogenpolysiloxane having at least two silicon-bonded hydrogen atoms in a molecule, in a quantity that provides from 0.1 to 10 moles of the silicon-bonded hydrogen atoms in this component per 1 mole of the total alkenyl groups in the composition;
(E) silica fine powder in an amount of from 0.5 to 5 mass % based on the mass of the composition; and
(F) a hydrosilylation catalyst in a quantity that accelerates hydrosilylation of the composition.
US Pat. No. 10,477,862

IN SITU GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE PH, AND METHODS OF USE THEREOF

Ecolab USA Inc., Saint P...

1. A peroxycarboxylic acid forming composition formed by a method comprising:combining an oxidizing agent with a source of alkalinity;
adding a first reagent comprising an ester of a polyhydric alcohol and a C8 carboxylic acid;
allowing the peroxycarboxylic acid composition to react for a sufficient amount of time such as a C8 peroxycarboxylic acid is formed; and thereafter
adding a second reagent comprising an ester of a polyhydric alcohol and a C2 carboxylic acid; and
optionally further adding one or more agents, wherein the one or more agents are a dispersing agent, and/or a solvent;
wherein the first and second reagents have an HLB value of 3 or greater; and
wherein the composition is not at equilibrium and has a pH greater than 12.
US Pat. No. 10,482,994

METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS

Sequenom, Inc., San Dieg...

1. A computer-implemented method for determining fetal fraction based on a copy number variation in a maternal genome, comprising:(a) sequencing a test sample from a pregnant female bearing a fetus by a non-targeted massively parallel sequencing process that generates nucleotide sequence reads, the test sample comprising circulating cell-free nucleic acid from (i) a maternal genome and (ii) a fetal genome; mapping the sequence reads to genomic sections of a reference genome; and counting the sequence reads mapped to the genomic sections of the reference genome, thereby obtaining counts of sequence reads mapped to the genomic sections of the reference genome;
(b) normalizing, using a microprocessor, the counts mapped to the genomic sections of the reference genome, thereby providing normalized counts for the genomic sections;
(c) identifying a first elevation of the normalized counts for a first set of genomic sections significantly different than a second elevation of the normalized counts for a second set of genomic sections, wherein the first set of genomic sections and the second set of genomic sections are within the same chromosome;
(d) determining a copy number variation in the maternal genome for the first set of genomic sections based on the identified first and second elevations;
(e) determining a categorization for the copy number variation in the maternal genome by comparing the first elevation to expected elevations for predetermined copy number variation categorizations; and
(f) determining, using a microprocessor, a fetal fraction of the circulating cell-free nucleic acid according to the first elevation and a deviation from an expected elevation of normalized counts for the categorization.
US Pat. No. 10,482,997

METHOD FOR DETERMINING THREE-DIMENSIONAL STRUCTURES OF DYNAMIC MOLECULES

Conformetrix Limited, Ma...

1. A method for generating an ensemble of discrete molecular structures representing a range of three-dimensional shapes of a solvated molecule, the molecule comprising a plurality of bonds each having an associated mean dihedral angle, wherein at least one bond is a rotatable bond having an associated distribution of dihedral angles, the method comprising:receiving a set of internal coordinates of the molecule, said internal coordinates comprising a predefined mean dihedral angle for each bond; then
assigning a probability distribution function to each bond, the probability distribution function comprising a predefined variability of the dihedral angle for said bond with respect to said predefined mean dihedral angle, the probability distribution function independent of experimental data for the solvated molecule; and then
generating an ensemble of structures by implementing the set of internal coordinates and the assigned probability distribution functions by varying said dihedral angle for each bond according to said predefined dihedral angle variability; and then
analyzing the ensemble of structures as a group,
wherein all of the preceding steps are performed on a computer, and
wherein the predefined variability of the dihedral angle for a rotatable bond is non-zero and corresponds to the associated distribution of dihedral angles.
US Pat. No. 10,477,869

NACL SUBSTITUTE AGENT

LESAFFRE ET COMPAGNIE, P...

1. A method for reducing the amount of NaCl in breadmaking, comprising a step of totally or partially replacing NaCl with a NaCl substitute, said NaCl substitute consisting of deactivated yeast and NaCl, and optionally a cereal extract and/or a breadmaking improver selected from the group consisting of ascorbic acid, emulsifiers, stabilizing-thickening agents, enzymes and mixtures thereof, wherein the NaCl/deactivated yeast ratio is between 1 and 5.7.
US Pat. No. 10,478,384

DENTAL COMPOSITION

Zimmer Dental, Inc., Car...

1. A dental composition for a dental implant insertable into an implant site, comprising:a reaction product of a reaction mixture comprising:
a first mixture comprising:
a ceramic based biomaterial including hydroxyapatite,
a diluent comprising a cross-linking agent, and
a first initiator, and
a second mixture comprising:
mineral trioxide aggregate reacts with moisture at the implant site to form a solid scaffold on the dental implant,
a phosphoric acid monomer reacts with the ceramic based biomaterial and the mineral trioxide aggregate to bond the ceramic based biomaterial to the solid scaffold of mineral trioxide aggregate, and
a second initiator;
wherein the diluent reacts with the phosphoric acid monomer to crosslink at least the phosphoric acid monomer.
US Pat. No. 10,479,924

PACKING FLUIDS AND METHODS

HALLIBURTON ENERGY SERVIC...

1. A packing fluid comprising:(a) an aqueous solvent;
(b) ammonium tungstate dissolved in the solvent; and
(c) one or more solid weighting agents,
the ammonium tungstate is in an amount such that the density of the packing fluid is from about 15 lbs/gal to about 22 lbs/gal.
US Pat. No. 10,478,132

GLUCOSE CONJUGATED GOLD NANOPARTICLE

BAR-ILAN UNIVERSITY, Ram...

1. A composition comprising:a gold nanoparticle;
PEG or derivatives thereof, wherein said PEG and derivatives thereof have a molecular weight of 400 to 1000 Dalton; and
a 2-Deoxy-D-glucose,
wherein said PEG or derivatives thereof are linked to said gold nanoparticle and to said 2-Deoxy-D-Glucose, wherein said PEG or derivatives thereof are linked to said gold nanoparticle via a chemical attachment selected from the group consisting of: covalent attachment, semi-covalent attachment and non-covalent attachment,
wherein said 2-Deoxy-D-Glucose is linked to said PEG and derivatives thereof at the 2-Carbon position of said 2-Deoxy-D-Glucose; and
wherein said composition has a diameter of 20 to 60 nanometers.
US Pat. No. 10,477,876

DRINK COMPOSITION PREPARED FROM COFFEE BEAN OF TREE CULTIVATED WITH RED GINSENG POWDERED EXTRACT

TROY CO., LTD., (KR)

1. A drink composition containing as an active ingredient, a coffee bean powdered extract containing ginsenoside removed of more than one hydroxyl group which is manufactured by cultivating a coffee tree by using a red ginseng powdered extract, comprising: resting a coffee seed by dipping the coffee seed in an aqueous solution of the red ginseng powdered extract for a predetermined period of time to produce a rested coffee seed; wherein the aqueous solution of the red ginseng powdered extract includes ginsenoside as the active ingredient, and wherein the ginsenoside has more than one hydroxyl group removed by passing the aqueous solution of red ginseng powdered extract through a semipermeable membrane wherein a hydrogen ion has been introduced to the semipermeable membrane from outside through a hydrogen ion supply route.
US Pat. No. 10,478,391

SKIN-CARE FORMULATION FOR TREATING ANTI-AGING AND WRINKLE REDUCTION

1. A formulation comprising:apitoxin;
a combination of Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate equivalent biomimetic peptide;
?conotoxin CnCIII;
a combination of Glycerin, Aqua, Terminalia Ferdinandiana Fruit Extract;
at least one chelating agent;
wherein the at least one chelating agent is Tetrasodium Glutamate Diacetate that has a percentage range of 0.01-1.00% within the formulation;
deionized water that has a percentage range of 5-80% within the formulation;
at least one type of emollient that has a percentage range of 0.50-7.00% within the formulation;
wherein the at least one type of emollient is selected from a list consisting of Caprylic/Capric Triglyceride, Isononyl Isononanoate, Squalane and Pataua Oil;
at least one type of emulsifier that has a percentage range of 1.00-10.00% within the formulation;
wherein the at least one type of emulsifier is Hydrogenated Lecithin, C12-16 Alcohols, Palmitic Acid or Cetyl Alcohol, Glyceryl Stearate, PEG-75 Stearate, Ceteth-20 , Steareth-2 or both:
at least one a type of humectant, at least one a type of neutralizer, at least one a type of non-ionic surfactant/emulsifier and at least one a type of preservative; and
at least one a type of rheology modifier and at least one a type of sensorial modifier or mattifying agent.
US Pat. No. 10,478,392

PEPTIDE AND COSMETIC COMPOSITION COMPRISING SAME FOR PREVENTING SKIN AGING OR SKIN WRINKLE FORMATION

College of Medicine Pocho...

1. A peptide having an activity of facilitating bindings between keratinocytes and increasing expression of junction proteins, consisting of the sequence of SEQ ID NO: 2.
US Pat. No. 10,478,394

COMPOSITIONS AND METHODS TO PROMOTE WOUND HEALING

Wayne State University, ...

1. A method of promoting healing of a chronic wound in a diabetic subject comprising administering to the chronic wound a therapeutically effective amount of a gel comprising a therapeutic agent consisting of a therapeutic protein consisting of the sequence provided in SEQ ID NO: 26 (anakinra), thereby promoting healing of the chronic wound.
US Pat. No. 10,479,934

STABILIZED SCINTILLATOR

1. A stabilized scintillator, comprising:a compound corresponding to formula (3), or activated derivatives thereof:
A2BB?XxX?y  (3)wherein A and B are monovalent cations, B? is a trivalent cation, X is a halogen, x and y are molar percentages, wherein x+y=6; X? is an aliovalent exchange anion that has a different valence than X;wherein a crystal of the stabilized scintillator is clear throughout;
wherein the stabilized scintillator has improved photoluminescence quantum yield over a base compound of structure (1)
A2sBB?X6  (1)
wherein A, B, B? and X are the same as above.
US Pat. No. 10,478,397

AVIAN TINCTURE

1. A method for producing a tincture formula comprising:(i) creating a plurality of tinctures, each of the plurality of tinctures produced by:
a) mixing a ratio of at least one herb with a liquid including 190 proof neutral organic grain alcohol diluted with water into a first container, wherein the herb is a fresh herb or a dried herb;
b) sealing the first container to provide an air tight environment;
c) shaking the mixture 2-3 times a day for 2 weeks;
d) straining the herb material to separate it from the liquid mixture;
e) pouring the liquid mixture into a second container; and
f) sealing the second container containing the liquid mixture and storing it; and
(ii) combining the plurality of tinctures to produce the tincture formula,
wherein the plurality of tinctures includes: a tincture of Achillea millifolium(Yarrow) mixed with a liquid of 50% alcohol and 50% water, a tincture of Hypericum perforatum (St. John's Wort) mixed with a liquid of 50% alcohol and 50% water, a tincture of Anemopsis californicum (Yerba Mansa) mixed with a liquid including 60% alcohol and 40% water, a tincture of Rumex crispus (Yellow Dock) mixed with a liquid of 50% alcohol and 50% water, and a tincture of capsicum (Cayenne) mixed with a liquid including 95% alcohol and 5% water;
wherein the tincture formula composition contains 4 parts Yarrow, 4 parts St. John's Wort, 2 parts Yerba Mansa, 1 part Yellow Dock, and 1 part Cayenne;
wherein the tincture formula is configured to treat bumblefoot in avian species and dissolves abscesses free of invasive lancing or cutting open of infected areas; and
wherein the tincture formula further relieves inflamed and swollen leg joints in the avian species.
US Pat. No. 10,478,399

MODIFIED RELEASE TABLET COMPOSITION COMPRISING MIRABEGRON

Synthon B.V., Nijmegen (...

1. A modified release tablet composition comprising:a) 5 to 25 wt % with respect to the total weight of the uncoated tablet of a therapeutically effective dose of mirabegron or a pharmaceutically acceptable salt thereof; and
b) polyethylene oxide (PEO) having an average molecular weight of approximately 7,000,000 or a viscosity of 7500 to 10000 cps at a 1% aqueous solution at 25° C. and polyethylene glycol (PEG) having an average molecular weight of approximately 6000 to 10000, wherein the weight ratio PEO to PEG ranges from 1:3 to 1:4.5;
wherein said tablet exhibits an in vitro dissolution profile that meets the following release criteria: 15%-35% of mirabegron is released within 1 hour, at least 50% of mirabegron is released within 2 hours, and at least 90% of mirabegron is released within 3 hours, wherein said dissolution profile is measured in 250 ml phosphate buffer (pH 6.8) using USP apparatus 3 at 20 dpm and 37° C.
US Pat. No. 10,479,681

FLUORINATING AGENT

DAIKIN INDUSTRIES, LTD., ...

1. A method for fluorinating a compound, the method comprising:bringing the compound into contact with a complex consisting of bromine trifluoride and at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals.
US Pat. No. 10,477,885

TOMATO-DERIVED THICKENING AGENT

Conopco Inc., Englewood ...

1. A process for preparing a tomato-derived thickening agent comprising the steps of:a. providing a tomato pulp containing 3-15 wt. % tomato soluble solids (TSS) and 0.3-5 wt. % tomato insoluble solids (TIS);
b. isolating from said tomato pulp a tomato serum fraction having a reduced TIS content of less than 2.0 wt. % and a TSS content of at least 3 wt. %;
c. subjecting said tomato serum fraction to a filtration step to produce a retentate and a filtrate, said filtration step employing a membrane with a molecular weight cut-off (MWCO) in the range of 10-20,000 kDa;
d. collecting the retentate; and
e. drying the retentate to obtain the tomato-derived thickening agent.
US Pat. No. 10,478,402

SOLID NANOPARTICLE WITH INORGANIC COATING

Nanexa AB, Uppsala (SE)

1. A method of preparing a controlled or delayed release pharmaceutical composition comprising:i. a plurality of coated particles of a size that is from 0.1 ?m to 50 ?m, said coated particles having a solid core comprising a biologically active substance, said solid core being enclosed by one or more metal oxide materials; and
ii. a pharmaceutically acceptable carrier,
the method comprising the sequential steps of:
(1) applying an initial coating of at least one metal oxide to said solid cores in an atomic layer deposition reactor;
(2) discharging the coated particles from the reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1);
(3) reintroducing the disaggregated, coated particles from step (2) into an atomic layer deposition reactor and applying a further coating of at least one metal oxide to the reintroduced particles;
(4) optionally repeating steps (2) and (3) one or more times to increase total thickness of the one or more metal oxide materials that enclose said solid core; and
(5) admixing said coated particles obtained from step (3) or step (4) with said pharmaceutically acceptable carrier to form said pharmaceutical composition.
US Pat. No. 10,478,404

MATERIALS, METHODS AND DEVICES FOR ALTERING CELL REACTIVITY

Arizona Board of Regents ...

1. An ex vivo or in vivo method of treating human cells to modulate their reactivity to exogenous physical forces comprising administering to human cells subjected to exogenous physical forces, a composition comprising an effective amount of one or more agents selected from the group consisting of:(i) a lipid or lipid related compound, hormone, carbachol, atropine, inositol, DMSO, lidocaine, procaine, sex steroids, phenytoin, perylene, 9-(dicyanovinyl) julodinine, 1,6-diphenyl-1,3,5-hexatiene (DPH), TMA-DPH, DPH-PA, cis and trans-parinaric acid, wherein the hormone is selected from the group consisting of cortisol, estradiol, progesterone, medroxyprogesterone, insulin, glucagon, thyroid hormone, and aldosterone;
(ii) sulindac sulfide, phenolic antioxidants, caffeic acid phenethyl ester (CAPE) FAK signaling and modulating agents, resveratrol, Rho kinase inhibitors, Y-27632, inhibitors or modulators of talin, paxilin, and viculin and submembrane mechnotransductive proteins;
(iii) cytochlasins, concanavalin, vincristine, vinblastine, oryzalin, trifluralin, taxol, and taxetere;
(iv) colchicine, colcemid, 9 bromonscapine (EM011), docetaxel, noscapinoids, and tau; or
(v) hypo or hypertonic solutions, saline, lactated ringers, dextrose, sucrose, and mannitol, aqueporin receptors modulating agents, Hg Cl2, G-protein modulating agents, tolvaptan, convivaptan, and vaptans
wherein the exogenous physical force provides a shear stress greater than 50 dynes/cm2, wherein the method further comprising using a ventricular assist device (VAD) to pump blood in a patient's body, wherein the exogenous physical force is a force provided by the VAD.
US Pat. No. 10,479,687

SODIUM THIOSULFATE-CONTAINING PHARMACEUTICAL COMPOSITIONS

Hope Medical Enterprises,...

1. A pharmaceutical composition comprising sodium thiosulfate pentahydrate and one or more pharmaceutically acceptable carriers or excipients, wherein the sodium thiosulfate pentahydrate contains no greater than 8 ppm of non-purgeable organic carbon, contains no greater than 0.05 ppm of mercury, contains no greater than 2 ppm of aluminum, contains no greater than 0.003% by weight of selenium, contains no less than 98% by weight and no greater than about 102% by weight of sodium thiosulfate on an anhydrous basis measured by ion chromatography, has a water content between 32% and 37% by weight, has a heavy metal content of no greater than 10 ppm, contains no greater than 200 ppm of chloride, contains no greater than 0.001% by weight of sulfide, contains no greater than 0.002% by weight of iron, contains no greater than 0.01% by weight of calcium, contains no greater than 0.005% by weight of potassium, contains no greater than 0.1% of sulfite, contains no greater than 0.5% of sulfate, contains no greater than 3 ppm of arsenic, contains no greater than 0.001% by weight of lead, has total aerobic count of microbial load of no greater than 100 CFU/g, has total yeast and mold count of no greater than 20 CFU/g, contains no greater than 0.02 EU/mg of bacterial endotoxins, contains no greater than 0.002% by weight of nitrogen compounds, contains no greater than 0.005% by weight of insoluble matter, contains no greater than 0.01% by weight of residual anti-caking agent, and contains no greater than ICH Q3C (R3) limits of organic volatile impurities, wherein a 10% aqueous solution of the solid sodium thiosulfate pentahydrate at 25° C. is colorless and has a pH between 6.0 and 8.0, and wherein the solid sodium thiosulfate pentahydrate is odorless crystals,wherein the pharmaceutical composition is an enteric-coated capsule or is formulated for rectal administration.
US Pat. No. 10,481,483

LITHOGRAPHY MASK AND METHOD

Taiwan Semiconductor Manu...

1. A photomask comprising:a substrate over a first conductive layer, the substrate formed of a low thermal expansion material (LTEM);
a second conductive layer over the first conductive layer;
a reflective film stack over the substrate;
a capping layer over the reflective film stack;
an absorption layer over the capping layer; and
an antireflection (ARC) layer over the absorption layer, wherein the ARC layer and the absorption layer have a plurality of openings in a first region exposing the capping layer, wherein the ARC layer, the absorption layer, the capping layer, and the reflective film stack have a trench in a second region exposing the second conductive layer.
US Pat. No. 10,481,484

REFLECTIVE MASK BLANK, REFLECTIVE MASK, METHOD FOR MANUFACTURING REFLECTIVE MASK BLANK, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

HOYA CORPORATION, Tokyo ...

1. A reflective mask blank comprising:a substrate, and
a multilayer reflective film, a protective film, and a phase-shift film for shifting a phase of EUV light, which are formed in said order on the substrate,
wherein the protective film is made of a material containing ruthenium as a main component, and
wherein an anti-diffusion layer which contains ruthenium and oxygen is formed on a surface of the protective film, or as a part of the protective film on a side adjacent to the phase-shift film, so as to inhibit counter diffusion in relation to the phase-shift film.
US Pat. No. 10,478,408

COMBINATION TREATMENTS FOR OPIOID CRISIS

1. A method of reducing the chances of alcohol mediated opioid overdose or death during maintenance therapy for management of pain, comprising:selecting a subject for maintenance therapy for management of pain;
administering a single composition to the subject, comprising:
an effective amount of one or more opioid medications for the management of pain; and
an effective amount of one or more aldehyde dehydrogenase inhibitors sufficient to prevent alcohol consumption, the one or more aldehyde dehydrogenase inhibitors selected from disulfiram, calcium carbimide, coprine, cyanamide, 1-aminocyclopropanol, daidzin, cephalosporins, antidiabetic sulfonyl ureas, metronidazole, ampal, benomyl, citral and active isomers thereof, chloral hydrate, chlorpropamide analogs, (benzoyloxy)[4-chlorophenyl)sulfonyl]carbamic acid 1,1-dimethylethyl ester (NPI-1), 4-chloro-N-ethyl-N-[(propylamino)carbonyl]benzenesulfonamid (API-1), 3-(((3-(4-(methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)oxy)methyl)benzoic acid (CVT-10216), N,N-diethylaminobenzaldehyde (DEAB), gossypol, molinate, nitroglycerin, pargyline, or pharmaceutically acceptable salts thereof, enabling provision of the powerful analgesic effects of the opioid in a manner which prevents concomitant alcohol consumption, thereby reducing the risk of alcohol mediated opioid overdose or death during maintenance therapy for management of pain.
US Pat. No. 10,478,410

PROCESS TO PREPARE TREPROSTINIL, THE ACTIVE INGREDIENT IN REMODULIN®

United Therapeutics Corpo...

1. A method of preparing a pharmaceutical batch of a salt of treprostinil that can be stored as a stable compound at ambient temperature, said pharmaceutical batch being at least 2.9 grams, the method comprising (a) alkylating a benzindene triol, (b) hydrolyzing the product of step (a) to form a solution comprising treprostinil, (c) contacting the solution comprising treprostinil from step (b) with a base to form a salt of treprostinil, wherein forming the salt of step (c) reduces the amount of one or more impurities resulting from steps (a) and/or (b) in the pharmaceutical batch.
US Pat. No. 10,479,694

PROCESS OF CLEAN PRODUCTION OF ELECTRONIC GRADE HIGH-PURITY COPPER OXIDE

1. A process of clean production of an electronic grade high-purity copper oxide, comprising the following steps in sequence:(1) continuously preparing a carbon-ammonia system solution, wherein the molar ratio of CO2:NH3:H2O is 1:1.3-2:17-20;
(2) adding the carbon-ammonia system solution into a reaction vessel preloaded with metallic copper, and constantly inputting air, oxygen or ozone under a negative pressure of between ?0.01 and ?0.02 Mpa to keep the temperature of the reaction system equal to or less than 60° C.; the negative pressure is closed when the concentration of copper in the carbon-ammonia system solution reaches 80-140 g/L;
(3) filtering the copper, carbon-ammonia system solution to a reaction kettle for deamination, adding sodium polyacrylate to obtain a reaction solution after stirring evenly; the reaction solution is heated to a temperature of 60-80° C. under a pressure of between ?0.03 and ?0.08 MPa for deamination and ammonia water is collected during deamination, wherein the sodium polyacrylate is added in an amount of 0.2-0.6 g/L based on a volume of the copper, carbon-ammonia system solution filtrate;
(4) separating solid from liquid by a centrifuge obtaining a copper carbonate including copper and collecting a copper-containing clear solution;
(5) calcining the copper carbonate at a temperature of 250-600° C. for 1-5 hours to give an electronic grade high-purity copper oxide, and carbon dioxide and water vapor are produced during the calcination; the ammonia water collected in the above step (3), the copper-containing clear solution collected in the step (4) and carbon dioxide and water vapor collected in the step (5) are directly used as raw materials to prepare the carbon-ammonia system solution, wherein the copper-containing clear solution is used as water.
US Pat. No. 10,483,544

LITHIUM SECONDARY BATTERIES

SK Innovation Co., Ltd., ...

1. A lithium secondary battery comprising: an anode containing agglomerate artificial graphite having pores with an average diameter of 80 to 150 nm; and an electrolyte solution having a viscosity of 5.0 cP or less at 25° C.,wherein the agglomerate artificial graphite satisfies the following Equation 1:
0.1??HA/HA?0.4
wherein HA is an average particle diameter (?m) of the agglomerate artificial graphite; and ?HA is an average particle diameter variation (?m) of the agglomerate artificial graphite when applying a pressure of 4 mN/cm2,
wherein the electrolyte solution contains a first solvent including ethylmethyl carbonate, diethyl carbonate or a mixed solution thereof and a second solvent including at least one selected from dimethyl carbonate (DMC), dipropyl carbonate (DPC), methylpropyl carbonate (MPC), ethylpropyl carbonate (EPC), ethylene carbonate (EC), propylene carbonate (PC), and butylene carbonate (BC).
US Pat. No. 10,483,546

USE OF XANTHAN GUM AS AN ANODE BINDER

National Research Council...

1. An electrode consisting essentially of: an electrode active material into which lithium is intercalated, a conductive carbon, and a binder; wherein the electrode active material is an oxide, or a homogeneous matrix of an oxide and a conductive carbon, and wherein the binder comprises xanthan gum.
US Pat. No. 10,478,417

FORMULATION FOR EFFECTIVE TOCOTRIENOL DELIVERY

KL-KEPONG OLEOMAS SDN BHD...

1. A method of delivering a tocotrienol to a subject in need of supplementing an intake of a daily allowance of a fat-soluble nutrient, the method comprising administering to the subject a dietary supplement comprising a self-emulsifying formulation comprising a fat-soluble compound selected from tocotrienols and derivatives thereof, wherein the amount of the fat-soluble compound is about 10% to about 50%, by weight of the formulation; two emulsifiers each selected from the group consisting of nonionic surfactants, wherein the emulsifiers are sorbitan monolaurate and polyoxyethylene sorbitan 20 monooleate (Polysorbate 80), wherein the amount of emulsifiers is about 15% to about 45%, by weight of the formulation, wherein the weight ratio of said sorbitan monolaurate to Polysorbate 80 is about 1:1 to about 1:20; andan oil carrier selected from the group consisting of glycerides, wherein the amount of oil carrier is about 6% to about 56%, by weight of the formulation.
US Pat. No. 10,479,955

LUBRICATING GREASE COMPOSITION

Nok Klueber Co., Ltd., T...

1. A lubricating grease composition for a resin member used to be supplied as a lubricant on a surface of at least a sliding portion of a resin member including the sliding portion with another member, wherein the lubricating grease composition for a resin member containsa base oil which consists of a mixed oil of: a poly-?-olefin having a kinetic viscosity at 40° C. of 18 to 30 mm2/s, and an ethylene-?-olefin copolymer having a number average molecular weight of 40,000 to 200,000,
a lithium-based complex soap as a thickener, and
a polytetrafluoroethylene resin as a solid lubricant having a mixing ratio of 4 to 12 mass % to the entire lubricating grease composition,
wherein the base oil, which is the mixed oil of the poly-?-olefin and the ethylene-?-olefin copolymer, has a kinetic viscosity at 40° C. of 80 to 200 mm2/s, and
a worked penetration of the lubricating grease composition ranges from 295 to 340.
US Pat. No. 10,478,418

INHIBITED EXPRESSION OF PD-L1 AND ENHANCED EXPRESSION OF PD-1

IN Ingredients, Inc., Sp...

1. A method of treating a glioma in a human in need thereof comprising administering to said human in need thereof a composition comprising at least 5.0 weight % isolated cinnamtannin D-1, at least 5.0 weight % isolated cinnamtannin B-1, or a combination thereof to effectively treat the glioma in said human in need thereof.
US Pat. No. 10,483,554

CARBON SUPPORT FOR FUEL CELL CATALYST AND PREPARATION METHOD THEREOF

KOREA INSTITUTE OF SCIENC...

1. A method for preparing a nitrogen-doped carbon support for a fuel cell catalyst, the method comprising:(A) mixing a conductive carbon support with a nitrogen-containing organic material;
(B) primarily annealing the mixture at 90 to 150° C. for 2 to 10 hours in a normal air atmosphere so as to react nitrogen atoms of the nitrogen-containing material with the support; and
(C) secondarily annealing the primarily annealed mixture at 600 to 750° C. under a nitrogen atmosphere
so as to completely dope the nitrogen atoms into the support.
US Pat. No. 10,479,962

SOLID COMPOSITION FOR TEXTILE TREATMENT

1. A solid composition for use in treatment of textiles comprising:a sodium percarbonate present as a powder or granules in a total amount of about 32% to about 55% by weight based on the total weight of the composition,
tetraacetylethylenediamine present in a total amount of from about 10% to about 20% by weight based on the total weight of the composition,
a sodium hydrogen carbonate present as a powder or granules in a total amount of from about 7.5 to about 30% by weight based on the total weight of the composition, and
a surfactant present in a total amount of from about 1 to about 3% by weight based on a total weight of the composition,
wherein the total amount of organic compound in the solid composition amounts to from about 10% to about 50% by weight, and
wherein the solid composition is free of sodium silicate.
US Pat. No. 10,483,555

FUEL CELLS USING VERTICALLY FREE STANDING GRAPHENE AND CARBON NANOSHEETS

1. A fuel cell, comprising:a cathode;
an anode; and
an electrolyte,
wherein a plurality of vertically free-standing graphene-containing carbon nanosheets, of which the thickness is 2 nanometers or less, having a base layer of planar one to seven atomic layers graphene materials, having folded and crumpled topological structure, grow up on surfaces of the cathode and/or the anode, by a plasma technology.
US Pat. No. 10,478,427

THERAPEUTIC AGENT FOR FIBROSIS AND INHIBITOR OF NUCLEAR TRANSLOCATION OF PHOSPHORYLATED SMAD

NATIONAL UNIVERSITY CORPO...

1. A method for treating fibrosis caused by nuclear translocation of phosphorylated Smad, wherein the fibrosis is idiopathic pulmonary fibrosis, comprising administrating a therapeutic agent for the fibrosis whose active ingredient is constituted by a glucosylceramide synthase inhibitor or lactosylceramide synthase inhibitor, or both, which inhibitor has the activity of inhibiting nuclear translocation of phosphorylated Smad and is contained in a therapeutically effective amount, said inhibitor(s) being a sole inhibitor or sole inhibitors administrated during and for treatment of the fibrosis.
US Pat. No. 10,478,946

OPEN MESH ABRASIVE MATERIAL

KEYON S.R.L., Verona (IT...

1. A process for the preparation of an open mesh abrasive material, comprising the following steps:a) impregnating only a second side of an open mesh support with a binder;
b) applying abrasive granules on said second side; and
c) drying the material obtained resulting in the open mesh abrasive material;
wherein a first side of the open mesh support is not-impregnated and is a teaseled side and wherein the second side of the open mesh support is the impregnated side and is a non-teaseled side.
US Pat. No. 10,483,049

LITHIUM ION CAPACITOR

TAIYO YUDEN CO., LTD., T...

1. A lithium ion capacitor having an electrolytic solution that contains:an electrolyte which is a mixture of LiFSI and LiBF4 which are the only lithium salts used as the electrolyte, where the mol ratio of LiFSI to LiBF4 is in a range of 90/10 to 30/70;
a solvent that contains at least one cyclic or chained carbonate compound; and
a film-forming agent which suppresses reductive decomposition of the solvent by reductively decomposing itself at a potential higher than that of the solvent, thereby forming a film on a negative electrode;
wherein a concentration of electrolyte in the electrolytic solution is in a range of 1.2 to 1.8 mol/L.
US Pat. No. 10,481,513

TONER FOR ELECTROSTATIC CHARGE DEVELOPMENT

KONICA MINOLTA, INC., To...

1. A toner for electrostatic charge development, comprising a toner particle, the toner particle comprising: a toner base particle containing a binder resin and a release agent; and an external additive containing titanium dioxide, whereinthe number fraction of the toner particle containing the titanium dioxide is 0.1% or more and 2.0% or less.
US Pat. No. 10,479,975

METHODS OF MAKING T CELL COMPOSITIONS

bluebird bio, Inc., Camb...

1. A method for manufacturing T cells comprising:a) activating a population of T cells and stimulating the population of T cells to proliferate;
b) transducing the T cells with a viral vector comprising a polynucleotide encoding an engineered T cell receptor (TCR) or a chimeric antigen receptor (CAR); and
c) culturing the transduced T cells to proliferate;
wherein steps a)-c) are performed in the presence of a phosphatidylinositol-3 kinase (PI3K) inhibitor, and
wherein T cell differentiation is decreased in the T cells manufactured according to steps a)-c) performed in the presence of the PI3K inhibitor compared to T cell differentiation in T cells manufactured according to steps a)-c) performed in the absence of the PI3K inhibitor.
US Pat. No. 10,479,977

OSTEOCHONDRORETICULAR STEM CELLS FOR BONE AND CARTILAGE REGENERATION

The Trustees of Columbia ...

1. A method of treating a disease, degeneration, or injury of bone, or cartilage, or both, in a subject comprising administering a therapeutically effective amount of a composition comprising an acceptable carrier and isolated osteochondroreticular (OCR) stem cells that express Grem1 to a site in need thereof in the subject, wherein the isolated OCR stem cells are at least about 70% pure.
US Pat. No. 10,479,981

DNASE VARIANTS

1. A DNase variant, comprising:a polypeptide having at least 90% sequence identity to SEQ ID NO: 1;
wherein the polypeptide includes an amino acid substitution at position 39 of SEQ ID NO: 1 that is S39V or S39R;
wherein the polypeptide has DNase activity; and
wherein the polypeptide has improved stability as compared to the polypeptide of SEQ ID NO: 1.
US Pat. No. 10,479,983

VARIANT ENZYMES

DANISCO US INC, Palo Alt...

1. A variant glycoside hydrolase family 61 (GH61) polypeptide, wherein said variant has cellulase enhancing activity, has at least 95% sequence identity to the amino acid sequence of SEQ ID NO:3 and the amino acid substitution I114L, and has at least one improved property relative to a parent GH61 polypeptide, wherein said improved property is selected from the group consisting of (a) expression based on protein level and RNA level or activity of the variant GH61 polypeptide, (b) thermostability and/or melting temperature (Tm), (c) performance in a Whole Hydrolysate Dilute Acid Pretreated Corn Stover (whPCS) hydrolysis assay.
US Pat. No. 10,479,984

POLYPEPTIDES HAVING CELLOBIOHYDROLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

1. A polypeptide comprising a carbohydrate binding module operably linked to a catalytic domain, wherein the carbohydrate binding module is heterologous to the polypeptide, and wherein the carbohydrate binding module is selected from the group consisting of:(a) a carbohydrate binding module having at least 95% sequence identity to amino acids 517 to 545 of SEQ ID NO: 2;
(b) a carbohydrate binding module comprising amino acids 517 to 545 of SEQ ID NO: 2; and
(c) a carbohydrate binding module encoded by a polynucleotide having at least 98% sequence identity to nucleotides 1549 to 1635 of SEQ ID NO: 1.
US Pat. No. 10,479,986

NUCLEIC ACID CONSTRUCTS AND METHODS FOR LABELING AND DETECTING NUCLEOSOMAL DNA MODIFICATIONS

The Broad Institute, Inc....

1. A method for labeling nucleic acids from a cell or population of cells comprising:providing one or more individual discrete volumes, each individual discrete volume comprising a cell or population of cells;
lysing the cell or population of cells in each individual discrete volume and fragmenting nucleosomal DNA from the lysed cell or population of cells;
labeling the fragmented nucleosomal DNA in each individual discrete volume with a barcoded adapter on at least one free end of the fragmented nucleosomal DNA, wherein:
the barcoded adapter comprises an amplification promoter adjacent to a first or second read sequencing primer binding site which is adjacent to a barcode sequence,
the labeled nucleosomal DNA comprises, in a 3? to 5? orientation, a first read sequencing primer binding site, the nucleosomal DNA sequence, the barcode sequence, and a second read sequencing primer binding site,
the barcode sequence is unique to each individual discrete volume thereby identifying a sample from which the labeled nucleosomal DNA originated;
isolating and sequencing the labeled nucleosomal DNA from each sample; and
grouping the sequenced nucleosomal DNA by common barcode thereby identifying the individual discrete volumes from which the nucleosomal DNA originated.
US Pat. No. 10,483,580

SOLID STATE FUEL CELL AND METHOD FOR MAKING THE SAME

National Taipei Universit...

1. A solid state fuel cell comprising an anode, a cathode, and a ceramic electrolyte including a silicate oxyapatite represented byREy?xMxSi6O27±?
where RE is a rare earth metal, M is an alkali metal, x is greater than 0 and less than 1, y ranges from 9.3 to 10, and ? ranges from 0 to 2.
US Pat. No. 10,479,988

METHOD OF MAKING A VACCINE

LUMAGENICS, LLC, Nashvil...

1. A method of producing a live or dead attenuated infectious cells comprising:a) isolating a plurality of infectious cells;
b) selecting a high energy UV light source that delivers a low heat UV containing light to the end of a light guide;
c) selecting the UV light source and output so that UV energy from the light source can selectively attenuate cells; and
d) exposing the infectious cells to the light from the end of the light guide at sufficient distance and wherein the cells are exposed to the light from about 0.1 seconds to about 5 seconds to attenuate the cells without damaging cellular proteins and carbohydrates that produce the immune response to produce attenuated cells.
US Pat. No. 10,479,733

POWDER COMPRISING POLYMER-COATED CORE PARTICLES COMPRISING METALS, METAL OXIDES, METAL NITRIDES OR SEMIMETAL NITRIDES

Evonik Degussa GmbH, Ess...

1. A powder, comprising composite particles:wherein the composite particles, comprise:
a core particle; and
a coating of a precipitated polymer on the core;
wherein
a thickness of the precipitated polymer coating of the composite particle is from 1.5 to 35 ?m,
the core particle is at least one material selected from the group consisting of a metal, a metal nitride, a semimetal nitride and a metal oxide selected from the group consisting of Al2O3, ZrO2, ZnO, Bi2O3, CeO2, ITO (indium oxide doped with tin(IV) oxide), having a d50 median diameter of from 1 to 100 ?m,
the precipitated polymer of the coating comprises at least one polymer selected from the group consisting of nylon-11, nylon-12, PA1010, PA1012, PA1212 and PA1013,
the melting point of the precipitated polymer in a first heating procedure is greater than in a second heating procedure, as measured by differential scanning calorimetry (DSC),
a ratio of a d50 median diameter of the composite particles to the d50 median diameter of the core particles is 1.15 to 30, and
the melting point of the precipitated coating polymer is obtainable when the polymer is exposed to an electromagnetic energy.
US Pat. No. 10,479,993

MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION

Ionis Pharmaceuticals, In...

1. A compound comprising a sodium salt of a single-stranded modified oligonucleotide consisting of 16 linked nucleosides having a nucleobase sequence consisting of SEQ ID NO: 245, and comprises:a gap segment consisting of ten linked deoxynucleosides;
a 5? wing segment consisting of 3 linked nucleosides; and
a 3? wing segment consisting of 3 linked nucleosides;
wherein the gap segment is positioned between the 5? wing segment and the 3? wing segment; wherein each nucleoside of each wing segment comprises a constrained ethyl nucleoside; wherein each internucleoside linkage of the modified oligonucleotide is a phosphorothioate linkage; and wherein each cytosine of the modified oligonucleotide is a 5-methylcytosine.
US Pat. No. 10,478,458

IN VITRO PRE-CONDITIONED BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AND USES THEREOF

THE JOHNS HOPKINS UNIVERS...

1. A composition comprising:an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (BMSCs),
wherein at least 80% of the in vitro pre-conditioned BMSC population express PGP9.5 and NSE,
wherein at least 70% of the in vitro pre-conditioned BMSC population express Tuj1 and HuC/D,
wherein at least 75% of the in vitro pre-conditioned BMSC population express neuronal nitric oxide synthase (nNOS), and
wherein the BMSCs promote de novo regeneration of neurons not originated from the BMSCs when the BMSCs are administered to a subject.
US Pat. No. 10,480,000

METHODS OF INCREASING CROP YIELD UNDER ABIOTIC STRESS

CERES, INC., Thousand Oa...

1. A method of increasing plant yield in a plant grown under drought stress, osmotic stress, or nitrogen deficiency, said method comprising:(a) growing plants transformed with an exogenous nucleic acid under drought stress, osmotic stress, or nitrogen deficiency, said exogenous nucleic acid comprising a heterologous promoter operably linked to a nucleotide sequence encoding a polypeptide having at least 95% amino acid sequence identity to the amino acid sequence as set forth in SEQ ID NO: 2; and
(b) selecting a transformed plant from said transformed plants that expresses said polypeptide and has increased yield when grown under drought stress, osmotic stress, or nitrogen deficiency as compared to the corresponding yield of a control plant of the same species that does not comprise said exogenous nucleic acid and grown under identical stress conditions.
US Pat. No. 10,479,746

METHOD FOR PRODUCING AND PURIFYING 2,3,3,3-TETRAFLUORO-1-PROPENE

ARKEMA FRANCE, Colombes ...

1. A process for purifying 2,3,3,3-tetrafluoro-1-propene (1234yf) using a first composition comprising 2,3,3,3-tetrafluoro-1-propene and at least one compound selected from the group consisting of 1,1-difluoroethane (152a), chloropentafluoroethane (115) and trans-1,3,3,3-tetrafluoro-1-propene (1234ze-E), said process comprising:a) placing said first composition in contact with at least one organic extracting agent to form a second composition;
b) distilling said second composition by extractive distillation to form:
i) a third composition comprising said organic extracting agent and said at least one compound selected from the group consisting of 1,1-difluoroethane (152a), chloropentafluoroethane (115) and trans-1,3,3,3-tetrafluoro-1-propene (1234ze-E); and
ii) a stream comprising 2,3,3,3-tetrafluoro-1-propene; and
c) recovering and separating said third composition to form a stream comprising said organic extracting agent and a stream comprising said at least one compound selected from the group consisting of 1,1-difluoroethane (152a), chloropentafluoroethane (115) and trans-1,3,3,3-tetrafluoro-1-propene (1234ze-E).
US Pat. No. 10,483,595

TUNGSTEN-BASED MATERIAL SUPER BATTERY AND SUPERCAPACITOR

SUZHOU HANS ENERGY STORAG...

1. An electrochemical energy storage and conversion device that comprises:an aqueous electrolyte solution; and
at least one of:
a tungsten carbon super battery having one electrode made of a tungsten material and another electrode made of carbon;
a tungsten and tungsten super battery having one electrode and another electrode that are each made of a tungsten trioxide material;
a tungsten lead oxide super battery having one electrode made of the tungsten trioxide material and another electrode made of lead oxide; and
a hybrid super battery that is constructed by the tungsten carbon super battery and the tungsten lead oxide super battery connected in parallel or in series,
wherein the tungsten material and the tungsten trioxide material are each at least one selected from the group consisting of:
(a) a hydrous tungsten trioxide (WO3.nH2O) having a crystal structure selected from the group consisting of a cubic crystal structure, a hexagonal structure, a bi-continuous structure, and combinations thereof, and wherein n is a value in the range of 0 (b) the hydrous tungsten trioxide of section (a), which is doped with an element A (AxWO3.nH2O), wherein the element A is at least one element selected from the group consisting of an alkali metal that is either sodium or potassium, an alkaline earth metal that is either calcium or strontium, a transition metal that is either titanium or zirconium, and a rare metal that is either lanthanum or cerium, and x is a value in the range of 0 (c) a mixture or composite material that consists of a tungsten-free material and at least one of the hydrous tungsten trioxide of section (a) and the hydrous tungsten trioxide of section that is doped with the element A of section (b), wherein the tungsten-free material is selected from the group consisting of:
a carbon material that is selected from the group consisting of carbon black, onion structured carbon particles, activated carbon, mesoporous carbon, carbon nanotubes, carbon nanofiber, graphite, graphene, graphene oxide, combinations thereof,
a polymer material that is selected from the group consisting of polyaniline, polypyrrole, polythiophene, poly (3,4-ethylenedioxythiophene), polystyrene, sulfonated polystyrene, and combinations thereof,
a metal or salt thereof that is selected from the group consisting of vanadium, chromium, zirconium, niobium, molybdenum, lead, bismuth, and combinations thereof, and
a ceramic material that is selected from the group consisting of zirconium oxide, silicon oxide, strontium oxide, aluminum oxide, and combinations thereof.
US Pat. No. 10,478,465

HERBAL COMPOSITION FOR THE TREATMENT AND MANAGEMENT OF CANCER AND METHOD OF PREPARATION THEREOF

Muniyal Ayurvedic Researc...

1. An oral composition comprising Vinca rosea, Aristolochia indica, Eclipta alba, Moringa oleifera, Curcuma longa and a therapeutically effective amount of Kajjali; wherein said composition is in a form selected from a group consisting of tablets, pellets, lozenges, granules, suspensions and capsules.
US Pat. No. 10,479,747

FIRE RETARDANT COMPOUNDS

The Boeing Company, Chic...

1. A fire extinguishing unit comprising a container and delivery system, the container containing a fire extinguishing compound having the formula:(F3C)C(R2)=CR3R4 whereinR2 is iodo and R3 and R4 are both fluoro or R3 is hydrogen and R4 is fluoro;
R2 is bromo, R3 is bromo and R4 is iodo; or
R2 is fluoro, R3 is chloro, and R4 is iodo.
US Pat. No. 10,478,466

TOPICAL VASODILATOR COMPOSITION

1. A topical composition comprising:(a) from about 0.05% to about 10.0% by weight of Arnica oil;
(b) from about 5.0% to about 20.0% by weight of a notoginseng herb comprising dammarane-type ginseno sides;
(c) from about 0.05% to about 10% by weight of a compound comprising cyclopentasiloxane, dimethicone crosspolymer, dimethicone/vinyl dimethicone crosspolymer, and dimethiconol;
(d) from about 0.05% to about 5.0% by weight cetearyl alcohol;
(e) from about 0.75% to about 0.85% by weight of a compound formed from diazolidinyl urea (“DU”) and iodopropynyl butylcarbamate (“IPBC”), wherein the ratio of DU to IPBC is substantially 99% to 1% by weight;
(f) about 0.05% to about 2.5% by weight of dimethyl sulfone;
(g) about 0.25% weight of phytonadione; and
a cosmetically acceptable aqueous carrier, wherein upon a topical application of the composition to a skin contusion region, such application promotes vasodilatation in the region and dissipation of the contusion, wherein the notoginseng herb comprising dammarane-type ginsenosides is selected from the group consisting of, Panax quinquefolius, Panax vietnamensis, and Panax notoginseng and mixtures thereof.
US Pat. No. 10,478,467

METHODS AND COMPOSITIONS ADDRESSING DEPRESSED MOOD

Centre for Addiction and ...

1. A method for treatment or prophylaxis of depressed mood in a subject experiencing excessive crying at up to 18-months postpartum, comprising administering to a subject in need thereof:an antioxidant source once daily on at least day-1 of a treatment regime of from 3 to 5 days; wherein the antioxidant source comprises an anthocyanin-containing fruit, vegetable, nut, legume, or a juice or extract thereof, and has an ORAC value of at least about 3000 ?mol TE/serving;
a tryptophan composition on the evening of the penultimate day of the treatment regime, simultaneously or following the antioxidant source, said tryptophan composition comprising from 1.0 g to 5.0 g of L-tryptophan per serving in free amino acid form, and acceptable diluents; and
a tyrosine composition on the final day of the treatment regime, said tyrosine composition comprising from 2.0 g to 50 g of L-tyrosine per serving in free amino acid form, and acceptable diluents.
US Pat. No. 10,480,005

SOYBEAN VARIETY 5PEKB42

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 5PEKB42, wherein a sample of seed of said variety has been deposited under ATCC Accession No. PTA-126130.
US Pat. No. 10,478,468

METHOD FOR ENHANCING EFFECT OF IMMUNOTHERAPY FOR CANCER

PHYTOHEALTH CORPORATION, ...

1. A method for increasing a subject's pool of M1 macrophages, wherein the subject is suffering from one or more conditions associated with undesirable M2 macrophage activation, the method comprisingadministering to the subject an effective amount of a polysaccharide extract of Astragalus membranaceus, said polysaccharide extract comprising an arabinose:galactose ratio ranging from about 1.5:1 to about 3:1; from about 5% to about 15% arabinose; less than about 1.5% rhamnose; from about 3% to about 7% galactose; less than about 4% galacturonic acid; and, from about 70% to about 90% glucose.
US Pat. No. 10,479,751

PROCESS FOR PREPARING ACRYLIC ACID

Evonik Degussa GmbH, Ess...

1. An apparatus consisting essentially ofa feed containing a reaction mixture arranged below the middle of the apparatus,
a quenching agent inlet arranged above the feed,
an outlet arranged below the feed and
a draw arranged above the quenching agent inlet,the apparatus having, between the quenching agent inlet and the feed containing the reaction mixture, a region provided with one or more packing elements, wherein 2 or 3 sieve trays or ripple trays which ensure the formation of a liquid layer having a height of at least 1 cm is present between the quenching agent inlet and a packing element present between the quenching agent inlet and feed containing the reaction mixture, the liquid layer being arranged in the apparatus such that gaseous substances which pass through the feed containing the reaction mixture into the apparatus have to pass through the liquid layer in order to get into the top of the apparatus.
US Pat. No. 10,480,007

INSECTICIDAL PROTEINS FROM PLANTS

PIONEER HI-BRED INTERNATI...

1. A recombinant PtIP-50 polypeptide comprising an amino acid sequence having at least 95% sequence identity, across the entire length of the amino acid sequence, compared to the amino acid sequence of SEQ ID NO: 71, wherein the PtIP-50 polypeptide has insecticidal activity against Soy Bean Looper, Corn Earworm, European Corn Borer or Velvet Bean Caterpillar in combination with a PtIP-65 polypeptide comprising an amino acid sequence having at least 95% identity to SEQ ID NO: 22, wherein the PtIP-50 polypeptide is operably linked to a heterologous signal or leader sequence.
US Pat. No. 10,478,471

IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER

IMMATICS BIOTECHNOLOGIES ...

1. A method of treating a patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer, comprising administering to said patient a composition comprising a population of activated T cells that selectively recognize cells in the patient that aberrantly express a peptide, wherein said peptide consists of the amino acid sequence of VFIFKGNQF (SEQ ID NO: 18), wherein the peptide is in a complex with an MHC molecule.
US Pat. No. 10,478,474

THYMOSIN ALPHA 1 FOR USE IN TREATMENT OF CYSTIC FIBROSIS

SciClone Pharmaceuticals ...

1. A method of treating cystic fibrosis in a patient comprising administering a pharmaceutical composition comprising Thymosin alpha 1 to the patient, wherein the patient has a cystic fibrosis transmembrane conductance regulator (CFTR) mutation ?F508.
US Pat. No. 10,480,012

CYP-P22 BIOCATALYTIC NANOPARTICLES WITH CYTOCHROME P450 ACTIVITY FOR PRODRUG ACTIVATION

UNIVERSIDAD NACIONAL AUTO...

1. An immunologically inert and functionalized CYP-P22 biocatalytic nanoparticle that activates prodrugs in a target cell, comprisinga) a polypeptide sequence of SEQ ID NO:4 which is a fusion of a scaffold protein SP and a CYPBM3 protein,
b) a fragment of a P22 scaffold protein,
c) a coat protein of P22 bacteriophage,
d) a bifunctional dendritic polyethylene glycol, and
e) a cyclic polypeptide of SEQ ID NO: 5.
US Pat. No. 10,478,477

METHOD FOR PROPHYLAXIS OR TREATMENT OF ERBB1 POSITIVE CANCERS USING A VARIANT PEPTIDASE D WITH REDUCED ACTIVITY

Health Research, Inc., B...

1. A method for prophylaxis or therapy of ErbB1-positive cancer in an individual comprising administering to the individual an effective amount of a composition comprising peptidase D (PEPD), the PEPD comprising the sequence of SEQ ID NO:1 with a mutation of G278, such that growth of the ErbB1-positive cancer is inhibited.
US Pat. No. 10,479,760

SYNTHETIC METHODS FOR THE PREPARATION OF PROPYLENE AMMOXIDATION CATALYSTS

Clariant Corporation, Lo...

1. A process for producing a catalyst material, the catalyst material comprisingan inert carrier having a specific surface of 1 to 500 m2/g in an amount in the range of about 25 wt % to about 75 wt %, and
a metal oxide catalyst in an amount in the range of about 25 wt % to about 75 wt %, the metal oxide catalyst having the formula MoxBiyFezNiaCeb1Mab2Mnb3Kd1Csd2Ov, wherein
x is in the range of 12 to 14;
y is in the range of 0.05 to 0.4;
z is in the range of 1 to 2.5;
a is in the range of 5 to 7;
b1 is in the range of 0.2 to 0.6;
b2 is in the range of 1 to 3;
b3 is in the range of 0.1 to 1.0;
d1 is in the range of 0.01 to 0.15;
d2 is in the range of 0.01 to 0.8; and
v is the number of oxygen atoms required to satisfy the valence requirements of the other component elements Mo, Bi, Fe, Ni, Ce, Mg, Mn, K, and Cs,the process comprising:providing a metal oxide precursor fluid comprising a solvent in admixture with a plurality of metal oxide precursors, the plurality of metal oxide precursors comprising at least
a molybdenum oxide precursor,
a bismuth oxide precursor, and
an iron oxide precursor,
wherein less than about 20 wt % of each of the molybdenum oxide precursor, the bismuth oxide precursor, and the iron oxide precursor is not dissolved in the solvent;
impregnating the inert carrier with the metal oxide precursor fluid to provide impregnated carrier;
drying the impregnated carrier to provide a dried, impregnated carrier; and
heating the dried, impregnated carrier to provide the catalyst material.
US Pat. No. 10,478,479

METHOD FOR PREPARING DENDRITIC CELL, DENDRITIC CELL PREPARED THEREBY, AND USE THEREOF

JW CREAGENE INC., Gyeong...

1. A method for preparing a dendritic cell, comprising:culturing an immature dendritic cell to a mature dendritic cell with treating by 1-10 ng/mL of rapamycin and a maturation factor; and
after maturation of the immature dendritic cell to the mature dendritic cell has been completed, sensitizing the mature dendritic cell with an antigen bound to a peptide having cell permeability,
wherein said sensitizing of the mature dendritic cell with the antigen bound to the peptide having cell permeability is performed at least 6 hours and up to 48 hours after said treating by the maturation factor, and
wherein said sensitizing of the mature dendritic cell with the antigen bound to the peptide having cell permeability is performed for 1 to 8 hours.
US Pat. No. 10,481,301

NANOMETRIC TIN-CONTAINING METAL OXIDE PARTICLE AND DISPERSION, AND PREPARATION METHOD AND APPLICATION THEREOF

Xiamen Nanotech Co Ltd, ...

1. A method for preparing a dispersion of tin-containing metal oxide nano-particles, wherein the tin-containing metal oxide comprises tin element and an aid metallic element other than tin selected from antimony, indium, titanium, copper, zinc, zirconium, cerium, yttrium, lanthanum, niobium or a mixture thereof; and the tin-containing metal oxide nano-particles have an initial average particle diameter of 2-50 nm, a particle diameter distribution as defined with an Index of dispersion degree of less than 7 and a steepness ratio of less than 3, the method comprises steps of:(1) reacting a solution containing tin ions and a solution containing ions of the aid metallic element other tin with a solution of precipitating agent at a temperature of less than 100° C. under a non-acidic condition in an aqueous medium comprising at least one of alcohols, amides, ketones, epoxides and mixtures thereof to form tin-containing metal oxide precursor particles and a first by-product in ionic form; wherein the precipitating agent is selected from alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal carbonates, alkaline earth metal carbonates, alkali metal bicarbonates, ammonia, organic bases and mixtures thereof;
(2) separating the tin-containing metal oxide precursor particles from the first by-product in ionic form to obtain tin-containing metal oxide precursor particles substantially free of ionic impurities;
(3) reacting the tin-containing metal oxide precursor particles substantially free of Ionic impurities with an oxidizing agent or a reducing agent at a temperature of 150-400° C. and a pressure of 5 to 10 atmospheres to obtain tin-containing metal oxide particles and a second by-product in ionic form;
(4) coating the tin-containing metal oxide particles with a surfactant in an amount of 0.01% to 30% relative to the weight of tin-containing metal oxide particle to obtain coated tin-containing metal oxide particles, wherein the surfactant is selected from a non-silane surface modifying agent, a silane coupling agent, a titanate coupling agent, or a mixture thereof, and the non-silane surface modifying agent is selected from cationic surfactants, non-ionic surfactants, polymeric surfactants and mixtures thereof;
(5) separating the coated tin-containing metal oxide particles from the second by-product in ionic form to obtain tin-containing metal oxide nano-particles substantially free of ionic impurities;
(6) adding a dispersion medium and a dispersing agent to the tin-containing metal oxide nano-particles substantially free of Ionic impurities to obtain the dispersion of tin-containing metal oxide nano-particles,
wherein, when the dispersion medium is water in step (6), the dispersing agent is one or more selected from ethanolamine, triethanolamine, triethylamine, diisopropanol amine, tetramethylammonium hydroxide, polyvinyl alcohol, methacryloxy silane, polyacrylic acid ammonium salt dispersing agent, polyacrylic acid sodium salt dispersing agent, polysiloxane dispersing agent, polyamide dispersing agent, polymer block copolymer dispersing agent; and when the disperse medium is an organic solvent the dispersing agent is one or more selected from octylamine, polycarboxylic salt dispersing agents, polycarboxylic-sulfonic copolymer dispersing agents, polymaleicanhydride copolymer dispersing agents, silane coupling agents, titanate coupling agents.
US Pat. No. 10,478,483

COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEINS

GLAXOSMITHKLINE BIOLOGICA...

1. An immunogenic composition which comprises an immunologically effective amount of an adjuvant, an immunologically effective amount of a first isolated factor H binding protein (fHbp) antigen and an immunologically effective amount of a second isolated fHbp antigen, wherein: the first isolated fHbp antigen comprises a first amino acid sequence which has at least 75% sequence identity to both of SEQ ID NO: 1 and SEQ ID NO: 23, but the first amino acid sequence has a higher sequence identity to SEQ ID NO: 1 than to SEQ ID NO: 23, when aligned using the same algorithm and parameters; and the second isolated fHbp antigen comprises a second amino acid sequence which has at least 75% sequence identity to both of SEQ ID NO: 1 and SEQ ID NO: 23, but the second amino acid sequence has a higher sequence identity to SEQ ID NO: 23 than to SEQ ID NO: 1, when aligned using the same algorithm and parameters.
US Pat. No. 10,480,021

METHODS FOR CLOSED CHROMATIN MAPPING AND DNA METHYLATION ANALYSIS FOR SINGLE CELLS

YALE UNIVERSITY, New Hav...

1. A method of identifying regions of methylated genomic DNA in a double stranded genomic DNA sample, the method comprising sequentially:(a) digesting a double stranded genomic DNA sample with one or more methylation sensitive restriction endonucleases (MSREs), thereby forming digested, unligated DNA fragments;
(b) amplifying the digested, unligated DNA fragments by multiple displacement amplification (MDA), thereby producing a plurality of heterogeneous amplicons, the MDA comprising denaturing the digested, unligated DNA fragments and forming single stranded DNA fragments, annealing random primers to the single stranded DNA fragments, and extending the primers annealed to the single stranded DNA fragments with a polymerase;
(c) sequencing the amplicons; and
(d) identifying the regions of methylated genomic DNA in the double stranded genomic DNA sample based on the sequences of the amplicons.