US Pat. No. 10,334,825

HARNESS FOR PETS

FERPLAST S.P.A., Castelg...

1. A harness for pets, comprising a first front element designed to be fitted on a chest area of a pet, a second rear element designed to be fitted on an abdominal area of the pet, and a third element connecting the first and second elements and being designed to be fitted on a hack of the pet, wherein the first front element and the second rear element respectively comprise a pair of shaped elongated strips, namely a front strip and a rear strip, and wherein each end of the front strip is connected to a corresponding end of the rear strip via a coupling that allows these strips to move with respect to each other, adapting anatomically to a body of the pet and thereby forming a harness suitable for pets of different sizes, wherein the third element is constituted by a connecting tape or cord provided with a fastener that can be opened to allow the harness to be fitted on the body of the pet, and wherein the fastener consists of a ratchet and rack device.

US Pat. No. 10,334,824

MULTI-FUNCTIONAL RECONFIGURABLE PET ENRICHMENT SYSTEM

1. A pet enrichment system, comprising:a base layer comprising an upper surface that is made substantially of a reshapable, pliable first material;
a top layer, comprising:
at least three openings;
an upper surface that is made substantially of a reshapable, pliable second material, wherein the first material does not attach to the first material when the first material comes into contact with the first material, the first material does not attach to the second material when the first material comes into contact with the second material, and the second material does not attach to the second material when the second material comes into contact with the second material, such that the upper surface of the top layer and the upper surface of the base layer do not attach to the upper surface of the top layer nor to the upper surface of the base layer; and
a lower surface that is made substantially of a third material that does not attach to the first material when the third material comes into contact with the first material, that does not attach to the second material when the third material comes into contact with the second material, and that does not attach to the third material when the third material comes into contact with the third material, such that the lower surface of the top layer does not attach to the upper surface of the top layer, to the upper surface of the base layer, nor to the lower surface of the top layer; and
a plurality of semi-permanent hook tape fasteners affixed on the lower surface of the top layer,
wherein the fasteners attach to the first material when the fasteners come into contact with the first material at any location on the first material and to the second material when the fasteners come into contact with the second material at any location on the second material, and do not attach to the third material when the fasteners come into contact with the third material, such that the top layer only attaches at any location on the upper surface of the top layer and the upper surface of the base layer via the plurality of semi-permanent fasteners affixed on the lower surface of the top layer,
wherein some of the plurality of fasteners are distributed on the lower surface of the top layer around substantially a perimeter of the top layer, some of the plurality fasteners are affixed on the lower surface of the top layer substantially in each corner of the top layer, and at least one of the plurality fasteners is affixed on the lower surface of the top layer between two or more of the at least three openings,
wherein the top layer is configured to hold a three-dimensional shape, capable of forming a self-standing internal cavity with space suitable for containing a domestic cat or substantially similar sized animal in the case that at least some of the plurality of fasteners are attached to the first material of the base layer or to the second material of the top layer, and
wherein the plurality of fasteners are configured to release the first material of the base layer in response to a force pulling the fasteners away from the first material and to release the second material of the top layer in response to a force pulling the fasteners away from the second material.

US Pat. No. 10,334,823

FUNCTIONAL COMMUNICATION LEXIGRAM DEVICE AND TRAINING METHOD FOR ANIMAL AND HUMAN

1. A method of training a non-verbal animal to initiate communication and express choices to humans through operant conditioning processes including reinforcement, shaping a preliminary response, teaching discriminated associations, and training discriminative responses, said method comprising:providing a lexigram device comprising an assembly having a plurality of buttons in a fixed array, wherein each button is independently programmable to initiate a signal detectable by humans;
wherein said assembly comprises a casing comprising said buttons and a removable cover, wherein the cover can be placed over the plurality of buttons to protect the device when the device is not in use;
allowing the animal to approach the device;
engaging the animal and repeatedly prompting the animal to apply pressure to one of the plurality of buttons and providing a positive reinforcement corresponding to the particular button the animal has applied pressure to;
repeating the step of engaging the animal until the animal applies pressure to the button without prompting, so that the animal becomes conditioned to applying pressure to certain buttons to receive a corresponding positive reinforcement associated with that button;
providing the animal with access to the device so that the animal is able to operate the device autonomously or when prompted by the human.

US Pat. No. 10,334,822

BEHAVIORAL TRAINING AID

1. A behavioral training aid system comprising:(I) a behavioral training and comprising:
a. a body;
b. a tract including:
i. a tract locking mechanism that secures the tract to an outer surface of the body; and
ii. a tract insert removably attached to the tract locking mechanism, wherein the tract insert is configured to receive a receptacle so that the receptacle is elongated and forms a depository within the body;
c. one or more legs extending from the body; and
d. one or more base supports extending from a distal end of the one or more legs; and
(II) a push rod comprising a head mounted to a distal end of a shaft configured to elongate the receptacle, wherein the head of the shaft is inserted into the receptacle and pushed to elongate the receptacle until an end of the receptacle is secured by a receptacle securing mechanism.

US Pat. No. 10,334,821

RAINCOAT FOR DOGS

1. A raincoat (100) for dogs (200), comprising:a body portion (10) that substantially covers and extends from a rump (210) to a head (220) of a dog (200), wherein the body portion (10) is waterproof and the body portion (10) comprises a front edge (11), first and second front side edges (12 and 13), first and second side edges (14 and 15) and a rear edge (16);
a visor (20) fixedly attached to the front edge (11) of the body portion (10);
first and second pliable metal wires (31 and 32) that are parallel to each other and attached to the body portion (10) along a spinal line (230) of the dog (200), wherein the first and second pliable metal wires (31 and 32) substantially extend continuously from the front edge (11) of the body portion (10) to the rear edge (14) of the body portion (10); and
a fastening means (50) for fastening and securing the raincoat (100) to the dog (200).

US Pat. No. 10,334,820

METHOD FOR DISPLAYING INFORMATION ON AN ANIMAL AND FOR LOCATING AN ANIMAL

1. A method for locating an animal on which a display apparatus is arranged, and/or for displaying information on the animal, wherein information which is to be displayed is activatable and/or adjustable in and/or on the display apparatus (2), wherein a specific display is assigned to an animal in order to identify animals for selection, wherein a pushbutton key on the display apparatus (2) is used for acknowledgement by a user, and wherein a counterweight (8) is assigned to the display apparatus (2).

US Pat. No. 10,334,819

STORAGE BAG WITH JOINED CENTER PORTION

1. A flexible storage bag comprising:a front wall having a front top edge, a front bottom edge, a front left edge and a front right edge, the front wall comprising a flexible sheet material;
a back wall having a back top edge, a back bottom edge, a back left edge and a back right edge, the back wall comprising the flexible sheet material; and
a dispensing orifice;
wherein (i) the back wall is one or both of adhesively or thermally bonded to the front wall along at least two respective edges of the front and back walls, and (ii) the dispensing orifice is attached to one or both of the front and back walls permitting ingress and egress of a liquid into and out of the storage bag;
wherein portions of the front wall that are one or both of adhesively or thermally bonded to the back wall that do not include edges of the walls consist of a joined center portion proximate a center of the front wall and the back wall.

US Pat. No. 10,334,818

ROTARY LIVESTOCK FEEDER WITH GRAVITY FLOW FEED OPENINGS

Osborne Industries, Inc.,...

1. A feeder for dispensing feed to livestock, comprising:a trough;
a hopper mounted above said trough, said hopper including a bottom, a central feed discharge hole through said bottom, and at least one gravity flow feed opening through said bottom;
a deflector mounted in said hopper above said hopper bottom and vertically spaced from said hopper bottom, said deflector covering said central feed discharge hole to restrict gravity flow of feed from said hopper through said central feed discharge hole, said gravity flow feed opening being located outwardly of said deflector so that said deflector does not obstruct or restrict gravity flow of feed through said gravity flow feed opening;
a sweep member mounted for rotation about a vertical axis, said sweep member being located between said deflector and said hopper bottom for sweeping feed to said central feed discharge hole to discharge therethrough into said trough, said sweep member being operably coupled with a feed wheel disposed below said hopper in said trough so that animal-induced rotation of said feed wheel in said trough causes rotation of said sweep member in said hopper for sweeping feed to said central feed discharge hole for discharge into said trough;
a closure system associated with said gravity flow feed opening, said closure system having at least one door arranged to selectively cover said gravity flow feed opening, said closure system having a stationary open condition in which said door does not cover or obstruct said gravity flow feed opening to thereby allow unobstructed gravity feed flow through said opening into said trough, and a closed condition in which said door covers said gravity flow feed opening to obstruct gravity feed flow through said opening; and
an activator mechanism associated with said feed wheel that is arranged to cause said door of said closure system to change from said open condition to said closed condition upon rotation of said feed wheel.

US Pat. No. 10,334,816

DUAL-PURPOSE CONTAINER AND DIVERSION DEVICE FOR ANIMALS AND A METHOD FOR ITS MANUFACTURE

1. A dual-purpose container and diversion device for animals, the dual-purpose device comprising:a base having a perimeter, a lower surface and an upper surface, the base having a first tensile strength;
a perimeter wall including a plurality of sides of the dual-purpose container, the perimeter wall having a lower edge, an interior surface, and an exterior surface, wherein:
the perimeter wall has a second tensile strength;
the lower edge is attached to the perimeter of the base;
the lower surface of the base and the exterior surface of the perimeter wall combine to define an outer surface of the dual-purpose device;
the upper surface of the base and the interior surface of the perimeter wall combine to form an inner surface of the dual-purpose device; and
the inner surface and the outer surface combine to form an overall surface of the dual-purpose device;
at least a first linear fault region in the overall surface, wherein the at least a first linear fault region defines a first non-intersecting open curve on the overall surface, wherein:
the at least a first linear fault region has a third tensile strength;
the third tensile strength is less than each of the first tensile strength and the second tensile strength; and
the at least a first linear fault region defines a border of at least a first planar section of the overall surface;
at least a second linear fault region in the overall surface, wherein the at least a second linear fault region defines a second non-intersecting open curve on the overall surface, wherein:
the at least a second linear fault region has a fourth tensile strength;
the fourth tensile strength is less than the first tensile strength and the second tensile strength; and
the at least a second linear fault region defines a border of a second planar section of the overall surface;
wherein the dual-purpose device is convertible from a first configuration to a second configuration, and wherein:
the dual-purpose device is transformed to the second configuration by:
fracture of the at least a first linear fault region to transform the first planar section into a first flap;
fracture of the at least a second linear fault region to transform the second planar section into a second flap;
rotation of the first flap and the second flap into an interior compartment of the container; and
joining the first flap and the second flap to form a structural wall within the interior compartment.

US Pat. No. 10,334,795

UTILIZATION OF IRRIGATION WATER SAVER

1. A method of reducing the amount of water used in irrigation of a tree/plant comprising:placing an irrigation water saving device under a source of irrigation water into the ground near and in proximity to said tree/plant, wherein the device is made of mixed biomass of raw material components, in at least one of a round shape and a square shape with a dimension selected from the group consisting of 4 cm, 6 cm, and 8 cm in diameter, according to an agricultural season and is manufactured by crushing and mixing at a calculated rate, drying and then pressing the biomass into a cylinder shape that is hollow inside, said placing comprising placing the device at:
a depth for a large tree up to 100 cm, a depth for a medium tree up to 50 cm, and a depth for a plant other than a large or a medium tree up to 25 cm;
a length/size for a large tree of 25 cm or longer, a length/size for a medium tree up to 25 cm, and a length/size for a plant other than a large or medium tree up to 10 cm;
a number for a large tree of 2 to 4 devices or more, a number for a medium tree of 1 to 2 devices, and a number for a plant other than a large or medium tree to a minimum of 1 device;
wherein the method of reducing the amount of water used in irrigation wherein said device has a water absorbing ability up to 300%, which is greater than a water absorbing ability of sandy soil, such that when the device fully absorbs the water, the water then will permeate to said tree/plant through the sandy soil when a daily ration of irrigation stops and the sandy soil surrounding the device starts to get dry.

US Pat. No. 10,334,790

SUBSTRATE AUTO-PAVER FOR TABLE-TOP CULTURE

JIANGSU UNIVERSITY, Jian...

1. A substrate auto-paver for table-top culture machines for packing materials, transportation, and paving, the substrate auto-paver comprising the following components:a moving car, an automatic oblique pulling-type substrate-packing device, a substrate box, a substrate material in a cabinet, a floating-support-type double-side blanking device, and a uniform discharging device; a matrix box installed on the moving car, and a diagonal matrix automatic boxing device installed in the back side of the matrix box; the matrix box is installed between the substrate material in the cabinet and the double-side blanking device; the uniform discharging device is installed below the double-side blanking device;
the substrate material in the cabinet includes a bending-type scraper feeder, a dc motor, and a thin tension wheel; the bending-type scraper feeder has a lower part and an upper part;
the double-side blanking device comprises the matrix box, a floating trough, a push plate, a flat, a straight-moving element-mounting plate, and a level of a vertical slide rail; the front of the matrix box has two left and right symmetrical oblique dropping grooves; inside the matrix box and perpendicular to the two left and right symmetrical oblique dropping grooves, a plate is set; two floating chutes are set along the vertical slide rail and a horizontal slide rail symmetrically arranged in a substrate in front of the matrix box; an oblique chute below an opening is connected to a floating chute above the opening; a direct-moving element is vertically arranged on the straight-moving element-mounting plate along a central line of the front of the matrix box; the flat is installed at the end of the direct-moving element; and
a copying discharging device comprises a flexible scraper and a mixing mechanism for even spreading; the mixing mechanism includes a support member and a bearing, a drive shaft, and a thick elastic sleeve; the drive shaft is fixed and has two evenly spread parts, and a compact elastic sleeve is installed between the bearing and the two evenly spread parts.

US Pat. No. 10,334,789

PLANT ILLUMINATION DEVICE

VALOYA OY, Helsinki (FI)...

1. A lighting system, comprising:a housing defining a dark cavity with zero sunlight therein; and
at least one horticultural lighting fixture comprising
a) a first emission source comprising at least one light emitting diode (LED) and/or quantum dot emitting main spectral characteristics in the photosynthetically active radiation (PAR) (400-700 nm) area, the main spectral characteristics comprising at least two spectral peaks with non-zero emission intensity, and
b) a second emission source comprising at least one light emitting diode (LED) and/or quantum dot emitting at least one side spectral characteristics selected from first spectral characteristics in the 700-800 nm area, and second spectral characteristics in the 300-400 nm area, the at least one side spectral characteristics comprising at least one spectral peak with non-zero emission intensity.

US Pat. No. 10,334,788

BALER WITH MASS FLOW SENSING ASSEMBLY AND METHOD OF INITIATING STUFFER TRIP

IOWA STATE UNIVERSITY RES...

1. A baler comprising:a compression system for forming a bale;
a feed system including a loading fork assembly, the loading fork assembly including
a fork member having a fork bar with a plurality of forks extending therefrom, and
at least one arm coupled to the fork bar, the at least one arm movable in a pack mode for accumulating a crop in a pre-compression chamber and in a lift mode for conveying the crop to the compression system, wherein the pre-compression chamber includes an upstream half and a downstream half relative to the direction of crop movement downstream toward the compression system;
a sensor arrangement including at least one sensor generating a signal, the at least one sensor being coupled to the loading fork assembly, wherein the signal corresponds to a crop load on the loading fork assembly; and
a control unit configured to receive the signal from the sensor arrangement, wherein the control unit is configured to control operation of the at least one arm based on at least the signal from the loading fork assembly meeting a threshold when the plurality of forks are in the upstream half of the pre-compression chamber.

US Pat. No. 10,334,787

DEVICE FOR CONTROLLING THE OUTLET FLAP OF A BALER AND METHOD THEREOF

1. A device for controlling an outlet flap of a baler in at least one manual and one automatic mode, comprising:an outlet flap drive;
a first and a second pressure line via which the outlet flap drive is selectively charged with pressure;
a first pressure measuring means operatively connected to the first pressure line and a second pressure measuring means operatively connected to the second pressure line, the first and second pressure measuring means configured to determine a pressure in each respective pressure line; and
a distributor valve connected to the first and second pressure lines downstream of the first and second pressure measuring means;
wherein, the distributor valve comprises at least a first pass-through position, a second pass-through position, and a shut-off position;
wherein, in the at least one automatic mode, the distributor valve is disposed in a predetermined position dependent on a pressure difference between the pressures in the first and second pressure lines.

US Pat. No. 10,334,786

BALE ACCUMULATOR AND BALE ACCUMULATION METHODS

1. A bale accumulator for grouping rectangular bales for group baling, comprising:a depositor mounted adjacent to a platform for sequentially depositing bale sets onto the platform, each bale set when deposited onto the platform being a pair of rectangular bales positioned upright and side-by-side in a packing orientation with their corresponding long sides being axially juxtaposed;
a packer apparatus mounted adjacent to the platform for packing one bale set at a time from the platform into a bundler trailing the platform each time a bale set is deposited onto the platform from the depositor;
the depositor comprising:
an inlet;
an outlet adjacent to the platform;
a first bale-receiving area and a second bale-receiving area on either side of a divider between the inlet and the outlet, a first entrance to the first bale-receiving area, and a second entrance to the second bale-receiving area;
a gate mounted to the divider for movement between a first position and a second position, the gate including a first diverting arm, a second diverting arm, and a trigger arm;
the first diverting arm extends into the first bale-receiving area, the second diverting arm closes the first entrance to the first bale-receiving area from the inlet leaving the second entrance to the second bale-receiving area open to the inlet for enabling a rectangular bale to drop into the second bale-receiving area through the second entrance from the inlet, and the trigger arm extends into the second bale-receiving area in a path of rectangular bales through the second bale-receiving area, when the gate is in its first position;
the second diverting arm extends into the second bale-receiving area, the first diverting arm closes the second entrance to the second bale-receiving area from inlet leaving the first entrance to the first bale-receiving area open to the inlet for enabling a rectangular bale to drop into the first bale-receiving area through the first entrance from the inlet, and the trigger arm extends into the first bale-receiving area in a path of rectangular bales through the first bale-receiving area, when the gate is in its second position;
each time a rectangular bale passes through the second bale-receiving area when the gate is in the first position it strikes the trigger arm in the second bale-receiving area rotating the gate from the first position to the second position in response moving the trigger arm out of the path of rectangular bales through the second bale-receiving area for enabling the rectangular bale to drop onto the platform through the outlet from the second bale-receiving area; and
each time a rectangular bale passes through the first bale-receiving area when the gate is in the second position it strikes the trigger arm in the first bale-receiving area rotating the gate from the second position to the first position in response moving the trigger arm out of the path of rectangular bales through the first bale-receiving area enabling the rectangular bale to drop onto the platform through the outlet from the first bale-receiving area.

US Pat. No. 10,334,785

HEMP HARVESTER

1. A method for harvesting plants of the hemp genus, hemp stems being cut off above ground and flowers of the hemp plant being stripped from the stems, wherein(a) at least one pair of counter-rotating rollers (7) of a device for harvesting hemp are aligned along the direction of travel, and wherein the rollers are pressed against each other and pull the hemp stems downwards to the ground; and
(b) at least a pair of circumferential chains (9) of the device for harvesting hemp located above the at least one pair of rollers (7) which holds the hemp stem below the flowers and pulls the flowers backwards in a chain gap.

US Pat. No. 10,334,784

STRIPPER PLATE SYSTEM WITH BIASING FORCES

CNH Industrial America LL...

1. A stripper plate system, comprising:a frame;
a first stripper plate movably mounted to the frame, the first stripper plate comprising an elongated body with a proximal end, a distal end, a first lateral side, and a second lateral side;
a second stripper plate movably mounted to the frame in an opposing orientation to the first stripper plate, the second stripper plate comprising an elongated body with a proximal end, a distal end, a first lateral side, and a second lateral side, the second stripper plate being movably mounted to the frame such that the first lateral side of the second stripper plate faces the first lateral side of the first stripper plate and forms an elongated gap between the first and second stripper plates, and the elongated gap comprises a proximal end and a distal end;
a first tensioning mechanism mounted at or near the proximal end of the first stripper plate and biasing the proximal end of the first stripper plate toward a center of the elongated gap;
a second tensioning mechanism mounted at or near the distal end of the first stripper plate and biasing the distal end of the first stripper plate toward the center of the elongated gap;
a third tensioning mechanism mounted at or near the proximal end of the second stripper plate and biasing the proximal end of the second stripper plate toward the center of the elongated gap; and
a fourth tensioning mechanism mounted at or near the distal end of the second stripper plate and biasing the distal end of the second stripper plate toward the center of the elongated gap;
wherein a biasing force of the first and third tensioning mechanisms is lower than a biasing force of the second and fourth tensioning mechanisms such that a lower biasing force is imparted at the proximal end of the first and second stripper plates than the biasing force imparted at the distal end of the first and second stripper plates; and
wherein the first and second stripper plates are configured to move laterally upon contact with crop introduced into the elongated gap.

US Pat. No. 10,334,783

STALK ROLL FOR AGRICULTURAL ROW UNIT

CNH Industrial America LL...

1. An agricultural harvester row unit driven in a forward direction to receive crop stalks, said row unit comprising:a pair of rotatable side-by-side stalk rolls in a horizontal plane oriented longitudinally fore and aft relative to the forward direction and having a forward end;
a device for powering said stalk rolls in counter rotating directions;
wherein said stalk rolls each have a forward section with an annular base tapered towards the forward end of said stalk roll and at least one spiral auger flight on said annular base extending radially so that the outer diameter overlaps the outer diameter of an adjacent flight from a rearward end of said annular base significantly towards a forward most portion of said annular base; wherein the outer diameter of the auger flights are constant from the rearward end of said annular base to the forward end of said annular base; and
wherein said at least one auger flight has a leading edge at the forward end thereof, at least a portion of said leading edge adjacent the outer diameter of said at least one spiral auger flight extending perpendicularly relative to the rotational axis of said stalk roll to the outer diameter of said at least one auger flight.

US Pat. No. 10,334,782

GRASS COLLECTION CHUTE FASTENER

1. A grass collection chute fastener, comprising:a lever pivotably connected to a grass collection chute adjacent a first end of the lever; the lever having a main axis between the first end and a second end;
an elastic strap pivotably connected to the lever on a pivot axis offset from the main axis of the lever between the first end and the second end of the lever; and
a hook attached to the strap and insertable into a first hole adjacent a side discharge opening of a multi-blade mower deck to secure the grass collection chute over the side discharge opening by rotating the lever to tension the strap; and
a rod on the grass collection chute engaging the multi-blade mower deck by sliding the grass collection chute forward along a discharge opening guard below the side discharge opening.

US Pat. No. 10,334,781

SIDE SHAKE RATE BASED ON MACHINE THROUGHPUTS

CNH Industrial America LL...

1. An agricultural harvester, comprising:a chassis carrying a header for gathering a crop, said header removably attached to a feeder housing for feeding the crop into the agricultural harvester to be processed;
a threshing and separating system connected to said feeder housing for separating grain from Material Other than Grain (MOG);
a grain cleaning system connected to said threshing and separating system for further cleaning the separated grain;
said grain cleaning system having at least one sieve operable to oscillate fore and aft;
said grain cleaning system further having a side shaker mechanism operable to produce a side to side shaking motion in said at least one sieve; and
a control system connected to said side shaker mechanism and operable to automatically proportionately increase an amount of said side to side shaking motion as a function of an amount and type of crop being processed, wherein said automatic proportionate increase of said amount of said side to side shaking motion is one of linear and non-linear.

US Pat. No. 10,334,780

MOWER WITH FOLDING FRAME

EXCEL INDUSTRIES, INC., ...

1. A mower comprising:a principal frame including a rear frame portion having one pair of ground engaging drive wheels and a forward frame portion having a second pair of wheels, the rear frame portion and the forward frame portion being hinged together for folding about a transverse axis between a first, mowing position and a second, folded position,
a mower deck suitable for cutting grass, the mower deck adjustably connected to the forward frame portion by a pivot lever assembly that is movable for adjusting the height of the mower deck between a first low position for cutting grass at a first length and a second elevated position for cutting grass at a second length that is longer than the first length,
an actuator assembly operatively interconnecting between the rear frame portion and the forward frame portion, the actuator assembly being operable in two modes; (a) a first mode wherein the actuator assembly moves between a first actuator position and a second actuator position thereby causing the mower deck height to be adjusted between the first low position and the second elevated position; (b) and a second mode wherein the actuator assembly moves between a third actuator position and a fourth actuator position thereby causing the forward frame portion to fold with respect to the rear frame portion along said transverse axis between the first, mowing position and the second, folded position,
the actuator assembly being connected to the forward frame portion by a pivot bracket and the pivot bracket being selectively connectable to the forward frame portion in one of two connection modes, (a) a first pivoting connection mode wherein the pivot bracket is free to pivot with respect to the forward frame portion, and (b) a second fixed connection mode wherein the pivot bracket is fixed to the forward frame portion and is not free to pivot with respect to the forward frame portion,
such that when the pivot bracket is connected to the forward frame portion in the first pivoting connection mode, the pivot bracket is able to urge the pivot lever assembly between the first position and the second position when the actuator moves between the first actuator position and the second actuator position thereby causing the mower deck to move between the first low position and the second elevated position, and such that when the pivot bracket is connected to the forward frame portion in the second fixed connection mode, the actuator is able to move between the third actuator position to the fourth actuator position thereby causing the forward frame portion and the rear frame portion to fold and unfold with respect to each other.

US Pat. No. 10,334,779

BALANCED TRIM SHIELD WITH A SINGLE, DUAL DIRECTION LINE CUTTING MEMBER

HUSQVARNA AB, Huskvarna ...

1. A hand-held cutting device comprising:an elongated member graspable along a portion thereof by an operator;
a trimmer head disposed at one end of the elongated member and configured to be rotatable to perform a cutting function using trimmer line held at a portion of the trimmer head;
a power unit operably coupled to the trimmer head to selectively cause rotation of the trimmer head; and
a trim shield disposed to extend away from the elongated member to a position radially outward relative to the trimmer head proximate to at least a portion of a path traced by a distal end of the trimmer line when the trimmer head is rotated,
wherein the trim shield comprises:
a first housing portion disposed on one side of a longitudinal centerline of the device;
a second housing portion disposed on an opposite side of the longitudinal centerline and substantially symmetrical relative to the first housing portion;
a cutter mount disposed at the longitudinal centerline on an interior portion of the trim shield proximate to an intersection of the first housing portion and second housing portion, the cutter mount extending downward from an end of the trimmer shield that is configured to be operably coupled to the elongated member and comprising a first fixing member and a second fixing member; and
a cutting member operably coupled to the cutter mount with substantially equal portions of the cutting member extending to respective opposing sides of the longitudinal centerline, the cutting member comprising a single knife element, the single knife element comprising a first knife edge and a second knife edge,
wherein the cutting member is operably coupled to the cutter mount via the first and second fixing members, the cutting member extending downward from and parallel to the first and second fixing members.

US Pat. No. 10,334,778

QUICK LOADING TRIMMER HEAD

HUSQVARNA AB, Huskvarna ...

1. A hand-held cutting device comprising:an elongated member graspable along a portion thereof by an operator;
a trimmer head disposed at one end of the elongated member, the trimmer head configured to rotate to perform a cutting function using a trimmer line held by the trimmer head; and
a power unit operably coupled to the trimmer head to selectively cause rotation of the trimmer head via turning a shaft;
wherein the trimmer head comprises a line holding assembly comprising a spool and a core;
wherein the spool is configured to hold the trimmer line and the spool is operably coupled to the core;
wherein the core is comprised of a first core portion and a second core portion;
wherein the second core portion is non-rotatably engaged with the first core portion when the trimmer head is in an at-rest state, and the second core portion is rotatable relative to the first core portion when the trimmer head is in an in-use state and rotating;
wherein the first core portion comprises a locking projection operably coupled to a spring that applies a bias force on the locking projection in a direction away from an axis of rotation of the trimmer head;
wherein the locking projection engages with a lock recess of the second core portion when the trimmer head is in the at-rest state;
wherein the first core portion further comprises a counterweight operably coupled to the locking projection; and
wherein, in response to rotation of the trimmer head, the counterweight moves radially outwards and away from the axis of rotation of the trimmer head causing the locking projection to move radially inwards towards the axis of rotation of the trimmer head, against the bias force, and out of engagement with the lock recess.

US Pat. No. 10,334,777

ELECTRIC WORK VEHICLE

Kubota Corporation, Osak...

1. An electric work vehicle comprising:a vehicle body;
a carrier provided separately from the vehicle body for mounting/dismounting a battery, the carrier having wheels for movement thereof;
a carrier storage section provided in the vehicle body for attaching the carrier to the vehicle body;
an attachment mechanism for attaching/detaching the carrier to/from the carrier storage section; and
a fixing mechanism for releasably connecting the carrier to the carrier storage section, the fixing mechanism comprising:
a handle portion on the carrier, the handle portion movable between a lowered position and an elevated position; and
an engaging portion on the attachment mechanism,
wherein:
in response to movement of the handle portion to the lowered position when the carrier is attached to the carrier storage section, the handle portion engages the engaging portion to fix the carrier to the carrier storage section, and
in response to movement of the handle portion to the elevated position when the carrier is attached to the carrier storage section, the handle portion disengages the engaging portion to release the carrier to the carrier storage section.

US Pat. No. 10,334,776

METHOD AND SYSTEM HAVING AN INTERMEDIATE HOLDING VESSEL FOR COMBINING CHEMICAL INJECTION SUBSTANCES FOR A SPRAY SYSTEM

AGCO Corporation, Duluth...

1. An agricultural spraying system for use in applying at least one substance to a field, the agricultural spraying system comprising:a main tank containing water;
a plurality of vessels, each containing a substance;
a mixed solution tank containing a mixed solution formed from water from the main tank and a substance from at least one of the plurality of vessels;
a first conduit fluidly connecting the main tank, the plurality of vessels, and the mixed solution tank;
a transfer pump that provides motive force for the water through the first conduit;
an injector associated with each of the vessels, for release of the substance in that vessel into the first conduit;
a mixer positioned along the first conduit between the plurality of vessels and the mixed solution tank configured to mix the water from the main tank and the substance from the at least one of the plurality of vessels prior to reaching the mixed solution tank;
a valve that prevents any of the substances and the mixed solution from entering the main tank;
a boom manifold having an inlet and an outlet with a plurality of applicator spray nozzles positioned between the inlet and outlet that are configured to dispense the mixed solution;
a second conduit fluidly connecting the mixed solution tank and the inlet of the boom manifold;
a spray pump located in the second conduit that provides motive force for the mixed solution through the second conduit, wherein the transfer pump has a greater flow capacity than a flow capacity of the spray pump; and
a third conduit fluidly connecting the outlet of the boom manifold and the mixed solution tank, wherein mixed solution supplied through the second conduit by the spray pump that is not dispensed by the applicator spray nozzles is returned to the mixed solution tank through the third conduit.

US Pat. No. 10,334,775

PARTICULATE SOLID METERING AND MIXING SYSTEM FOR ROTARY SEED BROADCASTER USED FOR SOWING IN AGRICULTURAL MACHINES

Jose Roberto do Amaral As...

1. A metering and mixing system of solid particulates for a seed meter in an agricultural equipment for sowing, the metering and mixing system of solid particulates comprising:a seed feeder;
a seed meter comprising a rotary disc with holes;
a feed receiver mounted under the seed feeder and comprising:
a mixing compartment;
a feeder of solid particulates in fluid communication with the mixing compartment, the mixing compartment comprising a propeller for mixing together the seeds and the solid particulates received simultaneously in the mixing compartment to provide treated seeds to the seed meter; and
an outlet window that leads the treated seeds to the seed meter,
wherein the mixing compartment including the propeller is positioned between the seed feeder and the seed meter.

US Pat. No. 10,334,774

ADJUSTABLE CLAMP ON HEAD BRACKET

CNH Industrial Canada, Lt...

1. A towable agricultural implement, comprising:a tool bar;
an elongated C-shaped channel member coupled to the tool bar, the C-shaped channel member having a closed side and an open side and defining an inner edge along its open side;
a row unit supported relative to the tool bar via a head bracket; and
a clamping assembly configured to fasten the head bracket to the C-shaped channel member, the clamping assembly comprising a clamping nut and a clamping bolt, the clamping nut including a rigid member defining a threaded aperture configured to receive the clamping bolt, the clamping nut further comprising an elongated lip extending from the rigid member and configured to engage the inner edge of the C-shaped channel member as the clamping bolt is tightened relative to the clamping nut.

US Pat. No. 10,334,771

WHEEL POSITION CONTROL SYSTEM FOR AN AGRICULTURAL IMPLEMENT

CNH Industrial America LL...

1. An agricultural implement system, comprising:a toolbar assembly configured to support a plurality of row units;
a plurality of wheels configured to support the toolbar assembly above a soil surface, wherein the plurality of wheels comprises a first wheel and a second wheel, and at least one row unit of the plurality of row units is configured to be disposed between the first wheel and the second wheel;
a wheel position control system configured to control movement of each wheel of the plurality of wheels relative to the toolbar assembly, wherein the wheel position control system is configured to instruct a first actuator and a second actuator to lower the first wheel and the second wheel, respectively, relative to the toolbar assembly to transition the agricultural implement system to a non-working position, in which the first and second wheels engage the soil surface and the plurality of row units is disengaged from the soil surface, the wheel position control system is configured to instruct the first actuator and the second actuator to raise the first wheel and the second wheel, respectively, relative to the toolbar assembly to transition the agricultural implement system to a working position, in which the first wheel engages the soil surface and the plurality of row units engages the soil surface, and the wheel position control system is configured to instruct the second actuator to raise the second wheel above the first wheel relative to the toolbar assembly while the agricultural implement system is in the working position such that the second wheel is disengaged from the soil surface,
wherein the wheel position control system is configured to selectively instruct the second actuator to lower the second wheel into engagement with the soil surface while the agricultural implement system is in the working position and a soil softness exceeds a soil softness threshold value, and
a load sensor configured to output a signal indicative of a load on the first wheel, wherein the wheel position control system is configured to determine the soil softness based on the signal.
US Pat. No. 10,334,854

HERBICIDE COMBINATIONS COMPRISING GLUFOSINATE AND INDAZIFLAM

BAYER CROPSCIENCE AKTIENG...

1. An herbicidal composition comprising(i) glufosinate and/or an agronomically acceptable salt thereof,
and
(ii) indaziflam,
wherein the ratio by weight of the total amount of component (i) to the total amount of component (ii) is in a range of from 25:1 to 50:1 based on the total amount of the composition;
wherein components (i) and (ii) are the only agriculturally active components wherein the components (i) and (ii) together provide better herbicidal activity than (i) or (ii) alone.
US Pat. No. 10,335,366

RISPERIDONE OR PALIPERIDONE IMPLANT FORMULATION

1. An injectable composition consisting ofabout 13% wt of drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination; and
a polymeric solution consisting of DMSO and biocompatible poly(lactide-co-glycolide) (PLGA) copolymer having a monomer ratio of lactic acid to glycolic acid of about 50:50 and an inherent viscosity in the range of 0.25-0.30 dl/g measured by gel permeation chromatography in tetrahydrofuran at 30° C. using a flow rate of 1 ml/min; wherein
the mass ratio of polymeric solution to drug is about 6.5:1 to about 7:1; and
the mass ratio of DMSO to drug is about 4:1 to about 5:1.
US Pat. No. 10,335,623

NON-FLAMMABLE COMPOSITIONS OF CHLORO-TRIFLUOROPROPENE

Arkema Inc., King of Pru...

1. A non-flammable composition comprising (1) greater than 99 wt % 1-chloro-3,3,3-trifluoropropene and (2) from between about 0.02 to 0.7 wt % of 1,3,3,3-tetrafluoropropene and (3) from between about 0.00004 to 0. 0002 wt % 3,3,3-trifluoropropene and (4) from about 0.01 to 0.2 wt % 1,1,1,3,3-pentafluoropropane wherein said composition is non-flammable at at least one temperature between about 60° C. to about 100° C. when tested in accordance with ASTM 681-09.
US Pat. No. 10,336,648

SLIP COMPOSITION

1. A slip composition including ferromagnetic material having a mean particle size of not more than about 6 microns, a glass frit having a mean particle size of not more than 6 microns, and a methanol vehicle.
US Pat. No. 10,336,904

COMPOSITION OF A BLEND OF POLYAMIDE AND POLYESTER RESINS

RHODIA OPERATIONS, Auber...

1. A resin blend composition of a polyamide resin and of a polyester resin, the composition comprising:a) from 1 wt. % to 98 wt. % of a thermoplastic polyamide resin;
b) from 1 wt. % to 98 wt. % of a thermoplastic polyester resin comprising a homopolymer or a copolymer that is obtained by condensation of a dicarboxylic acid or its derivatives that can form an ester, with a diol or its derivatives that can form an ester, or a mixture thereof, wherein the thermoplastic polyester resin comprises at least one C2-C20 aliphatic glycol as the diol monomer;
c) from 0.01 wt. % to 10 wt. % of an epoxy resin having an epoxy equivalent weight (EEW) ranging from 2100 g/eq and 6000 g/eq; and
d) from 1 wt. % to 40 wt. % of a red phosphorus fireproofing agent,wherein the weight percentages are based on the total weight of the composition.
US Pat. No. 10,340,492

ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENE STRETCHED POROUS FILM

TOSOH CORPORATION, Shuna...

1. An ultrahigh molecular weight polyethylene stretched microporous film, which comprises at least an ultrahigh molecular weight polyethylene having an intrinsic viscosity ([?]) of at least 7 dl/g and at most 60 dl/g, and which has a porosity of at least 10% and at most 70% and a breaking stress of at least 1 MPa when melt-stretched at 150° C.
US Pat. No. 10,334,855

MODIFIED BIOLOGICAL CONTROL AGENTS AND THEIR USES

AGBIOME, INC., Research ...

1. A composition comprising (1) a a dried biological control agent and (2) a fungicide, a pesticide, an insecticide, or a herbicide, wherein said dried biological control agent is deposited as NRRL No. B-50897 and is a viable Pseudomonas chlororaphis strain, wherein said dried biological control agent and said fungicide, pesticide, insecticide, or herbicide are provided in an amount effective to control a plant pathogen.
US Pat. No. 10,336,649

CERAMIC COMPOSITION FOR COATING METALLIC SURFACES, METHOD AND RESULTING CERAMIC LAYER

TORRECID, S.A., Alcora (...

1. A ceramic composition for the coating of metallic surfaces by means of thermal treatment that comprises:a. at least one frit whose percentage by weight is between 40% and 82%,
b. at least one refractory compound with a melting point higher than 1600° C., and
c. at least one synthetic compound comprising one or more elements selected from the group consisting of Co, Ni, Cu, Fe, Mo, Mn Cr, and a combination thereof;
wherein the composition by weight of the at least one frit comprises SiO2 between 55% and 70% by weight, R2O between 7% and 20% by weight, RO between 0% and 15% by weight, MOx between 0% and 8% by weight, MO2 between 0% and 7% by weight, Al2O3 0.5% and 8% by weight, and B2O3 between 3% and 10% by weight; where R2O represents at least one oxide selected from the group consisting of Li2O, Na2O, K2O and a combination thereof, where RO represents at least one oxide selected from the group consisting of ZnO, MgO, CaO, BaO and a combination thereof, where MOx represents at least one oxide selected from the group consisting of CuO, MnO2, Fe2O3, MoO3, CoO, NiO and a combination thereof, and where MO2 represents at least one oxide selected from the group consisting of TiO, CeO2 and a combination thereof.
US Pat. No. 10,335,368

ULTRASOUND-TRIGGERABLE AGENTS FOR TISSUE ENGINEERING

THE REGENTS OF THE UNIVER...

1. A method of delivering an effective amount of a therapeutic agent to an individual in need thereof comprising administering to the individual a device comprising:(a) a hydrogel scaffold having a density of polymer within the hydrogel scaffold of about 1 mg/mL to about 50 mg/mL; and
(b) an emulsion comprising a first population of perfluorocarbon (PFC) droplets comprising a first therapeutic agent in the interior thereof, said first population of PFC droplets being within the hydrogel scaffold and having the property of vaporizing at a first ultrasound frequency and/or acoustic pressure threshold; the device further comprising
a second population of PFC droplets comprising a second therapeutic agent in the interior thereof, said second population of PFC droplets being within the hydrogel scaffold and having the property of vaporizing at a second ultrasound frequency and/or acoustic pressure threshold that is different than the first ultrasound frequency and/or acoustic pressure threshold, and
exposing the hydrogel scaffold to the first ultrasound frequency and/or acoustic pressure threshold to deliver the first therapeutic agent,
wherein the concentration of the first population of PFC droplets is sufficient to result in acoustic shadowing upon exposure of the first population of PFC droplets to ultrasound.
US Pat. No. 10,335,625

PHOSPHATE FIRE-EXTINGUISHING COMPOSITION

1. A phosphate fire extinguishing composition, wherein the fire extinguishing composition contains a phosphate compound, a flame-retardant extinguishing component, which enhances a fire extinguishing effect of the fire extinguishing composition and an additive, andthe components and their contents in the fire extinguishing composition include:
phosphate compound 30%˜95%,
flame-retardant extinguishing component 5%˜60%, and
additive 1%˜10%,
the phosphate compound is ferric phosphate; and
the phosphate fire extinguishing composition is spheres, sheets, strips, blocks or honeycombs.
US Pat. No. 10,336,138

RUBBER COMPOSITION AND METHOD FOR PRODUCING SAME, CROSSLINKED RUBBER COMPOSITION, AND TIRE

BRIDGESTONE CORPORATION, ...

1. A rubber composition containing a zinc oxide and a carbon black having a surface average acidic functional group amount (?eq/m2) of 0.15 or more and less than 3.00, wherein:the zinc oxide comprises both a zinc oxide having an average primary particle size of 10 to 200 nm and zinc oxide having an average primary particle size of 200 to 800 nm, and
a total volume of aggregates of the zinc oxide with a diameter of 20 ?m or more is 0.008 or less in the rubber composition by volume fraction.
US Pat. No. 10,334,857

CHROMOBACTERIUM SPECIES WITH INSECTICIDAL ACTIVITY

The United States of Amer...

1. A method of killing insect larvae comprising applying a biocontrol agent in an amount effective to kill said insect larvae, wherein said biocontrol agent comprises a carrier and an insecticidal composition selected from the group consisting of isolated Chromobacterium phragmitis strain 113-1 deposited with the accession number NRRL B-67133, culture media in which said C. phragmitis strain grew, and a combination thereof, wherein said biocontrol agent is applied to an area in which said insect larvae are present or onto an object in said area and wherein said insecticidal composition comprised in the biocontrol agent kills said insect larvae after said insect larvae ingests said insecticidal composition.
US Pat. No. 10,335,369

COMPOSITIONS COMPRISING A DELIVERY AGENT AND PREPARATION THEREOF

1. A process of producing by dry granulation a granule comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant, wherein said process comprises the steps:a) mixing said salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and said lubricant for more than 5 minutes; and
b) optionally roller compacting the mixture of step a, wherein the granule produced by said process does not contain a pharmaceutically active agent.
US Pat. No. 10,336,907

CRUMB RUBBER MODIFIED BITUMEN AND PROCESS OF PRODUCTION THEREOF

Indian Oil Corporation Li...

1. A crumb rubber modified bitumen composition comprising:(a) Asphalt in the range of 50 to 90% by weight of the composition;
(b) crumb rubber in the range of 5 to 30% by weight of the composition;
(c) PET derivatives in the range of 0.1 to 10% by weight of the composition; and
(d) bi-functional reactive compounds in the range of 0.1 to 10% by weight of the total composition;
wherein, Asphalt is having penetration in the range of 30 to 150 dmm;
wherein the bi-functional reactive compounds are selected from pimelic acid, suberic acid, azelaic acid, sebacic acid and dodecanedioic acid.
US Pat. No. 10,334,858

COMPOSITIONS AND METHODS FOR THE IMPROVED PRODUCTION AND DELIVERY OF RNA BY EFFICIENT TRANSCRIPTION TERMINATION

1. A transcriptional terminator sequence comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 13, 18, and 21-23.
US Pat. No. 10,335,370

CONTROLLED RELEASE COMPOSITION

1. A controlled release implantable pharmaceutical composition comprising a plurality of microparticles distributed or embedded in a matrix, wherein:the plurality of microparticles comprises poly(L-lactide acid) and a first active agent;
the matrix comprises poly(lactide-co-glycolide acid);
the plurality of microparticles have a diameter ranging from about 120 ?m to about 1000 ?m; and
wherein the controlled release implantable pharmaceutical composition is manufactured by a method comprising the steps of:
preparing the plurality of microparticles;
applying the plurality of microparticles to a matrix-forming composition comprising poly(lactide-co-glycolide acid) to form a mixture;
heating the matrix-forming composition to a temperature Tm wherein 76° C. cooling down to form the controlled release implantable pharmaceutical composition.
US Pat. No. 10,336,652

ENHANCING CALCINED CLAY USE WITH INORGANIC BINDERS

GCP Applied Technologies ...

1. A cementitious composition, comprising:a hydratable cement, limestone, or mixture thereof in the amount of 95 to 30% by weight based on the total dry weight of the composition;
a calcined clay comprising Fe2O3 in an amount of 1% to 15% by weight of the calcined clay, the calcined clay being present in the amount of 5% to 70% based on the total dry weight of the cementitious composition; and
at least one tertiary alkanolamine comprising diethanolisopropanolamine (DEIPA) in the amount of 0.002% to 0.2% by weight based on the total dry weight of the cementitious composition.
US Pat. No. 10,334,859

METHOD AND PESTICIDAL MIXTURES FOR CONTROLLING PENTATOMIDAE PESTS

BASF SE, Ludwigshafen am...

1. A pesticidal mixture comprising as active compounds1) at least one compound (I), which is a component of the ginkgo tree selected from the group consisting of bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and ginkgolide M,
and
2) alpha-cypermethrin;
in a synergistically effective amount, wherein the weight ratio of compound I and alpha-cypermethrin is from 5000:1 to 1:5.
US Pat. No. 10,335,371

SOLID PHARMACEUTICAL DOSAGE FORM SUITABLE FOR USE AS DRINKING WATER MEDICATION

Universiteit Gent, (BE) ...

1. A method for the preparation of a spray-dried solid pharmaceutical multiparticulate dosage form, the method comprising:preparing a suspension comprising a pharmaceutical non-solubilized active ingredient, a non-ionic surfactant having an Hydrophilic Lipophilic Balance (HLB) of at least 8 and water;
milling the suspension;
adding a maltodextrin to the milled suspension; and
spray-drying the milled suspension.
US Pat. No. 10,335,373

TAMPER RESISTANT AND DOSE-DUMPING RESISTANT PHARMACEUTICAL DOSAGE FORM

GRUNENTHAL GMBH, Aachen ...

18. A process for the production of a tamper-resistant pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a prolonged release matrix, which comprises a prolonged release matrix material selected from the group consisting of nonionic acrylic polymers and which provides prolonged release of the pharmacologically active ingredient, wherein the prolonged release matrix material is employed in the form of an aqueous dispersion, and the pharmaceutical dosage form not comprising either ethyl cellulose or an ionic acrylic polymer, andwherein:
(a) the pharmaceutical dosage form is monolithic, has a breaking strength of at least 300 N, and has an extension in any direction of at least 2.0 mm; or
(b) the pharmaceutical dosage form is oligoparticulate or multiparticulate, comprising a plurality of individual particulates, wherein at least a fraction of the individual particulates have a breaking strength of at least 300 N, and wherein individual particulates comprising the pharmacologically active ingredient have an extension in any direction of at least 2.0 mm;
said process comprising extruding a homogeneous mixture comprising the pharmacologically active ingredient and the prolonged release matrix material in the presence of water, and evaporating the water in the course of extrusion.
US Pat. No. 10,334,862

METHODS FOR PRESERVING PROCESSED MEATS

The Hillshire Brands Comp...

1. A method comprising:forming a first portion of meat by adding Propionibacterium to a meat substrate;
artificially inducing glycolysis in the meat substrate;
incubating the first portion of meat to achieve a first propionic concentration in excess of 1% wt.;
after the incubating, mixing the first portion of meat with a second portion of meat to form a third portion of meat, wherein the third portion of meat has a third propionic acid concentration of 0.1%-1% wt., inclusive.
US Pat. No. 10,336,912

METHODS FOR PRODUCING AND USING AQUEOUS POLYURETHANE/POLYACRYLATE HYBRID DISPERSIONS AND USE OF SAID AQUEOUS POLYURETHANE/POLYACRYLATE HYBRID DISPERSIONS IN COATING AGENTS

BASF SE, Ludwigshafen (D...

1. An aqueous polyurethane-polyacrylate hybrid dispersion obtained by radical polymerization of an acrylate polymer (A1) in the presence of at least one polyurethane (P1) and at least one initiator system,wherein the at least one polyurethane (P1) has a content of polyalkylene oxide of at least 10 g/kg of polyurethane and a content of a sulfonated material of at least 25 mmol per kg of polyurethane and the acrylate polymer (A1) has a glass transition temperature of from ?50° C. to 50° C. and the mass fraction of the polyurethane is at least 5% and no more than 95% based on the total weight of the polyurethane-polyacrylate hybrid,
wherein the acrylate polymer (A1) comprises
(a) at least two monomers M1 having a glass transition temperature of ?25° C., and
(b) at least two monomers M2 having a glass transition temperature of ?25° C., and
(c) optionally a monomer M3,
wherein the polyurethane-polyacrylate hybrid dispersions comprise long-chain alkanol-based polyethylene oxides and sodium salts of 2-aminoethyl-2-aminoethanesulfonic acid.
US Pat. No. 10,335,375

ANTI-OVERINGESTION ABUSE DETERRENT COMPOSITIONS

Patheon Softgels, Inc., ...

1. An oral pharmaceutical composition comprising:(a) about 50% to about 70% by mass of glyceryl monolinoleate;
(b) about 2% to 50% by mass ion exchanger;
(c) about 25% to about 40% by mass of a polyethylene oxide having a molecular weight (Mv) of about 1,000,000 to about 7,000,000; and
(d) about 1% to 20% by mass of one or more active pharmaceutical ingredients (API), wherein 15% or about 30% of the API is in a free form and 70% or about 85% of the API is bound to the ion exchanger.
US Pat. No. 10,336,657

COMPOSITIONS AND METHODS FOR CURING CONCRETE

Advanced Concrete Technol...

1. A method for curing concrete, comprising:applying a composition including at least one hardening and densifying agent blended with a temporary moisture sealing agent to a surface of fresh concrete, the at least one hardening and densifying agent entering pores in the surface of the fresh concrete, the temporary moisture sealing agent remaining substantially on the surface of the fresh concrete;
curing the fresh concrete with the temporary moisture sealing agent on the surface and holding water within the fresh concrete; and
reacting one or more materials of the at least one hardening and densifying agent with free lime at or near the surface of the fresh concrete to provide a hardened and densified surface,
the temporary moisture sealing agent capable of breaking down and self-dissipating to facilitate its compete removal from the surface of the fresh concrete less than a month after its application as a film to the surface of the fresh concrete to expose the hardened and densified surface.
US Pat. No. 10,336,913

CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE

DOW CORNING TORAY CO., LT...

1. A curable silicone composition comprising:(A) a diorganopolysiloxane having at least two alkenyl groups in a molecule and containing siloxane units represented by the formula: R12SiO2/2 wherein each R1 independently represents an aryl group;
(B) at least two types of resinous organopolysiloxanes having different mass average molecular weights based on standard polystyrene conversion gel permeation chromatography, and each comprising siloxane units represented by the formula: SiO4/2, siloxane units represented by the formula: R22R3SiO1/2 wherein each R2 independently represents a monovalent hydrocarbon group lacking aliphatic unsaturated bonds and each R3 independently represents an alkenyl group, and siloxane units represented by the formula: R23SiO1/2 wherein R2 is as defined above, in an amount of 10 to 100 parts by mass per 100 parts by mass of component (A);
(C) an organopolysiloxane having at least two silicon-bonded hydrogen atoms in a molecule, in an amount so that the amount of silicon-bonded hydrogen atoms in component (C) is from 0.1 to 10 mol per 1 mol of total alkenyl groups in components (A) and (B); and
(D) a catalytic amount of hydrosilylation reaction catalyst.
US Pat. No. 10,335,376

RALOXIFENE SPRINKLE COMPOSITION

Sun Pharmaceutical Indust...

1. A sprinkle capsule composition comprising a plurality of particulates, wherein each particulate comprises:a) a core comprising raloxifene; and
b) a taste-masking coating over the core to form coated cores having a D90 particle size of less than or equal to 900 ?m;
wherein, the particulates are stable when sprinkled on a soft food and wherein raloxifene is present in an amount from about 10% to about 80% based on the total weight of the composition.
US Pat. No. 10,335,377

OVER-PATCH HAVING IMPROVED COMPATIBILITY AND A LONG ADHESION DURATION AND METHOD FOR PRODUCING SAID OVER-PATCH

LTS Lohmann Therapie-Syst...

1. A medical product comprising (1) a central compartment and (2) an active-ingredient-free overplaster,wherein said medical product is a diagnostic agent, and
wherein said overplaster comprises
a) a water vapor-permeable backing layer and
b) a pressure-sensitive, acting-ingredient-free polymer layer, and
wherein said central compartment comprises a diagnostic apparatus and is pressure-sensitively adhered to a releasable release liner such that said central compartment can be applied directly to the skin after removal of said releasable release liner,
said overplaster fixes the central compartment and overhangs said central compartment on all sides and the active-ingredient-free polymer layer comprises non-amine-resistant, highly water vapor-permeable polysiloxanes, polyacrylates or vinyl acetate-acrylate copolymers without free acid groups or with an acid number of less than 1, styrene-isoprene-styrene block copolymers present in combination with at least one of hydrogenated hydrocarbon resins and oils, or styrene-butadiene-styrene block copolymers present in combination with at least one of hydrogenated hydrocarbon resins and oils.
US Pat. No. 10,336,659

QUICK DRYING POLYMERIC COATING

VERDESIAN LIFE SCIENCES, ...

1. A fertilizer product comprising a quantity of a solid fertilizer having a coating composition applied to a surface thereof, wherein said coating composition comprises an aqueous dispersion, wherein said aqueous dispersion comprises about 20-50% by weight of a polycarboxylated polymer and about 0.5-5% by weight of boric acid.
US Pat. No. 10,336,915

ANAEROBICALLY CURABLE COMPOSITIONS

1. An anaerobically curable composition comprising:(a) a (meth)acrylate component;
(b) a cure inducing component; and
(c) at least one stabilizer comprising:at least one C6-C50 aliphatic chain, derived from a fatty acid, said stabilizer further comprising at least 2 nitrogen atoms and at least 4 carboxy groups.
US Pat. No. 10,335,378

INHIBITION OF CENTRAL NERVOUS SYSTEM EFFECTS FROM SMOKING AND SENSORY EFFECTS FROM SMOKING

Altria Client Services LL...

1. A smoking cessation treatment, comprising administering to the trachea and/or buccal mucosa of a human subject an effective amount of a product comprising an effective amount of an active ingredient consisting of at least one compound selected from the group consisting of bornyl acetate, isobornyl acetate, mono-bornyl succinate, mono-isobornyl succinate, mono-bornyl formate, and mono-isobornyl formate; wherein the product is free of nicotine, caffeine, and menthyl valerate, wherein the human is a smoker, and wherein the active ingredient is present in an amount from about 9 milligrams to about 24 milligrams.
US Pat. No. 10,340,504

METAL AIR BATTERY

Mahle International GmbH,...

1. A metal-air battery comprising:a housing;
at least one hollow-cylindrical cathode arranged in the housing between an air chamber and an electrolyte chamber;
at least one metallic anode arranged in the electrolyte chamber;
an air path leading through the housing from an air inlet of the housing, which is fluidically connected to the air chamber, to an air outlet of the housing, which is fluidically connected to the air chamber;
an air supply device for generating an air flow following the air path impinging on the at least one hollow-cylindrical cathode;
an electrolyte path leading through the housing from an electrolyte inlet of the housing, which is fluidically connected to the electrolyte chamber, to an electrolyte outlet of the housing, which is fluidically connected to the electrolyte chamber; and
an electrolyte supply device for generating an electrolyte flow following the electrolyte path impinging on the at least one metallic anode and the at least one hollow-cylindrical cathode.
US Pat. No. 10,336,918

ADHESIVE COMPOSITION

ZEON CORPORATION, Tokyo ...

1. An adhesive composition containing:a latex consisting essentially of: (i) a highly saturated nitrile rubber (A) which has ?,?-ethylenically unsaturated nitrile monomer units 10 to 55 wt %, conjugated diene monomer units 25 to 89 wt %, ?,?-ethylenically unsaturated dicarboxylic acid monoester monomer units 1 to 20 wt %, and the highly saturated nitrile rubber (A) has an iodine value of 120 or less, and (ii) water; and
polyethyleneimine, wherein:
a solid content in the latex is 5 to 60 wt %, and
a content of the polyethyleneimine is 0.1 to 40 parts by weight with respect to 100 parts by weight of the highly saturated nitrile rubber (A).
US Pat. No. 10,334,869

METHOD FOR INCREASING CONCENTRATION OF AVENANTHRAMIDES IN OATS

HER MAJESTY THE QUEEN IN ...

1. A method of increasing avenanthramide content in oat seeds, the method comprising:(a) dry-heating the oat seeds at a temperature of 30 to 40° C. for 48 to 72 hours then at a temperature of about 70° C. for 144 to 168 hours to produce oat seeds in a state of secondary dormancy; and
(b) steeping the oat seeds from step (a) at a temperature from 4 to 40° C. for from 96 to 120 hours resulting in a false malting of the oat seeds,
wherein the false malting increases the avenanthramide concentration, without germination of the oat seeds.
US Pat. No. 10,335,381

STABILIZED FORMULATION OF TRIAMCINOLONE ACETONIDE

University of Mississippi...

1. A storage stable therapeutic composition for topical administration comprising:about 0.01 to 0.3% by weight triamcinolone acetonide;
about 0.25 to about 6% by weight lidocaine hydrochloride;
a base, the base comprising a water soluble salt of a copolymer of a lower alkyl vinyl ether and maleic acid or anhydride and a polyalkylene glycol;
wherein the composition is free from butylated hydroxytoluene and free from butylated hydroxyanisole.
US Pat. No. 10,336,663

METHODS FOR THE PREPARATION AND USE OF SUSPENSIONS OF CHEMICALLY-TREATED SOLID OXIDES IN AN OLEFIN-DERIVED LIQUID MEDIUM

Chevron Phillips Chemical...

1. A process comprising:(a) contacting a first olefin feedstock comprising a first C4-C20 alpha-olefin with a first catalyst system in a first reaction zone to form a first oligomer product;
(b) discharging a first reaction zone effluent comprising the first oligomer product from the first reaction zone;
(c) (i) isolating an effluent fraction by removing at least a portion of the first catalyst system from the first reaction zone effluent, or (ii) deactivating the first catalyst system to form a deactivated first catalyst system, and isolating an effluent fraction by removing at least a portion of the deactivated first catalyst system from the first reaction zone effluent;
(d) isolating the first oligomer product by removing at least a portion of unreacted first C4-C20 alpha-olefin from the effluent fraction;
(e) contacting a suspension of a second chemically-treated solid oxide in a liquid medium, a second metallocene compound, a second organoaluminum compound, and a second olefin feedstock comprising a second C4-C20 alpha-olefin, in a second reaction zone to form a second oligomer product, wherein the liquid medium comprises at least a portion of the effluent fraction and/or at least a portion of the first oligomer product;
(f) discharging a second reaction zone effluent comprising the second oligomer product from the second reaction zone, the second oligomer product comprising a light fraction comprising C26 and lower oligomers, and a heavy oligomer product comprising C28 and higher oligomers;
(g) isolating the heavy oligomer product from the second oligomer product; and
(h) hydrogenating at least a portion of the heavy oligomer product to produce a hydrogenated heavy oligomer product.
US Pat. No. 10,334,870

PROCESSING OF WHOLE FRUITS AND VEGETABLES, PROCESSING OF SIDE-STREAM INGREDIENTS OF FRUITS AND VEGETABLES, AND USE OF THE PROCESSED FRUITS AND VEGETABLES IN BEVERAGE AND FOOD PRODUCTS

TROPICANA PRODUCTS, INC.,...

1. A method of processing pomace comprisingobtaining a pomace press cake by extracting juice from a fruit, vegetable, or combinations thereof;
hydrating the pomace press cake;
acidifying the pomace press cake with an organic acid;
micro-grinding the hydrated, acidified pomace press cake to reduce the particle size of the pomace to less than 250 microns.
US Pat. No. 10,336,920

FOAMABLE HOT MELT ADHESIVE COMPOSITIONS AND USE THEREOF

1. A foamed adhesive comprising about 20 to about 80 V/V % of foamed gas or air and 80 to about 20 V/V % of an adhesive composition prepared with(a) a hot melt adhesive comprising a polymer selected from the group consisting of ethylene-acrylate, polyolefin, and mixtures thereof, and optionally a wax, a tackifier, a plasticizer, and an additive;
(b) from about [3] to about 10 wt % of an olefin block copolymer having a melt index of equal to or greater than 5 g/10 min measured in accordance with ASTM D1238 at 190° C. and a DSC melting point greater than 100° C.; and
(c) optionally, from about 0.05 to about 10 wt % of a foam cell promoter;
wherein the ratio of the polymer in the hot melt adhesive to the olefin block copolymer is in the range of about 20:1 to about 2:1.
US Pat. No. 10,336,665

YIELDS IN XYLENE ISOMERIZATION USING LAYER MFI ZEOLITES

UOP LLC, Des Plaines, IL...


US Pat. No. 10,335,384

COMPOSITIONS COMPRISING MAGNOLIA, PHELLODENDRON, THEANINE AND/OR WHEY PROTEIN

NUTRAMAX LABORATORIES, IN...

1. An anxiolytic composition, comprising a combination of L-theanine, a whey protein, an extract of magnolia, and an extract of phellodendron provided in amounts synergistically effective to modulate one or more neurotransmitters.
US Pat. No. 10,336,922

COMPOSITIONS CONTAINING ETHYLENE POLYMERS

Kraton Chemical, LLC, Ja...

1. A composition comprising,(a) a polymer derived from ethylene polymer derived from at least one polar monomer with one or more ester groups, which polymerize with ethylene, and
(b) a rosin ester having a hydroxyl number and an acid number,
wherein the sum of the hydroxyl number and the acid number of the rosin ester is eighteen or less;
wherein the rosin ester has a PAN number of eight or less, an acid number of ten or less, and a weight average molecular weight from 800 g/mol to 2000 g/mol.
US Pat. No. 10,335,385

COMPOSITION CONTAINING NON-POLAR COMPOUNDS

Virun, Inc., Pomona, CA ...

1. A liquid emulsion concentrate composition, comprising:an emulsion stabilizer that is a fatty acid-modified carbohydrate-based macromolecule in an amount between more than 1% and up to 5%, by weight, of the concentrate composition;
a surfactant that is a PEG-derivative of Vitamin E, wherein the surfactant is present in an amount between 3% and 16%, by weight, of the concentrate composition;
a polar solvent in an amount between 40% and 60%, by weight, of the concentrate composition; and
one or more non-polar compounds that comprise non-polar active ingredients selected from among polyunsaturated fatty acids, omega-3 fatty acids, omega-6 fatty acids, omega-9 fatty acids, conjugated fatty acids, coenzyme Q-containing active ingredients, alpha lipoic acid, carotenoid-containing active ingredients and phytochemicals, wherein the one or more non-polar compounds is/are present in a total amount between 35% and 50%, inclusive, by weight, of the concentrate composition.
US Pat. No. 10,336,924

PRESSURE SENSITIVE ADHESIVE COMPOSITION AND PRESSURE SENSITIVE ADHESIVE PATTERN FORMED THERFROM

Dongwoo Fine-Chem Co., Lt...

8. An pressure sensitive adhesive pattern comprising a cured product of the pressure sensitive adhesive composition according to claim 1 and having a Tg of 0° C. or less, wherein the pressure sensitive adhesive pattern is a photoresist pattern.
US Pat. No. 10,335,387

METHOD FOR TREATING INFECTIOUS DISEASES WITH ISOTHIOCYANATE FUNCTIONAL COMPOUNDS

The William M. Yarbrough ...

1. A method for treating an infectious disease, comprising the step of:administering an isothiocyanate functional surfactant to a patient having an infectious disease.
US Pat. No. 10,336,669

METHOD FOR PREPARING HEXAFLUOROBUTADIENE

ARKEMA FRANCE, Colombes ...

1. A process for the preparation of hexafluorobutadiene comprising the stages of:a) hydrodechlorination of hexachlorobutadiene in order to form a first stream comprising 1,2,3,4-tetrachlorobutadiene and optionally unreacted hexachlorobutadiene,
b) fluorination of said first stream comprising 1,2,3,4-tetrachlorobutadiene obtained in stage a) in order to form a second stream comprising 1,1,2,3,4,4-hexafluorobutane,
c) dehydrogenation of said second stream comprising 1,1,2,3,4,4-hexafluorobutane in order to form a third stream comprising hexafluorobutadiene.
US Pat. No. 10,338,463

MASK FOR PHOTOLITHOGRAPHY, METHOD OF MANUFACTURING THE SAME AND METHOD OF MANUFACTURING SUBSTRATE USING THE SAME

Samsung Display Co., Ltd....

1. A mask for photolithography comprising:a transparent substrate;
a light blocking material across the transparent substrate comprising a plurality of first openings and a plurality of second openings spaced apart from the first opening;
a phase shift pattern on the transparent substrate and configured to change a phase of light, wherein the phase shift pattern is located in the plurality of first openings and not located in the plurality of second openings;
a dielectric layer on the transparent substrate; and
a negative refractive-index meta material layer on the dielectric layer.
US Pat. No. 10,336,670

METHOD FOR PRODUCING HIGH-OCTANE COMPONENTS FROM OLEFINS FROM CATALYTIC CRACKING

1. A method for producing a high-octane component of motor fuels from olefin-containing gas mixtures characterized in that an olefin-containing mixture comprising C2-C4 alkanes and olefins is oxidized with nitrous oxide, followed by an isolation of a product mixture as the high-octane component.
US Pat. No. 10,336,926

OXAZOLINE-BASED ADHESIVE FORMULATIONS

Sanford, L.P., Atlanta, ...

11. A method of making an adhesive formulation, comprising:combining at least one oxazoline polymer and casein to form an adhesive formulation,
wherein the casein is in the form of a casein solution comprising casein in an amount from about 10 percent to about 40 percent, by weight of the solution, and
wherein the casein solution further comprises an organic amine and deionized water.
US Pat. No. 10,338,464

PHOTOMASK INCLUDING TRANSFER PATTERNS FOR REDUCING A THERMAL STRESS

SK HYNIX INC., Icheon (K...

1. A photomask comprising:a light transmission substrate;
a plurality of pattern regions disposed over the light transmission substrate, a shape of the plurality of pattern regions being transferred onto a wafer during an exposure process; and
a light blocking region surrounding the plurality of pattern regions,
wherein each of the plurality of pattern regions is a light transmitting region that exposes a portion of the light transmission substrate,
wherein the light blocking region includes first light blocking patterns that respectively surround the plurality of pattern regions to have closed loop shapes and second light blocking patterns that are disposed between adjacent first light blocking patterns, adjacent second light blocking patterns being spaced apart from each other by a first distance in a first direction, and
wherein the first light blocking patterns have a first thickness and the second light blocking patterns have a second thickness which is smaller than the first thickness.
US Pat. No. 10,338,465

PELLICLE FRAME AND PELLICLE

SHIN-ETSU CHEMICAL CO., L...

1. A pellicle frame comprising:a frame base, and
a polymer coating layer coating at least an inner circumferential surface of the frame base, the polymer coating layer comprising an outermost polymer layer on a side farthest away from the frame base and one or more inner polymer layers between the frame base and the outermost polymer layer,
wherein at least one of the one or more inner polymer layers contains particles, and the outmost polymer layer contains no particles or has a particle concentration lower than a highest particle concentration among the one or more inner polymer layers.
US Pat. No. 10,336,928

CORROSION INHIBITED COMPOSITIONS AND METHODS OF USING SAME

1. A corrosion-inhibited composition comprising:a major amount of a liquid component selected from the group consisting of water, at least one freezing point depressant and mixtures thereof;
a t-butyl benzoic acid component in an amount in a range of about 1000 to about 35000 mg per liter of the composition;
a mixture of dicarboxylic acids comprising adipic acid, azelaic acid, sebacic acid, seberic acid, pimelic acid, and undecanoic acid, wherein the azelaic acid is present in an amount in a range of about 500 to about 12,500 mg per liter of the composition; and
an aromatic triazole component in an amount in a range of about 100 to about 3500 mg per liter of the composition; and
free of a C8-C12 aliphatic monobasic acid;wherein the composition causes less change in durometer, tensile strength, elongation and/or volume in at least one polymeric component of a cooling system in which the composition is employed relative to a reference composition which includes the C8-C12 aliphatic monobasic acid 2-ethyl hexanoic acid.
US Pat. No. 10,335,391

STABILIZED OXYMETAZOLINE FORMULATIONS AND THEIR USES

ACLARIS THERAPEUTICS, INC...

1. A method of treating facial erythema associated with rosacea in a patient in need of such treatment, comprising topically administering once daily to the site of erythema on the face of the patient a pharmaceutical composition comprising 1.0% w/w oxymetazoline hydrochloride thereof as the sole active ingredient, wherein the patient experiences no rebound or worsening of facial erythema post-treatment.
US Pat. No. 10,336,673

PROCESS FOR CONVERTING METHANOL TO HYDROCARBONS SUITABLE FOR USE AS GASOLINE OR BLENDSTOCK

1. A process for production of a hydrocarbon product suitable for use as gasoline or as a blendstock, said process comprising:converting a feed stream comprising alcohols, ethers or mixtures thereof over a metal-containing zeolite based catalyst, active in dehydrogenation of hydrocarbons, in a conversion step thereby obtaining a conversion effluent,
separating said effluent to obtain an aqueous process condensate stream, a liquid hydrocarbon stream and a gaseous stream,
removing H2 from at least part of the effluent thereby obtaining at least one at least partially H2 depleted recycle stream, wherein removing H2 is via a selective membrane, a selective oxidation step and/or a step wherein a hydrogen scavenger is converted into methanol or water in the presence of H2 and a hydrogenation catalyst, and
recycling the at least one at least partially H2 depleted recycle stream to the conversion step.
US Pat. No. 10,336,929

METHOD OF PRODUCING HEAT CONDUCTIVE SHEET

DEXERIALS CORPORATION, T...

1. A method of producing a heat conductive sheet, the method comprising:dispersing a fibrous filler in a binder resin to prepare a heat conductive sheet-forming composition;
forming a molded block using the prepared heat conductive sheet-forming composition according to an extrusion molding method or a die molding method;
slicing the formed molded block into a sheet;
pressing a sliced surface of the obtained sheet to smooth the sliced surface; and
disposing the smooth sliced surface of the sheet between a heat generating body and a heat dissipator.
US Pat. No. 10,338,468

PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE RESIN LAMINATE, RESIN PATTERN PRODUCTION METHOD, CURED FILM, AND DISPLAY DEVICE

ASAHI KASEI KABUSHIKI KAI...

1. A photosensitive resin laminate comprising a support film, and a photosensitive resin layer including:(A) an alkali-soluble polymer;
(B) a compound having an ethylenic unsaturated double bond; and
(C) a photopolymerization initiator;
wherein the photosensitive resin layer is laminated on the support film,
the photosensitive resin laminate is to be used to form a protective film for a conductor component,
the thickness of the photosensitive resin layer is less than or equal to 20 ?m, and
a cured product of the photosensitive resin layer satisfies the following conditions (1) to (3):
(1) a crosslink density of 1,000 mol/m3 to 8,000 mol/m3;
(2) a Tan ? peak top value of 0.4 or greater; and
(3) a refractive index of 1.50 to 1.60 at a wavelength of 532 nm.
US Pat. No. 10,336,932

MICRO-NANO COMPOSITE PLUGGING AGENT FOR DRILLING FLUID AND PREPARATION METHOD THEREOF, AND DRILLING FLUID AND USE THEREOF

Southwest Petroleum Unive...

1. A micro-nano composite plugging agent for drilling fluid,containing nanometer calcium carbonate, nanometer zinc oxide whiskers, nanometer emulsified paraffin, a flocculating agent, and a lubricant, wherein in the composite plugging agent, the nanometer calcium carbonate is in 10-36 parts by weight, the nanometer zinc oxide whiskers are in 20-40 parts by weight, the nanometer emulsified paraffin is in 30-70 parts by weight, the flocculating agent is in 1-10 parts by weight, and the lubricant is in 5-20 parts by weight.
US Pat. No. 10,335,395

METHODS OF ADMINISTERING IMMUNOSUPPRESSANTS HAVING A SPECIFIED PHARMACODYNAMIC EFFECTIVE LIFE AND THERAPEUTIC MACROMOLECULES FOR THE INDUCTION OF IMMUNE TOLERANCE

Selecta Biosciences, Inc....

1. A method comprising:administering an immunosuppressant to a subject in a first class of subjects at an administration dose that provides an administration pharmacodynamic effective-life, with respect to a therapeutic macromolecule, the duration of which pharmacodynamic effective-life ranges from a minimum of 20 hours to a maximum of 1 month; and
administering the therapeutic macromolecule to the subject within the duration of the administration pharmacodynamic effective-life of the immunosuppressant;
wherein the therapeutic macromolecule and immunosuppressant are not attached to one another, and the therapeutic macromolecule is not attached to a synthetic nanocarrier.
US Pat. No. 10,336,679

POLYMORPHIC FORMS OF SODIUM BENZOATE AND USES THEREOF

SyneuRx International (Ta...

1. A polymorphic form of sodium benzoate, which has an X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 5.9, 30.2, and 31.2 degrees, wherein the X-ray diffraction pattern further comprises characteristic peaks at a reflection angle 2? of approximately 4.3, 7.1, 8.6, 10.1, 10.7, 12.9, 13.8, 14.4, 17.2, 17.7, 18.5, 21.5, 22.0, 22.6, 23.7, 25.1, 25.9, 26.2, 26.9, 27.9, 28.2, 28.8, 29.1, 29.7, 33.2, 34.9, 35.8, 36.1, and 39.3 degrees, and wherein the polymorphic form of sodium benzoate has a water solubility of 666 mg/ml at ambient temperature.
US Pat. No. 10,338,474

UNDERLYING ABSORBING OR CONDUCTING LAYER FOR EBEAM DIRECT WRITE (EBDW) LITHOGRAPHY

Intel Corporation, Santa...

1. A method of patterning a resist layer using an e-beam tool, the method comprising:providing a wafer having a resist layer directly on an underlying conducting layer; and
performing ebeam direct write lithography to pattern the resist layer with incident electrons, wherein the conducting layer reflects or conducts away a substantial portion of the incident electrons to diminish backscatter.
US Pat. No. 10,336,681

PROCESS FOR THE SYNTHESIS OF DIALKYL CARBONATES

1. A process for the synthesis of dialkyl carbonates, using a catalyst of AB oxides supported on a support selected from carbon, neutral alumina or silica, the process comprising the steps of:a. charging alkyl carbamate and aliphatic alcohol (1:5) in a high pressure reactor, adding the catalyst and heating the reactor to 100-300° C. with stirring; and
b. removing ammonia formed over the period of reaction and cooling the reaction to room temperature to obtain the desired alkyl carbonate;
wherein the dialkyl carbonates are dimethyl carbonate (DMC), diethyl carbonate (DEC), dipropyl carbonate (DPC) or dibutyl carbonate (DBC); and
wherein A and B are selected from rare earth, transition metals and alkaline earth metals and the AB oxide has an A:B ratio ranging from 0.5:10 to 10:0.5.
US Pat. No. 10,336,938

LIQUID CRYSTAL COMPOSITION

Sumitomo Chemical Company...

1. A liquid crystal composition comprising a polymerizable liquid crystal compound (A) having 5 or more ring structures in its main chain, a polymer (B) of the polymerizable liquid crystal compound (A) having 5 or more ring structures in its main chain, and an organic solvent capable of dissolving the polymerizable liquid crystal compound (A) and the polymer (B),wherein the polymer (B) has an area percentage value determined by gel permeation chromatography (GPC) of 0.01% or more and 40% or less, and
wherein the polymerizable liquid crystal compound (A) is a polymerizable liquid crystal compound represented by the following formula (A):
P1—F1?B1-A1?mE1-G1-D1-Ar-D2-G2-E2?A2-B2?nF2—P2  (A)
in formula (A), m and n each independently represent an integer of 0 to 3;
B1, B2, D1, D2, E1, and E2 each independently represent —CR1R2—, —CH2—CH2—, —O—, —S—, —CO—O—, —O—CO—, —O—CO—O—, —C(?S)—O—, —O—C(?S)—, —O—C(?S)—O—, —CO—NR1—, —NR2—CO—, —O—CH2—, —CH2—O—, —S—CH2—, —CH2—S—, or a single bond, and R1 and R2 each independently represent a hydrogen atom, a fluorine atom, or an alkyl group having 1 to 4 carbon atoms;
A1, A2, G1, and G2 each independently represent a divalent alicyclic hydrocarbon group having 3 to 16 carbon atoms or a divalent aromatic hydrocarbon group having 6 to 20 carbon atoms, the hydrogen atom contained in the alicyclic hydrocarbon group and the aromatic hydrocarbon group is optionally substituted with a halogen atom, —R3, —OR3, a cyano group, or a nitro group, —CH2— contained in the alicyclic hydrocarbon group is optionally substituted with —O—, —S—, —NH—, or —NR4—, and —CH(—)— contained in the alicyclic hydrocarbon group is optionally substituted with —N(—)—, R3 and R4 each independently represent an alkyl group having 1 to 4 carbon atoms, and the hydrogen atom contained in the alkyl group is optionally substituted with a fluorine atom;
F1 and F2 each independently represent an alkanediyl group having 1 to 12 carbon atoms, the hydrogen atom contained in the alkanediyl group is optionally substituted with —OR3 or a halogen atom, and —CH2— contained in the alkanediyl group is optionally substituted with —O— or —CO—;
P1 and P2 each independently represent a hydrogen atom or a polymerizable group (provided that at least one of P1 and P2 represents a polymerizable group), and
Ar is a divalent aromatic group which is optionally substituted, and at least one of a nitrogen atom, an oxygen atom, or a sulfur atom is contained in the aromatic group.
US Pat. No. 10,340,526

NONAQUEOUS LITHIUM-TYPE POWER STORAGE ELEMENT

Asahi Kasei Kabushiki Kai...

1. A nonaqueous lithium-type storage element, comprising a positive electrode containing a lithium compound other than a positive electrode active material, a negative electrode, a separator, and a nonaqueous electrolytic solution containing lithium ions,wherein the positive electrode comprises a positive electrode power collector, and a positive electrode active material layer located at one surface or both surfaces of the positive electrode power collector, and containing the positive electrode active material,
the negative electrode comprises a negative electrode power collector, and a negative electrode active material layer located at one surface or both surfaces of the negative electrode power collector, and containing the negative electrode active material,
2?C?300, where C (ppm) is concentration of Na and/or K element, contained in the positive electrode active material layer, and
1.0?D?15, 10?E?100, 0.2?C/D?38, and 0.1?C/E?7.2, where D (g/m2) is basis weight of the lithium compound other than the positive electrode active material, contained in the positive electrode active material layer, per one surface of the positive electrode, and E (g/m2) is basis weight of the positive electrode active material contained in the positive electrode active material layer, per one surface of the positive electrode.
US Pat. No. 10,335,402

SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS

Takeda Pharmaceutical Com...

1. A method of treating irritable bowel syndrome or inflammatory bowel disease comprising administering to a patient in need thereof a compound selected from:Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetate,
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(2,6-Difluorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chloro-2-fluorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((3,5-diethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)-2-(4-(trifluoromethoxy)phenyl)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-3-methylpiperidin-4-ylidene)acetonitrile,
4-(4-Chloro-2-fluorobenzylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(4-Chloro-2-fluorobenzylidene)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(1-(4-Chlorophenyl)ethylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(4-Chlorobenzylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
2-(4-Chlorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
4-((4-Chlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((3-Chloro-4-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((2,4-Dichlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((4-Chloro-2-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((2,4-Difluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
3-((1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)fluoromethyl)quinoline, and pharmaceutically acceptable salts of any one thereof.
US Pat. No. 10,336,685

CRYSTALLINE MODIFICATION OF PROPANIL

UPL LIMITED, Mumbai (IN)...


US Pat. No. 10,336,941

IMPACT-MODIFIED HYDROXYAPATITE AS FLAME RETARDANT POLYMER FILLERS

International Business Ma...

1. An impact resistant hydroxyapatite-based compound comprising hydroxyapatite functionalized with optionally substituted poly(butadiene-co-styrene).
US Pat. No. 10,335,404

METHODS OF TREATING CANCER PATIENTS WITH FARNESYLTRANSFERASE INHIBITORS

Kura Oncology, Inc., San...

1. A method of treating a H-Ras mutant head and neck squamous cell carcinoma (HNSCC) in a subject, consisting of administering a therapeutically effective amount of a farnesyltransferase inhibitor (FTI) to said subject, wherein said HNSCC is at an advanced stage, metastatic, relapsed or refractory.
US Pat. No. 10,335,405

NON-BURST RELEASING PHARMACEUTICAL COMPOSITION

Patheon Softgels, Inc., ...

1. An abuse deterrent oral pharmaceutical composition comprising a tamper resistant controlled release matrix comprising:(a) about 50% to about 65% by weight oleic acid or glyceryl monolinoleate;
(b) about 25% to about 35% by weight polyethylene oxide;
(c) 1% to about 5% by weight ethylcellulose having a viscosity of about 20 cP;
(d) 1% to about 5% by weight sodium lauryl sulfate; and
(e) 1.5% to about 10% by weight hydrocodone;
wherein the matrix is resistant to tampering and prevents the burst release of the one or more active pharmaceutical ingredients and is encapsulated in a capsule shell.
US Pat. No. 10,335,407

USE OF FLIBANSERIN IN THE TREATMENT OF OBESITY

Sprout Pharmaceuticals, I...

1. A pharmaceutical composition comprising a) an active substance being not flibanserin, selected from the group comprising pioglitazone or a pharmaceutical acceptable salt thereof, troglitazone, rosiglitazone or a pharmaceutical acceptable salt thereof, JTT-501, GI-262570, MCC-555, YM-440, DRF-2593, BM-13-1258, KRP-297, R-119702, GW-1929, tolbutamide, chloropropamide, tolazamide, acetohexamide, glyclopyramide, an ammonium salt of glyclopyramide, glibenclamide, gliclazide, glimepiride, repaglinide, nateglinide, mitiglinide, JTT-608, metformin, bovine insulin, porcine insulin, semisynthetic human insulin, genetically-engineered human insulin, acarbose, voglibose, miglitol, emiglitate, AJ-9677, BMS-196085, SB-226552, AZ40140, tolrestat, epalrestat, imirestat, zenarestat, SNK-860, zopolrestat, ARI-50i, AS-3201, NGF, LY-333531, LAF237, MK431, 815541, 823093, 825964, liraglutide, exenatide, AVE-2268, T-1095, mazindol, baiamine, NGD-95-1, lipstatin, rimonabant, phenylpropanolamine, ephedrine, pseudroephedrine, dexfenfluramine, fenfluramine, BVT.933, APD356, bromocriptine, pramipexol, dehydroepiandrosterone, exendin, AC 2993, CJC-1131, ZP10, GRT0203Y, captopril, enalapril, alacepril, delapril, lisinopril, imidapril, benazepril, cilazapril, temocapril, trandolapril, manidipine, nifedipine, amlodipine, efonidipine, nicardipine, levcromakalim, L-27152, AL0671, NIP-121, telmisartan, losartan, candesartan cilexetil, valsartan, irbesartan, CS-866, E4177, pravastatin or a pharmaceutical acceptable salt thereof, simvastatin or a pharmaceutical acceptable salt thereof, lovastatin or a pharmaceutical acceptable salt thereof, atorvastatin or a pharmaceutical acceptable salt thereof, fluvastatin or a pharmaceutical acceptable salt thereof, lipantil or a pharmaceutical acceptable salt thereof, cerivastatin or a pharmaceutical acceptable salt thereof, itavastatin or a pharmaceutical acceptable salt thereof, ZD-4522 or a pharmaceutical acceptable salt thereof, bezafibrate, clinofibrate, clofibrate, simfibrate, or mixtures thereof and b) flibanserin, optionally in form of the free base, and/or a pharmacologically pharmaceutically acceptable acid addition salt thereof.
US Pat. No. 10,335,408

COMPOSITIONS AND METHODS OF USING NINTEDANIB FOR IMPROVING GLAUCOMA SURGERY SUCCESS

Cloudbreak Therapeutics, ...

1. A method for improving success rate of glaucoma surgery, comprising administering to an eye of a subject in need thereof a therapeutically effective amount of nintedanib or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,336,690

METHODS AND SYSTEMS FOR PROCESSING AN ACETONITRILE WASTE STREAM

HONEYWELL INTERNATIONAL I...

1. A method for processing an acetonitrile waste stream, the method comprising the steps of:providing an acetonitrile waste stream containing acetonitrile, toluene, acetic acid, propanenitrile, organic and/or inorganic iodine-containing compounds, and organic and/or inorganic sulfur-containing compounds;
fractionating the acetonitrile waste stream to produce a single overhead fraction comprising the pyridine, organic and/or inorganic iodine-containing compounds, organic and/or inorganic sulfur-containing compounds, and from about 75% to about 100% of the acetonitrile contained in the acetonitrile waste stream;
condensing the single overhead fraction to produce a condensed single overhead fraction;
contacting the condensed single overhead fraction with a silver-exchange zeolite to remove the organic and/or inorganic iodine-containing compounds; and
contacting the condensed single overhead fraction with a basic anion exchange resin to remove the organic and/or inorganic sulfur-containing compounds.
US Pat. No. 10,335,411

ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION

Millennium Pharmaceutical...

1. A method of treating cancer, comprising administering to a patient in need of such treatment a combination of ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio)phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (Compound 1) or a pharmaceutically acceptable salt thereof and radiation, wherein the cancer is selected from the group consisting of breast cancer, colorectal cancer, ovarian cancer, lung cancer, prostate cancer, head and neck cancer, gastric cancer, esophageal cancer, gastro-esophageal junction cancer, multiple myeloma, and non-Hodgkin's lymphoma; andwherein the radiation is particle radiation or administered by external beam radiation.
US Pat. No. 10,338,488

IMAGE FORMING APPARATUS

FUJI XEROX CO., LTD., To...

1. An image forming apparatus comprising:an image holding member;
a charging device that charges a surface of the image holding member;
an electrostatic charge image forming device that forms an electrostatic charge image on the charged surface of the image holding member;
a developing device that includes an electrostatic charge image developer containing an electrostatic charge image developing toner and develops the electrostatic charge image to form a toner image on the surface of the image holding member;
a transfer device that transfers the toner image onto a recording medium; and
a fixing device that fixes the toner image on the recording medium, wherein
the fixing device includes a fixing belt that comes into contact with the toner image transferred to the surface of the recording medium, a rotational member that contacts with the outer surface of the fixing belt such that a contact area is formed between the rotational member and the fixing belt and that rotates together with the fixing belt to transport the recording medium, and a heater that is disposed so as to face the inner surface of the fixing belt to heat the contact area formed between the rotational member and the fixing belt;
the toner contains a binder resin that includes:
(i) a crystalline resin, and
(ii) an amorphous polyester resin, in which an amount of an alkylene oxide adduct of bisphenol A, if present, is not more than 5 mol %, relative to a total amount of polyhydric alcohols;
a tetrahydrofuran-soluble component of toner particles has a weight average molecular weight Mw and a number average molecular weight Mn, the weight average molecular weight Mw is in the range of 25000 to 60000, and Mw/Mn is in the range of 5 to 10; and
the toner has infrared absorption spectrum characteristics including: (i) a ratio of an absorbance at a wavelength of 1500 cm?1 to an absorbance at a wavelength of 720 cm?1 that is 0.6 or less, and (ii) a ratio of an absorbance at a wavelength of 820 cm?1 to an absorbance at a wavelength of 720 cm?1 that is 0.4 or less.
US Pat. No. 10,340,026

QTL RESPONSIBLE FOR TOMATO FRUIT FIRMNESS

Syngenta Participations A...

1. A method for selecting a cultivated Solanum lycopersicum tomato plant with fruit having increased firmness as compared with fruit from a control Solanum lycopersicum tomato plant, the method comprising:a. detecting in the cultivated Solanum lycopersicum tomato plant the presence of QTL1, wherein detecting the presence of QTL1 comprises:
i. providing a sample of genomic DNA from the cultivated Solanum lycopersicum tomato plant; and
ii. detecting in the sample of genomic DNA at least one DNA marker linked to QTL1 selected from DNA markers TG599, NT3374, TG246, and NT5880, wherein:
DNA marker TG599 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 19 and a reverse primer of SEQ ID NO: 20,
DNA marker NT3374 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 7 and a reverse primer of SEQ ID NO: 8,
DNA marker TG246 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 17 and a reverse primer of SEQ ID NO: 18, and
DNA marker NT5880 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 9 and a reverse primer of SEQ ID NO: 10; and
b. selecting a cultivated Solanum lycopersicum tomato plant comprising QTL1, thereby selecting a cultivated Solanum lycopersicum tomato plant with fruit having increased firmness as compared with a control Solanum lycopersicum tomato plant that does not comprise QTL1.
US Pat. No. 10,335,414

USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS

Indiana University Resear...

1. A method to slow the progression of or ameliorate hydrocephalus in a patient in need thereof, the method comprising:a) administering a safe and effective amount of at least one Transient Receptor Potential Vanilloid Receptor 4 (TRPV4) antagonist, or a pharmaceutically-acceptable salt thereof, to the patient, wherein the at least one TRPV4 antagonist is RN-1734, HC-067047, or both RN-1734 and HC-067047; and
b) slowing the progression of or ameliorating hydrocephalus in the patient.
US Pat. No. 10,340,027

IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS

Koninklijke Philips N.V.,...

1. A method for identifying and treating a patient responsive to cancer therapy comprising:receiving a primary dataset comprising data on at least one stratifying biomedical marker and/or a network node, the primary dataset being associated with a healthy subject;
receiving a secondary dataset comprising data on at least one stratifying biomedical marker and/or a network node, the secondary dataset being associated with a subject affected by a medical condition which may be treatable by cancer therapy;
comparing said primary dataset with said secondary dataset and/or with external datasets to generate a significance value for said stratifying biomedical markers;
identifying a network among the stratifying biomedical markers with other members of the network based on the significance value supplemented with a correction procedure;
ranking members of the identified network according to a ranking score based upon a reference network metric to identify network nodes and/or high ranking network members associated with the medical condition of the secondary subject;
determining potential responsiveness of the patient to cancer therapy based on the association between the identified network nodes and/or high ranking network members and the stratifying biomedical markers;
selecting and treating patients with a cancer therapy based on the identified high ranking network members and the stratifying biomedical markers.
US Pat. No. 10,340,028

METHOD FOR DESIGNING RNA BINDING PROTEIN UTILIZING PPR MOTIF, AND USE THEREOF

1. A method for predicting the function for the fertility restoration of a PPR protein obtained from a test plant, based on the predetermined PPR protein relating to fertility, wherein the PPR protein is a protein containing one or more of PPR motifs each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1:(HelixA)-X-(HelixB)-L  (Formula 1)
wherein, in formula 1, Helix A is a moiety of 12-amino acid length capable of forming an ?-helix structure, and is represented by the formula 2:
A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12  (Formula 2)
wherein, in the formula 2, A1 to A12 independently represent an amino acid;
wherein, in the formula 1, X is a moiety of 1- to 9-amino acid length and is optional;
wherein, in the formula 1, Helix B is a moiety of 11- to 13-amino acid length capable of forming an ?-helix structure; and
wherein, in the formula 1, L is a moiety of 2- to 7-amino acid length represented by the formula 3;
Lvii-Lvi-Lv-Liv-Liii-Lii-Li  (Formula 3)
wherein, in the formula 3, Li to Lvii independently represent an amino acid, and Liii to Lvii are optional,
said method comprising
extracting an amino acid sequence of each of three amino acids A1, A4 and Lii or two amino acids A4 and Lii from an amino acid sequence of a PPR motif in the test plant,
determining whether the three amino acids A1, A4 and Lii, or two amino acids A4 and Lii in the test plant are the same as the corresponding amino acids in the predetermined PPR protein relating to fertility.
US Pat. No. 10,335,416

DACTINOMYCIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA

1. A method for treating acute myeloid leukemia (AML) in a subject in need thereof comprising administering to the subject a therapeutically-effective amount of a composition comprising dactinomycin, wherein a therapeutically-effective amount of the composition is between 1 and 30 ?g/kg/day, inclusive of the endpoints wherein the AML is NPMI-mutated AML.
US Pat. No. 10,340,544

ION-EXCHANGE MEMBRANE MADE OF A BIAXIALLY STRETCHED ?-POROUS FILM

1. An ion exchange membrane containing a biaxially orientated single or multi-layered ?-porous polypropylene film which contains at least one ?-nucleating agent and comprises an ion-conducting polymer and exhibits a Gurley value of at least 30,000 s.
US Pat. No. 10,335,421

TOPICAL WOUND CARE FORMULATION

1. A topical formulation, comprising:(a) silver sulfadiazine;
(b) urogastrone;
(c) camphor;
(d) menthol; and
(e) eucalyptus.
US Pat. No. 10,336,959

LUBRICANTS WITH CALCIUM-CONTAINING DETERGENT AND THEIR USE FOR IMPROVING LOW SPEED PRE-IGNITION

AFTON CHEMICAL CORPORATIO...

1. A lubricating oil composition comprising:greater than 50 wt. % of a base oil of lubricating viscosity;
at least 0.3 wt. % of an overbased calcium sulfonate detergent having a total base number of greater than 225 mg KOH/g, measured by the method of ASTM D-2896, and
at least 0.2 wt. % of a low-based/neutral detergent having a total base number of up to 175 mg KOH/g, measured by the method of ASTM D-2896,
wherein a total amount of calcium from the overbased calcium sulfonate detergent and the low-based/neutral detergent ranges from greater than 1100 ppm by weight to less than 2400 ppm by weight based on a total weight of the lubricating oil composition;
a total amount of calcium from the overbased calcium sulfonate detergent is from 900 ppm to 1625 ppm by weight, based on the total weight of the lubricating oil composition; and
a ratio of the ppm of calcium, by weight, provided to the lubricating oil composition by the low-based/neutral detergent to the ppm of calcium, by weight, provided to the lubricating oil composition by the overbased calcium sulfonate detergent, is from 0.08 to 0.4.
US Pat. No. 10,335,422

SMALL MOLECULES THAT PROMOTE SKIN REGENERATION

International Stem Cell C...

5. A method for promoting skin regeneration, comprising administering to a subject an effective amount of a compound that increases protein secretion, wherein the small molecule is an adenosine transport inhibitor, thereby promoting skin regeneration.
US Pat. No. 10,339,267

SYSTEMS AND METHODS FOR DETERMINING THE PROBABILITY OF A PREGNANCY AT A SELECTED POINT IN TIME

CELMATIX, INC., New York...

1. A system for determining a probability of achieving a pregnancy at a selected point in time, the system comprising:a central processing unit (CPU); and
storage coupled to said CPU for storing instructions that when executed by the CPU cause the CPU to:
train a prognosis predictor, using training data from a population that includes women who ceased pregnancy attempts after one or more reproductive cycles without conception and women who continued pregnancy attempts until live birth, to determine a correlation between fertility-associated characteristics and known pregnancy outcomes, the fertility-associated characteristics comprising phenotypic traits, fertility-associated interventions, and pregnancy outcomes;
accept as input, data representative of a plurality of fertility-associated phenotypic traits of a female subject;
analyze the input data using the prognosis predictor;
provide, based on the analysis, a probability of achieving a pregnancy at a selected point in time; and
treating the female subject with a fertility treatment based on the probability of achieving a pregnancy.
US Pat. No. 10,335,424

COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING DISEASE

ANTECIP BIOVENTURES II LL...

1. A method of treating arthritis comprising orally administering a dosage form comprising zoledronic acid in an acid form or a salt form to a human being in need thereof, wherein the bioavailability of zoledronic acid in the dosage form is about 1.5% to 2.3%, as determined when orally administered to a human being who has fasted in a manner that maximizes the bioavailability of zoledronic acid.
US Pat. No. 10,336,963

AROMATIC TETRAHEDRAL BORATE COMPOUNDS FOR LUBRICATING COMPOSITIONS

THE LUBRIZOL CORPORATION,...

1. A lubricating composition comprising:an oil of lubricating viscosity; and
an ionic tetrahedral borate compound comprising an ammonium cation and a tetrahedral borate anion which comprises a boron atom, the boron atom having at least one aromatic bidentate di-oxo ligand, and
wherein the ammonium cation has a molecular weight of at least 260 g/mol and is derived from a dispersant selected from polyisobutenyl succinimide, polyamine dispersants, and solubilized fatty acid amines.
US Pat. No. 10,336,964

GREASE COMPOSITION AND BEARING

KYODO YUSHI CO., LTD., F...

1. A grease composition for bearing comprising a base oil, a urea-containing thickener and a seizing life extending additive, whereinthe base oil is alkyldiphenyl ether,
the urea-containing thickener is represented by the following formula (1):
R1NH—CO—NH—R3—NH—CO—NHR2  (1)
wherein R1 and R2, which may be the same or different, represent an aryl group having 6 or 7 carbon atoms, and R3 is
—C6H4—CH2—C6H4—, —C6H4—, or C6H3(CH3)—,
wherein the seizing life extending additive extends seizing life of the grease composition and comprises an overbased Ca or Na sulfonate,
wherein an amount of the base oil is 79.6 mass % or more with respect to the total amount of the grease composition,
wherein an amount of the urea-containing thickener is 19 to 20 mass % with respect to the total amount of the grease composition and
wherein an amount of the overbased Ca or Na sulfonate is 0.1 to 0.4 mass % with respect to the total amount of the grease composition.
US Pat. No. 10,340,553

ELECTROLYTES FOR WIDE OPERATING TEMPERATURE LITHIUM-ION CELLS

California Institute of T...

1. An electrolyte for use in an electrochemical cell, the electrolyte comprising a mixture of:15-30% by volume a cyclic carbonate, wherein the cyclic carbonate is a non-fluorinated cyclic carbonate;
15-30% by volume a non-cyclic carbonate;
40-70% by volume a linear ester;
a lithium salt in a concentration from 0.5 M to 1.5 M; and
lithium oxalate;wherein the cyclic carbonate, the non-cyclic carbonate and the linear ester are present in a combined total volume of 100 vol % and the lithium oxalate is present at a concentration selected over the range of 0.05 M to 0.25 M.
US Pat. No. 10,336,966

FRAGRANCE COMPOSITIONS AND USES THEREOF

1. A composition wherein:(i) the fragrance component is present in an amount from about 1 wt % to about 30 wt %, relative to the total weight of the composition; and wherein the fragrance component comprises:
(a) at least one low volatile fragrance material present in an amount less than about 30 wt %, relative to the total weight of the fragrance component;
(b) at least one moderate volatile fragrance material present in an amount of at least about 45 wt %, relative to the total weight of the fragrance component; and
(c) at least one high volatile fragrance material present in an amount of less than about 25 wt %, relative to the total weight of the fragrance component;
(ii) at least one fragrance modulator present in the amount of from about 0.5 wt % to about 18 wt %, relative to the total weight of the composition;
(iii) the volatile solvent present in an amount of from about 55 wt % to about 75 wt %, relative to the total weight of the composition; and
(iv) the water present in an amount of from 0 wt % to about 20 wt %, relative to the total weight of the composition.
US Pat. No. 10,335,429

ASSOCIATION OF BETA-GLUCANS AND ARABINOXYLANS

Generale Biscuit, Clamar...

1. A biscuit comprising a first cereal comprising beta-glucans and a second cereal comprising arabinoxylans, wherein the second cereal is different from the first cereal, wherein the biscuit comprises from 4 to 12 wt % of the arabinoxylans and from 9 to 18 wt % of the beta-glucans, and wherein the ratio of the beta-glucans in the first cereal to the arabinoxylans in the second cereal is from 11:9 to 7:3.
US Pat. No. 10,336,711

PROLYL HYDROXYLASE INHIBITORS

GlaxoSmithKline LLC, Wil...

1. A method of treating anemia associated with cancer in a human which comprises administering to such human N-[(1,3-dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine, or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,336,967

LAUNDRY DETERGENT COMPOSITION COMPRISING BRANCHED ALKYL ALKOXYLATED SULPHATE

1. A solid free-flowing particulate laundry detergent composition comprising:(a) C11-C13 alkyl benzene sulphonate detersive surfactant;
(b) C11-C15 alkyl ethoxylated sulphate having an average degree of ethoxylation of from about 0.5 to about 3.0, and comprising a C1-C5 alkyl branch in the position C2, and having an average degree of branching of from about 0.01 to 0.12;
(c) wherein the composition is substantially free of zeolite builder; and
(d) wherein the composition is substantially free of phosphate builder.
US Pat. No. 10,336,969

PYRITHIONE PRESERVATIVE SYSTEM IN SOLID RINSE AID PRODUCTS

Ecolab USA Inc., Saint P...

1. A solid rinse aid composition comprising:a) from about 0.05 wt-% to about 20 wt-% of a pyrithione preservative;
b) from about 5 wt-% to about 80 wt-% of hardening agent comprising a solid acid;
c) two or more nonionic surfactants comprising one or more alcohol alkoxylates having the formula R—O—(CH2CH2O)n—H, wherein R is a (C1-C12) alkyl group and n is an integer in the range of 1 to 100, and an ethylene oxide-propylene oxide (EO/PO) copolymer; and
d) additional functional ingredients,
wherein the composition is a solid concentrate, and the solid concentrate generates a stable and aqueous use solution having a neutral to acidic pH.
US Pat. No. 10,336,714

PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF METSULFURON-METHYL AND USE OF THE SAME

Rotam Agrochem Internatio...

1. A crystalline modification I of metsulfuron-methyl (methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoate) obtained by (i) dissolving metsulfuron-methyl in an amorphous state into at least one of methanol or ethanol to create a slurry, (ii) heating the slurry to prepare a homogeneous solution, (iii) filtering the homogeneous solution to remove any insoluble particles, (iv) cooling the solution to form crystals, (v) mixing the cooled crystalline solution, (vi) filtering the crystalline solution to obtain filtered crystals, (vii) washing the filtered crystals with said at least one of methanol or ethanol, and (viii) drying the washed crystals under vacuum, wherein the obtained crystalline modification I of metsulfuron-methyl exhibiting each of the following reflexes as 2? values in X-ray powder diffractogram recorded using Cu-K? radiation at 25° C.:2?=6.28±0.2  (1)
2?=12.61±0.2  (2)
2?=13.50±0.2  (3)
2?=16.59±0.2  (4)
2?=17.66±0.2  (5)
2?=19.70±0.2  (6)
2?=21.63±0.2  (7)
2?=21.84±0.2  (8)
2?=23.22±0.2  (9)
2?=24.21±0.2  (10)
2?=27.25±0.2  (11)
2?=27.98±0.2  (12), and
2?=29.25±0.2  (13); and
wherein the crystalline modification I of metsulfuron-methyl exhibits a Differential Scanning Calorimeter (DSC) thermogram having an endothermic melting peak with onset at 170.5° C. and peak maximum at 173.6° C.
US Pat. No. 10,336,970

LIQUID DETERGENT COMPOSITION COMPRISING AN ENCAPSULATED ENZYME

1. A water-soluble unit dose article comprising a water-soluble film and a liquid detergent composition comprising between 25% and 55% by weight of the liquid detergent composition of a non-soap surfactant, wherein the non-soap surfactant comprises an anionic surfactant and a non-ionic surfactant and wherein the weight ratio of anionic surfactant to non-ionic surfactant is between 23:1 to 2.5:1; andwherein the liquid detergent composition comprises an encapsulated enzyme.
US Pat. No. 10,340,045

METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR AUTOIMMUNE SYSTEM CONDITIONS

uBiome, Inc., San Franci...

1. A method for at least one of characterizing, diagnosing, and treating an autoimmune condition of a subject, the method comprising:providing sampling kits to a population of subjects at remote locations, each sampling kit including a sample container having a pre-process reagent component;
receiving an aggregate set of samples from the sampling kits of the population of subjects;
with a next generation sequencing platform of a sample processing system, generating sequence datasets upon sequencing nucleic acid content of microorganism portions of the aggregate set of samples;
generating a microbiome feature dataset for the population of subjects based upon the sequence datasets for the population of subjects;
generating a characterization model of the autoimmune condition from features extracted from the microbiome feature dataset and a supplementary dataset informative of characteristics associated with the autoimmune condition;
characterizing the subject with the autoimmune condition upon processing a sample from the subject according to the characterization model; and
at an output device associated with the subject, providing a therapy to the subject with the autoimmune condition.
US Pat. No. 10,335,433

NDGA POLYMERS AND METAL COMPLEXES THEREOF

MiMedx Group, Inc., Mari...

1. A biologically compatible metal-nordihydroguaiaretic acid (NDGA) polymer complex, said complex comprising a metallic ion and a NDGA moiety, wherein said metallic ion is bound to the NDGA moiety of the polymer, wherein said complex is substantially insoluble in biological fluids; and wherein the complex is in a powdered form.
US Pat. No. 10,336,715

PHOSPHORIC ACID LOADED COVALENT ORGANIC FRAMEWORK AND A PROCESS FOR THE PREPARATION THEREOF

1. A process for preparing phosphoric acid loaded covalent organic framework with high stability and high proton conductivity comprising steps of:a) dispersing 1,3,5-triformylphloroglucinol (Tp) and diamine compound in solvent by ultrasonication for 10 minutes followed by degassing the solution;
b) heating the solution as obtained in step (a) in oven for 3-5 days at temperature in a range of 100° C. to 120° C. followed by washing and drying under vacuum at temperature in a range of 120° C. to 150° C. for period in a range of 12 h to 18 h to obtain desired covalent organic framework with at least one basic anchoring site;
c) immersing the covalent organic framework of step (b) in H3PO4 (PA) for period in a range of 1 h to 5 h followed by washing to remove surface absorbed phosphoric acid and activating overnight for period in a range of 12 h to 18 h at temperature in a range of 60° C. to 80° C. under vacuum to obtain phosphoric acid loaded covalent organic framework.
US Pat. No. 10,336,971

ODOR REDUCTION

1. A method for reducing odor generated by activity of a lipase, wherein said method comprises a step of adding to said lipase a peptide capable of binding to said lipase,wherein said lipase has the amino acid sequence comprising SEQ ID NO: 1, or a sequence identity of at least 90% with SEQ ID NO: 1; and
wherein said peptide has the amino acid sequence comprising SEQ ID NO: 2, or a sequence identity of at least 90% with at least one major lipase contact zone of SEQ ID NO: 2.
US Pat. No. 10,335,434

ISCHEMIC TISSUE CELL THERAPY

University of South Flori...

1. A method of treating nerve damage in a patient in need thereof consisting of:obtaining a therapeutic consisting of an isolated population of CD14+ monocyte lineage cells from human umbilical cord blood cells (hUCBCs); and
administering via transplantation the therapeutic consisting of the isolated population of CD14+ monocyte lineage cells to the patient in need thereof.
US Pat. No. 10,336,716

THERMODYNAMICALLY STABLE CRYSTAL MODIFICATION OF 2-METHYL-N-(5-METHYL-1, 3, 4-OXADIAZOL-2-YL)-3-(METHYLSULFONYL)-4-(TRIFLUOROMETHYL)BENZAMIDE

BAYER CROPSCIENCE AKTIENG...


US Pat. No. 10,336,972

METHOD OF PRETREATING FABRICS

1. A method of laundering a fabric comprising the steps of:(a) applying a laundry pretreat composition to a stain on a fabric in a pretreat step; and
(b) washing the fabric from step (a) in an automatic or semiautomatic washing machine or in a hand wash operation;
wherein said laundry pretreatment composition comprises:
i. between about 0.0001% and about 8% by weight of the composition of a non-surfactant benefit agent,
the non-surfactant benefit agent comprising a hueing dye selected from a chemical class selected from the group consisting of acridine, anthraquinone, benzodifurane, benzodifuranone, carotenoid, diazahemicyanine, diphenylmethane, formazan, hemicyanine, indigoids, methane, naphthoquinone, nitro, nitroso, oxazine, phthalocyanine, triarylmethane, triphenylmethane, and mixtures thereof;
ii. between about 40% and about 80% by weight of the composition of an alkoxylated alkyl surfactant system, wherein the alkoxylated alkyl surfactant comprise a first alkoxylated alkyl surfactant and a second alkoxylated alkyl surfactant, wherein:
I. the first surfactant has the general structure R-A, where R is a linear or branched alkyl chain having a chain length of between about 6 and about 18 carbon atoms, A is at least one alkoxy group having an average degree of alkoxylation of between about 2 and about 12 and wherein the alkoxy groups consist of identical repeat alkoxy groups or identical repeat alkoxy group blocks wherein a block comprises at least two alkoxy groups;
II. the second surfactant has the general structure R?-E-C, wherein R? is a linear or branched alkyl chain having a chain length of between about 6 and about 18 carbon atoms, E is an ethoxy chain consisting of between about 2 and about 12 ethoxy groups and C is an end cap, wherein the end cap is selected from:
a. an alkyl chain consisting of between 1 and 8 alkoxy groups selected from propoxy groups, butoxy groups and a mixture thereof;
b. an —OH group;
c. a linear or branched alkyl chain of the general formula R? wherein R? comprises between about 1 and about 8 carbon atoms;
d. or a mixture thereof; and
iii. between 0% and about 40% by weight of the composition of a solvent, wherein the solvent is selected from polar protic solvents wherein the non-surfactant benefit agent has a hydrophilic index, and the first surfactant has a hydrophilic index and wherein the hydrophilic index of the non-surfactant benefit agent is within about 0.7 and about 1.5 times that of the hydrophilic index of the first surfactant.
US Pat. No. 10,335,435

METHOD FOR ENDOSCOPICALLY DELIVERING STEM CELLS TO THE BRAIN USING AN INTRANASAL, INJECTABLE APPROACH

1. A method for delivery of therapeutic stem cells to a central nervous system of a mammal having a blood-brain barrier and a nose with a nasal cavity, comprising:inserting an endoscopic device into said nasal cavity;
injecting said therapeutic stem cells intranasally into nasal structure within the nasal cavity of the nose using a needle and syringe under endoscopic guidance; and
enabling said therapeutic stem cells to access the central nervous system by bypassing the blood-brain barrier,
wherein injecting said therapeutic stem cells comprises:
injection of said stem cells as a stem cell solution solely within mucosal and sub-mucosal tissue covering said nasal structure,
causing said mucosal and sub-mucosal tissue to balloon out upon injection of said stem cell solution;
visually observing the ballooning out of said mucosal and sub-mucosal tissue with said endoscopic device; and
determining correct depth of placement of the stem cell solution solely within said mucosal and sub-mucosal tissue upon direct visual observation of the ballooning out of said tissue.
US Pat. No. 10,336,973

ARTICLES COMPRISING WATER-SOLUBLE POLYVINYL ALCOHOL FILM WITH PLASTICIZER BLEND AND RELATED METHODS

1. An article comprising:a. a water-soluble film, wherein the water-soluble film comprises:
a polyvinyl alcohol (PVOH) polymer, wherein the PVOH polymer comprises a polymer blend comprising a first PVOH copolymer comprising a first anionic monomer unit selected from the group consisting of acrylamido methylpropanesulfonic acids, alkali metal salts thereof, and combinations thereof, and a second PVOH copolymer comprising a second anionic monomer unit selected from the group consisting of monomethyl maleate, alkali metal salts thereof, and combinations thereof, wherein the first PVOH copolymer is present in an amount of about 20 wt. % of total PVOH polymers in the film; and the second PVOH copolymer is present in an amount of about 80 wt. % of total PVOH polymers in the film;
dipropylene glycol as a first plasticizer;
sorbitol as the second placticizer; and
glycerin as the third plasticizer; wherein the first, second, and third plasticizers are present in the water-soluble film in a combined amount in a range of about 5 parts to about 50 parts total plasticizer per 100 parts total resin (phr) in the water-soluble film; wherein the first plasticizer is present in the water-soluble film in an amount in a range of about 13 wt. % to about 58 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; wherein the second plasticizer is present in the water-soluble film in an amount in a range of about 13 wt. % to about 58 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; wherein the third plasticizer is present in the water-soluble film in an amount in a range of about 28 wt. % to about 73 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; and
b. a household care composition.
US Pat. No. 10,335,436

MEDICAL TREATMENT COMPOSITION COMPRISING MAMMALIAN DENTAL PULP STEM CELLS

1. A composition comprising:a biological material obtained from a cryopreserved mammalian dental pulp, the cryopreserved mammalian dental pulp including a cryoprotectant being dimethyl sulfoxide, wherein the biological material is in suspension form and includes:
(i) a plurality of non-cultured stem cells, including hematopoietic stem cells, and
(ii) extracellular matrix proteins;
wherein the composition is in a form that is safe for injection into a subject to treat a disease or injury.
US Pat. No. 10,340,049

ALPHA/BETA RADIATION SHIELDING MATERIALS

Savannah River Nuclear So...

1. A radiological barrier material comprising a matrix and a particulate having a cross sectional dimension of about 500 micrometers or less contained within the matrix, the particulate comprising a radiation absorber that absorbs either one or both of alpha and beta radiation, the particulate comprising a defined nanostructure, the defined nanostructure comprising an aluminosilicate nanotube, the radiation absorber comprising a metal oxide, the radiation absorber further comprising an energy absorbing chromophore on the surface of the particulate.
US Pat. No. 10,335,437

INJECTABLE BROWN ADIPOSE MICROTISSUES FOR TREATMENT AND PREVENTION OF OBESITY AND DIABETES

THE TRUSTEES OF COLUMBIA ...

1. A method of treatment for a metabolic disorder, comprising the steps of:(a) harvesting white adipose tissue fragments from a subject;
(b) transferring the white adipose tissue fragments obtained in step (a) to a bioreactor;
(c) culturing the white adipose tissue fragments in the bioreactor in the presence of factors that promote brown adipose tissue differentiation, to create brown adipose-like cells in cultured tissue fragments;
(d) recovering the cultured tissue fragments from the bioreactor; and
(e) administering a therapeutically effective amount of the cultured tissue fragments to a subject.
US Pat. No. 10,335,438

CAMELID COMPOUND(S), COMPOSITION(S) AND METHOD(S)

5. A method for treating a melanoma in a subject in need thereof, the method comprising:heating camel hump fat to liquefy the camel hump fat;
filtering the heated camel hump fat to remove a proteinaceous connective tissue of the camel hump fat;
allowing the camel hump fat to cool; and
applying the camel hump fat topically to the melanoma.
US Pat. No. 10,335,439

METHOD FOR PRODUCING HUMAN CORNEAL EPITHELIUM SHEET

JCR Pharmaceuticals Co., ...

1. A method for producing cells derived from human corneal epithelial cells, which comprises a process wherein, in a culture vessel separated into first and second chambers by a membrane having micropores that disallow cells to pass through, feeder cells are added to the first chamber and human corneal epithelial cells are added to the second chamber, said human corneal epithelial cells are cultured on the membrane having micropores by using a first medium containing a Rho-associated protein kinase (ROCK) inhibitor and a phosphodiesterase inhibitor, but not containing a mitogen-activated protein (MAP) kinase inhibitor and a TGF-? receptor inhibitor, and then said human corneal epithelial cells are cultured by using a second medium containing a phosphodiesterase inhibitor, a mitogen-activated protein (MAP) kinase inhibitor, and a TGF-? receptor inhibitor, but not containing a Rho-associated protein kinase (ROCK) inhibitor.
US Pat. No. 10,335,441

ORAL COMPOSITION CONTAINING BIFIDOBACTERIA AND CRUCIFEROUS VEGETABLE

SUNSTAR INC., Osaka (JP)...

1. An anti-obesity oral composition, comprising: a combination of (A) freeze-dried Bifidobacterium breve MCC 1274 (FERM BP-11175); and (B) broccoli powder, wherein the anti-obesity effects of Bifidobacterium breve MCC 1274 (FERM BP-11175) are enhanced.
US Pat. No. 10,335,442

METHOD FOR TOPICAL TREATMENT OF NAIL CONDITIONS

Marlinz Pharma, LLC, Hou...

1. A method of treating discoloration of nails, comprising: topically applying to said nails a composition comprising:from about 2 to about 15% by weight of a urea-based component;
from about 10 to about 55% by weight of a monohydric alcohol containing 2 to 4 carbon atoms;
from about 8 to about 20% by weight dimethyl isosorbide;
from about 15 to about 30% by weight of undecylenic acid;
from about 10 to about 25% by weight of a carboxylic acid component other than undecylenic acid; and
from about 4 to about 15% by weight of a diol containing 2 to 4 carbon atoms.
US Pat. No. 10,335,443

ORODISPERSIBLE FILM

HEXAL AG, Holzkirchen (D...

1. An orodispersible film consisting essentially of:a) a plant extract selected from the group consisting of a hedera helix leaf extract, a coptidis rhizoma extract, a primula veris extract, a primula elatior extract, and a thymus vulgaris extract or a mixture thereof;
b) hydroxypropyl methyl cellulose;
c) microcrystalline cellulose;
d) glycerol; and
e) maltodextrin, wherein said orodispersible film rapidly disintegrates in the oral cavity of a patient in less than 20 seconds.
US Pat. No. 10,336,981

RECOMBINANTLY ENGINEERED DIAZOTROPHS FOR WHOLE CELL HYDROCARBON PRODUCTION AND METHODS FOR MAKING AND USING THEM

The Regents of the Univer...

1. A whole cell method for recombinantly engineering the enzymatic synthesis of a carbon-carbon bond-comprising product compound in the cell, comprising:contacting a nitrogen-fixing, nitrogenase-expressing diazotroph bacteria with an exogenous carbon-containing compound or a plurality of exogenous carbon-carbon-containing compounds under conditions suitable to enzymatically form a carbon-carbon bond-comprising product compound, or a plurality of carbon-carbon bond-comprising product compounds, incorporating the exogenous carbon-containing compound or compounds in the nitrogen-fixing, nitrogenase-expressing diazotroph bacteria,
wherein the nitrogen-fixing, nitrogenase-expressing diazotroph bacteria is recombinantly engineered to increase hydrocarbon synthesis by decreasing or removing molybdenum transporter activity.
US Pat. No. 10,336,983

METHOD FOR INCREASING THE SPECIFIC PRODUCTION RATE OF EUKARYOTIC CELLS

Hoffmann-La Roche Inc., ...

1. A method for increasing specific productivity (qP) of a recombinant Chinese Hamster Ovary (CHO) cell that produces an exogenous polypeptide, the method comprising culturing the CHO cell in a culture medium comprising meta-tyrosine at a concentration of from 0.2 mM to 0.7 mM, whereby the specific productivity (qP) is increased by at least 5% compared to an identical culturing process without supplementation of meta-tyrosine in the culture medium.
US Pat. No. 10,335,446

METHODS OF TREATING DISEASES USING GRAPE PROTEINS

1. A method of treating leukemia in a human in need thereof consisting essentially of administering a therapeutically effective amount of a composition of grape seed and grape stem to said human in need thereof to effectively treat the leukemia in said human in need thereof.
US Pat. No. 10,336,984

METHOD OF MOLECULAR STRESS CONTROL

CPSI Holdings LLC, Owego...

1. A cell selection method comprising the steps of:applying a cell selection reagent to an in vitro heterogeneous population of cells, wherein the heterogeneous population of cells includes at least a first population of cancerous mammalian hepatic cells and a second population of non-cancerous mammalian hepatic cells, and the cell selection reagent is an unfolded protein response (UPR) pathway inhibitor or a UPR pathway inducer; and
exposing the heterogeneous population of cells to a stress regimen, wherein the stress regimen produces a cell-type specific stress response in the heterogeneous population of cells, and wherein the cell selection reagent selectively modulates the UPR pathway in a cell-type specific manner in one of the first population of cancerous hepatic cells or the second population of non-cancerous hepatic cells to confer protection from the stress regimen,
wherein the cell selection method is performed according to one of the following sets of parameters:
a) the cell selection reagent is salubrinal, the stress regimen includes a hypothermic condition, and the selective modulating extends viability of the first population of cancerous mammalian hepatic cells, or
b) the cell selection reagent is resveratrol (FR-48), the stress regimen includes a hypothermic condition, and the selective modulating extends viability of the second population of non-cancerous mammalian hepatic cells, or
c) wherein the cell selection reagent is salubrinal, the stress regimen includes hypoxic, normothermic storage, and the selective modulating extends viability of the second population of non-cancerous mammalian hepatic cells.
US Pat. No. 10,337,752

VENTILATION SYSTEM AND METHOD FOR AIR-CONDITIONING AN INTERIOR USING AT LEAST ONE SUCH VENTILATION SYSTEM

1. An arrangement comprising:an interior space and a ventilation system, said ventilation system having a conveying unit for feeding a supply airstream from outside of the interior space through the ventilation system to at least one air outlet channel arranged in the interior space, wherein the ventilation system has a recirculation path via which the airstream in the interior space can be fed entirely or partially to the conveying unit, and said interior space having at least one exhaust air opening with an adjustable width through which exhaust air can exit the interior space,
wherein the at least one air outlet channel is arranged at a distance from the at least one exhaust air opening, such that an airstream is established during the operation of the ventilation system from the at least one air outlet channel to the at least one exhaust air opening in the interior space,
wherein the ventilation system further comprises a humidifying device for supplying humidity into the interior space, said humidifying device comprising:
an ultrasound nebulizer comprised by the conveying unit for generating an aerosol from a liquid, said aerosol having liquid droplets which are sized to be carried by the airstream established in the interior space,
an aerosol feed for supplying the aerosol to at least one aerosol outlet channel, and
at least one aerosol outlet tube arranged in the interior space, each aerosol outlet tube arranged with respect to its longitudinal extension parallel and in functional proximity to an air outlet channel, such that the aerosol emerging from each aerosol outlet tube is captured by the airstream emerging from the air outlet channel in proximity.
US Pat. No. 10,335,447

SOLID BEVERAGE FOR CONDITIONING QI DEFICIENCY CONSTITUTION AND METHOD FOR PRODUCING THE SAME

1. A solid beverage for conditioning qi deficiency constitution, comprising: 25-60 parts by weight of polygonatum odoratum, 30-52 parts by weight of fuling, 28-53 parts by weight of Chinese dates, 26-48 parts by weight of arillus longan, 15-34 parts by weight of orange peels, 30-53 parts by weight of lilium brownii, 27-52 parts by weight of Chinese yam, 26-56 parts by weight of hyacinth bean, 37-77 parts by weight of dextrin, 15-43 parts by weight of maltodextrin, 18-50 parts by weight of soluble starch and 0.1-0.38 parts by weight of aspartame.
US Pat. No. 10,336,985

METHOD OF OBTAINING TERMINALLY DIFFERENTIATED NEURONAL LINEAGES AND USES THEREOF

1. A method of inducing transdifferentiation of mesenchymal stem cells (MSC), the method comprising:a. culturing MSC in a first culture medium comprising a growth factor selected for allowing formation of neuralized MSC (NMSC), said growth factor comprising epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and said NMSC being characterized by expression of Nestin;
b. allowing the NMSC to proliferate for a sufficient time during which said first culture medium is renewed at least once;
c. culturing the NMSC of (b) in a second culture medium comprising cerebrospinal fluid (CSF) for a time sufficient for the NMSC to differentiate into a population of cells including terminally differentiated neurons, astrocytes and oligodendrocytes, said population of cells is characterized by at least 10% expression [5] of Glial fibrillary acidic protein (GFAP) and Tubulin-beta-III, at least 10% expression of Microtubule-associated protein-2 (MAP-2) and S100 and at least a 10% expression of Galactosylceramidase (GalC) and 2? 3?-cyclic nucleotide 3?-phosphodiesterase (CNPase).
US Pat. No. 10,335,448

COMPOSITIONS AND METHODS FOR INHIBITING FIBROSIS

The UAB Research Foundati...

1. A method for reducing idiopathic pulmonary fibrosis in a subject, the method comprising administering to a subject having idiopathic pulmonary fibrosis a therapeutically effective amount of a proline-glycine-proline (PGP)-containing peptide.
US Pat. No. 10,336,986

CELL CULTURING ARTICLE AND METHOD FOR MANUFACTURING THEREOF

National Central Universi...

1. A cell culturing article, comprising:a base layer having a surface;
a hydrophilic copolymer layer positioned on the base layer, wherein the hydrophilic copolymer layer comprises a plurality of polyvinyl alcohol units, a plurality of polyvinyl alcohol derivative units and a plurality of itaconic acid units, the itaconic acid units comprise a plurality of carboxyl groups; and
a plurality of peptide chains individually conjugated on a surface of the hydrophilic copolymer layer, and at least one amino group of each of the peptide chains reacting with one of the carboxyl groups of the itaconic acid units to form an amide bond.
US Pat. No. 10,335,450

METHODS AND SYSTEMS FOR DELIVERY OF ZW1 HEPTAPEPTIDE

Transdermal Biotechnology...

1. An article for transdermal delivery, the article comprising:a composition comprising ZW1 (SEQ ID NO: 1), a carrier and lecithin.
US Pat. No. 10,336,988

METHODS FOR PURIFICATION OF A VIRUS PRODUCED IN VITRO AND CLEARANCE ASSAY FOR THE VIRUS

GRIFOLS, S.A., Barcelona...

1. A method of purifying hepatitis E virus (HEV) virus propagated in cell culture, the method comprising treating a sample comprising the HEV with a detergent, and purifying the HEV by both centrifugation or ultra-centrifugation and filtration or ultrafiltration, wherein the detergent is a detergent mixture comprising a combination of Triton X-100 and Lithium Dodecyl Sulfate.
US Pat. No. 10,336,989

CHLAMYDOMONAS VIOLAXANTHIN DE-EPOXIDASE ENZYME AND ITS USES

The Regents of the Univer...

1. An expression vector comprising a polynucleotide that comprises a nucleic acid sequence encoding a polypeptide having at least 95% identity to amino acids 57-876 of SEQ ID NO:1.
US Pat. No. 10,340,064

RARE EARTH PERMANENT MAGNETIC MATERIAL AND METHOD OF PREPARING THE SAME

BYD COMPANY LIMITED, She...

1. A rare earth permanent magnetic material comprising:a main phase represented by R1x1R2y1Fe1-x-y1-z1-u1Coz1Bu1, wherein R1 is at least one element selected from Pr and Nd; R2 is at least one element selected from Dy, Tb and Ho; x1, y1, z1 and u1 are weight percentages, 26%?x1+y1?34%, 0.01%?y1?4%, 0?z1?6%, and 0.78%?u1?1.25%; and
an auxiliary phase separated from or cladding the main phase, comprising a first auxiliary phase and a second auxiliary, wherein
the first auxiliary phase is represented by R3x2R4y2Fe1-x2-y2-z2-u2-v1COz2Bu2Mv1, where R3 is at least one element selected from Pr and Nd; R4 is at least one element selected from Dy, Tb and Ho; M is at least one element selected from Zr, Ga, Cu, Nb, Sn, Mo, Al, V, W, Si, Hf, Ti, Zn, Bi, Ta and In; x2, y2, z2, u2 and v1 are weight percentages, 35%?x2+y2?82%, 5%?y2?42%, 0?z2?40%, 0?u2?1.25%, and 0?v1?10%; and
the second auxiliary phase is represented by R5x3R6y3Fe1-x3-y3-z3-u3-v2Coz3Bu3Mv2, where R5 is at least one element selected from Pr and Nd; R6 is at least one element selected from Dy, Tb and Ho; M is at least one element selected from Zr, Ga, Cu, Nb, Sn, Mo, Al, V, W, Si, Hf, Ti, Zn, Bi, Ta and In; x3, y3, z3, u3 and v2 are weight percentages, 10%?x3+y3?32%, 0?y3?4.8%, 0?z3?40%, 0.15?u3?1.25%, and 31%?v2?50%.
US Pat. No. 10,335,453

COMPOSITIONS AND METHODS FOR IMPROVING SEXUAL FUNCTION

Nymox Corporation, Nassa...

1. A method of improving sexual function in a male with benign prostastic hyperplasia (BPH) and sexual dysfunction comprising administering to the male a therapeutically effective amount of the peptide comprising the amino acid sequence in SEQ ID NO. 66 (Ile-Asp-Gln-Gln-Val-Leu-Ser-Arg-Ile-Lys-Leu-Glu-Ile-Lys-Arg-Cys-Leu), wherein the method improves sexual function as determined by comparing the scores of a standardized questionnaire selected from the group consisting of the Brief Male Sexual Functional Inventory, the International Index of Erectile Function, and the Male Sexual Health Questionnaire.
US Pat. No. 10,335,710

METHOD FOR PRODUCING ANHYDROUS SUGAR ALCOHOL USING AZEOTROPIC DISTILLATION

SK Innovation Co., Ltd., ...

1. A method of preparing anhydrosugar alcohol, the method comprises:(a) dehydrating a sugar alcohol in the presence of a first solvent and a second solvent, both of which form an azeotrope with water, and an acid catalyst, by heating to a temperature at which a solvent mixture of the first solvent and the second solvent is refluxed; and
(b) removing a portion of the solvents, and then carrying out an additional dehydration reaction at a temperature of 120° C. to 180° C., and liquefying a mixture of water produced during the reaction and evaporated solvents mixture, followed by removal of the water and separation of the solvents,
wherein a boiling point of the first solvent is lower than that of the second solvent, and the first solvent is a hydrocarbon having a boiling point of 60° C. to 99.5° C.
US Pat. No. 10,336,991

MUTANT RB69 DNA POLYMERASE

LIFE TECHNOLOGIES CORPORA...

1. An isolated DNA polymerase comprising the amino acid sequence of any one of SEQ ID NOS: 5-8.
US Pat. No. 10,335,454

COMBINATION AND USE

HELPERBY THERAPEUTICS LIM...

1. A combination comprising suloctidil or a pharmaceutically acceptable derivative or prodrug thereof, and a polymyxin selected from polymyxin E and polymyxin B or a pharmaceutically acceptable derivative thereof.
US Pat. No. 10,336,992

METHODS FOR PURIFICATION OF ARYLSULFATASE A

Shire Human Genetic Thera...

1. A method of purifying recombinant arylsulfatase A (ASA) protein, comprisingproviding a sample of recombinant ASA protein;
subjecting the sample to a first chromatography step which is anion exchange chromatography,
subjecting the sample from the anion exchange chromatography to a second chromatography step which is mixed-mode chromatography,
subjecting the sample from the mixed-mode chromatography to a third chromatography step which is hydrophobic interaction chromatography, and
subjecting the sample from the hydrophobic interaction chromatography to a fourth chromatography step which is cation exchange chromatography,
wherein fractions from each chromatography step containing recombinant ASA protein are determined by detecting the presence of recombinant ASA protein or enzymatic activity, and
wherein the purified recombinant ASA protein has a specific activity of at least 75 U/mg,
wherein 1 Unit of enzyme activity is defined as the hydrolysis of 1 ?mol p-Nitrocatechol Sulphate (pNCS) per minute at 37° C., pH 5.0.
US Pat. No. 10,338,017

ELECTRIC GRID HIGH IMPEDANCE CONDITION DETECTION

Itron, Inc., Liberty Lak...

1. A method of configuring a plurality of meters that are measuring power provided by a transformer, to determine a voltage of a secondary of the transformer, wherein the transformer does not have a voltage meter, the method comprising:under control of one or more processors configured with executable instructions:
making a plurality of voltage and current measurements at each of the plurality of meters associated with the transformer;
calculating impedance values of each of the plurality of meters associated with the transformer to obtain calculated impedance values, wherein the calculated impedance values are based at least in part on measurements made at each of the plurality of meters;
utilizing the calculated impedance values for each of the plurality of meters, and at least some of the plurality of voltage and current measurements, to calculate, for each respective meter, a transformer secondary voltage;
averaging the calculated transformer secondary voltages of the respective meters to calculate an averaged transformer secondary voltage value;
while power is provided to each of the plurality of meters, detecting at least one of:
an instance of the transformer secondary voltage value, calculated by averaging voltages of the plurality of meters, below a first threshold value; or
an instance of a change, between sequential updates of calculated transformer secondary voltage, that is greater than a second threshold value; and reporting the detected instance.
US Pat. No. 10,340,067

MAGNETIC FLUID

1. High density dispersion comprising magnetic particles, obtained by a method comprising the steps ofproviding a dispersion with magnetic particles in an amount of 10-30 wt. % relative to a total weight of the dispersion, directly thereafter
providing a weak organic acid, or salt thereof, in an amount of 5*10?6-0.1 Mole acid/gr magnetic particle, and interacting the weak organic acid and magnetic particles, and
maintaining the pH at a basic value,
wherein after providing the weak organic acid the dispersion is washed one to four times, and
wherein a washed dispersion is re-dispersed in a solvent and wherein the dispersion is concentrated to more than 15% v/v,
wherein the magnetic particles are present in an amount >15 vol. % relative to a total volume of the dispersion, and in an amount >45 wt. % relative to a total weight of the dispersion, and wherein a weak organic acid is present in an amount of 5*10?6-0.1 Mole acid/gr magnetic particle on the magnetic particle.
US Pat. No. 10,335,455

METHOD FOR PREVENTION OR TREATMENT OF INTRACTABLE INFLAMMATORY BOWEL DISEASE

University of Miyazaki, ...

1. A method for alleviating or suppressing the progress of an inflammatory bowel disease in a patient afflicted with the disease, comprisingadministering to the patient an effective amount of adrenomedullin, a modified product thereof or a salt of the adrenomedullin or the modified product, each of which has an activity of suppressing inflammation in the patient, thereby alleviating or suppressing the progress of the inflammatory bowel disease in the patient,
wherein the alleviating or suppressing the progress of the inflammatory bowel disease in the patient comprises mucosal regeneration, and
wherein a steroid preparation, an immunosuppressant, or an anti-TNF-? agent is insufficiently effective for alleviating or suppressing the progress of the inflammatory bowel disease in the patient.
US Pat. No. 10,336,993

POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

Novozymes, Inc., Davis, ...

1. A nucleic acid construct, comprising a polynucleotide encoding a GH61 polypeptide having cellulolytic enhancing activity, wherein the polynucleotide is operably linked to one or more heterologous control sequences that direct the production of the GH61 polypeptide in a recombinant host cell, and wherein the GH61 polypeptide having cellulolytic enhancing activity is selected from the group consisting of:(a) a GH61 polypeptide having at least 95% sequence identity to the mature polypeptide of SEQ ID NO: 4;
(b) a GH61 polypeptide encoded by a polynucleotide that hybridizes under very high stringency conditions with the full-length complement of the mature polypeptide coding sequence of SEQ ID NO: 3 or the cDNA sequence of the mature polypeptide coding sequence of SEQ ID NO: 3, wherein the very high stringency conditions are defined as prehybridization and hybridization at 42° C. in 5×SSPE, 0.3% SDS, 200 micrograms/ml sheared and denatured salmon sperm DNA, and 50% formamide, for 12 to 24 hours, and washing three times each for 15 minutes using 2×SSC, 0.2% SDS at 70° C.; and
(c) a GH61 polypeptide encoded by a polynucleotide having at least 99% sequence identity to the mature polypeptide coding sequence of SEQ ID NO: 3 or the cDNA sequence of the mature polypeptide coding sequence of SEQ ID NO: 3.
US Pat. No. 10,336,994

SUBTILISIN VARIANTS HAVING A MUTATION IN THE S2 OR S2# POCKET

ENZYPEP B.V., Geleen (NL...

1. An enzyme, which enzyme is a subtilisin BPN? variant or homologue variant thereof, comprising the following mutations compared to subtilisin BPN? represented by SEQ ID NO: 2 or a homologue sequence thereof:a deletion of the amino acids corresponding to positions 75-83;
a mutation at the amino acid position corresponding to S221, the mutation corresponding to S221C or S221 selenocysteine; and
at least one further mutation selected from the group consisting of amino acid positions corresponding to F189W, F189Y, S33D, S33T, N218D, N218T, N218E, N62D, N62S, N62W, and N62Y; and
optionally, a mutation at the amino acid position corresponding to P225;
wherein the amino acid positions are defined according to the sequence of subtilisin BPN? represented by SEQ ID NO: 2.
US Pat. No. 10,339,557

SYSTEMS AND METHODS FOR PROVIDING OFFERS USING A MOBILE DEVICE

Capital One Services, LLC...

1. An offer system, comprising:a computing system configured to receive over a communication network:
transaction data for at least one prior transaction associated with a user of a wireless device; and
information indicating a current location of the wireless device;
one or more processors configured to execute programmable instructions to:
determine an offer based on the received information indicating the current location of the wireless device and the transaction data for the at least one prior transaction associated with the user of the wireless device,
wherein the offer is redeemable at a merchant location within a predetermined distance of the current location of the wireless device, and
wherein the computing system is further configured to transmit, over the communication network, the determined offer to the wireless device.
US Pat. No. 10,336,995

BETA-LACTAMASES WITH IMPROVED PROPERTIES FOR THERAPY

SYNTHETIC BIOLOGICS, INC....

1. A beta-lactamase comprising an amino acid sequence having at least 95% sequence identity with SEQ ID NO: 1 and the following mutations according to Ambler classification:an aliphatic hydrophobic residue other than glutamine (Q) at position 135.
US Pat. No. 10,335,458

PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING BONE CONDITIONS

The Regents of the Univer...

1. A method for inducing bone formation in a subject in need thereof comprising administering a carrier or scaffold comprising a human NELL polypeptide, bone morphogenic protein 2 (BMP2), and hyaluronan to the subject.
US Pat. No. 10,335,459

COMPOSITIONS FOR MODULATING IL-10 IMMUNOSTIMULATORY AND ANTI-INFLAMMATORY PROPERTIES

Alkermes, Inc., Waltham,...

1. A single chain IL-10 (scIL-10) polypeptide comprising an amino acid sequence arrangement from N-terminus to C-terminus in accordance with Formula 1:(first monomer subunit)-LINKER-(second monomer subunit)   Formula 1
wherein the first monomer subunit and the second monomer subunit may be independently selected from: SEQ ID NO: 1; or SEQ ID NO: 1 comprising at least one amino acid substitution, wherein the at least one amino acid substitution is at an amino acid position of SEQ ID NO: 1 that is selected from: amino acid position 22, amino acid position 41, amino acid position 87, and any combination thereof with the proviso that at least one of the first monomer subunit or the second monomer subunit comprises at least one amino acid substitution;
wherein LINKER is an amino acid linker of between 1 and 15 amino acids in length; wherein the amino acid substitutions comprise the substitution of amino acids of scIL-10 that interface with IL-10R1, IL-10R2 or amino acids that interface with both IL-10R1 and IL-10R2; and
wherein the scIL-10 polypeptide is optionally covalently attached to a fusion partner.
US Pat. No. 10,335,460

IL-15 AND IL-15R? HETERODIMER DOSE ESCALATION REGIMENS FOR TREATING CONDITIONS

NOVARTIS AG, Basel (CH) ...

1. A method for treating lymphocytopenia, cancer or an infectious disease in a human subject, comprising:(a) administering an initial low dose of a human IL-15/IL-15R? complex to the human subject, wherein the initial low dose is between 0.1 ?g/kg and 1 ?g/kg as determined based on the mass of single chain IL-15;
(b) obtaining a plasma sample taken from a human subject; and
(c) detecting a concentration of free IL-15 of 1 pg/ml to 50 pg/ml in the sample obtained from the subject after the administration of the initial low dose of the human IL-15/IL-15R? complex and administration of successively higher doses of the human IL-15/IL-15R? complex, wherein each successively higher dose is from two to three times higher than the previous dose.
US Pat. No. 10,336,998

MICROBIAL STRAIN IMPROVEMENT BY A HTP GENOMIC ENGINEERING PLATFORM

Zymergen Inc., Emeryvill...

1. A high-throughput method for engineering a host cell to have improved phenotypic performance, comprising:a. accessing a training data set containing one or more genetic alteration input variables and one or more measured phenotypic performance output variables,
i. wherein the one or more genetic alteration input variables represent one or more genetic alterations that have been introduced into a host cell, and
ii. wherein the one or more measured phenotypic performance output variables represent one or more phenotypic performance measurements that are associated with the one or more introduced genetic alterations;
b. developing a predictive machine learning model that is populated with the training data set;
c. generating, in silico, a pool of design candidate host cells incorporating the one or more genetic alterations;
d. utilizing the predictive machine learning model to predict the expected phenotypic performance of each member of the pool of design candidate host cells,
i. wherein at least one design candidate host cell comprises a consolidated combination of genetic alterations from among the genetic alterations of step (a), in a genomic sequence, said combination being uncharacterized for improving the phenotypic performance at the time that step (d) is carried out;
ii. wherein the expected phenotypic performance predicted by the machine learning model is based upon the introduced genetic alterations and their associated phenotypic performance measurements of step (a);
e. selecting a subset of the design candidate host cells based upon their predicted phenotypic performance;
f. manufacturing host cells from the subset of the design candidate host cells to thereby create engineered host cells;
g. measuring, in an in vitro assay, the phenotypic performance of the engineered host cells; and
h. adding to the training data set of (a):
i. one or more genetic alteration input variables representing one or more genetic alterations that were introduced into the engineered host cells, and
ii. one or more measured phenotypic performance output variables representing the phenotypic performance measurements of the engineered host cells.
US Pat. No. 10,335,975

PROCESS FOR TREATING WOOD

Dow Global Technologies L...

1. A method for preparing a treated cellulosic material comprising:(a) providing a cellulosic material, the cellulosic material comprising wood;
(b) a first treatment protocol comprising impregnating the cellulosic material with an aqueous dispersion comprising a polymer, the polymer comprising an olefin-carboxylic acid copolymer; and
(c) a second treatment protocol comprising impregnating the cellulosic material with a modifying agent, the modifying agent comprising a polyamine having greater than or equal to 2 amine groups.
US Pat. No. 10,336,999

COMPOSITIONS AND METHODS FOR ACTIVATING SILENT GENE CLUSTERS

Zymergen Inc., Emeryvill...

1. A method of activating one or more native genes in each bacterial cell in a population of bacterial cells, the method comprising:infecting the population of bacterial cells with a plurality of recombinant bacteriophage, wherein
(a) the bacteriophage are selected from a collection of recombinant phage comprising different heterologous nucleotide sequences that encode one or more bacterial transcription factors, and
(b) each bacterial cell expresses the one or more native genes because of the expression of the one or more bacterial transcription factors;wherein the one or more native genes are transcriptionally silent, poorly expressed, or poorly transcribed in a control bacterial cell that has not been infected with the bacteriophage comprising the different heterologous nucleotide sequences encoding the one or more transcription factors; and wherein the population of bacteriophage-infected bacterial cells express different sets of heterologous transcription factors.
US Pat. No. 10,335,462

USE OF LONG-ACTING GLP-1 PEPTIDES

1. A method for treating type 2 diabetes, comprising administering semaglutide once weekly in an amount of 1.0 mg to a subject in need thereof.
US Pat. No. 10,335,976

TREATED POROUS MATERIAL

Dow Global Technologies L...

1. A method for preparing a treated cellulosic material comprising:(a) providing a cellulosic material;
(b) a first treatment protocol comprising impregnating the cellulosic material with a liquid epoxy resin; and
(c) a second treatment protocol comprising impregnating the cellulosic material with a modifying agent suitable for curing the epoxy resin.
US Pat. No. 10,336,744

1AP E3 LIGASE DIRECTED PROTEOLYSIS TARGETING CHIMERIC MOLECULES

GlaxoSmithKline Intellect...

1. A compound selected from the group consisting of(S)-7-(2-(2-(2-(2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethoxy)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-N—((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide,
(S)-7-(2-(2-(2-(2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinolin-7-yl)oxy)ethoxy)ethoxy)ethoxy)ethoxy)-2-((S)-3,3-dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-N—((S)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide,
(S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)-7-(2-(2-(2-(2-(4-((6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)oxy)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)-N—((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, and
(2S,4S)-4-(14-(4-(4-((R)-3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobutyl)piperazin-1-yl)-3,6,9,12-tetraoxatetradecanamido)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N—((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide,or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,337,000

EXPRESSION VECTOR PRODUCTION AND HIGH-THROUGHPUT CELL SCREENING

KYMAB LIMITED, Cambridge...

1. A method of producing cells encoding a repertoire of antibody binding sites comprising a VH sequence and VL sequence, the method comprising:a) providing a population of cells expressing a repertoire of antibody binding sites, which cells are isolated from one or more animals and which comprise B cells, germinal center cells, memory B cells, antibody-secreting cells, plasma cells, or plasmablast cells;
b) sorting the population of cells by binding the antibody binding sites to an antigen of interest to produce a sorted population of single cells, each cell comprising nucleic acid encoding a respective antibody binding site, and each sorted cell provided in a separate container;
c) amplifying the nucleic acid comprised by the sorted single cell population using PCR to produce a sorted repertoire of amplified nucleic acids encoding antibody binding sites, wherein the VH and VL sequences of each antibody binding site are amplified in the same container;
d) modifying the sorted amplified antibody binding site-encoding nucleic acids from step (c) to produce a sorted repertoire of expression cassettes, each container comprising a first type of cassette comprising a nucleotide sequence encoding a VH sequence of an antibody binding site and one or more regulatory elements for expressing the VH sequence of the antibody binding site from said single cell, and a second type of cassette comprising a nucleotide sequence encoding a VL sequence of an antibody binding site and one or more regulatory elements for expressing the VL sequence of the antibody binding site from said single cell, wherein the VH and VL sequences of each antibody binding site are modified in the same container; and
e) transferring the antibody binding site expression cassettes from said cassette repertoire to a sorted population of host cells while maintaining the antibody binding site expression cassette sorting and producing a sorted repertoire of host cells that expresses a sorted repertoire of antibody binding sites, wherein the sorted repertoire of host cells is capable of stably expressing the repertoire of antibody binding sites.
US Pat. No. 10,337,256

POLYCRYSTALLINE DIAMOND CUTTERS HAVING NON-CATALYTIC MATERIAL ADDITION AND METHODS OF MAKING THE SAME

DIAMOND INNOVATIONS, INC....

1. A polycrystalline diamond compact, comprising:a polycrystalline diamond body comprising a working surface, an interface surface, and a perimeter surface; and
a substrate bonded to the polycrystalline diamond body along the interface surface,wherein a non-diamond volume fraction of the polycrystalline diamond body is greater at the interface surface than at the working surface,wherein the polycrystalline diamond body exhibits a concentration of non-catalytic material that is lower at the working surface than at the interface surface, andwherein the non-catalytic material is selected from the group consisting of lead, bismuth, and alloys, nitrides, carbides and carbonitrides thereof.
US Pat. No. 10,335,463

THERAPEUTIC AGENT PREPARATIONS FOR DELIVERY INTO A LUMEN OF THE INTESTINAL TRACT USING A SWALLOWABLE DRUG DELIVERY DEVICE

Rani Therapeutics, LLC, ...

1. A method for delivering growth hormone into a wall of an intestine, the method comprising:swallowing a drug delivery device comprising a capsule, an actuator having a first configuration and a second configuration and a growth hormone preparation operably coupled to the actuator, the growth hormone preparation comprising a therapeutically effective dose of growth hormone, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration; and
actuating the actuator responsive to a condition in the intestine to deliver the growth hormone preparation into the wall of the small intestine.
US Pat. No. 10,337,001

GUIDE RNA WITH CHEMICAL MODIFICATIONS

AGILENT TECHNOLOGIES, INC...

1. A synthetic CRISPR guide RNA having at least one 5?-end and at least one 3?-end, the synthetic guide RNA comprising:(a) one or more modified nucleotides within five nucleotides from said 5?-end, or
(b) one or more modified nucleotides within five nucleotides from said 3?-end, or
(c) both (a) and (b);
wherein said guide RNA comprises one or more RNA molecules, and has gRNA functionality comprising associating with a Cas protein and targeting the gRNA:Cas protein complex to a target polynucleotide, wherein the modified nucleotide has a modification to a phosphodiester linkage, a sugar, or both.